THE modification of the effect of radiation on a murine ascitic tumour irradiated in vivo by pharmacological agents has been previously reported1-3. In those investigations the effect of radiation on the reproductive capacity of ascitic tumour cells was modified by direct injection of the pharmacological agent into ...

moment during walking and stair climbing in pain free individuals with knee osteoarthritis," Gait option for patients with medial compartment knee osteoarthritis. If proven effective for offloading achieve sufficient pain relief through pharmacological means and yet are too young to receive a total knee

... of effects of experimentally-produced gastric lesions on ... PHARMACOLOGY, STIMULATION(PHYSIOLOGY), ULCERS, SECRETION, STOMACH. ...

ABSTRACTOBJECTIVETo review the evidence on the efficacy and safety of pharmacologic and nonpharmacologic therapies for smoking cessation.QUALITY OF EVIDENCEMEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews were searched for randomized controlled trials, meta-analyses, and systematic reviews (level I evidence) pertinent to pharmacologic and ...

From first international conference on stable isotopes in chemistry, biology, and medicine; Argonne, Illinois, USA (9 May 1973). In proceedings of the first international conference on stable isotopes in chemistry, biology, and medicine. Pharmacology and clinical pharmacology suffer from a lack of rigorous structural and quantitative information ...

Diabetic foot ulcers are the most common lower extremity complications of diabetes. Peripheral neuropathy and peripheral vascular disease are the underlying risk factors for diabetic foot ulcers, subsequently leading to infections and requiring antimicrobial therapy for the management of the disease. Each risk factor is a target for clinical intervention, with the intent to delay or prevent ...

... Title : Effects of Pharmacologic Intervention on Oxygenation, Lung Water and Protein Leak in the Pseudomonas ARDS Porcine Model. ...

Although numerous programs have been developed for Grade Kindergarten through 12 science education, evaluation has been difficult owing to the inherent problems conducting controlled experiments in the typical classroom. Using a rigorous experimental design, we developed and tested a novel program containing a series of pharmacology modules (e.g., drug abuse) to help high ...

Using an analogued labor pain procedure, the efficacy of combinations of five cognitive and one pharmacologic approach to pain management was examined. Nulliparous undergraduates (N = 120) were randomly assigned to 1 of 12 groups. Cognitive groups included: systematic desensitization (SYS DENS); sensory description (SEN DESC); sensory transformation (ST); modeling (M); and ...

BackgroundTargeted delivery of pharmaceutical agents into selected populations of CNS (Central Nervous System) neurons is an extremely compelling goal. Currently, systemic methods are generally used for delivery of pain medications, anti-virals for treatment of dermatomal infections, anti-spasmodics, and neuroprotectants. Systemic side effects or undesirable ...

... Title : Pharmacology of New Antimalarial Drugs: Cardiopulmonary Effects of Phenanthrenemethanols: WR 33,063 and NIH 204. ...

The report contains a review of world literature and analyzes the effect of various groups of pharmacological agents on behavior and different stages of memory.

... Title : PHARMACOLOGICAL STUDIES ON IRRADIATED ANIMALS. X. EFFECTS OF CELL-FREE SPLEEN EXTRACT TREATMENT ON ...

Pharmacotherapy can provide effective treatment of tobacco dependence and withdrawal, and thereby facilitate efforts to achieve and sustain tobacco abstinence. Currently approved medications for smoking cessation are nicotine replacement medications (NRT), including nicotine patch, gum, lozenge, sublingual tablet, inhaler and nasal spray, the ...

Changes in pharmacology teaching are being driven by various pressures. These originate: from changes in the discipline itself; from government; from professional bodies; from students; from changes in teaching styles and opportunities; from academic staff; from ethical/animal rights considerations; from employers and from higher education institutions. These changes will ...

Snake venoms are an extremely rich source of pharmacologically active proteins with a considerable clinical and medical potential. To date, this potential has not been fully explored, mainly because of our incomplete knowledge of the venom proteome and the pharmacological properties of its components, in particular those devoid of enzymatic activity. This ...

Pharmacological vasodilatation with either dipyridamole or adenosine is a safe and accurate alternative to exercise testing to diagnose coronary artery disease with thallium 201 myocardial perfusion imaging. The technique also provides important prognostic information with regard to future cardiac events in patients undergoing diagnostic testing, in those evaluated ...

Many clinicians frequently face the dilemma of whether and how to medically treat spasticity. When pharmacologic intervention is deemed appropriate, treatment decisions must first be based on accurate assessment using valid and reliable clinical instruments, and, importantly, specific, measurable, achievable, and realistic treatment goals should be ...

Pharmacologic effects in brain caused by systemic administration of neuropeptides are prevented by poor transport of the peptide through the brain vascular endothelium, which comprises the blood-brain barrier in vivo. In the present study, successful application of a chimeric peptide approach to enhance drug delivery through the blood-brain barrier for the ...

110 Graduate Student Achievements 09-10 PHARMACOLOGICAL SCIENCES GRADUATE DIRECTOR: STYLIANI der Kloot Award for excellence in research, $500. Molecular and Cellular Pharmacology Graduate Program of Pharmacological Sciences, Stony Brook University, Stony Brook, NY. Yao, Yao. (2010) Sigma Xi Travel Award, $150

Panic disorder (PD) is a disabling condition which appears in late adolescence or early adulthood and affects more frequently women than men. PD is frequently characterized by recurrences and sometimes by a chronic course and, therefore, most patients require long-term treatments to achieve remission, to prevent relapse and to reduce the risks associated with comorbidity. ...

Major depressive disorder is complicated and difficult to treat, primarily because of its chronic and recurrent nature and the poor efficacy of most pharmacologic treatment options. Until more effective treatments become available, clinicians must focus on optimizing patient outcomes through patient care. Implementing measurement-based care and using ...

... Descriptors : *PHARMACOLOGICAL ANTAGONISTS, *DIURETICS, PHYSIOLOGICAL EFFECTS, HIGH ALTITUDE, CARDIOVASCULAR SYSTEM ...

The development of anti-hypertensive therapy and its achievements over the last 40 years are reviewed. The following are identified as the still unanswered questions: the pharmacological treatment of mild hypertension; the limited efficacy of anti-hypertensive therapy in the reduction of the number of myocardial infarctions; the negative ...

Speech compression (spacecraft voice communication). Telemetry (spacecraft applications) ...... Pathology. " Pharmacological effects of atmospheric flight. " Pharmacological effects of space ...... as economics, sociology, ethics, etc. ...

Significant progress in understanding the pharmacological characteristics and physiological importance of homomeric and heteromeric P2X channels has been achieved in recent years. P2X channels, gated by ATP and most likely trimerically assembled from seven known P2X subunits, are present in a broad distribution of tissues and are thought to play an ...

Fibromyalgia is a chronic pain disorder characterized by widespread pain, stiffness, insomnia, fatigue and distress. Several randomized controlled trials (RCTs) have shown moderate effectiveness of pharmacological therapies for fibromyalgia pain. Evidence from these trials suggests that pharmacological therapy can not only improve pain ...

Conventional treatment approaches have had little impact on the course of pancreatic cancer, which has the highest fatality rate among cancers. Gemcitabine, the primary therapeutic agent for pancreatic carcinoma, produces minimal survival benefit as a single agent. Therefore, numerous efforts have focused on gemcitabine combination treatments. Using a ratio design, this study established that ...

Results of current research into perioperative medication errors have revealed that more than half of medication errors occur during the administration phase of the medication-use process. The administration phase is the point at which the medication and the patient intersect and the medication imposes its pharmacological effect. During this phase, the ...

One hundred years since his birth, fifty years after his Nobel achievement, Daniel Bovet still emerges as one of the key figures of both pharmacology and psychobiology, the biological and evolutionary roots of behaviour. The life and scientific activities of Daniel Bovet (1907-1992) are closely linked to the 'golden years' of ...

The pharmacological mechanisms focusing on chiral isomer of ibuprofen are not fully understood. Only the (S)-isomer of ibuprofen inhibits cyclooxygenases, which mediates the generation of prostanoids and thromboxanes. Consequently, (S)-isomers represent a major promoter of the anti-inflammatory effect, and the effects of the ...

Photodynamic therapy is a new adjunctive therapy for filtration surgery that does not use chemotherapy agents or radiation, but uses pharmacologically-active sensitizing compounds to produce a titratable, localized, transient, post operative avascular conjunctiva. A photosensitizing agent in a biological system is selectively activated by delivering the photosensitive agent to ...

The pharmacology and toxicology of salmonids are described. The authors also document territorial behavior of salmonids and their response to effects of drugs, chemicals or pollutants. Current literature is cited as the best source of information regardin...

Pharmacology and toxicology of Salmonids are described. Authors also document territorial behavior of salmonids and their response to effects of drugs, chemicals or pollutants. Current literature is cited as the best source of information regarding the use of drugs and chemicals ...

Feb 12, 2008 ... 18h, What are effective management strategies for chronic pain in reduced-G ( pharmacologic and non-pharmacologic), TBD ...

... use of quantitative drug development methods (ie, exposure ... programs should encourage clinical pharmacology and ... most efficient and effective method available to ...

Studies were carried out to determine the pharmacological activity and the metabolic fate of compound A, (CLF5). The project was planned to determine pharmacological effects by evaluation of behavioral, physical, and biochemical changes induced by adminis...

OF CLINICAL PHARMACOLOGY AND NEPHROLOGY Vacancy Reference No: 05238 Major Cost Centre: Faculty of Health Sciences Organisational Unit: Department of Clinical Pharmacology and Nephrology, School of Medicine Pharmacology and Nephrology. These trials involve the study of the effects of different treatment strategies

Berbamine (molecular formular C37H40N2O6) is a bi-benzle-isoquinolyl alkaloid extracted from Berberis poiretil Schneid (genus of Berberis, family of Beridaceae), a kind of Chinese plants. In aspect of cardiovascular pharmacology, berbamine shows actions of anti-arrhythmia, anti-myocardial ischemia, vasodilatating to lower blood pressure, and antithrombosis, it could lower ...

BackgroundThe rational prescribing of drugs is an essential skill of medical doctors. Clinical pharmacologists play an important role in the development of these skills by teaching clinical pharmacology and therapeutics (CP&T) to undergraduate medical students. Although the approaches to teaching CP&T have undergone many changes over the last decennia, it is essential ...

The study of endocannabinoid pharmacology has proceeded from the discovery of ?9-tetrahydrocannabinol, the main psychoactive compound in Cannabis sativa, to the identification of an endogenous endocannabinoid system that is essential for physiological modulation of neuronal functions. We have not yet achieved a complete understanding of the various roles ...

Optimal migraine therapy begins with an accurate diagnosis and knowledge of the symptoms that the patient finds most disturbing. Pharmacologic treatment of migraine may be acute (abortive, symptomatic) or preventive (prophylactic); both approaches are frequently required in patients with frequent, severe headaches. Drugs for acute care consist of analgesics, antiemetics, ...

... MICROWAVES, *PATHOLOGY, *PHARMACOLOGY, *RADIATION EFFECTS, BLOOD, CHICKENS, DOGS, ELECTROCARDIOGRAPHY ...

Microliter quantities of tetrodotoxin, tetraethylammonium chloride, and picrotoxin injected into the

... PSYCHOPHYSIOLOGY), BEHAVIOR, PHYSIOLOGY, PHARMACOLOGY, ELECTROPHYSIOLOGY, TRANQUILIZERS, LEARNING, MEMORY ...

... NOISE, *PHARMACOLOGY, HUMAN BODY, DOSAGE, MUSCLE RELAXANTS, PHYSIOLOGY, STRESS(PSYCHOLOGY), TRANQUILIZERS. ...