... Title : Turnover of Acetylcholine Receptors: Mechanisms of Regulation. ... Acetylcholine receptors, RA5 Neuromuscular junctions, Motor nerves. ...
DTIC Science & Technology
... Title : The Ionic Channel of the Acetylcholine Receptor: Regulation by Sites Outside and Inside the Cell Membrane Which are Sensitive to ...
... Accession Number : ADB135605. Title : Turnover of Acetylcholine Receptors: Mechanisms of Regulation. Descriptive Note : Annual rept. ...
... Accession Number : ADA221409. Title : Turnover of Acetylcholine Receptors: Mechanisms of Regulation. Descriptive Note : Annual rept. ...
... The goal of this project is to elucidate the mechanisms of regulation of the ... Subject Categories : ANATOMY AND PHYSIOLOGY TOXICOLOGY. ...
... Accession Number : ADA197570. Title : Desensitization and Down Regulation of Muscarinic Acetylcholine Receptors. Descriptive Note : Final rept. ...
The synthesis, insertion and degradation of acetylcholine receptors (AChRs) of skeletal muscle cells as closely regulated both by the muscle cells and by the motor nerves that supply them. The goal of this project is to elucidate the mechanisms of regulat...
National Technical Information Service (NTIS)
The synthesis, insertion and degradation of acetylcholine receptors (AChRs) of skeletal muscle cells is closely regulated both by the muscle cells and by the motor nerves that supply them. The goal of this project is to elucidate the mechanisms of regulat...
The synthesis, insertion and degradation of acetylcholine receptors (AChRs) of skeletal muscle cells are closely regulated both by the muscle cells and by the motor nerves that supply them. The goal of this project is to elucidate the mechanisms of regula...
The regulation of muscarinic acetylcholine receptors by short-term exposure to agonists was investigated in intact mouse neuroblastoma (clone N1E-115) cells, using the hydrophilic ligand (tritium)N-methylscopolamine. It was found that preincubation of cel...
... to growth in cell culture, so that the molecular and cellular mechanisms ... RECEPTION, ESTERS, CELLS(BIOLOGY), MOLECULAR PROPERTIES ...
The document is a review of research on the mechanisms which genetically regulate the compartmentalized expression of acetylcholine receptors (AchR) in adult vertebrate muscle tissue. It discusses studies of regulation through electrical activity, in part...
The original goal of this proposal was to determine the effects of electrical depolarization on muscarinic acetylcholine receptors (mAChR) in the cultured neuroblastoma cell line, N1E-115. Previous results in a variety of systems suggested that electrical...
Purified ? -toxin from Naja nigricollis snake venom labeled by [3H]acetylation binds specifically to the acetylcholine receptors of mouse neuroblastoma cells. Toxin binding was inhibited by inhibitors for nicotinic and muscarinic acetylcholine receptors. Clones of neuroblastoma cells were selected for low ...
NASA Astrophysics Data System (ADS)
Tritiated acetylcholine was used to measure binding sites with characteristics of nicotinic cholinergic receptors in rat brain. Regulation of the binding sites in vivo was examined by administering two drugs that stimulate nicotinic receptors directly or indirectly. After 10 days of exposure to the cholinesterase ...
... Title : Primary Structure of Nicotinic Acetylcholine Receptor. ... One of the neurotransmitters used in the mammalian brain is acetylcholine. ...
... Accession Number : ADD754483. Title : ACETYLCHOLINE RECEPTOR CHANNEL IMAGED IN THE OPEN STATE. Descriptive ...
... Title : ACETYLCHOLINE RECEPTOR BINDING CHARACTERISTICS OF SNAKE AND CONE SNAIL VENOM POSTSYNAPTIC NEUROTOXINS ...
The nicotine receptor for the neurotransmitter acetylcholine is an allosteric protein composed of four different subunits assembled in a transmembrane pentamer ? 2? ? ? . The protein carries two acetylcholine sites at the level of the ? subunits and contains the ion channel. The complete sequence of the four subunits is known. The ...
Neural circuits regulate cytokine production to prevent potentially damaging inflammation. A prototypical vagus nerve circuit, the inflammatory reflex, inhibits tumor necrosis factor-? production in spleen by a mechanism requiring acetylcholine signaling through the alpha 7 nicotinic acetylcholine receptor ...
PubMed
... The role of classical neurotransmitters including acetylcholine and norepinephrine in regulating myometrial contractility has been well studied; ... Although the classical neurotransmitters such as acetyl...
NBII National Biological Information Infrastructure
... W. and Berman, JD (1989) Mechanism of agonist-induced down-regulation and subsequent recovery of muscarinic acetylcholin receptors in a ...
Muscarinic acetylcholine receptors are members of the G-protein coupled receptor superfamily that are expressed in and regulate the function of neurons, cardiac and smooth muscle, glands, and many other cell types and tissues. The correct trafficking of membrane proteins to the cell surface and their subsequent ...
PubMed Central
Intact rat brain cells were dissociated and used to study the regulation of muscarinic acetylcholine receptors upon exposure to muscarinic receptor agonists. Incubation of cells with carbamylcholine resulted in a time-dependent decrease in subsequent (/sup 3/H)N-methylscopolamine specific binding, an effect which ...
Energy Citations Database
The nicotinic acetylcholine receptor of skeletal muscle is composed of five subunits that are assembled in a stepwise manner. Quality control mechanisms ensure that only fully assembled receptors reach the cell surface. Here, we show that Rer1, a putative Golgi-ER retrieval receptor, is involved in the biogenesis ...
by the American College of Cardiology The parasympathetic nervous system acts through the vagus nerve to regulate stimulation leads to a release of acetylcholine from the vagus nerve. Acetylcholine binds muscarinic receptors). DISCUSSION Acetylcholine is released from the vagus nerve of the ...
E-print Network
. A significant loss of RACK1 has been found in the brain of aging animals and Alzheimer's disease (AD) patients acetylcholine receptors; IPSC; Sindbis virus; Stereotaxic injection RACK1 is a member of the tryptophan by muscarinic acetylcholine receptors (mAChR) and metabotropic glutamate ...
... Title : Activation, Inactivation, and Desensitization of Acetylcholine Receptor Channel Complex Detected by Binding of Perhydrohistrionicotoxin. ...
Acetylcholine plays an important role in regulating the processing of sensory stimuli, and understanding its specific cellular actions is critical to understanding how sensory cortex develops and functions in different behavioral states. Here we review recent work on the cellular effects of nicotinic receptor activation in auditory ...
The a1 subunit of nicotinic acetylcholine receptors in the inner ear: transcriptional regulation of the inner ear effer- ent system. In this study, we identify two novel nAChR subunits in the inner ear: a1 promoter of CHRNA1. Thus, Chrna1 could be the first transcriptional tar- get of ATOH1 in the inner ear. Co
Electrical activity has been shown to play an important role in the regulation of functional properties of neurons and other electrically excitable cells. One mechanism by which neuronal function is regulated is via alterations in the number of neurotrans...
