In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA Repeats.

PubMed

Figura, Grzegorz; Koscianska, Edyta; Krzyzosiak, Wlodzimierz J

2015-08-11

Polyglutamine diseases, including Huntington's disease and a number of spinocerebellar ataxias, are caused by expanded CAG repeats that are located in translated sequences of individual, functionally-unrelated genes. Only mutant proteins containing polyglutamine expansions have long been thought to be pathogenic, but recent evidence has implicated mutant transcripts containing long CAG repeats in pathogenic processes. The presence of two pathogenic factors prompted us to attempt to distinguish the effects triggered by mutant protein from those caused by mutant RNA in cellular models of polyglutamine diseases. We used the SLIP (Synthesis of Long Iterative Polynucleotide) method to generate plasmids expressing long CAG repeats (forming a hairpin structure), CAA-interrupted CAG repeats (forming multiple unstable hairpins) or pure CAA repeats (not forming any secondary structure). We successfully modified the original SLIP protocol to generate repeats of desired length starting from constructs containing short repeat tracts. We demonstrated that the SLIP method is a time- and cost-effective approach to manipulate the lengths of expanded repeat sequences.

Multidentate (18)F-polypegylated styrylpyridines as imaging agents for Aβ plaques in cerebral amyloid angiopathy (CAA).

PubMed

Zha, Zhihao; Choi, Seok Rye; Ploessl, Karl; Lieberman, Brian P; Qu, Wenchao; Hefti, Franz; Mintun, Mark; Skovronsky, Daniel; Kung, Hank F

2011-12-08

β-Amyloid plaques (Aβ plaques) in the brain are associated with cerebral amyloid angiopathy (CAA). Imaging agents that could target the Aβ plaques in the living human brain would be potentially valuable as biomarkers in patients with CAA. A new series of (18)F styrylpyridine derivatives with high molecular weights for selectively targeting Aβ plaques in the blood vessels of the brain but excluded from the brain parenchyma is reported. The styrylpyridine derivatives, 8a-c, display high binding affinities and specificity to Aβ plaques (K(i) = 2.87, 3.24, and 7.71 nM, respectively). In vitro autoradiography of [(18)F]8a shows labeling of β-amyloid plaques associated with blood vessel walls in human brain sections of subjects with CAA and also in the tissue of AD brain sections. The results suggest that [(18)F]8a may be a useful PET imaging agent for selectively detecting Aβ plaques associated with cerebral vessels in the living human brain.

Second Computational Aeroacoustics (CAA) Workshop on Benchmark Problems

NASA Technical Reports Server (NTRS)

Tam, C. K. W. (Editor); Hardin, J. C. (Editor)

1997-01-01

The proceedings of the Second Computational Aeroacoustics (CAA) Workshop on Benchmark Problems held at Florida State University are the subject of this report. For this workshop, problems arising in typical industrial applications of CAA were chosen. Comparisons between numerical solutions and exact solutions are presented where possible.

Fourth Computational Aeroacoustics (CAA) Workshop on Benchmark Problems

NASA Technical Reports Server (NTRS)

Dahl, Milo D. (Editor)

2004-01-01

This publication contains the proceedings of the Fourth Computational Aeroacoustics (CAA) Workshop on Benchmark Problems. In this workshop, as in previous workshops, the problems were devised to gauge the technological advancement of computational techniques to calculate all aspects of sound generation and propagation in air directly from the fundamental governing equations. A variety of benchmark problems have been previously solved ranging from simple geometries with idealized acoustic conditions to test the accuracy and effectiveness of computational algorithms and numerical boundary conditions; to sound radiation from a duct; to gust interaction with a cascade of airfoils; to the sound generated by a separating, turbulent viscous flow. By solving these and similar problems, workshop participants have shown the technical progress from the basic challenges to accurate CAA calculations to the solution of CAA problems of increasing complexity and difficulty. The fourth CAA workshop emphasized the application of CAA methods to the solution of realistic problems. The workshop was held at the Ohio Aerospace Institute in Cleveland, Ohio, on October 20 to 22, 2003. At that time, workshop participants presented their solutions to problems in one or more of five categories. Their solutions are presented in this proceedings along with the comparisons of their solutions to the benchmark solutions or experimental data. The five categories for the benchmark problems were as follows: Category 1:Basic Methods. The numerical computation of sound is affected by, among other issues, the choice of grid used and by the boundary conditions. Category 2:Complex Geometry. The ability to compute the sound in the presence of complex geometric surfaces is important in practical applications of CAA. Category 3:Sound Generation by Interacting With a Gust. The practical application of CAA for computing noise generated by turbomachinery involves the modeling of the noise source mechanism as a

75 FR 10503 - Notice of Lodging of Consent Decree Under the Clean Air Act

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-08

... DEPARTMENT OF JUSTICE Notice of Lodging of Consent Decree Under the Clean Air Act Notice is hereby... alleged violations of the Clean Air Act at the DEGs of Narrows, LLC facility in Narrows, Virginia. The complaint alleged that DEGs of Narrows, LLC violated the Clean Air Act, Sections 110, 112 and 502 of the CAA...

Can brain impermeable BACE1 inhibitors serve as anti-CAA medicine?

PubMed

Li, Jian-Ming; Huang, Li-Ling; Liu, Fei; Tang, Bei-Sha; Yan, Xiao-Xin

2017-08-25

Cerebral amyloid angiopathy (CAA) is characterized by the deposition of ß-amyloid peptides (Aß) in and surrounding the wall of microvasculature in the central nervous system, together with parenchymal amyloid plaques collectively referred to as cerebral amyloidosis, which occurs in the brain commonly among the elderly and more frequently in patients with Alzheimer's disease (AD). CAA is associated with vascular injury and may cause devastating neurological outcomes. No therapeutic approach is available for this lesion to date. ß-Secretase 1 (BACE1) is the enzyme initiating Aß production. Brain permeable BACE1 inhibitors targeting primarily at the parenchymal plaque pathology are currently evaluated in clinical trials. This article presents findings in support of a role of BACE1 elevation in the development of CAA, in addition to plaque pathogenesis. The rationale, feasibility, benefit and strategic issues for developing BACE1 inhibitors against CAA are discussed. Brain impermeable compounds are considered preferable as they might exhibit sufficient anti-CAA efficacy without causing significant neuronal/synaptic side effects. Early pharmacological intervention to the pathogenesis of CAA is expected to provide significant protection for cerebral vascular health and hence brain health. Brain impermeable BACE1 inhibitors should be optimized and tested as potential anti-CAA therapeutics.

Capillary CAA and perivascular Aβ-deposition: two distinct features of Alzheimer's disease pathology.

PubMed

Attems, Johannes; Yamaguchi, Haruyasu; Saido, Takaomi C; Thal, Dietmar Rudolf

2010-12-15

Cerebral amyloid angiopathy (CAA) is frequently seen in Alzheimer's disease (AD) cases and represents one of its histopathological hallmarks. CAA is characterized by amyloid β-protein (Aβ) deposits within vessel walls. In addition to arteries and veins capillaries can also be affected. Aβ deposition into the capillary wall is, thereby, known as capillary CAA (capCAA) and strongly associated with the apolipoprotein E APOEε4 allele as a risk factor. Aβ deposits along the pericapillary glia limitans are described as pericapillary Aβ (pericapAβ: synonymous with pericapillary CAA in other studies). Here, we studied the relationship between pericapAβ and capCAA in 58 human autopsy cases. Although pericapAβ and capCAA were more frequently found in AD cases compared to controls and although they exhibited a correlation to one another, detailed analysis revealed that there is a significant number of cases with pericapAβ lacking capCAA and vice versa. Moreover, single capillaries show either both pathologies or pericapAβ or capCAA only. There was no local association between these pathologies when analyzing multiple capillaries in each given case. Moreover, pericapAβ predominantly exhibited Aβ(42) whereas capCAA contained both Aβ(42) and Aβ(40). These differences as well as differences in the related astroglial reaction indicate that pericapAβ and capCAA are not directly linked. PericapAβ appears to represent initial Aβ accumulation along the glia limitans that is involved in the perivascular drainage of apoE and Aβ regardless of the APOE genotype whereas capCAA could be explained by a limited transendothelial clearance of apoE4-Aβ complexes compared to apoE2/3-Aβ complexes. Copyright © 2010 Elsevier B.V. All rights reserved.

NASA Principal Center for Review of Clean Air Act Regulations

NASA Technical Reports Server (NTRS)

Clark-Ingram, Marceia; Munafo, Paul M. (Technical Monitor)

2002-01-01

The Clean Air Act (CAA) regulations have greatly impacted materials and processes utilized in the manufacture of aerospace hardware. Code JE/ NASA's Environmental Management Division at NASA Headquarters recognized the need for a formal, Agency-wide review process of CAA regulations. Marshall Space Flight Center (MSFC) was selected as the 'Principal Center for Review of Clean Air Act Regulations'. This presentation describes the centralized support provided by MSFC for the management and leadership of NASA's CAA regulation review process.

75 FR 75463 - Clean Air Act Operating Permit Program; Petition To Object to Title V Permit for Luke Paper...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-03

... ENVIROMENTAL PROTECTION AGENCY [FRL-9234-9] Clean Air Act Operating Permit Program; Petition To Object to Title V Permit for Luke Paper Company, Luke, MD AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of final action. SUMMARY: Pursuant to section 505(b)(2) of the Clean Air Act (CAA), the...

NASA's Principal Center for Review of Clean Air Act Regulations

NASA Technical Reports Server (NTRS)

Clark-Ingram, Marceia

2003-01-01

Marshall Space Flight Center (MSFC) was selected as the Principal Center for review of Clean Air Act (CAA) regulations. The CAA Principal Center is tasked to: 1) Provide centralized support to NASA/HDQ Code JE for the management and leadership of NASA's CAA regulation review process; 2) Identify potential impact from proposed CAA regulations to NASA program hardware and supporting facilities. The Shuttle Environmental Assurance Initiative, one of the responsibilities of the NASA CAA Working Group (WG), is described in part of this viewgraph presentation.

MetaCAA: A clustering-aided methodology for efficient assembly of metagenomic datasets.

PubMed

Reddy, Rachamalla Maheedhar; Mohammed, Monzoorul Haque; Mande, Sharmila S

2014-01-01

A key challenge in analyzing metagenomics data pertains to assembly of sequenced DNA fragments (i.e. reads) originating from various microbes in a given environmental sample. Several existing methodologies can assemble reads originating from a single genome. However, these methodologies cannot be applied for efficient assembly of metagenomic sequence datasets. In this study, we present MetaCAA - a clustering-aided methodology which helps in improving the quality of metagenomic sequence assembly. MetaCAA initially groups sequences constituting a given metagenome into smaller clusters. Subsequently, sequences in each cluster are independently assembled using CAP3, an existing single genome assembly program. Contigs formed in each of the clusters along with the unassembled reads are then subjected to another round of assembly for generating the final set of contigs. Validation using simulated and real-world metagenomic datasets indicates that MetaCAA aids in improving the overall quality of assembly. A software implementation of MetaCAA is available at https://metagenomics.atc.tcs.com/MetaCAA. Copyright © 2014 Elsevier Inc. All rights reserved.

Cellular antioxidant activity (CAA) assay for assessing antioxidants, foods, and dietary supplements.

PubMed

Wolfe, Kelly L; Liu, Rui Hai

2007-10-31

A cellular antioxidant activity (CAA) assay for quantifying the antioxidant activity of phytochemicals, food extracts, and dietary supplements has been developed. Dichlorofluorescin is a probe that is trapped within cells and is easily oxidized to fluorescent dichlorofluorescein (DCF). The method measures the ability of compounds to prevent the formation of DCF by 2,2'-azobis(2-amidinopropane) dihydrochloride (ABAP)-generated peroxyl radicals in human hepatocarcinoma HepG2 cells. The decrease in cellular fluorescence when compared to the control cells indicates the antioxidant capacity of the compounds. The antioxidant activities of selected phytochemicals and fruit extracts were evaluated using the CAA assay, and the results were expressed in micromoles of quercetin equivalents per 100 micromol of phytochemical or micromoles of quercetin equivalents per 100 g of fresh fruit. Quercetin had the highest CAA value, followed by kaempferol, epigallocatechin gallate (EGCG), myricetin, and luteolin among the pure compounds tested. Among the selected fruits tested, blueberry had the highest CAA value, followed by cranberry > apple = red grape > green grape. The CAA assay is a more biologically relevant method than the popular chemistry antioxidant activity assays because it accounts for some aspects of uptake, metabolism, and location of antioxidant compounds within cells.

Early Warning Report: Use of Contractors to Conduct Clean Air Act Risk Management Program Inspections in Certain States Goes Against Court Decisions

EPA Pesticide Factsheets

Report #12-P-0376, March 28, 2012. The OIG is currently evaluating whether the EPA has adequate management controls for ensuring the effectiveness of its Clean Air Act (CAA) Section 112(r) risk management program inspections.

ACHP | Recovery Act Section 106 Training

Science.gov Websites

Working with Section 106 Federal, State, & Tribal Programs Training & Education Publications Search skip specific nav links Home arrow Training and Education arrow Recovery Act Section 106 Training RECOVERY ACT SECTION 106 TRAINING 2009 Recovery Act Section 106 Seminar Schedule Registration Forms General

Intramolecular triple helix as a model for regular polyribonucleotide (CAA)(n).

PubMed

Efimov, Alexander V; Spirin, Alexander S

2009-10-09

The regular (CAA)(n) polyribonucleotide, as well as the omega leader sequence containing (CAA)-rich core, have recently been shown to form cooperatively melted and compact structures. In this report, we propose a structural model for the (CAA)(n) sequence in which the polyribonucleotide chain is folded upon itself, so that it forms an intramolecular triple helix. The triple helix is stabilized by hydrogen bonding between bases thus forming coplanar triads, and by stacking interactions between the base triads. A distinctive feature of the proposed triple helix is that it does not contain the canonical double-helix elements. The difference from the known triple helices is that Watson-Crick hydrogen bond pairings do not take place in the interactions between the bases within the base triads.

The CAA repeat polymorphism in the ZFHX3 gene is associated with risk of coronary heart disease in a Chinese population.

PubMed

Sun, Shunchang; Zhang, Wenwu; Chen, Xi; Song, Huiwen

2015-04-01

Coronary heart disease (CHD) is a disease resulting from the interaction between genetic variations and environmental factors. Zinc finger homeobox 3 (ZFHX3) is a transcription factor and contains a poly-glutamine tract in a compositionally biased region that is encoded by exon 9, containing a cluster of CAG and CAA triplets followed by the polymorphic CAA repeats: (CAG)2(CAA)2(CAG)3CAACAG(CAA)nGCA. Thus, nine successive glutamine residues precede the poly-glutamine tract, encoded by the polymorphic CAA repeats. The aim of this study was to investigate the association of the CAA repeat polymorphism in exon 9 of the ZFHX3 gene with the risk of CHD in a Chinese population. The CAA repeat polymorphism was determined by polymerase chain reaction followed by DNA sequencing in 321 CHD patients. Genotype frequencies were compared using the non-parametric mood median test. Four alleles of CAG(CAA)10GCA, CAG(CAA)8GCA, CAG(CAA)9GCA, and CAG(CAA)11GCA were found in Chinese CHD patients in exon 9 of the ZFHX3 gene. The CAG(CAA)10GCA was a major allele (95.95%), and the CAG(CAA)8GCA was a minor allele (3.58%). The CAG(CAA)9GCA and CAG(CAA)11GCA were rare alleles (0.31% and 0.16%). The CAG(CAA)10GCA allele encodes a poly-glutamine tract of 19 residues. Importantly, the CHD patients homozygous for the CAG(CAA)10GCA allele had a higher risk of CHD, compared to the heterozygous patients carrying a CAG(CAA)8GCA allele. Moreover, the CAG(CAA)10GCA allele was significantly associated with hypertension, diabetes mellitus, or dyslipidemia (P < 0.05). Thus, the CAA repeat polymorphism in exon 9 of the ZFHX3 gene contributes to the CHD susceptibility in the Chinese population.

Using Focus Groups to Investigate the Presence of Formative Feedback in CAA

ERIC Educational Resources Information Center

Broughton, Stephen; Hernandez-Martinez, Paul; Robinson, Carol L.

2012-01-01

The aim of this project was to examine the effectiveness of feedback offered by computer-aided assessment (CAA). CAA provides practice tests for undergraduates, and feedback to help them improve their scores and mathematical understanding. However, there is a lack of evidence-based literature on the effect of formative feedback in mathematics…

Spinocerebellar ataxia 17: full phenotype in a 41 CAG/CAA repeats carrier.

PubMed

Origone, Paola; Gotta, Fabio; Lamp, Merit; Trevisan, Lucia; Geroldi, Alessandro; Massucco, Davide; Grazzini, Matteo; Massa, Federico; Ticconi, Flavia; Bauckneht, Matteo; Marchese, Roberta; Abbruzzese, Giovanni; Bellone, Emilia; Mandich, Paola

2018-01-01

Spinocerebellar ataxia 17 (SCA17) is one of the most heterogeneous forms of autosomal dominant cerebellar ataxias with a large clinical spectrum which can mimic other movement disorders such as Huntington disease (HD), dystonia and parkinsonism. SCA17 is caused by an expansion of CAG/CAA repeat in the Tata binding protein ( TBP ) gene. Normal alleles contain 25 to 40 CAG/CAA repeats, alleles with 50 or greater CAG/CAA repeats are pathological with full penetrance. Alleles with 43 to 49 CAG/CAA repeats were also reported and their penetrance is estimated between 50 and 80%. Recently few symptomatic individuals having 41 and 42 repeats were reported but it is still unclear whether CAG/CAA repeats of 41 or 42 are low penetrance disease-causing alleles. Thus, phenotypic variability like the disease course in subject with SCA17 locus restricted expansions remains to be fully understood. The patients was a 63-year-old woman who, at 54 years, showed personality changes and increased frequency of falls. At 55 years of age neuropsychological tests showed executive attention and visuospatial deficit. At the age of 59 the patient developed dysarthria and a progressive cognitive deficit. The neurological examination showed moderate gait ataxia, dysdiadochokinesia and dysmetria, dysphagia, dysarthria and abnormal saccadic pursuit, severe axial asynergy during postural changes, choreiform dyskinesias. Molecular analysis of the TBP gene demonstrated an allele with 41 repeat suggesting that 41 CAG/CCG TBP repeats could be an allele associated with the full clinical spectrum of SCA17. The described case with the other similar cases described in the literature suggests that 41 CAG/CAA trinucleotides should be considered as critical threshold in SCA17. We suggest that SCA17 diagnosis should be suspected in patients presenting with movement disorders associated with other neurodegenerative signs and symptoms.

Hybrid CFD/CAA Modeling for Liftoff Acoustic Predictions

NASA Technical Reports Server (NTRS)

Strutzenberg, Louise L.; Liever, Peter A.

2011-01-01

This paper presents development efforts at the NASA Marshall Space flight Center to establish a hybrid Computational Fluid Dynamics and Computational Aero-Acoustics (CFD/CAA) simulation system for launch vehicle liftoff acoustics environment analysis. Acoustic prediction engineering tools based on empirical jet acoustic strength and directivity models or scaled historical measurements are of limited value in efforts to proactively design and optimize launch vehicles and launch facility configurations for liftoff acoustics. CFD based modeling approaches are now able to capture the important details of vehicle specific plume flow environment, identifY the noise generation sources, and allow assessment of the influence of launch pad geometric details and sound mitigation measures such as water injection. However, CFD methodologies are numerically too dissipative to accurately capture the propagation of the acoustic waves in the large CFD models. The hybrid CFD/CAA approach combines the high-fidelity CFD analysis capable of identifYing the acoustic sources with a fast and efficient Boundary Element Method (BEM) that accurately propagates the acoustic field from the source locations. The BEM approach was chosen for its ability to properly account for reflections and scattering of acoustic waves from launch pad structures. The paper will present an overview of the technology components of the CFD/CAA framework and discuss plans for demonstration and validation against test data.

40 CFR 51.902 - Which classification and nonattainment area planning provisions of the CAA shall apply to areas...

Code of Federal Regulations, 2011 CFR

2011-07-01

... area planning provisions of the CAA shall apply to areas designated nonattainment for the 8-hour NAAQS? 51.902 Section 51.902 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Implementation of 8-hour Ozone National Ambient Air Quality Standard § 51.902 Which classification and...

40 CFR 51.902 - Which classification and nonattainment area planning provisions of the CAA shall apply to areas...

Code of Federal Regulations, 2014 CFR

2014-07-01

... area planning provisions of the CAA shall apply to areas designated nonattainment for the 1997 8-hour NAAQS? 51.902 Section 51.902 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Implementation of 8-hour Ozone National Ambient Air Quality Standard § 51.902 Which classification and...

40 CFR 51.902 - Which classification and nonattainment area planning provisions of the CAA shall apply to areas...

Code of Federal Regulations, 2012 CFR

2012-07-01

... area planning provisions of the CAA shall apply to areas designated nonattainment for the 1997 8-hour NAAQS? 51.902 Section 51.902 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Implementation of 8-hour Ozone National Ambient Air Quality Standard § 51.902 Which classification and...

40 CFR 51.902 - Which classification and nonattainment area planning provisions of the CAA shall apply to areas...

Code of Federal Regulations, 2013 CFR

2013-07-01

... area planning provisions of the CAA shall apply to areas designated nonattainment for the 1997 8-hour NAAQS? 51.902 Section 51.902 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Implementation of 8-hour Ozone National Ambient Air Quality Standard § 51.902 Which classification and...

40 CFR 51.902 - Which classification and nonattainment area planning provisions of the CAA shall apply to areas...

Code of Federal Regulations, 2010 CFR

2010-07-01

... area planning provisions of the CAA shall apply to areas designated nonattainment for the 8-hour NAAQS? 51.902 Section 51.902 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Implementation of 8-hour Ozone National Ambient Air Quality Standard § 51.902 Which classification and...

Third Computational Aeroacoustics (CAA) Workshop on Benchmark Problems

NASA Technical Reports Server (NTRS)

Dahl, Milo D. (Editor)

2000-01-01

The proceedings of the Third Computational Aeroacoustics (CAA) Workshop on Benchmark Problems cosponsored by the Ohio Aerospace Institute and the NASA Glenn Research Center are the subject of this report. Fan noise was the chosen theme for this workshop with representative problems encompassing four of the six benchmark problem categories. The other two categories were related to jet noise and cavity noise. For the first time in this series of workshops, the computational results for the cavity noise problem were compared to experimental data. All the other problems had exact solutions, which are included in this report. The Workshop included a panel discussion by representatives of industry. The participants gave their views on the status of applying computational aeroacoustics to solve practical industry related problems and what issues need to be addressed to make CAA a robust design tool.

[Effects of the adsorbent CAA for hemopurification on normal components of human plasma in removing methylene blue].

PubMed

Ma, Yu; Xia, Yun; Yang, Xiaolan; Yu, Ming'an

2003-06-01

Virus inactivation of plasma can be achieved by phototreatment with methylene blue (MB). Subsequently, elimination of MB may reduce the adverse effects of MB. This study examined the effects of adsorbing MB with the use of cross-linked agar bead entrapped attapulgite clay (CAA) on normal ingredients in MB-treated plasma units. The biomedical characteristics of CAA were assessed by determination of partial biochemical indexes, coagulation potency and some cationic concentration in a control sample and the MB-treated plasma eluted from CAA column. The biochemistry indexes or K+, Na+ in plasma were almost unaltered before and after CAA adsorption. In contrast, the concentrations of CA2+ and Mg2+ increased and the blood ammonium decreased obviously. The activated partial thromboplastin time (APTT) was prolonged from 42 s to 53 s, and prothrombin time (PT) from 13 s to 14 s. The result indicates that CAA as an adsorbent for hemopurification retains the most important characters of human plasma. CAA can be useful for the elimination of MB in MB-treated plasma and does not bring on harmful alteration in clinical significance.

78 FR 63887 - Approval and Promulgation of Implementation Plans; Approval and Promulgation of State Air Quality...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-25

..., revisions to the State of Iowa's State Implementation Plan (SIP), Title V program, and Clean Air Act (CAA..., subject to the requirements of sections 111(d) and 129 of the CAA, do not exist in the State; and... changes to the Title V program, pursuant to section 500 of the CAA. DATES: This rule is effective December...

CFD-CAA Coupled Calculations of a Tandem Cylinder Configuration to Assess Facility Installation Effects

NASA Technical Reports Server (NTRS)

Redonnet, Stephane; Lockard, David P.; Khorrami, Mehdi R.; Choudhari, Meelan M.

2011-01-01

This paper presents a numerical assessment of acoustic installation effects in the tandem cylinder (TC) experiments conducted in the NASA Langley Quiet Flow Facility (QFF), an open-jet, anechoic wind tunnel. Calculations that couple the Computational Fluid Dynamics (CFD) and Computational Aeroacoustics (CAA) of the TC configuration within the QFF are conducted using the CFD simulation results previously obtained at NASA LaRC. The coupled simulations enable the assessment of installation effects associated with several specific features in the QFF facility that may have impacted the measured acoustic signature during the experiment. The CFD-CAA coupling is based on CFD data along a suitably chosen surface, and employs a technique that was recently improved to account for installed configurations involving acoustic backscatter into the CFD domain. First, a CFD-CAA calculation is conducted for an isolated TC configuration to assess the coupling approach, as well as to generate a reference solution for subsequent assessments of QFF installation effects. Direct comparisons between the CFD-CAA calculations associated with the various installed configurations allow the assessment of the effects of each component (nozzle, collector, etc.) or feature (confined vs. free jet flow, etc.) characterizing the NASA LaRC QFF facility.

MTU America Inc. Clean Air Act Settlement

EPA Pesticide Factsheets

The settlement resolves an enforcement action by EPA and the U.S. Department of Justice against MTU for Clean Air Act (CAA) violations involving MTU’s failure to comply with certain testing, certification and reporting.

Clinical Characterization of Canine Acanthomatous Ameloblastoma (CAA) in 263 dogs and the Influence of Postsurgical Histopathological Margin on Local Recurrence.

PubMed

Goldschmidt, Stephanie L; Bell, Cindy M; Hetzel, Scott; Soukup, Jason

2017-12-01

Canine acanthomatous ameloblastoma (CAA) has been reported to be the most common odontogenic tumor in dogs. This retrospective study evaluated 263 dogs with histopathologically confirmed CAA. Within this data set, CAA presents most commonly in the rostral mandible in adult large breed dogs, with golden retriever dogs being overrepresented. Patients with appropriate follow-up after curative intent surgery were evaluated to assess the effect of histopathological margin on local tumor recurrence. No local recurrence was noted in any patient. This study raises questions about what the recommended surgical margin should be for treatment of CAA. It also serves as a stimulus for discussion as to whether further treatment for CAA is required when inadequate surgical margins are obtained, or if medical surveillance would be an appropriate management recommendation. Prospective studies are necessary to answer these questions.

Association of CAA and TATC Insertion/Deletion Genetic Polymorphisms in RTN4 3'-UTR with Hepatocellular Carcinoma Risk.

PubMed

Wang, NaNa; Chen, KeYu; Xu, Jia; Yuan, Fang; Li, HongYu; Deng, FengMei; Zhang, LuShun

2018-01-01

Evidence from recent researchers suggested that RTN4 is a multifunctional gene, including tumor suppression, apoptosis, vascular remodeling, and inhibition of axonal regeneration. The CAA and TATC insertion/deletion polymorphisms (CAA/TATC polymorphisms) of RTN4 3″-untranslated regions (UTRs) have been linked to cervical squamous cell carcinoma (CSCC), uterine leiomyomas (UL) and non-small cell lung cancer (NSCLC). However, the association between these two polymorphisms sites with Hepatocellular Carcinoma (HCC) risk was not carry out before. A total of 284 HCC patients and 484 control subjects were recruited for this study. The RTN4 CAA/TATC insertion/deletion genotypes were determined using polymerase chain reaction (PCR) assay. The ID/DD genotypes of CAA were significantly associated with an increased risk of HCC compared with the II genotype (ID vs. II: OR = 1.50, 95% CI: 1.10-2.04; DD vs. II: OR = 2.00, 95%CI: 1.15-3.46). Meanwhile, the frequency of D allele of CAA was significantly related with an increased risk of HCC compared with the I allele (D vs. I: OR = 1.39, 95% CI: 1.12-1.73). The ID genotypes of TATC was significantly associated with an increased risk of HCC compared with the DD genotype (ID vs. DD: OR = 1.70, 95% CI: 1.23-2.33). The present study provided evidence that RTN4 CAA/TATC polymorphisms were associated with HCC development in Chinese Han population.

Instability of expanded CAG/CAA repeats in spinocerebellar ataxia type 17.

PubMed

Gao, Rui; Matsuura, Tohru; Coolbaugh, Mary; Zühlke, Christine; Nakamura, Koichiro; Rasmussen, Astrid; Siciliano, Michael J; Ashizawa, Tetsuo; Lin, Xi

2008-02-01

Trinucleotide repeat expansions are dynamic mutations causing many neurological disorders, and their instability is influenced by multiple factors. Repeat configuration seems particularly important, and pure repeats are thought to be more unstable than interrupted repeats. But direct evidence is still lacking. Here, we presented strong support for this hypothesis from our studies on spinocerebellar ataxia type 17 (SCA17). SCA17 is a typical polyglutamine disease caused by CAG repeat expansion in TBP (TATA binding protein), and is unique in that the pure expanded polyglutamine tract is coded by either a simple configuration with long stretches of pure CAGs or a complex configuration containing CAA interruptions. By small pool PCR (SP-PCR) analysis of blood DNA from SCA17 patients of distinct racial backgrounds, we quantitatively assessed the instability of these two types of expanded alleles coding similar length of polyglutamine expansion. Mutation frequency in patients harboring pure CAG repeats is 2-3 folds of those with CAA interruptions. Interestingly, the pure CAG repeats showed both expansion and deletion while the interrupted repeats exhibited mostly deletion at a significantly lower frequency. These data strongly suggest that repeat configuration is a critical determinant for instability, and CAA interruptions might serve as a limiting element for further expansion of CAG repeats in SCA17 locus, suggesting a molecular basis for lack of anticipation in SCA17 families with interrupted CAG expansion.

Cluster Ion Spectrometry (CIS) Data Archiving in the CAA

NASA Astrophysics Data System (ADS)

Dandouras, I. S.; Barthe, A.; Penou, E.; Brunato, S.; Reme, H.; Kistler, L. M.; Blagau, A.; Facsko, G.; Kronberg, E.; Laakso, H. E.

2009-12-01

The Cluster Active Archive (CAA) aims at preserving the four Cluster spacecraft data, so that they are usable in the long-term by the scientific community as well as by the instrument team PIs and Co-Is. This implies that the data are filed together with the descriptive and documentary elements making it possible to select and interpret them. The CIS (Cluster Ion Spectrometry) experiment is a comprehensive ionic plasma spectrometry package onboard the four Cluster spacecraft, capable of obtaining full three-dimensional ion distributions (about 0 to 40 keV/e) with a time resolution of one spacecraft spin (4 sec) and with mass-per-charge composition determination. The CIS package consists of two different instruments, a Hot Ion Analyser (HIA) and a time-of-flight ion Composition Distribution Function (CODIF) analyser. For the archival of the CIS data a multi-level approach has been adopted. The CAA archival includes processed raw data (Level 1 data), moments of the ion distribution functions (Level 2 data), and calibrated high-resolution data in a variety of physical units (Level 3 data). The latter are 3-D ion distribution functions and 2-D pitch-angle distributions. In addition, a software package has been developed to allow the CAA user to interactively calculate partial or total moments of the ion distributions. Instrument cross-calibration has been an important activity in preparing the data for archival. The CIS data archive includes also experiment documentation, graphical products for browsing through the data, and data caveats. In addition, data quality indexes are under preparation, to help the user. Given the complexity of an ion spectrometer, and the variety of its operational modes, each one being optimised for a different magnetospheric region or measurement objective, consultation of the data caveats by the end user will always be a necessary step in the data analysis.

76 FR 26768 - Notice of Lodging of a Consent Decree Under The Clean Water Act, The Clean Air Act, and The...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-09

... BP Exploration (Alaska) Inc. (``BPXA'')'s operation of oil pipelines on the North Slope of Alaska... Consent Decree in United States v. BP Exploration (Alaska) Inc., Civil Action No. 3:09-CV-00064-JWS was..., 1321, as amended by the Oil Pollution Act of 1990, 33 U.S.C. 2701 et seq.; the Clean Air Act (CAA), 42...

Safe Drinking Water Act (SDWA) Resources and FAQs ...

EPA Pesticide Factsheets

ECHO, Enforcement and Compliance History Online, provides compliance and enforcement information for approximately 800,000 EPA-regulated facilities nationwide. ECHO includes permit, inspection, violation, enforcement action, and penalty information about facilities regulated under the Clean Air Act (CAA) Stationary Source Program, Clean Water Act (CWA) National Pollutant Elimination Discharge System (NPDES), and/or Resource Conservation and Recovery Act (RCRA). Information also is provided on surrounding demographics when available.

Structure at 1.3 A resolution of Rhodothermus marinus caa(3) cytochrome c domain.

PubMed

Srinivasan, Vasundara; Rajendran, Chitra; Sousa, Filipa L; Melo, Ana M P; Saraiva, Lígia M; Pereira, Manuela M; Santana, Margarida; Teixeira, Miguel; Michel, Hartmut

2005-02-04

The cytochrome c domain of subunit II from the Rhodothermus marinus caa(3) HiPIP:oxygen oxidoreductase, a member of the superfamily of heme-copper-containing terminal oxidases, was produced in Escherichia coli and characterised. The recombinant protein, which shows the same optical absorption and redox properties as the corresponding domain in the holo enzyme, was crystallized and its structure was determined to a resolution of 1.3 A by the multiwavelength anomalous dispersion (MAD) technique using the anomalous dispersion of the heme iron atom. The model was refined to final R(cryst) and R(free) values of 13.9% and 16.7%, respectively. The structure reveals the insertion of two short antiparallel beta-strands forming a small beta-sheet, an interesting variation of the classical all alpha-helical cytochrome c fold. This modification appears to be common to all known caa(3)-type terminal oxidases, as judged by comparative modelling and by analyses of the available amino acid sequences for these enzymes. This is the first high-resolution crystal structure reported for a cytochrome c domain of a caa(3)-type terminal oxidase. The R.marinus caa(3) uses HiPIP as the redox partner. The calculation of the electrostatic potential at the molecular surface of this extra C-terminal domain provides insights into the binding to its redox partner on one side and its interaction with the remaining subunit II on the other side.

CAA for Jet Noise Physics

NASA Technical Reports Server (NTRS)

Mankbadi, Reda

2001-01-01

Dr. Mankbadi summarized recent CAA results. Examples of the effect of various boundary condition schemes on the computed acoustic field, for a point source in a uniform flow, were shown. Solutions showing the impact of inflow excitations on the result were also shown. Results from a large eddy simulation, using a fourth-order MacCormack scheme with a Smagorinsky sub-grid turbulence model, were shown for a Mach 2.1 unheated jet. The results showed that the results were free from spurious modes. Results were shown for a Mach 1.4 jet using LES in the near field and the Kirchhoff method for the far field. Predicted flow field characteristics were shown to be in good agreement with data and predicted far field directivities were shown to be in qualitative agree with experimental measurements.

Human Factors Assessment of the UH-60M Common Avionics Architecture System (CAAS) Crew Station During the Limited User Evaluation (LEUE)

DTIC Science & Technology

2005-12-01

weapon system evaluation as a high-level architecture and distributed interactive simulation 6 compliant, human-in-the-loop, virtual environment...Directorate to participate in the Limited Early User Evaluation (LEUE) of the Common Avionics Architecture System (CAAS) cockpit. ARL conducted a human...CAAS, the UH-60M PO conducted a limited early user evaluation (LEUE) to evaluate the integration of the CAAS in the UH-60M crew station. The

76 FR 20853 - Approval and Promulgation of Air Quality Implementation Plans; Kentucky; Approval of Section 110...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-14

... NAAQS through the year 2020 for the Four Kentucky Areas. These maintenance plans meet applicable... period of 10 years after redesignation, consistent with the CAA section 175A(a). EPA approved Kentucky's... attainment areas) were required to submit 10-year maintenance plans pursuant to section 110(a)(1) of the CAA...

Utilizing the ultrasensitive Schistosoma up-converting phosphor lateral flow circulating anodic antigen (UCP-LF CAA) assay for sample pooling-strategies.

PubMed

Corstjens, Paul L A M; Hoekstra, Pytsje T; de Dood, Claudia J; van Dam, Govert J

2017-11-01

Methodological applications of the high sensitivity genus-specific Schistosoma CAA strip test, allowing detection of single worm active infections (ultimate sensitivity), are discussed for efficient utilization in sample pooling strategies. Besides relevant cost reduction, pooling of samples rather than individual testing can provide valuable data for large scale mapping, surveillance, and monitoring. The laboratory-based CAA strip test utilizes luminescent quantitative up-converting phosphor (UCP) reporter particles and a rapid user-friendly lateral flow (LF) assay format. The test includes a sample preparation step that permits virtually unlimited sample concentration with urine, reaching ultimate sensitivity (single worm detection) at 100% specificity. This facilitates testing large urine pools from many individuals with minimal loss of sensitivity and specificity. The test determines the average CAA level of the individuals in the pool thus indicating overall worm burden and prevalence. When requiring test results at the individual level, smaller pools need to be analysed with the pool-size based on expected prevalence or when unknown, on the average CAA level of a larger group; CAA negative pools do not require individual test results and thus reduce the number of tests. Straightforward pooling strategies indicate that at sub-population level the CAA strip test is an efficient assay for general mapping, identification of hotspots, determination of stratified infection levels, and accurate monitoring of mass drug administrations (MDA). At the individual level, the number of tests can be reduced i.e. in low endemic settings as the pool size can be increased as opposed to prevalence decrease. At the sub-population level, average CAA concentrations determined in urine pools can be an appropriate measure indicating worm burden. Pooling strategies allowing this type of large scale testing are feasible with the various CAA strip test formats and do not affect

Structure of caa(3) cytochrome c oxidase--a nature-made enzyme-substrate complex.

PubMed

Noor, Mohamed Radzi; Soulimane, Tewfik

2013-05-01

Aerobic respiration, the energetically most favorable metabolic reaction, depends on the action of terminal oxidases that include cytochrome c oxidases. The latter forms a part of the heme-copper oxidase superfamily and consists of three different families (A, B, and C types). The crystal structures of all families have now been determined, allowing a detailed structural comparison from evolutionary and functional perspectives. The A2-type oxidase, exemplified by the Thermus thermophilus caa(3) oxidase, contains the substrate cytochrome c covalently bound to the enzyme complex. In this article, we highlight the various features of caa(3) enzyme and provide a discussion of their importance, including the variations in the proton and electron transfer pathways.

Modification of the cellular antioxidant activity (CAA) assay to study phenolic antioxidants in a Caco-2 cell line.

PubMed

Kellett, Mary E; Greenspan, Phillip; Pegg, Ronald B

2018-04-01

In vitro assays are widely used to analyze the antioxidant potential of compounds, but they cannot accurately predict antioxidant behavior in living systems. Cell-based assays, like the cellular antioxidant activity (CAA) assay, are gaining importance as they provide a biological perspective. When the CAA assay was employed to study phenolic antioxidants using hepatocarcinoma (HepG2) cells, quercetin showed antioxidant activity in HepG2 cells; 25 and 250μM quercetin reduced fluorescence by 17.1±0.9% and 58.6±2.4%, respectively. (+)-Catechin, a phenolic antioxidant present in many foods, bestowed virtually no CAA in HepG2 cells. When Caco-2 cells were employed, more robust antioxidant activity was observed; 50μM (+)-catechin and quercetin reduced fluorescence by 54.1±1.4% and 63.6±0.9%, respectively. Based on these results, likely due to differences in active membrane transport between the cell types, the Caco-2-based CAA assay appears to be a more appropriate method for the study of certain dietary phenolics. Copyright © 2017 Elsevier Ltd. All rights reserved.

Cardiolipin deficiency causes a dissociation of the b 6 c:caa 3 megacomplex in B. subtilis membranes.

PubMed

García Montes de Oca, Led Yered Jafet; Cabellos Avelar, Tecilli; Picón Garrido, Gerardo Ignacio; Chagoya-López, Alicia; González de la Vara, Luis; Delgado Buenrostro, Norma Laura; Chirino-López, Yolanda Irasema; Gómez-Lojero, Carlos; Gutiérrez-Cirlos, Emma Berta

2016-08-01

The associations among respiratory complexes in energy-transducing membranes have been established. In fact, it is known that the Gram-negative bacteria Paracoccus denitrificans and Escherichia coli have respiratory supercomplexes in their membranes. These supercomplexes are important for channeling substrates between enzymes in a metabolic pathway, and the assembly of these supercomplexes depends on the protein subunits and membrane lipids, mainly cardiolipin, which is present in both the mitochondrial inner membrane and bacterial membranes. The Gram-positive bacterium Bacillus subtilis has a branched respiratory chain, in which some complexes generate proton motive force whereas others constitute an escape valve of excess reducing power. Some peculiarities of this respiratory chain are the following: a type II NADH dehydrogenase, a unique b 6 c complex that has a b 6 type cytochrome with a covalently bound heme, and a c-type heme attached to the third subunit, which is similar to subunit IV of the photosynthetic b 6 f complex. Cytochrome c oxygen reductase (caa 3 ) contains a c-type cytochrome on subunit I. We previously showed that the b 6 c and the caa 3 complexes form a supercomplex. Both the b 6 c and the caa 3 together with the quinol oxygen reductase aa 3 generate the proton motive force in B. subtilis. In order to seek proof that this supercomplex is important for bacterial growth in aerobic conditions we compared the b 6 c: caa 3 supercomplex from wild type membranes with membranes from two mutants lacking cardiolipin. Both mutant complexes were found to have similar activity and heme content as the wild type. Clear native electrophoresis showed that mutants lacking cardiolipin had b 6 c:caa 3 supercomplexes of lower mass or even individual complexes after membrane solubilization with digitonin. The use of dodecyl maltoside revealed a more evident difference between wild-type and mutant supercomplexes. Here we provide evidence showing that cardiolipin

Effect of consecutive alternating administration (CAA) of a triple anti-enteroviral combination on Coxsackievirus B1 neuroinfection in mice.

PubMed

Stoyanova, Adelina; Nikolova, Ivanka; Galabov, Angel S

2015-09-01

Currently, clinically effective antivirals for use in the treatment of enteroviral (EV) infections do not exist. The main reason is the development of drug resistance, the principle obstacle in the development of EV infection chemotherapy, based til now on monotherapy. The most important achievement of our previous studies was the development of a novel scheme for in vivo application of a triple combination of EV inhibitors with different modes of action against Coxsackievirus B (CVB) infections in mice. It consists of consecutive alternating administration (CAA) of the substances in the combination. Here, we tested the effect of the triple combination pleconaril, guanidine-HCl, and oxoglaucine (PGO) via CAA in newborn mice infected with a neurotropic strain of CVB1 (20 LD50 per mouse). This combination manifested a considerable protective effect with pleconaril doses of 25-200mg/kg: it decreased mortality rate (protection index, PI, between 31.3% and 67.7%) and increased mean survival time (MST) by 4-6days. Pleconaril monotherapy demonstrated activity similar to that of PGO via CAA, as measured by PI values, but MST values were slightly lower. However, it also greatly suppressed growth of infected suckling mice, especially at 200mg/kg. This toxic effect was avoided with CAA of PGO at pleconaril doses of 25-100mg/kg. Pleconaril monotherapy administered every 3days was ineffective. The PGO with CAA treatment course decreased infectious virus content, whereas pleconaril monotherapy did not. Analysis of drug-sensitivity in brain samples from CVB1 infected mice, based on IC50 (50% inhibitory concentration) values from cell culture experiments, showed that the CAA course counteracted the development of drug resistance to pleconaril and oxoglaucine in the triple PGO combination and increased drug sensitivity. In contrast, pleconaril and oxoglaucine monotherapies resulted in drug resistance. This data clearly proves the effectiveness of the proposed novel approach-the CAA

Aβ-related angiitis: comparison with CAA without inflammation and primary CNS vasculitis.

PubMed

Salvarani, Carlo; Hunder, Gene G; Morris, Jonathan M; Brown, Robert D; Christianson, Teresa; Giannini, Caterina

2013-10-29

To analyze the clinical findings, response to therapy, and outcomes of patients with cerebral vascular amyloid-β (Aβ) deposition with and without inflammatory vascular infiltration. We report 78 consecutive patients with cerebral vascular Aβ deposition examined at Mayo Clinic Rochester over 25 years (1987 through 2011). Specimens reviewed by a neuropathologist showed 40 with vascular Aβ peptide without inflammation (cerebral amyloid angiopathy [CAA]), 28 with granulomatous vasculitis (Aβ-related angiitis or ABRA), and 10 with perivascular CAA-related inflammation. We also matched findings in 118 consecutive patients with primary CNS vasculitis (PCNSV) without Aβ seen over 25 years (1983 through 2007). Compared to the 40 with CAA, the 28 with ABRA were younger at diagnosis (p = 0.05), had less altered cognition (p = 0.02), fewer neurologic deficits (p = 0.02), and fewer intracranial hemorrhages (<0.001), but increased gadolinium leptomeningeal enhancement (p = 0.01) at presentation, and less mortality and disability at last follow-up (p < 0.001). Compared with PCNSV, the 28 patients with ABRA were older at diagnosis (p < 0.001), had a higher frequency of altered cognition (p = 0.05), seizures/spells (p = 0.006), gadolinium leptomeningeal enhancement (p < 0.001), and intracerebral hemorrhage (p = 0.02), lower frequency of hemiparesis (p = 0.01), visual symptoms (p = 0.04), and MRI evidence of cerebral infarction (p = 0.003), but higher CSF protein levels (p = 0.03). Results of treatment and outcomes in ABRA and PCNSV were similar. ABRA appears to represent a distinct subset of PCNSV.

Determination of the specificity of monoclonal antibodies against Schistosoma mansoni CAA glycoprotein antigen using neoglycoconjugate variants.

PubMed

Carvalho de Souza, Adriana; van Remoortere, Alexandra; Hokke, Cornelis H; Deelder, André M; Vliegenthart, Johannes F G; Kamerling, Johannis P

2005-09-01

The immunogenic O-glycan of circulating anodic antigen (CAA) is a high-molecular-mass polysaccharide with the unique -->6)-[beta-D-GlcpA-(1-->3)]-beta-D-GalpNAc-(1--> repeating unit. To obtain information at the molecular level about the specificity of monoclonal antibodies against CAA, the immunoreactivity of two series of bovine serum albumin-coupled synthetic oligosaccharides related to the CAA O-glycan was monitored using ELISA and surface plasmon resonance spectroscopy. The importance of the axial hydroxyl group of beta-D-GalpNAc for antibody binding was investigated using the following series of analogues: beta-D-GlcpA-(1-->3)-beta-D-GlcpNAc-(1-->O); beta-D-GlcpNAc-(1-->6)-[beta-D-GlcpA-(1-->3)]-beta-D-GlcpNAc-(1-->O); and beta-D-GlcpA-(1-->3)-beta-D-GlcpNAc-(1-->6)-[beta-D-GlcpA-(1-->3)]-beta-D-GlcpNAc-(1-->O). In the second series of analogues, beta-D-Glcp6S-(1-->3)-beta-D-GalpNAc-(1-->O), beta-D-GalpNAc-(1-->6)-[beta-D-Glcp6S-(1-->3)]-beta-D-GalpNAc-(1-->O), and beta-D-Glcp6S-(1-->3)-beta-D-Gal-pNAc-(1-->6)-[beta-D-Glcp6S-(1-->3)]-beta-D-GalpNAc-(1-->O), the native beta-D-GlcpA moiety was replaced by beta-D-Glcp6S to evaluate the influence of the nature of the charge on antibody recognition. Comparison of the immunoreactivity of these series with that measured for conjugates containing corresponding synthetic CAA fragments showed that the antibody binding levels can be correlated to the antibody specificity to CAA fragments. For the most reactive antibodies, the structural changes chosen (beta-D-GalpNAc replaced by beta-D-GlcpNAc, and beta-D-GlcpA replaced by beta-D-Glcp6S) completely eradicated the binding.

ACB-PCR measurement of spontaneous and furan-induced H-ras codon 61 CAA to CTA and CAA to AAA mutation in B6C3F1 mouse liver.

PubMed

Banda, Malathi; Recio, Leslie; Parsons, Barbara L

2013-10-01

Furan is a rodent liver carcinogen, but the mode of action for furan hepatocarcinogenicity is unclear. H-ras codon 61 mutations have been detected in spontaneous liver tumors of B6C3F1 mice, and the fraction of liver tumors carrying H-ras codon 61 CAA to AAA mutation increased in furan-treated mice. Allele-specific competitive blocker PCR (ACB-PCR) has been used previously to quantify early, carcinogen-induced increases in tumor-associated mutations. The present pilot study investigated whether furan drives clonal expansion of pre-existing H-ras mutant cells in B6C3F1 mouse liver. H-ras codon 61 CAA to CTA and CAA to AAA mutations were measured in DNA isolated from liver tissue of female mice treated with 0, 1, 2, 4, or 8 mg furan/kg body weight, five days per week for three weeks, using five mice per treatment group. Spontaneous levels of mutation were low, with two of five control mice having an H-ras codon 61 CTA or AAA mutant fraction (MF) greater than 10(-5) . Several furan-treated mice had H-ras codon 61 AAA or CTA MFs greater than those measured in control mice and lower bound estimates of induced MF were calculated. However, no statistically-significant differences were observed between treatment groups. Therefore, while sustained exposure to furan is carcinogenic, at the early stage of carcinogenesis examined in this study (three weeks), there was not a significant expansion of H-ras mutant cells. Copyright © 2013 Wiley Periodicals, Inc.

78 FR 45922 - Information Collection Request Submitted to OMB for Review and Approval; Comment Request; New...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-30

... confidential in accordance with the Freedom of Information Act (FOIA), 40 CFR Parts 2 and 1042, and class... Section 206(a) of the CAA (42 U.S.C. 7521) and 40 CFR Part 1042. Certification reporting is mandatory under Section 206(a) of CAA (42 U.S.C. 7521) and 40 CFR Part 1042, Subpart C. PLT reporting is mandatory...

Notification: Evaluation of Enforcement Decree Compliance for Selected Clean Air Act Sources

EPA Pesticide Factsheets

Project #OPE-FY14-0016, May 22, 2014. The Office of Inspector General (OIG) plans to begin the preliminary research phase of an evaluation of enforcement decree compliance for selected Clean Air Act (CAA) sources.

42 CFR 417.159 - Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act and the Railway Labor Act. 417.159 Section 417.159 Public....159 Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act...

42 CFR 417.159 - Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 3 2011-10-01 2011-10-01 false Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act and the Railway Labor Act. 417.159 Section 417.159 Public....159 Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act...

75 FR 31843 - Identification of Non-Hazardous Secondary Materials That Are Solid Waste

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-04

...On January 2, 2009, the Environmental Protection Agency (EPA or the Agency) issued an Advanced Notice of Proposed Rulemaking (ANPRM) to solicit comment on which non-hazardous secondary materials that are used as fuels or ingredients in combustion units are solid wastes under the Resource Conservation and Recovery Act (RCRA). The meaning of ``solid waste'' as defined under RCRA is of particular importance since it will determine whether a combustion unit is required to meet emissions standards for solid waste incineration units issued under section 129 of the Clean Air Act (CAA) or emissions standards for commercial, industrial, and institutional boilers issued under CAA section 112. CAA section 129 states that the term ``solid waste'' shall have the meaning ``established by the Administrator pursuant to [RCRA].'' EPA is proposing a definition of non-hazardous solid waste that would be used to identify whether non-hazardous secondary materials burned as fuels or used as ingredients in combustion units are solid waste. EPA is also proposing that non-hazardous secondary materials that have been discarded, and are therefore solid wastes, may be rendered products after they have been processed (altered chemically or physically) into a fuel or ingredient product. This proposed rule is necessary to identify units for the purpose of developing certain standards under sections 112 and 129 of the CAA. In addition to this proposed rule, EPA is concurrently proposing air emission requirements under CAA section 112 for industrial, commercial, and institutional boilers and process heaters, as well as air emission requirements under CAA section 129 for commercial and industrial solid waste incineration units.

The cellulose synthase 3 (CesA3) gene of oomycetes: structure, phylogeny and influence on sensitivity to carboxylic acid amide (CAA) fungicides.

PubMed

Blum, Mathias; Gamper, Hannes A; Waldner, Maya; Sierotzki, Helge; Gisi, Ulrich

2012-04-01

Proper disease control is very important to minimize yield losses caused by oomycetes in many crops. Today, oomycete control is partially achieved by breeding for resistance, but mainly by application of single-site mode of action fungicides including the carboxylic acid amides (CAAs). Despite having mostly specific targets, fungicidal activity can differ even in species belonging to the same phylum but the underlying mechanisms are often poorly understood. In an attempt to elucidate the phylogenetic basis and underlying molecular mechanism of sensitivity and tolerance to CAAs, the cellulose synthase 3 (CesA3) gene was isolated and characterized, encoding the target site of this fungicide class. The CesA3 gene was present in all 25 species included in this study representing the orders Albuginales, Leptomitales, Peronosporales, Pythiales, Rhipidiales and Saprolegniales, and based on phylogenetic analyses, enabled good resolution of all the different taxonomic orders. Sensitivity assays using the CAA fungicide mandipropamid (MPD) demonstrated that only species belonging to the Peronosporales were inhibited by the fungicide. Molecular data provided evidence, that the observed difference in sensitivity to CAAs between Peronosporales and CAA tolerant species is most likely caused by an inherent amino acid configuration at position 1109 in CesA3 possibly affecting fungicide binding. The present study not only succeeded in linking CAA sensitivity of various oomycetes to the inherent CesA3 target site configuration, but could also relate it to the broader phylogenetic context. Copyright © 2012 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.

42 CFR 417.159 - Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act...

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 3 2014-10-01 2014-10-01 false Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act and the Railway Labor Act. 417.159 Section 417.159 Public... § 417.159 Relationship of section 1310 of the Public Health Service Act to the National Labor Relations...

42 CFR 417.159 - Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act...

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 3 2012-10-01 2012-10-01 false Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act and the Railway Labor Act. 417.159 Section 417.159 Public... § 417.159 Relationship of section 1310 of the Public Health Service Act to the National Labor Relations...

42 CFR 417.159 - Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act...

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 3 2013-10-01 2013-10-01 false Relationship of section 1310 of the Public Health Service Act to the National Labor Relations Act and the Railway Labor Act. 417.159 Section 417.159 Public... § 417.159 Relationship of section 1310 of the Public Health Service Act to the National Labor Relations...

28 CFR 55.22 - Requirements of section 5 of the Act.

Code of Federal Regulations, 2011 CFR

2011-07-01

... PROVISIONS OF THE VOTING RIGHTS ACT REGARDING LANGUAGE MINORITY GROUPS Preclearance § 55.22 Requirements of section 5 of the Act. For many jurisdictions, changes in voting laws and practices will be necessary in... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Requirements of section 5 of the Act. 55...

28 CFR 55.22 - Requirements of section 5 of the Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROVISIONS OF THE VOTING RIGHTS ACT REGARDING LANGUAGE MINORITY GROUPS Preclearance § 55.22 Requirements of section 5 of the Act. For many jurisdictions, changes in voting laws and practices will be necessary in... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Requirements of section 5 of the Act. 55...

77 FR 38830 - Notice of Lodging of an Amendment to Consent Decree Under the Clean Air Act

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-29

... Act (``CAA'' or ``Act'') at its thirteen portland cement production facilities in the United States... regulations. The proposed Second Amendment affects only three of the thirteen cement plants addressed in the Consent Decree: the Roberta, Alabama; Harleyville, South Carolina; and Atlanta, Georgia cement plants. The...

Cross-talk between Aβ and endothelial SSAO/VAP-1 accelerates vascular damage and Aβ aggregation related to CAA-AD.

PubMed

Solé, Montse; Miñano-Molina, Alfredo J; Unzeta, Mercedes

2015-02-01

An association between semicarbazide-sensitive amine oxidase (SSAO) and cerebral amyloid angiopathy (CAA) related to Alzheimer's disease (AD) has been largely postulated. Increased SSAO activity and expression have been detected in cerebrovascular tissue and plasma of AD patients, colocalizing with cerebrovascular amyloid-beta (Aβ) deposits. As an enzyme, SSAO metabolizes primary amines generating hydrogen peroxide, ammonia, and aldehydes. The ability of these products to generate oxidative stress, to enhance the advanced glycation end-product generation, to promote the Aβ aggregation in vitro, and to induce apoptosis supports its role in CAA-related vascular pathology. However, whether the SSAO increase constitutes a cause or it is a consequence of the pathologic process has not been elucidated so far. To set up the nature of this relationship, vascular cell models expressing SSAO were treated with different Aβ forms, simulating the CAA conditions in vitro. It was found that the presence of the vasculotropic Dutch-mutated Aβ1-40 increases (Aβ1-40 D) the SSAO-dependent toxicity, which is accompanied by an increase of SSAO protein availability in endothelial cell membranes. In addition, SSAO enhances Aβ1-40 D and Aβ1-42 deposition on vascular cells by both activity-dependent and -independent mechanisms. Thus, we provide evidences indicating that Aβ itself could be one of the factors inducing SSAO increase in AD, enhancing its toxic effect, and inducing the vascular dysfunction and, in turn, that SSAO stimulates Aβ deposition on the vascular walls, thereby contributing to the CAA-AD progression. Therefore, molecules inhibiting SSAO could provide an alternative treatment for preventing/delaying the progress of CAA-AD-associated vasculopathy. Copyright © 2015 Elsevier Inc. All rights reserved.

28 CFR 5.306 - Exemption under section 3(g) of the Act.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Exemption under section 3(g) of the Act... FOREIGN AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.306 Exemption under section 3(g) of the Act. For the purpose of section 3(g) of the Act— (a) Attempts to influence or persuade agency personnel or...

28 CFR 5.306 - Exemption under section 3(g) of the Act.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Exemption under section 3(g) of the Act... FOREIGN AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.306 Exemption under section 3(g) of the Act. For the purpose of section 3(g) of the Act— (a) Attempts to influence or persuade agency personnel or...

28 CFR 5.306 - Exemption under section 3(g) of the Act.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Exemption under section 3(g) of the Act... FOREIGN AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.306 Exemption under section 3(g) of the Act. For the purpose of section 3(g) of the Act— (a) Attempts to influence or persuade agency personnel or...

28 CFR 5.306 - Exemption under section 3(g) of the Act.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Exemption under section 3(g) of the Act... FOREIGN AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.306 Exemption under section 3(g) of the Act. For the purpose of section 3(g) of the Act— (a) Attempts to influence or persuade agency personnel or...

28 CFR 5.306 - Exemption under section 3(g) of the Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Exemption under section 3(g) of the Act... FOREIGN AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.306 Exemption under section 3(g) of the Act. For the purpose of section 3(g) of the Act— (a) Attempts to influence or persuade agency personnel or...

40 CFR 51.904 - How do the classification and attainment date provisions in section 172(a) of subpart 1 of the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... attainment date provisions in section 172(a) of subpart 1 of the CAA apply to areas subject to § 51.902(b... attainment date provisions in section 172(a) of subpart 1 of the CAA apply to areas subject to § 51.902(b)? (a) Classification. The Administrator may classify an area subject to § 51.902(b) as an overwhelming...

40 CFR 51.904 - How do the classification and attainment date provisions in section 172(a) of subpart 1 of the...

Code of Federal Regulations, 2014 CFR

2014-07-01

... attainment date provisions in section 172(a) of subpart 1 of the CAA apply to areas subject to § 51.902(b... attainment date provisions in section 172(a) of subpart 1 of the CAA apply to areas subject to § 51.902(b)? (a) Classification. The Administrator may classify an area subject to § 51.902(b) as an overwhelming...

40 CFR 51.904 - How do the classification and attainment date provisions in section 172(a) of subpart 1 of the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... attainment date provisions in section 172(a) of subpart 1 of the CAA apply to areas subject to § 51.902(b... attainment date provisions in section 172(a) of subpart 1 of the CAA apply to areas subject to § 51.902(b)? (a) Classification. The Administrator may classify an area subject to § 51.902(b) as an overwhelming...

40 CFR 51.904 - How do the classification and attainment date provisions in section 172(a) of subpart 1 of the...

Code of Federal Regulations, 2013 CFR

2013-07-01

... attainment date provisions in section 172(a) of subpart 1 of the CAA apply to areas subject to § 51.902(b... attainment date provisions in section 172(a) of subpart 1 of the CAA apply to areas subject to § 51.902(b)? (a) Classification. The Administrator may classify an area subject to § 51.902(b) as an overwhelming...

40 CFR 51.904 - How do the classification and attainment date provisions in section 172(a) of subpart 1 of the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... attainment date provisions in section 172(a) of subpart 1 of the CAA apply to areas subject to § 51.902(b... attainment date provisions in section 172(a) of subpart 1 of the CAA apply to areas subject to § 51.902(b)? (a) Classification. The Administrator may classify an area subject to § 51.902(b) as an overwhelming...

Rocky Flats CAAS System Recalibrated, Retested, and Analyzed to Install in the Criticality Experiments Facility at the Nevada Test Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, S; Heinrichs, D; Biswas, D

2009-05-27

Neutron detectors and control panels transferred from the Rocky Flats Plant (RFP) were recalibrated and retested for redeployment to the CEF. Testing and calibration were successful with no failure to any equipment. Detector sensitivity was tested at a TRIGA reactor, and the response to thermal neutron flux was satisfactory. MCNP calculated minimum fission yield ({approx} 2 x 10{sup 15} fissions) was applied to determine the thermal flux at selected detector positions at the CEF. Thermal flux levels were greater than 6.39 x 10{sup 6} (n/cm{sup 2}-sec), which was about four orders of magnitude greater than the minimum alarm flux. Calculationsmore » of detector survivable distances indicate that, to be out of lethal area, a detector needs to be placed greater than 15 ft away from a maximum credible source. MCNP calculated flux/dose results were independently verified by COG. CAAS calibration and the testing confirmed that the RFP CAAS system is performing its functions as expected. New criteria for the CAAS detector placement and 12-rad zone boundaries at the CEF are established. All of the CAAS related documents and hardware have been transferred from LLNL to NSTec for installation at the CEF high bay areas.« less

77 FR 21911 - Approval and Promulgation of Implementation Plans; State of Arizona; Prevention of Air Pollution...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-12

... Promulgation of Implementation Plans; State of Arizona; Prevention of Air Pollution Emergency Episodes AGENCY... pollution emergency episodes in Clean Air Act (CAA or Act) section 110(a)(2)(G). Section 110(a)(2)(G) of the... applicable, including section 110(a)(2)(G) regarding authority to address air pollution emergency episodes...

Characterization of CAA0225, a novel inhibitor specific for cathepsin L, as a probe for autophagic proteolysis.

PubMed

Takahashi, Katsuyuki; Ueno, Takashi; Tanida, Isei; Minematsu-Ikeguchi, Naoko; Murata, Mitsuo; Kominami, Eiki

2009-03-01

We screened a series of new epoxysuccinyl peptides for the development of a lysosomal cathepsin L-specific inhibitor. Among the compounds tested, (2S,3S)-oxirane-2,3-dicarboxylic acid 2-[((S)-1-benzylcarbamoyl-2-phenyl-ethyl)-amide] 3-{[2-(4-hydroxy-phenyl)-ethyl]-amide} (compound CAA0225) was the most potent inhibitor of cathepsin L. CAA0225 inhibited rat liver cathepsin L with IC50 values of 1.9 nM, but not rat liver cathepsin B (IC50, >1000-5000 nM). To assess the contribution of cathepsin L to lysosomal proteolysis, we evaluated autophagy, which is the process of lysosomal self-degradation of cell constituents. In HeLa and Huh-7 cells cultured under nutrient-deprived conditions CAA0225 significantly inhibited degradation of long-lived proteins; however, the magnitude of inhibition was comparable to that in the presence of CA-074-OMe, which is a cathepsin B-specific inhibitor. Thus the contributions of cathepsin L and cathepsin B to autophagic protein degradation of cytoplasmic proteins are nearly equal. During autophagy, microtubule-associated protein IA/IB light chain 3-II (LC3-II) and gamma-aminobutyric acid (A) receptor-associated protein (GABARAP)-II, which are specific markers of autophagosomal membranes that engulf cytoplasmic components, also undergo degradation upon fusion of autophagosomes with lysosomes. CAA0225 effectively inhibited degradation of LC3-II and GABARAP, whereas CA-074-OMe had only a marginal effect on their levels. Therefore we conclude that cathepsin L does not play a general role in the degradation of proteins in the lumen of autophagosomes, but rather is involved specifically in the degradation of autophagosomal membrane markers.

16 CFR 300.35 - Hearings under section 4(d) of the act.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Hearings under section 4(d) of the act. 300.35 Section 300.35 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS RULES AND REGULATIONS UNDER THE WOOL PRODUCTS LABELING ACT OF 1939 General § 300.35 Hearings under...

Pesticide Active Ingredient Production Industry: National Emission Standards for Hazardous Air Pollutants (NESHAP)

EPA Pesticide Factsheets

This action promulgates national emission standards for hazardous air pollutants (NESHAP) for the pesticide active ingredient (PAI) production source category under section 112 of the Clean Air Act as amended (CAA or Act).

77 FR 61279 - Approval and Promulgation of Implementation Plans; Mississippi; 110(a)(2)(G) Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-09

... section 110(a)(2)(G). EPA's July 31, 2012 (77 FR 45320), proposed approval was contingent upon Mississippi.... This SIP revision was submitted to address Clean Air Act (CAA or Act) section 110(a)(2)(G). Specifically, EPA is approving Mississippi's July 26, 2012, submission addressing section 110(a)(2)(G), of the...

75 FR 50711 - Approval and Promulgation of Air Quality Implementation Plans; Ohio; Final Approval and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-17

... conditional approval of portions of OAC rule 3745-21-09. You can learn more information about the rule...). ACTION: Final rule. SUMMARY: Under section 110(k)(3) of the Clean Air Act (CAA), EPA is disapproving an...) of the CAA, we are also conditionally approving a revision of paragraph (BBB)(1) of OAC 3745-21-09...

Association of the GGCX (CAA)16/17 repeat polymorphism with higher warfarin dose requirements in African Americans.

PubMed

Cavallari, Larisa H; Perera, Minoli; Wadelius, Mia; Deloukas, Panos; Taube, Gelson; Patel, Shitalben R; Aquino-Michaels, Keston; Viana, Marlos A G; Shapiro, Nancy L; Nutescu, Edith A

2012-02-01

Little is known about genetic contributors to higher than usual warfarin dose requirements, particularly for African Americans. This study tested the hypothesis that the γ-glutamyl carboxylase (GGCX) genotype contributes to warfarin dose requirements greater than 7.5 mg/day in an African American population. A total of 338 African Americans on a stable dose of warfarin were enrolled. The GGCX rs10654848 (CAA)n, rs12714145 (G>A), and rs699664 (p.R325Q); VKORC1 c.-1639G>A and rs61162043; and CYP2C9*2, *3, *5, *8, *11, and rs7089580 genotypes were tested for their association with dose requirements greater than 7.5 mg/day alone and in the context of other variables known to influence dose variability. The GGCX rs10654848 (CAA)16 or 17 repeat occurred at a frequency of 2.6% in African Americans and was overrepresented among patients requiring greater than 7.5 mg/day versus those who required lower doses (12 vs. 3%, P=0.003; odds ratio 4.0, 95% confidence interval, 1.5-10.5). The GGCX rs10654848 genotype remained associated with high dose requirements on regression analysis including age, body size, and VKORC1 genotype. On linear regression, the GGCX rs10654848 genotype explained 2% of the overall variability in warfarin dose in African Americans. An examination of the GGCX rs10654848 genotype in warfarin-treated Caucasians revealed a (CAA)16 repeat frequency of only 0.27% (P=0.008 compared with African Americans). These data support the GGCX rs10654848 genotype as a predictor of higher than usual warfarin doses in African Americans, who have a 10-fold higher frequency of the (CAA)16/17 repeat compared with Caucasians.

Insights into the molecular mechanism of tolerance to carboxylic acid amide (CAA) fungicides in Pythium aphanidermatum.

PubMed

Blum, Mathias; Gisi, Ulrich

2012-08-01

Tolerance to the oomycete-specific carboxylic acid amide (CAA) fungicides is a poorly understood mechanism in Pythium species. The root-rot and damping-off causative agent Pythium aphanidermatum and the CAA fungicide mandipropamid (MPD) were used to investigate the molecular basis of CAA tolerance. Five genes putatively involved in carbohydrate synthesis were identified and characterised: one chitin synthase gene, PaChs, and four cellulose synthase genes PaCesA1 to PaCesA4, of which PaCesA3 encodes the MPD target enzyme. These genes were differentially expressed throughout the life cycle of P. aphanidermatum. Mycelium treated with MPD concentrations slightly affecting mycelial growth did not cause a change in PaCesA3 expression nor a strong upregulation of PaCesA homologues. The high tolerance level of P. aphanidermatum and the lack of PaCesA upregulation imply that MPD tolerance is the result of a specific amino acid configuration in the cellulose synthase 3 (CesA3) target enzyme. Indeed, P. aphanidermatum displays the amino acid L1109 which is also associated with MPD resistance in artificial mutants of Phytophthora species. It is concluded that MPD tolerance in P. aphanidermatum is not caused by compensatory mechanisms but most likely by an inherent target-site configuration in PaCesA3 that hinders MPD binding to the enzyme pocket. Copyright © 2012 Society of Chemical Industry.

10 CFR 8.2 - Interpretation of Price-Anderson Act, section 170 of the Atomic Energy Act of 1954.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Interpretation of Price-Anderson Act, section 170 of the Atomic Energy Act of 1954. 8.2 Section 8.2 Energy NUCLEAR REGULATORY COMMISSION INTERPRETATIONS § 8.2... in Nuclear Energy 75 (1959). In the testimony before the Joint Committee last year, Professor Samuel...

10 CFR 8.2 - Interpretation of Price-Anderson Act, section 170 of the Atomic Energy Act of 1954.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Interpretation of Price-Anderson Act, section 170 of the Atomic Energy Act of 1954. 8.2 Section 8.2 Energy NUCLEAR REGULATORY COMMISSION INTERPRETATIONS § 8.2... in Nuclear Energy 75 (1959). In the testimony before the Joint Committee last year, Professor Samuel...

PolyQ repeat expansions in ATXN2 associated with ALS are CAA interrupted repeats.

PubMed

Yu, Zhenming; Zhu, Yongqing; Chen-Plotkin, Alice S; Clay-Falcone, Dana; McCluskey, Leo; Elman, Lauren; Kalb, Robert G; Trojanowski, John Q; Lee, Virginia M-Y; Van Deerlin, Vivianna M; Gitler, Aaron D; Bonini, Nancy M

2011-03-29

Amyotrophic lateral sclerosis (ALS) is a devastating, rapidly progressive disease leading to paralysis and death. Recently, intermediate length polyglutamine (polyQ) repeats of 27-33 in ATAXIN-2 (ATXN2), encoding the ATXN2 protein, were found to increase risk for ALS. In ATXN2, polyQ expansions of ≥ 34, which are pure CAG repeat expansions, cause spinocerebellar ataxia type 2. However, similar length expansions that are interrupted with other codons, can present atypically with parkinsonism, suggesting that configuration of the repeat sequence plays an important role in disease manifestation in ATXN2 polyQ expansion diseases. Here we determined whether the expansions in ATXN2 associated with ALS were pure or interrupted CAG repeats, and defined single nucleotide polymorphisms (SNPs) rs695871 and rs695872 in exon 1 of the gene, to assess haplotype association. We found that the expanded repeat alleles of 40 ALS patients and 9 long-repeat length controls were all interrupted, bearing 1-3 CAA codons within the CAG repeat. 21/21 expanded ALS chromosomes with 3CAA interruptions arose from one haplotype (GT), while 18/19 expanded ALS chromosomes with <3CAA interruptions arose from a different haplotype (CC). Moreover, age of disease onset was significantly earlier in patients bearing 3 interruptions vs fewer, and was distinct between haplotypes. These results indicate that CAG repeat expansions in ATXN2 associated with ALS are uniformly interrupted repeats and that the nature of the repeat sequence and haplotype, as well as length of polyQ repeat, may play a role in the neurological effect conferred by expansions in ATXN2.

The chloroplast division mutant caa33 of Arabidopsis thaliana reveals a crucial impact of chloroplast homeostasis on stress acclimation and retrograde plastid-to-nucleus signaling

PubMed Central

Šimková, Klára; Kim, Chanhong; Gacek, Katarzyna; Baruah, Aiswarya; Laloi, Christophe; Apel, Klaus

2011-01-01

SUMMARY Retrograde plastid-to-nucleus signaling tightly controls and coordinates nuclear and plastid gene expression that is required for plastid biogenesis and chloroplast activities. As chloroplasts act as sensors of environmental changes, plastid-derived signaling also modulates stress responses of plants by transferring stress-related signals and altering nuclear gene expression. Various mutant screens have been undertaken to identify constituents of plastid signaling pathways. Almost all mutations identified in these screens have in common that they target plastid-specific but not extra-plastidic functions. They have been suggested to define either genuine constituents of retrograde signaling pathways or components required for the synthesis of plastid signals. Here we report the characterization of the caa33 (constitutive activator of AAA-ATPase) mutant, which reveals another way of how mutations that affect plastid functions may modulate retrograde plastid signaling. caa33 disturbs a plastid-specific function by impeding plastid division thereby perturbing plastid homeostasis. This results in pre-conditioning plants by activating the expression of stress genes, enhancing pathogen resistance and attenuating the plant’s capacity to respond to plastid signals. Our study reveals an intimate link between chloroplast activity and the plant’s susceptibility to stress and emphasizes the need to consider the possible impact of pre-conditioning on retrograde plastid-to-nucleus signaling. PMID:22014227

Factors associated with ATXN2 CAG/CAA repeat intergenerational instability in Spinocerebellar Ataxia type 2.

PubMed

Almaguer-Mederos, L E; Mesa, J M L; González-Zaldívar, Y; Almaguer-Gotay, D; Cuello-Almarales, D; Aguilera-Rodríguez, R; Falcón, N S; Gispert, S; Auburger, G; Velázquez-Pérez, L

2018-05-14

Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disorder caused by the unstable expansion of a CAG/CAA repeat in the ATXN2 gene, which normally encodes 22 glutamines (Q22). A large study was conducted to characterize the CAG/CAA repeat intergenerational instability in SCA2 families. Large normal alleles (LNA, Q24-31) were significantly more unstable upon maternal transmissions. In contrast, expanded alleles (EA, Q32-750) were significantly more unstable during paternal transmissions, in correlation with repeat length. Significant correlations were found between the instability and the age at conception in paternal transmissions. In conclusion, intergenerational instability at ATXN2 locus is influenced by the sex, repeat length and age at conception of the transmitting parent. These results have profound implications for genetic counseling services. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

The Correlation Between Pre and Postoperative Hearing Level with High Resolution Computed Tomography (HRCT) Findings in Congenital Canal Atresia (CAA) Patients.

PubMed

Asma, A; Abdul Fatah, A W; Hamzaini, A H; Mazita, A

2013-12-01

In managing patient with congenital congenital aural atresia (CAA), preoperative high resolution computed tomography (HRCT) scan and hearing assessment are important. A grading system based on HRCT findings was first introduced by Jahrsdoefer in order to select appropriate candidates for operation and to predict the postoperative hearing outcome in CAA patients. The score of eight and more was considered as a good prognostic factor for hearing reconstruction surgery. However previously in our center this score was not used as the criteria for surgical procedure. This study was conducted at Center A to evaluate the correlation between pre and postoperative hearing level with HRCT based on a Jahrsdoefer grading system in patients with CAA. All records and HRCT films with CAA from January 1997 until December 2007 at Center A were evaluated. The demographic data, operative records, pre and post operative hearing levels and HRCT findings were analyzed. Hearing level in this study was based on a pure tone average of air-bone gap at 500 Hz, 1 kHz and 2 kHz or hearing level obtained from auditory brainstem response eudiometry. This study was approved by Research Ethics Committee (code number, FF-197-2008). Thirty-two ears were retrospectively evaluated. The postoperative hearing level of 30 dB and less was considered as successful hearing result postoperatively. Of the six ears which underwent canalplasty, three had achieved successful hearing result. However, there was no significant correlation between preoperative hearing level (HL) with HRCT score and postoperative HL with HRCT score at 0.05 significant levels (correlation coefficient = -0.292, P = 0.105 and correlation coefficient = -0.127, P = 0.810) respectively. Hearing evaluation and HRCT temporal bone are two independent evaluations for the patients with CAA before going for hearing reconstructive surgery.

12 CFR 250.220 - Whether member bank acting as trustee is prohibited by section 20 of the Banking Act of 1933 from...

Code of Federal Regulations, 2011 CFR

2011-01-01

... prohibited by section 20 of the Banking Act of 1933 from acquiring majority of shares of mutual fund. 250.220... trustee is prohibited by section 20 of the Banking Act of 1933 from acquiring majority of shares of mutual fund. (a) The Board recently considered whether section 20 of the Banking Act of 1933 (12 U.S.C. 377...

12 CFR 250.220 - Whether member bank acting as trustee is prohibited by section 20 of the Banking Act of 1933 from...

Code of Federal Regulations, 2010 CFR

2010-01-01

... prohibited by section 20 of the Banking Act of 1933 from acquiring majority of shares of mutual fund. 250.220... trustee is prohibited by section 20 of the Banking Act of 1933 from acquiring majority of shares of mutual fund. (a) The Board recently considered whether section 20 of the Banking Act of 1933 (12 U.S.C. 377...

16 CFR 1611.39 - Shipments under section 11(c) of the act.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Shipments under section 11(c) of the act. 1611.39 Section 1611.39 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY OF VINYL PLASTIC FILM Rules and Regulations § 1611.39 Shipments...

Section 609 of the Clean Air Act: MVAC

EPA Pesticide Factsheets

Fact sheet provides a general overview of EPA regulations under Section 609 of the Clean Air Act, which is focused on preventing the release of refrigerants during the servicing of motor vehicle air-conditioning systems and similar appliances.

Comprehensive Headstart, Child Development, and Family Services Act of 1972: Bill Text and Section-by-Section Analysis.

ERIC Educational Resources Information Center

Nelson, Gaylord; And Others

The context of the Comprehensive Headstart, Child Development, and Family Services Act of 1972 is presented along with a section-by-section analysis of it. Section 1 is the title. Section 2 is a statement of findings and purpose. Section 3 authorizes appropriations. Title I describes Headstart, Child Development and Family Services Programs which…

Comparison of the Effects of the US Clean Air Act and of Smoking Prevention and Cessation Efforts on the Risk of Acute Myelogenous Leukemia

PubMed Central

Liu, Yan; Wu, Felicia; Lioy, Paul

2011-01-01

Objectives. We used 2 approaches based on published information to compare the impacts on leukemia incidence and benzene exposure of the 1990 US Clean Air Act (CAA) amendments and smoking prevention and cessation efforts. Methods. We extrapolated leukemia mortality related to community air pollution levels and to cigarette smoking from data from the US Environmental Protection Agency and the US Surgeon General. We also estimated relative decline in total exposures to benzene (a known human leukemogen) owing to the CAA amendments and to smoking prevention and cessation efforts. Results. We estimated that because of the CAA, there will be approximately 300 fewer leukemia deaths in the United States during the period 2000 through 2020. During the closest comparable period (1987–2007), we estimated that decline in cigarette smoking led to 7120 fewer leukemia deaths, of which 1282 to 3702 were attributable to benzene. Similarly, the decline in smoking led to about a tenfold greater decrease in total-population benzene exposure than did the 1990 CAA amendments. Conclusions. Both the CAA and smoking cessation activities contribute to a decrease in leukemia incidence. Smoking cessation activities have had a greater effect in the past. PMID:22021318

Comparison of the effects of the US Clean Air Act and of smoking prevention and cessation efforts on the risk of acute myelogenous leukemia.

PubMed

Goldstein, Bernard D; Liu, Yan; Wu, Felicia; Lioy, Paul

2011-12-01

We used 2 approaches based on published information to compare the impacts on leukemia incidence and benzene exposure of the 1990 US Clean Air Act (CAA) amendments and smoking prevention and cessation efforts. We extrapolated leukemia mortality related to community air pollution levels and to cigarette smoking from data from the US Environmental Protection Agency and the US Surgeon General. We also estimated relative decline in total exposures to benzene (a known human leukemogen) owing to the CAA amendments and to smoking prevention and cessation efforts. We estimated that because of the CAA, there will be approximately 300 fewer leukemia deaths in the United States during the period 2000 through 2020. During the closest comparable period (1987-2007), we estimated that decline in cigarette smoking led to 7120 fewer leukemia deaths, of which 1282 to 3702 were attributable to benzene. Similarly, the decline in smoking led to about a tenfold greater decrease in total-population benzene exposure than did the 1990 CAA amendments. Both the CAA and smoking cessation activities contribute to a decrease in leukemia incidence. Smoking cessation activities have had a greater effect in the past.

78 FR 2992 - Agency Information Collection Activities; Proposed Collection; Comment Request; Distribution of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-15

... Activities; Proposed Collection; Comment Request; Distribution of Offsite Consequence Analysis Information... Collection Request (ICR), Distribution of Offsite Consequence Analysis Information under Section 112(r)(7)(H... Air Act Section 112(r)(7); Distribution of Off-Site Consequence Analysis Information. CAA section 112...

78 FR 62629 - Proposed Information Collection Request; Comment Request; Clean Water Act Section 404 State...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-22

... comments to OMB. Abstract: Section 404(g) of the Clean Water Act authorizes States [and Tribes] to assume... States/Tribes requesting assumption of the Clean Water Act section 404 permit program; States/ [[Page... Collection Request; Comment Request; Clean Water Act Section 404 State-Assumed Programs (Renewal) AGENCY...

Notification: Background Investigation Services EPA’s Efforts to Incorporate Environmental Justice Into Clean Air Act Inspections for Air Toxics

EPA Pesticide Factsheets

Project #OPE-FY14-0017, March 7, 2014. The OIG plans to begin the preliminary research phase of an evaluation of the EPA's efforts to incorporate environmental justice into Clean Air Act (CAA) inspections for air toxics.

Student Access: Section 504 of the Rehabilitation Act of 1973.

ERIC Educational Resources Information Center

Oregon State Dept. of Education, Salem.

This paper addresses educational implications of Section 504 of the Rehabilitation Act of 1973 which prohibits programs receiving federal financial assistance from denying services to or discriminating against individuals with disabilities. Individual sections cover: legal definitions (e.g., "individual with handicaps" and…

76 FR 20664 - Clean Water Act Section 303(d): Availability of List Decisions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9294-5] Clean Water Act Section 303(d): Availability of List... notice announces the availability of EPA's action identifying water quality limited segments and associated pollutants in Louisiana to be listed pursuant to Clean Water Act Section 303(d), and request for...

75 FR 52735 - Clean Water Act Section 303(d): Availability of List Decisions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-27

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9189-7] Clean Water Act Section 303(d): Availability of List...: This notice announces the availability of EPA's decision identifying 12 water quality limited waterbodies and associated pollutants in South Dakota to be listed pursuant to the Clean Water Act Section 303...

77 FR 27770 - Clean Water Act Section 303(d): Availability of List Decisions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-11

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9670-5] Clean Water Act Section 303(d): Availability of List...: This notice announces EPA's decision identifying certain water quality limited waterbodies, and the associated pollutant, in Utah to be listed pursuant to the Clean Water Act Section 303(d)(2), and requests...

29 CFR 1626.12 - Conciliation efforts pursuant to section 7(d) of the Act.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 4 2012-07-01 2012-07-01 false Conciliation efforts pursuant to section 7(d) of the Act. 1626.12 Section 1626.12 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.12 Conciliation efforts pursuant to section...

29 CFR 1626.12 - Conciliation efforts pursuant to section 7(d) of the Act.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 4 2014-07-01 2014-07-01 false Conciliation efforts pursuant to section 7(d) of the Act. 1626.12 Section 1626.12 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.12 Conciliation efforts pursuant to section...

29 CFR 1626.12 - Conciliation efforts pursuant to section 7(d) of the Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false Conciliation efforts pursuant to section 7(d) of the Act. 1626.12 Section 1626.12 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.12 Conciliation efforts pursuant to section...

29 CFR 1626.12 - Conciliation efforts pursuant to section 7(d) of the Act.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 4 2013-07-01 2013-07-01 false Conciliation efforts pursuant to section 7(d) of the Act. 1626.12 Section 1626.12 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.12 Conciliation efforts pursuant to section...

29 CFR 1626.12 - Conciliation efforts pursuant to section 7(d) of the Act.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 4 2011-07-01 2011-07-01 false Conciliation efforts pursuant to section 7(d) of the Act. 1626.12 Section 1626.12 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.12 Conciliation efforts pursuant to section...

Least-Squares Spectral Element Solutions to the CAA Workshop Benchmark Problems

NASA Technical Reports Server (NTRS)

Lin, Wen H.; Chan, Daniel C.

1997-01-01

This paper presents computed results for some of the CAA benchmark problems via the acoustic solver developed at Rocketdyne CFD Technology Center under the corporate agreement between Boeing North American, Inc. and NASA for the Aerospace Industry Technology Program. The calculations are considered as benchmark testing of the functionality, accuracy, and performance of the solver. Results of these computations demonstrate that the solver is capable of solving the propagation of aeroacoustic signals. Testing of sound generation and on more realistic problems is now pursued for the industrial applications of this solver. Numerical calculations were performed for the second problem of Category 1 of the current workshop problems for an acoustic pulse scattered from a rigid circular cylinder, and for two of the first CAA workshop problems, i. e., the first problem of Category 1 for the propagation of a linear wave and the first problem of Category 4 for an acoustic pulse reflected from a rigid wall in a uniform flow of Mach 0.5. The aim for including the last two problems in this workshop is to test the effectiveness of some boundary conditions set up in the solver. Numerical results of the last two benchmark problems have been compared with their corresponding exact solutions and the comparisons are excellent. This demonstrates the high fidelity of the solver in handling wave propagation problems. This feature lends the method quite attractive in developing a computational acoustic solver for calculating the aero/hydrodynamic noise in a violent flow environment.

Report: EPA Relying on Existing Clean Air Act Regulations to Reduce Atmospheric Deposition to the Chesapeake Bay and its Watershed

EPA Pesticide Factsheets

Report #2007-P-00009, February 28, 2007. EPA’s Chesapeake Bay Program Office is relying on anticipated nitrogen deposition reductions from Clean Air Act (CAA) regulations already issued by EPA, combined with other non-air sources' anticipated reductions.

29 CFR 1990.151 - Model standard pursuant to section 6(b) of the Act.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 9 2014-07-01 2014-07-01 false Model standard pursuant to section 6(b) of the Act. 1990... OCCUPATIONAL CARCINOGENS Model Standards § 1990.151 Model standard pursuant to section 6(b) of the Act. Occupational Exposure to ________ Permanent Standard (insert section number of standard) (a) Scope and...

29 CFR 1990.151 - Model standard pursuant to section 6(b) of the Act.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 9 2013-07-01 2013-07-01 false Model standard pursuant to section 6(b) of the Act. 1990... OCCUPATIONAL CARCINOGENS Model Standards § 1990.151 Model standard pursuant to section 6(b) of the Act. Occupational Exposure to ________ Permanent Standard (insert section number of standard) (a) Scope and...

29 CFR 1990.151 - Model standard pursuant to section 6(b) of the Act.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 9 2012-07-01 2012-07-01 false Model standard pursuant to section 6(b) of the Act. 1990... OCCUPATIONAL CARCINOGENS Model Standards § 1990.151 Model standard pursuant to section 6(b) of the Act. Occupational Exposure to ________ Permanent Standard (insert section number of standard) (a) Scope and...

29 CFR 785.34 - Effect of section 4 of the Portal-to-Portal Act.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 3 2014-07-01 2014-07-01 false Effect of section 4 of the Portal-to-Portal Act. 785.34... of Principles Traveltime § 785.34 Effect of section 4 of the Portal-to-Portal Act. The Portal Act... employee and activities that are incidental to the use of such vehicle for commuting are not considered...

29 CFR 785.34 - Effect of section 4 of the Portal-to-Portal Act.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 3 2011-07-01 2011-07-01 false Effect of section 4 of the Portal-to-Portal Act. 785.34... of Principles Traveltime § 785.34 Effect of section 4 of the Portal-to-Portal Act. The Portal Act... employee and activities that are incidental to the use of such vehicle for commuting are not considered...

29 CFR 785.34 - Effect of section 4 of the Portal-to-Portal Act.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 3 2013-07-01 2013-07-01 false Effect of section 4 of the Portal-to-Portal Act. 785.34... of Principles Traveltime § 785.34 Effect of section 4 of the Portal-to-Portal Act. The Portal Act... employee and activities that are incidental to the use of such vehicle for commuting are not considered...

29 CFR 785.34 - Effect of section 4 of the Portal-to-Portal Act.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 3 2012-07-01 2012-07-01 false Effect of section 4 of the Portal-to-Portal Act. 785.34... of Principles Traveltime § 785.34 Effect of section 4 of the Portal-to-Portal Act. The Portal Act... employee and activities that are incidental to the use of such vehicle for commuting are not considered...

CAA for Jet Noise Physics: Issues and Recent Progress

NASA Technical Reports Server (NTRS)

Mankbadi, Reda

2001-01-01

Dr. Mankbadi summarized recent CAA results. Examples of the effect of various boundary condition schemes on the computed acoustic field, for a point source in a uniform flow, were shown. Solutions showing the impact of inflow excitations on the result were also shown. Results from a large eddy simulation, using a fourth-order MacCormack scheme with a Smagorinsky sub-grid turbulence model, were shown for a Mach 2.1 unheated jet. The results showed that the results were free from spurious modes. Results were shown for a Mach 1.4 jet using LES in the near field and the Kirchhoff method for the far field. Predicted flow field characteristics were shown to be in good agreement with data and predicted far field directivities were shown to be in qualitative agree with experimental measurements.

Toxic Substances Control Act Section 8(e): Frequent Questions

EPA Pesticide Factsheets

Section 8(e) of the Toxic Substances Control Act (TSCA) requires notification to EPA of information that reasonably supports the conclusion that their substances or mixtures presents a substantial risk of injury to health or the environment.

A modular Human Exposure Model (HEM) framework to characterize near-field chemical exposure in LCIA and CAA

EPA Science Inventory

Life Cycle Impact Analysis (LCIA) has proven to be a valuable tool for systematically comparing processes and products, and has been proposed for use in Chemical Alternatives Analysis (CAA). The exposure assessment portion of the human health impact scores of LCIA has historicall...

26 CFR 303.1 - Statutory provisions; section 36, Trading With the Enemy Act.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 18 2011-04-01 2011-04-01 false Statutory provisions; section 36, Trading With... TREASURY (CONTINUED) PROCEDURE AND ADMINISTRATION TAXES UNDER THE TRADING WITH THE ENEMY ACT § 303.1 Statutory provisions; section 36, Trading With the Enemy Act. Sec. 36 (a) The vesting in or transfer to the...

40 CFR 91.1003 - Exclusions based on section 216(10) of the Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Exclusion and Exemption of Marine SI Engines § 91.1003 Exclusions based on section 216(10) of the Act. (a) For the purpose of determining the applicability of section 216(10) of the Act, any marine SI engine as that term is...

26 CFR 303.1 - Statutory provisions; section 36, Trading With the Enemy Act.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 26 Internal Revenue 18 2014-04-01 2014-04-01 false Statutory provisions; section 36, Trading With... TREASURY (CONTINUED) PROCEDURE AND ADMINISTRATION TAXES UNDER THE TRADING WITH THE ENEMY ACT § 303.1 Statutory provisions; section 36, Trading With the Enemy Act. Sec. 36 (a) The vesting in or transfer to the...

26 CFR 303.1 - Statutory provisions; section 36, Trading With the Enemy Act.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 26 Internal Revenue 18 2012-04-01 2012-04-01 false Statutory provisions; section 36, Trading With... TREASURY (CONTINUED) PROCEDURE AND ADMINISTRATION TAXES UNDER THE TRADING WITH THE ENEMY ACT § 303.1 Statutory provisions; section 36, Trading With the Enemy Act. Sec. 36 (a) The vesting in or transfer to the...

26 CFR 303.1 - Statutory provisions; section 36, Trading With the Enemy Act.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 26 Internal Revenue 18 2013-04-01 2013-04-01 false Statutory provisions; section 36, Trading With... TREASURY (CONTINUED) PROCEDURE AND ADMINISTRATION TAXES UNDER THE TRADING WITH THE ENEMY ACT § 303.1 Statutory provisions; section 36, Trading With the Enemy Act. Sec. 36 (a) The vesting in or transfer to the...

26 CFR 303.1 - Statutory provisions; section 36, Trading With the Enemy Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Statutory provisions; section 36, Trading With... TREASURY (CONTINUED) PROCEDURE AND ADMINISTRATION TAXES UNDER THE TRADING WITH THE ENEMY ACT § 303.1 Statutory provisions; section 36, Trading With the Enemy Act. Sec. 36 (a) The vesting in or transfer to the...

17 CFR 201.550 - Summary suspensions pursuant to Exchange Act Section 12(k)(1)(A).

Code of Federal Regulations, 2012 CFR

2012-04-01

... to Exchange Act Section 12(k)(1)(A). 201.550 Section 201.550 Commodity and Securities Exchanges... Suspensions § 201.550 Summary suspensions pursuant to Exchange Act Section 12(k)(1)(A). (a) Petition for termination of suspension. Any person adversely affected by a suspension pursuant to Section 12(k)(1)(A) of...

17 CFR 201.550 - Summary suspensions pursuant to Exchange Act Section 12(k)(1)(A).

Code of Federal Regulations, 2013 CFR

2013-04-01

... to Exchange Act Section 12(k)(1)(A). 201.550 Section 201.550 Commodity and Securities Exchanges... Suspensions § 201.550 Summary suspensions pursuant to Exchange Act Section 12(k)(1)(A). (a) Petition for termination of suspension. Any person adversely affected by a suspension pursuant to Section 12(k)(1)(A) of...

17 CFR 201.550 - Summary suspensions pursuant to Exchange Act Section 12(k)(1)(A).

Code of Federal Regulations, 2011 CFR

2011-04-01

... to Exchange Act Section 12(k)(1)(A). 201.550 Section 201.550 Commodity and Securities Exchanges... Suspensions § 201.550 Summary suspensions pursuant to Exchange Act Section 12(k)(1)(A). (a) Petition for termination of suspension. Any person adversely affected by a suspension pursuant to Section 12(k)(1)(A) of...

17 CFR 201.550 - Summary suspensions pursuant to Exchange Act Section 12(k)(1)(A).

Code of Federal Regulations, 2014 CFR

2014-04-01

... to Exchange Act Section 12(k)(1)(A). 201.550 Section 201.550 Commodity and Securities Exchanges... Suspensions § 201.550 Summary suspensions pursuant to Exchange Act Section 12(k)(1)(A). (a) Petition for termination of suspension. Any person adversely affected by a suspension pursuant to Section 12(k)(1)(A) of...

Clean Water Act Section 404(q):Memorandum of Agreement

EPA Pesticide Factsheets

A memorandum of agreement between EPA and the Army Corps of Engineers to minimize, to the maximum extent practicable, duplication, needless paperwork and delays in the issuance of permits related to Section 404(q) of the Clean Water Act.

2 CFR 176.190 - Award term-Wage rate requirements under Section 1606 of the Recovery Act.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Section 1606 of the Recovery Act. 176.190 Section 176.190 Grants and Agreements Office of Management and... AMERICAN RECOVERY AND REINVESTMENT ACT OF 2009, PUBLIC LAW 111-5 Wage Rate Requirements Under Section 1606 of the American Recovery and Reinvestment Act of 2009 § 176.190 Award term—Wage rate requirements...

2 CFR 176.190 - Award term-Wage rate requirements under Section 1606 of the Recovery Act.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Section 1606 of the Recovery Act. 176.190 Section 176.190 Grants and Agreements Office of Management and... AMERICAN RECOVERY AND REINVESTMENT ACT OF 2009, PUBLIC LAW 111-5 Wage Rate Requirements Under Section 1606 of the American Recovery and Reinvestment Act of 2009 § 176.190 Award term—Wage rate requirements...

77 FR 55419 - Approval and Promulgation of Air Quality Implementation Plans; Delaware; Section 110(a)(2...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-10

... the 2008 Lead National Ambient Air Quality Standards AGENCY: Environmental Protection Agency (EPA...) of the Clean Air Act (CAA), necessary to implement, maintain, and enforce the 2008 lead national..., necessary to implement, maintain, and enforce the 2008 lead NAAQS. II. Summary of SIP Revision On October 17...

76 FR 51398 - Notice of Proposed Partial Consent Decree Under the Comprehensive Environmental Response...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-18

... Environmental Response, Compensation, and Liability Act and the Clean Air Act Notice is hereby given that on....C. 9607, and Sections 112(r) and 114(a) of the Clean Air Act (``CAA''), 42 U.S.C. 7412(r), 7414(a), with respect to the Danversport Superfund Site, a former inks and paint products manufacturing facility...

21 CFR 872.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act). 872.9 Section 872.9 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES DENTAL DEVICES General...

21 CFR 872.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act). 872.9 Section 872.9 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES DENTAL DEVICES General...

21 CFR 866.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act). 866.9 Section 866.9 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY...

21 CFR 866.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act). 866.9 Section 866.9 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY...

21 CFR 866.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act). 866.9 Section 866.9 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY...

21 CFR 866.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act). 866.9 Section 866.9 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY...

2 CFR 176.190 - Award term-Wage rate requirements under Section 1606 of the Recovery Act.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Section 1606 of the Recovery Act. 176.190 Section 176.190 Grants and Agreements Office of Management and... FUNDS UNDER THE AMERICAN RECOVERY AND REINVESTMENT ACT OF 2009, PUBLIC LAW 111-5 Wage Rate Requirements Under Section 1606 of the American Recovery and Reinvestment Act of 2009 § 176.190 Award term—Wage rate...

2 CFR 176.190 - Award term-Wage rate requirements under Section 1606 of the Recovery Act.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Section 1606 of the Recovery Act. 176.190 Section 176.190 Grants and Agreements Office of Management and... FUNDS UNDER THE AMERICAN RECOVERY AND REINVESTMENT ACT OF 2009, PUBLIC LAW 111-5 Wage Rate Requirements Under Section 1606 of the American Recovery and Reinvestment Act of 2009 § 176.190 Award term—Wage rate...

40 CFR 52.1833 - Section 110(a)(2) infrastructure requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the 1997 and 2006 PM2.5 NAAQS: CAA section 110(a)(2)(A), (B), (C) with respect to minor NSR and PSD... PSD requirements for the 2006 PM2.5 NAAQS. [77 FR 57032, Sept. 17, 2012, as amended at 78 FR 45458...

Tribal Grants under Section 106 of the Clean Water Act

EPA Pesticide Factsheets

EPA provides technical assistance and funding under the Clean Water Act Section 106 program to assist tribes and intertribal consortia to understand, assess, and preserve water resources on their lands.

78 FR 36440 - Approval and Promulgation of Implementation Plans; Tennessee; 110(a)(1) and (2) Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-18

... Lead National Ambient Air Quality Standards AGENCY: Environmental Protection Agency (EPA). ACTION... the requirements of sections 110(a)(1) and (2) of the Clean Air Act (CAA or Act) for the 2008 Lead... that ensure the 2008 Lead NAAQS are implemented, enforced, and maintained in Tennessee. With the...

76 FR 4661 - Science Advisory Board Staff Office; Notification of a Public Meeting of the Clean Air Scientific...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

...: Background: Pursuant to the Federal Advisory Committee Act (FACA), Public Law 92-463 5 U.S.C., App. 2, notice... established under section 109(d)(2) of the Clean Air Act (CAA or Act) (42 U.S.C. 7409) as an independent... requisite protection of public health and welfare, respectively (75 FR 2938-3052; January 19, 2010). Since...

17 CFR 170.10 - Proficiency examinations (sections 4p and 17(p) of the Act).

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Proficiency examinations (sections 4p and 17(p) of the Act). 170.10 Section 170.10 Commodity and Securities Exchanges COMMODITY... examinations (sections 4p and 17(p) of the Act). A futures association may prescribe different training...

17 CFR 170.10 - Proficiency examinations (sections 4p and 17(p) of the Act).

Code of Federal Regulations, 2013 CFR

2013-04-01

... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Proficiency examinations (sections 4p and 17(p) of the Act). 170.10 Section 170.10 Commodity and Securities Exchanges COMMODITY... examinations (sections 4p and 17(p) of the Act). A futures association may prescribe different training...

17 CFR 170.10 - Proficiency examinations (sections 4p and 17(p) of the Act).

Code of Federal Regulations, 2012 CFR

2012-04-01

... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Proficiency examinations (sections 4p and 17(p) of the Act). 170.10 Section 170.10 Commodity and Securities Exchanges COMMODITY... examinations (sections 4p and 17(p) of the Act). A futures association may prescribe different training...

17 CFR 170.10 - Proficiency examinations (sections 4p and 17(p) of the Act).

Code of Federal Regulations, 2014 CFR

2014-04-01

... 17 Commodity and Securities Exchanges 2 2014-04-01 2014-04-01 false Proficiency examinations (sections 4p and 17(p) of the Act). 170.10 Section 170.10 Commodity and Securities Exchanges COMMODITY... Proficiency examinations (sections 4p and 17(p) of the Act). A futures association may prescribe different...

17 CFR 170.10 - Proficiency examinations (sections 4p and 17(p) of the Act).

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Proficiency examinations (sections 4p and 17(p) of the Act). 170.10 Section 170.10 Commodity and Securities Exchanges COMMODITY... examinations (sections 4p and 17(p) of the Act). A futures association may prescribe different training...

26 CFR 302.1 - Statutory provisions and Executive order; section 212 of the International Claims Settlement Act...

Code of Federal Regulations, 2010 CFR

2010-04-01

... ADMINISTRATION TAXES UNDER THE INTERNATIONAL CLAIMS SETTLEMENT ACT, AS AMENDED AUGUST 9, 1955 § 302.1 Statutory provisions and Executive order; section 212 of the International Claims Settlement Act, and Executive Order...; section 212 of the International Claims Settlement Act, and Executive Order 10644. 302.1 Section 302.1...

77 FR 31496 - Approval and Promulgation of Air Quality Implementation Plans; Massachusetts and New Hampshire...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-29

...(b)(2)(A) of the Clean Air Act (CAA), that the Boston-Lawrence-Worcester (Eastern Massachusetts...) proposing its determination under section 181(b)(2) that the Boston-Lawrence- Worcester (Eastern... section 181(b)(2)(A), that the Boston-Lawrence- Worcester (Eastern Massachusetts) moderate 1997 eight-hour...

76 FR 49698 - Covered Securities Pursuant to Section 18 of the Securities Act of 1933

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-11

... [Release No. 33-9251; File No. S7-31-11] RIN 3235-AL20 Covered Securities Pursuant to Section 18 of the... under Section 18 of the Securities Act of 1933 (``Securities Act''), as amended, to designate certain securities on BATS Exchange, Inc. (``BATS'' or ``Exchange'') as covered securities for purposes of Section 18...

75 FR 19335 - Premium Review Process; Request for Comments Regarding Section 2794 of the Public Health Service Act

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-14

... Review Process; Request for Comments Regarding Section 2794 of the Public Health Service Act AGENCY..., which added Section 2794 to the Public Health Service Act (the PHS Act). Section 2794 of the PHS Act... Department of Health and Human Services (HHS) invites public comments in advance of future rulemaking. DATES...

77 FR 21913 - Approval and Promulgation of State Implementation Plans; Hawaii; Infrastructure Requirements for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-12

... Promulgation of State Implementation Plans; Hawaii; Infrastructure Requirements for the 1997 8-Hour Ozone and... requirements of Section 110(a)(1) and (2) of the Clean Air Act (CAA) for the 1997 8-hour ozone national ambient...): Air quality modeling and submission of modeling data. Section 110(a)(2)(L): Permitting fees. Section...

Clean Air Act Section 112(r) Inspection Guidance Distribution Memorandum

EPA Pesticide Factsheets

This memorandum issues and makes immediately effective the document, Guidance for Conducting Risk Management Program Inspections under Clean Air Act Section 112(r), which supersedes the 1999 document on auditing risk management plans/programs.

29 CFR 1990.151 - Model standard pursuant to section 6(b) of the Act.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 9 2011-07-01 2011-07-01 false Model standard pursuant to section 6(b) of the Act. 1990... OCCUPATIONAL CARCINOGENS Model Standards § 1990.151 Model standard pursuant to section 6(b) of the Act... an action level as a limitation on requirements for periodic monitoring (para. (e)(3)), medical...

Combined effect of loss of the caa3 oxidase and Crp regulation drives Shewanella to thrive in redox-stratified environments.

PubMed

Zhou, Guangqi; Yin, Jianhua; Chen, Haijiang; Hua, Yijie; Sun, Linlin; Gao, Haichun

2013-09-01

Shewanella species are a group of facultative Gram-negative microorganisms with remarkable respiration abilities that allow the use of a diverse array of terminal electron acceptors (EA). Like most bacteria, S. oneidensis possesses multiple terminal oxidases, including two heme-copper oxidases (caa3- and cbb3-type) and a bd-type quinol oxidase. As aerobic respiration is energetically favored, mechanisms underlying the fact that these microorganisms thrive in redox-stratified environments remain vastly unexplored. In this work, we discovered that the cbb3-type oxidase is the predominant system for respiration of oxygen (O2), especially when O2 is abundant. Under microaerobic conditions, the bd-type quinol oxidase has a significant role in addition to the cbb3-type oxidase. In contrast, multiple lines of evidence suggest that under test conditions the caa3-type oxidase, an analog to the mitochondrial enzyme, has no physiological significance, likely because of its extremely low expression. In addition, expression of both cbb3- and bd-type oxidases is under direct control of Crp (cAMP receptor protein) but not the well-established redox regulator Fnr (fumarate nitrate regulator) of canonical systems typified in Escherichia coli. These data, collectively, suggest that adaptation of S. oneidensis to redox-stratified environments is likely due to functional loss of the caa3-type oxidase and switch of the regulatory system for respiration.

ATXN2 with intermediate-length CAG/CAA repeats does not seem to be a risk factor in hereditary spastic paraplegia.

PubMed

Nielsen, Troels Tolstrup; Svenstrup, Kirsten; Budtz-Jørgensen, Esben; Eiberg, Hans; Hasholt, Lis; Nielsen, Jørgen E

2012-10-15

Hereditary spastic paraplegia (HSP) confines a group of heterogeneous neurodegenerative disorders characterized by progressive spasticity and lower limb weakness. Age of onset is highly variable even in familial cases with known mutations suggesting that the disease is modulated by other yet unknown parameters. Although progressive gait disturbances, lower limb spasticity and extensor plantar responses are hallmarks of HSP these characteristics are also found in other neurodegenerative disorders, e.g. amytrophic lateral sclerosis (ALS). HSP has been linked to ALS and frontotemporal degeneration with motor neuron disease (FTD-MND), since TDP-43 positive inclusions have recently been found in an HSP subtype, and TDP-43 are found in abundance in pathological inclusions of both ALS and FTD-MND. Furthermore, ataxin-2 (encoded by the gene ATXN2), a polyglutamine containing protein elongated in spinocerebellar ataxia type 2, has been shown to be a modulator of TDP-43 induced toxicity in ALS animal and cell models. Finally, it has been shown that ATXN2 with non-pathogenic intermediate-length CAG/CAA repeat elongations (encoding the polyglutamine tract) is a genetic risk factor of ALS. Considering the similarities in the disease phenotype and the neuropathological link between ALS and HSP we hypothesized that intermediate-length CAG/CAA repeats in ATXN2 could be a modulator of HSP. We show that in a cohort of 181 HSP patients 4.9 % of the patients had intermediate-length CAG/CAA repeats in ATXN2 which was not significantly different from the frequencies in a Danish control cohort or in American and European control populations. However, the mean age of onset was significantly lower in HSP patients with intermediate-length CAG/CAA repeats in ATXN2 compared to patients with normal length repeats. Based on these results we conclude that ATXN2 is most likely not a risk factor of HSP, whereas it might serve as a modulator of age of onset. Copyright © 2012 Elsevier B.V. All

76 FR 19292 - Approval and Promulgation of Implementation Plans; Oregon; Interstate Transport of Pollution...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-07

...EPA is proposing to approve a portion of the State Implementation Plan (SIP) revision submitted by the State of Oregon for the purpose of addressing the interstate transport provisions of Clean Air Act (CAA) section 110(a)(2)(D)(i)(I) for the 1997 8-hour ozone National Ambient Air Quality Standards (NAAQS or standards) and the 1997 fine particulate matter (PM2.5) NAAQS. Section 110(a)(2)(D)(i) of the CAA requires that each State have adequate provisions to prohibit air emissions from adversely affecting air quality in other States through interstate transport. EPA is proposing to approve Oregon's SIP revision for the 1997 8-hour ozone and 1997 PM2.5 NAAQS as meeting the requirements of CAA section 110(a)(2)(D)(i)(I) to prohibit emissions that will contribute significantly to nonattainment of the these standards in any other State and to prohibit emissions that will interfere with maintenance of these standards by any other State.

29 CFR 780.724 - Work exempt under another section of the Act.

Code of Federal Regulations, 2014 CFR

2014-07-01

... STANDARDS ACT Employment by Small Country Elevators Within Area of Production; Exemption From Overtime Pay... is exempt only from the overtime pay provisions under another section, the employee is exempt that..., attention is directed to another exemption in the Act which relates to work in grain elevators, which may...

29 CFR 780.724 - Work exempt under another section of the Act.

Code of Federal Regulations, 2012 CFR

2012-07-01

... STANDARDS ACT Employment by Small Country Elevators Within Area of Production; Exemption From Overtime Pay... is exempt only from the overtime pay provisions under another section, the employee is exempt that..., attention is directed to another exemption in the Act which relates to work in grain elevators, which may...

29 CFR 780.724 - Work exempt under another section of the Act.

Code of Federal Regulations, 2013 CFR

2013-07-01

... STANDARDS ACT Employment by Small Country Elevators Within Area of Production; Exemption From Overtime Pay... is exempt only from the overtime pay provisions under another section, the employee is exempt that..., attention is directed to another exemption in the Act which relates to work in grain elevators, which may...

29 CFR 780.724 - Work exempt under another section of the Act.

Code of Federal Regulations, 2011 CFR

2011-07-01

... STANDARDS ACT Employment by Small Country Elevators Within Area of Production; Exemption From Overtime Pay... is exempt only from the overtime pay provisions under another section, the employee is exempt that..., attention is directed to another exemption in the Act which relates to work in grain elevators, which may...

29 CFR 780.724 - Work exempt under another section of the Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

... STANDARDS ACT Employment by Small Country Elevators Within Area of Production; Exemption From Overtime Pay... is exempt only from the overtime pay provisions under another section, the employee is exempt that..., attention is directed to another exemption in the Act which relates to work in grain elevators, which may...

75 FR 19297 - Medical Loss Ratios; Request for Comments Regarding Section 2718 of the Public Health Service Act

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-14

...This document is a request for comments regarding Section 2718 of the Public Health Service Act (PHS Act), which was added by Sections 1001 and 10101 of the Patient Protection and Affordable Care Act (PPACA), Public Law 111-148, enacted on March 23, 2010. Section 2718 of the PHS Act, among other provisions, requires health insurance issuers offering individual or group coverage to submit annual reports to the Secretary on the percentages of premiums that the coverage spends on reimbursement for clinical services and activities that improve health care quality, and to provide rebates to enrollees if this spending does not meet minimum standards for a given plan year. Section 1562 of PPACA also added section 715 of the Employee Retirement Income Security Act of 1974 (ERISA) and section 9815 of the Internal Revenue Code of 1986 (the Code). These two sections effectively incorporate by reference section 2718 and other amendments to title XXVII of the PHS Act. The Departments of Health and Human Services (HHS), Labor, and the Treasury (collectively, the Departments) invite public comments in advance of future rulemaking.

48 CFR 970.2670 - Implementation of Section 3021 of the Energy Policy Act of 1992.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 3021 of the Energy Policy Act of 1992. 970.2670 Section 970.2670 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Other Socioeconomic Programs 970.2670 Implementation of Section 3021 of the Energy Policy Act of 1992. ...

48 CFR 970.2670 - Implementation of Section 3021 of the Energy Policy Act of 1992.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 3021 of the Energy Policy Act of 1992. 970.2670 Section 970.2670 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Other Socioeconomic Programs 970.2670 Implementation of Section 3021 of the Energy Policy Act of 1992. ...

48 CFR 970.2670 - Implementation of Section 3021 of the Energy Policy Act of 1992.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 3021 of the Energy Policy Act of 1992. 970.2670 Section 970.2670 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Other Socioeconomic Programs 970.2670 Implementation of Section 3021 of the Energy Policy Act of 1992. ...

48 CFR 970.2670 - Implementation of Section 3021 of the Energy Policy Act of 1992.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 3021 of the Energy Policy Act of 1992. 970.2670 Section 970.2670 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Other Socioeconomic Programs 970.2670 Implementation of Section 3021 of the Energy Policy Act of 1992. ...

48 CFR 970.2670 - Implementation of Section 3021 of the Energy Policy Act of 1992.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 3021 of the Energy Policy Act of 1992. 970.2670 Section 970.2670 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Other Socioeconomic Programs 970.2670 Implementation of Section 3021 of the Energy Policy Act of 1992. ...

77 FR 43342 - Notice Regarding Section 340B of the Public Health Service Act Registration Period

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-24

... Regarding Section 340B of the Public Health Service Act Registration Period AGENCY: Department of Health and... INFORMATION: I. Background Section 340B(a)(4) of the Public Health Service Act (PHS) Act (42 U.S.C. 256b... of these date parameters listed above except when the Secretary has declared a Public Health...

Title III List of Lists -- Raw Data Set

EPA Pesticide Factsheets

This list was prepared to help firms handling chemicals determine whether they need to submit reports under sections 302, 304, or 313 of the Emergency Planning and Community Right-to-Know Act of 1986 (EPCRA) and, for a specific chemical, what reports may need to be submitted. It will also help firms determine whether they will be subject to accident prevention regulations under Clean Air Act (CAA) section 112(r).

Title III List of Lists -- Data Tool

EPA Pesticide Factsheets

This list was prepared to help firms handling chemicals determine whether they need to submit reports under sections 302, 304, or 313 of the Emergency Planning and Community Right-to-Know Act of 1986 (EPCRA) and, for a specific chemical, what reports may need to be submitted. It will also help firms determine whether they will be subject to accident prevention regulations under Clean Air Act (CAA) section 112(r).

Time-resolved single-turnover of caa(3) oxidase from Thermus thermophilus. Fifth electron of the fully reduced enzyme converts O(H) into E(H) state.

PubMed

Siletsky, Sergey A; Belevich, Ilya; Belevich, Nikolai P; Soulimane, Tewfik; Verkhovsky, Michael I

2011-09-01

The oxidative part of the catalytic cycle of the caa(3)-type cytochrome c oxidase from Thermus thermophilus was followed by time-resolved optical spectroscopy. Rate constants, chemical nature and the spectral properties of the catalytic cycle intermediates (Compounds A, P, F) reproduce generally the features typical for the aa(3)-type oxidases with some distinctive peculiarities caused by the presence of an additional 5-th redox-center-a heme center of the covalently bound cytochrome c. Compound A was formed with significantly smaller yield compared to aa(3) oxidases in general and to ba(3) oxidase from the same organism. Two electrons, equilibrated between three input redox-centers: heme a, Cu(A) and heme c are transferred in a single transition to the binuclear center during reduction of the compound F, converting the binuclear center through the highly reactive O(H) state into the final product of the reaction-E(H) (one-electron reduced) state of the catalytic site. In contrast to previous works on the caa(3)-type enzymes, we concluded that the finally produced E(H) state of caa(3) oxidase is characterized by the localization of the fifth electron in the binuclear center, similar to the O(H)→E(H) transition of the aa(3)-type oxidases. So, the fully-reduced caa(3) oxidase is competent in rapid electron transfer from the input redox-centers into the catalytic heme-copper site. 2011 Elsevier B.V. All rights reserved.

75 FR 2539 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-15

... Analysis Information Under Section 112(r)(7)(H) of the Clean Air Act (CAA) (Renewal); EPA ICR No. 1981.04... . Title: Distribution of Offsite Consequence Analysis Information under Section 112(r)(7)(H) of the Clean... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OAR-2003-0073; FRL-9103-6] Agency Information Collection...

Congressional Reporting for Section 404 of the Clean Water Act

EPA Pesticide Factsheets

In accordance with EPA's fiscal years 2014 and 2015 appropriations, the Agency is required to submit regular reports to Congress regarding review of public notices issued by the U.S. Army Corps of Engineers for proposed Clean Water Act Section 404 standard

19 CFR 162.75 - Seizures limited under section 592, Tariff Act of 1930, as amended.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Seizures limited under section 592, Tariff Act of... OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) INSPECTION, SEARCH, AND SEIZURE Special Procedures for Certain Violations § 162.75 Seizures limited under section 592, Tariff Act of 1930, as amended...

45 CFR 201.14 - Reconsideration under section 1116(d) of the Act.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 2 2012-10-01 2012-10-01 false Reconsideration under section 1116(d) of the Act. 201.14 Section 201.14 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN...

45 CFR 201.14 - Reconsideration under section 1116(d) of the Act.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 2 2013-10-01 2012-10-01 true Reconsideration under section 1116(d) of the Act. 201.14 Section 201.14 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN...

45 CFR 201.14 - Reconsideration under section 1116(d) of the Act.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 2 2014-10-01 2012-10-01 true Reconsideration under section 1116(d) of the Act. 201.14 Section 201.14 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN...

Importance of low-range CAG expansion and CAA interruption in SCA2 Parkinsonism.

PubMed

Kim, Jong-Min; Hong, Susie; Kim, Gyoung Pyoung; Choi, Yoon Jae; Kim, Yu Kyeong; Park, Sung Sup; Kim, Sang Eun; Jeon, Beom S

2007-10-01

To examine the presence of an ATXN2 mutation in patients with parkinsonism in the Korean population and to find the difference in the ATXN2 mutation between ataxic and parkinsonian phenotypes. Survey. Seoul National University Hospital (a referral center). Patients Patients with Parkinson disease (PD) (n = 468) and the Parkinson variant of multiple system atrophy (MSA-P) (n = 135) who were seen at our Department of Neurology during the past 3 years. CAG expansion in spinocerebellar ataxia type 2 (SCA2) alleles was assessed by polymerase chain reaction amplification and fragment analysis, and its size and interruption were verified by cloning and sequencing. SCA2 was tested also in the family members of the probands. Striatal dopamine transporter (DAT) and D(2) receptor status were evaluated in the probands and their SCA2-positive family members using iodine I 123 [(123)I]-radiolabeled fluoropropyl (FP) 2-carbomethoxy-3-(4-iodophenyl) tropane (CIT) with single-photon emission computed tomography (SPECT) and carbon C 11 [(11)C]-radiolabeled raclopride positron emission tomography (PET). We found 3 patients with apparently sporadic disease with expanded CAG repeats in the ATXN2 locus. Two patients had a PD phenotype. The third patient showed an MSA-P phenotype. The CAG repeats in the ATXN2 locus of the patients were 35/22, 34/22, and 32/22, respectively (range in normal population, 19-27). The size of repeats was lower than the CAG repeats (38-51) in ataxic SCA2 in our population. The sequence of expanded CAG repeats was interrupted by CAA as (CAG)(n)(CAA)(CAG)(8) in all the patients. DNA analyses in 2 families showed 2 asymptomatic carriers in each family. In the patient with the PD phenotype, striatal DAT loss was more severe in the putamen than the caudate, and [(11)C]raclopride PET showed an increased relative putamen-caudate binding ratio. The patient with the MSA-P phenotype had severe DAT loss throughout the striatum. Two of 3 asymptomatic carriers had striatal

75 FR 3468 - Revised Jurisdictional Thresholds For Section 7A of the Clayton Act

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-21

... revised thresholds for the Hart-Scott-Rodino Antitrust Improvements Act of 1976 required by the 2000... Hart-Scott-Rodino Antitrust Improvements Act of 1976, Pub. L. 94-435, 90 Stat. 1390 (``the Act... product, in accordance with Section 8(a)(5). The new thresholds, which take effect 30 days after...

Memorandum of Agreement: Exemptions Under Section 404(F) of the Clean Water Act

EPA Pesticide Factsheets

Memorandum of Agreement between the Department of the Army and the Environmental Protection Agency Concerning the Determination of the Section 404 Program and the Application of the Exemptions Under Section 404(F) of the Clean Water Act

Overview of SNAP

EPA Pesticide Factsheets

Section 612(c) of the Clean Air Act (CAA) requires the Agency to publish a list of acceptable and unacceptable substitutes for ozone-depleting substances (ODS). The SNAP program does not require that substitutes be risk- free to be found acceptable.

Proposed Cross-State Air Pollution Update Rule - Status of the 110(a)(2)(D)(i)(I) SIPs TSD

EPA Pesticide Factsheets

The status of each Clean Air Act (CAA) section 110(a)(2)(D)(i)(I) SIPs for the 2008 ozone NAAQS for the eastern states and the District of Columbia that are the focus of the proposed CSAPR update Rule

Test Report for DCU D603 Vent at the ExxonMobil Baytown Refinery Performed July 14 through July 17, 2011

EPA Pesticide Factsheets

ExxonMobil owns and operates a petroleum refinery in Baytown, Texas that is subject to the U.S. Clean Air Act (CAA) Sections 111 and 112. This report presents the results of the test program conducted July 14 through 17, 2011.

16 CFR 1610.39 - Shipments under section 11(c) of the Act.

Code of Federal Regulations, 2014 CFR

2014-01-01

... duly authorized agent so as to render them not so highly flammable under the provisions of section 4 of.... 1610.39 Section 1610.39 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT... processing to render them not so highly flammable as to be dangerous when worn by individuals, shall contain...

16 CFR 1610.39 - Shipments under section 11(c) of the Act.

Code of Federal Regulations, 2010 CFR

2010-01-01

... duly authorized agent so as to render them not so highly flammable under the provisions of section 4 of.... 1610.39 Section 1610.39 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT... processing to render them not so highly flammable as to be dangerous when worn by individuals, shall contain...

16 CFR 1610.39 - Shipments under section 11(c) of the Act.

Code of Federal Regulations, 2011 CFR

2011-01-01

... duly authorized agent so as to render them not so highly flammable under the provisions of section 4 of.... 1610.39 Section 1610.39 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT... processing to render them not so highly flammable as to be dangerous when worn by individuals, shall contain...

16 CFR 1610.39 - Shipments under section 11(c) of the Act.

Code of Federal Regulations, 2012 CFR

2012-01-01

... duly authorized agent so as to render them not so highly flammable under the provisions of section 4 of.... 1610.39 Section 1610.39 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT... processing to render them not so highly flammable as to be dangerous when worn by individuals, shall contain...

40 CFR 90.903 - Exclusions, application of section 216 (10) and (11) of the Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

... section 216(10) of the Act, an internal combustion engine (including the fuel system) that is not used in a motor vehicle is deemed a nonroad engine, if it meets the definition in subpart A of this part. For the purpose of determining the applicability of section 216(11) of the Act, a vehicle powered by a...

40 CFR 90.903 - Exclusions, application of section 216 (10) and (11) of the Act.

Code of Federal Regulations, 2011 CFR

2011-07-01

... section 216(10) of the Act, an internal combustion engine (including the fuel system) that is not used in a motor vehicle is deemed a nonroad engine, if it meets the definition in subpart A of this part. For the purpose of determining the applicability of section 216(11) of the Act, a vehicle powered by a...

26 CFR 2.1 - Statutory provisions; sections 511 and 905, Merchant Marine Act, 1936, and related statutes.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (e) (49 Stat. 2016), amended by sec. 39 (a) and (b), Act of June 23, 1938 (Pub. L. 705, 75th Cong..., Merchant Marine Act, 1936, and related statutes. 2.1 Section 2.1 Internal Revenue INTERNAL REVENUE SERVICE... Statutory provisions; sections 511 and 905, Merchant Marine Act, 1936, and related statutes. Sec. 511...

Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA).

PubMed

Burwinkel, Michael; Lutzenberger, Manuel; Heppner, Frank L; Schulz-Schaeffer, Walter; Baier, Michael

2018-03-05

Seeding and spread of beta-amyloid (Aβ) pathologies have been considered to be based on prion-like mechanisms. However, limited transmissibility of Aβ seeding activity upon peripheral exposure would represent a key difference to prions, not only in terms of pathogenesis but also in terms of potential transmission of disease. We partially characterized the seeded Aβ amyloidosis after intracerebral injection of various brain homogenates in APP/PS1 mice. One particularly seed-laden homogenate was selected to investigate the development of Aβ pathologies after intravenous exposure. We report here that a single intravenous injection of an Alzheimer disease patient's-brain extract into APP/PS1 recipient mice led to cerebral amyloid angiopathy within 180 days post injection. Thus, vascular proteinopathies such as CAA are transmissible in mice via the intravenous route of peripheral exposure.

Possible reduced penetrance of expansion of 44 to 47 CAG/CAA repeats in the TATA-binding protein gene in spinocerebellar ataxia type 17.

PubMed

Oda, Masaya; Maruyama, Hirofumi; Komure, Osamu; Morino, Hiroyuki; Terasawa, Hideo; Izumi, Yuishin; Imamura, Tohru; Yasuda, Minoru; Ichikawa, Keiji; Ogawa, Masafumi; Matsumoto, Masayasu; Kawakami, Hideshi

2004-02-01

Spinocerebellar ataxia type 17 (SCA17) is an autosomal dominant cerebellar ataxia caused by expansion of CAG/CAA trinucleotide repeats in the TATA-binding protein (TBP) gene. Because the number of triplets in patients with SCA17 in previous studies ranged from 43 to 63, the normal number of trinucleotide units has been considered to be 42 or less. However, some healthy subjects in SCA17 pedigrees carry alleles with the same number of expanded repeats as patients with SCA17. To investigate the minimum number of CAG/CAA repeats in the TBP gene that causes SCA17. We amplified the region of the TBP gene containing the CAG/CAA repeat by means of polymerase chain reaction and performed fragment and sequence analyses. The subjects included 734 patients with SCA (480 patients with sporadic SCA and 254 patients with familial SCA) without CAG repeat expansions at the SCA1, SCA2, Machado-Joseph disease, SCA6, SCA7, or dentatorubral-pallidolluysian atrophy loci, with 162 healthy subjects, 216 patients with Parkinson disease, and 195 with Alzheimer disease as control subjects. Eight patients with SCA possessed an allele with more than 43 CAG/CAA repeats. Among the non-SCA groups, alleles with 43 to 45 repeats were seen in 3 healthy subjects and 2 with Parkinson disease. In 1 SCA pedigree, a patient with possible SCA17 and her healthy sister had alleles with 45 repeats. A 34-year-old man carrying alleles with 47 and 44 repeats (47/44) had developed progressive cerebellar ataxia and myoclonus at 25 years of age, and he exhibited dementia and pyramidal signs. He was the only affected person in his pedigree, although his father and mother carried alleles with mildly expanded repeats (44/36 and 47/36, respectively). In another pedigree, 1 patient carried a 43-repeat allele, whereas another patient had 2 normal alleles, indicating that the 43-repeat allele may not be pathologic in this family. We estimate that 44 CAG/CAA repeats is the minimum number required to cause SCA17. However

42 CFR 121.13 - Definition of Human Organ Under section 301 of the National Organ Transplant Act, as amended.

Code of Federal Regulations, 2010 CFR

2010-10-01

... National Organ Transplant Act, as amended. 121.13 Section 121.13 Public Health PUBLIC HEALTH SERVICE... NETWORK § 121.13 Definition of Human Organ Under section 301 of the National Organ Transplant Act, as amended. “Human organ,” as covered by section 301 of the National Organ Transplant Act, as amended, means...

42 CFR 121.13 - Definition of Human Organ Under section 301 of the National Organ Transplant Act, as amended.

Code of Federal Regulations, 2011 CFR

2011-10-01

... National Organ Transplant Act, as amended. 121.13 Section 121.13 Public Health PUBLIC HEALTH SERVICE... NETWORK § 121.13 Definition of Human Organ Under section 301 of the National Organ Transplant Act, as amended. “Human organ,” as covered by section 301 of the National Organ Transplant Act, as amended, means...

42 CFR 121.13 - Definition of Human Organ Under section 301 of the National Organ Transplant Act, as amended.

Code of Federal Regulations, 2012 CFR

2012-10-01

... National Organ Transplant Act, as amended. 121.13 Section 121.13 Public Health PUBLIC HEALTH SERVICE... NETWORK § 121.13 Definition of Human Organ Under section 301 of the National Organ Transplant Act, as amended. “Human organ,” as covered by section 301 of the National Organ Transplant Act, as amended, means...

76 FR 28661 - Interim Final Determination To Defer Sanctions, Sacramento Metro 1-Hour Ozone Nonattainment Area...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-18

... Determination To Defer Sanctions, Sacramento Metro 1-Hour Ozone Nonattainment Area, California AGENCY... Act (CAA) Section 185 fee program (Termination Determination) for the Sacramento Metro 1- hour Ozone nonattainment area (Sacramento Metro Area) to satisfy anti- backsliding requirements for the 1-hour Ozone...

17 CFR 240.12h-1 - Exemptions from registration under section 12(g) of the Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exemptions from registration under section 12(g) of the Act. 240.12h-1 Section 240.12h-1 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, SECURITIES EXCHANGE ACT OF 1934...

22 CFR 1104.11 - Relationship to section 106 of the National Historic Preservation Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Relationship to section 106 of the National Historic Preservation Act. 1104.11 Section 1104.11 Foreign Relations INTERNATIONAL BOUNDARY AND WATER COMMISSION, UNITED STATES AND MEXICO, UNITED STATES SECTION PROTECTION OF ARCHAEOLOGICAL RESOURCES § 1104.11...

22 CFR 1104.11 - Relationship to section 106 of the National Historic Preservation Act.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Relationship to section 106 of the National Historic Preservation Act. 1104.11 Section 1104.11 Foreign Relations INTERNATIONAL BOUNDARY AND WATER COMMISSION, UNITED STATES AND MEXICO, UNITED STATES SECTION PROTECTION OF ARCHAEOLOGICAL RESOURCES § 1104.11...

3 CFR - Delegation of Certain Functions Under Section 1265 of the National Defense Authorization Act for...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 3 The President 1 2011-01-01 2011-01-01 false Delegation of Certain Functions Under Section 1265 of the National Defense Authorization Act for Fiscal Year 2010 Presidential Documents Other Presidential Documents Memorandum of April 20, 2010 Delegation of Certain Functions Under Section 1265 of the National Defense Authorization Act for Fiscal...

8 CFR 1245.8 - Adjustment of status as a special immigrant under section 101(a)(27)(K) of the Act.

Code of Federal Regulations, 2014 CFR

2014-01-01

... under section 101(a)(27)(K) of the Act. 1245.8 Section 1245.8 Aliens and Nationality EXECUTIVE OFFICE... section 101(a)(27)(K) of the Act. (a) Application. Each person applying for adjustment of status as a special immigrant under section 101(a)(27)(K) of the Act must file a Form I-485, Application to Register...

29 CFR 1977.3 - General requirements of section 11(c) of the Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false General requirements of section 11(c) of the Act. 1977.3 Section 1977.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) DISCRIMINATION AGAINST EMPLOYEES EXERCISING RIGHTS UNDER THE...

76 FR 59090 - Approval and Promulgation of Implementation Plans; Oregon: New Source Review/Prevention of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-23

...EPA is proposing to approve a portion of the State Implementation Plan (SIP) revision submitted by the State of Oregon for the purpose of addressing the third element of the interstate transport provisions of Clean Air Act (CAA or the Act) section 110(a)(2)(D)(i)(II) for the 1997 8-hour ozone National Ambient Air Quality Standards (NAAQS or standards) and the 1997 and 2006 fine particulate matter (PM2.5) NAAQS. The third element of CAA section 110(a)(2)(D)(i)(II) requires that a State not interfere with any other State's required measures to prevent significant deterioration (PSD) of its air quality. EPA is also proposing to approve numerous revisions to the Oregon SIP that were submitted to EPA by the State of Oregon on October 8, 2008; October 10, 2008; March 17, 2009; June 23, 2010; December 22, 2010 and May 5, 2011. The revisions include updating Oregon's new source review (NSR) rules to be consistent with current Federal regulations and streamlining Oregon's air quality rules by clarifying requirements, removing duplicative rules, and correcting errors. The revisions were submitted in accordance with the requirements of section 110 and part D of the Act).

17 CFR 240.12h-1 - Exemptions from registration under section 12(g) of the Act.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Exemptions from registration... optionholder until the issuer becomes subject to the reporting requirements of section 13 or 15(d) of the Act... to the reporting requirements of section 13 or 15(d) of the Act or is no longer relying on the...

29 CFR 102.95 - Priority of cases pursuant to section 10(l) and (m) of the Act.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 2 2011-07-01 2011-07-01 false Priority of cases pursuant to section 10(l) and (m) of the... AND REGULATIONS, SERIES 8 Procedure in Cases Under Section 10(j), (l), and (m) of the Act § 102.95 Priority of cases pursuant to section 10(l) and (m) of the Act. (a) Whenever a charge is filed alleging the...

29 CFR 102.95 - Priority of cases pursuant to section 10(l) and (m) of the Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 2 2010-07-01 2010-07-01 false Priority of cases pursuant to section 10(l) and (m) of the... AND REGULATIONS, SERIES 8 Procedure in Cases Under Section 10(j), (l), and (m) of the Act § 102.95 Priority of cases pursuant to section 10(l) and (m) of the Act. (a) Whenever a charge is filed alleging the...

RCRA/UST, superfund, and EPCRA hotline training module. Introduction to accidental release prevention program (CAA section 112(r); 40 CFR part 68). Updated as of November 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-03-01

The module explains the purpose of Section 112(r) of the Clean Air Act and how it relates to the goals and requirements of the Emergency Planning and Community Right-to-know Act (EPCRA). It describes the promulgation of the list of regulated substances. It discusses the risk management planning requirements and explains how the risk management rule is being promulgated. It identifies the presidential review and describes the similarity of the risk management program to the occupational health and safety administration`s process safety management standard.

77 FR 75384 - Approval and Promulgation of Air Quality Implementation Plans; Indiana; Delaware County (Muncie...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-20

..., state and Federal agencies in determining whether transportation activities conform to the SIP as... reflected in MOBILE6.2. Under section 176(c) of the Clean Air Act (CAA), transportation plans, Transportation Improvement Programs (TIPs), and transportation projects must ``conform'' to (i.e., be consistent...

Memorandum: Status of 110(a)(2)(D)(i)(I) SIPs for the 2008 Ozone NAAQS

EPA Pesticide Factsheets

This document describes the status of each Clean Air Act (CAA) section 110(a)(2)(D)(i)(I) state implementation plan (SIP) for the 2008 ozone NAAQS for the eastern states and the District of Columbia that are the focus of the final rule.

47 CFR 51.809 - Availability of agreements to other telecommunications carriers under section 252(i) of the Act.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 3 2014-10-01 2014-10-01 false Availability of agreements to other telecommunications carriers under section 252(i) of the Act. 51.809 Section 51.809 Telecommunication FEDERAL... Implementation of Section 252 of the Act § 51.809 Availability of agreements to other telecommunications carriers...

47 CFR 51.809 - Availability of agreements to other telecommunications carriers under section 252(i) of the Act.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 3 2013-10-01 2013-10-01 false Availability of agreements to other telecommunications carriers under section 252(i) of the Act. 51.809 Section 51.809 Telecommunication FEDERAL... Implementation of Section 252 of the Act § 51.809 Availability of agreements to other telecommunications carriers...

47 CFR 51.809 - Availability of agreements to other telecommunications carriers under section 252(i) of the Act.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 3 2012-10-01 2012-10-01 false Availability of agreements to other telecommunications carriers under section 252(i) of the Act. 51.809 Section 51.809 Telecommunication FEDERAL... Implementation of Section 252 of the Act § 51.809 Availability of agreements to other telecommunications carriers...

47 CFR 51.809 - Availability of agreements to other telecommunications carriers under section 252(i) of the Act.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Availability of agreements to other telecommunications carriers under section 252(i) of the Act. 51.809 Section 51.809 Telecommunication FEDERAL... Implementation of Section 252 of the Act § 51.809 Availability of agreements to other telecommunications carriers...

47 CFR 51.809 - Availability of agreements to other telecommunications carriers under section 252(i) of the Act.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 3 2011-10-01 2011-10-01 false Availability of agreements to other telecommunications carriers under section 252(i) of the Act. 51.809 Section 51.809 Telecommunication FEDERAL... Implementation of Section 252 of the Act § 51.809 Availability of agreements to other telecommunications carriers...

Validation of High-Fidelity CFD/CAA Framework for Launch Vehicle Acoustic Environment Simulation against Scale Model Test Data

NASA Technical Reports Server (NTRS)

Liever, Peter A.; West, Jeffrey S.; Harris, Robert E.

2016-01-01

A hybrid Computational Fluid Dynamics and Computational Aero-Acoustics (CFD/CAA) modeling framework has been developed for launch vehicle liftoff acoustic environment predictions. The framework couples the existing highly-scalable NASA production CFD code, Loci/CHEM, with a high-order accurate Discontinuous Galerkin solver developed in the same production framework, Loci/THRUST, to accurately resolve and propagate acoustic physics across the entire launch environment. Time-accurate, Hybrid RANS/LES CFD modeling is applied for predicting the acoustic generation physics at the plume source, and a high-order accurate unstructured mesh Discontinuous Galerkin (DG) method is employed to propagate acoustic waves away from the source across large distances using high-order accurate schemes. The DG solver is capable of solving 2nd, 3rd, and 4th order Euler solutions for non-linear, conservative acoustic field propagation. Initial application testing and validation has been carried out against high resolution acoustic data from the Ares Scale Model Acoustic Test (ASMAT) series to evaluate the capabilities and production readiness of the CFD/CAA system to resolve the observed spectrum of acoustic frequency content. This paper presents results from this validation and outlines efforts to mature and improve the computational simulation framework.

Validation of High-Fidelity CFD/CAA Framework for Launch Vehicle Acoustic Environment Simulation against Scale Model Test Data

NASA Technical Reports Server (NTRS)

Liever, Peter A.; West, Jeffrey S.

2016-01-01

A hybrid Computational Fluid Dynamics and Computational Aero-Acoustics (CFD/CAA) modeling framework has been developed for launch vehicle liftoff acoustic environment predictions. The framework couples the existing highly-scalable NASA production CFD code, Loci/CHEM, with a high-order accurate discontinuous Galerkin solver developed in the same production framework, Loci/THRUST, to accurately resolve and propagate acoustic physics across the entire launch environment. Time-accurate, Hybrid RANS/LES CFD modeling is applied for predicting the acoustic generation physics at the plume source, and a high-order accurate unstructured discontinuous Galerkin (DG) method is employed to propagate acoustic waves away from the source across large distances using high-order accurate schemes. The DG solver is capable of solving 2nd, 3rd, and 4th order Euler solutions for non-linear, conservative acoustic field propagation. Initial application testing and validation has been carried out against high resolution acoustic data from the Ares Scale Model Acoustic Test (ASMAT) series to evaluate the capabilities and production readiness of the CFD/CAA system to resolve the observed spectrum of acoustic frequency content. This paper presents results from this validation and outlines efforts to mature and improve the computational simulation framework.

77 FR 68768 - Electricity Market Transparency Provisions of Section 220 of the Federal Power Act; Notice of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-16

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. RM10-12-000] Electricity Market Transparency Provisions of Section 220 of the Federal Power Act; Notice of Technical Conference...., Washington, DC 20426. \\1\\ Electricity Market Transparency Provisions of Section 220 of the Federal Power Act...

76 FR 51118 - Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-17

... SMALL BUSINESS ADMINISTRATION [Emergence Capital Partners SBIC, L.P. License No. 09/79-0454] Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest... Act and Section 107.730, Financings which Constitute Conflicts of Interest of the Small Business...

75 FR 48880 - Approval and Promulgation of Gila River Indian Community's Tribal Implementation Plan

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-12

...The Environmental Protection Agency (EPA) proposes to approve the Gila River Indian Community's (GRIC or the Tribe) Tribal Implementation Plan (TIP) under the Clean Air Act (CAA) to regulate air pollution within the exterior boundaries of the Tribe's reservation. The proposed TIP is one of four CAA regulatory programs that comprise the Tribe's Air Quality Management Plan (AQMP). EPA approved the Tribe for treatment in the same manner as a State (Treatment as State or TAS) for purposes of administering the AQMP and other CAA authorities on October 21, 2009. In this action we propose to act only on those portions of the AQMP that constitute a TIP containing severable elements of an implementation plan under CAA section 110(a). The proposed TIP includes general and emergency authorities, ambient air quality standards, permitting requirements for minor sources of air pollution, enforcement authorities, procedures for administrative appeals and judicial review in Tribal court, requirements for area sources of fugitive dust and fugitive particulate matter, general prohibitory rules, and source category-specific emission limitations. The purpose of the proposed TIP is to implement, maintain, and enforce the National Ambient Air Quality Standards (NAAQS) in the GRIC reservation. The intended effect of today's proposed action is to make the GRIC TIP federally enforceable.

32 CFR 229.12 - Relationship to section 106 of the National Historic Preservation Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Relationship to section 106 of the National Historic Preservation Act. 229.12 Section 229.12 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROTECTION OF ARCHAEOLOGICAL RESOURCES: UNIFORM REGULATIONS § 229.12 Relationship to section...

16 CFR 1500.88 - Exemptions from lead limits under section 101 of the Consumer Product Safety Improvement Act for...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 101 of the Consumer Product Safety Improvement Act for certain electronic devices. 1500.88 Section... from lead limits under section 101 of the Consumer Product Safety Improvement Act for certain electronic devices. (a) The Consumer Product Safety Improvement Act (CPSIA) provides for specific lead limits...

76 FR 31263 - Approval and Promulgation of Implementation Plans; State of California; Interstate Transport of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-31

...EPA is proposing a limited approval and limited disapproval of a State Implementation Plan (``SIP'') revision submitted by the State of California on November 17, 2007, for the purpose of addressing the ``transport SIP'' provisions of Clean Air Act (``CAA'') section 110(a)(2)(D)(i) for the 1997 8-hour ozone National Ambient Air Quality Standards (NAAQS or standards) and the 1997 fine particulate matter (``PM2.5'') NAAQS. Section 110(a)(2)(D)(i) of the CAA requires that each SIP contain adequate provisions to prohibit emissions that adversely affect air quality in other States through interstate transport. EPA is proposing a limited approval and limited disapproval of California's SIP revision for the 1997 8-hour ozone and 1997 PM2.5 NAAQS with respect to the requirement in CAA section 110(a)(2)(D)(i)(II) that each SIP contain adequate measures prohibiting emissions of air pollutants in amounts which will interfere with other States' measures required under title I, part C of the CAA to prevent significant deterioration of air quality. Specifically, EPA is proposing to approve California's SIP revision with respect to those Districts in California that implement SIP-approved permit programs meeting the approval criteria under CAA section 110(a)(2)(D)(i), as discussed in this proposal. EPA is simultaneously proposing to disapprove California's SIP revision with respect to those Districts in California that do not implement SIP-approved permit programs meeting these approval criteria. For any District for which we finalize a disapproval, EPA intends to simultaneously promulgate a limited Federal Implementation Plan (``FIP''), as discussed in this proposal, unless the relevant area is already subject to a FIP.

36 CFR 296.12 - Relationship to Section 106 of the National Historic Preservation Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Relationship to Section 106 of the National Historic Preservation Act. 296.12 Section 296.12 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROTECTION OF ARCHAEOLOGICAL RESOURCES: UNIFORM REGULATIONS § 296.12 Relationship to Section 106 of the...

33 CFR 153.417 - Reimbursement for actions under section 311(c) or 311(d) of the Act of the Intervention on the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... section 311(c) or 311(d) of the Act of the Intervention on the High Seas Act. 153.417 Section 153.417... Reimbursement for actions under section 311(c) or 311(d) of the Act of the Intervention on the High Seas Act. (a... 311(d) of the Act or under the Intervention on the High Seas Act must, within 60 days after completion...

33 CFR 153.417 - Reimbursement for actions under section 311(c) or 311(d) of the Act of the Intervention on the...

Code of Federal Regulations, 2014 CFR

2014-07-01

... section 311(c) or 311(d) of the Act of the Intervention on the High Seas Act. 153.417 Section 153.417... Reimbursement for actions under section 311(c) or 311(d) of the Act of the Intervention on the High Seas Act. (a... 311(d) of the Act or under the Intervention on the High Seas Act must, within 60 days after completion...

33 CFR 153.417 - Reimbursement for actions under section 311(c) or 311(d) of the Act of the Intervention on the...

Code of Federal Regulations, 2013 CFR

2013-07-01

... section 311(c) or 311(d) of the Act of the Intervention on the High Seas Act. 153.417 Section 153.417... Reimbursement for actions under section 311(c) or 311(d) of the Act of the Intervention on the High Seas Act. (a... 311(d) of the Act or under the Intervention on the High Seas Act must, within 60 days after completion...

19 CFR 145.51 - Articles prohibited by section 305, Tariff Act of 1930.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 2 2013-04-01 2013-04-01 false Articles prohibited by section 305, Tariff Act of 1930. 145.51 Section 145.51 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND...) Obscene matter; (2) Articles for causing unlawful abortion (see § 145.52 for the treatment of literature...

19 CFR 145.51 - Articles prohibited by section 305, Tariff Act of 1930.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 2 2014-04-01 2014-04-01 false Articles prohibited by section 305, Tariff Act of 1930. 145.51 Section 145.51 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND...) Obscene matter; (2) Articles for causing unlawful abortion (see § 145.52 for the treatment of literature...

19 CFR 145.51 - Articles prohibited by section 305, Tariff Act of 1930.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 2 2012-04-01 2012-04-01 false Articles prohibited by section 305, Tariff Act of 1930. 145.51 Section 145.51 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND...) Obscene matter; (2) Articles for causing unlawful abortion (see § 145.52 for the treatment of literature...

19 CFR 145.51 - Articles prohibited by section 305, Tariff Act of 1930.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 2 2011-04-01 2011-04-01 false Articles prohibited by section 305, Tariff Act of 1930. 145.51 Section 145.51 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND...) Obscene matter; (2) Articles for causing unlawful abortion (see § 145.52 for the treatment of literature...

19 CFR 145.51 - Articles prohibited by section 305, Tariff Act of 1930.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Articles prohibited by section 305, Tariff Act of 1930. 145.51 Section 145.51 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND...) Obscene matter; (2) Articles for causing unlawful abortion (see § 145.52 for the treatment of literature...

16 CFR § 1611.39 - Shipments under section 11(c) of the act.

Code of Federal Regulations, 2013 CFR

2013-01-01

...§ 1611.39 Section § 1611.39 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS... finishing or processing to render them not so highly flammable as to be dangerous when worn by individuals... wearing apparel or textile fabric not so highly flammable under section 4 of the act, as to be dangerous...

Section 504 of the Rehabilitation Act: Determining Eligibility and Implications for School Districts

ERIC Educational Resources Information Center

Moses, Marsha; Gilchrest, Cynthia; Schwab, Nadine C.

2005-01-01

Today, school districts are challenged in meeting the health and educational needs of students with chronic health conditions. One of the challenges school districts face is determining when students with health-related disabilities are eligible for services under Section 504 of the Rehabilitation Act of 1973. This article reviews Section 504 and…

76 FR 40817 - Implementation of Section 224 of the Act; A National Broadband Plan for Our Future

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-12

...-50] Implementation of Section 224 of the Act; A National Broadband Plan for Our Future AGENCY... information collection requirements. The Office of Management and Budget (OMB) gave approval for these..., Implementation of Section 224 of the Act; A National Broadband Plan for Our Future. DATES: The final rules...

5 CFR 1315.20 - Application of Section 1010 of the National Defense Authorization Act for Fiscal Year 2001.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Application of Section 1010 of the National Defense Authorization Act for Fiscal Year 2001. 1315.20 Section 1315.20 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES PROMPT PAYMENT § 1315.20 Application of Section 1010 of the National Defense Authorization Act for...

5 CFR 1315.20 - Application of Section 1010 of the National Defense Authorization Act for Fiscal Year 2001.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Application of Section 1010 of the National Defense Authorization Act for Fiscal Year 2001. 1315.20 Section 1315.20 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES PROMPT PAYMENT § 1315.20 Application of Section 1010 of the National Defense Authorization Act for...

5 CFR 1315.20 - Application of Section 1010 of the National Defense Authorization Act for Fiscal Year 2001.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Application of Section 1010 of the National Defense Authorization Act for Fiscal Year 2001. 1315.20 Section 1315.20 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES PROMPT PAYMENT § 1315.20 Application of Section 1010 of the National Defense Authorization Act for...

5 CFR 1315.20 - Application of Section 1010 of the National Defense Authorization Act for Fiscal Year 2001.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Application of Section 1010 of the National Defense Authorization Act for Fiscal Year 2001. 1315.20 Section 1315.20 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES PROMPT PAYMENT § 1315.20 Application of Section 1010 of the National Defense Authorization Act for...

Federal Enforcement for the Section 404 Program of the Clean Water Act

EPA Pesticide Factsheets

Memorandum of Agreement establishing the policy and procedures pursuant to which the Corps and EPA will undertake federal enforcement of the dredged and fill material permit requirements (Section 404 program) of the Clean Water Act (CWA).

40 CFR 89.903 - Application of section 216(10) of the Act.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the applicability of section 216(10) of the Act, an internal combustion engine (including the fuel system) that is not used in a motor vehicle is deemed a nonroad engine if it meets the definition in...

40 CFR 89.903 - Application of section 216(10) of the Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the applicability of section 216(10) of the Act, an internal combustion engine (including the fuel system) that is not used in a motor vehicle is deemed a nonroad engine if it meets the definition in...

78 FR 26775 - Information Collection Request Submitted to OMB for Review and Approval; Comment Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-08

...), Distribution of Offsite Consequence Analysis Information under Section 112(r)(7)(H) of the Clean Air Act (CAA... a risk management plan (RMP) to EPA. The RMP includes information on offsite consequence analyses... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OAR-2003-0073; FRL-9530-6] Information Collection Request...

76 FR 52946 - Clean Air Act Operating Permit Program; Petition for Objection to State Operating Permit for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-24

...This document announces that the EPA Administrator has responded to a citizen petition asking EPA to object to an operating permit (Permit Number P026R2) issued by the New Mexico Environment Department, Air Quality Bureau (NMED). Specifically, the Administrator has granted the April 14, 2010 petition, submitted by WildEarth Guardians and San Juan Citizens Alliance (Petitioners) to object to the March 19, 2010, operating permit issued to Williams Four Corners, LLC, for the Sims Mesa Central Delivery Point (CDP) compressor station in northwestern Rio Arriba County, New Mexico. Pursuant to sections 307(b) and 505(b)(2) of the Clean Air Act (CAA), a petition for judicial review of those parts of the Order that deny issues in the petition may be filed in the United States Court of Appeals for the appropriate circuit within 60 days from the date this notice appears in the Federal Register.

76 FR 47062 - Approval and Promulgation of Air Quality Implementation Plans; West Virginia; Section 110(a)(2...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-04

... 22, 2008: 110(a)(2)(A), (B), (C), (D)(ii), (E), (F), (G), (H), (J), (K), (L), and (M), or portions... CAA section 110(a)(2)(A), (B), (C), (D)(ii), (E), (F), (G), (H), (J), (K), (L), and (M), or portions... sections 110(a)(2)(A), (B), (C), (D)(ii), (E), (F), (G), (H), (J), (K), (L), and (M), or portions thereof...

17 CFR 250.14 - Exemption of acquisitions of securities of power supply companies from section 9(a)(2) of the Act.

Code of Federal Regulations, 2011 CFR

2011-04-01

... securities of power supply companies from section 9(a)(2) of the Act. 250.14 Section 250.14 Commodity and... of securities of power supply companies from section 9(a)(2) of the Act. (a) An electric utility... exempt from section 9(a)(2) of the Act with respect to the acquisition of any security of a power supply...

17 CFR 250.14 - Exemption of acquisitions of securities of power supply companies from section 9(a)(2) of the Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... securities of power supply companies from section 9(a)(2) of the Act. 250.14 Section 250.14 Commodity and... of securities of power supply companies from section 9(a)(2) of the Act. (a) An electric utility... exempt from section 9(a)(2) of the Act with respect to the acquisition of any security of a power supply...

17 CFR 170.5 - Prevention of fraudulent and manipulative practices (section 17(b)(7) of the Act).

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Prevention of fraudulent and... of Applications for Registration as a Futures Association Under Section 17 of the Act § 170.5 Prevention of fraudulent and manipulative practices (section 17(b)(7) of the Act). A futures association must...

21 CFR 1210.28 - Permits waiving clause 4, section 2 of the Federal Import Milk Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Import Milk Act. 1210.28 Section 1210.28 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND DRUG ADMINISTRATION REGULATIONS UNDER THE FEDERAL IMPORT MILK ACT Permit Control § 1210.28 Permits...

21 CFR 1210.28 - Permits waiving clause 4, section 2 of the Federal Import Milk Act.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Import Milk Act. 1210.28 Section 1210.28 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND DRUG ADMINISTRATION REGULATIONS UNDER THE FEDERAL IMPORT MILK ACT Permit Control § 1210.28 Permits...

76 FR 57619 - Delegation Under Section 2(A) of the Special Agent Samuel Hicks Families of Fallen Heroes Act

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-15

...--Delegation Under Section 2(A) of the Special Agent Samuel Hicks Families of Fallen Heroes Act Presidential... Hicks Families of Fallen Heroes Act Memorandum for the Administrator of General Services By the... the President by section 2(a) of the Special Agent Samuel Hicks Families of Fallen Heroes Act (Public...

Significance of different carbon forms and carbonic anhydrase activity in monitoring and prediction of algal blooms in the urban section of Jialing River, Chongqing, China.

PubMed

Nie, Yudong; Zhang, Zhi; Shen, Qian; Gao, Wenjin; Li, Yingfan

2016-05-18

The Three Gorges Dam is one of the largest hydroelectric power plants worldwide; its reservoir was preliminarily impounded in 2003 and finally impounded to 175 m in 2012. The impoundment caused some environmental problems, such as algal blooms. Carbonic anhydrase (CA) is an important biocatalyst in the carbon utilization by algae and plays an important role in algal blooms. CA has received considerable attention for its role in red tides in oceans, but less investigation has been focused on its role in algal blooms in fresh water. In this study, the seasonal variation of water quality parameters, different carbon forms, carbonic anhydrase activity (CAA), and the algal cell density of four sampling sites in the urban section of the Jialing River were investigated from November 1, 2013 to October 31, 2014. Results indicated that CAA exhibited a positive correlation with dissoluble organic carbon (DOC), pH, and temperature, but a negative correlation with CO2 and dissoluble inorganic carbon (DIC). Algal cell density exhibited a positive correlation with flow velocity (V), pH, particulate organic carbon (POC), and CAA, a negative correlation with CO2, and a negative partial correlation with DIC. The relationship between CAA and algal cell density for the entire year can be described as cells = 23.278CAA - 42.666POC + 139.547pH - 1057.106. The algal bloom prediction model for the key control period can be described as cells = -45.895CAA + 776.103V- 29.523DOC + 14.219PIC + 35.060POC + 19.181 (2 weeks in advance) and cells = 69.200CAA + 203.213V + 4.184CO2 + 38.911DOC + 40.770POC - 189.567 (4 weeks in advance). The findings in this study demonstrate that the carbon utilization by algae is conducted by CA and provide a new method of monitoring algal cell density and predicting algal blooms.

Your Rights under Section 504 of the Rehabilitation Act. Fact Sheet

ERIC Educational Resources Information Center

US Department of Health and Human Services, 2006

2006-01-01

Section 504 of the Rehabilitation Act of 1973 is a national law that protects qualified individuals from discrimination based on their disability. The nondiscrimination requirements of the law apply to employers and organizations that receive financial assistance from any Federal department or agency, including the U.S. Department of Health and…

18 CFR 284.263 - Exemption from section 7 of Natural Gas Act and certain regulatory conditions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 7 of Natural Gas Act and certain regulatory conditions. 284.263 Section 284.263 Conservation of... UNDER THE NATURAL GAS POLICY ACT OF 1978 AND RELATED AUTHORITIES CERTAIN SALES AND TRANSPORTATION OF NATURAL GAS UNDER THE NATURAL GAS POLICY ACT OF 1978 AND RELATED AUTHORITIES Emergency Natural Gas Sale...

18 CFR 284.263 - Exemption from section 7 of Natural Gas Act and certain regulatory conditions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 7 of Natural Gas Act and certain regulatory conditions. 284.263 Section 284.263 Conservation of... UNDER THE NATURAL GAS POLICY ACT OF 1978 AND RELATED AUTHORITIES CERTAIN SALES AND TRANSPORTATION OF NATURAL GAS UNDER THE NATURAL GAS POLICY ACT OF 1978 AND RELATED AUTHORITIES Emergency Natural Gas Sale...

28 CFR Appendix to Part 51 - Jurisdictions Covered Under Section 4(b) of the Voting Rights Act, as Amended

Code of Federal Regulations, 2011 CFR

2011-07-01

...) of the Voting Rights Act, as Amended Appendix to Part 51 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR THE ADMINISTRATION OF SECTION 5 OF THE VOTING RIGHTS ACT OF 1965, AS AMENDED Pt. 51, App. Appendix to Part 51—Jurisdictions Covered Under Section 4(b) of the Voting Rights Act...

28 CFR Appendix to Part 51 - Jurisdictions Covered Under Section 4(b) of the Voting Rights Act, as Amended

Code of Federal Regulations, 2010 CFR

2010-07-01

...) of the Voting Rights Act, as Amended Appendix to Part 51 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR THE ADMINISTRATION OF SECTION 5 OF THE VOTING RIGHTS ACT OF 1965, AS AMENDED Pt. 51, App. Appendix to Part 51—Jurisdictions Covered Under Section 4(b) of the Voting Rights Act...

Bioenergetics at extreme temperature: Thermus thermophilus ba(3)- and caa(3)-type cytochrome c oxidases.

PubMed

Radzi Noor, Mohamed; Soulimane, Tewfik

2012-04-01

Seven years into the completion of the genome sequencing projects of the thermophilic bacterium Thermus thermophilus strains HB8 and HB27, many questions remain on its bioenergetic mechanisms. A key fact that is occasionally overlooked is that oxygen has a very limited solubility in water at high temperatures. The HB8 strain is a facultative anaerobe whereas its relative HB27 is strictly aerobic. This has been attributed to the absence of nitrate respiration genes from the HB27 genome that are carried on a mobilizable but highly-unstable plasmid. In T. thermophilus, the nitrate respiration complements the primary aerobic respiration. It is widely known that many organisms encode multiple biochemically-redundant components of the respiratory complexes. In this minireview, the presence of the two cytochrome c oxidases (CcO) in T. thermophilus, the ba(3)- and caa(3)-types, is outlined along with functional considerations. We argue for the distinct evolutionary histories of these two CcO including their respective genetic and molecular organizations, with the caa(3)-oxidase subunits having been initially 'fused'. Coupled with sequence analysis, the ba(3)-oxidase crystal structure has provided evolutionary and functional information; for example, its subunit I is more closely related to archaeal sequences than bacterial and the substrate-enzyme interaction is hydrophobic as the elevated growth temperature weakens the electrostatic interactions common in mesophiles. Discussion on the role of cofactors in intra- and intermolecular electron transfer and proton pumping mechanism is also included. Copyright © 2011 Elsevier B.V. All rights reserved.

77 FR 39458 - Approval and Promulgation of Air Quality Implementation Plans; West Virginia; Section 110(a)(2...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-03

... for the 2008 Lead National Ambient Air Quality Standards AGENCY: Environmental Protection Agency (EPA... (CAA) section 110(a)(2) necessary to implement, maintain, and enforce the 2008 lead national ambient... On October 15, 2008, EPA substantially strengthened the primary and secondary lead NAAQS (hereafter...

3 CFR - Delegation of Waiver Authority Under Section 1022(a)(4) of the National Defense Authorization Act...

Code of Federal Regulations, 2013 CFR

2013-01-01

... 3 The President 1 2013-01-01 2013-01-01 false Delegation of Waiver Authority Under Section 1022(a)(4) of the National Defense Authorization Act for Fiscal Year 2012 Presidential Documents Other Presidential Documents Memorandum of February 28, 2012 Delegation of Waiver Authority Under Section 1022(a)(4) of the National Defense Authorization Act...

75 FR 26956 - Clean Water Act Section 303(d): Availability of Los Angeles Area Lakes Total Maximum Daily Loads...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-13

... included on the State of California's Section 303(d) list of polluted waters due to water quality impacts... ENVIRONMENTAL PROTECTION AGENCY [FRL-9146-6] Clean Water Act Section 303(d): Availability of Los... nutrient, mercury, chlordane, dieldrin, DDT, PCB, and trash impairments pursuant to Clean Water Act Section...

40 CFR 63.10448 - What definitions apply to this subpart?

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) National Emission Standards for Hospital Ethylene Oxide Sterilizers Other Requirements and... Clean Air Act (CAA), in 40 CFR 63.2, and in this section as follows: Aeration process means any time... equipment that reduces the quantity of ethylene oxide in the effluent gas stream from sterilization and...

40 CFR 63.10448 - What definitions apply to this subpart?

Code of Federal Regulations, 2011 CFR

2011-07-01

... (CONTINUED) National Emission Standards for Hospital Ethylene Oxide Sterilizers Other Requirements and... Clean Air Act (CAA), in 40 CFR 63.2, and in this section as follows: Aeration process means any time... equipment that reduces the quantity of ethylene oxide in the effluent gas stream from sterilization and...

76 FR 72626 - Approval and Promulgation of Air Quality Implementation Plans; Delaware; Amendments to the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-25

.... (See section 307(b)(2).) List of Subjects in 40 CFR part 52 Environmental protection, Air pollution... Promulgation of Air Quality Implementation Plans; Delaware; Amendments to the Control of Volatile Organic... accordance with the requirements of the Clean Air Act (CAA). DATES: Effective Date: This final rule is...

Antioxidant activity of puha (Sonchus oleraceus L.) as assessed by the cellular antioxidant activity (CAA) assay.

PubMed

McDowell, Arlene; Thompson, Scott; Stark, Mirjam; Ou, Zong-Quan; Gould, Kevin S

2011-12-01

There is considerable interest in antioxidant dietary components that can be protective against degenerative diseases in humans. Puha (Sonchus oleraceus L.) is a rich source of polyphenols, and exhibits strong antioxidant activity as measured by the 2,2-diphenylpicrylhydrazyl (DPPH) assay. However, the potential of puha to protect against degenerative diseases requires that low molecular weight antioxidants (LMWA) are absorbed by, and active in, human cells. The cellular antioxidant activity (CAA) assay was used to investigate the antioxidant activity of puha leaf extracts. Preparation methods of freezing and freeze-drying reduced the total polyphenolic content compared with fresh puha, but did not affect the LMWA potential as determined by the DPPH assay. The IC(50) values were 0.012 ± 0.003 mg/mL and 0.010 ± 0.005 mg/mL for freeze-dried and fresh puha leaves, respectively. Using the CAA assay, it was shown that LMWAs from foliar extracts of puha were effectively absorbed into HepG2 cells, and exerted antioxidant activity at levels comparable to those of extracts from blueberry fruits, the much-touted antioxidant superfood. Methylene blue staining of HepG2 cells indicated that puha extracts were not cytotoxic at concentrations below 100 mg DW/mL. The data indicate the potential of puha as a nutraceutical supplement for human health. Copyright © 2011 John Wiley & Sons, Ltd.

77 FR 11369 - Delegation of Certain Function Under Section 308(a) of the Intelligence Authorization Act for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-24

... Vol. 77 Friday, No. 37 February 24, 2012 Part V The President Memorandum of January 27, 2012--Delegation of Certain Function Under Section 308(a) of the Intelligence Authorization Act for Fiscal Year 2012 Memorandum of January 30, 2012--Delegation of Authority in Accordance With Sections 610 and 652 of the Foreign Assistance Act of 1961, as...

77 FR 18051 - Approval and Promulgation of Implementation Plans; State of Colorado; Regional Haze State...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-26

...EPA is proposing to approve a State implementation plan (SIP) revision submitted by the State of Colorado on May 25, 2011 that addresses regional haze (RH). EPA is proposing to determine that the plan submitted by Colorado satisfies the requirements of the Clean Air Act (CAA or ``the Act'') and our rules that require states to prevent any future and remedy any existing man-made impairment of visibility in mandatory Class I areas caused by emissions of air pollutants from numerous sources located over a wide geographic area (also referred to as the ``regional haze program''). States are required to assure reasonable progress toward the national goal of achieving natural visibility conditions in Class I areas. EPA is taking this action pursuant to section 110 of the CAA.

Status of Clean Air Act (CAA) 110(a)(2)(D)(i)(I) SIPs Final Rule TSD

EPA Pesticide Factsheets

This document describes, for each state subject to a Federal implementation plan (FIP) with respect to ozone and/or PM2.5 NAAQS under the Transport Rule, the status of each Clean Air Act state implementation plan (SIP) for the relevant NAAQS.

12 CFR 225.113 - Services under section 4(a) of Bank Holding Company Act.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Company Act. 225.113 Section 225.113 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.113 Services under section 4(a) of Bank Holding...

19 CFR 162.73 - Penalties under section 592, Tariff Act of 1930, as amended.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Penalties under section 592, Tariff Act of 1930, as amended. 162.73 Section 162.73 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) INSPECTION, SEARCH, AND SEIZURE Special...

29 CFR 516.27 - “Board, lodging, or other facilities” under section 3(m) of the Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false âBoard, lodging, or other facilitiesâ under section 3(m) of...” under section 3(m) of the Act. (a) In addition to keeping other records required by this part, an... these terms are used in sec. 3(m) of the Act) furnished to them by the employer or by an affiliated...

29 CFR 516.27 - “Board, lodging, or other facilities” under section 3(m) of the Act.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 3 2011-07-01 2011-07-01 false âBoard, lodging, or other facilitiesâ under section 3(m) of...” under section 3(m) of the Act. (a) In addition to keeping other records required by this part, an... these terms are used in sec. 3(m) of the Act) furnished to them by the employer or by an affiliated...

8 CFR 1245.3 - Adjustment of status under section 13 of the Act of September 11, 1957, as amended.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Adjustment of status under section 13 of... OF PERSON ADMITTED FOR PERMANENT RESIDENCE § 1245.3 Adjustment of status under section 13 of the Act of September 11, 1957, as amended. Any application for benefits under section 13 of the Act of...

76 FR 73989 - Redelegation of Authority Under Section 3 of the Housing and Urban Development Act of 1968

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-29

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5544-D-09] Redelegation of Authority Under Section 3 of the Housing and Urban Development Act of 1968 AGENCY: Office of the Assistant... delegated authority under Section 3 of the Housing and Urban Development Act of 1968 and HUD's implementing...

DMCA Section 104 Report: A Report of the Register of Copyrights Pursuant to [Section] 104 of the Digital Millennium Copyright Act.

ERIC Educational Resources Information Center

Library of Congress, Washington, DC. Copyright Office.

As required under section 104 of Public Law No. 105-304, this Report evaluates the effects of title I of the Digital Millennium Copyright Act (DMCA) of 1998 and the development of electronic commerce and associated technology on the operation of sections 109 and 117 of title 17, U.S.C. It also evaluates the relationship between existing and…

78 FR 26739 - Notice of Final Action on Petition From Earthjustice To List Coal Mines as a Source Category and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-08

... Action on Petition From Earthjustice To List Coal Mines as a Source Category and To Regulate Air Emissions From Coal Mines AGENCY: Environmental Protection Agency (EPA). ACTION: Denial of petition for... Perciasepe, signed a letter denying a petition to add coal mines to the Clean Air Act (CAA) section 111 list...

78 FR 11119 - Air Quality: Revision to Definition of Volatile Organic Compounds-Exclusion of trans

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-15

... tropospheric ozone formation. In the ``Rules and Regulations'' section of this Federal Register, we are making... compound makes a negligible contribution to tropospheric ozone formation.\\1\\ We are publishing a direct... standards for ozone under title I of the Clean Air Act (CAA). This proposed revision would add trans 1...

77 FR 33945 - Delegation of Reporting Functions Specified in Section 8 of the Belarus Democracy Act of 2004, as...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-08

... of Reporting Functions Specified in Section 8 of the Belarus Democracy Act of 2004, as Amended... laws of the United States of America, including section 301 of title 3 of the United States Code, I... Democracy Act of 2004 (Public Law 109-480; 22 U.S.C. 5811 note), as amended by section 5 of the Belarus...

18 CFR 16.18 - Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.18 Section 16.18 Conservation of Power... Projects Subject to Sections 14 and 15 of the Federal Power Act § 16.18 Annual licenses for projects...

18 CFR 16.18 - Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.18 Section 16.18 Conservation of Power... Projects Subject to Sections 14 and 15 of the Federal Power Act § 16.18 Annual licenses for projects...

18 CFR 16.18 - Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.18 Section 16.18 Conservation of Power... Projects Subject to Sections 14 and 15 of the Federal Power Act § 16.18 Annual licenses for projects...

18 CFR 16.18 - Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.18 Section 16.18 Conservation of Power... Projects Subject to Sections 14 and 15 of the Federal Power Act § 16.18 Annual licenses for projects...

18 CFR 16.18 - Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.18 Section 16.18 Conservation of Power... Projects Subject to Sections 14 and 15 of the Federal Power Act § 16.18 Annual licenses for projects...

8 CFR 245.3 - Adjustment of status under section 13 of the Act of September 11, 1957, as amended.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Adjustment of status under section 13 of... RESIDENCE § 245.3 Adjustment of status under section 13 of the Act of September 11, 1957, as amended. Any application for benefits under section 13 of the Act of September 11, 1957, as amended, must be filed on Form...

21 CFR 860.95 - Exemptions from sections 510, 519, and 520(f) of the act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Exemptions from sections 510, 519, and 520(f) of the act. 860.95 Section 860.95 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... (records and reports), and section 520(f) (good manufacturing practice requirements of the quality system...

8 CFR 245.8 - Adjustment of status as a special immigrant under section 101(a)(27)(K) of the Act.

Code of Federal Regulations, 2014 CFR

2014-01-01

... under section 101(a)(27)(K) of the Act. 245.8 Section 245.8 Aliens and Nationality DEPARTMENT OF... RESIDENCE § 245.8 Adjustment of status as a special immigrant under section 101(a)(27)(K) of the Act. (a) Application. Each person applying for adjustment of status as a special immigrant under section 101(a)(27)(K...

76 FR 48002 - Approval and Promulgation of Air Quality Implementation Plans; State of California; Interstate...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-08

...EPA is finalizing a limited approval and limited disapproval of a state implementation plan (SIP) revision submitted by the State of California on November 17, 2007, to address the ``transport SIP'' provisions of Clean Air Act (CAA) section 110(a)(2)(D)(i) for the 1997 8-hour ozone National Ambient Air Quality Standards (NAAQS or standards) and the 1997 fine particulate matter (PM2.5) NAAQS. Section 110(a)(2)(D)(i) of the CAA requires that each SIP contain, among other things, adequate measures prohibiting emissions of air pollutants in amounts which will interfere with any other State's measures required under title I, part C of the CAA to prevent significant deterioration of air quality. EPA is approving California's SIP revision with respect to those Districts that implement SIP- approved permit programs meeting the approval criteria and simultaneously disapproving California's SIP revision with respect to those Districts that do not implement SIP-approved permit programs meeting the approval criteria, as discussed in our May 31, 2011 proposed rule (76 FR 31263).

75 FR 44893 - Pipeline Posting Requirements Under Section 23 of the Natural Gas Act

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-30

... and RM08-2-000; Order No. 720-B] Pipeline Posting Requirements Under Section 23 of the Natural Gas Act... R. Norris, and Cheryl A. LaFleur. Pipeline Posting Requirements under Section 23 of the Natural Gas...) issued Order No. 720 requiring interstate and certain major non-interstate natural gas pipelines to post...

THE CHALLENGES OF AIR POLLUTION AND RESIDUAL RISK ASSESSMENT (EDITORIAL)

EPA Science Inventory

The Clean Air Act (CAA), a comprehensive federal law that regulates air pollution from stationary and mobile sources, was first passed in 1963. The act has provided the primary framework for protecting human health and the environment. The CAA divides air pollutants into "criteri...

Summary of Waiver Requests Under Section 211(f) of the Clean Air Act

EPA Pesticide Factsheets

This document summarizes the waiver requests that EPA has received under Section 211(f) of the Clean Air Act, including docket numbers, federal register citations, and the actions that were taken by EPA for each request.

Clean Air Act, TRI drive emission reduction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heller, K.

1994-06-22

When asked to rank priority environmental engineering projects, many chemical firms put emissions reduction first. The chief motivators are the need to comply with rules governing major sources of hazardous air pollutants (HAPS) under the Clean Air Act Amendments of 1990 (CAA), along with the need to reduce the volumes of chemicals on EPA`s Toxics Release Inventory (TRI). Deep-welling of toxics is getting special attention as the practice adds considerably to TRI numbers. {open_quotes}We want to eliminate our air toxics so that we can get entirely out of the [CAA] Maximum Achievable Control Technology (MACT) requirements,{close_quotes} says Thomas Zosel, manager/pollutionmore » prevention programs for 3M (St. Paul, MN). He estimates that 3M`s 1993 total research expenditures for environmental improvements were at least $200 million, out of an annual research budget of a little more than $1 billion. And, he says, the spending level is not expected to drop. Among its many efforts, 3M is striving to move away from solvents in all of its processes. To help reach that goal, the company developed a {open_quotes}waste measurement metric{close_quotes} that calculates the wastes produced by each of the company`s 50 operating divisions. In the case of Magic Tape, the company eliminated solvent emission by switching to a water-based adhesive that does not require a solvent.« less

78 FR 34970 - Approval and Promulgation of Air Quality Implementation Plans; Virginia; Section 110(a)(2...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-11

... submitted by the Commonwealth of Virginia addressing the basic program elements specified in 110(a)(2) of... action does not include the nonattainment requirements of part D, Title I (referred to as element I), since this element is not required to be submitted by the 3-year submission deadline of CAA section 110...

78 FR 5347 - Denial of Reconsideration Petition on Model Year 2012-2016 Light Duty Vehicle Greenhouse Gas...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-25

... issue until November 10, 2010, when EPA replied to PLF's Freedom of Information Act request seeking... seeking judicial review (i.e. within 60 days of the rule's publication--July 10, 2010), as required by CAA... Document (EPA-420-R-10-012, April 2010), section 3. There were no judicial challenges to the rule's...

78 FR 73698 - Prevention of Significant Deterioration for Particulate Matter Less Than 2.5 Micrometers...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-09

... Administrative Procedure Act (APA) good cause exemption applies here. In general, the APA requires that general... opportunity for public participation in the rulemaking process. However, the APA does provide an avenue for an... of the APA, 5 U.S.C. 553(b)(B). Therefore, the requirements of CAA section 307(d), including the...

75 FR 10415 - Approval and Promulgation of Air Quality Implementation Plans; Wisconsin; NSR Reform Regulations...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-08

... on May 25, 2006. The Wisconsin Department of Natural Resources sought approval of rule AM-06-04 to... reconsideration pursuant to section 307(d)(7)(B) of the Clean Air Act (CAA) from the Natural Resources Defense... these documents will be available on the World Wide Web. Following signature by the Assistant...

77 FR 55417 - Approval and Promulgation of Air Quality Implementation Plans; West Virginia; Section 110(a)(2...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-10

... for the 2008 Lead National Ambient Air Quality Standards AGENCY: Environmental Protection Agency (EPA... national ambient air quality standards (NAAQS). DATES: This final rule is effective on October 10, 2012... promulgation of such NAAQS. Section 110(a)(2) of the CAA directs all states to develop and maintain an air...

17 CFR 229.405 - (Item 405) Compliance with section 16(a) of the Exchange Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

....C. 78l), every closed-end investment company registered under the Investment Company Act of 1940 (15 U.S.C. 80a-1 et seq.), and every holding company registered pursuant to the Public Utility Holding... or section 17 of the Public Utility Holding Company Act (“reporting person”) that failed to file on a...

3 CFR - Delegation of Authority Pursuant to Section 404(c) of the Child Soldiers Prevention Act of 2008...

Code of Federal Regulations, 2014 CFR

2014-01-01

... 3 The President 1 2014-01-01 2014-01-01 false Delegation of Authority Pursuant to Section 404(c) of the Child Soldiers Prevention Act of 2008, as Amended Presidential Documents Other Presidential Documents Memorandum of August 2, 2013 Delegation of Authority Pursuant to Section 404(c) of the Child Soldiers Prevention Act of 2008, as Amended...

RNA editing in the anticodon of tRNA Leu (CAA) occurs before group I intron splicing in plastids of a moss Takakia lepidozioides S. Hatt. & Inoue.

PubMed

Miyata, Y; Sugita, C; Maruyama, K; Sugita, M

2008-03-01

RNA editing of cytidine (C) to uridine (U) transitions occurs in plastids and mitochondria of most land plants. In this study, we amplified and sequenced the group I intron-containing tRNA Leu gene, trnL-CAA, from Takakia lepidozioides, a moss. DNA sequence analysis revealed that the T. lepidozioides tRNA Leu gene consisted of a 35-bp 5' exon, a 469-bp group I intron and a 50-bp 3' exon. The intron was inserted between the first and second position of the tRNA Leu anticodon. In general, plastid tRNA Leu genes with a group I intron code for a TAA anticodon in most land plants. This strongly suggests that the first nucleotide of the CAA anticodon could be edited in T. lepidozioides plastids. To investigate this possibility, we analysed cDNAs derived from the trnL-CAA transcripts. We demonstrated that the first nucleotide C of the anticodon was edited to create a canonical UAA anticodon in T. lepidozioides plastids. cDNA sequencing analyses of the spliced or unspliced tRNA Leu transcripts revealed that, while the spliced tRNA was completely edited, editing in the unspliced tRNAs were only partial. This is the first experimental evidence that the anticodon editing of tRNA occurs before RNA splicing in plastids. This suggests that this editing is a prerequisite to splicing of pre-tRNA Leu.

75 FR 4805 - Electricity Market Transparency Provisions of Section 220 of the Federal Power Act

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-29

...,039] Electricity Market Transparency Provisions of Section 220 of the Federal Power Act January 21... MWh of electricity per year) from the Commission's jurisdiction.\\3\\ However, section 201(b)(2) states... collect ``information about the availability and prices'' of natural gas and electricity sold at wholesale...

Development of a multiplex allele-specific primer PCR assay for simultaneous detection of QoI and CAA fungicide resistance alleles in Plasmopara viticola populations.

PubMed

Aoki, Yoshinao; Hada, Yosuke; Suzuki, Shunji

2013-02-01

DNA-based diagnosis has become a common tool for the evaluation of fungicide resistance in obligate phytopathogenic fungus Plasmopara viticola. A multiplex allele-specific primer PCR assay has been developed for the rapid detection of fungicide resistance in P. viticola populations. With this assay, a glycine-to-alanine substitution at codon 143 of the P. viticola cytochrome b gene, which conferred QoI fungicide resistance, and a glycine-to-serine substitution at codon 1105 of the P. viticola cellulose synthase gene PvCesA3, which conferred CAA fungicide resistance, were detected simultaneously. It is suggested that the present assay is a reliable tool for the rapid and simultaneous detection of QoI and CAA fungicide resistance alleles in P. viticola populations. The assay required only 2 h from the sampling of symptoms to the detection of resistance alleles to both fungicides. Copyright © 2012 Society of Chemical Industry.

Measures of Effectiveness-CONUS Reorganization 1973 (As Pertains to FORSCOM, TRADOC, HSC, OTEA and CAA). Volume I. Executive Summary

DTIC Science & Technology

1974-11-01

obvioun that they were’ dkep]y corncented a d halrd at work in &,tvrloping meaw to masure their rmT effectiveness . This proposed eval- tiatiot plIn wilt be...AD/A-002 532 MEASURES OF EFFECTIVENESS -CONUS REORCAN- IZATION 1973 (AS PERTAINS TO FORSCOM. TRADOC, HSC, OTEA AND CAA). VOLUME I.EXECUTIVE SUMMARY M...resulting Interaction organizational objective goal effectiveness imovati ye chanuge vrasurement are a The study provider, an evaluatinn plan, "ased

77 FR 20020 - Clean Water Act Section 303(d): Availability of List Decisions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-03

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9655-2] Clean Water Act Section 303(d): Availability of List Decisions AGENCY: Environmental Protection Agency. ACTION: Notice of availability. SUMMARY: This notice announces the availability of EPA's Responsiveness Summary Concerning EPA's November 30, 2011, Public Notice...

75 FR 68783 - Clean Water Act Section 303(d): Availability of List Decisions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-09

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9223-5] Clean Water Act Section 303(d): Availability of List Decisions AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of availability. SUMMARY: This action announces the availability of EPA decisions identifying water quality limited segments and...

24 CFR 1000.42 - Are the requirements of section 3 of the Housing and Urban Development Act of 1968 applicable?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Are the requirements of section 3 of the Housing and Urban Development Act of 1968 applicable? 1000.42 Section 1000.42 Housing and... ACTIVITIES General § 1000.42 Are the requirements of section 3 of the Housing and Urban Development Act of...

10 CFR 8.1 - Interpretation of section 152 of the Atomic Energy Act of 1954; opinion of the General Counsel.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Interpretation of section 152 of the Atomic Energy Act of 1954; opinion of the General Counsel. 8.1 Section 8.1 Energy NUCLEAR REGULATORY COMMISSION INTERPRETATIONS § 8.1 Interpretation of section 152 of the Atomic Energy Act of 1954; opinion of the General...

10 CFR 8.1 - Interpretation of section 152 of the Atomic Energy Act of 1954; opinion of the General Counsel.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Interpretation of section 152 of the Atomic Energy Act of 1954; opinion of the General Counsel. 8.1 Section 8.1 Energy NUCLEAR REGULATORY COMMISSION INTERPRETATIONS § 8.1 Interpretation of section 152 of the Atomic Energy Act of 1954; opinion of the General...

10 CFR 8.1 - Interpretation of section 152 of the Atomic Energy Act of 1954; opinion of the General Counsel.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Interpretation of section 152 of the Atomic Energy Act of 1954; opinion of the General Counsel. 8.1 Section 8.1 Energy NUCLEAR REGULATORY COMMISSION INTERPRETATIONS § 8.1 Interpretation of section 152 of the Atomic Energy Act of 1954; opinion of the General...

16 CFR 1611.39 - Shipments under section 11(c) of the act.

Code of Federal Regulations, 2011 CFR

2011-01-01

... undersigned or by a duly authorized agent so as to render them not so highly flammable under the provisions of.... 1611.39 Section 1611.39 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT... processing to render them not so highly flammable as to be dangerous when worn by individuals, shall contain...

16 CFR 1611.39 - Shipments under section 11(c) of the act.

Code of Federal Regulations, 2014 CFR

2014-01-01

... undersigned or by a duly authorized agent so as to render them not so highly flammable under the provisions of.... 1611.39 Section 1611.39 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT... processing to render them not so highly flammable as to be dangerous when worn by individuals, shall contain...

16 CFR 1611.39 - Shipments under section 11(c) of the act.

Code of Federal Regulations, 2012 CFR

2012-01-01

... undersigned or by a duly authorized agent so as to render them not so highly flammable under the provisions of.... 1611.39 Section 1611.39 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT... processing to render them not so highly flammable as to be dangerous when worn by individuals, shall contain...

75 FR 20351 - Clean Water Act Section 303(d): Availability of One Total Maximum Daily Load (TMDL) in Arkansas

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-19

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9139-5] Clean Water Act Section 303(d): Availability of One...: Notice of availability. SUMMARY: This notice announces the availability of the administrative record file... in the State of Arkansas under Section 303(d) of the Clean Water Act (CWA). This TMDL was completed...

77 FR 60731 - Notice of Applications for Deregistration Under Section 8(f) of the Investment Company Act of 1940

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-04

...) 551-6810, SEC, Division of Investment Management, Office of Investment Company Regulation, 100 F... Deregistration Under Section 8(f) of the Investment Company Act of 1940 September 28, 2012. The following is a notice of applications for deregistration under section 8(f) of the Investment Company Act of 1940 for...

76 FR 52387 - Approval and Promulgation of Implementation Plans; New Mexico; Federal Implementation Plan for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

...EPA is disapproving a portion of the State Implementation Plan (SIP) revision received from the State of New Mexico on September 17, 2007, for the purpose of addressing the ``good neighbor'' requirements of section 110(a)(2)(D)(i) of the Clean Air Act (CAA or Act) for the 1997 8-hour ozone National Ambient Air Quality Standards (NAAQS or standards) and the 1997 fine particulate matter (PM2.5) NAAQS. In this action, EPA is disapproving the New Mexico Interstate Transport SIP provisions that address the requirement of section 110(a)(2)(D)(i)(II) that emissions from New Mexico sources do not interfere with measures required in the SIP of any other state under part C of the CAA to protect visibility. We have found that New Mexico sources, except the San Juan Generating Station, are sufficiently controlled to eliminate interference with the visibility programs of other states. EPA is promulgating a Federal Implementation Plan (FIP) to address this deficiency by implementing nitrogen oxides (NOX) and sulfur dioxide (SO2) emission limits necessary at the San Juan Generating Station (SJGS), to prevent such interference. EPA found in January 2009 that New Mexico had failed to submit a SIP addressing certain regional haze (RH) requirements, including the requirement for best available retrofit technology (BART). The Clean Air Act required EPA to promulgate a FIP to address RH requirements by January 2011. This FIP addresses the RH BART requirement for NOX for SJGS. In addition, EPA is implementing sulfuric acid (H2SO4) hourly emission limits at the SJGS, to minimize the contribution of this compound to visibility impairment. This action is being taken under section 110 and part C of the CAA.

76 FR 34872 - Approval and Promulgation of Implementation Plans; State of California; Regional Haze and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-15

... that they have either received TAS or completed the application process for TAS under the Clean Water.... Similarly, we also do not need to address the Tribes' comment regarding TAS under the Clean Water Act as...-polluting fuels or use advanced control technology to reduce emissions of NO X (CAA section 182(e)(3)). \\14...

76 FR 1579 - Approval and Promulgation of Implementation Plans; State of Idaho; Regional Haze State...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-11

... 25, 2010, as meeting the requirements of Clean Air Act (CAA) section 110(a)(2)(D)(i)(II) as it... Web site is an ``anonymous access'' system, which means EPA will not know your identity or contact...,'' or ``our'' is used, we mean the EPA. Information is organized as follows: Table of Contents I...

20 CFR 652.204 - Must funds authorized under section 7(b) of the Act (the Governor's reserve) flow through the One...

Code of Federal Regulations, 2010 CFR

2010-04-01

... the Act (the Governor's reserve) flow through the One-Stop delivery system? 652.204 Section 652.204... FUNCTIONING OF STATE EMPLOYMENT SERVICES Wagner-Peyser Act Services in a One-Stop Delivery System Environment § 652.204 Must funds authorized under section 7(b) of the Act (the Governor's reserve) flow through the...

26 CFR 7.48-3 - Election to apply the amendments made by sections 804 (a) and (b) of the Tax Reform Act of 1976...

Code of Federal Regulations, 2010 CFR

2010-04-01

... the Act to movie and television films that are property described in section 50(a) of the Code and... sections 804 (a) and (b) of the Tax Reform Act of 1976 to property described in section 50(a) of the Code... described in section 50(a) of the Code. (a) General rule. Under section 804(e)(2) of the Tax Reform Act of...

21 CFR 108.19 - Establishment of requirements for exemption from section 404 of the act.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Establishment of requirements for exemption from section 404 of the act. 108.19 Section 108.19 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION EMERGENCY PERMIT CONTROL General...

21 CFR 108.19 - Establishment of requirements for exemption from section 404 of the act.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Establishment of requirements for exemption from section 404 of the act. 108.19 Section 108.19 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION EMERGENCY PERMIT CONTROL General...

21 CFR 108.19 - Establishment of requirements for exemption from section 404 of the act.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Establishment of requirements for exemption from section 404 of the act. 108.19 Section 108.19 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION EMERGENCY PERMIT CONTROL General...

21 CFR 108.19 - Establishment of requirements for exemption from section 404 of the act.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Establishment of requirements for exemption from section 404 of the act. 108.19 Section 108.19 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION EMERGENCY PERMIT CONTROL General...

21 CFR 108.19 - Establishment of requirements for exemption from section 404 of the act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Establishment of requirements for exemption from section 404 of the act. 108.19 Section 108.19 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION EMERGENCY PERMIT CONTROL General...

34 CFR 222.161 - How is State aid treated under section 8009 of the Act?

Code of Federal Regulations, 2011 CFR

2011-07-01

... residing on Indian lands) or payments under section 8003(d) of the Act (children with disabilities... Indian lands). (D) Section 3(d)(3)(B)(ii) (increase for unusual geographical factors). (2) No State aid... definitions apply to this subpart: Current expenditures means the total charges incurred for the benefit of...

76 FR 41088 - Approval and Promulgation of Implementation Plans; Kentucky; 110(a)(1) and (2) Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

...EPA is taking final action to approve the December 13, 2007, submission by the Commonwealth of Kentucky, through the Kentucky Division of Air Quality (KDAQ) as demonstrating that the Commonwealth meets the state implementation plan (SIP) requirements of sections 110(a)(1) and (2) of the Clean Air Act (CAA or the Act) for the 1997 8- hour ozone national ambient air quality standards (NAAQS). Section 110(a) of the CAA requires that each state adopt and submit a SIP for the implementation, maintenance, and enforcement of each NAAQS promulgated by the EPA, which is commonly referred to as an ``infrastructure'' SIP. Kentucky certified that the Kentucky SIP contains provisions that ensure the 1997 8-hour ozone NAAQS is implemented, enforced, and maintained in Kentucky (hereafter referred to as ``infrastructure submission''). Kentucky's infrastructure submission, provided to EPA on December 13, 2007, addressed all the required infrastructure elements for the 1997 8-hour ozone NAAQS. Additionally, EPA is responding to adverse comments received on EPA's March 17, 2011, proposed approval of Kentucky's December 13, 2007, infrastructure submission.

76 FR 41100 - Approval and Promulgation of Implementation Plans; Alabama; 110(a)(1) and (2) Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

...EPA is taking final action to approve the December 10, 2007, submission by the State of Alabama, through the Alabama Department of Environmental Management (ADEM) as demonstrating that the State meets the state implementation plan (SIP) requirements of sections 110(a)(1) and (2) of the Clean Air Act (CAA or the Act) for the 1997 8-hour ozone national ambient air quality standards (NAAQS). Section 110(a) of the CAA requires that each state adopt and submit a SIP for the implementation, maintenance, and enforcement of each NAAQS promulgated by the EPA, which is commonly referred to as an ``infrastructure'' SIP. Alabama certified that the Alabama SIP contains provisions that ensure the 1997 8-hour ozone NAAQS is implemented, enforced, and maintained in Alabama (hereafter referred to as ``infrastructure submission''). Alabama's infrastructure submission, provided to EPA on December 10, 2007, addressed all the required infrastructure elements for the 1997 8-hour ozone NAAQS. Additionally, EPA is responding to adverse comments received on EPA's March 17, 2011, proposed approval of Alabama's December 10, 2007, infrastructure submission.

76 FR 41123 - Approval and Promulgation of Implementation Plans; Mississippi; 110(a)(1) and (2) Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

...EPA is taking final action to approve the December 7, 2007, submission by the State of Mississippi, through the Mississippi Department of Environmental Quality (MDEQ) as demonstrating that the State meets the implementation plan (SIP) requirements of sections 110(a)(1) and (2) of the Clean Air Act (CAA or the Act) for the 1997 8- hour ozone national ambient air quality standards (NAAQS). Section 110(a) of the CAA requires that each state adopt and submit a SIP for the implementation, maintenance, and enforcement of each NAAQS promulgated by the EPA, which is commonly referred to as an ``infrastructure'' SIP. Mississippi certified that the Mississippi SIP contains provisions that ensure the 1997 8-hour ozone NAAQS is implemented, enforced, and maintained in Mississippi (hereafter referred to as ``infrastructure submission''). Mississippi's infrastructure submission, provided to EPA on December 7, 2007, addressed all the required infrastructure elements for the 1997 8-hour ozone NAAQS. Additionally, EPA is responding to adverse comments received on EPA's March 17, 2011, proposed approval of Mississippi's December 7, 2007, infrastructure submission.

21 CFR 1210.27 - Permits waiving clauses 2 and 5, section 2 of the Federal Import Milk Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Federal Import Milk Act. 1210.27 Section 1210.27 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND DRUG ADMINISTRATION REGULATIONS UNDER THE FEDERAL IMPORT MILK ACT Permit Control § 1210.27...

21 CFR 1210.27 - Permits waiving clauses 2 and 5, section 2 of the Federal Import Milk Act.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Federal Import Milk Act. 1210.27 Section 1210.27 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND DRUG ADMINISTRATION REGULATIONS UNDER THE FEDERAL IMPORT MILK ACT Permit Control § 1210.27...

76 FR 68084 - Procedures for the Handling of Retaliation Complaints Under Section 806 of the Sarbanes-Oxley Act...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-03

... dealers; (ii) insurance companies; (iii) corporate issuers; (iv) issuers of asset-backed securities (as... ``whistleblower'') claims under section 806 of the Corporate and Criminal Fraud Accountability Act of 2002, Title... Systems Security Act and the Federal Railroad Safety Act, 29 CFR part 1982; the Consumer Product Safety...

2009 Strategic Plan for Autism Spectrum Disorder Research. NIH Publication No. 09-7465

ERIC Educational Resources Information Center

Interagency Autism Coordinating Committee, 2009

2009-01-01

In response to the heightened societal concern over autism spectrum disorder (ASD), Congress passed the Combating Autism Act (CAA) of 2006 (P.L. 109-416). Through this Act, Congress intended to rapidly increase, accelerate the pace and improve coordination of scientific discovery in ASD research. The CAA requires the Interagency Autism…

Grants for State and Interstate Agencies under Section 106 of the Clean Water Act

EPA Pesticide Factsheets

Each state and territory has established programs to protect and restore fresh waters, coastal waters and wetlands as outlined in the Clean Water Act. Section 106 grants support the implementation of those programs.

Public mental health crisis management and Section 136 of the Mental Health Act.

PubMed

O'Brien, Aileen; Sethi, Faisil; Smith, Mark; Bartlett, Annie

2018-05-01

The interface between mental health services and the criminal justice system presents challenges both for professionals and patients. Both systems are stressed and inherently complex. Section 136 of the Mental Health Act is unusual being both an aspect of the Mental Health Act and a power of arrest. It has a long and controversial history related to concerns about who has been detained and how the section was applied. More recently, Section 136 has had a public profile stemming from the use of police cells as places of safety for young, mentally disturbed individuals. This paper explores the current state of health of this piece of legislation. Specifically, we consider whether alternative approaches are more suitable for those individuals in crisis and/or distress who come into contact with the police. This requires careful thought as to the proper role of both health and criminal justice professionals who are daily grappling with an ethically contentious domain of multiagency work. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

77 FR 40106 - Notice of Applications for Deregistration Under Section 8(f) of the Investment Company Act of 1940

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-06

... Investment Management, Office of Investment Company Regulation, 100 F Street NE., Washington, DC 20549-8010... Deregistration Under Section 8(f) of the Investment Company Act of 1940 June 29, 2012. The following is a notice of applications for deregistration under section 8(f) of the Investment Company Act of 1940 for the...

76 FR 17971 - Notice of Applications for Deregistration Under Section 8(f) of the Investment Company Act of 1940

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-31

... Deregistration Under Section 8(f) of the Investment Company Act of 1940 March 25, 2011. The following is a notice of applications for deregistration under section 8(f) of the Investment Company Act of 1940 for the... Investment Management, Office of Investment Company Regulation, 100 F Street, NE., Washington, DC 20549-4041...

Improved sensitivity of the urine CAA lateral-flow assay for diagnosing active Schistosoma infections by using larger sample volumes.

PubMed

Corstjens, Paul L A M; Nyakundi, Ruth K; de Dood, Claudia J; Kariuki, Thomas M; Ochola, Elizabeth A; Karanja, Diana M S; Mwinzi, Pauline N M; van Dam, Govert J

2015-04-22

Accurate determination of Schistosoma infection rates in low endemic regions to examine progress towards interruption of transmission and elimination requires highly sensitive diagnostic tools. An existing lateral flow (LF) based test demonstrating ongoing infections through detection of worm circulating anodic antigen (CAA), was improved for sensitivity through implementation of a protocol allowing increased sample input. Urine is the preferred sample as collection is non-invasive and sample volume is generally not a restriction. Centrifugal filtration devices provided a method to concentrate supernatant of urine samples extracted with trichloroacetic acid (TCA). For field trials a practical sample volume of 2 mL urine allowed detection of CAA down to 0.3 pg/mL. The method was evaluated on a set of urine samples (n = 113) from an S. mansoni endemic region (Kisumu, Kenya) and compared to stool microscopy (Kato Katz, KK). In this analysis true positivity was defined as a sample with either a positive KK or UCAA test. Implementation of the concentration method increased clinical sensitivity (Sn) from 44 to 98% when moving from the standard 10 μL (UCAA10 assay) to 2000 μL (UCAA2000 assay) urine sample input. Sn for KK varied between 23 and 35% for a duplicate KK (single stool, two slides) to 52% for a six-fold KK (three consecutive day stools, two slides). The UCAA2000 assay indicated 47 positive samples with CAA concentration above 0.3 pg/mL. The six-fold KK detected 25 egg positives; 1 sample with 2 eggs detected in the 6-fold KK was not identified with the UCAA2000 assay. Larger sample input increased Sn of the UCAA assay to a level indicating 'true' infection. Only a single 2 mL urine sample is needed, but analysing larger sample volumes could still increase test accuracy. The UCAA2000 test is an appropriate candidate for accurate identification of all infected individuals in low-endemic regions. Assay materials do not require refrigeration and collected

Levels of H-ras codon 61 CAA to AAA mutation: response to 4-ABP-treatment and Pms2-deficiency.

PubMed

Parsons, Barbara L; Delongchamp, Robert R; Beland, Frederick A; Heflich, Robert H

2006-01-01

DNA mismatch repair (MMR) deficiencies result in increased frequencies of spontaneous mutation and tumor formation. In the present study, we tested the hypothesis that a chemically-induced mutational response would be greater in a mouse with an MMR-deficiency than in the MMR-proficient mouse models commonly used to assay for chemical carcinogenicity. To accomplish this, the induction of H-ras codon 61 CAA-->AAA mutation was examined in Pms2 knockout mice (Pms2-/-, C57BL/6 background) and sibling wild-type mice (Pms2+/+). Groups of five or six neonatal male mice were treated with 0.3 micromol 4-aminobiphenyl (4-ABP) or the vehicle control, dimethylsulfoxide. Eight months after treatment, liver DNAs were isolated and analysed for levels of H-ras codon 61 CAA-->AAA mutation using allele-specific competitive blocker-PCR. In Pms2-proficient and Pms2-deficient mice, 4-ABP treatment caused an increase in mutant fraction (MF) from 1.65x10(-5) to 2.91x10(-5) and from 3.40x10(-5) to 4.70x10(-5), respectively. Pooling data from 4-ABP-treated and control mice, the approximately 2-fold increase in MF observed in Pms2-deficient as compared with Pms2-proficient mice was statistically significant (P=0.0207) and consistent with what has been reported previously in terms of induction of G:C-->T:A mutation in a Pms2-deficient background. Pooling data from both genotypes, the increase in H-ras MF in 4-ABP-treated mice, as compared with control mice, did not reach the 95% confidence level of statistical significance (P=0.0606). The 4-ABP treatment caused a 1.76-fold and 1.38-fold increase in average H-ras MF in Pms2-proficient and Pms2-deficient mice, respectively. Furthermore, the levels of induced mutation in Pms2-proficient and Pms2-deficient mice were nearly identical (1.26x10(-5) and 1.30x10(-5), respectively). We conclude that Pms2-deficiency does not result in an amplification of the H-ras codon 61 CAA-->AAA mutational response induced by 4-ABP.

Anomalies of Section 2 of the Homicide Act 1957.

PubMed Central

Kenny, A

1986-01-01

Section 2 of the 1957 Homicide Act is indefensible: the concept of 'mental responsibility' is a hybrid which turns the psychiatrist witness either into a thirteenth juryman or a spare barrister. But reform does not lie along the lines suggested by the Butler Committee or the Criminal Law Revision Committee. The latter leaves the jury with insufficient guidance; the former returns to the bad eighteenth century policy of treating mental illness not as a factor in determining responsibility but as a status exempting from responsibility. The much criticised McNaughton rules provide a sounder basis for deciding where responsibility should be assigned in criminal cases. PMID:3959036

Virginia Department of Transportation compliance with Section 106 of the National Historic Preservation Act.

DOT National Transportation Integrated Search

1988-01-01

Whenever a highway construction project is federally assisted, Section 106 of the National Historic Preservation Act, in effect, requires the Virginia Department of Transportation (VDOT) to locate and evaluate historic and prehistoric properties with...

21 CFR 70.50 - Application of the cancer clause of section 721 of the act.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Application of the cancer clause of section 721 of the act. 70.50 Section 70.50 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... testing) suggest the possibility that the color additive including its components or impurities has...

21 CFR 70.50 - Application of the cancer clause of section 721 of the act.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Application of the cancer clause of section 721 of the act. 70.50 Section 70.50 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... testing) suggest the possibility that the color additive including its components or impurities has...

21 CFR 70.50 - Application of the cancer clause of section 721 of the act.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Application of the cancer clause of section 721 of the act. 70.50 Section 70.50 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... testing) suggest the possibility that the color additive including its components or impurities has...

75 FR 8760 - Order Granting Application for Exemption Pursuant to Section 36(a) of the Exchange Act by BATS...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-61534] Order Granting Application for Exemption Pursuant to Section 36(a) of the Exchange Act by BATS Exchange, Inc. From the Rule Filing Requirements of Section 19(b) of the Exchange Act With Respect to Certain Rules Incorporated by Reference February 18, 2010. BATS Exchange, Inc. (``BATS...

Cerebral amyloid angiopathy initially occurs in the meningeal vessels.

PubMed

Takeda, Shigeki; Yamazaki, Kazunori; Miyakawa, Teruo; Onda, Kiyoshi

2017-12-01

To clarify the frequency of CAA in the brain parenchyma and subarachnoid space (SAS), we counted sections of blood vessels showing positive staining for Aβ in the SAS, cerebral cortex (CC) and cerebral white matter (WM) using paraffin-embedded sections of the frontal, temporal and occipital lobes. The specimens had been taken for routine neuropathological examination from the brains of 105 Japanese patients (aged 40-95 years) selected from among 200 consecutive patients autopsied between 1989 and 2015 at our hospital. We examined the anatomical ratios of blood-vessel sections in the SAS relative to the CC in three selected CAA cases, and those of Aβ-positive blood-vessel sections in CAA cases. CAA was found in 53 of the 105 cases (50.5%), and the youngest patient affected was a 51-year-old man. The incidence of CAA increased with age. The anatomical ratio of blood vessel sections in the SAS relative to the CC was 1/3.70-1/4.37 (mean: 1/3.94). The ordinary CAA group, in which CAA was seen in both the SAS and CC, included 41 cases (77.4%). In 37 of these cases, the SAS/CC ratio of Aβ-positive blood vessels was 1/0.05-1/0.66 (mean: 1/0.26), and in the other four cases the ratio was 1/1-1/1.5. In the ordinary CAA group, the SAS/CC ratio of Aβ-positive blood vessels was smaller than the anatomical ratio. The meningeal CAA group, in which CAA was found only in the SAS, included 12 cases (22.6%). These patients ranged in age from their fifties to their nineties. There was no case in which CAA was limited only to the CC. We concluded that CAA initially develops in the meningeal blood vessels, and not in the cortical blood vessels. CAA in the WM was seen in 10 cases, not only in nine cases that were severe, but also in a mild case. © 2017 Japanese Society of Neuropathology.

Procedures for the Handling of Retaliation Complaints Under Section 1558 of the Affordable Care Act. Final rule.

PubMed

2016-10-13

This document provides the final text of regulations governing employee protection (retaliation or whistleblower) claims under section 1558 of the Affordable Care Act, which added section 18C to the Fair Labor Standards Act to provide protections to employees who may have been subject to retaliation for seeking assistance under certain affordability assistance provisions (for example, health insurance premium tax credits) or for reporting potential violations of the Affordable Care Act's consumer protections (for example, the prohibition on rescissions). An interim final rule (IFR) governing these provisions and request for comments was published in the Federal Register on February 27, 2013. Thirteen comments were received; eleven were responsive to the IFR. This rule responds to those comments and establishes the final procedures and time frames for the handling of retaliation complaints under section 18C, including procedures and time frames for employee complaints to the Occupational Safety and Health Administration (OSHA), investigations by OSHA, appeals of OSHA determinations to an administrative law judge (ALJ) for a hearing de novo, hearings by ALJs, review of ALJ decisions by the Administrative Review Board (ARB) (acting on behalf of the Secretary of Labor), and judicial review of the Secretary of Labor's (Secretary's) final decision. It also sets forth the Secretary's interpretations of the Affordable Care Act whistleblower provision on certain matters.

75 FR 43797 - Delegation of Certain Functions Under Section 1264 of the Victims of Iranian Censorship Act...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-26

... Certain Functions Under Section 1264 of the Victims of Iranian Censorship Act (Public Law 111-84, Subtitle... State, the functions conferred upon the President by section 1264 of the Victims of Iranian Censorship...

17 CFR 270.14a-2 - Exemption from section 14(a) of the Act for certain registered separate accounts and their...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exemption from section 14(a... Section 270.14a-2 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) RULES AND REGULATIONS, INVESTMENT COMPANY ACT OF 1940 § 270.14a-2 Exemption from section 14(a) of the Act...

47 CFR 51.807 - Arbitration and mediation of agreements by the Commission pursuant to section 252(e)(5) of the Act.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Arbitration and mediation of agreements by the Commission pursuant to section 252(e)(5) of the Act. 51.807 Section 51.807 Telecommunication FEDERAL... Implementation of Section 252 of the Act § 51.807 Arbitration and mediation of agreements by the Commission...

3 CFR - Presidential Determination Under Section 402 (c)(2)(A) of the Trade Act of 1974-Republic of Belarus

Code of Federal Regulations, 2010 CFR

2010-01-01

... 3 The President 1 2010-01-01 2010-01-01 false Presidential Determination Under Section 402 (c)(2)(A) of the Trade Act of 1974-Republic of Belarus Presidential Documents Other Presidential Documents Presidential Determination No. 2009-22 of July 1, 2009 Presidential Determination Under Section 402 (c)(2)(A) of the Trade Act of 1974—Republic of...

75 FR 49435 - Transportation Conformity Rule Restructuring Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-13

... transportation plans, programs, or projects under title 23 U.S.C. or title 49 U.S.C. chapter 53. Regulated... for copying docket materials. C. How do I get copies of this proposed rule and other documents? 1... Clean Air Act (CAA) section 176(c) (42 U.S.C. 7506(c)) to ensure that transportation plans...

Ifosfamide metabolites CAA, 4-OH-Ifo and Ifo-mustard reduce apical phosphate transport by changing NaPi-IIa in OK cells.

PubMed

Patzer, L; Hernando, N; Ziegler, U; Beck-Schimmer, B; Biber, J; Murer, H

2006-11-01

Renal Fanconi syndrome occurs in about 1-5% of all children treated with Ifosfamide (Ifo) and impairment of renal phosphate reabsorption in about 20-30% of them. Pathophysiological mechanisms of Ifo-induced nephropathy are ill defined. The aim has been to investigate whether Ifo metabolites affect the type IIa sodium-dependent phosphate transporter (NaPi-IIa) in viable opossum kidney cells. Ifo did not influence viability of cells or NaPi-IIa-mediated transport up to 1 mM/24 h. Incubation of confluent cells with chloroacetaldehyde (CAA) and 4-hydroperoxyIfosfamide (4-OH-Ifo) led to cell death by necrosis in a concentration-dependent manner. At low concentrations (50-100 microM/24 h), cell viability was normal but apical phosphate transport, NaPi-IIa protein, and -mRNA expression were significantly reduced. Coincubation with sodium-2-mercaptoethanesulfonate (MESNA) prevented the inhibitory action of CAA but not of 4-OH-Ifo; DiMESNA had no effect. Incubation with Ifosfamide-mustard (Ifo-mustard) did alter cell viability at concentrations above 500 microM/24 h. At lower concentrations (50-100 microM/24 h), it led to significant reduction in phosphate transport, NaPi-IIa protein, and mRNA expression. MESNA did not block these effects. The effect of Ifo-mustard was due to internalization of NaPi-IIa. Cyclophosphamide-mustard (CyP-mustard) did not have any influence on cell survival up to 1000 microM, but the inhibitory effect on phosphate transport and on NaPi-IIa protein was the same as found after Ifo-mustard. In conclusion, CAA, 4-OH-Ifo, and Ifo- and CyP-mustard are able to inhibit sodium-dependent phosphate cotransport in viable opossum kidney cells. The Ifo-mustard effect took place via internalization and reduction of de novo synthesis of NaPi-IIa. Therefore, it is possible that Ifo-mustard plays an important role in pathogenesis of Ifo-induced nephropathy.

21 CFR 571.115 - Application of the cancer clause of section 409 of the act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Application of the cancer clause of section 409 of... Administrative Actions on Applications § 571.115 Application of the cancer clause of section 409 of the act. Food... cancer to people must satisfy the requirements of subpart E of part 500 of this chapter. [52 FR 49588...

21 CFR 571.115 - Application of the cancer clause of section 409 of the act.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Application of the cancer clause of section 409 of... Administrative Actions on Applications § 571.115 Application of the cancer clause of section 409 of the act. Food... cancer to people must satisfy the requirements of subpart E of part 500 of this chapter. [52 FR 49588...

21 CFR 571.115 - Application of the cancer clause of section 409 of the act.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Application of the cancer clause of section 409 of... Administrative Actions on Applications § 571.115 Application of the cancer clause of section 409 of the act. Food... cancer to people must satisfy the requirements of subpart E of part 500 of this chapter. [52 FR 49588...

21 CFR 571.115 - Application of the cancer clause of section 409 of the act.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Application of the cancer clause of section 409 of... Administrative Actions on Applications § 571.115 Application of the cancer clause of section 409 of the act. Food... cancer to people must satisfy the requirements of subpart E of part 500 of this chapter. [52 FR 49588...

21 CFR 571.115 - Application of the cancer clause of section 409 of the act.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 6 2012-04-01 2012-04-01 false Application of the cancer clause of section 409 of... Administrative Actions on Applications § 571.115 Application of the cancer clause of section 409 of the act. Food... cancer to people must satisfy the requirements of subpart E of part 500 of this chapter. [52 FR 49588...

19 CFR 351.218 - Sunset reviews under section 751(c) of the Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

.... 351.218 Section 351.218 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE... the Act and § 351.203(e)(4), the Secretary may decline the request for early initiation. (4... (E) The citation and date of publication in the Federal Register of the notice of initiation. (iii...

Detection of Hb Constant Spring [α142, Term→Gln, TAA>CAA (α2)] in heterozygotes combined with β-thalassemia.

PubMed

Li, You-Qiong; Li, Ru; Li, Dong-Zhi

2013-01-01

Hb Constant Spring [Hb CS, α142, Term→Gln, TAA>CAA (α2)] is a nondeletional form of α-thalassemia (α-thal) that is most prevalent in Southern Chinese and Southeast Asian populations. We previously found that Hb CS trait could efficiently be screened using Sebia Capillarys2. In this study, we report that Hb CS heterozygotes combined with β-thal could not be detected by the Sebia Capillarys2 method due to the very small amount of Hb CS.

76 FR 55577 - Findings of Failure To Submit a Complete State Implementation Plan for Section 110(a) Pertaining...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-08

... Failure To Submit a Complete State Implementation Plan for Section 110(a) Pertaining to the 2006 Fine... submission for some or all of these specific requirements. The finding of failure to submit for some or all... making a finding of failure to submit SIPs, or elements of SIPs, required by the CAA, where states have...

17 CFR 270.18f-1 - Exemption from certain requirements of section 18(f)(1) (of the Act) for registered open-end...

Code of Federal Regulations, 2010 CFR

2010-04-01

... requirements of section 18(f)(1) (of the Act) for registered open-end investment companies which have the right... EXCHANGE COMMISSION (CONTINUED) RULES AND REGULATIONS, INVESTMENT COMPANY ACT OF 1940 § 270.18f-1 Exemption from certain requirements of section 18(f)(1) (of the Act) for registered open-end investment companies...

Health Careers Opportunity Program (HCOP). Section 787 (Public Health Service Act). Program Guide.

ERIC Educational Resources Information Center

Department of Health and Human Services, Washington, DC.

This document summarizes the requirements and guidelines for the Health Careers Opportunity Program (HCOP). This program is authorized by Section 787 of the Public Health Service Act to make grants to and contracts with postsecondary institutions to carry out programs which assist individuals from disadvantaged backgrounds to enter and graduate…

76 FR 62061 - Clean Water Act Section 303(d): Availability of List Decisions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-06

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9475-4] Clean Water Act Section 303(d): Availability of List... three waterbodies. These three waterbodies were added by EPA because the applicable numeric water... be obtained at EPA Region 6's Web site at http://www.epa.gov/region6/water/npdes/tmdl/index.htm...

77 FR 74129 - Approval and Promulgation of Implementation Plans; Texas; Public Participation for Air Quality...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-13

...EPA is proposing to approve revisions to the Texas State Implementation Plan (SIP) that establish the public participation requirements for air quality permits. EPA proposes to find that these revisions to the Texas SIP comply with the Federal Clean Air Act (the Act or CAA) and EPA regulations and are consistent with EPA policies. Texas submitted the public participation provisions in four separate revisions to the SIP on July 22, 1998; October 25, 1999; July 2, 2010; and March 11, 2011. EPA is proposing this action under section 110 and parts C and D of the Clean Air Act (the Act).

12 CFR 225.104 - “Services” under section 4(c)(1) of Bank Holding Company Act.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Holding Company Act. 225.104 Section 225.104 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.104 “Services” under section 4(c)(1) of Bank...

12 CFR 225.109 - “Services” under section 4(c)(1) of Bank Holding Company Act.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Holding Company Act. 225.109 Section 225.109 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.109 “Services” under section 4(c)(1) of Bank...

19 CFR 162.73a - Penalties under section 593A, Tariff Act of 1930, as amended.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Penalties under section 593A, Tariff Act of 1930, as amended. 162.73a Section 162.73a Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) INSPECTION, SEARCH, AND SEIZURE Special...

76 FR 10527 - Regulatory Flexibility Act: Section 610 Review of National Organic Program Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-25

...: This document announces the Agricultural Marketing Service's (AMS) plans to review the National Organic... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 205 [Document Number AMS-NOP-11-0005; NOP-11-01] Regulatory Flexibility Act: Section 610 Review of National Organic Program...

29 CFR 785.5 - General requirements of sections 6 and 7 of the Fair Labor Standards Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false General requirements of sections 6 and 7 of the Fair Labor... WORKED Principles for Determination of Hours Worked § 785.5 General requirements of sections 6 and 7 of the Fair Labor Standards Act. Section 6 requires the payment of a minimum wage by an employer to his...

The fifth electron in the fully reduced caa(3) from Thermus thermophilus is competent in proton pumping.

PubMed

Siletsky, Sergey A; Belevich, Ilya; Soulimane, Tewfik; Verkhovsky, Michael I; Wikström, Mårten

2013-01-01

The time-resolved kinetics of membrane potential generation coupled to oxidation of the fully reduced (five-electron) caa(3) cytochrome oxidase from Thermus thermophilus by oxygen was studied in a single-turnover regime. In order to calibrate the number of charges that move across the vesicle membrane in the different reaction steps, the reverse electron transfer from heme a(3) to heme a and further to the cytochrome c/Cu(A) has been resolved upon photodissociation of CO from the mixed valence enzyme in the absence of oxygen. The reverse electron transfer from heme a(3) to heme a and further to the cytochrome c/Cu(A) pair is resolved as a single transition with τ~40 μs. In the reaction of the fully reduced cytochrome caa(3) with oxygen, the first electrogenic phase (τ~30 μs) is linked to OO bond cleavage and generation of the P(R) state. The next electrogenic component (τ~50 μs) is associated with the P(R)→F transition and together with the previous reaction step it is coupled to translocation of about two charges across the membrane. The three subsequent electrogenic phases, with time constants of ~0.25 ms, ~1.4 ms and ~4 ms, are linked to the conversion of the binuclear center through the F→O(H)→E(H) transitions, and result in additional transfer of four charges through the membrane dielectric. This indicates that the delivery of the fifth electron from heme c to the binuclear center is coupled to pumping of an additional proton across the membrane. Copyright © 2012 Elsevier B.V. All rights reserved.

2 CFR 176.190 - Award term-Wage rate requirements under Section 1606 of the Recovery Act.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Award term-Wage rate requirements under Section 1606 of the Recovery Act. 176.190 Section 176.190 Grants and Agreements OFFICE OF MANAGEMENT AND... are in excess of $2,000 for construction, alteration or repair (including painting and decorating). (b...

Characterization of the complete mitochondrial genome of the Grey-backed Shrike, Lanius tephronotus (Aves: Passeriformes): the first representative of the family Laniidae with a novel CAA stop codon at the end of cox2 gene.

PubMed

Qian, Chaoju; Yan, Xia; Guo, Zhichun; Wang, Yuanxiu; Li, Xixi; Yang, Jianke; Kan, Xianzhao

2013-08-01

The complete Grey-backed Shrike mitochondrial genome has been sequenced to be 16,820 bp in length, consisting of 37 encode genes: 13 protein-coding genes, 2 ribosomal RNA genes, and 22 transfer RNA genes. In addition, a single control region was also observed. Compared with other reported Passeriformes mtgenome sequences, three bases CAA were detected at the end of Lanius tephronotus cox2 gene with the downstream adjacent base T. The first base of CAA probably occurred C to U transcript editing event resulting in a normal stop codon UAA.

48 CFR 970.5226-2 - Workforce restructuring under section 3161 of the National Defense Authorization Act for fiscal...

Code of Federal Regulations, 2010 CFR

2010-10-01

... a change in workforce at a Department of Energy Defense Nuclear Facility is necessary, the... under section 3161 of the National Defense Authorization Act for fiscal year 1993. 970.5226-2 Section... and Operating Contracts 970.5226-2 Workforce restructuring under section 3161 of the National Defense...

26 CFR 1.269-7 - Relationship of section 269 to sections 382 and 383 after the Tax Reform Act of 1986.

Code of Federal Regulations, 2011 CFR

2011-04-01

... the principal purpose of an acquisition is the evasion or avoidance of Federal income tax. [T.D. 8388... 383 after the Tax Reform Act of 1986. 1.269-7 Section 1.269-7 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Items Not...

26 CFR 1.269-7 - Relationship of section 269 to sections 382 and 383 after the Tax Reform Act of 1986.

Code of Federal Regulations, 2010 CFR

2010-04-01

... the principal purpose of an acquisition is the evasion or avoidance of Federal income tax. [T.D. 8388... 383 after the Tax Reform Act of 1986. 1.269-7 Section 1.269-7 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Items Not Deductible...

19 CFR 205.6 - Investigations under section 301(e)(3) of the Trade Act of 1974.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 3 2011-04-01 2011-04-01 false Investigations under section 301(e)(3) of the Trade Act of 1974. 205.6 Section 205.6 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS TO DETERMINE THE PROBABLE ECONOMIC EFFECT ON THE ECONOMY OF THE UNITED STATES OF PROPOSED MODIFICATIONS OF...

19 CFR 205.6 - Investigations under section 301(e)(3) of the Trade Act of 1974.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Investigations under section 301(e)(3) of the Trade Act of 1974. 205.6 Section 205.6 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS TO DETERMINE THE PROBABLE ECONOMIC EFFECT ON THE ECONOMY OF THE UNITED STATES OF PROPOSED MODIFICATIONS OF...

Clean Water Act Section 404 and Agriculture

EPA Pesticide Factsheets

The U.S. Department of Agriculture (USDA) and EPA have longstanding programs to promote water quality and broader environmental goals identified in both the Agriculture Act of 2014 and the Clean Water Act.

48 CFR 970.5226-2 - Workforce restructuring under section 3161 of the National Defense Authorization Act for fiscal...

Code of Federal Regulations, 2014 CFR

2014-10-01

... workforce at a Department of Energy Defense Nuclear Facility is necessary, the contractor agrees to (1... under section 3161 of the National Defense Authorization Act for fiscal year 1993. 970.5226-2 Section... and Operating Contracts 970.5226-2 Workforce restructuring under section 3161 of the National Defense...

48 CFR 970.5226-2 - Workforce restructuring under section 3161 of the National Defense Authorization Act for fiscal...

Code of Federal Regulations, 2011 CFR

2011-10-01

... workforce at a Department of Energy Defense Nuclear Facility is necessary, the contractor agrees to (1... under section 3161 of the National Defense Authorization Act for fiscal year 1993. 970.5226-2 Section... and Operating Contracts 970.5226-2 Workforce restructuring under section 3161 of the National Defense...

48 CFR 970.5226-2 - Workforce restructuring under section 3161 of the National Defense Authorization Act for fiscal...

Code of Federal Regulations, 2012 CFR

2012-10-01

... workforce at a Department of Energy Defense Nuclear Facility is necessary, the contractor agrees to (1... under section 3161 of the National Defense Authorization Act for fiscal year 1993. 970.5226-2 Section... and Operating Contracts 970.5226-2 Workforce restructuring under section 3161 of the National Defense...

48 CFR 970.5226-2 - Workforce restructuring under section 3161 of the National Defense Authorization Act for fiscal...

Code of Federal Regulations, 2013 CFR

2013-10-01

... workforce at a Department of Energy Defense Nuclear Facility is necessary, the contractor agrees to (1... under section 3161 of the National Defense Authorization Act for fiscal year 1993. 970.5226-2 Section... and Operating Contracts 970.5226-2 Workforce restructuring under section 3161 of the National Defense...

5 CFR 1315.20 - Application of Section 1010 of the National Defense Authorization Act for Fiscal Year 2001.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Application of Section 1010 of the National Defense Authorization Act for Fiscal Year 2001. 1315.20 Section 1315.20 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES PROMPT PAYMENT § 1315.20 Application of Section 1010 of...

MR imaging detection of cerebral microbleeds: effect of susceptibility-weighted imaging, section thickness, and field strength.

PubMed

Nandigam, R N K; Viswanathan, A; Delgado, P; Skehan, M E; Smith, E E; Rosand, J; Greenberg, S M; Dickerson, B C

2009-02-01

The emergence of cerebral microbleeds (CMB) as common MR imaging findings raises the question of how MR imaging parameters influence CMB detection. To evaluate the effects of modified gradient recalled-echo (GRE) MR imaging methods, we performed an analysis of sequence, section thickness, and field strength on CMB imaging properties and detection in subjects with cerebral amyloid angiopathy (CAA), a condition associated with microhemorrhage. Multiple MR images were obtained from subjects with probable CAA, with varying sequences (GRE versus susceptibility-weighted imaging [SWI]), section thicknesses (1.2-1.5 versus 5 mm), and magnetic field strengths (1.5T versus 3T). Individual CMB were manually identified and analyzed for contrast index (lesion intensity normalized to normal-appearing white matter signal intensity) and diameter. CMB counts were compared between 1.5T thick-section GRE and thin-section SWI for 3 subjects who underwent both protocols in the same scanning session. With other parameters constant, use of SWI, thinner sections, and a higher field strength yielded medium-to-large gains in CMB contrast index (CI; Cohen d 0.71-1.87). SWI was also associated with small increases in CMB diameter (Cohen d <0.3). Conventional thick-section GRE identified only 33% of CMB (103 of 310) seen on thin-section SWI. Lesions prospectively identified on GRE had significantly greater CI and diameter measured on the GRE image than those not prospectively identified. The examined alternatives to conventional GRE MR imaging yield substantially improved CMB contrast and sensitivity for detection. Future studies based on these techniques will most likely yield even higher prevalence estimates for CMB.

MR Imaging Detection of Cerebral Microbleeds: Effect of Susceptibility-Weighted Imaging, Section Thickness, and Field Strength

PubMed Central

Nandigam, R.N.K.; Viswanathan, A.; Delgado, P.; Skehan, M.E.; Smith, E.E.; Rosand, J.; Greenberg, S.M.; Dickerson, B.C.

2009-01-01

BACKGROUND AND PURPOSE: The emergence of cerebral microbleeds (CMB) as common MR imaging findings raises the question of how MR imaging parameters influence CMB detection. To evaluate the effects of modified gradient recalled-echo (GRE) MR imaging methods, we performed an analysis of sequence, section thickness, and field strength on CMB imaging properties and detection in subjects with cerebral amyloid angiopathy (CAA), a condition associated with microhemorrhage. MATERIALS AND METHODS: Multiple MR images were obtained from subjects with probable CAA, with varying sequences (GRE versus susceptibility-weighted imaging [SWI]), section thicknesses (1.2–1.5 versus 5 mm), and magnetic field strengths (1.5T versus 3T). Individual CMB were manually identified and analyzed for contrast index (lesion intensity normalized to normal-appearing white matter signal intensity) and diameter. CMB counts were compared between 1.5T thick-section GRE and thin-section SWI for 3 subjects who underwent both protocols in the same scanning session. RESULTS: With other parameters constant, use of SWI, thinner sections, and a higher field strength yielded medium-to-large gains in CMB contrast index (CI; Cohen d 0.71–1.87). SWI was also associated with small increases in CMB diameter (Cohen d <0.3). Conventional thick-section GRE identified only 33% of CMB (103 of 310) seen on thin-section SWI. Lesions prospectively identified on GRE had significantly greater CI and diameter measured on the GRE image than those not prospectively identified. CONCLUSIONS: The examined alternatives to conventional GRE MR imaging yield substantially improved CMB contrast and sensitivity for detection. Future studies based on these techniques will most likely yield even higher prevalence estimates for CMB. PMID:19001544

Understanding and Implementing Section 2141(c) of the Elementary and Secondary Education Act. Policy-to-Practice Brief

ERIC Educational Resources Information Center

Potemski, Amy

2009-01-01

According to Section 2141(c) of the Elementary and Secondary Education Act (ESEA), as reauthorized by the No Child Left Behind Act (NCLB), local education agencies (LEAs) that fail to meet annual measurable objectives and make adequate yearly progress (AYP) for three consecutive years must enter into an agreement with the state education agency…

75 FR 71431 - Clean Water Act Section 303(d): Availability of List Decisions Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-23

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9230-1] Clean Water Act Section 303(d): Availability of List... Availability. SUMMARY: This action corrects a Federal Register notice that published on November 9, 2010 at 75 FR 68783 announcing the availability of EPA decisions identifying water quality limited segments and...

78 FR 54484 - Notice of Lodging of Consent Decree Under the Clean Air Act (CAA)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-04

... and the People of the State of California ex rel. California Air Resources Board v. MotorScience Enterprises, Inc., MotorScience, Inc. and Chi Zheng, C.A. No. 1:11-cv-08023 GHK was lodged with the United... Safety Code section 43151, the Plaintiffs sought injunctive relief against the Defendants MotorScience...

Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) or Superfund, Section 104(k); and CERCLA Section 104(d); ‘‘ ‘Discounted Loans’ Under Brownfields Revolving Loan Fund Grants’

EPA Pesticide Factsheets

Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) or Superfund, Section 104(k); and CERCLA Section 104(d); ‘‘ ‘Discounted Loans’ Under Brownfields Revolving Loan Fund Grants’`

2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Award term-Reporting and registration requirements under section 1512 of the Recovery Act. 176.50 Section 176.50 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE...

2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Award term-Reporting and registration requirements under section 1512 of the Recovery Act. 176.50 Section 176.50 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE...

2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Award term-Reporting and registration requirements under section 1512 of the Recovery Act. 176.50 Section 176.50 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE...

2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Award term-Reporting and registration requirements under section 1512 of the Recovery Act. 176.50 Section 176.50 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE...

76 FR 41111 - Approval and Promulgation of Implementation Plans; South Carolina; 110(a)(1) and (2...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

...EPA is taking final action to approve the December 13, 2007, submission submitted by the State of South Carolina, through the South Carolina Department of Health and Environmental Control (SC DHEC) as demonstrating that the State meets the state implementation plan (SIP) requirements of sections 110(a)(1) and (2) of the Clean Air Act (CAA or the Act) for the 1997 8-hour ozone national ambient air quality standards (NAAQS). Section 110(a) of the CAA requires that each state adopt and submit a SIP for the implementation, maintenance, and enforcement of each NAAQS promulgated by the EPA, which is commonly referred to as an ``infrastructure'' SIP. South Carolina certified that the South Carolina SIP contains provisions that ensure the 1997 8-hour ozone NAAQS is implemented, enforced, and maintained in South Carolina (hereafter referred to as ``infrastructure submission''). South Carolina's infrastructure submission, provided to EPA on December 13, 2007, addressed all the required infrastructure elements for the 1997 8-hour ozone NAAQS. Additionally, EPA is correcting an inadvertent error and responding to adverse comments received on EPA's March 17, 2011, proposed approval of South Carolina's December 13, 2007, infrastructure submission.

Structural insights into electron transfer in caa3-type cytochrome oxidase

PubMed Central

Lyons, Joseph A.; Aragão, David; Slattery, Orla; Pisliakov, Andrei V.; Soulimane, Tewfik; Caffrey, Martin

2012-01-01

Summary Paragraph Cytochrome c oxidase is a member of the heme copper oxidase superfamily (HCO)1. HCOs function as the terminal enzymes in the respiratory chain of mitochondria and aerobic prokaryotes, coupling molecular oxygen reduction to transmembrane proton pumping. Integral to the enzyme’s function is the transfer of electrons from cytochrome c to the oxidase via a transient association of the two proteins. Electron entry and exit are proposed to occur from the same site on cytochrome c2–4. Here we report the crystal structure of the caa3-type cytochrome oxidase from Thermus thermophilus, which has a covalently tethered cytochrome c domain. Crystals were grown in a bicontinuous mesophase using a synthetic short-chain monoacylglycerol as the hosting lipid. From the electron density map, at 2.36 Å resolution, a novel integral membrane subunit and a native glycoglycerophospholipid embedded in the complex were identified. Contrary to previous electron transfer mechanisms observed for soluble cytochrome c, the structure reveals the architecture of the electron transfer complex for the fused cupredoxin/cytochrome c domain which implicates different sites on cytochrome c for electron entry and exit. Support for an alternative to the classical proton gate characteristic of this HCO class is presented. PMID:22763450

Section Five of the Voting Rights Act and Its Effects upon Southern School Boards.

ERIC Educational Resources Information Center

Foster, Lorn S.

1984-01-01

Examined differences in amount of Black representation on Southern school boards when one or more objections to electoral district changes have been filed by the Department of Justice (DOJ) under Section Five of the Voting Rights Act. Found that demographic and social data do not explain DOJ objections filed against the boards. (CJM)

17 CFR 230.133 - Definition for purposes of section 5 of the Act, of “sale”, “offer”, “offer to sell”, and “offer...

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Definition for purposes of section 5 of the Act, of âsaleâ, âofferâ, âoffer to sellâ, and âoffer for saleâ. 230.133 Section 230.133..., SECURITIES ACT OF 1933 General § 230.133 Definition for purposes of section 5 of the Act, of “sale”, “offer...

17 CFR 230.133 - Definition for purposes of section 5 of the Act, of “sale”, “offer”, “offer to sell”, and “offer...

Code of Federal Regulations, 2012 CFR

2012-04-01

... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false Definition for purposes of section 5 of the Act, of âsaleâ, âofferâ, âoffer to sellâ, and âoffer for saleâ. 230.133 Section 230.133..., SECURITIES ACT OF 1933 General § 230.133 Definition for purposes of section 5 of the Act, of “sale”, “offer...

75 FR 68395 - Agency Self-Evaluation Under Section 504 of the Rehabilitation Act of 1973

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-05

...-800-325- 0778, or visit our Internet site, Social Security Online, at http://www.socialsecurity.gov... SOCIAL SECURITY ADMINISTRATION [Docket No. SSA-2010-0069] Agency Self-Evaluation Under Section 504 of the Rehabilitation Act of 1973 AGENCY: Social Security Administration. ACTION: Notice and request...

77 FR 37091 - Determination Under Section 620(q) of the Foreign Assistance Act of 1961, as Amended, Relating to...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-20

... DEPARTMENT OF STATE [Public Notice 7926] Determination Under Section 620(q) of the Foreign... vested in me by section 620(q) of the Foreign Assistance Act of 1961, as amended (FAA), Executive Order... waive the application of section 620(q) of the FAA for such assistance. This Determination shall be...

3 CFR - Annual Update to the Report Specified in Section 1251 of the National Defense Authorization Act...

Code of Federal Regulations, 2012 CFR

2012-01-01

... 3 The President 1 2012-01-01 2012-01-01 false Annual Update to the Report Specified in Section 1251 of the National Defense Authorization Act for Fiscal Year 2010 (Public Law 111-84) Presidential Documents Other Presidential Documents Memorandum of February 7, 2011 Annual Update to the Report Specified in Section 1251 of the National Defense...

76 FR 24187 - Electricity Market Transparency Provisions of Section 220 of the Federal Power Act

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-29

... section 1281 of the Energy Policy Act of 2005 (EPAct 2005), to facilitate price transparency in markets... availability and prices of wholesale electric energy and transmission service to the Commission, State... 220 to ``facilitate price transparency in the markets for the sale and transmission of electric energy...

76 FR 20434 - Determination Under Section 602(q) of the Foreign Assistance Act of 1961, as Amended, Relating to...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-12

... DEPARTMENT OF STATE [Public Notice 7412] Determination Under Section 602(q) of the Foreign... vested in me by Section 620(q) of the Foreign Assistance Act of 1961, as amended (FAA), Executive Order... national interest of the United States and thereby waive the application of section 620(q) of the FAA for...

19 CFR 206.44a - Special rules for conducting investigations under section 421(b) of the Trade Act.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 3 2013-04-01 2013-04-01 false Special rules for conducting investigations under section 421(b) of the Trade Act. 206.44a Section 206.44a Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL AND BILATERAL SAFEGUARD ACTIONS...

19 CFR 206.44a - Special rules for conducting investigations under section 421(b) of the Trade Act.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 3 2014-04-01 2014-04-01 false Special rules for conducting investigations under section 421(b) of the Trade Act. 206.44a Section 206.44a Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL AND BILATERAL SAFEGUARD ACTIONS...

48 CFR 970.2672 - Implementation of Section 3161 of the National Defense Authorization Act for Fiscal Year 1993.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Implementation of Section 3161 of the National Defense Authorization Act for Fiscal Year 1993. 970.2672 Section 970.2672 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Other Socioeconomic...

48 CFR 970.2672 - Implementation of Section 3161 of the National Defense Authorization Act for Fiscal Year 1993.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Implementation of Section 3161 of the National Defense Authorization Act for Fiscal Year 1993. 970.2672 Section 970.2672 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Other Socioeconomic...

48 CFR 970.2672 - Implementation of Section 3161 of the National Defense Authorization Act for Fiscal Year 1993.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Implementation of Section 3161 of the National Defense Authorization Act for Fiscal Year 1993. 970.2672 Section 970.2672 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Other Socioeconomic...

48 CFR 970.2672 - Implementation of Section 3161 of the National Defense Authorization Act for Fiscal Year 1993.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Implementation of Section 3161 of the National Defense Authorization Act for Fiscal Year 1993. 970.2672 Section 970.2672 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Other Socioeconomic...

48 CFR 970.2672 - Implementation of Section 3161 of the National Defense Authorization Act for Fiscal Year 1993.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Implementation of Section 3161 of the National Defense Authorization Act for Fiscal Year 1993. 970.2672 Section 970.2672 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Other Socioeconomic...

An analysis of candidates for addition to the Clean Air Act list of hazardous air pollutants.

PubMed

Lunder, Sonya; Woodruff, Tracey J; Axelrad, Daniel A

2004-02-01

There are 188 air toxics listed as hazardous air pollutants (HAPs) in the Clean Air Act (CAA), based on their potential to adversely impact public health. This paper presents several analyses performed to screen potential candidates for addition to the HAPs list. We analyzed 1086 HAPs and potential HAPs, including chemicals regulated by the state of California or with emissions reported to the Toxics Release Inventory (TRI). HAPs and potential HAPs were ranked by their emissions to air, and by toxicity-weighted (tox-wtd) emissions for cancer and noncancer, using emissions information from the TRI and toxicity information from state and federal agencies. Separate consideration was given for persistent, bioaccumulative toxins (PBTs), reproductive or developmental toxins, and chemicals under evaluation for regulation as toxic air contaminants in California. Forty-four pollutants were identified as candidate HAPs based on three ranking analyses and whether they were a PBT or a reproductive or developmental toxin. Of these, nine qualified in two or three different rankings (ammonia [NH3], copper [Cu], Cu compounds, nitric acid [HNO3], N-methyl-2-pyrrolidone, sulfuric acid [H2SO4], vanadium [V] compounds, zinc [Zn], and Zn compounds). This analysis suggests further evaluation of several pollutants for possible addition to the CAA list of HAPs.

76 FR 4569 - Implementing the Whistleblower Provisions of Section 23 of the Commodity Exchange Act

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

... COMMODITY FUTURES TRADING COMMISSION 17 CFR Part 165 RIN Number 3038-AD04 Implementing the Whistleblower Provisions of Section 23 of the Commodity Exchange Act Correction In proposed rule document 2010-29022, beginning on page 75728 in the issue of Monday, December 6, 2010, make the following correction...

76 FR 81727 - Approval and Promulgation of Implementation Plans; Oklahoma; Federal Implementation Plan for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-28

...EPA is partially approving and partially disapproving a revision to the Oklahoma State Implementation Plan (SIP) submitted by the State of Oklahoma through the Oklahoma Department of Environmental Quality on February 19, 2010, intended to address the regional haze requirements of the Clean Air Act (CAA). In addition, EPA is partially approving and partially disapproving a portion of a revision to the Oklahoma SIP submitted by the State of Oklahoma on May 10, 2007 and supplemented on December 10, 2007 to address the requirements of CAA section 110(a)(2)(D)(i)(II) as it applies to visibility for the 1997 8- hour ozone and 1997 fine particulate matter National Ambient Air Quality Standards. This CAA requirement is intended to prevent emissions from one state from interfering with the visibility programs in another state. EPA is approving certain core elements of the SIP including Oklahoma's: determination of baseline and natural visibility conditions; coordinating regional haze and reasonably attributable visibility impairment; monitoring strategy and other implementation requirements; coordination with states and Federal Land Managers; and a number of NOX, SO2, and PM BART determinations. EPA is finding that Oklahoma's regional haze SIP did not address the sulfur dioxide Best Available Retrofit Technology requirements for six units in Oklahoma in accordance with the Regional Haze requirements, or the requirement to prevent interference with other states' visibility programs. EPA is promulgating a Federal Implementation Plan to address these deficiencies by requiring emissions to be reduced at these six units. This action is being taken under section 110 and part C of the CAA.

34 CFR 367.32 - How does the Secretary reallot funds under section 752(j)(4) of the Act?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false How does the Secretary reallot funds under section 752(j)(4) of the Act? 367.32 Section 367.32 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION...

34 CFR 367.32 - How does the Secretary reallot funds under section 752(j)(4) of the Act?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 2 2011-07-01 2010-07-01 true How does the Secretary reallot funds under section 752(j)(4) of the Act? 367.32 Section 367.32 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION...

Tank Level Detection Devices for the Carriage of Oil : Oil Pollution Act of 1990, Section 4110

DOT National Transportation Integrated Search

1992-12-29

This study was conducted to assess the technical feasibility of satisfying the requirements of Section 4110 of the Oil Pollution Act of 1990 (OPA 90), which calls for minimum regulatory standards tank level monitoring devices in teh cargo tanks of ta...

32 CFR 174.15 - Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993. 174.15 Section 174.15 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CLOSURES AND REALIGNMENT REVITALIZING BASE CLOSURE COMMUNITIES AND ADDRESSING IMPACTS OF REALIGNMENT...

32 CFR 174.15 - Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993. 174.15 Section 174.15 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CLOSURES AND REALIGNMENT REVITALIZING BASE CLOSURE COMMUNITIES AND ADDRESSING IMPACTS OF REALIGNMENT...

32 CFR 174.15 - Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993. 174.15 Section 174.15 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CLOSURES AND REALIGNMENT REVITALIZING BASE CLOSURE COMMUNITIES AND ADDRESSING IMPACTS OF REALIGNMENT...

32 CFR 174.15 - Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 1 2014-07-01 2014-07-01 false Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993. 174.15 Section 174.15 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CLOSURES AND REALIGNMENT REVITALIZING BASE CLOSURE COMMUNITIES AND ADDRESSING IMPACTS OF REALIGNMENT...

32 CFR 174.15 - Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993. 174.15 Section 174.15 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CLOSURES AND REALIGNMENT REVITALIZING BASE CLOSURE COMMUNITIES AND ADDRESSING IMPACTS OF REALIGNMENT...

19 CFR 206.44a - Special rules for conducting investigations under section 421(b) of the Trade Act.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 3 2011-04-01 2011-04-01 false Special rules for conducting investigations under section 421(b) of the Trade Act. 206.44a Section 206.44a Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL AND BILATERAL SAFEGUARD ACTIONS, MARKET DISRUPTION, TRADE DIVERSION...

19 CFR 206.44a - Special rules for conducting investigations under section 421(b) of the Trade Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Special rules for conducting investigations under section 421(b) of the Trade Act. 206.44a Section 206.44a Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL AND BILATERAL SAFEGUARD ACTIONS, MARKET DISRUPTION, TRADE DIVERSION...

75 FR 34434 - Request To Amend an Existing Order Under Section 4(c) of the Commodity Exchange Act Permitting...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-17

...) pursuant to Section 4(c) of the Act, (a) to permit the clearing of coffee, sugar, and cocoa OTC swap..., ``a * * * commodity swap,'' which latter term includes swaps on agricultural products. While the...(c) of the Act, ICE Clear could not engage in the clearing of OTC swap contracts in cocoa, sugar and...

75 FR 56423 - Approval and Promulgation of Implementation Plans; Texas; Revisions to the New Source Review (NSR...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-15

...EPA is taking final action to disapprove submittals from the State of Texas, through the Texas Commission on Environmental Quality (TCEQ), to revise the Texas Major and Minor NSR SIP. We are disapproving the submittals because they do not meet the 2002 revised Major NSR SIP requirements. We are also disapproving the submittals as not meeting the Major Nonattainment NSR SIP requirements for implementation of the 1997 8-hour ozone national ambient air quality standard (NAAQS) and the 1-hour ozone NAAQS. EPA is disapproving the submitted Standard Permit (SP) for Pollution Control Projects (PCP) because it does not meet the requirements of the CAA for a minor NSR Standard Permit program. Finally, EPA is also disapproving a submitted severable definition of best available control technology (BACT) that is used by TCEQ in its Minor NSR SIP permitting program. EPA is not addressing the submitted revisions concerning the Texas Major PSD NSR SIP, which will be addressed in a separate action. EPA is taking no action on severable provisions that implement section 112(g) of the Act and is restoring a clarification to an earlier action that removed an explanation that a particular provision is not in the SIP because it implements section 112(g) of the Act. EPA is not addressing severable revisions to definitions submitted June 10, 2005, submittal, which will be addressed in a separate action. We are taking no action on a severable provision relating to Emergency and Temporary Orders, which we will address in a separate action. EPA is taking these actions under section 110, part C, and part D, of the Federal Clean Air Act (the Act or CAA).

75 FR 17917 - Clean Water Act Section 303(d): Final Agency Action on Seven Total Maximum Daily Loads (TMDLs) in...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9135-1] Clean Water Act Section 303(d): Final Agency Action... the Clean Water Act (CWA). Documents from the administrative record file for the seven TMDLs... Oxygen. 010401 East Atchafalaya Mercury. Basin and Morganza Floodway South to Interstate 10 Canal. 010501...

19 CFR 351.217 - Reviews to implement results of subsidies enforcement proceeding under section 751(g) of the Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... enforcement proceeding under section 751(g) of the Act. 351.217 Section 351.217 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Antidumping and...) Violations of Article 8 of the Subsidies Agreement. If: (1) The Secretary receives notice from the Trade...

The new follow-on-biologics law: a section by section analysis of the patent litigation provisions in the Biologics Price Competition and Innovation Act of 2009.

PubMed

Dougherty, Michael P

2010-01-01

An abbreviated pathway for the approval of biosimilar biological products, often called "follow-on biologics," has been enacted into law as part of the health care legislation recently passed by Congress and signed by the President. The subtitle of the health care bill establishing this approval pathway, the Biologics Price Competition and Innovation Act of 2009, includes many provisions governing the identification of patents relevant to a given biosimilar biological product and the assertion of those patents in infringement suits. This article provides a section-by-section analysis of the patent-related provisions of the new approval pathway for biosimilar biological products, and points out several ways in which the new law differs fundamentally from the Hatch-Waxman Act, which provides the approval pathway for generic versions of small molecule drugs.

76 FR 14419 - Exercise of Authority Under Section 212(d)(3)(B)(i) of the Immigration and Nationality Act

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-16

...)(3)(B)(i) of the Immigration and Nationality Act AGENCY: Office of the Secretary, DHS. ACTION: Notice... authority granted to me by section 212(d)(3)(B)(i) of the Immigration and Nationality Act (INA), 8 U.S.C.... Implementation of this determination will be made by U.S. Citizenship and Immigration Services (USCIS), in...

76 FR 14418 - Exercise of Authority Under Section 212(d)(3)(B)(i) of the Immigration and Nationality Act

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-16

...)(3)(B)(i) of the Immigration and Nationality Act AGENCY: Office of the Secretary, DHS. ACTION: Notice... authority granted to me by section 212(d)(3)(B)(i) of the Immigration and Nationality Act (INA), 8 U.S.C... of this determination will be made by U.S. Citizenship and Immigration Services (USCIS), in...

77 FR 61513 - Information Disclosure Under Section 6(b) of the Consumer Product Safety Act

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-10

... CONSUMER PRODUCT SAFETY COMMISSION 16 CFR Part 1101 Information Disclosure Under Section 6(b) of the Consumer Product Safety Act CFR Correction 0 In Title 16 of the Code of Federal Regulations, Part 1000 to End, revised as of January 1, 2012, on page 147, in Sec. 1101.25 (a) and (b), the words ``5...

Homosexual Cohabitees Act, 18 June 1987.

PubMed

1989-01-01

The purpose of this Act is to place homosexual cohabitees in the same legal position as heterosexual cohabitees. It provides that if 2 persons are living together in a homosexual relationship, the following legal provisions relating to cohabitation shall apply to them: 1) the Cohabitees (Joint Homes) Act (1987:232), 2) the Inheritance Code, 3) the Real Property Code, 4) Chapter 10, section 9, of the Code of Judicial Procedure, 5) Chapter 4, section 19, 1st paragraph, of the Code of Execution, 6) section 19, 1st paragraph, section 35, subsection 4, and point 2a, 7th paragraph, of the regulations relating to Section 36 of the Municipal Tax Act (1928:370), 7) the Inheritance and Gift Taxes Act (1941:416), 8) Section 6 of the Court Procedures (Miscellaneous Business) Act (1946:807), 9) the Tenant Owner Act (1971:479), 10) section 10 of the Legal Aid Act (1972:429), and 11) the Notice to Unknown Creditors Act (1981:131).

76 FR 2130 - Exercise of Authority Under Section 212(d)(3)(B)(i) of the Immigration and Nationality Act

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-12

...)(3)(B)(i) of the Immigration and Nationality Act AGENCY: Office of the Secretary, DHS. ACTION: Notice... authority granted to me by section 212(d)(3)(B)(i) of the Immigration and Nationality Act (INA), 8 U.S.C... determination will be made by U.S. Citizenship and Immigration Services (USCIS), in consultation with U.S...

76 FR 2131 - Exercise of Authority Under Section 212(d)(3)(B)(i) of the Immigration and Nationality Act

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-12

...)(3)(B)(i) of the Immigration and Nationality Act AGENCY: Office of the Secretary, DHS. ACTION: Notice... authority granted to me by section 212(d)(3)(B)(i) of the Immigration and Nationality Act (INA), 8 U.S.C... Immigration Services (USCIS), in consultation with U.S. Immigration and Customs Enforcement (ICE), or by U.S...

Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds.

PubMed

Dumitriu, Gina-Mirabela; Bîcu, Elena; Belei, Dalila; Rigo, Benoît; Dubois, Joëlle; Farce, Amaury; Ghinet, Alina

2015-10-15

A new family of CaaX competitive inhibitors of human farnesyltransferase based on phenothiazine and carbazole skeleton bearing a l-cysteine, l-methionine, l-serine or l-valine moiety was designed, synthesized and biologically evaluated. Phenothiazine derivatives proved to be more active than carbazole-based compounds. Phenothiazine 1b with cysteine residue was the most promising inhibitor of human farnesyltransferase in the current study. Copyright © 2015 Elsevier Ltd. All rights reserved.

METHANOL: THE CURRENT STATUS OF ENVIRONMENTAL HEALTH ISSUES

EPA Science Inventory

Methanol has been a topic of interest both as an environmental pollutant and as a fuel. The Clean Air Act (CAA) includes methanol in a list of 189 toxic air pollutants that the U.S. Congress identified for special consideration in the 1990 CAA Amendments. In addition, growing i...

75 FR 12087 - Determination of Attainment, Approval and Promulgation of Air Quality Implementation Plans; Indiana

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-12

... the Clean Air Act (CAA) affecting the Indiana portion (Lake and Porter Counties) of the Chicago-Gary... Oxides (NO X ) in Lake and Porter Counties from CAA Reasonably Available Control Technology (RACT... Lake and Porter Counties, also published in today's Federal Register, the Chicago-Gary-Lake County, IL...

Clean Water Act (excluding Section 404). Environmental guidance program reference book: Revision 6

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-01-15

This Reference Book contains a current copy of the Clean Water Act (excluding Section 404) and those regulations that implement the statutes and appear to be most relevant to US Department of Energy (DOE) activities. The document is provided to DOE and contractor staff for informational purposes only and should not be interpreted as legal guidance. Updates that include important new requirements will be provided periodically. Questions concerning this Reference Book may be directed to Mark Petts, EH-231 (202/586-2609).

48 CFR 25.703-3 - Comprehensive Iran Sanctions, Accountability, and Divestment Act of 2010, section 106.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Comprehensive Iran... Prohibited Sources 25.703-3 Comprehensive Iran Sanctions, Accountability, and Divestment Act of 2010, section... of goods or services with a person that exports certain sensitive technology to Iran, as determined...

48 CFR 25.703-3 - Comprehensive Iran Sanctions, Accountability, and Divestment Act of 2010, section 106.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Comprehensive Iran... Prohibited Sources 25.703-3 Comprehensive Iran Sanctions, Accountability, and Divestment Act of 2010, section... goods or services with a person that exports certain sensitive technology to Iran, as determined by the...

48 CFR 25.703-3 - Comprehensive Iran Sanctions, Accountability, and Divestment Act of 2010, section 106.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Comprehensive Iran... Prohibited Sources 25.703-3 Comprehensive Iran Sanctions, Accountability, and Divestment Act of 2010, section... goods or services with a person that exports certain sensitive technology to Iran, as determined by the...

3 CFR - Delegation of Authority Under Section 506(a)(1) of the Foreign Assistance Act of 1961, as Amended

Code of Federal Regulations, 2014 CFR

2014-01-01

... 3 The President 1 2014-01-01 2014-01-01 false Delegation of Authority Under Section 506(a)(1) of the Foreign Assistance Act of 1961, as Amended Presidential Documents Other Presidential Documents... by the Constitution and the laws of the United States of America, including section 301 of title 3...

Free Appropriate Public Education for Students with Disabilities: Requirements under Section 504 of the "Rehabilitation Act of 1973." Revised

ERIC Educational Resources Information Center

US Department of Education, 2007

2007-01-01

Section 504 of the "Rehabilitation Act of 1973" protects the rights of individuals with disabilities in programs and activities that receive federal funds. The Section 504 regulation requires a school district to provide a "free appropriate public education" (FAPE) to each qualified person with a disability who is in the school…

Procedures for the handling of retaliation complaints under section 1558 of the Affordable Care Act. Interim final rule; request for comments.

PubMed

2013-02-27

This document provides the interim final regulations governing the employee protection (whistleblower) provision of section 1558 of the Affordable Care Act, which added section 18C of the Fair Labor Standards Act, to provide protections to employees of health insurance issuers or other employers who may have been subject to retaliation for reporting potential violations of the law's consumer protections (e.g., the prohibition on denials of insurance due to pre-existing conditions) or affordability assistance provisions (e.g., access to health insurance premium tax credits). This interim rule establishes procedures and time frames for the handling of retaliation complaints under section 18C, including procedures and time frames for employee complaints to the Occupational Safety and Health Administration (OSHA), investigations by OSHA, appeals of OSHA determinations to an administrative law judge (ALJ) for a hearing de novo, hearings by ALJs, review of ALJ decisions by the Administrative Review Board (ARB) (acting on behalf of the Secretary of Labor), and judicial review of the Secretary's final decision.

12 CFR 225.109 - “Services” under section 4(c)(1) of Bank Holding Company Act.

Code of Federal Regulations, 2011 CFR

2011-01-01

... section 4 (c)(6) of the Act. (e) The only activity of the insurance company (writing comprehensive... insurance company; and that the insurance company receives the usual agency commissions on all comprehensive automobile insurance written for customers of the bank. (c) It is also understood that the insurance company...

75 FR 24409 - Designation of Areas for Air Quality Planning Purposes; California; San Joaquin Valley, South...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-05

... certain fee rules under section 185 of the CAA. A number of Indian tribes have Indian country located... CAA programs in Indian country, and the relevant Indian tribes have not applied for eligibility to... reclassification provisions of the CAA in these Indian country areas and is reclassifying these areas, except...

3 CFR - Delegation of Authority Under Sections 552(c)(2) and 614 of the Foreign Assistance Act of 1961...

Code of Federal Regulations, 2014 CFR

2014-01-01

... 3 The President 1 2014-01-01 2014-01-01 false Delegation of Authority Under Sections 552(c)(2) and 614 of the Foreign Assistance Act of 1961, as Amended Presidential Documents Other Presidential... section 301 of title 3, United States Code, I hereby delegate to the Secretary of State: (1) the authority...

Letter from A & R Transport about Section 308 of the Clean Water Act Discharge of Perfluorinated Compounds

EPA Pesticide Factsheets

January 16, 2009 letter from Kenneth E. Pate, VP of Safety and Risk Management of A & R Transport, Inc. to EPA Clean Water Enforcement Branch, about an Information Request about the Section 308 of the Clean Water Act, discharge of pefluorinated compounds.

78 FR 23149 - Air Quality: Revision to Definition of Volatile Organic Compounds-Exclusion of trans 1-chloro-3,3...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-18

... contribution to tropospheric ozone formation. Because EPA received one adverse comment, we are withdrawing the... air quality standards (NAAQS) for ozone under title I of the Clean Air Act (CAA). The direct final... of preparing SIPs to attain the NAAQS for ozone under title I of the CAA. If it had become effective...

32 CFR Appendix A to Part 1292 - Section 21 of the Internal Security Act of 1950

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Section 21 of the Internal Security Act of 1950 A Appendix A to Part 1292 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS SECURITY OF DLA ACTIVITIES AND RESOURCES Pt. 1292, App. A Appendix A to Part...

32 CFR Appendix A to Part 1292 - Section 21 of the Internal Security Act of 1950

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 6 2013-07-01 2013-07-01 false Section 21 of the Internal Security Act of 1950 A Appendix A to Part 1292 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS SECURITY OF DLA ACTIVITIES AND RESOURCES Pt. 1292, App. A Appendix A to Part...

32 CFR Appendix A to Part 1292 - Section 21 of the Internal Security Act of 1950

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 6 2011-07-01 2011-07-01 false Section 21 of the Internal Security Act of 1950 A Appendix A to Part 1292 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS SECURITY OF DLA ACTIVITIES AND RESOURCES Pt. 1292, App. A Appendix A to Part...

32 CFR Appendix A to Part 1292 - Section 21 of the Internal Security Act of 1950

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 6 2014-07-01 2014-07-01 false Section 21 of the Internal Security Act of 1950 A Appendix A to Part 1292 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS SECURITY OF DLA ACTIVITIES AND RESOURCES Pt. 1292, App. A Appendix A to Part...

32 CFR Appendix A to Part 1292 - Section 21 of the Internal Security Act of 1950

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 6 2012-07-01 2012-07-01 false Section 21 of the Internal Security Act of 1950 A Appendix A to Part 1292 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS SECURITY OF DLA ACTIVITIES AND RESOURCES Pt. 1292, App. A Appendix A to Part...

40 CFR 131.41 - Bacteriological criteria for those states not complying with Clean Water Act section 303(i)(1)(A).

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Bacteriological criteria for those states not complying with Clean Water Act section 303(i)(1)(A). 131.41 Section 131.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS Federally...

40 CFR 131.41 - Bacteriological criteria for those states not complying with Clean Water Act section 303(i)(1)(A).

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Bacteriological criteria for those states not complying with Clean Water Act section 303(i)(1)(A). 131.41 Section 131.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS Federally...

40 CFR 131.41 - Bacteriological criteria for those states not complying with Clean Water Act section 303(i)(1)(A).

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Bacteriological criteria for those states not complying with Clean Water Act section 303(i)(1)(A). 131.41 Section 131.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS Federally...

40 CFR 131.41 - Bacteriological criteria for those states not complying with Clean Water Act section 303(i)(1)(A).

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Bacteriological criteria for those states not complying with Clean Water Act section 303(i)(1)(A). 131.41 Section 131.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS Federally...

40 CFR 131.41 - Bacteriological criteria for those states not complying with Clean Water Act section 303(i)(1)(A).

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Bacteriological criteria for those states not complying with Clean Water Act section 303(i)(1)(A). 131.41 Section 131.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS Federally...

75 FR 30799 - Notice of a Waiver of Section 1605 of the American Recovery and Reinvestment Act of 2009 (ARRA...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-02

... DEPARTMENT OF EDUCATION Notice of a Waiver of Section 1605 of the American Recovery and... 1605 of the American Recovery and Reinvestment Act of 2009 (ARRA) for Poplar School District, Poplar... Buy American requirements in section 1605(a) of the ARRA (Buy American Requirements) for the Poplar...