Eighty-nine patients with FIGO stages 3 and 4 epithelial ovarian cancer who responded to cis-platinum alone or cis-platinum containing combinations have been studied retrospectively to determine the time taken to achieve maximum tumour response. Clinically determined partial and complete responses were seen within ...

... a matching tissue type. Treating CML after a stem cell transplant: Some people who have a stem cell transplant may not achieve a complete response. If ...

Upon completion of this class, the participant will be able to discuss his/her responsibilities for maintaining exposures to radiation and radioactive material As Low As Reasonably Achievable.

Upon completion of this class, the participant will be able to discuss his/her responsibilities for maintaining exposures to radiation and radioactive material As Low As Reasonably Achievable.

Most patients with multiple myeloma achieve a complete or near complete response following autologous transplantation. However, patients experience disease relapse from a persistent reservoir of chemotherapy resistant disease. There has been strong intere...

BackgroundThis retrospective pooled analysis of two phase III trials (MM-009/MM-010) compared clinical outcomes of patients who achieved a complete response or very good partial response to treatment with lenalidomide plus dexamethasone with the outcomes of those who only achieved a partial ...

Upon completion of this class, the participant will be able to discuss his/her responsibilities for maintaining exposures to radiation and radioactive material As Low As Reasonably Achievable. The participant will be able to select the correct response fr...

This paper aims to update the therapeutical strategies in liver metastasis with complete clinical response (CCR) after chemotherapy and to determine if surgery is always necessary after CCR. The aim of chemotherapy is to achieve a good clinical response rather than CCR of liver metastasis. The CCR of liver ...

Tyrosine kinase inhibitors (TKI) have dramatically changed the management and the outcome of chronic myeloid leukemia (CML) patients. Imatinib is recognized as gold standard first-line therapy and impressive clinical and cytogenetic responses are obtained in the majority of chronic phase patients treated with this drug. Quantitative polymerase chain reaction (RQ-PCR) tool is ...

A case of extensive periungual viral warts in an immunocompetent patient that failed to respond to standard treatments over a 10-year period is reported. A rapid and complete response to treatment was achieved with oral acitretin. PMID:20443666

The acousto-ultrasonic method of nondestructive evaluation is an extremely sensitive means of assessing material response. Efforts continue to complete the understanding of this method. In order to achieve the full sensitivity of the technique, extreme ca...

Ovarian carcinoma is one of the most responsive solid tumors, with the majority of affected women now achieving complete remissions; unfortunately, most of these women eventually relapse and die from the disease. We hypothesized that the initial clinical ...

A nine year old spayed female Collie was diagnosed as having pemphigus vulgaris. Response to corticosteroid and antibiotic therapies was unsatisfactory. Aurothioglucose therapy was used later as the sole treatment. The dog achieved a complete remission lasting at least ten months.

Many patients with chronic myeloid leukemia who have failed initial therapy with a tyrosine kinase inhibitor achieve a cytogenetic response that is not complete (ie, partial or minor). This study analyzes the clinical benefit of such responses and identifies value in achieving such ...

The combination of peginterferon and ribavirin is the most effective therapy for patients with chronic hepatitis C virus (HCV) infection. Although more than half of all patients are able to achieve a sustained virologic response (SVR), a significant proportion of patients, particularly those with genotype 1, fail to have undetectable HCV RNA during ...

Combination therapy with azacitidine and etanercept was hypothesized to lead to improved responses in myelodysplastic syndrome (MDS) patients. Thirty-two patients with MDS/chronic myelomonocytic leukaemia were treated with azacitidine + etanercept; 30 completed at least three therapy cycles. At 3 months, nine patients had achieved ...

SummaryCombination therapy with azacitidine and etanercept was hypothesized to lead to improved responses in myelodysplastic syndrome (MDS) patients. Thirty-two patients with MDS/chronic myelomonocytic leukaemia were treated with azacitidine+etanercept; 30 completed at least three therapy cycles . At 3 months, nine patients had ...

We report a case of long-term (9 years) response to 4th-line endocrine treatment with fulvestrant given for advanced breast cancer after no or poor response to prior endocrine therapies. Complete remission was achieved with full dose and maintained even after dose reduction due to unanticipated intensity of mucosal ...

PurposeSome patients with rhabdomyosarcoma (RMS) achieve less than a complete response (CR) despite receiving all planned therapy. We assessed the impact of best response at the completion of all therapy on patient outcome.Patients and MethodsWe studied 419 clinical group III participants who ...

Patients with chronic myeloid leukemia, treated with imatinib, who have a durable complete molecular response might remain in CMR after stopping treatment. Previous reports of patients stopping treatment in complete molecular response have included only patients with a good response to ...

One hundred forty-nine patients with localized nonsmall cell carcinoma of the lung (Stage III A and B) were treated with two monthly cycles of initial chemotherapy that included vindesine-cisplatin followed by 6000 cGy of thoracic irradiation. Patients with complete, partial, and minor response after initial chemotherapy were randomized into groups to ...

A study of the relationship between student perceptions and learning behaviors attempted to answer the questions: (1) What are the perceptions of academic responsibility of the students? (2) How different are their perceptions when school, class, level of performance, and gender are different? and (3) To what extent is their perception of responsibility ...

A 40-year-old female with chronic myelogeneous leukemia (CML) in the chronic phase was treated with imatinib mesylate (STI571) because of interferon resistance. She achieved complete cytogenetic response but not complete molecular response 3 months after STI571 administration. Six months later, ...

BackgroundDasatinib 100 mg once daily achieves intermittent BCR-ABL kinase inhibition and is approved for chronic-phase chronic myeloid leukemia patients resistant or intolerant to imatinib. To better assess durability of response to and tolerability of dasatinib, data from a 2-year minimum follow-up for a dose-optimization study in chronic-phase chronic ...

In 2004, we reported the short-term results of a multicentric, phase 2 study of imatinib 400 mg daily and pegylated interferon-alpha in the treatment of 76 early chronic phase Philadelphia-positive chronic myeloid leukemia patients. In this report, we update the results with an observation time of five years. After two years of treatment, all but 10 patients (13%) had discontinued pegylated ...

A report is given on the results achieved in the palliative treatment of bone metastases by means of conventional radiotherapy in fifty unselected patients with different types of primary tumours. 14 % showed and excellent response and in 56 % a good result was obtained. In 14 % of the patients the treatment was unsuccessful, while in 16 % it was not ...

The objective of this project was to examine existing literature and national data to identify key factors in achieving quality outcomes from shorter duration apprenticeships and traineeships. It was found that apprentices and trainees undertaking programs of two years or less have a higher rate of non-completion than those doing longer training and this ...

Chemotherapy continues to be the treatment of choice for advanced/metastatic bladder cancer. Although response rates as high as 70% have been achieved, there continue to be high progression rates and poor long-term survival. Surgical consolidation offers improved outcomes compared with chemotherapy alone, especially in patients who ...

Advanced hepatocellular carcinoma has a dismal prognosis, with a median overall survival of 7.9 months if untreated and of 10.7 months if treated with sorafenib. We present a case of advanced previously unresectable hepatocellular carcinoma in a 49-year-old man that achieved a pathologic complete response and was made amenable to ...

Management of gastric cancer in older adults is challenging. Perioperative treatment with epirubicin, cisplatin, and 5-fluorouracil combination chemotherapy and surgery is considered the standard treatment of locally advanced gastric adenocarcinoma. However, this chemotherapy regimen is not well tolerated in older adults. Here, we report a case of an older patient with locally advanced gastric ...

We describe a patient with Kleine-Levin syndrome who was initially misdiagnosed as having epilepsy and who achieved complete remission on carbamazepine treatment. A drug effect was established when symptoms recurred after carbamazepine taper and disappeared after reintroduction of the drug. Carbamazepine, a safer drug than lithium, can be a highly ...

Sheehan's syndrome presents with panhypopituitarism after childbirth, usually preceded by post partum hemorrhage. Hematological abnormalities like pancytopenia with hypocellular marrow in these patients are reported rarely. Though multiple hormone deficiencies may contribute to Pancytopenia in Sheehan's syndrome, complete recovery is observed after ...

Imatinib-resistant tyrosine kinase (TK) fusions involving FGFR1, JAK2, or FLT3 are rare but recurrent in patients with eosinophilia-associated neoplasms. We report here 2 male patients with ETV6-FLT3(+) myeloid/lymphoid neoplasms with eosinophilia who were treated with the multitargeted TK inhibitors sunitinib and sorafenib. Patient 1 achieved rapid ...

The report presents data from 2,043 questionnaires completed by secondary student leaders and high achievers. Ss were selected for recognition in "Who's Who Among American High School Students" by their principals or guidance counselors, national youth organizations, or the publishing company because of high achievement in academics, ...

Although African Americans continue to demonstrate a desire for education, Black male enrollment and completion rates in higher education are dismal when compared to other ethnic groups. Researchers and scholars have noted various theories and philosophies responsible for the academic disengagement of African American men in higher education. This article ...

An accurate frequency response characterization method for photoreceivers with optical heterodyne technique is presented in this paper. The characterization is implemented with two single-mode tunable lasers operating near the wavelength of 1.55 ?m. The errors introduced by extra fixtures as well as laser output fluctuations are considered and calibrated simultaneously. ...

Radiation therapy is the most effective single agent for the treatment of mycosis fungoides. There are well-defined dose-response relationships for achieving a complete response as well as the durability of this response. Techniques of electron beam therapy have been developed that permit ...

BackgroundImatinib mesylate is the first line treatment for chronic myeloid leukemia. The advent of imatinib increased survival significantly in patients in an advanced phase of the disease. However, few long-term data on the outcome of these patients based on large, prospective and controlled trials are available.Design and MethodsA phase 2 multicenter trial of the use of imatinib 600 mg/daily in ...

PATIENTS: Fifteen patients with light chain deposits in the form of AL-amyloidosis and 2 patients with light chain deposition as amorphous matter (light chain deposition disease) were treated at our clinic as of 1999. Median age at the diagnosis was 63 (34-77) years. The light chain deposition caused: nephrotic syndrome in 12 (70%) patients, renal insufficiency with reduced filtration in 4 (23%) ...

Twenty-four patients with recurrent and/or locally advanced nasopharyngeal carcinoma who received cis-platinum-based chemotherapy are reported. Twelve patients with recurrent disease previously treated with radiotherapy received cis-platinum-based chemotherapy. An overall response rate of 67% (8/12) and a complete response (CR) of 25% ...

... false Responsibilities following project completion. 39.23 Section 39...Responsibilities, Inspections, and Reports Following Project Completion § 39.23 Responsibilities following project completion. (a) States...

... false Responsibilities following project completion. 39.23 Section 39...Responsibilities, Inspections, and Reports Following Project Completion § 39.23 Responsibilities following project completion. (a) States...

Imatinib and recombinant interferon alpha (rIFNalpha) can induce remission in polycythemia vera (PV) patients, but gauging the depth of responses has not been possible due to lack of a specific disease marker. We found that patients undergoing imatinib (n = 14) or rIFNalpha (n = 7) therapy remained strongly positive for V617F JAK2, although there was a significant reduction in ...

... Title : Response Action Outcome Completion Report for Medical Training Facility, Westover Air Reserve Base, Massachusetts. ...

Page 1. Guidance for Industry Submitting and Reviewing Complete Responses to Clinical Holds ... Submitting and Reviewing Complete Responses to Clinical Holds ...

Background:For patients with advanced laryngeal cancer, a trial was designed to determine if chemotherapy alone, in patients achieving a complete histologic tumor response (HCR) after a single neoadjuvant cycle, was an effective treatment with less morbidity than concurrent chemoradiation (CRT).Methods:Thirty-two patients with advanced ...

BACKGROUND: Nilotinib is a selective, potent BCR-ABL inhibitor. Previous studies demonstrated the efficacy and safety of nilotinib in Philadelphia chromosome-positive chronic myeloid leukemia patients in chronic phase (CML-CP) or accelerated phase who failed prior imatinib. METHODS: This expanded access trial further characterized the safety of nilotinib 400 mg twice daily in patients with CML-CP ...

A program of combination sequential chemotherapy using cyclophosphamide, vincristine, methotrexate with leucovorin rescue, and cytarabine (COMLA) was administered to 42 previously untreated patients with advanced diffuse histiocytic lymphoma. Twenty-three patients achieved a complete remission as determined by strict clinical restaging criteria. The ...

BackgroundPlasma cell leukemia (PCL) is a rare lymphoproliferative disorder considered to be a variant of multiple myeloma. It is an aggressive disease with a poor clinical response to standard chemotherapeutic agents.Case presentationA novel regimen consisting of bortezomib, doxorubicin, and dexamethasone is currently under active evaluation for the treatment of multiple ...

Anemia and other hematological abnormalities are common in patients with Sheehan's syndrome. The response of these abnormalities to replacement of thyroxine and glucocorticoids is not clear. The aim of the present study was to document the profile of hematological abnormalities and response to treatment in patients with Sheehan's syndrome. Forty patients ...

We report the results of rituximab monotherapy in 21 patients with refractory or relapsed aggressive non Hodgkin s lymphoma (NHL). The majority of the patients (16/21) were refractory to conventional treatment and not eligible for high dose chemotherapy. Responses (1 complete and 6 partial) were achieved in some of these patients and ...

RNA). The discovery that RNA molecules can regulate gene expression completely altered this simplistic picture (1RNAs that are generally responsible for regulating gene expression exhibit an exact or partial complementarity regulatory ncRNA among the set of potential regulators, while achieving a pruning efficiency of 86

disk requests that are found to be completed before their desired response times. (2) Average security level is the average value #12;13 of security levels achieved all disk requests issued to the disk system, the average security overhead and overall performance of AWARDS decreases, because the security levels of disk

Long-term protection and antibody response for the subunit vaccine F1-rV270 were determined by using the mouse model. Antibodies to F1 and rV270 were still detectable over a period of 518 days. The complete protection against lethal challenge of Yersinia pestis could be achieved up to day 518 after primary immunization.

). Schedulers are designed to achieve goals such as minimizing the completion time of the last job ex- ecuted (i attempt to design an incentive-compatible mechanism for scheduling non-malleable parallel jobs algorithm for minimizing the weighted response time of non-malleable jobs. Kwon and Chwa [11] designed

... HOMELAND SECURITY ... to) - Title and Subtitle HOMELAND SECURITY Responsibility And Accountability For Achieving National Goals ...

Objectives� To quantify response rates of S�zary syndrome (SS) to multimodality immunomodulatory therapy and to identify the important prognostic parameters that affect overall response to treatment. DESIGN: Retrospective cohort study. SETTING: Cutaneous T-cell lymphoma clinic at The Hospital at the University of Pennsylvania. PARTICIPANTS: ...

... racquetball, volleyball, boxing, jogging and weightlifting. My greatest personal achievement was training for and completing a marathon in 2002. ...

... reaches an equilibrium. Complete fluidization of the powder is essential to achieving consistent production results. There are ...

Over the last few years, there has been considerable work in progress to study the features of the piezoelectric polymer film polyvinylidene fluoride (PVDF) under high pressure shock loading. Although full characterization of the material is not complete, it is clear that if the material is prepared with careful attention to the mechanical processing (stretching) and to the ...

This Phase 2 study was designed to test the tolerance and effectiveness of concurrent cisplatin-radiotherapy in the treatment of invasive bladder cancer. Objectives were to determine toxicity, complete response rate, bladder preservation rate, and survival. Patients with invasive bladder cancer, clinical Stages T2--4, NO-2 or NX, MO were treated with ...

Aliment Pharmacol Ther 2011; 34: 767-774 SUMMARY: Background? An increasing number of patients with chronic hepatitis B (CHB) have experienced treatment failure to adefovir (ADV) and their management poses a growing challenge. Very limited data are available on the efficacy of entecavir (ETV) in patients previously treated with ADV. Aim? To examine the effect of ETV monotherapy on HBV DNA and ALT ...

We analyzed the association between achievement of early complete cytogenetic response (CCyR) and event-free (EFS) and overall survival (OS) in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib 400 mg (n=73), or imatinib 800 mg daily (n=208), or second generation tyrosine kinase ...

The application of the Rappaport classification for non-Hodgkin lymphoma has allowed for the stratification of histologic subtypes with consistent clinical correlations. Nodularity imparts a favorable prognosis and response to chemotherapy; diffuse patterns are unfavorable. Fifty percent survivals of 5 to 9 years and 1 to 2 years are observed for nodular and diffuse types, ...

A Phase I Pilot Study combining interstitial or intracavitary irradiation using /sup 192/Ir or /sup 137/Cs and interstitial hyperthermia in advanced or recurrent tumors is underway at the City of Hope National Medical Center. Hyperthermia is performed using 0.5 megahertz RF (500 kilohertz) radiofrequency localized current fields. In the implanted volume, a temperature of 41/sup 0/ to 45/sup 0/C is ...

This study examined how constructivist teaching and the organization of the learning environment relate to student achievement. The researchers used structural equation modeling (SEM) to examine the relationships among school and teaching attributes and student achievement in reading, writing, and mathematics as measured by the Washington Assessment of ...

COMP treatments were chop-burn, complete woody plant control, complete herbaceous plant control for 4 years, and complete woody and herbaceous (W+ H) ...

ContextThe Treatment for Adolescents with Depression Study evaluated fluoxetine (FLX), cognitive-behavioral therapy (CBT), and FLX/CBT combination (COMB), versus pill placebo (PBO) in 439 adolescents with major depressive disorder. Treatment consisted of three stages: (I) acute (12 weeks), (II) continuation (6 weeks), and (III) maintenance (18 weeks).ObjectiveExamine rates of ...

The incorporation of rituximab into various regimens has improved depth of response in Waldenstrom macroglobulinaemia (WM), though the impact of achieving better responses remains to be determined. We examined response depth on progression-free survival (PFS) in 159 rituximab-na�ve WM patients who received ...

Efficacy of PDT with new chlorin e6 photosensitizer (BLC 1010) has been tested in 72 cancer patients. 44 patients (61 %) achieved a complete response and 39 % of the patients a partial response (28 patients, including 15 patients treated for palliation). Rapid elimination of BLC 1010 from the organism solves the ...

The Superfund removal program has achieved significant accomplishments in responding to environmental emergencies, cleaning up hazardous waste sites, and making sites safe. For this reason, EPA publishes the Superfund Emergency Response Actions summary, which provides the public with valuable information about Superfund removal actions undertaken by EPA. ...

A method is presented for predicting the saturation levels and particle transport in weakly unstable systems where there are a discrete number of modes. Conditions are established for either steady state or pulsating responses when several modes are excited for cases where there is and there is not resonance overlap. The conditions for achieving different ...

We report on a 71-year-old woman with parapharyngeal sarcoma. Surgery could not be performed because of the size and location of the tumor. After failure of four cycles of chemotherapy, intensity-modulated radiation therapy (IMRT) achieved complete clinical response and partial magnetic resonance imaging response ...

We report a 49-year-old Chinese male with locally advanced gastric adenocarcinoma achieving pathological complete response after neoadjuvant chemotherapy with trastuzumab-containing regimen. He underwent esophagogastroduodenoscopy in September 2009, which revealed a 2-cm gastric ulcer on the lesser curvature proximal to angularis. ...

Patients with follicular lymphoma and a low tumor burden have a median overall survival of more than 10 years. Toxic conventional chemotherapy regimens are inappropriate in these patients, as they do not improve overall survival and the patients do not require palliation of symptoms. However, as most of these patients will ultimately die of their lymphoma, new therapies, with curative intent, are ...

This study examined the effect of improvements in timing/rhythmicity on students' reading achievement. 86 participants completed pre- and post-test measures of reading achievement (i.e., Woodcock-Johnson III, Comprehensive Test of Phonological Processing, Test of Word Reading Efficiency, and Test of Silent Word Reading Fluency). ...

In order to investigate the medical treatment of anal canal carcinoma (ACC), 27 patients (pts) were treated with cisplatin, fluorouracil and radiotherapy, in an alternating schedule. Eleven pts received mitomycin C, fluorouracil and radiotherapy, in a concurrent scheme. Finally, six pts were included in a new outpatient scheme with cisplatin, fluorouracil, leucovorin, mitomycin C and concurrent ...

PurposeThe Southwest Oncology Group conducted a randomized trial of induction BCG with or without maintenance BCG. In these additional retrospective analyses, our goal was to evaluate the association of a complete response (CR) or remaining with no evidence of disease (NED) versus no CR during induction therapy with subsequent survival after adjusting for ...

A retrospective review was undertaken of the records of 69 patients treated by radical irradiation between 1972 and 1977 for T2 Grade III and T3 bladder cancer. Twenty-six of the patients were treated to a tumor dose of 54 Gy in 2 Gy fractions using five daily fractions per week and 24 of the patients were treated to a tumor dose of 48.6 Gy in 3.47 Gy fractions given tri-weekly. The tumor ...

Background:The complete resection of liver metastases from colorectal cancer is the major determinant of longterm survival. The effectiveness of current chemotherapy regimens has made treatment algorithms more flexible and resulted in many different options. Recently, the pathological response to chemotherapy has emerged as another important prognostic ...

Background? Cryotherapy is a physical procedure whose immunogenic capability enables it to destroy tumour cells, at least partially. Consequently, it can boost the effect of imiquimod. Objective? The objective of the present study was to evaluate the efficacy of combining cryotherapy and imiquimod in patients who did not achieve a complete ...

Thirty-one patients with chronic lymphocytic leukemia were treated with mediastinal radiation. In none of the patients was complete remission achieved; either partial remission or clinical improvement was achieved in 52 percent, but the duration of response was short. The response rate was 77 ...

In active noise control (ANC), there is still room for further improvement in at least two directions: (1) how to use a finite impulse response (FIR) filter to suppress noise in a resonant field with infinite impulse response (IIR) paths; and (2) how to deal with non-minimum-phase (NMP) secondary paths. A new ANC configuration is proposed here. If the ...

The influence of homework experiences on students' academic grades was studied with 223 college students. Students' self-efficacy for learning and perceived responsibility beliefs were included as mediating variables in this research. The students' homework influenced their achievement indirectly via these two self-regulatory beliefs as well as directly. ...

Eighteen patients with advanced non-Hodgkin's lymphoma other than the diffuse histiocytic type were treated with a combination of adriamycin, vincristine, ifosfamide and prednisolone (AVIP). The objective response rate was 83% (15/18); 61% (11/18) achieved complete remission. The median duration of complete ...

Chronic myeloid leukaemia (CML) patients in chronic phase (CP) are currently treated with a standard dose of imatinib of 400mg/daily. However, once in complete cytogenetic remission (CCR) it is possible that some patients maintain this status with reduced dose of the drug. Here, we describe five cases of CML in late CP, which were switched to imatinib while in CCR after ...

BACKGROUND: Despite medical therapy, 30% of patients with ulcerative colitis (UC) need to undergo surgery. Around 50% of patients with proctocolectomy with ileal pouch-anal anastomosis (IPAA) develop complications of the pouch. Clinical evidence for the use of infliximab (IFX) in refractory pouchitis is limited. The aim of this study was to report efficacy of IFX in these patients. METHODS: A ...

Achieving remission in children with steroid-resistant nephrotic syndrome (SRNS) could be difficult. Many immunosuppressive drugs are used with variable success rates. We have studied the response of children with SRNS who presented to our pediatric's renal unit between 2002 and 2007 to various modalities of therapy. We included patients with no ...

nformation they wish to locate and extract. Real IE applications must allow users to specify the nature of the information structures they desire while shielding them from the details of how the system locates new structures. Assuming users specify their information needs by providing examples, there is a natural tension between two criteria of coverage and responsiveness. ...

The present study examined the effectiveness of two different school-home notes for increasing academic productivity and appropriate classroom behavior in five inattentive children. Using an alternating treatments design, students received a school-home note with or without response cost. Both notes required teachers to evaluate students and required parents to provide ...

A 75-year-old man was admitted to our hospital with liver dysfunction and elevated C-reactive protein level. He was diagnosed with renal tumor by ultrasonography. Computed tomography revealed a renal cell carcinoma (cT3aN0M0) with Stauffer syndrome. Laparoscopic radical nephrectomy was performed. Histological findings indicated clear cell carcinoma with a sarcomatoid component. After 1 month, lung ...

This is a prospective, randomized study of 431 patients with palpable thyroid nodules who had previous radiotherapy for benign disorders of the head and neck area to determine the response of the thyroid nodules to suppressive therapy and the incidence of thyroid cancer in patients who could not be suppressed and had surgery. A complete ...

We report the case of a primary nasopharyngeal interdigitating dendritic cell tumor (IDDCT). A 25-year old male presented with bilateral decreased hearing, double vision, and ataxia. Flexible nasopharyngoscopy reviewed a large mass obstructing and filling the entire nasopharynx. MRI and PET-CT confirmed the presence of the primary tumor and demonstrated bilateral cervical lymphadenopathy. Biopsy ...

We report the case of a primary nasopharyngeal interdigitating dendritic cell tumor (IDDCT). A 25-year old male presented with bilateral decreased hearing, double vision, and ataxia. Flexible nasopharyngoscopy reviewed a large mass obstructing and filling the entire nasopharynx. MRI and PET-CT confirmed the presence of the primary tumor and demonstrated bilateral cervical lymphadenopathy. Biopsy ...

Twenty-seven previously untreated patients with favorable prognosis non-Hodgkin's lymphoma were treated with a combination of total body irradiation followed by cyclophosphamide - vincristine - prednisone (CVP). The dose of total body irradiation was planned to be 150 rad followed by 6 cycles of chemotherapy. The complete response rate was 59%; ...

Migraineurs often do not use acute migraine-specific medications. Patient-reported satisfaction with triptans is modest. Patients are generally interested in obtaining more rapid and complete symptom relief. The role of trigeminal vascular activation may explain why some patients fail to respond to current treatment. Novel formulations of currently available acute migraine ...

This Annual Report to the Congress describes the Department of Energy's activities in response to formal recommendations and other interactions with the Defense Nuclear Facilities Safety Board. During 2000, the Department completed its implementation and proposed closure of one Board recommendation and completed all ...

SM-11355 is a platinum complex developed to treat hepatocellular carcinoma (HCC). It is administered via the hepatic artery, using a carrier, lipiodol, that consists of ethyl esters of iodized poppy seed oil. We have performed a phase I clinical trial of an SM-11355-lipiodol formulation in 11 HCC patients, in order to investigate the maximum allowable dose and to maximize the efficacy and safety ...

While current literature provides evidence that imatinib mesylate has significant activity in patients with advanced and metastatic gastrointestinal stromal tumour (GIST), and highlights the potential for the development of anticancer drugs based on specific molecular abnormalities present in cancers, specific recommendations concerning the optimal duration of therapy remain controversial. This ...

ObjectiveTo investigate responsiveness according to whether patients satisfy eligibility criteria from randomized controlled trials of tumor necrosis factor (TNF) antagonists in a multi-centered United States cohortMethodsBiologic-na�ve rheumatoid arthritis patients prescribed TNF antagonists (n=465) in the Consortium of Rheumatology Researchers of North America registry ...

BackgroundSubcutaneous injections of anti-CD20 antibodies may offer benefits to both patients and the healthcare system for treatment of B-cell malignancies.Design and MethodsA pilot study was undertaken to evaluate the potential for subcutaneous dosing with 2^nd generation anti-CD20 antibody veltuzumab in patients with CD20⁺ indolent non-Hodgkin�s ...

Formative assessment feedback is increasingly viewed as essential to learning. Yet, existing studies on feedback have focused heavily on knowledge of results (KR) feedback rather than information-rich formative assessment feedback that is more commonly used to encourage and guide learning. This study was designed to investigate the effects of information-rich formative assessment feedback on ...

Concomitant administration of radiotherapy with cisplatin or radiotherapy with cetuximab appear to be the treatment of choice for patients with locally advanced head and neck cancer. In the present retrospective analysis, we investigated the predictive role of several biomarkers in an unselected cohort of patients treated with concomitant radiotherapy, weekly cisplatin, and cetuximab (CCRT). We ...

Objectives:To evaluate the effectiveness of adalimumab in patients with psoriatic arthritis (PsA) and identify predictors of good clinical response for joint and skin lesions.Methods:Patients received adalimumab 40 mg every other week in addition to standard therapy in this prospective, 12-week, open-label, uncontrolled study. Four definitions of good clinical ...

Between December 1983 and December 1987, there were 44 patients with bulky, nonresectable squamous cell carcinomas of the gynecologic tract (cervix, 36; vagina, eight) who were treated with concomitant chemotherapy and radiotherapy. Chemotherapy consisted of 5-fluorouracil (5-FU) 1g/m2 given by continuous intravenous infusion on days 1 through 4 and mitomycin C 10 mg/m2 given intravenously on day ...

A long-term public health goal in the United States involves convincing adolescents to postpone sexual activity or promote responsible sexual activity. This study investigated the effect of using infant simulators on sexuality, child care attitudes and knowledge with a sample of 309 high school students from seven different states. The treatment group included 152 students and ...

This report presents a case of highly advanced gastric cancer that achieved a histologically complete response (CR) to preoperative chemoradiotherapy with S-1 plus low-dose Cisplatin. A 60-year-old male patient underwent FDG positron emission tomography (PET) during a routine health examination. The patient was found to have swollen ...

This report presents a case of highly advanced gastric cancer that achieved a histologically complete response (CR) to preoperative chemoradiotherapy with S-1 plus low-dose Cisplatin. A 60-year-old male patient underwent FDG positron emission tomography (PET) during a routine health examination. The patient was found to have swollen ...

Objective. To assess the impact of computer-based simulation on the achievement of student learning outcomes during mannequin-based simulation.Design. Participants were randomly assigned to rapid response teams of 5-6 students and then teams were randomly assigned to either a group that completed either computer-based or ...

Objective. To assess the impact of computer-based simulation on the achievement of student learning outcomes during mannequin-based simulation.Design. Participants were randomly assigned to rapid response teams of 5-6 students and then teams were randomly assigned to either a group that completed either computer-based or ...

OBJECTIVES: In the long gonadotropin-releasing hormone agonist (GnRHa) protocols, stimulation is delayed until complete pituitary-ovarian suppression has been achieved, which usually takes a minimum of 10 days. In women who do not achieve timely suppression we set out to evaluate if prolonging GnRHa affects the results of the IVF ...

BackgroundThis study aimed to evaluate acute major toxicities, the response rate, 3-year overall survival and progression-free survival rate of locally advanced nasopharyngeal carcinoma patients on concurrent carboplatin chemoradiotherapy followed by carboplatin and 5-fluorouracil.MethodsA prospective study of fifty patients diagnosed with locally advanced nasopharyngeal ...

Sep 1, 2011 ... Title: Survey responses from Region 5: Are we achieving the public's objectives for forests and rangelands? Author: Lybecker, Donna L., ...

... Accession Number : AD0752988. Title : Distraction, Response Mode, Anxiety, and Achievement in CAI. Descriptive Note : Technical memo.,. ...

In primary central nervous system lymphoma (PCNSL), 2 international prognostic scores have been developed to estimate the outcome according to certain �prognostic groups�. However, these scores do not predict the individual course of a single patient under therapy. In this analysis, we addressed the question of whether early tumor remission in patients still under therapy, according to ...

The purpose of this study was to investigate the possible relationship between the level of implementation of the middle school concept and student achievement.

Forty high school students participated in a study to investigate learning and remembering from physics instruction. At pretest, students received aptitude tests, an alternate form of achievement test (counterbalanced) and a word association (WA) test. Then the 40 students were divided into instruction (N = 28) and control (N = 12) groups. The control group received all ...

BackgroundCurrent standard therapy commonly followed for chronic Hepatitis C Virus (HCV) in Pakistan is interferon alpha plus ribavirin combination therapy (IFN ?/ribavirin) and pegylated interferon plus ribavirin (PegIFN/ribavirin). PegIFN/ribavirin has increased rate of sustained virological response than standard IFN ?/ribavirin therapy. Objective of current study was to ...

Responsiveness of neck nodes to induction chemotherapy often differs from that of the primary tumour. We have conducted a retrospective study to evaluate the results of treating the neck in a cohort of 350 patients with locally advanced (T3-4) head and neck carcinomas treated with radiation therapy at the primary location of the tumour after induction chemotherapy. One hundred ...

We report a case of advanced upper gingival carcinoma with a contralateral metastatic lymph node invading the maxillary sinus (T4aN2cM0). An 83-year-old man was treated concurrently with chemoradiotherapy and S-1. S-1 (80 mg/body/day) was administered for 2 weeks followed by a 1-week rest period as one course. Radiation therapy involved a total of 60 Gy (2 Gy/day; 5 days/week). There were side ...

Background Bortezomib belongs to a new class of anti-cancer agents, the proteasome inhibitors, and has documented activity in multiple myeloma and mantle cell lymphoma. Preclinical studies suggest that bortezomib has synergistic activity with rituximab, which provides a rationale for the exploration of treatment combinations. DESIGN AND METHODS: The activity and safety of bortezomib in combination ...

BackgroundBortezomib belongs to a new class of anti-cancer agents, the proteasome inhibitors, and has documented activity in multiple myeloma and mantle cell lymphoma. Preclinical studies suggest that bortezomib has synergistic activity with rituximab, which provides a rationale for the exploration of treatment combinations.Design and MethodsThe activity and safety of bortezomib in combination ...

Although imatinib induces marked responses in patients with chronic myeloid leukemia (CML), resistance is increasingly problematic, and treatment options for imatinib-resistant or -intolerant CML are limited. Dasatinib, a novel, highly potent, oral, multitargeted kinase inhibitor of BCR-ABL and SRC family kinases, induced cytogenetic responses in a phase 1 ...

A study examined students' metacognitive response to ambiguous literacy tasks to determine the relationship between that response and academic achievement. Subjects were 11 students chosen from a fifth-grade classroom in a small, urban school serving a predominantly black, middle class neighborhood. Two literacy tasks were identified ...

BackgroundImatinib is the standard of care for newly diagnosed chronic-phase chronic myeloid leukemia. The largest randomized clinical trial of imatinib was the multinational IRIS trial in which 1106 patients were randomized to receive either imatinib 400 mg/day or a standard regimen of interferon-? plus cytarabine.Design and MethodsPatients were allowed to cross over to the opposite treatment for ...

Treatment of invasive prolactinoma, which has several characteristics including invasive growth into cavernous sinuses and formation of giant adenomas compressing adjacent neural structures, resulting in neurological dysfunction, has been very challenging. There are relatively few reports available describing long-term treatment outcome. Herein, we document the results of bromocriptine ...

With the right mix of leadership and policy, a completely renewable electricity sector for New Zealand and the United States is feasible, achievable, and desirable. (author)

... possible approach to prevention may be to develop strategies that achieve complete involution as early as possible after childbearing is completed. ...

We investigate the time-domain tilt response of an electrostatically actuated mechanical microoscillator positioned at a liquid-liquid interface. An analytical model is presented to simulate the microoscillator's rotational motion inside a microchannel completely filled with two immiscible liquids. The model considers two coupled ordinary differential ...

A saline solution of bovine serum albumin (40 mg/kg) readily stimulated the production of precipitins and passive haemagglutinating (HA) antibodies in adult chickens and pheasants, but not in quail, following a primary (day 0) and secondary (day 38) intravenous injection. In quail a primary injection of BSA in Freund's complete adjuvant produced low passive HA titres but not ...

The ability of systemic immunization to induce protection against Helicobacter pylori infection has been evaluated in a mouse model. It was observed that if appropriate formulations and adjuvants were used such immunization elicited in outbred Swiss mice levels of protection similar or better than those induced by the oral route in the presence of cholera toxin or Escherichia coli heat labile ...

Self-assembly of colloidal particles in the liquid interface of double emulsion droplets can be used to fabricate "colloidosome" microcapsules, which have great potential as vehicles for the controlled delivery of drugs or other cargoes. Here we present a novel class of aqueous core colloidosomes that combine the benefit of low capsule permeability (good cargo retention) with the option of a ...

The complete electromagnetic responses from conducting objects in time and frequency domains are generated by using their early time and low frequency information. Utilizing two kinds of Hermite polynomials and their Fourier transform, the time-domain signal and its corresponding frequency response can be expressed as a weighted sum of ...

Chronic eosinophilic leucemia (CEL) is a very rare form of leucemia in the western world. Adequate response is seldomly achieved after treatment with corticosteroids, interferon-alfa (INF-alfa) and medications containing hydroxi-urea (Litalir). The study presents a patient with CEL with no initial therapeutic response to the use of ...

One hundred and eight patients with squamous cell carcinoma of the upper aerodigestive tract (UADT) (T3, T4, NO-N3; 17% stage II, 54% stage III, 27% stage IV) were given three courses of chemotherapy before any local treatment. The regimen consisted of cis-platinum 100 mg m-2 on day 1 and 5-fluorouracil 1000 mg m-2 on days 2-6; drugs were administered by continuous infusion. The toxicity of this ...

... and maintaining the data needed, and completing and reviewing this collection ... the new Global Defense Posture Review is complete. ... APOD APOE ...

... If not an approval, the action letter contained a complete list of deficiencies in the application and completed the review cycle for the application. ...

The patient was a 63-year-old female, who was admitted to the National Nagoya Hospital with complaints of left cervical and bilateral axillary lymphadenopathy on 12 May, 1987. Since May 1985, with the diagnosis of non-Hodgkin lymphoma, she had been successfully treated with combination chemotherapy (VEPA) and radiotherapy at another hospital. Left axillary lymphode biopsy revealed a diagnosis of ...

The authors report studies of oncogene transcription induced by the addition of serum to quiescent cultures of human IMR-90 fibroblasts. Oncogene messenger RNAs for c-myc, c-erbB and c-ras were increased in a specific temporal sequence after the addition of serum. Compounds that are proposed to exert their actions by the stimulation of cell growth were tested for their effect on oncogene ...

As part of the ongoing international DECOVALEX project, four research teams used five different models to simulate coupled thermal, hydrological, and mechanical (THM) processes near waste emplacement drifts of geological nuclear waste repositories. The simulations were conducted for two generic repository types, one with open and the other with back-filled repository drifts, under higher and lower ...

As part of the ongoing international DECOVALEX project, four research teams used five different models to simulate coupled thermal, hydrological, and mechanical (THM) processes near waste emplacement drifts of geological nuclear waste repositories. The simulations were conducted for two generic repository types, one with open and the other with back-filled repository drifts, under higher and lower ...

Objective. A combination of intravenous clindamycin and oral tetracycline has been used for many years as a treatment for active rheumatoid arthritis (RA), despite the absence of good evidence for its efficacy. A single-blind pilot study of this therapy suggested that a double-blind placebo-controlled trial was warranted. Methods. Patients with active RA were randomised in a 2?:?1 ratio to ...

As part of the ongoing international DECOVALEX project, four research teams used five different models to simulate coupled thermal, hydrological, and mechanical (THM) processes near underground waste emplacement drifts. The simulations were conducted for two generic repository types, one with open and the other with back-filled repository drifts, under higher and lower post-closure temperature, ...

In this article, the authors discuss ways ecobehavioral assessment (EBA) has contributed to greater understanding of students' response to instructional intervention and its relationship to academic learning and achievement. EBA represents a proven effective way to conduct a contextual analysis of the instructional environments, teacher and student ...

Detailed studies of the photosexual biology of male European starlings ( Sturnus vulgaris) document a non-obligatory involvement of photoperiod in the induction of testicular metamorphosis. Although post-winter solstice increases in daily photophase duration are responsible for the ecologically correct chronology of the annual reproductive cycle, starlings maintained in the ...

The complexity of the therapeutic approach in lupus nephritis (LN) is increased by the large number of patients who do not respond to first-line therapies and by relapses after initial clinical remission. The emergence of biological agents has increased the therapeutic armamentarium available in these complex situations, but their use is limited by the lack of licensing. We analysed current ...

Adult T-cell leukemia (ATL) is a highly chemoresistant and usually fatal T-cell malignancy due to the human T-cell lymphotropic virus-1 (HTLV-1). After chemotherapy failure, antiretrovirals and interferon-? (IFN-?) produce brief responses followed by progression and death. More effective agents and new approaches to detect and treat minimal residual disease are needed. ATL ...

Twenty patients with refractory malignant lymphoma were treated with a combination of VP-16, ifosfamide, procarbazine, prednisolone, bleomycin and methotrexate (VIPP-BM) as salvage chemotherapy. These patients were either resistant to front-line therapy or refractory in their relapses. Two patients (10%) achieved a complete remission and eleven patients ...

Polarization smoothing (PS) is the illumination of the target with two distinct and orthogonally polarized speckle patterns. Since these two polarizations do not interfere, the intensity patterns add incoherently and thus the contrast of the intensity nonuniformity can be reduced by a factor of {radical}2 in addition to any reduction achieved by temporal smoothing techniques. ...

This article puts forward the case for introducing sustainability in the NHS and the associated benefits in terms of healthcare promotion, reducing negative environmental impact, achieving efficiency savings, and positive social and community values. How to introduce sustainability effectively in the changing NHS landscape is addressed and argument put forward for partnership ...

We consider the effects of acoustic pressure on the curing of a two-part epoxy, which can be considered analogous to the polymer healing process. An epoxy sample is loaded into a tube and monitored throughout the curing process by measuring the amplitudes of its natural frequencies in response to periodic mechanical impulses. The progress of the curing process can be ...

The AIDS epidemic continues to advance, and the development of a preventive HIV vaccine has become a major objective for scientific research. An effective vaccine against this virus is not available and complete protection still has not been achieved in animal models. In this review the major challenges related to the development of a vaccine against HIV ...

Delivery of continous low-dose-rate radiation at a constant rate using an afterloading plastic helmet system can achieve the local cure of the BA1112 rat sarcoma. Complete dose response curves for local tumor cure have been obtained at 170 rad (1.7 Gy) and 130 rad (1.3 Gy) per hour. The results are consistent with the known ...

A retrospective survey of the records of 287 patients with generalised myasthenia gravis treated at New End Hospital and later at the Royal Free Hospital by anticholinesterase drugs, with or without thymectomy, between the years 1942 and 1976, shows that 62% of patients were improved. The timing of the operation, the grading of disease and the age and sex of the patient did not greatly influence ...

The European Spallation Source (ESS), which will be built in the south of Sweden, uses a 5MW proton beam from a 2.5GeV superconducting linac. When completed, it will be the world's most powerful cold neutron source. The ESS has set the objective to be carbon neutral and as energy efficient as possible. This will be achieved in part by energy saving ...

The E864 experiment is a large acceptance forward spectrometer designed to search for exotic composite objects potentially produced in relativistic Au+Pb collisions at the Brookhaven AGS. In order to detect such particles a very sensitive mass spectrometer is required. To achieve the required level of sensitivity the E864 hadronic calorimeter must supply an independent ...

The Integrated Stationary Evacuated Concentrator or ISEC solar collector has achieved the best high temperature performance ever measured with a stationary collector. A development program to carry out a design review of the initial proof of concept configuration has been completed. Changes in the optical design to improve the angular ...

The authors present several designs for VLSI dictionary machines that combine both a linear (modify) network and a logarithmic (query) network with a novel idea for separation of concerns. The authors' initial design objectives included: single-cycle operability of host-issued modify and query commands (no compress instructions), complete processor utilization (no ...

A serial crate controller, primarily for use in the SLC CAMAC control system, has been designed, and has been in use for about 2 years. The design supports a party line approach, with up to 16 crates on a single twisted pair for data transfers, plus another pair for prompt L response. The bit rate is 5 megabits/s, and complete transaction times of about 10 ...

A real-time polarization control system employing two nonorthogonal reference signals multiplexed in either time or wavelength with the data signal is presented. It is shown, theoretically and experimentally, that complete control of multiple polarization states can be attained employing polarization controllers in closed-loop configuration. Experimental results show that ...

The Integrated Stationary Evacuated Concentrator or ISEC solar collector panel has achieved the best high temperature performances ever measured with a stationary collector. A development effort to carry out a review and optimization of the initial proof of concept design is nearing completion. Changes in the optical design to improve the angular ...

Twelve consecutive patients with advanced stage mycosis fungoides (MF) were treated with combined total body X ray irradiation (TBI) and total skin electron beam radiotherapy (EBRT). Six had generalized plaque disease and dermatopathic nodes, three had tumor stage disease and node biopsy positive for mycosis fungoides, and three had erythroderma/Sezary syndrome. The treatment regimen consisted of ...

Approximately 70% to 80% of patients with newly diagnosed bladder cancer will present with superficial bladder tumors (i.e., stage Ta, Tis, or T1). Those who do present with superficial, noninvasive bladder cancer can often be cured, and those with deeply invasive disease can sometimes be cured by surgery, radiation therapy, or a combination of modalities that include chemotherapy. Studies have ...

Clinical and experimental data suggest a synergistic antitumoral effect with the combined treatment of radiotherapy and 5-fluorouracil (5-FU) serving as a radiosensitizer. This combined modality was studied in 30 malignant melanoma patients with advanced locoregional or isolated, bulky, soft-tissue or visceral metastases. All patients were symptomatic, pain being the chief complaint, followed by ...

Purpose: The aim of this study was to determine the efficacy of capecitabine (Xeloda (registered) ), an oral fluoropyrimidine, as a radiosensitizer in the neoadjuvant treatment of locally advanced rectal cancer (LARC). Methods and Materials: We conducted a phase II study of capecitabine (825 mg/m{sup 2} orally, twice daily continuous) with radiotherapy (52.5 Gy/30 fractions to the primary tumor ...

... to optimize a specified one of these response surface functions subject to the conditions that the others achieve certain desired activity levels. ...

... Title : Effect of Anxiety, Response Mode, and Subject Matter Familiarity on Achievement in Computer-Assisted Learning. ...

Purpose: Although concurrent chemoradiotherapy can now achieve demonstrated long-term survival in patients with locally advanced non-small-cell lung cancer (LANSCLC), it is difficult to predict which patients will benefit most from this therapeutic approach. Studies have suggested that local control, and the response to therapy, may be linked to improved ...

The aim of this phase IV study was to (1) to define efficacy of escalating dose imatinib in chronic myeloid leukemia (CML) patients showing suboptimal response to standard dose imatinib and (2) to find markers that predict the response to escalating doses of imatinib. CML patients in chronic phase (CP) who failed to achieve optimal ...

The results of combined interferon alfacon-1 and ribavirin therapy of 94 patients with chronic hepatitis C were analyzed. Complete data, including sustained viral response (SVR), were obtained in 88 patients. 46.8% of them achieved SVR. The most important factor influencing SVR, was the presence of HCV RNA in serum at weeks 12 and 24 ...

The purpose of this study was to examine the effects of testing on the achievement of students using self-instructional materials to learn science process skills. In one section of an undergraduate science method class, students were paced through a programmed textbook and were given short quizzes in class after each of the process skill lessons was assigned, while in another ...

Graves (2005) suggested that academic freedom might impede efforts to improve institutional performance and achieve the goals set for learning outcomes, cost efficiency, and preparing students for the workplace. The author's initial response to threats to academic freedom and calls for efficiency is to bristle, because he views these as threats to the very ...

A viscous water base, non-Newtonian fracturing fluid has been used to successfully stimulate 7 Wilcox (upper Eocene) and 2 Vicksburg (lower Oligocene) gas wells. An average gas production increase of 2.8 MMcfd was achieved as compared to 0.7 MMcfd for treatments performed on similar completions with treated low-viscosity fluids. The principal application ...

BACKGROUND: Extremely rapid movements are frequently executed in response to novel, potentially threatening stimuli. The mechanism by which these sophisticated responses are generated is a topic of debate. The current study investigates: 1) the importance of stimulus-response congruence in rapid responses and 2) ...

Between June 1998 and August 2000, five patients with germ cell tumor were treated with high-dose CEI: carboplatin (1,250 mg/m2), etoposide (1,500 mg/m2), and ifosfamide (7.5 g/m2), followed by peripheral blood stem cell transplantation (PBSCT) at Yokohama City University Hospital. All patients were classified into either poor risk group of International Germ Cell Consensus Classification or ...

... No; FDA has been issuing complete response letters for all products for which marketing approval is sought under a biologics license application since 1998. ...

... the following (and these must be documented completely): hearing status; developmental landmarks achieved and at what age; if in school, learning or reading ...

Auxiliary Power for contingency operation of IPS (retrac- ...... ty is among others achieved by a completely redundant retrac- ...

... is widely utilized for grid generation [9]. The control of the characteristics and distribution of a grid system can be achieved by varying the values of ...

... is applicable to integrated systems that achieve ... competing functions on system reliability. ... Completion Success Probability, and Failure Resiliency. ...

The four "windows" below provide a mechanism for assessing the level of understanding which the student has achieved upon completing the activities and ...

... In contingent EBL, deferred goals are represented using conjectured variables, which act as placeholders for the eventual values of plan ...

... given a certificate of completion of achievement. ... on a rigorous competitive academic basis for ... prostate disease among African American men that ...

... In order for the hook- up wire to be completely waterproof, the potting ... To achieve true waterproofing of potted electrical connectors the potting must ...

... to combined creep and thermal cycling loadings, the main achievements in the experimental study are: completion of a new thermal cycles with ...

... Complete kill of Bacillus subtilis spores was achieved in 70% of the experimental samples; again no sporicidal activity was observed in the control ...

The National Ignition Facility (NIF) is a MJ-class glass laser-based facility funded by the Department of Energy which has achieving thermonuclear ignition and moderate gain as one of its main objectives. In the summer of 1998, the project is about 40% complete, and design and construction is on schedule and on cost. The NIF will start firing onto targets ...

The National Ignition Facility (NIF) is a MJ-class glass laser-based facility funded by the Department of Energy which has achieving thermonuclear ignition and moderate gain as one of its main objectives. In the summer of 1998, the project is about 40% complete, and design and construction is on schedule and on cost. The NIF will start firing onto targets ...

This study investigated factors related to Taiwanese senior high school students' self-esteem. A total of 1,672 students (779 boys, 893 girls) in Kaohsiung City in Taiwan completed a Chinese version of the Secondary Student Questionnaire (SSQ; Z. Hong, 2001). In addition, interviews were conducted with six students from three different high schools (high, moderate, and low ...

The aim of the present study is to explore a causal model of academic achievement and learning-related personal variables by testing the nature of relationships between learned hopelessness, its risk factors and hopelessness deficits as proposed in major theories in this area. The model investigates affective-motivational characteristics of students such as prior academic ...

ABSTRACT Background. It has not been clearly established whether second generation tyrosine kinase inhibitors actually improve the survival of chronic phase chronic myeloid leukaemia patients who fail imatinib and then receive nilotinib or dasatinib. Design and Methods. To address this issue we compared the survival of 104 patients who failed imatinib as first line therapy and then were treated ...

Purpose: To evaluate the locoregional efficacy of multimodality treatment for breast cancer patients who present with ipsilateral supraclavicular (SCV) disease without systemic metastases. Methods: We retrospectively reviewed the data from 71 patients with ipsilateral SCV involvement at presentation. SCV involvement in 16 patients (23%) was diagnosed by ultrasound examination only, without ...

We investigated the patterns of pretreatment expression of the epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and cyclooxygenase-2 (COX-2) by immunohistochemical staining and determined their correlation with treatment response and survival in 44 patients with esophageal squamous cell carcinoma (ESCC) treated with definitive concurrent ...

Tolerance induction to prevent activation of a na�ve T-cell repertoire has been well documented in rodents and can be readily achieved by intravenous, oral or intranasal administration of antigen in the absence of adjuvants. In autoimmune diseases such as multiple sclerosis (MS) the presence of an established memory/effector T-cell repertoire against self-antigens is likely ...

Tolerance induction to prevent activation of a na�ve T-cell repertoire has been well documented in rodents and can be readily achieved by intravenous, oral or intranasal administration of antigen in the absence of adjuvants. In autoimmune diseases such as multiple sclerosis (MS) the presence of an established memory/effector T-cell repertoire against self-antigens is likely ...

Doxorubicin was initially administered alone by continuous infusion for 5 days every 3 weeks in escalating doses to 13 patients with advanced metastatic and/or recurrent malignancies. The maximum tolerable dosage was 13 mg/m2 per day for 5 days. Kinetic data showed a steady level of 60 ng/ml for 4 days and a biphasic disappearance curve. Radiation therapy (150-200 cGy per session) was then ...

Bryostatin 1, isolated from a marine bryozoan, enhances the efficacy of cytotoxic agents through modulation of the protein kinase C pathway and is active in combination with vincristine for diffuse large B-cell lymphoma. Further, the apoptotic frequency of peripheral blood T lymphocytes as determined by flow cytometry may predict which patients will respond to this combination. We tested the ...

From 1977-1982, 161 patients were treated using hyperthermia as an adjuvant in Phase I trials. Microwave applicators (MW), capacitively coupled plates (RF plates), interstitial localized current fields (LCF), and magnetic induction heating (MI) techniques were used together with radiation in 135 patients, with chemotherapy in 10 patients, and alone in 16 patients. Tumor volume ...

This report reviews clinical experience with high-dose chemotherapy with stem-cell support in breast cancer and attempts to integrate clinical and molecular biological observations into a model of drug resistance. Despite the remarkable initial chemosensitivity of breast cancer, the majority of patients with advanced breast cancer die of their disease. In trials to date, high-dose chemotherapy has ...

The purpose of this work is to better define thermal parameters related to tumor response in superficial malignancies treated with combined hyperthermia and radiation therapy. Patients were randomized to receive one or two hyperthermia treatments per week with hyperthermia given during each week of irradiation. Hyperthermia was given for 60 min with treatments begun within 1 ...