Calculation of tip clearance effects in a transonic compressor rotor

NASA Technical Reports Server (NTRS)

Chima, R. V.

1996-01-01

The flow through the tip clearance region of a transonic compressor rotor (NASA rotor 37) was computed and compared to aerodynamic probe and laser anemometer data. Tip clearance effects were modeled both by gridding the clearance gap and by using a simple periodicity model across the ungridded gap. The simple model was run with both the full gap height, and with half the gap height to simulate a vena-contracta effect. Comparisons between computed and measured performance maps and downstream profiles were used to validate the models and to assess the effects of gap height on the simple clearance model. Recommendations were made concerning the use of the simple clearance model. Detailed comparisons were made between the gridded clearance gap solution and the laser anemometer data near the tip at two operating points. The computer results agreed fairly well with the data but overpredicted the extent of the casing separation and underpredicted the wake decay rate. The computations were then used to describe the interaction of the tip vortex, the passage shock, and the casing boundary layer.

Fuel conservation through active control of rotor clearances

NASA Technical Reports Server (NTRS)

Beitler, R. S.; Saunders, A. A.; Wanger, R. P.

1980-01-01

Under the NASA-sponsored Energy Efficient Engine (EEE) Project, technology is being developed which will significantly reduce the fuel consumption of turbofan engines for subsonic transport aircraft. One technology concept being pursued is active control of rotor tip clearances. Attention is given to rotor tip clearance considerations and an overview of preliminary study results as well as the General Electric EEE clearance control approach is presented. Finally, potential fuel savings with active control of rotor clearances for a typical EEE mission are predicted.

Turbo machine tip clearance and vibration measurements using a fibre optic laser Doppler position sensor

NASA Astrophysics Data System (ADS)

Pfister, T.; Büttner, L.; Czarske, J.; Krain, H.; Schodl, R.

2006-07-01

This paper presents a novel fibre optic laser Doppler position sensor for single blade tip clearance and vibration measurements at turbo machines, which offers high temporal resolution and high position resolution simultaneously. The sensor principle is based on the generation of a measurement volume consisting of two superposed fan-like interference fringe systems with contrary fringe spacing gradients using wavelength division multiplexing. A flexible and robust measurement system with an all-passive fibre coupled measurement head has been realized employing diffractive and refractive optics. Measurements of tip clearance and rotor vibrations at a transonic centrifugal compressor performed during operation at up to 50 000 rpm (833 Hz) corresponding to 21.7 kHz blade frequency and 586 m s-1 blade tip velocity are presented. The results are in excellent agreement with those of capacitive probes. The mean uncertainty of the position measurement was around 20 µm and, thus, considerably better than for conventional tip clearance probes. Consequently, this sensor is capable of fulfilling the requirements for future active clearance control systems and has great potential for in situ and online tip clearance and vibration measurements at metallic and non-metallic turbine blades with high precision.

Experimental Study of Unshrouded Impeller Pump Stage Sensitivity to Tip Clearance

NASA Technical Reports Server (NTRS)

Williams, Robert W.; Zoladz, Thomas; Storey, Anne K.; Skelley, Stephen E.

2002-01-01

This viewgraph presentation provides information on an experiment. Its objective is to experimentally determine unshrouded impeller performance sensitivity to tip clearance. The experiment included: Determining impeller efficiency at scaled operating conditions in water at MSFC's Pump Test Equipment (PTE) Facility; Testing unshrouded impeller at three different tip clearances; Testing each tip clearance configuration at on- and off-design conditions, and collecting unsteady- and steady-state data in each configuration; Determining impeller efficiency directly using drive line torquemeter and pump inlet and exit total pressure measurements.

Controls Considerations for Turbine Active Clearance Control

NASA Technical Reports Server (NTRS)

Melcher, Kevin J.

2004-01-01

This presentation discusses active control of turbine tip clearance from a control systems perspective. It is a subset of charts that were presented at the 2003 meeting of the International Society of Air Breathing Engines which was held August 31 through September 5 in Cleveland, Ohio. The associated reference paper is cited at the end of the presentation. The presentation describes active tip clearance control research being conducted by NASA to improve turbine engine systems. The target application for this effort is commercial aircraft engines. However, it is believed that the technologies developed as part of this research will benefit a broad spectrum of current and future turbomachinery. The first part of the presentation discusses the concept of tip clearance, problems associated with it, and the benefits of controlling it. It lays out a framework for implementing tip clearance controls that enables the implementation to progress from purely analytical to hardware-in-the-loop to fully experimental. And it briefly discusses how the technologies developed will be married to the previously described ACC Test Rig for hardware-in-the-loop demonstrations. The final portion of the presentation, describes one of the key technologies in some detail by presenting equations and results for a functional dynamic model of the tip clearance phenomena. As shown, the model exhibits many of the clearance dynamics found in commercial gas turbine engines. However, initial attempts to validate the model identified limitations that are being addressed to make the model more realistic.

Testing of a Microwave Blade Tip Clearance Sensor at the NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Woike, Mark R.; Roeder, James W.; Hughes, Christopher E.; Bencic, Timothy J.

2009-01-01

The development of new active tip clearance control and structural health monitoring schemes in turbine engines and other types of rotating machinery requires sensors that are highly accurate and can operate in a high-temperature environment. The use of a microwave sensor to acquire blade tip clearance and tip timing measurements is being explored at the NASA Glenn Research Center. The microwave blade tip clearance sensor works on principles that are very similar to a short-range radar system. The sensor sends a continuous microwave signal towards a target and measures the reflected signal. The phase difference of the reflected signal is directly proportional to the distance between the sensor and the target being measured. This type of sensor is beneficial in that it has the ability to operate at extremely high temperatures and is unaffected by contaminants that may be present in turbine engines. The use of microwave sensors for this application is a new concept. Techniques on calibrating the sensors along with installation effects are not well quantified as they are for other sensor technologies. Developing calibration techniques and evaluating installation effects are essential in using these sensors to make tip clearance and tip timing measurements. As a means of better understanding these issues, the microwave sensors were used on a benchtop calibration rig, a large axial vane fan, and a turbofan. Background on the microwave tip clearance sensor, an overview of their calibration, and the results from their use on the axial vane fan and the turbofan will be presented in this paper.

Testing of a Microwave Blade Tip Clearance Sensor at the NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Woike, Mark R.; Roeder, James W.; Hughes, Christopher E.; Bencic, Timothy J.

2009-01-01

The development of new active tip clearance control and structural health monitoring schemes in turbine engines and other types of rotating machinery requires sensors that are highly accurate and can operate in a high temperature environment. The use of a microwave sensor to acquire blade tip clearance and tip timing measurements is being explored at the NASA Glenn Research Center. The microwave blade tip clearance sensor works on principles that are very similar to a short range radar system. The sensor sends a continuous microwave signal towards a target and measures the reflected signal. The phase difference of the reflected signal is directly proportional to the distance between the sensor and the target being measured. This type of sensor is beneficial in that it has the ability to operate at extremely high temperatures and is unaffected by contaminants that may be present in turbine engines. The use of microwave sensors for this application is a new concept. Techniques on calibrating the sensors along with installation effects are not well quantified as they are for other sensor technologies. Developing calibration techniques and evaluating installation effects are essential in using these sensors to make tip clearance and tip timing measurements. As a means of better understanding these issues, the microwave sensors were used on a bench top calibration rig, a large axial vane fan, and a turbofan. Background on the microwave tip clearance sensor, an overview of their calibration, and the results from their use on the axial vane fan and the turbofan will be presented in this paper.

Evaluation of an Active Clearance Control System Concept

NASA Technical Reports Server (NTRS)

Steinetz, Bruce M.; Lattime, Scott B.; DeCastro, Jonathan A.; Oswald, Jay; Melcher, Kevin J.

2005-01-01

Reducing blade tip clearances through active tip clearance control in the high pressure turbine can lead to significant reductions in emissions and specific fuel consumption as well as dramatic improvements in operating efficiency and increased service life. Current engines employ scheduled cooling of the outer case flanges to reduce high pressure turbine tip clearances during cruise conditions. These systems have relatively slow response and do not use clearance measurement, thereby forcing cold build clearances to set the minimum clearances at extreme operating conditions (e.g., takeoff, reburst) and not allowing cruise clearances to be minimized due to the possibility of throttle transients (e.g., step change in altitude). In an effort to improve upon current thermal methods, a first generation mechanically-actuated active clearance control (ACC) system has been designed and fabricated. The system utilizes independent actuators, a segmented shroud structure, and clearance measurement feedback to provide fast and precise active clearance control throughout engine operation. Ambient temperature performance tests of this first generation ACC system assessed individual seal component leakage rates and both static and dynamic overall system leakage rates. The ability of the nine electric stepper motors to control the position of the seal carriers in both open- and closed-loop control modes for single and multiple cycles was investigated. The ability of the system to follow simulated engine clearance transients in closed-loop mode showed the system was able to track clearances to within a tight tolerance (0.001 in. error).

Evaluation of an Active Clearance Control System Concept

NASA Technical Reports Server (NTRS)

Steinetz, Bruce M.; Lattime, Scott B.; Taylor, Shawn; DeCastro, Jonathan A.; Oswald, Jay; Melcher, Kevin J.

2005-01-01

Reducing blade tip clearances through active tip clearance control in the high pressure turbine can lead to significant reductions in emissions and specific fuel consumption as well as dramatic improvements in operating efficiency and increased service life. Current engines employ scheduled cooling of the outer case flanges to reduce high pressure turbine tip clearances during cruise conditions. These systems have relatively slow response and do not use clearance measurement, thereby forcing cold build clearances to set the minimum clearances at extreme operating conditions (e.g., takeoff, reburst) and not allowing cruise clearances to be minimized due to the possibility of throttle transients (e.g., step change in altitude). In an effort to improve upon current thermal methods, a first generation mechanically-actuated active clearance control (ACC) system has been designed and fabricated. The system utilizes independent actuators, a segmented shroud structure, and clearance measurement feedback to provide fast and precise active clearance control throughout engine operation. Ambient temperature performance tests of this first generation ACC system assessed individual seal component leakage rates and both static and dynamic overall system leakage rates. The ability of the nine electric stepper motors to control the position of the seal carriers in both open- and closed-loop control modes for single and multiple cycles was investigated. The ability of the system to follow simulated engine clearance transients in closed-loop mode showed the system was able to track clearances to within a tight tolerance ( 0.001 in. error).

Numerical investigation of tip clearance cavitation in Kaplan runners

NASA Astrophysics Data System (ADS)

Nikiforova, K.; Semenov, G.; Kuznetsov, I.; Spiridonov, E.

2016-11-01

There is a gap between the Kaplan runner blade and the shroud that makes for a special kind of cavitation: cavitation in the tip leakage flow. Two types of cavitation caused by the presence of clearance gap are known: tip vortex cavitation that appears at the core of the rolled up vortex on the blade suction side and tip clearance cavitation that appears precisely in the gap between the blade tip edge and the shroud. In the context of this work numerical investigation of the model Kaplan runner has been performed taking into account variable tip clearance for several cavitation regimes. The focus is put on investigation of structure and origination of mechanism of cavitation in the tip leakage flow. Calculations have been performed with the help of 3-D unsteady numerical model for two-phase medium. Modeling of turbulent flow in this work has been carried out using full equations of Navier-Stokes averaged by Reynolds with correction for streamline curvature and system rotation. For description of this medium (liquid-vapor) simplification of Euler approach is used; it is based on the model of interpenetrating continuums, within the bounds of this two- phase medium considered as a quasi-homogeneous mixture with the common velocity field and continuous distribution of density for both phases. As a result, engineering techniques for calculation of cavitation conditioned by existence of tip clearance in model turbine runner have been developed. The detailed visualization of the flow was carried out and vortex structure on the suction side of the blade was reproduced. The range of frequency with maximum value of pulsation was assigned and maximum energy frequency was defined; it is based on spectral analysis of the obtained data. Comparison between numerical computation results and experimental data has been also performed. The location of cavitation zone has a good agreement with experiment for all analyzed regimes.

Axial compressor blade design for desensitization of aerodynamic performance and stability to tip clearance

NASA Astrophysics Data System (ADS)

Erler, Engin

Tip clearance flow is the flow through the clearance between the rotor blade tip and the shroud of a turbomachine, such as compressors and turbines. This flow is driven by the pressure difference across the blade (aerodynamic loading) in the tip region and is a major source of loss in performance and aerodynamic stability in axial compressors of modern aircraft engines. An increase in tip clearance, either temporary due to differential radial expansion between the blade and the shroud during transient operation or permanent due to engine wear or manufacturing tolerances on small blades, increases tip clearance flow and results in higher fuel consumption and higher risk of engine surge. A compressor design that can reduce the sensitivity of its performance and aerodynamic stability to tip clearance increase would have a major impact on short and long-term engine performance and operating envelope. While much research has been carried out on improving nominal compressor performance, little had been done on desensitization to tip clearance increase beyond isolated observations that certain blade designs such as forward chordwise sweep, seem to be less sensitive to tip clearance size increase. The current project aims to identify through a computational study the flow features and associated mechanisms that reduces sensitivity of axial compressor rotors to tip clearance size and propose blade design strategies that can exploit these results. The methodology starts with the design of a reference conventional axial compressor rotor followed by a parametric study with variations of this reference design through modification of the camber line and of the stacking line of blade profiles along the span. It is noted that a simple desensitization method would be to reduce the aerodynamic loading of the blade tip which would reduce the tip clearance flow and its proportional contribution to performance loss. However, with the larger part of the work on the flow done in this

A Study on the Requirements for Fast Active Turbine Tip Clearance Control Systems

NASA Technical Reports Server (NTRS)

DeCastro, Jonathan A.; Melcher, Kevin J.

2004-01-01

This paper addresses the requirements of a control system for active turbine tip clearance control in a generic commercial turbofan engine through design and analysis. The control objective is to articulate the shroud in the high pressure turbine section in order to maintain a certain clearance set point given several possible engine transient events. The system must also exhibit reasonable robustness to modeling uncertainties and reasonable noise rejection properties. Two actuators were chosen to fulfill such a requirement, both of which possess different levels of technological readiness: electrohydraulic servovalves and piezoelectric stacks. Identification of design constraints, desired actuator parameters, and actuator limitations are addressed in depth; all of which are intimately tied with the hardware and controller design process. Analytical demonstrations of the performance and robustness characteristics of the two axisymmetric LQG clearance control systems are presented. Takeoff simulation results show that both actuators are capable of maintaining the clearance within acceptable bounds and demonstrate robustness to parameter uncertainty. The present model-based control strategy was employed to demonstrate the tradeoff between performance, control effort, and robustness and to implement optimal state estimation in a noisy engine environment with intent to eliminate ad hoc methods for designing reliable control systems.

An optical fiber bundle sensor for tip clearance and tip timing measurements in a turbine rig.

PubMed

García, Iker; Beloki, Josu; Zubia, Joseba; Aldabaldetreku, Gotzon; Illarramendi, María Asunción; Jiménez, Felipe

2013-06-05

When it comes to measuring blade-tip clearance or blade-tip timing in turbines, reflective intensity-modulated optical fiber sensors overcome several traditional limitations of capacitive, inductive or discharging probe sensors. This paper presents the signals and results corresponding to the third stage of a multistage turbine rig, obtained from a transonic wind-tunnel test. The probe is based on a trifurcated bundle of optical fibers that is mounted on the turbine casing. To eliminate the influence of light source intensity variations and blade surface reflectivity, the sensing principle is based on the quotient of the voltages obtained from the two receiving bundle legs. A discrepancy lower than 3% with respect to a commercial sensor was observed in tip clearance measurements. Regarding tip timing measurements, the travel wave spectrum was obtained, which provides the average vibration amplitude for all blades at a particular nodal diameter. With this approach, both blade-tip timing and tip clearance measurements can be carried out simultaneously. The results obtained on the test turbine rig demonstrate the suitability and reliability of the type of sensor used, and suggest the possibility of performing these measurements in real turbines under real working conditions.

An Optical Fiber Bundle Sensor for Tip Clearance and Tip Timing Measurements in a Turbine Rig

PubMed Central

García, Iker; Beloki, Josu; Zubia, Joseba; Aldabaldetreku, Gotzon; Illarramendi, María Asunción; Jiménez, Felipe

2013-01-01

When it comes to measuring blade-tip clearance or blade-tip timing in turbines, reflective intensity-modulated optical fiber sensors overcome several traditional limitations of capacitive, inductive or discharging probe sensors. This paper presents the signals and results corresponding to the third stage of a multistage turbine rig, obtained from a transonic wind-tunnel test. The probe is based on a trifurcated bundle of optical fibers that is mounted on the turbine casing. To eliminate the influence of light source intensity variations and blade surface reflectivity, the sensing principle is based on the quotient of the voltages obtained from the two receiving bundle legs. A discrepancy lower than 3% with respect to a commercial sensor was observed in tip clearance measurements. Regarding tip timing measurements, the travel wave spectrum was obtained, which provides the average vibration amplitude for all blades at a particular nodal diameter. With this approach, both blade-tip timing and tip clearance measurements can be carried out simultaneously. The results obtained on the test turbine rig demonstrate the suitability and reliability of the type of sensor used, and suggest the possibility of performing these measurements in real turbines under real working conditions. PMID:23739163

Application of chromatic confocal displacement sensor in measurement of tip clearance

NASA Astrophysics Data System (ADS)

Bi, Chao; Li, Di; Fang, Jianguo; Zhang, Bin

2016-10-01

In the field of aeronautics, the tip clearance of rotor exerts a crucial influence on the performance of the aero engine. As defined as the radial distance between the top of the blade and the inner wall of the casing, the tip clearance of too large or small size will adversely affect the normal running of the engine. In order to realize accurate measurement of the tip clearance in a simple way, a non-contact measuring method by the chromatic confocal displacement sensor is proposed in the paper. The sensor possesses the advantages such as small volume, good signal-to-noise ratio, high accuracy and response frequency etc., which make it be widely used in engineering and industry. For testing the performance and potential application of the sensor, a simulation testing platform is established. In the platform, a simulation blisk is installed on the air bearing spindle and a chromatic confocal displacement sensor is fixed on the platform to measure the displacement variation of the blade tip, which can be used to characterize the variation of the tip clearance. In the simulation experiments, both of single and continuous measurement of the tip clearance of the 36 blades on the blisk is executed. As the results of experiments show, the chromatic confocal displacement sensor can meet the requirements of measuring task, in which both of high measuring efficiency and accuracy could be achieved. Therefore, the measuring method proposed in the paper can be utilized in the actual assembling sites of the aero engine.

Analysis, design, fabrication and testing of an optical tip clearance sensor. [turbocompressor blade tips

NASA Technical Reports Server (NTRS)

Poppel, G. L.; Marple, D. T. F.; Kingsley, J. D.

1981-01-01

Analyses and the design, fabrication, and testing of an optical tip clearance sensor with intended application in aircraft propulsion control systems are reported. The design of a sensor test rig, evaluation of optical sensor components at elevated temperatures, sensor design principles, sensor test results at room temperature, and estimations of sensor accuracy at temperatures of an aircraft engine environment are discussed. Room temperature testing indicated possible measurement accuracies of less than 12.7 microns (0.5 mils). Ways to improve performance at engine operating temperatures are recommended. The potential of this tip clearance sensor is assessed.

High-Speed, capacitance-based tip clearance sensing

NASA Astrophysics Data System (ADS)

Haase, W. C.; Haase, Z. S.

This paper discusses recent advances in tip clearance measurement systems for turbine engines using capacitive probes. Real time measurements of individual blade pulses are generated using wideband signal processing providing 3 dB bandwidths of typically 5 MHz. Subsequent mixed-signal processing circuitry provide real-time measurements of maximum, minimum, and average clearance with latencies of one blade-to-blade time interval. Both guarded and unguarded probe configurations are possible with the system. Calibration techniques provide high accuracy measurements.

Low-coherence interferometric tip-clearance probe

NASA Astrophysics Data System (ADS)

Kempe, Andreas; Schlamp, Stefan; Rösgen, Thomas; Haffner, Ken

2003-08-01

We propose an all-fiber, self-calibrating, economical probe that is capable of near-real-time, single-port, simultaneous blade-to-blade tip-clearance measurements with submillimeter accuracy (typically <100 μm, absolute) in the first stages of a gas turbine. Our probe relies on the interference between backreflected light from the blade tips during the 1-μs blade passage time and a frequency-shifted reference with variable time delay, making use of a low-coherence light source. A single optical fiber of arbitrary length connects the self-contained optics and electronics to the turbine.

Effect of rotor tip clearance and configuration on overall performance of a 12.77-centimeter tip diameter axial-flow turbine

NASA Technical Reports Server (NTRS)

Haas, J. E.; Kofskey, M. G.

1978-01-01

The rotor tip clearance was obtained by use of a recess in the casing above the rotor blades and also by use of a reduced blade height. For the recessed casing configuration, the optimum rotor blade height was found to be the one where the rotor tip diameter was equal to the stator tip diameter. The tip clearance loss associated with this optimum recessed casing configuration was less than that for the reduced blade height configuration.

Shape memory alloy adaptive control of gas turbine engine compressor blade tip clearance

NASA Astrophysics Data System (ADS)

Schetky, Lawrence M.; Steinetz, Bruce M.

1998-06-01

The ambient air ingested through the inlet of a gas turbine is first compressed by an axial compressor followed by further compression in a centrifugal compressor and then fed into the combustion chamber where ignition and expansion take place to produce the engine thrust. The axial compressor typically has five or more stages which consist of revolving blades and stators and the overall performance of the turbine is strongly affected by the compressor efficiency. When the turbine is turned on, to accommodate the rapid initial increase in the compressor blade length due to centrifugal force, the cold turbine has a built in clearance between the turbine blade tip and the casing. As the turbine reached its operating temperature there is a further increase in the blade length due to thermal expansion and, at the same time, the diameter of the casing increases. The net result is that when these various components have reached their equilibrium temperatures, the initial cold build clearance is reduced, but there remains a residual clearance. The magnitude of this clearance has a direct effect on the compressor efficiency and can be stated as: Δη/Δ CLR equals 0.5 where η is efficiency and CLR is the tip clearance. The concept of adaptive tip clearance control is based on the ability of a shape memory alloy ring to shrink to a predetermined diameter when heated to the temperature of a particular stage, and thus reducing the tip clearance. The ring is fabricated from a CuAlNi shape memory alloy and is mounted in the casing so as to be coaxial with the rotating blades of the particular stage. When cold, the ring dimensions are such as to provide the required cold build clearance, but when at operating temperature the reduced diameter creates a very small tip clearance. The clearance provided by this concept is much smaller than the clearance normally obtained for a turbine of the size being studied.

Axial compressor gas path design for desensitization of aerodynamic performance and stability to tip clearance

NASA Astrophysics Data System (ADS)

Cevik, Mert

Tip clearance is the necessary small gap left between the moving rotor tip and stationary shroud of a turbomachine. In a compressor, the pressure driven flow through this gap, called tip clearance flow, has a major and generally detrimental impact on compressor performance (pressure ratio and efficiency) and aerodynamic stability (stall margin). The increase in tip clearance, either temporary during transient engine operations or permanent from wear, leads to a drop in compressor performance and aerodynamic stability which results in a fuel consumption increase and a reduced operating envelope for a gas turbine engine. While much research has looked into increasing compressor performance and stall margin at the design (minimum or nominal) tip clearance, very little attention has been paid for reducing the sensitivity of these parameters to tip clearance size increase. The development of technologies that address this issue will lead to aircraft engines whose performance and operating envelope are more robust to operational demands and wear. The current research is the second phase of a research programme to develop design strategies to reduce the sensitivity of axial compressor performance and aerodynamic stability to tip clearance. The first phase had focused on blade design strategies and had led to the discovery and explanation of two flow features that reduces tip sensitivity, namely increased incoming meridional momentum in the rotor tip region and reduction/elimination of double leakage. Double leakage is the flow that exits one tip clearance and enters the tip clearance of the adjacent blade instead of convecting downstream out of the rotor passage. This flow was shown to be very detrimental to compressor performance and stall margin. Two rotor design strategies involving sweep and tip stagger reduction were proposed and shown by CFD simulations to exploit these features to reduce sensitivity. As the second phase, the objectives of the current research

A Novel Approach for Reducing Rotor Tip-Clearance Induced Noise in Turbofan Engines

NASA Technical Reports Server (NTRS)

Khorrami, Mehdi R.; Li, Fei; Choudhari, Meelan

2001-01-01

Rotor tip-clearance induced noise, both in the form of rotor self noise and rotor-stator interaction noise , constitutes a significant component of total fan noise. Innovative yet cost effective techniques to suppress rotor-generated noise are, therefore, of foremost importance for improving the noise signature of turbofan engines. To that end, the feasibility of a passive porous treatment strategy to positively modify the tip-clearance flow field is addressed. The present study is focused on accurate viscous flow calculations of the baseline and the treated rotor flow fields. Detailed comparison between the computed baseline solution and experimental measurements shows excellent agreement. Tip-vortex structure, trajectory, strength, and other relevant aerodynamic quantities are extracted from the computed database. Extensive comparison between the untreated and treated tip-clearance flow fields is performed. The effectiveness of the porous treatment for altering the rotor-tip vortex flow field in general and reducing the intensity of the tip vortex, in particular, is demonstrated. In addition, the simulated flow field for the treated tip clearly shows that substantial reduction in the intensity of both the shear layer roll-up and boundary layer separation on the wall is achieved.

Rotating coherent flow structures as a source for narrowband tip clearance noise from axial fans

NASA Astrophysics Data System (ADS)

Zhu, Tao; Lallier-Daniels, Dominic; Sanjosé, Marlène; Moreau, Stéphane; Carolus, Thomas

2018-03-01

Noise from axial fans typically increases significantly as the tip clearance is increased. In addition to the broadband tip clearance noise at the design flow rate, narrowband humps also associated with the tip flow are observed in the far-field acoustic spectra at lower flow rate. In this study, both experimental and numerical methods are used to shed more light on the noise generation mechanism of this narrowband tip clearance noise and provide a unified description of this source. Unsteady aeroacoustic predictions with the Lattice-Boltzmann Method (LBM) are successfully compared with experiment. Such a validation allows using LBM data to conduct a detailed modal analysis of the pressure field for detecting rotating coherent flow structures which might be considered as noise sources. As previously found in ring fans the narrowband humps in the far-field noise spectra are found to be related to the tip clearance noise that is generated by an interaction of coherent flow structures present in the tip region with the leading edge of the impeller blades. The visualization of the coherent structures shows that they are indeed part of the unsteady tip clearance vortex structures. They are hidden in a complex, spatially and temporally inhomogeneous flow field, but can be recovered by means of appropriate filtering techniques. Their pressure trace corresponds to the so-called rotational instability identified in previous turbomachinery studies, which brings a unified picture of this tip-noise phenomenon for the first time.

On the development of a magnetoresistive sensor for blade tip timing and blade tip clearance measurement systems

NASA Astrophysics Data System (ADS)

Tomassini, R.; Rossi, G.; Brouckaert, J.-F.

2014-05-01

The accurate control of the gap between static and rotating components is vital to preserve the mechanical integrity and ensure a correct functioning of any rotating machinery. Moreover, tip leakage above the airfoil tip results in relevant aerodynamic losses. One way to measure and to monitor blade tip gaps is by the so-called Blade Tip Clearance (BTC) technique. Another fundamental phenomenon to control in the turbomachines is the vibration of the blades. For more than half a century, this has been performed by installing strain gauges on the blades and using telemetry to transmit the signals. The Blade Tip Timing (BTT) technique, (i.e. measuring the blade time of arrival from the casing at different angular locations with proximity sensors) is currently being adopted by all manufacturers as a replacement for the classical strain gauge technique because of its non-intrusive character. This paper presents a novel magnetoresistive sensor for blade tip timing and blade tip clearance systems, which offers high temporal and high spatial resolution simultaneously. The sensing element adopted is a Wheatstone bridge of Permalloy elements. The principle of the sensor is based on the variation of magnetic field at the passage of ferromagnetic objects. Two different configurations have been realized, a digital and an analogue sensor. Measurements of tip clearance have been performed in an high speed compressor and the calibration curve is reported. Measurements of blade vibration have been carried out in a dedicated calibration bench; results are presented and discussed. The magnetoresistive sensor is characterized by high repeatability, low manufacturing costs and measurement accuracy in line with the main probes used in turbomachinery testing. The novel sensor has great potential and is capable of fulfilling the requirements for a simultaneous BTC and BTT measurement system.

Ramp-integration technique for capacitance-type blade-tip clearance measurement

NASA Astrophysics Data System (ADS)

Sarma, Garimella R.; Barranger, John P.

The analysis of a proposed new technique for capacitance type blade tip clearance measurement is presented. The capacitance between the blade tip and a mounted capacitance electrode within a guard ring forms one of the feedback elements of a high speed operational amplifier. The differential equation governing the operational amplifier circuit is formulated and solved for two types of inputs to the amplifier - a constant voltage and a ramp. The resultant solution shows an output that contains a term that is proportional to the derivative of the product of the input voltage and the time constant of the feedback network. The blade tip clearance capacitance is obtained by subtracting the output of a balancing reference channel followed by integration. The proposed sampled data algorithm corrects for environmental effects and varying rotor speeds on-line, making the system suitable for turbine instrumentation. System requirements, block diagrams, and a typical application are included.

Ramp-integration technique for capacitance-type blade-tip clearance measurement

NASA Astrophysics Data System (ADS)

Sarma, G. R.; Barranger, J. P.

1986-05-01

The analysis of a proposed new technique for capacitance type blade tip clearance measurement is presented. The capacitance between the blade tip and a mounted capacitance electrode within a guard ring forms one of the feedback elements of a high speed operational amplifier. The differential equation governing the operational amplifier circuit is formulated and solved for two types of inputs to the amplifier - a constant voltage and a ramp. The resultant solutions shows an output that contains a term that is proportional to the derivative of the product of the input voltage and the time constant of the feedback network. The blade tip clearance capacitance is obtained by subtracting the output of a balancing reference channel followed by integration. The proposed sampled data algorithm corrects the environmental effects and varying rotor speeds on-line, making the system suitable for turbine instrumentation. System requirements, block diagrams, and typical application are included.

Ramp-integration technique for capacitance-type blade-tip clearance measurement

NASA Technical Reports Server (NTRS)

Sarma, Garimella R.; Barranger, John P.

1986-01-01

The analysis of a proposed new technique for capacitance type blade tip clearance measurement is presented. The capacitance between the blade tip and a mounted capacitance electrode within a guard ring forms one of the feedback elements of a high speed operational amplifier. The differential equation governing the operational amplifier circuit is formulated and solved for two types of inputs to the amplifier - a constant voltage and a ramp. The resultant solution shows an output that contains a term that is proportional to the derivative of the product of the input voltage and the time constant of the feedback network. The blade tip clearance capacitance is obtained by subtracting the output of a balancing reference channel followed by integration. The proposed sampled data algorithm corrects for environmental effects and varying rotor speeds on-line, making the system suitable for turbine instrumentation. System requirements, block diagrams, and a typical application are included.

Ramp-integration technique for capacitance-type blade-tip clearance measurement

NASA Technical Reports Server (NTRS)

Sarma, G. R.; Barranger, J. P.

1986-01-01

The analysis of a proposed new technique for capacitance type blade tip clearance measurement is presented. The capacitance between the blade tip and a mounted capacitance electrode within a guard ring forms one of the feedback elements of a high speed operational amplifier. The differential equation governing the operational amplifier circuit is formulated and solved for two types of inputs to the amplifier - a constant voltage and a ramp. The resultant solutions shows an output that contains a term that is proportional to the derivative of the product of the input voltage and the time constant of the feedback network. The blade tip clearance capacitance is obtained by subtracting the output of a balancing reference channel followed by integration. The proposed sampled data algorithm corrects the environmental effects and varying rotor speeds on-line, making the system suitable for turbine instrumentation. System requirements, block diagrams, and typical application are included.

Benefits of Improved HP Turbine Active Clearance Control

NASA Technical Reports Server (NTRS)

Ruiz, Rafael; Albers, Bob; Sak, Wojciech; Seitzer, Ken; Steinetz, Bruce M.

2007-01-01

As part of the NASA Propulsion 21 program, GE Aircraft Engines was contracted to develop an improved high pressure turbine(HPT) active clearance control (ACC) system. The system is envisioned to minimize blade tip clearances to improve HPT efficiency throughout the engine operation range simultaneously reducing fuel consumption and emissions.

Experimental and computational investigation of the tip clearance flow in a transonic axial compressor rotor

NASA Astrophysics Data System (ADS)

Suder, Kenneth L.; Celestina, Mark L.

1995-06-01

Experimental and computational techniques are used to investigate tip clearance flows in a transonic axial compressor rotor at design and part speed conditions. Laser anemometer data acquired in the endwall region are presented for operating conditions near peak efficiency and near stall at 100% design speed and at near peak efficiency at 60% design speed. The role of the passage shock/leakage vortex interaction in generating endwall blockage is discussed. As a result of the shock/vortex interaction at design speed, the radial influence of the tip clearance flow extends to 20 times the physical tip clearance height. At part speed, in the absence of the shock, the radial extent is only 5 times the tip clearance height. Both measurements and analysis indicate that under part-speed operating conditions a second vortex, which does not originate from the tip leakage flow, forms in the endwall region within the blade passage and exits the passage near midpitch. Mixing of the leakage vortex with primary flow downstream of the rotor at both design and part speed conditions is also discussed.

Experimental and Computational Investigation of the Tip Clearance Flow in a Transonic Axial Compressor Rotor

NASA Technical Reports Server (NTRS)

Suder, Kenneth L.; Celestina, Mark L.

1995-01-01

Experimental and computational techniques are used to investigate tip clearance flows in a transonic axial compressor rotor at design and part speed conditions. Laser anemometer data acquired in the endwall region are presented for operating conditions near peak efficiency and near stall at 100% design speed and at near peak efficiency at 60% design speed. The role of the passage shock/leakage vortex interaction in generating endwall blockage is discussed. As a result of the shock/vortex interaction at design speed, the radial influence of the tip clearance flow extends to 20 times the physical tip clearance height. At part speed, in the absence of the shock, the radial extent is only 5 times the tip clearance height. Both measurements and analysis indicate that under part-speed operating conditions a second vortex, which does not originate from the tip leakage flow, forms in the endwall region within the blade passage and exits the passage near midpitch. Mixing of the leakage vortex with primary flow downstream of the rotor at both design and part speed conditions is also discussed.

Rotor tip clearance effects on overall and blade-element performance of axial-flow transonic fan stage

NASA Technical Reports Server (NTRS)

Moore, R. D.

1982-01-01

The effects of tip clearance on the overall and blade-element performance of an axial-flow transonic fan stage are presented. The 50-centimeter-diameter fan was tested at four tip clearances (nonrotating) from 0.061 to 0.178 centimeter. The calculated radial growth of the blades was 0.040 centimeter at design conditions. The decrease in overall stage performance with increasing clearance is attributed to the loss in rotor performance. For the rotor the effects of clearance on performance parameters extended to about 70 percent of blade span from the tip. The stage still margin based on an assumed operating line decreased from 15.3 to 0 percent as the clearance increased from 0.061 to 0.178 centimeter.

Effects of Tip Clearance and Casing Recess on Heat Transfer and Stage Efficiency in Axial Turbines

NASA Technical Reports Server (NTRS)

Ameri, A. A.; Steinthorsson, E.; Rigby, David L.

1998-01-01

Calculations were performed to assess the effect of the tip leakage flow on the rate of heat transfer to blade, blade tip and casing. The effect on exit angle and efficiency was also examined. Passage geometries with and without casing recess were considered. The geometry and the flow conditions of the GE-E 3 first stage turbine, which represents a modem gas turbine blade were used for the analysis. Clearance heights of 0%, 1%, 1.5% and 3% of the passage height were considered. For the two largest clearance heights considered, different recess depths were studied. There was an increase in the thermal load on all the heat transfer surfaces considered due to enlargement of the clearance gap. Introduction of recessed casing resulted in a drop in the rate of heat transfer on the pressure side but the picture on the suction side was found to be more complex for the smaller tip clearance height considered. For the larger tip clearance height the effect of casing recess was an orderly reduction in the suction side heat transfer as the casing recess height was increased. There was a marked reduction of heat load and peak values on the blade tip upon introduction of casing recess, however only a small reduction was observed on the casing itself. It was reconfirmed that there is a linear relationship between the efficiency and the tip gap height. It was also observed that the recess casing has a small effect on the efficiency but can have a moderating effect on the flow underturning at smaller tip clearances.

Tip clearance effects on loads and performances of semi-open impeller centrifugal pumps at different specific speeds

NASA Astrophysics Data System (ADS)

Boitel, G.; Fedala, D.; Myon, N.

2016-11-01

Relevant industrial standards or customer's specifications could strictly forbid any device adjusting the axial rotor/stator position, so that tip clearance between semi-open impeller and casing might become a result of the pump machining tolerances and assembling process, leading to big tip clearance variations compared to its nominal value. Consequently, large disparities of global performances (head, power, efficiency) and axial loads are observed with high risk of both specifications noncompliance and bearing damages. This work aims at quantifying these variations by taking into account tip clearance value and pump specific speed. Computational Fluid Dynamics is used to investigate this phenomenon by means of steady simulations led on a semi-open centrifugal pump numerical model including secondary flows, based on a k-omega SST turbulence model. Four different specific speed pump sizes are simulated (from 8 to 50, SI units), with three tip clearances for each size on a wide flow range (from 40% to 120% of the best efficiency point). The numerical results clearly show that head, power and efficiency increase as the tip clearance decreases for the whole flow range. This effect is more significant when the specific speed is low. Meanwhile, the resulting axial thrust on the impeller is very sensitive to the tip clearance and can even lead to direction inversion.

Recommendations for Achieving Accurate Numerical Simulation of Tip Clearance Flows in Transonic Compressor Rotors

NASA Technical Reports Server (NTRS)

VanZante, Dale E.; Strazisar, Anthony J.; Wood, Jerry R,; Hathaway, Michael D.; Okiishi, Theodore H.

2000-01-01

The tip clearance flows of transonic compressor rotors are important because they have a significant impact on rotor and stage performance. While numerical simulations of these flows are quite sophisticated. they are seldom verified through rigorous comparisons of numerical and measured data because these kinds of measurements are rare in the detail necessary to be useful in high-speed machines. In this paper we compare measured tip clearance flow details (e.g. trajectory and radial extent) with corresponding data obtained from a numerical simulation. Recommendations for achieving accurate numerical simulation of tip clearance flows are presented based on this comparison. Laser Doppler Velocimeter (LDV) measurements acquired in a transonic compressor rotor, NASA Rotor 35, are used. The tip clearance flow field of this transonic rotor was simulated using a Navier-Stokes turbomachinery solver that incorporates an advanced k-epsilon turbulence model derived for flows that are not in local equilibrium. Comparison between measured and simulated results indicates that simulation accuracy is primarily dependent upon the ability of the numerical code to resolve important details of a wall-bounded shear layer formed by the relative motion between the over-tip leakage flow and the shroud wall. A simple method is presented for determining the strength of this shear layer.

Tip Clearance Control Using Plasma Actuators

DTIC Science & Technology

2007-03-01

Clearance Control Using Plasma Actuators 4 posed by Denton (1993). A number of investigators have used partial shrouds, or " winglet " designs to...main molded blade with a span of 3.42 in., a removable molded blade segment with a span of 0.1875 in., and removable blade tip winglets made of glass...segment and the main blade to vary the distance between the blade end and the front wall of the cascade section. The winglets were machined using a

Test Rig for Evaluating Active Turbine Blade Tip Clearance Control Concepts

NASA Technical Reports Server (NTRS)

Lattime, Scott B.; Steinetz, Bruce M.; Robbie, Malcolm G.; Erker, Arthur H.

2004-01-01

The objectives of the research presented in this viewgraph presentation are to 1) Design a mechanical ACC system for HPT tip seal clearance management; 2) Design a test rig to evaluate ACC system concepts. We have focused our efforts on designing mechanical ACC systems that articulate the seal shroud via mechanical linkages connected to actuators that reside outside the extreme environment of the HPT. We opted for this style of design due to a lack of high temperature/low profile actuators that are presently available. We have also selected multiple hydraulic actuators for this first generation ACC system. Fuel-draulic actuators are already a well established technology.

Cold-air performance of a 12.766-centimeter-tip-diameter axial-flow cooled turbine. 3: Effect of rotor tip clearance on overall performance of a solid blade configuration

NASA Technical Reports Server (NTRS)

Haas, J. E.; Kofskey, M. G.

1977-01-01

Two tip clearance configurations, one with a recess in the casing and the other with a reduced rotor blade height, were investigated at design equivalent speed over a range of tip clearance from about 2.0 to 5.0 percent of the stator blade height. The optimum configuration with a recess in the casing was the one where the rotor tip diameter was equal to the stator tip diameter (zero blade extension). For this configuration there was an approximate 1.5 percent decrease in total efficiency for an increase in tip clearance of 1 percent of stator blade height. For the reduced blade height configurations there was an approximate 2.0 percent decrease in total efficiency for an increase in tip clearance of 1 percent of stator blade height.

Investigation of Unsteady Tip Clearance Flow in a Low-Speed One and Half Stage Axial Compressor with LES And PIV

NASA Technical Reports Server (NTRS)

Hah, Chunill; Hathaway, Michael; Katz, Joseph; Tan, David

2015-01-01

The primary focus of this paper is to investigate how a rotor's unsteady tip clearance flow structure changes in a low speed one and half stage axial compressor when the rotor tip gap size is increased from 0.5 mm (0.49% of rotor tip blade chord, 2% of blade span) to 2.4 mm (2.34% chord, 4% span) at the design condition are investigated. The changes in unsteady tip clearance flow with the 0.62 % tip gap as the flow rate is reduced to near stall condition are also investigated. A Large Eddy Simulation (LES) is applied to calculate the unsteady flow field at these three flow conditions. Detailed Stereoscopic PIV (SPIV) measurements of the current flow fields were also performed at the Johns Hopkins University in a refractive index-matched test facility which renders the compressor blades and casing optically transparent. With this setup, the unsteady velocity field in the entire flow domain, including the flow inside the tip gap, can be measured. Unsteady tip clearance flow fields from LES are compared with the PIV measurements and both LES and PIV results are used to study changes in tip clearance flow structures. The current study shows that the tip clearance vortex is not a single structure as traditionally perceived. The tip clearance vortex is formed by multiple interlaced vorticities. Therefore, the tip clearance vortex is inherently unsteady. The multiple interlaced vortices never roll up to form a single structure. When phased-averaged, the tip clearance vortex appears as a single structure. When flow rate is reduced with the same tip gap, the tip clearance vortex rolls further upstream and the tip clearance vortex moves further radially inward and away from the suction side of the blade. When the tip gap size is increased at the design flow condition, the overall tip clearance vortex becomes stronger and it stays closer to the blade suction side and the vortex core extends all the way to the exit of the blade passage. Measured and calculated unsteady flow

Turbine-blade tip clearance and tip timing measurements using an optical fiber bundle sensor

NASA Astrophysics Data System (ADS)

Garcia, Iker; Beloki, Josu; Zubia, Joseba; Durana, Gaizka; Aldabaldetreku, Gotzon

2013-04-01

Traditional limitations of capacitive, inductive or discharging probe sensor for tip timing and tip clearance measurements are overcome by reflective intensity modulated optical fiber sensors. This paper presents the signals and results corresponding to a one stage turbine rig which rotor has 146 blades, obtained from a transonic wind-tunnel test. The probe is based on a trifurcated bundle of optical fibers that is mounted on turbine casing. It is composed of a central illuminating fiber that guides the light from a laser to the turbine blade, and two concentric rings of receiving fibers that collect the reflected light. Two photodetectors turn this reflected light signal from the receiving rings into voltage. The electrical signals are acquired and saved by a high-sample-rate oscilloscope. In tip clearance calculations the ratio of the signals provided by each ring of receiving fibers is evaluated and translated into distance. In the case of tip timing measurements, only one of the signals is considered to get the arrival time of the blade. The differences between the real and theoretical arrival times of the blades are used to obtain the deflections amplitude. The system provides the travelling wave spectrum, which presents the average vibration amplitude of the blades at a certain nodal diameter. The reliability of the results in the turbine rig testing facilities suggests the possibility of performing these measurements in real turbines under real working conditions.

Improved Temperature Dynamic Model of Turbine Subcomponents for Facilitation of Generalized Tip Clearance Control

NASA Technical Reports Server (NTRS)

Kypuros, Javier A.; Colson, Rodrigo; Munoz, Afredo

2004-01-01

This paper describes efforts conducted to improve dynamic temperature estimations of a turbine tip clearance system to facilitate design of a generalized tip clearance controller. This work builds upon research previously conducted and presented in and focuses primarily on improving dynamic temperature estimations of the primary components affecting tip clearance (i.e. the rotor, blades, and casing/shroud). The temperature profiles estimated by the previous model iteration, specifically for the rotor and blades, were found to be inaccurate and, more importantly, insufficient to facilitate controller design. Some assumptions made to facilitate the previous results were not valid, and thus improvements are presented here to better match the physical reality. As will be shown, the improved temperature sub- models, match a commercially validated model and are sufficiently simplified to aid in controller design.

A Reduced Model for Prediction of Thermal and Rotational Effects on Turbine Tip Clearance

NASA Technical Reports Server (NTRS)

Kypuros, Javier A.; Melcher, Kevin J.

2003-01-01

This paper describes a dynamic model that was developed to predict changes in turbine tip clearance the radial distance between the end of a turbine blade and the abradable tip seal. The clearance is estimated by using a first principles approach to model the thermal and mechanical effects of engine operating conditions on the turbine sub-components. These effects are summed to determine the resulting clearance. The model is demonstrated via a ground idle to maximum power transient and a lapse-rate takeoff transient. Results show the model demonstrates the expected pinch point behavior. The paper concludes by identifying knowledge gaps and suggesting additional research to improve the model.

On the development of a magnetoresistive sensor for blade tip timing and blade tip clearance measurement systems.

PubMed

Tomassini, R; Rossi, G; Brouckaert, J-F

2016-10-01

A simultaneous blade tip timing (BTT) and blade tip clearance (BTC) measurement system enables the determination of turbomachinery blade vibrations and ensures the monitoring of the existing running gaps between the blade tip and the casing. This contactless instrumentation presents several advantages compared to the well-known telemetry system with strain gauges, at the cost of a more complex data processing procedure. The probes used can be optical, capacitive, eddy current as well as microwaves, everyone with its dedicated electronics and many existing different signal processing algorithms. Every company working in this field has developed its own processing method and sensor technology. Hence, repeating the same test with different instrumentations, the answer is often different. Moreover, rarely it is possible to achieve reliability for in-service measurements. Developments are focused on innovative instrumentations and a common standard. This paper focuses on the results achieved using a novel magnetoresistive sensor for simultaneous tip timing and tip clearance measurements. The sensor measurement principle is described. The sensitivity to gap variation is investigated. In terms of measurement of vibrations, experimental investigations were performed at the Air Force Institute of Technology (ITWL, Warsaw, Poland) in a real aeroengine and in the von Karman Institute (VKI) R2 compressor rig. The advantages and limitations of the magnetoresistive probe for turbomachinery testing are highlighted.

On the development of a magnetoresistive sensor for blade tip timing and blade tip clearance measurement systems

NASA Astrophysics Data System (ADS)

Tomassini, R.; Rossi, G.; Brouckaert, J.-F.

2016-10-01

A simultaneous blade tip timing (BTT) and blade tip clearance (BTC) measurement system enables the determination of turbomachinery blade vibrations and ensures the monitoring of the existing running gaps between the blade tip and the casing. This contactless instrumentation presents several advantages compared to the well-known telemetry system with strain gauges, at the cost of a more complex data processing procedure. The probes used can be optical, capacitive, eddy current as well as microwaves, everyone with its dedicated electronics and many existing different signal processing algorithms. Every company working in this field has developed its own processing method and sensor technology. Hence, repeating the same test with different instrumentations, the answer is often different. Moreover, rarely it is possible to achieve reliability for in-service measurements. Developments are focused on innovative instrumentations and a common standard. This paper focuses on the results achieved using a novel magnetoresistive sensor for simultaneous tip timing and tip clearance measurements. The sensor measurement principle is described. The sensitivity to gap variation is investigated. In terms of measurement of vibrations, experimental investigations were performed at the Air Force Institute of Technology (ITWL, Warsaw, Poland) in a real aeroengine and in the von Karman Institute (VKI) R2 compressor rig. The advantages and limitations of the magnetoresistive probe for turbomachinery testing are highlighted.

Structural Health Monitoring on Turbine Engines Using Microwave Blade Tip Clearance Sensors

NASA Technical Reports Server (NTRS)

Woike, Mark; Abdul-Aziz, Ali; Clem, Michelle

2014-01-01

The ability to monitor the structural health of the rotating components, especially in the hot sections of turbine engines, is of major interest to aero community in improving engine safety and reliability. The use of instrumentation for these applications remains very challenging. It requires sensors and techniques that are highly accurate, are able to operate in a high temperature environment, and can detect minute changes and hidden flaws before catastrophic events occur. The National Aeronautics and Space Administration (NASA) has taken a lead role in the investigation of new sensor technologies and techniques for the in situ structural health monitoring of gas turbine engines. As part of this effort, microwave sensor technology has been investigated as a means of making high temperature non-contact blade tip clearance, blade tip timing, and blade vibration measurements for use in gas turbine engines. This paper presents a summary of key results and findings obtained from the evaluation of two different types of microwave sensors that have been investigated for use possible in structural health monitoring applications. The first is a microwave blade tip clearance sensor that has been evaluated on a large scale Axial Vane Fan, a subscale Turbofan, and more recently on sub-scale turbine engine like disks. The second is a novel microwave based blade vibration sensor that was also used in parallel with the microwave blade tip clearance sensors on the experiments with the sub-scale turbine engine disks.

Structural health monitoring on turbine engines using microwave blade tip clearance sensors

NASA Astrophysics Data System (ADS)

Woike, Mark; Abdul-Aziz, Ali; Clem, Michelle

2014-04-01

The ability to monitor the structural health of the rotating components, especially in the hot sections of turbine engines, is of major interest to the aero community in improving engine safety and reliability. The use of instrumentation for these applications remains very challenging. It requires sensors and techniques that are highly accurate, are able to operate in a high temperature environment, and can detect minute changes and hidden flaws before catastrophic events occur. The National Aeronautics and Space Administration (NASA) has taken a lead role in the investigation of new sensor technologies and techniques for the in situ structural health monitoring of gas turbine engines. As part of this effort, microwave sensor technology has been investigated as a means of making high temperature non-contact blade tip clearance, blade tip timing, and blade vibration measurements for use in gas turbine engines. This paper presents a summary of key results and findings obtained from the evaluation of two different types of microwave sensors that have been investigated for possible use in structural health monitoring applications. The first is a microwave blade tip clearance sensor that has been evaluated on a large scale Axial Vane Fan, a subscale Turbofan, and more recently on sub-scale turbine engine like disks. The second is a novel microwave based blade vibration sensor that was also used in parallel with the microwave blade tip clearance sensors on the same experiments with the sub-scale turbine engine disks.

Robust Optimization Design for Turbine Blade-Tip Radial Running Clearance using Hierarchically Response Surface Method

NASA Astrophysics Data System (ADS)

Zhiying, Chen; Ping, Zhou

2017-11-01

Considering the robust optimization computational precision and efficiency for complex mechanical assembly relationship like turbine blade-tip radial running clearance, a hierarchically response surface robust optimization algorithm is proposed. The distribute collaborative response surface method is used to generate assembly system level approximation model of overall parameters and blade-tip clearance, and then a set samples of design parameters and objective response mean and/or standard deviation is generated by using system approximation model and design of experiment method. Finally, a new response surface approximation model is constructed by using those samples, and this approximation model is used for robust optimization process. The analyses results demonstrate the proposed method can dramatic reduce the computational cost and ensure the computational precision. The presented research offers an effective way for the robust optimization design of turbine blade-tip radial running clearance.

Investigation of tip clearance flow physics in axial flow turbine rotors

NASA Astrophysics Data System (ADS)

Xiao, Xinwen

In axial turbines, the tip clearance between casing wall and rotating blades results in a tip leakage flow, which significantly affects loss production, heat protection, vibration and noise. It is important to minimize these effects for a better turbine engine performance and higher reliability. Most of previous efforts were concentrated on turbine cascades that however may not completely and correctly simulate the flow physics in practical turbine rotors. An investigation has to be performed in turbine rotors to reveal the real tip leakage flow physics in order to provide a scientific basis for minimizing its effects. This is the objective of this thesis research. The three dimensional flow field near the end wall/tip clearance region in a turbine rotor has been investigated experimentally, complemented by a numerical simulation to study the influences of inlet turbulence intensities on the development of the tip leakage flow. The experimental investigation is carried out in a modern unshrouded high pressure turbine stage. The survey region covers 20% span near the end wall, and extends axially from 10% chord upstream of the leading edge, through the rotor passage, and to 20% chord downstream of the trailing edge. It has been found that the tip leakage effects extend only to the surveyed region. The three dimensional LDV technique is used to measure the velocity and turbulence field upstream of the rotor, inside the rotor passage, and near the trailing edge. The static pressure on blade surfaces is surveyed from the rotating frame. The transient pressure on the casing wall is measured using a dynamic pressure sensor with a shaft encoder. A rotating Five Hole Probe is employed to measure the losses as well as the pressure and the three dimensional velocity field at 20% chord downstream of the rotor. The unsteady flow field is also investigated at this location by using a slanted single-element Hot Wire technique. The physics of the tip leakage flow and vortex in

An on-line calibration technique for improved blade by blade tip clearance measurement

NASA Astrophysics Data System (ADS)

Sheard, A. G.; Westerman, G. C.; Killeen, B.

A description of a capacitance-based tip clearance measurement system which integrates a novel technique for calibrating the capacitance probe in situ is presented. The on-line calibration system allows the capacitance probe to be calibrated immediately prior to use, providing substantial operational advantages and maximizing measurement accuracy. The possible error sources when it is used in service are considered, and laboratory studies of performance to ascertain their magnitude are discussed. The 1.2-mm diameter FM capacitance probe is demonstrated to be insensitive to variations in blade tip thickness from 1.25 to 1.45 mm. Over typical compressor blading the probe's range was four times the variation in blade to blade clearance encountered in engine run components.

Investigation of Unsteady Flow Field in a Low-Speed One and a Half Stage Axial Compressor. Part 2; Effects of Tip Gap Size On the Tip Clearance Flow Structure at Near Stall Operation

NASA Technical Reports Server (NTRS)

Hah, Chunill; Hathaway, Michael; Katz, Joseph

2014-01-01

The primary focus of this paper is to investigate the effect of rotor tip gap size on how the rotor unsteady tip clearance flow structure changes in a low speed one and half stage axial compressor at near stall operation (for example, where maximum pressure rise is obtained). A Large Eddy Simulation (LES) is applied to calculate the unsteady flow field at this flow condition with both a small and a large tip gaps. The numerically obtained flow fields at the small clearance matches fairly well with the available initial measurements obtained at the Johns Hopkins University with 3-D unsteady PIV in an index-matched test facility which renders the compressor blades and casing optically transparent. With this setup, the unsteady velocity field in the entire flow domain, including the flow inside the tip gap, can be measured. The numerical results are also compared with previously published measurements in a low speed single stage compressor (Maerz et al. [2002]). The current study shows that, with the smaller rotor tip gap, the tip clearance vortex moves to the leading edge plane at near stall operating condition, creating a nearly circumferentially aligned vortex that persists around the entire rotor. On the other hand, with a large tip gap, the clearance vortex stays inside the blade passage at near stall operation. With the large tip gap, flow instability and related large pressure fluctuation at the leading edge are observed in this one and a half stage compressor. Detailed examination of the unsteady flow structure in this compressor stage reveals that the flow instability is due to shed vortices near the leading edge, and not due to a three-dimensional separation vortex originating from the suction side of the blade, which is commonly referred to during a spike-type stall inception. The entire tip clearance flow is highly unsteady. Many vortex structures in the tip clearance flow, including the sheet vortex system near the casing, interact with each other. The

Removable inner turbine shell with bucket tip clearance control

DOEpatents

Sexton, Brendan F.; Knuijt, Hans M.; Eldrid, Sacheverel Q.; Myers, Albert; Coneybeer, Kyle E.; Johnson, David Martin; Kellock, Iain R.

2000-01-01

A turbine includes a plurality of inner shell sections mounting first and second stage nozzle and shroud portions. The inner shell sections are pinned to an outer containment shell formed of sections to preclude circumferential movement of the inner shell relative to the outer shell and enable thermal expansion and contraction of the inner shell relative to the outer shell. Positive bucket tip clearance control is afforded by passing a thermal medium about the inner shell in heat transfer relation with the shrouds about the first and second stage bucket tips, the thermal medium being provided from a source of heating/cooling fluid independent of the turbine. Access is provided to the rotor and turbine buckets by removing the outer and inner shell sections.

Capacitance-type blade-tip clearance measurement system using a dual amplifier with ramp/dc inputs and integration

NASA Technical Reports Server (NTRS)

Sarma, Garimella R.; Barranger, John P.

1992-01-01

The analysis and prototype results of a dual-amplifier circuit for measuring blade-tip clearance in turbine engines are presented. The capacitance between the blade tip and mounted capacitance electrode within a guard ring of a probe forms one of the feedback elements of an operational amplifier (op amp). The differential equation governing the circuit taking into consideration the nonideal features of the op amp was formulated and solved for two types of inputs (ramp and dc) that are of interest for the application. Under certain time-dependent constraints, it is shown that (1) with a ramp input the circuit has an output voltage proportional to the static tip clearance capacitance, and (2) with a dc input, the output is proportional to the derivative of the clearance capacitance, and subsequent integration recovers the dynamic capacitance. The technique accommodates long cable lengths and environmentally induced changes in cable and probe parameters. System implementation for both static and dynamic measurements having the same high sensitivity is also presented.

Capacitance-type blade-tip clearance measurement system using a dual amplifier with ramp/dc inputs and integration

NASA Astrophysics Data System (ADS)

Sarma, Garimella R.; Barranger, John P.

1992-10-01

The analysis and prototype results of a dual-amplifier circuit for measuring blade-tip clearance in turbine engines are presented. The capacitance between the blade tip and mounted capacitance electrode within a guard ring of a probe forms one of the feedback elements of an operational amplifier (op amp). The differential equation governing the circuit taking into consideration the nonideal features of the op amp was formulated and solved for two types of inputs (ramp and dc) that are of interest for the application. Under certain time-dependent constraints, it is shown that (1) with a ramp input the circuit has an output voltage proportional to the static tip clearance capacitance, and (2) with a dc input, the output is proportional to the derivative of the clearance capacitance, and subsequent integration recovers the dynamic capacitance. The technique accommodates long cable lengths and environmentally induced changes in cable and probe parameters. System implementation for both static and dynamic measurements having the same high sensitivity is also presented.

Investigation of the tip clearance flow inside and at the exit of a compressor rotor passage

NASA Technical Reports Server (NTRS)

Pandya, A.; Lakshminarayana, B.

1982-01-01

The nature of the tip clearance flow in a moderately loaded compressor rotor is studied. The measurements were taken inside the clearance between the annulus-wall casing and the rotor blade tip. These measurements were obtained using a stationary two-sensor hot-wire probe in combination with an ensemble averaging technique. The flowfield was surveyed at various radial locations and at ten axial locations, four of which were inside the blade passage in the clearance region and the remaining six outside the passage. Variations of the mean flow properties in the tangential and the radial directions at various axial locations were derived from the data. Variation of the leakage velocity at different axial stations and the annulus-wall boundary layer profiles from passage-averaged mean velocities were also estimated.

Influence of blade tip rounding on tip leakage vortex cavitation of axial flow pump

NASA Astrophysics Data System (ADS)

Wu, S. Q.; Shi, W. D.; Zhang, D. S.; Yao, J.; Cheng, C.

2013-12-01

Tip leakage flow in axial flow pumps is mainly caused by the tip clearance, which is the main cause of tip leakage vortex cavitation and blade tip cavitation erosion. In order to improve tip clearance flow and reduce TLV cavitation, four schemes were adopted to the round blade tip. These are: no tip rounding, one time tip clearance tip rounding, two times tip clearance tip rounding, four times tip clearance tip rounding. Using SST k-ω turbulence model and Zwart cavitation model in CFX software, this simulation obtained four kinds of inner flow field results. The numerical results indicated that with the increase of r*, NPSHc gradually increased and the cavitation performance reduced. However, corner vortex was eliminated so that cavitation in gap was restrained. But TLV vorticity increased and cavitation's range here had a little expansion. Combined with the research of this paper and the different analyses of four schemes, we recommend adopting the two times of the tip clearance rounding.

Evaluation of a Microwave Blade Tip Clearance Sensor for Propulsion Health Monitoring

NASA Technical Reports Server (NTRS)

Woike, Mark R.

2013-01-01

The NASA Glenn Research Center has investigated a microwave blade tip clearance system for the structural health monitoring of gas turbine engines. This presentation describes the sensors and the experiments that have been conducted to evaluate their performance along with future plans for their use on an engine ground test.

Analysis of middle bearing failure in rotor jet engine using tip-timing and tip-clearance techniques

NASA Astrophysics Data System (ADS)

Rzadkowski, R.; Rokicki, E.; Piechowski, L.; Szczepanik, R.

2016-08-01

The reported problem is the failure of the middle bearing in an aircraft rotor engine. Tip-timing and tip-clearance and variance analyses are carried out on a compressor rotor blade in the seventh stage above the middle bearing. The experimental analyses concern both an aircraft engine with a middle bearing in good working order and an engine with a damaged middle bearing. A numerical analysis of seventh stage blade free vibration is conducted to explain the experimental results. This appears to be an effective method of predicting middle bearing failure. The results show that variance first increases in the initial stages of bearing failure, but then starts to decrease and stabilize, and then again decrease shortly before complete bearing failure.

Numerical Analysis of the Acoustic Field of Tip-Clearance Flow

NASA Astrophysics Data System (ADS)

Alavi Moghadam, S. M.; M. Meinke Team; W. Schröder Team

2015-11-01

Numerical simulations of the acoustic field generated by a shrouded axial fan are studied by a hybrid fluid-dynamics-acoustics method. In a first step, large-eddy simulations are performed to investigate the dynamics of tip clearance flow for various tip gap sizes and to determine the acoustic sources. The simulations are performed for a single blade out of five blades with periodic boundary conditions in the circumferential direction on a multi-block structured mesh with 1.4 ×108 grid points. The turbulent flow is simulated at a Reynolds number of 9.36 ×105 at undisturbed inflow condition and the results are compared with experimental data. The diameter and strength of the tip vortex increase with the tip gap size, while simultaneously the efficiency of the fan decreases. In a second step, the acoustic field on the near field is determined by solving the acoustic perturbation equations (APE) on a mesh for a single blade consisting of approx. 9.8 ×108 grid points. The overall agreement of the pressure spectrum and its directivity with measurements confirm the correct identification of the sound sources and accurate prediction of the acoustic duct propagation. The results show that the longer the tip gap size the higher the broadband noise level. Senior Scientist, Institute of Aerodynamics, RWTH Aachen University.

Gas turbine engine active clearance control

NASA Technical Reports Server (NTRS)

Deveau, Paul J. (Inventor); Greenberg, Paul B. (Inventor); Paolillo, Roger E. (Inventor)

1985-01-01

Method for controlling the clearance between rotating and stationary components of a gas turbine engine are disclosed. Techniques for achieving close correspondence between the radial position of rotor blade tips and the circumscribing outer air seals are disclosed. In one embodiment turbine case temperature modifying air is provided in flow rate, pressure and temperature varied as a function of engine operating condition. The modifying air is scheduled from a modulating and mixing valve supplied with dual source compressor air. One source supplies relatively low pressure, low temperature air and the other source supplies relatively high pressure, high temperature air. After the air has been used for the active clearance control (cooling the high pressure turbine case) it is then used for cooling the structure that supports the outer air seal and other high pressure turbine component parts.

Seal Investigations of an Active Clearance Control System Concept

NASA Technical Reports Server (NTRS)

Steinetz, Bruce M.; Taylor, Shawn; Oswald, Jay; DeCastro, Jonathan A.

2006-01-01

In an effort to improve upon current thermal active clearance control methods, a first generation, fast-acting mechanically actuated, active clearance control system has been designed and installed into a non-rotating test rig. In order to harvest the benefit of tighter blade tip clearances, low-leakage seals are required for the actuated carrier segments of the seal shroud to prevent excessive leakage of compressor discharge (P3) cooling air. The test rig was designed and fabricated to facilitate the evaluation of these types of seals, identify seal leakage sources, and test other active clearance control system concepts. The objective of this paper is to present both experimental and analytical investigations into the nature of the face-seal to seal-carrier interface. Finite element analyses were used to examine face seal contact pressures and edge-loading under multiple loading conditions, varied E-seal positions and two new face seal heights. The analyses indicated that moving the E-seal inward radially and reducing face seal height would lead to more uniform contact conditions between the face seal and the carriers. Lab testing confirmed that moving the balance diameter inward radially caused a decrease in overall system leakage.

Discrete-Layer Piezoelectric Plate and Shell Models for Active Tip-Clearance Control

NASA Technical Reports Server (NTRS)

Heyliger, P. R.; Ramirez, G.; Pei, K. C.

1994-01-01

The objectives of this work were to develop computational tools for the analysis of active-sensory composite structures with added or embedded piezoelectric layers. The targeted application for this class of smart composite laminates and the analytical development is the accomplishment of active tip-clearance control in turbomachinery components. Two distinct theories and analytical models were developed and explored under this contract: (1) a discrete-layer plate theory and corresponding computational models, and (2) a three dimensional general discrete-layer element generated in curvilinear coordinates for modeling laminated composite piezoelectric shells. Both models were developed from the complete electromechanical constitutive relations of piezoelectric materials, and incorporate both displacements and potentials as state variables. This report describes the development and results of these models. The discrete-layer theories imply that the displacement field and electrostatic potential through-the-thickness of the laminate are described over an individual layer rather than as a smeared function over the thickness of the entire plate or shell thickness. This is especially crucial for composites with embedded piezoelectric layers, as the actuating and sensing elements within these layers are poorly represented by effective or smeared properties. Linear Lagrange interpolation polynomials were used to describe the through-thickness laminate behavior. Both analytic and finite element approximations were used in the plane or surface of the structure. In this context, theoretical developments are presented for the discrete-layer plate theory, the discrete-layer shell theory, and the formulation of an exact solution for simply-supported piezoelectric plates. Finally, evaluations and results from a number of separate examples are presented for the static and dynamic analysis of the plate geometry. Comparisons between the different approaches are provided when

Navier-Stokes analysis of an oxidizer turbine blade with tip clearance with and without a mini-shroud

NASA Technical Reports Server (NTRS)

Chan, Tony; Dejong, Frederik J.

1993-01-01

The Gas Generator Oxidizer Turbine (GGOT) Blade is being analyzed by various investigators under the NASA MSFC-sponsored Turbine Stage Technology Team design effort. The present work concentrates on the tip clearance region flow and associated losses; however, flow details for the passage region are also obtained in the simulations. The present calculations simulate the rotor blade row in a rotating reference frame with the appropriate coriolis and centrifugal acceleration term included in the momentum equations. The upstream computational boundary is located about one axial chord from the blade leading edge. The boundary conditions at this location have been determined by Pratt & Whitney using an Euler analysis without the vanes to obtain approximately the same flow profiles at the rotor as were obtained with the Euler stage analysis including the vanes. Inflow boundary layer profiles are then constructed assuming the skin friction coefficient at both the hub and the casing. The downstream computational boundary is located about one axial chord from the blade trailing edge, and the circumferentially averaged static pressure at this location was also obtained from the P&W Euler analysis. Results obtained for the 3-D baseline GGOT geometry at the full scale design Reynolds number show a region of high loss in the region near the casing. Particle traces in the near tip region show vortical flow behavior of the fluid which passes through the clearance region and exits at the downstream edge of the gap. In an effort to reduce clearance flow losses, the mini-shroud concept was proposed by the Pratt & Whitney design team. Calculations were performed on the GGO geometry with the mini-shroud. Results of these calculations indicate that the mini-shroud does not significantly affect the flow in the passage region, and although the tip clearance flow is different, the mini-shroud does not seem to prevent the above-mentioned vortical flow behavior. Since both flow distortion

The influences of tip clearance on the performance of nozzle blades of radial turbines - Experiment and performance prediction at three nozzle angles

NASA Astrophysics Data System (ADS)

Hyun, Yong-Ik; Yamaguchi, Michiteru; Hayami, Hiroshi; Senoo, Yasutoshi

1988-05-01

In order to study the influence of tip clearance on the turning angle and pressure loss of turbine nozzles, experimental results were obtained for nozzle angles at which the throat area was 0.8 and 1.4 times the rated condition. Contour maps of the total pressure loss and of the spanwise distributions of the mean exit-flow angle have been obtained. Although the two-layer flow model of Senoo et al., (1987) is shown to accurately predict the effects of tip clearance, it underestimates the clearance effect for a lightly loaded condition.

Microwave Sensor for Blade Tip Clearance and Structural Health Measurements

NASA Technical Reports Server (NTRS)

Woike, Mark R.; Bencic, Timothy J.

2008-01-01

The use of microwave based sensors for the health monitoring of rotating machinery is being explored at the NASA Glenn Research Center. The microwave sensor works on the principle of sending a continuous signal towards a rotating component and measuring the reflected signal. The phase shift of the reflected signal is proportional to the distance between the sensor and the component that is being measured. This type of sensor is beneficial in that it has the ability to operate at extremely high temperatures and is unaffected by contaminants that may be present in the rotating machinery. It is intended to use these probes in the hot sections of turbine engines for closed loop turbine clearance control and structural health measurements. Background on the sensors, an overview of their calibration and preliminary results from using them to make blade tip clearance and health measurements on a large axial vane fan will be presented.

Recent advances in capacitance type of blade tip clearance measurements

NASA Technical Reports Server (NTRS)

Barranger, John P.

1988-01-01

Two recent electronic advances at NASA-Lewis that meet the blade tip clearance needs of a wide class of fans, compressors, and turbines are described. The first is a frequency modulated (FM) oscillator that requires only a single low cost ultrahigh frequency operational amplifier. Its carrier frequency is 42.8 MHz when used with a 61 cm long hermetically sealed coaxial cable. The oscillator can be calibrated in the static mode and has a negative peak frequency deviation of 400 kHz for a typical rotor blade. High temperature performance tests of the probe and 13 cm of the adjacent cable show good accuracy up to 600 C, the maximum which produces a clearance error of + or - 10 microns at a clearance of 500 microns. In the second advance, a guarded probe configuration allows a longer cable capacitance. The capacitance of the probe is part of a small time constant feedback in a high speed operational amplifier. The solution of the governing differential equation is applied to a ramp type of input. The results show an amplifier output that contains a term which is proportional to the derivative of the feedback capacitance. The capacitance is obtained by subtracting a balancing reference channel followed by an integration stage.

Navier-Stokes analysis of an oxidizer turbine blade with tip clearance

NASA Technical Reports Server (NTRS)

Gibeling, Howard J.; Sabnis, Jayant S.

1992-01-01

The Gas Generator Oxidizer Turbine (GGOT) Blade is being analyzed by various investigators under the NASA MSFC sponsored Turbine Stage Technology Team design effort. The present work concentrates on the tip clearance region flow and associated losses; however, flow details for the passage region are also obtained in the simulations. The present calculations simulate the rotor blade row in a rotating reference frame with the appropriate coriolis and centrifugal acceleration terms included in the momentum equation. The upstream computational boundary is located about one axial chord from the blade leading edge. The boundary conditions at this location were determined by using a Euler analysis without the vanes to obtain approximately the same flow profiles at the rotor as were obtained with the Euler stage analysis including the vanes. Inflow boundary layer profiles are then constructed assuming the skin friction coefficient at both the hub and the casing. The downstream computational boundary is located about one axial chord from the blade trailing edge, and the circumferentially averaged static pressure at this location was also obtained from the Euler analysis. Results were obtained for the 3-D baseline GGOT geometry at the full scale design Reynolds number. Details of the clearance region flow behavior and blade pressure distributions were computed. The spanwise variation in blade loading distributions are shown, and circumferentially averaged spanwise distributions of total pressure, total temperature, Mach number, and flow angle are shown at several axial stations. The spanwise variation of relative total pressure loss shows a region of high loss in the region near the casing. Particle traces in the near tip region show vortical behavior of the fluid which passes through the clearance region and exits at the downstream edge of the gap.

Tip-leakage cavitation in the clearance of a 2D hydrofoil with fillets: high-speed visualization and PIV/PTV measurements

NASA Astrophysics Data System (ADS)

Zapryagaev, Ivan I.; Timoshevskiy, Mikhail V.; Pervunin, Konstantin S.

2017-09-01

Tip-clearance cavitation is one of the most aggressive forms of cavitation as it can cause surface erosion of hydraulic machinery elements and, as a result, their fatigue damage and disturb designed operating conditions. At present, the literature lacks for detailed experimental data on the inception and development of this type of cavitation at various flow conditions. In the paper, a tip-leakage cavitation occurring in the clearance between an end face of a 2D hydrofoil (a scaled-down model of guide vanes (GV) of a Francis turbine) and a transparent wall of the test section was studied. The experiments were carried out for different cavitating regimes on the cavitation number and two attack angles of 3° and 9°, with the gap size (tip clearance width) varied in the range from 0.4 to 0.8 mm. In order to determine the cavitation inception conditions and investigate the dynamics of the tip-leakage cavitation, a high-speed visualization was applied. A modified PIV/PTV technique with a diverging laser beam instead of a laser light sheet was used to measure the mean velocity distributions within the gap. It was shown that the cavitation pattern on the suction side of the GV model impacts the dynamics of the leakage flow in the gap but does not affect the sheet cavity formed close to the foil leading edge in the clearance as well as its size and dynamics. When the gap size is increased, the tip-leakage cavitation initiates at higher cavitation numbers or, in other words, conditions for the cavitation occurrence become more favorable.

Research turbine for high-temperature core engine application. 2: Effect of rotor tip clearance on overall performance

NASA Technical Reports Server (NTRS)

Szanca, E. M.; Behning, F. P.; Schum, H. J.

1974-01-01

A 25.4-cm (10-in) tip diameter turbine was tested to determine the effect of rotor radial tip clearance on turbine overall performance. The test turbine was a half-scale model of a 50.8-cm-(20-in.-) diameter research turbine designed for high-temperature core engine application. The test turbine was fabricated with solid vanes and blades with no provision for cooling air and tested at much reduced inlet conditions. The tests were run at design speed over a range of pressure ratios for three different rotor clearances ranging from 2.3 to 6.7 percent of the annular blade passage height. The results obtained are compared to the results obtained with three other turbines of varying amounts of reaction.

Local measurement and numerical modeling of mass/heat transfer from a turbine blade in a linear cascade with tip clearance

NASA Astrophysics Data System (ADS)

Jin, Peitong

2000-11-01

Local mass/heat transfer measurements from the turbine blade near-tip and the tip surfaces are performed using the naphthalene sublimation technique. The experiments are conducted in a linear cascade consisting of five high-pressure blades with a central test-blade configuration. The incoming flow conditions are close to those of the gas turbine engine environment (boundary layer displacement thickness is about 0.01 of chord) with an exit Reynolds number of 6.2 x 105. The effects of tip clearance level (0.86%--6.90% of chord), mainstream Reynolds number and turbulence intensity (0.2 and 12.0%) are investigated. Two methods of flow visualization---oil and lampblack, laser light sheet smoke wire---as well as static pressure measurement on the blade surface are used to study the tip leakage flow and vortex in the cascade. In addition, numerical modeling of the flow and heat transfer processes in the linear cascade with different tip clearances is conducted using commercial software incorporating advanced turbulence models. The present study confirms many important results on the tip leakage flow and vortex from the literature, contributes to the current understanding in the effects of tip leakage flow and vortex on local heat transfer from the blade near-tip and the tip surfaces, and provides detailed local and average heat/mass transfer data applicable to turbine blade tip cooling design.

Techniques for blade tip clearance measurements with capacitive probes

NASA Astrophysics Data System (ADS)

Steiner, Alexander

2000-07-01

This article presents a proven but advantageous concept for blade tip clearance evaluation in turbomachinery. The system is based on heavy duty probes and a high frequency (HF) and amplifying electronic unit followed by a signal processing unit. Measurements are taken under high temperature and other severe conditions such as ionization. Every single blade can be observed. The signals are digitally filtered and linearized in real time. The electronic set-up is highly integrated. Miniaturized versions of the electronic units exist. The small and robust units can be used in turbo engines in flight. With several probes at different angles in one radial plane further information is available. Shaft eccentricity or blade oscillations can be calculated.

Reynolds-averaged Navier-Stokes computation on tip clearance flow in a compressor cascade using an unstructured grid

NASA Astrophysics Data System (ADS)

Shin, Sangmook

2001-07-01

A three-dimensional unstructured incompressible RANS code has been developed using artificial compressibility and Spalart-Allmaras eddy viscosity model. A node-based finite volume method is used in which all flow variables are defined at the vertices of tetrahedrons in an unstructured grid. The inviscid fluxes are computed by using the Roe's flux difference splitting method, and higher order accuracy is attained by data reconstruction based on Taylor series expansion. Gauss theorem is used to formulate necessary gradients. For time integration, an implicit scheme based on linearized Euler backward method is used. A tetrahedral unstructured grid generation code has been also developed and applied to the tip clearance flow in a highly staggered cascade. Surface grids are first generated in the flow passage and blade tip by using several triangulation methods including Delaunay triangulation, advancing front method and advancing layer method. Then the whole computational domain including tip gap region is filled with prisms using the surface grids. The code has been validated by comparisons with available computational and experimental results for several test cases: inviscid flow around NACA section, laminar and turbulent flow over a flat plate, turbulent flow through double-circular arc cascade and laminar flow through a square duct with 90° bend. Finally the code is applied to a linear cascade that has GE rotor B section with tip clearance and a high stagger angle of 56.9°. The overall structure of the tip clearance flow is well predicted. Loss of loading due to tip leakage flow and reloading due to tip leakage vortex are presented. On the end wall, separation line of the tip leakage vortex and reattachment line of passage vortex are identified. Prediction of such an interaction presents a challenge to RANS computations. The effects of blade span on the flow structure have been also investigated. Two cascades with blades of aspect ratios of 0.5 and 1.0 are

A Microwave Blade Tip Clearance Sensor for Propulsion Health Monitoring

NASA Technical Reports Server (NTRS)

Woike, Mark R.; Abdul-Aziz, Ali; Bencic, Timothy J.

2010-01-01

Microwave sensor technology is being investigated by the NASA Glenn Research Center as a means of making non-contact structural health measurements in the hot sections of gas turbine engines. This type of sensor technology is beneficial in that it is accurate, it has the ability to operate at extremely high temperatures, and is unaffected by contaminants that are present in turbine engines. It is specifically being targeted for use in the High Pressure Turbine (HPT) and High Pressure Compressor (HPC) sections to monitor the structural health of the rotating components. It is intended to use blade tip clearance to monitor blade growth and wear and blade tip timing to monitor blade vibration and deflection. The use of microwave sensors for this application is an emerging concept. Techniques on their use and calibration needed to be developed. As a means of better understanding the issues associated with the microwave sensors, a series of experiments have been conducted to evaluate their performance for aero engine applications. This paper presents the results of these experiments.

Study of tip clearance flow in a turbomachinery cascade using large eddy simulation

NASA Astrophysics Data System (ADS)

You, Donghyun

In liquid handling systems like pumps and ducted propulsors, low pressure events in the vicinity and downstream of the rotor tip gap can induce tip-leakage cavitation which leads to noise, vibration, performance loss, and erosions of blade and casing wall. In order to analyze the dynamics of the tip-clearance flow and determine the underlying mechanism for the low pressure events, a newly developed large-eddy simulation (LES) solver which combines an immersed-boundary method with a generalized curvilinear structured grid has been employed. An analysis of the LES results has been performed to understand the mean flow field, turbulence characteristics, vortex dynamics, and pressure fluctuations in the turbomachinery cascade with tip gap. In the cascade passage, the tip-leakage jet, which is generated by the pressure difference between the pressure and suction sides of the blade tip, is found to produce highly enhanced vorticity magnitude and significant levels of turbulent kinetic energy. Based on the understanding of the flow field, a guideline for reducing viscous loss in the cascade is provided. Analyses of the energy spectra and space-time correlations of the velocity fluctuations suggest that the tip-leakage vortex is subject to pitchwise wandering motion. The largest pressure drop and most intense pressure fluctuations due to the formation of the tip-leakage vortex are found at the location where the strongest portion of the tip-leakage vortex is found. Present study suggests that the tip-leakage vortex needs to be controlled in its origin to reduce cavitation in the present configuration. The effects of tip-gap size on the end-wall vortical structures and on the velocity and pressure fields have been investigated. The present analysis indicates that the mechanism for the generation of the vorticity and turbulent kinetic energy is mostly unchanged by the tip-gap size variation. However, larger tip-gap sizes are found to be more inductive to tip

Task II: Three-dimensional Rotating Stall Inception and Effects of Rotating Tip Clearance Asymmetry in Axial Compressors

NASA Technical Reports Server (NTRS)

Suder, Kenneth (Technical Monitor); Tan, Choon-Sooi

2003-01-01

by the integral around the annulus of the pressure rise characteristic slope, weighted by the amplitude of the mode shape. For the case of steady circumferential variations, this criterion reduced to the integrated mean slope (IMS) condition associated with steady inlet distortions. The rotating tip clearance asymmetry model was also used to demonstrate the feasibility of actively controlling the shaft position to suppress rotating stall. In axisymmetric mean flow, this method only stabilized the first harmonic mode, increasing the operating range until surge or higher harmonic modes became unstable.

JT9D-70/59 Improved High Pressure Turbine Active Clearance Control System. [for specific fuel consumption improvement

NASA Technical Reports Server (NTRS)

Gaffin, W. O.

1979-01-01

The JT9D-70/59 high pressure turbine active clearance control system was modified to provide reduction of blade tip clearance when the system is activated during cruise operation. The modification increased the flow capacity and air impingement effectiveness of the cooling air manifold to augment turbine case shrinkage capability, and increased responsiveness of the airseal clearance to case shrinkage. The simulated altitude engine testing indicated a significant improvement in specific fuel consumption with the modified system. A 1000 cycle engine endurance test showed no unusual wear or performance deterioration effects on the engine or the clearance control system. Rig tests indicated that the air impingement and seal support configurations used in the engine tests are near optimum.

Distributed collaborative probabilistic design for turbine blade-tip radial running clearance using support vector machine of regression

NASA Astrophysics Data System (ADS)

Fei, Cheng-Wei; Bai, Guang-Chen

2014-12-01

To improve the computational precision and efficiency of probabilistic design for mechanical dynamic assembly like the blade-tip radial running clearance (BTRRC) of gas turbine, a distribution collaborative probabilistic design method-based support vector machine of regression (SR)(called as DCSRM) is proposed by integrating distribution collaborative response surface method and support vector machine regression model. The mathematical model of DCSRM is established and the probabilistic design idea of DCSRM is introduced. The dynamic assembly probabilistic design of aeroengine high-pressure turbine (HPT) BTRRC is accomplished to verify the proposed DCSRM. The analysis results reveal that the optimal static blade-tip clearance of HPT is gained for designing BTRRC, and improving the performance and reliability of aeroengine. The comparison of methods shows that the DCSRM has high computational accuracy and high computational efficiency in BTRRC probabilistic analysis. The present research offers an effective way for the reliability design of mechanical dynamic assembly and enriches mechanical reliability theory and method.

In-place recalibration technique applied to a capacitance-type system for measuring rotor blade tip clearance

NASA Technical Reports Server (NTRS)

Barranger, J. P.

1978-01-01

The rotor blade tip clearance measurement system consists of a capacitance sensing probe with self contained tuning elements, a connecting coaxial cable, and remotely located electronics. Tests show that the accuracy of the system suffers from a strong dependence on probe tip temperature and humidity. A novel inplace recalibration technique was presented which partly overcomes this problem through a simple modification of the electronics that permits a scale factor correction. This technique, when applied to a commercial system significantly reduced errors under varying conditions of humidity and temperature. Equations were also found that characterize the important cable and probe design quantities.

Study of the capacitance technique for measuring high-temperature blade tip clearance on ceramic rotors

NASA Technical Reports Server (NTRS)

Barranger, John P.

1993-01-01

Higher operating temperatures required for increased engine efficiency can be achieved by using ceramic materials for engine components. Ceramic turbine rotors are subject to the same limitations with regard to gas path efficiency as their superalloy predecessors. In this study, a modified frequency-modulation system is proposed for the measurement of blade tip clearance on ceramic rotors. It is expected to operate up to 1370 C (2500 F), the working temperature of present engines with ceramic turbine rotors. The design of the system addresses two special problems associated with nonmetallic blades: the capacitance is less than that of a metal blade and the effects of temperature may introduce uncertainty with regard to the blade tip material composition. To increase capacitance and stabilize the measurement, a small portion of the rotor is modified by the application of 5-micron-thick platinum films. The platinum surfaces on the probe electrodes and rotor that are exposed to the high-velocity gas stream are coated with an additional 10-micron-thick protective ceramic topcoat. A finite-element method is applied to calculate the capacitance as a function of clearance.

Study of blade clearance effects on centrifugal pumps

NASA Technical Reports Server (NTRS)

Hoshide, R. K.; Nielson, C. E.

1972-01-01

A program of analysis, design, fabrication, and testing has been conducted to develop and experimentally verify analytical models to predict the effects of impeller blade clearance on centrifugal pumps. The effect of tip clearance on pump efficiency, and the relationship between the head coefficient and torque loss with tip clearance was established. Analysis were performed to determine the cost variation in design, manufacture, and test that would occur between unshrouded and shrouded impellers. An impeller, representative of typical rocket engine impellers, was modified by removing its front shroud to permit variation of its blade clearances. It was tested in water with special instrumentation to provide measurements of blade surface pressures during operation. Pump performance data were obtained from tests at various impeller tip clearances. Blade pressure data were obtained at the nominal tip clearance. Comparisons of predicted and measured data are given.

An Experimental Investigation of the Flow Physics Associated With End Wall Losses and Large Rotor Tip Clearances as Found in the Rear Stages of a High Pressure Compressor

NASA Technical Reports Server (NTRS)

Berdanier, Reid A.; Key, Nicole L.

2015-01-01

The focus of this work was to characterize the fundamental flow physics and the overall performance effects due to increased rotor tip clearance heights in axial compressors. Data have been collected in the three-stage axial research compressor at Purdue University with a specific focus on analyzing the multistage effects resulting from the tip leakage flow. Three separate rotor tip clearance heights were studied with nominal tip clearance heights of 1.5%, 3.0%, and 4.0% based on a constant annulus height. Overall compressor performance was investigated at four corrected speedlines (100%, 90%, 80%, and 68%) for each of the three tip clearance configurations using total pressure and total temperature rakes distributed throughout the compressor. The results have confirmed results from previous authors showing a decrease of total pressure rise, isentropic efficiency, and stall margin which is approximately linear with increasing tip clearance height. The stall inception mechanisms have also been evaluated at the same corrected speeds for each of the tip clearance configurations. Detailed flow field measurements have been collected at two loading conditions, nominal loading (NL) and high loading (HL), on the 100% corrected speedline for the smallest and largest tip clearance heights (1.5% and 4.0%). Steady detailed radial traverses of total pressure at the exit of each stator row have been supported by flow visualization techniques to identify regions of flow recirculation and separation. Furthermore, detailed radial traverses of time-resolved total pressures at the exit of each rotor row have been measured with a fast-response pressure probe. These data have helped to quantify the size of the leakage flow at the exit of each rotor. Thermal anemometry has also been implemented to evaluate the time-resolved three-dimensional components of velocity throughout the compressor and calculate blockage due to the rotor tip leakage flow throughout the compressor. These

Blade tip clearance measurement of the turbine engines based on a multi-mode fiber coupled laser ranging system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guo, Haotian; Duan, Fajie; Wu, Guoxiu

2014-11-15

The blade tip clearance is a parameter of great importance to guarantee the efficiency and safety of the turbine engines. In this article, a laser ranging system designed for blade tip clearance measurement is presented. Multi-mode fiber is utilized for optical transmission to guarantee that enough optical power is received by the sensor probe. The model of the tiny sensor probe is presented. The error brought by the optical path difference of different modes of the fiber is estimated and the length of the fiber is limited to reduce this error. The measurement range in which the optical power receivedmore » by the probe remains essentially unchanged is analyzed. Calibration experiments and dynamic experiments are conducted. The results of the calibration experiments indicate that the resolution of the system is about 0.02 mm and the range of the system is about 9 mm.« less

Comparison of Various Supersonic Turbine Tip Designs to Minimize Aerodynamic Loss and Tip Heating

NASA Technical Reports Server (NTRS)

Shyam, Vikram; Ameri, Ali

2012-01-01

The rotor tips of axial turbines experience high heat flux and are the cause of aerodynamic losses due to tip clearance flows, and in the case of supersonic tips, shocks. As stage loadings increase, the flow in the tip gap approaches and exceeds sonic conditions. This introduces effects such as shock-boundary layer interactions and choked flow that are not observed for subsonic tip flows that have been studied extensively in literature. This work simulates the tip clearance flow for a flat tip, a diverging tip gap and several contoured tips to assess the possibility of minimizing tip heat flux while maintaining a constant massflow from the pressure side to the suction side of the rotor, through the tip clearance. The Computational Fluid Dynamics (CFD) code GlennHT was used for the simulations. Due to the strong favorable pressure gradients the simulations assumed laminar conditions in the tip gap. The nominal tip gap width to height ratio for this study is 6.0. The Reynolds number of the flow is 2.4 x 10(exp 5) based on nominal tip width and exit velocity. A wavy wall design was found to reduce heat flux by 5 percent but suffered from an additional 6 percent in aerodynamic loss coefficient. Conventional tip recesses are found to perform far worse than a flat tip due to severe shock heating. Overall, the baseline flat tip was the second best performer. A diverging converging tip gap with a hole was found to be the best choice. Average tip heat flux was reduced by 37 percent and aerodynamic losses were cut by over 6 percent.

Low-cost FM oscillator for capacitance type of blade tip clearance measurement system

NASA Technical Reports Server (NTRS)

Barranger, John P.

1987-01-01

The frequency-modulated (FM) oscillator described is part of a blade tip clearance measurement system that meets the needs of a wide class of fans, compressors, and turbines. As a result of advancements in the technology of ultra-high-frequency operational amplifiers, the FM oscillator requires only a single low-cost integrated circuit. Its carrier frequency is 42.8 MHz when it is used with an integrated probe and connecting cable assembly consisting of a 0.81 cm diameter engine-mounted capacitance probe and a 61 cm long hermetically sealed coaxial cable. A complete circuit analysis is given, including amplifier negative resistance characteristics. An error analysis of environmentally induced effects is also derived, and an error-correcting technique is proposed. The oscillator can be calibrated in the static mode and has a negative peak frequency deviation of 400 kHz for a rotor blade thickness of 1.2 mm. High-temperature performance tests of the probe and 13 cm of the adjacent cable show good accuracy up to 600 C, the maximum permissible seal temperature. The major source of error is the residual FM oscillator noise, which produces a clearance error of + or - 10 microns at a clearance of 0.5 mm. The oscillator electronics accommodates the high rotor speeds associated with small engines, the signals from which may have frequency components as high as 1 MHz.

Local Mass and Heat Transfer on a Turbine Blade Tip

DOE PAGES

Jin, P.; Goldstein, R. J.

2003-01-01

Locmore » al mass and heat transfer measurements on a simulated high-pressure turbine blade-tip surface are conducted in a linear cascade with a nonmoving tip endwall, using a naphthalene sublimation technique. The effects of tip clearance (0.86–6.90% of chord) are investigated at various exit Reynolds numbers (4–7 × 10 5 ) and turbulence intensities (0.2 and 12.0%). The mass transfer on the tip surface is significant along its pressure edge at the smallest tip clearance. At the two largest tip clearances, the separation bubble on the tip surface can cover the whole width of the tip on the second half of the tip surface. The average mass-transfer rate is highest at a tip clearance of 1.72% of chord. The average mass-transfer rate on the tip surface is four and six times as high as on the suction and the pressure surface, respectively. A high mainstream turbulence level of 12.0% reduces average mass-transfer rates on the tip surface, while the higher mainstream Reynolds number generates higher local and average mass-transfer rates on the tip surface.« less

Advanced turbine blade tip seal system

NASA Technical Reports Server (NTRS)

Zelahy, J. W.

1981-01-01

An advanced blade/shroud system designed to maintain close clearance between blade tips and turbine shrouds and at the same time, be resistant to environmental effects including high temperature oxidation, hot corrosion, and thermal cycling is described. Increased efficiency and increased blade life are attained by using the advanced blade tip seal system. Features of the system include improved clearance control when blade tips preferentially wear the shrouds and a superior single crystal superalloy tip. The tip design, joint location, characterization of the single crystal tip alloy, the abrasive tip treatment, and the component and engine test are among the factors addressed. Results of wear testing, quality control plans, and the total manufacturing cycle required to fully process the blades are also discussed.

Annulus wall boundary layer development in a compressor stage, including the effects of tip clearance

NASA Technical Reports Server (NTRS)

Lakshminarayana, B.; Murthy, K. N. S.; Pouagare, M.; Govindan, T. R.

1983-01-01

The end-wall boundary layer development in a compressor stage, including the inlet guide vane (IGV) passage and the rotor passage, was measured. The measurement upstream of the rotor and inside the IGV passage were carried out with a five-hole probe. The data (blade-to-blade) inside the IGV passage were carried out with a five-hole probe. The data (blade-to-blade) inside the rotor passage were measured using a three-sensor rotating hot-wire below the tip clearance region and "V' configuration probe inside the clearance region. The rotor exit measurements (blade-to-blade) were acquired with a laser Doppler velocimeter. The velocity profiles and the integral properties are presented and interpreted. The boundary layer is comparatively well behaved up to the leading edge of the rotor, beyond which complex interactions result in very unconventional profiles. The momentum thicknesses decrease in the leakage flow region of the rotor. The momentum thicknesses and the limiting streamline angles predicted from a momentum integral technique agree well with the data up to the leading edge of the rotor.

Optical Tip Clearance Measurements as a Tool for Rotating Disk Characterization

PubMed Central

García, Iker; Zubia, Joseba; Beloki, Josu; Arrue, Jon; Durana, Gaizka; Aldabaldetreku, Gotzon

2017-01-01

An experimental investigation on the vibrational behavior of a rotating disk by means of three optical fiber sensors is presented. The disk, which is a scale model of the real disk of an aircraft engine, was assembled in a wind tunnel in order to simulate real operation conditions. The pressure difference between the upstream and downstream sides of the disk causes an airflow that might force the disk to vibrate. To characterize this vibration, a set of parameters was determined by measuring the tip clearance of the disk: the amplitude, the frequency and the number of nodal diameters in the disk. All this information allowed the design of an upgraded prototype of the disk, whose performance was also characterized by the same method. An optical system was employed for the measurements, in combination with a strain gauge mounted on the disk surface, which served to confirm the results obtained. The data of the strain gauge coincided closely with those provided by the optical fiber sensors, thus demonstrating the suitability of this innovative technique to evaluate the vibrational behavior of rotating disks. PMID:28098845

Numerical analysis of turbine blade tip treatments

NASA Technical Reports Server (NTRS)

Gopalaswamy, Nath S.; Whitaker, Kevin W.

1992-01-01

Three-dimensional solutions of the Navier-Stokes equations for a turbine blade with a turning angle of 180 degrees have been computed, including blade tip treatments involving cavities. The geometry approximates a preliminary design for the GGOT (Generic Gas Oxidizer Turbine). The data presented here will be compared with experimental data to be obtained from a linear cascade using original GGOT blades. Results have been computed for a blade with 1 percent clearance, based on chord, and three different cavity sizes. All tests were conducted at a Reynolds number of 4 x 10 exp 7. The grid contains 39,440 points with 10 spanwise planes in the tip clearance region of 5.008E-04 m. Streamline plots and velocity vectors together with velocity divergence plots reveal the general flow behavior in the clearance region. Blade tip temperature calculations suggest placement of a cavity close to the upstream side of the blade tip for reduction of overall blade tip temperature. The solutions do not account for the relative motion between the endwall and the turbine blade. The solutions obtained are generally consistent with previous work done in this area,

Rotor whirl forces induced by the tip clearance effect in axial flow compressors

NASA Astrophysics Data System (ADS)

Ehrich, F.

1993-10-01

It is now widely recognized that destabilizing forces, tending to generate forward rotor whirl, are generated in axial flow turbines as a result of the nonuniform torque induced by the nonuniform tip-clearance in a deflected rotor-the so called Thomas/Alford force (Thomas, 1958, and Alford, 1965). It is also recognized that there will be a similar effect in axial flow compressors, but qualitative considerations cannot definitively establish the magnitude or even the direction of the induced whirling forces-that is, if they will tend to forward or backward whirl. Applying a 'parallel compressor' model to simulate the operation of a compressor rotor deflected radially in its clearance, it is possible to derive a quantitative estimate of the proportionality factor which relates the Thomas/Alford force in axial flow compressors (i.e., the tangential force generated by a radial deflection of the rotor) to the torque level in the compressor. The analysis makes use of experimental data from the GE Aircraft Engines Low Speed Research Compressor facility comparing the performance of three different axial flow compressors, each with four stages (typical of a mid-block of an aircraft gas turbine compressor) at two different clearances (expressed as a percent of blade length) - CL/L = 1.4 percent and CL/L = 2.8 percent. It is found that the value of Beta is in the range of + 0.27 to - 0.71 in the vicinity of the stages' nominal operating line and + 0.08 to - 1.25 in the vicinity of the stages' operation at peak efficiency. The value of Beta reaches a level of between - 1.16 and - 3.36 as the compressor is operated near its stalled condition. The final result bears a very strong resemblance to the correlation obtained by improvising a normalization of the experimental data of Vance and Laudadio (1984) and a generic relationship to the analytic results of Colding-Jorgensen (1990).

Smart helicopter rotor with active blade tips

NASA Astrophysics Data System (ADS)

Bernhard, Andreas Paul Friedrich

2000-10-01

The smart active blade tip (SABT) rotor is an on-blade rotor vibration reduction system, incorporating active blade tips that can be independently pitched with respect to the main blade. The active blade tip rotor development included an experimental test program culminating in a Mach scale hover test, and a parallel development of a coupled, elastic actuator and rotor blade analysis for preliminary design studies and hover performance prediction. The experimental testing focussed on a small scale rotor on a bearingless Bell-412 hub. The fabricated Mach-scale active-tip rotor has a diameter of 1.524 m, a blade chord of 76.2 mm and incorporated a 10% span active tip. The nominal operating speed is 2000 rpm, giving a tip Mach number of 0.47. The blade tips are driven by a novel piezo-induced bending-torsion coupled actuator beam, located spanwise in the hollow mid-cell of the main rotor blade. In hover at 2000 rpm, at 2 deg collective, and for an actuation of 125 Vrms, the measured blade tip deflection at the first four rotor harmonics is between +/-1.7 and +/-2.8 deg, increasing to +/-5.3 deg at 5/rev with resonant amplification. The corresponding oscillatory amplitude of the rotor thrust coefficient is between 0.7 · 10-3 and 1.3 · 10-1 at the first four rotor harmonics, increasing to 2.1 · 10-3 at 5/rev. In general, the experimental blade tip frequency response and corresponding rotor thrust response are well captured by the analysis. The flexbeam root flap bending moment is predicted in trend, but is significantly over-estimated. The blade tips did not deflect as expected at high collective settings, because of the blade tip shaft locking up in the bearing. This is caused by the high flap bending moment on the blade tip shaft. Redesign of the blade tip shaft assembly and bearing support is identified as the primary design improvement for future research. The active blade tip rotor was also used as a testbed for the evaluation of an adaptive neural-network based

ADAPTIVE CLEARANCE CONTROL SYSTEMS FOR TURBINE ENGINES

NASA Technical Reports Server (NTRS)

Blackwell, Keith M.

2004-01-01

The Controls and Dynamics Technology Branch at NASA Glenn Research Center primarily deals in developing controls, dynamic models, and health management technologies for air and space propulsion systems. During the summer of 2004 I was granted the privilege of working alongside professionals who were developing an active clearance control system for commercial jet engines. Clearance, the gap between the turbine blade tip and the encompassing shroud, increases as a result of wear mechanisms and rubbing of the turbine blades on shroud. Increases in clearance cause larger specific fuel consumption (SFC) and loss of efficient air flow. This occurs because, as clearances increase, the engine must run hotter and bum more fuel to achieve the same thrust. In order to maintain efficiency, reduce fuel bum, and reduce exhaust gas temperature (EGT), the clearance must be accurately controlled to gap sizes no greater than a few hundredths of an inch. To address this problem, NASA Glenn researchers have developed a basic control system with actuators and sensors on each section of the shroud. Instead of having a large uniform metal casing, there would be sections of the shroud with individual sensors attached internally that would move slightly to reform and maintain clearance. The proposed method would ultimately save the airline industry millions of dollars.

Numerical analysis of the blade tip-timing signal of a fiber bundle sensor probe

NASA Astrophysics Data System (ADS)

Guo, Haotian; Duan, Fajie; Cheng, Zhonghai

2015-03-01

Blade tip-timing is the most effective method for online blade vibration measurement of large rotating machines like turbine engines. Fiber bundle sensors are utilized in tip-timing system to measure the arrival time of the blade. The model of the tip-timing signal of the fiber bundle sensor is established. Experiments are conducted and the results are in concordance with the model established. The rising speed of the tip-timing signal is analyzed. To minimize the tip-timing error, the effects of the clearance change between the sensor and the blade and the deflection of the tip surface are analyzed. Simulation results indicate that the variable gain amplifier, which amplifies the signals to a similar level, can eliminate the measurement error caused by the variation of the clearance between the sensor and blade. Increasing the clearance between the sensor and blade can reduce the measurement error introduced by deflection of the tip surface.

Tip clearance noise of axial flow fans operating at design and off-design condition

NASA Astrophysics Data System (ADS)

Fukano, T.; Jang, C.-M.

2004-08-01

The noise due to tip clearance (TC) flow in axial flow fans operating at a design and off-design conditions is analyzed by an experimental measurement using two hot-wire probes rotating with the fan blades. The unsteady nature of the spectra of the real-time velocities measured by two hot-wire sensors in a vortical flow region is investigated by using cross-correlation coefficient and retarded time of the two fluctuating velocities. The results show that the noise due to TC flow consists of a discrete frequency noise due to periodic velocity fluctuation and a broadband noise due to velocity fluctuation in the blade passage. The peak frequencies in a vortical flow are mainly observed below at four harmonic blade passing frequency. The discrete frequency component of velocity fluctuation at the off-design operating conditions is generated in vortical flow region as well as in reverse flow region. The peak frequency can be an important noise source when the fans are rotated with a high rotational speed. The authors propose a spiral pattern of velocity fluctuation in the vortical flow to describe the generation mechanism of the peak frequency in the vortical flow. In addition, noise increase due to TC flow at low flow rate condition is analyzed with relation to the distribution of velocity fluctuation due to the interference between the tip leakage vortex and the adjacent pressure surface of the blade.

Tip-Clearance Measurement in the First Stage of the Compressor of an Aircraft Engine.

PubMed

García, Iker; Przysowa, Radosław; Amorebieta, Josu; Zubia, Joseba

2016-11-11

In this article, we report the design of a reflective intensity-modulated optical fiber sensor for blade tip-clearance measurement, and the experimental results for the first stage of a compressor of an aircraft engine operating in real conditions. The tests were performed in a ground test cell, where the engine completed four cycles from idling state to takeoff and back to idling state. During these tests, the rotational speed of the compressor ranged between 7000 and 15,600 rpm. The main component of the sensor is a tetrafurcated bundle of optical fibers, with which the resulting precision of the experimental measurements was 12 µm for a measurement range from 2 to 4 mm. To get this precision the effect of temperature on the optoelectronic components of the sensor was compensated by calibrating the sensor in a climate chamber. A custom-designed MATLAB program was employed to simulate the behavior of the sensor prior to its manufacture.

Tip-Clearance Measurement in the First Stage of the Compressor of an Aircraft Engine

PubMed Central

García, Iker; Przysowa, Radosław; Amorebieta, Josu; Zubia, Joseba

2016-01-01

In this article, we report the design of a reflective intensity-modulated optical fiber sensor for blade tip-clearance measurement, and the experimental results for the first stage of a compressor of an aircraft engine operating in real conditions. The tests were performed in a ground test cell, where the engine completed four cycles from idling state to takeoff and back to idling state. During these tests, the rotational speed of the compressor ranged between 7000 and 15,600 rpm. The main component of the sensor is a tetrafurcated bundle of optical fibers, with which the resulting precision of the experimental measurements was 12 µm for a measurement range from 2 to 4 mm. To get this precision the effect of temperature on the optoelectronic components of the sensor was compensated by calibrating the sensor in a climate chamber. A custom-designed MATLAB program was employed to simulate the behavior of the sensor prior to its manufacture. PMID:27845709

28 CFR 524.74 - Activities clearance.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., AND TRANSFER CLASSIFICATION OF INMATES Central Inmate Monitoring (CIM) System § 524.74 Activities... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Activities clearance. 524.74 Section 524... authority on all transfers, temporary releases, community activities, and escorted trips. (b) Witness...

28 CFR 524.74 - Activities clearance.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., AND TRANSFER CLASSIFICATION OF INMATES Central Inmate Monitoring (CIM) System § 524.74 Activities... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Activities clearance. 524.74 Section 524... authority on all transfers, temporary releases, community activities, and escorted trips. (b) Witness...

28 CFR 524.74 - Activities clearance.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., AND TRANSFER CLASSIFICATION OF INMATES Central Inmate Monitoring (CIM) System § 524.74 Activities... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Activities clearance. 524.74 Section 524... authority on all transfers, temporary releases, community activities, and escorted trips. (b) Witness...

28 CFR 524.74 - Activities clearance.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., AND TRANSFER CLASSIFICATION OF INMATES Central Inmate Monitoring (CIM) System § 524.74 Activities... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Activities clearance. 524.74 Section 524... authority on all transfers, temporary releases, community activities, and escorted trips. (b) Witness...

An Experimental Characterization of Tip Leakage Flows and Corresponding Effects on Multistage Compressor Performance

NASA Astrophysics Data System (ADS)

Berdanier, Reid Adam

The effect of rotor tip clearances in turbomachinery applications has been a primary research interest for nearly 80 years. Over that time, studies have shown increased tip clearance in axial flow compressors typically has a detrimental effect on overall pressure rise capability, isentropic efficiency, and stall margin. With modern engine designs trending toward decreased core sizes to increase propulsive efficiency (by increasing bypass ratio) or additional compression stages to increase thermal efficiency by increasing the overall pressure ratio, blade heights in the rear stages of the high pressure compressor are expected to decrease. These rear stages typically feature smaller blade aspect ratios, for which endwall flows are more important, and the rotor tip clearance height represents a larger fraction of blade span. As a result, data sets collected with large relative rotor tip clearance heights are necessary to facilitate these future small core design goals. This research seeks to characterize rotor tip leakage flows for three tip clearance heights in the Purdue three-stage axial compressor facility (1.5%, 3.0%, and 4.0% as a percentage of overall annulus height). The multistage environment of this compressor provides the unique opportunity to examine tip leakage flow effects due to stage matching, stator-rotor interactions, and rotor-rotor interactions. The important tip leakage flow effects which develop as a result of these interactions are absent for previous studies which have been conducted using single-stage machines or isolated rotors. A series of compressor performance maps comprise points at four corrected speeds for each of the three rotor tip clearance heights. Steady total pressure and total temperature measurements highlight the effects of tip leakage flows on radial profiles and wake shapes throughout the compressor. These data also evaluate tip clearance effects on efficiency, stall margin, and peak pressure rise capability. An emphasis of

Materials for advanced turbine engines. Volume 1: Advanced blade tip seal system

NASA Technical Reports Server (NTRS)

Zelahy, J. W.; Fairbanks, N. P.

1982-01-01

Project 3, the subject of this technical report, was structured toward the successful engine demonstration of an improved-efficiency, long-life, tip-seal system for turbine blades. The advanced tip-seal system was designed to maintain close operating clearances between turbine blade tips and turbine shrouds and, at the same time, be resistant to environmental effects including high-temperature oxidation, hot corrosion, and thermal cycling. The turbine blade tip comprised an environmentally resistant, activated-diffussion-bonded, monocrystal superalloy combined with a thin layer of aluminium oxide abrasive particles entrapped in an electroplated NiCr matrix. The project established the tip design and joint location, characterized the single-crystal tip alloy and abrasive tip treatment, and established the manufacturing and quality-control plans required to fully process the blades. A total of 171 blades were fully manufactured, and 100 were endurance and performance engine-tested.

Gas turbine blade film cooling and blade tip heat transfer

NASA Astrophysics Data System (ADS)

Teng, Shuye

The detailed heat transfer coefficient and film cooling effectiveness distributions as well as the detailed coolant jet temperature profiles on the suction side of a gas turbine blade were measured using a transient liquid crystal image method and a traversing cold wire and thermocouple probe, respectively. The blade has only one row of film holes near the gill hole portion on the suction side of the blade. The hole geometries studied include standard cylindrical holes and holes with diffuser shaped exit portion (i.e. fanshaped holes and laidback fanshaped holes). Tests were performed on a five-blade linear cascade in a low-speed wind tunnel. The mainstream Reynolds number based on cascade exit velocity was 5.3 x 105. The upstream unsteady wakes were simulated using a spoke-wheel type wake generator. The wake Strouhal number was kept at 0 and 0.1. The coolant blowing ratio was varied from 0.4 to 1.2. Results show that both expanded holes have significantly improved thermal protection over the surface downstream of the ejection location, particularly at high blowing ratios. However, the expanded hole injections induce earlier boundary layer transition to turbulence and enhance heat transfer coefficients at the latter part of the blade suction surface. In general, the unsteady wake tends to reduce film cooling effectiveness. Measurements of detailed heat transfer coefficient distributions on a turbine blade tip were performed in the same wind tunnel facility as above. The central blade had a variable tip gap clearance. Measurements were made at three different tip gap clearances of about 1.1%, 2.1%, and 3% of the blade span. Static pressure distributions were measured in the blade mid-span and on the shroud surface. Detailed heat transfer coefficient distributions were measured on the blade tip surface. Results show that reduced tip clearance leads to reduced heat transfer coefficient over the blade tip surface. Results also show that reduced tip clearance tends to

Turbomachinery Clearance Control

NASA Technical Reports Server (NTRS)

Chupp, Raymond E.; Hendricks, Robert C.; Lattime, Scott B.; Steinetz, Bruce M.; Aksit, Mahmut F.

2007-01-01

Controlling interface clearances is the most cost effective method of enhancing turbomachinery performance. Seals control turbomachinery leakages, coolant flows and contribute to overall system rotordynamic stability. In many instances, sealing interfaces and coatings are sacrificial, like lubricants, giving up their integrity for the benefit of the component. They are subjected to abrasion, erosion, oxidation, incursive rubs, foreign object damage (FOD) and deposits as well as extremes in thermal, mechanical, aerodynamic and impact loadings. Tribological pairing of materials control how well and how long these interfaces will be effective in controlling flow. A variety of seal types and materials are required to satisfy turbomachinery sealing demands. These seals must be properly designed to maintain the interface clearances. In some cases, this will mean machining adjacent surfaces, yet in many other applications, coatings are employed for optimum performance. Many seals are coating composites fabricated on superstructures or substrates that are coated with sacrificial materials which can be refurbished either in situ or by removal, stripping, recoating and replacing until substrate life is exceeded. For blade and knife tip sealing an important class of materials known as abradables permit blade or knife rubbing without significant damage or wear to the rotating element while maintaining an effective sealing interface. Most such tip interfaces are passive, yet some, as for the high-pressure turbine (HPT) case or shroud, are actively controlled. This work presents an overview of turbomachinery sealing. Areas covered include: characteristics of gas and steam turbine sealing applications and environments, benefits of sealing, types of standard static and dynamics seals, advanced seal designs, as well as life and limitations issues.

A Blade Tip Timing Method Based on a Microwave Sensor

PubMed Central

Zhang, Jilong; Duan, Fajie; Niu, Guangyue; Jiang, Jiajia; Li, Jie

2017-01-01

Blade tip timing is an effective method for blade vibration measurements in turbomachinery. This method is increasing in popularity because it is non-intrusive and has several advantages over the conventional strain gauge method. Different kinds of sensors have been developed for blade tip timing, including optical, eddy current and capacitance sensors. However, these sensors are unsuitable in environments with contaminants or high temperatures. Microwave sensors offer a promising potential solution to overcome these limitations. In this article, a microwave sensor-based blade tip timing measurement system is proposed. A patch antenna probe is used to transmit and receive the microwave signals. The signal model and process method is analyzed. Zero intermediate frequency structure is employed to maintain timing accuracy and dynamic performance, and the received signal can also be used to measure tip clearance. The timing method uses the rising and falling edges of the signal and an auto-gain control circuit to reduce the effect of tip clearance change. To validate the accuracy of the system, it is compared experimentally with a fiber optic tip timing system. The results show that the microwave tip timing system achieves good accuracy. PMID:28492469

A Blade Tip Timing Method Based on a Microwave Sensor.

PubMed

Zhang, Jilong; Duan, Fajie; Niu, Guangyue; Jiang, Jiajia; Li, Jie

2017-05-11

Blade tip timing is an effective method for blade vibration measurements in turbomachinery. This method is increasing in popularity because it is non-intrusive and has several advantages over the conventional strain gauge method. Different kinds of sensors have been developed for blade tip timing, including optical, eddy current and capacitance sensors. However, these sensors are unsuitable in environments with contaminants or high temperatures. Microwave sensors offer a promising potential solution to overcome these limitations. In this article, a microwave sensor-based blade tip timing measurement system is proposed. A patch antenna probe is used to transmit and receive the microwave signals. The signal model and process method is analyzed. Zero intermediate frequency structure is employed to maintain timing accuracy and dynamic performance, and the received signal can also be used to measure tip clearance. The timing method uses the rising and falling edges of the signal and an auto-gain control circuit to reduce the effect of tip clearance change. To validate the accuracy of the system, it is compared experimentally with a fiber optic tip timing system. The results show that the microwave tip timing system achieves good accuracy.

Toward Understanding Tip Leakage Flows in Small Compressor Cores Including Stator Leakage Flow

NASA Technical Reports Server (NTRS)

Berdanier, Reid A.; Key, Nicole L.

2017-01-01

The focus of this work was to provide additional data to supplement the work reported in NASA/CR-2015-218868 (Berdanier and Key, 2015b). The aim of that project was to characterize the fundamental flow physics and the overall performance effects due to increased rotor tip clearance heights in axial compressors. Data have been collected in the three-stage axial research compressor at Purdue University with a specific focus on analyzing the multistage effects resulting from the tip leakage flow. Three separate rotor tip clearances were studied with nominal tip clearance gaps of 1.5 percent, 3.0 percent, and 4.0 percent based on a constant annulus height. Overall compressor performance was previously investigated at four corrected speedlines (100 percent, 90 percent, 80 percent, and 68 percent) for each of the three tip clearance configurations. This study extends the previously published results to include detailed steady and time-resolved pressure data at two loading conditions, nominal loading (NL) and high loading (HL), on the 100 percent corrected speedline for the intermediate clearance level (3.0 percent). Steady detailed radial traverses of total pressure at the exit of each stator row are supported by flow visualization techniques to identify regions of flow recirculation and separation. Furthermore, detailed radial traverses of time-resolved total pressures at the exit of each rotor row have been measured with a fast-response pressure probe. These data were combined with existing three-component velocity measurements to identify a novel technique for calculating blockage in a multistage compressor. Time-resolved static pressure measurements have been collected over the rotor tips for all rotors with each of the three tip clearance configurations for up to five loading conditions along the 100 percent corrected speedline using fast-response piezoresistive pressure sensors. These time-resolved static pressure measurements reveal new knowledge about the

Further Characterization of an Active Clearance Control Concept

NASA Technical Reports Server (NTRS)

Taylor, Shawn C.; Steinetz, Bruce M.; Oswald, Jay J.

2007-01-01

A new test chamber and precision hydraulic actuation system were incorporated into an active clearance control (ACC) test rig at NASA Glenn Research Center. Using the improved system, a fast-acting, mechanically-actuated, ACC concept was evaluated at engine simulated temperatures and pressure differentials up to 1140 F and 120 psig, on the basis of secondary seal leakage and kinematic controllability. During testing, the ACC concept tracked a simulated flight clearance transient profile at 1140 F, 120 psig, with a maximum error of only 0.0012 in. Comparison of average dynamic leakage of the system with average static leakage did not show significant differences between the two operating conditions. Calculated effective clearance values for the rig were approximately 0.0002 in. at 120 psig, well below the industry specified effective clearance threshold of 0.001 in.

Effect of tip clearance on performance of small axial hydraulic turbine

NASA Technical Reports Server (NTRS)

Boynton, J. L.; Rohlik, H. E.

1976-01-01

The first two stages of a six stage liquid oxygen turbine were tested in water. One and two stage performance was determined for one shrouded and two unshrouded blade end configurations over ranges of clearance and blade-jet speed ratio. First stage, two stage, and second stage efficiencies are included as well as the effect of clearance on mass flow for two stage operation.

CF6 High Pressure Compressor and Turbine Clearance Evaluations

NASA Technical Reports Server (NTRS)

Radomski, M. A.; Cline, L. D.

1981-01-01

In the CF6 Jet Engine Diagnostics Program the causes of performance degradation were determined for each component of revenue service engines. It was found that a significant contribution to performance degradation was caused by increased airfoil tip radial clearances in the high pressure compressor and turbine areas. Since the influence of these clearances on engine performance and fuel consumption is significant, it is important to accurately establish these relatonships. It is equally important to understand the causes of clearance deterioration so that they can be reduced or eliminated. The results of factory engine tests run to enhance the understanding of the high pressure compressor and turbine clearance effects on performance are described. The causes of clearance deterioration are indicated and potential improvements in clearance control are discussed.

Blood lactate clearance after maximal exercise depends on active recovery intensity.

PubMed

Devlin, J; Paton, B; Poole, L; Sun, W; Ferguson, C; Wilson, J; Kemi, O J

2014-06-01

High-intensity exercise is time-limited by onset of fatigue, marked by accumulation of blood lactate. This is accentuated at maximal, all-out exercise that rapidly accumulates high blood lactate. The optimal active recovery intensity for clearing lactate after such maximal, all-out exercise remains unknown. Thus, we studied the intensity-dependence of lactate clearance during active recovery after maximal exercise. We constructed a standardized maximal, all-out treadmill exercise protocol that predictably lead to voluntary exhaustion and blood lactate concentration>10 mM. Next, subjects ran series of all-out bouts that increased blood lactate concentration to 11.5±0.2 mM, followed by recovery exercises ranging 0% (passive)-100% of the lactate threshold. Repeated measurements showed faster lactate clearance during active versus passive recovery (P<0.01), and that active recovery at 60-100% of lactate threshold was more efficient for lactate clearance than lower intensity recovery (P<0.05). Active recovery at 80% of lactate threshold had the highest rate of and shortest time constant for lactate clearance (P<0.05), whereas the response during the other intensities was graded (100%=60%>40%>passive recovery, P<0.05). Active recovery after maximal all-out exercise clears accumulated blood lactate faster than passive recovery in an intensity-dependent manner, with maximum clearance occurring at active recovery of 80% of lactate threshold.

Free-Space Oscillating Pressures Near the Tips of Rotating Propellers

NASA Technical Reports Server (NTRS)

Hubbard, Harvey H; Regier, Arthur A

1950-01-01

The theory is given for calculating the free-space oscillating pressures associated with a rotating propeller, at any point in space. Because of its complexity this analysis is convenient only for use in the critical region near the propeller tips where the assumptions used by Gutin to simplify his final equations are not valid. Good agreement was found between analytical and experimental results in the tip Mach number range 0.45 to two, three, four, five, six, on eight-blade propellers and for a range of tip clearances from 0.04 to 0.30 times the propeller diameter. If the power coefficient, tip Mach number, and the tip clearance are known for a given propeller, the designer may determine from these charts the average maximum free-space oscillating pressure in the critical region near the plane of rotation. A section of the report is devoted to the fuselage response to these oscillating pressures and indicates some of the factors to be considered in solving the problems of fuselage vibration and noise.

Tips for Starting Physical Activity

MedlinePlus

... For Reporters Meetings & Workshops Follow Us Home Health Information Weight Management Tips to Help You Get Active Starting Physical ... at NIDDK Technology Advancement & Transfer Meetings & Workshops Health Information ... Disease Urologic Diseases Endocrine Diseases Diet & Nutrition ...

Effect of tip flange on tip leakage flow of small axial flow fans

NASA Astrophysics Data System (ADS)

Zhang, Li; Jin, Yingzi; Jin, Yuzhen

2014-02-01

Aerodynamic performance of an axial flow fan is closely related to its tip clearance leakage flow. In this paper, the hot-wire anemometer is used to measure the three dimensional mean velocity near the blade tips. Moreover, the filtered N-S equations with finite volume method and RNG k-ɛ turbulence model are adopted to carry out the steady simulation calculation of several fans that differ only in tip flange shape and number. The large eddy simulation and the FW-H noise models are adopted to carry out the unsteady numerical calculation and aerodynamic noise prediction. The results of simulation calculation agree roughly with that of tests, which proves the numerical calculation method is feasible.The effects of tip flange shapes and numbers on the blade tip vortex structure and the characteristics are analyzed. The results show that tip flange of the fan has a certain influence on the characteristics of the fan. The maximum efficiencies for the fans with tip flanges are shifted towards partial flow with respect to the design point of the datum fan. Furthermore, the noise characteristics for the fans with tip flanges have become more deteriorated than that for the datum fan. Tip flange contributes to forming tip vortex shedding and the effect of the half-cylinder tip flange on tip vortex shedding is obvious. There is a distinct relationship between the characteristics of the fan and tip vortex shedding. The research results provide the profitable reference for the internal flow mechanism of the performance optimization of small axial flow fans.

Mapping cavitation activity around dental ultrasonic tips.

PubMed

Walmsley, A Damien; Lea, Simon C; Felver, Bernhard; King, David C; Price, Gareth J

2013-05-01

Cavitation arising within the water around the oscillating ultrasonic scaler tip is an area that may lead to advances in enhancing biofilm removal. The aim of this study is to map the occurrence of cavitation around scaler tips under loaded conditions. Two designs of piezoelectric ultrasonic scaling probes were evaluated with a scanning laser vibrometer and luminol dosimetric system under loaded (100 g/200 g) and unloaded conditions. Loads were applied to the probe tips via teeth mounted in a load-measuring apparatus. There was a positive correlation between probe displacement amplitude and cavitation production for ultrasonic probes. The position of cavitation at the tip of each probe was greater under loaded conditions than unloaded and for the longer P probe towards the tip. Whilst increasing vibration displacement amplitude of ultrasonic scalers increases the occurrence of cavitation, factors such as the length of the probe influence the amount of cavitation activity generated. The application of load affects the production of cavitation at the most clinically relevant area-the tip. Loading and the design of ultrasonic scalers lead to maximising the occurrence of the cavitation at the tip and enhance the cleaning efficiency of the scaler.

Turbine Engine Clearance Control Systems: Current Practices and Future Directions

NASA Astrophysics Data System (ADS)

Lattime, Scott B.; Steinetz, Bruce M.

2002-09-01

Improved blade tip sealing in the high pressure compressor (HPC) and high pressure turbine (HPT) can provide dramatic reductions in specific fuel consumption (SFC), time-on-wing, compressor stall margin, and engine efficiency as well as increased payload and mission range capabilities. Maintenance costs to overhaul large commercial gas turbine engines can easily exceed 1M. Engine removal from service is primarily due to spent exhaust gas temperature (EGT) margin caused mainly by the deterioration of HPT components. Increased blade tip clearance is a major factor in hot section component degradation. As engine designs continue to push the performance envelope with fewer parts and the market drives manufacturers to increase service life, the need for advanced sealing continues to grow. A review of aero gas turbine engine HPT performance degradation and the mechanisms that promote these losses are discussed. Benefits to the HPT due to improved clearance management are identified. Past and present sealing technologies are presented along with specifications for next generation engine clearance control systems.

Turbine Engine Clearance Control Systems: Current Practices and Future Directions

NASA Technical Reports Server (NTRS)

Lattime, Scott B.; Steinetz, Bruce M.

2002-01-01

Improved blade tip sealing in the high pressure compressor (HPC) and high pressure turbine (HPT) can provide dramatic reductions in specific fuel consumption (SFC), time-on-wing, compressor stall margin, and engine efficiency as well as increased payload and mission range capabilities. Maintenance costs to overhaul large commercial gas turbine engines can easily exceed $1M. Engine removal from service is primarily due to spent exhaust gas temperature (EGT) margin caused mainly by the deterioration of HPT components. Increased blade tip clearance is a major factor in hot section component degradation. As engine designs continue to push the performance envelope with fewer parts and the market drives manufacturers to increase service life, the need for advanced sealing continues to grow. A review of aero gas turbine engine HPT performance degradation and the mechanisms that promote these losses are discussed. Benefits to the HPT due to improved clearance management are identified. Past and present sealing technologies are presented along with specifications for next generation engine clearance control systems.

Compressor blade clearance measurement using capacitance and phase lock techniques

NASA Astrophysics Data System (ADS)

Demers, Rosario N.

1986-11-01

The clearance measurement system has several unique features which mimimize problems plaguing earlier systems. These include tuning stability and sensitivity drift. Both these problems are intensified by the environmental factors present in compressors i.e., wide temperature fluctuations, vibrations, and conductive contamination of probe tips. The circuitry in this new system provides phase lock feedback to control tuning and shut calibration to measure sensitivity. The use of high frequency excitation lowers the probe tip impedance, thus miminizing the effects of contamination. A prototype has been built and tested. The ability to calibrate has been demonstrated. An eight channel system is now being constructed for use in the Compressor Research Facility at Wright-Patterson AFB. The efficiency of a turbine engine is to a large extent dependent upon the mechanical tolerances maintained between its moving parts. On critical tolerance is the blade span. Although this tolerance may not appear severe, the impact on compressor efficiency is dramatic. The penalty in percent efficiency has been shown to be three times the percent clearance to blade span ratio. In addition, each percent loss in compressor efficiency represents one half percent loss in specific fuel consumption. Factors which affect blade tip clearance are identified.

Rate-Based Model Predictive Control of Turbofan Engine Clearance

NASA Technical Reports Server (NTRS)

DeCastro, Jonathan A.

2006-01-01

An innovative model predictive control strategy is developed for control of nonlinear aircraft propulsion systems and sub-systems. At the heart of the controller is a rate-based linear parameter-varying model that propagates the state derivatives across the prediction horizon, extending prediction fidelity to transient regimes where conventional models begin to lose validity. The new control law is applied to a demanding active clearance control application, where the objectives are to tightly regulate blade tip clearances and also anticipate and avoid detrimental blade-shroud rub occurrences by optimally maintaining a predefined minimum clearance. Simulation results verify that the rate-based controller is capable of satisfying the objectives during realistic flight scenarios where both a conventional Jacobian-based model predictive control law and an unconstrained linear-quadratic optimal controller are incapable of doing so. The controller is evaluated using a variety of different actuators, illustrating the efficacy and versatility of the control approach. It is concluded that the new strategy has promise for this and other nonlinear aerospace applications that place high importance on the attainment of control objectives during transient regimes.

Performance of a Splittered Transonic Rotor with Several Tip Clearances

DTIC Science & Technology

2015-06-15

θ Ratio of inlet to reference pressure and γ [-] ρ Density [kg/m3] ω Humidity ratio [-] Subscripts 1 Inlet 3 Outlet a Air gas l Water liquid ...has a large influence on the performance and efficiency of compressors and fans during operation. In a gas turbine engine the ratio of tip-gap to...of compressors and fans during operation. In a gas turbine engine the ratio of tip-gap to blade height or span usually increases in the direction of

An investigation of rotor tip leakage flows in the rear-block of a multistage compressor

NASA Astrophysics Data System (ADS)

Brossman, John Richard

An effective method to improve gas turbine propulsive efficiency is to increase the bypass ratio. With fan diameter reaching a practical limit, increases in bypass ratio can be obtained from reduced core engine size. Decreasing the engine core, results in small, high pressure compressor blading, and large relative tip clearances. At general rule of 1% reduction in compressor efficiency with a 1% increase in tip clearance, a 0.66% change in SFC indicates the entire engine is sensitive to high pressure compressor tip leakage flows. Therefore, further investigations and understanding of the rotor tip leakage flows can help to improve gas turbine engine efficiency. The objectives of this research were to investigate tip leakage flows through computational modeling, examine the baseline experimental steady-stage performance, and acquire unsteady static pressure, over-the rotor to observe the tip leakage flow structure. While tip leakage flows have been investigated in the past, there have been no facilities capable of matching engine representative Reynolds number and Mach number while maintaining blade row interactions, presenting a unique and original flow field to investigate at the Purdue 3-stage axial compressor facility. To aid the design of experimental hardware and determine the influence of clearance geometry on compressor performance, a computational model of the Purdue 3-stage compressor was investigated using a steady RANS CFD analysis. A cropped rotor and casing recess design was investigated to increase the rotor tip clearance. While there were small performance differences between the geometries, the tip leakage flow field was found independent of the design therefore designing future experimental hardware around a casing recess is valid. The largest clearance with flow margin past the design point was 4% tip clearance based on the computational model. The Purdue 3-stage axial compressor facility was rebuilt and setup for high quality, detailed flow

CF6 jet engine diagnostics program. High pressure turbine roundness/clearance investigation

NASA Technical Reports Server (NTRS)

Howard, W. D.; Fasching, W. A.

1982-01-01

The effects of high pressure turbine clearance changes on engine and module performance was evaluated in addition to the measurement of CF6-50C high pressure turbine Stage 1 tip clearance and stator out-of-roundness during steady-state and transient operation. The results indicated a good correlation of the analytical model of round engine clearance response with measured data. The stator out-of-roundness measurements verified that the analytical technique for predicting the distortion effects of mechanical loads is accurate, whereas the technique for calculating the effects of certain circumferential thermal gradients requires some modifications. A potential for improvement in roundness was established in the order of 0.38 mm (0.015 in.), equivalent to 0.86 percent turbine efficiency which translates to a cruise SFC improvement of 0.36 percent. The HP turbine Stage 1 tip clearance performance derivative was established as 0.44 mm (17 mils) per percent of turbine efficiency at take-off power, somewhat smaller, therefore, more sensitive than predicted from previous investigations.

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Design, analysis, optimization and control of rotor tip flows

NASA Astrophysics Data System (ADS)

Maesschalck, Cis Guy M. De

Developments in turbomachinery focus on efficiency and reliability enhancements, while reducing the production costs. In spite of the many noteworthy experimental and numerical investigations over the past decades, the turbine tip design presents numerous challenges to the engine manufacturers, and remains the primary factor defining the machine durability for the periodic removal of the turbine components during overhaul. Due to the hot gases coming from the upstream combustion chamber, the turbine blades are subjected to temperatures far above the metal creep temperature, combined with severe thermal stresses induced within the blade material. Inadequate designs cause early tip burnouts leading to considerable performance degradations, or even a catastrophic turbine failure. Moreover, the leakage spillage, nowadays often exceeding the transonic regime, generates large aerodynamic penalties which are responsible for about one third of the turbine losses. In this view, the current doctoral research exploits the potential through the modification and optimization of the blade tip shape as a means to control the tip leakage flow aerodynamics and manage the heat load distribution over the blade profile to improve the turbine efficiency and durability. Three main design strategies for unshrouded turbine blade tips were analyzed and optimized: tight running clearances, blade tip contouring and the use of complex squealer-like geometries. The altered overtip flow physics and heat transfer characteristics were simulated for tight gap sizes as low as 0.5% down to 0.1% of the blade height, occurring during engine transients and soon to be expected due to recent developments in active clearance control strategies. The potential of fully 3D contoured blade top surfaces, allowing to adapt the profile locally to the changing flow conditions throughout the camberline, is quantified. First adopting a quasi-3D approach and subsequently using a full 3D optimization. For the

Numerical investigation of influence of tip leakage flow on secondary flow in transonic centrifugal compressor at design condition

NASA Astrophysics Data System (ADS)

Kaneko, Masanao; Tsujita, Hoshio

2015-04-01

In a centrifugal compressor, the leakage flow through the tip clearance generates the tip leakage vortex by the interaction with the main flow, and consequently makes the flow in the impeller passage more complex by the interaction with the passage vortex. In addition, the tip leakage vortex interacts with the shock wave on the suction surface near the blade tip in the transonic centrifugal compressor impeller. Therefore, the detailed examination for the influence of the tip leakage vortex becomes seriously important to improve the aerodynamic performance especially for the transonic centrifugal compressor. In this study, the flows in the transonic centrifugal compressor with and without the tip clearance at the design condition were analyzed numerically by using the commercial CFD code. The computed results revealed that the tip leakage vortex induced by the high loading at the blade tip around the leading edge affected the loss generation by the reduction or the suppression of the shock wave on the suction surface of the blade.

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Tips on Mainstreaming: Do's and Don'ts in Activity Programs.

ERIC Educational Resources Information Center

Practical Pointers, 1978

1978-01-01

The document provides 10 brief articles on activities for mainstreamed handicapped students. Included are the following titles: "Tips on Mainstreaminq--Do's and Don'ts for Activity Programs;""Mainstreaming--A Goal and A Process;""What To Do When You Meet a Handicapped Person;""Tips for Dealing with Handicapped Persons;""Relatinq to Orthopedically…

Turbine blade-tip clearance excitation forces

NASA Technical Reports Server (NTRS)

Martinez-Sanchez, M.; Greitzer, E. M.

1985-01-01

The results of an effort to assess the existing knowledge and plan the required experimentation in the area of turbine blade tip excitation forces is summarized. The work was carried out in three phases. The first was a literature search and evaluation, which served to highlight the state of the art and to expose the need for an articulated theoretical experimental effort to provide not only design data, but also a rational framework for their extrapolation to new configurations and regimes. The second phase was a start in this direction, in which several of the explicit or implicit assumptions contained in the usual formulations of the Alford force effect were removed and a rigorous linearized flow analysis of the behavior of a nonsymmetric actuator disc was carried out. In the third phase a preliminary design of a turbine test facility that would be used to measure both the excitation forces themselves and the flow patterns responsible for them were conducted and do so over a realistic range of dimensionless parameters.

Kaplan turbine tip vortex cavitation - analysis and prevention

NASA Astrophysics Data System (ADS)

Motycak, L.; Skotak, A.; Kupcik, R.

2012-11-01

The work is focused on one type of Kaplan turbine runner cavitation - a tip vortex cavitation. For detailed description of the tip vortex, the CFD analysis is used. On the basis of this analysis it is possible to estimate the intensity of cavitating vortex core, danger of possible blade surface and runner chamber cavitation pitting. In the paper, the ways how to avoid the pitting effect of the tip vortex are described. In order to prevent the blade surface against pitting, the following possibilities as the change of geometry of the runner blade, dimension of tip clearance and finally the installation of the anti-cavitation lips are discussed. The knowledge of the shape and intensity of the tip vortex helps to design the anti-cavitation lips more sophistically. After all, the results of the model tests of the Kaplan runner with or without anti-cavitation lips and the results of the CFD analysis are compared.

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Phosphorylation regulates the water channel activity of the seed-specific aquaporin alpha-TIP.

PubMed

Maurel, C; Kado, R T; Guern, J; Chrispeels, M J

1995-07-03

The vacuolar membrane protein alpha-TIP is a seed-specific protein of the Major Intrinsic Protein family. Expression of alpha-TIP in Xenopus oocytes conferred a 4- to 8-fold increase in the osmotic water permeability (Pf) of the oocyte plasma membrane, showing that alpha-TIP forms water channels and is thus a new aquaporin. alpha-TIP has three putative phosphorylation sites on the cytoplasmic side of the membrane (Ser7, Ser23 and Ser99), one of which (Ser7) has been shown to be phosphorylated. We present several lines of evidence that the activity of this aquaporin is regulated by phosphorylation. First, mutation of the putative phosphorylation sites in alpha-TIP (Ser7Ala, Ser23Ala and Ser99Ala) reduced the apparent water transport activity of alpha-TIP in oocytes, suggesting that phosphorylation of alpha-TIP occurs in the oocytes and participates in the control of water channel activity. Second, exposure of oocytes to the cAMP agonists 8-bromoadenosine 3',5'-cyclic monophosphate, forskolin and 3-isobutyl-1-methylxanthine, which stimulate endogenous protein kinase A (PKA), increased the water transport activity of alpha-TIP by 80-100% after 60 min. That the protein can be phosphorylated by PKA was demonstrated by phosphorylating alpha-TIP in isolated oocyte membranes with the bovine PKA catalytic subunit. Third, the integrity of the three sites at positions 7, 23 and 99 was necessary for the cAMP-dependent increase in the Pf of oocytes expressing alpha-TIP, as well as for in vitro phosphorylation of alpha-TIP. These findings demonstrate that the alpha-TIP water channel can be modulated via phosphorylation of Ser7, Ser23 and Ser99.(ABSTRACT TRUNCATED AT 250 WORDS)

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Active control of surge in centrifugal compressors using magnetic thrust bearing actuation

NASA Astrophysics Data System (ADS)

Sanadgol, Dorsa

This research presents a new method for active surge control in centrifugal compressors with unshrouded impellers using a magnetic thrust bearing to modulate the impeller tip clearance. Magnetic bearings offer the potential for active control of flow instabilities. This capability is highly dependent on the sensitivity of the compressor characteristics to blade tip clearance. If the position of the shaft can be actuated with sufficient authority and speed, the induced pressure modulation makes control of surge promising. The active nature of the magnetic bearing system makes the real-time static and dynamic positioning of the rotor and therefore modulation of the impeller tip clearance possible. A theoretical model is first established that describes the sensitivity of the centrifugal compressor characteristic curve to tip clearance variations induced by axial motion of the rotor. Results from simulation of the nonlinear model for a single stage high-speed centrifugal compressor show that using the proposed control method, mass flow and pressure oscillations associated with compressor surge are quickly suppressed with acceptable tip clearance excursions, typically less than 20% of the available clearance. It is shown that it is possible to produce adequate axial excursions in the clearance between the impeller blades and the adjacent stationary shroud using a magnetic thrust bearing with practical levels of drive voltage. This surge control method would allow centrifugal compressors to reliably and safely operate with a wider range than is currently done in the field. The principal advantage of the proposed approach over conventional surge control methods lies in that, in machines already equipped with magnetic bearing, the method can potentially be implemented by simply modifying controller software. This dispenses with the need to introduce additional hardware, permitting adaptation of existing machinery at virtually no cost. In addition, since the controller is

Emergency Department Medical Clearance of Patients with Psychiatric or Behavioral Emergencies, Part 1.

PubMed

Tucci, Veronica Theresa; Moukaddam, Nidal; Alam, Al; Rachal, James

2017-09-01

Patients presenting to the emergency department with mental illness or behavioral complaints merit workup for underlying physical conditions that can trigger, mimic, or worsen psychiatric symptoms. However, interdisciplinary consensus on medical clearance is lacking, leading to wide variations in quality of care and, quite often, poor medical care. Psychiatry and emergency medicine specialty guidelines support a tailored, customized approach. This article summarizes best-practice approaches to the medical clearance of patients with psychiatric illness, tips on history taking, system reviews, clinical or physical examination, and common pitfalls in the medical clearance process. Copyright © 2017 Elsevier Inc. All rights reserved.

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Progress on Shape Memory Alloy Actuator Development for Active Clearance Control

NASA Technical Reports Server (NTRS)

DeCastro, Jonathan; Melcher, Kevin; Noebe, Ronald

2006-01-01

Results of a numerical analysis evaluating the feasibility of high-temperature shape memory alloys (HTSMA) for active clearance control actuation in the high-pressure turbine section of a modern turbofan engine has been conducted. The prototype actuator concept considered here consists of parallel HTSMA wires attached to the shroud that is located on the exterior of the turbine case. A transient model of an HTSMA actuator was used to evaluate active clearance control at various operating points in a test bed aircraft engine simulation. For the engine under consideration, each actuator must be designed to counteract loads from 380 to 2000 lbf and displace at least 0.033 in. Design results show that an actuator comprised of 10 wires 2 in. in length is adequate for control at critical engine operating points and still exhibit acceptable failsafe operability and cycle life. A proportional-integral-derivative (PID) controller with integrator windup protection was implemented to control clearance amidst engine transients during a normal mission. Simulation results show that the control system exhibits minimal variability in clearance control performance across the operating envelope. The final actuator design is sufficiently small to fit within the limited space outside the high-pressure turbine case and is shown to consume only small amounts of bleed air to adequately regulate temperature.

Novel sensors to enable closed-loop active clearance control in gas turbine engines

NASA Astrophysics Data System (ADS)

Geisheimer, Jonathan; Holst, Tom

2014-06-01

Active clearance control within the turbine section of gas turbine engines presents and opportunity within aerospace and industrial applications to improve operating efficiencies and the life of downstream components. Open loop clearance control is currently employed during the development of all new large core aerospace engines; however, the ability to measure the gap between the blades and the case and close down the clearance further presents as opportunity to gain even greater efficiencies. The turbine area is one of the harshest environments for long term placement of a sensor in addition to the extreme accuracy requirements required to enable closed loop clearance control. This paper gives an overview of the challenges of clearance measurements within the turbine as well as discusses the latest developments of a microwave sensor designed for this application.

Investigation of Turbulent Tip Leakage Vortex in an Axial Water Jet Pump with Large Eddy Simulation

NASA Technical Reports Server (NTRS)

Hah, Chunill; Katz, Joseph

2012-01-01

Detailed steady and unsteady numerical studies were performed to investigate tip clearance flow in an axial water jet pump. The primary objective is to understand physics of unsteady tip clearance flow, unsteady tip leakage vortex, and cavitation inception in an axial water jet pump. Steady pressure field and resulting steady tip leakage vortex from a steady flow analysis do not seem to explain measured cavitation inception correctly. The measured flow field near the tip is unsteady and measured cavitation inception is highly transient. Flow visualization with cavitation bubbles shows that the leakage vortex is oscillating significantly and many intermittent vortex ropes are present between the suction side of the blade and the tip leakage core vortex. Although the flow field is highly transient, the overall flow structure is stable and a characteristic frequency seems to exist. To capture relevant flow physics as much as possible, a Reynolds-averaged Navier-Stokes (RANS) calculation and a Large Eddy Simulation (LES) were applied for the current investigation. The present study reveals that several vortices from the tip leakage vortex system cross the tip gap of the adjacent blade periodically. Sudden changes in local pressure field inside tip gap due to these vortices create vortex ropes. The instantaneous pressure filed inside the tip gap is drastically different from that of the steady flow simulation. Unsteady flow simulation which can calculate unsteady vortex motion is necessary to calculate cavitation inception accurately even at design flow condition in such a water jet pump.

Improved drainage with active chest tube clearance.

PubMed

Shiose, Akira; Takaseya, Tohru; Fumoto, Hideyuki; Arakawa, Yoko; Horai, Tetsuya; Boyle, Edward M; Gillinov, A Marc; Fukamachi, Kiyotaka

2010-05-01

This study was performed to evaluate the efficacy of a novel chest drainage system. This system employs guide wire-based active chest tube clearance to improve drainage and maintain patency. A 32 Fr chest tube was inserted into pleural cavities of five pigs. On the left, a tube was connected to the chest canister, and on the right, the new system was inserted between the chest tube and chest canister. Acute bleeding was mimicked by periodic infusion of blood. The amount of blood drained from each chest cavity was recorded every 15 min for 2 h. After completion of the procedure, all residual blood and clots in each chest cavity were assessed. The new system remained widely patent, and the amount of drainage achieved with this system (670+/-105 ml) was significantly (P=0.01) higher than that with the standard tube (239+/-131 ml). The amount of retained pleural blood and clots with this system (150+/-107 ml) was significantly (P=0.04) lower than that with the standard tube (571+/-248 ml). In conclusion, a novel chest drainage system with active tube clearance significantly improved drainage without tube manipulations. 2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.

Control of the Water Transport Activity of Barley HvTIP3;1 Specifically Expressed in Seeds.

PubMed

Utsugi, Shigeko; Shibasaka, Mineo; Maekawa, Masahiko; Katsuhara, Maki

2015-09-01

Tonoplast intrinsic proteins (TIPs) are involved in the transport and storage of water, and control intracellular osmotic pressure by transporting material related to the water potential of cells. In the present study, we focused on HvTIP3;1 during the periods of seed development and desiccation in barley. HvTIP3;1 was specifically expressed in seeds. An immunochemical analysis showed that HvTIP3;1 strongly accumulated in the aleurone layers and outer layers of barley seeds. The water transport activities of HvTIP3;1 and HvTIP1;2, which also accumulated in seeds, were measured in the heterologous expression system of Xenopus oocytes. When they were expressed individually, HvTIP1;2 transported water, whereas HvTIP3;1 did not. However, HvTIP3;1 exhibited water transport activity when co-expressed with HvTIP1;2 in oocytes, and this activity was higher than when HvTIP1;2 was expressed alone. This is the first report to demonstrate that the water permeability of a TIP aquaporin was activated when co-expressed with another TIP. The split-yellow fluorescent protein (YFP) system in onion cells revealed that HvTIP3;1 interacted with HvTIP1;2 to form a heterotetramer in plants. These results suggest that HvTIP3;1 functions as an active water channel to regulate water movement through tissues during the periods of seed development and desiccation. © The Author 2015. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

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Heat Transfer and Flow on the Squealer Tip of a Gas Turbine Blade

NASA Technical Reports Server (NTRS)

Azad, Gm S.; Han, Je-Chin; Boyle, Robert J.

2000-01-01

Experimental investigations are performed to measure the detailed heat transfer coefficient and static pressure distributions on the squealer tip of a gas turbine blade in a five-bladed stationary linear cascade. The blade is a 2-dimensional model of a modem first stage gas turbine rotor blade with a blade tip profile of a GE-E(sup 3) aircraft gas turbine engine rotor blade. A squealer (recessed) tip with a 3.77% recess is considered here. The data on the squealer tip are also compared with a flat tip case. All measurements are made at three different tip gap clearances of about 1%, 1.5%, and 2.5% of the blade span. Two different turbulence intensities of 6.1% and 9.7% at the cascade inlet are also considered for heat transfer measurements. Static pressure measurements are made in the mid-span and near-tip regions, as well as on the shroud surface opposite to the blade tip surface. The flow condition in the test cascade corresponds to an overall pressure ratio of 1.32 and an exit Reynolds number based on the axial chord of 1.1 x 10(exp 6). A transient liquid crystal technique is used to measure the heat transfer coefficients. Results show that the heat transfer coefficient on the cavity surface and rim increases with an increase in tip clearance. 'Me heat transfer coefficient on the rim is higher than the cavity surface. The cavity surface has a higher heat transfer coefficient near the leading edge region than the trailing edge region. The heat transfer coefficient on the pressure side rim and trailing edge region is higher at a higher turbulence intensity level of 9.7% over 6.1 % case. However, no significant difference in local heat transfer coefficient is observed inside the cavity and the suction side rim for the two turbulence intensities. The squealer tip blade provides a lower overall heat transfer coefficient when compared to the flat tip blade.

Turbine blade tip and seal clearance excitation forces

NASA Technical Reports Server (NTRS)

Martinez-Sanchez, M.; Jaroux, B.

1992-01-01

Experimental and theoretical work done as Phase 3 of a program sponsored by MSFC to investigate the magnitude, origin, and parametric variations of destabilizing forces which arise in high power turbines due to blade-tip leakage effects are described. The two facilities which were built for this purpose are first described. The larger one is a closed, 2 atm pressurized Freon-12 flow loop in which is installed a 1:1 replica of the SSME first stage hydrogen turbine, which can be driven by the flow, and which generates about 14 KW of power into a load-absorbing DC generator. The smaller facility is used to measure the forces on labyrinth seals of the same type as those used in our turbine tests with a shrouded turbine. The seals can be kinematically whirled and spun (independently), and the inlet swirl can be set to a variety of values. Air is the working fluid (with atmospheric discharge) and the data are real-time pressure distributions in the seal glands. The five different unshrouded turbine configurations were tested with static offsets, plus one with a shroud band and a two-ridge seal. Theoretical models of various degrees of complexity were developed to help interpreting and extrapolating the data. The notion of partial work done by the fluid leaking through the tip gaps was put on a quantitative basis by examining the leakage vortex roll-up dynamics. This was used to obtain a theory of the work loss due to a uniform gap. Perturbation and multiple scale arguments were then used to extend this to the case of an eccentric turbine. This yields an unsteady, 3-D theory which can predict the distribution of the approach flow, and its effect on work defect, cross-forces, pressure patterns, and dynamic damping. The predictions agree qualitatively with the data and exhibit the correct trends, but the cross-forces are generally under-predicted.

Radioaerosol lung clearance in patients with active pulmonary sarcoidosis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jacobs, M.P.; Baughman, R.P.; Hughes, J.

1985-05-01

Pulmonary radioaerosol clearance rate of /sup 99m/Tc diethylenetriamine pentacetate (DTPA) in 14 patients with untreated sarcoidosis was compared with /sup 67/Ga lung scan and increased lymphocytes in the bronchoalveolar lavage (BAL) fluid. Nine healthy nonsmoking subjects had a mean DTPA clearance rate of 1.18%/min (range, 0.54 to 1.60%/min). Eight of 14 patients with sarcoidosis had clearance rates greater than 1.60%/min. Of those 8 patients with abnormal DTPA clearance, 4 had positive gallium scans, 4 had more than 17% lymphocytes in the BAL fluid, and 3 had both tests positive. To study the cause of abnormal DTPA clearance, 23 subjects (includingmore » 3 normal controls, all 14 patients with sarcoidosis, and 6 patients with localized disease on chest roentgenogram) underwent both DTPA clearance studies and BAL for quantitation of the amount of albumin in lung fluid. There was a positive correlation between the rate of DTPA clearance and the albumin concentration in lung fluid (r = 0.87, p less than 0.01).« less

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Tip Vortex and Wake Characteristics of a Counterrotating Open Rotor

NASA Technical Reports Server (NTRS)

VanZante, Dale E.; Wernet, Mark P.

2012-01-01

One of the primary noise sources for Open Rotor systems is the interaction of the forward rotor tip vortex and blade wake with the aft rotor. NASA has collaborated with General Electric on the testing of a new generation of low noise, counterrotating Open Rotor systems. Three-dimensional particle image velocimetry measurements were acquired in the intra-rotor gap of the Historical Baseline blade set. The velocity measurements are of sufficient resolution to characterize the tip vortex size and trajectory as well as the rotor wake decay and turbulence character. The tip clearance vortex trajectory is compared to results from previously developed models. Forward rotor wake velocity profiles are shown. Results are presented in a form as to assist numerical modeling of Open Rotor system aerodynamics and acoustics.

Tip Vortex Cavitation

NASA Astrophysics Data System (ADS)

Maines, Brant H.; Arndt, Roger E. A.

2000-11-01

Cavitation in vortical flows is a problem of practical importance, that is relatively unexplored. Vortical structures of importance range from the eddies occurring randomly in space and time in turbulent flows to the developed vortices that occur at the tips of lifting surfaces and at the hubs of propellers and hydraulic turbines. A variety of secondary flow phenomena such as the horse shoe vortices that form around bridge piers, chute blocks and struts, and the secondary vortices found in the clearance passages of turbomachinery are also important cavitation sites. Tip vortex cavitation can be viewed as a canonical problem that captures many of the essential physics associated with vortex cavitation in general. This paper describes the inception process and focuses on the high levels of tension that can be sustained in the flow, which appears to scale with the blade loading. High speed video visualization indicates that the details of how free stream nuclei are ingested plays a major role in the nucleation and inception process. A new photographic technique was used to obtain high quality images of the bubble growth process at framing rates as high as 40,000 fps. Sponsored by the Office of Naval Research

Phosphatidylserine-mediated platelet clearance by endothelium decreases platelet aggregates and procoagulant activity in sepsis.

PubMed

Ma, Ruishuang; Xie, Rui; Yu, Chengyuan; Si, Yu; Wu, Xiaoming; Zhao, Lu; Yao, Zhipeng; Fang, Shaohong; Chen, He; Novakovic, Valerie; Gao, Chunyan; Kou, Junjie; Bi, Yayan; Thatte, Hemant S; Yu, Bo; Yang, Shufen; Zhou, Jin; Shi, Jialan

2017-07-10

The mechanisms that eliminate activated platelets in inflammation-induced disseminated intravascular coagulation (DIC) in micro-capillary circulation are poorly understood. This study explored an alternate pathway for platelet disposal mediated by endothelial cells (ECs) through phosphatidylserine (PS) and examined the effect of platelet clearance on procoagulant activity (PCA) in sepsis. Platelets in septic patients demonstrated increased levels of surface activation markers and apoptotic vesicle formation, and also formed aggregates with leukocytes. Activated platelets adhered were and ultimately digested by ECs in vivo and in vitro. Blocking PS on platelets or αvβ3 integrin on ECs attenuated platelet clearance resulting in increased platelet count in a mouse model of sepsis. Furthermore, platelet removal by ECs resulted in a corresponding decrease in platelet-leukocyte complex formation and markedly reduced generation of factor Xa and thrombin on platelets. Pretreatment with lactadherin significantly increased phagocytosis of platelets by approximately 2-fold, diminished PCA by 70%, prolonged coagulation time, and attenuated fibrin formation by 50%. Our results suggest that PS-mediated clearance of activated platelets by the endothelium results in an anti-inflammatory, anticoagulant, and antithrombotic effect that contribute to maintaining platelet homeostasis during acute inflammation. These results suggest a new therapeutic target for impeding the development of DIC.

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Prediction of destabilizing blade tip forces for shrouded and unshrouded turbines

NASA Technical Reports Server (NTRS)

Qiu, Y. J.; Martinezsanchez, M.

1985-01-01

The effect of a nonuniform flow field on the Alford force calculation is investigated. The ideas used here are based on those developed by Horlock and Greitzer. It is shown that the nonuniformity of the flow field does contribute to the Alford force calculation. An attempt is also made to include the effect of whirl speed. The values predicted by the model are compared with those obtained experimentally by Urlicks and Wohlrab. The possibility of using existing turbine tip loss correlations to predict beta is also exploited. The nonuniform flow field induced by the tip clearnance variation tends to increase the resultant destabilizing force over and above what would be predicted on the basis of the local variation of efficiency. On the one hand, the pressure force due to the nonuniform inlet and exit pressure also plays a part even for unshrouded blades, and this counteracts the flow field effects, so that the simple Alford prediction remains a reasonable approximation. Once the efficiency variation with clearance is known, the presented model gives a slightly overpredicted, but reasonably accurate destabilizing force. In the absence of efficiency vs. clearance data, an empirical tip loss coefficient can be used to give a reasonable prediction of destabilizing force. To a first approximation, the whirl does have a damping effect, but only of small magnitude, and thus it can be ignored for some purposes.

Early lactate clearance for predicting active bleeding in critically ill patients with acute upper gastrointestinal bleeding: a retrospective study.

PubMed

Wada, Tomoki; Hagiwara, Akiyoshi; Uemura, Tatsuki; Yahagi, Naoki; Kimura, Akio

2016-08-01

Not all patients with upper gastrointestinal bleeding (UGIB) require emergency endoscopy. Lactate clearance has been suggested as a parameter for predicting patient outcomes in various critical care settings. This study investigates whether lactate clearance can predict active bleeding in critically ill patients with UGIB. This single-center, retrospective, observational study included critically ill patients with UGIB who met all of the following criteria: admission to the emergency department (ED) from April 2011 to August 2014; had blood samples for lactate evaluation at least twice during the ED stay; and had emergency endoscopy within 6 h of ED presentation. The main outcome was active bleeding detected with emergency endoscopy. Classification and regression tree (CART) analyses were performed using variables associated with active bleeding to derive a prediction rule for active bleeding in critically ill UGIB patients. A total of 154 patients with UGIB were analyzed, and 31.2 % (48/154) had active bleeding. In the univariate analysis, lactate clearance was significantly lower in patients with active bleeding than in those without active bleeding (13 vs. 29 %, P < 0.001). Using the CART analysis, a prediction rule for active bleeding is derived, and includes three variables: lactate clearance; platelet count; and systolic blood pressure at ED presentation. The rule has 97.9 % (95 % CI 90.2-99.6 %) sensitivity with 32.1 % (28.6-32.9 %) specificity. Lactate clearance may be associated with active bleeding in critically ill patients with UGIB, and may be clinically useful as a component of a prediction rule for active bleeding.

Validation of mercury tip-switch and accelerometer activity sensors for identifying resting and active behavior in bears

USGS Publications Warehouse

Jasmine Ware,; Rode, Karyn D.; Pagano, Anthony M.; Bromaghin, Jeffrey F.; Robbins, Charles T.; Joy Erlenbach,; Shannon Jensen,; Amy Cutting,; Nicole Nicassio-Hiskey,; Amy Hash,; Owen, Megan A.; Heiko Jansen,

2015-01-01

Activity sensors are often included in wildlife transmitters and can provide information on the behavior and activity patterns of animals remotely. However, interpreting activity-sensor data relative to animal behavior can be difficult if animals cannot be continuously observed. In this study, we examined the performance of a mercury tip-switch and a tri-axial accelerometer housed in collars to determine whether sensor data can be accurately classified as resting and active behaviors and whether data are comparable for the 2 sensor types. Five captive bears (3 polar [Ursus maritimus] and 2 brown [U. arctos horribilis]) were fitted with a collar specially designed to internally house the sensors. The bears’ behaviors were recorded, classified, and then compared with sensor readings. A separate tri-axial accelerometer that sampled continuously at a higher frequency and provided raw acceleration values from 3 axes was also mounted on the collar to compare with the lower resolution sensors. Both accelerometers more accurately identified resting and active behaviors at time intervals ranging from 1 minute to 1 hour (≥91.1% accuracy) compared with the mercury tip-switch (range = 75.5–86.3%). However, mercury tip-switch accuracy improved when sampled at longer intervals (e.g., 30–60 min). Data from the lower resolution accelerometer, but not the mercury tip-switch, accurately predicted the percentage of time spent resting during an hour. Although the number of bears available for this study was small, our results suggest that these activity sensors can remotely identify resting versus active behaviors across most time intervals. We recommend that investigators consider both study objectives and the variation in accuracy of classifying resting and active behaviors reported here when determining sampling interval.

Emergency Department Medical Clearance of Patients with Psychiatric or Behavioral Emergencies, Part 2: Special Psychiatric Populations and Considerations.

PubMed

Alam, Al; Rachal, James; Tucci, Veronica Theresa; Moukaddam, Nidal

2017-09-01

Patients who present to the emergency department (ED) with mental illness or behavioral complaints merit workup for underlying physical conditions that can trigger, mimic, or worsen psychiatric symptoms. However, there are wide variations in quality of care for these individuals. Psychiatry and emergency medicine specialty guidelines support a tailored, customized approach to patients. Our group has long advocated a dynamic comanagement approach for medical clearance in the ED, and this article summarizes best-practice approaches to the medical clearance of patients with psychiatric illness, tips on history taking, system reviews, clinical/physical examination, and common pitfalls in the medical clearance process. Copyright © 2017 Elsevier Inc. All rights reserved.

Predicting mountain lion activity using radiocollars equipped with mercury tip-sensors

USGS Publications Warehouse

Janis, Michael W.; Clark, Joseph D.; Johnson, Craig

1999-01-01

Radiotelemetry collars with tip-sensors have long been used to monitor wildlife activity. However, comparatively few researchers have tested the reliability of the technique on the species being studied. To evaluate the efficacy of using tip-sensors to assess mountain lion (Puma concolor) activity, we radiocollared 2 hand-reared mountain lions and simultaneously recorded their behavior and the associated telemetry signal characteristics. We noted both the number of pulse-rate changes and the percentage of time the transmitter emitted a fast pulse rate (i.e., head up) within sampling intervals ranging from 1-5 minutes. Based on 27 hours of observations, we were able to correctly distinguish between active and inactive behaviors >93% of the time using a logistic regression model. We present several models to predict activity of mountain lions; the selection of which to us would depend on study objectives and logistics. Our results indicate that field protocols that use only pulse-rate changes to indicate activity can lead to significant classification errors.

Application of winglets and/or wing tip extensions with active load control on the Boeing 747

NASA Technical Reports Server (NTRS)

Allison, R. L.; Perkin, B. R.; Schoenman, R. L.

1978-01-01

The application of wing tip modifications and active control technology to the Boeing 747 airplane for the purpose of improving fuel efficiency is considered. Wing tip extensions, wing tip winglets, and the use of the outboard ailerons for active wing load alleviation are described. Modest performance improvements are indicated. A costs versus benefits approach is taken to decide which, if any, of the concepts warrant further development and flight test leading to possible incorporation into production airplanes.

Active clearance control system for a turbomachine

NASA Technical Reports Server (NTRS)

Johnston, R. P.; Knapp, M. H.; Coulson, C. E. (Inventor)

1982-01-01

An axial compressor is provided with a cooling air manifold surrounding a portion of the shroud, and means for bleeding air from the compressor to the manifold for selectively flowing it in a modulating manner axially along the outer side of the stator/shroud to cool and shrink it during steady state operating conditions so as to obtain minimum shroud/rotor clearance conditions. Provision is also made to selectively divert the flow of cooling air from the manifold during transient periods of operation so as to alter the thermal growth or shrink rate of the stator/shroud and result in adequate clearance with the compressor rotor.

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Experimental performance of a 13.65-centimeter-tip-diameter tandem-bladed sweptback centrifugal compressor designed for a pressure ratio of 6

NASA Technical Reports Server (NTRS)

Klassen, H. A.; Wood, J. R.; Schumann, L. F.

1977-01-01

A 13.65 cm tip diameter backswept centrifugal impeller having a tandem inducer and a design mass flow rate of 0.907 kg/sec was experimentally investigated to establish stage and impeller characteristics. Tests were conducted with both a cascade diffuser and a vaneless diffuser. A pressure ratio of 5.9 was obtained near surge for the smallest clearance tested. Flow range at design speed was 6.3 percent for the smallest clearance test. Impeller exit to shroud axial clearance at design speed was varied to determine the effect on stage and impeller performance.

New digital capacitive measurement system for blade clearances

NASA Astrophysics Data System (ADS)

Moenich, Marcel; Bailleul, Gilles

This paper presents a totally new concept for tip blade clearance evaluation in turbine engines. This system is able to detect exact 'measurands' even under high temperature and severe conditions like ionization. The system is based on a heavy duty probe head, a miniaturized thick-film hybrid electronic circuit and a signal processing unit for real time computing. The high frequency individual measurement values are digitally filtered and linearized in real time. The electronic is built in hybrid technology and therefore can be kept extremely small and robust, so that the system can be used on actual flights.

Understanding and Mitigating Tip Leakage and Endwall Losses in High Pressure Ratio Cores

NASA Technical Reports Server (NTRS)

Christophel, Jesse

2015-01-01

Reducing endwall and tip secondary flow losses will be a key enabler for the next generation of commercial and military air transport and will be an improvement on the state-of-the-art in turbine loss reduction strategies. The objective of this research is three-fold: 1) To improve understanding of endwall secondary flow and tip clearance losses 2) To develop novel technologies to mitigate these losses and test them in low-speed cascade and rig environments 3) To validate predictive tools To accomplish these objectives, Pratt & Whitney (P&W) has teamed with Pennsylvania State University (PSU) to experimentally test new features designed by P&W. P&W will create new rim-cavity features to reduce secondary flow loss and improve purge flow cooling effectiveness and new blade tip features to manage leakage flows and reduce tip leakage secondary flow loss. P&W is currently developing technologies in these two areas that expect to be assimilated in the N+2/N+3 generation of commercial engines.

Pollen-tube tip growth requires a balance of lateral propagation and global inhibition of Rho-family GTPase activity

PubMed Central

Hwang, Jae-Ung; Wu, Guang; Yan, An; Lee, Yong-Jik; Grierson, Claire S.; Yang, Zhenbiao

2010-01-01

Rapid tip growth allows for efficient development of highly elongated cells (e.g. neuronal axons, fungal hyphae and pollen tubes) and requires an elaborate spatiotemporal regulation of the growing region. Here, we use the pollen tube as a model to investigate the mechanism regulating the growing region. ROPs (Rho-related GTPases from plants) are essential for pollen tip growth and display oscillatory activity changes in the apical plasma membrane (PM). By manipulating the ROP activity level, we showed that the PM distribution of ROP activity as an apical cap determines the tip growth region and that efficient tip growth requires an optimum level of the apical ROP1 activity. Excessive ROP activation induced the enlargement of the tip growth region, causing growth depolarization and reduced tube elongation. Time-lapse analysis suggests that the apical ROP1 cap is generated by lateral propagation of a localized ROP activity. Subcellular localization and gain- and loss-of-function analyses suggest that RhoGDI- and RhoGAP-mediated global inhibition limits the lateral propagation of apical ROP1 activity. We propose that the balance between the lateral propagation and the global inhibition maintains an optimal apical ROP1 cap and generates the apical ROP1 activity oscillation required for efficient pollen-tube elongation. PMID:20053639

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Physiological and Microfluorometric Studies of Reduction and Clearance of Retinal in Bleached Rod Photoreceptors

PubMed Central

Tsina, Efthymia; Chen, Chunhe; Koutalos, Yiannis; Ala-Laurila, Petri; Tsacopoulos, Marco; Wiggert, Barbara; Crouch, Rosalie K.; Cornwall, M. Carter

2004-01-01

The visual cycle comprises a sequence of reactions that regenerate the visual pigment in photoreceptors during dark adaptation, starting with the reduction of all-trans retinal to all-trans retinol and its clearance from photoreceptors. We have followed the reduction of retinal and clearance of retinol within bleached outer segments of red rods isolated from salamander retina by measuring its intrinsic fluorescence. Following exposure to a bright light (bleach), increasing fluorescence intensity was observed to propagate along the outer segments in a direction from the proximal region adjacent to the inner segment toward the distal tip. Peak retinol fluorescence was achieved after ∼30 min, after which it declined very slowly. Clearance of retinol fluorescence is considerably accelerated by the presence of the exogenous lipophilic substances IRBP (interphotoreceptor retinoid binding protein) and serum albumin. We have used simultaneous fluorometric and electrophysiological measurements to compare the rate of reduction of all-trans retinal to all-trans retinol to the rate of recovery of flash response amplitude in these cells in the presence and absence of IRBP. We find that flash response recovery in rods is modestly accelerated in the presence of extracellular IRBP. These results suggest such substances may participate in the clearance of retinoids from rod photoreceptors, and that this clearance, at least in rods, may facilitate dark adaptation by accelerating the clearance of photoproducts of bleaching. PMID:15452202

25-Gauge active aspiration silicon tip-assisted removal of glass and other intraocular foreign bodies.

PubMed

Singh, Ramandeep; Kumar, Abiraj; Gupta, Vishali; Dogra, Mangat R

2016-04-01

To describe the use of 25-gauge active aspiration silicon tip in removal of intraocular foreign bodies, including glass. Retrospective, noncomparative, interventional study. Eleven eyes of 11 patients who underwent the procedure between January 2013 and April 2015. The study included 10 males and 1 female with a mean age of 31.27 ± 9.64 years (range 12-45 years). All eyes in which 25-gauge active aspiration silicon tip-assisted removal of intraocular foreign body (IOFB) was done in a sutureless vitrectomy setup, irrespective of the nature of IOFB, were included. We excluded the participants with less than 6 months of postoperative follow-up. The primary outcome of the study was to assess the feasibility and reproducibility of 25-gauge active aspiration silicon tip-assisted removal of IOFB. The secondary outcome measures included change in best-corrected visual acuity (BCVA), and intraoperative and postoperative complications. There were iron (6), glass (2), wooden (1), pellet (1), and stone (1) IOFBs, for which 25-gauge active aspiration silicon tip-assisted removal was done successfully. The mean BCVA in Snellen's decimal equivalent improved significantly from 0.14 ± 0.16 to 0.34 ± 0.36 with a mean follow-up of 12 months (range 6-24 months). Intraoperatively, drop of IOFB because of loss of vacuum was observed in 2 eyes. Postoperatively, cystoid macular edema with epiretinal membrane was seen in 1 eye. There were no other intraoperative and postoperative complications. Use of 25-gauge active aspiration silicon tip to assist removal of magnetic and nonmagnetic IOFBs is a feasible and reproducible procedure, and required instrumentation is readily available in present-day vitrectomy era. Copyright © 2016 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.

CF6 Jet Engine Performance Improvement: High Pressure Turbine Active Clearance Control

NASA Technical Reports Server (NTRS)

Rich, S. E.; Fasching, W. A.

1982-01-01

An active clearance control system was developed which reduces fuel consumption and performance degradation. This system utilizes compressor discharge air during takeoff and fan discharge air during cruise to impinge on the shroud structure to improve the thermal response. The system was evaluated in component and engine tests. The test results demonstrated a performance improvement of 0.7 percent in cruise SFC.

Energy dissipation in the blade tip region of an axial fan

NASA Astrophysics Data System (ADS)

Bizjan, B.; Milavec, M.; Širok, B.; Trenc, F.; Hočevar, M.

2016-11-01

A study of velocity and pressure fluctuations in the tip clearance flow of an axial fan is presented in this paper. Two different rotor blade tip designs were investigated: the standard one with straight blade tips and the modified one with swept-back tip winglets. Comparison of integral sound parameters indicates a significant noise level reduction for the modified blade tip design. To study the underlying mechanisms of the energy conversion and noise generation, a novel experimental method based on simultaneous measurements of local flow velocity and pressure has also been developed and is presented here. The method is based on the phase space analysis by the use of attractors, which enable more accurate identification and determination of the local flow structures and turbulent flow properties. Specific gap flow energy derived from the pressure and velocity time series was introduced as an additional attractor parameter to assess the flow energy distribution and dissipation within the phase space, and thus determines characteristic sources of the fan acoustic emission. The attractors reveal a more efficient conversion of the pressure to kinetic flow energy in the case of the modified (tip winglet) fan blade design, and also a reduction in emitted noise levels. The findings of the attractor analysis are in a good agreement with integral fan characteristics (efficiency and noise level), while offering a much more accurate and detailed representation of gap flow phenomena.

A Numerical Analysis of Heat Transfer and Effectiveness on Film Cooled Turbine Blade Tip Models

NASA Technical Reports Server (NTRS)

Ameri, A. A.; Rigby, D. L.

1999-01-01

A computational study has been performed to predict the distribution of convective heat transfer coefficient on a simulated blade tip with cooling holes. The purpose of the examination was to assess the ability of a three-dimensional Reynolds-averaged Navier-Stokes solver to predict the rate of tip heat transfer and the distribution of cooling effectiveness. To this end, the simulation of tip clearance flow with blowing of Kim and Metzger was used. The agreement of the computed effectiveness with the data was quite good. The agreement with the heat transfer coefficient was not as good but improved away from the cooling holes. Numerical flow visualization showed that the uniformity of wetting of the surface by the film cooling jet is helped by the reverse flow due to edge separation of the main flow.

Intelligent Engine Systems: HPT Clearance Control

NASA Technical Reports Server (NTRS)

2008-01-01

The Advanced Thermally Actuated Clearance Control System underwent several studies. Improved flow path isolation quantified what can be gained by making the HPT case nearly adiabatic. The best method of heat transfer was established, and finally two different borrowed air cooling circuits were evaluated to be used for the HPT Active Clearance Control System.

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Tip-enhanced Raman scattering microscopy: Recent advance in tip production

NASA Astrophysics Data System (ADS)

Fujita, Yasuhiko; Walke, Peter; De Feyter, Steven; Uji-i, Hiroshi

2016-08-01

Tip-enhanced Raman scattering (TERS) microscopy is a technique that combines the chemical sensitivity of Raman spectroscopy with the resolving power of scanning probe microscopy. The key component of any TERS setup is a plasmonically-active noble metal tip, which serves to couple far-field incident radiation with the near-field. Thus, the design and implementation of reproducible probes are crucial for the continued development of TERS as a tool for nanoscopic analysis. Here we discuss conventional methods for the fabrication of TERS-ready tips, highlighting the problems therein, as well as detailing more recent developments to improve reducibility. In addition, the idea of remote excitation-TERS is enlightened upon, whereby TERS sensitivity is further improved by using propagating surface plasmons to separate the incident radiation from the tip apex, as well as how this can be incorporated into the fabrication process.

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Hepatic drug clearance following traumatic injury.

PubMed

Slaughter, R L; Hassett, J M

1985-11-01

Trauma is a complex disease state associated with physiologic changes that have the potential to alter hepatic drug clearance mechanisms. These responses include alterations in hepatic blood flow, reduction in hepatic microsomal activity, reduction in hepatic excretion processes, and changes in protein binding. Hepatic blood flow is influenced by sympathomimetic activity. Both animal and human studies demonstrate an initial reduction and subsequent increase in hepatic blood flow, which coincides with an observed increase and subsequent return to normal in serum catecholamine concentrations. Unfortunately, there are no human studies that address the importance these findings may have to the clearance processes of high intrinsic clearance compounds. Animal studies of trauma indicate that hepatic microsomal activity is depressed during the post-traumatic period. Reduction in the hepatic clearance of antipyrine, a model low intrinsic compound, has also been demonstrated in animal models of trauma. In addition to these effects, hepatic excretion of substances such as indocyanine green and bilirubin have been demonstrated to be impaired in both traumatized animals and humans. Finally, substantial increases in the serum concentration of the binding protein alpha 1-acid glycoprotein occur in trauma patients. This has been reported to be associated with subsequent decreases in the free fraction of lidocaine and quinidine. In addition to changing serum drug concentration/response relationships, the pharmacokinetic behavior of drugs bound to alpha 1-acid glycoprotein should also change. Preliminary observations in our laboratory in a dog model of surgically-induced trauma have shown a reduction in the total clearance of lidocaine and reduction in free lidocaine concentration.(ABSTRACT TRUNCATED AT 250 WORDS)

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... Request; Generic Clearance for the Collection of Qualitative Feedback on Agency Service Delivery AGENCY... Clearance for the Collection of Qualitative Feedback on Agency Service Delivery'' to OMB for approval under...: Title: Generic Clearance for the Collection of Qualitative Feedback on Agency Service Delivery. Abstract...

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2010-09-22

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Flight Engineers and Flight Navigators AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice and request... information collection. Information collected is used to determine certification eligibility of Flight...

78 FR 22022 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-12

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Airport Noise... respondents are those airport operators voluntarily submitting noise exposure maps and noise compatibility....gov . SUPPLEMENTARY INFORMATION: OMB Control Number: 2120-0517. Title: Airport Noise Compatibility...

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Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-27

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: ACSEP Evaluation... information collection. The Federal Register Notice with a 60-day comment period soliciting comments on the...

Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET.

PubMed

de Leon, Mony J; Li, Yi; Okamura, Nobuyuki; Tsui, Wai H; Saint-Louis, Les A; Glodzik, Lidia; Osorio, Ricardo S; Fortea, Juan; Butler, Tracy; Pirraglia, Elizabeth; Fossati, Silvia; Kim, Hee-Jin; Carare, Roxana O; Nedergaard, Maiken; Benveniste, Helene; Rusinek, Henry

2017-09-01

Evidence supporting the hypothesis that reduced cerebrospinal fluid (CSF) clearance is involved in the pathophysiology of Alzheimer disease (AD) comes primarily from rodent models. However, unlike rodents, in which predominant extracranial CSF egress is via olfactory nerves traversing the cribriform plate, human CSF clearance pathways are not well characterized. Dynamic PET with 18 F-THK5117, a tracer for tau pathology, was used to estimate the ventricular CSF time-activity as a biomarker for CSF clearance. We tested 3 hypotheses: extracranial CSF is detected at the superior turbinates; CSF clearance is reduced in AD; and CSF clearance is inversely associated with amyloid deposition. Methods: Fifteen subjects, 8 with AD and 7 normal control volunteers, were examined with 18 F-THK5117. Ten subjects additionally underwent 11 C-Pittsburgh compound B ( 11 C-PiB) PET scanning, and 8 were 11 C-PiB-positive. Ventricular time-activity curves of 18 F-THK5117 were used to identify highly correlated time-activity curves from extracranial voxels. Results: For all subjects, the greatest density of CSF-positive extracranial voxels was in the nasal turbinates. Tracer concentration analyses validated the superior nasal turbinate CSF signal intensity. AD patients showed ventricular tracer clearance reduced by 23% and 66% fewer superior turbinate CSF egress sites. Ventricular CSF clearance was inversely associated with amyloid deposition. Conclusion: The human nasal turbinate is part of the CSF clearance system. Lateral ventricle and superior nasal turbinate CSF clearance abnormalities are found in AD. Ventricular CSF clearance reductions are associated with increased brain amyloid depositions. These data suggest that PET-measured CSF clearance is a biomarker of potential interest in AD and other neurodegenerative diseases. © 2017 by the Society of Nuclear Medicine and Molecular Imaging.

Cellular functions of TIP60.

PubMed

Sapountzi, Vasileia; Logan, Ian R; Robson, Craig N

2006-01-01

TIP60 was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. As a consequence, the role of TIP60 in transcriptional regulation has been investigated intensively. Recent data suggest that TIP60 has more divergent functions than originally thought and roles for TIP60 in many processes, such as cellular signalling, DNA damage repair, cell cycle and checkpoint control and apoptosis are emerging. TIP60 is a tightly regulated transcriptional coregulator, acting in a large multiprotein complex for a range of transcription factors including androgen receptor, Myc, STAT3, NF-kappaB, E2F1 and p53. This usually involves recruitment of TIP60 acetyltransferase activities to chromatin. Additionally, in response to DNA double strand breaks, TIP60 is recruited to DNA lesions where it participates both in the initial as well as the final stages of repair. Here, we describe how TIP60 is a multifunctional enzyme involved in multiple nuclear transactions.

Dual clearance squeeze film damper

NASA Technical Reports Server (NTRS)

Fleming, D. P. (Inventor)

1985-01-01

A dual clearance hydrodynamic liquid squeeze film damper for a gas turbine engine is described. Under normal operating conditions, the device functions as a conventional squeeze film damper, using only one of its oil films. When an unbalance reaches abusive levels, as may occur with a blade loss or foreign object damage, a second, larger clearance film becomes active, controlling vibration amplitudes in a near optimum manner until the engine can be safely shut down and repaired.

78 FR 40262 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Aircraft Noise.... 76, page 23628. This collection ensures that U.S. operators have proper noise certification...: 2120-0737. Title: Aircraft Noise Certification Documents for International Operations. Form Numbers...

76 FR 47287 - Agency Information Collection Activities: Requests for Comments; Clearance of a New Information...

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2011-08-04

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76 FR 4743 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection(s): NAS Data... information collection. The Federal Register Notice with a 60-day comment period soliciting comments on the...

77 FR 47491 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-08

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Flight Simulation... simulation training. DATES: Written comments should be submitted by September 7, 2012. FOR FURTHER... INFORMATION: OMB Control Number: 2120-0680. Title: Flight Simulation Device Initial and Continuing...

76 FR 20804 - Agency Information Collection Activities: Requests for Comments; Clearance of a Renewed Approval...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... DEPARTMENT OF TRANSPORTATION Office of the Secretary [Docket No. DOT-OST-2011-0057] Agency Information Collection Activities: Requests for Comments; Clearance of a Renewed Approval of Information Collection(s): Procedures for Transportation Workplace Drug and Alcohol Testing Programs AGENCY: Office of...

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Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-09

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Advanced... about our intention to request the Office of Management and Budget (OMB) approval to renew an information collection. The Advanced Qualification Program (AQP) incorporates data driven quality control...

78 FR 75670 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-12

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Advanced... about our intention to request the Office of Management and Budget (OMB) approval to renew an information collection. The Advanced Qualification Program uses data driven quality control processes for...

78 FR 23628 - Agency Information Collection Activities; Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-19

... Activities; Requests for Comments; Clearance of Renewed Approval of Information Collection: Aircraft Noise... to renew an information collection. This collection ensures that U.S. operators have proper noise...: OMB Control Number: 2120-073. Title: Aircraft Noise Certification Documents for International...

76 FR 30421 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-25

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Airport Noise... 13266. The respondents are those airport operators voluntarily submitting noise exposure maps and noise[email protected] . SUPPLEMENTARY INFORMATION: OMB Control Number: 2120-0517. Title: Airport Noise...

75 FR 52803 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-27

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Maintenance, Preventative Maintenance, Rebuilding and Alteration AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... invites public comments about our intention to request the Office of Management and Budget (OMB) approval...

77 FR 60166 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-02

...: 2120-0018. Title: Certification Procedures for Products and Parts. Form Numbers: FAA Forms 8110-12... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Certification Procedures for Products and Parts AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice and...

System-Level Design of a Shape Memory Alloy Actuator for Active Clearance Control in the High-Pressure Turbine

NASA Technical Reports Server (NTRS)

DeCastro, Jonathan A.; Melcher, Kevin J.; Noebe, Ronald D.

2005-01-01

This paper describes results of a numerical analysis evaluating the feasibility of high-temperature shape memory alloys (HTSMA) for active clearance control actuation in the high-pressure turbine section of a modern turbofan engine. The prototype actuator concept considered here consists of parallel HTSMA wires attached to the shroud that is located on the exterior of the turbine case. A transient model of an HTSMA actuator was used to evaluate active clearance control at various operating points in a test bed aircraft engine simulation. For the engine under consideration, each actuator must be designed to counteract loads from 380 to 2000 lbf and displace at least 0.033 inches. Design results show that an actuator comprised of 10 wires 2 inches in length is adequate for control at critical engine operating points and still exhibits acceptable failsafe operability and cycle life. A proportional-integral-derivative (PID) controller with integrator windup protection was implemented to control clearance amidst engine transients during a normal mission. Simulation results show that the control system exhibits minimal variability in clearance control performance across the operating envelope. The final actuator design is sufficiently small to fit within the limited space outside the high-pressure turbine case and is shown to consume only small amounts of bleed air to adequately regulate temperature.

Creatinine clearance test

MedlinePlus

Serum creatinine clearance; Kidney function - creatinine clearance; Renal function - creatinine clearance ... the body entirely by the kidneys. If kidney function is abnormal, creatinine level increases in the blood ...

77 FR 29748 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-18

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Flight Simulation... obtained and maintained by those who conduct flight simulation training. DATES: Written comments should be... Simulation Device Initial and Continuing Qualification and Use. Form Numbers: There are no FAA forms...

78 FR 38794 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-27

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Competition Plans... that a covered airport submit a written competition plan to the Secretary/Administrator in order to... INFORMATION: OMB Control Number: 2120-0661. Title: Competition Plans, Passenger Facility Charges. Form Numbers...

76 FR 53528 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-26

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Advanced... about our intention to request the Office of Management and Budget (OMB) approval for to renew an... Advanced Qualification Program (AQP) incorporates data driven quality control processes for validating and...

78 FR 5857 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-28

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Airport Noise... information collection. The respondents are those airport operators voluntarily submitting noise exposure maps and noise compatibility programs to the FAA for review and approval. DATES: Written comments should be...

76 FR 81008 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-27

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Training and..., 2011, vol. 76, no. 207, page 66349. The rule allows some experienced pilots who would otherwise qualify...: 2120-0600 . Title: Training and Qualification Requirements for Check Airmen and Flight Instructors...

77 FR 36330 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-18

... certificates and associated ratings. Pilot schools train private, commercial, flight instructor, and airline transport pilots, along with training for associated ratings in various types of aircraft. The form is also... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Pilot Schools...

78 FR 5858 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-28

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Operations... intention to request the Office of Management and Budget (OMB) approval for to renew an information collection. The FAA assesses the information collected and issues operations specifications to foreign air...

78 FR 5856 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-28

... Title: Certification Procedures for Products and Parts Form Numbers: FAA Forms 8110-12, 8130-1, 8130-6... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Certification Procedures for Products and Parts AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice and...

75 FR 59320 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-27

... Number: 2120-0018. Title: Certification Procedures for Products and Parts. Form Numbers: FAA Forms 8110... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection(s): Certification Procedures for Products and Parts AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice and...

Renal Clearance: Using an Interactive Activity to Visualize a Tricky Concept

ERIC Educational Resources Information Center

Hull, Kerry

2016-01-01

Renal clearance, the volume of blood cleared of a substance in a particular time period, is commonly recognized as one of the most difficult concepts in physiology. This difficulty may in part reflect the quantitative nature of renal clearance since many life sciences majors perceive that mathematics is irrelevant to their discipline. Students may…

77 FR 20093 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-03

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Pilot Schools... information on FAA Form 8420-8, Application for Pilot School Certificates, is required from applicants who wish to be issued pilot school certificates and associated ratings. DATES: Written comments should be...

75 FR 72858 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-26

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: High Density... records of slot transfers at High Density Traffic Airports. The information is provided by air carriers and commuter operators, or other persons holding a slot at High Density Airports. DATES: Written...

75 FR 52802 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-27

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: High Density... maintain accurate records of slot transfers at High Density Traffic Airports. The information is provided by air carriers and commuter operators, or other persons holding a slot at High Density Airports...

76 FR 36167 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-21

... INFORMATION: OMB Control Number: 2120-0042. Title: Aircraft Registration. Form Numbers: FAA Forms 8050-1, 8050.../or revocation of registration. The information collected is used by the FAA to register an aircraft... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Aircraft...

76 FR 74840 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-01

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Notice of Landing... following collection of information was published on September 23, 2011, vol. 76, no. 185, pages 59185-59186. FAA Form 7480-1 (Notice of Landing Area Proposal) is used to collect information about any...

78 FR 22021 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-12

..., page 71473. FAA Form 7480-1 (Notice of Landing Area Proposal) is used to collect information about any... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Notice of Landing... information collection. The Federal Register Notice with a 60-day comment period soliciting [[Page 22022...

Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice

PubMed Central

He, Xiao-fei; Liu, Dong-xu; Zhang, Qun; Liang, Feng-ying; Dai, Guang-yan; Zeng, Jin-sheng; Pei, Zhong; Xu, Guang-qing; Lan, Yue

2017-01-01

Age is characterized by chronic inflammation, leading to synaptic dysfunction and dementia because the clearance of protein waste is reduced. The clearance of proteins depends partly on the permeation of the blood–brain barrier (BBB) or on the exchange of water and soluble contents between the cerebrospinal fluid (CSF) and the interstitial fluid (ISF). A wealth of evidence indicates that physical exercise improves memory and cognition in neurodegenerative diseases during aging, such as Alzheimer’s disease (AD), but the influence of physical training on glymphatic clearance, BBB permeability and neuroinflammation remains unclear. In this study, glymphatic clearance and BBB permeability were evaluated in aged mice using in vivo two-photon imaging. The mice performed voluntary wheel running exercise and their water-maze cognition was assessed; the expression of the astrocytic water channel aquaporin 4 (AQP4), astrocyte and microglial activation, and the accumulation of amyloid beta (Aβ) were evaluated with immunofluorescence or an enzyme-linked immunosorbent assay (ELISA); synaptic function was investigated with Thy1–green fluorescent protein (GFP) transgenic mice and immunofluorescent staining. Voluntary wheel running significantly improved water-maze cognition in the aged mice, accelerated the efficiency of glymphatic clearance, but which did not affect BBB permeability. The numbers of activated astrocytes and microglia decreased, AQP4 expression increased, and the distribution of astrocytic AQP4 was rearranged. Aβ accumulation decreased, whereas dendrites, dendritic spines and postsynaptic density protein (PSD95) increased. Our study suggests that voluntary wheel running accelerated glymphatic clearance but not BBB permeation, improved astrocytic AQP4 expression and polarization, attenuated the accumulation of amyloid plaques and neuroinflammation, and ultimately protected mice against synaptic dysfunction and a decline in spatial cognition. These data

76 FR 59185 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-23

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Notice of Landing... information collection. FAA Form 7480-1 (Notice of Landing Area Proposal) is used to collect information about.... Title: Notice of Landing Area Proposal. Form Numbers: FAA Form 7480-1. Type of Review: Renewal of an...

77 FR 71473 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-30

... Activities: Requests for Comments; Clearance of Renewed Approval of Information Collection: Notice of Landing... information collection. FAA Form 7480-1 (Notice of Landing Area Proposal) is used to collect information about.... Title: Notice of Landing Area Proposal. Form Numbers: FAA Form 7480-1. Type of Review: Renewal of an...

Impairment of Release Site Clearance within the Active Zone by Reduced SCAMP5 Expression Causes Short-Term Depression of Synaptic Release.

PubMed

Park, Daehun; Lee, Unghwi; Cho, Eunji; Zhao, Haiyan; Kim, Jung Ah; Lee, Byoung Ju; Regan, Philip; Ho, Won-Kyung; Cho, Kwangwook; Chang, Sunghoe

2018-03-20

Despite being a highly enriched synaptic vesicle (SV) protein and a candidate gene for autism, the physiological function of SCAMP5 remains mostly enigmatic. Here, using optical imaging and electrophysiological experiments, we demonstrate that SCAMP5 plays a critical role in release site clearance at the active zone. Truncation analysis revealed that the 2/3 loop domain of SCAMP5 directly interacts with adaptor protein 2, and this interaction is critical for its role in release site clearance. Knockdown (KD) of SCAMP5 exhibited pronounced synaptic depression accompanied by a slower recovery of the SV pool. Moreover, it induced a strong frequency-dependent short-term depression of synaptic release, even under the condition of sufficient release-ready SVs. Super-resolution microscopy further proved the defects in SV protein clearance induced by KD. Thus, reduced expression of SCAMP5 may impair the efficiency of SV clearance at the active zone, and this might relate to the synaptic dysfunction observed in autism. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Accurate real-time sensing tip for aqueous NO with optical fibers embedded in active hydrogel waveguide

NASA Astrophysics Data System (ADS)

Chung, Chieh-Wen; Tsai, May-Jywan; Lin, Peng-Wei; Huang, Ding-Wen; Wang, Kuan-Hsun; Chen, Yu-An; Meng, Hsin-Fei; Zan, Hsiao-Wen; Cheng, Henrich; Tong, Limin; Zhang, Lei; Horng, Sheng-Fu; Hung, Cheng-Hsiung

2018-02-01

A NO sensing tip is made by inserting two parallel optical fibers inside a poly 2-hydroxyethyl methacrylate (PolyHEMA) hydrogel waveguide mixed with the probe molecule 1, 2-Diaminoanthraquinone (DAQ). There is a length difference of 1 mm between the two fibers, and the light has to propagate through the difference from the short fiber to the long fiber. The total cross section area of the active hydrogel waveguide embedded with the fibers is only 3mm x 1.2 mm. For practical use the tip is housed in a needle for mechanical protection and the sensing tip is able to detect aqueous NO concentration around 1 μM with time resolution about 5 minutes. Such a sensing tip can be used to monitor the medical conditions inside the brain after a stroke or a brain injury.

Constitutive androstane receptor activation promotes bilirubin clearance in a murine model of alcoholic liver disease.

PubMed

Wang, Xiuyan; Zheng, Liyu; Wu, Jinming; Tang, Binbin; Zhang, Mengqin; Zhu, Debin; Lin, Xianfan

2017-06-01

Increased plasma levels of bilirubin have been reported in rat models and patients with alcoholic liver disease (ALD). The constitutive androstane receptor (CAR) is a known xenobiotic receptor, which induces the detoxification and transport of bilirubin. In the present study, the bilirubin transport regulatory mechanisms, and the role of CAR activation in hepatic and extrahepatic bilirubin clearance were investigated in a murine model of ALD. The mice were fed a Lieber-DeCarli ethanol diet or an isocaloric control diet for 4 weeks, followed by the administration of CAR agonists, 1,4-bis-[2‑(3,5-dichlorpyridyloxy)]benzene (TCPOBOP) and phenobarbital (PB), and their vehicles to examine the effect of the pharmacological activation of CAR on serum levels of bilirubin and on the bilirubin clearance pathway in ALD by serological survey, western blotting and reverse transcription‑quantitative polymerase chain reaction. The results showed that chronic ethanol ingestion impaired the nuclear translocation of CAR, which was accompanied by elevated serum levels of bilirubin, suppression of the expression of hepatic and renal organic anion transporting polypeptide (OATP) 1A1 and hepatic multidrug resistance‑associated protein 2 (MRP2), and induction of the expression of UDP-glucuronosyltransferase (UGT) 1A1. The activation of CAR by TCPOBOP and PB resulted in downregulation of the serum levels of bilirubin followed by selective upregulation of the expression levels of OATP1A1, OATP1A4, UGT1A1 and MRP2 in ALD. These results revealed the bilirubin transport regulatory mechanisms and highlighted the importance of CAR in modulating the bilirubin clearance pathway in the ALD mouse model.

Comparison of Two Alternate Methods for Tracking Toe Clearance

NASA Technical Reports Server (NTRS)

Miller, Christopher A.; Feiveson, Alan H.; Bloomberg, Jacob J.

2007-01-01

Analyses of toe clearance during the swing phase of locomotion has often been utilized in determining a subject s propensity to trip while either walking or stepping over an obstacle. In the literature, toe clearance has been studied using a marker on the superior aspect of the second toe (rtoe), a marker on the lateral aspect of the fifth metatarsal head (mth5), or a virtual marker positioned at the anterior tip of the toe (vtoe). The purpose of this study was to compute toe clearance and associated parameters using a fifth metatarsal marker and a virtual toe marker, and compare the results with those of the standard toe marker. Subjects walked on a motorized treadmill at five different speeds while performing a visual acuity task at two separate target distances (ten 60-second trials). The minimum vertical height (TCl) was determined for each stride, along with its point of occurence in the gait cycle, and the angles of the foot and ankle at that time. A regression analysis was performed on the vtoe and mth5 results versus rtoe individually. For all TCl parameters, the mth5 marker did not correlate well with rtoe; the vtoe marker showed better agreement. Most importantly, the mth5 marker predicted a later occurence of TCl than rtoe and vtoe - thereby missing the most dangerous point in swing phase for a trip. From this analysis, the vtoe marker proved to be a better analog to rtoe than mth5, especially for determining a subject s propensity to trip.

Structure-activity models of oral clearance, cytotoxicity, and LD50: a screen for promising anticancer compounds

PubMed Central

Boik, John C; Newman, Robert A

2008-01-01

Background Quantitative structure-activity relationship (QSAR) models have become popular tools to help identify promising lead compounds in anticancer drug development. Few QSAR studies have investigated multitask learning, however. Multitask learning is an approach that allows distinct but related data sets to be used in training. In this paper, a suite of three QSAR models is developed to identify compounds that are likely to (a) exhibit cytotoxic behavior against cancer cells, (b) exhibit high rat LD50 values (low systemic toxicity), and (c) exhibit low to modest human oral clearance (favorable pharmacokinetic characteristics). Models were constructed using Kernel Multitask Latent Analysis (KMLA), an approach that can effectively handle a large number of correlated data features, nonlinear relationships between features and responses, and multitask learning. Multitask learning is particularly useful when the number of available training records is small relative to the number of features, as was the case with the oral clearance data. Results Multitask learning modestly but significantly improved the classification precision for the oral clearance model. For the cytotoxicity model, which was constructed using a large number of records, multitask learning did not affect precision but did reduce computation time. The models developed here were used to predict activities for 115,000 natural compounds. Hundreds of natural compounds, particularly in the anthraquinone and flavonoids groups, were predicted to be cytotoxic, have high LD50 values, and have low to moderate oral clearance. Conclusion Multitask learning can be useful in some QSAR models. A suite of QSAR models was constructed and used to screen a large drug library for compounds likely to be cytotoxic to multiple cancer cell lines in vitro, have low systemic toxicity in rats, and have favorable pharmacokinetic properties in humans. PMID:18554402

Structure-activity models of oral clearance, cytotoxicity, and LD50: a screen for promising anticancer compounds.

PubMed

Boik, John C; Newman, Robert A

2008-06-13

Quantitative structure-activity relationship (QSAR) models have become popular tools to help identify promising lead compounds in anticancer drug development. Few QSAR studies have investigated multitask learning, however. Multitask learning is an approach that allows distinct but related data sets to be used in training. In this paper, a suite of three QSAR models is developed to identify compounds that are likely to (a) exhibit cytotoxic behavior against cancer cells, (b) exhibit high rat LD50 values (low systemic toxicity), and (c) exhibit low to modest human oral clearance (favorable pharmacokinetic characteristics). Models were constructed using Kernel Multitask Latent Analysis (KMLA), an approach that can effectively handle a large number of correlated data features, nonlinear relationships between features and responses, and multitask learning. Multitask learning is particularly useful when the number of available training records is small relative to the number of features, as was the case with the oral clearance data. Multitask learning modestly but significantly improved the classification precision for the oral clearance model. For the cytotoxicity model, which was constructed using a large number of records, multitask learning did not affect precision but did reduce computation time. The models developed here were used to predict activities for 115,000 natural compounds. Hundreds of natural compounds, particularly in the anthraquinone and flavonoids groups, were predicted to be cytotoxic, have high LD50 values, and have low to moderate oral clearance. Multitask learning can be useful in some QSAR models. A suite of QSAR models was constructed and used to screen a large drug library for compounds likely to be cytotoxic to multiple cancer cell lines in vitro, have low systemic toxicity in rats, and have favorable pharmacokinetic properties in humans.

77 FR 37706 - Agency Information Collection Activities: 30-Day Notice of Intention To Request Clearance of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-22

... purchase price is attributable either directly or indirectly to such assets, the transaction may not be... DEPARTMENT OF THE INTERIOR National Park Service [NPS-BSD-CONC-10370; 2410-OYC] Agency Information Collection Activities: 30-Day Notice of Intention To Request Clearance of Collection of Information...

The CF6 Jet Engine Performance Improvement - Low Pressure Turbine Active Clearance Control

NASA Technical Reports Server (NTRS)

Beck, B. D.; Fasching, W. A.

1982-01-01

A low pressure turbine (LPT) active clearance control (ACC) cooling system was developed to reduce the fuel consumption of current CF6-50 turbofan engines for wide bodied commercial aircraft. The program performance improvement goal of 0.3% delta sfc was determined to be achievable with an improved impingement cooling system. The technology enables the design of an optimized manifold and piping system which is capable of a performance gain of 0.45% delta sfc.

Tip off the HAT– Epigenetic control of learning and memory by Drosophila Tip60

PubMed Central

Xu, Songjun; Elefant, Felice

2015-01-01

Disruption of epigenetic gene control mechanisms involving histone acetylation in the brain causes cognitive impairment, a debilitating hallmark of most neurodegenerative disorders. Histone acetylation regulates cognitive gene expression via chromatin packaging control in neurons. Unfortunately, the histone acetyltransferases (HATs) that generate such neural epigenetic signatures and their mechanisms of action remain unclear. Our recent findings provide insight into this question by demonstrating that Tip60 HAT action is critical for morphology and function of the mushroom body (MB), the learning and memory center in the Drosophila brain. We show that Tip60 is robustly produced in MB Kenyon cells and extending axonal lobes and that targeted MB Tip60 HAT loss results in axonal outgrowth disruption. Functional consequences of loss and gain of Tip60 HAT levels in the MB are evidenced by defects in memory. Tip60 ChIP-Seq analysis reveals enrichment for genes that function in cognitive processes and accordingly, key genes representing these pathways are misregulated in the Tip60 HAT mutant fly brain. Remarkably, increasing levels of Tip60 in the MB rescues learning and memory deficits resulting from Alzheimer's disease associated amyloid precursor protein (APP) induced neurodegeneration. Our studies highlight the potential of HAT activators as a therapeutic option for cognitive disorders. PMID:26327426

A model of clearance rate regulation in mussels

NASA Astrophysics Data System (ADS)

Fréchette, Marcel

2012-10-01

Clearance rate regulation has been modelled as an instantaneous response to food availability, independent of the internal state of the animals. This view is incompatible with latent effects during ontogeny and phenotypic flexibility in clearance rate. Internal-state regulation of clearance rate is required to account for these patterns. Here I develop a model of internal-state based regulation of clearance rate. External factors such as suspended sediments are included in the model. To assess the relative merits of instantaneous regulation and internal-state regulation, I modelled blue mussel clearance rate and growth using a DEB model. In the usual standard feeding module, feeding is governed by a Holling's Type II response to food concentration. In the internal-state feeding module, gill ciliary activity and thus clearance rate are driven by internal reserve level. Factors such as suspended sediments were not included in the simulations. The two feeding modules were compared on the basis of their ability to capture the impact of latent effects, of environmental heterogeneity in food abundance and of physiological flexibility on clearance rate and individual growth. The Holling feeding module was unable to capture the effect of any of these sources of variability. In contrast, the internal-state feeding module did so without any modification or ad hoc calibration. Latent effects, however, appeared transient. With simple annual variability in temperature and food concentration, the relationship between clearance rate and food availability predicted by the internal-state feeding module was quite similar to that observed in Norwegian fjords. I conclude that in contrast with the usual Holling feeding module, internal-state regulation of clearance rate is consistent with well-documented growth and clearance rate patterns.

Predicting Human Clearance of OATP substrates using Cynomolgus monkey: In vitro-in vivo scaling of hepatic uptake clearance.

PubMed

de Bruyn, Tom; Ufuk, Ayse; Cantrill, Carina; Kosa, Rachel E; Bi, Yi-An; Niosi, Mark; Modi, Sweta; Rodrigues, A David; Tremaine, Larry M; Varma, Manthena Vs; Galetin, Aleksandra; Houston, J Brian

2018-05-02

This work explores the utility of the cynomolgus monkey as a preclinical model to predict hepatic uptake clearance mediated by organic anion transporting polypeptide (OATP) transporters. Nine OATP substrates (rosuvastatin, pravastatin, repaglinide, fexofenadine, cerivastatin, telmisartan, pitavastatin, bosentan and valsartan) were investigated in plated cynomolgus monkey and human hepatocytes. Total uptake clearance and passive diffusion were measured in vitro from initial rates in the absence and presence of the OATP inhibitor rifamycin SV, respectively. Total uptake clearance values in plated hepatocytes ranged over three orders of magnitude in both species with a similar rank order and good agreement in the relative contribution of active transport to total uptake between cynomolgus monkey and human. In vivo hepatic clearance for these nine drugs was determined in cynomolgus monkey after intravenous dosing. Hepatic clearances showed a similar range to human parameters and good predictions from respective hepatocyte parameters (with 2.7 and 3.8-fold bias on average, respectively). The use of cross species empirical scaling factors (based on either dataset average or individual drug scaling factor from cynomolgus monkey data) improved prediction (less bias, better concordance) of human hepatic clearance from human hepatocyte data alone. In vitro intracellular binding in hepatocytes also correlated well between species. It is concluded that the minimal species differences observed for the current dataset between cynomolgus monkey and human hepatocyte uptake, both in vitro and in vivo, support future use of this preclinical model to delineate drug hepatic uptake and enable prediction of human in vivo intrinsic hepatic clearance. The American Society for Pharmacology and Experimental Therapeutics.

76 FR 35069 - Agency Information Collection Activities; Proposed Collection; Comment Request; Generic Clearance...

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The sensitivity and negative predictive value of a pediatric cervical spine clearance algorithm that minimizes computerized tomography.

PubMed

Arbuthnot, Mary; Mooney, David P

2017-01-01

It is crucial to identify cervical spine injuries while minimizing ionizing radiation. This study analyzes the sensitivity and negative predictive value of a pediatric cervical spine clearance algorithm. We performed a retrospective review of all children <21years old who were admitted following blunt trauma and underwent cervical spine clearance utilizing our institution's cervical spine clearance algorithm over a 10-year period. Age, gender, International Classification of Diseases 9th Edition diagnosis codes, presence or absence of cervical collar on arrival, Injury Severity Score, and type of cervical spine imaging obtained were extracted from the trauma registry and electronic medical record. Descriptive statistics were used and the sensitivity and negative predictive value of the algorithm were calculated. Approximately 125,000 children were evaluated in the Emergency Department and 11,331 were admitted. Of the admitted children, 1023 patients arrived in a cervical collar without advanced cervical spine imaging and were evaluated using the cervical spine clearance algorithm. Algorithm sensitivity was 94.4% and the negative predictive value was 99.9%. There was one missed injury, a spinous process tip fracture in a teenager maintained in a collar. Our algorithm was associated with a low missed injury rate and low CT utilization rate, even in children <3years old. IV. Published by Elsevier Inc.

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Evaluation of degree of conversion and hardness of dental composites photo-activated with different light guide tips.

PubMed

Galvão, Marília Regalado; Caldas, Sergei Godeiro Fernandes Rabelo; Bagnato, Vanderlei Salvador; de Souza Rastelli, Alessandra Nara; de Andrade, Marcelo Ferrarezi

2013-01-01

The aim of this study was to evaluate the degree of conversion and hardness of different composite resins, photo-activated for 40 s with two different light guide tips, fiber optic and polymer. Five specimens were made for each group evaluated. The percentage of unreacted carbon double bonds (% C═C) was determined from the ratio of absorbance intensities of aliphatic C═C (peak at 1637 cm(-1)) against internal standard before and after curing of the specimen: aromatic C-C (peak at 1610 cm(-1)). The Vickers hardness measurements were performed in a universal testing machine. A 50 gf load was used and the indenter with a dwell time of 30 seconds. The degree of conversion and hardness mean values were analyzed separately by ANOVA and Tukey's test, with a significance level set at 5%. The mean values of degree of conversion for the polymer and fiber optic light guide tip were statistically different (P<.001). The hardness mean values were statistically different among the light guide tips (P<.001), but also there was difference between top and bottom surfaces (P<.001). The results showed that the resins photo-activated with the fiber optic light guide tip promoted higher values for degree of conversion and hardness.

Evaluation of degree of conversion and hardness of dental composites photo-activated with different light guide tips

PubMed Central

Galvão, Marília Regalado; Caldas, Sergei Godeiro Fernandes Rabelo; Bagnato, Vanderlei Salvador; de Souza Rastelli, Alessandra Nara; de Andrade, Marcelo Ferrarezi

2013-01-01

Objective: The aim of this study was to evaluate the degree of conversion and hardness of different composite resins, photo-activated for 40 s with two different light guide tips, fiber optic and polymer. Methods: Five specimens were made for each group evaluated. The percentage of unreacted carbon double bonds (% C═C) was determined from the ratio of absorbance intensities of aliphatic C═C (peak at 1637 cm−1) against internal standard before and after curing of the specimen: aromatic C-C (peak at 1610 cm−1). The Vickers hardness measurements were performed in a universal testing machine. A 50 gf load was used and the indenter with a dwell time of 30 seconds. The degree of conversion and hardness mean values were analyzed separately by ANOVA and Tukey’s test, with a significance level set at 5%. Results: The mean values of degree of conversion for the polymer and fiber optic light guide tip were statistically different (P<.001). The hardness mean values were statistically different among the light guide tips (P<.001), but also there was difference between top and bottom surfaces (P<.001). Conclusions: The results showed that the resins photo-activated with the fiber optic light guide tip promoted higher values for degree of conversion and hardness. PMID:23407620

Site clearance working group

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The Gulf of Mexico and Louisiana continue to be areas with a high level of facility removal, and the pace of removal is projected to increase. Regulations were promulgated for the Gulf of Mexico and Louisiana requiring that abandoned sites be cleared of debris that could interfere with fishing and shrimping activities. The site clearance regulations also required verification that the sites were clear. Additionally, government programs were established to compensate fishermen for losses associated with snagging their equipment on oil and gas related objects that remained on the water bottoms in areas other than active producing sites and sitesmore » that had been verified as clear of obstructions and snags. The oil and gas industry funds the compensation programs. This paper reviews the regulations and evolving operating practices in the Gulf of Mexico and Louisiana where site clearance and fisherman`s gear compensation regulations have been in place for a number of years. Although regulations and guidelines may be in place elsewhere in the world, this paper focuses on the Gulf of Mexico and Louisiana. Workshop participants are encouraged to bring up international issues during the course of the workshop. Additionally, this paper raises questions and focuses on issues that are of concern to the various Gulf of Mexico and Louisiana water surface and water bottom stakeholders. This paper does not have answers to the questions or issues. During the workshop participants will debate the questions and issues in an attempt to develop consensus opinions and/or make suggestions that can be provided to the appropriate organizations, both private and government, for possible future research or policy adjustments. Site clearance and facility removal are different activities. Facility removal deals with removal of the structures used to produce oil and gas including platforms, wells, casing, piles, pipelines, well protection structures, etc.« less

20 CFR 655.150 - Interstate clearance of job order.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Interstate clearance of job order. 655.150... job order. (a) SWA posts in interstate clearance system. The SWA must promptly place the job order in... transmit a copy of its active job order to all States listed in the job order as anticipated worksites...

20 CFR 655.150 - Interstate clearance of job order.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 3 2013-04-01 2013-04-01 false Interstate clearance of job order. 655.150... job order. (a) SWA posts in interstate clearance system. The SWA must promptly place the job order in... transmit a copy of its active job order to all States listed in the job order as anticipated worksites...

20 CFR 655.150 - Interstate clearance of job order.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Interstate clearance of job order. 655.150... job order. (a) SWA posts in interstate clearance system. The SWA must promptly place the job order in... transmit a copy of its active job order to all States listed in the job order as anticipated worksites...

20 CFR 655.150 - Interstate clearance of job order.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Interstate clearance of job order. 655.150... job order. (a) SWA posts in interstate clearance system. The SWA must promptly place the job order in... transmit a copy of its active job order to all States listed in the job order as anticipated worksites...

20 CFR 655.150 - Interstate clearance of job order.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 3 2014-04-01 2014-04-01 false Interstate clearance of job order. 655.150... job order. (a) SWA posts in interstate clearance system. The SWA must promptly place the job order in... transmit a copy of its active job order to all States listed in the job order as anticipated worksites...

Cold-air performance of a tip turbine designed to drive a lift fan

NASA Technical Reports Server (NTRS)

Haas, J. E.; Kofskey, M. G.; Hotz, G. M.

1978-01-01

Performance was obtained over a range of speeds and pressure ratios for a 0.4 linear scale version of the LF460 lift fan turbine with the rotor radial tip clearance reduced to about 2.5 percent of the rotor blade height. These tests covered a range of speeds from 60 to 140 percent of design equivalent speed and a range of scroll inlet total to diffuser exit static pressure ratios from 2.6 to 4.2. Results are presented in terms of equivalent mass flow, equivalent torque, equivalent specific work, and efficiency.

Measurements of the tip leakage vortex structures and turbulence in the meridional plane of an axial water-jet pump

NASA Astrophysics Data System (ADS)

Wu, Huixuan; Miorini, Rinaldo L.; Katz, Joseph

2011-04-01

Particle image velocimetry (PIV) measurements at varying resolutions focus on the flow structures in the tip region of a water-jet pump rotor, including the tip-clearance flow and the rollup process of a tip leakage vortex (TLV). Unobstructed views of these regions are facilitated by matching the optical refractive index of the transparent pump with that of the fluid. High-magnification data reveal the flow non-uniformities and associated turbulence within the tip gap. Instantaneous data and statistics of spatial distributions and strength of vortices in the rotor passage reveal that the leakage flow emerges as a wall jet with a shear layer containing a train of vortex filaments extending from the tip of the blade. These vortices are entrained into the TLV, but do not have time to merge. TLV breakdown in the aft part of the blade passage further fragments these structures, increasing their number and reducing their size. Analogy is made between the circumferential development of the TLV in the blade passage and that of the starting jet vortex ring rollup. Subject to several assumptions, these flows display similar trends, including conditions for TLV separation from the shear layer feeding vorticity into it.

Analysis of foot clearance in firefighters during ascent and descent of stairs.

PubMed

Kesler, Richard M; Horn, Gavin P; Rosengren, Karl S; Hsiao-Wecksler, Elizabeth T

2016-01-01

Slips, trips, and falls are a leading cause of injury to firefighters with many injuries occurring while traversing stairs, possibly exaggerated by acute fatigue from firefighting activities and/or asymmetric load carriage. This study examined the effects that fatigue, induced by simulated firefighting activities, and hose load carriage have on foot clearance while traversing stairs. Landing and passing foot clearances for each stair during ascent and descent of a short staircase were investigated. Clearances decreased significantly (p < 0.05) post-exercise for nine of 12 ascent parameters and increased for two of eight descent parameters. Load carriage resulted in significantly decreased (p < 0.05) clearance over three ascent parameters, and one increase during descent. Decreased clearances during ascent caused by fatigue or load carriage may result in an increased trip risk. Increased clearances during descent may suggest use of a compensation strategy to ensure stair clearance or an increased risk of over-stepping during descent. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Adaptive Development

NASA Technical Reports Server (NTRS)

2005-01-01

The goal of this research is to develop and demonstrate innovative adaptive seal technologies that can lead to dramatic improvements in engine performance, life, range, and emissions, and enhance operability for next generation gas turbine engines. This work is concentrated on the development of self-adaptive clearance control systems for gas turbine engines. Researchers have targeted the high-pressure turbine (HPT) blade tip seal location for following reasons: Current active clearance control (ACC) systems (e.g., thermal case-cooling schemes) cannot respond to blade tip clearance changes due to mechanical, thermal, and aerodynamic loads. As such they are prone to wear due to the required tight running clearances during operation. Blade tip seal wear (increased clearances) reduces engine efficiency, performance, and service life. Adaptive sealing technology research has inherent impact on all envisioned 21st century propulsion systems (e.g. distributed vectored, hybrid and electric drive propulsion concepts).

Heat Transfer and Flow on the First Stage Blade Tip of a Power Generation Gas Turbine. Part 1; Experimental Results

NASA Technical Reports Server (NTRS)

Bunker, Ronald S.; Bailey, Jeremy C.; Ameri, Ali A.

1999-01-01

A combined computational and experimental study has been performed to investigate the detailed distribution of convective heat transfer coefficients on the first stage blade tip surface for a geometry typical of large power generation turbines(>100MW). This paper is concerned with the design and execution of the experimental portion of the study. A stationary blade cascade experiment has been run consisting of three airfoils, the center airfoil having a variable tip gap clearance. The airfoil models the aerodynamic tip section of a high pressure turbine blade with inlet Mach number of 0.30, exit Mach number of 0.75, pressure ratio of 1.45, exit Reynolds number based on axial chord of 2.57 x 10(exp 6), and total turning of about 110 degrees. A hue detection based liquid crystal method is used to obtain the detailed heat transfer coefficient distribution on the blade tip surface for flat, smooth tip surfaces with both sharp and rounded edges. The cascade inlet turbulence intensity level took on values of either 5% or 9%. The cascade also models the casing recess in the shroud surface ahead of the blade. Experimental results are shown for the pressure distribution measurements on the airfoil near the tip gap, on the blade tip surface, and on the opposite shroud surface. Tip surface heat transfer coefficient distributions are shown for sharp-edge and rounded-edge tip geometries at each of the inlet turbulence intensity levels.

Visualisation of the flow at the tip of a high speed axial flow turbine rotor: An assessment of flow visualisation techniques and the requirement of the experimental turbine

NASA Astrophysics Data System (ADS)

Bindon, J.; Alder, D.; Ianovici, I.

1987-11-01

The field of flow visualization has been reviewed and its application to the study of the flow near the tip of an unshrouded axial turbine rotor discussed in detail. The logical conceptualization of experiments which could lead to a final understanding of the flow structure was developed and how this leads to test turbine design philosophy is suggested. The rotor periodicity shed by the stator requires that particle of pulse tracing is needed rather than the more universal continuous streamline trace which arises from a continuous tracer injection at a point in a flow. While the whole field of flow visualization at a rotor tip is demanding because of its very nature, pulse tracking will place a greater demand on the development of new skills and techniques. Since streamline tracking is somewhat more standard, these demands will not be as great. A fundamental choice does however need to be made between the two methods. The suggested experimental turbine should thus, always with the facility of infinitely variable Mach number, model the following: (1) Stationary annular cascade with tip clearance inside a stationary outer endwall; (2) Stationary annular cascade with tip clearance inside a moving endwall; (3) The transfer of flow visualization techniques developed into the rotating frame; (4) Fully rotating rotor with no inlet periodicity; (5) Fully rotating rotor with inlet periodicity.

77 FR 32144 - Agency Information Collection Activities: Comment Request; Generic Survey Clearance for the...

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2012-05-31

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Remembering tips

MedlinePlus

Memory aids; Alzheimer disease - remembering tips; Early memory loss - remembering tips; Dementia - remembering tips ... harder for your brain to create a new memory, even while you can remember actions and events ...

Effect of clearance on cartilage tribology in hip hemi-arthroplasty.

PubMed

Lizhang, Jia; Taylor, Simon D; Jin, Zhongmin; Fisher, John; Williams, Sophie

2013-12-01

Hemi-arthroplasty of the hip (an artificial femoral head articulating against the natural acetabulum) is used to treat fractured necks of femur; however, there is evidence that articulation causes erosion of the cartilage, resulting in pain for the patient. Parameters that may influence this cartilage erosion include head material and roughness, clearance between the head and acetabulum and activity levels of the patient. This study has assessed the effect of clearance of hemi-arthroplasty articulations on the contact stress, friction and cartilage deformation in an in vitro tribological simulation of the hemi-arthroplasty joint that applied dynamic loads and motion. It has been demonstrated that peak contact stress increased from 5.6 to 10.6 MPa as radial clearance increased from small (<0.6 mm) to extra-large (>1.8 mm). In all samples, friction factor increased with time and was significantly less with extra-large clearances compared to small (<0.6 mm), medium (0.6-1.2 mm) and large (1.2-1.8 mm) clearances. The cartilage deformation observed was significantly greater in acetabulum samples paired to give small or extra-large clearances compared to those with medium or large clearances.

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Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-09

... precision requirements or power calculations that justify the proposed sample size, the expected response... Clearance for the Collection of Qualitative Feedback on Agency Service Delivery AGENCY: Department of... Collection Request (Generic ICR): ``Generic Clearance for the Collection of Qualitative Feedback on Agency...

Tips for Breastfeeding Moms

MedlinePlus

United States Department of Agriculture Tips for Breastfeeding Moms Making healthy food choices along with regular physical activity will keep you healthy while you breastfeed. Find Your Healthy Eating Style Choose ...

Unsteady Turbine Blade and Tip Heat Transfer Due to Wake Passing

NASA Technical Reports Server (NTRS)

Ameri, Ali A.; Rigby, David L.; Steinthorsson, Erlendur; Heidmann, James; Fabian, John C.

2007-01-01

The geometry and the flow conditions of the first stage turbine blade of GE s E3 engine have been used to obtain the unsteady three-dimensional blade and tip heat transfer. The isothermal wall boundary condition was used. The effect of the upstream wake of the first stage vane was of interest and was simulated by provision of a gust type boundary condition upstream of the blades. A one blade periodic domain was used. The consequence of this choice was explored in a preliminary study which showed little difference in the time mean heat transfer between 1:1 and 2:3 vane/blade domains. The full three-dimensional computations are of the blade having a clearance gap of 2 percent the span. Comparison between the time averaged unsteady and steady heat transfer is provided. It is shown that there is a significant difference between the steady and time mean of unsteady blade heat transfer in localized regions. The differences on the suction side of the blade in the near hub and near tip regions were found to be rather significant. Steady analysis underestimated the blade heat transfer by as much as 20 percent as compared to the time average obtained from the unsteady analysis. As for the blade tip, the steady analysis and the unsteady analysis gave results to within 2 percent.

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2011-03-09

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Development and experimental characterization of a new non contact sensor for blade tip timing

NASA Astrophysics Data System (ADS)

Brouckaert, Jean-Francois; Marsili, Roberto; Rossi, Gianluca; Tomassini, Roberto

2012-06-01

Performances of blade tip timing measurement systems (BTT), recently used for non contact turbine blade vibration measurements, in terms of uncertainty and resolution are strongly affected by sensor characteristics. The sensors used for BTT generate pulses, to be used also for precise measurements of turbine blades time of arrival. All the literature on this measurement techniques do not address this problem in a clear way, defining the relevant dynamic and static sensor characteristics, fundamental for this application. Till now proximity sensors used are based on optical, capacitive, eddy current and microwave measuring principle. Also pressure sensors has been used. In this paper a new sensing principle is proposed. A proximity sensor based on magnetoresistive sensing element has been assembled end tested. A simple and portable test bench with variable speed, blade tip width, variable clearance was built and used in order to characterize the main sensor performances.

Daily heat stress treatment rescues denervation-activated mitochondrial clearance and atrophy in skeletal muscle

PubMed Central

Tamura, Yuki; Kitaoka, Yu; Matsunaga, Yutaka; Hoshino, Daisuke; Hatta, Hideo

2015-01-01

Traumatic nerve injury or motor neuron disease leads to denervation and severe muscle atrophy. Recent evidence indicates that loss of mitochondria and the related reduction in oxidative capacity could be key mediators of skeletal muscle atrophy. As our previous study showed that heat stress increased the numbers of mitochondria in skeletal muscle, we evaluated whether heat stress treatment could have a beneficial impact on denervation-induced loss of mitochondria and subsequent muscle atrophy. Here, we report that daily heat stress treatment (mice placed in a chamber with a hot environment; 40°C, 30 min day−1, for 7 days) rescues the following parameters: (i) muscle atrophy (decreased gastrocnemius muscle mass); (ii) loss of mitochondrial content (decreased levels of ubiquinol–cytochrome c reductase core protein II, cytochrome c oxidase subunits I and IV and voltage-dependent anion channel protein); and (iii) reduction in oxidative capacity (reduced maximal activities of citrate synthase and 3-hydroxyacyl-CoA dehydrogenase) in denervated muscle (produced by unilateral sciatic nerve transection). In order to gain a better understanding of the above mitochondrial adaptations, we also examined the effects of heat stress on autophagy-dependent mitochondrial clearance (mitophagy). Daily heat stress normalized denervation-activated induction of mitophagy (increased mitochondrial microtubule-associated protein 1A/1B-light chain3-II (LC3-II) with and without blocker of autophagosome clearance). The molecular basis of this observation was explained by the results that heat stress attenuated the denervation-induced increase in key proteins that regulate the following steps: (i) the tagging step of mitochondrial clearance (increased mitochondrial Parkin, ubiquitin-conjugated, P62/sequestosome 1 (P62/SQSTM1)); and (ii) the elongation step of autophagosome formation (increased Atg5–Atg12 conjugate and Atg16L). Overall, our results contribute to the better

Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yamagata, Kazutsune, E-mail: kyamagat@ncc.go.jp; Kitabayashi, Issay

2009-12-25

Sirt1 appear to be NAD(+)-dependent deacetylase that deacetylates histones and several non-histone proteins. In this study, we identified Sirt1 as a physical interaction partner of Tip60, which is a mammalian MYST-type histone acetyl-transferase that specifically acetylates histones H2A and H4. Although Tip60 also acetylates DNA damage-specific histone H2A variant H2AX in response to DNA damage, which is a process required for appropriate DNA damage response, overexpression of Sirt1 represses Tip60-mediated acetylation of H2AX. Furthermore, Sirt1 depletion by RNAi causes excessive acetylation of H2AX, and enhances accumulation of {gamma}-ray irradiation-induced MDC1, BRCA1, and Rad51 foci in nuclei. These findings suggest thatmore » Sirt1 functions as negative regulator of Tip60-mediated acetylation of H2AX. Moreover, Sirt1 deacetylates an acetylated Tip60 in response to DNA damage and stimulates proteasome-dependent Tip60 degradation in vivo, suggesting that Sirt1 negatively regulates the protein level of Tip60 in vivo. Sirt1 may thus repress excessive activation of the DNA damage response and Rad51-homologous recombination repair by suppressing the function of Tip60.« less

Lateral Tip Control Effects in CD-AFM Metrology: The Large Tip Limit.

PubMed

Dixson, Ronald G; Orji, Ndubuisi G; Goldband, Ryan S

2016-01-25

Sidewall sensing in critical dimension atomic force microscopes (CD-AFMs) usually involves continuous lateral dithering of the tip or the use of a control algorithm and fast response piezo actuator to position the tip in a manner that resembles touch-triggering of coordinate measuring machine (CMM) probes. All methods of tip position control, however, induce an effective tip width that may deviate from the actual geometrical tip width. Understanding the influence and dependence of the effective tip width on the dither settings and lateral stiffness of the tip can improve the measurement accuracy and uncertainty estimation for CD-AFM measurements. Since CD-AFM typically uses tips that range from 15 nm to 850 nm in geometrical width, the behavior of effective tip width throughout this range should be understood. The National Institute of Standards and Technology (NIST) has been investigating the dependence of effective tip width on the dither settings and lateral stiffness of the tip, as well as the possibility of material effects due to sample composition. For tip widths of 130 nm and lower, which also have lower lateral stiffness, the response of the effective tip width to lateral dither is greater than for larger tips. However, we have concluded that these effects will not generally result in a residual bias, provided that the tip calibration and sample measurement are performed under the same conditions. To validate that our prior conclusions about the dependence of effective tip width on lateral stiffness are valid for large CD-tips, we recently performed experiments using a very large non-CD tip with an etched plateau of approximately 2 μm width. The effective lateral stiffness of these tips is at least 20 times greater than typical CD-AFM tips, and these results supported our prior conclusions about the expected behavior for larger tips. The bottom-line importance of these latest observations is that we can now reasonably conclude that a dither slope of 3 nm

Lateral Tip Control Effects in CD-AFM Metrology: The Large Tip Limit

PubMed Central

Dixson, Ronald G.; Orji, Ndubuisi G.; Goldband, Ryan S.

2016-01-01

Sidewall sensing in critical dimension atomic force microscopes (CD-AFMs) usually involves continuous lateral dithering of the tip or the use of a control algorithm and fast response piezo actuator to position the tip in a manner that resembles touch-triggering of coordinate measuring machine (CMM) probes. All methods of tip position control, however, induce an effective tip width that may deviate from the actual geometrical tip width. Understanding the influence and dependence of the effective tip width on the dither settings and lateral stiffness of the tip can improve the measurement accuracy and uncertainty estimation for CD-AFM measurements. Since CD-AFM typically uses tips that range from 15 nm to 850 nm in geometrical width, the behavior of effective tip width throughout this range should be understood. The National Institute of Standards and Technology (NIST) has been investigating the dependence of effective tip width on the dither settings and lateral stiffness of the tip, as well as the possibility of material effects due to sample composition. For tip widths of 130 nm and lower, which also have lower lateral stiffness, the response of the effective tip width to lateral dither is greater than for larger tips. However, we have concluded that these effects will not generally result in a residual bias, provided that the tip calibration and sample measurement are performed under the same conditions. To validate that our prior conclusions about the dependence of effective tip width on lateral stiffness are valid for large CD-tips, we recently performed experiments using a very large non-CD tip with an etched plateau of approximately 2 μm width. The effective lateral stiffness of these tips is at least 20 times greater than typical CD-AFM tips, and these results supported our prior conclusions about the expected behavior for larger tips. The bottom-line importance of these latest observations is that we can now reasonably conclude that a dither slope of 3 nm

A ginseng PgTIP1 gene whose protein biological activity related to Ser(128) residue confers faster growth and enhanced salt stress tolerance in Arabidopsis.

PubMed

Li, Jia; Cai, Weiming

2015-05-01

Water movement across cellular membranes is mostly regulated by aquaporins. A tonoplast intrinsic protein PgTIP1 from Panax ginseng has been found to play an important role in plant growth and development, and also in the response of plants to abiotic stress. However, the regulation of its function and activity remains unknown. To answer this question, mutated forms of PgTIP1 were made by replacing Ser(128) with Ala (named S128A) or Asp (named S128D), and also by replacing Thr(54) with Ala (named T54A) or Asp (named T54D). Then, wild type or mutated PgTIP1 was expressed in yeast and water transport was monitored in protoplasts. The substitution of Ser(128) abolished the water channel activity of PgTIP1, while the substitution of Thr(54) did not inhibit its activity. Moreover, the overexpression of PgTIP1 but not S128A or S128D in Arabidopsis significantly increased plant growth as determined by biomass production, it also had a beneficial effect on salt stress tolerance. Importantly, the overexpression of PgTIP1 led to the altered expression of stress-related genes, which made the plants more tolerant to salt stress. Our results demonstrated that PgTIP1 conferred faster growth and enhanced tolerance to salt in Arabidopsis, and that its biological activity related to Ser(128) residue. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

THE INFLUENCE OF SERUM BINDING PROTEINS AND CLEARANCE ON THE COMPARATIVE RECEPTOR BINDING POTENCY OF ENDOCRINE ACTIVE COMPOUNDS

EPA Science Inventory

THE INFLUENCE OF SERUM BINDING PROTEINS AND CLEARANCE ON THE COMPARATIVE RECEPTOR BINDING POTENCY OF ENDOCRINE ACTIVE COMPOUNDS. JG Teeguarden1 and HA Barton2. 1ENVIRON International, Ruston LA; 2US EPA, ORD, NHEERL, ETD, Pharmacokinetics Branch, RTP, NC.

One measure of th...

[Correlation index amylase-creatinine clearance to endogenous creatinine clearance in severe preeclampsia].

PubMed

Vázquez Rodríguez, Juan Gustavo; Cruz Cruz, Polita del Rocío; Márquez Hubert, Elizabeth

2009-07-01

Tubular lesion may cause acute renal insufficiency in pregnant patients with severe preeclampsia. To describe the correlation between the amylase/creatinine clearance ratio and endogenous creatinine depuration in pregnant patients with severe preeclampsia. Transversal study (pilot study) twenty eight women with pregnancies of 20 to 40 weeks complicated by severe preeclampsia were studied. Subjects had serum and urine creatinine and amylase determinations to calculate the amylase/creatinine clearance ratio (%). According to the results, two groups were formed: group A (> 3%) and group B (< or = 3%). The correlation between amylase/creatinine clearance ratio and endogenous creatinine depuration was evaluated. measures of central tendency and dispersion, Student's t-test, Pearson correlation coefficient (r) and linear regression were used. Group A included 23 cases (82%) and group B included 5 cases (18%). Amylase/creatinine clearance ratio (%) for group A was 5.22 +/- 1.6 and for group B was 2.41 +/- 0.41 (p = 0.001). The endogenous creatinine depuration (mL /min. /1.73 m2 SC) for group A was 105.6 +/- 9.71 and for group B was 132.10 +/- 7.95 (p = 0.54). The r between amylase/creatinine clearance ratio and endogenous creatinine depuration for group A was -0.43 and for group B was -0.25. A moderately significant negative correlation exists between amylase/creatinine clearance ratio and endogenous creatinine depuration.

Aerodynamic tip desensitization in axial flow turbines

NASA Astrophysics Data System (ADS)

Dey, Debashis

The leakage flow near the tip of unshrouded rotor blades in axial turbines imposes significant thermal loads on the blade. It is also responsible for up to a third of aerodynamic losses in a turbine stage. The leakage flow, mainly induced by the pressure differential across the rotor tip section, usually rolls into a stream-wise vertical structure near the suction side part of the blade tip. The current study uses several concepts to reduce the severity of losses introduced by the leakage vortex. Three tip desensitization techniques, both active and passive, are examined. Coolant flow from a tip trench is used to counter the momentum of the leakage jet. Next, a very short winglet obtained by slightly extending the tip platform in the tangential direction is investigated. Lastly, the widely used concept of squealer tip is studied. The current investigation is performed in the Axial Flow Turbine Research Facility (AFTRF) of the Pennsylvania State University. Rotating frame five hole probe measurements as well as stationary frame phase averaged total pressure measurements downstream of a single stage turbine facility were taken. The study enables one to draw conclusions about the nature of the flowfield in the rotor tip region. It also shows that significant efficiency gains could be obtained by using some of these techniques.

Flow Instability and Flow Control Scaling Laws

NASA Astrophysics Data System (ADS)

van Ness, Daniel; Corke, Thomas; Morris, Scott

2006-11-01

A flow instability that is receptive to perturbations is present in the tip clearance leakage flow over the tip of a turbine blade. This instability was investigated through the introduction of active flow control in the viscous flow field. Control was implemented in the form of a dielectric barrier discharge created by a weakly-ionized plasma actuation arrangement. The experimental setup consisted of a low-speed linear turbine cascade made up of an array of nine Pratt & Whitney ``PakB'' turbine blades. This idealized cascade configuration was used to examine the tip clearance leakage flow that exists within the low pressure turbine stage of a gas-turbine engine. The center blade of the cascade array had a variable tip clearance up to five percent chord. Reynolds numbers based on axial blade chord varied from 10^4 to 10^5. Multi-port pressure probe measurements, as well as Stereo Particle Image Velocimetry were used to document the dependence of the instability on the frequency and amplitude of flow control perturbations. Scaling laws based on the variation of blade tip clearance height and inflow conditions were investigated. These results permitted an improved understanding of the mechanism of flow instability.

Effect of ultrasonic tip designs on intraradicular post removal.

PubMed

Aguiar, Anny Carine Barros; de Meireles, Daniely Amorim; Marques, André Augusto Franco; Sponchiado Júnior, Emílio Carlos; Garrido, Angela Delfina Bitencourt; Garcia, Lucas da Fonseca Roberti

2014-11-01

To evaluate the effect of different ultrasonic tip designs on intraradicular post removal. The crowns of forty human canine teeth were removed, and after biomechanical preparation and filling, the roots were embedded in acrylic resin blocks. The post spaces were made, and root canal molding was performed with self-cured acrylic resin. After casting (Cu-Al), the posts were cemented with zinc phosphate cement. The specimens were randomly separated into 4 groups (n = 10), as follows: G1 - no ultrasonic vibration (control); G2 - ultrasonic vibration using an elongated cylindrical-shaped and active rounded tip; G3 - ultrasonic vibration with a flattened convex and linear active tip; G4 - ultrasonic vibration with active semicircular tapered tip. Ultrasonic vibration was applied for 15 seconds on each post surface and tensile test was performed in a Universal Testing Machine (Instron 4444 - 1 mm/min). G4 presented the highest mean values, however, with no statistically significant difference in comparison to G3 (P > 0.05). G2 presented the lowest mean values with statistically significant difference to G3 and G4 (P < 0.05). Ultrasonic vibration with elongated cylindrical-shaped and active rounded tip was most effective in reducing force required for intraradicular post removal.

14 CFR 25.925 - Propeller clearance.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Propeller clearance. 25.925 Section 25.925... STANDARDS: TRANSPORT CATEGORY AIRPLANES Powerplant General § 25.925 Propeller clearance. Unless smaller clearances are substantiated, propeller clearances with the airplane at maximum weight, with the most adverse...

14 CFR 23.925 - Propeller clearance.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Propeller clearance. 23.925 Section 23.925... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Powerplant General § 23.925 Propeller clearance. Unless smaller clearances are substantiated, propeller clearances, with the airplane at the most...

14 CFR 23.925 - Propeller clearance.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Propeller clearance. 23.925 Section 23.925... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Powerplant General § 23.925 Propeller clearance. Unless smaller clearances are substantiated, propeller clearances, with the airplane at the most...

14 CFR 23.925 - Propeller clearance.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Propeller clearance. 23.925 Section 23.925... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Powerplant General § 23.925 Propeller clearance. Unless smaller clearances are substantiated, propeller clearances, with the airplane at the most...

14 CFR 25.925 - Propeller clearance.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Propeller clearance. 25.925 Section 25.925... STANDARDS: TRANSPORT CATEGORY AIRPLANES Powerplant General § 25.925 Propeller clearance. Unless smaller clearances are substantiated, propeller clearances with the airplane at maximum weight, with the most adverse...

14 CFR 25.925 - Propeller clearance.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Propeller clearance. 25.925 Section 25.925... STANDARDS: TRANSPORT CATEGORY AIRPLANES Powerplant General § 25.925 Propeller clearance. Unless smaller clearances are substantiated, propeller clearances with the airplane at maximum weight, with the most adverse...

14 CFR 25.925 - Propeller clearance.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Propeller clearance. 25.925 Section 25.925... STANDARDS: TRANSPORT CATEGORY AIRPLANES Powerplant General § 25.925 Propeller clearance. Unless smaller clearances are substantiated, propeller clearances with the airplane at maximum weight, with the most adverse...

14 CFR 23.925 - Propeller clearance.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Propeller clearance. 23.925 Section 23.925... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Powerplant General § 23.925 Propeller clearance. Unless smaller clearances are substantiated, propeller clearances, with the airplane at the most...

The tonoplast intrinsic aquaporin (TIP) subfamily of Eucalyptus grandis: Characterization of EgTIP2, a root-specific and osmotic stress-responsive gene.

PubMed

Rodrigues, Marcela I; Bravo, Juliana P; Sassaki, Flávio T; Severino, Fábio E; Maia, Ivan G

2013-12-01

Aquaporins have important roles in various physiological processes in plants, including growth, development and adaptation to stress. In this study, a gene encoding a root-specific tonoplast intrinsic aquaporin (TIP) from Eucalyptus grandis (named EgTIP2) was investigated. The root-specific expression of EgTIP2 was validated over a panel of five eucalyptus organ/tissues. In eucalyptus roots, EgTIP2 expression was significantly induced by osmotic stress imposed by PEG treatment. Histochemical analysis of transgenic tobacco lines (Nicotiana tabacum SR1) harboring an EgTIP2 promoter:GUS reporter cassette revealed major GUS staining in the vasculature and in root tips. Consistent with its osmotic-stress inducible expression in eucalyptus, EgTIP2 promoter activity was up-regulated by mannitol treatment, but was down-regulated by abscisic acid. Taken together, these results suggest that EgTIP2 might be involved in eucalyptus response to drought. Additional searches in the eucalyptus genome revealed the presence of four additional putative TIP coding genes, which could be individually assigned to the classical TIP1-5 groups. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Applying Organ Clearance Concepts in a Clinical Setting

PubMed Central

2008-01-01

Objective To teach doctor of pharmacy (PharmD) students how to apply organ clearance concepts in a clinical setting in order to optimize dose management, select the right drug product, and promote better patient-centered care practices. Design A student-focused 5-hour topic entitled "Organ Clearance Concepts: Modeling and Clinical Applications" was developed and delivered to second-year PharmD students. Active-learning techniques, such as reading assignments and thought-provoking questions, and collaborative learning techniques, such as small groups, were used. Student learning was assessed using application cards and a minute paper. Assessment Overall student responses to topic presentation were overwhelmingly positive. The teaching strategies here discussed allowed students to play an active role in their own learning process and provided the necessary connection to keep them motivated, as mentioned in the application cards and minute paper assessments. Students scored an average of 88% on the examination given at the end of the course. Conclusion By incorporating active-learning and collaborative-learning techniques in presenting material on organ clearance concept, students gained a more thorough knowledge of dose management and drug-drug interactions than if the concepts had been presented using a traditional lecture format. This knowledge will help students in solving critical patient situations in a real-world context. PMID:19214275

Tip60 degradation by adenovirus relieves transcriptional repression of viral transcriptional activator EIA.

PubMed

Gupta, A; Jha, S; Engel, D A; Ornelles, D A; Dutta, A

2013-10-17

Adenoviruses are linear double-stranded DNA viruses that infect human and rodent cell lines, occasionally transform them and cause tumors in animal models. The host cell challenges the virus in multifaceted ways to restrain viral gene expression and DNA replication, and sometimes even eliminates the infected cells by programmed cell death. To combat these challenges, adenoviruses abrogate the cellular DNA damage response pathway. Tip60 is a lysine acetyltransferase that acetylates histones and other proteins to regulate gene expression, DNA damage response, apoptosis and cell cycle regulation. Tip60 is a bona fide tumor suppressor as mice that are haploid for Tip60 are predisposed to tumors. We have discovered that Tip60 is degraded by adenovirus oncoproteins EIB55K and E4orf6 by a proteasome-mediated pathway. Tip60 binds to the immediate early adenovirus promoter and suppresses adenovirus EIA gene expression, which is a master regulator of adenovirus transcription, at least partly through retention of the virally encoded repressor pVII on this promoter. Thus, degradation of Tip60 by the adenoviral early proteins is important for efficient viral early gene transcription and for changes in expression of cellular genes.

20 CFR 653.501 - Requirements for accepting and processing clearance orders.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., DEPARTMENT OF LABOR SERVICES OF THE EMPLOYMENT SERVICE SYSTEM Agricultural Clearance Order Activity § 653.501... function of the job service as a no-fee labor exchange, that is, as a forum for bringing together employers... referred through the clearance system shall be notified to contact a local job service office, preferably...

20 CFR 653.501 - Requirements for accepting and processing clearance orders.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., DEPARTMENT OF LABOR SERVICES OF THE EMPLOYMENT SERVICE SYSTEM Agricultural Clearance Order Activity § 653.501... function of the job service as a no-fee labor exchange, that is, as a forum for bringing together employers... referred through the clearance system shall be notified to contact a local job service office, preferably...

The challenge of stereo PIV measurements in the tip gap of a transonic compressor rotor with casing treatment

NASA Astrophysics Data System (ADS)

Voges, Melanie; Willert, Christian E.; Mönig, Reinhard; Müller, Martin W.; Schiffer, Heinz-Peter

2012-03-01

This contribution is aimed at summarizing the effort taken to apply stereoscopic PIV (SPIV) measurements in the tip clearance of a transonic compressor rotor equipped with a casing treatment. A light sheet probe was placed downstream of the stator and aligned to pass the light sheet through a stator passage into the blade tip clearance of the rotor. A setup with three cameras has been used in order to record the entire 2C velocity field and the smaller area of 3C field of view at the same time instance for comparison with earlier 2C PIV results. A homogeneous seeding distribution was achieved by means of a smoke generator. The main emphasis of the SPIV measurement was to establish a data set with high spatial resolution close to the compressor casing, where the aerodynamic effects of a CT are known to be strong. The paper will discuss some major aspects of the utilized PIV data processing and point out a variety of frequently underestimated error sources that influence the overall quality of the recovered data in spite of the fact that the individual PIV recordings seemed to be of very good quality. Thus, the authors will not focus on the PIV results and related interpretation of the flow field, but on the optimization and procedures applied during setup of the experiment and data processing, respectively.

Defining toxicological tipping points in neuronal network development.

PubMed

Frank, Christopher L; Brown, Jasmine P; Wallace, Kathleen; Wambaugh, John F; Shah, Imran; Shafer, Timothy J

2018-02-02

Measuring electrical activity of neural networks by microelectrode array (MEA) has recently shown promise for screening level assessments of chemical toxicity on network development and function. Important aspects of interneuronal communication can be quantified from a single MEA recording, including individual firing rates, coordinated bursting, and measures of network synchrony, providing rich datasets to evaluate chemical effects. Further, multiple recordings can be made from the same network, including during the formation of these networks in vitro. The ability to perform multiple recording sessions over the in vitro development of network activity may provide further insight into developmental effects of neurotoxicants. In the current study, a recently described MEA-based screen of 86 compounds in primary rat cortical cultures over 12 days in vitro was revisited to establish a framework that integrates all available primary measures of electrical activity from MEA recordings into a composite metric for deviation from normal activity (total scalar perturbation). Examining scalar perturbations over time and increasing concentration of compound allowed for definition of critical concentrations or "tipping points" at which the neural networks switched from recovery to non-recovery trajectories for 42 compounds. These tipping point concentrations occurred at predominantly lower concentrations than those causing overt cell viability loss or disrupting individual network parameters, suggesting tipping points may be a more sensitive measure of network functional loss. Comparing tipping points for six compounds with plasma concentrations known to cause developmental neurotoxicity in vivo demonstrated strong concordance and suggests there is potential for using tipping points for chemical prioritization. Published by Elsevier Inc.

Fenofibrate Decreases Insulin Clearance and Insulin Secretion to Maintain Insulin Sensitivity*

PubMed Central

Ramakrishnan, Sadeesh K.; Russo, Lucia; Ghanem, Simona S.; Patel, Payal R.; Oyarce, Ana Maria; Heinrich, Garrett; Najjar, Sonia M.

2016-01-01

High fat diet reduces the expression of CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1), a transmembrane glycoprotein that promotes insulin clearance and down-regulates fatty acid synthase activity in the liver upon its phosphorylation by the insulin receptor. Because peroxisome proliferator-activated receptor α (PPARα) transcriptionally suppresses CEACAM1 expression, we herein examined whether high fat down-regulates CEACAM1 expression in a PPARα-dependent mechanism. By activating PPARα, the lipid-lowering drug fenofibrate reverses dyslipidemia and improves insulin sensitivity in type 2 diabetes in part by promoting fatty acid oxidation. Despite reducing glucose-stimulated insulin secretion, fenofibrate treatment does not result in insulin insufficiency. To examine whether this is mediated by a parallel decrease in CEACAM1-dependent hepatic insulin clearance pathways, we fed wild-type and Pparα−/− null mice a high fat diet supplemented with either fenofibrate or Wy14643, a selective PPARα agonist, and examined their effect on insulin metabolism and action. We demonstrated that the decrease in insulin secretion by fenofibrate and Wy14643 is accompanied by reduction in insulin clearance in wild-type but not Pparα−/− mice, thereby maintaining normoinsulinemia and insulin sensitivity despite continuous high fat intake. Intact insulin secretion in L-CC1 mice with protected hepatic insulin clearance and CEACAM1 levels provides in vivo evidence that insulin secretion responds to changes in insulin clearance to maintain physiologic insulin and glucose homeostasis. These results also emphasize the relevant role of hepatic insulin extraction in regulating insulin sensitivity. PMID:27662905

Experimental performance of a 16.10-centimeter-tip-diameter sweptback centrifugal compressor designed for a 6:1 pressure ratio

NASA Technical Reports Server (NTRS)

Klassen, H. A.; Wood, J. R.; Schumann, L. F.

1977-01-01

A backswept impeller with design mass flow rate of 1.033 kg/sec was tested with both a vaned diffuser and a vaneless diffuser to establish stage and impeller characteristics. Design stage pressure ratio of 5.9:1 was attained at a flow slightly lower than the design value. Flow range at design speed was 6 percent of choking flow. Impeller axial tip clearance at design speed was varied to determine effect on stage and impeller performance.

Application of an in vitro OAT assay in drug design and optimization of renal clearance.

PubMed

Soars, Matthew G; Barton, Patrick; Elkin, Lisa L; Mosure, Kathleen W; Sproston, Joanne L; Riley, Robert J

2014-07-01

1. Optimization of renal clearance is a complex balance between passive and active processes mediated by renal transporters. This work aimed to characterize the interaction of a series of compounds with rat and human organic anion transporters (OATs) and develop quantitative structure-activity relationships (QSARs) to optimize renal clearance. 2. In vitro inhibition assays were established for human OAT1 and rat Oat3 and rat in vivo renal clearance was obtained. Statistically significant quantitative relationships were explored between the compounds' physical properties, their affinity for OAT1 and oat3 and the inter-relationship with unbound renal clearance (URC) in rat. 3. Many of the compounds were actively secreted and in vitro analysis demonstrated that these were ligands for rat and human OAT transporters (IC50 values ranging from <1 to >100 µM). Application of resultant QSAR models reduced renal clearance in the rat from 24 to <0.1 ml/min/kg. Data analysis indicated that the properties associated with increasing affinity at OATs are the same as those associated with reducing URC but orthogonal in nature. 4. This study has demonstrated that OAT inhibition data and QSAR models can be successfully used to optimize rat renal clearance in vivo and provide confidence of translation to humans.

UXO clearance operation in Laos

NASA Astrophysics Data System (ADS)

Sato, Motoyuki; Kadoya, Yoshihiko

2018-04-01

Laos is one of the most seriously contaminated countries by UXO. Most of the UXO are cluster bombs, used in 1960- 70's. There is historical political background about the UXO problems in Laos. Currently, The clearance of UXO is significantly important for future economic development for Laos. It affects not only local inhabitants, but it will affects national economy. For example, UXO clearance in mountainous area can promote construction of roads, and Laos has a good possibility to be the center of transportation in Indo-Chia region. We have started a research project for evaluation of impact of UXO clearance in Laos, "The economic impact and the technological development for the elimination of unexploded ordnance (UXO) elimination in Laos". Lao National Unexploded Ordnance Programme (UXO Lao) is working in the nine most impacted provinces nationwide and it clears land for agriculture and community purposes. We recently visited Laos and observed the UXO clearance procedure conducted by UXOLAO. The technical survey for UXO clearance site to determine for operation, UXO detection by using metal detectors are organized by UXO Lao. In this paper, we will report the technical aspects of the UXO clearance in Laos.

Fitness: Tips for Staying Motivated

MedlinePlus

... life. Review these tips whenever you feel your motivation slipping. Identifying your fitness goals. American Heart Association. ... prescription. Primary Care. 2013;40:801. Physical activity: Motivation. Centers for Disease Control and Prevention. http://www. ...

Increased Glyburide Clearance in the Pregnant Mouse Model

PubMed Central

Zhou, Lin; Zhang, Yi; Hebert, Mary F.; Unadkat, Jashvant D.

2010-01-01

Glyburide (GLB) is an oral sulfonylurea, commonly used for the treatment of gestational diabetes mellitus. It has been reported that the clearance of GLB in pregnant women is significantly higher than that in nonpregnant women. The molecular mechanism by which pregnancy increases the clearance of GLB is not known, but it may be caused by increased CYP3A activity. Because liver tissue from pregnant women is not readily available, in the present study, we investigated the mechanism of such pregnancy-related changes in GLB disposition in a mouse model. We demonstrated that the systemic clearance of GLB in pregnant mice was increased approximately 2-fold (p < 0.01) compared with nonpregnant mice, a magnitude of change similar to that observed in the clinical study. Plasma protein binding of GLB in mice was not altered by pregnancy. The half-life of GLB depletion in hepatic S-9 fractions of pregnant mice was significantly shorter than that of nonpregnant mice. Moreover, GLB depletion was markedly inhibited by ketoconazole, a potent inhibitor of mouse Cyp3a, suggesting that GLB metabolism in mice is primarily mediated by hepatic Cyp3a. These data suggest that the increased systemic clearance of GLB in pregnant mice is likely caused by an increase in hepatic Cyp3a activity during pregnancy, and they provide a basis for further mechanistic understanding and analysis of pregnancy-induced alterations in the disposition of GLB and drugs that are predominantly and extensively metabolized by CYP3A/Cyp3a. PMID:20558597

Experimental short-duration techniques. [gas turbine engine tests

NASA Technical Reports Server (NTRS)

Dunn, Michael G.

1986-01-01

Short-duration facilities used for gas turbine studies are described. Data recording techniques; and instruments (thin-film heat flux gages, high-frequency response pressure measurements, total temperature probes, measurement of rotor tip speed, active measurement of tip clearance) are presented.

Probe tip heating assembly

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmitz, Roger William; Oh, Yunje

A heating assembly configured for use in mechanical testing at a scale of microns or less. The heating assembly includes a probe tip assembly configured for coupling with a transducer of the mechanical testing system. The probe tip assembly includes a probe tip heater system having a heating element, a probe tip coupled with the probe tip heater system, and a heater socket assembly. The heater socket assembly, in one example, includes a yoke and a heater interface that form a socket within the heater socket assembly. The probe tip heater system, coupled with the probe tip, is slidably receivedmore » and clamped within the socket.« less

Rational design and validation of a Tip60 histone acetyltransferase inhibitor

NASA Astrophysics Data System (ADS)

Gao, Chunxia; Bourke, Emer; Scobie, Martin; Famme, Melina Arcos; Koolmeister, Tobias; Helleday, Thomas; Eriksson, Leif A.; Lowndes, Noel F.; Brown, James A. L.

2014-06-01

Histone acetylation is required for many aspects of gene regulation, genome maintenance and metabolism and dysfunctional acetylation is implicated in numerous diseases, including cancer. Acetylation is regulated by histone acetyltransferases (HATs) and histone deacetylases and currently, few general HAT inhibitors have been described. We identified the HAT Tip60 as an excellent candidate for targeted drug development, as Tip60 is a key mediator of the DNA damage response and transcriptional co-activator. Our modeling of Tip60 indicated that the active binding pocket possesses opposite charges at each end, with the positive charges attributed to two specific side chains. We used structure based drug design to develop a novel Tip60 inhibitor, TH1834, to fit this specific pocket. We demonstrate that TH1834 significantly inhibits Tip60 activity in vitro and treating cells with TH1834 results in apoptosis and increased unrepaired DNA damage (following ionizing radiation treatment) in breast cancer but not control cell lines. Furthermore, TH1834 did not affect the activity of related HAT MOF, as indicated by H4K16Ac, demonstrating specificity. The modeling and validation of the small molecule inhibitor TH1834 represents a first step towards developing additional specific, targeted inhibitors of Tip60 that may lead to further improvements in the treatment of breast cancer.

Active Chest Tube Clearance After Cardiac Surgery Is Associated With Reduced Reexploration Rates.

PubMed

Grieshaber, Philippe; Heim, Nicolas; Herzberg, Moritz; Niemann, Bernd; Roth, Peter; Boening, Andreas

2018-06-01

Ineffective evacuation of intrathoracic fluid after cardiac surgery (retained blood syndrome [RBS]) might increase postoperative complications, morbidity, and mortality. Active tube clearance (ATC) technology using an intraluminal clearing apparatus aims at increasing chest tube drainage efficiency. This study evaluated whether ATC reduces RBS in an all-comers collective undergoing scheduled cardiac surgery with cardiopulmonary bypass and full or partial median sternotomy. In this nonrandomized prospective trial, 581 consecutive patients undergoing scheduled cardiac surgery with median sternotomy between January 2016 and December 2016 were assigned to receive conventional chest tubes (control group) or a combination of conventional tubes and as many as two ATC devices (ATC group), depending on their operation date. Postoperative occurrence of RBS (one or more of the following: reexploration for bleeding or tamponade, pericardial drainage procedure, pleural drainage procedure) and other endpoints were compared. Propensity score matching was applied. In 222 ATC patients and 222 matched control patients, RBS occurrence did not differ between the groups (ATC 16%, control 22%; p = 0.15). However, reexploration rate for bleeding or tamponade was significantly reduced in the ATC group compared with the control group (4.1% versus 9.1%, respectively; p = 0.015). The mortality of RBS patients (21%) was higher compared with patients without RBS (3.9%, p < 0.001). Among the RBS components, only reexploration (odds ratio 16, 95% confidence interval: 5.8 to 43, p < 0.001) was relevant for inhospital mortality (ATC 6.8%, control 7.7%; p = 0.71). Active tube clearance is associated with reduced reexploration rates in an all-comers collective undergoing cardiac surgery. Reexploration is the only RBS component relevant for mortality. The ATC effect does not translate into improved overall survival. Copyright © 2018 The Society of Thoracic Surgeons. Published by Elsevier Inc. All

A Scalable Heuristic for Viral Marketing Under the Tipping Model

DTIC Science & Technology

2013-09-01

removal of high-degree nodes. The rest of the paper is organized as follows. In Section 2, we provide formal definitions of the tipping model. This is...that must be activated for it to become activate as well. A Scalable Heuristic for Viral Marketing Under the Tipping Model 3 Definition 1 (Threshold...returns a set of active nodes after one time step. Definition 2 (Activation Function) Given a threshold function, θ, an ac- tivation function Aθ maps

30 CFR 18.24 - Electrical clearances.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Electrical clearances. 18.24 Section 18.24... APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction and Design Requirements § 18.24 Electrical clearances. Minimum clearances between uninsulated electrical conductor...

30 CFR 18.24 - Electrical clearances.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Electrical clearances. 18.24 Section 18.24... APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction and Design Requirements § 18.24 Electrical clearances. Minimum clearances between uninsulated electrical conductor...

30 CFR 18.24 - Electrical clearances.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Electrical clearances. 18.24 Section 18.24... APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction and Design Requirements § 18.24 Electrical clearances. Minimum clearances between uninsulated electrical conductor...

Selectively enhanced expression of prophenoloxidase activating enzyme 1 (PPAE1) at a bacteria clearance site in the white shrimp, Litopenaeus vannamei

PubMed Central

2011-01-01

Background The prophenoloxidase-activating (PO activating) system plays an important role in the crustacean innate immunity, particularly in wound healing and pathogen defense. A key member of this system is prophenoloxidase-activating enzyme (PPAE), which is the direct activator of prophenoloxidase (proPO). Despite their importance in crustacean PO activating system, the studies on them remain limited. Results Here we report on a PPAE of white shrimp, Litopenaeus vannamei (lvPPAE1), which showed 94% similarity to PPAE1 of Penaeus monodon. We found that lvPPAE1 in fluid hemocytes was down regulated after challenge by Vibrio harveyi but was enhanced when shrimps were exposed to a bacteria-rich environment for long-term. In vivo gene silence of lvPPAE1 by RNAi can significantly reduce the phenoloxidase activity (PO) and increase the susceptibility of shrimps to V. harveyi. Although lvPPAE1 was down-regulated in fluid hemocytes by Vibrio challenge, its expression increased significantly in gill after bacteria injection, which is the primary bacteria-clearance tissue. Conclusion Suppressed expression in fluid hemocytes and enhanced expression in gill indicates selectively enhanced expression at the bacterial clearance site. This is a novel feature for PPAE expression. The results will contribute to our understanding of the PO activating system in crustaceans. PMID:22208405

22 CFR 16.6 - Security clearances.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Security clearances. 16.6 Section 16.6 Foreign Relations DEPARTMENT OF STATE PERSONNEL FOREIGN SERVICE GRIEVANCE SYSTEM § 16.6 Security clearances. The agencies shall use their best endeavors to expedite security clearances whenever necessary to ensure a fair...

22 CFR 16.6 - Security clearances.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Security clearances. 16.6 Section 16.6 Foreign Relations DEPARTMENT OF STATE PERSONNEL FOREIGN SERVICE GRIEVANCE SYSTEM § 16.6 Security clearances. The agencies shall use their best endeavors to expedite security clearances whenever necessary to ensure a fair...

22 CFR 16.6 - Security clearances.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Security clearances. 16.6 Section 16.6 Foreign Relations DEPARTMENT OF STATE PERSONNEL FOREIGN SERVICE GRIEVANCE SYSTEM § 16.6 Security clearances. The agencies shall use their best endeavors to expedite security clearances whenever necessary to ensure a fair...

Impact of fraction unbound, CYP3A, and CYP2D6 in vivo activities, and other potential covariates to the clearance of tramadol enantiomers in patients with neuropathic pain.

PubMed

de Moraes, Natália V; Lauretti, Gabriela R; Coelho, Eduardo B; Godoy, Ana Leonor P C; Neves, Daniel V; Lanchote, Vera L

2016-04-01

The pharmacokinetics of tramadol is characterized by a large interindividual variability, which is partially attributed to polymorphic CYP2D6 metabolism. The contribution of CYP3A, CYP2B6, fraction unbound, and other potential covariates remains unknown. This study aimed to investigate the contribution of in vivo activities of cytochrome P450 (CYP) 2D6 and 3A as well as other potential covariates (CYP2B6 genotype to the SNP g.15631G>T, fraction unbound, age, body weight, creatinine clearance) to the enantioselective pharmacokinetics of tramadol. Thirty patients with neuropathic pain and phenotyped as CYP2D6 extensive metabolizers were treated with a single oral dose of 100 mg tramadol. Multiple linear regressions were performed to determine the contribution of CYP activities and other potential covariates to the clearance of tramadol enantiomers. The apparent total clearances were 44.9 (19.1-102-2) L/h and 55.2 (14.8-126.0) L/h for (+)- and (-)-tramadol, respectively [data presented as median (minimum-maximum)]. Between 79 and 83% of the overall variation in apparent clearance of tramadol enantiomers was explained by fraction unbound, CYP2D6, and CYP3A in vivo activities and body weight. Fraction unbound explained 47 and 41% of the variation in clearance of (+)-tramadol and (-)-tramadol, respectively. Individually, CYP2D6 and CYP3A activities were shown to have moderate contribution on clearance of tramadol enantiomers (11-16% and 11-18%, respectively). In conclusion, factors affecting fraction unbound of drugs (such as hyperglycemia or co-administration of drugs highly bound to plasma proteins) should be monitored, because this parameter dominates the elimination of tramadol enantiomers. © 2015 Société Française de Pharmacologie et de Thérapeutique.

Acute Mucociliary Clearance Response to Aerobic Exercise in Smokers.

PubMed

Ramos, Ercy M C; Vanderlei, Luiz Carlos M; Ito, Juliana T; Lima, Fabiano F; Rodrigues, Fernanda M M; Manzano, Beatriz M; Fernandes, Rômulo A; Cecílio, Michel J; Toledo-Arruda, Alessandra C; Ramos, Dionei

2015-11-01

Mucociliary clearance is the main defense mechanism of the respiratory system, and it is influenced by several stimuli, including aerobic exercise and cigarette smoking. We evaluated the acute response of mucociliary clearance to aerobic exercise in smokers and nonsmokers compared with that found after acute smoking and smoking combined with exercise. Also, we investigated whether there was a correlation between mucociliary clearance and the autonomic nervous system under these conditions. Twenty-one smokers were evaluated for mucociliary clearance by saccharin transit time (STT), and the response of the autonomic nervous system was evaluated by heart rate variability after aerobic exercise, after exercise followed by smoking, after acute smoking, and after rest. For comparison, 17 nonsmokers were also assessed during exercise. Repeated-measures analysis of variance with the Tukey test or the Friedman test followed by the Dunn test was used to evaluate the STT, autonomic response, and other variables to exercise and/or smoking in smokers. A paired t test or Wilcoxon test was used to analyze responses to exercise in nonsmokers. Correlations were evaluated using Pearson or Spearman coefficients. The STT was reduced after exercise in both groups, with similar responses between them. Other stimuli also reduced the STT. The STT showed a negative correlation with sympathetic activity in smokers and a positive correlation with the parasympathetic system in nonsmokers. Although impaired in smokers, mucociliary clearance responded to the stimulus of exercise, as demonstrated by similar STTs compared with nonsmokers. This response was correlated with the autonomic nervous system in both groups. In smokers, mucociliary clearance also responded to the stimuli of smoking and exercise followed by smoking. Copyright © 2015 by Daedalus Enterprises.

Arctic climate tipping points.

PubMed

Lenton, Timothy M

2012-02-01

There is widespread concern that anthropogenic global warming will trigger Arctic climate tipping points. The Arctic has a long history of natural, abrupt climate changes, which together with current observations and model projections, can help us to identify which parts of the Arctic climate system might pass future tipping points. Here the climate tipping points are defined, noting that not all of them involve bifurcations leading to irreversible change. Past abrupt climate changes in the Arctic are briefly reviewed. Then, the current behaviour of a range of Arctic systems is summarised. Looking ahead, a range of potential tipping phenomena are described. This leads to a revised and expanded list of potential Arctic climate tipping elements, whose likelihood is assessed, in terms of how much warming will be required to tip them. Finally, the available responses are considered, especially the prospects for avoiding Arctic climate tipping points.

[Over projected tip].

PubMed

Duron, J-B; Nguyen, P S; Levet, Y; Bardot, J; Aiach, G

2014-12-01

Overprojected tip is a pretty usual request not easy to manage. Preop analysis is crucial in order to evaluate tip support and skin thickness and ability to retract. For example, if the skin is very thick and has poor chance to retract, the surgeon should be very careful in the tip projection decreasing to avoid a skin pollybeak deformity. In such cases, he has to analyze the facial proportions, especially other areas projection (radix, dorsum and chin) and think about augmenting them to balance the profile rather than decreasing tip projection. Correction should always be conducted incrementally, starting with weakening the tip support mechanisms and, only if necessary, continue with alar cartilage interruption. This can be performed on many areas (lateral cruras, domes, medial cruras) and with several techniques (resection or interruption+overlapping). Copyright © 2014 Elsevier Masson SAS. All rights reserved.

The tipping point: A mathematical model for the profit-driven abandonment of restaurant tipping.

PubMed

Clifton, Sara M; Herbers, Eileen; Chen, Jack; Abrams, Daniel M

2018-02-01

The custom of voluntarily tipping for services rendered has gone in and out of fashion in America since its introduction in the 19th century. Restaurant owners that ban tipping in their establishments often claim that social justice drives their decisions, but we show that rational profit-maximization may also justify the decisions. Here, we propose a conceptual model of restaurant competition for staff and customers, and we show that there exists a critical conventional tip rate at which restaurant owners should eliminate tipping to maximize profits. Because the conventional tip rate has been increasing steadily for the last several decades, our model suggests that restaurant owners may abandon tipping en masse when that critical tip rate is reached.

The tipping point: A mathematical model for the profit-driven abandonment of restaurant tipping

NASA Astrophysics Data System (ADS)

Clifton, Sara M.; Herbers, Eileen; Chen, Jack; Abrams, Daniel M.

2018-02-01

The custom of voluntarily tipping for services rendered has gone in and out of fashion in America since its introduction in the 19th century. Restaurant owners that ban tipping in their establishments often claim that social justice drives their decisions, but we show that rational profit-maximization may also justify the decisions. Here, we propose a conceptual model of restaurant competition for staff and customers, and we show that there exists a critical conventional tip rate at which restaurant owners should eliminate tipping to maximize profits. Because the conventional tip rate has been increasing steadily for the last several decades, our model suggests that restaurant owners may abandon tipping en masse when that critical tip rate is reached.

Helping Your Child Learn Math: Math Tips for Parents

ERIC Educational Resources Information Center

Nebraska Department of Education, 2010

2010-01-01

This paper presents tips, activities, resources, and games that parents can use to help their children become more proficient in math. Some helpful tips offered are: (1) Be positive; (2) Play family games; (3) Avoid stereotypes; (4) Choose gifts that develop problem solving skills; (5) Expand your children's horizons; (6) Buy or borrow library…

Make Celebrations Fun, Healthy, and Active: 10 Tips to Creating Healthy, Active Events

MedlinePlus

United States Department of Agriculture 10 tips Nutrition Education Series MyPlate MyWins Based on the Dietary Guidelines for Americans Make celebrations ... out some of the recipes on WhatsCooking.fns.usda.gov. 8 Keep it simple Have others participate ...

48 CFR 945.603-70 - Plant clearance function.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Plant clearance function... Plant clearance function. If the plant clearance function has not been formally delegated to another Federal agency, the contracting officer shall assume all responsibilities of the plant clearance officer...

48 CFR 945.603-70 - Plant clearance function.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Plant clearance function... Plant clearance function. If the plant clearance function has not been formally delegated to another Federal agency, the contracting officer shall assume all responsibilities of the plant clearance officer...

48 CFR 801.602-76 - Business clearance review.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Business clearance review... Authority, and Responsibilities 801.602-76 Business clearance review. (a) A business clearance review is a... obtain a business clearance review prior to award of any contract, task or delivery order, or blanket...

48 CFR 801.602-76 - Business clearance review.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Business clearance review... Authority, and Responsibilities 801.602-76 Business clearance review. (a) A business clearance review is a... obtain a business clearance review prior to award of any contract, task or delivery order, or blanket...

30 CFR 18.24 - Electrical clearances.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Requirements § 18.24 Electrical clearances. Minimum clearances between uninsulated electrical conductor surfaces, or between uninsulated conductor surfaces and grounded metal surfaces, within the enclosure shall...

30 CFR 18.24 - Electrical clearances.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Requirements § 18.24 Electrical clearances. Minimum clearances between uninsulated electrical conductor surfaces, or between uninsulated conductor surfaces and grounded metal surfaces, within the enclosure shall...

Technology Tips

ERIC Educational Resources Information Center

Mathematics Teacher, 2004

2004-01-01

Some inexpensive or free ways that enable to capture and use images in work are mentioned. The first tip demonstrates the methods of using some of the built-in capabilities of the Macintosh and Windows-based PC operating systems, and the second tip describes methods to capture and create images using SnagIt.

45 CFR 675.3 - Medical clearance criteria.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 3 2014-10-01 2014-10-01 false Medical clearance criteria. 675.3 Section 675.3 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION MEDICAL CLEARANCE PROCESS FOR DEPLOYMENT TO ANTARCTICA § 675.3 Medical clearance criteria. (a) The USAP shall...

45 CFR 675.3 - Medical clearance criteria.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 3 2013-10-01 2013-10-01 false Medical clearance criteria. 675.3 Section 675.3 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION MEDICAL CLEARANCE PROCESS FOR DEPLOYMENT TO ANTARCTICA § 675.3 Medical clearance criteria. (a) The USAP shall...

45 CFR 675.3 - Medical clearance criteria.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 3 2011-10-01 2011-10-01 false Medical clearance criteria. 675.3 Section 675.3 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION MEDICAL CLEARANCE PROCESS FOR DEPLOYMENT TO ANTARCTICA § 675.3 Medical clearance criteria. (a) The USAP shall...

Controlled deposition of palladium nanodendrites on the tips of gold nanorods and their enhanced catalytic activity.

PubMed

Su, Gaoxing; Jiang, Huaqiao; Zhu, Hongyan; Lv, Jing-Jing; Yang, Guohai; Yan, Bing; Zhu, Jun-Jie

2017-08-31

Plasmonic Au-Pd nanostructures have drawn significant attention for use in heterogeneous catalysis. In this study, palladium nanodendrite-tipped gold nanorods (PdND-T-AuNRs) were subjected to a facile fabrication under mild reaction conditions. The palladium amounts on the two tips were tunable. In the preparation of PdND-T-AuNRs, dense capped AuNRs, a low reaction temperature, and suitable stabilizing agents were identified as critical reaction parameters for controlling palladium nanodendrites deposited on both ends of AuNRs. After overgrowth with palladium nanodendrites, the longitudinal surface plasmonic resonance peaks of PdND-T-AuNRs were red-shifted from 810 nm to 980 nm. The electrocatalytic activity of PdND-T-AuNRs for ethanol oxidation was examined, which was a bit weaker than that of cuboid core-shell Au-Pd nanodendrites; however, PdND-T-AuNRs were more stable in ethanol electrooxidation. Moreover, the photocatalytic activity of PdND-T-AuNRs for Suzuki cross-coupling reactions was investigated. At room temperature, nearly 100% yield was obtained under laser irradiation. The results can further enhance our capability of fine-tuning the optical, electronic, and catalytic properties of the bimetallic Au-Pd nanostructures.

24 CFR 3285.305 - Clearance under homes.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Clearance under homes. 3285.305... URBAN DEVELOPMENT MODEL MANUFACTURED HOME INSTALLATION STANDARDS Foundations § 3285.305 Clearance under homes. A minimum clearance of 12 inches must be maintained between the lowest member of the main frame...

24 CFR 3285.305 - Clearance under homes.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Clearance under homes. 3285.305... URBAN DEVELOPMENT MODEL MANUFACTURED HOME INSTALLATION STANDARDS Foundations § 3285.305 Clearance under homes. A minimum clearance of 12 inches must be maintained between the lowest member of the main frame...

24 CFR 3285.305 - Clearance under homes.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Clearance under homes. 3285.305... URBAN DEVELOPMENT MODEL MANUFACTURED HOME INSTALLATION STANDARDS Foundations § 3285.305 Clearance under homes. A minimum clearance of 12 inches must be maintained between the lowest member of the main frame...

24 CFR 3285.305 - Clearance under homes.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Clearance under homes. 3285.305... URBAN DEVELOPMENT MODEL MANUFACTURED HOME INSTALLATION STANDARDS Foundations § 3285.305 Clearance under homes. A minimum clearance of 12 inches must be maintained between the lowest member of the main frame...

24 CFR 3285.305 - Clearance under homes.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Clearance under homes. 3285.305... URBAN DEVELOPMENT MODEL MANUFACTURED HOME INSTALLATION STANDARDS Foundations § 3285.305 Clearance under homes. A minimum clearance of 12 inches must be maintained between the lowest member of the main frame...

Imaging Lung Clearance of Radiolabeled Tumor Cells to Study Mice with Normal, Activated or Depleted Natural Killer (NK) Cells

NASA Astrophysics Data System (ADS)

Kulkarni, P. V.; Bennett, M.; Constantinescu, A.; Arora, V.; Viguet, M.; Antich, P.; Parkey, R. W.; Mathews, D.; Mason, R. P.; Oz, O. K.

2003-08-01

Lung clearance of 51CR and 125I iododeoxyuridine (IUDR) labeled cancer cells assess NK cell activity. It is desirable to develop noninvasive imaging technique to assess NK activity in mice. We labeled target YAC-1 tumor cells with 125I, 111In, 99mTc, or 67Ga and injected I.V. into three groups of BALB/c mice. Animals were treated with medium (group I), 300mg/kg cyclophosmamide (CY) to kill NK cell (group II), or anti-LY49C/1) (ab')2 mAb to augment NK function (group III). Lungs were removed 15 min or 2 h later for tissue counting. Control and treated mice were imaged every 5 min with a scintillating camera for 1 h after 15 min of infusion of the 111In labeled cells. Lung clearance increased after 15 min (lodging: 60-80%) and (2 h retention: 3-7%). Similar results were obtained with all the isotopes studied. Images distinguished the control and treated mice for lung activity. Cells labeled with 111In, 99mTc or 67Ga are cleared similar to those labeled with 51Cr or 125I. NK cell destruction of tumor cells may be assessed by noninvasive imaging method either by SPECT (99mTc, 111In, 67Ga) or by PET (68Ga).

Dimerization of glycoprotein Ibα is not sufficient to induce platelet clearance.

PubMed

Liang, X; Syed, A K; Russell, S R; Ware, J; Li, R

2016-02-01

ESSENTIALS: Many anti-glycoprotein (GP)Ibα antibodies induce platelet clearance in a dimer-dependent manner. Characterization of monoclonal antibodies that bind the mechanosensitive domain (MSD) of GPIbα. An anti-MSD antibody binds two copies of GPIbα in platelets but does not induce platelet clearance. The prevailing clustering model of GPIbα signaling is incorrect or needs revision. The mechanism of platelet clearance is not clear. Many antibodies binding the membrane-distal ligand-binding domain of glycoprotein (GP)Ibα induce rapid clearance of platelets and acute thrombocytopenia, which requires the bifurcated antibody structure. It was thought that binding of these antibodies induced lateral dimerization or clustering of GPIbα in the plasma membrane, which leads to downstream signaling and platelet clearance. However, many antibodies targeting GPIbβ and GPIX, which are associated with GPIbα in the GPIb-IX complex, do not induce platelet clearance, which is in contradiction to the clustering model. To test whether dimerization or clustering of GPIbα is sufficient to transmit the signal that leads to platelet clearance. We have recently raised several mAbs targeting the mechanosensitive domain (MSD) of GPIbα. Binding of these anti-MSD antibodies was characterized with biochemical methods. Their ability to stimulate platelets and induce platelet clearance in mice was assessed. Infusion of anti-MSD antibodies does not cause thrombocytopenia in mice. These antibodies show no detectable effects on platelet activation and aggregation in vitro. Further biochemical investigation showed that the anti-MSD antibody 3D1 binds two copies of GPIbα on the platelet surface. Therefore, lateral dimerization of GPIbα induced by antibody binding is not sufficient to initiate GPIb-IX signaling and induce platelet clearance. Our results suggest that a factor other than or in addition to clustering of GPIbα is required to induce platelet clearance. © 2015 International

46 CFR 56.75-10 - Joint clearance.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Joint clearance. 56.75-10 Section 56.75-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PIPING SYSTEMS AND APPURTENANCES Brazing § 56.75-10 Joint clearance. (a) The clearance between surfaces to be joined shall be no...

Evaluation of lung clearance of inhaled pertechnegas.

PubMed

Fanti, S; Compagnone, G; Pancaldi, D; Franchi, R; Corbelli, C; Marengo, M; Onofri, C; Galassi, R; Levorato, M; Monetti, N

1996-02-01

Pertechnegas is a new ventilation agent produced by modifying the atmosphere of combustion of Technegas. Due to its rapid disappearance from the lungs, Pertechnegas has been suggested as useful in measuring pulmonary epithelial permeability. This study aimed to assess the reliability of ventilation scans with Pertechnegas to evaluate alveolar-capillary permeability. Six non-smokers with no evidence of pulmonary disease were investigated. Scintigraphic data were used to evaluate the site of Pertechnegas deposition (by assessing the Penetration Index [PI] of the gas), its clearance rate (by calculating the time to half-clearance [T1/2]) and its lung distribution (by means of a pixel-by-pixel analysis. PI measurements produced a mean value of 88.8 +/- 13.3% (range 69-117%). Time activity curves showed a fast clearance in all cases (mean T1/2 = 10.7 +/- 2.1 min, range 8.1-14.3 min). Comparison of statistical indices of uniform deposition (skewness and kurtosis) indicated satisfactory homogeneity of Pertechnegas distribution throughout the lungs. These data show that after inhalation Pertechnegas has a peripheral deposition and a homogeneous distribution in the lungs and is rapidly cleared through the alveolar-capillary barrier. In conclusion Pertechnegas can be recommended as a potential radiopharmaceutical for studying the pulmonary epithelial barrier.

Transient FTY720 treatment promotes immune-mediated clearance of a chronic viral infection.

PubMed

Premenko-Lanier, Mary; Moseley, Nelson B; Pruett, Sarah T; Romagnoli, Pablo A; Altman, John D

2008-08-14

For a wide variety of microbial pathogens, the outcome of the infection is indeterminate. In some individuals the microbe is cleared, but in others it establishes a chronic infection, and the factors that tip this balance are often unknown. In a widely used model of chronic viral infection, C57BL/6 mice clear the Armstrong strain of lymphocytic choriomeningitis virus (LCMV), but the clone 13 strain persists. Here we show that the Armstrong strain induces a profound lymphopenia at days 1-3 after infection, but the clone 13 strain does not. If we transiently augment lymphopenia by treating the clone-13-infected mice with the drug FTY720 at days 0-2 after infection, the mice successfully clear the infection by day 30. Clearance does not occur when CD4 T cells are absent at the time of treatment, indicating that the drug is not exerting direct antiviral effects. Notably, FTY720 treatment of an already established persistent infection also leads to viral clearance. In both models, FTY720 treatment preserves or augments LCMV-specific CD4 and CD8 T-cell responses, a result that is counter-intuitive because FTY720 is generally regarded as a new immunosuppressive agent. Because FTY720 targets host pathways that are completely evolutionarily conserved, our results may be translatable into new immunotherapies for the treatment of chronic microbial infections in humans.

Tip cells: master regulators of tubulogenesis?

PubMed

Weavers, Helen; Skaer, Helen

2014-07-01

The normal development of an organ depends on the coordinated regulation of multiple cell activities. Focusing on tubulogenesis, we review the role of specialised cells or groups of cells that are selected from within tissue primordia and differentiate at the outgrowing tips or leading edge of developing tubules. Tip or leading cells develop distinctive patterns of gene expression that enable them to act both as sensors and transmitters of intercellular signalling. This enables them to explore the environment, respond to both tissue intrinsic signals and extrinsic cues from surrounding tissues and to regulate the behaviour of their neighbours, including the setting of cell fate, patterning cell division, inducing polarity and promoting cell movement and cell rearrangements by neighbour exchange. Tip cells are also able to transmit mechanical tension to promote tissue remodelling and, by interacting with the extracellular matrix, they can dictate migratory pathways and organ shape. Where separate tubular structures fuse to form networks, as in the airways of insects or the vascular system of vertebrates, specialised fusion tip cells act to interconnect disparate elements of the developing network. Finally, we consider their importance in the maturation of mature physiological function and in the development of disease. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

A similitude method and the corresponding blade design of a low-speed large-scale axial compressor rotor

NASA Astrophysics Data System (ADS)

Yu, Chenghai; Ma, Ning; Wang, Kai; Du, Juan; Van den Braembussche, R. A.; Lin, Feng

2014-04-01

A similitude method to model the tip clearance flow in a high-speed compressor with a low-speed model is presented in this paper. The first step of this method is the derivation of similarity criteria for tip clearance flow, on the basis of an inviscid model of tip clearance flow. The aerodynamic parameters needed for the model design are then obtained from a numerical simulation of the target high-speed compressor rotor. According to the aerodynamic and geometric parameters of the target compressor rotor, a large-scale low-speed rotor blade is designed with an inverse blade design program. In order to validate the similitude method, the features of tip clearance flow in the low-speed model compressor are compared with the ones in the high-speed compressor at both design and small flow rate points. It is found that not only the trajectory of the tip leakage vortex but also the interface between the tip leakage flow and the incoming main flow in the high-speed compressor match well with that of its low speed model. These results validate the effectiveness of the similitude method for the tip clearance flow proposed in this paper.

Relationship between rhinosinusitis symptoms and mucociliary clearance time.

PubMed

Boatsman, Justin E; Calhoun, Karen H; Ryan, Matthew W

2006-03-01

To determine the correlation between rhinosinusitis symptoms as assessed by the Sino-Nasal Outcomes Test-20 (SNOT-20) and mucociliary clearance as assessed by the saccharin method. This was a cross-sectional study of 50 adult volunteers. Subjects completed the SNOT-20, and mucociliary clearance was determined with the saccharine method. Correlation coefficients (Spearman's Rho) were calculated for the global SNOT-20 score. The SNOT-20 scores varied from 20 to 54 (mean 30.28) with a possible range of 20 to 100. Clearance times varied from 418 to 2865 seconds (mean 999). There was no significant correlation between global SNOT-20 score and clearance time (r = 0.196). There is no significant correlation between rhinosinusitis symptoms as assessed by SNOT-20 scores and mucociliary clearance. Mucociliary clearance is important for the health of the sinonasal cavities, but clearance time does not appear to be associated with symptom severity in the population studied. A-1b.

Nano-Wilhelmy investigation of dynamic wetting properties of AFM tips through tip-nanobubble interaction

PubMed Central

Wang, Yuliang; Wang, Huimin; Bi, Shusheng; Guo, Bin

2016-01-01

The dynamic wetting properties of atomic force microscopy (AFM) tips are of much concern in many AFM-related measurement, fabrication, and manipulation applications. In this study, the wetting properties of silicon and silicon nitride AFM tips are investigated through dynamic contact angle measurement using a nano-Wilhelmy balance based method. This is done by capillary force measurement during extension and retraction motion of AFM tips relative to interfacial nanobubbles. The working principle of the proposed method and mathematic models for dynamic contact angle measurement are presented. Geometric models of AFM tips were constructed using scanning electronic microscopy (SEM) images taken from different view directions. The detailed process of tip-nanobubble interaction was investigated using force-distance curves of AFM on nanobubbles. Several parameters including nanobubble height, adhesion and capillary force between tip and nanobubbles are extracted. The variation of these parameters was studied over nanobubble surfaces. The dynamic contact angles of the AFM tips were calculated from the capillary force measurements. The proposed method provides direct measurement of dynamic contact angles for AFM tips and can also be taken as a general approach for nanoscale dynamic wetting property investigation. PMID:27452115

Nano-Wilhelmy investigation of dynamic wetting properties of AFM tips through tip-nanobubble interaction

NASA Astrophysics Data System (ADS)

Wang, Yuliang; Wang, Huimin; Bi, Shusheng; Guo, Bin

2016-07-01

The dynamic wetting properties of atomic force microscopy (AFM) tips are of much concern in many AFM-related measurement, fabrication, and manipulation applications. In this study, the wetting properties of silicon and silicon nitride AFM tips are investigated through dynamic contact angle measurement using a nano-Wilhelmy balance based method. This is done by capillary force measurement during extension and retraction motion of AFM tips relative to interfacial nanobubbles. The working principle of the proposed method and mathematic models for dynamic contact angle measurement are presented. Geometric models of AFM tips were constructed using scanning electronic microscopy (SEM) images taken from different view directions. The detailed process of tip-nanobubble interaction was investigated using force-distance curves of AFM on nanobubbles. Several parameters including nanobubble height, adhesion and capillary force between tip and nanobubbles are extracted. The variation of these parameters was studied over nanobubble surfaces. The dynamic contact angles of the AFM tips were calculated from the capillary force measurements. The proposed method provides direct measurement of dynamic contact angles for AFM tips and can also be taken as a general approach for nanoscale dynamic wetting property investigation.

Dissatisfaction with Nasal Tip Shape: Secondary Tip Maneuvers.

PubMed

Moyer, Jeffrey S

2018-06-01

Dissatisfaction with the appearance of the nasal tip is a common compliant in patients seeking revision surgery after rhinoplasty. Revision rhinoplasty is more technically difficult and unpredictable given the frequent presence of scar contracture, impaired skin envelope quality, and missing alar cartilage. This article describes some of the more common causes for tip revision surgery and techniques to address these abnormalities. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Carbon Nanotubes in the Human Respiratory Tract-Clearance Modeling.

PubMed

Sturm, Robert

2017-03-01

Clearance of single-wall carbon nanotubes (SWCNT, diameter: 5 nm) and multi-wall carbon nanotubes (MWCNT, diameter: 50 nm) in the respiratory tract was predicted for various age groups (infants, children, adolescents, and adults). The model was founded on the assumption that lung clearance takes place in three distinct phases: (i) fast mucociliary clearance, (ii) slow bronchial clearance, and (iii) alveolar clearance. To each of these phases a specific fraction of deposited particles was attributed, the amount of which depended on particles' geometry and particles' deposition sites in the respiratory system. Clearance velocities were expressed by respective clearance half-times ranging from several hours in the case of fast clearance to tens of days in the case of slow clearance. Results of the simulations clearly demonstrate that for the specific deposition scenario (sitting, nasal breathing) considered here fast clearance fraction exhibits a slight decrease with increasing age, but total clearance times (i.e. time spans, within which 100% of the deposited particulate mass are removed) are rather constant among the age groups. Nanotubes deposited in the respiratory bronchioles and alveoli are usually subject to a long-term storage in these structures and, thus, may trigger malignant transformations in adjacent cells and tissues. © The Author 2017. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.

Clearance of polonium-210-enriched cigarette smoke from the rat trachea and lung.

PubMed

Cohen, B S; Harley, N H; Tso, T C

1985-06-30

The distribution and clearance of alpha radioactivity in the lungs of rats were measured after inhalation of smoke from cigarettes highly enriched in 210Po. Female Fischer rats were exposed daily for 6 months to smoke from cigarettes with 500 times the normal content of 210Po. Control rats were exposed to standard cigarette smoke. Animals were serially withdrawn and killed. After necropsy the trachea, major bronchi, larynx, and nasopharynx were examined for surface alpha activity by an etched track technique utilizing cellulose nitrate detectors. Areas of accumulated activity were seen on samples of larynx from rats exposed to the 210Po-enriched cigarettes. No other local accumulations were seen on the airways. The lower lungs were analyzed radiochemically for 210Po. Both radiochemical analysis and track measurements showed highly elevated activity concentrations in rats exposed to the 210Po-enriched cigarettes. Following withdrawal from smoking, both short- and long-term clearance components were seen. The parameters which fit the postexposure data for clearance of the lung burden cannot fit the buildup during the exposure period.

Tip60 HAT Action Mediates Environmental Enrichment Induced Cognitive Restoration.

PubMed

Xu, Songjun; Panikker, Priyalakshmi; Iqbal, Sahira; Elefant, Felice

2016-01-01

Environmental enrichment (EE) conditions have beneficial effects for reinstating cognitive ability in neuropathological disorders like Alzheimer's disease (AD). While EE benefits involve epigenetic gene control mechanisms that comprise histone acetylation, the histone acetyltransferases (HATs) involved remain largely unknown. Here, we examine a role for Tip60 HAT action in mediating activity- dependent beneficial neuroadaptations to EE using the Drosophila CNS mushroom body (MB) as a well-characterized cognition model. We show that flies raised under EE conditions display enhanced MB axonal outgrowth, synaptic marker protein production, histone acetylation induction and transcriptional activation of cognition linked genes when compared to their genotypically identical siblings raised under isolated conditions. Further, these beneficial changes are impaired in both Tip60 HAT mutant flies and APP neurodegenerative flies. While EE conditions provide some beneficial neuroadaptive changes in the APP neurodegenerative fly MB, such positive changes are significantly enhanced by increasing MB Tip60 HAT levels. Our results implicate Tip60 as a critical mediator of EE-induced benefits, and provide broad insights into synergistic behavioral and epigenetic based therapeutic approaches for treatment of cognitive disorder.

High exposure, spontaneous clearance, and low incidence of active Helicobacter pylori infection: the Sorbo San Basile study.

PubMed

Luzza, Francesco; Suraci, Evelina; Larussa, Tiziana; Leone, Isabella; Imeneo, Maria

2014-08-01

A decreased incidence of Helicobacter pylori infection has been prospected to occur nowadays. To evaluate the exposure to H. pylori, prevalence and incidence of active infection, and related risk factors in the general population. In a small town of Southern Italy (932 inhabitants), 595 (3-97 years) and 157 (12-82 years) subjects among those with no evidence of active H. pylori infection participated at baseline and 10 years later, respectively. A questionnaire was administered. Active H. pylori infection was assessed by (13) C-urea breath test (UBT). Serum VacA and CagA antibodies were determined. Of 518 subjects who were evaluated by both UBT and serology, 310 (59.8%) were UBT positive, 479 (92.4%) VacA positive, and 369 (71.2%) CagA positive. Subjects UBT negative and serology positive were 169 (32%), ranging 1 (14.2%) to 29 (82.8%) from last to first decades of life. Age, female gender, and people per room were independent risk factors for subjects UBT positive compared to those UBT negative and serology positive. Ten years later, subjects who became UBT positive were four of 157 (0.25% per year) while those who became seropositive for VacA and/or CagA were 17 of 26 (6.5% per year). H. pylori infection is highly dynamic with wide range of spontaneous clearance. It is easily cleared in the first decades of life, more recent years, less crowded homes, and males. It disappears and recurs more often than it was previously thought, implying that the current decline in its prevalence is due to real clearance instead of a fall in infection rate. © 2014 John Wiley & Sons Ltd.

HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses

PubMed Central

Col, Edwige; Caron, Cécile; Chable-Bessia, Christine; Legube, Gaelle; Gazzeri, Sylvie; Komatsu, Yasuhiko; Yoshida, Minoru; Benkirane, Monsef; Trouche, Didier; Khochbin, Saadi

2005-01-01

HIV-1 transactivator Tat uses cellular acetylation signalling by targeting several cellular histone acetyltransferases (HAT) to optimize its various functions. Although Tip60 was the first HAT identified to interact with Tat, the biological significance of this interaction has remained obscure. We had previously shown that Tat represses Tip60 HAT activity. Here, a new mechanism of Tip60 neutralization by Tat is described, where Tip60 is identified as a substrate for the newly reported p300/CBP-associated E4-type ubiquitin-ligase activity, and Tat uses this mechanism to induce the polyubiquitination and degradation of Tip60. Tip60 targeting by Tat results in a dramatic impairment of the Tip60-dependent apoptotic cell response to DNA damage. These data reveal yet unknown strategies developed by HIV-1 to increase cell resistance to genotoxic stresses and show a role of Tat as a modulator of cellular protein ubiquitination. PMID:16001085

NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex.

PubMed

Adamowicz, Marek; Vermezovic, Jelena; d'Adda di Fagagna, Fabrizio

2016-08-23

The DNA damage response (DDR) signal transduction pathway is responsible for sensing DNA damage and further relaying this signal into the cell. ATM is an apical DDR kinase that orchestrates the activation and the recruitment of downstream DDR factors to induce cell-cycle arrest and repair. We have previously shown that NOTCH1 inhibits ATM activation upon DNA damage, but the underlying mechanism remains unclear. Here, we show that NOTCH1 does not impair ATM recruitment to DNA double-strand breaks (DSBs). Rather, NOTCH1 prevents binding of FOXO3a and KAT5/Tip60 to ATM through a mechanism in which NOTCH1 competes with FOXO3a for ATM binding. Lack of FOXO3a binding to ATM leads to the loss of KAT5/Tip60 association with ATM. Moreover, expression of NOTCH1 or depletion of ATM impairs the formation of the FOXO3a-KAT5/Tip60 protein complex. Finally, we show that pharmacological induction of FOXO3a nuclear localization sensitizes NOTCH1-driven cancers to DNA-damage-induced cell death. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Nanostar probes for tip-enhanced spectroscopy

NASA Astrophysics Data System (ADS)

Kim, Woong; Kim, Nara; Park, Joon Won; Kim, Zee Hwan

2015-12-01

To overcome the current limit of tip-enhanced spectroscopy that is based on metallic nano-probes, we developed a new scanning probe with a metallic nanostar, a nanoparticle with sharp spikes. A Au nanoparticle of 5 nm was first attached to the end of a tip through DNA-DNA hybridization and mechanical pick-up. The nanoparticle was converted to a nanostar with a core diameter of ~70 nm and spike lengths between 50 nm and 80 nm through the reduction of Au3+ with ascorbic acid in the presence of Ag+. Fabrication yields of such tips exceeded 60%, and more than 80% of such tips showed a mechanical durability sufficient for use in scanning microscopy. Effectiveness of the new probes for tip-enhanced Raman scattering (TERS) and tip-enhanced fluorescence (TEF) was confirmed. The probes exhibited the necessary enhancement for TEF, and the tip-on and tip-off ratios varied between 5 and 100. This large tip-to-tip variability may arise from the uncontrolled orientation of the apexes of the spike with respect to the sample surface, which calls for further fabrication improvement. The result overall supports a new fabrication approach for the probe that is effective for tip-enhanced spectroscopy.To overcome the current limit of tip-enhanced spectroscopy that is based on metallic nano-probes, we developed a new scanning probe with a metallic nanostar, a nanoparticle with sharp spikes. A Au nanoparticle of 5 nm was first attached to the end of a tip through DNA-DNA hybridization and mechanical pick-up. The nanoparticle was converted to a nanostar with a core diameter of ~70 nm and spike lengths between 50 nm and 80 nm through the reduction of Au3+ with ascorbic acid in the presence of Ag+. Fabrication yields of such tips exceeded 60%, and more than 80% of such tips showed a mechanical durability sufficient for use in scanning microscopy. Effectiveness of the new probes for tip-enhanced Raman scattering (TERS) and tip-enhanced fluorescence (TEF) was confirmed. The probes exhibited

78 FR 64523 - Agency Information Collection Activities: Vessel Entrance or Clearance Statement

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-29

... respondents or record keepers from the collection of information (a total capital/startup costs and operations... vessel data at time of formal entrance and clearance in U.S. ports. The form allows the master to attest... Responses per Respondent: 22. Estimated Total Annual Responses: 264,000. Estimated Time per Response: 30...

48 CFR 245.602-70 - Plant clearance procedures.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Plant clearance procedures... Disposal 245.602-70 Plant clearance procedures. Follow the procedures at PGI 245.602-70 for establishing and processing a plant clearance case. ...

48 CFR 245.602-70 - Plant clearance procedures.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Plant clearance procedures... Disposal 245.602-70 Plant clearance procedures. Follow the procedures at PGI 245.602-70 for establishing and processing a plant clearance case. ...

48 CFR 245.602-70 - Plant clearance procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Plant clearance procedures... Disposal 245.602-70 Plant clearance procedures. Follow the procedures at PGI 245.602-70 for establishing and processing a plant clearance case. ...

48 CFR 245.602-70 - Plant clearance procedures.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Plant clearance procedures... Disposal 245.602-70 Plant clearance procedures. Follow the procedures at PGI 245.602-70 for establishing and processing a plant clearance case. ...

Integrating the Clearance in NPP Residual Material Management

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garcia-Bermejo, R.; Lamela, B.

Previous Experiences in decommissioning projects are being used to optimize the residual material management in NPP, metallic scrap usually. The approach is based in the availability of a materials Clearance MARSSIM-based methodology developed and licensed in Spain. A typical project includes the integration of segregation, decontamination, clearance, quality control and quality assurance activities. The design is based in the clearance methodology features translating them into standard operational procedures. In terms of ecological taxes and final disposal costs, significant amounts of money could be saved with this type of approaches. The last clearance project managed a total amount of 405 tonsmore » scrap metal and a similar amount of other residual materials occupying a volume of 1500 m{sup 3}. After less than a year of field works 251 tons were finally recycled in a non-licensed smelting facility. The balance was disposed as LILW. In the planning phase the estimated cost savings were 4.5 Meuro. However, today a VLLW option is available in European countries so, the estimated cost savings are reduced to 1.2 Meuro. In conclusion: the application of materials clearance in NPP decommissioning lessons learnt to the NPP residual material management is an interesting management option. This practice is currently going on in Spanish NPP and, in a preliminary view, is consistent with the new MARSAME Draft. An interesting parameter is the cost of 1 m3 of recyclable scrap. The above estimates are very project specific because in the segregation process other residual materials were involved. If the effect of this other materials is removed the estimated Unit Cost were in this project around 1700 euro/m{sup 3}, this figure is clearly below the above VLLW disposal cost of 2600 euro. In a future project it appears feasible to descend to 839 euro/m{sup 3} and if it became routine values and is used in big Decommissioning projects, around 600 euro/m{sup 3} or below

76 FR 50993 - Agency Information Collection Activities: Proposed Collection; Comment Request-Generic Clearance...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-17

...: Proposed Collection; Comment Request--Generic Clearance to Conduct Methodological Testing, Surveys, Focus... proposed information collection. This information collection will conduct research by methodological... Methodological Testing, Surveys, Focus Groups, and Related Tools to Improve the Management of Federal Nutrition...

Effect of neurotrauma on hepatic drug clearance.

PubMed

Boucher, B A; Kuhl, D A; Fabian, T C; Robertson, J T

1991-11-01

Lorazepam, antipyrine, and indocyanine green were administered to 10 patients with severe head injuries as marker substrates of hepatic glucuronidation, oxidation, and hepatic blood flow, respectively. Pharmacokinetic parameter estimates were determined at baseline (20 to 80 hours after injury) and up to three additional times thereafter (study days 4, 7, and 14). Antipyrine clearance was increased significantly from baseline (0.50 +/- 0.31 ml/min/kg) on study days 4, 7, and 14 (p less than 0.0001). Increases in antipyrine clearance from baseline to the last study day were observed in all study patients ranging from 14% to 207%. A significant increase was also observed in lorazepam clearance on study day 14 relative to baseline (1.39 +/- 0.56 ml/min/kg) (p less than 0.005). Increases in lorazepam clearance occurred in seven of nine patients over time ranging from 9% to 130%. The unbound fraction of lorazepam did not change significantly over the study period. Likewise, no significant change was observed in the clearance of indocyanine green over time. Antipyrine clearance and alpha 1-acid glycoprotein (r = 0.41), and lorazepam clearance and C-reactive protein (r = -0.38) were significantly correlated (p less than 0.05). Similarly, antipyrine and lorazepam clearances were significantly correlated with injury severity based on the Acute Physiologic and Chronic Health Evaluation (APACHE II) score (r = -0.43 and r = -0.37, respectively). These findings suggest that hepatic oxidative and conjugative metabolism increase significantly over time in patients after acute head injury. An awareness of the potential for pharmacokinetic alterations in similarly metabolized drugs used for patients with severe head injuries is recommended.

Simple sampling strategy for measuring inulin renal clearance.

PubMed

Horio, Masaru; Imai, Enyu; Yasuda, Yoshinari; Hishida, Akira; Matsuo, Seiichi

2009-02-01

In the standard method of inulin clearance (Cin), three sets of serum and urine samples are collected during a 2-hour clearance period. For a practical use of this method, sampling should be the minimal number allowable while still providing enough accuracy. The aim of this study was to evaluate the validity of inulin renal clearance with assumed single urine collection with a period such as 30, 60 or 90 minutes. Inulin clearance data collected by the standard method from 737 individuals were used. Changes of serum inulin concentrations between 45 and 105 minutes after the start of the infusion were analyzed. We used first urine collection to calculate the inulin clearance with single urine collection (Cin-30 min). We assumed single urine collection for 60 or 90 minutes by combining the urine data of the consecutive 30-minute periods. Inulin clearances (Cin-60 min, Cin-90 min) were calculated from the assumed single urine collections, respectively. Serum inulin concentration did not reach equilibrium during the clearance period. It increased in subjects with low glomerular filtration rate (GFR) and decreased in subjects with normal GFR. The amount of the change was small and -0.5 +/- 12.6% in subjects with GFR over 30 ml/min per 1.73 m(2). Cin-30 min, Cin-60 min and Cin-90 min showed high correlation coefficients against Cin-ST (0.962, 0.988 and 0.998, respectively). Systemic biases in these clearances were negligible (under 1 ml/min per 1.73 m(2)). Root mean square error (RMSE) were 10.4, 5.3 and 2.3 ml/min per 1.73 m(2) for Cin-30 min, Cin-60 min and Cin-90 min, respectively. These data indicated that accuracy of inulin clearance depends on the duration of the urine collection period. Inulin clearance with a single urine collection is a convenient method. We showed that single urine collection for 30 minutes or a longer period has reasonable accuracy in calculation of inulin clearance. We propose a method of inulin clearance with single urine collection for 60

Child Transportation Safety Tips.

ERIC Educational Resources Information Center

National Highway Traffic Safety Administration (DOT), Washington, DC.

This document presents nine tips regarding safe infant and child transportation, each tip explained in one to two pages. The tips are as follows: (1) quick safety seat checkup; (2) where should your child ride? (3) how to protect your new baby in the car; (4) what safety seat to use for a big baby or toddler? (5) how should preschool and school…

78 FR 77027 - Overhead Clearance (Air-Draft) Accidents

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-20

... No. USCG-2013-0466] Overhead Clearance (Air-Draft) Accidents AGENCY: Coast Guard, DHS. ACTION... clearance (air-draft) accidents. In its petition, which calls for vessel masters to be provided with accurate vertical air draft information, a maritime organization has described 16 overhead clearance...

Confusion in Using Pre-Departure Clearances

DOT National Transportation Integrated Search

1996-12-20

In 1990, the FAA implemented the Pre-Departure Clearance (PDC) program at a : number of U.S. airports. This system allows pilots to obtain IFR clearances : through aircraft ACARS units prior to taxi-out, thus eliminating the need for : verbal communi...

Aerial Refueling Clearance Initiation Request

DTIC Science & Technology

2016-07-14

and receiver agencies. The AR Clearance Initiation Request document recognizes the requirement for definitive aerial refueling agreements between...and contractual tanker support requests from one organization or nation to another. The AR Clearance Initiation Request document is not intended to...proprietary, sensitive, classified or otherwise restricted information. ARSAG documents, as prepared, are not DOD, MOD or NATO standards, but provide

78 FR 44133 - Agency Information Collection Activities; Proposed Collection; Comment Request: Generic Clearance...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-23

... Qualitative Feedback on Agency Service Delivery, National Institute of Neurological Disorders and Stroke... Qualitative Feedback on Agency Service Delivery'' to OMB for approval under the Paperwork Reduction Act ([email protected] . SUPPLEMENTARY INFORMATION: Title: Generic Clearance for the Collection of Qualitative...

78 FR 21118 - Agency Information Collection Activities; Comment Request; Streamlined Clearance Process for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-09

...; Comment Request; Streamlined Clearance Process for Discretionary Grants AGENCY: Department of Education... also helps the public understand the Department's information collection requirements and provide the... for Discretionary Grants OMB Control Number: 1894-0001 Type of Review: An extension of an existing...

76 FR 74802 - Agency Information Collection Activities: Proposed Collection; Comment Request; Generic Clearance...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-01

.... Currie, Program Analyst, Office of policy for Extramural Research Administration, 6705 Rockledge Drive... perceptions and opinions, but are not statistical surveys that yield quantitative results that can be... generic clearance for qualitative information will not be used for quantitative information collections...

Alveolar Edema Fluid Clearance and Acute Lung Injury

PubMed Central

Berthiaume, Yves; Matthay, Michael A.

2009-01-01

Although lung-protective ventilation strategies have substantially reduced mortality of acute lung injury patients there is still a need for new therapies that can further decrease mortality in patients with acute lung injury. Studies of epithelial ion and fluid transport across the distal pulmonary epithelia have provided important new concepts regarding potential new therapies for acute lung injury. Overall, there is convincing evidence that the alveolar epithelium is not only a tight epithelial barrier that resists the movement of edema fluid into the alveoli, but it is also actively involved in the transport of ions and solutes, a process that is essential for edema fluid clearance and the resolution of acute lung injury. The objective of this article is to consider some areas of recent progress in the field of alveolar fluid transport under normal and pathologic conditions. Vectorial ion transport across the alveolar and distal airway epithelia is the primary determinant of alveolar fluid clearance. The general paradigm is that active Na+ and Cl− transport drives net alveolar fluid clearance, as demonstrated in several different species, including the human lung. Although these transport processes can be impaired in severe lung injury, multiple experimental studies suggest that upregulation of Na+ and Cl− transport might be an effective therapy in acute lung injury. We will review mechanisms involved in pharmacological modulation of ion transport in lung injury with a special focus on the use of β-adrenergic agonists which has generated considerable interest and is a promising therapy for clinical acute lung injury. PMID:17604701

Dielectrophoretic positioning of single nanoparticles on atomic force microscope tips for tip-enhanced Raman spectroscopy.

PubMed

Leiterer, Christian; Deckert-Gaudig, Tanja; Singh, Prabha; Wirth, Janina; Deckert, Volker; Fritzsche, Wolfgang

2015-05-01

Tip-enhanced Raman spectroscopy, a combination of Raman spectroscopy and scanning probe microscopy, is a powerful technique to detect the vibrational fingerprint of molecules at the nanometer scale. A metal nanoparticle at the apex of an atomic force microscope tip leads to a large enhancement of the electromagnetic field when illuminated with an appropriate wavelength, resulting in an increased Raman signal. A controlled positioning of individual nanoparticles at the tip would improve the reproducibility of the probes and is quite demanding due to usually serial and labor-intensive approaches. In contrast to commonly used submicron manipulation techniques, dielectrophoresis allows a parallel and scalable production, and provides a novel approach toward reproducible and at the same time affordable tip-enhanced Raman spectroscopy tips. We demonstrate the successful positioning of an individual plasmonic nanoparticle on a commercial atomic force microscope tip by dielectrophoresis followed by experimental proof of the Raman signal enhancing capabilities of such tips. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

48 CFR 945.670-1 - Plant clearance function.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Plant clearance function... MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 945.670-1 Plant clearance function. If the plant clearance function has not been formally delegated to another Federal agency, the...

48 CFR 945.670-1 - Plant clearance function.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Plant clearance function... MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 945.670-1 Plant clearance function. If the plant clearance function has not been formally delegated to another Federal agency, the...

Ducted fan inlet/exit and rotor tip flow improvements for vertical lift systems

NASA Astrophysics Data System (ADS)

Akturk, Ali

elevated forward flight velocities. The (DDF) is self-adjusting in a wide forward flight velocity range. DDFs corrective aerodynamic in influence becomes more pronounced with increasing flight velocity due to its inherent design properties. RANS simulations of the flow around rotor blades and duct geometry in the rotating frame of reference provided a comprehensive description of the tip leakage and passage flow in the flow environment of the two ducted fan research facilities developed throughout this thesis. The aerodynamic measurements and results of the RANS simulation showed good agreement especially near the tip region. A number of novel tip treatments based on custom designed pressure side extensions were introduced. Various tip leakage mitigation schemes were introduced by varying the chordwise location and the width of the extension in the circumferential direction. The current study showed that a proper selection of the pressure side bump location and width were the two critical parameters in influencing the success of the tip leakage mitigation approach. Significant gains in axial mean velocity component were observed when a proper pressure side tip extension was used. It is also observed that an effective tip leakage mitigation scheme significantly reduced the tangential velocity component near the tip of the axial fan blade. Reduced tip clearance related flow interactions were essential in improving the energy efficiency and range of ducted fan based vehicle. Full and inclined pressure side tip squealers were designed. Squealer tips were effective in changing the overall trajectory of the tip vortex to a higher path in radial direction. The interaction of rotor blades and tip vortex was effectively reduced and aerodynamic performance of the rotor blades was improved. The overall aerodynamic gain was a measurable reduction in leakage mass flow rate. This leakage reduction increased thrust significantly. Full and inclined pressure side tip squealers increased

AHERA CLEARANCE AT TWENTY ABATEMENT SITES

EPA Science Inventory

A study was conducted during the summer of 1988 to document Asbestos Hazard Emergency Response Act (AHERA) clearance air-sampling practices and clearance concentrations of airborne asbestos at 20 asbestos-abatement sites in New Jersey. Each abatement took place in a school buildi...

AHERA CLEARANCE AT TWENTY ABATEMENT SITES

EPA Science Inventory

A study was conducted during the summer of 1988 to document Asbestos Hazard Emergency Response Act (AHERA) clearance air sampling practices and clearance concentrations of airborne asbestos at 20 asbestos-abatement sites in New Jersey. ach abatement took place in a school buildin...

Progress Toward a Bulk Micromachined Tunneling Tip Microaccelerometer

NASA Technical Reports Server (NTRS)

Frank T. Hartley, Ben Dolgen, Paul M. Zavracky

1995-01-01

Ultrasensitive accelerometers are needed for microgravity measurement of orbital drag and active isolation systems. We have designed an accelerometer capable of measuring accelerations of the order of 10(i) g. A tunneling tip sensor can be used as a position sensor with a potential performance advantage of two orders of magnitude over capacitive sensors. In this paper, we disclose our progress in the fabrication and measurement of a bulk microaccelerometer which employs a tunneling tip. Fully assembled accelerometers consisting of four separate die have been fabricated. The device employs a unique folded spring system with a low spring constant. To protect the tunneling tip, we have employed electrostatic clamping. Stiction has not been observed, but the required clamping voltage is greater than expected. We have developed a simple model to analyze our results.

Shear joint capability versus bolt clearance

NASA Technical Reports Server (NTRS)

Lee, H. M.

1992-01-01

The results of a conservative analysis approach into the determination of shear joint strength capability for typical space-flight hardware as a function of the bolt-hole clearance specified in the design are presented. These joints are comprised of high-strength steel fasteners and abutments constructed of aluminum alloys familiar to the aerospace industry. A general analytical expression was first arrived at which relates bolt-hole clearance to the bolt shear load required to place all joint fasteners into a shear transferring position. Extension of this work allowed the analytical development of joint load capability as a function of the number of fasteners, shear strength of the bolt, bolt-hole clearance, and the desired factor of safety. Analysis results clearly indicate that a typical space-flight hardware joint can withstand significant loading when less than ideal bolt hole clearances are used in the design.

A combined piezoelectric composite actuator and its application to wing/blade tips

NASA Astrophysics Data System (ADS)

Ha, Kwangtae

A novel combined piezoelectric-composite actuator configuration is proposed and analytically modeled in this work. The actuator is a low complexity, active compliant mechanism obtained by coupling a modified star cross sectional configuration composite beam with a helicoidal bimorph piezoelectric actuator coiled around it. This novel actuator is a good candidate as a hinge tension-torsion bar actuator for a helicopter rotor blade flap or blade tip and mirror rotational positioning. In the wing tip case, the tip deflection angle is different only according to the aerodynamic moment depending on the hinge position of the actuator along the chord and applied voltage because there is no centrifugal force. For an active blade tip subject to incompressible flow and 2D quasi steady airloads, its twist angle is related not only to aerodynamic moment and applied voltage but also to coupling terms, such as the trapeze effect and the tennis racquet effect. Results show the benefit of hinge position aft of the aerodynamic center, such that the blade tip response is amplified by airloads. Contrary to this effect, results also show that the centrifugal effects and inertial effect cause an amplitude reduction in the response. Summation of these effects determines the overall blade tip response. The results for a certain hinge position of Xh=1.5% chord aft of the quarter chord point proves that the tip deflection target design range of beta ∈ [-2,+2] can be achieved for all pitch angle configurations chosen.

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Prom Health and Safety Tips

MedlinePlus

... Halloween Prom Tips Spring Break Valentine Tips Winter Holiday Tips 12 Ways Holiday Song Healthy Living Check-Ups are Important Check- ... Test Wash Hands Stay Warm Have a Healthy Holiday Don’t Drink and Drive Widgets Healthy People ...

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2010-01-01

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2011-01-01

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2010-01-01

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2013-01-01

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Tip60 HAT Action Mediates Environmental Enrichment Induced Cognitive Restoration

PubMed Central

Xu, Songjun; Panikker, Priyalakshmi; Iqbal, Sahira; Elefant, Felice

2016-01-01

Environmental enrichment (EE) conditions have beneficial effects for reinstating cognitive ability in neuropathological disorders like Alzheimer’s disease (AD). While EE benefits involve epigenetic gene control mechanisms that comprise histone acetylation, the histone acetyltransferases (HATs) involved remain largely unknown. Here, we examine a role for Tip60 HAT action in mediating activity- dependent beneficial neuroadaptations to EE using the Drosophila CNS mushroom body (MB) as a well-characterized cognition model. We show that flies raised under EE conditions display enhanced MB axonal outgrowth, synaptic marker protein production, histone acetylation induction and transcriptional activation of cognition linked genes when compared to their genotypically identical siblings raised under isolated conditions. Further, these beneficial changes are impaired in both Tip60 HAT mutant flies and APP neurodegenerative flies. While EE conditions provide some beneficial neuroadaptive changes in the APP neurodegenerative fly MB, such positive changes are significantly enhanced by increasing MB Tip60 HAT levels. Our results implicate Tip60 as a critical mediator of EE-induced benefits, and provide broad insights into synergistic behavioral and epigenetic based therapeutic approaches for treatment of cognitive disorder. PMID:27454757

A Numerical Analysis on the Effects of Self-Excited Tip Flow Unsteadiness and Upstream Blade Row Interactions on the Performance Predictions of a Transonic Compressor

NASA Astrophysics Data System (ADS)

Heberling, Brian

Computational fluid dynamics (CFD) simulations can offer a detailed view of the complex flow fields within an axial compressor and greatly aid the design process. However, the desire for quick turnaround times raises the question of how exact the model must be. At design conditions, steady CFD simulating an isolated blade row can accurately predict the performance of a rotor. However, as a compressor is throttled and mass flow rate decreased, axial flow becomes weaker making the capturing of unsteadiness, wakes, or other flow features more important. The unsteadiness of the tip clearance flow and upstream blade wake can have a significant impact on a rotor. At off-design conditions, time-accurate simulations or modeling multiple blade rows can become necessary in order to receive accurate performance predictions. Unsteady and multi- bladerow simulations are computationally expensive, especially when used in conjunction. It is important to understand which features are important to model in order to accurately capture a compressor's performance. CFD simulations of a transonic axial compressor throttling from the design point to stall are presented. The importance of capturing the unsteadiness of the rotor tip clearance flow versus capturing upstream blade-row interactions is examined through steady and unsteady, single- and multi-bladerow computations. It is shown that there are significant differences at near stall conditions between the different types of simulations.

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2010-04-01

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Clearance of polonium-210-enriched cigarette smoke from the rat trachea and lung

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cohen, B.S.; Harley, N.H.; Tso, T.C.

The distribution and clearance of alpha radioactivity in the lungs of rats were measured after inhalation of smoke from cigarettes highly enriched in /sup 210/Po. Female Fischer rats were exposed daily for 6 months to smoke from cigarettes with 500 times the normal content of /sup 210/Po. Control rats were exposed to standard cigarette smoke. Animals were serially withdrawn and killed. After necropsy the trachea, major bronchi, larynx, and nasopharynx were examined for surface alpha activity by an etched track technique utilizing cellulose nitrate detectors. Areas of accumulated activity were seen on samples of larynx from rats exposed to themore » /sup 210/Po-enriched cigarettes. No other local accumulations were seen on the airways. The lower lungs were analyzed radiochemically for /sup 210/Po. Both radiochemical analysis and track measurements showed highly elevated activity concentrations in rats exposed to the /sup 210/Po-enriched cigarettes. Following withdrawal from smoking, both short- and long-term clearance components were seen. The parameters which fit the postexposure data for clearance of the lung burden cannot fit the buildup during the exposure period.« less

The clearance mechanism of chilled blood platelets.

PubMed