... 0167 TITLE: Regulation of EGF Receptor Signaling by Histone Deacetylase 6 (HDAC6)-Mediated Reversible Acetylation ...
DTIC Science & Technology
... CELLS(BIOLOGY), *RECEPTOR SITES(PHYSIOLOGY), *GROWTH( PHYSIOLOGY), *ACETYLATION, *HISTONES, *BREAST CANCER ...
... OR15-2 Acetylation of Estrogen Receptor Alpha. ... defined biochemical assay, we have examined the mnchanism of ERa acetylation by p300 ...
... precursor, vascular endothelial growth factor receptor precursor, gamma-aminobutyric acid A receptor, nicotinic acetyl choline receptor, various neurotransmitter ... ...
NBII National Biological Information Infrastructure
... activator-dependent transcription, implicating a critical role for ... CELLS(BIOLOGY), REGULATIONS, SENSE ORGANS, STEROIDS, ACETYLATION ...
... Specifically, experiments were proposed to assess the role of histone acetylation and high mobility group (HMG) chromatin proteins in estrogen ...
... SENSE ORGANS, RECEPTOR SITES(PHYSIOLOGY), ABNORMALITIES, GROWTH(PHYSIOLOGY), ACETYLATION, ANDROGENS, HISTONES. ...
... 2004 Phosphorylation of estrogen receptor alpha blocks its acetylation and ... were resolved onto SDS-PAGE and visualized with autoradiography. ...
... Abstract : The activity of estrogen receptor a is activated by both ligand binding and various modifications including phosphorylation and acetylation ...
One of the hallmarks of cancer is uncontrolled cell growth and proliferation. In cells, a group of proteins called growth factor receptors are responsible for responding to the signals that trigger proliferation. When these receptors function abnormally d...
National Technical Information Service (NTIS)
Cytokine-activated receptors undergo extracellular domain dimerization, which is necessary to activate intracellular signaling pathways. Here, we report that in prolactin (PRL)-treated cells, PRL receptor (PRLR) undergoes cytoplasmic loop dimerization that is acetylation-dependent. PRLR-recruited CREB-binding protein (CBP) ...
PubMed Central
... 1986. Compart- mentalized regulation of macrophage arachidonic acid ... Toll-like receptor 2 and mitogen- and stress-activated kinase 1 are ...
-mutant animals to the paralytic effects of aldicarb, an acetyl- cholinesterase inhibitor, and levamisole, an acetylcholine receptor agonist. Resistance to these agents, particularly to levamisole, is a telltale sign
E-print Network
... that the predominant presence of the high molecular weight species of ... Polo, JR Acetyl-L-carnitine and receptors in the aging rat's hippocampus. ...
... The role of classical neurotransmitters including acetylcholine and norepinephrine in regulating myometrial contractility has been well studied; ... Although the classical neurotransmitters such as acetyl...
... similarly in that locus-wide histone acetylation in C4-2B cells not exposed to ligand was associated with sub- stantial gene expression at the loci. ...
Carbon monoxide dehydrogenase/acetyl-CoA synthase catalyzes acetyl-CoA synthesis from CO, CoA, and a methylated corrinoid iron-sulfur protein, which acts as a methyl donor. This reaction is the last step in the Wood-Ljungdahl pathway of anaerobic carbon fixation. The binding sequence for the three substrates has been debated for over a decade. Different ...
PubMed
Carbon monoxide dehydrogenase/acetyl-CoA synthase catalyzes acetyl-CoA synthesis from CO, CoA, and a methylated corrinoid iron-sulfur protein, which acts as a methyl donor. This reaction is the last step in the Wood-Ljungdahl pathway of anaerobic carbon fixation. The binding sequence for the three substrates has been debated ...
We show that the enzymatic acetylation and deacetylation of a cell surface carbohydrate controls B cell development, signaling, and immunological tolerance. Mice with a mutation in sialate:O-acetyl esterase, an enzyme that specifically removes acetyl moieties from the 9-OH position of alpha2-6-linked sialic acid, exhibit enhanced B ...
We show that the enzymatic acetylation and deacetylation of a cell surface carbohydrate controls B cell development, signaling, and immunological tolerance. Mice with a mutation in sialate:O-acetyl esterase, an enzyme that specifically removes acetyl moieties from the 9-OH position of ?2�6-linked sialic acid, exhibit enhanced B cell ...
Targeted therapeutic intervention in receptor-ligand interactions of p53 mediated tumor suppression can impact progression of disease, aging, and variation in genetic expression. Here, we conducted a number of molecular simulations, based on structures of p53 in complex with its transcriptional co-activating CBP bromodomain, determined by NMR spectroscopy, to investigate the ...
This book covers cholesterol and metabolism. Paper include: The LDL Receptor in Perspective, Cholesterol in Animal Tissues, HMG-CoA Reductase. acetyl-CoA: Cholesterol Acyltransferase, and LDL: Physical and Chemical Characteristics.
Energy Citations Database
Understanding the molecular mechanisms behind regulation of chromatin folding through covalent modifications of the histone N-terminal tails is hampered by a lack of accessible chromatin containing precisely modified histones. We study the internal folding and intermolecular self-association of a chromatin system consisting of saturated 12-mer nucleosome arrays containing various combinations of ...
The androgen receptor (AR) is a ligand activated transcription factor and member of the steroid hormone receptor (SHR) subfamily of nuclear receptors. In the early stages of prostate carcinogenesis, tumour growth is dependent on androgens, and AR directly mediates these effects by modulating gene expression. During transcriptional ...
The role of N-acetyltransferase 2 (NAT2) polymorphism in breast cancer is still unclear. We explored the associations between potential sources of exposure to aromatic and heterocyclic amines (AHA), acetylation status and receptor-defined breast cancer in 1020 incident cases and 1047 population controls of the German GENICA study. ...
A study was made of the influence of some plant lectins on the aggregation of neutrophils and erythrocytes in healthy humans, and the state of carbohydrate determinants of glycoprotein receptors of these cells was characterized. These carbohydrate determinants, containing D-mannose, N-acetyl-D-glucosamin, and bD-galactose, provide neutrophils aggregation ...
Posttranslational modifications in proteins play critical roles in synaptic plasticity and memory. In addition, the enduring form of long-term potentiation (LTP) and long-term memory require synthesis of proteins. Some of the mRNAs are present in the dendrites and are locally translated into proteins. Microtubules play critical roles in neuronal transport including the transport of mRNAs from the ...
The thyroid hormone receptor (TR)-alpha is a nuclear receptor that mediates both transrepression and ligand-dependent transactivation. Here we show that TRalpha is posttranslationally modified by acetylation in response to its own ligand (T(3)). Acetylation increases binding to DNA. Using mutagenesis, we identified ...
Using a variety of biochemical and cell-based approaches, we show that estrogen receptor a (ER?) is acetylated by the p300 acetylase in a ligand- and steroid receptor coactivator (SRC)-dependent manner. Using mutagenesis and mass spectrometry, we identified two conserved lysine residues in ER? (Lys266 and Lys268) that are the primary ...
