Sprouting of motor nerve terminals was evoked by functional denervation of skeletal muscles brought about by presynaptic blockade or disuse. The amount of sprouting, determined by morphometric measurement, was correlated with the level of extrajunctional acetylcholine receptors. Sprouting was inhibited by blockade ...
NASA Astrophysics Data System (ADS)
Alpha-Bungarotoxin (alphaBT) is a snake toxin which in vertebrate systems binds with great specificity to acetylcholine (ACh) receptors. The authors have studied the effects of alpha BT on the electrophysiological response to ACh of identifiable cells in ...
National Technical Information Service (NTIS)
... National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland D DC ... The authors wish to express their 1.-inks ...
DTIC Science & Technology
... Personal Author(s) : Shain, WG ; Greene, LA ; Carpenter, DO ; Sytkowski, AJ ; Vogel, Z. Handle / proxy Url : Report Date : FEB 1974. ...
The authors analyze the role of dopamine and muscarinic acetylcholine receptor blocking components in the antistereotypic action of neuroleptics with different chemical structure. To determine dopamine-blocking activity in vitro, binding of /sup 3/H-spiperone with membranes of the rat striatum was measured. To study the blocking action of the substances on ...
Energy Citations Database
The perhydro derivative of histrionicotoxin reversibly blocks the excitatory ionic transduction system in the synaptic and sarcolemmal membranes of mammalian skeletal muscle cells. The efficacy of perhydrohistrionicotoxin as an antagonist at the post-synaptic membrane is increased by the transient presence of acetylcholine in the endplate of innervated muscles and at ...
PubMed Central
Levels of mRNA for acetylcholine receptor (AChR) subunits are relatively low in innervated skeletal muscles. Following denervation they rise rapidly, leading to increased AChR synthesis. The mechanism by which motor nerves normally regulate these mRNA levels is not yet known. In order to determine the possible role of synaptic transmission in this process, ...
We investigated the interaction between ambient histamine and acetylcholine by studying ? oscillations in rat hippocampus, induced by bath application of acetylcholine (10 �M combined with 2 �M physostigmine). The power of ? was significantly increased by the H1 antagonist, fexofenadine, and H2 receptor agonist, dimaprit, and ...
PubMed
... Title : Turnover of Acetylcholine Receptors: Mechanisms of Regulation. ... Acetylcholine receptors, RA5 Neuromuscular junctions, Motor nerves. ...
... Title : Primary Structure of Nicotinic Acetylcholine Receptor. ... One of the neurotransmitters used in the mammalian brain is acetylcholine. ...
... Accession Number : ADD754483. Title : ACETYLCHOLINE RECEPTOR CHANNEL IMAGED IN THE OPEN STATE. Descriptive ...
... Title : ACETYLCHOLINE RECEPTOR BINDING CHARACTERISTICS OF SNAKE AND CONE SNAIL VENOM POSTSYNAPTIC NEUROTOXINS ...
The effect of selective histamine H3-receptor agonists and antagonists on the acetylcholine release from peripheral nerves was evaluated in the guinea pig longitudinal muscle-myenteric plexus preparations, preloaded with ({sup 3}H)choline. In the presence of H1 and H2 blockade, histamine and (R)-{alpha}-methylhistamine inhibited the ...
Background and purpose:? Asthma is characterized by reversible bronchoconstriction and airway hyperreactivity. Although M(3) muscarinic receptors mediate bronchoconstriction, nonselective muscarinic receptor antagonists are not currently recommended for chronic control of asthma. We tested whether selective blockade of M(3) ...
Available evidence supports the idea that muscle fibres provide retrograde signals that enable the expression of adult motoneuron electrical properties but the mechanisms remain unknown. We showed recently that when acetylcholine receptors are blocked at motor endplates, the electrical properties of rat motoneurons change in a way that resembles changes ...
... Title : Activation, Inactivation, and Desensitization of Acetylcholine Receptor Channel Complex Detected by Binding of Perhydrohistrionicotoxin. ...
An isotopic rubidium ion efflux assay has been developed for the functional characterization of nicotinic acetylcholine receptors on cultured neurons. This assay first involves the intracellular sequestration of isotopic potassium ion analog by the ouabain-sensitive action of a sodium-potassium ATPase. Subsequently, the release of isotopic rubidium ion ...
that neither basal release nor drug effects interact signi�cantly with the order of the dialysis sessions min prior to the insertion of the concentric dialysis probes (0.32 mm o.d., 2.0 mm exposed membrane of repeated dialysis sampling on stimulated ACh ef�ux, means, for maximal drug doses, from animals tested
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