Sample records for active protection systems

  1. Army and Marine Corps Active Protection System (APS) Efforts

    DTIC Science & Technology

    2016-08-30

    efforts—the Expedited, Non-Developmental Item (NDI) APS effort and the Modular Active Protection System (MAPS) effort. The Marines describe their...17 Modular Active Protection System (MAPS) Effort .......................................................... 18 The Marine Corps APS...Merkava Mark 4 tank was designed around the Trophy APS. 32 The Army’s Modular Active Protection System (MAPS) effort, described below, is intended to

  2. Feasibility of the MUSIC Algorithm for the Active Protection System

    DTIC Science & Technology

    2001-03-01

    Feasibility of the MUSIC Algorithm for the Active Protection System ARL-MR-501 March 2001 Canh Ly Approved for public release; distribution... MUSIC Algorithm for the Active Protection System Canh Ly Sensors and Electron Devices Directorate Approved for public release; distribution unlimited...This report compares the accuracy of the doppler frequency of an incoming projectile with the use of the MUSIC (multiple signal classification

  3. Active Wireless Temperature Sensors for Aerospace Thermal Protection Systems

    NASA Technical Reports Server (NTRS)

    Milos, Frank S.; Karunaratne, K.; Arnold, Jim (Technical Monitor)

    2002-01-01

    Health diagnostics is an area where major improvements have been identified for potential implementation into the design of new reusable launch vehicles in order to reduce life-cycle costs, to increase safety margins, and to improve mission reliability. NASA Ames is leading the effort to advance inspection and health management technologies for thermal protection systems. This paper summarizes a joint project between NASA Ames and Korteks to develop active wireless sensors that can be embedded in the thermal protection system to monitor sub-surface temperature histories. These devices are thermocouples integrated with radio-frequency identification circuitry to enable acquisition and non-contact communication of temperature data through aerospace thermal protection materials. Two generations of prototype sensors are discussed. The advanced prototype collects data from three type-k thermocouples attached to a 2.54-cm square integrated circuit.

  4. Motivating Power System Protection Course Students by Practical and Computer-Based Activities

    ERIC Educational Resources Information Center

    Shahnia, Farhad; Moghbel, Moayed; Yengejeh, Hadi Hosseinian

    2016-01-01

    This paper presents several methods for motivating students taking a power system protection (PSP) course. The paper reviews the laboratory activities developed for the PSP course at Curtin University, Australia; these methods are applicable and can be used for PSP course instruction at any institution. These activities were developed to improve…

  5. Soil microflora and enzyme activities in rhizosphere of Transgenic Bt cotton hybrid under different intercropping systems and plant protection schedules

    NASA Astrophysics Data System (ADS)

    Biradar, D. P.; Alagawadi, A. R.; Basavanneppa, M. A.; Udikeri, S. S.

    2012-04-01

    Field experiments were conducted over three rainy seasons of 2005-06 to 2007-08 on a Vertisol at Dharwad, Karnataka, India to study the effect of intercropping and plant protection schedules on productivity, soil microflora and enzyme activities in the rhizosphere of transgenic Bt cotton hybrid. The experiment consisted of four intercropping systems namely, Bt cotton + okra, Bt cotton + chilli, Bt cotton + onion + chilli and Bt cotton + redgram with four plant protection schedules (zero protection, protection for Bt cotton, protection for intercrop and protection for both crops). Observations on microbial populations and enzyme activities were recorded at 45, 90, 135 and 185 (at harvest) days after sowing (DAS). Averaged over years, Bt cotton + okra intercropping had significantly higher total productivity than Bt cotton + chilli and Bt cotton + redgram intercropping system and was similar to Bt cotton + chilli + onion intercropping system. With respect to plant protection schedules for bollworms, protection for both cotton and intercrops recorded significantly higher yield than the rest of the treatments. Population of total bacteria, fungi, actinomycetes, P-solubilizers, free-living N2 fixers as well as urease, phosphatase and dehydrogenase enzyme activities increased up to 135 days of crop growth followed by a decline. Among the intercropping systems, Bt cotton + chilli recorded significantly higher population of microorganisms and enzyme activities than other cropping systems. While Bt cotton with okra as intercrop recorded the least population of total bacteria and free-living N2 fixers as well as urease activity. Intercropping with redgram resulted in the least population of actinomycetes, fungi and P-solubilizers, whereas Bt cotton with chilli and onion recorded least activities of dehydrogenase and phosphatase. Among the plant protection schedules, zero protection recorded maximum population of microorganisms and enzyme activities. This was followed by the

  6. Well logging evaporative thermal protection system

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lamers, M.D.; Martelli, V.P.

    1981-02-03

    An evaporative thermal protection system for use in hostile environment well logging applications, the system including a downhole thermal protection cartridge disposed within a well logging sonde or tool to keep a payload such as sensors and support electronics cool, the cartridge carrying either an active evaporative system for refrigeration or a passive evaporative system, both exhausting to the surface through an armored flexible fluidic communication mechanical cable.

  7. Current Technology for Thermal Protection Systems

    NASA Technical Reports Server (NTRS)

    Scotti, Stephen J. (Compiler)

    1992-01-01

    Interest in thermal protection systems for high-speed vehicles is increasing because of the stringent requirements of such new projects as the Space Exploration Initiative, the National Aero-Space Plane, and the High-Speed Civil Transport, as well as the needs for improved capabilities in existing thermal protection systems in the Space Shuttle and in turbojet engines. This selection of 13 papers from NASA and industry summarizes the history and operational experience of thermal protection systems utilized in the national space program to date, and also covers recent development efforts in thermal insulation, refractory materials and coatings, actively cooled structures, and two-phase thermal control systems.

  8. Advanced extravehicular protective systems

    NASA Technical Reports Server (NTRS)

    Sutton, J. G.; Heimlich, P. F.; Tepper, E. H.

    1972-01-01

    New technologies are identified and recommended for developing a regenerative portable life support system that provides protection for extravehicular human activities during long duration missions on orbiting space stations, potential lunar bases, and possible Mars landings. Parametric subsystems analyses consider: thermal control, carbon dioxide control, oxygen supply, power supply, contaminant control, humidity control, prime movers, and automatic temperature control.

  9. Extravehicular Activity Probabilistic Risk Assessment Overview for Thermal Protection System Repair on the Hubble Space Telescope Servicing Mission

    NASA Technical Reports Server (NTRS)

    Bigler, Mark; Canga, Michael A.; Duncan, Gary

    2010-01-01

    The Shuttle Program initiated an Extravehicular Activity (EVA) Probabilistic Risk Assessment (PRA) to assess the risks associated with performing a Shuttle Thermal Protection System (TPS) repair during the Space Transportation System (STS)-125 Hubble repair mission as part of risk trades between TPS repair and crew rescue.

  10. ADVANCED WORKER PROTECTION SYSTEM

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Judson Hedgehock

    2001-03-16

    From 1993 to 2000, OSS worked under a cost share contract from the Department of Energy (DOE) to develop an Advanced Worker Protection System (AWPS). The AWPS is a protective ensemble that provides the user with both breathing air and cooling for a NIOSH-rated duration of two hours. The ensemble consists of a liquid air based backpack, a Liquid Cooling Garment (LCG), and an outer protective garment. The AWPS project was divided into two phases. During Phase 1, OSS developed and tested a full-scale prototype AWPS. The testing showed that workers using the AWPS could work twice as long asmore » workers using a standard SCBA. The testing also provided performance data on the AWPS in different environments that was used during Phase 2 to optimize the design. During Phase 1, OSS also performed a life-cycle cost analysis on a representative clean up effort. The analysis indicated that the AWPS could save the DOE millions of dollars on D and D activities and improve the health and safety of their workers. During Phase 2, OSS worked to optimize the AWPS design to increase system reliability, to improve system performance and comfort, and to reduce the backpack weight and manufacturing costs. To support this design effort, OSS developed and tested several different generations of prototype units. Two separate successful evaluations of the ensemble were performed by the International Union of Operation Engineers (IUOE). The results of these evaluations were used to drive the design. During Phase 2, OSS also pursued certifying the AWPS with the applicable government agencies. The initial intent during Phase 2 was to finalize the design and then to certify the system. OSS and Scott Health and Safety Products teamed to optimize the AWPS design and then certify the system with the National Institute of Occupational Health and Safety (NIOSH). Unfortunately, technical and programmatic difficulties prevented us from obtaining NIOSH certification. Despite the inability of NIOSH to

  11. Accelerator Vacuum Protection System

    NASA Astrophysics Data System (ADS)

    Barua, Pradip; Kothari, Ashok; Archunan, M.; Joshi, Rajan

    2012-11-01

    A new and elaborate automatic vacuum protection system using fast acting valve has been installed to avoid accidental venting of accelerator from experimental chamber side. To cover all the beam lines and to reduce the system cost, it has been installed at a common point from where all the seven beam lines originate. The signals are obtained by placing fast response pressure sensing gauges (HV SENSOR) near all the experimental stations. The closing time of the fast valve is 10 milli-second. The fast closing system protects only one vacuum line at a time. At IUAC, we have seven beam lines so one sensor was placed in each of the beam lines near experimental chamber and a multiplexer was incorporated into the fast closing system. At the time of experiment, the sensor of the active beam line is selected through the multiplexer and the Fast closing valve is interlocked with the selected sensor. As soon as the pressure sensor senses the pressure rise beyond a selected pressure, the signal is transferred and the fast valve closes within 10 to 12 millisecond.

  12. A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity*

    PubMed Central

    Lok, Hiu Chuen; Sahni, Sumit; Jansson, Patric J.; Kovacevic, Zaklina; Hawkins, Clare L.; Richardson, Des R.

    2016-01-01

    Nitric oxide (NO) is integral to macrophage cytotoxicity against tumors due to its ability to induce iron release from cancer cells. However, the mechanism for how activated macrophages protect themselves from endogenous NO remains unknown. We previously demonstrated by using tumor cells that glutathione S-transferase P1 (GSTP1) sequesters NO as dinitrosyl-dithiol iron complexes (DNICs) and inhibits NO-mediated iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1). These prior studies also showed that MRP1 and GSTP1 protect tumor cells against NO cytotoxicity, which parallels their roles in defending cancer cells from cytotoxic drugs. Considering this, and because GSTP1 and MRP1 are up-regulated during macrophage activation, this investigation examined whether this NO storage/transport system protects macrophages against endogenous NO cytotoxicity in two well characterized macrophage cell types (J774 and RAW 264.7). MRP1 expression markedly increased upon macrophage activation, and the role of MRP1 in NO-induced 59Fe release was demonstrated by Mrp1 siRNA and the MRP1 inhibitor, MK571, which inhibited NO-mediated iron efflux. Furthermore, Mrp1 silencing increased DNIC accumulation in macrophages, indicating a role for MRP1 in transporting DNICs out of cells. In addition, macrophage 59Fe release was enhanced by silencing Gstp1, suggesting GSTP1 was responsible for DNIC binding/storage. Viability studies demonstrated that GSTP1 and MRP1 protect activated macrophages from NO cytotoxicity. This was confirmed by silencing nuclear factor-erythroid 2-related factor 2 (Nrf2), which decreased MRP1 and GSTP1 expression, concomitant with reduced 59Fe release and macrophage survival. Together, these results demonstrate a mechanism by which macrophages protect themselves against NO cytotoxicity. PMID:27866158

  13. 30 CFR 865.11 - Protected activity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Protected activity. 865.11 Section 865.11 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR PROTECTION OF EMPLOYEES PROTECTION OF EMPLOYEES § 865.11 Protected activity. (a) No person shall discharge or...

  14. 30 CFR 865.11 - Protected activity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Protected activity. 865.11 Section 865.11 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR PROTECTION OF EMPLOYEES PROTECTION OF EMPLOYEES § 865.11 Protected activity. (a) No person shall discharge or...

  15. 30 CFR 865.11 - Protected activity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Protected activity. 865.11 Section 865.11 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR PROTECTION OF EMPLOYEES PROTECTION OF EMPLOYEES § 865.11 Protected activity. (a) No person shall discharge or...

  16. 30 CFR 865.11 - Protected activity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Protected activity. 865.11 Section 865.11 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR PROTECTION OF EMPLOYEES PROTECTION OF EMPLOYEES § 865.11 Protected activity. (a) No person shall discharge or...

  17. 30 CFR 865.11 - Protected activity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Protected activity. 865.11 Section 865.11 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR PROTECTION OF EMPLOYEES PROTECTION OF EMPLOYEES § 865.11 Protected activity. (a) No person shall discharge or...

  18. Thermal protection system flight repair kit

    NASA Technical Reports Server (NTRS)

    1979-01-01

    A thermal protection system (TPS) flight repair kit required for use on a flight of the Space Transportation System is defined. A means of making TPS repairs in orbit by the crew via extravehicular activity is discussed. A cure in place ablator, a precured ablator (large area application), and packaging design (containers for mixing and dispensing) for the TPS are investigated.

  19. 21 CFR 346.14 - Protectant active ingredients.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 5 2011-04-01 2011-04-01 false Protectant active ingredients. 346.14 Section 346...) DRUGS FOR HUMAN USE ANORECTAL DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE Active Ingredients § 346.14 Protectant active ingredients. (a) The following active ingredients may be used as the sole protectant active...

  20. 21 CFR 346.14 - Protectant active ingredients.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 5 2014-04-01 2014-04-01 false Protectant active ingredients. 346.14 Section 346...) DRUGS FOR HUMAN USE ANORECTAL DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE Active Ingredients § 346.14 Protectant active ingredients. (a) The following active ingredients may be used as the sole protectant active...

  1. 21 CFR 346.14 - Protectant active ingredients.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 5 2013-04-01 2013-04-01 false Protectant active ingredients. 346.14 Section 346...) DRUGS FOR HUMAN USE ANORECTAL DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE Active Ingredients § 346.14 Protectant active ingredients. (a) The following active ingredients may be used as the sole protectant active...

  2. 21 CFR 346.14 - Protectant active ingredients.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 5 2012-04-01 2012-04-01 false Protectant active ingredients. 346.14 Section 346...) DRUGS FOR HUMAN USE ANORECTAL DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE Active Ingredients § 346.14 Protectant active ingredients. (a) The following active ingredients may be used as the sole protectant active...

  3. Protective garment ventilation system

    NASA Technical Reports Server (NTRS)

    Lang, R. (Inventor)

    1970-01-01

    A method and apparatus for ventilating a protective garment, space suit system, and/or pressure suits to maintain a comfortable and nontoxic atmosphere within is described. The direction of flow of a ventilating and purging gas in portions of the garment may be reversed in order to compensate for changes in environment and activity of the wearer. The entire flow of the ventilating gas can also be directed first to the helmet associated with the garment.

  4. The influence of protection system failures and preventive maintenance on protection systems in distribution systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Meeuwsen, J.J.; Kling, W.L.; Ploem, W.A.G.A.

    1997-01-01

    Protection systems in power systems can fail either by not responding when they should (failure to operate) or by operating when they should not (false tripping). The former type of failure is particularly serious since it may result in the isolation of large sections of the network. However, the probability of a failure to operate can be reduced by carrying out preventive maintenance on protection systems. This paper describes an approach to determine the impact of preventive maintenance on protection systems on the reliability of the power supply to customers. The proposed approach is based on Markov models.

  5. Operability of Space Station Freedom's meteoroid/debris protection system

    NASA Technical Reports Server (NTRS)

    Kahl, Maggie S.; Stokes, Jack W.

    1992-01-01

    The design of Space Station Freedom's external structure must not only protect the spacecraft from the hazardous environment, but also must be compatible with the extra vehicular activity system for assembly and maintenance. The external procedures for module support are utility connections, external orbital replaceable unit changeout, and maintenance of the meteoroid/debris shields and multilayer insulation. All of these interfaces require proper man-machine engineering to be compatible with the extra vehicular activity and manipulator systems. This paper discusses design solutions, including those provided for human interface, to the Space Station Freedom meteoroid/debris protection system. The system advantages and current access capabilities are illustrated through analysis of its configuration over the Space Station Freedom resource nodes and common modules, with emphasis on the cylindrical sections and endcones.

  6. Heat Exchange in “Human body - Thermal protection - Environment” System

    NASA Astrophysics Data System (ADS)

    Khromova, I. V.

    2017-11-01

    This article is devoted to the issues of simulation and calculation of thermal processes in the system called “Human body - Thermal protection - Environment” under low temperature conditions. It considers internal heat sources and convective heat transfer between calculated elements. Overall this is important for the Heat Transfer Theory. The article introduces complex heat transfer calculation method and local thermophysical parameters calculation method in the system called «Human body - Thermal protection - Environment», considering passive and active thermal protections, thermophysical and geometric properties of calculated elements in a wide range of environmental parameters (water, air). It also includes research on the influence that thermal resistance of modern materials, used in special protective clothes development, has on heat transfer in the system “Human body - Thermal protection - Environment”. Analysis of the obtained results allows adding of the computer research data to experiments and optimizing of individual life-support system elements, which are intended to protect human body from exposure to external factors.

  7. Structural Analysis of Lightning Protection System for New Launch Vehicle

    NASA Technical Reports Server (NTRS)

    Cope, Anne; Moore, Steve; Pruss, Richard

    2008-01-01

    This project includes the design and specification of a lightning protection system for Launch Complex 39 B (LC39B) at Kennedy Space Center, FL in support of the Constellation Program. The purpose of the lightning protection system is to protect the Crew Launch Vehicle (CLV) or Cargo Launch Vehicle (CaLV) and associated launch equipment from direct lightning strikes during launch processing and other activities prior to flight. The design includes a three-tower, overhead catenary wire system to protect the vehicle and equipment on LC39B as described in the study that preceded this design effort: KSC-DX-8234 "Study: Construct Lightning Protection System LC3 9B". The study was a collaborative effort between Reynolds, Smith, and Hills (RS&H) and ASRC Aerospace (ASRC), where ASRC was responsible for the theoretical design and risk analysis of the lightning protection system and RS&H was responsible for the development of the civil and structural components; the mechanical systems; the electrical and grounding systems; and the siting of the lightning protection system. The study determined that a triangular network of overhead catenary cables and down conductors supported by three triangular free-standing towers approximately 594 ft tall (each equipped with a man lift, ladder, electrical systems, and communications systems) would provide a level of lightning protection for the Constellation Program CLV and CaLV on Launch Pad 39B that exceeds the design requirements.

  8. 24 CFR 245.115 - Protected activities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Protected activities. 245.115 Section 245.115 Housing and Urban Development Regulations Relating to Housing and Urban Development... TENANT PARTICIPATION IN MULTIFAMILY HOUSING PROJECTS Tenant Organizations § 245.115 Protected activities...

  9. 24 CFR 245.115 - Protected activities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Protected activities. 245.115 Section 245.115 Housing and Urban Development Regulations Relating to Housing and Urban Development... TENANT PARTICIPATION IN MULTIFAMILY HOUSING PROJECTS Tenant Organizations § 245.115 Protected activities...

  10. 24 CFR 245.115 - Protected activities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Protected activities. 245.115 Section 245.115 Housing and Urban Development Regulations Relating to Housing and Urban Development... TENANT PARTICIPATION IN MULTIFAMILY HOUSING PROJECTS Tenant Organizations § 245.115 Protected activities...

  11. 24 CFR 245.115 - Protected activities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Protected activities. 245.115 Section 245.115 Housing and Urban Development Regulations Relating to Housing and Urban Development... TENANT PARTICIPATION IN MULTIFAMILY HOUSING PROJECTS Tenant Organizations § 245.115 Protected activities...

  12. [STUDY OF PROTECTIVE ACTIVITY OF PROTEIN-CONTAINING ANTIGENS OF STREPTOCOCCUS PNEUMONIAE IN A HETEROLOGOUS SYSTEM].

    PubMed

    Vorobiev, D S; Semenova, I B; Volokh, Yu V; Romanenko, E E; Baturo, A P; Mikhailova, N A

    2015-01-01

    Study protective activity of protein-containing antigens of pneumococcus, obtained from serotypes 6B, 10A, 14, 19F, 23F and 36R, against infection with heterologous strains of S. pneumoniae. S. pneumoniae strains of serotypes 3, 6B, 10A, 14, 19F, 23F and 36R, obtained from the collection of pneumococcus strains of Mechnikov RIVS, were used in the study. Protein-containing antigens of S. pneumoniae were isolated by acetone precipitations of supernatant fraction of culture medium. Protective activity of preparations of protein-containing antigens of pneumococcus as studied in experiments of active protection of BALb/c line mice. The data obtained give evidence, that protein-containing antigens of pneumococcus, isolated from serotypes 6B, 10A, 14, 19F and 23F, effectively protect animals from subsequent infection with a heterologous S. pneumoniae strain of serotype 3 No. 11/56. Protection was noted at a level from 80 to 100% (p ≤ 0.05). Similar protective effect was detected in another experiment in a group of mice, immunized with preparations of protein-containing antigens of pneumococcus, obtained from serotypes 6B and 36R, against infection with a heterologous S. pneumoniae strain of serotype 3 No. 11/56. Protection was noted at a level of 90% (p ≤ 0.05). The results of the experiments carried out allow to assume, that the main role in formation of cross-protection in experiments in animals is played by pneumococcus, proteins, that are a part of the studied preparations, and not polysaccharide antigens.

  13. 18 CFR 1316.8 - Employee protected activities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Employee protected... Conditions and Certifications § 1316.8 Employee protected activities. When so indicated in TVA contract... Protected Activities (Applicable to contracts for goods or services delivered to nuclear facilities or...

  14. 18 CFR 1316.8 - Employee protected activities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Employee protected... Conditions and Certifications § 1316.8 Employee protected activities. When so indicated in TVA contract... Protected Activities (Applicable to contracts for goods or services delivered to nuclear facilities or...

  15. 18 CFR 1316.8 - Employee protected activities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Employee protected... Conditions and Certifications § 1316.8 Employee protected activities. When so indicated in TVA contract... Protected Activities (Applicable to contracts for goods or services delivered to nuclear facilities or...

  16. 18 CFR 1316.8 - Employee protected activities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Employee protected... Conditions and Certifications § 1316.8 Employee protected activities. When so indicated in TVA contract... Protected Activities (Applicable to contracts for goods or services delivered to nuclear facilities or...

  17. 18 CFR 1316.8 - Employee protected activities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Employee protected... Conditions and Certifications § 1316.8 Employee protected activities. When so indicated in TVA contract... Protected Activities (Applicable to contracts for goods or services delivered to nuclear facilities or...

  18. 42 CFR 51.31 - Conduct of protection and advocacy activities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Conduct of protection and advocacy activities. 51.31 Section 51.31 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS... shall establish policies and procedures to guide and coordinate advocacy activities. The P&A system...

  19. Involvement of endogenous antioxidant systems in the protective activity of pituitary adenylate cyclase-activating polypeptide against hydrogen peroxide-induced oxidative damages in cultured rat astrocytes.

    PubMed

    Douiri, Salma; Bahdoudi, Seyma; Hamdi, Yosra; Cubì, Roger; Basille, Magali; Fournier, Alain; Vaudry, Hubert; Tonon, Marie-Christine; Amri, Mohamed; Vaudry, David; Masmoudi-Kouki, Olfa

    2016-06-01

    Astroglial cells possess an array of cellular defense mechanisms, including superoxide dismutase (SOD) and catalase antioxidant enzymes, to prevent damages caused by oxidative stress. Nevertheless, astroglial cell viability and functionality can be affected by significant oxidative stress. We have previously shown that pituitary adenylate cyclase-activating polypeptide (PACAP) is a potent glioprotective agent that prevents hydrogen peroxide (H2 O2 )-induced apoptosis in cultured astrocytes. The purpose of this study was to investigate the potential protective effect of PACAP against oxidative-generated alteration of astrocytic antioxidant systems. Incubation of cells with subnanomolar concentrations of PACAP inhibited H2 O2 -evoked reactive oxygen species accumulation, mitochondrial respiratory burst, and caspase-3 mRNA level increase. PACAP also stimulated SOD and catalase activities in a concentration-dependent manner, and counteracted the inhibitory effect of H2 O2 on the activity of these two antioxidant enzymes. The protective action of PACAP against H2 O2 -evoked inhibition of antioxidant systems in astrocytes was protein kinase A, PKC, and MAP-kinase dependent. In the presence of H2 O2 , the SOD blocker NaCN and the catalase inhibitor 3-aminotriazole, both suppressed the protective effects of PACAP on SOD and catalase activities, mitochondrial function, and cell survival. Taken together, these results indicate that the anti-apoptotic effect of PACAP on astroglial cells can account for the activation of endogenous antioxidant enzymes and reduction in respiration rate, thus preserving mitochondrial integrity and preventing caspase-3 expression provoked by oxidative stress. Considering its powerful anti-apoptotic and anti-oxidative properties, the PACAPergic signaling system should thus be considered for the development of new therapeutical approaches to cure various pathologies involving oxidative neurodegeneration. We propose the following cascade for the

  20. Adaptive protection algorithm and system

    DOEpatents

    Hedrick, Paul [Pittsburgh, PA; Toms, Helen L [Irwin, PA; Miller, Roger M [Mars, PA

    2009-04-28

    An adaptive protection algorithm and system for protecting electrical distribution systems traces the flow of power through a distribution system, assigns a value (or rank) to each circuit breaker in the system and then determines the appropriate trip set points based on the assigned rank.

  1. Planetary Protection Concerns During Pre-Launch Radioisotope Power System Final Integration Activities

    NASA Technical Reports Server (NTRS)

    Chen, Fei; McKay, Terri; Spry, James A.; Colozza, Anthony J.; DiStefano, Salvador

    2012-01-01

    The Advanced Stirling Radioisotope Generator (ASRG) is a next-generation radioisotope-based power system that is currently being developed as an alternative to the Multi-Mission Radioisotope Thermoelectric Generator (MMRTG). Power sources such as these may be needed for proposed missions to solar system planets and bodies that have challenging Planetary Protection (PP) requirements (e.g. Mars, Europa, Enceladus) that may support NASA s search for life, remnants of past life, and the precursors of life. One concern is that the heat from the ASRG could potentially create a region in which liquid water may occur. As advised by the NASA Planetary Protection Officer, when deploying an ASRG to Mars, the current COSPAR/NASA PP policy should be followed for Category IVc mission. Thus, sterilization processing of the ASRG to achieve bioburden reduction would be essential to meet the Planetary Protection requirements. Due to thermal constraints and associated low temperature limits of elements of the ASRG, vapor hydrogen peroxide (VHP) was suggested as a candidate alternative sterilization process to complement dry heat microbial reduction (DHMR) for the assembled ASRG. The following proposed sterilization plan for the ASRG anticipates a mission Category IVc level of cleanliness. This plan provides a scenario in which VHP is used as the final sterilization process. Keywords: Advanced Stirling Radioisotope Generator (ASRG), Planetary Protection (PP), Vapor hydrogen peroxide (VHP) sterilization.

  2. Space vehicle integrated thermal protection/structural/meteoroid protection system, volume 1

    NASA Technical Reports Server (NTRS)

    Bartlett, D. H.; Zimmerman, D. K.

    1973-01-01

    A program was conducted to determine the merit of a combined structure/thermal meteoroid protection system for a cryogenic vehicle propulsion module. Structural concepts were evaluated to identify least weight designs. Thermal analyses determined optimum tank arrangements and insulation materials. Meteoroid penetration experiments provided data for design of protection systems. Preliminary designs were made and compared on the basis of payload capability. Thermal performance tests demonstrated heat transfer rates typical for the selected design. Meteoroid impact tests verified the protection characteristics. A mockup was made to demonstrate protection system installation. The best design found combined multilayer insulation with a truss structure vehicle body. The multilayer served as the thermal/meteoroid protection system.

  3. Immobilization of alkaline phosphatase on solid surface through self-assembled monolayer and by active-site protection.

    PubMed

    Gao, En-Feng; Kang, Kyung Lhi; Kim, Jeong Hee

    2014-06-01

    Retaining biological activity of a protein after immobilization is an important issue and many studies reported to enhance the activity of proteins after immobilization. We recently developed a new immobilization method of enzyme using active-site protection and minimization of the cross-links between enzyme and surface with a DNA polymerase as a model system. In this study, we extended the new method to an enzyme with a small mono-substrate using alkaline phosphatase (AP) as another model system. A condition to apply the new method is that masking agents, in this case its own substrate needs to stay at the active-site of the enzyme to be immobilized in order to protect the active-site during the harsh immobilization process. This could be achieved by removal of essential divalent ion, Zn2+ that is required for full enzyme activity of AP from the masking solution while active-site of AP was protected with p-nitrophenyl phosphate (pNPP). Approximately 40% of the solution-phase activity was acquired with active-site protected immobilized AP. In addition to protection active-site of AP, the number of immobilization links was kinetically controlled. When the mole fraction of the activated carboxyl group of the linker molecule in self-assembled monolayer (SAM) of 12-mercaptododecanoic acid and 6-mercapto-1-ethanol was varied, 10% of 12-mercaptododecanoic acid gave the maximum enzyme activity. Approximately 51% increase in enzyme activity of the active-site protected AP was observed compared to that of the unprotected group. It was shown that the concept of active-site protection and kinetic control of the number of covalent immobilization bonds can be extended to enzymes with small mono-substrates. It opens the possibility of further extension of the new methods of active-site protection and kinetic control of immobilization bond to important enzymes used in research and industrial fields.

  4. Systemic Inhibition of NF-κB Activation Protects from Silicosis

    PubMed Central

    Di Giuseppe, Michelangelo; Gambelli, Federica; Hoyle, Gary W.; Lungarella, Giuseppe; Studer, Sean M.; Richards, Thomas; Yousem, Sam; McCurry, Ken; Dauber, James; Kaminski, Naftali; Leikauf, George; Ortiz, Luis A.

    2009-01-01

    Background Silicosis is a complex lung disease for which no successful treatment is available and therefore lung transplantation is a potential alternative. Tumor necrosis factor alpha (TNFα) plays a central role in the pathogenesis of silicosis. TNFα signaling is mediated by the transcription factor, Nuclear Factor (NF)-κB, which regulates genes controlling several physiological processes including the innate immune responses, cell death, and inflammation. Therefore, inhibition of NF-κB activation represents a potential therapeutic strategy for silicosis. Methods/Findings In the present work we evaluated the lung transplant database (May 1986–July 2007) at the University of Pittsburgh to study the efficacy of lung transplantation in patients with silicosis (n = 11). We contrasted the overall survival and rate of graft rejection in these patients to that of patients with idiopathic pulmonary fibrosis (IPF, n = 79) that was selected as a control group because survival benefit of lung transplantation has been identified for these patients. At the time of lung transplantation, we found the lungs of silica-exposed subjects to contain multiple foci of inflammatory cells and silicotic nodules with proximal TNFα expressing macrophage and NF-κB activation in epithelial cells. Patients with silicosis had poor survival (median survival 2.4 yr; confidence interval (CI): 0.16–7.88 yr) compared to IPF patients (5.3 yr; CI: 2.8–15 yr; p = 0.07), and experienced early rejection of their lung grafts (0.9 yr; CI: 0.22–0.9 yr) following lung transplantation (2.4 yr; CI:1.5–3.6 yr; p<0.05). Using a mouse experimental model in which the endotracheal instillation of silica reproduces the silica-induced lung injury observed in humans we found that systemic inhibition of NF-κB activation with a pharmacologic inhibitor (BAY 11-7085) of IκBα phosphorylation decreased silica-induced inflammation and collagen deposition. In contrast, transgenic mice expressing

  5. Planetary Protection Considerations for Life Support and Habitation Systems

    NASA Technical Reports Server (NTRS)

    Barta, Daniel J.; Hogan, John A.

    2010-01-01

    Life support systems for future human missions beyond low Earth orbit may include a combination of existing hardware components and advanced technologies. Discipline areas for technology development include atmosphere revitalization, water recovery, solid waste management, crew accommodations, food production, thermal systems, environmental monitoring, fire protection and radiation protection. Life support systems will be influenced by in situ resource utilization (ISRU), crew mobility and the degree of extravehicular activity. Planetary protection represents an additional set of requirements that technology developers have generally not considered. Planetary protection guidelines will affect the kind of operations, processes, and functions that can take place during future exploration missions, including venting and discharge of liquids and solids, ejection of wastes, use of ISRU, requirements for cabin atmospheric trace contaminant concentrations, cabin leakage and restrictions on what materials, organisms, and technologies that may be brought on missions. Compliance with planetary protection requirements may drive development of new capabilities or processes (e.g. in situ sterilization, waste containment, contaminant measurement) and limit or prohibit certain kinds of operations or processes (e.g. unfiltered venting). Ultimately, there will be an effect on mission costs, including the mission trade space. Planetary protection requirements need to be considered early in technology development programs. It is expected that planetary protection will have a major impact on technology selection for future missions.

  6. Data surveillance in child protection systems development: an Indonesian case study.

    PubMed

    Boothby, Neil; Stark, Lindsay

    2011-12-01

    Successful implementation of child protection program interventions and child and family welfare services is contingent upon the availability and use of good quality information, as emphasized by the recent Convention on the Rights of the Child's General Comment 13. Yet, the role of information within child protection is not well understood, and ongoing efforts to strengthen child protection systems have not systematically examined this critical function. Recognizing these shortcomings, the Government of Indonesia and UNICEF commissioned a study to identify a "road map" for a national child protection information system. The used desk review, semi-structured interviews, focus groups and site visits to identify existing data collection practices, and analyze the appropriateness and efficiency of information management mechanisms from the national down to the community level. The results show that the prevailing situation in Indonesia is characterized by a lack of accurate information on all necessary aspects of child care and protection including magnitude of problems, causality analysis and impact of programmatic responses. There is no lead actor for child protection at the national level, and there are no agreed upon data collection priorities, procedures or methods for a shared data collection system. The study suggests a need to reframe the dominant language from a "child protection information management system" to a "child protection surveillance system" to promote clearer data collection objectives and activities. Identifying a government ministry to lead child protection efforts and to forge closer partnerships among relevant actors will be required to support a national surveillance system. Additionally, addressing obstacles that limit child protection incident detection at the community level is critical. In addition to strengthening Indonesia's system, this study's approach and findings have the potential to help to inform ongoing child protection system

  7. A fuselage/tank structure study for actively cooled hypersonic cruise vehicles: Active cooling system analysis

    NASA Technical Reports Server (NTRS)

    Stone, J. E.

    1975-01-01

    The effects of fuselage cross section and structural arrangement on the performance of actively cooled hypersonic cruise vehicles are investigated. An active cooling system which maintains the aircraft's entire surface area at temperatures below 394 K at Mach 6 is developed along with a hydrogen fuel tankage thermal protection system. Thermodynamic characteristics of the actively cooled thermal protection systems established are summarized. Design heat loads and coolant flowrate requirements are defined for each major structural section and for the total system. Cooling system weights are summarized at the major component level. Conclusions and recommendations are included.

  8. Implementation Of Conservation Policy Through The Protection Of Life Support System In The Karimunjawa National Park

    NASA Astrophysics Data System (ADS)

    Ariyani, Nur Anisa Eka; Kismartini

    2018-02-01

    The Karimunjawa National Park as the only one marine protected area in Central Java, managed by zonation system has decreased natural resources in the form of decreasing mangrove forest area, coral cover, sea biota population such as clams and sea cucumbers. Conservation has been done by Karimunjawa National Park Authority through protection of life support system activities in order to protect the area from degradation. The objective of the research is to know the implementation of protection and security activities of Karimunjawa National Park Authority for the period of 2012 - 2016. The research was conducted by qualitative method, processing secondary data from Karimunjawa National Park Authority and interview with key informants. The results showed that protection and security activities in The Karimunjawa National Park were held with three activities: pre-emptive activities, preventive activities and repressive activities. Implementation of conservation policy through protection of life support system is influenced by factors of policy characteristic, resource factor and environmental policy factor. Implementation of conservation policy need support from various parties, not only Karimunjawa National Park Authority as the manager of the area, but also need participation of Jepara Regency, Central Java Provinces, communities, NGOs, researchers, developers and tourism actors to maintain and preserve existing biodiversity. Improving the quality of implementors through education and training activities, the availability of the state budget annually and the support of stakeholders is essential for conservation.

  9. Advanced power system protection and incipient fault detection and protection of spaceborne power systems

    NASA Technical Reports Server (NTRS)

    Russell, B. Don

    1989-01-01

    This research concentrated on the application of advanced signal processing, expert system, and digital technologies for the detection and control of low grade, incipient faults on spaceborne power systems. The researchers have considerable experience in the application of advanced digital technologies and the protection of terrestrial power systems. This experience was used in the current contracts to develop new approaches for protecting the electrical distribution system in spaceborne applications. The project was divided into three distinct areas: (1) investigate the applicability of fault detection algorithms developed for terrestrial power systems to the detection of faults in spaceborne systems; (2) investigate the digital hardware and architectures required to monitor and control spaceborne power systems with full capability to implement new detection and diagnostic algorithms; and (3) develop a real-time expert operating system for implementing diagnostic and protection algorithms. Significant progress has been made in each of the above areas. Several terrestrial fault detection algorithms were modified to better adapt to spaceborne power system environments. Several digital architectures were developed and evaluated in light of the fault detection algorithms.

  10. Towards an Active Hearing Protection Device for Musicians =

    NASA Astrophysics Data System (ADS)

    Bernier, Antoine

    Professional musicians are oftentimes exposed to high levels of sound. Prolonged or severe exposure to high sound levels could lead to permanent hearing loss and compromise their career. The logical solution would be to wear hearing protection devices (HPDs) when appropriate. However, perceptual discomfort associated with wearing HPD can discourage their use by musicians. The perceptual discomfort is caused by two detrimental effects: the occlusion effect and the isolation effect. The occlusion effect is often reported as an augmented, unnatural and annoying perception of one's own voice or instrument mechanically coupled to the head when wearing HPDs. The isolation effect is the unnatural sensation of being isolated from a given sound environment and can be caused by wearing HPDs that do not compensate for psychoacoustical factors and therefore alter the wearer's auditory perception. Both effects are highly unfavorable to the musicians' auditory perception and compromise their capacity to perform to the best of their abilities for their audience. They are among the reasons most often reported by musicians to decide not to wear HPDs. This master's project presents the concept and first prototype of an active HPD for musicians that aims at solving the detrimental effects while protecting the musician's hearing. A solution for the occlusion effect is presented in the form of an earplug complemented with in-ear active noise control. Practical design issues and required trade-off are analyzed through a literature review and the implementation and characterization of an active occlusion effect reduction system, allowing reduction of the occlusion effect between 8.5 and 12 dB at 250 Hz. A solution for the isolation effect is presented in the form of an earplug complemented with digital signal processing capabilities. Factors that may cause the isolation effect are identified through a literature review and corresponding algorithms that aim at re-establishing the

  11. Nitroxide delivery system for Nrf2 activation and skin protection.

    PubMed

    Ben Yehuda Greenwald, Maya; Frušić-Zlotkin, Marina; Soroka, Yoram; Sasson, Shmuel Ben; Bianco-Peled, Havazelet; Bitton, Ronit; Kohen, Ron

    2015-08-01

    Cyclic nitroxides are a large group of compounds composed of diverse stable radicals also known as synthetic antioxidants. Although nitroxides are valuable for use in several skin conditions, in in vivo conditions they have several drawbacks, such as nonspecific dispersion in normal tissue, preferential renal clearance and rapid reduction of the nitroxide to the corresponding hydroxylamine. However, these drawbacks can be easily addressed by encapsulating the nitroxides within microemulsions. This approach would allow nitroxide activity and therefore their valuable effects (e.g. activation of the Keap1-Nrf2-EpRE pathway) to continue. In this work, nitroxides were encapsulated in a microemulsion composed of biocompatible ingredients. The nanometric size and shape of the vehicle microemulsion and nitroxide microemulsion displayed high similarity, indicating that the stability of the microemulsions was preserved. Our studies demonstrated that nitroxide microemulsions were more potent inducers of the Keap1-Nrf2-EpRE pathway than the free nitroxides, causing the activation of phase II enzymes. Moreover, microemulsions containing nitroxides significantly reduced UVB-induced cytotoxicity in the skin. Understanding the mechanism of this improved activity may expand the usage of many other Nrf2 modulating molecules in encapsulated form, as a skin protection strategy against oxidative stress-related conditions. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. Advanced worker protection system. Topical report, Phase I

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Myers, J.

    1995-07-01

    The Department of Energy (DOE) is in the process of defining the magnitude and diversity of Decontamination and Decommissioning (D&D) obligations at its numerous sites. The DOE believes that existing technologies are inadequate to solve many challenging problems such as how to decontaminate structures and equipment cost effectively, what to do with materials and wastes generated, and how to adequately protect workers and the environment. Preliminary estimates show a tremendous need for effective use of resources over a relatively long period (over 30 years). Several technologies are being investigated which can potentially reduce D&D costs while providing appropriate protection tomore » DOE workers. The DOE recognizes that traditional methods used by the EPA in hazardous waste site clean up activities are insufficient to provide the needed protection and worker productivity demanded by DOE D&D programs. As a consequence, new clothing and equipment which can adequately protect workers while providing increases in worker productivity are being sought for implementation at DOE sites. This project will result in the development of an Advanced Worker Protection System (AWPS). The AWPS will be built around a life support backpack that uses liquid air to provide cooling as well as breathing gas to the worker. The backpack will be combined with advanced protective garments, advanced liquid cooling garment, respirator, communications, and support equipment to provide improved worker protection, simplified system, maintenance, and dramatically improve worker productivity through longer duration work cycles.« less

  13. 42 CFR 51.31 - Conduct of protection and advocacy activities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... to mental health system improvement. Decisions concerning the selection of individuals to receive... 42 Public Health 1 2010-10-01 2010-10-01 false Conduct of protection and advocacy activities. 51.31 Section 51.31 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS...

  14. Effects of pituitary adenylate cyclase activating polypeptide in the urinary system, with special emphasis on its protective effects in the kidney.

    PubMed

    Reglodi, Dora; Kiss, Peter; Horvath, Gabriella; Lubics, Andrea; Laszlo, Eszter; Tamas, Andrea; Racz, Boglarka; Szakaly, Peter

    2012-04-01

    Pituitary adenylate cyclase activating polypeptide (PACAP) is a widespread neuropeptide with diverse effects in the nervous system and peripheral organs. One of the most well-studied effects of PACAP is its cytoprotective action, against different harmful stimuli in a wide variety of cells and tissues. PACAP occurs in the urinary system, from the kidney to the lower urinary tract. The present review focuses on the nephroprotective effects of PACAP and summarizes data obtained regarding the protective effects of PACAP in different models of kidney pathologies. In vitro data show that PACAP protects tubular cells against oxidative stress, myeloma light chain, cisplatin, cyclosporine-A and hypoxia. In vivo data provide evidence for its protective effects in ischemia/reperfusion, cisplatin, cyclosporine-A, myeloma kidney injury, diabetic nephropathy and gentamicin-induced kidney damage. Results accumulated on the renoprotective effects of PACAP suggest that PACAP is an emerging candidate for treatment of human kidney pathologies. Copyright © 2011 Elsevier Ltd. All rights reserved.

  15. L-3 Com AVISYS civil aviation self-protection system

    NASA Astrophysics Data System (ADS)

    Carey, Jim

    2006-05-01

    In early 2004, L-3 Com AVISYS Corporation (hereinafter referred to as L-3 AVISYS or AVISYS) completed a contract for the integration and deployment of an advanced Infrared Countermeasures self-protection suite for a Head of State Airbus A340 aircraft. This initial L-3 AVISYS IRCM Suite was named WIPPS (Widebody Integrated Platform Protection System). The A340 WIPPS installation provisions were FAA certified with the initial deployment of the modified aircraft. WIPPS is unique in that it utilizes a dual integrated missile warning subsystem to produce a robust, multi-spectral, ultra-low false alarm rate threat warning capability. WIPPS utilizes the Thales MWS-20 Pulsed Doppler Radar Active MWS and the EADS AN/AAR-60 Ultraviolet Passive MWS. These MWS subsystems are integrated through an L-3 AVISYS Electronic Warfare Control Set (EWCS). The EWCS also integrates the WIPPS MWS threat warning information with the A340 flight computer data to optimize ALE-47 Countermeasure Dispensing System IR decoy dispensing commands, program selection and timing. WIPPS utilizes standard and advanced IR Decoys produced by ARMTEC Defense and Alloy Surfaces. WIPPS demonstrated that when IR decoy dispensing is controlled by threat range and time-to-go information provided by an Active MWS, unsurpassed self protection levels are achievable. Recognizing the need for high volume civil aviation protection, L-3 AVISYS configured a variant of WIPPS optimized for commercial airline reliability requirements, safety requirements, supportability and most importantly, affordability. L-3 AVISYS refers to this IRCM suite as CAPS (Commercial Airliner Protection System). CAPS has been configured for applications to all civil aircraft ranging from the small Regional Jets to the largest Wide-bodies. This presentation and paper will provide an overview of the initial WIPPS IRCM Suite and the important factors that were considered in defining the CAPS configuration.

  16. Multiwall thermal protection system

    NASA Technical Reports Server (NTRS)

    Jackson, L. R. (Inventor)

    1982-01-01

    Multiwall insulating sandwich panels are provided for thermal protection of hypervelocity vehicles and other enclosures. In one embodiment, the multiwall panels are formed of alternate layers of dimpled and flat metal (titanium alloy) foil sheets and beaded scarfed edge seals to provide enclosure thermal protection up to 1000 F. An additional embodiment employs an intermediate fibrous insulation for the sandwich panel to provide thermal protection up to 2000 F. A third embodiment employs a silicide coated columbium waffle as the outer panel skin and fibrous layered intermediate protection for thermal environment protection up to 2500 F. The use of multiple panels on an enclosure facilitate repair and refurbishment of the thermal protection system due to the simple support provided by the tab and clip attachment for the panels.

  17. Thermal protection system and related methods

    NASA Technical Reports Server (NTRS)

    Garbe, Duane J. (Inventor)

    2012-01-01

    A thermal protection system and a method of manufacturing are disclosed. The thermal protection system may be configured to protect a movable joint, for example, a flexible bearing of a rocket motor nozzle. The thermal protection system includes a series of annular shims separated by a plurality of discrete spacers. Each shim of the series of annular shims may have a larger diameter than the previous shim, and the shims may nest. The shims may comprise a thermally stable material, and the discrete spacers may comprise an elastomer. Optionally, an annular bearing protector may separate the annular shims from the flexible bearing.

  18. 21 CFR 347.10 - Skin protectant active ingredients.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) DRUGS FOR HUMAN USE SKIN PROTECTANT DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE Active Ingredients § 347.10 Skin protectant active ingredients. The active ingredients of the product consist of any of the...) Aluminum hydroxide gel, 0.15 to 5 percent. (c) Calamine, 1 to 25 percent. (d) Cocoa butter, 50 to 100...

  19. Flight set 360L007 (STS-33R) field joint protection system, thermal protection system, and systems tunnel components, volume 7

    NASA Technical Reports Server (NTRS)

    1990-01-01

    The performance of the thermal protection system, field joint protection system, and systems tunnel components of flight set 360L007 is presented as evaluated by postflight hardware inspection. The condition of both motors was similar to previous flights. Four aft edge strikes were noted on the ground environment instrumentation thermal protection system. The hits all left a clean substrate, indicating that the damage was caused by nozzle severance debris and/or water impact. No National Space Transportation System debris criteria for missing thermal protection system were violated. Two problem reports were written against the field joint protection system. The first concerned two cracks in the K5NA closeout over the trunnion/vent valve location on the left-hand aft field joint. A similar condition was observed on Flight 5 (360H005). The second problem report referred to a number of small surface cracks between two impact marks on the left-hand forward field joint. Neither area exhibited loose material or any abnormal heat effects, and they have no impact on flight safety.

  20. Protective-antigen (PA) based anthrax vaccines confer protection against inhalation anthrax by precluding the establishment of a systemic infection

    PubMed Central

    Merkel, Tod J; Perera, Pin-Yu; Lee, Gloria M; Verma, Anita; Hiroi, Toyoko; Yokote, Hiroyuki; Waldmann, Thomas A; Perera, Liyanage P

    2013-01-01

    An intense effort has been launched to develop improved anthrax vaccines that confer rapid, long lasting protection preferably with an extended stability profile amenable for stockpiling. Protective antigen (PA)-based vaccines are most favored as immune responses directed against PA are singularly protective, although the actual protective mechanism remains to be unraveled. Herein we show that contrary to the prevailing view, an efficacious PA-based vaccine confers protection against inhalation anthrax by preventing the establishment of a toxin-releasing systemic infection. Equally importantly, antibodies measured by the in vitro lethal toxin neutralization activity assay (TNA) that is considered as a reliable correlate of protection, especially for PA protein-based vaccines adjuvanted with aluminum salts appear to be not absolutely essential for this protective immune response. PMID:23787486

  1. Protective-antigen (PA) based anthrax vaccines confer protection against inhalation anthrax by precluding the establishment of a systemic infection.

    PubMed

    Merkel, Tod J; Perera, Pin-Yu; Lee, Gloria M; Verma, Anita; Hiroi, Toyoko; Yokote, Hiroyuki; Waldmann, Thomas A; Perera, Liyanage P

    2013-09-01

    An intense effort has been launched to develop improved anthrax vaccines that confer rapid, long lasting protection preferably with an extended stability profile amenable for stockpiling. Protective antigen (PA)-based vaccines are most favored as immune responses directed against PA are singularly protective, although the actual protective mechanism remains to be unraveled. Herein we show that contrary to the prevailing view, an efficacious PA-based vaccine confers protection against inhalation anthrax by preventing the establishment of a toxin-releasing systemic infection. Equally importantly, antibodies measured by the in vitro lethal toxin neutralization activity assay (TNA) that is considered as a reliable correlate of protection, especially for PA protein-based vaccines adjuvanted with aluminum salts appear to be not absolutely essential for this protective immune response.

  2. Exercise protects the cardiovascular system: effects beyond traditional risk factors

    PubMed Central

    Joyner, Michael J; Green, Daniel J

    2009-01-01

    In humans, exercise training and moderate to high levels of physical activity are protective against cardiovascular disease. In fact they are ∼40% more protective than predicted based on the changes in traditional risk factors (blood lipids, hypertension, diabetes etc.) that they cause. In this review, we highlight the positive effects of exercise on endothelial function and the autonomic nervous system. We also ask if these effects alone, or in combination, might explain the protective effects of exercise against cardiovascular disease that appear to be independent of traditional risk factor modification. Our goal is to use selected data from our own work and that of others to stimulate debate on the nature and cause of the ‘risk factor gap’ associated with exercise and physical activity. PMID:19736305

  3. Food protection activities of the Pan American Health Organization.

    PubMed

    1994-03-01

    One of the most widespread health problems in the Caribbean and Latin America is contaminated food and foodborne illness. The Pan American Health Organization (PAHO) has been a major force in activities to strengthen food protection. The program within the regional Program of Technical Cooperation is administered by the Veterinary Public Health program and under the guidance of the Pan American Institute for Food protection and Zoonoses in Buenos Aires, Argentina. A food action plan for 1986-90 was established at the 1986 Pan American Sanitary Conference, and extended to cover 1991-95. Program activities during the 1990s covered cholera, epidemiologic surveillance, street food vendors, shellfish poisoning, meat, national programs, information systems, air catering, food irradiation, and tourism. The action plan for 1991-95 promoted greater political support and cooperation within and between related sectors and institutions, management, and education. The aims were to organize national integrated programs, to strengthen laboratory services, to strengthen inspection services, to establish epidemiologic surveillance systems, and to promote food protection through community participation. Program activities included the initiatives of the Veterinary Public Health Program in 1991 to distribute literature on the transmission of cholera by foods. Studies were conducted in Bolivia, Colombia, and Peru on food contamination. Microbiologists received training on standard methods for detecting Vibrio cholerae in foods. A working group of experts from 10 countries examined the issues and produced a guide for investigating the incidence of foodborne disease. PAHO has contributed to the formation of an Inter-American Network for Epidemiologic Surveillance of Foodborne Diseases. PAHO has worked to improve hygienic practices among street food vendors. Seminars on paralytic shellfish poisoning were conducted in 1990; the outcome was a network working to strengthen national

  4. Control and protection system for paralleled modular static inverter-converter systems

    NASA Technical Reports Server (NTRS)

    Birchenough, A. G.; Gourash, F.

    1973-01-01

    A control and protection system was developed for use with a paralleled 2.5-kWe-per-module static inverter-converter system. The control and protection system senses internal and external fault parameters such as voltage, frequency, current, and paralleling current unbalance. A logic system controls contactors to isolate defective power conditioners or loads. The system sequences contactor operation to automatically control parallel operation, startup, and fault isolation. Transient overload protection and fault checking sequences are included. The operation and performance of a control and protection system, with detailed circuit descriptions, are presented.

  5. DNA-protective activities of hyperforin and aristoforin.

    PubMed

    Ševčovičová, A; Šemeláková, M; Plšíková, J; Loderer, D; Imreová, P; Gálová, E; Kožurková, M; Miadoková, E; Fedoročko, P

    2015-04-01

    The aim of this study was to explain the molecular mechanisms of action of hyperforin, a phluoroglucinol derivative found in Hypericum perforatum L. and its more stable derivative aristoforin. DNA-topology assay revealed partial DNA-protective activities of hyperforin and aristoforin against Fe(2+)-induced DNA breaks. In order to assess molecular mechanisms underlying DNA-protective activity, the potential antioxidant activity of hyperforin and aristoforin was investigated using DPPH and OH scavenging assays, reducing power assay and Fe(2+)-chelating assay. We also studied interaction of hyperforin and aristoforin with DNA using established protocols for fluorescence titration. The ability of the studied compounds to relax topoisomerase I with electrophoretic techniques was investigated. The reduction in the fluorescence of hyperforin indicated an interaction between hyperforin and DNA with a binding constant of 0.2×10(8)M(-1). We suggest that a mechanism of hyperforin/aristoforin DNA-protective abilities is based on free radicals (mainly OH) scavenging activity. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. Integration of planetary protection activities

    NASA Technical Reports Server (NTRS)

    Race, Margaret S.

    1995-01-01

    For decades, NASA has been concerned about the protection of planets and other solar system bodies from biological contamination. Its policies regarding biological contamination control for outbound and inbound planetary spacecraft have evolved to focus on three important areas: (1) the preservation of celestial objects and the space environment; (2) protection of Earth from extraterrestrial hazards; and (3) ensuring the integrity of its scientific investigations. Over the years as new information has been obtained from planetary exploration and research, planetary protection parameters and policies have been modified accordingly. The overall focus of research under this cooperative agreement has been to provide information about non-scientific and societal factors related to planetary protection and use it in the planning and implementation phases of future Mars sample return missions.

  7. 32 CFR 228.2 - Control of activities on protected property.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Control of activities on protected property. 228... DEFENSE (CONTINUED) MISCELLANEOUS SECURITY PROTECTIVE FORCE § 228.2 Control of activities on protected property. Persons in and on protected property shall at all times comply with official signs of a...

  8. 32 CFR 228.2 - Control of activities on protected property.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Control of activities on protected property. 228... DEFENSE (CONTINUED) MISCELLANEOUS SECURITY PROTECTIVE FORCE § 228.2 Control of activities on protected property. Persons in and on protected property shall at all times comply with official signs of a...

  9. 32 CFR 228.2 - Control of activities on protected property.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Control of activities on protected property. 228... DEFENSE (CONTINUED) MISCELLANEOUS SECURITY PROTECTIVE FORCE § 228.2 Control of activities on protected property. Persons in and on protected property shall at all times comply with official signs of a...

  10. 32 CFR 228.2 - Control of activities on protected property.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Control of activities on protected property. 228... DEFENSE (CONTINUED) MISCELLANEOUS SECURITY PROTECTIVE FORCE § 228.2 Control of activities on protected property. Persons in and on protected property shall at all times comply with official signs of a...

  11. 78 FR 77574 - Protection System Maintenance Reliability Standard

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... protection system component type, except that the maintenance program for all batteries associated with the... Electric System reliability and promoting efficiency through consolidation [of protection system-related... ITC that PRC-005-2 promotes efficiency by consolidating protection system maintenance requirements...

  12. European Directions for Hypersonic Thermal Protection Systems and Hot Structures

    NASA Technical Reports Server (NTRS)

    Glass, David E.

    2007-01-01

    This presentation will overview European Thermal Protection Systems (TPS) and Hot Structures activities in Europe. The Europeans have a lot of very good work going on in the area. The presentation will discuss their emphasis on focused technology development for their flight vehicles.

  13. Integration of Planetary Protection Activities

    NASA Technical Reports Server (NTRS)

    Race, Margaret S.

    2000-01-01

    Research and activities under this grant have focused on a systematic examination and analysis of critical questions likely to impact planetary protection (PP) controls and implementation for Mars sample return missions (MSR). Four areas in the non-scientific and social realms were selected for special attention because of their importance to future mission planning and concern about critical timing or possible economic impacts on MSR mission implementation. These include: (1) questions of legal uncertainty and the decision making process, (2) public perception of risks associated with sample return, (3) risk communication and Education/Public Outreach , and (4) planetary protection implications of alternative mission architectures, for both robotic and human sample return missions. In its entirety, NAG 2-986 has encompassed three categories of activity: (1) research and analysis (Race), (2) subcontracted research (MacGregor/Decision Research), and (3) consulting services.

  14. Is lipid signaling through cannabinoid 2 receptors part of a protective system?

    PubMed Central

    Pacher, P.; Mechoulam, R.

    2011-01-01

    The mammalian body has a highly developed immune system which guards against continuous invading protein attacks and aims at preventing, attenuating or repairing the inflicted damage. It is conceivable that through evolution analogous biological protective systems have been evolved against non-protein attacks. There is emerging evidence that lipid endocannabinoid signaling through cannabinoid 2 (CB2) receptors may represent an example/part of such a protective system/armamentarium. Inflammation/tissue injury triggers rapid elevations in local endocannabinoid levels, which in turn regulate signaling responses in immune and other cells modulating their critical functions. Changes in endocannabinoid levels and/or CB2 receptor expressions have been reported in almost all diseases affecting humans, ranging from cardiovascular, gastrointestinal, liver, kidney, neurodegenerative, psychiatric, bone, skin, auto-immune, lung disorders to pain and cancer, and modulating CB2 receptor activity holds tremendous therapeutic potential in these pathologies. While CB2 receptor activation in general mediates immunosuppressive effects, which limit inflammation and associated tissue injury in large number of pathological conditions, in some disease states activation of the CB2 receptor may enhance or even trigger tissue damage, which will also be discussed alongside the protective actions of the CB2 receptor stimulation with endocannabinoids or synthetic agonists, and the possible biological mechanisms involved in these effects. PMID:21295074

  15. Is lipid signaling through cannabinoid 2 receptors part of a protective system?

    PubMed

    Pacher, P; Mechoulam, R

    2011-04-01

    The mammalian body has a highly developed immune system which guards against continuous invading protein attacks and aims at preventing, attenuating or repairing the inflicted damage. It is conceivable that through evolution analogous biological protective systems have been evolved against non-protein attacks. There is emerging evidence that lipid endocannabinoid signaling through cannabinoid 2 (CB₂) receptors may represent an example/part of such a protective system/armamentarium. Inflammation/tissue injury triggers rapid elevations in local endocannabinoid levels, which in turn regulate signaling responses in immune and other cells modulating their critical functions. Changes in endocannabinoid levels and/or CB₂ receptor expressions have been reported in almost all diseases affecting humans, ranging from cardiovascular, gastrointestinal, liver, kidney, neurodegenerative, psychiatric, bone, skin, autoimmune, lung disorders to pain and cancer, and modulating CB₂ receptor activity holds tremendous therapeutic potential in these pathologies. While CB₂ receptor activation in general mediates immunosuppressive effects, which limit inflammation and associated tissue injury in large number of pathological conditions, in some disease states activation of the CB₂ receptor may enhance or even trigger tissue damage, which will also be discussed alongside the protective actions of the CB₂ receptor stimulation with endocannabinoids or synthetic agonists, and the possible biological mechanisms involved in these effects. Published by Elsevier Ltd.

  16. Integral isolation valve systems for loss of coolant accident protection

    DOEpatents

    Kanuch, David J.; DiFilipo, Paul P.

    2018-03-20

    A nuclear reactor includes a nuclear reactor core comprising fissile material disposed in a reactor pressure vessel having vessel penetrations that exclusively carry flow into the nuclear reactor and at least one vessel penetration that carries flow out of the nuclear reactor. An integral isolation valve (IIV) system includes passive IIVs each comprising a check valve built into a forged flange and not including an actuator, and one or more active IIVs each comprising an active valve built into a forged flange and including an actuator. Each vessel penetration exclusively carrying flow into the nuclear reactor is protected by a passive IIV whose forged flange is directly connected to the vessel penetration. Each vessel penetration carrying flow out of the nuclear reactor is protected by an active IIV whose forged flange is directly connected to the vessel penetration. Each active valve may be a normally closed valve.

  17. Mesoporous silica nanoparticles for active corrosion protection.

    PubMed

    Borisova, Dimitriya; Möhwald, Helmuth; Shchukin, Dmitry G

    2011-03-22

    This work presents the synthesis of monodisperse, mesoporous silica nanoparticles and their application as nanocontainers loaded with corrosion inhibitor (1H-benzotriazole (BTA)) and embedded in hybrid SiOx/ZrOx sol-gel coating for the corrosion protection of aluminum alloy. The developed porous system of mechanically stable silica nanoparticles exhibits high surface area (∼1000 m2·g(-1)), narrow pore size distribution (d∼3 nm), and large pore volume (∼1 mL·g(-1)). As a result, a sufficiently high uptake and storage of the corrosion inhibitor in the mesoporous nanocontainers was achieved. The successful embedding and homogeneous distribution of the BTA-loaded monodisperse silica nanocontainers in the passive anticorrosive SiOx/ZrOx film improve the wet corrosion resistance of the aluminum alloy AA2024 in 0.1 M sodium chloride solution. The enhanced corrosion protection of this newly developed active system in comparison to the passive sol-gel coating was observed during a simulated corrosion process by the scanning vibrating electrode technique (SVET). These results, as well as the controlled pH-dependent release of BTA from the mesoporous silica nanocontainers without additional polyelectrolyte shell, suggest an inhibitor release triggered by the corrosion process leading to a self-healing effect.

  18. 78 FR 44475 - Protection System Maintenance Reliability Standard

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... Protection System Maintenance--Phase 2 (Reclosing Relays)). 12. NERC states that the proposed Reliability... of the relay inputs and outputs that are essential to proper functioning of the protection system...] Protection System Maintenance Reliability Standard AGENCY: Federal Energy Regulatory Commission, Energy...

  19. Advanced Protection & Service Restoration for FREEDM Systems

    NASA Astrophysics Data System (ADS)

    Singh, Urvir

    A smart electric power distribution system (FREEDM system) that incorporates DERs (Distributed Energy Resources), SSTs (Solid State Transformers - that can limit the fault current to two times of the rated current) & RSC (Reliable & Secure Communication) capabilities has been studied in this work in order to develop its appropriate protection & service restoration techniques. First, a solution is proposed that can make conventional protective devices be able to provide effective protection for FREEDM systems. Results show that although this scheme can provide required protection but it can be quite slow. Using the FREEDM system's communication capabilities, a communication assisted Overcurrent (O/C) protection scheme is proposed & results show that by using communication (blocking signals) very fast operating times are achieved thereby, mitigating the problem of conventional O/C scheme. Using the FREEDM System's DGI (Distributed Grid Intelligence) capability, an automated FLISR (Fault Location, Isolation & Service Restoration) scheme is proposed that is based on the concept of 'software agents' & uses lesser data (than conventional centralized approaches). Test results illustrated that this scheme is able to provide a global optimal system reconfiguration for service restoration.

  20. 14 CFR 23.1359 - Electrical system fire protection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Electrical system fire protection. 23.1359... Electrical Systems and Equipment § 23.1359 Electrical system fire protection. (a) Each component of the electrical system must meet the applicable fire protection requirements of §§ 23.863 and 23.1182. (b...

  1. 14 CFR 23.1359 - Electrical system fire protection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Electrical system fire protection. 23.1359... Electrical Systems and Equipment § 23.1359 Electrical system fire protection. (a) Each component of the electrical system must meet the applicable fire protection requirements of §§ 23.863 and 23.1182. (b...

  2. 14 CFR 23.1359 - Electrical system fire protection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Electrical system fire protection. 23.1359... Electrical Systems and Equipment § 23.1359 Electrical system fire protection. (a) Each component of the electrical system must meet the applicable fire protection requirements of §§ 23.863 and 23.1182. (b...

  3. 14 CFR 23.1359 - Electrical system fire protection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Electrical system fire protection. 23.1359... Electrical Systems and Equipment § 23.1359 Electrical system fire protection. (a) Each component of the electrical system must meet the applicable fire protection requirements of §§ 23.863 and 23.1182. (b...

  4. 14 CFR 23.1359 - Electrical system fire protection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Electrical system fire protection. 23.1359... Electrical Systems and Equipment § 23.1359 Electrical system fire protection. (a) Each component of the electrical system must meet the applicable fire protection requirements of §§ 23.863 and 23.1182. (b...

  5. 32 CFR 228.2 - Control of activities on protected property.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Control of activities on protected property. 228.2 Section 228.2 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS SECURITY PROTECTIVE FORCE § 228.2 Control of activities on protected...

  6. Collaborative Point Paper on Active Protection Systems

    DTIC Science & Technology

    2006-10-01

    for the Hunter VHP CIED Program. Also, General Dynamics Armament and Technical Products (GDATP), Burlington, VT is contracted by the Marine Corps...the incoming threat at a relatively long distance. Specific details about the composition and mechanism of this explosive interceptor device are...relatively thin shell of ballistic steel and composite armor, also known as hybrid armor, designed to provide optimal protection from specific threats

  7. Protecting peroxidase activity of multilayer enzyme-polyion films using outer catalase layers.

    PubMed

    Lu, Haiyun; Rusling, James F; Hu, Naifei

    2007-12-27

    Films constructed layer-by-layer on electrodes with architecture {protein/hyaluronic acid (HA)}n containing myoglobin (Mb) or horseradish peroxidase (HRP) were protected against protein damage by H2O2 by using outer catalase layers. Peroxidase activity for substrate oxidation requires activation by H2O2, but {protein/HA}n films without outer catalase layers are damaged slowly and irreversibly by H2O2. The rate and extent of damage were decreased dramatically by adding outer catalase layers to decompose H2O2. Comparative studies suggest that protection results from catalase decomposing a fraction of the H2O2 as it enters the film, rather than by an in-film diffusion barrier. The outer catalase layers controlled the rate of H2O2 entry into inner regions of the film, and they biased the system to favor electrocatalytic peroxide reduction over enzyme damage. Catalase-protected {protein/HA}n films had an increased linear concentration range for H2O2 detection. This approach offers an effective way to protect biosensors from damage by H2O2.

  8. Ethical foundations of the radiological protection system.

    PubMed

    Cho, K W

    2016-06-01

    The International Commission on Radiological Protection (ICRP) has established Task Group 94 under Committee 4 to develop a report on the ethical foundations of the system of radiological protection. The aim of this report is to consolidate the basis of ICRP recommendations, to improve understanding of the system, and to provide a basis for communication on radiation risk and its perception. Through a series of workshops organised by the Commission in cooperation with the International Radiation Protection Association and its associate societies involving radiological protection professionals and specialists of ethics around the world, Task Group 94 has identified the key ethical and social values underpinning the system of radiological protection. The purpose of eliciting the ethical principles and values of the radiological protection system is not only to clarify the rationale for recommendations made by the Commission, but also to assist in discussions related to its practical implementation. A clear understanding of the ethical principles will help resolve dilemmas caused by potential conflicts in actions that might be considered, or decisions that must be made. © The International Society for Prosthetics and Orthotics.

  9. Pressure Systems Energy Release Protection (Gas Pressurized Systems)

    NASA Technical Reports Server (NTRS)

    Brown, S. J. (Editor)

    1986-01-01

    A survey of studies into hazards associated with closed or pressurized system rupture and preliminary guidelines for the performance design of primary, secondary, and protective receptors of these hazards are provided. The hazards discussed in the survey are: blast, fragments, ground motion, heat radiation, biological, and chemical. Performance guidelines for receptors are limited to pressurized systems that contain inert gas. The performance guidelines for protection against the remaining unaddressed degenerative hazards are to be covered in another study.

  10. Foundations for Protecting Renewable-Rich Distribution Systems.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ellis, Abraham; Brahma, Sukumar; Ranade, Satish

    High proliferation of Inverter Interfaced Distributed Energy Resources (IIDERs) into the electric distribution grid introduces new challenges to protection of such systems. This is because the existing protection systems are designed with two assumptions: 1) system is single-sourced, resulting in unidirectional fault current, and (2) fault currents are easily detectable due to much higher magnitudes compared to load currents. Due to the fact that most renewables interface with the grid though inverters, and inverters restrict their current output to levels close to the full load currents, both these assumptions are no longer valid - the system becomes multi-sourced, and overcurrent-basedmore » protection does not work. The primary scope of this study is to analyze the response of a grid-tied inverter to different faults in the grid, leading to new guidelines on protecting renewable-rich distribution systems.« less

  11. Early infections by myxoma virus of young rabbits (Oryctolagus cuniculus) protected by maternal antibodies activate their immune system and enhance herd immunity in wild populations.

    PubMed

    Marchandeau, Stéphane; Pontier, Dominique; Guitton, Jean-Sébastien; Letty, Jérôme; Fouchet, David; Aubineau, Jacky; Berger, Francis; Léonard, Yves; Roobrouck, Alain; Gelfi, Jacqueline; Peralta, Brigitte; Bertagnoli, Stéphane

    2014-03-04

    The role of maternal antibodies is to protect newborns against acute early infection by pathogens. This can be achieved either by preventing any infection or by allowing attenuated infections associated with activation of the immune system, the two strategies being based on different cost/benefit ratios. We carried out an epidemiological survey of myxomatosis, which is a highly lethal infectious disease, in two distant wild populations of rabbits to describe the epidemiological pattern of the disease. Detection of specific IgM and IgG enabled us to describe the pattern of immunity. We show that maternal immunity attenuates early infection of juveniles and enables activation of their immune system. This mechanism associated with steady circulation of the myxoma virus in both populations, which induces frequent reinfections of immune rabbits, leads to the maintenance of high immunity levels within populations. Thus, myxomatosis has a low impact, with most infections being asymptomatic. This work shows that infection of young rabbits protected by maternal antibodies induces attenuated disease and activates their immune system. This may play a major role in reducing the impact of a highly lethal disease when ecological conditions enable permanent circulation of the pathogen.

  12. Early infections by myxoma virus of young rabbits (Oryctolagus cuniculus) protected by maternal antibodies activate their immune system and enhance herd immunity in wild populations

    PubMed Central

    2014-01-01

    The role of maternal antibodies is to protect newborns against acute early infection by pathogens. This can be achieved either by preventing any infection or by allowing attenuated infections associated with activation of the immune system, the two strategies being based on different cost/benefit ratios. We carried out an epidemiological survey of myxomatosis, which is a highly lethal infectious disease, in two distant wild populations of rabbits to describe the epidemiological pattern of the disease. Detection of specific IgM and IgG enabled us to describe the pattern of immunity. We show that maternal immunity attenuates early infection of juveniles and enables activation of their immune system. This mechanism associated with steady circulation of the myxoma virus in both populations, which induces frequent reinfections of immune rabbits, leads to the maintenance of high immunity levels within populations. Thus, myxomatosis has a low impact, with most infections being asymptomatic. This work shows that infection of young rabbits protected by maternal antibodies induces attenuated disease and activates their immune system. This may play a major role in reducing the impact of a highly lethal disease when ecological conditions enable permanent circulation of the pathogen. PMID:24589193

  13. 46 CFR 154.1110 - Areas protected by system.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Areas protected by system. 154.1110 Section 154.1110 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY... Firefighting § 154.1110 Areas protected by system. Each water spray system must protect: (a) All cargo tank...

  14. 46 CFR 154.1110 - Areas protected by system.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Areas protected by system. 154.1110 Section 154.1110 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY... Firefighting § 154.1110 Areas protected by system. Each water spray system must protect: (a) All cargo tank...

  15. 46 CFR 154.1110 - Areas protected by system.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false Areas protected by system. 154.1110 Section 154.1110 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY... Firefighting § 154.1110 Areas protected by system. Each water spray system must protect: (a) All cargo tank...

  16. 46 CFR 154.1110 - Areas protected by system.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Areas protected by system. 154.1110 Section 154.1110 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY... Firefighting § 154.1110 Areas protected by system. Each water spray system must protect: (a) All cargo tank...

  17. 46 CFR 154.1110 - Areas protected by system.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Areas protected by system. 154.1110 Section 154.1110 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY... Firefighting § 154.1110 Areas protected by system. Each water spray system must protect: (a) All cargo tank...

  18. Lightning protection of distribution systems

    NASA Astrophysics Data System (ADS)

    Darveniza, M.; Uman, M. A.

    1982-09-01

    Research work on the lightning protection of distribution systems is described. The rationale behind the planning of the first major phase of the work - the field experiments conducted in the Tampa Bay area during August 1978 and July to September 1979 is explained. The aims of the field work were to characterize lightning in the Tampa Bay area, and to identify the lightning parameters associated with the occurrence of line outages and equipment damage on the distribution systems of the participating utilities. The equipment developed for these studies is fully described. The field work provided: general data on lightning - e.g., electric and magnetic fields of cloud and ground flashes; data from automated monitoring of lightning activity; stroke current waveshapes and peak currents measured at distribution arresters; and line outage and equipment damage on 13 kV networks in the Tampa Bay area. Computer aided analyses were required to collate and to process the accumulated data. The computer programs developed for this work are described.

  19. Antidiabetic and Beta Cell-Protection Activities of Purple Corn Anthocyanins

    PubMed Central

    Hong, Su Hee; Heo, Jee-In; Kim, Jeong-Hyeon; Kwon, Sang-Oh; Yeo, Kyung-Mok; Bakowska-Barczak, Anna M.; Kolodziejczyk, Paul; Ryu, Ok-Hyun; Choi, Moon-Ki; Kang, Young-Hee; Lim, Soon Sung; Suh, Hong-Won; Huh, Sung-Oh; Lee, Jae-Yong

    2013-01-01

    Antidiabetic and beta cell-protection activities of purple corn anthocyanins (PCA) were examined in pancreatic beta cell culture and db/db mice. Only PCA among several plant anthocyanins and polyphenols showed insulin secretion activity in culture of HIT-T15 cells. PCA had excellent antihyperglycemic activity (in terms of blood glucose level and OGTT) and HbA1c-decreasing activity when compared with glimepiride, a sulfonylurea in db/db mice. In addition, PCA showed efficient protection activity of pancreatic beta cell from cell death in HIT-T15 cell culture and db/db mice. The result showed that PCA had antidiabetic and beta cell-protection activities in pancreatic beta cell culture and db/db mice. PMID:24244813

  20. Flexible Foam Protection Materials for Portable Life Support System Packaging Study

    NASA Technical Reports Server (NTRS)

    Tang,Henry H.; Dillon, Paul A.; Thomas, Gretchen A.

    2009-01-01

    This paper discusses the phase I effort in evaluating and selecting a light weight impact protection material for the Constellation Space Suit Element (CSSE) Portable Life Support System (PLSS) conceptual packaging study. A light weight material capable of holding and protecting the components inside the PLSS is required to demonstrate the viability of the flexible PLSS packaging concept. The material needs to distribute, dissipate, and absorb the impact energy of the PLSS falling on the lunar surface. It must also be robust to consistently perform over several Extravehicular Activity (EVA) missions in the extreme lunar thermal vacuum environment. This paper documents the performance requirements for selecting a foam protection material, and the methodologies for evaluating some commercial off-the-shelf (COTS) foam material candidates. It also presents the mechanical properties and impact drop tests results of the foam material candidates. The results of this study suggest that a foam based flexible protection system is a viable solution for PLSS packaging. However, additional works are needed to optimize COTS foam or to develop a composite foam system that will meet all the performance requirements for the CSSE PLSS flexible packaging.

  1. UAV Swarm Attack: Protection System Alternatives for Destroyers

    DTIC Science & Technology

    2012-12-01

    Tactical Rocket-Propelled Grenade Airbag Protection System TRL - Technology Readiness Level UAV - Unmanned Aerial Vehicle USN - United States...com- posed of 62 DDGs is $2.014 billion dollars for the 12 year life cycle. J. REACTIVE ARMOR The Tactical Rocket-Propelled Grenade (RPG) Airbag ...Protection System (TRAPS) system involves ‘close-in’ protection using airbags located around a vehicle to minimize the damage from RPGs. This system was

  2. 45 CFR 1386.23 - Periodic reports: Protection and Advocacy System.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... advocacy work and training activities, and the outcomes which it strives to accomplish. (2) Where applicable, the SOP must include a description of how the Protection and Advocacy System operates and how it... for assistance when it is outside the scope of the SOP but they must inform individuals that this is...

  3. 45 CFR 1386.23 - Periodic reports: Protection and Advocacy System.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... advocacy work and training activities, and the outcomes which it strives to accomplish. (2) Where applicable, the SOP must include a description of how the Protection and Advocacy System operates and how it... for assistance when it is outside the scope of the SOP but they must inform individuals that this is...

  4. 45 CFR 1386.23 - Periodic reports: Protection and Advocacy System.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... advocacy work and training activities, and the outcomes which it strives to accomplish. (2) Where applicable, the SOP must include a description of how the Protection and Advocacy System operates and how it... for assistance when it is outside the scope of the SOP but they must inform individuals that this is...

  5. 45 CFR 1386.23 - Periodic reports: Protection and Advocacy System.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... advocacy work and training activities, and the outcomes which it strives to accomplish. (2) Where applicable, the SOP must include a description of how the Protection and Advocacy System operates and how it... for assistance when it is outside the scope of the SOP but they must inform individuals that this is...

  6. 29 CFR 1915.507 - Land-side fire protection systems.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 7 2013-07-01 2013-07-01 false Land-side fire protection systems. 1915.507 Section 1915... Protection in Shipyard Employment § 1915.507 Land-side fire protection systems. (a) Employer responsibilities. The employer must ensure all fixed and portable fire protection systems needed to meet an OSHA...

  7. 29 CFR 1915.507 - Land-side fire protection systems.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 7 2012-07-01 2012-07-01 false Land-side fire protection systems. 1915.507 Section 1915... Protection in Shipyard Employment § 1915.507 Land-side fire protection systems. (a) Employer responsibilities. The employer must ensure all fixed and portable fire protection systems needed to meet an OSHA...

  8. 29 CFR 1915.507 - Land-side fire protection systems.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 7 2011-07-01 2011-07-01 false Land-side fire protection systems. 1915.507 Section 1915... Protection in Shipyard Employment § 1915.507 Land-side fire protection systems. (a) Employer responsibilities. The employer must ensure all fixed and portable fire protection systems needed to meet an OSHA...

  9. 29 CFR 1915.507 - Land-side fire protection systems.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 7 2014-07-01 2014-07-01 false Land-side fire protection systems. 1915.507 Section 1915... Protection in Shipyard Employment § 1915.507 Land-side fire protection systems. (a) Employer responsibilities. The employer must ensure all fixed and portable fire protection systems needed to meet an OSHA...

  10. Reducing Disease Activity in Animal Models of MS by Activation of the Protective Arm of the Renin-Angiotensin System

    DTIC Science & Technology

    2015-10-01

    patients, there is little evidence for a role of ACE2/A( 1 -7)/Mas axis, only a solitary assessment showing decreased ACE2 levels in the CSF of MS...project? Major Goals (Year 1 ): 1 : Measure levels of RAS components in the spinal cord of mice with EAE (animal model of MS) prior to, and at multiple...AWARD NUMBER: W81XWH-14- 1 -0523 TITLE: Reducing Disease Activity in Animal Models of MS by Activation of the Protective Arm of the Renin

  11. Flight Set 360L006 STS-34 field joint protection system, thermal protection system, and systems tunnel components, volume 4

    NASA Technical Reports Server (NTRS)

    Wilkinson, J. P.

    1990-01-01

    The performance of the thermal protection system, field joint protection system, and systems tunnel components of Flight Set 360L006, are documented, as evaluated by postflight hardware inspection. The condition of both motors was similar to previous flights. Sixteen aft edge hits were noted on the ground environment instrumentation thermal protection system. Each hit left a clean substrate, indicating that the damage was caused by nozzle severance debris and/or water impact. No National Space and Transporation System debris criteria for missing thermal protection system were violated. One 5.0 by 1.0 in. unbond was observed on the left hand center field joint K5NA closeout and was elevated to an in-flight anomaly (STS-34-M-4) by the NASA Ice/Debris team. Aft edge damage to the K5NA and an associated black streak indicate that burning debris from the nozzle severance system was the likely cause of the damage. Minor divots caused by debris were seen on previous flights, but this is the first occurrence of a K5NA unbond. Since the unbond occurred after booster separation there is no impact on flight safety and no corrective actions was taken. The right hand center field joint primary heater failed the dielectric withstanding voltage test after joint closeout. The heater was then disabled by opening the circuit breaker, and the redundant heater was used. The redundant heater performed nominally during the launch countdown. A similar condition occurred on Flight 4 when a secondary joint heater failed the dielectric withstanding voltage test.

  12. A continuous operating protection system called COPS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chaperon, G.

    1987-01-01

    The continuous operating protection system called COPS is a diverless solution to achieve the stabilization and protection of subsea pipelines and cables: the system is based on the use of a continuous fabric form work mattress which is spread on the sea bed over the pipeline or cable to be protected by a remotely controlled underwater crawler and simultaneously filled with cement grout. The method has been successfully used in the GULLFAKS field where about 3.6 km of grout mattresses having a cross section of 2 meters by 0.2 meters have been laid. The performances of the system are presentedmore » as well as a trade off comparison with the other stabilization and protection methods currently used: burying, rock dumping or placement of covers.« less

  13. Evaluation of several corrosion protective coating systems on aluminum

    NASA Technical Reports Server (NTRS)

    Higgins, R. H.

    1981-01-01

    A study of several protective coating systems for use on aluminum in seawater/seacoast environments was conducted to review the developments made on protective coatings since early in the Space Shuttle program and to perform comparative studies on these coatings to determine their effectiveness for providing corrosion protection during exposure to seawater/seacoast environments. Panels of 2219-T87 aluminum were coated with 21 different systems and exposed to a 5 percent salt spray for 4000 hr. Application properties, adhesion measurements, heat resistance and corrosion protection were evaluated. For comparative studies, the presently specified Bostik epoxy system used on the SRB structures was included. Results of these tests indicate four systems with outstanding performance and four additional systems with protection almost as good. These systems are based on a chromated pretreatment, a chromate epoxy primer, and a polyurethane topcoat. Consideration for one of these systems should be included for those applications where superior corrosion protection for aluminum surfaces is required.

  14. Incipient fault detection and power system protection for spaceborne systems

    NASA Technical Reports Server (NTRS)

    Russell, B. Don; Hackler, Irene M.

    1987-01-01

    A program was initiated to study the feasibility of using advanced terrestrial power system protection techniques for spacecraft power systems. It was designed to enhance and automate spacecraft power distribution systems in the areas of safety, reliability and maintenance. The proposed power management/distribution system is described as well as security assessment and control, incipient and low current fault detection, and the proposed spaceborne protection system. It is noted that the intelligent remote power controller permits the implementation of digital relaying algorithms with both adaptive and programmable characteristics.

  15. The information protection level assessment system implementation

    NASA Astrophysics Data System (ADS)

    Trapeznikov, E. V.

    2018-04-01

    Currently, the threat of various attacks increases significantly as automated systems become more widespread. On the basis of the conducted analysis the information protection level assessment system establishing objective was identified. The paper presents the information protection level assessment software implementation in the information system by applying the programming language C #. In conclusions the software features are identified and experimental results are represented.

  16. Protection of the wilderness and aesthetic values of Antarctica: Geographical Information Systems (GIS) as a tool

    Treesearch

    Rupert Summerson; Tina Tin

    2011-01-01

    Antarctica is designated by the Antarctic Treaty System as a "natural reserve devoted to peace and science" (http://www.ats.aq/index_e.htm). Multiple, and sometimes conflicting, values are protected. In a place where wilderness protection and certain forms of human activity are both prized, a discussion of the protection of the Antarctic wilderness...

  17. Operational test report -- Project W-320 cathodic protection systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bowman, T.J.

    1998-06-16

    Washington Administrative Code (WAC) 173-303-640 specifies that corrosion protection must be designed into tank systems that treat or store dangerous wastes. Project W-320, Waste Retrieval Sluicing System (WRSS), utilizes underground encased waste transfer piping between tanks 241-C-106 and 241-AY-102. Corrosion protection is afforded to the encasements of the WRSS waste transfer piping through the application of earthen ionic currents onto the surface of the piping encasements. Cathodic protection is used in conjunction with the protective coatings that are applied upon the WRSS encasement piping. WRSS installed two new two rectifier systems (46 and 47) and modified one rectifier system (31).more » WAC 173-303-640 specifies that the proper operation of cathodic protection systems must be confirmed within six months after initial installation. The WRSS cathodic protection systems were energized to begin continuous operation on 5/5/98. Sixteen days after the initial steady-state start-up of the WRSS rectifier systems, the operational testing was accomplished with procedure OTP-320-006 Rev/Mod A-0. This operational test report documents the OTP-320-006 results and documents the results of configuration testing of integrated piping and rectifier systems associated with the W-320 cathodic protection systems.« less

  18. 14 CFR 29.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Fuel System § 29.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Fuel system lightning protection. 29.954...

  19. 14 CFR 29.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Fuel System § 29.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Fuel system lightning protection. 29.954...

  20. 14 CFR 27.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Powerplant Fuel System § 27.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Fuel system lightning protection. 27.954...

  1. 14 CFR 25.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Powerplant Fuel System § 25.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Fuel system lightning protection. 25.954...

  2. 14 CFR 29.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Fuel System § 29.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Fuel system lightning protection. 29.954...

  3. 14 CFR 27.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Powerplant Fuel System § 27.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fuel system lightning protection. 27.954...

  4. 14 CFR 29.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Fuel System § 29.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Fuel system lightning protection. 29.954...

  5. 14 CFR 27.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Powerplant Fuel System § 27.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Fuel system lightning protection. 27.954...

  6. 14 CFR 25.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Powerplant Fuel System § 25.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fuel system lightning protection. 25.954...

  7. 14 CFR 25.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Powerplant Fuel System § 25.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Fuel system lightning protection. 25.954...

  8. 14 CFR 25.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Powerplant Fuel System § 25.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Fuel system lightning protection. 25.954...

  9. 14 CFR 27.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Powerplant Fuel System § 27.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Fuel system lightning protection. 27.954...

  10. 14 CFR 29.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Fuel System § 29.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fuel system lightning protection. 29.954...

  11. 14 CFR 27.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Powerplant Fuel System § 27.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Fuel system lightning protection. 27.954...

  12. 14 CFR 25.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Powerplant Fuel System § 25.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Fuel system lightning protection. 25.954...

  13. 14 CFR 23.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Fuel system lightning protection. 23.954... Fuel System § 23.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor within the system by— (a) Direct lightning strikes to areas having a...

  14. 14 CFR 23.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Fuel system lightning protection. 23.954... Fuel System § 23.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor within the system by— (a) Direct lightning strikes to areas having a...

  15. 14 CFR 23.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fuel system lightning protection. 23.954... Fuel System § 23.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor within the system by— (a) Direct lightning strikes to areas having a...

  16. 14 CFR 23.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Fuel system lightning protection. 23.954... Fuel System § 23.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor within the system by— (a) Direct lightning strikes to areas having a...

  17. 14 CFR 23.954 - Fuel system lightning protection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Fuel system lightning protection. 23.954... Fuel System § 23.954 Fuel system lightning protection. The fuel system must be designed and arranged to prevent the ignition of fuel vapor within the system by— (a) Direct lightning strikes to areas having a...

  18. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity

    PubMed Central

    Panossian, Alexander; Wikman, Georg

    2010-01-01

    Adaptogens were initially defined as substances that enhance the “state of non-specific resistance” in stress, a physiological condition that is linked with various disorders of the neuroendocrine-immune system. Studies on animals and isolated neuronal cells have revealed that adaptogens exhibit neuroprotective, anti-fatigue, antidepressive, anxiolytic, nootropic and CNS stimulating activity. In addition, a number of clinical trials demonstrate that adaptogens exert an anti-fatigue effect that increases mental work capacity against a background of stress and fatigue, particularly in tolerance to mental exhaustion and enhanced attention. Indeed, recent pharmacological studies of a number of adaptogens have provided a rationale for these effects also at the molecular level. It was discovered that the stress—protective activity of adaptogens was associated with regulation of homeostasis via several mechanisms of action, which was linked with the hypothalamic-pituitary-adrenal axis and the regulation of key mediators of stress response, such as molecular chaperons (e.g., HSP70), stress-activated c-Jun N-terminal protein kinase 1 (JNK1), Forkhead box O (FOXO) transcription factor DAF-16, cortisol and nitric oxide. PMID:27713248

  19. 29 CFR 1915.507 - Land-side fire protection systems.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... specific recommendations in NFPA 14-2003 Standard for the Installation of Standpipe and Hose Systems... 29 Labor 7 2010-07-01 2010-07-01 false Land-side fire protection systems. 1915.507 Section 1915... Protection in Shipyard Employment § 1915.507 Land-side fire protection systems. (a) Employer responsibilities...

  20. System and method for quench protection of a superconductor

    DOEpatents

    Huang, Xianrui; Sivasubramaniam, Kiruba Haran; Bray, James William; Ryan, David Thomas

    2008-03-11

    A system and method for protecting a superconductor from a quench condition. A quench protection system is provided to protect the superconductor from damage due to a quench condition. The quench protection system comprises a voltage detector operable to detect voltage across the superconductor. The system also comprises a frequency filter coupled to the voltage detector. The frequency filter is operable to couple voltage signals to a control circuit that are representative of a rise in superconductor voltage caused by a quench condition and to block voltage signals that are not. The system is operable to detect whether a quench condition exists in the superconductor based on the voltage signal received via the frequency filter and to initiate a protective action in response.

  1. Graphdiyne Nanoparticles with High Free Radical Scavenging Activity for Radiation Protection.

    PubMed

    Xie, Jiani; Wang, Ning; Dong, Xinghua; Wang, Chengyan; Du, Zhen; Mei, Linqiang; Yong, Yuan; Huang, Changshui; Li, Yuliang; Gu, Zhanjun; Zhao, Yuliang

    2018-03-06

    Numerous carbon networks materials comprised of benzene moieties, such as graphene and fullerene, have held great fascination for radioprotection because of their acknowledged good biocompatibility and strong free radical scavenging activity derived from their delocalized π-conjugated structure. Recently, graphdiyne, a new emerging carbon network material consisting of a unique chemical structure of benzene and acetylenic moieties, has gradually attracted attention in many research fields. Encouraged by its unique structure with strong conjugated π-system and highly reactive diacetylenic linkages, graphdiyne might have free radical activity and can thus be used as a radioprotector, which has not been investigated so far. Herein, for the first time, we synthesized bovine serum albumin (BSA)-modified graphdiyne nanoparticles (graphdiyne-BSA NPs) to evaluate their free radical scavenging ability and investigate their application for radioprotection both in cell and animal models. In vitro studies indicated that the graphdiyne-BSA NPs could effectively eliminate the free-radicals, decrease radiation-induced DNA damage in cells, and improve the viability of cells under ionizing radiation. In vivo experiments showed that the graphdiyne-BSA NPs could protect the bone marrow DNA of mice from radiation-induced damage and make the superoxide dismutase (SOD) and malondialdehyde (MDA) (two kinds of vital indicators of radiation-induced injury) recover back to normal levels. Furthermore, the good biocompatibility and negligible systemically toxicity responses of the graphdiyne-BSA NPs to mice were verified. All these results manifest the good biosafety and radioprotection activity of graphdiyne-BSA NPs to normal tissues. Therefore, our studies not only provide a new radiation protection platform based on graphdiyne for protecting normal tissues from radiation-caused injury but also provide a promising direction for the application of graphdiyne in the biomedicine field.

  2. MER surface fault protection system

    NASA Technical Reports Server (NTRS)

    Neilson, Tracy

    2005-01-01

    The Mars Exploration Rovers surface fault protection design was influenced by the fact that the solar-powered rovers must recharge their batteries during the day to survive the night. the rovers needed to autonomously maintain thermal stability, initiate safe and reliable communication with orbiting assets or directly to Earth, while maintaining energy balance. This paper will describe the system fault protection design for the surface phase of the mission.

  3. Future Interoperability of Camp Protection Systems (FICAPS)

    NASA Astrophysics Data System (ADS)

    Caron, Sylvie; Gündisch, Rainer; Marchand, Alain; Stahl, Karl-Hermann

    2013-05-01

    The FICAPS Project has been established as a Project of the European Defence Agency based on an initiative of Germany and France. Goal of this Project was to derive Guidelines, which by a proper implementation in future developments improve Camp Protection Systems (CPS) by enabling and improving interoperability between Camp Protection Systems and its Equipments of different Nations involved in multinational missions. These Guidelines shall allow for: • Real-time information exchange between equipments and systems of different suppliers and nations (even via SatCom), • Quick and easy replacement of equipments (even of different Nations) at run-time in the field by means of plug and play capability, thus lowering the operational and logistic costs and making the system highly available, • Enhancement of system capabilities (open and modular systems) by adding new equipment with new capabilities (just plug-in, automatic adjustment of the HMI Human Machine Interface) without costly and time consuming validation and test on system level (validation and test can be done on Equipment level), Four scenarios have been identified to summarize the interoperability requirements from an operational viewpoint. To prove the definitions given in the Guideline Document, a French and a German Demonstration System, based on existing national assets, were realized. Demonstrations, showing the capabilities given by the defined interoperability requirements with respect to the operational scenarios, were performed. Demonstrations included remote control of a CPS by another CPS, remote sensor control (Electro-Optic/InfraRed EO/IR) and remote effector control. This capability can be applied to extend the protection area or to protect distant infrastructural assets Demonstrations have been performed. The required interoperability functionality was shown successfully. Even if the focus of the FICAPS project was on camp protection, the solution found is also appropriate for other

  4. Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes.

    PubMed

    Rubiolo, Juan Andrés; Mithieux, Gilles; Vega, Félix Victor

    2008-09-04

    Oxidative stress is recognized as an important factor in the development of liver pathologies. The reactive oxygen species endogenously generated or as a consequence of xenobiotic metabolism are eliminated by enzymatic and nonenzymatic cellular systems. Besides endogen defences, the antioxidant consumption in the diet has an important role in the protection against the development of diseases product of oxidative damage. Resveratrol is a naturally occurring compound which is part of the human diet. This molecule has been shown to have many biological properties, including antioxidant activity. We decided to test if resveratrol could protect primary hepatocytes in culture from oxidative stress damage and if so, to determine if this compound affects the cellular detoxifying systems and their regulation through the Nrf2 transcription factor that regulates the expression of antioxidant and phase II detoxifying enzymes. Cell death by necrosis was detected by measuring the activity of lactate dehydrogenase liberated to the medium. The activities of antioxidant and phase II enzymes were measured using previously described methods. Activation of the Nrf2 transcription factor was studied by confocal microscopy and the Nrf2 and its coding mRNA levels were determined by western blot and quantitative PCR respectively. Resveratrol pre-treatment effectively protected hepatocytes in culture exposed to oxidative stress, increasing the activities of catalase, superoxide dismutase, glutathione peroxidase, NADPH quinone oxidoreductase and glutathione-S-transferase. Resveratrol increases the level of Nrf2 and induces its translocation to the nucleus. Also, it increases the concentration of the coding mRNA for Nrf2. In this work we show that resveratrol could be a useful drug for the protection of liver cells from oxidative stress induced damage.

  5. Self-diagnostic thermal protection systems for future spacecraft

    NASA Astrophysics Data System (ADS)

    Hanlon, Alaina B.

    The thermal protection system (TPS) represents the greatest risk factor after propulsion for any transatmospheric mission (Dr. Charles Smith, NASA ARC). Any damage to the TPS leaves the space vehicle vulnerable and could result in the loss of human life as happened in the Columbia accident. Aboard the current Space Shuttle Orbiters no system exists to notify the astronauts or ground control if the thermal protection system has been damaged. Through this research, a proof-of-concept monitoring system was developed. The system has two specific applications for thermal protection systems: (1) Improving models used to predict thermal and mechanical response of TPS materials, and (2) Self-diagnosing damage within regions of the TPS and communicating the damage to the appropriate personnel over a potentially unstable network. Mechanical damage is among the most important things to protect the TPS against. Methods to detect the primary types of mechanical damage suffered by thermal protection systems have been developed. Lightweight, low-power sensors were developed to detect any cracks in small regions of a TPS. Implementation of a network of these sensors within 10's to 1000's of regions will eventually provide high spatial resolution of damage detection; allowing for detection of holes in the TPS. Also important in thermal protection material development is to know the ablation rates and time/temperature response of the materials. A new type of sensor has been developed to monitor temperature at different depths within thermal protection materials. The signals being transmitted through the sensors can be multiplexed to allow for mechanical damage and temperature to be monitored using the same sensor.

  6. Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis.

    PubMed

    Morsali, Damineh; Bechtold, David; Lee, Woojin; Chauhdry, Summen; Palchaudhuri, Upayan; Hassoon, Paula; Snell, Daniel M; Malpass, Katy; Piers, Thomas; Pocock, Jennifer; Roach, Arthur; Smith, Kenneth J

    2013-04-01

    Axonal degeneration is a major cause of permanent disability in the inflammatory demyelinating disease multiple sclerosis, but no therapies are known to be effective in axonal protection. Sodium channel blocking agents can provide effective protection of axons in the white matter in experimental models of multiple sclerosis, but the mechanism of action (directly on axons or indirectly via immune modulation) remains uncertain. Here we have examined the efficacy of two sodium channel blocking agents to protect white matter axons in two forms of experimental autoimmune encephalomyelitis, a common model of multiple sclerosis. Safinamide is currently in phase III development for use in Parkinson's disease based on its inhibition of monoamine oxidase B, but the drug is also a potent state-dependent inhibitor of sodium channels. Safinamide provided significant protection against neurological deficit and axonal degeneration in experimental autoimmune encephalomyelitis, even when administration was delayed until after the onset of neurological deficit. Protection of axons was associated with a significant reduction in the activation of microglia/macrophages within the central nervous system. To clarify which property of safinamide was likely to be involved in the suppression of the innate immune cells, the action of safinamide on microglia/macrophages was compared with that of the classical sodium channel blocking agent, flecainide, which has no recognized monoamine oxidase B activity, and which has previously been shown to protect the white matter in experimental autoimmune encephalomyelitis. Flecainide was also potent in suppressing microglial activation in experimental autoimmune encephalomyelitis. To distinguish whether the suppression of microglia was an indirect consequence of the reduction in axonal damage, or possibly instrumental in the axonal protection, the action of safinamide was examined in separate experiments in vitro. In cultured primary rat microglial

  7. Thermal Protection System with Staggered Joints

    NASA Technical Reports Server (NTRS)

    Simon, Xavier D. (Inventor); Robinson, Michael J. (Inventor); Andrews, Thomas L. (Inventor)

    2014-01-01

    The thermal protection system disclosed herein is suitable for use with a spacecraft such as a reentry module or vehicle, where the spacecraft has a convex surface to be protected. An embodiment of the thermal protection system includes a plurality of heat resistant panels, each having an outer surface configured for exposure to atmosphere, an inner surface opposite the outer surface and configured for attachment to the convex surface of the spacecraft, and a joint edge defined between the outer surface and the inner surface. The joint edges of adjacent ones of the heat resistant panels are configured to mate with each other to form staggered joints that run between the peak of the convex surface and the base section of the convex surface.

  8. [Anti-Candida activity of aroma candy and its protective activity against murine oral candidiasis].

    PubMed

    Hayama, Kazumi; Takahashi, Miki; Suzuki, Motofumi; Ezawa, Kunio; Yamazaki, Masatoshi; Matsukawa, Taiji; Kishi, Akinobu; Sato, Nobuya; Abe, Shigeru

    2015-01-01

    A daily eatable candy that has possible protective activity against oral candidiasis was experimentally produced. The candy was made from reduced-maltose as main constituent and from several natural products, such as oligonol (depolymerized polyphenols derived from lychee), cinnamon (cassia), citral, and capric acid, which are known to have anti-Candida activity in vitro and in vivo. The candy effectively inhibited the mycelial growth of C. albicans, even when it was diluted 1,000 times with culture media. We assessed the protective activity of the candy against murine candidiasis. When 50μl of candy dissolved and diluted 4 times with water was administered 3 times into the oral cavity of Candida infected mice, the score of lesions on the Candida-infected tongues improved on day 2. These findings suggest that this candy has potential as food that provides protective activity against oral candidiasis.

  9. Novel Directional Protection Scheme for the FREEDM Smart Grid System

    NASA Astrophysics Data System (ADS)

    Sharma, Nitish

    This research primarily deals with the design and validation of the protection system for a large scale meshed distribution system. The large scale system simulation (LSSS) is a system level PSCAD model which is used to validate component models for different time-scale platforms, to provide a virtual testing platform for the Future Renewable Electric Energy Delivery and Management (FREEDM) system. It is also used to validate the cases of power system protection, renewable energy integration and storage, and load profiles. The protection of the FREEDM system against any abnormal condition is one of the important tasks. The addition of distributed generation and power electronic based solid state transformer adds to the complexity of the protection. The FREEDM loop system has a fault current limiter and in addition, the Solid State Transformer (SST) limits the fault current at 2.0 per unit. Former students at ASU have developed the protection scheme using fiber-optic cable. However, during the NSF-FREEDM site visit, the National Science Foundation (NSF) team regarded the system incompatible for the long distances. Hence, a new protection scheme with a wireless scheme is presented in this thesis. The use of wireless communication is extended to protect the large scale meshed distributed generation from any fault. The trip signal generated by the pilot protection system is used to trigger the FID (fault isolation device) which is an electronic circuit breaker operation (switched off/opening the FIDs). The trip signal must be received and accepted by the SST, and it must block the SST operation immediately. A comprehensive protection system for the large scale meshed distribution system has been developed in PSCAD with the ability to quickly detect the faults. The validation of the protection system is performed by building a hardware model using commercial relays at the ASU power laboratory.

  10. Evolution of the Radiological Protection System and its Implementation.

    PubMed

    Lazo, Edward

    2016-02-01

    The International System of Radiological Protection, developed, maintained, and elaborated by the International Commission on Radiological Protection (ICRP) has, for the past 50 y, provided a robust framework for developing radiological protection policy, regulation, and application. It has, however, been evolving as a result of experience with its implementation, modernization of social awareness of a shrinking world where the Internet links everyone instantly, and increasing public interest in safety-related decisions. These currents have gently pushed the ICRP in recent years to focus more sharply on particular aspects of its system: optimization, prevailing circumstances, the use of effective dose and aspects of an individual's risk, and consideration of the independent implementation of the international system's elements. This paper will present these issues and their relevance to the ICRP system of protection and its evolution. The broader framework of radiological protection (e.g., science, philosophy, policy, regulation, implementation), of which the ICRP is an important element, will provide a global, equally evolving context for this characterization of the changing ICRP system of radiological protection.

  11. Sun Protection Preferences and Behaviors among Young Adult Males during Maximum Ultraviolet Radiation Exposure Activities

    PubMed Central

    Wickenheiser, Marilyn; Baker, Mary Kate; Gaber, Rikki; Blatt, Hanz; Robinson, June K.

    2013-01-01

    This study explores sun protection attitudes, preferences, and behaviors among young adult males participating in an open-field activity with extreme ultraviolet radiation exposure. Male drum corps members (n = 137) responded to survey questions regarding their behavior and willingness to engage in sun protection and barriers to sunscreen usage. A subset of members (n = 31) participated in cognitive interviews exploring various sunscreen products and intervention techniques. Participants were knowledgeable about health risks and protection benefits regarding sun exposure. Generally, males had positive attitudes and normative beliefs about using sunscreen. A barrier to sunscreen re-application was lack of adequate time to reapply sunscreen during the open field activity. Males preferred a towelette application method, but were unfamiliar with its efficacy and proper use. Thus, they were more likely to use the more familiar sunscreen spray. To increase sun protection behaviors and lower skin cancer risk for males participating in open-field activities, breaks must be allotted every 2 h and have sufficient time to allow sunscreen application. Future development and research into delivery systems that rapidly and evenly apply sunscreen may help lower exposure in this population. PMID:23912201

  12. 49 CFR 179.20 - Service equipment; protection systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Service equipment; protection systems. 179.20 Section 179.20 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND... CARS General Design Requirements § 179.20 Service equipment; protection systems. If an applicable tank...

  13. A slotted cathodic protection system for bridge decks.

    DOT National Transportation Integrated Search

    1985-01-01

    A non-overlay, slotted cathodic protection system was installed two years ago on a concrete bridge deck in Virginia. The design, installation, and operation of this system are fairly straightforward. A protective current density of 1.6 mA/ft (17 mA...

  14. Natural Killer T Cell Activation Protects Mice Against Experimental Autoimmune Encephalomyelitis

    PubMed Central

    Singh, Avneesh K.; Wilson, Michael T.; Hong, Seokmann; Olivares-Villagómez, Danyvid; Du, Caigan; Stanic, Aleksandar K.; Joyce, Sebastian; Sriram, Subramaniam; Koezuka, Yasuhiko; Van Kaer, Luc

    2001-01-01

    Experimental autoimmune encephalomyelitis (EAE) serves as a prototypic model for T cell–mediated autoimmunity. Vα14 natural killer T (NKT) cells are a subset of T lymphocytes that recognize glycolipid antigens presented by the nonpolymorphic major histocompatibility complex (MHC) class I–like protein CD1d. Here, we show that activation of Vα14 NKT cells by the glycosphingolipid α-galactosylceramide (α-GalCer) protects susceptible mice against EAE. β-GalCer, which binds CD1d but is not recognized by NKT cells, failed to protect mice against EAE. Furthermore, α-GalCer was unable to protect CD1d knockout (KO) mice against EAE, indicating the requirement for an intact CD1d antigen presentation pathway. Protection of disease conferred by α-GalCer correlated with its ability to suppress myelin antigen-specific Th1 responses and/or to promote myelin antigen-specific Th2 cell responses. α-GalCer was unable to protect IL-4 KO and IL-10 KO mice against EAE, indicating a critical role for both of these cytokines. Because recognition of α-GalCer by NKT cells is phylogenetically conserved, our findings have identified NKT cells as novel target cells for treatment of inflammatory diseases of the central nervous system. PMID:11748281

  15. Criminal law repercussions on the Civil Protection System

    NASA Astrophysics Data System (ADS)

    Altamura, M.; Musso, L.

    2009-09-01

    The legal systems of our Countries provide the citizenship with a high level of protection. Personal safety and the protection of property are guaranteed by the State through organized structures among which we can include the Civil Protection. The progress of science and technology has greatly improved monitoring tools, currently used by the Civil Protection, which allow, to a certain extent, to predict and prevent risk and natural hazards. The assertion of an individual right, which in some cases has reached a constitutional rank, to benefit from Civil Protection services and the widespread perception throughout the citizenship of the competence of the system to prevent disasters, often causes people to take legal action against Civil Protection authorities should they fail in their duties to protect. However, the attempt of having both recognized an economic compensation for the suffered loss and the punishment of those whom misled, frequently undergoes criminal law. This process could have results that may jeopardize the effectiveness of Civil Protection service without meeting citizens’ demands. A dual effort is thus necessary in order to solve such a problem. On the one hand, an interdisciplinary knowledge needs to pervade criminal law in an attempt to relieve its self-referentiality and pretended supremacy. On the other hand an alternative, and more agile, system -such as civil or administrative law- has to be identified in order to respond to the legitimate requests for protection in the case of a faulty behaviour of the authorities.

  16. Space activities and radiation protection of crew members

    NASA Astrophysics Data System (ADS)

    Straube, Ulrich; Berger, Thomas; Reitz, Guenther; Facius, Rainer; Reiter, Thomas; Kehl, Marcel; Damann, M. D. Volker; Tognini, Michel

    Personnel working as crew in space-based activities e.g. professional astronauts and cosmo-nauts but also -to a certain extend-space flight participants ("space tourists"), demand health and safety considerations that have to include radiation protection measures. The radiation environment that a crew is exposed to during a space flight, differs significantly to that found on earth including commercial aviation, mainly due to the presence of heavy charged particles with great potential for biological damage. The exposure exceeds those routinely received by terrestrial radiation workers. A sequence of activities has to be conducted targeting to mitigate adverse effects of space radiation. Considerable information is available and applied through the joint efforts of the Space Agencies that are involved in the operations of the International Space Station, ISS. This presentation will give an introduction to the current measures for ra-diation monitoring and protection of astronauts of the European Space Agency (ESA). It will include information: on the radiation protection guidelines that shall ensure the proper imple-mentation and execution of radiation protection measures, the operational hardware used for radiation monitoring and personal dosimetry on ISS, as well as information about operational procedures that are applied.

  17. The response of antioxidant systems in Nostoc sphaeroides against UV-B radiation and the protective effects of exogenous antioxidants

    NASA Astrophysics Data System (ADS)

    Wang, Gaohong; Hu, Chunxiang; Li, Dunhai; Zhang, Delu; Li, Xiaoyan; Chen, Kun; Liu, Yongding

    UV radiation is one of many harmful factors found in space that are detrimental to organisms on earth in space exploration. In the present work, we examined the role of antioxidant system in Nostoc sphaeroides Kütz (Cyanobacterium) and the effects of exogenously applied antioxidant molecules on its photosynthetic rate under UV-B radiation. It was found that UV-B radiation promoted the activity of antioxidant system to protect photosystem II (PSII) and exogenously applied antioxidant: sodium nitroprusside (SNP) and N-acetylcysteine (NAC) had an obvious protection on PSII activity under UV-B radiation. The activity of superoxide dismutase (SOD, EC 1.15.1.1), catalase (CAT, EC 1.11.1.6), peroxidase (POD, EC 1.11.1.7) and content of MDA (malondialdehyde) and ASC (ascorbate) were improved by 0.5 mM and 1 mM SNP, but 0.1 mM SNP decreased the activity of antioxidant system. Addition of exogenous NAC decreased the activity of SOD, POD, CAT and the content MDA and ASC. In contrast, exogenously applied NAC increased GSH content. The results suggest that exogenous SNP and NAC may protect algae by different mechanisms: SNP may play double roles as both sources of reactive free radicals as well as ROS scavengers in mediating the protective role of PSII on algae under UV-B radiation. On the other hand, NAC functions as an antioxidant or precursor of glutathione, which could protect PSII directly from UV-B radiation.

  18. Groundwater protection of minimal water supply systems integrating simple hydrogeological information

    NASA Astrophysics Data System (ADS)

    Rodrigo-Ilarri, Javier; Rodrigo-Clavero, María Elena

    2016-04-01

    According to the current EU environmental legislation, groundwater protection is one of the key issues to be addressed when new industrial activities have to be authorised. This work shows a simple methodology that could be used by local and environmental authorities in order to analyse the potential risk caused by an industrial spill on a natural environment. The methodology leads to the determination of the protection area around an extraction well system using the information given by: i) a set of local piezometers, ii) the chemical nature of the industrial spill and iii) the hydrogeological parameters of the local aquifer. The exact location of the contaminant source is not needed for the analysis. The flow equation is afterwards solved using a finite-difference approximation scheme under stationary conditions. Finally, the capture zones for different times are computed by a simple upstream advective transport model. Results on the determination of the perimeter protection area definition of a water supply system in the municipality of L'Alcora (Castellón) in Spain are shown.

  19. Displacements of Metallic Thermal Protection System Panels During Reentry

    NASA Technical Reports Server (NTRS)

    Daryabeigi, Kamran; Blosser, Max L.; Wurster, Kathryn E.

    2006-01-01

    Bowing of metallic thermal protection systems for reentry of a previously proposed single-stage-to-orbit reusable launch vehicle was studied. The outer layer of current metallic thermal protection system concepts typically consists of a honeycomb panel made of a high temperature nickel alloy. During portions of reentry when the thermal protection system is exposed to rapidly varying heating rates, a significant temperature gradient develops across the honeycomb panel thickness, resulting in bowing of the honeycomb panel. The deformations of the honeycomb panel increase the roughness of the outer mold line of the vehicle, which could possibly result in premature boundary layer transition, resulting in significantly higher downstream heating rates. The aerothermal loads and parameters for three locations on the centerline of the windward side of this vehicle were calculated using an engineering code. The transient temperature distributions through a metallic thermal protection system were obtained using 1-D finite volume thermal analysis, and the resulting displacements of the thermal protection system were calculated. The maximum deflection of the thermal protection system throughout the reentry trajectory was 6.4 mm. The maximum ratio of deflection to boundary layer thickness was 0.032. Based on previously developed distributed roughness correlations, it was concluded that these defections will not result in tripping the hypersonic boundary layer.

  20. Actively Controlled Magnetic Vibration-Isolation System

    NASA Technical Reports Server (NTRS)

    Grodsinky, Carlos M.; Logsdon, Kirk A.; Wbomski, Joseph F.; Brown, Gerald V.

    1993-01-01

    Prototype magnetic suspension system with active control isolates object from vibrations in all six degrees of freedom at frequencies as low as 0.01 Hz. Designed specifically to protect instruments aboard spacecraft by suppressing vibrations to microgravity levels; basic control approach used for such terrestrial uses as suppression of shocks and other vibrations in trucks and railroad cars.

  1. Hybrid Plasma Reactor/Filter for Transportable Collective Protection Systems

    DTIC Science & Technology

    2011-03-01

    protection. The key premise of the hybrid system is to couple a nonthermal plasma (NTP) reactor with reactive adsorption to provide a broader envelope of...conventional methods for collective protection. The key premise of the hybrid system is to couple a nonthermal plasma (NTP) reactor with reactive adsorption to...protection. The key premise of the hybrid system is to couple a nonthermal plasma (NTP) reactor with reactive adsorption to provide a broader

  2. Outer skin protection of columbium Thermal Protection System (TPS) panels

    NASA Technical Reports Server (NTRS)

    Culp, J. D.

    1973-01-01

    A coated columbium alloy material system 0.04 centimeter thick was developed which provides for increased reliability to the load bearing character of the system in the event of physical damage to and loss of the exterior protective coating. The increased reliability to the load bearing columbium alloy (FS-85) was achieved by interposing an oxidation resistant columbium alloy (B-1) between the FS-85 alloy and a fused slurry silicide coating. The B-1 alloy was applied as a cladding to the FS-85 and the composite was fused slurry silicide coated. Results of material evaluation testing included cyclic oxidation testing of specimens with intentional coating defects, tensile testing of several material combinations exposed to reentry profile conditions, and emittance testing after cycling of up to 100 simulated reentries. The clad material, which was shown to provide greater reliability than unclad materials, holds significant promise for use in the thermal protection system of hypersonic reentry vehicles.

  3. 10 CFR 73.50 - Requirements for physical protection of licensed activities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Requirements for physical protection of licensed activities. 73.50 Section 73.50 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF... suspicious activity or to the breaching of any physical barrier. (4) An isolation zone shall be maintained...

  4. Systems analysis of protective immune responses to RTS,S malaria vaccination in humans

    PubMed Central

    Kazmin, Dmitri; Nakaya, Helder I.; Lee, Eva K.; Johnson, Matthew J.; van der Most, Robbert; van den Berg, Robert A.; Ballou, W. Ripley; Jongert, Erik; Wille-Reece, Ulrike; Ockenhouse, Christian; Aderem, Alan; Zak, Daniel E.; Sadoff, Jerald; Hendriks, Jenny; Wrammert, Jens; Ahmed, Rafi; Pulendran, Bali

    2017-01-01

    RTS,S is an advanced malaria vaccine candidate and confers significant protection against Plasmodium falciparum infection in humans. Little is known about the molecular mechanisms driving vaccine immunity. Here, we applied a systems biology approach to study immune responses in subjects receiving three consecutive immunizations with RTS,S (RRR), or in those receiving two immunizations of RTS,S/AS01 following a primary immunization with adenovirus 35 (Ad35) (ARR) vector expressing circumsporozoite protein. Subsequent controlled human malaria challenge (CHMI) of the vaccinees with Plasmodium-infected mosquitoes, 3 wk after the final immunization, resulted in ∼50% protection in both groups of vaccinees. Circumsporozoite protein (CSP)-specific antibody titers, prechallenge, were associated with protection in the RRR group. In contrast, ARR-induced lower antibody responses, and protection was associated with polyfunctional CD4+ T-cell responses 2 wk after priming with Ad35. Molecular signatures of B and plasma cells detected in PBMCs were highly correlated with antibody titers prechallenge and protection in the RRR cohort. In contrast, early signatures of innate immunity and dendritic cell activation were highly associated with protection in the ARR cohort. For both vaccine regimens, natural killer (NK) cell signatures negatively correlated with and predicted protection. These results suggest that protective immunity against P. falciparum can be achieved via multiple mechanisms and highlight the utility of systems approaches in defining molecular correlates of protection to vaccination. PMID:28193898

  5. Illustration of distributed generation effects on protection system coordination

    NASA Astrophysics Data System (ADS)

    Alawami, Hussain Adnan

    Environmental concerns, market forces, and emergence of new technologies have recently resulted in restructuring electric utility from vertically integrated networks to competitive deregulated entities. Distributed generation (DG) is playing a major role in such deregulated markets. When they are installed in small amounts and small sizes, their impacts on the system may be negligible. When their penetration levels increase as well as their sizes, however, they may start affecting the system performance from more than one aspect. Power system protection needs to be re-assessed after the emergence of DG. This thesis attempts to illustrate the impact of DG on the power system protection coordination. It will study the operation of the impedance relays, fuses, reclosers and overcurrent relays when a DG is added to the distribution network. Different DG sizes, distances from the network and locations within the distribution system will be considered. Power system protection coordination is very sensitive to the DG size where it is not for the DG distance. DG location has direct impact on the operation of the protective devices especially when it is inserted in the middle point of the distribution system. Key Words, Distributed Generation, Impedance relay, fuses, reclosers, overcurrent relays, power system protection coordination.

  6. 14 CFR 25.869 - Fire protection: systems.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... protection: systems. (a) Electrical system components: (1) Components of the electrical system must meet the... the discharge side of the pump that might contain flammable vapors or fluids must meet the...

  7. 14 CFR 29.1359 - Electrical system fire and smoke protection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Electrical system fire and smoke protection... Equipment § 29.1359 Electrical system fire and smoke protection. (a) Components of the electrical system must meet the applicable fire and smoke protection provisions of §§ 29.831 and 29.863. (b) Electrical...

  8. 14 CFR 29.1359 - Electrical system fire and smoke protection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Electrical system fire and smoke protection... Equipment § 29.1359 Electrical system fire and smoke protection. (a) Components of the electrical system must meet the applicable fire and smoke protection provisions of §§ 29.831 and 29.863. (b) Electrical...

  9. 14 CFR 29.1359 - Electrical system fire and smoke protection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Electrical system fire and smoke protection... Equipment § 29.1359 Electrical system fire and smoke protection. (a) Components of the electrical system must meet the applicable fire and smoke protection provisions of §§ 29.831 and 29.863. (b) Electrical...

  10. 14 CFR 29.1359 - Electrical system fire and smoke protection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Electrical system fire and smoke protection... Equipment § 29.1359 Electrical system fire and smoke protection. (a) Components of the electrical system must meet the applicable fire and smoke protection provisions of §§ 29.831 and 29.863. (b) Electrical...

  11. Systems and methods for photovoltaic string protection

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Krein, Philip T.; Kim, Katherine A.; Pilawa-Podgurski, Robert C. N.

    A system and method includes a circuit for protecting a photovoltaic string. A bypass switch connects in parallel to the photovoltaic string and a hot spot protection switch connects in series with the photovoltaic string. A first control signal controls opening and closing of the bypass switch and a second control signal controls opening and closing of the hot spot protection switch. Upon detection of a hot spot condition the first control signal closes the bypass switch and after the bypass switch is closed the second control signal opens the hot spot protection switch.

  12. Evolution of thiol protective systems in prokaryotes

    NASA Technical Reports Server (NTRS)

    Fahey, R. C.; Newton, G. L.

    1986-01-01

    Biological thiols are essential elements in most aspects of cell function but undergo rapid oxidation to disulfides in the presence of oxygen. The evolution of systems to protect against such oxygen toxicity was essential to the emergence of aerobic life. The protection system used by eukaryotes is based upon glutathione (GSH) and GSH-dependent enzymes but many bacteria lack GSH and apparently use other mechanisms. The objective of this research is to elaborate the thiol protective mechanisms employed by prokaryotes of widely divergent evolutionary origin and to understand why GSH became the central thiol employed in essentially all higher organisms. Thiol-selective fluorescent labeling and HPLC analysis has been used to determine key monothiol components.

  13. Does physical activity protect against drug abuse vulnerability?

    PubMed

    Bardo, Michael T; Compton, Wilson M

    2015-08-01

    The current review examined recent literature to determine our state of knowledge about the potential ability of physical activity serve as a protectant against drug abuse vulnerability. Both preclinical and clinical studies were examined using either associational or random assignment study designs. In addition to examining drug use as an outcome variable, the potential neural mediators linking physical activity and drug abuse vulnerability were examined. Several important conclusions may be drawn. First, the preclinical evidence is solid in showing that physical activity in various forms is able to serve as both a preventive and treatment intervention that reduces drug use, although voluntary alcohol drinking appears to be an exception to this conclusion. Second, the clinical evidence provides some evidence, albeit mixed, to suggest a beneficial effect of physical activity on tobacco dependent individuals. In contrast, there exists only circumstantial evidence that physical activity may reduce use of drugs other than nicotine, and there is essentially no solid information from random control studies to know if physical activity may prevent initiation of problem use. Finally, both preclinical and clinical evidence shows that various brain systems are altered by physical activity, with the medial prefrontal cortex (mPFC) serving as one potential node that may mediate the putative link between physical activity and drug abuse vulnerability. It is concluded that novel neurobehavioral approaches taking advantage of novel techniques for assessing the physiological impact of physical activity are needed and can be used to inform the longitudinal random control studies that will answer definitively the question posed. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  14. [Synthesis, solubility, lipids-lowering and liver-protection activities of sulfonated formononetin].

    PubMed

    Wang, Qiu-ya; Meng, Qing-hua; Zhang, Zun-ting; Tian, Zhen-jun; Liu, Hui

    2009-04-01

    A water-soluble compound, sodium formononetin-3'-sulfonate with good lipid-lowering and liver-protection activities was synthesized. It was synthesized by sulfonation reaction, and its structure was characterized by IR, NMR and elemental analyses. The solubility of sodium formononetin-3'-sulfonate in water and n-octanol/water partition coefficient were determined by UV spectrophotometry. The lipid-lowering and liver-protection activities of sodium formononetin-3'-sulfonate were tested by using rat's high fat model induce by feeding with high fat food. The results showed that sodium formononetin-3'-sulfonate not only had favorable water, solubility but also had good lipid-lowering and liver-protection activities.

  15. Self-contained clothing system provides protection against hazardous environments

    NASA Technical Reports Server (NTRS)

    1966-01-01

    Self-contained clothing system protects personnel against hazardous environments. The clothing has an environmental control system and a complete protection envelope consisting of an outer garment, inner garment, underwear, boots, gloves, and helmet.

  16. Requirements for CEC POP Machine Protection System

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pinayev, I.

    2015-02-18

    The requirements of CEC POP machine protection system are meant to prevent damage to a vacuum chamber by a missteered electron beam. In this example, beam energy = 22 MeV, Maximal bunch charge = 5 nC, Maximal repetition rate = 78 kHz, Normalized emittance = 5 mm mrad, Minimal β-function = 1 m. From this information the requirements of the protection system can be calculated by factoring the information into equations to find beam densities and temperature excursions.

  17. The protection of photovoltaic power systems from lightning

    NASA Astrophysics Data System (ADS)

    Rogers, C. B.

    Lightning protection techniques at nine prototype photovoltaic power system sites with outputs from 18-225 kW are described. Noting that protection schemes are devised to fit isokeraunic data for specific sites, grounding is cited as a common feature for all systems. The grounds are, in separate instances, connected to junction boxes, frames of the solar cell panels, lead from the dc center, from the dc negative terminal, from the frames and equipment, at the array turntable, or from the building rebar frames. The dc power cables are protected by either metal conduit, metal conduit ground wire, direct burial, by rigid metal conduit, ground conductors, or by ground conductors at the ends of the conduit run. Costs run from 0.01-0.28$/W, with all the systems outfitted with bypass and blocking diodes. Direct stroke protection is viewed as less important than isokeraunic data.

  18. Ablative Thermal Protection System Fundamentals

    NASA Technical Reports Server (NTRS)

    Beck, Robin A. S.

    2013-01-01

    This is the presentation for a short course on the fundamentals of ablative thermal protection systems. It covers the definition of ablation, description of ablative materials, how they work, how to analyze them and how to model them.

  19. Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation

    PubMed Central

    Hou, Yi-Sheng; Guan, Jun-Jie; Xu, Hai-Dong; Wu, Feng; Sheng, Rui

    2015-01-01

    Dysfunction of the autophagy-lysosomal pathway (ALP) and the ubiquitin-proteasome system (UPS) was thought to be an important pathogenic mechanism in synuclein pathology and Parkinson's disease (PD). In the present study, we investigated the role of sestrin2 in autophagic degradation of α-synuclein and preservation of cell viability in a rotenone-induced cellular model of PD. We speculated that AMP-activated protein kinase (AMPK) was involved in regulation of autophagy and protection of dopaminergic cells against rotenone toxicity by sestrin2. The results showed that both the mRNA and protein levels of sestrin2 were increased in a TP53-dependent manner in Mes 23.5 cells after treatment with rotenone. Genetic knockdown of sestrin2 compromised the autophagy induction in response to rotenone, while overexpression of sestrin2 increased the basal autophagy activity. Sestrin2 presumably enhanced autophagy in an AMPK-dependent fashion, as sestrin2 overexpression activated AMPK, and genetic knockdown of AMPK abrogated autophagy induction by rotenone. Restoration of AMPK activity by metformin after sestrin2 knockdown recovered the autophagy activity. Sestrin2 overexpression ameliorated α-synuclein accumulation, inhibited caspase 3 activation, and reduced the cytotoxicity of rotenone. These results suggest that sestrin2 upregulation attempts to maintain autophagy activity and suppress rotenone cytotoxicity through activation of AMPK, and that sestrin2 exerts a protective effect on dopaminergic cells. PMID:26031332

  20. Cost of wetland protection using cable logging systems

    Treesearch

    Chris B. LeDoux; John E. Baumgras

    1990-01-01

    Forest managers, loggers, land-use planners, and other decision makers need an understanding of estimating the cost of protecting wetlands using cable logging systems to harvest timber products. Results suggest that protection costs can range from $244.75 to $489.50 per acre depending on the degree of protection desired.

  1. 10 CFR 73.50 - Requirements for physical protection of licensed activities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Requirements for physical protection of licensed activities. 73.50 Section 73.50 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS Physical Protection Requirements at Fixed Sites § 73.50 Requirements for physical...

  2. 10 CFR 73.50 - Requirements for physical protection of licensed activities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Requirements for physical protection of licensed activities. 73.50 Section 73.50 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS Physical Protection Requirements at Fixed Sites § 73.50 Requirements for physical...

  3. Passive fire building protection system evaluation (case study: millennium ict centre)

    NASA Astrophysics Data System (ADS)

    Rahman, Vinky; Stephanie

    2018-03-01

    Passive fire protection system is a system that refers to the building design, both regarding of architecture and structure. This system usually consists of structural protection that protects the structure of the building and prevents the spread of fire and facilitate the evacuation process in case of fire. Millennium ICT Center is the largest electronic shopping center in Medan, Indonesia. As a public building that accommodates the crowd, this building needs a fire protection system by the standards. Therefore, the purpose of this study is to evaluate passive fire protection system of Millennium ICT Center building. The study was conducted to describe the facts of the building as well as direct observation to the research location. The collected data is then processed using the AHP (Analytical Hierarchy Process) method in its weighting process to obtain the reliability value of passive fire protection fire system. The results showed that there are some components of passive fire protection system in the building, but some are still unqualified. The first section in your paper

  4. Enhancement of observability and protection of smart power system

    NASA Astrophysics Data System (ADS)

    Siddique, Abdul Hasib

    It is important for a modern power grid to be smarter in order to provide reliable and sustainable supply of electricity. Traditional way of receiving data from the wired system is a very old and outdated technology. For a quicker and better response from the electric system, it is important to look at wireless systems as a feasible option. In order to enhance the observability and protection it is important to integrate wireless technology with the modern power system. In this thesis, wireless network based architecture for wide area monitoring and an alternate method for performing current measurement for protection of generators and motors, has been adopted. There are basically two part of this project. First part deals with the wide area monitoring of the power system and the second part focuses more on application of wireless technology from the protection point of view. A number of wireless method have been adopted in both the part, these includes Zigbee, analog transmission (Both AM and FM) and digital transmission. The main aim of our project was to propose a cost effective wide area monitoring and protection method which will enhance the observability and stability of power grid. A new concept of wireless integration in the power protection system has been implemented in this thesis work.

  5. Active site electrostatics protect genome integrity by blocking abortive hydrolysis during DNA recombination

    PubMed Central

    Ma, Chien-Hui; Rowley, Paul A; Macieszak, Anna; Guga, Piotr; Jayaram, Makkuni

    2009-01-01

    Water, acting as a rogue nucleophile, can disrupt transesterification steps of important phosphoryl transfer reactions in DNA and RNA. We have unveiled this risk, and identified safeguards instituted against it, during strand cleavage and joining by the tyrosine site-specific recombinase Flp. Strand joining is threatened by a latent Flp endonuclease activity (type I) towards the 3′-phosphotyrosyl intermediate resulting from strand cleavage. This risk is not alleviated by phosphate electrostatics; neutralizing the negative charge on the scissile phosphate through methylphosphonate (MeP) substitution does not stimulate type I endonuclease. Rather, protection derives from the architecture of the recombination synapse and conformational dynamics within it. Strand cleavage is protected against water by active site electrostatics. Replacement of the catalytic Arg-308 of Flp by alanine, along with MeP substitution, elicits a second Flp endonuclease activity (type II) that directly targets the scissile phosphodiester bond in DNA. MeP substitution, combined with appropriate active site mutations, will be useful in revealing anti-hydrolytic mechanisms engendered by systems that mediate DNA relaxation, DNA transposition, site-specific recombination, telomere resolution, RNA splicing and retrohoming of mobile introns. PMID:19440204

  6. Protective system for civil buildings and industrial structures subjected to the seismic risk

    NASA Astrophysics Data System (ADS)

    Ghica, D.; Grigore, A.; Ionescu, C.

    2009-04-01

    Romania is a European country with significant seismicity. The most active seismic zone is represented by the Vrancea area, located within the arch of the Carpathians Mountains. Vrancea seismicity is characterized by intermediate depth earthquakes which occur in a narrow epicentral and hypocentral region. During the last 70 years, Romania experienced four strong Vrancea earthquakes: 10 November 1940 (Mw =7.7, 160 km depth), 4 March 1977 (Mw =7.5, 100 km depth), 30 August 1986 (Mw =7.2, 140 km depth), 30 May 30 1990 (Mw =6.9, 80 km depth). The 1977 event was characterized by catastrophic consequences: 1500 casualties and collapsing of 35 high-risk buildings, mostly occurring in Bucharest. The purpose of this paper is to present a protective system designed to be installed in the civil buildings and industrial structures placed in the high seismic regions, and therefore to contribute to the mitigation of the strong earthquake effects on human society. This system proposes an efficient antiseismic protection, respectively shutting down the installations and equipments mounted in the building's infrastructure, which can become extremely dangerous in case of a major earthquake by appearing the possibility of explosions, deflagration, fires, toxic and polluting fluids leakage. The damages are strongly amplified by the fact that, simultaneously, water and electric energy lines distributions are damaged too, making impossible an efficient firemen intervention, for localizing the fire sources. Moreover, the installations of the individual heating stations which operate with open flame increase the risk of explosions inside the buildings during an earthquake. The protective system consists of a seismic switch used for activating through weak-electric-currents of the building's safety systems in case of strong earthquake, especially designed for building's elevators, as well as for moving parts of installations, which require positioning in safety place areas. The originality

  7. A protection system for the JET ITER-like wall based on imaging diagnostics.

    PubMed

    Arnoux, G; Devaux, S; Alves, D; Balboa, I; Balorin, C; Balshaw, N; Beldishevski, M; Carvalho, P; Clever, M; Cramp, S; de Pablos, J-L; de la Cal, E; Falie, D; Garcia-Sanchez, P; Felton, R; Gervaise, V; Goodyear, A; Horton, A; Jachmich, S; Huber, A; Jouve, M; Kinna, D; Kruezi, U; Manzanares, A; Martin, V; McCullen, P; Moncada, V; Obrejan, K; Patel, K; Lomas, P J; Neto, A; Rimini, F; Ruset, C; Schweer, B; Sergienko, G; Sieglin, B; Soleto, A; Stamp, M; Stephen, A; Thomas, P D; Valcárcel, D F; Williams, J; Wilson, J; Zastrow, K-D

    2012-10-01

    The new JET ITER-like wall (made of beryllium and tungsten) is more fragile than the former carbon fiber composite wall and requires active protection to prevent excessive heat loads on the plasma facing components (PFC). Analog CCD cameras operating in the near infrared wavelength are used to measure surface temperature of the PFCs. Region of interest (ROI) analysis is performed in real time and the maximum temperature measured in each ROI is sent to the vessel thermal map. The protection of the ITER-like wall system started in October 2011 and has already successfully led to a safe landing of the plasma when hot spots were observed on the Be main chamber PFCs. Divertor protection is more of a challenge due to dust deposits that often generate false hot spots. In this contribution we describe the camera, data capture and real time processing systems. We discuss the calibration strategy for the temperature measurements with cross validation with thermal IR cameras and bi-color pyrometers. Most importantly, we demonstrate that a protection system based on CCD cameras can work and show examples of hot spot detections that stop the plasma pulse. The limits of such a design and the associated constraints on the operations are also presented.

  8. A protection system for the JET ITER-like wall based on imaging diagnosticsa)

    NASA Astrophysics Data System (ADS)

    Arnoux, G.; Devaux, S.; Alves, D.; Balboa, I.; Balorin, C.; Balshaw, N.; Beldishevski, M.; Carvalho, P.; Clever, M.; Cramp, S.; de Pablos, J.-L.; de la Cal, E.; Falie, D.; Garcia-Sanchez, P.; Felton, R.; Gervaise, V.; Goodyear, A.; Horton, A.; Jachmich, S.; Huber, A.; Jouve, M.; Kinna, D.; Kruezi, U.; Manzanares, A.; Martin, V.; McCullen, P.; Moncada, V.; Obrejan, K.; Patel, K.; Lomas, P. J.; Neto, A.; Rimini, F.; Ruset, C.; Schweer, B.; Sergienko, G.; Sieglin, B.; Soleto, A.; Stamp, M.; Stephen, A.; Thomas, P. D.; Valcárcel, D. F.; Williams, J.; Wilson, J.; Zastrow, K.-D.; JET-EFDA Contributors

    2012-10-01

    The new JET ITER-like wall (made of beryllium and tungsten) is more fragile than the former carbon fiber composite wall and requires active protection to prevent excessive heat loads on the plasma facing components (PFC). Analog CCD cameras operating in the near infrared wavelength are used to measure surface temperature of the PFCs. Region of interest (ROI) analysis is performed in real time and the maximum temperature measured in each ROI is sent to the vessel thermal map. The protection of the ITER-like wall system started in October 2011 and has already successfully led to a safe landing of the plasma when hot spots were observed on the Be main chamber PFCs. Divertor protection is more of a challenge due to dust deposits that often generate false hot spots. In this contribution we describe the camera, data capture and real time processing systems. We discuss the calibration strategy for the temperature measurements with cross validation with thermal IR cameras and bi-color pyrometers. Most importantly, we demonstrate that a protection system based on CCD cameras can work and show examples of hot spot detections that stop the plasma pulse. The limits of such a design and the associated constraints on the operations are also presented.

  9. Advanced Extravehicular Protective System (AEPS) study

    NASA Technical Reports Server (NTRS)

    Williams, J. L.; Webbon, B. W.; Copeland, R. J.

    1972-01-01

    A summary is presented of Advanced Extravehicular Protective Systems (AEPS) for the future missions beyond Skylab in earth orbit, on the lunar surface, and on the Martian surface. The study concentrated on the origination of regenerable life support concepts for use in portable extravehicular protective systems, and included evaluation and comparison with expendable systems, and selection of life support subsystems. The study was conducted in two phases. In the first phase, subsystem concepts for performing life support functions in AEPS which are regenerable or partially regenerable were originated, and in addition, expendable subsystems were considered. Parametric data for each subsystem concept were evolved including subsystem weight and volume, power requirement, thermal control requirement; base regeneration equipment weight and volume, requirement. The second phase involved an evaluation of the impact of safety considerations involving redundant and/or backup systems on the selection of the regenerable life support subsystems. In addition, the impact of the space shuttle program on regenerable life support subsystem development was investigated.

  10. Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.

    PubMed

    Pei, Fen; Li, Hongchun; Henderson, Mark J; Titus, Steven A; Jadhav, Ajit; Simeonov, Anton; Cobanoglu, Murat Can; Mousavi, Seyed H; Shun, Tongying; McDermott, Lee; Iyer, Prema; Fioravanti, Michael; Carlisle, Diane; Friedlander, Robert M; Bahar, Ivet; Taylor, D Lansing; Lezon, Timothy R; Stern, Andrew M; Schurdak, Mark E

    2017-12-19

    Quantitative Systems Pharmacology (QSP) is a drug discovery approach that integrates computational and experimental methods in an iterative way to gain a comprehensive, unbiased understanding of disease processes to inform effective therapeutic strategies. We report the implementation of QSP to Huntington's Disease, with the application of a chemogenomics platform to identify strategies to protect neuronal cells from mutant huntingtin induced death. Using the STHdh Q111 cell model, we investigated the protective effects of small molecule probes having diverse canonical modes-of-action to infer pathways of neuronal cell protection connected to drug mechanism. Several mechanistically diverse protective probes were identified, most of which showed less than 50% efficacy. Specific combinations of these probes were synergistic in enhancing efficacy. Computational analysis of these probes revealed a convergence of pathways indicating activation of PKA. Analysis of phospho-PKA levels showed lower cytoplasmic levels in STHdh Q111 cells compared to wild type STHdh Q7 cells, and these levels were increased by several of the protective compounds. Pharmacological inhibition of PKA activity reduced protection supporting the hypothesis that protection may be working, in part, through activation of the PKA network. The systems-level studies described here can be broadly applied to any discovery strategy involving small molecule modulation of disease phenotype.

  11. 44 CFR 65.14 - Remapping of areas for which local flood protection systems no longer provide base flood protection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... local flood protection systems no longer provide base flood protection. 65.14 Section 65.14 Emergency... § 65.14 Remapping of areas for which local flood protection systems no longer provide base flood protection. (a) General. (1) This section describes the procedures to follow and the types of information...

  12. 44 CFR 65.14 - Remapping of areas for which local flood protection systems no longer provide base flood protection.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... local flood protection systems no longer provide base flood protection. 65.14 Section 65.14 Emergency... § 65.14 Remapping of areas for which local flood protection systems no longer provide base flood protection. (a) General. (1) This section describes the procedures to follow and the types of information...

  13. 44 CFR 65.14 - Remapping of areas for which local flood protection systems no longer provide base flood protection.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... local flood protection systems no longer provide base flood protection. 65.14 Section 65.14 Emergency... § 65.14 Remapping of areas for which local flood protection systems no longer provide base flood protection. (a) General. (1) This section describes the procedures to follow and the types of information...

  14. 14 CFR 29.1359 - Electrical system fire and smoke protection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Electrical Systems and Equipment § 29.1359 Electrical system fire and smoke protection. (a) Components of the electrical system... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Electrical system fire and smoke protection...

  15. Applications of Intelligent Technology to Power System Supervisory Control and Protection Systems

    NASA Astrophysics Data System (ADS)

    Nagata, Takeshi

    Power system supervisory control and protection systems provide utilities with capabilities that are key to a planning business function, i.e., delivering power in a reliable and safe manner. A quality system solution is central to effective operation of a utility's most critical and costly generation, transmission, and distribution assets. The challenging issues for these systems today are not the same as they were few years ago. Today, there is much more placed on integration, use of new IT technologies, and access to information for more purposes. This article presents the topics of intelligent technology to the power system supervisory control and protection systems.

  16. The Serum Complement System: A Simplified Laboratory Exercise to Measure the Activity of an Important Component of the Immune System

    ERIC Educational Resources Information Center

    Inglis, Jordan E.; Radziwon, Kimberly A.; Maniero, Gregory D.

    2008-01-01

    The immune system is a vital physiological component that affords animals protection from disease and is composed of innate and adaptive mechanisms that rely on cellular and dissolved components. The serum complement system is a series of dissolved proteins that protect against a variety of pathogens. The activity of complement in serum can be…

  17. Large thermal protection system panel

    NASA Technical Reports Server (NTRS)

    Weinberg, David J. (Inventor); Myers, Franklin K. (Inventor); Tran, Tu T. (Inventor)

    2003-01-01

    A protective panel for a reusable launch vehicle provides enhanced moisture protection, simplified maintenance, and increased temperature resistance. The protective panel includes an outer ceramic matrix composite (CMC) panel, and an insulative bag assembly coupled to the outer CMC panel for isolating the launch vehicle from elevated temperatures and moisture. A standoff attachment system attaches the outer CMC panel and the bag assembly to the primary structure of the launch vehicle. The insulative bag assembly includes a foil bag having a first opening shrink fitted to the outer CMC panel such that the first opening and the outer CMC panel form a water tight seal at temperatures below a desired temperature threshold. Fibrous insulation is contained within the foil bag for protecting the launch vehicle from elevated temperatures. The insulative bag assembly further includes a back panel coupled to a second opening of the foil bag such that the fibrous insulation is encapsulated by the back panel, the foil bag, and the outer CMC panel. The use of a CMC material for the outer panel in conjunction with the insulative bag assembly eliminates the need for waterproofing processes, and ultimately allows for more efficient reentry profiles.

  18. The Protective Effects of IGF-I against β-Amyloid-related Downregulation of Hippocampal Somatostatinergic System Involve Activation of Akt and Protein Kinase A.

    PubMed

    Aguado-Llera, David; Canelles, Sandra; Frago, Laura M; Chowen, Julie A; Argente, Jesús; Arilla, Eduardo; Barrios, Vicente

    2018-03-15

    Somatostatin (SRIF), a neuropeptide highly distributed in the hippocampus and involved in learning and memory, is markedly reduced in the brain of Alzheimer's disease patients. The effects of insulin-like growth factor-I (IGF-I) against β amyloid (Aβ)-induced neuronal death and associated cognitive disorders have been extensively reported in experimental models of this disease. Here, we examined the effect of IGF-I on the hippocampal somatostatinergic system in Aβ-treated rats and the molecular mechanisms associated with changes in this peptidergic system. Intracerebroventricular Aβ25-35 administration during 14 days (300 pmol/day) to male rats increased Aβ25-35 levels and cell death and markedly reduced SRIF and SRIF receptor 2 levels in the hippocampus. These deleterious effects were associated with reduced Akt and cAMP response element-binding protein (CREB) phosphorylation and activation of c-Jun N-terminal kinase (JNK). Subcutaneous IGF-I co-administration (50 µg/kg/day) reduced hippocampal Aβ25-35 levels, cell death and JNK activation. In addition, IGF-I prevented the reduction in the components of the somatostatinergic system affected by Aβ infusion. Its co-administration also augmented protein kinase A (PKA) activity, as well as Akt and CREB phosphorylation. These results suggest that IGF-I co-administration may have protective effects on the hippocampal somatostatinergic system against Aβ insult through up-regulation of PKA activity and Akt and CREB phosphorylation. Copyright © 2018 IBRO. Published by Elsevier Ltd. All rights reserved.

  19. Mitochondrial Protection and Anti-aging Activity of Astragalus Polysaccharides and Their Potential Mechanism

    PubMed Central

    Li, Xing-Tai; Zhang, Ya-Kui; Kuang, Hai-Xue; Jin, Feng-Xin; Liu, De-Wen; Gao, Ming-Bo; Liu, Ze; Xin, Xiao-Juan

    2012-01-01

    The current study was performed to investigate mitochondrial protection and anti-aging activity of Astragalus polysaccharides (APS) and the potential underlying mechanism. Lipid peroxidation of liver and brain mitochondria was induced by Fe2+–Vit C in vitro. Thiobarbituric acid (TBA) colorimetry was used to measure the content of thiobarbituric acid reactive substances (TBARS). Mouse liver mitochondrial permeability transition (PT) was induced by calcium overload in vitro and spectrophotometry was used to measure it. The scavenging activities of APS on superoxide anion (O2•−) and hydroxyl radical (•OH), which were produced by reduced nicotinamide adenine dinucleotide (NADH)—N-Methylphenazonium methyl sulfate (PMS) and hydrogen peroxide (H2O2)–Fe2+ system respectively, were measured by 4-nitrobluetetrazolium chloride (NBT) reduction and Fenton reaction colorimetry respectively. The Na2S2O3 titration method was used to measure the scavenging activities of APS on H2O2. APS could inhibit TBARS production, protect mitochondria from PT, and scavenge O2•−, •OH and H2O2 significantly in a concentration-dependent manner respectively. The back of the neck of mice was injected subcutaneously with D-galactose to induce aging at a dose of 100 mg/kg/d for seven weeks. Moreover, the activities of catalase (CAT), surperoxide dismutase (SOD) and glutathione peroxidase (GPx) and anti-hydroxyl radical which were assayed by using commercial monitoring kits were increased significantly in vivo by APS. According to this research, APS protects mitochondria by scavenging reactive oxygen species (ROS), inhibiting mitochondrial PT and increasing the activities of antioxidases. Therefore, APS has the effect of promoting health. PMID:22408421

  20. A digital protection system incorporating knowledge based learning

    NASA Astrophysics Data System (ADS)

    Watson, Karan; Russell, B. Don; McCall, Kurt

    A digital system architecture used to diagnoses the operating state and health of electric distribution lines and to generate actions for line protection is presented. The architecture is described functionally and to a limited extent at the hardware level. This architecture incorporates multiple analysis and fault-detection techniques utilizing a variety of parameters. In addition, a knowledge-based decision maker, a long-term memory retention and recall scheme, and a learning environment are described. Preliminary laboratory implementations of the system elements have been completed. Enhanced protection for electric distribution feeders is provided by this system. Advantages of the system are enumerated.

  1. Protective activity of green tea against free radical- and glucose-mediated protein damage.

    PubMed

    Nakagawa, Takako; Yokozawa, Takako; Terasawa, Katsutoshi; Shu, Seiji; Juneja, Lekh Raj

    2002-04-10

    Protein oxidation and glycation are posttranslational modifications that are implicated in the pathological development of many age-related disease processes. This study investigated the effects of green tea extract, and a green tea tannin mixture and its components, on protein damage induced by 2,2'-azobis(2-amidinopropane) dihydrochloride (a free radical generator) and glucose in in vitro assay systems. We found that green tea extract can effectively protect against protein damage, and showed that its action is mainly due to tannin. In addition, it was shown that the chemical structures of tannin components are also involved in this activity, suggesting that the presence of the gallate group at the 3 position plays the most important role in the protective activity against protein oxidation and glycation, and that there is also a contribution by the hydroxyl group at the 5' position in the B ring and the sterical structure. These findings demonstrate the mechanisms of the usefulness of green tea in protein oxidation- and glycation-associated diseases.

  2. Anode protection system for shutdown of solid oxide fuel cell system

    DOEpatents

    Li, Bob X; Grieves, Malcolm J; Kelly, Sean M

    2014-12-30

    An Anode Protection Systems for a SOFC system, having a Reductant Supply and safety subsystem, a SOFC anode protection subsystem, and a Post Combustion and slip stream control subsystem. The Reductant Supply and safety subsystem includes means for generating a reducing gas or vapor to prevent re-oxidation of the Ni in the anode layer during the course of shut down of the SOFC stack. The underlying ammonia or hydrogen based material used to generate a reducing gas or vapor to prevent the re-oxidation of the Ni can be in either a solid or liquid stored inside a portable container. The SOFC anode protection subsystem provides an internal pressure of 0.2 to 10 kPa to prevent air from entering into the SOFC system. The Post Combustion and slip stream control subsystem provides a catalyst converter configured to treat any residual reducing gas in the slip stream gas exiting from SOFC stack.

  3. Technological Innovation in Grade Crossing Protective Systems

    DOT National Transportation Integrated Search

    1971-06-01

    The constraints on innovative grade crossing protective systems are delineated and guidelines for development indicated. Inventory data has been arranged to permit an estimate of the classes of systems needed, the allowable costs, and contribution of...

  4. Electromagnetic shielding of thermal protection system for hypersonic vehicles

    NASA Astrophysics Data System (ADS)

    Albano, M.; Micheli, D.; Gradoni, G.; Morles, R. B.; Marchetti, M.; Moglie, F.; Mariani Primiani, V.

    2013-06-01

    The numerical simulation and the measurement of electromagnetic shielding at microwave frequencies of thermal protection system for hypersonic vehicles is presented using nested reverberation chamber. An example of a possible thermal protection system for a re-entry vehicle is presented. This system based on carbon material is electromagnetically characterized. The characterization takes into account not only the materials but also the final assembly configuration of the thermal protection system. The frequency range is 2-8 GHz. The results of measurements and simulations show that the microwave shielding effectiveness of carbon materials is above 60 dB for a single tile and that the tile inter-distance is able to downgrade the shielding effectiveness on the average to about 40 dB.

  5. 33 CFR 127.1507 - Water systems for fire protection.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Water systems for fire protection... HAZARDOUS GAS Waterfront Facilities Handling Liquefied Hazardous Gas Firefighting Equipment § 127.1507 Water systems for fire protection. (a) Each waterfront facility handling LHG must have a supply of water and a...

  6. Physiological evaluation of men wearing three different toxicological protective systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Levine, L.; Cadarette, B.S.; Sawka, M.N.

    1989-08-01

    This study examined the physiological responses of seven volunteers exercising in the heat while wearing three different toxicological protective systems. The Toxicological Agent Protective (TAP) suit has been available for use for more than 30 years while the other two protective systems are developmental efforts. The Self-Contained Toxicological Environmental Protection Outfit (STEPO) includes either a backpack-rebreather (with CO{sub 2} scrubber) and ice-cooling vest (STEPO-R), or a tether system which supplies breathing/cooling air inside the suit (STEPO-T). After the volunteers were heat acclimated, the three toxicological protection systems were evaluated utilizing a counter-balanced experimental design initially in a hot and thenmore » in a cool environment while subjects walked at 1.12 m/s, 0% grade for an attempted two hours. There was no statistical advantage of any one system in terms of exercise time in the cool environment. While evaporated sweating rate was greater for the STEPO-T in the cool environment compared to both STEPO-R and TAP. Development efforts to improve the STEPO system designs continue, and physiological evaluation of new developmental models is underway.« less

  7. Active Protection of an MgB2 Test Coil

    PubMed Central

    Park, Dong Keun; Hahn, Seungyong; Bascuñán, Juan; Iwasa, Yukikazu

    2011-01-01

    This paper presents results of a study, experimental and computational, of a detect-and-activate-the-heater protection technique applied to a magnesium diboride (MgB2) test coil operated in semi-persistent mode. The test coil with a winding ID of 25 cm and wound with ~500-m long reacted MgB2 wire was operated at 4.2 K immersed in a bath of liquid helium. In this active technique, upon the initiation of a “hot spot” of a length ~10 cm, induced by a “quench heater,” a “protection heater” (PH) of ~600-cm long planted within the test coil is activated. The normal zone created by the PH is large enough to absorb the test coil’s entire initial stored energy and still keeps the peak temperature within the winding below ~260 K. PMID:22081754

  8. An Intrusion Detection System for the Protection of Railway Assets Using Fiber Bragg Grating Sensors

    PubMed Central

    Catalano, Angelo; Bruno, Francesco Antonio; Pisco, Marco; Cutolo, Antonello; Cusano, Andrea

    2014-01-01

    We demonstrate the ability of Fiber Bragg Gratings (FBGs) sensors to protect large areas from unauthorized activities in railway scenarios such as stations or tunnels. We report on the technological strategy adopted to protect a specific depot, representative of a common scenario for security applications in the railway environment. One of the concerns in the protection of a railway area centers on the presence of rail-tracks, which cannot be obstructed with physical barriers. We propose an integrated optical fiber system composed of FBG strain sensors that can detect human intrusion for protection of the perimeter combined with FBG accelerometer sensors for protection of rail-track access. Several trials were carried out in indoor and outdoor environments. The results demonstrate that FBG strain sensors bonded under a ribbed rubber mat enable the detection of intruder break-in via the pressure induced on the mat, whereas the FBG accelerometers installed under the rails enable the detection of intruders walking close to the railroad tracks via the acoustic surface waves generated by footsteps. Based on a single enabling technology, this integrated system represents a valuable intrusion detection system for railway security and could be integrated with other sensing functionalities in the railway field using fiber optic technology. PMID:25268920

  9. Wireless Subsurface Sensors for Health Monitoring of Thermal Protection Systems on Hypersonic Vehicles

    NASA Technical Reports Server (NTRS)

    Milos, Frank S.; Arnold, Jim (Technical Monitor)

    2001-01-01

    Health diagnostics is an area where major improvements have been identified for potential implementation into the design of new reusable launch vehicles (RLVs) in order to reduce life cycle costs, to increase safety margins, and to improve mission reliability. NASA Ames is leading the effort to develop inspection and health management technologies for thermal protection systems. This paper summarizes a joint project between NASA Ames and industry partners to develop "wireless" devices that can be embedded in the thermal protection system to monitor temperature or other quantities of interest. These devices are sensors integrated with radio-frequency identification (RFID) microchips to enable non-contact communication of sensor data to an external reader that may be a hand-held scanner or a large portal. Both passive and active prototype devices have been developed. The passive device uses a thermal fuse to indicate the occurrence of excessive temperature. This device has a diameter under 0.13 cm. (suitable for placement in gaps between ceramic TPS tiles on an RLV) and can withstand 370 C for 15 minutes. The active device contains a small battery to provide power to a thermocouple for recording a temperature history during flight. The bulk of the device must be placed beneath the TPS for protection from high temperature, but the thermocouple can be placed in a hot location such as near the external surface.

  10. Magnetic field generated by lightning protection system

    NASA Astrophysics Data System (ADS)

    Geri, A.; Veca, G. M.

    1988-04-01

    A lightning protection system for today's civil buildings must be electromagnetically compatible with the electronic equipment present in the building. This paper highlights a mathematic model which analyzes the electromagnetic effects in the environment in which the lightning protection system is. This model is developed by means of finite elements of an electrical circuit where each element is represented by a double pole circuit according to the trapezoidal algorithm developed using the finite difference method. It is thus possible to analyze the electromagnetic phenomena associated with the transient effects created by the lightning stroke even for a high-intensity current. Referring to an elementary system comprised of an air terminal, a down conductor, and a ground terminal, numerical results are here laid out.

  11. Fast breeder reactor protection system

    DOEpatents

    van Erp, J.B.

    1973-10-01

    Reactor protection is provided for a liquid-metal-fast breeder reactor core by measuring the coolant outflow temperature from each of the subassemblies of the core. The outputs of the temperature sensors from a subassembly region of the core containing a plurality of subassemblies are combined in a logic circuit which develops a scram alarm if a predetermined number of the sensors indicate an over temperature condition. The coolant outflow from a single subassembly can be mixed with the coolant outflow from adjacent subassemblies prior to the temperature sensing to increase the sensitivity of the protection system to a single subassembly failure. Coherence between the sensors can be required to discriminate against noise signals. (Official Gazette)

  12. Pre-stressed thermal protection systems

    NASA Technical Reports Server (NTRS)

    Dunn, T. J. (Inventor)

    1984-01-01

    A hexagonal protective and high temperature resistant system for the Space Shuttle Orbiter consists of a multiplicity of pockets formed by hexagonally oriented spacer bars secured on the vehicle substructure. A packing of low density insulating batt material 18 in each pocket, and a thin protective panel of laterally resilient advanced carbon-carbon material surmounting the peripherals bars and packing. Each panel has three stepped or offset lips on contiguous edges. At the center of each pocket is a fully insulated stanchion secured to and connecting the substructure and panel for flexing the panel toward the substructure and thereby prestressing the panel and forcing the panel edges firmly against the spacer bars.

  13. The impact of mining activities on Mongolia's protected areas: a status report with policy recommendations.

    PubMed

    Farrington, John D

    2005-07-01

    Mongolia's protected areas cover 20.5 million ha or 13.1% of its national territory. Existing and proposed protected areas, however, are threatened by mining. Mining impacts on Mongolia's protected areas are diverse and include licensed and unlicensed mineral activities in protected areas, buffer zone disturbance, and prevention of the establishment of proposed protected areas. Review of United States, Canadian, and Australian policies revealed 9 basic approaches to resolving conflicts between protected areas and mining. Four approaches suitable for Mongolia are granting land trades and special dispensations in exchange for mineral licenses in protected areas; granting protected status to all lapsed mineral licenses in protected areas; voluntary forfeiting of mineral licenses in protected areas in exchange for positive corporate publicity; and prohibiting all new mineral activities in existing and proposed protected areas. Mining is Mongolia's most important industry, however, and the long-term benefits of preserving Mongolia's natural heritage must be considered and weighed against the economic benefits and costs of mining activities.

  14. The gnotobiotic brine shrimp (Artemia franciscana) model system reveals that the phenolic compound pyrogallol protects against infection through its prooxidant activity.

    PubMed

    Baruah, Kartik; Duy Phong, Ho Phuong Pham; Norouzitallab, Parisa; Defoirdt, Tom; Bossier, Peter

    2015-12-01

    The phenolic compound pyrogallol is the functional unit of many polyphenols and currently there has been a growing interest in using this compound in human and animal health owing to its health-promoting effects. The biological actions of pyrogallol moiety (and polyphenols) in inducing health benefitting effects have been studied; however, the mechanisms of action remain unclear yet. Here, we aimed at unravelling the underlying mechanism of action behind the protective effects of pyrogallol against bacterial infection by using the gnotobiotically-cultured brine shrimp Artemia franciscana and pathogenic bacteria Vibrio harveyi as host-pathogen model system. The gnotobiotic test system represents an exceptional system for carrying out such studies because it eliminates any possible interference of microbial communities (naturally present in the experimental system) in mechanistic studies and furthermore facilitates the interpretation of the results in terms of a cause effect relationship. We provided clear evidences suggesting that pyrogallol pretreament, at an optimum concentration, induced protective effects in the brine shrimp against V. harveyi infection. By pretreating brine shrimp with pyrogallol in the presence or absence of an antioxidant enzyme mixture (catalase and superoxide dismutase), we showed that the Vibrio-protective effect of the compound was caused by its prooxidant action (e.g. generation of hydrogen peroxide, H2O2). We showed further that generation of prooxidant is linked to the induction of heat shock protein Hsp70, which is involved in eliciting the prophenoloxidase and transglutaminase immune responses. The ability of pyrogallol to induce protective immunity makes it a potential natural protective agent that might be a potential preventive modality for different host-pathogen systems. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. [Study on protective effect of Tianji soft capsule on blood lipids, internal antioxidant system and vascular endothelial system in hyperlipidemia rats].

    PubMed

    Ma, Hai-ying; Chen, Jin-yao; Zhang, Li-shi

    2011-11-01

    To study the protective effects of Tianji soft capsule (TJSC) on blood lipids, internal antioxidant system and vascular endothelial system in hyperlipidemia rats. Seventy two healthy male rats were divided into six groups. The rats in control group were administered with ordinary diet. The rats in model group were fed with high cholesterol/lipid diet to induce hyperlipidemia. The rats in TJSC and CoQ10 groups were fed with high cholesterol/lipid diet, and treated with TJSC at different doses of 83 (low-dose group, L), 250 (middle-dose group, M), 750 (high-dose group, H) mg/kg, and CoQ10 at the dose of 83 mg/kg, respectively. All animals were put to death after four weeks, effects on lipid level; antioxidant system and endothelial system were evaluated through detection of total cholesterol (TC), triglyceride (TG), very low density lipoprotein (VLDL), atherogenic index (AI), malondidehyde (MDA) and plasma endothelin (ET), HDL/TC ratio, activities of superoxide dismutase (SOD) and nitric oxide (NO). Compared with model group, serum TC, TG, VLDL, AI, MDA and ET reduced and the HDL/TC ratio increased, meanwhile activities of SOD and NO were enhanced. TJSC can regulate the lipid metabolism, enhance antioxidant system and protect the vascular endothelia system in hyperlipiemic rats.

  16. Real World Data Driven Evolution of Volvo Cars’ Side Impact Protection Systems and their Effectiveness

    PubMed Central

    Jakobsson, Lotta; Lindman, Magdalena; Svanberg, Bo; Carlsson, Henrik

    2010-01-01

    This study analyses the outcome of the continuous improved occupant protection over the last two decades for front seat near side occupants in side impacts based on a real world driven working process. The effectiveness of four generations of improved side impact protection are calculated based on data from Volvo’s statistical accident database of Volvo Cars in Sweden. Generation I includes vehicles with a new structural and interior concept (SIPS). Generation II includes vehicles with structural improvements and a new chest airbag (SIPSbag). Generation III includes vehicles with further improved SIPS and SIPSbag as well as the new concept with a head protecting Inflatable Curtain (IC). Generation IV includes the most recent vehicles with further improvements of all the systems plus advanced sensors and seat belt pretensioner activation. Compared to baseline vehicles, vehicles of generation I reduce MAIS2+ injuries by 54%, generation II by 61% and generation III by 72%. For generation IV effectiveness figures cannot be calculated because of the lack of MAIS2+ injuries. A continuous improved performance is also seen when studying the AIS2+ pelvis, abdomen, chest and head injuries separately. By using the same real world driven working process, future improvements and possibly new passive as well as active safety systems, will be developed with the aim of further improved protection to near side occupants in side impacts. PMID:21050597

  17. ICRP Publication 138: Ethical Foundations of the System of Radiological Protection.

    PubMed

    Cho, K-W; Cantone, M-C; Kurihara-Saio, C; Le Guen, B; Martinez, N; Oughton, D; Schneider, T; Toohey, R; ZöLzer, F

    2018-02-01

    Despite a longstanding recognition that radiological protection is not only a matter of science, but also ethics, ICRP publications have rarely addressed the ethical foundations of the system of radiological protection explicitly. The purpose of this publication is to describe how the Commission has relied on ethical values, either intentionally or indirectly, in developing the system of radiological protection with the objective of presenting a coherent view of how ethics is part of this system. In so doing, it helps to clarify the inherent value judgements made in achieving the aim of the radiological protection system as underlined by the Commission in Publication 103. Although primarily addressed to the radiological protection community, this publication is also intended to address authorities, operators, workers, medical professionals, patients, the public, and its representatives (e.g. NGOs) acting in the interest of the protection of people and the environment. This publication provides the key steps concerning the scientific, ethical, and practical evolutions of the system of radiological protection since the first ICRP publication in 1928. It then describes the four core ethical values underpinning the present system: beneficence/ non-maleficence, prudence, justice, and dignity. It also discusses how these core ethical values relate to the principles of radiological protection, namely justification, optimisation, and limitation. The publication finally addresses key procedural values that are required for the practical implementation of the system, focusing on accountability, transparency, and inclusiveness. The Commission sees this publication as a founding document to be elaborated further in different situations and circumstances.

  18. Intelligent, Self-Diagnostic Thermal Protection System for Future Spacecraft

    NASA Technical Reports Server (NTRS)

    Hyers, Robert W.; SanSoucie, Michael P.; Pepyne, David; Hanlon, Alaina B.; Deshmukh, Abhijit

    2005-01-01

    The goal of this project is to provide self-diagnostic capabilities to the thermal protection systems (TPS) of future spacecraft. Self-diagnosis is especially important in thermal protection systems (TPS), where large numbers of parts must survive extreme conditions after weeks or years in space. In-service inspections of these systems are difficult or impossible, yet their reliability must be ensured before atmospheric entry. In fact, TPS represents the greatest risk factor after propulsion for any transatmospheric mission. The concepts and much of the technology would be applicable not only to the Crew Exploration Vehicle (CEV), but also to ablative thermal protection for aerocapture and planetary exploration. Monitoring a thermal protection system on a Shuttle-sized vehicle is a daunting task: there are more than 26,000 components whose integrity must be verified with very low rates of both missed faults and false positives. The large number of monitored components precludes conventional approaches based on centralized data collection over separate wires; a distributed approach is necessary to limit the power, mass, and volume of the health monitoring system. Distributed intelligence with self-diagnosis further improves capability, scalability, robustness, and reliability of the monitoring subsystem. A distributed system of intelligent sensors can provide an assurance of the integrity of the system, diagnosis of faults, and condition-based maintenance, all with provable bounds on errors.

  19. The SHEFEX II Thermal Protection System

    NASA Astrophysics Data System (ADS)

    Bohrk, H.; Elsaber, H.; Weihs, H.

    2011-05-01

    The SHEFEXII payload tip is ready for flight. Within a period of three years, the experiment has been designed, laid out, parts have been manufactured, mounted and instrumented for the upcoming flight in autumn 2011. The present paper gives an overview over the thermal protection system (TPS) of the SHEFEX II vehicle including the TPS-material, the overall TPS-setup, and detailed informations on the faceted ther- mal protection including the gap seal, the sharp leading edge, the transpiration-cooling experiment AKTIV, and the aerodynamic control surfaces, i.e. canards.

  20. Thermal Management and Thermal Protection Systems

    NASA Technical Reports Server (NTRS)

    Hasnain, Aqib

    2016-01-01

    During my internship in the Thermal Design Branch (ES3), I contributed to two main projects: i) novel passive thermal management system for future human exploration, ii) AVCOAT undercut thermal analysis. i) As NASA prepares to further expand human and robotic presence in space, it is well known that spacecraft architectures will be challenged with unprecedented thermal environments. Future exploration activities will have the need of thermal management systems that can provide higher reliability, mass and power reduction and increased performance. In an effort to start addressing the current technical gaps the NASA Johnson Space Center Passive Thermal Discipline has engaged in technology development activities. One of these activities was done through an in-house Passive Thermal Management System (PTMS) design for a lunar lander. The proposed PTMS, functional in both microgravity and gravity environments, consists of three main components: a heat spreader, a novel hybrid wick Variable Conductance Heat Pipe (VCHP), and a radiator. The aim of this PTMS is to keep electronics on a vehicle within their temperature limits (0 and 50 C for the current design) during all mission phases including multiple lunar day/night cycles. The VCHP was tested to verify its thermal performance. I created a thermal math model using Thermal Desktop (TD) and analyzed it to predict the PTMS performance. After testing, the test data provided a means to correlate the thermal math model. This correlation took into account conduction and convection heat transfer, representing the actual benchtop test. Since this PTMS is proposed for space missions, a vacuum test will be taking place to provide confidence that the system is functional in space environments. Therefore, the model was modified to include a vacuum chamber with a liquid nitrogen shroud while taking into account conduction and radiation heat transfer. Infrared Lamps were modelled and introduced into the model to simulate the sun

  1. Advanced microprocessor based power protection system using artificial neural network techniques

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chen, Z.; Kalam, A.; Zayegh, A.

    This paper describes an intelligent embedded microprocessor based system for fault classification in power system protection system using advanced 32-bit microprocessor technology. The paper demonstrates the development of protective relay to provide overcurrent protection schemes for fault detection. It also describes a method for power fault classification in three-phase system based on the use of neural network technology. The proposed design is implemented and tested on a single line three phase power system in power laboratory. Both the hardware and software development are described in detail.

  2. European activities in radiation protection in medicine.

    PubMed

    Simeonov, Georgi

    2015-07-01

    The recently published Council Directive 2013/59/Euratom ('new European Basic Safety Standards', EU BSS) modernises and consolidates the European radiation protection legislation by taking into account the latest scientific knowledge, technological progress and experience with implementing the current legislation and by merging five existing Directives into a single piece of legislation. The new European BSS repeal previous European legislation on which the national systems for radiation protection in medicine of the 28 European Union (EU) Member States are based, including the 96/29/Euratom 'BSS' and the 97/43/Euratom 'Medical Exposure' Directives. While most of the elements of the previous legislation have been kept, there are several legal changes that will have important influence over the regulation and practice in the field all over Europe-these include, among others: (i) strengthening the implementation of the justification principle and expanding it to medically exposed asymptomatic individuals, (ii) more attention to interventional radiology, (iii) new requirements for dose recording and reporting, (iv) increased role of the medical physics expert in imaging, (v) new set of requirements for preventing and following up on accidents and (vi) new set of requirements for procedures where radiological equipment is used on people for non-medical purposes (non-medical imaging exposure). The EU Member States have to enforce the new EU BSS before January 2018 and bring into force the laws, regulations and administrative provisions necessary to comply with it. The European Commission has certain legal obligations and powers to verify the compliance of the national measures with the EU laws and, wherever necessary, issue recommendations to, or open infringement cases against, national governments. In order to ensure timely and coordinated implementation of the new European legal requirements for radiation protection, the Commission is launching several actions

  3. Active immunity induced by passive IgG post-exposure protection against ricin.

    PubMed

    Hu, Charles Chen; Yin, Junfei; Chau, Damon; Cherwonogrodzky, John W; Hu, Wei-Gang

    2014-01-21

    Therapeutic antibodies can confer an instant protection against biothreat agents when administered. In this study, intact IgG and F(ab')2 from goat anti-ricin hyperimmune sera were compared for the protection against lethal ricin mediated intoxication. Similar ricin-binding affinities and neutralizing activities in vitro were observed between IgG and F(ab')2 when compared at the same molar concentration. In a murine ricin intoxication model, both IgG and F(ab')2 could rescue 100% of the mice by one dose (3 nmol) administration of antibodies 1 hour after 5 × LD50 ricin challenge. Nine days later, when the rescued mice received a second ricin challenge (5 × LD50), only the IgG-treated mice survived; the F(ab')2-treated mice did not. The experimental design excluded the possibility of residual goat IgG responsible for the protection against the second ricin challenge. Results confirmed that the active immunity against ricin in mice was induced quickly following the passive delivery of a single dose of goat IgG post-exposure. Furthermore, it was demonstrated that the induced active immunity against ricin in mice lasted at least 5 months. Therefore, passive IgG therapy not only provides immediate protection to the victim after ricin exposure, but also elicits an active immunity against ricin that subsequently results in long term protection.

  4. Active Immunity Induced by Passive IgG Post-Exposure Protection against Ricin

    PubMed Central

    Hu, Charles Chen; Yin, Junfei; Chau, Damon; Cherwonogrodzky, John W.; Hu, Wei-Gang

    2014-01-01

    Therapeutic antibodies can confer an instant protection against biothreat agents when administered. In this study, intact IgG and F(ab’)2 from goat anti-ricin hyperimmune sera were compared for the protection against lethal ricin mediated intoxication. Similar ricin-binding affinities and neutralizing activities in vitro were observed between IgG and F(ab’)2 when compared at the same molar concentration. In a murine ricin intoxication model, both IgG and F(ab’)2 could rescue 100% of the mice by one dose (3 nmol) administration of antibodies 1 hour after 5 × LD50 ricin challenge. Nine days later, when the rescued mice received a second ricin challenge (5 × LD50), only the IgG-treated mice survived; the F(ab’)2-treated mice did not. The experimental design excluded the possibility of residual goat IgG responsible for the protection against the second ricin challenge. Results confirmed that the active immunity against ricin in mice was induced quickly following the passive delivery of a single dose of goat IgG post-exposure. Furthermore, it was demonstrated that the induced active immunity against ricin in mice lasted at least 5 months. Therefore, passive IgG therapy not only provides immediate protection to the victim after ricin exposure, but also elicits an active immunity against ricin that subsequently results in long term protection. PMID:24451844

  5. Assessment of anti-oxidant activity of plant extracts using microbial test systems.

    PubMed

    Oktyabrsky, O; Vysochina, G; Muzyka, N; Samoilova, Z; Kukushkina, T; Smirnova, G

    2009-04-01

    To evaluate the anti-oxidant properties of extracts from 20 medicinal herbs growing in western Siberia using microbial test systems and different in vitro methods. In vivo anti-oxidant activity of extracts was evaluated for their capacity to protect bacteria, Escherichia coli, against bacteriostatic and bactericidal effects of H(2)O(2) and menadione, and action on anti-oxidant gene expression. In vitro anti-oxidant activity has been examined by a number of methods including: the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH(*))-scavenging assay, chelating activity and capacity to protect plasmid DNA against oxidative damage. In addition, total polyphenol content was determined. The extracts of Fragaria vesca, Rosa majalis, Pentaphylloides fruticosa, Alchemilla vulgaris and Pulmonaria mollis possessed the highest levels of anti-oxidant activity in vivo and in vitro. The protective properties were more closely related to the DPPH(*) radical-scavenging activity, tannin content and action on anti-oxidant gene expression than to other parameters. The extracts of medicinal plants may have anti-oxidant effects on bacteria simultaneously through several different pathways, including direct inhibition of reactive oxygen species, iron chelation and anti-oxidant genes induction. Using microbial test systems, we revealed herbs that may be used as potential sources of natural anti-oxidants.

  6. 75 FR 68370 - Agency Information Collection Activities: Office of Infrastructure Protection; Chemical Security...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ... DEPARTMENT OF HOMELAND SECURITY National Protection and Programs Directorate [Docket No. DHS-2010-0071] Agency Information Collection Activities: Office of Infrastructure Protection; Chemical Security...: The Department of Homeland Security (DHS), National Protection and Programs Directorate (NPPD), Office...

  7. Revitalizing the Space Shuttle's Thermal Protection System with Reverse Engineering and 3D Vision Technology

    NASA Technical Reports Server (NTRS)

    Wilson, Brad; Galatzer, Yishai

    2008-01-01

    The Space Shuttle is protected by a Thermal Protection System (TPS) made of tens of thousands of individually shaped heat protection tile. With every flight, tiles are damaged on take-off and return to earth. After each mission, the heat tiles must be fixed or replaced depending on the level of damage. As part of the return to flight mission, the TPS requirements are more stringent, leading to a significant increase in heat tile replacements. The replacement operation requires scanning tile cavities, and in some cases the actual tiles. The 3D scan data is used to reverse engineer each tile into a precise CAD model, which in turn, is exported to a CAM system for the manufacture of the heat protection tile. Scanning is performed while other activities are going on in the shuttle processing facility. Many technicians work simultaneously on the space shuttle structure, which results in structural movements and vibrations. This paper will cover a portable, ultra-fast data acquisition approach used to scan surfaces in this unstable environment.

  8. 20 CFR 1002.19 - What activity is protected from employer retaliation by USERRA?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false What activity is protected from employer retaliation by USERRA? 1002.19 Section 1002.19 Employees' Benefits OFFICE OF THE ASSISTANT SECRETARY FOR... Employer Discrimination and Retaliation § 1002.19 What activity is protected from employer retaliation by...

  9. 20 CFR 1002.19 - What activity is protected from employer retaliation by USERRA?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false What activity is protected from employer retaliation by USERRA? 1002.19 Section 1002.19 Employees' Benefits OFFICE OF THE ASSISTANT SECRETARY FOR... Employer Discrimination and Retaliation § 1002.19 What activity is protected from employer retaliation by...

  10. 20 CFR 1002.19 - What activity is protected from employer retaliation by USERRA?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What activity is protected from employer retaliation by USERRA? 1002.19 Section 1002.19 Employees' Benefits OFFICE OF THE ASSISTANT SECRETARY FOR... Employer Discrimination and Retaliation § 1002.19 What activity is protected from employer retaliation by...

  11. 20 CFR 1002.19 - What activity is protected from employer retaliation by USERRA?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false What activity is protected from employer retaliation by USERRA? 1002.19 Section 1002.19 Employees' Benefits OFFICE OF THE ASSISTANT SECRETARY FOR... Employer Discrimination and Retaliation § 1002.19 What activity is protected from employer retaliation by...

  12. Commercial-Aircraft Protection System

    NASA Astrophysics Data System (ADS)

    Case, Russell L., Jr.; Wolff, Peter H.

    2004-09-01

    Recent world events have identified needs for a commercial aircraft defense system against Man-Portable Air Defense Systems (MANPADS), such as SA-7 and Stinger shoulder launched surface-to-air missiles. Technical challenges include target detection, identification and countermeasures. Political and societal challenges include cost, time to deployment, ground and air safety, and reliability. These challenges, as well as many others, have been met and overcome with the development of Thor Systems' Commercial-Aircraft Protection System (C-APS). C-APS makes use of commercial technology such as radar and infrared sensors with a laser-based countermeasure. Unlike adapted military systems, C-APS detects the threat long before the military versions by employing a 360 degree hemispherical scan, identifying the threat with an infrared sensor and employing a directed laser to not only deflect the target but to permanently disable its seeker. Enhanced capabilities include multiple threat elimination and closed-loop technology for kill verification. All of this is accomplished with development costs less than half that required to convert military technology, manufacturing costs significantly less than competitive products, and a maintenance cycle coincident with standard FAA requirements, which are significantly longer than current systems.

  13. Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3

    PubMed Central

    Wu, Kenneth K.

    2010-01-01

    Peroxisome proliferator-activated receptors (PPARs) were reported to prevent cells from stress-induced apoptosis and protect tissues against ischemia-reperfusion injury. The underlying transcriptional mechanism is unclear. Recent reports indicate that the antiapoptotic actions of ligand-activated PPARδ and PPARγ are mediated through enhanced binding of PPAR to the promoter of 14-3-3ε and upregulation of 14-3-3ε expression. We propose that ligand-activated PPARα exerts its anti-apoptotic actions via the identical pathway. The PPAR to 14-3-3 transcriptional axis plays an important role in protection of cell and tissue integrity and is a target for drug discovery. PMID:20862376

  14. Stream protection with small cable yarding systems

    Treesearch

    Penn A. Peters; Chris B. LeDoux

    1984-01-01

    Small cable yarder systems that can be purchased and operated by independent logging contractors have less potential negative impact on water quality than ground-based systems operating on steep terrain because they do not require such an intense road system. Stream protection costs were estimated at $3.78 per lineal foot of stream when a typical small yarder (Koller K...

  15. Flood Protection Decision Making Within a Coupled Human and Natural System

    NASA Astrophysics Data System (ADS)

    O'Donnell, Greg; O'Connell, Enda

    2013-04-01

    Due to the perceived threat from climate change, prediction under changing climatic and hydrological conditions has become a dominant theme of hydrological research. Much of this research has been climate model-centric, in which GCM/RCM climate projections have been used to drive hydrological system models to explore potential impacts that should inform adaptation decision-making. However, adaptation fundamentally involves how humans may respond to increasing flood and drought hazards by changing their strategies, activities and behaviours which are coupled in complex ways to the natural systems within which they live and work. Humans are major agents of change in hydrological systems, and representing human activities and behaviours in coupled human and natural hydrological system models is needed to gain insight into the complex interactions that take place, and to inform adaptation decision-making. Governments and their agencies are under pressure to make proactive investments to protect people living in floodplains from the perceived increasing flood hazard. However, adopting this as a universal strategy everywhere is not affordable, particularly in times of economic stringency and given uncertainty about future climatic conditions. It has been suggested that the assumption of stationarity, which has traditionally been invoked in making hydrological risk assessments, is no longer tenable. However, before the assumption of hydrologic nonstationarity is accepted, the ability to cope with the uncertain impacts of global warming on water management via the operational assumption of hydrologic stationarity should be carefully examined. Much can be learned by focussing on natural climate variability and its inherent changes in assessing alternative adaptation strategies. A stationary stochastic multisite flood hazard model has been developed that can exhibit increasing variability/persistence in annual maximum floods, starting with the traditional assumption of

  16. Fault-tolerant reactor protection system

    DOEpatents

    Gaubatz, Donald C.

    1997-01-01

    A reactor protection system having four divisions, with quad redundant sensors for each scram parameter providing input to four independent microprocessor-based electronic chassis. Each electronic chassis acquires the scram parameter data from its own sensor, digitizes the information, and then transmits the sensor reading to the other three electronic chassis via optical fibers. To increase system availability and reduce false scrams, the reactor protection system employs two levels of voting on a need for reactor scram. The electronic chassis perform software divisional data processing, vote 2/3 with spare based upon information from all four sensors, and send the divisional scram signals to the hardware logic panel, which performs a 2/4 division vote on whether or not to initiate a reactor scram. Each chassis makes a divisional scram decision based on data from all sensors. Each division performs independently of the others (asynchronous operation). All communications between the divisions are asynchronous. Each chassis substitutes its own spare sensor reading in the 2/3 vote if a sensor reading from one of the other chassis is faulty or missing. Therefore the presence of at least two valid sensor readings in excess of a set point is required before terminating the output to the hardware logic of a scram inhibition signal even when one of the four sensors is faulty or when one of the divisions is out of service.

  17. Robotic system for the servicing of the orbiter thermal protection system

    NASA Technical Reports Server (NTRS)

    Graham, Todd; Bennett, Richard; Dowling, Kevin; Manouchehri, Davoud; Cooper, Eric; Cowan, Cregg

    1994-01-01

    This paper describes the design and development of a mobile robotic system to process orbiter thermal protection system (TPS) tiles. This work was justified by a TPS automation study which identified tile rewaterproofing and visual inspection as excellent applications for robotic automation.

  18. Field joint environmental protection system vibration/pressurization qualification

    NASA Technical Reports Server (NTRS)

    Cook, M.

    1989-01-01

    The procedures used and results obtained from vibration testing the redesigned solid rocket motor (RSRM) field joint environmental protection system (FJEPS), hereafter referred to as the joint protection system (JPS) are documented. The major purposes were to certify that the flight-designed JPS will withstand the dynamic environmental conditions of the redesigned solid rocket booster, and to certify that the cartridge check valve (vent valve) will relieve pressure build-up under the JPS during the initial 120 sec of flight. Also, an evaluation of the extruded cork insulation bonding was performed after the vibration testing.

  19. Remote monitoring of a Fire Protection System

    NASA Astrophysics Data System (ADS)

    Bauman, Steven; Vermeulen, Tom; Roberts, Larry; Matsushige, Grant; Gajadhar, Sarah; Taroma, Ralph; Elizares, Casey; Arruda, Tyson; Potter, Sharon; Hoffman, James

    2011-03-01

    Some years ago CFHT proposed developing a Remote Observing Environment aimed at producing Science Observations at their Observatory Facility on Mauna Kea from their Headquarters facility in Waimea, HI. This Remote Observing Project commonly referred to as OAP (Observatory Automation Project) was completed at the end of January 2011 and has been providing the majority of Science Data since. My poster will discuss the upgrades to the existing fire alarm protection system. With no one at the summit during nightly operations, the observatory facility required automated monitoring of the facility for safety to personnel and equipment in the case of a fire. An addressable analog fire panel was installed which utilizes digital communication protocol (DCP), intelligent communication with other devices, and an RS-232 interface which provides feedback and real-time monitoring of the system. Using the interface capabilities of the panel, it provides notifications when heat detectors, smoke sensors, manual pull stations, or the main observatory computer room fire suppression system has been activated. The notifications are sent out as alerts to staff in the form of test massages and emails and the observing control GUI interface alerts the remote telescope operator with a map showing the location of the fire occurrence and type of device that has been triggered. And all of this was accomplished without the need for an outside vendor to monitor the system and facilitate warnings or notifications regarding the system.

  20. Active thermography in qualitative evaluation of protective materials.

    PubMed

    Gralewicz, Grzegorz; Wiecek, Bogusław

    2009-01-01

    This is a study of the possibilities of a qualitative evaluation of protective materials with active thermography. It presents a simulation of a periodic excitation of a multilayer composite material. Tests were conducted with lock-in thermography on Kevlar composite consisting of 16 layers of Kevlar fabric reinforced with formaldehyde resin with implanted delamination defects. Lock-in thermography is a versatile tool for nondestructive evaluation. It is a fast, remote and nondestructive procedure. Hence, it was used to detect delaminations in the composite structure of materials used in the production of components designed for personal protection. This method directly contributes to an improvement in safety.

  1. Joint force protection advanced security system (JFPASS) "the future of force protection: integrate and automate"

    NASA Astrophysics Data System (ADS)

    Lama, Carlos E.; Fagan, Joe E.

    2009-09-01

    The United States Department of Defense (DoD) defines 'force protection' as "preventive measures taken to mitigate hostile actions against DoD personnel (to include family members), resources, facilities, and critical information." Advanced technologies enable significant improvements in automating and distributing situation awareness, optimizing operator time, and improving sustainability, which enhance protection and lower costs. The JFPASS Joint Capability Technology Demonstration (JCTD) demonstrates a force protection environment that combines physical security and Chemical, Biological, Radiological, Nuclear, and Explosive (CBRNE) defense through the application of integrated command and control and data fusion. The JFPASS JCTD provides a layered approach to force protection by integrating traditional sensors used in physical security, such as video cameras, battlefield surveillance radars, unmanned and unattended ground sensors. The optimization of human participation and automation of processes is achieved by employment of unmanned ground vehicles, along with remotely operated lethal and less-than-lethal weapon systems. These capabilities are integrated via a tailorable, user-defined common operational picture display through a data fusion engine operating in the background. The combined systems automate the screening of alarms, manage the information displays, and provide assessment and response measures. The data fusion engine links disparate sensors and systems, and applies tailored logic to focus the assessment of events. It enables timely responses by providing the user with automated and semi-automated decision support tools. The JFPASS JCTD uses standard communication/data exchange protocols, which allow the system to incorporate future sensor technologies or communication networks, while maintaining the ability to communicate with legacy or existing systems.

  2. Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis.

    PubMed

    Lin, Wensheng; Lin, Yifeng; Li, Jin; Fenstermaker, Ali G; Way, Sharon W; Clayton, Benjamin; Jamison, Stephanie; Harding, Heather P; Ron, David; Popko, Brian

    2013-04-03

    There is compelling evidence that oligodendrocyte apoptosis, in response to CNS inflammation, contributes significantly to the development of the demyelinating disorder multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). Therefore, approaches designed to protect oligodendrocytes would likely have therapeutic value. Activation of pancreatic endoplasmic reticulum kinase (PERK) signaling in response to endoplasmic reticulum (ER) stress increases cell survival under various cytotoxic conditions. Moreover, there is evidence that PERK signaling is activated in oligodendrocytes within demyelinating lesions in multiple sclerosis and EAE. Our previous study demonstrated that CNS delivery of the inflammatory cytokine interferon-γ before EAE onset protected mice against EAE, and this protection was dependent on PERK signaling. In our current study, we sought to elucidate the role of PERK signaling in oligodendrocytes during EAE. We generated transgenic mice that allow for temporally controlled activation of PERK signaling, in the absence of ER stress, specifically in oligodendrocytes. We demonstrated that persistent activation of PERK signaling was not deleterious to oligodendrocyte viability or the myelin of adult animals. Importantly, we found that enhanced activation of PERK signaling specifically in oligodendrocytes significantly attenuated EAE disease severity, which was associated with reduced oligodendrocyte apoptosis, demyelination, and axonal degeneration. This effect was not the result of an altered degree of the inflammatory response in EAE mice. Our results provide direct evidence that activation of PERK signaling in oligodendrocytes is cytoprotective, protecting mice against EAE.

  3. A demonstrator for an integrated subway protection system

    NASA Astrophysics Data System (ADS)

    Detoma, E.; Capetti, P.; Casati, G.; Billington, S.

    2008-04-01

    In 2006 SEPA has carried on the installation and tests of a demonstrator for an integrated subway protection system at a new subway station in the Naples, Italy) metropolitan area. Protection of a subway system is a difficult task given the amount of passengers transported every day. The demonstrator has been limited to non-intrusive detection techniques not to impair the passenger flow into the station. The demonstrator integrates several technologies and products that have been developed by SEPA or are already available on the market (MKS Instruments,...). The main purpose is to provide detection capabilities for attempts to introduce radioactive substances in the subway station, in order to foil possible attempts to place a dirty bomb, and threat detection and identification following release of chemical agents. The system integrates additional sensors such as video surveillance cameras and air flow sensing to complement the basic sensors suite. The need to protect sensitive installations such as subway stations has been highlighted by the series of terroristics actions carried out in recent years in the subway in London. However, given the number of passengers of a metro system, it is impossible to propose security techniques operating in ways similar to the screening of passengers in airports. Passengers screening and threat detection and identification must be quick, non-intrusive and capable of screening a large number of passengers to be applicable to mass transit systems. In 2005 SEPA, a small company operating in the field of trains video-surveillance systems and radiation detectors, started developing an integrated system to provide a comprehensive protection to subway stations, based on ready available or off-the-shelf components in order to quickly develop a reliable system with available technology. We ruled out at the beginning any new development in order to speed up the fielding of the system in less than one year. The system was developed with

  4. Multisensor system for the protection of critical infrastructure of a seaport

    NASA Astrophysics Data System (ADS)

    Kastek, Mariusz; Dulski, Rafał; Zyczkowski, Marek; Szustakowski, Mieczysław; Trzaskawka, Piotr; Ciurapinski, Wiesław; Grelowska, Grazyna; Gloza, Ignacy; Milewski, Stanislaw; Listewnik, Karol

    2012-06-01

    There are many separated infrastructural objects within a harbor area that may be considered "critical", such as gas and oil terminals or anchored naval vessels. Those objects require special protection, including security systems capable of monitoring both surface and underwater areas, because an intrusion into the protected area may be attempted using small surface vehicles (boats, kayaks, rafts, floating devices with weapons and explosives) as well as underwater ones (manned or unmanned submarines, scuba divers). The paper will present the concept of multisensor security system for a harbor protection, capable of complex monitoring of selected critical objects within the protected area. The proposed system consists of a command centre and several different sensors deployed in key areas, providing effective protection from land and sea, with special attention focused on the monitoring of underwater zone. The initial project of such systems will be presented, its configuration and initial tests of the selected components. The protection of surface area is based on medium-range radar and LLTV and infrared cameras. Underwater zone will be monitored by a sonar and acoustic and magnetic barriers, connected into an integrated monitoring system. Theoretical analyses concerning the detection of fast, small surface objects (such as RIB boats) by a camera system and real test results in various weather conditions will also be presented.

  5. Rebamipide induces the gastric mucosal protective factor, cyclooxygenase-2, via activation of 5'-AMP-activated protein kinase.

    PubMed

    Lee, Sunyoung; Jeong, Seongkeun; Kim, Wooseong; Kim, Dohoon; Yang, Yejin; Yoon, Jeong-Hyun; Kim, Byung Joo; Min, Do Sik; Jung, Yunjin

    2017-01-29

    Rebamipide, an amino acid derivative of 2(1H)-quinolinone, has been used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. Induction of cyclooxygenase (COX)-2, a gastric mucosal protective factor, by rebamipide has been suggested as the major mechanism of the drug action. However, how rebamipide induces COX-2 at the molecular level needs further investigation. In this study, the molecular mechanism underlying the induction of COX-2 by rebamipide was investigated. In gastric carcinoma cells and macrophage cells, rebamipide induced phosphorylation of AMP-activated protein kinase (AMPK), leading to phosphorylation of acetyl-CoA carboxylase (ACC), a substrate of AMPK. The induction of COX-2 by rebamipide was dependent on AMPK activation because compound C, an AMPK inhibitor, abolished COX-2 induction by rebamipide. In a mouse ulcer model, rebamipide protected against hydrochloric acid/ethanol-induced gastric ulcer, and these protective effects were deterred by co-administration of compound C. In parallel, in the gastric tissues, rebamipide increased the phosphorylation AMPK, whereas compound C reduced the levels of COX-2 and phosphorylated ACC, which were increased by rebamipide. Taken together, the activation of AMPK by rebamipide may be a molecular mechanism that contributes to induction of COX-2, probably resulting in protection against gastric ulcers. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. Topologically protected modes in non-equilibrium stochastic systems.

    PubMed

    Murugan, Arvind; Vaikuntanathan, Suriyanarayanan

    2017-01-10

    Non-equilibrium driving of biophysical processes is believed to enable their robust functioning despite the presence of thermal fluctuations and other sources of disorder. Such robust functions include sensory adaptation, enhanced enzymatic specificity and maintenance of coherent oscillations. Elucidating the relation between energy consumption and organization remains an important and open question in non-equilibrium statistical mechanics. Here we report that steady states of systems with non-equilibrium fluxes can support topologically protected boundary modes that resemble similar modes in electronic and mechanical systems. Akin to their electronic and mechanical counterparts, topological-protected boundary steady states in non-equilibrium systems are robust and are largely insensitive to local perturbations. We argue that our work provides a framework for how biophysical systems can use non-equilibrium driving to achieve robust function.

  7. Under-Body Blast Mitigation: Stand-Alone Seat Safety Activation System

    DTIC Science & Technology

    2014-04-01

    Restraints, Airbags or other protection systems) to mitigate injury to the occupant during the onset of the event. Injuries may occur as soon as 2.5 ms...cost-effective sensor to accurately and consistently deploy airbags and other pyrotechnic restraint systems based on accelerometers and other...Circuitry are critically important in order to activate the initiators of air bags and pyrotechnic restraint system such as airbags at the very first

  8. Degradation and protection of DNAzymes on human skin.

    PubMed

    Marquardt, Kay; Eicher, Anna-Carola; Dobler, Dorota; Höfer, Frank; Schmidts, Thomas; Schäfer, Jens; Renz, Harald; Runkel, Frank

    2016-10-01

    DNAzymes are catalytic nucleic acid based molecules that have become a new class of active pharmaceutical ingredients (API). Until now, five DNAzymes have entered clinical trials. Two of them were tested for topical application, whereby dermally applied DNAzymes had been prone to enzymatic degradation. To protect the DNAzymes the enzymatic activity of human skin has to be examined. Therefore, the enzymatic activity of human skin was qualitatively and quantitatively analyzed. Activity similar to that of DNase II could be identified and the specific activity was determined to be 0.59Units/mg. These results were used to develop an in vitro degradation assay to screen different kinds of protective systems on human skin. The chosen protective systems consisted of biodegradable chitosans or polyethylenimine, which forms polyplexes when combined with DNAzymes. The polyplexes were characterized in terms of particle size, zeta potential, stability and degree of complexation. The screening revealed that the protective efficiency of the polyplexes depended on the polycation and the charge ratio (ξ). At a critical ξ ratio between 1.0 and 4.1 and at a maximal zeta potential, sufficient protection of the DNAzyme was achieved. The results of this study will be helpful for the development of a protective dermal drug delivery systems using polyplexes. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. Data fusion concept in multispectral system for perimeter protection of stationary and moving objects

    NASA Astrophysics Data System (ADS)

    Ciurapiński, Wieslaw; Dulski, Rafal; Kastek, Mariusz; Szustakowski, Mieczyslaw; Bieszczad, Grzegorz; Życzkowski, Marek; Trzaskawka, Piotr; Piszczek, Marek

    2009-09-01

    The paper presents the concept of multispectral protection system for perimeter protection for stationary and moving objects. The system consists of active ground radar, thermal and visible cameras. The radar allows the system to locate potential intruders and to control an observation area for system cameras. The multisensor construction of the system ensures significant improvement of detection probability of intruder and reduction of false alarms. A final decision from system is worked out using image data. The method of data fusion used in the system has been presented. The system is working under control of FLIR Nexus system. The Nexus offers complete technology and components to create network-based, high-end integrated systems for security and surveillance applications. Based on unique "plug and play" architecture, system provides unmatched flexibility and simplistic integration of sensors and devices in TCP/IP networks. Using a graphical user interface it is possible to control sensors and monitor streaming video and other data over the network, visualize the results of data fusion process and obtain detailed information about detected intruders over a digital map. System provides high-level applications and operator workload reduction with features such as sensor to sensor cueing from detection devices, automatic e-mail notification and alarm triggering.

  10. Racial Disparity in Minnesota's Child Protection System

    ERIC Educational Resources Information Center

    Johnson, Erik P.; Clark, Sonja; Donald, Matthew; Pedersen, Rachel; Pichotta, Catherine

    2007-01-01

    Minnesota has been recognized by several studies as a state with a significant amount of racial disparity in its child protection system. This study, using 2001 data from Minnesota's Social Services Information Service, was conducted to determine at which of the six decision points in Minnesota's child welfare system racial disparities are…

  11. Radiological Protection and Nuclear Engineering Studies in Multi-MW Target Systems

    NASA Astrophysics Data System (ADS)

    Luis, Raul Fernandes

    Several innovative projects involving nuclear technology have emerged around the world in recent years, for applications such as spallation neutron sources, accelerator-driven systems for the transmutation of nuclear waste and radioactive ion beam (RIB) production. While the available neutron Wuxes from nuclear reactors did not increase substantially in intensity over the past three decades, the intensities of neutron sources produced in spallation targets have increased steadily, and should continue to do so during the 21st century. Innovative projects like ESS, MYRRHA and EURISOL lie at the forefront of the ongoing pursuit for increasingly bright neutron sources; driven by proton beams with energies up to 2 GeV and intensities up to several mA, the construction of their proposed facilities involves complex Nuclear Technology and Radiological Protection design studies executed by multidisciplinary teams of scientists and engineers from diUerent branches of Science. The intense neutron Wuxes foreseen for those facilities can be used in several scientiVc research Velds, such as Nuclear Physics and Astrophysics, Medicine and Materials Science. In this work, the target systems of two facilitites for the production of RIBs using the Isotope Separation On-Line (ISOL) method were studied in detail: ISOLDE, operating at CERN since 1967, and EURISOL, the next-generation ISOL facility to be built in Europe. For the EURISOL multi-MW target station, a detailed study of Radiological Protection was carried out using the Monte Carlo code FLUKA. Simulations were done to assess neutron Wuences, Vssion rates, ambient dose equivalent rates during operation and after shutdown and the production of radioactive nuclei in the targets and surrounding materials. DiUerent materials were discussed for diUerent components of the target system, aiming at improving its neutronics performance while keeping the residual activities resulting from material activation as low as possible. The second

  12. EPA Funds New England State Activities Protecting Against Asbestos in School Buildings

    EPA Pesticide Factsheets

    New England states received a total of $631,000 from the US Environmental Protection Agency this year to fund activities designed to protect students, teachers and other people in school buildings from the health threats of asbestos.

  13. The role of privacy protection in healthcare information systems adoption.

    PubMed

    Hsu, Chien-Lung; Lee, Ming-Ren; Su, Chien-Hui

    2013-10-01

    Privacy protection is an important issue and challenge in healthcare information systems (HISs). Recently, some privacy-enhanced HISs are proposed. Users' privacy perception, intention, and attitude might affect the adoption of such systems. This paper aims to propose a privacy-enhanced HIS framework and investigate the role of privacy protection in HISs adoption. In the proposed framework, privacy protection, access control, and secure transmission modules are designed to enhance the privacy protection of a HIS. An experimental privacy-enhanced HIS is also implemented. Furthermore, we proposed a research model extending the unified theory of acceptance and use of technology by considering perceived security and information security literacy and then investigate user adoption of a privacy-enhanced HIS. The experimental results and analyses showed that user adoption of a privacy-enhanced HIS is directly affected by social influence, performance expectancy, facilitating conditions, and perceived security. Perceived security has a mediating effect between information security literacy and user adoption. This study proposes several implications for research and practice to improve designing, development, and promotion of a good healthcare information system with privacy protection.

  14. Protected areas as social-ecological systems: perspectives from resilience and social-ecological systems theory.

    PubMed

    Cumming, Graeme S; Allen, Craig R

    2017-09-01

    Conservation biology and applied ecology increasingly recognize that natural resource management is both an outcome and a driver of social, economic, and ecological dynamics. Protected areas offer a fundamental approach to conserving ecosystems, but they are also social-ecological systems whose ecological management and sustainability are heavily influenced by people. This editorial, and the papers in the invited feature that it introduces, discuss three emerging themes in social-ecological systems approaches to understanding protected areas: (1) the resilience and sustainability of protected areas, including analyses of their internal dynamics, their effectiveness, and the resilience of the landscapes within which they occur; (2) the relevance of spatial context and scale for protected areas, including such factors as geographic connectivity, context, exchanges between protected areas and their surrounding landscapes, and scale dependency in the provision of ecosystem services; and (3) efforts to reframe what protected areas are and how they both define and are defined by the relationships of people and nature. These emerging themes have the potential to transform management and policy approaches for protected areas and have important implications for conservation, in both theory and practice. © 2017 by the Ecological Society of America.

  15. Protected areas as social-ecological systems: perspectives from resilience and social-ecological systems theory

    USGS Publications Warehouse

    Cumming, Graeme S.; Allen, Craig R.

    2017-01-01

    Conservation biology and applied ecology increasingly recognize that natural resource management is both an outcome and a driver of social, economic, and ecological dynamics. Protected areas offer a fundamental approach to conserving ecosystems, but they are also social-ecological systems whose ecological management and sustainability are heavily influenced by people. This editorial, and the papers in the invited feature that it introduces, discuss three emerging themes in social-ecological systems approaches to understanding protected areas: (1) the resilience and sustainability of protected areas, including analyses of their internal dynamics, their effectiveness, and the resilience of the landscapes within which they occur; (2) the relevance of spatial context and scale for protected areas, including such factors as geographic connectivity, context, exchanges between protected areas and their surrounding landscapes, and scale dependency in the provision of ecosystem services; and (3) efforts to reframe what protected areas are and how they both define and are defined by the relationships of people and nature. These emerging themes have the potential to transform management and policy approaches for protected areas and have important implications for conservation, in both theory and practice.

  16. Protective Effects of Hydroxychloroquine against Accelerated Atherosclerosis in Systemic Lupus Erythematosus

    PubMed Central

    Cauli, Alberto

    2018-01-01

    Cardiovascular (CV) morbidity and mortality are a challenge in management of patients with systemic lupus erythematosus (SLE). Higher risk of CV disease in SLE patients is mostly related to accelerated atherosclerosis. Nevertheless, high prevalence of traditional cardiovascular risk factors in SLE patients does not fully explain the increased CV risk. Despite the pathological bases of accelerated atherosclerosis are not fully understood, it is thought that this process is driven by the complex interplay between SLE and atherosclerosis pathogenesis. Hydroxychloroquine (HCQ) is a cornerstone in treatment of SLE patients and has been thought to exert a broad spectrum of beneficial effects on disease activity, prevention of damage accrual, and mortality. Furthermore, HCQ is thought to protect against accelerated atherosclerosis targeting toll-like receptor signaling, cytokine production, T-cell and monocyte activation, oxidative stress, and endothelial dysfunction. HCQ was also described to have beneficial effects on traditional CV risk factors, such as dyslipidemia and diabetes. In conclusion, despite lacking randomized controlled trials unambiguously proving the protection of HCQ against accelerated atherosclerosis and incidence of CV events in SLE patients, evidence analyzed in this review is in favor of its beneficial effect. PMID:29670462

  17. Advanced Extravehicular Protective Systems (AEPS) study

    NASA Technical Reports Server (NTRS)

    Williams, J. L.; Copeland, R. J.; Webbon, B. W.

    1971-01-01

    A description is given of life support subsystem concepts for advanced extravehicular protective systems (AEPS) intended for use on future orbital, lunar surface, and Mars surface missions in the late 1970's and 1980's. Primary interest was centered around the thermal control and carbon dioxide control subsystems because they offer the greatest potential for total weight savings. Emphasis was placed on the generation of regenerable subsystem concepts; however, partially regenerable and expendable concepts were also considered. Previously conceived and developed subsystem concepts were included in the study. Concepts were evaluated on the basis of subsystem weight and volume, and subsystem contribution to parent vehicle weight and volume, which included spares, regeneration equipment, expendables, expandables storage penalty, power penalty, and process heating or cooling penalty. Results are presented showing total weight and volume penalty as a function of total mission extravehicular activity (EVA) hours, and showing EVA weight and volume as a function of EVA duration. Subsystem concepts are recommended for each life support function, and secondary concepts which should be developed are also identified.

  18. AntogomiR-451 protects human gastric epithelial cells from ethanol via activating AMPK signaling.

    PubMed

    Zhu, Huanhuan; Zhang, Linjie; Xu, Jianmin; Zhu, Chunhua; Zhao, Hui; Zhu, Yongkang; Lv, Guoqiang

    2018-02-26

    The prevention and treatment efficiency of ethanol-induced gastric epithelial injury are not satisfied. We have previously shown that AMP-activated protein kinase (AMPK) activation exerts a pro-survival function in human gastric epithelial cells (GECs). miroRNA-451 ("miR-451")'s inhibitor, antagomiR-451, can activate AMPK signaling. In the present study, we show that forced-expression of antagomiR-451 via a lentiviral vector depleted miR-451, leading to AMPK activation in established GES-1 cells and primary human GECs. AntagomiR-451 efficiently protected GES-1 cells and primary human GECs from ethanol-induced viability reduction and apoptosis. AMPK activation is required for antagomiR-451-induced GEC protection. AMPKα1 knockdown (by targeted-shRNAs) or knockout (by CRISPR-Cas-9 KO plasmid) blocked antagomiR-451-induced AMPK activation, and GEC protection against ethanol. Further experimental results show that antagomiR-451 significantly attenuated ethanol-induced reactive oxygen species (ROS) production, lipid peroxidation and DNA damage. Collectively, antagomiR-451 protects human GECs from ethanol via activating AMPK signaling. Copyright © 2018 Elsevier Inc. All rights reserved.

  19. Advanced Protected Services: A Concept Paper on Survivable Service-Oriented Systems

    DTIC Science & Technology

    2010-05-07

    resiliency and protection of such systems to a level where they can withstand sustained attacks from well-motivated adversaries. In this paper we...that are designed for the protection of systems that are based on service-oriented architectures. 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF...resilient against malicious attacks , and to demonstrate the utility of the developed advanced protection techniques in settings that exhibit various

  20. Lightning protection of a modern wind energy system

    NASA Astrophysics Data System (ADS)

    Jaeger, D.

    Due to their considerable height and frequent location above flat terrain, wind energy systems may be struck by lightning, with two types of severe effects: the physical destruction of structurally and/or mechanically important elements, such as a rotor blade, or the damage or interruption of system electrical and electronic equipment. The GROWIAN II DEMO lightning protection program has undertaken the development of measures which in their sophistication and complexity approximate those for aircraft. These protective measures are applied to the carbon fiber-reinforced plastic composite rotor blades, the rotor bearing, and electrical circuitry installed within the wind turbine's nacelle.

  1. The complexity of child protection recurrence: The case for a systems approach.

    PubMed

    Jenkins, Brian Q; Tilbury, Clare; Mazerolle, Paul; Hayes, Hennessey

    2017-01-01

    Research on child protection recurrence has found consistent child, family, and case characteristics associated with repeated involvement with the child protection system. Despite the considerable body of empirical research, knowledge about why recurrence occurs, and what can be done to reduce it, is limited. This paper reviews the empirical literature and analyses the approaches of prior recurrence research. Four related conceptual challenges are identified: (1) a tendency to conflate child protection recurrence with repeated child maltreatment; (2) uncertainty about how best to operationalize and measure child protection recurrence in research; (3) inconsistency between prevailing explanations for the most frequently observed patterns of recurrence; and (4) difficulty in developing coherent strategies to address child protection recurrence based on research. Addressing these challenges requires a greater consideration of the effects of decision-making in the child protection system on recurrence. This paper proposes a methodology based in systems theory and drawing on existing administrative data to examine the characteristics of the child protection system that may also produce recurrence. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Protect Minnesota's Agricultural Land: Components and Activities for Elementary Students.

    ERIC Educational Resources Information Center

    Noy, Laura

    An endeavor to alert elementary teachers and students to the need to protect and conserve one of Minnesota's basic resources, soil, these supplementary instructional activities are designed for easy integration into science, social studies, language arts, mathematics, and art subject and skill areas. Each activity includes a brief description of…

  3. Fault-tolerant reactor protection system

    DOEpatents

    Gaubatz, D.C.

    1997-04-15

    A reactor protection system is disclosed having four divisions, with quad redundant sensors for each scram parameter providing input to four independent microprocessor-based electronic chassis. Each electronic chassis acquires the scram parameter data from its own sensor, digitizes the information, and then transmits the sensor reading to the other three electronic chassis via optical fibers. To increase system availability and reduce false scrams, the reactor protection system employs two levels of voting on a need for reactor scram. The electronic chassis perform software divisional data processing, vote 2/3 with spare based upon information from all four sensors, and send the divisional scram signals to the hardware logic panel, which performs a 2/4 division vote on whether or not to initiate a reactor scram. Each chassis makes a divisional scram decision based on data from all sensors. Each division performs independently of the others (asynchronous operation). All communications between the divisions are asynchronous. Each chassis substitutes its own spare sensor reading in the 2/3 vote if a sensor reading from one of the other chassis is faulty or missing. Therefore the presence of at least two valid sensor readings in excess of a set point is required before terminating the output to the hardware logic of a scram inhibition signal even when one of the four sensors is faulty or when one of the divisions is out of service. 16 figs.

  4. Active suppression induced by repetitive self-epitopes protects against EAE development.

    PubMed

    Puentes, Fabiola; Dickhaut, Katharina; Hofstätter, Maria; Falk, Kirsten; Rötzschke, Olaf

    2013-01-01

    Autoimmune diseases result from a breakdown in self-tolerance to autoantigens. Self-tolerance is induced and sustained by central and peripheral mechanisms intended to deviate harmful immune responses and to maintain homeostasis, where regulatory T cells play a crucial role. The use of self-antigens in the study and treatment of a range of autoimmune diseases has been widely described; however, the mechanisms underlying the induced protection by these means are unclear. This study shows that protection of experimental autoimmune disease induced by T cell self-epitopes in a multimerized form (oligomers) is mediated by the induction of active suppression. The experimental autoimmune encephalomyelitis (EAE) animal model for multiple sclerosis was used to study the mechanisms of protection induced by the treatment of oligomerized T cell epitope of myelin proteolipid protein (PLP139-151). Disease protection attained by the administration of oligomers was shown to be antigen specific and effective in both prevention and treatment of ongoing EAE. Oligomer mediated tolerance was actively transferred by cells from treated mice into adoptive hosts. The induction of active suppression was correlated with the recruitment of cells in the periphery associated with increased production of IL-10 and reduction of the pro-inflammatory cytokine TNF-α. The role of suppressive cytokines was demonstrated by the reversion of oligomer-induced protection after in vivo blocking of either IL-10 or TGF-β cytokines. This study strongly supports an immunosuppressive role of repeat auto-antigens to control the development of EAE with potential applications in vaccination and antigen specific treatment of autoimmune diseases.

  5. Protection of tokamak plasma facing components by a capillary porous system with lithium

    NASA Astrophysics Data System (ADS)

    Lyublinski, I.; Vertkov, A.; Mirnov, S.; Lazarev, V.

    2015-08-01

    Development of plasma facing material (PFM) based on the Capillary-Porous System (CPS) with lithium and activity on realization of lithium application strategy are addressed to meet the challenges under the creation of steady-state tokamak fusion reactor and fusion neutron source. Presented overview of experiSystem" and "Capillary-Pore System" in the document. Please check, and correct if necessary.->mental study of lithium CPS in plasma devices demonstrates the progress in protection of tokamak plasma facing components (PFC) from damage, stabilization and self-renewal of liquid lithium surface, elimination of plasma pollution and lithium accumulation in tokamak chamber. The possibility of PFC protection from the high power load related to cooling of the tokamak boundary plasma by radiation of non-fully stripped lithium ions supported by experimental results. This approach demonstrated in scheme of closed loops of Li circulation in the tokamak vacuum chamber and realized in a series of design of tokamak in-vessel elements.

  6. Stem cell factor (SCF) protects osteoblasts from oxidative stress through activating c-Kit-Akt signaling

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yang, Lei; Wu, Zhong; Yin, Gang

    2014-12-12

    Highlights: • SCF receptor c-Kit is functionally expressed in primary and transformed osteoblasts. • SCF protects primary and transformed osteoblasts from H{sub 2}O{sub 2}. • SCF activation of c-Kit in osteoblasts, required for its cyto-protective effects. • c-Kit mediates SCF-induced Akt activation in cultured osteoblasts. • Akt activation is required for SCF-regulated cyto-protective effects in osteoblasts. - Abstract: Osteoblasts regulate bone formation and remodeling, and are main target cells of oxidative stress in the progression of osteonecrosis. The stem cell factor (SCF)-c-Kit pathway plays important roles in the proliferation, differentiation and survival in a range of cell types, but littlemore » is known about its functions in osteoblasts. In this study, we found that c-Kit is functionally expressed in both osteoblastic-like MC3T3-E1 cells and primary murine osteoblasts. Its ligand SCF exerted significant cyto-protective effects against hydrogen peroxide (H{sub 2}O{sub 2}). SCF activated its receptor c-Kit in osteoblasts, which was required for its cyto-protective effects against H{sub 2}O{sub 2}. Pharmacological inhibition (by Imatinib and Dasatinib) or shRNA-mediated knockdown of c-Kit thus inhibited SCF-mediated osteoblast protection. Further investigations showed that protection by SCF against H{sub 2}O{sub 2} was mediated via activation of c-Kit-dependent Akt pathway. Inhibition of Akt activation, through pharmacological or genetic means, suppressed SCF-mediated anti-H{sub 2}O{sub 2} activity in osteoblasts. In summary, we have identified a new SCF-c-Kit-Akt physiologic pathway that protects osteoblasts from H{sub 2}O{sub 2}-induced damages, and might minimize the risk of osteonecrosis caused by oxidative stress.« less

  7. Multiple corrosion protection systems for reinforced concrete bridge components.

    DOT National Transportation Integrated Search

    2007-07-01

    Eleven systems combining epoxy-coated reinforcement with another corrosion protection system are evaluated using : the rapid macrocell, Southern Exposure, cracked beam, and linear polarization resistance tests. The systems include : bars that are pre...

  8. Hazards in the Solar System: Out-of-School Time Student Activities Focused on Engineering Protective Space Gloves

    NASA Astrophysics Data System (ADS)

    Vaughan, R. G.; Meyer, N.; Anderson, R. B.; Sokol, K.; Nolan, B.; Edgar, L. A.; Gaither, T. A.; Milazzo, M. P.; Clark, J.

    2017-12-01

    "In Good Hands: Engineering Space Gloves" is a new Engineering Adventures® curriculum unit created for students in grades 3-5 in out-of-school time programs. It was designed and created by the Engineering is Elementary® team at the Museum of Science in Boston, MA, in collaboration with subject matter experts at the USGS Astrogeology Science Center and teacher professional development experts at Northern Arizona University's Center for Science Teaching and Learning. As part of the NASA-funded PLANETS (Planetary Learning that Advances the Nexus of Engineering, Technology, and Science) project, the goals for this unit are to introduce students to some of the potential hazards that would be faced by astronauts exploring planetary bodies in the solar system, and to engage students in thinking about how to engineer solutions to these challenges. Potential human health hazards in planetary exploration include: little to no breathable oxygen, exposure to extreme temperatures and pressures, radiation, dusty or toxic environments, and/or high velocity debris. First, students experiment with gloves made of different materials to accomplish tasks like picking up paper clips, entering numbers on a calculator, and using simple tools, while also testing for insulating properties, protection from crushing forces, and resistance to dust contamination. Students explore the trade-offs between form and multiple desired functions, and gain an introduction to materials engineering. Students are then presented with three different missions. Mission 1 is to collect and return a sample from Saturn's moon, Titan; Mission 2 is mining asteroids for useful minerals; and Mission 3 is to build a radio tower on the far side of Earth's moon. Each of these missions exhibits different potential hazards. Based on their previous experiments with different types of glove materials, students develop and test glove designs that will protect astronauts from mission-specific hazards, while still

  9. Relay Protection and Automation Systems Based on Programmable Logic Integrated Circuits

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lashin, A. V., E-mail: LashinAV@lhp.ru; Kozyrev, A. V.

    One of the most promising forms of developing the apparatus part of relay protection and automation devices is considered. The advantages of choosing programmable logic integrated circuits to obtain adaptive technological algorithms in power system protection and control systems are pointed out. The technical difficulties in the problems which today stand in the way of using relay protection and automation systems are indicated and a new technology for solving these problems is presented. Particular attention is devoted to the possibility of reconfiguring the logic of these devices, using programmable logic integrated circuits.

  10. A secure steganography for privacy protection in healthcare system.

    PubMed

    Liu, Jing; Tang, Guangming; Sun, Yifeng

    2013-04-01

    Private data in healthcare system require confidentiality protection while transmitting. Steganography is the art of concealing data into a cover media for conveying messages confidentially. In this paper, we propose a steganographic method which can provide private data in medical system with very secure protection. In our method, a cover image is first mapped into a 1D pixels sequence by Hilbert filling curve and then divided into non-overlapping embedding units with three consecutive pixels. We use adaptive pixel pair match (APPM) method to embed digits in the pixel value differences (PVD) of the three pixels and the base of embedded digits is dependent on the differences among the three pixels. By solving an optimization problem, minimal distortion of the pixel ternaries caused by data embedding can be obtained. The experimental results show our method is more suitable to privacy protection of healthcare system than prior steganographic works.

  11. Evaluation of Utah Transit Authority's Connection Protection system

    DOT National Transportation Integrated Search

    2004-05-12

    The Utah Transit Authority (UTA) implemented a Connection Protection (CP) system to improve the reliability of transfers from the higher frequency light rail TRAX trains to the lower frequency bus services. The CP system examines the status of TRAX t...

  12. Quench Detection and Protection for High Temperature Superconducting Transformers by Using the Active Power Method

    NASA Astrophysics Data System (ADS)

    Nanato, N.; Kobayashi, Y.

    AC high temperature superconducting (HTS) coils have been developed for transformers, motors and so on. Quench detection and protection system are essential for safety operations of the AC HTS facilities. The balance voltage method is universally used for the quench detection and protection, however especially for AC operations, the method has risks in terms of high voltage sparks. Because the method needs a voltage tap soldered to a midpoint of the coil winding and the AC HTS facilities generally operate at high voltages and therefore high voltage sparks may occur at the midpoint with no insulation. We have proposed the active power method for the quench detection and protection. The method requires no voltage tap on the midpoint of the coil winding and therefore it has in-built effectiveness for the AC HTS facilities. In this paper, we show that the method can detect the quench in an HTS transformer and moreover our proposed quench protection circuits which consist of thyristors are simple and useful for the AC HTS facilities.

  13. 78 FR 49479 - Updates to List of National System of Marine Protected Areas MPAs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-14

    ... System of Marine Protected Areas MPAs AGENCY: National Marine Protected Areas Center (MPA Center), Office... Administration (NOAA), Department of Commerce (DOC). ACTION: Notice of updates to the list of National System of Marine Protected Areas (MPAs). SUMMARY: The National System of Marine Protected Areas (MPAs) provides a...

  14. Development of a Communication System Compatible with Chemical Protective Clothing and Equipment.

    DTIC Science & Technology

    1986-06-23

    for the Chemical Protective Clothing Communication System are discussed in the operation manuals for the engineering prototypes of the trans- ceiver...Report Date DEVELOPMENT OF A COMMUNICATION SYSTEM COMPATIBLE June 1986 WITH CHEMICAL PROTECTIVE CLOTHING AND EQUIPMENT 6. Performing Organization Code 8...Abstract - ’The U. S. Coast Guard and NASA joined in a project to develop a cominications system to operate inside protective suits used in chemical spill

  15. A ceramic matrix composite thermal protection system for hypersonic vehicles

    NASA Technical Reports Server (NTRS)

    Riccitiello, Salvatore R.; Love, Wendell L.; Pitts, William C.

    1993-01-01

    The next generation of hypersonic vehicles (NASP, SSTO) that require reusable thermal protection systems will experience acreage surface temperatures in excess of 1100 C. More important, they will experience a more severe physical environment than the Space Shuttle due to non-pristine launching and landing conditions. As a result, maintenance, inspection, and replacement factors must be more thoroughly incorporated into the design of the TPS. To meet these requirements, an advanced thermal protection system was conceived, designated 'TOPHAT'. This system consists of a toughened outer ceramic matrix composite (CMC) attached to a rigid reusable surface insulator (RSI) which is directly bonded to the surface. The objective of this effort was to evaluate this concept in an aeroconvective environment, to determine the effect of impacts to the CMC material, and to compare the results with existing thermal protection systems.

  16. A Study of the Effects of Altitude on Thermal Ice Protection System Performance

    NASA Technical Reports Server (NTRS)

    Addy, Gene; Oleskiw, Myron; Broeren, Andy P.; Orchard, David

    2013-01-01

    Thermal ice protection systems use heat energy to prevent a dangerous buildup of ice on an aircraft. As aircraft become more efficient, less heat energy is available to operate a thermal ice protections system. This requires that thermal ice protection systems be designed to more exacting standards so as to more efficiently prevent a dangerous ice buildup without adversely affecting aircraft safety. While the effects of altitude have always beeing taked into account in the design of thermal ice protection systems, a better understanding of these effects is needed so as to enable more exact design, testing, and evaluation of these systems.

  17. 75 FR 52768 - National Protection and Programs Directorate; Agency Information Collection Activities: Office of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-27

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0071] National Protection and Programs Directorate; Agency Information Collection Activities: Office of Infrastructure Protection; Chemical Security.... SUMMARY: The Department of Homeland Security, National Protection and Programs Directorate, Office of...

  18. Design of a Thermal and Micrometeorite Protection System for an Unmanned Lunar Cargo Lander

    NASA Technical Reports Server (NTRS)

    Hernandez, Carlos A.; Sunder, Sankar; Vestgaard, Baard

    1989-01-01

    The first vehicles to land on the lunar surface during the establishment phase of a lunar base will be unmanned lunar cargo landers. These landers will need to be protected against the hostile lunar environment for six to twelve months until the next manned mission arrives. The lunar environment is characterized by large temperature changes and periodic micrometeorite impacts. An automatically deployable and reconfigurable thermal and micrometeorite protection system was designed for an unmanned lunar cargo lander. The protection system is a lightweight multilayered material consisting of alternating layers of thermal and micrometeorite protection material. The protection system is packaged and stored above the lander common module. After landing, the system is deployed to cover the lander using a system of inflatable struts that are inflated using residual fuel (liquid oxygen) from the fuel tanks. Once the lander is unloaded and the protection system is no longer needed, the protection system is reconfigured as a regolith support blanket for the purpose of burying and protecting the common module, or as a lunar surface garage that can be used to sort and store lunar surface vehicles and equipment. A model showing deployment and reconfiguration of the protection system was also constructed.

  19. The IAEA’s activities on radiation protection in interventional cardiology

    PubMed Central

    Rehani, MM

    2007-01-01

    The International Atomic Energy Agency (IAEA) under its mandate of developing and applying standards of radiation safety has initiated a number of activities in recent years on radiation protection in interventional cardiology. These activities are implemented through four mechanisms, namely training, providing information through the website, research projects and assistance to Member States through Technical Cooperation (TC) projects. Major international initiatives have been taken in the area of training where more than half a dozen regional training courses have been conducted for cardiologists from over 50 countries. Additionally four national training events for over 300 medical and paramedical staff members involved in interventional procedures were held. The training material is freely available on CD from the IAEA. The newly established website provides information on radiation protection issues [1]. Two coordinated research projects have just been completed where peak skin doses to patients undergoing high dose interventional procedures were studied and factors to manage patient doses were identified. The technical cooperation projects involving protection in cardiac interventional procedures have 30 countries as participants. PMID:21614275

  20. Fragrant unsaturated aldehydes elicit activation of the Keap1/Nrf2 system leading to the upregulation of thioredoxin expression and protection against oxidative stress.

    PubMed

    Masutani, Hiroshi; Otsuki, Ryoko; Yamaguchi, Yoshimi; Takenaka, Masahiro; Kanoh, Nobue; Takatera, Koji; Kunimoto, Yuji; Yodoi, Junji

    2009-05-01

    Thioredoxin, a key molecule in redox regulation, and many redox enzymes are regulated through the antioxidant responsive element (ARE). To search for antioxidative constituents, we screened extracts from vegetables and found that the extracts of Perilla frutescens and Artemisia princeps have potent thioredoxin-inducing activities. By activity-guided purification of Perilla frutescens extracts, we identified perillaldehyde as a novel thioredoxin inducer. Fragrant unsaturated aldehydes, such as trans-cinnamaldehyde, safranal, 2,4-octadienal, citral, trans-2, cis-6-nonadienal, and trans-2-hexenal showed the ability to activate ARE. Perillaldehyde-induced activation through the ARE was suppressed by the overexpression of wild-type Keap1, whereas sulforaphane-induced activation seemed to be partially suppressed. Mutant Keap1 (R272A/K287A or C273A/C288A) did not suppress this activation. Pretreatment with perillaldehyde reduced the H(2)O(2)-induced cytotoxicity. Thus, we show that fragrant unsaturated aldehydes from edible plants are novel thioredoxin inducers and ARE activators and may be beneficial for protection against oxidative stress-induced cellular damage. These results also suggest that perillaldehyde activates the Nrf2-Keap1 system and that the lysine and arginine residues juxtaposed to the critical cysteine residues of Keap1 are required for signal sensing.

  1. Implementation of Pilot Protection System for Large Scale Distribution System like The Future Renewable Electric Energy Distribution Management Project

    NASA Astrophysics Data System (ADS)

    Iigaya, Kiyohito

    A robust, fast and accurate protection system based on pilot protection concept was developed previously and a few alterations in that algorithm were made to make it faster and more reliable and then was applied to smart distribution grids to verify the results for it. The new 10 sample window method was adapted into the pilot protection program and its performance for the test bed system operation was tabulated. Following that the system comparison between the hardware results for the same algorithm and the simulation results were compared. The development of the dual slope percentage differential method, its comparison with the 10 sample average window pilot protection system and the effects of CT saturation on the pilot protection system are also shown in this thesis. The implementation of the 10 sample average window pilot protection system is done to multiple distribution grids like Green Hub v4.3, IEEE 34, LSSS loop and modified LSSS loop. Case studies of these multi-terminal model are presented, and the results are also shown in this thesis. The result obtained shows that the new algorithm for the previously proposed protection system successfully identifies fault on the test bed and the results for both hardware and software simulations match and the response time is approximately less than quarter of a cycle which is fast as compared to the present commercial protection system and satisfies the FREEDM system requirement.

  2. Prevention and the Child Protection System

    ERIC Educational Resources Information Center

    Waldfogel, Jane

    2009-01-01

    The nation's child protection system (CPS) has historically focused on preventing maltreatment in high-risk families, whose children have already been maltreated. But, as Jane Waldfogel explains, it has also begun developing prevention procedures for children at lower risk--those who are referred to CPS but whose cases do not meet the criteria for…

  3. Alternative High Performance Polymers for Ablative Thermal Protection Systems

    NASA Technical Reports Server (NTRS)

    Boghozian, Tane; Stackpoole, Mairead; Gonzales, Greg

    2015-01-01

    Ablative thermal protection systems are commonly used as protection from the intense heat during re-entry of a space vehicle and have been used successfully on many missions including Stardust and Mars Science Laboratory both of which used PICA - a phenolic based ablator. Historically, phenolic resin has served as the ablative polymer for many TPS systems. However, it has limitations in both processing and properties such as char yield, glass transition temperature and char stability. Therefore alternative high performance polymers are being considered including cyanate ester resin, polyimide, and polybenzoxazine. Thermal and mechanical properties of these resin systems were characterized and compared with phenolic resin.

  4. Extravehicular Activity and Planetary Protection

    NASA Technical Reports Server (NTRS)

    Buffington, J. A.; Mary, N. A.

    2015-01-01

    The first human mission to Mars will be the farthest distance that humans have traveled from Earth and the first human boots on Martian soil in the Exploration EVA Suit. The primary functions of the Exploration EVA Suit are to provide a habitable, anthropometric, pressurized environment for up to eight hours that allows crewmembers to perform autonomous and robotically assisted extravehicular exploration, science/research, construction, servicing, and repair operations on the exterior of the vehicle, in hazardous external conditions of the Mars local environment. The Exploration EVA Suit has the capability to structurally interface with exploration vehicles via next generation ingress/egress systems. Operational concepts and requirements are dependent on the mission profile, surface assets, and the Mars environment. This paper will discuss the effects and dependencies of the EVA system design with the local Mars environment and Planetary Protection. Of the three study areas listed for the workshop, EVA identifies most strongly with technology and operations for contamination control.

  5. Evaluation of the immunomodulatory and DNA protective activities of the shoots of Cynodon dactylon.

    PubMed

    Mangathayaru, K; Umadevi, M; Reddy, C Umamaheswara

    2009-05-04

    Fresh juice of Cyanodon dactylon known as 'durva' grass is employed in India as a rejuvenator and for wound healing. To validate the traditional use of the herb through evaluation of DNA protective activity in vitro and immunomodulatory activity in vivo. Fresh juice of the grass was prepared as indicated for use in traditional medicine and standardized for solid content. Its total phenol content was estimated by Folin-Ciocalteau method. Freshly prepared juice was investigated for its effect on doxorubicin-induced DNA damage in vitro. Its immunomodulatory activity was tested on balb/c mice by the humoral antibody response which was determined by haemagglutination antibody titer and spleen cell assay. Fresh juice of Cyanodon dactylon of 1.46% (w/w) solid content had a phenolic content of 47+/-0.33 mg/kg GAE. At doses equivalent to 50, 100 and 200mg total solids/kg body weight the juice protected human DNA against doxorubicin-induced DNA damage as demonstrated in DNA spectral studies, where the ratio of absorbance of DNA at 260 and 280 nm in samples pretreated with the juice was 1.66, 1.53 and 1.63 respectively, while it was 1.37 for DNA treated with doxorubicin only. This indicates nucleic acid purity in the Cynodon dactylon treated samples. Oral administration of the juice at 250 and 500 mg/kg in balb/c mice increased humoral antibody response upon antigen challenge, as evidenced by a dose-dependent, statistically significant increase in antibody titer in the haemagglutination antibody assay and plaque forming cell assay. The present report demonstrated the DNA protective activity and immunomodulatory property of the fresh juice of Cynodon dactylon validating the traditional use of the herb as a 'rasayana' in ayurvedic system of medicine.

  6. HIF1α-dependent glycolysis promotes macrophage functional activities in protecting against bacterial and fungal infection.

    PubMed

    Li, Chunxiao; Wang, Yu; Li, Yan; Yu, Qing; Jin, Xi; Wang, Xiao; Jia, Anna; Hu, Ying; Han, Linian; Wang, Jian; Yang, Hui; Yan, Dapeng; Bi, Yujing; Liu, Guangwei

    2018-02-26

    Macrophages are important innate immune defense system cells in the fight against bacterial and fungal pathogenic infections. They exhibit significant plasticity, particularly with their ability to undergo functional differentiation. Additionally, HIF1α is critically involved in the functional differentiation of macrophages during inflammation. However, the role of macrophage HIF1α in protecting against different pathogenic infections remains unclear. In this study, we investigated and compared the roles of HIF1α in different macrophage functional effects of bacterial and fungal infections in vitro and in vivo. We found that bacterial and fungal infections produced similar effects on macrophage functional differentiation. HIF1α deficiency inhibited pro-inflammatory macrophage functional activities when cells were stimulated with LPS or curdlan in vitro or when mice were infected with L. monocytogenes or C. albicans in vivo, thus decreasing pro-inflammatory TNFα and IL-6 secretion associated with pathogenic microorganism survival. Alteration of glycolytic pathway activation was required for the functional differentiation of pro-inflammatory macrophages in protecting against bacterial and fungal infections. Thus, the HIF1α-dependent glycolytic pathway is essential for pro-inflammatory macrophage functional differentiation in protecting against bacterial and fungal infections.

  7. 49 CFR 195.428 - Overpressure safety devices and overfill protection systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... API Standard 2510 after October 2, 2000, must have an overfill protection system installed according to section 5.1.2 of API Standard 2510. Other aboveground breakout tanks with 600 gallons (2271 liters... have an overfill protection system installed according to API Recommended Practice 2350. However...

  8. 49 CFR 195.428 - Overpressure safety devices and overfill protection systems.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... API Standard 2510 after October 2, 2000, must have an overfill protection system installed according to section 5.1.2 of API Standard 2510. Other aboveground breakout tanks with 600 gallons (2271 liters... have an overfill protection system installed according to API Recommended Practice 2350. However...

  9. 49 CFR 195.428 - Overpressure safety devices and overfill protection systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... API Standard 2510 after October 2, 2000, must have an overfill protection system installed according to section 5.1.2 of API Standard 2510. Other aboveground breakout tanks with 600 gallons (2271 liters... have an overfill protection system installed according to API Recommended Practice 2350. However...

  10. 49 CFR 195.428 - Overpressure safety devices and overfill protection systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... API Standard 2510 after October 2, 2000, must have an overfill protection system installed according to section 5.1.2 of API Standard 2510. Other aboveground breakout tanks with 600 gallons (2271 liters... have an overfill protection system installed according to API Recommended Practice 2350. However...

  11. A ceramic matrix composite thermal protection system for hypersonic vehicles

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Riccitiello, S.R.; Love, W.L.; Pitts, W.C.

    1993-07-01

    The next generation of hypersonic vehicles (NASP, SSTO) that require reusable thermal protection systems will experience acreage surface temperatures in excess of 1100 C. More important, they will experience a more severe physical environment than the Space Shuttle due to non-pristine launching and landing conditions. As a result, maintenance, inspection, and replacement factors must be more thoroughly incorporated into the design of the TPS. To meet these requirements, an advanced thermal protection system was conceived, designated 'TOPHAT'. This system consists of a toughened outer ceramic matrix composite (CMC) attached to a rigid reusable surface insulator (RSI) which is directly bondedmore » to the surface. The objective of this effort was to evaluate this concept in an aeroconvective environment, to determine the effect of impacts to the CMC material, and to compare the results with existing thermal protection systems. 10 refs.« less

  12. Antioxidant activity and protective effect of Clitoria ternatea flower extract on testicular damage induced by ketoconazole in rats.

    PubMed

    Iamsaard, Sitthichai; Burawat, Jaturon; Kanla, Pipatpong; Arun, Supatcharee; Sukhorum, Wannisa; Sripanidkulchai, Bungorn; Uabundit, Nongnut; Wattathorn, Jintanaporn; Hipkaeo, Wiphawi; Fongmoon, Duriya; Kondo, Hisatake

    2014-06-01

    Ketoconazole (KET), an antifungal drug, has adverse effects on the male reproductive system. Pre-treatments with antioxidant plant against testicular damage induced by KET are required. The flowers of Clitoria ternatea (CT) are proven to have hepatoprotective potential. However, the protective effect on KET-induced testicular damage has not been reported. To investigate the protective effect of CT flower extracts with antioxidant activity on male reproductive parameters including sperm concentration, serum testosterone level, histopathology of the testis, and testicular tyrosine phosphorylation levels in rats induced with KET. The antioxidant activity of CT flower extracts was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. Male rats were treated with CT flower extracts (10, 50, or 100 mg/kg BW) or distilled water via a gastric tube for 28 d (preventive period: Days 1-21) and induced by KET (100 mg/kg BW) via intraperitoneal injection for 7 d (induction period: Days 22-28). After the experiment, all animals were examined for the weights of the testis, epididymis plus vas deferens and seminal vesicle, serum testosterone levels, sperm concentration, histological structures and diameter of testis, and testicular tyrosine phosphorylation levels by immunoblotting. The CT flower extracts had capabilities for DPPH scavenging and high reducing power. At 100 mg/kg BW, the extract had no toxic effects on the male reproductive system. Significantly, in CT+KET groups, CT flower extracts (50 and 100 mg/kg BW) alleviated the reduction of reproductive organ weight parameters, testosterone levels, and sperm concentration. In addition, CT flower extracts gave protection from testicular damage in KET-induced rats. Moreover, in the CT100+KET group, CT flower extracts significantly enhanced the expression of a testicular 50-kDa tyrosine phosphorylated protein compared with that of other groups. C. ternatea flower extracts

  13. Active corrosion protection performance of an epoxy coating applied on the mild steel modified with an eco-friendly sol-gel film impregnated with green corrosion inhibitor loaded nanocontainers

    NASA Astrophysics Data System (ADS)

    Izadi, M.; Shahrabi, T.; Ramezanzadeh, B.

    2018-05-01

    In this study the corrosion resistance, active protection, and cathodic disbonding performance of an epoxy coating were improved through surface modification of steel by a hybrid sol-gel system filled with green corrosion inhibitors loaded nanocontainer as intermediate layer on mild steel substrate. The green inhibitor loaded nanocontainers (GIN) were used to induce active inhibition performance in the protective coating system. The corrosion protection performance of the coated panels was investigated by electrochemical impedance spectroscopy (EIS), salt spray, and cathodic disbonding tests. It was observed that the corrosion inhibition performance of the coated mild steel panels was significantly improved by utilization of active multilayer coating system. The inhibitor release from nanocontainers at the epoxy-silane film/steel interface resulted in the anodic and cathodic reactions restriction, leading to the lower coating delamination from the substrate and corrosion products progress. Also, the active inhibition performance of the coating system was approved by electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM), and energy dispersive X-ray (EDS) analysis on the panels with artificial defects. The inhibitive agents were released to the scratch region and blocked the active sites on the metal surface.

  14. Strategies for protecting Western Burrowing Owls (Speotyto cunicularia hypugaea) from human activities

    Treesearch

    Lynne A. Trulio

    1997-01-01

    Practitioners have been using numerous methods to protect Burrowing Owls (Speotyto cunicularia hypugaea) affected by human activities. Primary approaches include protecting birds and burrows in place, allowing birds to relocate within their nesting territory, allowing birds to colonize new patches, moving birds within the geographic region and moving...

  15. MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity.

    PubMed

    Thomas, David M; Kuhn, Donald M

    2005-07-19

    Methamphetamine causes long-term toxicity to dopamine nerve endings of the striatum. Evidence is emerging that microglia can contribute to the neuronal damage associated with disease, injury, or inflammation, but their role in methamphetamine-induced neurotoxicity has received relatively little attention. Lipopolysaccharide (LPS) and the neurotoxic HIV Tat protein, which cause dopamine neuronal toxicity after direct infusion into brain, cause activation of cultured mouse microglial cells as evidenced by increased expression of intracellular cyclooxygenase-2 and elevated secretion of tumor necrosis factor-alpha. MK-801, a non-competitive NMDA receptor antagonist that is known to protect against methamphetamine neurotoxicity, prevents microglial activation by LPS and HIV Tat. Dextromethorphan, an antitussive agent with NMDA receptor blocking properties, also prevents microglial activation. In vivo, MK-801 and dextromethorphan reduce methamphetamine-induced activation of microglia in striatum and they protect dopamine nerve endings against drug-induced nerve terminal damage. The present results indicate that the ability of MK-801 and dextromethorphan to protect against methamphetamine neurotoxicity is related to their common property as blockers of microglial activation.

  16. Evaluation of Antioxidant and DNA Damage Protection Activity of the Hydroalcoholic Extract of Desmostachya bipinnata L. Stapf

    PubMed Central

    Bhimathati, Solomon Sunder Raj

    2014-01-01

    Desmostachya bipinnata Stapf (Poaceae/Gramineae) is an official drug of ayurvedic pharmacopoeia. Various parts of this plant were used extensively in traditional and folklore medicine to cure various human ailments. The present study was aimed to evaluate the antioxidant and DNA damage protection activity of hydroalcoholic extract of Desmostachya bipinnata both in vitro and in vivo, to provide scientific basis for traditional usage of this plant. The extract showed significant antioxidant activity in a dose-dependent manner with an IC50 value of 264.18 ± 3.47 μg/mL in H2O2 scavenging assay and prevented the oxidative damage to DNA in presence of DNA damaging agent (Fenton's reagent) at a concentration of 50 μg/mL. Also, the presence of extract protected yeast cells in a dose-dependent manner against DNA damaging agent (Hydroxyurea) in spot assay. Moreover, the presence of extract exhibited significant antioxidant activity in vivo by protecting yeast cells against oxidative stressing agent (H2O2). Altogether, the results of current study revealed that Desmostachya bipinnata is a potential source of antioxidants and lends pharmacological credence to the ethnomedical use of this plant in traditional system of medicine, justifying its therapeutic application for free-radical-induced diseases. PMID:24574873

  17. Evaluation of antioxidant and DNA damage protection activity of the hydroalcoholic extract of Desmostachya bipinnata L. Stapf.

    PubMed

    Golla, Upendarrao; Bhimathati, Solomon Sunder Raj

    2014-01-01

    Desmostachya bipinnata Stapf (Poaceae/Gramineae) is an official drug of ayurvedic pharmacopoeia. Various parts of this plant were used extensively in traditional and folklore medicine to cure various human ailments. The present study was aimed to evaluate the antioxidant and DNA damage protection activity of hydroalcoholic extract of Desmostachya bipinnata both in vitro and in vivo, to provide scientific basis for traditional usage of this plant. The extract showed significant antioxidant activity in a dose-dependent manner with an IC50 value of 264.18±3.47  μg/mL in H2O2 scavenging assay and prevented the oxidative damage to DNA in presence of DNA damaging agent (Fenton's reagent) at a concentration of 50  μg/mL. Also, the presence of extract protected yeast cells in a dose-dependent manner against DNA damaging agent (Hydroxyurea) in spot assay. Moreover, the presence of extract exhibited significant antioxidant activity in vivo by protecting yeast cells against oxidative stressing agent (H2O2). Altogether, the results of current study revealed that Desmostachya bipinnata is a potential source of antioxidants and lends pharmacological credence to the ethnomedical use of this plant in traditional system of medicine, justifying its therapeutic application for free-radical-induced diseases.

  18. Improving radioactive waste management: an overview of the Environmental Protection Agency's low-activity waste effort.

    PubMed

    Schultheisz, Daniel J; Czyscinski, Kenneth S; Klinger, Adam D

    2006-11-01

    Radioactive waste disposal in the United States is marked by a fragmented regulatory system, with requirements that often focus on the origin or statutory definition of the waste, rather than the hazard of the material in question. It may be possible to enhance public protection by moving toward a system that provides disposal options appropriate for the hazard presented by the waste in question. This paper summarizes aspects of an approach focusing on the potential use, with appropriate conditions, of Resource Conservation and Recovery Act Subtitle-C hazardous waste landfills for disposal of "low-activity" wastes and public comments on the suggested approach.

  19. Pentadecapeptide BPC 157 interactions with adrenergic and dopaminergic systems in mucosal protection in stress.

    PubMed

    Sikirić, P; Mazul, B; Seiwerth, S; Grabarević, Z; Rucman, R; Petek, M; Jagić, V; Turković, B; Rotkvić, I; Mise, S; Zoricić, I; Jurina, L; Konjevoda, P; Hanzevacki, M; Gjurasin, M; Separović, J; Ljubanović, D; Artuković, B; Bratulić, M; Tisljar, M; Miklić, P; Sumajstorcić, J

    1997-03-01

    Since superior protection against different gastrointestinal and liver lesions and antiinflammatory and analgesic activities were noted for pentadecapeptide BPC (an essential fragment of an organoprotective gastric juice protein named BPC), the beneficial mechanism of BPC 157 and its likely interactions with other systems were studied. Hence its beneficial effects would be abolished by adrenal gland medullectomy, the influence of different agents affecting alpha, beta, and dopamine receptors on BPC 157 gastroprotection in 48 h restraint stress was further investigated. Animals were pretreated (1 hr before stress) with saline (controls) or BPC 157 (dissolved in saline) (10 microg or 10 ng/kg body wt intraperitoneally or intragastrically) applied either alone to establish basal conditions or, when manipulating the adrenergic or dopaminergic system, a simultaneous administration was carried out with various agents with specific effects on adrenergic or dopaminergic receptors [given in milligrams per kilogram intraperitoneally except for atenolol, which was given subcutaneously] phentolamine (10.0), prazosin (0.5), yohimbine (5.0), clonidine (0.1) (alpha-adrenergic domain), propranolol (1.0), atenolol (20.0) (beta-adrenergic domain), domperidone (5.0), and haloperidol (5.0) (peripheral/central dopamine system). Alternatively, agents stimulating adrenergic or dopaminergic systems--adrenaline (5.0) or bromocriptine (10.0)--were applied. A strong protection, noted following intragastric or intraperitoneal administration of BPC 157, was fully abolished by coadministration of phentolamine, clonidine, and haloperidol, and consistently not affected by prazosin, yohimbine, or domperidone. Atenolol abolished only intraperitoneal BPC 157 protection, whereas propranolol affected specifically intragastric BPC 157 protection. Interestingly, the severe course of lesion development obtained in basal conditions, unlike BPC 157 gastroprotection, was not influenced by the application of

  20. Coherence protection in coupled quantum systems

    NASA Astrophysics Data System (ADS)

    Cammack, H. M.; Kirton, P.; Stace, T. M.; Eastham, P. R.; Keeling, J.; Lovett, B. W.

    2018-02-01

    The interaction of a quantum system with its environment causes decoherence, setting a fundamental limit on its suitability for quantum information processing. However, we show that if the system consists of coupled parts with different internal energy scales then the interaction of one part with a thermal bath need not lead to loss of coherence from the other. Remarkably, we find that the protected part can remain coherent for longer when the coupling to the bath becomes stronger or the temperature is raised. Our theory will enable the design of decoherence-resistant hybrid quantum computers.

  1. Protective immune responses against West Nile virus are primed by distinct complement activation pathways.

    PubMed

    Mehlhop, Erin; Diamond, Michael S

    2006-05-15

    West Nile virus (WNV) causes a severe infection of the central nervous system in several vertebrate animals including humans. Prior studies have shown that complement plays a critical role in controlling WNV infection in complement (C) 3(-/-) and complement receptor 1/2(-/-) mice. Here, we dissect the contributions of the individual complement activation pathways to the protection from WNV disease. Genetic deficiencies in C1q, C4, factor B, or factor D all resulted in increased mortality in mice, suggesting that all activation pathways function together to limit WNV spread. In the absence of alternative pathway complement activation, WNV disseminated into the central nervous system at earlier times and was associated with reduced CD8+ T cell responses yet near normal anti-WNV antibody profiles. Animals lacking the classical and lectin pathways had deficits in both B and T cell responses to WNV. Finally, and somewhat surprisingly, C1q was required for productive infection in the spleen but not for development of adaptive immune responses after WNV infection. Our results suggest that individual pathways of complement activation control WNV infection by priming adaptive immune responses through distinct mechanisms.

  2. Space Shuttle Thermal Protection System Repair Flight Experiment Induced Contamination Impacts

    NASA Technical Reports Server (NTRS)

    Smith, Kendall A.; Soares, Carlos E.; Mikatarian, Ron; Schmidl, Danny; Campbell, Colin; Koontz, Steven; Engle, Michael; McCroskey, Doug; Garrett, Jeff

    2006-01-01

    NASA s activities to prepare for Flight LF1 (STS-114) included development of a method to repair the Thermal Protection System (TPS) of the Orbiter s leading edge should it be damaged during ascent by impacts from foam, ice, etc . Reinforced Carbon-Carbon (RCC) is used for the leading edge TPS. The repair material that was developed is named Non- Oxide Adhesive eXperimental (NOAX). NOAX is an uncured adhesive material that acts as an ablative repair material. NOAX completes curing during the Orbiter s descent. The Thermal Protection System (TPS) Detailed Test Objective 848 (DTO 848) performed on Flight LF1 (STS-114) characterized the working life, porosity void size in a micro-gravity environment, and the on-orbit performance of the repairs to pre-damaged samples. DTO 848 is also scheduled for Flight ULF1.1 (STS-121) for further characterization of NOAX on-orbit performance. Due to the high material outgassing rates of the NOAX material and concerns with contamination impacts to optically sensitive surfaces, ASTM E 1559 outgassing tests were performed to determine NOAX condensable outgassing rates as a function of time and temperature. Sensitive surfaces of concern include the Extravehicular Mobility Unit (EMU) visor, cameras, and other sensors in proximity to the experiment during the initial time after application. This paper discusses NOAX outgassing characteristics, how the amount of deposition on optically sensitive surfaces while the NOAX is being manipulated on the pre-damaged RCC samples was determined by analysis, and how flight rules were developed to protect those optically sensitive surfaces from excessive contamination where necessary.

  3. Acquisition Systems Protection Planning the Manhatten Project: A Case Study

    DTIC Science & Technology

    1994-06-03

    This study examines the counterintelligence and security programs of the Manhattan Project , the United States acquisition of the atomic bomb, using...assessment methodology and counterintelligence techniques and procedures. Acquisition systems, Program protection, Manhattan Project , Atomic bomb, Technology protection, Counterintelligence, Security.

  4. Overvoltage protection system for wireless power transfer systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chambon, Paul H.; Jones, Perry T.; Miller, John M.

    A wireless power transfer overvoltage protection system is provided. The system includes a resonant receiving circuit. The resonant receiving circuit includes an inductor, a resonant capacitor and a first switching device. The first switching device is connected the ends of the inductor. The first switching device has a first state in which the ends of the inductor are electrically coupled to each other through the first switching device, and a second state in which the inductor and resonant capacitor are capable of resonating. The system further includes a control module configured to control the first switching device to switching betweenmore » the first state and the second state when the resonant receiving circuit is charging a load and a preset condition is satisfied and otherwise, the first switching device is maintained in the first state.« less

  5. Thermal and aerothermal performance of a titanium multiwall thermal protection system

    NASA Technical Reports Server (NTRS)

    Avery, D. E.; Shideler, J. L.; Stuckey, R. N.

    1981-01-01

    A metallic thermal protection system (TPS) concept the multiwall designed for temperature and pressure at Shuttle body point 3140 where the maximum surface temperature is approximately 811 K was tested to evaluate thermal performance and structural integrity. A two tile model of titanium multiwall and a model consisting of a low temperature reusable surface insulation (LRSI) tiles were exposed to 25 simulated thermal and pressure Shuttle entry missions. The two systems performed the same, and neither system deteriorated during the tests. It is indicated that redesign of the multiwall tiles reduces tile thickness and/or weight. A nine tile model of titanium multiwal was tested for radiant heating and aerothermodynamics. Minor design changes that improve structural integrity without having a significant impact on the thermal protection ability of the titanium multiwall TPS are identified. The capability of a titanium multiwall thermal protection system to protect an aluminum surface during a Shuttle type entry trajectory at locations on the vehicle where the maximum surface temperature is below 811 K is demonstrated.

  6. GCD TechPort Data Sheets Thermal Protection System Materials (TPSM) Project

    NASA Technical Reports Server (NTRS)

    Chinnapongse, Ronald L.

    2014-01-01

    The Thermal Protection System Materials (TPSM) Project consists of three distinct project elements: the 3-Dimensional Multifunctional Ablative Thermal Protection System (3D MAT) project element; the Conformal Ablative Thermal Protection System (CA-TPS) project element; and the Heatshield for Extreme Entry Environment Technology (HEEET) project element. 3D MAT seeks to design, develop and deliver a game changing material solution based on 3-dimensional weaving and resin infusion approach for manufacturing a material that can function as a robust structure as well as a thermal protection system. CA-TPS seeks to develop and deliver a conformal ablative material designed to be efficient and capable of withstanding peak heat flux up to 500 W/ sq cm, peak pressure up to 0.4 atm, and shear up to 500 Pa. HEEET is developing a new ablative TPS that takes advantage of state-of-the-art 3D weaving technologies and traditional manufacturing processes to infuse woven preforms with a resin, machine them to shape, and assemble them as a tiled solution on the entry vehicle substructure or heatshield.

  7. Muscarinic Receptor Activation Protects Cells from Apoptotic Effects of DNA Damage, Oxidative Stress, and Mitochondrial Inhibition*

    PubMed Central

    De Sarno, Patrizia; Shestopal, Svetlana A.; King, Taj D.; Zmijewska, Anna; Song, Ling; Jope, Richard S.

    2006-01-01

    The impact of muscarinic receptor stimulation was examined on apoptotic signaling induced by DNA damage, oxidative stress, and mitochondrial impairment. Exposure of human neuroblastoma SH-SY5Y cells to the DNA-damaging agent camptothecin increased p53 levels, activated caspase-3, and caused cell death. Pretreatment with oxotremorine-M, a selective agonist of muscarinic receptors that are expressed endogenously in these cells, did not affect the accumulation of p53 but greatly attenuated caspase-3 activation and protected from cell death to nearly the same extent as treatment with a general caspase inhibitor. Treatment with 50–200 μm H2O2 caused the activation of caspase-3 beginning after 2–3 h, followed by eventual cell death. Oxotremorine-M pretreatment protected cells from H2O2-inducedcaspase-3 activation and death, and this was equivalent to protection afforded by a caspase inhibitor. Muscarinic receptor stimulation also protected cells from caspase-3 activation induced by exposure to rotenone, a mitochondrial complex 1 inhibitor, but no protection was evident from staurosporine-induced caspase-3 activation. The mechanism of protection afforded by muscarinic receptor activation from camptothecin-induced apoptotic signaling involved blockade of mitochondrial cytochrome c release associated with a bolstering of mitochondrial bcl-2 levels and blockade of the translocation of Bax to mitochondria. Likely the most proximal of these events to muscarinic receptor activation, mitochondrial Bax accumulation, also was attenuated by oxotremorine-M treatment after treatment with H2O2 or rotenone. These results demonstrate that stimulation of muscarinic receptors provides substantial protection from DNA damage, oxidative stress, and mitochondrial impairment, insults that may be encountered by neurons in development, aging, or neurodegenerative diseases. These findings suggest that neurotransmitter-induced signaling bolsters survival mechanisms, and inadequate

  8. Lightning Protection and Detection System

    NASA Technical Reports Server (NTRS)

    Mielnik, John J. (Inventor); Woodard, Marie (Inventor); Smith, Laura J. (Inventor); Wang, Chuantong (Inventor); Koppen, Sandra V. (Inventor); Dudley, Kenneth L. (Inventor); Szatkowski, George N. (Inventor); Nguyen, Truong X. (Inventor); Ely, Jay J. (Inventor)

    2017-01-01

    A lightning protection and detection system includes a non-conductive substrate material of an apparatus; a sensor formed of a conductive material and deposited on the non-conductive substrate material of the apparatus. The sensor includes a conductive trace formed in a continuous spiral winding starting at a first end at a center region of the sensor and ending at a second end at an outer corner region of the sensor, the first and second ends being open and unconnected. An electrical measurement system is in communication with the sensor and receives a resonant response from the sensor, to perform detection, in real-time, of lightning strike occurrences and damage therefrom to the sensor and the non-conductive substrate material.

  9. Game theoretic analysis of physical protection system design

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Canion, B.; Schneider, E.; Bickel, E.

    The physical protection system (PPS) of a fictional small modular reactor (SMR) facility have been modeled as a platform for a game theoretic approach to security decision analysis. To demonstrate the game theoretic approach, a rational adversary with complete knowledge of the facility has been modeled attempting a sabotage attack. The adversary adjusts his decisions in response to investments made by the defender to enhance the security measures. This can lead to a conservative physical protection system design. Since defender upgrades were limited by a budget, cost benefit analysis may be conducted upon security upgrades. One approach to cost benefitmore » analysis is the efficient frontier, which depicts the reduction in expected consequence per incremental increase in the security budget.« less

  10. 46 CFR 58.25-55 - Overcurrent protection for steering-gear systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... overcurrent protection except short-circuit protection that is instantaneous and rated at 400% to 500% of— (1... for steering-gear systems. (a) Each feeder circuit for steering must be protected by a circuit breaker... motor for an alternating-current motor. (b) No feeder circuit for steering may have any overcurrent...

  11. Personal health record systems and their security protection.

    PubMed

    Win, Khin Than; Susilo, Willy; Mu, Yi

    2006-08-01

    The objective of this study is to analyze the security protection of personal health record systems. To achieve this we have investigated different personal health record systems, their security functions, and security issues. We have noted that current security mechanisms are not adequate and we have proposed some security mechanisms to tackle these problems.

  12. Analytical Approaches for Identification and Representation of Critical Protection Systems in Transient Stability Studies

    NASA Astrophysics Data System (ADS)

    Hedman, Mojdeh Khorsand

    After a major disturbance, the power system response is highly dependent on protection schemes and system dynamics. Improving power systems situational awareness requires proper and simultaneous modeling of both protection schemes and dynamic characteristics in power systems analysis tools. Historical information and ex-post analysis of blackouts reaffirm the critical role of protective devices in cascading events, thereby confirming the necessity to represent protective functions in transient stability studies. This dissertation is aimed at studying the importance of representing protective relays in power system dynamic studies. Although modeling all of the protective relays within transient stability studies may result in a better estimation of system behavior, representing, updating, and maintaining the protection system data becomes an insurmountable task. Inappropriate or outdated representation of the relays may result in incorrect assessment of the system behavior. This dissertation presents a systematic method to determine essential relays to be modeled in transient stability studies. The desired approach should identify protective relays that are critical for various operating conditions and contingencies. The results of the transient stability studies confirm that modeling only the identified critical protective relays is sufficient to capture system behavior for various operating conditions and precludes the need to model all of the protective relays. Moreover, this dissertation proposes a method that can be implemented to determine the appropriate location of out-of-step blocking relays. During unstable power swings, a generator or group of generators may accelerate or decelerate leading to voltage depression at the electrical center along with generator tripping. This voltage depression may cause protective relay mis-operation and unintentional separation of the system. In order to avoid unintentional islanding, the potentially mis-operating relays

  13. 20 CFR 1002.18 - What status or activity is protected from employer discrimination by USERRA?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What status or activity is protected from employer discrimination by USERRA? 1002.18 Section 1002.18 Employees' Benefits OFFICE OF THE ASSISTANT... from Employer Discrimination and Retaliation § 1002.18 What status or activity is protected from...

  14. Reusable thermal protection system development: A prospective

    NASA Technical Reports Server (NTRS)

    Goldstein, Howard

    1992-01-01

    The state of the art in passive reusable thermal protection system materials is described. Development of the Space Shuttle Orbiter, which was the first reusable vehicle, is discussed. The thermal protection materials and given concepts and some of the shuttle development and manufacturing problems are described. Evolution of a family of grid and flexible ceramic external insulation materials from the initial shuttle concept in the early 1970's to the present time is described. The important properties and their evolution are documented. Application of these materials to vehicles currently being developed and plans for research to meet the space programs future needs are summarized.

  15. Toward a Model-Based Approach to Flight System Fault Protection

    NASA Technical Reports Server (NTRS)

    Day, John; Murray, Alex; Meakin, Peter

    2012-01-01

    Fault Protection (FP) is a distinct and separate systems engineering sub-discipline that is concerned with the off-nominal behavior of a system. Flight system fault protection is an important part of the overall flight system systems engineering effort, with its own products and processes. As with other aspects of systems engineering, the FP domain is highly amenable to expression and management in models. However, while there are standards and guidelines for performing FP related analyses, there are not standards or guidelines for formally relating the FP analyses to each other or to the system hardware and software design. As a result, the material generated for these analyses are effectively creating separate models that are only loosely-related to the system being designed. Development of approaches that enable modeling of FP concerns in the same model as the system hardware and software design enables establishment of formal relationships that has great potential for improving the efficiency, correctness, and verification of the implementation of flight system FP. This paper begins with an overview of the FP domain, and then continues with a presentation of a SysML/UML model of the FP domain and the particular analyses that it contains, by way of showing a potential model-based approach to flight system fault protection, and an exposition of the use of the FP models in FSW engineering. The analyses are small examples, inspired by current real-project examples of FP analyses.

  16. Orbiter thermal protection system

    NASA Technical Reports Server (NTRS)

    Dotts, R. L.; Curry, D. M.; Tillian, D. J.

    1985-01-01

    The major material and design challenges associated with the orbiter thermal protection system (TPS), the various TPS materials that are used, the different design approaches associated with each of the materials, and the performance during the flight test program are described. The first five flights of the Orbiter Columbia and the initial flight of the Orbiter Challenger provided the data necessary to verify the TPS thermal performance, structural integrity, and reusability. The flight performance characteristics of each TPS material are discussed, based on postflight inspections and postflight interpretation of the flight instrumentation data. Flights to date indicate that the thermal and structural design requirements for the orbiter TPS are met and that the overall performance is outstanding.

  17. Final evaluation plan : Utah Transit Authority Connection Protection system

    DOT National Transportation Integrated Search

    2003-08-27

    Utah Transit Authority (UTA) implemented a Connection Protection system (CP) to improve the reliability of transfers from the higher frequency light rail trains, TRAX, to the lower frequency bus services. The CP system examines the status of TRAX tra...

  18. Traceability of radiation protection instruments

    NASA Astrophysics Data System (ADS)

    Hino, Y.; Kurosawa, T.

    2007-08-01

    Radiation protection instruments are used in daily measurement of dose and activities in workplaces and environments for safety management. The requirements for calibration certificates with traceability are increasing for these instruments to ensure the consistency and reliabilities of the measurement results. The present traceability scheme of radiation protection instruments for dose and activity measurements is described with related IEC/ISO requirements. Some examples of desirable future calibration systems with recent new technologies are also discussed to establish the traceability with reasonable costs and reliabilities.

  19. 14 CFR 25.1316 - System lightning protection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... systems to perform these functions are not adversely affected when the airplane is exposed to lightning... these functions can be recovered in a timely manner after the airplane is exposed to lightning. (c) Compliance with the lightning protection criteria prescribed in paragraphs (a) and (b) of this section must...

  20. Intracellular ROS protection efficiency and free radical-scavenging activity of quercetin and quercetin-encapsulated liposomes.

    PubMed

    Rezaei-Sadabady, Rogaie; Eidi, Akram; Zarghami, Nosratollah; Barzegar, Abolfazl

    2016-01-01

    Quercetin (3,5,7,3',4'-pentahydroxyflavone) is a natural bio-flavonoid originating from fruits, vegetables, seeds, berries, and tea. The antioxidant activity of quercetin and its protective effects against cardiovascular disorders, anti-cancer, anti-inflammatory, and anti-viral activities have been extensively documented; however, the clinical request of quercetin in cancer treatment is significantly limited due to its very poor delivery features. In order to increase the hydrophilicity and drug delivery capability, we encapsulated quercetin into liposomes. Our data indicated that liposomal quercetin can significantly improve the solubility and bioavailability of quercetin and can be used as an effective antioxidant for ROS protection within the polar cytoplasm, and the nano-sized quercetin encapsulated by liposomes enhanced the cellular uptake (cancer cell human MCF_7). Quercetin has many pharmaceutical applications, many of which arise from its potent antioxidant properties. The present research examined the antioxidant activities of quercetin in polar solvents by a comparative study using reduction of ferric iron in aqueous medium, intracellular ROS/toxicity assays, and reducing DPPH assays. Cell viability and ROS assays demonstrated that quercetin was able to penetrate into the polar medium inside the cells and to protect them against the highly toxic and deadly belongings of cumene hydroperoxide. The purpose of this study was to determine whether a liposomal formulation of quercetin can suggestively improve its solubility and bioavailability and can be a possible request in the treatment of tumor. The authors encapsulated quercetin in a liposomal delivery system. They studied the in vitro effects of this compound on proliferation using human MCF-7 carcinoma cells. The activity of liposomal quercetin was equal to or better than that of free quercetin at equimolar concentrations. Our data indicated that liposomal quercetin can significantly improve the

  1. Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gan Nanqin; Mi Lixin; Sun Xiaoyun

    2010-09-01

    Microcystins (MCs), a cyclic heptapeptide hepatotoxins, are mainly produced by the bloom-forming cyanobacerium Microcystis, which has become an environmental hazard worldwide. Long term consumption of MC-contaminated water may induce liver damage, liver cancer, and even human death. Therefore, in addition to removal of MCs in drinking water, novel strategies that prevent health damages are urgently needed. Sulforaphane (SFN), a natural-occurring isothiocyanate from cruciferous vegetables, has been reported to reduce and eliminate toxicities from xenobiotics and carcinogens. The purpose of the present study was to provide mechanistic insights into the SFN-induced antioxidative defense system against MC-LR-induced cytotoxicity. We performed cell viabilitymore » assays, including MTS assay, colony formation assay and apoptotic cell sorting, to study MC-LR-induced cellular damage and the protective effects by SFN. The results showed that SFN protected MC-LR-induced damages at a nontoxic and physiological relevant dose in HepG2, BRL-3A and NIH 3 T3 cells. The protection was Nrf2-mediated as evident by transactivation of Nrf2 and activation of its downstream genes, including NQO1 and HO-1, and elevated intracellular GSH level. Results of our studies indicate that pretreatment of cells with 10 {mu}M SFN for 12 h significantly protected cells from MC-LR-induced damage. SFN-induced protective response was mediated through Nrf2 pathway.« less

  2. Extravehicular Activity (EVA) 101: Constellation EVA Systems

    NASA Technical Reports Server (NTRS)

    Jordan, Nicole C.

    2007-01-01

    A viewgraph presentation on Extravehicular Activity (EVA) Systems is shown. The topics include: 1) Why do we need space suits? 2) Protection From the Environment; 3) Primary Life Support System (PLSS); 4) Thermal Control; 5) Communications; 6) Helmet and Extravehicular Visor Assy; 7) Hard Upper Torso (HUT) and Arm Assy; 8) Display and Controls Module (DCM); 9) Gloves; 10) Lower Torso Assembly (LTA); 11) What Size Do You Need?; 12) Boot and Sizing Insert; 13) Boot Heel Clip and Foot Restraint; 14) Advanced and Crew Escape Suit; 15) Nominal & Off-Nominal Landing; 16) Gemini Program (mid-1960s); 17) Apollo EVA on Service Module; 18) A Bold Vision for Space Exploration, Authorized by Congress; 19) EVA System Missions; 20) Configurations; 21) Reduced Gravity Program; and 22) Other Opportunities.

  3. Interim report : a non-overlay cathodic protection system.

    DOT National Transportation Integrated Search

    1983-01-01

    This interim report describes Virginia's experience in installing its first cathodic protection system for a bridge deck. The installation was completed with practically no problems. Very minor problems have been encountered with the rectifier/contro...

  4. Thermal protection system (TPS) monitoring using acoustic emission

    NASA Astrophysics Data System (ADS)

    Hurley, D. A.; Huston, D. R.; Fletcher, D. G.; Owens, W. P.

    2011-04-01

    This project investigates acoustic emission (AE) as a tool for monitoring the degradation of thermal protection systems (TPS). The AE sensors are part of an array of instrumentation on an inductively coupled plasma (ICP) torch designed for testing advanced thermal protection aerospace materials used for hypervelocity vehicles. AE are generated by stresses within the material, propagate as elastic stress waves, and can be detected with sensitive instrumentation. Graphite (POCO DFP-2) is used to study gas-surface interaction during degradation of thermal protection materials. The plasma is produced by a RF magnetic field driven by a 30kW power supply at 3.5 MHz, which creates a noisy environment with large spikes when powered on or off. AE are waveguided from source to sensor by a liquid-cooled copper probe used to position the graphite sample in the plasma stream. Preliminary testing was used to set filters and thresholds on the AE detection system (Physical Acoustics PCI-2) to minimize the impact of considerable operating noise. Testing results show good correlation between AE data and testing environment, which dictates the physics and chemistry of the thermal breakdown of the sample. Current efforts for the project are expanding the dataset and developing statistical analysis tools. This study shows the potential of AE as a powerful tool for analysis of thermal protection material thermal degradations with the unique capability of real-time, in-situ monitoring.

  5. MMOD Protection and Degradation Effects for Thermal Control Systems

    NASA Technical Reports Server (NTRS)

    Christiansen, Eric

    2014-01-01

    Micrometeoroid and orbital debris (MMOD) environment overview Hypervelocity impact effects & MMOD shielding MMOD risk assessment process Requirements & protection techniques - ISS - Shuttle - Orion/Commercial Crew Vehicles MMOD effects on spacecraft systems & improving MMOD protection - Radiators Coatings - Thermal protection system (TPS) for atmospheric entry vehicles Coatings - Windows - Solar arrays - Solar array masts - EVA Handrails - Thermal Blankets Orbital Debris provided by JSC & is the predominate threat in low Earth orbit - ORDEM 3.0 is latest model (released December 2013) - http://orbitaldebris.jsc.nasa.gov/ - Man-made objects in orbit about Earth impacting up to 16 km/s average 9-10 km/s for ISS orbit - High-density debris (steel) is major issue Meteoroid model provided by MSFC - MEM-R2 is latest release - http://www.nasa.gov/offices/meo/home/index.html - Natural particles in orbit about sun Mg-silicates, Ni-Fe, others - Meteoroid environment (MEM): 11-72 km/s Average 22-23 km/s.

  6. Protection of Hardware: Powering Systems (Power Converter, Normal Conducting, and Superconducting Magnets)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pfeffer, H.; Flora, B.; Wolff, D.

    2016-01-01

    Along with the protection of magnets and power converters, we have added a section on personnel protection because this is our highest priority in the design and operation of power systems. Thus, our topics are the protection of people, power converters, and magnet loads (protected from the powering equipment), including normal conducting magnets and superconducting magnets.

  7. [Child protection system: Knowledge and role of the general practitioners in Ille-et-Vilaine].

    PubMed

    Balençon, M; Arrieta, A; You, C A; Brun, J-F; Federico-Desgranges, M; Roussey, M

    2016-01-01

    On 5 March 2007 the law concerning the child protection system was reformed. Since this date, child protection services are responsible for child abuse and neglect. Child protection services are now attempting to determine the rightful place for parents. Asking for child protection is now easier for the general practitioner (GP), who can submit a "preoccupying information (PI)" form. The aim of this study was to review GPs' knowledge on this issue 6 years after the passage of this new law. Prospective postal investigation between 04/01/2013 and 06/01/2013. A total of 298 (113 women) of the 899 GPs of the Ille-et-Vilaine area in Brittany answered a few questions about their activity and their knowledge on child abuse and neglect. The sample's mean age, sex, and practice was representative of the GPs in this area. Only 25.5% of the GPs had any knowledge of this new law. The term "preoccupying information" was unfamiliar to 70.1% of the GPs and what to do with the PI was unknown to 77.2%. The GPs did not know which type of letter to send nor where to send it between legal child protection and social protection services. Only 5% of the GPs had child protection training on PI. The main problem informing the child protection services was the lack of training. Consequently, 91.9% of the GPs would like training. The GPs in the Ille-et-Vilaine area in Brittany are unfamiliar with the child protection updates and need special training. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  8. The protective activity of Conyza blinii saponin against acute gastric ulcer induced by ethanol.

    PubMed

    Ma, Long; Liu, Jiangguang

    2014-12-02

    Conyza blinii H.Lév., is a type of natural plant. Its dried overground section is used to treat infections and inflammations in traditional Chinese medicine. Triterpenoidal saponins have a wide range of bioactivities, for instance, anti-cancer, anti-virus and anti-anaphylaxis. Conyza blinii saponin (CBS), mainly composed of triterpenoidal saponins, is the total saponin of Conyza blinii H.Lév. It has been reported that CBS also has gastric mucous membrane protection activity. This study aims to test CBS׳s protective activity of gastric׳s mucous membrane against ethanol. This investigation may lead to the development of novel drug from natural products as anti-ulcer agent, or as gastric mucous protective against chemical damage. CBS (Conyza blinii saponin) is the total saponin of Conyza blinii H.Lév., which was obtained as described previously. We tested the protective activity of CBS against ethanol-induced ulcer. Thirty six rats were grouped randomly as 'NORMAL', 'CONTROL', 'MODEL', 'LOW DOSE', 'MEDIUM DOSE' and 'HIGH DOSE'. The 'NORMAL' group were rats with no pathological model established within it. The 'CONTROL' group was administrated with colloidal bismuth subcitrate, while 'MODEL' group was not given any active agents apart from absolute ethanol in order to obtain gastric ulcer model. The three 'DOSE' groups were treated with different concentrations of CBS (5, 10, 20mg/mL) before administration followed by absolute ethanol. All rats were sacrificed after the experiment to acquire the gastric tissue. The ulcer index (UI), malondialdehyde (MDA) and superoxide dismutase (SOD) were measured to monitor the activity of CBS. Besides, the rat gastric tissue was made to paraffin section and stained using the Hematoxylin-Eosin (HE) method. The histopathology examination was carried out to examine CBS efficacy in terms of gastric mucous protection. We found that CBS had a profound protection activity against acute gastric ulcer induced by ethanol and this

  9. A modernized high-pressure heater protection system for nuclear and thermal power stations

    NASA Astrophysics Data System (ADS)

    Svyatkin, F. A.; Trifonov, N. N.; Ukhanova, M. G.; Tren'kin, V. B.; Koltunov, V. A.; Borovkov, A. I.; Klyavin, O. I.

    2013-09-01

    Experience gained from operation of high-pressure heaters and their protection systems serving to exclude ingress of water into the turbine is analyzed. A formula for determining the time for which the high-pressure heater shell steam space is filled when a rupture of tubes in it occurs is analyzed, and conclusions regarding the high-pressure heater design most advisable from this point of view are drawn. A typical structure of protection from increase of water level in the shell of high-pressure heaters used in domestically produced turbines for thermal and nuclear power stations is described, and examples illustrating this structure are given. Shortcomings of components used in the existing protection systems that may lead to an accident at the power station are considered. A modernized protection system intended to exclude the above-mentioned shortcomings was developed at the NPO Central Boiler-Turbine Institute and ZioMAR Engineering Company, and the design solutions used in this system are described. A mathematical model of the protection system's main elements (the admission and check valves) has been developed with participation of specialists from the St. Petersburg Polytechnic University, and a numerical investigation of these elements is carried out. The design version of surge tanks developed by specialists of the Central Boiler-Turbine Institute for excluding false operation of the high-pressure heater protection system is proposed.

  10. National understanding and acceptance of occupant protection systems

    DOT National Transportation Integrated Search

    1986-07-01

    Regulations requiring new cars to be equipped with automatic occupant protection systems unless states representing two-thirds of the population enact mandatory safety belt use regulation by 1989 necessitated a study to determine the public's knowled...

  11. AMP-activated protein kinase protects against necroptosis via regulation of Keap1-PGAM5 complex.

    PubMed

    Wang, Yi-Shu; Yu, Peng; Wang, Yong; Zhang, Jing; Hang, Wei; Yin, Zhi-Xian; Liu, Gang; Chen, Jianfeng; Werle, Kaitlin D; Quan, Cheng-Shi; Gao, Hang; Zeng, Qinghua; Cui, Rutao; Liang, Jiyong; Ding, Qiang; Li, Yu-Lin; Xu, Zhi-Xiang

    2018-05-15

    The AMP-activated protein kinase (AMPK) plays critical roles in growth regulation and metabolism reprogramming. AMPK activation protects cells against apoptosis from injury in different cell and animal models. However, its function in necroptosis remains largely unclear. In the current study, we demonstrated that AMPK was activated upon necroptosis induction and protected mouse embryonic fibroblasts (MEFs) and cardiomyocytes from N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and reactive oxygen species (ROS) induced necroptosis. Activation of AMPK with chemicals A-769662, 2-deoxyglucose (2-DG), and metformin or constitutively active (CA) AMPK markedly decreased necroptosis and cytotoxicity induced by MNNG. In contrast, AMPK inhibitor compound C, dominant negative (DN) AMPK, as well as AMPK shRNAs increased necroptosis and cytotoxicity induced by MNNG. We further showed that AMPK physically associated with a protein complex containing PGAM5 and Keap1 whereby facilitating Keap1-mediated PGAM5 ubiquitination upon necroptosis induction. The AMPK agonist metformin ameliorated myocardial ischemia and reperfusion (IR) injury and reduced necroptosis through down-regulating the expression of PGAM5 in the Langendorff-perfused rat hearts. Activation of AMPK protects against necroptosis via promoting Keap1-mediated PGAM5 degradation. Metformin may act as a valuable agent for the protection of myocardial ischemia and reperfusion injury by activating AMPK and reducing necroptosis. Copyright © 2018. Published by Elsevier B.V.

  12. Protective activity of hamamelitannin on cell damage induced by superoxide anion radicals in murine dermal fibroblasts.

    PubMed

    Masaki, H; Atsumi, T; Sakurai, H

    1995-01-01

    Previously we demonstrated that hamamelitannin (2',5-di-O-galloyl hamamelose) in Hamamelis virginiana L. exhibits potent superoxide-anion scavenging activity. We then examined the physiological and pharmacological activities of hamamelitannin as well as its functional homologues, gallic acid and syringic acid. The following results were obtained: (1) Hamamelitannin has a higher protective activity against cell damages induced by superoxide anions than gallic acid which is the functional moiety of hamamelitannin. The protective activity of hamamelitannin on murine fibroblast-damage induced by superoxide anions was found at a minimum concentration of 50 microM, while the corresponding figure for gallic acid was 100 microM. (2) Pre-treatment of fibroblasts with hamamelitannin enhances cell survival. (3) The superoxide-anion scavenging activity of the compound in terms of its IC50 value (50% inhibition concentration of superoxide anion radicals generated) was evaluated by ESR spin-trapping. Both hamamelitannin (IC50 = 1.31 +/- 0.06 microM) and gallic acid (IC50 = 1.01 +/- 0.03 microM) exhibited high superoxide-anion scavenging activity followed by syringic acid (IC50 = 13.90 +/- 2.38 microM). (4) When hamamelitannin was treated with superoxide anions generated by a KO2-crown ether system, HPLC analysis showed the disappearance of hamamelitannin and the concomitant formation of hamamelitannin-derived radicals (g = 2.005, delta H1 = 2.16 G, delta H2 = 4.69 G) was detected by ESR spectrometry.(ABSTRACT TRUNCATED AT 250 WORDS)

  13. Trade Study of System Level Ranked Radiation Protection Concepts for Deep Space Exploration

    NASA Technical Reports Server (NTRS)

    Cerro, Jeffrey A

    2013-01-01

    A strategic focus area for NASA is to pursue the development of technologies which support exploration in space beyond the current inhabited region of low earth orbit. An unresolved issue for crewed deep space exploration involves limiting crew radiation exposure to below acceptable levels, considering both solar particle events and galactic cosmic ray contributions to dosage. Galactic cosmic ray mitigation is not addressed in this paper, but by addressing credible, easily implemented, and mass efficient solutions for the possibility of solar particle events, additional margin is provided that can be used for cosmic ray dose accumulation. As a result, NASA s Advanced Engineering Systems project office initiated this Radiation Storm Shelter design activity. This paper reports on the first year results of an expected 3 year Storm Shelter study effort which will mature concepts and operational scenarios that protect exploration astronauts from solar particle radiation events. Large trade space definition, candidate concept ranking, and a planned demonstration comprised the majority of FY12 activities. A system key performance parameter is minimization of the required increase in mass needed to provide a safe environment. Total system mass along with operational assessments and other defined protection system metrics provide the guiding metrics to proceed with concept developments. After a downselect to four primary methods, the concepts were analyzed for dosage severity and the amount of shielding mass necessary to bring dosage to acceptable values. Besides analytical assessments, subscale models of several concepts and one full scale concept demonstrator were created. FY12 work terminated with a plan to demonstrate test articles of two selected approaches. The process of arriving at these selections and their current envisioned implementation are presented in this paper.

  14. Survey of cathodic protection systems on Virginia bridges.

    DOT National Transportation Integrated Search

    2007-01-01

    The Virginia Department of Transportation uses cathodic protection (CP) systems on steel-reinforced concrete structures to extend the life of these structures. The purpose of this study was to identify, categorize, and evaluate the performance of the...

  15. An effective and practical fire-protection system. [for aircraft fuel storage and transport

    NASA Technical Reports Server (NTRS)

    Mansfield, J. A.; Riccitiello, S. R.; Fewell, L. L.

    1975-01-01

    A high-performance sandwich-type fire protection system comprising a steel outer sheath and insulation combined in various configurations is described. An inherent advantage of the sheath system over coatings is that it eliminates problems of weatherability, materials strength, adhesion, and chemical attack. An experimental comparison between the protection performance of state-of-the-art coatings and the sheath system is presented, with emphasis on the protection of certain types of steel tanks for fuel storage and transport. Sheath systems are thought to be more expensive than coatings in initial implementation, although they are less expensive per year for sufficiently long applications.

  16. A Protective Mechanism of Visible Red Light in Normal Human Dermal Fibroblasts: Enhancement of GADD45A-Mediated DNA Repair Activity.

    PubMed

    Kim, Yeo Jin; Kim, Hyoung-June; Kim, Hye Lim; Kim, Hyo Jeong; Kim, Hyun Soo; Lee, Tae Ryong; Shin, Dong Wook; Seo, Young Rok

    2017-02-01

    The phototherapeutic effects of visible red light on skin have been extensively investigated, but the underlying biological mechanisms remain poorly understood. We aimed to elucidate the protective mechanism of visible red light in terms of DNA repair of UV-induced oxidative damage in normal human dermal fibroblasts. The protective effect of visible red light on UV-induced DNA damage was identified by several assays in both two-dimensional and three-dimensional cell culture systems. With regard to the protective mechanism of visible red light, our data showed alterations in base excision repair mediated by growth arrest and DNA damage inducible, alpha (GADD45A). We also observed an enhancement of the physical activity of GADD45A and apurinic/apyrimidinic endonuclease 1 (APE1) by visible red light. Moreover, UV-induced DNA damages were diminished by visible red light in an APE1-dependent manner. On the basis of the decrease in GADD45A-APE1 interaction in the activating transcription factor-2 (ATF2)-knockdown system, we suggest a role for ATF2 modulation in GADD45A-mediated DNA repair upon visible red light exposure. Thus, the enhancement of GADD45A-mediated base excision repair modulated by ATF2 might be a potential protective mechanism of visible red light. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  17. Towards modelling flood protection investment as a coupled human and natural system

    NASA Astrophysics Data System (ADS)

    O'Connell, P. E.; O'Donnell, G.

    2013-06-01

    Due to a number of recent high profile flood events and the apparent threat from global warming, governments and their agencies are under pressure to make proactive investments to protect people living in floodplains. However, adopting a proactive approach as a universal strategy is not affordable. It has been argued that delaying expensive and essentially irreversible capital decisions could be a prudent strategy in situations with high future uncertainty. This paper firstly uses Monte Carlo simulation to explore the performance of proactive and reactive investment strategies using a rational cost-benefit approach in a natural system with varying levels of persistence/interannual variability in Annual Maximum Floods. It is found that, as persistence increases, there is a change in investment strategy optimality from proactive to reactive. This could have implications for investment strategies under the increasingly variable climate that is expected with global warming. As part of the emerging holistic approaches to flood risk management, there is increasing emphasis on stakeholder participation in determining where and when flood protection investments are made, and so flood risk management is becoming more people-centred. As a consequence, multiple actors are involved in the decision-making process, and the social sciences are assuming an increasingly important role in flood risk management. There is a need for modelling approaches which can couple the natural and human system elements. It is proposed that Coupled Human and Natural System (CHANS) modelling could play an important role in understanding the motivations, actions and influence of citizens and institutions and how these impact on the effective delivery of flood protection investment. A framework for using Agent Based Modelling of human activities leading to flood investments is outlined, and some of the challenges associated with implementation are discussed.

  18. Towards modelling flood protection investment as a coupled human and natural system

    NASA Astrophysics Data System (ADS)

    O'Connell, P. E.; O'Donnell, G.

    2014-01-01

    Due to a number of recent high-profile flood events and the apparent threat from global warming, governments and their agencies are under pressure to make proactive investments to protect people living in floodplains. However, adopting a proactive approach as a universal strategy is not affordable. It has been argued that delaying expensive and essentially irreversible capital decisions could be a prudent strategy in situations with high future uncertainty. This paper firstly uses Monte Carlo simulation to explore the performance of proactive and reactive investment strategies using a rational cost-benefit approach in a natural system with varying levels of persistence/interannual variability in annual maximum floods. It is found that, as persistence increases, there is a change in investment strategy optimality from proactive to reactive. This could have implications for investment strategies under the increasingly variable climate that is expected with global warming. As part of the emerging holistic approaches to flood risk management, there is increasing emphasis on stakeholder participation in determining where and when flood protection investments are made, and so flood risk management is becoming more people-centred. As a consequence, multiple actors are involved in the decision-making process, and the social sciences are assuming an increasingly important role in flood risk management. There is a need for modelling approaches which can couple the natural and human system elements. It is proposed that coupled human and natural system (CHANS) modelling could play an important role in understanding the motivations, actions and influence of citizens and institutions and how these impact on the effective delivery of flood protection investment. A framework for using agent-based modelling of human activities leading to flood investments is outlined, and some of the challenges associated with implementation are discussed.

  19. Advanced emergency braking controller design for pedestrian protection oriented automotive collision avoidance system.

    PubMed

    Lie, Guo; Zejian, Ren; Pingshu, Ge; Jing, Chang

    2014-01-01

    Automotive collision avoidance system, which aims to enhance the active safety of the vehicle, has become a hot research topic in recent years. However, most of the current systems ignore the active protection of pedestrian and other vulnerable groups in the transportation system. An advanced emergency braking control system is studied by taking into account the pedestrians and the vehicles. Three typical braking scenarios are defined and the safety situations are assessed by comparing the current distance between the host vehicle and the obstacle with the critical braking distance. To reflect the nonlinear time-varying characteristics and control effect of the longitudinal dynamics, the vehicle longitudinal dynamics model is established in CarSim. Then the braking controller with the structure of upper and lower layers is designed based on sliding mode control and the single neuron PID control when confronting deceleration or emergency braking conditions. Cosimulations utilizing CarSim and Simulink are finally carried out on a CarSim intelligent vehicle model to explore the effectiveness of the proposed controller. Results display that the designed controller has a good response in preventing colliding with the front vehicle or pedestrian.

  20. Advanced Emergency Braking Controller Design for Pedestrian Protection Oriented Automotive Collision Avoidance System

    PubMed Central

    Lie, Guo; Zejian, Ren; Pingshu, Ge; Jing, Chang

    2014-01-01

    Automotive collision avoidance system, which aims to enhance the active safety of the vehicle, has become a hot research topic in recent years. However, most of the current systems ignore the active protection of pedestrian and other vulnerable groups in the transportation system. An advanced emergency braking control system is studied by taking into account the pedestrians and the vehicles. Three typical braking scenarios are defined and the safety situations are assessed by comparing the current distance between the host vehicle and the obstacle with the critical braking distance. To reflect the nonlinear time-varying characteristics and control effect of the longitudinal dynamics, the vehicle longitudinal dynamics model is established in CarSim. Then the braking controller with the structure of upper and lower layers is designed based on sliding mode control and the single neuron PID control when confronting deceleration or emergency braking conditions. Cosimulations utilizing CarSim and Simulink are finally carried out on a CarSim intelligent vehicle model to explore the effectiveness of the proposed controller. Results display that the designed controller has a good response in preventing colliding with the front vehicle or pedestrian. PMID:25097870

  1. Lack of an Efficient Endoplasmic Reticulum-localized Recycling System Protects Peroxiredoxin IV from Hyperoxidation*

    PubMed Central

    Cao, Zhenbo; Subramaniam, Suraj; Bulleid, Neil J.

    2014-01-01

    Typical 2-Cys peroxiredoxins are required to remove hydrogen peroxide from several different cellular compartments. Their activity can be regulated by hyperoxidation and consequent inactivation of the active-site peroxidatic cysteine. Here we developed a simple assay to quantify the hyperoxidation of peroxiredoxins. Hyperoxidation of peroxiredoxins can only occur efficiently in the presence of a recycling system, usually involving thioredoxin and thioredoxin reductase. We demonstrate that there is a marked difference in the sensitivity of the endoplasmic reticulum-localized peroxiredoxin to hyperoxidation compared with either the cytosolic or mitochondrial enzymes. Each enzyme is equally sensitive to hyperoxidation in the presence of a robust recycling system. Our results demonstrate that peroxiredoxin IV recycling in the endoplasmic reticulum is much less efficient than in the cytosol or mitochondria, leading to the protection of peroxiredoxin IV from hyperoxidation. PMID:24403061

  2. Current transformer model with hysteresis for improving the protection response in electrical transmission systems

    NASA Astrophysics Data System (ADS)

    Matussek, Robert; Dzienis, Cezary; Blumschein, Jörg; Schulte, Horst

    2014-12-01

    In this paper, a generic enhanced protection current transformer (CT) model with saturation effects and transient behavior is presented. The model is used for the purpose of analysis and design of power system protection algorithms. Three major classes of protection CT have been modeled which all take into account the nonlinear inductance with remanence effects. The transient short-circuit currents in power systems are simulated under CT saturation condition. The response of a common power system protection algorithm with respect to robustness to nominal parameter variations and sensitivity against maloperation is demonstrated by simulation studies.

  3. Weapon and Sighting System Compatibility Assessment for Prototype Maxillofacial Protection Devices

    DTIC Science & Technology

    2013-03-01

    No Maxillofacial Protection, No Visor (figure 38) ...........................22 7.2 Sighting System Compatibility – Bradley Fighting Vehicle ( BFV ...23 Figure 39. FASTBAC, bracket only ( BFV ...23 Figure 40. FASTBAC bracket and maxillofacial protection ( BFV ). ............................................24 Figure 41. FIREBALL

  4. Unconventional High-Performance Laser Protection System Based on Dichroic Dye-Doped Cholesteric Liquid Crystals

    NASA Astrophysics Data System (ADS)

    Zhang, Wanshu; Zhang, Lanying; Liang, Xiao; Le Zhou; Xiao, Jiumei; Yu, Li; Li, Fasheng; Cao, Hui; Li, Kexuan; Yang, Zhou; Yang, Huai

    2017-02-01

    High-performance and cost-effective laser protection system is of crucial importance for the rapid advance of lasers in military and civilian fields leading to severe damages of human eyes and sensitive optical devices. However, it is crucially hindered by the angle-dependent protective effect and the complex preparation process. Here we demonstrate that angle-independence, good processibility, wavelength tunability, high optical density and good visibility can be effectuated simultaneously, by embedding dichroic anthraquinone dyes in a cholesteric liquid crystal matrix. More significantly, unconventional two-dimensional parabolic protection behavior is reported for the first time that in stark contrast to the existing protection systems, the overall parabolic protection behavior enables protective effect to increase with incident angles, hence providing omnibearing high-performance protection. The protective effect is controllable by dye concentration, LC cell thickness and CLC reflection efficiency, and the system can be made flexible enabling applications in flexible and even wearable protection devices. This research creates a promising avenue for the high-performance and cost-effective laser protection, and may foster the development of optical applications such as solar concentrators, car explosion-proof membrane, smart windows and polarizers.

  5. Telmisartan protects against diabetic vascular complications in a mouse model of obesity and type 2 diabetes, partially through peroxisome proliferator activated receptor-{gamma}-dependent activity

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Toyama, Kensuke; Nakamura, Taishi; Kataoka, Keiichiro

    2011-07-08

    Highlights: {yields} Telmisartan, an angiotensin receptor blocker, acts as a partial PPAR{gamma} agonist. {yields} The protective effects of telmisartan against diabetic vascular injury were associated with attenuation of vascular NF{kappa}B activation and TNF {alpha}. {yields} PPAR{gamma} activity of telmisartan was involved in the normalization of vascular PPAR{gamma} downregulation in diabetic mice. {yields} We provided the first evidence indicating that PPAR{gamma} activity of telmisartan contributed to the protective effects of telmisartan against diabetic vascular complication. -- Abstract: Experimental and clinical data support the notion that peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}) activation is associated with anti-atherosclerosis as well as anti-diabetic effect. Telmisartan,more » an angiotensin receptor blocker (ARB), acts as a partial PPAR{gamma} agonist. We hypothesized that telmisartan protects against diabetic vascular complications, through PPAR{gamma} activation. We compared the effects of telmisartan, telmisartan combined with GW9662 (a PPAR{gamma} antagonist), and losartan with no PPAR{gamma} activity on vascular injury in obese type 2 diabetic db/db mice. Compared to losartan, telmisartan significantly ameliorated vascular endothelial dysfunction, downregulation of phospho-eNOS, and coronary arterial remodeling in db/db mice. More vascular protective effects of telmisartan than losartan were associated with greater anti-inflammatory effects of telmisartan, as shown by attenuation of vascular nuclear factor kappa B (NF{kappa}B) activation and tumor necrosis factor {alpha}. Coadministration of GW9662 with telmisartan abolished the above mentioned greater protective effects of telmisartan against vascular injury than losartan in db/db mice. Thus, PPAR{gamma} activity appears to be involved in the vascular protective effects of telmisartan in db/db mice. Moreover, telmisartan, but not losartan, prevented the downregulation

  6. The bright side of plasmonic gold nanoparticles; activation of Nrf2, the cellular protective pathway

    NASA Astrophysics Data System (ADS)

    Goldstein, Alona; Soroka, Yoram; Frušić-Zlotkin, Marina; Lewis, Aaron; Kohen, Ron

    2016-06-01

    Plasmonic gold nanoparticles (AuNPs) are widely investigated for cancer therapy, due to their ability to strongly absorb light and convert it to heat and thus selectively destroy tumor cells. In this study we shed light on a new aspect of AuNPs and their plasmonic excitation, wherein they can provide anti-oxidant and anti-inflammatory protection by stimulating the cellular protective Nrf2 pathway. Our study was carried out on cells of the immune system, macrophages, and on skin cells, keratinocytes. A different response to AuNPs was noted in the two types of cells, explained by their distinct uptake profiles. In keratinocytes, the exposure to AuNPs, even at low concentrations, was sufficient to activate the Nrf2 pathway, without any irradiation, due to the presence of free AuNPs inside the cytosol. In contrast, in macrophages, the plasmonic excitation of the AuNPs by a low, non-lethal irradiation dose was required for their release from the constraining vesicles. The mechanism by which AuNPs activate the Nrf2 pathway was studied. Direct and indirect activation were suggested, based on the inherent ability of the AuNPs to react with thiol groups and to generate reactive oxygen species, in particular, under plasmonic excitation. The ability of AuNPs to directly activate the Nrf2 pathway renders them good candidates for treatment of disorders in which the up-regulation of Nrf2 is beneficial, specifically for topical treatment of inflammatory skin diseases.

  7. Respiratory protective device design using control system techniques

    NASA Technical Reports Server (NTRS)

    Burgess, W. A.; Yankovich, D.

    1972-01-01

    The feasibility of a control system analysis approach to provide a design base for respiratory protective devices is considered. A system design approach requires that all functions and components of the system be mathematically identified in a model of the RPD. The mathematical notations describe the operation of the components as closely as possible. The individual component mathematical descriptions are then combined to describe the complete RPD. Finally, analysis of the mathematical notation by control system theory is used to derive compensating component values that force the system to operate in a stable and predictable manner.

  8. Recent developments in aircraft protection systems for laser guide star operations

    NASA Astrophysics Data System (ADS)

    Stomski, Paul J.; Murphy, Thomas W.; Campbell, Randy

    2012-07-01

    The astronomical community's use of high power laser guide star adaptive optics (LGS-AO) systems presents a potential hazard to aviation. Historically, the most common and trusted means of protecting aircraft and their occupants has been the use of safety observers (aka spotters) armed with shut-off switches. These safety observers watch for aircraft at risk and terminate laser propagation before the aircraft can be adversely affected by the laser. Efforts to develop safer and more cost-effective automated aircraft protection systems for use by the astronomical community have been inhibited by both technological and regulatory challenges. This paper discusses recent developments in these two areas. Specifically, with regard to regulation and guidance we discuss the 2011 release of AS-6029 by the SAE as well as the potential impact of RTCA DO-278A. With regard to the recent developments in the technology used to protect aircraft from laser illumination, we discuss the novel Transponder Based Aircraft Detection (TBAD) system being installed at W. M. Keck Observatory (WMKO). Finally, we discuss our strategy for evaluating TBAD compliance with the regulations and for seeking appropriate approvals for LGS operations at WMKO using a fully automated, flexibly configured, multi-tier aircraft protection system incorporating this new technology.

  9. Short circuit protection for a power distribution system

    NASA Technical Reports Server (NTRS)

    Owen, J. R., III

    1969-01-01

    Sensing circuit detects when the output from a matrix is present and when it should be present. The circuit provides short circuit protection for a power distribution system where the selection of the driven load is accomplished by digital logic.

  10. Measuring benefits of protected area management: trends across realms and research gaps for freshwater systems.

    PubMed

    Adams, Vanessa M; Setterfield, Samantha A; Douglas, Michael M; Kennard, Mark J; Ferdinands, Keith

    2015-11-05

    Protected areas remain a cornerstone for global conservation. However, their effectiveness at halting biodiversity decline is not fully understood. Studies of protected area benefits have largely focused on measuring their impact on halting deforestation and have neglected to measure the impacts of protected areas on other threats. Evaluations that measure the impact of protected area management require more complex evaluation designs and datasets. This is the case across realms (terrestrial, freshwater, marine), but measuring the impact of protected area management in freshwater systems may be even more difficult owing to the high level of connectivity and potential for threat propagation within systems (e.g. downstream flow of pollution). We review the potential barriers to conducting impact evaluation for protected area management in freshwater systems. We contrast the barriers identified for freshwater systems to terrestrial systems and discuss potential measurable outcomes and confounders associated with protected area management across the two realms. We identify key research gaps in conducting impact evaluation in freshwater systems that relate to three of their major characteristics: variability, connectivity and time lags in outcomes. Lastly, we use Kakadu National Park world heritage area, the largest national park in Australia, as a case study to illustrate the challenges of measuring impacts of protected area management programmes for environmental outcomes in freshwater systems. © 2015 The Author(s).

  11. Measuring benefits of protected area management: trends across realms and research gaps for freshwater systems

    PubMed Central

    Adams, Vanessa M.; Setterfield, Samantha A.; Douglas, Michael M.; Kennard, Mark J.; Ferdinands, Keith

    2015-01-01

    Protected areas remain a cornerstone for global conservation. However, their effectiveness at halting biodiversity decline is not fully understood. Studies of protected area benefits have largely focused on measuring their impact on halting deforestation and have neglected to measure the impacts of protected areas on other threats. Evaluations that measure the impact of protected area management require more complex evaluation designs and datasets. This is the case across realms (terrestrial, freshwater, marine), but measuring the impact of protected area management in freshwater systems may be even more difficult owing to the high level of connectivity and potential for threat propagation within systems (e.g. downstream flow of pollution). We review the potential barriers to conducting impact evaluation for protected area management in freshwater systems. We contrast the barriers identified for freshwater systems to terrestrial systems and discuss potential measurable outcomes and confounders associated with protected area management across the two realms. We identify key research gaps in conducting impact evaluation in freshwater systems that relate to three of their major characteristics: variability, connectivity and time lags in outcomes. Lastly, we use Kakadu National Park world heritage area, the largest national park in Australia, as a case study to illustrate the challenges of measuring impacts of protected area management programmes for environmental outcomes in freshwater systems. PMID:26460127

  12. Protective activity of hamamelitannin on cell damage of murine skin fibroblasts induced by UVB irradiation.

    PubMed

    Masaki, H; Atsumi, T; Sakurai, H

    1995-07-01

    The protective activities of hamamelitannin (2',5-di-O-galloyl-hamamelose) in Hamamelis virginiana L. and its related compound, gallic acid, on damaged murine skin fibroblasts induced by UVB irradiation were investigated. In order to exclude the UV absorbing effect of the compounds, the protection study was performed such that the fibroblasts were pretreated with hamamelitannin or gallic acid for 24 h before UVB irradiation. At 200 microM concentration, hamamelitannin gave the higher survival of 72.6 +/- 0.4% in comparison with that of gallic acid (35.5 +/- 1.0%), while UVB absorbers such as 2-ethylhexyl p-methoxycinnamate and hexylbenzoate did not show such protection. The scavenging activities of hamamelitannin and gallic acid against active oxygens such as superoxide anion radicals, hydroxyl radicals and singlet oxygens were evaluated using electron spin resonance (ESR-spin trapping method). Hamamelitannin and gallic acid showed potent scavenging activities against all active oxygens tested. Furthermore, the association of hamamelitannin to fibroblasts was examined by comparing it with that of gallic acid, and the following results were obtained: (1) hamamelitannin reduces the reaction rate of liposome entrapped-nitroblue tetrazolium (NBT) with external superoxide anions, and (2) several glycosides associate with fibroblasts. From these results, it was concluded that hamamelitannin protects murine fibroblasts against external active oxygens by associating with the cell surface through its sugar moiety.

  13. High school youth and suicide risk: exploring protection afforded through physical activity and sport participation.

    PubMed

    Taliaferro, Lindsay A; Rienzo, Barbara A; Miller, M David; Pigg, R Morgan; Dodd, Virginia J

    2008-10-01

    Suicide ranks as the third leading cause of death for adolescents. Recent data from the Centers for Disease Control and Prevention (CDC) indicate that the adolescent suicide rate increased 18% between 2003 and 2004. Sport may represent a promising protective factor against adolescent suicide. This study examined the relative risk of hopelessness and suicidality associated with physical activity and sport participation. Data from the CDC's 2005 Youth Risk Behavior Survey were analyzed. Logistic regression modeling was used to compare the odds of hopelessness and suicidality in students who engaged in various levels of physical activity to inactive students. Similar analyses were performed comparing risks of athletes to nonathletes, and the risks of highly involved athletes to nonathletes. Findings showed that frequent, vigorous activity reduced the risk of hopelessness and suicidality among male adolescents. However, low levels of activity actually increased the risk of feeling hopeless among young females. Yet, for both males and females, sport participation protected against hopelessness and suicidality. These findings indicate that involvement in sport confers unique psychosocial benefits that protect adolescents against suicidality. Findings suggest that mechanisms other than physical activity contribute to the protective association between sport and reduced suicidality. Social support and integration may account for some of the differences found in suicidality between athletes and nonathletes.

  14. Anticipatory UPR Activation: A Protective Pathway and Target in Cancer

    PubMed Central

    Shapiro, David J.; Livezey, Mara; Yu, Liqun; Zheng, Xiaobin; Andruska, Neal

    2016-01-01

    The endoplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR), plays a key role in regulating intracellular protein homeostasis. The extensively studied reactive mode of UPR activation is characterized by unfolded protein, or other EnR stress, triggering UPR activation. Here we focus on the emerging anticipatory mode of UPR activation in which mitogenic steroid and peptide hormones and other effectors pre-activate the UPR and anticipate a future need for increased protein folding capacity. Mild UPR activation in breast cancer can be protective and contributes to antiestrogen resistance. Hyperactivation of the anticipatory UPR pathway in cancer cells with a small molecule converts it from cytoprotective to cytotoxic, highlighting its potential as a therapeutic target in estrogen receptor positive breast cancer. PMID:27354311

  15. AMPK activation by Tanshinone IIA protects neuronal cells from oxygen-glucose deprivation

    PubMed Central

    Weng, Yingfeng; Lin, Jixian; Liu, Hui; Wu, Hui; Yan, Zhimin; Zhao, Jing

    2018-01-01

    The current study tested the potential neuroprotective function of Tanshinone IIA (ThIIA) in neuronal cells with oxygen-glucose deprivation (ODG) and re-oxygenation (OGDR). In SH-SY5Y neuronal cells and primary murine cortical neurons, ThIIA pre-treatment attenuated OGDR-induced viability reduction and apoptosis. Further, OGDR-induced mitochondrial depolarization, reactive oxygen species production, lipid peroxidation and DNA damages in neuronal cells were significantly attenuated by ThIIA. ThIIA activated AMP-activated protein kinase (AMPK) signaling, which was essential for neuroprotection against OGDR. AMPKα1 knockdown or complete knockout in SH-SY5Y cells abolished ThIIA-induced AMPK activation and neuroprotection against OGDR. Further studies found that ThIIA up-regulated microRNA-135b to downregulate the AMPK phosphatase Ppm1e. Notably, knockdown of Ppm1e by targeted shRNA or forced microRNA-135b expression also activated AMPK and protected SH-SY5Y cells from OGDR. Together, AMPK activation by ThIIA protects neuronal cells from OGDR. microRNA-135b-mediated silence of Ppm1e could be the key mechanism of AMPK activation by ThIIA. PMID:29435120

  16. Application of Hybrid Real-Time Power System Simulator for Designing and Researching of Relay Protection and Automation

    NASA Astrophysics Data System (ADS)

    Borovikov, Yu S.; Sulaymanov, A. O.; Andreev, M. V.

    2015-10-01

    Development, research and operation of smart grids (SG) with active-adaptive networks (AAS) are actual tasks for today. Planned integration of high-speed FACTS devices greatly complicates complex dynamic properties of power systems. As a result the operating conditions of equipment of power systems are significantly changing. Such situation creates the new actual problem of development and research of relay protection and automation (RPA) which will be able to adequately operate in the SGs and adapt to its regimes. Effectiveness of solution of the problem depends on using tools - different simulators of electric power systems. Analysis of the most famous and widely exploited simulators led to the conclusion about the impossibility of using them for solution of the mentioned problem. In Tomsk Polytechnic University developed the prototype of hybrid multiprocessor software and hardware system - Hybrid Real-Time Power System Simulator (HRTSim). Because of its unique features this simulator can be used for solution of mentioned tasks. This article introduces the concept of development and research of relay protection and automation with usage of HRTSim.

  17. Engineering Aerothermal Analysis for X-34 Thermal Protection System Design

    NASA Technical Reports Server (NTRS)

    Wurster, Kathryn E.; Riley, Christopher J.; Zoby, E. Vincent

    1998-01-01

    Design of the thermal protection system for any hypersonic flight vehicle requires determination of both the peak temperatures over the surface and the heating-rate history along the flight profile. In this paper, the process used to generate the aerothermal environments required for the X-34 Testbed Technology Demonstrator thermal protection system design is described as it has evolved from a relatively simplistic approach based on engineering methods applied to critical areas to one of detailed analyses over the entire vehicle. A brief description of the trajectory development leading to the selection of the thermal protection system design trajectory is included. Comparisons of engineering heating predictions with wind-tunnel test data and with results obtained using a Navier-Stokes flowfield code and an inviscid/boundary layer method are shown. Good agreement is demonstrated among all these methods for both the ground-test condition and the peak heating flight condition. Finally, the detailed analysis using engineering methods to interpolate the surface-heating-rate results from the inviscid/boundary layer method to predict the required thermal environments is described and results presented.

  18. Engineering Aerothermal Analysis for X-34 Thermal Protection System Design

    NASA Technical Reports Server (NTRS)

    Wurster, Kathryn E.; Riley, Christopher J.; Zoby, E. Vincent

    1998-01-01

    Design of the thermal protection system for any hypersonic flight vehicle requires determination of both the peak temperatures over the surface and the heating-rate history along the flight profile. In this paper, the process used to generate the aerothermal environments required for the X-34 Testbed Technology Demonstrator thermal protection system design is described as it has evolved from a relatively simplistic approach based on engineering methods applied to critical areas to one of detailed analyses over the entire vehicle. A brief description of the trajectory development leading to the selection of the thermal protection system design trajectory is included. Comparisons of engineering heating predictions with wind-tunnel test data and with results obtained using a Navier- Stokes flowfield code and an inviscid/boundary layer method are shown. Good agreement is demonstrated among all these methods for both the ground-test condition and the peak heating flight condition. Finally, the detailed analysis using engineering methods to interpolate the surface-heating-rate results from the inviscid/boundary layer method to predict the required thermal environments is described and results presented.

  19. Protection of horses against Culicoides biting midges in different housing systems in Switzerland.

    PubMed

    Lincoln, V J; Page, P C; Kopp, C; Mathis, A; von Niederhäusern, R; Burger, D; Herholz, C

    2015-06-15

    Species belonging to the Culicoides complexes (Diptera, Ceratopogonidae), obsoletus and pulicaris, in Switzerland, are potential vectors of both bluetongue virus (BTV) and African horse sickness virus (AHSV). The epidemic of BTV in 2006 and 2007 in Europe has highlighted the risk of introduction and spread of vector-borne diseases in previously non-endemic areas. As a measure of prevention, as part of an integrated control programme in the event of an outbreak of African horse sickness (AHS), it is of utmost importance to prevent, or substantially reduce, contact between horses and Culicoides. The aim of the present study was to compare the effect of three protection systems, net, fan, repellent, or combinations thereof, with regard to their potential to reduce contact between horses and Culicoides. Three different equine housing systems, including individual boxes (BX), group housing systems (GR), and individual boxes with permanently accessible paddock (BP) were used. The efficacy of the protection systems were evaluated by comparing the total number counts of collected female Culicoides, of non-blood-fed and blood-fed Culicoides, respectively, with UV black light traps. The study was conducted over 3 summer months during 2012 and 2013 each and focused on the efficacy and practicality of the protection systems. The repellent was tested in 2012 only and not further investigated in 2013, as it showed no significant effect in reducing Culicoides collected in the light traps. Net protection system provided the best overall protection for the total number of female Culicoides, non-blood-fed and blood-fed Culicoides in all tested housing systems. The net, with a pore size of 0.1825 mm(2), reduced the total number of Culicoides collected in the housing systems BP, GR and BX by 98%, 85% and 67%, respectively. However, in the GR housing system, no significant difference between the effectiveness of the fan and the net were determined for any of the three Culicoides

  20. 29 CFR Appendix F to Subpart P of... - Selection of Protective Systems

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 8 2012-07-01 2012-07-01 false Selection of Protective Systems F Appendix F to Subpart P.... 1926, Subpt. P, App. F Appendix F to Subpart P of Part 1926—Selection of Protective Systems The following figures are a graphic summary of the requirements contained in subpart P for excavations 20 feet...

  1. 29 CFR Appendix F to Subpart P of... - Selection of Protective Systems

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 8 2014-07-01 2014-07-01 false Selection of Protective Systems F Appendix F to Subpart P.... 1926, Subpt. P, App. F Appendix F to Subpart P of Part 1926—Selection of Protective Systems The following figures are a graphic summary of the requirements contained in subpart P for excavations 20 feet...

  2. 29 CFR Appendix F to Subpart P of... - Selection of Protective Systems

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 8 2013-07-01 2013-07-01 false Selection of Protective Systems F Appendix F to Subpart P.... 1926, Subpt. P, App. F Appendix F to Subpart P of Part 1926—Selection of Protective Systems The following figures are a graphic summary of the requirements contained in subpart P for excavations 20 feet...

  3. 29 CFR Appendix F to Subpart P of... - Selection of Protective Systems

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 8 2011-07-01 2011-07-01 false Selection of Protective Systems F Appendix F to Subpart P.... 1926, Subpt. P, App. F Appendix F to Subpart P of Part 1926—Selection of Protective Systems The following figures are a graphic summary of the requirements contained in subpart P for excavations 20 feet...

  4. Donor pretreatment with adenosine monophosphate-activated protein kinase activator protects cardiac grafts from cold ischaemia/reperfusion injury.

    PubMed

    Yang, Chao; Xu, Honglai; Cai, Lanjun; Du, Xiaoxiao; Jiang, Yinan; Zhang, Yong; Zhou, Hongmin; Chen, Zhonghua Klaus

    2016-05-01

    Adenosine monophosphate-activated protein kinase (AMPK) is a master regulator of energy metabolism and has been shown to be protective in ischaemia/reperfusion injury (IRI). We hypothesized that preactivation of AMPK with an activator before donor heart procurement could protect heart grafts from cold IRI. Donor Sprague-Dawley rats were injected intravenously with AMPK activator 5-amino-imidazole-4-carboxamide ribonucleotide (AICAR) or vehicle 30 min before heart procurement. Heart grafts were then preserved in histidine-tryptophan-ketoglutarate (HTK) solution at 4°C for 8 h. After preservation, grafts were immediately mounted on the Langendorff perfusion system and perfused with Krebs-Henseleit buffer at 37°C for 1 h. Adenosine triphosphate (ATP) and malondialdehyde (MDA) content in graft tissue were quantified post-preservation and post-reperfusion. After reperfusion, isolated heart function was assessed using a pressure transducer; cumulative release of creatine kinase (CK) and lactate dehydrogenase (LDH) into the perfusate was measured to assess cardiomyocyte necrosis; ultrastructural changes in the mitochondria of the grafts were examined using transmission electron microscopy (TEM). After preservation, myocardial ATP content in the pretreated hearts was significantly higher than in the control hearts (3.247 ± 0.3034 vs 1.817 ± 0.2533 µmol/g protein; P < 0.05). AICAR-pretreated heart grafts exhibited significantly higher coronary flow (9.667 ± 0.3159 vs 8.033 ± 0.2459 ml/min; P < 0.05) and left ventricular developing pressure (58.67 ± 2.894 vs 42.67 ± 3.333 mmHg; P < 0.05) than the vehicle treated after reperfusion. Cumulative release of CK (300.0 ± 25.30 vs 431.7 ± 42.39 U/l; P < 0.05) and LDH (228.0 ± 16.68 vs 366.8 ± 57.41 U/l; P < 0.05) in the perfusate was significantly lower in the AICAR-pretreated group than that in the control group. Myocardial MDA content was also reduced in the pretreated group (0.5167 ± 0.1046 vs 0.9333 ± 0.1333 nmol

  5. Video copy protection and detection framework (VPD) for e-learning systems

    NASA Astrophysics Data System (ADS)

    ZandI, Babak; Doustarmoghaddam, Danial; Pour, Mahsa R.

    2013-03-01

    This Article reviews and compares the copyright issues related to the digital video files, which can be categorized as contended based and Digital watermarking copy Detection. Then we describe how to protect a digital video by using a special Video data hiding method and algorithm. We also discuss how to detect the copy right of the file, Based on expounding Direction of the technology of the video copy detection, and Combining with the own research results, brings forward a new video protection and copy detection approach in terms of plagiarism and e-learning systems using the video data hiding technology. Finally we introduce a framework for Video protection and detection in e-learning systems (VPD Framework).

  6. An Approximate Ablative Thermal Protection System Sizing Tool for Entry System Design

    NASA Technical Reports Server (NTRS)

    Dec, John A.; Braun, Robert D.

    2005-01-01

    A computer tool to perform entry vehicle ablative thermal protection systems sizing has been developed. Two options for calculating the thermal response are incorporated into the tool. One, an industry-standard, high-fidelity ablation and thermal response program was integrated into the tool, making use of simulated trajectory data to calculate its boundary conditions at the ablating surface. Second, an approximate method that uses heat of ablation data to estimate heat shield recession during entry has been coupled to a one-dimensional finite-difference calculation that calculates the in-depth thermal response. The in-depth solution accounts for material decomposition, but does not account for pyrolysis gas energy absorption through the material. Engineering correlations are used to estimate stagnation point convective and radiative heating as a function of time. The sizing tool calculates recovery enthalpy, wall enthalpy, surface pressure, and heat transfer coefficient. Verification of this tool is performed by comparison to past thermal protection system sizings for the Mars Pathfinder and Stardust entry systems and calculations are performed for an Apollo capsule entering the atmosphere at lunar and Mars return speeds.

  7. An Approximate Ablative Thermal Protection System Sizing Tool for Entry System Design

    NASA Technical Reports Server (NTRS)

    Dec, John A.; Braun, Robert D.

    2006-01-01

    A computer tool to perform entry vehicle ablative thermal protection systems sizing has been developed. Two options for calculating the thermal response are incorporated into the tool. One, an industry-standard, high-fidelity ablation and thermal response program was integrated into the tool, making use of simulated trajectory data to calculate its boundary conditions at the ablating surface. Second, an approximate method that uses heat of ablation data to estimate heat shield recession during entry has been coupled to a one-dimensional finite-difference calculation that calculates the in-depth thermal response. The in-depth solution accounts for material decomposition, but does not account for pyrolysis gas energy absorption through the material. Engineering correlations are used to estimate stagnation point convective and radiative heating as a function of time. The sizing tool calculates recovery enthalpy, wall enthalpy, surface pressure, and heat transfer coefficient. Verification of this tool is performed by comparison to past thermal protection system sizings for the Mars Pathfinder and Stardust entry systems and calculations are performed for an Apollo capsule entering the atmosphere at lunar and Mars return speeds.

  8. Reactor protection system with automatic self-testing and diagnostic

    DOEpatents

    Gaubatz, Donald C.

    1996-01-01

    A reactor protection system having four divisions, with quad redundant sensors for each scram parameter providing input to four independent microprocessor-based electronic chassis. Each electronic chassis acquires the scram parameter data from its own sensor, digitizes the information, and then transmits the sensor reading to the other three electronic chassis via optical fibers. To increase system availability and reduce false scrams, the reactor protection system employs two levels of voting on a need for reactor scram. The electronic chassis perform software divisional data processing, vote 2/3 with spare based upon information from all four sensors, and send the divisional scram signals to the hardware logic panel, which performs a 2/4 division vote on whether or not to initiate a reactor scram. Each chassis makes a divisional scram decision based on data from all sensors. Automatic detection and discrimination against failed sensors allows the reactor protection system to automatically enter a known state when sensor failures occur. Cross communication of sensor readings allows comparison of four theoretically "identical" values. This permits identification of sensor errors such as drift or malfunction. A diagnostic request for service is issued for errant sensor data. Automated self test and diagnostic monitoring, sensor input through output relay logic, virtually eliminate the need for manual surveillance testing. This provides an ability for each division to cross-check all divisions and to sense failures of the hardware logic.

  9. Reactor protection system with automatic self-testing and diagnostic

    DOEpatents

    Gaubatz, D.C.

    1996-12-17

    A reactor protection system is disclosed having four divisions, with quad redundant sensors for each scram parameter providing input to four independent microprocessor-based electronic chassis. Each electronic chassis acquires the scram parameter data from its own sensor, digitizes the information, and then transmits the sensor reading to the other three electronic chassis via optical fibers. To increase system availability and reduce false scrams, the reactor protection system employs two levels of voting on a need for reactor scram. The electronic chassis perform software divisional data processing, vote 2/3 with spare based upon information from all four sensors, and send the divisional scram signals to the hardware logic panel, which performs a 2/4 division vote on whether or not to initiate a reactor scram. Each chassis makes a divisional scram decision based on data from all sensors. Automatic detection and discrimination against failed sensors allows the reactor protection system to automatically enter a known state when sensor failures occur. Cross communication of sensor readings allows comparison of four theoretically ``identical`` values. This permits identification of sensor errors such as drift or malfunction. A diagnostic request for service is issued for errant sensor data. Automated self test and diagnostic monitoring, sensor input through output relay logic, virtually eliminate the need for manual surveillance testing. This provides an ability for each division to cross-check all divisions and to sense failures of the hardware logic. 16 figs.

  10. Thermal Protection System of the Space Shuttle

    NASA Technical Reports Server (NTRS)

    Cleland, John; Iannetti, Francesco

    1989-01-01

    The Thermal Protection System (TPS), introduced by NASA, continues to incorporate many of the advances in materials over the past two decades. A comprehensive, single-volume summary of the TPS, including system design rationales, key design features, and broad descriptions of the subsystems of TPS (E.g., reusable surface insulation, leading edge structural, and penetration subsystems) is provided. Details of all elements of TPS development and application are covered (materials properties, manufacturing, modeling, testing, installation, and inspection). Disclosures and inventions are listed and potential commercial application of TPS-related technology is discussed.

  11. Commercial application of thermal protection system technology

    NASA Technical Reports Server (NTRS)

    Dyer, Gordon L.

    1991-01-01

    The thermal protection system process technology is examined which is used in the manufacture of the External Tank for the Space Shuttle system and how that technology is applied by private business to create new products, new markets, and new American jobs. The term 'technology transfer' means different things to different people and has become one of the buzz words of the 1980s and 1990s. Herein, technology transfer is defined as a means of transferring technology developed by NASA's prime contractors to public and private sector industries.

  12. A Description of the Environmental Protection Agency's In-House Library Systems.

    ERIC Educational Resources Information Center

    Thomas, Sarah M.; Needle, Lester P.

    The Environmental Protection Agency's (EPA) inhouse library systems fall into two principle categories: basic library inventory systems and literature retrieval systems. Currently, the library network supports three inventory systems: the journal system; the hard bound book system; and the circulation system. At the same time, five efforts are…

  13. Medical Provider Ballistic Protection at Active Shooter Events.

    PubMed

    Stopyra, Jason P; Bozeman, William P; Callaway, David W; Winslow, James; McGinnis, Henderson D; Sempsrott, Justin; Evans-Taylor, Lisa; Alson, Roy L

    2016-01-01

    There is some controversy about whether ballistic protective equipment (body armor) is required for medical responders who may be called to respond to active shooter mass casualty incidents. In this article, we describe the ongoing evolution of recommendations to optimize medical care to injured victims at such an incident. We propose that body armor is not mandatory for medical responders participating in a rapid-response capacity, in keeping with the Hartford Consensus and Arlington Rescue Task Force models. However, we acknowledge that the development and implementation of these programs may benefit from the availability of such equipment as one component of risk mitigation. Many police agencies regularly retire body armor on a defined time schedule before the end of its effective service life. Coordination with law enforcement may allow such retired body armor to be available to other public safety agencies, such as fire and emergency medical services, providing some degree of ballistic protection to medical responders at little or no cost during the rare mass casualty incident. To provide visual demonstration of this concept, we tested three "retired" ballistic vests with ages ranging from 6 to 27 years. The vests were shot at close range using police-issue 9mm, .40 caliber, .45 caliber, and 12-gauge shotgun rounds. Photographs demonstrate that the vests maintained their ballistic protection and defeated all of these rounds. 2016.

  14. Suppressing active replication of a live attenuated simian immunodeficiency virus vaccine does not abrogate protection from challenge

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gabriel, Benjamin; Fiebig, Uwe; Hohn, Oliver

    Although safety concerns preclude the use of live attenuated HIV vaccines in humans, they provide a useful system for identifying the elusive correlates of protective immunity in the SIV/macaque animal model. However, a number of pieces of evidence suggest that protection may result from prior occupancy of susceptible target cells by the vaccine virus rather than the immune response. To address this, we developed a Nef-deletion variant of an RT-SHIV whose active replication could be shut off by treatment with RT-inhibitors. Groups of macaques were inoculated with the ∆Nef-RT-SHIV and immune responses allowed to develop before antiretroviral treatment and subsequentmore » challenge with wild-type SIVmac239. Vaccinated animals either resisted infection fully or significantly controlled the subsequent viremia. However, there was no difference between animals undergoing replication of the vaccine virus and those without. This strongly suggests that competition for available target cells does not play a role in protection. - Highlights: • A Nef-deleted RT-SHIV was used as a live attenuated vaccine in macaques. • Vaccine virus replication was shut down to investigate its role in protection. • Ongoing vaccine virus replication did not appear to be necessary for protection. • An analysis of T- and B-cell responses failed to identify a correlate of protection.« less

  15. 21 CFR 1240.86 - Protection of pier water system.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Protection of pier water system. 1240.86 Section 1240.86 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... interstate traffic shall make a connection between its nonpotable water system and any pier potable water...

  16. 21 CFR 1240.86 - Protection of pier water system.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Protection of pier water system. 1240.86 Section 1240.86 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... interstate traffic shall make a connection between its nonpotable water system and any pier potable water...

  17. 21 CFR 1240.86 - Protection of pier water system.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Protection of pier water system. 1240.86 Section 1240.86 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... interstate traffic shall make a connection between its nonpotable water system and any pier potable water...

  18. Protection of the Lifeless Environment in the Solar System

    NASA Astrophysics Data System (ADS)

    Almar, I.

    The main concern of planetary protection policy is how to protect the (hypothetical) extraterrestrial life against contamination and back-contamination. There is almost no interest in the preservation of the existing lifeless surfaces of extraterrestrial bodies, although some planetary transformation plans (in order to exploit hypothetical resources) were made public a long time ago. It should be remembered that planetary environments are practically unchanged since ages and damage caused by any human intervention would be irreversible. Our intention is not to prevent any commercial utilization of Solar System resources, but to make space exploration and exploitation of resources a controlled and well planned endeavor. The three main issues connected with the protection of the lifeless space environment are the following: 1/ The scientific aspect: a limited, well defined initiative to select by scientific investigation areas and objects of highest scientific priority on different celestial bodies. 2/ The legal aspect: to start the drafting of a declaration of principles supporting the protection of selected areas and objects on celestial bodies with a solid surface. It might evolve into an international legal instrument or treaty in order to limit the "free-for-all" intervention and use of Solar System resources. 3/ The societal aspect: to initiate a large scale discussion on the possible "ethical values" of the lifeless environment.

  19. Thermal Protection Materials and Systems: Past, Present, and Future

    NASA Technical Reports Server (NTRS)

    Johnson, Sylvia M.

    2013-01-01

    Thermal protection materials and systems (TPS) protect vehicles from the heat generated when entering a planetary atmosphere. NASA has developed many TPS systems over the years for vehicle ranging from planetary probes to crewed vehicles. The goal for all TPS is efficient and reliable performance. Efficient means using the right material for the environment and minimizing the mass of the heat shield without compromising safety. Efficiency is critical if the payload such as science experiments is to be maximized on a particular vehicle. Reliable means that we understand and can predict performance of the material. Although much characterization and testing of materials is performed to qualify and certify them for flight, it is not possible to completely recreate the reentry conditions in test facilities, and flight-testing

  20. Damage Detection/Locating System Providing Thermal Protection

    NASA Technical Reports Server (NTRS)

    Woodard, Stanley E. (Inventor); Jones, Thomas W. (Inventor); Taylor, Bryant D. (Inventor); Qamar, A. Shams (Inventor)

    2010-01-01

    A damage locating system also provides thermal protection. An array of sensors substantially tiles an area of interest. Each sensor is a reflective-surface conductor having operatively coupled inductance and capacitance. A magnetic field response recorder is provided to interrogate each sensor before and after a damage condition. Changes in response are indicative of damage and a corresponding location thereof.

  1. HSP70 protects rats and hippocampal neurons from central nervous system oxygen toxicity by suppression of NO production and NF-κB activation.

    PubMed

    Yi, Hongjie; Huang, Guoyang; Zhang, Kun; Liu, Shulin; Xu, Weigang

    2018-05-01

    protein 70-overexpression decreased the nitric oxide, nitric oxide synthase, and inducible nitric oxide synthase levels as well as the cytoplasm/nucleus ratio of nuclear factor-κB and protected neurons from hyperbaric oxygen-induced cell injury. In conclusion, overexpression of heat shock protein 70 in hippocampal neurons may protect rats from central nervous system oxygen toxicity by suppression of neuronal nitric oxide synthase and inducible nitric oxide synthase-mediated nitric oxide production and translocation of nuclear factor-κB to nucleus. Impact statement Because the pathogenesis of central nervous system oxygen toxicity (CNS-OT) remains unclear, there are few interventions available. To develop an efficient strategy against CNS-OT, it is necessary to understand its pathogenesis and in particular, the relevant key factors involved. This study examined the protective effects of heat shock protein 70 (HSP70) on CNS-OT via in vivo and in vitro experiments. Our results indicated that overexpression of HSP70 in hippocampal neurons may protect rats from CNS-OT by suppression of nNOS and iNOS-mediated NO production and the activation of NF-κB. These findings contribute to clarification of the role of HSP70 in CNS-OT and provide us a potential novel target to prevent CNS-OT. Clarification of the involvement of NO, NOS and NF-κB provides new insights into the mechanism of CNS-OT and may help us to develop new approach against it by interfering these molecules.

  2. Intelligent vehicle electrical power supply system with central coordinated protection

    NASA Astrophysics Data System (ADS)

    Yang, Diange; Kong, Weiwei; Li, Bing; Lian, Xiaomin

    2016-07-01

    The current research of vehicle electrical power supply system mainly focuses on electric vehicles (EV) and hybrid electric vehicles (HEV). The vehicle electrical power supply system used in traditional fuel vehicles is rather simple and imperfect; electrical/electronic devices (EEDs) applied in vehicles are usually directly connected with the vehicle's battery. With increasing numbers of EEDs being applied in traditional fuel vehicles, vehicle electrical power supply systems should be optimized and improved so that they can work more safely and more effectively. In this paper, a new vehicle electrical power supply system for traditional fuel vehicles, which accounts for all electrical/electronic devices and complex work conditions, is proposed based on a smart electrical/electronic device (SEED) system. Working as an independent intelligent electrical power supply network, the proposed system is isolated from the electrical control module and communication network, and access to the vehicle system is made through a bus interface. This results in a clean controller power supply with no electromagnetic interference. A new practical battery state of charge (SoC) estimation method is also proposed to achieve more accurate SoC estimation for lead-acid batteries in traditional fuel vehicles so that the intelligent power system can monitor the status of the battery for an over-current state in each power channel. Optimized protection methods are also used to ensure power supply safety. Experiments and tests on a traditional fuel vehicle are performed, and the results reveal that the battery SoC is calculated quickly and sufficiently accurately for battery over-discharge protection. Over-current protection is achieved, and the entire vehicle's power utilization is optimized. For traditional fuel vehicles, the proposed vehicle electrical power supply system is comprehensive and has a unified system architecture, enhancing system reliability and security.

  3. Focal role of tolerability and reasonableness in the radiological protection system.

    PubMed

    Schneider, T; Lochard, J; Vaillant, L

    2016-06-01

    The concepts of tolerability and reasonableness are at the core of the International Commission on Radiological Protection (ICRP) system of radiological protection. Tolerability allows the definition of boundaries for implementing ICRP principles, while reasonableness contributes to decisions regarding adequate levels of protection, taking into account the prevailing circumstances. In the 1970s and 1980s, attempts to find theoretical foundations in risk comparisons for tolerability and cost-benefit analysis for reasonableness failed. In practice, the search for a rational basis for these concepts will never end. Making a wise decision will always remain a matter of judgement and will depend on the circumstances as well as the current knowledge and past experience. This paper discusses the constituents of tolerability and reasonableness at the heart of the radiological protection system. It also emphasises the increasing role of stakeholder engagement in the quest for tolerability and reasonableness since Publication 103. © The International Society for Prosthetics and Orthotics.

  4. Actin and DNA Protect Histones from Degradation by Bacterial Proteases but Inhibit Their Antimicrobial Activity

    PubMed Central

    Sol, Asaf; Skvirsky, Yaniv; Blotnick, Edna; Bachrach, Gilad; Muhlrad, Andras

    2016-01-01

    Histones are small polycationic proteins located in the cell nucleus. Together, DNA and histones are integral constituents of the nucleosomes. Upon apoptosis, necrosis, and infection – induced cell death, histones are released from the cell. The extracellular histones have strong antimicrobial activity but are also cytotoxic and thought as mediators of cell death in sepsis. The antimicrobial activity of the cationic extracellular histones is inhibited by the polyanionic DNA and F-actin, which also become extracellular upon cell death. DNA and F-actin protect histones from degradation by the proteases of Pseudomonas aeruginosa and Porphyromonas gingivalis. However, though the integrity of the histones is protected, the activity of histones as antibacterial agents is lost. The inhibition of the histone’s antibacterial activity and their protection from proteolysis by DNA and F-actin indicate a tight electrostatic interaction between the positively charged histones and negatively charged DNA and F-actin, which may have physiological significance in maintaining the equilibrium between the beneficial antimicrobial activity of extracellular histones and their cytotoxic effects. PMID:27555840

  5. Glutaredoxin 2 prevents H(2)O(2)-induced cell apoptosis by protecting complex I activity in the mitochondria.

    PubMed

    Wu, Hongli; Xing, Kuiyi; Lou, Marjorie F

    2010-10-01

    Glutaredoxin 2 (Grx2) belongs to the oxidoreductase family and is an isozyme of glutaredoxin 1 (Grx1) present in the mitochondria, however its function is not well understood. The purpose of this study is to evaluate the potential anti-apoptotic function of Grx2 by examining its ability to protect complex I in the mitochondrial electron transport system using human lens epithelial cells as a model. We found that cells treated with 200muM hydrogen peroxide (H(2)O(2)) for 24h exhibited decreased viability and became apoptotic with corresponding Bax up-regulation, Bcl-2 down-regulation, caspase 3 activation and mitochondrial cytochrome c leakage. Grx2 over-expression (OE) could protect cells against H(2)O(2)-induced damage while Grx2 knockdown (KD) showed the opposite effect. Under the same conditions, H(2)O(2) treatment caused 50% inactivation of complex I activity in control cells (vector only), 75% in Grx2 KD cells but only 20% in Grx2 OE cells. Furthermore, the inactivated complex I in the H(2)O(2)-treated cells could be protected mostly by importing the purified nascent Grx2 protein, but not the Grx2 protein mutated at the active site with C70S, or C73S, or with C70S plus C73S. Immunoprecipitation study also revealed that Grx2 co-precipitated with complex I, but not complex II, in the mitochondrial lysate. Thus, the mechanism of Grx2 protection against H(2)O(2)-induced apoptosis is likely associated with its ability to preserve complex I. Published by Elsevier B.V.

  6. TREAT Reactor Control and Protection System

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lipinski, W.C.; Brookshier, W.K.; Burrows, D.R.

    1985-01-01

    The main control algorithm of the Transient Reactor Test Facility (TREAT) Automatic Reactor Control System (ARCS) resides in Read Only Memory (ROM) and only experiment specific parameters are input via keyboard entry. Prior to executing an experiment, the software and hardware of the control computer is tested by a closed loop real-time simulation. Two computers with parallel processing are used for the reactor simulation and another computer is used for simulation of the control rod system. A monitor computer, used as a redundant diverse reactor protection channel, uses more conservative setpoints and reduces challenges to the Reactor Trip System (RTS).more » The RTS consists of triplicated hardwired channels with one out of three logic. The RTS is automatically tested by a digital Dedicated Microprocessor Tester (DMT) prior to the execution of an experiment. 6 refs., 5 figs., 1 tab.« less

  7. New keratin isolates: actives for natural hair protection.

    PubMed

    Roddick-Lanzilotta, Alisa; Kelly, Rob; Scott, Sonya; Chahal, Surinder

    2007-01-01

    Hair is primarily composed of keratin proteins and it is well established that peptides and proteins bestow desirable effects on the hair, for example improving moisturization and softness. In the present work we describe how keratin actives with unique properties convey a range of beneficial properties to a variety of hair types. It has been observed that these functional keratins protect hair from damage associated with chemical treatments such as perming and relaxation, help to restore the mechanical strength of damaged fibers and decrease fading of colored hair.

  8. Selective aliphatic carbon-hydrogen bond activation of protected alcohol substrates by cytochrome P450 enzymes.

    PubMed

    Bell, Stephen G; Spence, Justin T J; Liu, Shenglan; George, Jonathan H; Wong, Luet-Lok

    2014-04-21

    Protected cyclohexanol and cyclohex-2-enol substrates, containing benzyl ether and benzoate ester moieties, were designed to fit into the active site of the Tyr96Ala mutant of cytochrome P450cam. The protected cyclohexanol substrates were efficiently and selectively hydroxylated by the mutant enzyme at the trans C-H bond of C-4 on the cyclohexyl ring. The selectivity of oxidation of the benzoate ester protected cyclohexanol could be altered by making alternative amino acid substitutions in the P450cam active site. The addition of the double bond in the cyclohexyl ring of the benzoate ester protected cyclohex-2-enol has a debilitative effect on the activity of the Tyr96Ala mutant with this substrate. However, the Phe87Ala/Tyr96Phe double mutant, which introduces space at a different location in the active site than the Tyr96Ala mutant, was able to efficiently hydroxylate the C-H bonds of 1-cyclohex-2-enyl benzoate at the allylic C-4 position. Mutations at Phe87 improved the selectivity of the oxidation of 1-phenyl-1-cyclohexylethylene to trans-4-phenyl-ethenylcyclohexanol (92%) when compared to single mutants at Tyr96 of P450cam.

  9. Transient thermal analysis of a titanium multiwall thermal protection system

    NASA Technical Reports Server (NTRS)

    Blosser, M. L.

    1982-01-01

    The application of the SPAR thermal analyzer to the thermal analysis of a thermal protection system concept is discussed. The titanium multiwall thermal protection system concept consists of alternate flat and dimpled sheets which are joined together at the crests of the dimples and formed into 30 cm by 30 cm (12 in. by 12 in.) tiles. The tiles are mechanically attached to the structure. The complex tile geometry complicates thermal analysis. Three modes of heat transfer were considered: conduction through the gas inside the tile, conduction through the metal, and radiation between the various layers. The voids between the dimpled and flat sheets were designed to be small enough so that natural convection is insignificant (e.g., Grashof number 1000). A two step approach was used in the thermal analysis of the multiwall thermal protection system. First, an effective normal (through-the-thickness) thermal conductivity was obtained from a steady state analysis using a detailed SPAR finite element model of a small symmetric section of the multiwall tile. This effective conductivity was then used in simple one dimensional finite element models for preliminary analysis of several transient heat transfer problems.

  10. An arc control and protection system for the JET lower hybrid antenna based on an imaging system

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Figueiredo, J., E-mail: joao.figueiredo@jet.efda.org; Mailloux, J.; Kirov, K.

    Arcs are the potentially most dangerous events related to Lower Hybrid (LH) antenna operation. If left uncontrolled they can produce damage and cause plasma disruption by impurity influx. To address this issue an arc real time control and protection imaging system for the Joint European Torus (JET) LH antenna has been implemented. The LH system is one of the additional heating systems at JET. It comprises 24 microwave generators (klystrons, operating at 3.7 GHz) providing up to 5 MW of heating and current drive to the JET plasma. This is done through an antenna composed of an array of waveguidesmore » facing the plasma. The protection system presented here is based primarily on an imaging arc detection and real time control system. It has adapted the ITER like wall hotspot protection system using an identical CCD camera and real time image processing unit. A filter has been installed to avoid saturation and spurious system triggers caused by ionization light. The antenna is divided in 24 Regions Of Interest (ROIs) each one corresponding to one klystron. If an arc precursor is detected in a ROI, power is reduced locally with subsequent potential damage and plasma disruption avoided. The power is subsequently reinstated if, during a defined interval of time, arcing is confirmed not to be present by image analysis. This system was successfully commissioned during the restart phase and beginning of the 2013 scientific campaign. Since its installation and commissioning, arcs and related phenomena have been prevented. In this contribution we briefly describe the camera, image processing, and real time control systems. Most importantly, we demonstrate that an LH antenna arc protection system based on CCD camera imaging systems works. Examples of both controlled and uncontrolled LH arc events and their consequences are shown.« less

  11. An arc control and protection system for the JET lower hybrid antenna based on an imaging system.

    PubMed

    Figueiredo, J; Mailloux, J; Kirov, K; Kinna, D; Stamp, M; Devaux, S; Arnoux, G; Edwards, J S; Stephen, A V; McCullen, P; Hogben, C

    2014-11-01

    Arcs are the potentially most dangerous events related to Lower Hybrid (LH) antenna operation. If left uncontrolled they can produce damage and cause plasma disruption by impurity influx. To address this issue an arc real time control and protection imaging system for the Joint European Torus (JET) LH antenna has been implemented. The LH system is one of the additional heating systems at JET. It comprises 24 microwave generators (klystrons, operating at 3.7 GHz) providing up to 5 MW of heating and current drive to the JET plasma. This is done through an antenna composed of an array of waveguides facing the plasma. The protection system presented here is based primarily on an imaging arc detection and real time control system. It has adapted the ITER like wall hotspot protection system using an identical CCD camera and real time image processing unit. A filter has been installed to avoid saturation and spurious system triggers caused by ionization light. The antenna is divided in 24 Regions Of Interest (ROIs) each one corresponding to one klystron. If an arc precursor is detected in a ROI, power is reduced locally with subsequent potential damage and plasma disruption avoided. The power is subsequently reinstated if, during a defined interval of time, arcing is confirmed not to be present by image analysis. This system was successfully commissioned during the restart phase and beginning of the 2013 scientific campaign. Since its installation and commissioning, arcs and related phenomena have been prevented. In this contribution we briefly describe the camera, image processing, and real time control systems. Most importantly, we demonstrate that an LH antenna arc protection system based on CCD camera imaging systems works. Examples of both controlled and uncontrolled LH arc events and their consequences are shown.

  12. Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Son, Tae Gen; Kawamoto, Elisa M.; Yu, Qian-Sheng

    2013-04-19

    Highlights: •Naphthazarin activates the Nrf2/ARE pathway. •Naphthazarin induces Nrf2-driven genes in neurons and astrocytes. •Naphthazarin protects neurons against excitotoxicity. -- Abstract: Nuclear factor E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is an important cellular stress response pathway involved in neuroprotection. We previously screened several natural phytochemicals and identified plumbagin as a novel activator of the Nrf2/ARE pathway that can protect neurons against ischemic injury. Here we extended our studies to natural and synthetic derivatives of plumbagin. We found that 5,8-dimethoxy-1,4-naphthoquinone (naphthazarin) is a potent activator of the Nrf2/ARE pathway, up-regulates the expression of Nrf2-driven genes in primary neuronal andmore » glial cultures, and protects neurons against glutamate-induced excitotoxicity.« less

  13. Valve system incorporating single failure protection logic

    DOEpatents

    Ryan, Rodger; Timmerman, Walter J. H.

    1980-01-01

    A valve system incorporating single failure protective logic. The system consists of a valve combination or composite valve which allows actuation or de-actuation of a device such as a hydraulic cylinder or other mechanism, integral with or separate from the valve assembly, by means of three independent input signals combined in a function commonly known as two-out-of-three logic. Using the input signals as independent and redundant actuation/de-actuation signals, a single signal failure, or failure of the corresponding valve or valve set, will neither prevent the desired action, nor cause the undesired action of the mechanism.

  14. [Effect of immune modulation on immunogenic and protective activity of a live plague vaccine].

    PubMed

    Karal'nik, B V; Ponomareva, T S; Deriabin, P N; Denisova, T G; Mel'nikova, N N; Tugambaev, T I; Atshabar, B B; Zakarian, S B

    2014-01-01

    Comparative evaluation of the effect of polyoxidonium and betaleukin on immunogenic and protective activity of a live plague vaccine in model animal experiments. Plague vaccine EV, polyoxidonium, betaleukin, erythrocytic antigenic diagnosticum for determination of F1 antibodies and immune reagents for detection of lymphocytes with F1 receptors (LFR) in adhesive test developed by the authors were used. The experiments were carried out in 12 rabbits and 169 guinea pigs. Immune modulation accelerated the appearance and disappearance of LFR (early phase) and ensured a more rapid and intensive antibody formation (effector phase). Activation by betaleukin is more pronounced than by polyoxidonium. The more rapid and intensive was the development of early phase, the more effective was antibody response to the vaccine. Immune modulation in the experiment with guinea pigs significantly increased protective activity of the vaccine. The use of immune modulators increased immunogenic (in both early and effector phases of antigen-specific response) and protective activity of the EV vaccine. A connection between the acceleration of the first phase of antigen-specific response and general intensity of effector phase of immune response to the EV vaccine was detected. ,

  15. 75 FR 16676 - Airworthiness Standards; Electrical and Electronic System Lightning Protection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... systems that allow them to operate into instrument meteorological conditions (IMC), where lightning... 27 standards that operate in VFR-only operations with electrical or electronic systems installed for... Airworthiness Standards; Electrical and Electronic System Lightning Protection AGENCY: Federal Aviation...

  16. The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system.

    PubMed

    Tinker, Andrew; Aziz, Qadeer; Thomas, Alison

    2014-01-01

    ATP-sensitive potassium channels (K(ATP)) are widely distributed and present in a number of tissues including muscle, pancreatic beta cells and the brain. Their activity is regulated by adenine nucleotides, characteristically being activated by falling ATP and rising ADP levels. Thus, they link cellular metabolism with membrane excitability. Recent studies using genetically modified mice and genomic studies in patients have implicated K(ATP) channels in a number of physiological and pathological processes. In this review, we focus on their role in cellular function and protection particularly in the cardiovascular system. © 2013 The British Pharmacological Society.

  17. Laboratory evaluation of a pilot cell battery protection system for photovoltaic applications

    NASA Technical Reports Server (NTRS)

    Cataldo, R. L.; Thomas, R. D.

    1981-01-01

    An energy storage method for the 3.5 kW battery power system was investigated. The Pilot Cell Battery Protection System was tested for use in photovoltaic power systems and results show that this is a viable method of storage battery control. The method of limiting battery depth of discharge has the following advantages: (1) temperature sensitivity; (2) rate sensitivity; and (3) state of charge indication. The pilot cell concept is of interest in remote stand alone photovoltaic power systems. The battery can be protected from damaging overdischarge by using the proper ratio of pilot cell capacities to main battery capacity.

  18. Factors that deregulate the protective immune response in tuberculosis.

    PubMed

    Hernandez-Pando, Rogelio; Orozco, Hector; Aguilar, Diana

    2009-01-01

    Tuberculosis (TB) is a chronic infectious disease which essentially affects the lungs and produces profound abnormalities on the immune system. Although most people infected by the tubercle bacillus (90%) do not develop the disease during their lifetime, when there are alterations in the immune system, such as co-infection with HIV, malnutrition, or diabetes, the risk of developing active disease increases considerably. Interestingly, during the course of active disease, even in the absence of immunosuppressive conditions, there is a profound and prolonged suppression of Mycobacterium tuberculosis-specific protective immune responses. Several immune factors can contribute to downregulate the protective immunity, permitting disease progression. In general, many of these factors are potent anti-inflammatory molecules that are probably overproduced with the intention to protect against tissue damage, but the consequence of this response is a decline in protective immunity facilitating bacilli growth and disease progression. Here the most significant participants in protective immunity are reviewed, in particular the factors that deregulate protective immunity in TB. Their manipulation as novel forms of immunotherapy are also briefly commented.

  19. Impact Testing of Orbiter Thermal Protection System Materials

    NASA Technical Reports Server (NTRS)

    Kerr, Justin

    2006-01-01

    This viewgraph presentation reviews the impact testing of the materials used in designing the shuttle orbiter thermal protection system (TPS). Pursuant to the Columbia Accident Investigation Board recommendations a testing program of the TPS system was instituted. This involved using various types of impactors in different sizes shot from various sizes and strengths guns to impact the TPS tiles and the Leading Edge Structural Subsystem (LESS). The observed damage is shown, and the resultant lessons learned are reviewed.

  20. "TPSX: Thermal Protection System Expert and Material Property Database"

    NASA Technical Reports Server (NTRS)

    Squire, Thomas H.; Milos, Frank S.; Rasky, Daniel J. (Technical Monitor)

    1997-01-01

    The Thermal Protection Branch at NASA Ames Research Center has developed a computer program for storing, organizing, and accessing information about thermal protection materials. The program, called Thermal Protection Systems Expert and Material Property Database, or TPSX, is available for the Microsoft Windows operating system. An "on-line" version is also accessible on the World Wide Web. TPSX is designed to be a high-quality source for TPS material properties presented in a convenient, easily accessible form for use by engineers and researchers in the field of high-speed vehicle design. Data can be displayed and printed in several formats. An information window displays a brief description of the material with properties at standard pressure and temperature. A spread sheet window displays complete, detailed property information. Properties which are a function of temperature and/or pressure can be displayed as graphs. In any display the data can be converted from English to SI units with the click of a button. Two material databases included with TPSX are: 1) materials used and/or developed by the Thermal Protection Branch at NASA Ames Research Center, and 2) a database compiled by NASA Johnson Space Center 9JSC). The Ames database contains over 60 advanced TPS materials including flexible blankets, rigid ceramic tiles, and ultra-high temperature ceramics. The JSC database contains over 130 insulative and structural materials. The Ames database is periodically updated and expanded as required to include newly developed materials and material property refinements.

  1. Marine Protected Dramas: The Flaws of the Brazilian National System of Marine Protected Areas

    NASA Astrophysics Data System (ADS)

    Gerhardinger, Leopoldo C.; Godoy, Eduardo A. S.; Jones, Peter J. S.; Sales, Gilberto; Ferreira, Beatrice P.

    2011-04-01

    This article discusses the current problems and issues associated with the implementation of a National System of Marine Protected Areas in Brazil. MPA managers and higher governmental level authorities were interviewed about their perceptions of the implementation of a national MPA strategy and the recent changes in the institutional arrangement of government marine conservation agencies. Interviewees' narratives were generally pessimistic and the National System was perceived as weak, with few recognizable marine conservation outcomes on the ground. The following major flaws were identified: poor inter-institutional coordination of coastal and ocean governance; institutional crisis faced by the national government marine conservation agency; poor management within individual MPAs; problems with regional networks of marine protected areas; an overly bureaucratic management and administrative system; financial shortages creating structural problems and a disconnect between MPA policy and its delivery. Furthermore, a lack of professional motivation and a pessimistic atmosphere was encountered during many interviews, a malaise which we believe affects how the entire system is able to respond to crises. Our findings highlight the need for a better understanding of the role of `leadership' in the performance of socio-ecological systems (such as MPA networks), more effective official evaluation mechanisms, more localized audits of (and reforms if necessary to) Brazil's federal biodiversity conservation agency (ICMBio), and the need for political measures to promote state leadership and support. Continuing to focus on the designation of more MPAs whilst not fully addressing these issues will achieve little beyond fulfilling, on paper, Brazil's international marine biodiversity commitments.

  2. Marine protected dramas: the flaws of the Brazilian National System of Marine Protected Areas.

    PubMed

    Gerhardinger, Leopoldo C; Godoy, Eduardo A S; Jones, Peter J S; Sales, Gilberto; Ferreira, Beatrice P

    2011-04-01

    This article discusses the current problems and issues associated with the implementation of a National System of Marine Protected Areas in Brazil. MPA managers and higher governmental level authorities were interviewed about their perceptions of the implementation of a national MPA strategy and the recent changes in the institutional arrangement of government marine conservation agencies. Interviewees' narratives were generally pessimistic and the National System was perceived as weak, with few recognizable marine conservation outcomes on the ground. The following major flaws were identified: poor inter-institutional coordination of coastal and ocean governance; institutional crisis faced by the national government marine conservation agency; poor management within individual MPAs; problems with regional networks of marine protected areas; an overly bureaucratic management and administrative system; financial shortages creating structural problems and a disconnect between MPA policy and its delivery. Furthermore, a lack of professional motivation and a pessimistic atmosphere was encountered during many interviews, a malaise which we believe affects how the entire system is able to respond to crises. Our findings highlight the need for a better understanding of the role of 'leadership' in the performance of socio-ecological systems (such as MPA networks), more effective official evaluation mechanisms, more localized audits of (and reforms if necessary to) Brazil's federal biodiversity conservation agency (ICMBio), and the need for political measures to promote state leadership and support. Continuing to focus on the designation of more MPAs whilst not fully addressing these issues will achieve little beyond fulfilling, on paper, Brazil's international marine biodiversity commitments.

  3. R-spondin3-LGR4 signaling protects hepatocytes against DMOG-induced hypoxia/reoxygenation injury through activating β-catenin.

    PubMed

    Liu, Shiying; Yin, Yue; Yu, Ruili; Li, Yin; Zhang, Weizhen

    2018-04-30

    Leucine-rich repeat G-protein-coupled receptor 4 (LGR4) and its ligands R-spondin1-4 (Rspos) have been vastly investigated in embryonic development. The biological functions of Rspos-LGR4 system in liver remains largely unknown. Here, we explored whether it protects hepatocytes against hypoxia/reoxygenation (H/R) induced damage. H/R injury was induced by dimethyloxalylglycine (DMOG) in AML12 cells and the effects of Rspo3 on cell proliferation and apoptosis were assessed. Specific shRNAs were used to interfere LGR4 or β-catenin. DMOG caused hepatocytes damage evidenced by increase in HIF-1α, cell death and apoptosis genes p27 and Bax, with concurrent decrease of cell proliferation genes PCNA and CyclinD1. Of all the Rspos, Rspo3 is predominantly expressed in AML12 hepatocytes. Importantly, Rspo3 demonstrated an alteration in a manner similar to proliferation-related genes during H/R injury. Rspo3 pretreatment rendered hepatocytes less vulnerable to DMOG induced H/R injury. Ablation of LGR4 using shRNA attenuated the protective effects of Rspo3. Wnt3a also protected AML12 cells from damages caused by H/R, showing enhanced proliferation activity. Notably, knockdown of β-catenin in hepatocytes completely abolished the effect of Rspo3 pretreatment on the expression levels of PCNA and CyclinD1. Rspo3-LGR4 axis protects hepatocytes from H/R injury via activating β-catenin. Copyright © 2018. Published by Elsevier Inc.

  4. 78 FR 62644 - Agency Information Collection Activities: Application for Temporary Protected Status, Form I-821...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Citizenship and Immigration Services [OMB Control Number 1615-0043] Agency Information Collection Activities: Application for Temporary Protected Status, Form I-821... Currently Approved Collection. (2) Title of the Form/Collection: Application for Temporary Protected Status...

  5. Research on laser protection: an overview of 20 years of activities at Fraunhofer IOSB

    NASA Astrophysics Data System (ADS)

    Ritt, G.; Walter, D.; Eberle, B.

    2013-10-01

    Since the advent of the laser in 1960, the protection of human eyes and sensors against intended or unintended damage by laser radiation is a hot research topic. As long as the parameters of a laser source such as the wavelength and the output power are known, adequate laser safety can be ensured simply by utilizing conventional laser protection filters which are based on absorption or interference effects. This is typically the case in cooperative environments like a laboratory or industrial facilities. A very different situation prevails in military defense or civil security. There, the parameters of encountering laser threats are usually unknown. Protection measures, helping against all types of laser threats, are the long desired objective of countless research activities. The biggest challenge in finding an effective measure arises from single laser pulses of unknown wavelength. The problem demands for a passive protection concept and may be based for example on intensity dependent effects. Moreover, the requested solutions shall comprise add-on possibilities like thin films to be put on existing optics, windshields or glasses. Unfortunately, such an all-embracing solution is still far out of reach. The Fraunhofer IOSB has been working on the evaluation and development of non-conventional laser protection methods for more than 20 years. An overview of the past and present research activities shall be presented, comprising protection measures against laser damaging and laser dazzling.

  6. A reference model for model-based design of critical infrastructure protection systems

    NASA Astrophysics Data System (ADS)

    Shin, Young Don; Park, Cheol Young; Lee, Jae-Chon

    2015-05-01

    Today's war field environment is getting versatile as the activities of unconventional wars such as terrorist attacks and cyber-attacks have noticeably increased lately. The damage caused by such unconventional wars has also turned out to be serious particularly if targets are critical infrastructures that are constructed in support of banking and finance, transportation, power, information and communication, government, and so on. The critical infrastructures are usually interconnected to each other and thus are very vulnerable to attack. As such, to ensure the security of critical infrastructures is very important and thus the concept of critical infrastructure protection (CIP) has come. The program to realize the CIP at national level becomes the form of statute in each country. On the other hand, it is also needed to protect each individual critical infrastructure. The objective of this paper is to study on an effort to do so, which can be called the CIP system (CIPS). There could be a variety of ways to design CIPS's. Instead of considering the design of each individual CIPS, a reference model-based approach is taken in this paper. The reference model represents the design of all the CIPS's that have many design elements in common. In addition, the development of the reference model is also carried out using a variety of model diagrams. The modeling language used therein is the systems modeling language (SysML), which was developed and is managed by Object Management Group (OMG) and a de facto standard. Using SysML, the structure and operational concept of the reference model are designed to fulfil the goal of CIPS's, resulting in the block definition and activity diagrams. As a case study, the operational scenario of the nuclear power plant while being attacked by terrorists is studied using the reference model. The effectiveness of the results is also analyzed using multiple analysis models. It is thus expected that the approach taken here has some merits

  7. 29 CFR 1926.652 - Requirements for protective systems.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... no indication of a potential cave-in. (2) Protective systems shall have the capacity to resist without failure all loads that are intended or could reasonably be expected to be applied or transmitted... person cannot assure the material or equipment is able to support the intended loads or is otherwise...

  8. 29 CFR 1926.652 - Requirements for protective systems.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... no indication of a potential cave-in. (2) Protective systems shall have the capacity to resist without failure all loads that are intended or could reasonably be expected to be applied or transmitted... person cannot assure the material or equipment is able to support the intended loads or is otherwise...

  9. 29 CFR 1926.652 - Requirements for protective systems.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... no indication of a potential cave-in. (2) Protective systems shall have the capacity to resist without failure all loads that are intended or could reasonably be expected to be applied or transmitted... person cannot assure the material or equipment is able to support the intended loads or is otherwise...

  10. 29 CFR 1926.652 - Requirements for protective systems.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... no indication of a potential cave-in. (2) Protective systems shall have the capacity to resist without failure all loads that are intended or could reasonably be expected to be applied or transmitted... person cannot assure the material or equipment is able to support the intended loads or is otherwise...

  11. 29 CFR 1926.652 - Requirements for protective systems.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... no indication of a potential cave-in. (2) Protective systems shall have the capacity to resist without failure all loads that are intended or could reasonably be expected to be applied or transmitted... person cannot assure the material or equipment is able to support the intended loads or is otherwise...

  12. Thermal Management Coating As Thermal Protection System for Space Transportation System

    NASA Technical Reports Server (NTRS)

    Kaul, Raj; Stuckey, C. Irvin

    2003-01-01

    This paper presents viewgraphs on the development of a non-ablative thermal management coating used as the thermal protection system material for space shuttle rocket boosters and other launch vehicles. The topics include: 1) Coating Study; 2) Aerothermal Testing; 3) Preconditioning Environments; 4) Test Observations; 5) Lightning Strike Test Panel; 6) Test Panel After Impact Testing; 7) Thermal Testing; and 8) Mechanical Testing.

  13. Simultaneous approach using systemic, mucosal and transcutaneous routes of immunization for development of protective HIV-1 vaccines.

    PubMed

    Belyakov, I M; Ahlers, J D

    2011-01-01

    Mucosal tissues are major sites of HIV entry and initial infection. Induction of a local mucosal cytotoxic T lymphocyte response is considered an important goal in developing an effective HIV vaccine. In addition, activation and recruitment of memory CD4(+) and CD8(+) T cells in systemic lymphoid circulation to mucosal effector sites might provide the firewall needed to prevent virus spread. Therefore a vaccine that generates CD4(+) and CD8(+) responses in both mucosal and systemic tissues might be required for protection against HIV. However, optimal routes and number of vaccinations required for the generation of long lasting CD4(+) and CD8(+) CTL effector and memory responses are not well understood especially for mucosal T cells. A number of studies looking at protective immune responses against diverse mucosal pathogens have shown that mucosal vaccination is necessary to induce a compartmentalized immune response including maximum levels of mucosal high-avidity CD8(+) CTL, antigen specific mucosal antibodies titers (especially sIgA), as well as induction of innate anti-viral factors in mucosa tissue. Immune responses are detectable at mucosal sites after systemic delivery of vaccine, and prime boost regimens can amplify the magnitude of immune responses in mucosal sites and in systemic lymphoid tissues. We believe that the most optimal mucosal and systemic HIV/SIV specific protective immune responses and innate factors might best be achieved by simultaneous mucosal and systemic prime and boost vaccinations. Similar principals of vaccination may be applied for vaccine development against cancer and highly invasive pathogens that lead to chronic infection.

  14. SC79 protects retinal pigment epithelium cells from UV radiation via activating Akt-Nrf2 signaling

    PubMed Central

    Cao, Guo-fan; Cao, Cong; Jiang, Qin

    2016-01-01

    Excessive Ultra-violet (UV) radiation causes oxidative damages and apoptosis in retinal pigment epithelium (RPE) cells. Here we tested the potential activity of SC79, a novel small molecule activator of Akt, against the process. We showed that SC79 activated Akt in primary and established (ARPE-19 line) RPE cells. It protected RPE cells from UV damages possibly via inhibiting cell apoptosis. Akt inhibition, via an Akt specific inhibitor (MK-2206) or Akt1 shRNA silence, almost abolished SC79-induced RPE cytoprotection. Further studies showed that SC79 activated Akt-dependent NF-E2-related factor 2 (Nrf2) signaling and inhibited UV-induced oxidative stress in RPE cells. Reversely, Nrf2 shRNA knockdown or S40T mutation attenuated SC79-induced anti-UV activity. For the in vivo studies, we showed that intravitreal injection of SC79 significantly protected mouse retina from light damages. Based on these results, we suggest that SC79 protects RPE cells from UV damages possibly via activating Akt-Nrf2 signaling axis. PMID:27517753

  15. Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral ischemic injury

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jing, Xu; Ren, Dongmei; Wei, Xinbing

    Stroke is a complex disease that may involve oxidative stress-related pathways in its pathogenesis. The nuclear factor erythroid-2-related factor 2/antioxidant response element (Nrf2/ARE) pathway plays an important role in inducing phase II detoxifying enzymes and antioxidant proteins and thus has been considered a potential target for neuroprotection in stroke. The aim of the present study was to determine whether eriodictyol-7-O-glucoside (E7G), a novel Nrf2 activator, can protect against cerebral ischemic injury and to understand the role of the Nrf2/ARE pathway in neuroprotection. In primary cultured astrocytes, E7G increased the nuclear localization of Nrf2 and induced the expression of the Nrf2/ARE-dependentmore » genes. Exposure of astrocytes to E7G provided protection against oxygen and glucose deprivation (OGD)-induced oxidative insult. The protective effect of E7G was abolished by RNA interference-mediated knockdown of Nrf2 expression. In vivo administration of E7G in a rat model of focal cerebral ischemia significantly reduced the amount of brain damage and ameliorated neurological deficits. These data demonstrate that activation of Nrf2/ARE signaling by E7G is directly associated with its neuroprotection against oxidative stress-induced ischemic injury and suggest that targeting the Nrf2/ARE pathway may be a promising approach for therapeutic intervention in stroke. - Highlights: • E7G activates Nrf2 in astrocytes. • E7G stimulates expression of Nrf2-mediated cytoprotective proteins in astrocytes. • E7G protects astrocytes against OGD-induced cell death and apoptosis. • The neuroprotective effect of E7G involves the Nrf2/ARE pathway. • E7G protects rats against cerebral ischemic injury.« less

  16. Shell tile thermal protection system

    NASA Technical Reports Server (NTRS)

    Macconochie, I. O.; Lawson, A. G.; Kelly, H. N. (Inventor)

    1984-01-01

    A reusable, externally applied thermal protection system for use on aerospace vehicles subject to high thermal and mechanical stresses utilizes a shell tile structure which effectively separates its primary functions as an insulator and load absorber. The tile consists of structurally strong upper and lower metallic shells manufactured from materials meeting the thermal and structural requirements incident to tile placement on the spacecraft. A lightweight, high temperature package of insulation is utilized in the upper shell while a lightweight, low temperature insulation is utilized in the lower shell. Assembly of the tile which is facilitated by a self-locking mechanism, may occur subsequent to installation of the lower shell on the spacecraft structural skin.

  17. 78 FR 20004 - Protection of Stratospheric Ozone: Adjustments to the Allowance System for Controlling HCFC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-03

    ... Protection of Stratospheric Ozone: Adjustments to the Allowance System for Controlling HCFC Production... adjusting the allowance system controlling U.S. consumption and production of hydrochlorofluorocarbons... ``Protection of Stratospheric Ozone: Adjustments to the Allowance System for Controlling HCFC Production...

  18. Aerodynamic heating environment definition/thermal protection system selection for the HL-20

    NASA Astrophysics Data System (ADS)

    Wurster, K. E.; Stone, H. W.

    1993-09-01

    Definition of the aerothermal environment is critical to any vehicle such as the HL-20 Personnel Launch System that operates within the hypersonic flight regime. Selection of an appropriate thermal protection system design is highly dependent on the accuracy of the heating-environment prediction. It is demonstrated that the entry environment determines the thermal protection system design for this vehicle. The methods used to predict the thermal environment for the HL-20 Personnel Launch System vehicle are described. Comparisons of the engineering solutions with computational fluid dynamic predictions, as well as wind-tunnel test results, show good agreement. The aeroheating predictions over several critical regions of the vehicle, including the stagnation areas of the nose and leading edges, windward centerline and wing surfaces, and leeward surfaces, are discussed. Results of predictions based on the engineering methods found within the MINIVER aerodynamic heating code are used in conjunction with the results of the extensive wind-tunnel tests on this configuration to define a flight thermal environment. Finally, the selection of the thermal protection system based on these predictions and current technology is described.

  19. Rapid Activation of Nuclear Factor-κB by 17β-Estradiol and Selective Estrogen Receptor Modulators: Pathways Mediating Cellular Protection

    PubMed Central

    Stice, James P.; Mbai, Fiona N.; Chen, Le; Knowlton, Anne A.

    2012-01-01

    17β-estradiol (E2) treatment activates a set of protective response that have been found to protect cells from injury and more importantly to significantly abate the injuries associated with trauma-hemorrhage in vivo. Rapid NFκB activation has been found to be an important signaling step in E2 mediated protection in cell culture, in vivo ischemia and trauma-hemorrhage. In the current study, we investigated the signaling cascades linking E2 signaling with NFκB activation and the protective response, and compared them with the effects of two selective estrogen receptor modulators (SERMs), raloxifene and tamoxifen. Two candidate pathways, mitogen activated protein kinases (MAPK), and phosphatidylinositol-3-kinase (PI3-K) were studied. Selective inhibitors were used to identify each pathway's contribution to NFκB activation. Treatment of HCAECs with E2 activated PI3-K/Akt, p38, and JNK, all of which activated ERK 1/2 followed by NFκB activation. The combined activation of Akt, p38 and JNK was essential to activate NFκB. The two SERMs activated PI3-K and p38, which then phosphorylated ERK 1/2 and activated NFκB independent of the JNK pathway. NFkB activation by these compounds protected cells from hypoxia/reoxygenation injury. However, E2, unlike either SERM, led to modest increases in apoptosis through the JNK pathway. SERM treatment led to increased expression of the protective proteins, Mn-superoxide dismutase and endothelial nitric oxide synthase, that was not seen with E2. These results provide new insight into the pathways activating NFkB by E2 and SERMS and demonstrate that SERMs may have greater protective benefits than E2 in adult endothelial cells and potentially in vivo, as well. PMID:22683727

  20. The protective activity of tea against infection by Vibrio cholerae O1.

    PubMed

    Toda, M; Okubo, S; Ikigai, H; Suzuki, T; Suzuki, Y; Shimamura, T

    1991-02-01

    Extracts of black tea exhibited bactericidal activity against Vibrio cholerae O1. The tea extract inhibited the haemolysin activity of V. cholerae O1, El Tor and the morphological changes of Chinese hamster ovary cells induced by cholera toxin. Tea extract also reduced fluid accumulation induced by cholera toxin in sealed adult mice and by V. cholerae O1 in ligated intestinal loops of rabbits. These findings suggest that tea has protective activity against V. cholerae O1.

  1. The antiaging activity and cerebral protection of rapamycin at micro-doses.

    PubMed

    Qi, Haiyan; Su, Feng-Yun; Wan, Shan; Chen, Yongjie; Cheng, Yan-Qiong; Liu, Ai-Jun

    2014-11-01

    The immunosuppressant drug rapamycin was reported to have an antiaging activity, which was attributed to the TORC1 inhibition that inhibits cell proliferation and increases autophagy. However, rapamycin also exhibits a number of harmful adverse effects. Whether rapamycin can be developed into an antiaging agent remains unclear. We demonstrated that rapamycin at micro-doses (below the TORC1 inhibiting concentration) exhibits a cell-protective activity: (1) It protects cultured neurons against neurotoxin MPP(+) and H2O2. (2) It increases survival time of neuron in culture. (3) It maintains the nonproliferative state of cultured senescent human fibroblasts and prevents cell death induced by telomere dysfunction. (4) In animal models, it decreased the cerebral infarct sizes induced by acute ischemia and dramatically extended the life span of stroke prone spontaneously hypertensive rats (SHR-SPs). We propose that rapamycin at micro-dose can be developed into an antiaging agent with a novel mechanism. © 2014 John Wiley & Sons Ltd.

  2. 75 FR 22844 - Construction Fall Protection Systems Criteria and Practices and Training Requirements; Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ...] Construction Fall Protection Systems Criteria and Practices and Training Requirements; Extension of the Office of Management and Budget's (OMB) Approval of Information Collection (Paperwork) Requirements AGENCY... requirements contained in the construction standards on Fall Protection Systems Criteria and Practices (29 CFR...

  3. Curcumin protects neurons against oxygen-glucose deprivation/reoxygenation-induced injury through activation of peroxisome proliferator-activated receptor-γ function.

    PubMed

    Liu, Zun-Jing; Liu, Hong-Qiang; Xiao, Cheng; Fan, Hui-Zhen; Huang, Qing; Liu, Yun-Hai; Wang, Yu

    2014-11-01

    The turmeric derivative curcumin protects against cerebral ischemic injury. We previously demonstrated that curcumin activates peroxisome proliferator-activated receptor-γ (PPARγ), a ligand-activated transcription factor involved in both neuroprotective and anti-inflammatory signaling pathways. This study tested whether the neuroprotective effects of curcumin against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury of rat cortical neurons are mediated (at least in part) by PPARγ. Curcumin (10 μM) potently enhanced PPARγ expression and transcriptional activity following OGD/R. In addition, curcumin markedly increased neuronal viability, as evidenced by decreased lactate dehydrogenase release and reduced nitric oxide production, caspase-3 activity, and apoptosis. These protective effects were suppressed by coadministration of the PPARγ antagonist 2-chloro-5-nitrobenzanilide (GW9662) and by prior transfection of a small-interfering RNA (siRNA) targeting PPARγ, treatments that had no toxic effects on healthy neurons. Curcumin reduced OGD/R-induced accumulation of reactive oxygen species and inhibited the mitochondrial apoptosis pathway, as indicated by reduced release of cytochrome c and apoptosis-inducing factor and maintenance of both the mitochondrial membrane potential and the Bax/Bcl-2 ratio. Again, GW9662 or PPARγ siRNA transfection mitigated the protective effects of curcumin on mitochondrial function. Curcumin suppressed IκB kinase phosphorylation and IκB degradation, thereby inhibiting nuclear factor-κ B (NF-κB) nuclear translocation, effects also blocked by GW9662 or PPARγ siRNA. Immunoprecipitation experiments revealed that PPARγ interacted with NF-κB p65 and inhibited NF-κB activation. The present study provides strong evidence that at least some of the neuroprotective effects of curcumin against OGD/R are mediated by PPARγ activation. Copyright © 2014 Wiley Periodicals, Inc.

  4. Subunit Rotavirus Vaccine Administered Parenterally to Rabbits Induces Active Protective Immunity

    PubMed Central

    Ciarlet, Max; Crawford, Sue E.; Barone, Christopher; Bertolotti-Ciarlet, Andrea; Ramig, Robert F.; Estes, Mary K.; Conner, Margaret E.

    1998-01-01

    Virus-like particles (VLPs) are being evaluated as a candidate rotavirus vaccine. The immunogenicity and protective efficacy of different formulations of VLPs administered parenterally to rabbits were tested. Two doses of VLPs (2/6-, G3 2/6/7-, or P[2], G3 2/4/6/7-VLPs) or SA11 simian rotavirus in Freund’s adjuvants, QS-21 (saponin adjuvant), or aluminum phosphate (AlP) were administered. Serological and mucosal immune responses were evaluated in all vaccinated and control rabbits before and after oral challenge with 103 50% infective doses of live P[14], G3 ALA lapine rotavirus. All VLP- and SA11-vaccinated rabbits developed high levels of rotavirus-specific serum and intestinal immunoglobulin G (IgG) antibodies but not intestinal IgA antibodies. SA11 and 2/4/6/7-VLPs afforded similar but much higher mean levels of protection than 2/6/7- or 2/6-VLPs in QS-21. The presence of neutralizing antibodies to VP4 correlated (P < 0.001, r = 0.55; Pearson’s correlation coefficient) with enhanced protection rates, suggesting that these antibodies are important for protection. Although the inclusion of VP4 resulted in higher mean protection levels, high levels of protection (87 to 100%) from infection were observed in individual rabbits immunized with 2/6/7- or 2/6-VLPs in Freund’s adjuvants. Therefore, neither VP7 nor VP4 was absolutely required to achieve protection from infection in the rabbit model when Freund’s adjuvant was used. Our results show that VLPs are immunogenic when administered parenterally to rabbits and that Freund’s adjuvant is a better adjuvant than QS-21. The use of the rabbit model may help further our understanding of the critical rotavirus proteins needed to induce active protection. VLPs are a promising candidate for a parenterally administered subunit rotavirus vaccine. PMID:9765471

  5. Protective and Pathological Immunity during Central Nervous System Infections.

    PubMed

    Klein, Robyn S; Hunter, Christopher A

    2017-06-20

    The concept of immune privilege of the central nervous system (CNS) has dominated the study of inflammatory processes in the brain. However, clinically relevant models have highlighted that innate pathways limit pathogen invasion of the CNS and adaptive immunity mediates control of many neural infections. As protective responses can result in bystander damage, there are regulatory mechanisms that balance protective and pathological inflammation, but these mechanisms might also allow microbial persistence. The focus of this review is to consider the host-pathogen interactions that influence neurotropic infections and to highlight advances in our understanding of innate and adaptive mechanisms of resistance as key determinants of the outcome of CNS infection. Advances in these areas have broadened our comprehension of how the immune system functions in the brain and can readily overcome immune privilege. Copyright © 2017. Published by Elsevier Inc.

  6. Transmission system protection screening for integration of offshore wind power plants

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sajadi, A.; Strezoski, L.; Clark, K.

    This paper develops an efficient methodology for protection screening of large-scale transmission systems as part of the planning studies for the integration of offshore wind power plants into the power grid. This methodology avails to determine whether any upgrades are required to the protection system. The uncertainty is considered in form of variability of the power generation by offshore wind power plant. This paper uses the integration of a 1000 MW offshore wind power plant operating in Lake Erie into the FirstEnergy/PJM service territory as a case study. This study uses a realistic model of a 63,000-bus test system thatmore » represents the U.S. Eastern Interconnection.« less

  7. Transmission system protection screening for integration of offshore wind power plants

    DOE PAGES

    Sajadi, A.; Strezoski, L.; Clark, K.; ...

    2018-02-21

    This paper develops an efficient methodology for protection screening of large-scale transmission systems as part of the planning studies for the integration of offshore wind power plants into the power grid. This methodology avails to determine whether any upgrades are required to the protection system. The uncertainty is considered in form of variability of the power generation by offshore wind power plant. This paper uses the integration of a 1000 MW offshore wind power plant operating in Lake Erie into the FirstEnergy/PJM service territory as a case study. This study uses a realistic model of a 63,000-bus test system thatmore » represents the U.S. Eastern Interconnection.« less

  8. Risk Based Reliability Centered Maintenance of DOD Fire Protection Systems

    DTIC Science & Technology

    1999-01-01

    2.2.3 Failure Mode and Effect Analysis ( FMEA )............................ 2.2.4 Failure Mode Risk Characterization...Step 2 - System functions and functional failures definition Step 3 - Failure mode and effect analysis ( FMEA ) Step 4 - Failure mode risk...system). The Interface Location column identifies the location where the FMEA of the fire protection system began or stopped. For example, for the fire

  9. Promoting and Protecting Public Health: How the European Union Pharmacovigilance System Works.

    PubMed

    Santoro, Aniello; Genov, Georgy; Spooner, Almath; Raine, June; Arlett, Peter

    2017-10-01

    This article provides an overview of the European Union pharmacovigilance system resulting from the rationalisation and strengthening delivered through the implementation of the revised pharmacovigilance legislation. It outlines the system aims, underlying principles, components and drivers for future change. At its core, the Pharmacovigilance Risk Assessment Committee is responsible for assessing all aspects of the risk management of medicinal products, thus ensuring that medicines approved for the European Union market are optimally used by maximising their benefits and minimising risks. The main objectives of the system are to promote and protect public health by supporting the availability of medicines including those that fulfil previously unmet medical needs, and reducing the burden of adverse drug reactions. These are achieved through a proactive, risk proportionate and patient-centred approach, with high levels of transparency and engagement of civil society. In the European Union, pharmacovigilance is now fully integrated into the life cycle of medicinal products, with the planning of pharmacovigilance activities commencing before a medicine is placed on the market, and companies encouraged to start planning very early in development for high-innovation products. After authorisation, information on the safety of medicines continues to be obtained through a variety of sources, including spontaneous reports of adverse drug reactions or monitoring real-world data. Finally, the measurement of the impact of pharmacovigilance activities, auditing and inspections, as well as capacity building ensure that the system undergoes continuous improvement and can always rely on the best methodologies to safeguard public health.

  10. Evaluation of Cathodic Protection Systems for Marine Bridge Substructures

    DOT National Transportation Integrated Search

    1998-12-01

    Four different cathodic protection systems were installed and evaluated in the reinforced concrete tie beams and footings of four bents at the Queen Isabella Causeway which links South Padre Island to the mainland of Texas. The types of cathodic prot...

  11. How can the auditory efferent system protect our ears from noise-induced hearing loss? Let us count the ways

    NASA Astrophysics Data System (ADS)

    Marshall, Lynne; Miller, Judi A. Lapsley

    2015-12-01

    It is a cause for some debate as to how the auditory olivocochlear (OC) efferent system could protect hearing from noise trauma. In this review, we examined physiological research to find mechanisms that could effectively attenuate the response to sound. For each purported mechanism, we indicate which part of the OC-efferent system is responsible for the function and the site of action. These mechanisms include basilar-membrane phase shifts at high stimulus levels; changes in outer-hair-cell stiffness and phase lag associated with efferent slow effects; small decreases in endocochlear potentials causing small decreases in outer- and inner-hair-cell output; low-spontaneous-rate and medium-spontaneous-rate fibers showing OC-induced decrements at high levels; auditory-nerve initial-peak reduction; OC effect increasing over minutes; cholinergic activation of anti-apoptotic pathways; and anti-excitotoxicity. There are clearly multiple opportunities for the OC-efferent system to protect the inner ear from noise trauma. From further exploration into the mechanisms outlined here, as well as to-be-discovered mechanisms, we will gain a greater understanding of the protective nature of the OC-efferent system. These findings could aid our ability to design better predictive tests for people at risk for noise-induced hearing loss.

  12. openEHR Based Systems and the General Data Protection Regulation (GDPR).

    PubMed

    Sousa, Mariana; Ferreira, Duarte; Santos-Pereira, Cátia; Bacelar, Gustavo; Frade, Samuel; Pestana, Olívia; Cruz-Correia, Ricardo

    2018-01-01

    The concerns about privacy and personal data protection resulted in reforms of the existing legislation in European Union (EU). The General Data Protection Regulation (GDPR) aims to reform the existing measures on the topic of personal data protection of the European Union citizens, with a strong input on the rights and freedoms of people and in the establishment of rules for the processing of personal data. OpenEHR is a standard that embodies many principles of interoperable and secure software for electronic health records. This work aims to understand to what extent the openEHR standard can be considered a solution for the requirements needed by GDPR. A list of requirements for a Hospital Information Systems (HIS) compliant with GDPR and an identification of openEHR specifications was made. The requirements were categorized and compared with the specifications. The requirements identified for the systems were matched with the openEHR specifications, which result in 16 requirements matched with openEHR. All the specifications identified matched at least one requirement. OpenEHR is a solution for the development of HIS that reinforce privacy and personal data protection, ensuring that they are contemplated in the system development. The institutions can secure that their Eletronic Health Record are compliant with GDPR while safeguarding the medical data quality and, as a result, the healthcare delivery.

  13. Protective effect and relation structure-activity of nonivamide and iododerivatives in several models of lipid oxidation.

    PubMed

    Rosa, Antonella; Appendino, Giovanni; Melis, M Paola; Deiana, Monica; Atzeri, Angela; Alessandra, Incani; Minassi, Alberto; Dessì, M Assunta

    2009-07-15

    The introduction of an iodine atom on the vanillyl moiety of nonivamide causes a switch in the vanilloid activity (TRPV1 antagonism versus TRPV1 desensitization) and nullifies the aversive properties of capsaicinoids. In the present study we investigated the effect of iodination in the vanillyl moiety on the antioxidant activity of capsaicinoids. To this aim, we have compared the protective effects of nonivamide and three iododerivatives, 2-iodononivamide (2IN), 5-iodononivamide (5IN), and 6-iodononivamide (6IN) in a series of in vitro models of lipid oxidation, namely the autoxidation and the FeCl(3)-mediated oxidation of linoleic acid at 37 degrees C and the thermal (140 degrees C), solvent-free oxidation of cholesterol. All tested compounds could protect linoleic acid and cholesterol against oxidative degradation, the order of potency being: nonivamide>5IN>6IN approximately 2IN. Our results show that, in general, the introduction of an iodine atom on the vanillyl moiety of nonivamide causes a decrease in the antioxidant activity, and this effect is sensitive to the position of iodine on the aromatic ring, with 5IN substantially retaining the efficacy of nonivamide to protect linoleic and cholesterol against free radical attack. Moreover, the pre-treatment with 5IN, at noncytotoxic concentrations, significantly preserved LDL from Cu(2+)-induced oxidative damage at 37 degrees C for 2h, inhibiting the reduction of polyunsaturated fatty acids and cholesterol and the increase of their oxidative products. The results of the present work suggest that 5IN exerts useful antioxidant properties in different in vitro systems of lipid peroxidation. This, coupled to its lacks of pungency and TRPV1 inhibiting properties, qualifies this phenolic compound as an attractive candidate for further investigations in vivo.

  14. Ex vivo model of meningococcal bacteremia using human blood for measuring vaccine-induced serum passive protective activity.

    PubMed

    Plested, Joyce S; Welsch, Jo Anne; Granoff, Dan M

    2009-06-01

    The binding of complement factor H (fH) to meningococci was recently found to be specific for human fH. Therefore, passive protective antibody activity measured in animal models of meningococcal bacteremia may overestimate protection in humans, since in the absence of bound fH, complement activation is not downregulated. We developed an ex vivo model of meningococcal bacteremia using nonimmune human blood to measure the passive protective activity of stored sera from 36 adults who had been immunized with an investigational meningococcal multicomponent recombinant protein vaccine. Before immunization, human complement-mediated serum bactericidal activity (SBA) titers of > or = 1:4 against group B strains H44/76, NZ98/254, and S3032 were present in 19, 11, and 8% of subjects, respectively; these proportions increased to 97, 22, and 36%, respectively, 1 month after dose 3 (P < 0.01 for H44/76 and S3032). Against the two SBA-resistant strains, NZ98/254 and S3032, passive protective titers of > or = 1:4 were present in 11 and 42% of sera before immunization, respectively, and these proportions increased to 61 and 94% after immunization (P < 0.001 for each strain). Most of the sera with SBA titers of <1:4 and passive protective activity showed a level of killing in the whole-blood assay (>1 to 2 log(10) decreases in CFU/ml during a 90-min incubation) similar to that of sera with SBA titers of > or = 1:4. In conclusion, passive protective activity was 2.6- to 2.8-fold more frequent than SBA after immunization. The ability of SBA-negative sera to kill Neisseria meningitidis in human blood where fH is bound to the bacteria provides further evidence that SBA titers of > or = 1:4 measured with human complement may underestimate meningococcal immunity.

  15. Lightning protection system for a wind turbine

    DOEpatents

    Costin, Daniel P [Chelsea, VT; Petter, Jeffrey K [Williston, VT

    2008-05-27

    In a wind turbine (104, 500, 704) having a plurality of blades (132, 404, 516, 744) and a blade rotor hub (120, 712), a lightning protection system (100, 504, 700) for conducting lightning strikes to any one of the blades and the region surrounding the blade hub along a path around the blade hub and critical components of the wind turbine, such as the generator (112, 716), gearbox (708) and main turbine bearings (176, 724).

  16. Skin-resident CD4+ T cells protect against Leishmania major by recruiting and activating inflammatory monocytes

    PubMed Central

    Glennie, Nelson D.; Volk, Susan W.

    2017-01-01

    Tissue-resident memory T cells are required for establishing protective immunity against a variety of different pathogens, although the mechanisms mediating protection by CD4+ resident memory T cells are still being defined. In this study we addressed this issue with a population of protective skin-resident, IFNγ-producing CD4+ memory T cells generated following Leishmania major infection. We previously found that resident memory T cells recruit circulating effector T cells to enhance immunity. Here we show that resident memory CD4+ T cells mediate the delayed-hypersensitivity response observed in immune mice and provide protection without circulating T cells. This protection occurs rapidly after challenge, and requires the recruitment and activation of inflammatory monocytes, which limit parasites by production of both reactive oxygen species and nitric oxide. Overall, these data highlight a novel role for tissue-resident memory cells in recruiting and activating inflammatory monocytes, and underscore the central role that skin-resident T cells play in immunity to cutaneous leishmaniasis. PMID:28419151

  17. Application of Advanced Wide Area Early Warning Systems with Adaptive Protection

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Blumstein, Carl; Cibulka, Lloyd; Thorp, James

    2014-09-30

    Recent blackouts of power systems in North America and throughout the world have shown how critical a reliable power system is to modern societies, and the enormous economic and societal damage a blackout can cause. It has been noted that unanticipated operation of protection systems can contribute to cascading phenomena and, ultimately, blackouts. This project developed and field-tested two methods of Adaptive Protection systems utilizing synchrophasor data. One method detects conditions of system stress that can lead to unintended relay operation, and initiates a supervisory signal to modify relay response in real time to avoid false trips. The second methodmore » detects the possibility of false trips of impedance relays as stable system swings “encroach” on the relays’ impedance zones, and produces an early warning so that relay engineers can re-evaluate relay settings. In addition, real-time synchrophasor data produced by this project was used to develop advanced visualization techniques for display of synchrophasor data to utility operators and engineers.« less

  18. Protective activity of Lentinan in experimental tuberculosis.

    PubMed

    Markova, Nadya; Kussovski, Vesselin; Drandarska, Ivanka; Nikolaeva, Sascha; Georgieva, Neli; Radoucheva, Tatyana

    2003-10-01

    Protective effects of Lentinan (Ajinomoto, Japan) against Mycobacterium tuberculosis infection were studied by in vitro and in vivo mouse models. The effectiveness of Lentinan administrated intraperitoneally (i.p.) before infection at a dose of 1 mg/kg three times at 2-day intervals was monitored in vivo by several parameters (body temperature; spleen weight; CFU counts of M. tuberculosis in spleen, liver and lung; and histomorphological observations). Peritoneal macrophages obtained from animals treated with Lentinan were greatly stimulated, as assayed by establishing their number, acid phosphatase activity, H2O2 production and killing ability against M. tuberculosis in vitro. The in vivo model demonstrated that administration of Lentinan before infection can mobilize host defense potential and reduce mycobacterial infection.

  19. Microbial ecology of terrestrial Antarctica: Are microbial systems at risk from human activities?

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    White, G.J.

    1996-08-01

    Many of the ecological systems found in continental Antarctica are comprised entirely of microbial species. Concerns have arisen that these microbial systems might be at risk either directly through the actions of humans or indirectly through increased competition from introduced species. Although protection of native biota is covered by the Protocol on Environmental Protection to the Antarctic Treaty, strict measures for preventing the introduction on non-native species or for protecting microbial habitats may be impractical. This report summarizes the research conducted to date on microbial ecosystems in continental Antarctica and discusses the need for protecting these ecosystems. The focus ismore » on communities inhabiting soil and rock surfaces in non-coastal areas of continental Antarctica. Although current polices regarding waste management and other operations in Antarctic research stations serve to reduce the introduction on non- native microbial species, importation cannot be eliminated entirely. Increased awareness of microbial habitats by field personnel and protection of certain unique habitats from physical destruction by humans may be necessary. At present, small-scale impacts from human activities are occurring in certain areas both in terms of introduced species and destruction of habitat. On a large scale, however, it is questionable whether the introduction of non-native microbial species to terrestrial Antarctica merits concern.« less

  20. Automated enclosure and protection system for compact solar-tracking spectrometers

    NASA Astrophysics Data System (ADS)

    Heinle, Ludwig; Chen, Jia

    2018-04-01

    A novel automated enclosure for protecting solar-tracking atmospheric instruments was designed, constructed, and successfully tested under various weather conditions. A complete automated measurement system, consisting of a compact solar-tracking Fourier transform infrared (FTIR) spectrometer (EM27/SUN) and the enclosure, has been deployed in central Munich to monitor greenhouse gases since 2016 and withstood all critical weather conditions, including rain, storms, and snow. It provided ground-based measurements of column-averaged concentrations of CO2, CH4, O2, and H2O throughout this time.The enclosure protects the instrument from harmful environmental influences while allowing open-path measurements in sunny weather. The newly developed and patented cover, a key component of the enclosure, permits unblocked solar measurements while reliably protecting the instrument. This enables dynamic decision regarding taking measurements, and thus increases the number of data samples. This enclosure leads to a fully automated measurement system, which collects data whenever possible without any human interaction. In the long term, the enclosure will provide the foundation for a permanent greenhouse gas monitoring sensor network.

  1. Antibacterial Activity of Hawaiian Corals: Possible Protection from Disease?

    NASA Astrophysics Data System (ADS)

    Gochfeld, D. J.; Aeby, G. S.; Miller, J. D.

    2006-12-01

    Reports of coral diseases in the Caribbean have appeared with increasing frequency over the past two decades; however, records of coral diseases in the Pacific have lagged far behind. Recent surveys of coral disease in the Hawaiian Islands indicate relatively low, but consistent, levels of disease throughout the inhabited Main and uninhabited Northwestern Hawaiian Islands, and demonstrate variation in levels of disease among the major genera of Hawaiian corals. Although little is known about immune defense to disease in corals, one potential mechanism of defense is the production of antimicrobial compounds that protect corals from pathogens. A preliminary survey of antibacterial chemical defenses among three dominant species of Hawaiian corals was undertaken. Crude aqueous extracts of Porites lobata, Pocillopora meandrina and Montipora capitata were tested against nine strains of bacteria in a growth inhibition assay. Inhibitory extracts were further tested to determine whether their effects were cytostatic or cytotoxic. The bacteria selected included known coral pathogens, potential marine pathogens found in human waste and strains previously identified from the surfaces of Hawaiian corals. Extracts from all three species of coral exhibited a high degree of antibacterial activity, but also a high degree of selectivity against different bacterial strains. In addition, some extracts were stimulatory to some bacteria. In addition to interspecific variability, extracts also exhibited intraspecific variability, both within and between sites. Hawaiian corals have significant antibacterial activity, which may explain the relatively low prevalence of disease in these corals; however, further characterization of pathogens specifically responsible for disease in Hawaiian corals is necessary before we can conclude that antibacterial activity protects Hawaiian corals from disease.

  2. Intermetallics for Thermal Protection Systems

    NASA Astrophysics Data System (ADS)

    Marcos, J.

    2009-01-01

    Future Reusable Launch Vehicles (RLV's) will require improved Thermal Protection Systems (TPS) to achieve the ambitious goal of reducing the cost of delivering a payload to orbit by, at least, an order of magnitude. In this context, metallic materials are good candidates for their use in TPS and hot structures. Up to date, only two major type of materials have been considered and developed in Europe for such type of applications: Oxide Dispersion Strengthened (ODS) and intermetallics (ϒ-TiAl). INASMET, during last years, has been working with the orthorhombic titanium aluminides, whose specific properties are comparable, to those of ODS and ϒ-TiAl materials. The EXPERT mission represents a unique opportunity to test under re-entry conditions this material.

  3. Protective Effect of Active Immunization with Purified Escherichia coli Heat-Labile Enterotoxin in Rats

    PubMed Central

    Klipstein, Frederick A.; Engert, Richard F.

    1979-01-01

    The protective effect of active immunization by different routes with a purified preparation of the polymyxin-release form of Escherichia coli heat-labile toxin was evaluated in rats. Immunized animals were challenged by placing toxin into ligated ileal loops at dosages which produced either 50% or the maximum secretory response in unimmunized rats. Immunization exclusively by the parenteral route yielded significant protection. Rats were also protected when parenteral priming was followed by boosting given either directly into the duodenum or perorally 2 h after intragastric cimetidine, but not when the peroral boosts were given with bicarbonate. Immunization administered entirely by the peroral route with cimetidine yielded protection but only when the immunizing dosage was fivefold greater than that found effective in the parenteral-peroral approach. Rats immunized exclusively by the parenteral route and those boosted perorally with cimetidine were also tested, and found to be protected, against challenge with viable organisms of strains that produce either heat-labile toxin alone or both heat-labile and heat-stable toxin, but they were not protected against a strain which produces just heat-stable toxin. Geometric mean serum antibody titers were increased by 16-fold or more over control values in those groups of rats in which protection was achieved, with the exception of those immunized exclusively by the peroral route. These observations demonstrate that (i) active immunization with purified E. coli heat-labile toxin results in significant protection against both this toxin as well as viable organisms which produce it, but not against viable strains which produce heat-stable toxin only, and (ii) concomitant ablation of gastric secretion by the use of cimetidine renders the peroral route of immunization effective. They suggest that prophylactic immunization against diarrheal disease caused by heat-labile toxin-producing strains of E. coli may be feasible in

  4. 33 CFR 149.418 - What fire protection system must a helicopter fueling facility have?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... a helicopter fueling facility have? 149.418 Section 149.418 Navigation and Navigable Waters COAST... protection system must a helicopter fueling facility have? In addition to the portable fire extinguishers required under table 149.409, each helicopter fueling facility must have a fire protection system complying...

  5. 33 CFR 149.418 - What fire protection system must a helicopter fueling facility have?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... a helicopter fueling facility have? 149.418 Section 149.418 Navigation and Navigable Waters COAST... protection system must a helicopter fueling facility have? In addition to the portable fire extinguishers required under table 149.409, each helicopter fueling facility must have a fire protection system complying...

  6. 33 CFR 149.418 - What fire protection system must a helicopter fueling facility have?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... a helicopter fueling facility have? 149.418 Section 149.418 Navigation and Navigable Waters COAST... protection system must a helicopter fueling facility have? In addition to the portable fire extinguishers required under table 149.409, each helicopter fueling facility must have a fire protection system complying...

  7. From Civil Protection Plan to Disaster Management. PETer evolution from GIS tool to multi-area Emergency Management System

    NASA Astrophysics Data System (ADS)

    Frigerio, Simone; Sterlacchini, Simone; Malet, Jean-Philippe; Glade, Thomas

    2010-05-01

    PETer (Protection and Emergency of the Territory) has been developed since 2006 as a tool to manage all the information available to perform a wide range of Civil Protection activities. Based on MapObjects spatial support, it was relied on capacity to manage data from different sources and at different scale, offering practical GIS-tools for a technical and practical use during crisis state. At the first stages of the development, after different assessment, critical on-field analysis and a direct proof on test area, the approach came into sight like a valid database management for the entire dataset, but quite static, not full-blown for every emergency necessity, too complicate and not enough user-friendly, considering people in charge during emergency management, the quick change of state with many parameters involved and also uncertainty, hesitation, confusion or general panic among decision makers. As a second step of research, a more down-to-earth methodology targeted to cope with the aftermath of critical events is presented here. It takes advantage of Geographical Information Systems (GIS), Decision Support Systems (DSS), and Information and Communication Technology (ICT) to prepare, apply and coordinate Civil Protection plans. The main aim was to set up and manage contingency plans in advance; that is, to identify and prepare people in charge to take action to define the activities to be performed, to be aware of available resources and to optimize the communication system among the people involved, in order to efficiently face a prospective crisis phase. A disaster preparedness plan should anticipate the demands for a disaster relief operation and indicate the most effective way of joining those requirements. Through scientific and technical co-operation between public and private research groups, a new platform was planned and set up, in order to test the aims of the project. The application was based on a cooperative organizational structure by which

  8. Programming microphysiological systems for children's health protection (SEBM meeting)

    EPA Science Inventory

    Presentation: Programming microphysiological systems for children’s health protectionAuthors: Knudsen1 T, Klieforth2 B, and Slikker3 W Jr.1National Center for Computational Toxicology/EPA, Research Triangle Park NC2National Center for Environmental Research/EPA, Washington DC3Nat...

  9. Representation of Ecological Systems within the Protected Areas Network of the Continental United States

    PubMed Central

    Aycrigg, Jocelyn L.; Davidson, Anne; Svancara, Leona K.; Gergely, Kevin J.; McKerrow, Alexa; Scott, J. Michael

    2013-01-01

    If conservation of biodiversity is the goal, then the protected areas network of the continental US may be one of our best conservation tools for safeguarding ecological systems (i.e., vegetation communities). We evaluated representation of ecological systems in the current protected areas network and found insufficient representation at three vegetation community levels within lower elevations and moderate to high productivity soils. We used national-level data for ecological systems and a protected areas database to explore alternative ways we might be able to increase representation of ecological systems within the continental US. By following one or more of these alternatives it may be possible to increase the representation of ecological systems in the protected areas network both quantitatively (from 10% up to 39%) and geographically and come closer to meeting the suggested Convention on Biological Diversity target of 17% for terrestrial areas. We used the Landscape Conservation Cooperative framework for regional analysis and found that increased conservation on some private and public lands may be important to the conservation of ecological systems in Western US, while increased public-private partnerships may be important in the conservation of ecological systems in Eastern US. We have not assessed the pros and cons of following the national or regional alternatives, but rather present them as possibilities that may be considered and evaluated as decisions are made to increase the representation of ecological systems in the protected areas network across their range of ecological, geographical, and geophysical occurrence in the continental US into the future. PMID:23372754

  10. Representation of ecological systems within the protected areas network of the continental United States

    USGS Publications Warehouse

    Aycrigg, Jocelyn L.; Davidson, Anne; Svancara, Leona K.; Gergely, Kevin J.; McKerrow, Alexa; Scott, J. Michael

    2013-01-01

    If conservation of biodiversity is the goal, then the protected areas network of the continental US may be one of our best conservation tools for safeguarding ecological systems (i.e., vegetation communities). We evaluated representation of ecological systems in the current protected areas network and found insufficient representation at three vegetation community levels within lower elevations and moderate to high productivity soils. We used national-level data for ecological systems and a protected areas database to explore alternative ways we might be able to increase representation of ecological systems within the continental US. By following one or more of these alternatives it may be possible to increase the representation of ecological systems in the protected areas network both quantitatively (from 10% up to 39%) and geographically and come closer to meeting the suggested Convention on Biological Diversity target of 17% for terrestrial areas. We used the Landscape Conservation Cooperative framework for regional analysis and found that increased conservation on some private and public lands may be important to the conservation of ecological systems in Western US, while increased public-private partnerships may be important in the conservation of ecological systems in Eastern US. We have not assessed the pros and cons of following the national or regional alternatives, but rather present them as possibilities that may be considered and evaluated as decisions are made to increase the representation of ecological systems in the protected areas network across their range of ecological, geographical, and geophysical occurrence in the continental US into the future.

  11. TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis.

    PubMed

    Francisco, Ngiambudulu M; Hsu, Nai-Jen; Keeton, Roanne; Randall, Philippa; Sebesho, Boipelo; Allie, Nasiema; Govender, Dhirendra; Quesniaux, Valerie; Ryffel, Bernhard; Kellaway, Lauriston; Jacobs, Muazzam

    2015-06-26

    Tuberculosis (TB) affects one third of the global population, and TB of the central nervous system (CNS-TB) is the most severe form of tuberculosis which often associates with high mortality. The pro-inflammatory cytokine tumour necrosis factor (TNF) plays a critical role in the initial and long-term host immune protection against Mycobacterium tuberculosis (M. tuberculosis) which involves the activation of innate immune cells and structure maintenance of granulomas. However, the contribution of TNF, in particular neuron-derived TNF, in the control of cerebral M. tuberculosis infection and its protective immune responses in the CNS were not clear. We generated neuron-specific TNF-deficient (NsTNF(-/-)) mice and compared outcomes of disease against TNF(f/f) control and global TNF(-/-) mice. Mycobacterial burden in brains, lungs and spleens were compared, and cerebral pathology and cellular contributions analysed by microscopy and flow cytometry after M. tuberculosis infection. Activation of innate immune cells was measured by flow cytometry and cell function assessed by cytokine and chemokine quantification using enzyme-linked immunosorbent assay (ELISA). Intracerebral M. tuberculosis infection of TNF(-/-) mice rendered animals highly susceptible, accompanied by uncontrolled bacilli replication and eventual mortality. In contrast, NsTNF(-/-) mice were resistant to infection and presented with a phenotype similar to that in TNF(f/f) control mice. Impaired immunity in TNF(-/-) mice was associated with altered cytokine and chemokine synthesis in the brain and characterised by a reduced number of activated innate immune cells. Brain pathology reflected enhanced inflammation dominated by neutrophil influx. Our data show that neuron-derived TNF has a limited role in immune responses, but overall TNF production is necessary for protective immunity against CNS-TB.

  12. Overload protection system

    NASA Technical Reports Server (NTRS)

    Nagano, S.

    1979-01-01

    Overload protection circuit utilizes one circuit for suspending inverter action when load abnormality is detected and second circuit to monitor clearance of abnormality. Device wastes no power during normal operating conditions and responds instantaneously when abnormality is cleared.

  13. Whistleblower Protection

    EPA Pesticide Factsheets

    The Whistleblower Protection Enhancement Act of 2012 (WPA) and the Whistleblower Protection Act of 1989 Enhanced by the Act of 2012 provides protection rights for Federal employees against retaliation for whistleblowing activities.

  14. An Assessment of Alternate Thermal Protection Systems for the Space Shuttle Orbiter. Volume 1; Executive Summary

    NASA Technical Reports Server (NTRS)

    Hays, D.

    1982-01-01

    Alternate thermal protection system (TPS) concepts to the Space Shuttle Orbiter were assessed. Metallic, ablator, and carbon-carbon concepts which are the result of some previous design, manufacturing and testing effort were considered. Emphasis was placed on improved TPS durability, which could potentially reduce life cycle costs and improve Orbiter operational characteristics. Integrated concept/orbiter point designs were generated and analyzed on the basis of Shuttle design environments and criteria. A merit function evaluation methodology based on mission impact, life cycle costs, and risk was developed to compare the candidate concepts and to identify the best alternate. Voids and deficiencies in the technology were identified, along with recommended activities to overcome them. Finally, programmatic plans, including ROM costs and schedules, were developed for all activities required to bring the selected alternate system up to operational readiness.

  15. Altitude Effects on Thermal Ice Protection System Performance; A Study of an Alternative Simulation Approach

    NASA Technical Reports Server (NTRS)

    Addy, Gene; Wright, Bill; Orchard, David; Oleskiw, Myron

    2015-01-01

    The quest for more energy-efficient green aircraft, dictates that all systems, including the ice protection system (IPS), be closely examined for ways to reduce energy consumption and to increase efficiency. A thermal ice protection systems must protect the aircraft from the hazardous effects of icing, and yet it needs to do so as efficiently as possible. The system can no longer be afforded the degree of over-design in power usage they once were. To achieve these more exacting designs, a better understanding of the heat and mass transport phenomena involved during an icing encounter is needed.

  16. A Federal Response: The President's Critical Infrastructure Protection Board.

    ERIC Educational Resources Information Center

    Schmidt, Howard

    2002-01-01

    Outlines the U.S. Critical Infrastructure Protection Board's purpose, budget, principles, and priorities. Describes the board's role in coordinating all federal activities related to protection of information systems and networks supporting critical infrastructures. Also discusses its responsibility in creating a policy and road map for government…

  17. Flexible Thermal Protection System Development for Hypersonic Inflatable Aerodynamic Decelerators

    NASA Technical Reports Server (NTRS)

    DelCorso, Joseph A.; Bruce, Walter E., III; Hughes, Stephen J.; Dec, John A.; Rezin, Marc D.; Meador, Mary Ann B.; Guo, Haiquan; Fletcher, Douglas G.; Calomino, Anthony M.; Cheatwood, McNeil

    2012-01-01

    The Hypersonic Inflatable Aerodynamic Decelerators (HIAD) project has invested in development of multiple thermal protection system (TPS) candidates to be used in inflatable, high downmass, technology flight projects. Flexible TPS is one element of the HIAD project which is tasked with the research and development of the technology ranging from direct ground tests, modelling and simulation, characterization of TPS systems, manufacturing and handling, and standards and policy definition. The intent of flexible TPS is to enable large deployable aeroshell technologies, which increase the drag performance while significantly reducing the ballistic coefficient of high-mass entry vehicles. A HIAD requires a flexible TPS capable of surviving aerothermal loads, and durable enough to survive the rigors of construction, handling, high density packing, long duration exposure to extrinsic, in-situ environments, and deployment. This paper provides a comprehensive overview of key work being performed within the Flexible TPS element of the HIAD project. Included in this paper is an overview of, and results from, each Flexible TPS research and development activity, which includes ground testing, physics-based thermal modelling, age testing, margins policy, catalysis, materials characterization, and recent developments with new TPS materials.

  18. Defence force activities in marine protected areas: environmental management of Shoalwater Bay Training Area, Queensland, Australia

    NASA Astrophysics Data System (ADS)

    Wu, Wen; Wang, Xiaohua; Paull, David; Kesby, Julie

    2010-05-01

    Environmental management of military activities is of growing global concern by defence forces. As one of the largest landholders in Australia, the Australian Defence Force (ADF) is increasingly concerned with sustainable environmental management. This paper focuses on how the ADF is maintaining effective environmental management, especially in environmentally sensitive marine protected areas. It uses Shoalwater Bay Training Area (SWBTA) as a research example to examine environmental management strategies conducted by the ADF. SWBTA is one of the most significant Defence training areas in Australia, with a large number of single, joint and combined military exercises conducted in the area. With its maritime component contained in the Great Barrier Reef Marine Park (GBRMP), the Great Barrier Reef World Heritage Area (GBRWHA), and abutting Queensland’s State Marine Parks, it has high protection values. It is therefore vital for the ADF to adopt environmentally responsible management while they are conducting military activities. As to various tools employed to manage environmental performance, the ISO 14001 Environmental Management System (EMS) is widely used by the ADF. This paper examines military activities and marine environmental management within SWBTA, using the Talisman Saber (TS) exercise series as an example. These are extensive joint exercises conducted by the ADF and the United States defence forces. The paper outlines relevant legislative framework and environmental policies, analyses how the EMS operates in environmental management of military activities, and how military activities comply with these regulations. It discusses the implementation of the ADF EMS, including risk reduction measures, environmental awareness training, consultation and communication with stakeholders. A number of environmental management actions used in the TS exercises are presented to demonstrate the EMS application. Our investigations to this point indicate that the ADF is

  19. Dynamic state estimation assisted power system monitoring and protection

    NASA Astrophysics Data System (ADS)

    Cui, Yinan

    The advent of phasor measurement units (PMUs) has unlocked several novel methods to monitor, control, and protect bulk electric power systems. This thesis introduces the concept of "Dynamic State Estimation" (DSE), aided by PMUs, for wide-area monitoring and protection of power systems. Unlike traditional State Estimation where algebraic variables are estimated from system measurements, DSE refers to a process to estimate the dynamic states associated with synchronous generators. This thesis first establishes the viability of using particle filtering as a technique to perform DSE in power systems. The utility of DSE for protection and wide-area monitoring are then shown as potential novel applications. The work is presented as a collection of several journal and conference papers. In the first paper, we present a particle filtering approach to dynamically estimate the states of a synchronous generator in a multi-machine setting considering the excitation and prime mover control systems. The second paper proposes an improved out-of-step detection method for generators by means of angular difference. The generator's rotor angle is estimated with a particle filter-based dynamic state estimator and the angular separation is then calculated by combining the raw local phasor measurements with this estimate. The third paper introduces a particle filter-based dual estimation method for tracking the dynamic states of a synchronous generator. It considers the situation where the field voltage measurements are not readily available. The particle filter is modified to treat the field voltage as an unknown input which is sequentially estimated along with the other dynamic states. The fourth paper proposes a novel framework for event detection based on energy functions. The key idea is that any event in the system will leave a signature in WAMS data-sets. It is shown that signatures for four broad classes of disturbance events are buried in the components that constitute the

  20. ETV Program Report: Coatings for Wastewater Collection Systems - Protective Liner Systems, Inc., Epoxy Mastic, PLS-614

    EPA Science Inventory

    The Protective Liner Systems International, Inc. Epoxy Mastic PLS-614 coating used for wastewater collection system rehabilitation was evaluated by EPA’s Environmental Technology Verification Program under laboratory conditions at the Center for Innovative Grouting Material and T...

  1. Objective Metric Based Assessments for Efficient Evaluation of Auditory Situation Awareness Characteristics of Tactical Communications and Protective Systems (TCAPS) and Augmented Hearing Protective Devices (HPDs)

    DTIC Science & Technology

    2015-11-30

    Assessments for Efficient Evaluation of Auditory Situation Awareness Characteristics of Tactical Communications and Protective Systems (TCAPS) and Augmented...Hearing Protective Devices (HPDs) W81XWH-13-C-0193 John G. Casali, Ph.D, CPE & Kichol Lee, Ph.D Auditory Systems Lab, Industrial and Systems ...Suite 1 JBSA Lackland, TX 78236-9908 Approved for public release: distribution unlimited. The Virginia Tech Auditory Systems Laboratory (ASL

  2. Antibacterial activity and dentin bonding ability of combined use of Clearfil SE Protect and sodium hypochlorite.

    PubMed

    Muratovska, Ilijana; Kitagawa, Haruaki; Hirose, Nanako; Kitagawa, Ranna; Imazato, Satoshi

    2018-02-08

    The aim of this study was to evaluate the antibacterial activity and dentin bonding ability of a commercial self-etch adhesive Clearfil SE Protect (Kuraray Noritake Dental, Tokyo, Japan) in combination with sodium hypochlorite (NaOCl). Agar disc diffusion tests and measurement of minimum inhibitory/bactericidal concentrations (MIC/MBC) against Streptococcus mutans were performed to evaluate antibacterial effects. The mixture solution of 5.25% NaOCl and the primer of Clearfil SE Protect demonstrated less antibacterial activity than primer only. In microtensile bond strength tests using non-carious human molars, pretreatment with 5.25% NaOCl aqueous solution had no influence on the bond strength of Clearfil SE Protect. These results indicate that pretreatment with NaOCl does not influence the bonding ability of Clearfil SE Protect, while their combined use does not enhance cavity disinfecting effects.

  3. The mechanisms of protection of antioxidants on Nostoc sphaeroides against UV-B radiation

    NASA Astrophysics Data System (ADS)

    Wang, G. H.

    UV radiation is one of space harmful factor for earth organisms in space exploration In the present work we studied on the role of antioxidant system in Nostoc sphaeroides K u tz Cyanobacteria and the effects of exogenous antioxidant molecules on its photosynthetic rate under UV-B radiation It was found that UV-B radiation decreased the photosynthetic activity of cyanobacterium but promoted the activity of antioxidant system to protect photosystem II PSII and exogenous antioxidant sodium nitroprusside SNP N-acetylcysteine NAC had an obvious protection on PSII activity under UV-B radiation The activity of SOD Superoxide Dismutase EC 1 15 1 1 CAT Catalase EC 1 11 1 6 POD Peroxidase EC 1 11 1 7 and content of MDA and ASC were improved by 0 5mM and 1mM SNP but 0 1mM SNP decreased the activity of antioxide system Exogenous NAC addition decreased the activity of SOD POD CAT and the content MDA and ASC but exogenous NAC addition increased the content of GSH The results suggested that exogenous SNP and NAC may protect algae by different mechanisms in which SNP maybe play double roles as sources of reactive free radicals or ROS scavengers in formation of algae s protection of PSII under UV-B radiation while NAC does function as antioxidant reagent or precursor of glutathione which could protect PSII directly from UV-B radiation Keyword antioxidant system exogenous or endogenous antioxidant Nostoc sphaeroides photosynthesis UV-B radiation

  4. Workplace victimization risk and protective factors for suicidal behavior among active duty military personnel.

    PubMed

    Hourani, Laurel L; Williams, Jason; Lattimore, Pamela K; Morgan, Jessica K; Hopkinson, Susan G; Jenkins, Linda; Cartwright, Joel

    2018-04-22

    Workplace victimization is a potential risk factor for suicidal behaviors (SB) among military personnel that has been largely overlooked. This paper examines both the impact of workplace victimization on reported SB and several potential protective factors associated with such suicidal behaviors in a large sample of active duty soldiers. A case-control study was conducted with 71 soldiers who reported SB in the past 12 months, each matched on sociodemographic characteristics to two others without reported suicidal behaviors. A multiple regression model was estimated to assess the effects of risk and protective factors while controlling for other variables. SB was associated with several aspects of victimization, mental health and substance abuse conditions, pain, impulsivity, stressors, negative life events, work-family conflict, active coping behaviors and positive military-related factors. Controlling for other variables, those with SB were more likely to have sought mental health or substance abuse services, to be depressed, anxious, impulsive, and less resilient than non-SB personnel. Study limitations included the use of retrospective self-report data, absence of some known SB predictors, and a population restricted to active duty Army personnel. SB among active duty personnel is associated with victimization since joining the military and is protected by resiliency. These findings suggest that in addition to the usual mental health factors, these additional predictors should be accounted for in SB intervention and prevention planning for active duty personnel. Copyright © 2018 Elsevier B.V. All rights reserved.

  5. Active optical zoom system

    DOEpatents

    Wick, David V.

    2005-12-20

    An active optical zoom system changes the magnification (or effective focal length) of an optical imaging system by utilizing two or more active optics in a conventional optical system. The system can create relatively large changes in system magnification with very small changes in the focal lengths of individual active elements by leveraging the optical power of the conventional optical elements (e.g., passive lenses and mirrors) surrounding the active optics. The active optics serve primarily as variable focal-length lenses or mirrors, although adding other aberrations enables increased utility. The active optics can either be LC SLMs, used in a transmissive optical zoom system, or DMs, used in a reflective optical zoom system. By appropriately designing the optical system, the variable focal-length lenses or mirrors can provide the flexibility necessary to change the overall system focal length (i.e., effective focal length), and therefore magnification, that is normally accomplished with mechanical motion in conventional zoom lenses. The active optics can provide additional flexibility by allowing magnification to occur anywhere within the FOV of the system, not just on-axis as in a conventional system.

  6. Peptidergic Agonists of Activity-Dependent Neurotrophic Factor Protect Against Prenatal Alcohol-Induced Neural Tube Defects and Serotonin Neuron Loss

    PubMed Central

    Zhou, Feng C.; Fang, Yuan; Goodlett, Charles

    2009-01-01

    Introduction Prenatal alcohol exposure via maternal liquid diet consumption by C57BL/6 (B6) mice causes conspicuous midline neural tube deficit (dysraphia) and disruption of genesis and development of serotonin (5-HT) neurons in the raphe nuclei, together with brain growth retardation. The current study tested the hypothesis that concurrent treatment with either an activity-dependent neurotrophic factor (ADNF) agonist peptide [SALLRSIPA, (SAL)] or an activity-dependent neurotrophic protein (ADNP) agonist peptide [NAPVSIPQ, (NAP)] would protect against these alcohol-induced deficits in brain development. Methods Timed-pregnant B6 dams consumed alcohol from embryonic day 7 (E7, before the onset of neurulation) until E15. Fetuses were obtained on E15 and brain sections processed for 5-HT immunocytochemistry, for evaluation of morphologic development of the brainstem raphe and its 5-HT neurons. Additional groups were treated either with SAL or NAP daily from E7 to E15 to assess the potential protective effects of these peptides. Measures of incomplete occlusion of the ventral canal and the frequency and extent of the openings in the rhombencephalon were obtained to assess fetal dysraphia. Counts of 5-HT-immunostained neurons were also obtained in the rostral and caudal raphe. Results Prenatal alcohol exposure resulted in abnormal openings along the midline and delayed closure of ventral canal in the brainstem. This dysraphia was associated with reductions in the number of 5-HT neurons both in the rostral raphe nuclei (that gives rise to ascending 5-HT projections) and in the caudal raphe (that gives rise to the descending 5-HT projections). Concurrent treatment of the alcohol-consuming dams with SAL prevented dysraphia and protected against the alcohol-induced reductions in 5-HT neurons in both the rostral and caudal raphe. NAP was less effective in protecting against dysraphia and did not protect against 5-HT loss in the rostral raphe, but did protect against loss in

  7. Research on thermal protection mechanism of forward-facing cavity and opposing jet combinatorial thermal protection system

    NASA Astrophysics Data System (ADS)

    Lu, Hai-Bo; Liu, Wei-Qiang

    2014-04-01

    Validated by the correlated experiments, a nose-tip with forward-facing cavity/opposing jet/the combinatorial configuration of forward-facing cavity and opposing jet thermal protection system (TPS) are investigated numerically. The physical mechanism of these TPS is discussed, and the cooling efficiency of them is compared. The combinatorial system is more suitable to be the TPS for the high speed vehicles which need fly under various flow conditions with long-range and long time.

  8. Detailed test plans : Evaluation of Utah Transit Authority Connection Protection system

    DOT National Transportation Integrated Search

    2003-10-31

    The purpose of this evaluation is to assess the effectiveness of the Connection Protection (CP) system implemented by the Utah Transit Authority (UTA). The objective of the CP system is to improve the reliability of transfers from the higher frequenc...

  9. An ecological framework for informing permitting decisions on scientific activities in protected areas

    PubMed Central

    Saarman, Emily T.; Owens, Brian; Murray, Steven N.; Weisberg, Stephen B.; Field, John C.; Nielsen, Karina J.

    2018-01-01

    There are numerous reasons to conduct scientific research within protected areas, but research activities may also negatively impact organisms and habitats, and thus conflict with a protected area’s conservation goals. We developed a quantitative ecological decision-support framework that estimates these potential impacts so managers can weigh costs and benefits of proposed research projects and make informed permitting decisions. The framework generates quantitative estimates of the ecological impacts of the project and the cumulative impacts of the proposed project and all other projects in the protected area, and then compares the estimated cumulative impacts of all projects with policy-based acceptable impact thresholds. We use a series of simplified equations (models) to assess the impacts of proposed research to: a) the population of any targeted species, b) the major ecological assemblages that make up the community, and c) the physical habitat that supports protected area biota. These models consider both targeted and incidental impacts to the ecosystem and include consideration of the vulnerability of targeted species, assemblages, and habitats, based on their recovery time and ecological role. We parameterized the models for a wide variety of potential research activities that regularly occur in the study area using a combination of literature review and expert judgment with a precautionary approach to uncertainty. We also conducted sensitivity analyses to examine the relationships between model input parameters and estimated impacts to understand the dominant drivers of the ecological impact estimates. Although the decision-support framework was designed for and adopted by the California Department of Fish and Wildlife for permitting scientific studies in the state-wide network of marine protected areas (MPAs), the framework can readily be adapted for terrestrial and freshwater protected areas. PMID:29920527

  10. User-perceived reliability of unrepairable shared protection systems with functionally identical units

    NASA Astrophysics Data System (ADS)

    Ozaki, Hirokazu; Kara, Atsushi; Cheng, Zixue

    2012-05-01

    In this article, we investigate the reliability of M-for-N (M:N) shared protection systems. We focus on the reliability that is perceived by an end user of one of N units. We assume that any failed unit is instantly replaced by one of the M units (if available). We describe the effectiveness of such a protection system in a quantitative manner under the condition that the failed units are not repairable. Mathematical analysis gives the closed-form solution of the reliability and mean time to failure (MTTF). We also analyse several numerical examples of the reliability and MTTF. This result can be applied, for example, to the analysis and design of an integrated circuit consisting of redundant backup components. In such a device, repairing a failed component is unrealistic. The analysis provides useful information for the design for general shared protection systems in which the failed units are not repaired.

  11. Protection Enhances Community and Habitat Stability: Evidence from a Mediterranean Marine Protected Area

    PubMed Central

    Fraschetti, Simonetta; Guarnieri, Giuseppe; Bevilacqua, Stanislao; Terlizzi, Antonio; Boero, Ferdinando

    2013-01-01

    Rare evidences support that Marine Protected Areas (MPAs) enhance the stability of marine habitats and assemblages. Based on nine years of observation (2001–2009) inside and outside a well managed MPA, we assessed the potential of conservation and management actions to modify patterns of spatial and/or temporal variability of Posidonia oceanica meadows, the lower midlittoral and the shallow infralittoral rock assemblages. Significant differences in both temporal variations and spatial patterns were observed between protected and unprotected locations. A lower temporal variability in the protected vs. unprotected assemblages was found in the shallow infralittoral, demonstrating that, at least at local scale, protection can enhance community stability. Macrobenthos with long-lived and relatively slow-growing invertebrates and structurally complex algal forms were homogeneously distributed in space and went through little fluctuations in time. In contrast, a mosaic of disturbed patches featured unprotected locations, with small-scale shifts from macroalgal stands to barrens, and harsh temporal variations between the two states. Opposite patterns of spatial and temporal variability were found for the midlittoral assemblages. Despite an overall clear pattern of seagrass regression through time, protected meadows showed a significantly higher shoot density than unprotected ones, suggesting a higher resistance to local human activities. Our results support the assumption that the exclusion/management of human activities within MPAs enhance the stability of the structural components of protected marine systems, reverting or arresting threat-induced trajectories of change. PMID:24349135

  12. [Application of classified protection of information security in the information system of air pollution and health impact monitoring].

    PubMed

    Hao, Shuxin; Lü, Yiran; Liu, Jie; Liu, Yue; Xu, Dongqun

    2018-01-01

    To study the application of classified protection of information security in the information system of air pollution and health impact monitoring, so as to solve the possible safety risk of the information system. According to the relevant national standards and requirements for the information system security classified protection, and the professional characteristics of the information system, to design and implement the security architecture of information system, also to determine the protection level of information system. Basic security measures for the information system were developed in the technical safety and management safety aspects according to the protection levels, which effectively prevented the security risk of the information system. The information system established relatively complete information security protection measures, to enhanced the security of professional information and system service, and to ensure the safety of air pollution and health impact monitoring project carried out smoothly.

  13. NASA Crew Exploration Vehicle, Thermal Protection System, Lessons Learned

    NASA Technical Reports Server (NTRS)

    Venkatapathy, Ethiraj; Reuther, James

    2008-01-01

    The Orion (CEV) thermal protection system (TPS) advanced development project (ADP) was initiated in late 2006 to reduce developmental risk by significant investment in multiple heat shield architectural solutions that can meet the needs both the Low Earth orbit (LEO) and Lunar return missions. At the same time, the CEV TPS ADP was also charged with developing a preliminary design for the heat shield to meet the PDR requirement and at the time of the PDR, transfer the design to Lockheed- Martin, the prime contractor. We reported on the developmental activities of the first 18 months at the IPPW5 in Bordeaux, France, last summer. In June 08, at the time of the IPPW6, the CEV TPS ADP would have nearly completed the preparation for the Orion PDR and would be close to the original three-year mark. We plan to report on the progress at the Atlanta workshop. In the past year, Orion TPS ADP investment in TPS Technology, especially in PICA ablative Heat-shield design, development, testing and engineering (DDTE) has paid off in enabling MSL mission to switch from SLA 561 V heat shield to PICA heat shield. CEV TPS ADP considered SLA 561 V as a candidate for LEO missions and our testing identified failure modes in SLA and as a result, we dropped SLA for further evaluation. This close synergy between two projects is a highly visible example of how investment in technology areas can and does benefit multiple missions. In addition, CEV TPS ADP has been able to revive the Apollo ablative system namely AVCOAT honeycomb architecture as an alternate to the baseline PICA architecture and we plan to report the progress we have made in AVCOAT. CEV TPS ADP has invested considerable resources in developing analytical models for PICA and AVCOAT, material property measurements that is essential to the design of the heat-shield, in arcjet testing, in understanding the differences between different arc jet facilities, namely NASA Ames, NASA JSC and Air Force's AEDC, and in Non

  14. Prototype sampling system for measuring workplace protection factors for gases and vapors.

    PubMed

    Groves, William A; Reynolds, Stephen J

    2003-05-01

    A prototype sampling system for measuring respirator workplace protection factors (WPFs) was developed. Methods for measuring the concentration of contaminants inside respirators have previously been described; however, these studies have typically involved continuous sampling of aerosols. Our work focuses on developing an intermittent sampling system designed to measure the concentration of gases and vapors during inspiration. This approach addresses two potential problems associated with continuous sampling: biased results due to lower contaminant concentrations and high humidity in exhaled air. The system consists of a pressure transducer circuit designed to activate a pair of personal sampling pumps during inspiration based on differential pressure inside the respirator. One pump draws air from inside the respirator while the second samples the ambient air. Solid granular adsorbent tubes are used to trap the contaminants, making the approach applicable to a large number of gases and vapors. Laboratory testing was performed using a respirator mounted on a headform connected to a breathing machine producing a sinusoidal flow pattern with an average flow rate of 20 L/min and a period of 3 seconds. The sampling system was adjusted to activate the pumps when the pressure inside the respirator was less than -0.1 inch H(2)O. Quantitative fit-tests using human subjects were conducted to evaluate the effect of the sampling system on respirator performance. A total of 299 fit-tests were completed for two different types of respirators (half- and full-facepiece) from two different manufacturers (MSA and North). Statistical tests showed no significant differences between mean fit factors for respirators equipped with the sampling system versus unmodified respirators. Field testing of the prototype sampling system was performed in livestock production facilities and estimates of WPFs for ammonia were obtained. Results demonstrate the feasibility of this approach and will be

  15. A privacy protection for an mHealth messaging system

    NASA Astrophysics Data System (ADS)

    Aaleswara, Lakshmipathi; Akopian, David; Chronopoulos, Anthony T.

    2015-03-01

    In this paper, we propose a new software system that employs features that help the organization to comply with USA HIPAA regulations. The system uses SMS as the primary way of communication to transfer information. Lack of knowledge about some diseases is still a major reason for some harmful diseases spreading. The developed system includes different features that may help to communicate amongst low income people who don't even have access to the internet. Since the software system deals with Personal Health Information (PHI) it is equipped with an access control authentication system mechanism to protect privacy. The system is analyzed for performance to identify how much overhead the privacy rules impose.

  16. Moricandia arvensis extracts protect against DNA damage, mutagenesis in bacteria system and scavenge the superoxide anion.

    PubMed

    Skandrani, Ines; Bouhlel, Ines; Limem, Ilef; Boubaker, Jihed; Bhouri, Wissem; Neffati, Aicha; Ben Sghaier, Mohamed; Kilani, Soumaya; Ghedira, Kamel; Ghedira-Chekir, Leila

    2009-02-01

    The mutagenic potential of total aqueous, total oligomers flavonoids (TOF), ethyl acetate (EA), chloroform (Chl), petroleum ether (PE) and methanol (MeOH) extracts from aerial parts of Moricandia arvensis was assessed using Ames Salmonella tester strains TA100 and TA1535 with and without metabolic activation (S9), and using plasmid pBluescript DNA assay. None of the different extracts produced a mutagenic effect, except aqueous extract when incubated with Salmonella typhimurium TA100 after metabolic activation. Likewise, the antimutagenicity of the same extracts was tested using the "Ames test". Our results showed that M. arvensis extracts possess antimutagenic effects against sodium azide (SA) in the two tested Salmonella assay systems, except metabolized aqueous and PE extracts when tested with S. typhimurium TA100 assay system. Different extracts were also found to be effective in protecting plasmid DNA against the strand breakage induced by hydroxyl radicals, except PE and aqueous extracts. Antioxidant capacity of the tested extracts was evaluated using the enzymatic (xanthine/xanthine oxidase assay) (X/XOD) and the non enzymatic (NBT/Riboflavine assay) systems. TOF extract was the more effective one in inhibiting both xanthine oxidase activity and NBT reduction.

  17. FAK/Src family of kinases: protective or aggravating factor for ischemia reperfusion injury in nervous system?

    PubMed

    Bikis, Christos; Moris, Demetrios; Vasileiou, Ioanna; Patsouris, Eustratios; Theocharis, Stamatios

    2015-04-01

    The focal adhesion kinase (FAK) and the Src families of kinases are subfamilies of the non-receptor protein tyrosine kinases. FAK activity is regulated by gene amplification, alternative splicing and phosporylation/dephosphorylation. FAK/Src complex has been found to participate through various pathways in neuronal models of ischemia-reperfusion injury (IRI) with conflicting results. The aim of the present review is to summarize the currently available data on this subject. The MEDLINE/PubMed database was searched for publications with the medical subject heading IRI and FAK and/or Src, nervous system. We restricted our search till 2014. We identified 93 articles that were available in English as abstracts or/and full-text articles that were deemed appropriate for our review. FAK has been found to have a beneficial preconditioning effect on IRI through activation via the protein kinase C (PKC) pathway by anesthetic agents. Of great importance are the interactions between FAK/Src and VEGF that has been already detected as a protective mean for IRI. The effect of VEGF administration might depend on dose as well as on time of administration. A Ca(2+)/calmodulin-dependent protein kinase II or PKC inhibitors seem to have protective effects on IRI by inhibiting ion channels activation.

  18. Prototype design of a collision protection system for cab car engineers.

    DOT National Transportation Integrated Search

    2013-03-01

    The objective of this project was to develop and analyze a passive system to protect a cab car engineer from secondary impact injuries that might be experienced due to impact with the cab console. The primary requirement for the system was the abilit...

  19. Thermal protection system ablation sensor

    NASA Technical Reports Server (NTRS)

    Gorbunov, Sergey (Inventor); Martinez, Edward R. (Inventor); Scott, James B. (Inventor); Oishi, Tomomi (Inventor); Fu, Johnny (Inventor); Mach, Joseph G. (Inventor); Santos, Jose B. (Inventor)

    2011-01-01

    An isotherm sensor tracks space vehicle temperatures by a thermal protection system (TPS) material during vehicle re-entry as a function of time, and surface recession through calibration, calculation, analysis and exposed surface modeling. Sensor design includes: two resistive conductors, wound around a tube, with a first end of each conductor connected to a constant current source, and second ends electrically insulated from each other by a selected material that becomes an electrically conductive char at higher temperatures to thereby complete an electrical circuit. The sensor conductors become shorter as ablation proceeds and reduced resistance in the completed electrical circuit (proportional to conductor length) is continually monitored, using measured end-to-end voltage change or current in the circuit. Thermocouple and/or piezoelectric measurements provide consistency checks on local temperatures.

  20. Protective activity of Hertia cheirifolia extracts against DNA damage, lipid peroxidation and protein oxidation.

    PubMed

    Kada, Seoussen; Bouriche, Hamama; Senator, Abderrahmane; Demirtaş, Ibrahim; Özen, Tevfik; Çeken Toptanci, Bircan; Kızıl, Göksel; Kızıl, Murat

    2017-12-01

    Hertia cheirifolia L. (Asteraceae), a perennial shrub widely distributed in Northern Africa, is traditionally used to treat inflammatory disorders. The protective effect of methanol (Met E) and aqueous (Aq E) extracts of Hertia cheirifolia against DNA, lipid and protein oxidation was investigated. Different concentrations (50-1000 μg/mL) of Hertia cheirifolia aerial part extracts were examined against DNA, lipid and protein oxidation induced by H 2 O 2  + UV, FeSO 4 , and Fe 3+ /H 2 O 2 -ascorbic acid, respectively. The DPPH • , metal ion chelating, reducing power and β-carotene bleaching tests were conducted. Both extracts were rich in polyphenols, flavonoids and tannins, and were able to scavenge DPPH • with IC 50 values of 138 and 197 μg/mL, respectively. At 300 μg/mL, Aq E exerted stronger chelating effect (99%) than Met E (69%). However, Met E reducing power (IC 50  =   61 μg/mL) was more than that of Aq E (IC 50  =   193 μg/mL). Both extracts protected from β-carotene bleaching by 74% and 94%, respectively, and inhibited linoleic acid peroxidation. The inhibitory activity of Aq E extract (64%) was twice more than that of Met E (32%). Interestingly, both extracts protected DNA against the cleavage by about 96-98%. At 1 mg/mL, Met E and Aq E restored protein band intensity by 94-99%. Hertia cheirifolia exhibits potent antioxidant activity and protects biomolecules against oxidative damage; hence, it may serve as potential source of natural antioxidant for pharmaceutical applications and food preservation. This is the first report on the protective activity of this plant against biomolecule oxidation.

  1. A Combined Water-Bromotrifluoromethane Crash-Fire Protection System for a T-56 Turbopropeller Engine

    NASA Technical Reports Server (NTRS)

    Campbell, John A.; Busch, Arthur M.

    1959-01-01

    A crash-fire protection system is described which will suppress the ignition of crash-spilled fuel that may be ingested by a T-56 turbo-propeller engine. This system includes means for rapidly extinguishing the combustor flame, means for cooling and inerting with water the hot engine parts likely to ignite engine ingested fuel, and means for blanketing with bromotrifluoromethane massive metal parts that may reheat after the engine stops rotating. Combustion-chamber flames were rapidly extinguished at the engine fuel nozzles by a fuel shutoff and drain valve. Hot engine parts were inerted and cooled by 42 pounds of water discharged at seven engine stations. Massive metal parts that could reheat were inerted with 10 pounds of bromotrifluoromethane discharged at two engine stations. Performance trials of the crash-fire protection system were conducted by bringing the engine up to takeoff temperature, actuating the crash-fire protection system, and then spraying fuel into the engine to simulate crash-ingested fuel. No fires occurred during these trials, although fuel was sprayed into the engine from 0.3 second to 15 minutes after actuating the crash-fire protection system.

  2. Numerical investigation on properties of attack angle for an opposing jet thermal protection system

    NASA Astrophysics Data System (ADS)

    Lu, Hai-Bo; Liu, Wei-Qiang

    2012-08-01

    The three-dimensional Navier—Stokes equation and the k-in viscous model are used to simulate the attack angle characteristics of a hemisphere nose-tip with an opposing jet thermal protection system in supersonic flow conditions. The numerical method is validated by the relevant experiment. The flow field parameters, aerodynamic forces, and surface heat flux distributions for attack angles of 0°, 2°, 5°, 7°, and 10° are obtained. The detailed numerical results show that the cruise attack angle has a great influence on the flow field parameters, aerodynamic force, and surface heat flux distribution of the supersonic vehicle nose-tip with an opposing jet thermal protection system. When the attack angle reaches 10°, the heat flux on the windward generatrix is close to the maximal heat flux on the wall surface of the nose-tip without thermal protection system, thus the thermal protection has failed.

  3. Radiation protection for manned space activities

    NASA Technical Reports Server (NTRS)

    Jordan, T. M.

    1983-01-01

    The Earth's natural radiation environment poses a hazard to manned space activities directly through biological effects and indirectly through effects on materials and electronics. The following standard practices are indicated that address: (1) environment models for all radiation species including uncertainties and temporal variations; (2) upper bound and nominal quality factors for biological radiation effects that include dose, dose rate, critical organ, and linear energy transfer variations; (3) particle transport and shielding methodology including system and man modeling and uncertainty analysis; (4) mission planning that includes active dosimetry, minimizes exposure during extravehicular activities, subjects every mission to a radiation review, and specifies operational procedures for forecasting, recognizing, and dealing with large solar flaes.

  4. Inactivated Influenza Vaccine That Provides Rapid, Innate-Immune-System-Mediated Protection and Subsequent Long-Term Adaptive Immunity.

    PubMed

    Chua, Brendon Y; Wong, Chinn Yi; Mifsud, Edin J; Edenborough, Kathryn M; Sekiya, Toshiki; Tan, Amabel C L; Mercuri, Francesca; Rockman, Steve; Chen, Weisan; Turner, Stephen J; Doherty, Peter C; Kelso, Anne; Brown, Lorena E; Jackson, David C

    2015-10-27

    The continual threat to global health posed by influenza has led to increased efforts to improve the effectiveness of influenza vaccines for use in epidemics and pandemics. We show in this study that formulation of a low dose of inactivated detergent-split influenza vaccine with a Toll-like receptor 2 (TLR2) agonist-based lipopeptide adjuvant (R4Pam2Cys) provides (i) immediate, antigen-independent immunity mediated by the innate immune system and (ii) significant enhancement of antigen-dependent immunity which exhibits an increased breadth of effector function. Intranasal administration of mice with vaccine formulated with R4Pam2Cys but not vaccine alone provides protection against both homologous and serologically distinct (heterologous) viral strains within a day of administration. Vaccination in the presence of R4Pam2Cys subsequently also induces high levels of systemic IgM, IgG1, and IgG2b antibodies and pulmonary IgA antibodies that inhibit hemagglutination (HA) and neuraminidase (NA) activities of homologous but not heterologous virus. Improved primary virus nucleoprotein (NP)-specific CD8(+) T cell responses are also induced by the use of R4Pam2Cys and are associated with robust recall responses to provide heterologous protection. These protective effects are demonstrated in wild-type and antibody-deficient animals but not in those depleted of CD8(+) T cells. Using a contact-dependent virus transmission model, we also found that heterologous virus transmission from vaccinated mice to naive mice is significantly reduced. These results demonstrate the potential of adding a TLR2 agonist to an existing seasonal influenza vaccine to improve its utility by inducing immediate short-term nonspecific antiviral protection and also antigen-specific responses to provide homologous and heterologous immunity. The innate and adaptive immune systems differ in mechanisms, specificities, and times at which they take effect. The innate immune system responds within hours of

  5. Limited Investigation of Active Feel Control Stick System (Active Stick)

    DTIC Science & Technology

    2009-06-01

    contained no limit protection and was the baseline system. The second system was “F-16 like” and contained angle -of-attack and load factor limiting...system. The second system was “F-16 like” and contained angle of attack (AOA) and load factor limiting features built into the flight control system...Force PTI at VLO .......................... 13 Figure 9: Pitch Angle Response to 1.5 g Commanded Force PTI at VLO ........................ 14 Figure 10

  6. Heath Monitoring of Thermal Protection Systems - Preliminary Measurements and Design Specifications

    NASA Technical Reports Server (NTRS)

    Scott, D. A.; Price, D. C.

    2007-01-01

    The work reported here is the first stage of a project that aims to develop a health monitoring system for Thermal Protection Systems (TPS) that enables a vehicle to safely re-enter the Earth's atmosphere. The TPS health monitoring system is to be integrated into an existing acoustic emissions-based Concept Demonstrator, developed by CSIRO, which has been previously demonstrated for evaluating impact damage of aerospace systems.

  7. Large Crawler Crane for new lightning protection system

    NASA Image and Video Library

    2007-10-25

    A large crawler crane traveling long one of the crawlerway tracks makes the turn toward Launch Pad 39B. The crane with its 70-foot boom will be used to construct a new lightning protection system for the Constellation Program and Ares/Orion launches. Pad B will be the site of the first Ares vehicle launch, including Ares I-X which is scheduled for April 2009.

  8. Large Crawler Crane for new lightning protection system

    NASA Image and Video Library

    2007-10-25

    A large crawler crane travels along one of the crawlerway tracks on its way to Launch Pad 39B. The crane with its 70-foot boom will be used to construct a new lightning protection system for the Constellation Program and Ares/Orion launches. Pad B will be the site of the first Ares vehicle launch, including Ares I-X which is scheduled for April 2009.

  9. Large Crawler Crane for new lightning protection system

    NASA Image and Video Library

    2007-10-25

    A large crawler crane moves past the Vehicle Assembly Building on its way to Launch Pad 39B. The crane with its 70-foot boom will be used to construct a new lightning protection system for the Constellation Program and Ares/Orion launches. Pad B will be the site of the first Ares vehicle launch, including Ares I-X which is scheduled for April 2009.

  10. Optimization of intracerebral tumour protection by active-specific immunization against murine melanoma B16/G3.12.

    PubMed

    Staib, L; Harel, W; Mitchell, M S

    2001-08-01

    Development of brain metastases despite extracerebral response to systemic immunotherapy is a common problem in melanoma patients. We have previously described a murine melanoma vaccine of interferon-gamma (IFNgamma)-treated, irradiated syngeneic B16/G3.12 and allogeneic (Cloudman) melanoma cells, plus the adjuvant DETOX, that is protective against subcutaneous (93%) or intracerebral (69%) syngeneic challenge. This study aimed to optimize this vaccine. Groups of nine or 10 mice were immunized five times in 5 weeks with: (i) complete vaccine +/- IFNgamma (VAC+, VAC-); (ii) syngeneic 2 x 106 G3.12 cells plus DETOX (Syn+D), (iii) 2 x 106 allogeneic Cloudman cells plus DETOX (Allo+D); (iv) VAC+ without DETOX (no DETOX); (v) DETOX alone (DETOX); or (vi) phosphate buffered saline (PBS). Mice were challenged subcutaneously with 104 viable G3.12 (or Cloudman cells) and after 35 days intracerebrally with 104 G3.12 cells. Expression of H-2 antigens (measured using fluorescence-activated cell sorting), splenocyte cytotoxicity (measured using 51Cr release) and median overall survival (OAS) were analysed using the log-rank test. VAC+, VAC- and G3.12 mice were equally protected from subcutaneous (s.c.) and intracerebral (i.c.) melanoma challenge (OAS 65 days for s.c., 30 days for i.c.). Protection was less (P < 0.05) in DETOX mice (48 days for s.c.), PBS mice (47 days for s.c., 21 days for i.c.) or no DETOX mice (51 days for s.c.). Allo+D mice showed s.c. (59 days) but not i.c. protection (20 days). IFNgamma incubation did not increase the effect in either the challenge cells or the vaccine cells (P > 0.05). Specific cytotoxicity was seen with G3.12 targets in VAC+ (27%) but not PBS (2%; P < 0.05) mice with equal NK (YAC-1) lysis (10% versus 7%; P< 0.05). Optimal protection against s.c./i.c. experimental murine melanoma was yielded by irradiated syngeneic cells plus DETOX. DETOX alone was not active. Upregulation of H-2 antigens with IFNgamma under these conditions does not

  11. Peroxisome proliferator-activated receptor delta (PPARdelta) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis.

    PubMed

    Pesant, Matthieu; Sueur, Stéphanie; Dutartre, Patrick; Tallandier, Mireille; Grimaldi, Paul A; Rochette, Luc; Connat, Jean-Louis

    2006-02-01

    Activation of peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma plays beneficial roles in cardiovascular disorders such as atherosclerosis and heart reperfusion. Although PPARalpha and gamma have been documented to reduce oxidative stress in the vasculature and the heart, the role of PPARdelta remains poorly studied. We focused on PPARdelta function in the regulation of oxidative stress-induced apoptosis in the rat cardiomyoblast cell line H9c2. Using semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), we showed that PPARdelta is the predominantly expressed isotype whereas PPARalpha was weakly detected. By performing cell viability assays, we also showed that the selective PPARdelta agonist GW501516 protected cells from H(2)O(2)-induced cell death. The protective effect of GW501516 was due to an inhibition of H(2)O(2)-triggered apoptosis as shown by annexin-V labeling, DNA fragmentation analysis, and caspase-3 activity measurement. We demonstrated by transient transfection of a dominant negative mutant of PPARdelta that the protection induced by GW501516 was totally dependent on PPARdelta. Semi-quantitative RT-PCR and Western blotting analysis demonstrated that GW501516 treatment upregulated catalase. Moreover, forced overexpression of catalase inhibited H(2)O(2)-triggered apoptosis, as evidenced by annexin-V labeling. Taken together, our results account for an important role of PPARdelta in inhibiting the onset of oxidative stress-induced apoptosis in H9c2 cells. PPARdelta appears to be a new therapeutic target for the regulation of heart reperfusion-associated oxidative stress and stimulation of enzymatic antioxidative defences.

  12. The application of machine vision in fire protection system

    NASA Astrophysics Data System (ADS)

    Rong, Jiang

    2018-04-01

    Based on the previous research, this paper introduces the theory of wavelet, collects the situation through the video system, and calculates the key information needed in the fire protection system. That is, through the algorithm to collect the information, according to the flame color characteristics and smoke characteristics were extracted, and as the characteristic information corresponding processing. Alarm system set the corresponding alarm threshold, when more than this alarm threshold, the system will alarm. This combination of flame color characteristics and smoke characteristics of the fire method not only improve the accuracy of judgment, but also improve the efficiency of judgments. Experiments show that the scheme is feasible.

  13. Use of protected activity centers by Mexican Spotted Owls in the Sacramento Mountains, New Mexico

    Treesearch

    Joseph L. Ganey; James P. Ward; Jeffrey S. Jenness; William M. Block; Shaula Hedwall; Ryan S. Jonnes; Darrell L. Apprill; Todd A. Rawlinson; Sean C. Kyle; Steven L. Spangle

    2014-01-01

    A Recovery Plan developed for the threatened Mexican Spotted Owl (Strix occidentalis lucida) recommended designating Protected Activity Centers (PACs) with a minimum size of 243 ha to conserve core use areas of territorial owls. The plan assumed that areas of this size would protect " the nest site, several roost sites, and the most proximal and highly-used...

  14. Lightweight Thermal Protection System for Atmospheric Entry

    NASA Technical Reports Server (NTRS)

    Stewart, David; Leiser, Daniel

    2007-01-01

    TUFROC (Toughened Uni-piece Fibrous Reinforced Oxidation-resistant Composite) has been developed as a new thermal protection system (TPS) material for wing leading edge and nose cap applications. The composite withstands temperatures up to 1,970 K, and consists of a toughened, high-temperature surface cap and a low-thermal-conductivity base, and is applicable to both sharp and blunt leading edge vehicles. This extends the possible application of fibrous insulation to the wing leading edge and/or nose cap on a hypersonic vehicle. The lightweight system comprises a treated carbonaceous cap composed of ROCCI (Refractory Oxidation-resistant Ceramic Carbon Insulation), which provides dimensional stability to the outer mold line, while the fibrous base material provides maximum thermal insulation for the vehicle structure.

  15. Container lid gasket protective strip for double door transfer system

    DOEpatents

    Allen, Jr., Burgess M

    2013-02-19

    An apparatus and a process for forming a protective barrier seal along a "ring of concern" of a transfer container used with double door systems is provided. A protective substrate is supplied between a "ring of concern" and a safety cover in which an adhesive layer of the substrate engages the "ring of concern". A compressive foam strip along an opposite side of the substrate engages a safety cover such that a compressive force is maintained between the "ring of concern" and the adhesive layer of the substrate.

  16. Personal Radiation Protection System

    NASA Technical Reports Server (NTRS)

    McDonald, Mark; Vinci, Victoria

    2004-01-01

    A report describes the personal radiation protection system (PRPS), which has been invented for use on the International Space Station and other spacecraft. The PRPS comprises walls that can be erected inside spacecraft, where and when needed, to reduce the amount of radiation to which personnel are exposed. The basic structural modules of the PRPS are pairs of 1-in. (2.54-cm)-thick plates of high-density polyethylene equipped with fasteners. The plates of each module are assembled with a lap joint. The modules are denoted bricks because they are designed to be stacked with overlaps, in a manner reminiscent of bricks, to build 2-in. (5.08-cm)-thick walls of various lengths and widths. The bricks are of two varieties: one for flat wall areas and one for corners. The corner bricks are specialized adaptations of the flat-area bricks that make it possible to join walls perpendicular to each other. Bricks are attached to spacecraft structures and to each other by use of straps that can be tightened to increase the strengths and stiffnesses of joints.

  17. Killed but metabolically active Bacillus anthracis vaccines induce broad and protective immunity against anthrax.

    PubMed

    Skoble, Justin; Beaber, John W; Gao, Yi; Lovchik, Julie A; Sower, Laurie E; Liu, Weiqun; Luckett, William; Peterson, Johnny W; Calendar, Richard; Portnoy, Daniel A; Lyons, C Rick; Dubensky, Thomas W

    2009-04-01

    Bacillus anthracis is the causative agent of anthrax. We have developed a novel whole-bacterial-cell anthrax vaccine utilizing B. anthracis that is killed but metabolically active (KBMA). Vaccine strains that are asporogenic and nucleotide excision repair deficient were engineered by deleting the spoIIE and uvrAB genes, rendering B. anthracis extremely sensitive to photochemical inactivation with S-59 psoralen and UV light. We also introduced point mutations into the lef and cya genes, which allowed inactive but immunogenic toxins to be produced. Photochemically inactivated vaccine strains maintained a high degree of metabolic activity and secreted protective antigen (PA), lethal factor, and edema factor. KBMA B. anthracis vaccines were avirulent in mice and induced less injection site inflammation than recombinant PA adsorbed to aluminum hydroxide gel. KBMA B. anthracis-vaccinated animals produced antibodies against numerous anthrax antigens, including high levels of anti-PA and toxin-neutralizing antibodies. Vaccination with KBMA B. anthracis fully protected mice against challenge with lethal doses of toxinogenic unencapsulated Sterne 7702 spores and rabbits against challenge with lethal pneumonic doses of fully virulent Ames strain spores. Guinea pigs vaccinated with KBMA B. anthracis were partially protected against lethal Ames spore challenge, which was comparable to vaccination with the licensed vaccine anthrax vaccine adsorbed. These data demonstrate that KBMA anthrax vaccines are well tolerated and elicit potent protective immune responses. The use of KBMA vaccines may be broadly applicable to bacterial pathogens, especially those for which the correlates of protective immunity are unknown.

  18. Opsonic and protective activity of immunoglobulin, modified immunoglobulin, and serum against neonatal Escherichia coli K1 infection.

    PubMed

    Bortolussi, R; Fischer, G W

    1986-02-01

    Because modified immune serum globulin (M-ISG) has been proposed for therapy in neonatal bacterial sepsis, we evaluated it in a suckling rat model of Escherichia coli K1 sepsis. We compared a M-ISG preparation (lot 2581), which was protective against group B streptococcal (GBS) sepsis, with other M-ISG, standard ISG preparations and with adult and cord serum. All immune serum preparations and sera demonstrated opsonic activity against E. coli K1 and were superior to saline in protecting against death due to E. coli K1 sepsis. Survival rates were higher for one M-ISG preparation (lot 2581) than for randomly selected standard immune serum globulin and cord sera but were similar to adult sera in these protection studies. Therapeutic and opsonic activity of standard immune serum globulin and M-ISG prepared from the same donors were similar, suggesting that the different processes used for their manufacture did not affect these activities. Because the M-ISG preparation studied showed protective activity to both GBS and E. coli K1, we studied it further by adsorbing the preparation with GBS and E. coli K1. Opsonic activity to E. coli K1 was removed by E. coli adsorption but not by adsorption with GBS, indicating that this activity was not due to a single cross-reacting antibody. Empirical therapy with M-ISG prescreened for opsonic activity to both E. coli K1 and GBS may be of clinical value. Trials appear warranted to study the pharmacology and efficacy of M-ISG in septic newborns.

  19. 21 CFR 1240.86 - Protection of pier water system.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Protection of pier water system. 1240.86 Section 1240.86 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND DRUG ADMINISTRATION CONTROL OF COMMUNICABLE...

  20. A patient privacy protection scheme for medical information system.

    PubMed

    Lu, Chenglang; Wu, Zongda; Liu, Mingyong; Chen, Wei; Guo, Junfang

    2013-12-01

    In medical information systems, there are a lot of confidential information about patient privacy. It is therefore an important problem how to prevent patient's personal privacy information from being disclosed. Although traditional security protection strategies (such as identity authentication and authorization access control) can well ensure data integrity, they cannot prevent system's internal staff (such as administrators) from accessing and disclosing patient privacy information. In this paper, we present an effective scheme to protect patients' personal privacy for a medical information system. In the scheme, privacy data before being stored in the database of the server of a medical information system would be encrypted using traditional encryption algorithms, so that the data even if being disclosed are also difficult to be decrypted and understood. However, to execute various kinds of query operations over the encrypted data efficiently, we would also augment the encrypted data with additional index, so as to process as much of the query as possible at the server side, without the need to decrypt the data. Thus, in this paper, we mainly explore how the index of privacy data is constructed, and how a query operation over privacy data is translated into a new query over the corresponding index so that it can be executed at the server side immediately. Finally, both theoretical analysis and experimental evaluation validate the practicality and effectiveness of our proposed scheme.