...Abuse of Acetophenetidin (Phenacetin)-Containing Preparations. This committee, composed of scientists in the fields of pharmacology and medicine, on April 23, 1964, submitted its findings and conclusions in the matter and recommended that all...

The effects of phenacetin (acetophenetidin) and the contaminant present in phenacetin, acetic-4-chloranilide (A4CA), were observed in young male Osborne-Mendel rats fed diets of these drugs for 22 weeks. The results suggest that the principal offending ag...

Liver regeneration was stimulated in male rats with two-thirds of the liver removed by feeding a basal diet supplemented with acetaminophen (0.35-1.5%; weight basis), 2-acetamidophenol (1.0%) and acetophenetidin (1.0%) over a period of 10 days po, but was in the control range with the m-isomer, 3-acetamidophenol (1.0%), N-butyryl-p-aminophenol (1.0%), o-, m- and p-aminophenols ...

By use of a high-performance liquid chromatographic procedure, phenacetin (acetophenetidin) and its O-de-ethylated metabolite paracetamol (acetaminophen), after hydrolysis of paracetamol conjugates, were simultaneously quantified in arterial plasma of both control and 3-methylcholanthrene-pretreated rats after the i.v., portal vein and intraduodenal administration of ...

Drug solubilization is an important aspect of drug development. We investigate the relationship between solute hydrophobicity on the solubilization properties of water-cosolvent mixtures. The solubilization in water-cosolvent mixtures of seven chemically unrelated drugs was determined. The set of solutes included hydrocortisone, sulfanilamide, acetophenetidine, benzocaine, ...

The aim of the study was a comprehensive swelling investigation of hydrocolloid tablets with drug release by diffusion, erosion and polymer particle erosion, respectively, in order to reveal differences in the swelling behaviour responsible for the diverging drug release mechanisms. Four different methods were applied to study swelling of the tablets: determination of the expansion factor, texture ...

A comparative study of cytochrome P450 phase 1 biotransformation enzyme activities of the Australian brushtail possum was conducted. Since its introduction to New Zealand this animal pest has caused considerable agricultural and ecological problems. The objective of this work was to probe for potential biochemical weaknesses that may be exploited for designing a more species-specific method of ...

Temperature dependencies of saturated vapor pressure for the monoclinic modification of paracetamol (acetaminophen), acetanilide, and phenacetin (acetophenetidin) were measured and thermodynamic functions of sublimation calculated (paracetamol: DeltaGsub298=60.0 kJ/mol; DeltaHsub298=117.9+/-0.7 kJ/mol; DeltaSsub298=190+/-2 J/mol.K; acetanilide: DeltaGsub298=40.5 kJ/mol; ...