Science.gov

Sample records for activities general safety

  1. Social safety, self-rated general health and physical activity: changes in area crime, area safety feelings and the role of social cohesion.

    PubMed

    Ruijsbroek, Annemarie; Droomers, Mariël; Groenewegen, Peter P; Hardyns, Wim; Stronks, Karien

    2015-01-01

    The aim of this study was to examine whether changes over time in reported area crime and perceived area safety were related to self-rated general health and physical activity (PA), in order to provide support for a causal relationship between social safety and health. Additionally, we investigated whether social cohesion protects the residents against the negative impact of unsafe areas on health and PA. Multilevel logistic regression analyses were performed on Dutch survey data, including 47,926 respondents living in 2974 areas. An increase in area level unsafety feelings between 2009 and 2011 was associated with more people reporting poor general health in 2012 in that area, but was not related to PA. Changes in reported area crime were not related to either poor general health or PA. The social cohesion in the area did not modify the effect of changes in social safety on health and PA. The results suggest that tackling feelings of unsafety in an area might contribute to the better general health of the residents. Because changes in area social safety were not associated with PA, we found no leads that such health benefits were achieved through an increase in physical activity. PMID:25463916

  2. Home Safety for People with Alzheimer's Disease: General Safety Concerns

    MedlinePlus

    ... Referral Center Alzheimer's Disease Education and Referral Center Alzheimer's Disease Education and Referral Center Home About Alzheimer’s ... NAPA) About ADEAR Home Safety for People with Alzheimer's Disease General Safety Concerns People with Alzheimer's disease ...

  3. Deriving and applying generally applicable safety principles

    SciTech Connect

    Spray, S.D.

    1998-08-01

    The nuclear detonation safety of modern nuclear weapons depends on a coordinated safety theme incorporating three general safety principles: isolation, inoperability, and incompatibility. The success of this approach has encouraged them to study whether these and/or other principles might be useful in other applications. Not surprisingly, no additional first-principles (based on physical laws) have been identified. However, a more widely applicable definition and application of the principle-based approach has been developed, resulting in a selection of strategies that are basically subsets and varied combinations of the more general principles above. However, identification of principles to be relied on is only one step in providing a safe design. As one other important example, coordinating overall architecture and strategy is essential: the authors term this a safety theme.

  4. General administrative activities

    SciTech Connect

    Cottrell, W.B.

    1982-07-01

    Significant safety-related activities reported during March and April, which are not covered elsewhere in this issue, are summarized here. The Advisory Committee on Reactor Safeguards (ACRS) issued several reports on a variety of topics of current concern to the Nuclear Regulatory Commission (NRC). A recent NRC draft report identifies preliminary ranking of safety issues. The NRC is establishing a new Office of Investigations. The NRC also released a list of plants now under construction which it suspects will be canceled or indefinitely deferred. Four speeches by NRC Commissioners are summarized, as is the only Research Information Letter issued during the report period. Last is a listing of a variety of safety-related topics.

  5. Generalized implementation of software safety policies

    NASA Technical Reports Server (NTRS)

    Knight, John C.; Wika, Kevin G.

    1994-01-01

    As part of a research program in the engineering of software for safety-critical systems, we are performing two case studies. The first case study, which is well underway, is a safety-critical medical application. The second, which is just starting, is a digital control system for a nuclear research reactor. Our goal is to use these case studies to permit us to obtain a better understanding of the issues facing developers of safety-critical systems, and to provide a vehicle for the assessment of research ideas. The case studies are not based on the analysis of existing software development by others. Instead, we are attempting to create software for new and novel systems in a process that ultimately will involve all phases of the software lifecycle. In this abstract, we summarize our results to date in a small part of this project, namely the determination and classification of policies related to software safety that must be enforced to ensure safe operation. We hypothesize that this classification will permit a general approach to the implementation of a policy enforcement mechanism.

  6. 29 CFR 1926.20 - General safety and health provisions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 8 2010-07-01 2010-07-01 false General safety and health provisions. 1926.20 Section 1926.20 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR CONSTRUCTION General Safety and...

  7. Apollo experience report: Safety activities

    NASA Technical Reports Server (NTRS)

    Rice, C. N.

    1975-01-01

    A description is given of the flight safety experiences gained during the Apollo Program and safety, from the viewpoint of program management, engineering, mission planning, and ground test operations was discussed. Emphasis is placed on the methods used to identify the risks involved in flight and in certain ground test operations. In addition, there are discussions on the management and engineering activities used to eliminate or reduce these risks.

  8. Safety activities in small businesses

    PubMed Central

    Sinclair, Raymond C.; Cunningham, Thomas R.

    2015-01-01

    Background Workplace injuries occur at higher rates in smaller firms than in larger firms, and the number of workplace safety activities appear to be inversely associated with those rates. Predictors of safety activities are rarely studied. Methods This study uses data from a national random survey of firms (n = 722) with less than 250 employees conducted in 2002. Results We found that, regardless of firm size or industry, safety activities were more common in 2002 than they were in a similar 1983 study. Having had an OSHA inspection in the last five years and firm size were stronger predictors of safety activities than industry hazardousness and manager’s perceptions of hazardousness. All four variables were significant predictors (β range .19 to .28; R2 = .27). Conclusions Further progress in the prevention of injuries in small firms will require attention to factors likely subsumed within the firm size variable, especially the relative lack of slack resources that might be devoted to safety activities. PMID:26339124

  9. Earthquake Safety: Activities for Children.

    ERIC Educational Resources Information Center

    Federal Emergency Management Agency, Washington, DC.

    Lessons on earthquake safety involving planning, preparation, and practice are presented in this booklet for teachers. Included are classroom activities designed for K-6 students, teaching notes, "Learning Links" that summarize interdisciplinary connections, a set of 15 masters for reproducing transparencies, handouts, and worksheets. Part 1 shows…

  10. Fuel Safety Activities in Korea

    SciTech Connect

    Auh, Geun-Sun; Shin, A.D.; Lee, J.S.; Woo, S.W.; Ryu, Y.H.; Kim, Jun-Hwan; Kim, S.K.; Jeong, Y.H.

    2007-07-01

    The current regulatory requirements for fuel performance were based on earlier test data of fresh or low burnup Zircaloy fuels of less than 40 GWD/MTU. Most countries have not changed the current regulatory requirements even if they are actively investigating the high burnup and new cladding alloy effects. Korea agrees with commonly accepted international consensus that although there are technical issues requiring resolutions, these issues do not constitute immediate safety concerns. The high burnup fuel reactor performance experiences of Korea do not show any major problems even if there have been some burnup related fuel failures which are described in the paper. KINS has recommended the industry to have lower fuel failure rates than 1-2 per 50,000 fuel rods. A research project of High Burnup Fuel Safety Tests and Evaluations has started in 2002 under a joint cooperation of KAERI/KNFC/KEPRI and KINS to obtain performance results of high burnup fuel and to develop evaluation technologies of high burnup fuel safety issues. From 1998, KINS has closely monitored and actively participated in international activities such as OECD/NEA CABRI Water Loop Program to reflect on regulatory requirements if needed. KINS will closely monitor the high burnup fuel performances of Korea to strength the regulatory activities if needed. The research activities in Korea including of LOCA and RIA being performed at KAERI with active supports of the industry are summarized in the paper. (authors)

  11. Safety in Aquatic Activities. Sports Safety Series. Monograph No. 5.

    ERIC Educational Resources Information Center

    Borozne, Joseph, Ed.; And Others

    The prevention of injuries and control of hazards in aquatic activities is outlined. Discussions include the causes and prevention of aquatic accidents, aquatic safety in the basic instructional program, the design of public swimming facilities, and safety considerations in pool operation and administration. A chapter is devoted to each of the…

  12. Participatory design of a preliminary safety checklist for general practice

    PubMed Central

    Bowie, Paul; Ferguson, Julie; MacLeod, Marion; Kennedy, Susan; de Wet, Carl; McNab, Duncan; Kelly, Moya; McKay, John; Atkinson, Sarah

    2015-01-01

    Background The use of checklists to minimise errors is well established in high reliability, safety-critical industries. In health care there is growing interest in checklists to standardise checking processes and ensure task completion, and so provide further systemic defences against error and patient harm. However, in UK general practice there is limited experience of safety checklist use. Aim To identify workplace hazards that impact on safety, health and wellbeing, and performance, and codesign a standardised checklist process. Design and setting Application of mixed methods to identify system hazards in Scottish general practices and develop a safety checklist based on human factors design principles. Method A multiprofessional ‘expert’ group (n = 7) and experienced front-line GPs, nurses, and practice managers (n = 18) identified system hazards and developed and validated a preliminary checklist using a combination of literature review, documentation review, consensus building workshops using a mini-Delphi process, and completion of content validity index exercise. Results A prototype safety checklist was developed and validated consisting of six safety domains (for example, medicines management), 22 sub-categories (for example, emergency drug supplies) and 78 related items (for example, stock balancing, secure drug storage, and cold chain temperature recording). Conclusion Hazards in the general practice work system were prioritised that can potentially impact on the safety, health and wellbeing of patients, GP team members, and practice performance, and a necessary safety checklist prototype was designed. However, checklist efficacy in improving safety processes and outcomes is dependent on user commitment, and support from leaders and promotional champions. Although further usability development and testing is necessary, the concept should be of interest in the UK and internationally. PMID:25918338

  13. Safety of general anaesthesia and surgery in acute hepatic porphyria.

    PubMed Central

    Dover, S B; Plenderleith, L; Moore, M R; McColl, K E

    1994-01-01

    Patients with acute hepatic porphyria are denied essential operations because of concern that general anaesthesia and surgery will precipitate a life threatening porphyric crisis. This study assessed the safety of surgery under general anaesthesia in these patients. A combined prospective and retrospective case note study, with a biochemical study, was conducted in 25 patients with acute hepatic porphyria undergoing 38 surgical operations. Clinical outcome measures were survival and occurrence of porphyric crisis after surgery. The biochemical activity of porphyria was assessed by measurement of the perioperative 24 hour excretion of the haem precursors delta amino-laevulinic acid (ALA) and porphobilinogen (PBG). There were no deaths or crises after 29 operations in 19 patients who were known to have porphyria before their surgery, and therefore given only appropriate drugs. These operations include such major procedures as mitral valve replacement, hip replacement, coronary artery grafting, cholecystectomies, and renal transplantation. In eight of these patients the urinary excretion of ALA and PBG were studied, and showed no sustained postoperative increase. Nine operations were performed in eight patients before the diagnosis of porphyria was known and who thus received routine anaesthetic agents. Seven of these patients developed a postoperative porphyric crisis. Two of them died. It is concluded therefore that even the most major surgery can be undertaken safely in patients with porphyria. The risk is for undiagnosed cases. PMID:7926916

  14. Efficacy and safety of endoscopic submucosal dissection under general anesthesia

    PubMed Central

    Yamashita, Kanefumi; Shiwaku, Hironari; Ohmiya, Toshihiro; Shimaoka, Hideki; Okada, Hiroki; Nakashima, Ryo; Beppu, Richiko; Kato, Daisuke; Sasaki, Takamitsu; Hoshino, Seiichiro; Nimura, Satoshi; Yamaura, Ken; Yamashita, Yuichi

    2016-01-01

    AIM: To evaluate the efficacy and safety of endoscopic submucosal dissection (ESD) under general anesthesia. METHODS: From January 2011 to July 2014, 206 consecutive patients had undergone ESD under general anesthesia for neoplasms of the stomach, esophagus, and colorectum were enrolled in this retrospective study. The efficacy and safety of ESD under general anesthesia were assessed. RESULTS: The en bloc resection rate of esophageal, gastric, and colorectal lesions was 100.0%, 98.3%, and 96.1%, respectively. The complication rate of perforation and bleeding were 0.0% and 0.0% in esophageal ESD, 1.7% and 1.7% in gastric ESD, and 3.9% and 2.0% in colorectal ESD, respectively. No cases of aspiration pneumonia were observed. All complications were managed by conservative treatment, with no surgical intervention required. CONCLUSION: With the cooperation of an anesthesiologist, ESD under general anesthesia appears to be a useful method, decreasing the risk of complications. PMID:27433293

  15. Safety climate in English general practices: workload pressures may compromise safety

    PubMed Central

    Reeves, David; Marsden, Kate; Avery, Anthony

    2015-01-01

    Abstract Objectives Although most health care interactions in the developed world occur in general practice, most of the literature on patient safety has focused on secondary care services. To address this issue, we have constructed a patient safety toolkit for English general practices. We report how practice and respondent characteristics affect scores on our safety climate measure, the PC‐Safequest, and address recent concerns with high levels of workload in English general practices. Methods We administered the PC‐Safequest, a 30‐item tool that was designed to measure safety climate in primary care practices, to 335 primary care staff members in 31 practices in England. Practice characteristics, such as list size and deprivation in the area the practice served, and respondent characteristics, such as whether the respondent was a manager, were also collected and used in a multilevel analysis to predict PC‐Safequest scores. Results Managers gave their practices significantly higher safety climate scores than did non‐managers. Respondents with more years of experience had a more negative perception of the level of workload in their practice. Practices with more registered patients and in areas of higher deprivation provided lower safety climate scores. Conclusions Managers rated their practices more positively on our safety climate measure, so the differences between the perceptions of managers and other staff may need to be reduced in order to build a strong safety culture. Excessive workload for more experienced staff and lower safety climate scores for larger practices may reflect ‘burnout’. Concerns that pressures in primary care could affect patient safety are discussed. PMID:26278127

  16. Chapter A9. Safety in Field Activities

    USGS Publications Warehouse

    Lane, Susan L.; Ray, Ronald G.

    1998-01-01

    The National Field Manual for the Collection of Water-Quality Data (National Field Manual) describes protocols (requirements and recommendations) and provides guidelines for U.S. Geological Survey (USGS) personnel who collect data used to assess the quality of the Nation's surface-water and ground-water resources. This chapter of the manual addresses topics related to personal safety to be used in the collection of water-quality data, including: policies and general regulations on field safety; transportation of people and equipment; implementation of surface-water and ground-water activities; procedures for handling chemicals; and information on potentially hazardous environmental conditions, animals, and plants. Each chapter of the National Field Manual is published separately and revised periodically. Newly published and revised chapters will be announced on the USGS Home Page on the World Wide Web under 'New Publications of the U.S. Geological Survey.' The URL for this page is http://pubs.usgs.gov/publications/ index.html.

  17. Safety and Environmental Activities for ITER

    NASA Astrophysics Data System (ADS)

    Saji, G.; Aymar, R.; Bartels, H.-W.; Gordon, C. W.; Gulden, W.; Holl, D. H.; Iida, H.; Inabe, T.; Iseli, M.; Kashirski, A. V.; Kolbasov, B. N.; Krivosheev, M.; McCarthy, K. A.; Marbach, G.; Morozov, S. I.; Natalizio, A.; Petti, D. A.; Piet, S. J.; Poucet, A. E.; Raeder, J.; Seki, Y.; Topilski, L. N.

    1997-09-01

    This paper will summarize highlights of the safety approach and discuss the ITER EDA safety activities. The ITER safety approach is driven by three major objectives: (1) Enhancement or improvement of fusion's intrinsic safety characteristics to the maximum extent feasible, which includes a minimization of the dependence on dedicated “safety systems”; (2) Selection of conservative design parameters and development of a robust design to accommodate uncertainties in plasma physics as well as the lack of operational experience and data; and (3) Integration of engineered mitigation systems to enhance the safety assurance against potentially hazardous inventories in the device by deploying well-established “nuclear safety” approaches and methodologies tailored as appropriate for ITER.

  18. [General coordination of hospital activity].

    PubMed

    Rodríguez, Paz; Serra, José Antonio

    2005-03-01

    The present article describes the organizational and general coordination measures taken by the hospital management to attend the 325 victims who arrived at our hospital after the terrorist attack on the morning of 11 March. Firstly, we summarize the activity performed by the extra-hospital emergency services and the distribution of the victims in centers. Secondly, we describe in greater detail the interventions performed to initiate the External Emergency Action Plan in our hospital, the triage system and identification of patients who used it, as well as the resources in terms of beds, operating rooms and personnel that were used on that day. Lastly, by way of discussion, we provide a critical analysis of our interventions. PMID:15771833

  19. General aviation crash safety program at Langley Research Center

    NASA Technical Reports Server (NTRS)

    Thomson, R. G.

    1976-01-01

    The purpose of the crash safety program is to support development of the technology to define and demonstrate new structural concepts for improved crash safety and occupant survivability in general aviation aircraft. The program involves three basic areas of research: full-scale crash simulation testing, nonlinear structural analyses necessary to predict failure modes and collapse mechanisms of the vehicle, and evaluation of energy absorption concepts for specific component design. Both analytical and experimental methods are being used to develop expertise in these areas. Analyses include both simplified procedures for estimating energy absorption capabilities and more complex computer programs for analysis of general airframe response. Full-scale tests of typical structures as well as tests on structural components are being used to verify the analyses and to demonstrate improved design concepts.

  20. Communicating vaccine safety to the media and general public.

    PubMed

    Oubari, Hiba; Tuttle, Ryan; Rath, Barbara; Bravo, Lulu

    2015-01-01

    Vaccines are among the most effective measures to control and prevent infectious diseases. Yet, the topic of vaccination is difficult to communicate, as it bears upon individual versus common good. The efficacy and safety of vaccines can only be shown by the absence of undesired events, such as vaccine-preventable diseases or adverse events following immunization. The authors of this paper view accurate, transparent and timely vaccine-safety communication to the media and general public as a core responsibility of healthcare providers. The authors wish to explore potential difficulties faced by immunization specialists when talking to the media, and suggest how to successfully convey vaccination messages to the general public. PMID:25859680

  1. 75 FR 4610 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-28

    ... Hazardous Materials Safety Administration (PHMSA) published a notice in the Federal Register (74 FR 61403... Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration. ACTION: Notice and request for...

  2. Safety Oversight of Decommissioning Activities at DOE Nuclear Sites

    SciTech Connect

    Zull, Lawrence M.; Yeniscavich, William

    2008-01-15

    The Defense Nuclear Facilities Safety Board (Board) is an independent federal agency established by Congress in 1988 to provide nuclear safety oversight of activities at U.S. Department of Energy (DOE) defense nuclear facilities. The activities under the Board's jurisdiction include the design, construction, startup, operation, and decommissioning of defense nuclear facilities at DOE sites. This paper reviews the Board's safety oversight of decommissioning activities at DOE sites, identifies the safety problems observed, and discusses Board initiatives to improve the safety of decommissioning activities at DOE sites. The decommissioning of former defense nuclear facilities has reduced the risk of radioactive material contamination and exposure to the public and site workers. In general, efforts to perform decommissioning work at DOE defense nuclear sites have been successful, and contractors performing decommissioning work have a good safety record. Decommissioning activities have recently been completed at sites identified for closure, including the Rocky Flats Environmental Technology Site, the Fernald Closure Project, and the Miamisburg Closure Project (the Mound site). The Rocky Flats and Fernald sites, which produced plutonium parts and uranium materials for defense needs (respectively), have been turned into wildlife refuges. The Mound site, which performed R and D activities on nuclear materials, has been converted into an industrial and technology park called the Mound Advanced Technology Center. The DOE Office of Legacy Management is responsible for the long term stewardship of these former EM sites. The Board has reviewed many decommissioning activities, and noted that there are valuable lessons learned that can benefit both DOE and the contractor. As part of its ongoing safety oversight responsibilities, the Board and its staff will continue to review the safety of DOE and contractor decommissioning activities at DOE defense nuclear sites.

  3. Active transportation safety features around schools in Canada.

    PubMed

    Pinkerton, Bryn; Rosu, Andrei; Janssen, Ian; Pickett, William

    2013-11-01

    The purpose of this study was to describe the presence and quality of active transportation safety features in Canadian school environments that relate to pedestrian and bicycle safety. Variations in these features and associated traffic concerns as perceived by school administrators were examined by geographic status and school type. The study was based on schools that participated in 2009/2010 Health Behaviour in School-aged Children (HBSC) survey. ArcGIS software version 10 and Google Earth were used to assess the presence and quality of ten different active transportation safety features. Findings suggest that there are crosswalks and good sidewalk coverage in the environments surrounding most Canadian schools, but a dearth of bicycle lanes and other traffic calming measures (e.g., speed bumps, traffic chokers). Significant urban/rural inequities exist with a greater prevalence of sidewalk coverage, crosswalks, traffic medians, and speed bumps in urban areas. With the exception of bicycle lanes, the active transportation safety features that were present were generally rated as high quality. Traffic was more of a concern to administrators in urban areas. This study provides novel information about active transportation safety features in Canadian school environments. This information could help guide public health efforts aimed at increasing active transportation levels while simultaneously decreasing active transportation injuries. PMID:24185844

  4. 10 CFR Appendix A to Subpart B of... - General Statement of Safety Basis Policy

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false General Statement of Safety Basis Policy A Appendix A to Subpart B of Part 830 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements Pt. 830, Subpt. B, App. A Appendix A to Subpart B of Part 830—General Statement of Safety Basis Policy A. Introduction This appendix describes...

  5. 10 CFR Appendix A to Subpart B of... - General Statement of Safety Basis Policy

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false General Statement of Safety Basis Policy A Appendix A to Subpart B of Part 830 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements Pt. 830, Subpt. B, App. A Appendix A to Subpart B of Part 830—General Statement of Safety Basis Policy A. Introduction This appendix describes...

  6. 77 FR 33777 - General Aviation Safety Forum: Climbing to the Next Level

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-07

    ... From the Federal Register Online via the Government Publishing Office ] NATIONAL TRANSPORTATION SAFETY BOARD General Aviation Safety Forum: Climbing to the Next Level The National Transportation Safety Board (NTSB) will convene a 2- day forum focused on safety issues related to general aviation on June 19-20, 2012 in Washington, DC. The event,...

  7. 21 CFR 610.11a - Inactivated influenza vaccine, general safety test.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Inactivated influenza vaccine, general safety test... Inactivated influenza vaccine, general safety test. For inactivated influenza vaccine, the general safety test... subcutaneous or intraperitoneal injection of 5.0 milliliters of inactivated influenza vaccine into each...

  8. 21 CFR 610.11a - Inactivated influenza vaccine, general safety test.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Inactivated influenza vaccine, general safety test... Inactivated influenza vaccine, general safety test. For inactivated influenza vaccine, the general safety test... subcutaneous or intraperitoneal injection of 5.0 milliliters of inactivated influenza vaccine into each...

  9. 21 CFR 610.11a - Inactivated influenza vaccine, general safety test.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Inactivated influenza vaccine, general safety test... Inactivated influenza vaccine, general safety test. For inactivated influenza vaccine, the general safety test... subcutaneous or intraperitoneal injection of 5.0 milliliters of inactivated influenza vaccine into each...

  10. 21 CFR 610.11a - Inactivated influenza vaccine, general safety test.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Inactivated influenza vaccine, general safety test... Inactivated influenza vaccine, general safety test. For inactivated influenza vaccine, the general safety test... subcutaneous or intraperitoneal injection of 5.0 milliliters of inactivated influenza vaccine into each...

  11. 21 CFR 610.11a - Inactivated influenza vaccine, general safety test.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Inactivated influenza vaccine, general safety test... Inactivated influenza vaccine, general safety test. For inactivated influenza vaccine, the general safety test... subcutaneous or intraperitoneal injection of 5.0 milliliters of inactivated influenza vaccine into each...

  12. 78 FR 57455 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-18

    ... June 14, 2013, (78 FR 36016). PHMSA received one comment in response to that notice. PHMSA is... Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice and...

  13. 77 FR 58622 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-21

    ... comments on this information collection was published on July 5, 2012 (77 FR 39797). No comments were... Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice and...

  14. 77 FR 74275 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-13

    ... following information collections was published on August 27, 2012, (77 FR 51848) under docket number PHMSA... Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice and...

  15. 76 FR 65778 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-24

    ..., PHMSA published a notice with request for comments in the Federal Register (76 FR 45904). The notice... Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice and...

  16. 78 FR 55775 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-11

    ... 23, 2013, (78 FR 23972). PHMSA received one comment in response to that notice. PHMSA is publishing... Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice and...

  17. 77 FR 15453 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-15

    ..., PHMSA published a notice with request for comments in the Federal Register (76 FR 81013). The notice... Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice and...

  18. 49 CFR 659.17 - System safety program plan: general requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false System safety program plan: general requirements... Role of the State Oversight Agency § 659.17 System safety program plan: general requirements. (a) The...) The oversight agency shall review and approve the rail transit agency system safety program plan....

  19. 49 CFR 659.17 - System safety program plan: general requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false System safety program plan: general requirements... Role of the State Oversight Agency § 659.17 System safety program plan: general requirements. (a) The...) The oversight agency shall review and approve the rail transit agency system safety program plan....

  20. 49 CFR 214.303 - Railroad on-track safety programs, generally.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Railroad on-track safety programs, generally. 214... RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.303 Railroad on-track safety programs, generally. (a) Each railroad to which this part...

  1. 49 CFR 214.303 - Railroad on-track safety programs, generally.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Railroad on-track safety programs, generally. 214... RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.303 Railroad on-track safety programs, generally. (a) Each railroad to which this part...

  2. 49 CFR 214.303 - Railroad on-track safety programs, generally.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Railroad on-track safety programs, generally. 214... RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.303 Railroad on-track safety programs, generally. (a) Each railroad to which this part...

  3. 49 CFR 214.303 - Railroad on-track safety programs, generally.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Railroad on-track safety programs, generally. 214... RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.303 Railroad on-track safety programs, generally. (a) Each railroad to which this part...

  4. 49 CFR 214.303 - Railroad on-track safety programs, generally.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Railroad on-track safety programs, generally. 214... RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.303 Railroad on-track safety programs, generally. (a) Each railroad to which this part...

  5. 49 CFR 214.317 - On-track safety procedures, generally.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false On-track safety procedures, generally. 214.317... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.317 On-track safety procedures, generally. Each employer subject to the provisions of this part shall...

  6. 49 CFR 214.317 - On-track safety procedures, generally.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false On-track safety procedures, generally. 214.317... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.317 On-track safety procedures, generally. Each employer subject to the provisions of this part shall...

  7. 49 CFR 214.317 - On-track safety procedures, generally.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false On-track safety procedures, generally. 214.317... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.317 On-track safety procedures, generally. Each employer subject to the provisions of this part shall...

  8. 49 CFR 214.317 - On-track safety procedures, generally.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false On-track safety procedures, generally. 214.317... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.317 On-track safety procedures, generally. Each employer subject to the provisions of this part shall...

  9. General Safety. Pre-Apprenticeship Phase 1 Training.

    ERIC Educational Resources Information Center

    Lane Community Coll., Eugene, OR.

    This self-paced student training module on safety is one of a number of modules developed for Pre-apprenticeship Phase 1 Training. Purpose of the module is to teach students the importance of becoming aware of safety, including causes of accidents, unsafe acts, and safety planning. The module may contain some or all of the following: a cover sheet…

  10. 33 CFR 88.12 - Public safety activities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Public safety activities. 88.12... NAVIGATION RULES ANNEX V: PILOT RULES § 88.12 Public safety activities. (a) Vessels engaged in government sanctioned public safety activities, and commercial vessels performing similar functions, may display...

  11. 33 CFR 88.12 - Public safety activities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Public safety activities. 88.12... NAVIGATION RULES ANNEX V: PILOT RULES § 88.12 Public safety activities. (a) Vessels engaged in government sanctioned public safety activities, and commercial vessels performing similar functions, may display...

  12. 33 CFR 88.12 - Public safety activities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Public safety activities. 88.12... NAVIGATION RULES ANNEX V: PILOT RULES § 88.12 Public safety activities. (a) Vessels engaged in government sanctioned public safety activities, and commercial vessels performing similar functions, may display...

  13. 33 CFR 88.12 - Public safety activities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Public safety activities. 88.12... NAVIGATION RULES ANNEX V: PILOT RULES § 88.12 Public safety activities. (a) Vessels engaged in government sanctioned public safety activities, and commercial vessels performing similar functions, may display...

  14. 33 CFR 88.12 - Public safety activities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Public safety activities. 88.12... NAVIGATION RULES ANNEX V: PILOT RULES § 88.12 Public safety activities. (a) Vessels engaged in government sanctioned public safety activities, and commercial vessels performing similar functions, may display...

  15. 21 CFR 601.32 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... SERVICES (CONTINUED) BIOLOGICS LICENSING Diagnostic Radiopharmaceuticals § 601.32 General factors relevant to safety and effectiveness. FDA's determination of the safety and effectiveness of a diagnostic radiopharmaceutical includes consideration of the following: (a) The proposed use of the...

  16. 21 CFR 601.32 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... SERVICES (CONTINUED) BIOLOGICS LICENSING Diagnostic Radiopharmaceuticals § 601.32 General factors relevant to safety and effectiveness. FDA's determination of the safety and effectiveness of a diagnostic radiopharmaceutical includes consideration of the following: (a) The proposed use of the...

  17. 21 CFR 601.32 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... SERVICES (CONTINUED) BIOLOGICS LICENSING Diagnostic Radiopharmaceuticals § 601.32 General factors relevant to safety and effectiveness. FDA's determination of the safety and effectiveness of a diagnostic radiopharmaceutical includes consideration of the following: (a) The proposed use of the...

  18. Potential risk of using General Estimates System: bicycle safety.

    PubMed

    Kweon, Young-Jun; Lee, Joyoung

    2010-11-01

    Beneficial effects of bicycle helmet use have been reported mostly based on medical or survey data collected from hospitals. This study was to examine the validity of the United States General Estimates System (GES) database familiar to many transportation professionals for a beneficial effect of helmet use in reducing the severity of injury to bicyclists and found potential risk of erroneous conclusions that can be drawn by a narrowly focused study when the GES database is used. Although the focus of the study was on bicycle helmet use, its findings regarding potential risk might be true for any type of traffic safety study using the GES data. A partial proportional odds model reflecting intrinsic ordering of injury severity was mainly used. About 16,000 bicycle-involved traffic crash records occurring in 2003 through 2008 in the United States were extracted from the GES database. Using the 2003-2008 GES data, a beneficial effect of helmet use was found in 2007, yet a detrimental effect in 2004 and no effect in 2003, 2005, 2006, and 2008, which are contrary to the past findings from medical or hospital survey data. It was speculated that these mixed results might be attributable to a possible lack of representation of the GES data for bicycle-involved traffic crashes, which may be supported by the findings, such as the average helmet use rates at the time of the crashes varying from 12% in 2004 to 38% in 2008. This suggests that the GES data may not be a reliable source for studying narrowly focused issues such as the effect of helmet use. A considerable fluctuation over years in basic statistical values (e.g., average) of variables of interest (e.g., helmet use) may be an indication of a possible lack of representation of the GES data. In such a case, caution should be exercised in interpreting and generalizing analysis results. PMID:20728621

  19. Visual Templates in Pattern Generalization Activity

    ERIC Educational Resources Information Center

    Rivera, F. D.

    2010-01-01

    In this research article, I present evidence of the existence of visual templates in pattern generalization activity. Such templates initially emerged from a 3-week design-driven classroom teaching experiment on pattern generalization involving linear figural patterns and were assessed for existence in a clinical interview that was conducted four…

  20. 24 CFR 1006.220 - Crime prevention and safety activities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Crime prevention and safety activities. 1006.220 Section 1006.220 Housing and Urban Development Regulations Relating to Housing and Urban... prevention and safety activities. NHHBG funds may be used for the provision of safety, security, and...

  1. Active gated imaging for automotive safety applications

    NASA Astrophysics Data System (ADS)

    Grauer, Yoav; Sonn, Ezri

    2015-03-01

    The paper presents the Active Gated Imaging System (AGIS), in relation to the automotive field. AGIS is based on a fast gated-camera equipped with a unique Gated-CMOS sensor, and a pulsed Illuminator, synchronized in the time domain to record images of a certain range of interest which are then processed by computer vision real-time algorithms. In recent years we have learned the system parameters which are most beneficial to night-time driving in terms of; field of view, illumination profile, resolution and processing power. AGIS provides also day-time imaging with additional capabilities, which enhances computer vision safety applications. AGIS provides an excellent candidate for camera-based Advanced Driver Assistance Systems (ADAS) and the path for autonomous driving, in the future, based on its outstanding low/high light-level, harsh weather conditions capabilities and 3D potential growth capabilities.

  2. 21 CFR 315.3 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 5 2014-04-01 2014-04-01 false General factors relevant to safety and effectiveness. 315.3 Section 315.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE DIAGNOSTIC RADIOPHARMACEUTICALS § 315.3 General factors relevant to safety and effectiveness....

  3. Efficacy and Safety of FospropofolFD Compared to Propofol When Given During the Induction of General Anaesthesia: A Phase II, Multi-centre, Randomized, Parallel-Group, Active-Controlled, Double-Blind, Double-Dummy Study.

    PubMed

    Liu, Rong; Luo, Chaozhi; Liu, Jin; Zhang, Wensheng; Li, Yan; Xu, Jing

    2016-07-01

    The present phase II study aimed to compare the efficacy and safety of fospropofol disodium for injection (FospropofolFD ) and propofol when given during the induction of general anaesthesia in patients scheduled for elective surgery. FospropofolFD is a water-soluble prodrug of propofol. Approved by the Ethical Committee, 240 participants aged 18-65 years were equally randomly allocated to receive an intravenous bolus of FospropofolFD 20 mg/kg or propofol 2 mg/kg without any anaesthetic pre-treatment. The primary efficacy end-point was the sedation success rate within 5 min. after administering investigational drugs (the sedation success is defined as obtaining Modified Observer's Assessment of Alertness/Sedation scale score of 1). All the participants completed the induction and intubation within 25 min. after administration. The sedation success rates within 5 min. after administration of FospropofolFD 20 mg/kg and propofol 2 mg/kg were 94.50% versus 100% in the intention-to-treat population and 95.10% versus 100% in the per-protocol population, respectively. The non-inferiority test obtained a p-value less than 0.025, and the lower limits of the one-sided 97.5% confidence interval were more than -0.09. This meant that FospropofolFD 20 mg/kg was considered non-inferior to propofol 2 mg/kg for the primary efficacy end-point. Compared with propofol 2 mg/kg, FospropofolFD 20 mg/kg had a slower sedation efficacy. No serious adverse events were observed in the two groups. The sedation success rate within 5 min. after administration of FospropofolFD 20 mg/kg was non-inferior to propofol 2 mg/kg, and FospropofolFD 20 mg/kg can be used for the induction of general anaesthesia safely. PMID:26781338

  4. 78 FR 36016 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477) or visit... Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice and...

  5. 75 FR 40863 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-14

    ... April 11, 2000 (65 FR 19477) or visit http://www.regulations.gov before submitting any such comments... Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice and...

  6. 77 FR 27279 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-09

    ... Privacy Act Statement in the Federal Register published on April 11, 2000, (65 FR 19477) or visit http... TRANSPORTATION Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice...

  7. 76 FR 50539 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-15

    ... notice with request for comments in the Federal Register on June 9, 2011 (76 FR 33808) on an information... TRANSPORTATION Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice...

  8. 77 FR 51848 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... April 11, 2000 (65 FR 19477) or visit http://www.regulations.gov before submitting any such comments... Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice and...

  9. 75 FR 76077 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477) or visit... Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice and...

  10. 75 FR 53733 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ... Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477) or visit http... TRANSPORTATION Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice...

  11. 49 CFR 238.229 - Safety appliances-general.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... section in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. You may obtain a copy of the incorporated... support meets all of the conditions contained in § 238.230(b)(1) for being considered part of the car body... disassembly of a car is necessary to visually inspect the involved safety appliance bracket or support,...

  12. 49 CFR 238.229 - Safety appliances-general.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... section in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. You may obtain a copy of the incorporated... support meets all of the conditions contained in § 238.230(b)(1) for being considered part of the car body... disassembly of a car is necessary to visually inspect the involved safety appliance bracket or support,...

  13. 49 CFR 238.229 - Safety appliances-general.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... section in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. You may obtain a copy of the incorporated... support meets all of the conditions contained in § 238.230(b)(1) for being considered part of the car body... disassembly of a car is necessary to visually inspect the involved safety appliance bracket or support,...

  14. 49 CFR 238.229 - Safety appliances-general.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... section in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. You may obtain a copy of the incorporated... support meets all of the conditions contained in § 238.230(b)(1) for being considered part of the car body... disassembly of a car is necessary to visually inspect the involved safety appliance bracket or support,...

  15. 49 CFR 238.229 - Safety appliances-general.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... section in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. You may obtain a copy of the incorporated... support meets all of the conditions contained in § 238.230(b)(1) for being considered part of the car body... disassembly of a car is necessary to visually inspect the involved safety appliance bracket or support,...

  16. General Consideration in the History, Physical Examination, and Safety Determination.

    PubMed

    Buchanan, Jonathan; Dexter, William; Powell, Amy; Wright, Justin

    2015-09-01

    A thorough medical history is perhaps the most important aspect when evaluating an athlete before wilderness adventure. A physical examination should follow focusing on conditions that may be affected by changes in atmospheric pressure, extremes of temperature, or altitude. This information can then be used to make safety recommendations ensuring that adventurers are able to safely enjoy participation in the wilderness pursuit of their choice. PMID:26340730

  17. General Consideration in the History, Physical Examination, and Safety Determination.

    PubMed

    Buchanan, Jonathan; Dexter, William; Powell, Amy; Wright, Justin

    2015-12-01

    A thorough medical history is perhaps the most important aspect when evaluating an athlete before wilderness adventure. A physical examination should follow focusing on conditions that may be affected by changes in atmospheric pressure, extremes of temperature, or altitude. This information can then be used to make safety recommendations ensuring that adventurers are able to safely enjoy participation in the wilderness pursuit of their choice. PMID:26617374

  18. Convoy Active Safety Technologies Warfighter Experiment I

    NASA Astrophysics Data System (ADS)

    Schoenherr, Edward; Theisen, Bernard L.; Animashaun, Asisat; Davis, James, Jr.; Day, Christopher

    2008-04-01

    The operational ability to project and sustain forces in distant, anti-access and area denial environments poses new challenges for combatant commanders. One of the new challenges is the ability to conduct sustainment operations at operationally feasible times and places on the battlefield. Combatant commanders require a sustainment system that is agile, versatile, and survivable throughout the range of military operations and across the spectrum of conflict. A key component of conducting responsive, operationally feasible sustainment operations is the ability to conduct sustainment convoys. Sustainment convoys are critical to providing combatant commanders the right support, at the right time and place, and in the right quantities, across the full range of military operations. The ability to conduct sustainment convoys in a variety of hostile environments require force protection measures that address the enemy threat and protect the Soldier. One cost effective, technically feasible method of increasing the force protection for sustainment convoys is the use of robotic follower technology and autonomous navigation. The Convoy Active Safety Technologies (CAST) system is a driver assist, convoy autopilot technology aimed to address these issues. Warfigher Experiment I, held at A.P. Hill, VA in the fall of 2007, tested the utility of this vehicle following technology not only in measures of system integrity and performance vs. manual driving, but also the physiological effects on the operators themselves. This paper will detail the Warfigher Experiment's methodology, analysis, results and conclusions.

  19. Lightning Safety and Outdoor Sports Activities

    MedlinePlus

    ... FORECAST Local Graphical Aviation Marine Rivers and Lakes Hurricanes Severe Weather Fire Weather Sun/Moon Long Range ... Safety Campaigns Air Quality Drought Floods Fog Heat Hurricanes Lightning Rip Currents Safe Boating Space Weather Tornadoes, ...

  20. Nursing activity in general intensive care.

    PubMed

    Harrison, Lynne; Nixon, Gillian

    2002-03-01

    1. In this cost-conscious climate there is a need to make explicit and justify the rationale to support direct patient contact by Registered Nurses. The current shortage of qualified nursing staff means that it is essential that experience and expertise be utilized to the benefit of patients and the service as a whole. 2. This study used a descriptive approach to describe, categorize and quantify the activities of nurses working in a six-bed general intensive care unit. 3. Data were collected using a self-reporting diary log sheet that identified the focus of an individual's activity at 5-minute intervals. All Registered Nurses, on all shifts over a 7-day period, completed log sheets. 4. The results demonstrate that nurses working in this general intensive care unit spent 85% of their time in activities associated with providing direct patient care. However, up to 6% of time was spent undertaking non-nursing duties, and analysis of unit activity provided data to support an increase in the establishment and review of the shift patterns of health care assistants. 5. The findings of the study indicate that nurses in charge of shifts spend 24.1% of their time in managerial and administrative activity; this reduces the amount of time spent in direct patient contact. PMID:11903715

  1. Consultations with general practitioners on patient safety measures based on routinely collected data in primary care

    PubMed Central

    Tsang, Carmen; Majeed, Azeem; Aylin, Paul

    2012-01-01

    Objectives To gauge the opinions of doctors working, or interested, in general practice on monitoring patient safety using administrative data. The findings will inform the development of routinely collected data-based patient safety indicators in general practice and elsewhere in primary care. Design Non-systematic participant recruitment, using personal contacts and colleagues’ recommendations. Setting Face-to-face consultations at participants’ places of work, between June 2010 and February 2011. Participants Four general practitioners (GPs) and a final year medical student. The four clinicians had between eight to 34 years of clinical practice experience, and held non-clinical positions in addition to their clinical roles. Main outcome measures Views on safety issues and improvement priorities, measurement methods, uses of administrative data, role of administrative data in patient safety and experiences of quality and safety initiatives. Results Medication and communication were the most commonly identified areas of patient safety concern. Perceived safety barriers included incident-reporting reluctance, inadequate medical education and low computer competency. Data access, financial constraints, policy changes and technology handicaps posed challenges to data use. Suggested safety improvements included better communication between providers and local partnerships between GPs. Conclusions The views of GPs and other primary care staff are pivotal to decisions on the future of English primary care and the health system. Broad views of general practice safety issues were shown, with possible reasons for patient harm and quality and safety improvement obstacles. There was general consensus on areas requiring urgent attention and strategies to enhance data use for safety monitoring. PMID:22461969

  2. 21 CFR 315.3 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... SERVICES (CONTINUED) DRUGS FOR HUMAN USE DIAGNOSTIC RADIOPHARMACEUTICALS § 315.3 General factors relevant to safety and effectiveness. FDA's determination of the safety and effectiveness of a diagnostic radiopharmaceutical includes consideration of the following: (a) The proposed use of the...

  3. 21 CFR 315.3 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... SERVICES (CONTINUED) DRUGS FOR HUMAN USE DIAGNOSTIC RADIOPHARMACEUTICALS § 315.3 General factors relevant to safety and effectiveness. FDA's determination of the safety and effectiveness of a diagnostic radiopharmaceutical includes consideration of the following: (a) The proposed use of the...

  4. ILO activities in the area of chemical safety.

    PubMed

    Obadia, Isaac

    2003-08-21

    The ILO has been active in the area of safety in the use of chemicals at work since the year of its creation in 1919, including the development of international treaties and other technical instruments, the provision of technical assistance to its member States, and the development of chemical safety information systems. The two key ILO standards in this area are the Conventions on safety in the use of chemicals at work (No. 170, 1990), and the Prevention of Major Industrial Accidents (No. 174, 1993). The ILO Programme on occupational safety, health and environment (Safe Work) is currently responsible for ILO chemical safety activities. In the past two decades, most of ILO work in this area has been carried out within the context of inter-agency collaboration frameworks linking the ILO, WHO, UNEP, FAO, UNIDO, UNITAR, and the OECD, including the International Programme on Chemical Safety (IPCS), the Inter-Organisation Programme for the Sound Management of Chemicals (IOMC), and the Intergovernmental Forum on Chemical Safety (IFCS). Apart from the regular development, updating and dissemination of chemical safety information data bases such as the IPCS International Chemical Cards, the elaboration of a Globally harmonized system for the classification and labelling of Chemicals (GHS) has been the most outstanding achievement of this international collaboration on chemical safety. PMID:12909402

  5. 21 CFR 315.3 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 5 2011-04-01 2011-04-01 false General factors relevant to safety and effectiveness. 315.3 Section 315.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE DIAGNOSTIC RADIOPHARMACEUTICALS § 315.3 General factors...

  6. 21 CFR 601.32 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false General factors relevant to safety and effectiveness. 601.32 Section 601.32 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS LICENSING Diagnostic Radiopharmaceuticals § 601.32 General factors...

  7. 21 CFR 315.3 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false General factors relevant to safety and effectiveness. 315.3 Section 315.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE DIAGNOSTIC RADIOPHARMACEUTICALS § 315.3 General factors...

  8. The Evaluation of the Safety Benefits of Combined Passive and On-Board Active Safety Applications

    PubMed Central

    Page, Yves; Cuny, Sophie; Zangmeister, Tobias; Kreiss, Jens-Peter; Hermitte, Thierry

    2009-01-01

    One of the objectives of the European TRACE project (TRaffic Accident Causation in Europe, 2006–2008) was to estimate the proportion of injury accidents that could be avoided and/or the proportion of injury accidents where the severity could be mitigated for on-the-market safety applications, if 100 % of the car fleet would be equipped with them. We have selected for evaluation the Electronic Stability Control (ESC) and the Emergency Brake Assist (EBA) applications. As for passive safety systems, recent cars are designed to offer overall safety protection. Car structure, load limiters, front airbags, side airbags, knee airbags, pretensioners, padding and non aggressive structures in the door panel, the dashboard, the windshield, the seats, and the head rest also contribute to applying more protection. The whole safety package is very difficult to evaluate separately, one element independently segmented from the others. We decided to consider evaluating the effectivenessof the whole passive safety package, This package,, for the sake of simplicity, was the number of stars awarded at the Euro NCAP testing. The challenges were to compare the effectiveness of some safety configuration SC I, with the effectiveness of a different safety configuration SC II. A safety configuration is understood as a package of safety functions. Ten comparisons have been carried out such as the evaluation of the safety benefit of a fifth star given that the car has four stars and an EBA. The main outcome of this analysis is that any addition of a passive or active safety function selected in this analysis is producing increased safety benefits. For example, if all cars were five stars fitted with EBA and ESC, instead of four stars without ESC and EBA, injury accidents would be reduced by 47.2% for severe injuries and 69.5% for fatal injuries. PMID:20184838

  9. The evaluation of the safety benefits of combined passive and on-board active safety applications.

    PubMed

    Page, Yves; Cuny, Sophie; Zangmeister, Tobias; Kreiss, Jens-Peter; Hermitte, Thierry

    2009-10-01

    One of the objectives of the European TRACE project (TRaffic Accident Causation in Europe, 2006-2008) was to estimate the proportion of injury accidents that could be avoided and/or the proportion of injury accidents where the severity could be mitigated for on-the-market safety applications, if 100 % of the car fleet would be equipped with them. We have selected for evaluation the Electronic Stability Control (ESC) and the Emergency Brake Assist (EBA) applications. As for passive safety systems, recent cars are designed to offer overall safety protection. Car structure, load limiters, front airbags, side airbags, knee airbags, pretensioners, padding and non aggressive structures in the door panel, the dashboard, the windshield, the seats, and the head rest also contribute to applying more protection. The whole safety package is very difficult to evaluate separately, one element independently segmented from the others. We decided to consider evaluating the effectiveness of the whole passive safety package, This package,, for the sake of simplicity, was the number of stars awarded at the Euro NCAP testing. The challenges were to compare the effectiveness of some safety configuration SC I, with the effectiveness of a different safety configuration SC II. A safety configuration is understood as a package of safety functions. Ten comparisons have been carried out such as the evaluation of the safety benefit of a fifth star given that the car has four stars and an EBA. The main outcome of this analysis is that any addition of a passive or active safety function selected in this analysis is producing increased safety benefits. For example, if all cars were five stars fitted with EBA and ESC, instead of four stars without ESC and EBA, injury accidents would be reduced by 47.2% for severe injuries and 69.5% for fatal injuries. PMID:20184838

  10. The Effect of Line Maintenance Activity on Airline Safety Quality

    NASA Technical Reports Server (NTRS)

    Rhoades, Dawna L.; Reynolds, Rosemarie; Waguespack, Blaise, Jr.; Williams, Michael

    2005-01-01

    One of the arguments against deregulation of the airline industry has been the possibility that financially troubled carriers would be tempted to lower line maintenance spending, thus lowering maintenance quality and decreasing the overall safety of the carrier. Given the financial crisis triggered by the events of 9/11: it appears to be a good time to revisit this issue. This paper examines the quality of airline line maintenance activity and examines the impact of maintenance spending on maintenance quality and overall safety. Findings indicate that increased maintenance spending is associated with increased line maintenance activity and increased overall safety quality for the major U.S. carriers.

  11. Methylphenidate Actively Induces Emergence from General Anesthesia

    PubMed Central

    Solt, Ken; Cotten, Joseph F.; Cimenser, Aylin; Wong, Kin F.K.; Chemali, Jessica J.; Brown, Emery N.

    2011-01-01

    Background Although accumulating evidence suggests that arousal pathways in the brain play important roles in emergence from general anesthesia, the roles of monoaminergic arousal circuits are unclear. In this study we tested the hypothesis that methylphenidate (an inhibitor of dopamine and norepinephrine transporters) induces emergence from isoflurane anesthesia. Methods Using adult rats we tested the effect of methylphenidate IV on time to emergence from isoflurane anesthesia. We then performed experiments to test separately for methylphenidate-induced changes in arousal and changes in minute ventilation. A dose-response study was performed to test for methylphenidate–induced restoration of righting during continuous isoflurane anesthesia. Surface electroencephalogram recordings were performed to observe neurophysiological changes. Plethysmography recordings and arterial blood gas analysis were performed to assess methylphenidate-induced changes in respiratory function. Droperidol IV was administered to test for inhibition of methylphenidate's actions. Results Methylphenidate decreased median time to emergence from 280 to 91 s. The median difference in time to emergence without compared to with methylphenidate was 200 [155, 331] s (median, [95% confidence interval]). During continuous inhalation of isoflurane, methylphenidate induced return of righting in a dose-dependent manner, induced a shift in electroencephalogram power from delta to theta, and induced an increase in minute ventilation. Administration of droperidol (0.5 mg/kg IV) prior to methylphenidate (5 mg/kg IV) largely inhibited methylphenidate-induced emergence behavior, electroencephalogram changes, and changes in minute ventilation. Conclusions Methylphenidate actively induces emergence from isoflurane anesthesia by increasing arousal and respiratory drive, possibly through activation of dopaminergic and adrenergic arousal circuits. Our findings suggest that methylphenidate may be clinically

  12. Playing It Smart: Safety in Extracurricular Activities

    ERIC Educational Resources Information Center

    Armenta, Tony

    2011-01-01

    An integral part of the school experience for many students is involvement in extracurricular activities such as athletics, cheerleading, band, and others. Likewise, cocurricular activities, such as field trips, provide a chance for students to connect off-campus experiences to the material learned in the classroom. These types of activities,…

  13. A general stochastic approach to unavailability analysis of standby safety systems

    SciTech Connect

    Van Der Weide, H.; Pandey, M. D.

    2013-07-01

    The paper presents a general analytical framework to analyze unavailability caused by latent failures in standby safety systems used in nuclear plants. The proposed approach is general in a sense that it encompasses a variety of inspection and maintenance policies and relaxes restrictive assumptions regarding the distributions of time to failure (or aging) and duration of repair. A key result of the paper is a general integral equation for point unavailability, which can be tailored to any specific maintenance policy. (authors)

  14. 78 FR 34703 - Pipeline Safety: Information Collection Activities, Revision to Gas Distribution Annual Report

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ... TRANSPORTATION Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection Activities, Revision to Gas Distribution Annual Report AGENCY: Pipeline and Hazardous Materials Safety... the Paperwork Reduction Act of 1995, the Pipeline and Hazardous Materials Safety Administration...

  15. Status of Safety& Environmental Activities for Inertial Fusion Energy

    SciTech Connect

    Latkowski, J F; Reyes, S; Cadwallader, L C; Sharpe, J P; Marshall, T D; Merrill, B J; Moore, R L; Petti, D A; Falquina, R; Rodriguez, A; Sanz, J; Cabellos, O

    2002-11-25

    Over the past several years, significant progress has been made in the analysis of safety and environmental (S&E) issues for inertial fusion energy (IFE). Detailed safety assessments have been performed for the baseline power plant concepts, as well as for a conceptual target fabrication facility. Safety analysis results are helping to drive the agenda for experiments. A survey of the S&E characteristics--both radiological and chemical--of candidate target materials has been completed. Accident initiating events have been identified and incorporated into master logic diagrams, which will be essential to the detailed safety analyses that will be needed in the future. Studies of aerosol generation and transport will have important safety implications. A Monte Carlo-based uncertainty analysis procedure has been developed for use in neutron activation calculations. Finally, waste management issues are receiving increased attention and are deserving of further discussion.

  16. Safety of evolutionary and innovative nuclear reactors: IAEA activities and world efforts

    SciTech Connect

    Saito, T.; Gasparini, M.

    2004-07-01

    'Defence in Depth' approach constitutes the basis of the IAEA safety standards for nuclear power plants. Lessons learned from the current generation of reactors suggest that, for the next generation of reactor designs, the Defence in Depth philosophy should be retained, and that its implementation should be guided by the probabilistic insights. Recent developments in the area of general safety requirements based on Defence in Depth approach are examined and summarized. Global efforts to harmonize safety requirements for evolutionary nuclear power plants have involved many countries and organizations such as IAEA, US EPRI and European Utility EUR Organization. In recent years, developments of innovative nuclear power plants are also being discussed. The IAEA is currently developing a safety approach specifically for innovative nuclear reactors. This approach will eventually lead to a proposal of safety requirements for innovative reactors. Such activities related to safety requirements of evolutionary and innovative reactors are introduced. Various evolutionary and innovative reactor designs are reported in the world. The safety design features of evolutionary large LWRs, innovative LWRs, Modular High Temperature Gas Reactors and Small Liquid Metal Cooled LMRs are also introduced. Enhanced safety features proposed in such reactors are discussed and summarized according to the levels of Defence in Depth. For future nuclear plants, international cooperation and harmonization, especially in the area of safety, appear to be inevitable. Based on the past experience with many member states, the IAEA believes itself to be the uniquely positioned international organization to play this key role. (authors)

  17. Support for the revocation of general safety test regulations in biologics license applications.

    PubMed

    Evans, Dana M; Thorn, Jennifer M; Arch-Douglas, Katherine; Sperry, Justin B; Thompson, Bruce; Davis, Heather L; McCluskie, Michael J

    2016-05-01

    The United States Food and Drug Administration recently removed the requirement for a General Safety Test (GST) for biologics in the Code of Federal Regulations (21 CFR 610.11). The GST, as well as abnormal toxicity (European Pharmacopeia) and innocuity tests (World Health Organization), were designed to test for extraneous toxic contaminants on each product lot intended for human use. Tests require one-week observations for general health and weight following injection of specified volumes of product batches into guinea pigs and mice. At the volumes specified, dose-related toxicity may result when the product is pharmacologically active in rodents. With vaccines, required doses may be > 3 logs higher than intended human dose on a weight-adjusted basis and if an immune modulatory adjuvant is included, systemic immune hyperactivation may cause toxicity. Herein, using the CpG/alum adjuvant combination we evaluated the different test protocols and showed their unsuitability for this adjuvant combination. PMID:26996102

  18. Activities of the PNC Nuclear Safety Working Group

    SciTech Connect

    Kato, W.Y.

    1991-12-31

    The Nuclear Safety Working Group of the Pacific Nuclear Council promotes nuclear safety cooperation among its members. Status of safety research, emergency planning, development of lists of technical experts, severe accident prevention and mitigation have been the topics of discussion in the NSWG. This paper reviews and compares the severe accident prevention and mitigation program activities in some of the areas of the Pacific Basin region based on papers presented at a special session organized by the NSWG at an ANS Topical Meeting as well as papers from other sources.

  19. Activities of the PNC Nuclear Safety Working Group

    SciTech Connect

    Kato, W.Y.

    1991-01-01

    The Nuclear Safety Working Group of the Pacific Nuclear Council promotes nuclear safety cooperation among its members. Status of safety research, emergency planning, development of lists of technical experts, severe accident prevention and mitigation have been the topics of discussion in the NSWG. This paper reviews and compares the severe accident prevention and mitigation program activities in some of the areas of the Pacific Basin region based on papers presented at a special session organized by the NSWG at an ANS Topical Meeting as well as papers from other sources.

  20. Effects of patient safety culture interventions on incident reporting in general practice: a cluster randomised trial

    PubMed Central

    Verbakel, Natasha J; Langelaan, Maaike; Verheij, Theo JM; Wagner, Cordula; Zwart, Dorien LM

    2015-01-01

    Background A constructive safety culture is essential for the successful implementation of patient safety improvements. Aim To assess the effect of two patient safety culture interventions on incident reporting as a proxy of safety culture. Design and setting A three-arm cluster randomised trial was conducted in a mixed method study, studying the effect of administering a patient safety culture questionnaire (intervention I), the questionnaire complemented with a practice-based workshop (intervention II) and no intervention (control) in 30 general practices in the Netherlands. Method The primary outcome, the number of reported incidents, was measured with a questionnaire at baseline and a year after. Analysis was performed using a negative binomial model. Secondary outcomes were quality and safety indicators and safety culture. Mixed effects linear regression was used to analyse the culture questionnaires. Results The number of incidents increased in both intervention groups, to 82 and 224 in intervention I and II respectively. Adjusted for baseline number of incidents, practice size and accreditation status, the study showed that practices that additionally participated in the workshop reported 42 (95% confidence interval [CI] = 9.81 to 177.50) times more incidents compared to the control group. Practices that only completed the questionnaire reported 5 (95% CI = 1.17 to 25.49) times more incidents. There were no statistically significant differences in staff perception of patient safety culture at follow-up between the three study groups. Conclusion Educating staff and facilitating discussion about patient safety culture in their own practice leads to increased reporting of incidents. It is beneficial to invest in a team-wise effort to improve patient safety. PMID:25918337

  1. 24 CFR 1006.220 - Crime prevention and safety activities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Crime prevention and safety... URBAN DEVELOPMENT NATIVE HAWAIIAN HOUSING BLOCK GRANT PROGRAM Eligible Activities § 1006.220 Crime... enforcement measures and activities appropriate to protect residents of affordable housing from...

  2. 24 CFR 1006.220 - Crime prevention and safety activities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false Crime prevention and safety... URBAN DEVELOPMENT NATIVE HAWAIIAN HOUSING BLOCK GRANT PROGRAM Eligible Activities § 1006.220 Crime... enforcement measures and activities appropriate to protect residents of affordable housing from...

  3. 24 CFR 1006.220 - Crime prevention and safety activities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false Crime prevention and safety... URBAN DEVELOPMENT NATIVE HAWAIIAN HOUSING BLOCK GRANT PROGRAM Eligible Activities § 1006.220 Crime... enforcement measures and activities appropriate to protect residents of affordable housing from...

  4. 24 CFR 1006.220 - Crime prevention and safety activities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Crime prevention and safety... URBAN DEVELOPMENT NATIVE HAWAIIAN HOUSING BLOCK GRANT PROGRAM Eligible Activities § 1006.220 Crime... enforcement measures and activities appropriate to protect residents of affordable housing from...

  5. Preliminary reentry safety assessment of the General Purpose Heat Source module for the Cassini mission: Aerospace Nuclear Safety Program

    SciTech Connect

    Conn, D.W.; Brenza, P.T.

    1993-04-01

    As asked by the U. S. Department of Energy/Office of Special Applications, and in support of the Environmental Impact Statement for the Cassini mission, The Johns Hopkins University/Applied Physics Laboratory (JHU/APL) has conducted preliminary one-dimensional ablation and thermal analyses of the General Purpose Heat Source (GPHS). The predicted earth entry conditions provided by the Jet Propulsion Laboratory (JPL) for a Cassini Venus-Venus-Earth-Jupiter Gravity Assist (VVEJGA) trajectory were used as initial conditions. The results of this study which constitute the initial reentry analysis assessment leading to the Cassini Updated Safety, Analysis Report (USAR) are discussed in this document.

  6. Preliminary reentry safety assessment of the General Purpose Heat Source module for the Cassini mission: Aerospace Nuclear Safety Program

    NASA Astrophysics Data System (ADS)

    Conn, D. W.; Brenza, P. T.

    1993-04-01

    As asked by the U.S. Department of Energy/Office of Special Applications, and in support of the Environmental Impact Statement for the Cassini mission, The Johns Hopkins University/Applied Physics Laboratory (JHU/APL) has conducted preliminary one dimensional ablation and thermal analyses of the General Purpose Heat Source (GPHS). The predicted earth entry conditions provided by the Jet Propulsion Laboratory (JPL) for a Cassini Venus - Venus - Earth - Jupiter gravity assist (VVEJGA) trajectory were used as initial conditions. The results of this study, which constitute the initial reentry analysis assessment leading to the Cassini Updated Safety Analysis Report (USAR), are discussed in this document.

  7. 21 CFR 601.32 - General factors relevant to safety and effectiveness.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true General factors relevant to safety and effectiveness. 601.32 Section 601.32 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... estimated absorbed radiation dose of the diagnostic radiopharmaceutical....

  8. 21 CFR 570.20 - General principles for evaluating the safety of food additives.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 6 2013-04-01 2013-04-01 false General principles for evaluating the safety of food additives. 570.20 Section 570.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS FOOD ADDITIVES Food...

  9. General safety basis development guidance for environmental restoration decontamination and decommissioning

    SciTech Connect

    Ellingson, D.R.; Kerr, N.; Bohlander, K.; Hansen, J.; Crowley, W.

    1994-02-01

    Safety analyses have the objective of contributing to two essential ingredients of a successful operation. The first is promoting the safety of the operation through worker involvement in information development (safety basis). The second is obtaining approval to conduct the operation (authorization). Typically these ingredients are assembled under separate programs covered by separate DOE requirements. DOE authorization relies on successful development of a document containing up to 21 topics written in terms and language suited to reviewers and approvers. Safety relies on successful training and procedures that convert the technical documented information into terms and language understandable to the worker. This separation can lead to successful incorporation of one ingredient independent of the other. At best, this separation may result in a safe but unauthorized operation; at worst, the separation may result in an unsafe operation authorized to proceed. This guide is based on experiences gained by contractors who have integrated rather than separated the safety and authorization. The short duration of ER/D&D activities, the uncertainties of hazards, and the publicly expressed desire for demonstrable progress in cleanup activities add emphasis to the need to integrate rather than separate and develop new programs. Experience-based information has been useful to workers, safety analysis practitioners, and reviewers in the following ways: (1) Acquiring or developing the needed information in a useful form; (2) Managing the uncertainties during activity development and operation; (3) Identifying the subset of applicable requirements for an activity; (4) Developing the appropriate level of documentation detail for a specific activity; and (5) Increasing the usefulness and use of safety analysis (ownership).

  10. Safety in Outdoor Recreational Activities. Sports Safety Series, Monograph No. 6.

    ERIC Educational Resources Information Center

    Borozne, Joseph, Ed.; And Others

    Safety procedures are outlined for the following sports: (1) fishing; (2) hunting and shooting; (3) skeet and trap; (4) hiking and mountaineering; (5) ice fishing; (6) ice skating; (7) skiing; (8) snowmobiling; (9) recreational motorcycling; and (10) developmental and play activities. (JD)

  11. Oral Radiology Safety Standards Adopted by the General Dentists Practicing in National Capital Region (NCR)

    PubMed Central

    Jayaprakash, K.; Shivalingesh, K.K.; Agarwal, Vartika; Gupta, Bhuvandeep; Anand, Richa; Sharma, Abhinav; Kushwaha, Sumedha

    2016-01-01

    Introduction With advancement in diagnostic techniques, the utilization of radiologic examination has risen to many folds in the last two decades. Ionizing radiations from the radiographic examination carry the potential for harm by inducing carcino-genesis in addition to the diagnostic information extracted. Radiation doses utilized in the course of dental treatment might be low for individual examinations but patients are exposed to repeated examinations very often and many people are exposed during the course of dental care. Therefore, principles of radiation protection and safety are necessary for the dentists to follow to ensure minimum and inevitable exposure. Aim The aim of this study was to investigate the knowledge and behaviour of general dentists practicing in the National Capital Region (NCR) regarding radiation safety during oral radiographic procedures. Materials and Methods The study was a questionnaire based cross-sectional study. A total of 500 general dentists were contacted to participate in the study. The target population entailed of general dentists practicing in the National Capital Region. Data was computed and tabulated in Microsoft excel sheet and statistical analysis was performed with the help of SPSS version 21.0. Results The total response rate recovered was 70.6% and the respondents comprised of 59% and 41% males & females respectively. Only 64.8% of the general dentists contemplated thyroid to be the most important organ for radiation protection. Only 28.8% of the general dentists followed the position & distance rule appropriately. Conclusion The results showed that the knowledge and behaviour of the general dentists and the practices adopted by them regarding radiation safety is not satisfactory. To ensure the following of basic and necessary guidelines for radiation safety and protection, strict rules with penalties should be implemented by the state councils and new and interesting methods of education for this spectrum of the

  12. GPHS (General Purpose Heat Source) uranium oxide encapsulations supporting satellite safety tests

    SciTech Connect

    Kanne, W.R.

    1989-04-24

    General Purpose Heat Source (GPHS) simulant-fueled capsules were assembled, welded, nondestructively examined, and shipped to Los Alamos National Laboratory (LANL) for satellite safety tests. Simulant-fueled iridium capsules contain depleted uranium oxide pellets that serve as a stand-in for plutonium-238 oxide pellets. Information on forty seven capsules prepared during 1987 and 1988 is recorded in this memorandum along with a description of the processes used for encapsulation and evaluation. LANL expects to use all capsules for destructive safety tests, which are under way. Test results so far have demonstrated excellent integrity of the Savannah River capsule welds. 10 refs., 5 figs., 3 tabs.

  13. 10 CFR 810.7 - Generally authorized activities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Generally authorized activities. 810.7 Section 810.7 Energy DEPARTMENT OF ENERGY ASSISTANCE TO FOREIGN ATOMIC ENERGY ACTIVITIES § 810.7 Generally authorized activities. In accordance with section 57b(2) of the Atomic Energy Act, the Secretary of Energy has determined that the following activities...

  14. 24 CFR 92.205 - Eligible activities: General.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Eligible activities: General. 92... Activities § 92.205 Eligible activities: General. (a) Eligible activities. (1) HOME funds may be used by a... a reasonable minimum balance. While loan funds guaranteed with HOME funds are subject to all...

  15. 24 CFR 92.205 - Eligible activities: General.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Eligible activities: General. 92... Activities § 92.205 Eligible activities: General. (a) Eligible activities. (1) HOME funds may be used by a... a reasonable minimum balance. While loan funds guaranteed with HOME funds are subject to all...

  16. 10 CFR 810.7 - Generally authorized activities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Generally authorized activities. 810.7 Section 810.7 Energy DEPARTMENT OF ENERGY ASSISTANCE TO FOREIGN ATOMIC ENERGY ACTIVITIES § 810.7 Generally authorized activities. In accordance with section 57b(2) of the Atomic Energy Act, the Secretary of Energy has determined that the following activities...

  17. The Frankfurt Patient Safety Climate Questionnaire for General Practices (FraSiK): analysis of psychometric properties.

    PubMed

    Hoffmann, Barbara; Domanska, Olga Maria; Albay, Zeycan; Mueller, Vera; Guethlin, Corina; Thomas, Eric J; Gerlach, Ferdinand M

    2011-09-01

    BACKGROUND Safety culture has been identified as having a major impact on how safety is managed in healthcare. However, it has not received much attention in general practices. Hence, no instrument yet exists to assess safety climate-the measurable artefact of safety culture-in this setting. This study aims to evaluate psychometric properties of a newly developed safety climate questionnaire for use in German general practices. METHODS The existing Safety Attitudes Questionnaire, Ambulatory Version, was considerably modified and enhanced in order to be applicable in general practice. After pilot tests and its application in a random sample of 400 German practices, a first psychometric analysis led to modifications in several items. A further psychometric analysis was conducted with an additional sample of 60 practices and a response rate of 97.08%. Exploratory factor analysis with orthogonal varimax rotation was carried out and the internal consistency of the identified factors was calculated. RESULTS Nine factors emerged, representing a wide range of dimensions associated with safety culture: teamwork climate, error management, safety of clinical processes, perception of causes of errors, job satisfaction, safety of office structure, receptiveness to healthcare assistants and patients, staff perception of management, and quality and safety of medical care. Internal consistency of factors is moderate to good. CONCLUSIONS This study demonstrates the development of a patient safety climate instrument. The questionnaire displays established features of safety climate and additionally contains features that might be specific to small-scale general practices. PMID:21571753

  18. SAFETY ASPECTS OF OXYGEN AERATION ACTIVATED SLUDGE SYSTEMS

    EPA Science Inventory

    This project was carried out to assess the impact of the use of oxygen and oxygen-enriched air for aeration of activated sludge systems on the safety of municipal waste-water treatment plants and their personnel. The tasks included (1) determination of oxygen combustion hazards f...

  19. Safety from Crime and Physical Activity among Older Adults: A Population-Based Study in Brazil

    PubMed Central

    Weber Corseuil, Maruí; Hallal, Pedro Curi; Xavier Corseuil, Herton; Jayce Ceola Schneider, Ione; d'Orsi, Eleonora

    2012-01-01

    Objective. To evaluate the association between safety from crime and physical activity among older adults. Methods. A population-based survey including 1,656 older adults (60+ years) took place in Florianopolis, Brazil, in 2009-2010. Commuting and leisure time physical activity were assessed through the long version of the International Physical Activity Questionnaire. Perception of safety from crime was assessed using the Neighbourhood Environment Walkability Scale. Results. Perceiving the neighbourhood as safe during the day was related to a 25% increased likelihood of being active in leisure time (95% CI 1.02–1.53); general perception of safety was also associated with a 25% increase in the likelihood of being active in leisure time (95% CI 1.01–1.54). Street lighting was related to higher levels of commuting physical activity (prevalence ratio: 1.89; 95% CI 1.28–2.80). Conclusions. Safety investments are essential for promoting physical activity among older adults in Brazil. PMID:22291723

  20. Missouri Elementary Science Safety Manual.

    ERIC Educational Resources Information Center

    Lemons, Judith L.

    The purpose of this safety manual is to provide a resource to help manage and minimize potential risks in science classrooms where students spend up to 60% of instructional time engaged in hands-on activities. Information on general laboratory safety, science equipment safety, safety with plants, safety with animals, safety with chemicals, field…

  1. Improving general practice computer systems for patient safety: qualitative study of key stakeholders

    PubMed Central

    Avery, Anthony J; Savelyich, Boki S P; Sheikh, Aziz; Morris, Caroline J; Bowler, Isobel; Teasdale, Sheila

    2007-01-01

    Objective The authors sought to identify ways in which the use of general practice computer systems could be improved to enhance safety in primary care. Design Qualitative study using semistructured interviews. Participants Thirty one participants, representing a broad range of relevant disciplines and interest groups. Participants included clinicians, computer system and drug database suppliers, academics with interests in health informatics and members of governmental, professional and patient representative bodies. Setting UK. Results Participants identified deficiencies in current systems that pose serious threats to patient safety. To bring about improvements, providers need to supply clinicians with safe, accurate and accessible information for decision support; be aware of the importance of human ergonomics in the design of hazard alerts; consider the value of audit trails and develop mechanisms to allow for the accurate transfer of information between clinical computer systems. These improvements in computer systems will be most likely to occur if mandated through regulations. Individual practices are in need of improved education and training which focuses, in particular, on providing support with recording data accurately and using call, recall and reminders effectively. Conclusion There are significant opportunities for improving the safety of general practice computer systems. Priorities include improving the knowledge base for clinical decision support, paying greater attention to human ergonomics in system design, improved staff training and the introduction of new regulations mandating system suppliers to satisfy essential safety requirements. PMID:17301200

  2. Optical pumping of generalized laser active materials.

    PubMed

    Fry, F H

    1967-11-01

    Results are presented of a computer-based study on the rate of excitation in the active cores of two types of optically pumped lasers as a function of a number of parameters of the active core. The absorption bands of the active materials are generated by Lorentzian and Gaussian functions. The excitation rate of the active core is proportional to the width of the absorption band at all depths of penetration. The plots of excitation rate as a function of frequency show curves similar to line reversal spectra and emphasize the importance of excitation some distance from the center of the absorption band in the slab model. In the cylindrical model, this wing pumping is even more important due to focusing. The effect of refractive index on the excitation rate is also described. PMID:20062337

  3. 20 CFR 220.142 - General information about work activity.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... RETIREMENT ACT DETERMINING DISABILITY Substantial Gainful Activity § 220.142 General information about work activity. (a) The nature of the claimant's work. If the claimant's duties require use of the claimant's... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false General information about work activity....

  4. 77 FR 22602 - Information Collection Activities: Well Control and Production Safety Training, Submitted for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-16

    ... paperwork requirements in the regulations under Subpart O, ``Well Control and Production Safety Training... Bureau of Safety and Environmental Enforcement (BSEE) Information Collection Activities: Well Control and Production Safety Training, Submitted for Office of Management and Budget (OMB) Review; Comment...

  5. 75 FR 35286 - Agency Information Collection Activities; Proposed Collection; Comment Request; Safety Standard...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ... Information Collection Activities; Proposed Collection; Comment Request; Safety Standard for Infant Walkers... estimates for the marking and instructional literature requirements in the Safety Standard for Infant... of information technology. Title: Safety Standard for Infant Walkers--16 CFR part 1216....

  6. Solar Energy Project, Activities: General Solar Topics.

    ERIC Educational Resources Information Center

    Tullock, Bruce, Ed.; And Others

    This guide contains lesson plans and outlines of activities which introduce students to concepts and issues relating to solar energy. Lessons frequently presented in the context of solar energy as it relates to contemporary energy problems. Each unit presents an introduction; objectives; necessary skills and knowledge; materials; method;…

  7. Software safety analysis activities during software development phases of the Microwave Limb Sounder (MLS)

    NASA Technical Reports Server (NTRS)

    Shaw, Hui-Yin; Sherif, Joseph S.

    2004-01-01

    This paper describes the MLS software safety analysis activities and documents the SSA results. The scope of this software safety effort is consistent with the MLS system safety definition and is concentrated on the software faults and hazards that may have impact on the personnel safety and the environment safety.

  8. General aviation activity survey. Annual summary report for 1992

    SciTech Connect

    Not Available

    1992-01-01

    This report presents the results of the annual General Aviation Activity Survey. The survey is conducted by the FAA to obtain information on the flight activity of the United States registered general aviation aircraft fleet. The report contains breakdowns of active aircraft, annual flight hours, average flight hours and other statistics by manufacturer/model group, aircraft type, state and region of based aircraft, and primary use. Also included are fuel consumption, lifetime airframe hours, engine hours, miles flown estimates, estimates of the number of landings, IFR hours flown, and grade of fuel consumed by the general aviation fleet. Aircraft, Aircraft activity, Aircraft use, Fuel consumption, General aviation, Hours flown, Miles flown.

  9. Evaluation of features to support safety and quality in general practice clinical software

    PubMed Central

    2011-01-01

    Background Electronic prescribing is now the norm in many countries. We wished to find out if clinical software systems used by general practitioners in Australia include features (functional capabilities and other characteristics) that facilitate improved patient safety and care, with a focus on quality use of medicines. Methods Seven clinical software systems used in general practice were evaluated. Fifty software features that were previously rated as likely to have a high impact on safety and/or quality of care in general practice were tested and are reported here. Results The range of results for the implementation of 50 features across the 7 clinical software systems was as follows: 17-31 features (34-62%) were fully implemented, 9-13 (18-26%) partially implemented, and 9-20 (18-40%) not implemented. Key findings included: Access to evidence based drug and therapeutic information was limited. Decision support for prescribing was available but varied markedly between systems. During prescribing there was potential for medicine mis-selection in some systems, and linking a medicine with its indication was optional. The definition of 'current medicines' versus 'past medicines' was not always clear. There were limited resources for patients, and some medicines lists for patients were suboptimal. Results were provided to the software vendors, who were keen to improve their systems. Conclusions The clinical systems tested lack some of the features expected to support patient safety and quality of care. Standards and certification for clinical software would ensure that safety features are present and that there is a minimum level of clinical functionality that clinicians could expect to find in any system.

  10. 29 CFR 500.103 - Activities not subject to vehicle safety standards.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Activities not subject to vehicle safety standards. 500.103... LABOR REGULATIONS MIGRANT AND SEASONAL AGRICULTURAL WORKER PROTECTION Motor Vehicle Safety and Insurance... Workers Motor Vehicle Safety § 500.103 Activities not subject to vehicle safety standards....

  11. 29 CFR 500.103 - Activities not subject to vehicle safety standards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Activities not subject to vehicle safety standards. 500.103... LABOR REGULATIONS MIGRANT AND SEASONAL AGRICULTURAL WORKER PROTECTION Motor Vehicle Safety and Insurance... Workers Motor Vehicle Safety § 500.103 Activities not subject to vehicle safety standards....

  12. 20 CFR 416.973 - General information about work activity.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false General information about work activity. 416.973 Section 416.973 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME... § 416.973 General information about work activity. (a) The nature of your work. If your duties...

  13. 32 CFR 634.40 - General off installation traffic activities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false General off installation traffic activities. 634... (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION Traffic Supervision § 634.40 General off installation traffic activities. In areas not under military control,...

  14. 32 CFR 634.40 - General off installation traffic activities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false General off installation traffic activities. 634... (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION Traffic Supervision § 634.40 General off installation traffic activities. In areas not under military control,...

  15. 32 CFR 634.40 - General off installation traffic activities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true General off installation traffic activities. 634... (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION Traffic Supervision § 634.40 General off installation traffic activities. In areas not under military control,...

  16. 32 CFR 634.40 - General off installation traffic activities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true General off installation traffic activities. 634... (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION Traffic Supervision § 634.40 General off installation traffic activities. In areas not under military control,...

  17. 32 CFR 634.40 - General off installation traffic activities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true General off installation traffic activities. 634... (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION Traffic Supervision § 634.40 General off installation traffic activities. In areas not under military control,...

  18. 20 CFR 404.1573 - General information about work activity.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false General information about work activity. 404.1573 Section 404.1573 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND... General information about work activity. (a) The nature of your work. If your duties require use of...

  19. 20 CFR 404.1573 - General information about work activity.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false General information about work activity. 404.1573 Section 404.1573 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND... General information about work activity. (a) The nature of your work. If your duties require use of...

  20. 20 CFR 404.1573 - General information about work activity.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false General information about work activity. 404.1573 Section 404.1573 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND... General information about work activity. (a) The nature of your work. If your duties require use of...

  1. 20 CFR 416.973 - General information about work activity.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false General information about work activity. 416.973 Section 416.973 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME... § 416.973 General information about work activity. (a) The nature of your work. If your duties...

  2. 20 CFR 404.1573 - General information about work activity.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false General information about work activity. 404.1573 Section 404.1573 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND... General information about work activity. (a) The nature of your work. If your duties require use of...

  3. Instructional games and activities for criticality safety training

    SciTech Connect

    Bullard, B.; McBride, J. )

    1993-01-01

    During the past several years, the Training and Management Systems Division (TMSD) staff of Oak Ridge Institute for Science and Education (ORISE) has designed and developed nuclear criticality safety (NCS) training programs that focus on high trainee involvement through the use of instructional games and activities. This paper discusses the instructional game, initial considerations for developing games, advantages and limitations of games, and how games may be used in developing and implementing NCS training. It also provides examples of the various instructional games and activities used in separate courses designed for Martin Marietta Energy Systems (MMES's) supervisors and U.S. Nuclear Regulatory Commission (NRC) fuel facility inspectors.

  4. Receptionist input to quality and safety in repeat prescribing in UK general practice: ethnographic case study

    PubMed Central

    Greenhalgh, Trisha; Russell, Jill; Myall, Michelle

    2011-01-01

    Objective To describe, explore, and compare organisational routines for repeat prescribing in general practice to identify contributors and barriers to safety and quality. Design Ethnographic case study. Setting Four urban UK general practices with diverse organisational characteristics using electronic patient records that supported semi-automation of repeat prescribing. Participants 395 hours of ethnographic observation of staff (25 doctors, 16 nurses, 4 healthcare assistants, 6 managers, and 56 reception or administrative staff), and 28 documents and other artefacts relating to repeat prescribing locally and nationally. Main outcome measures Potential threats to patient safety and characteristics of good practice. Methods Observation of how doctors, receptionists, and other administrative staff contributed to, and collaborated on, the repeat prescribing routine. Analysis included mapping prescribing routines, building a rich description of organisational practices, and drawing these together through narrative synthesis. This was informed by a sociological model of how organisational routines shape and are shaped by information and communications technologies. Results Repeat prescribing was a complex, technology-supported social practice requiring collaboration between clinical and administrative staff, with important implications for patient safety. More than half of requests for repeat prescriptions were classed as “exceptions” by receptionists (most commonly because the drug, dose, or timing differed from what was on the electronic repeat list). They managed these exceptions by making situated judgments that enabled them (sometimes but not always) to bridge the gap between the idealised assumptions about tasks, roles, and interactions that were built into the electronic patient record and formal protocols, and the actual repeat prescribing routine as it played out in practice. This work was creative and demanded both explicit and tacit knowledge

  5. General-Purpose Heat Source safety verification test series: SVT-1 through SVT-6

    NASA Astrophysics Data System (ADS)

    Pavone, D.; George, T. G.; Frantz, C. E.

    1985-06-01

    The General-Purpose Heat Source (GPHS) is a modular heat source that will supply energy for Radioisotope Thermoelectric Generators (RTGs) in space missions. The Safety Verification Tests (SVTs) are performed to assess the plutonium containment capability of heat source modules subjected to certain accident environments. This interim report described the GPHS module configuration, the test environment, and the response of the module components following simulated reentry and solid Earth impact. The specific test environment of these initial six tests results from failure of the booster rocket to place the spacecraft in a proper trajectory and subsequent reentry of the GPHS modules from Earth orbit.

  6. General-purpose heat source project and space nuclear safety fuels program. Progress report, February 1980

    SciTech Connect

    Maraman, W.J.

    1980-05-01

    This formal monthly report covers the studies related to the use of /sup 238/PuO/sub 2/ in radioisotopic power systems carried out for the Advanced Nuclear Systems and Projects Division of the Los Alamos Scientific Laboratory. The two programs involved are: General-Purpose Heat Source Development and Space Nuclear Safety and Fuels. Most of the studies discussed here are of a continuing nature. Results and conclusions described may change as the work continues. Published reference to the results cited in this report should not be made without the explicit permission of the person in charge of the work.

  7. Nuclear safety

    NASA Technical Reports Server (NTRS)

    Buden, D.

    1991-01-01

    Topics dealing with nuclear safety are addressed which include the following: general safety requirements; safety design requirements; terrestrial safety; SP-100 Flight System key safety requirements; potential mission accidents and hazards; key safety features; ground operations; launch operations; flight operations; disposal; safety concerns; licensing; the nuclear engine for rocket vehicle application (NERVA) design philosophy; the NERVA flight safety program; and the NERVA safety plan.

  8. Perceiving the General: The Multisemiotic Dimension of Students' Algebraic Activity

    ERIC Educational Resources Information Center

    Radford, Luis; Bardino, Caroline; Sabena, Cristina

    2007-01-01

    In this article, we deal with students' algebraic generalizations set in the context of elementary geometric-numeric patterns. Drawing from Vygotsky's psychology, Leont'ev's Activity Theory, and Husserl's phenomenology, we focus on the various semiotic resources mobilized by students in their passage from the particular to the general. Two small…

  9. 29 CFR 780.205 - Nursery activities generally.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Nursery activities generally. 780.205 Section 780.205 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS EXEMPTIONS APPLICABLE TO AGRICULTURE, PROCESSING OF AGRICULTURAL...

  10. The Activity Chain Safety and Liveness Specification of Composite Web Services

    NASA Astrophysics Data System (ADS)

    Chen, Bo; Huang, Xiaomei

    Web service composition is most impressing method for development and deployment of e-business. Description and modeling the behavior requirements of composite Web services for users and verifying composite Web service compliance to specific requirements is an important key in design of services. But most work does not address the issue of how to model the requirements that the BPEL4WS processes are supposed to satisfy. The specifications in verification works are general temporal relation based on activity or scenario in essence. Distinguish with these work, we propose a novel concept of behavior specification based on activity chain in which granularity is between activity and scenario. Chain existence mode, chain absence mode are designed to express such behavioral requirements based on activity chain that is similar with safety or liveness specification based on activity respectively. Encode them on Labeled Transition System LTS and then give them exact operation semantics. Finally, an example is illustrated.

  11. Appraisal of activating thoughts in generalized anxiety disorder.

    PubMed

    Upatel, Tanja; Gerlach, Alexander L

    2008-09-01

    Worrying may be an avoidance behaviour preventing the discomfort of imagining future threats. To study the link between phasic physiological activation and thought contents, we recruited 32 generalized anxiety disorder (GAD) patients and 31 controls and asked them to report whatever was in their mind just prior to whenever they were prompted. Half of 20 prompts were triggered by non-specific skin conductance fluctuations (activating thoughts). Controls judged activating thoughts as being less pleasant. GAD participants judged activating thoughts as more anxiety provoking, less relaxing and less controllable. Not the level of activation but the appraisal of activating thoughts in a catastrophic fashion differentiates GAD patients from controls. PMID:17900526

  12. Causation mechanisms in car-to-vulnerable road user crashes: implications for active safety systems.

    PubMed

    Habibovic, Azra; Davidsson, Johan

    2012-11-01

    Vulnerable road users (VRUs), such as pedestrians and bicyclists, are often involved in crashes with passenger cars. One way to prevent these crashes is to deploy active safety systems that support the car drivers and/or VRUs. However, to develop such systems, a thorough understanding of crash causation mechanisms is required. The aim of this study is to identify crash causation mechanisms from the perspective of the VRUs, and to explore the implications of these mechanisms for the development of active safety systems. Data originate from the European project SafetyNet, where 995 crashes were in-depth investigated using the SafetyNet Accident Causation System (SNACS). To limit the scope, this study analyzed only intersection crashes involving VRUs. A total of 56 VRU crashes were aggregated. Results suggest that, while 30% of the VRUs did not see the conflict car due to visual obstructions in the traffic environment, 70% of the VRUs saw the car before the collision, but still misunderstood the traffic situation and/or made an inadequate plan of action. An important implication that follows from this is that, while detection of cars is clearly an issue that needs to be addressed, it is even more important to help the VRUs to correctly understand traffic situation (e.g., does the driver intend to slow down, and if s/he does, is it to let the VRU cross or for some other reason?). The former issue suggests a role for various cooperative active safety systems, as the obstacles are generally impenetrable with regular sensors. The latter issue is less straightforward. While various systems can be proposed, such as providing gap size estimation and reducing the car speed variability, the functional merits of each such a system need to be further investigated. PMID:23036427

  13. 10 CFR 810.7 - Generally authorized activities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Energy DEPARTMENT OF ENERGY ASSISTANCE TO FOREIGN ATOMIC ENERGY ACTIVITIES § 810.7 Generally authorized activities. In accordance with section 57b(2) of the Atomic Energy Act, the Secretary of Energy has... United States of America and the International Atomic Energy Agency for the Application of Safeguards...

  14. 10 CFR 810.7 - Generally authorized activities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Energy DEPARTMENT OF ENERGY ASSISTANCE TO FOREIGN ATOMIC ENERGY ACTIVITIES § 810.7 Generally authorized activities. In accordance with section 57b(2) of the Atomic Energy Act, the Secretary of Energy has... United States of America and the International Atomic Energy Agency for the Application of Safeguards...

  15. 20 CFR 404.1573 - General information about work activity.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false General information about work activity. 404.1573 Section 404.1573 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Determining Disability and Blindness Substantial Gainful Activity §...

  16. Environmental assessment of general-purpose heat source safety verification testing

    SciTech Connect

    1995-02-01

    This Environmental Assessment (EA) was prepared to identify and evaluate potential environmental, safety, and health impacts associated with the Proposed Action to test General-Purpose Heat Source (GPHS) Radioisotope Thermoelectric Generator (RTG) assemblies at the Sandia National Laboratories (SNL) 10,000-Foot Sled Track Facility, Albuquerque, New Mexico. RTGs are used to provide a reliable source of electrical power on board some spacecraft when solar power is inadequate during long duration space missions. These units are designed to convert heat from the natural decay of radioisotope fuel into electrical power. Impact test data are required to support DOE`s mission to provide radioisotope power systems to NASA and other user agencies. The proposed tests will expand the available safety database regarding RTG performance under postulated accident conditions. Direct observations and measurements of GPHS/RTG performance upon impact with hard, unyielding surfaces are required to verify model predictions and to ensure the continual evolution of the RTG designs that perform safely under varied accident environments. The Proposed Action is to conduct impact testing of RTG sections containing GPHS modules with simulated fuel. End-On and Side-On impact test series are planned.

  17. General Framework for Animal Food Safety Traceability Using GS1 and RFID

    NASA Astrophysics Data System (ADS)

    Cao, Weizhu; Zheng, Limin; Zhu, Hong; Wu, Ping

    GS1 is global traceability standard, which is composed by the encoding system (EAN/UCC, EPC), the data carriers identified automatically (bar codes, RFID), electronic data interchange standards (EDI, XML). RFID is a non-contact, multi-objective automatic identification technique. Tracing of source food, standardization of RFID tags, sharing of dynamic data are problems to solve urgently for recent traceability systems. The paper designed general framework for animal food safety traceability using GS1 and RFID. This framework uses RFID tags encoding with EPCglobal tag data standards. Each information server has access tier, business tier and resource tier. These servers are heterogeneous and distributed, providing user access interfaces by SOAP or HTTP protocols. For sharing dynamic data, discovery service and object name service are used to locate dynamic distributed information servers.

  18. General-Purpose Heat Source Safety Verification Test series: SVT-7 through SVT-10

    SciTech Connect

    George, T.G.; Pavone, D.

    1985-09-01

    The General-Purpose Heat Source (GPHS) is a modular component of the radioisotope thermoelectric generator that will supply power for the Galileo and Ulysses (formerly ISPM) space missions. The GPHS provides power by transmitting the heat of /sup 238/PuO/sub 2/ ..cap alpha..-decay to an array of thermoelectric elements. Because the possibility of an orbital abort always exists, the heat source was designed and constructed to minimize plutonia release in any accident environment. The Safety Verification Test (SVT) series was formulated to evaluate the effectiveness of GPHS plutonia containment after atmospheric reentry and Earth impact. The first report (covering SVT-1 through SVT-6) described the results of flat and side-on module impacts. This report describes module impacts at angles of 15/sup 0/ and 30/sup 0/.

  19. Safety review of the design, operation, and radiation sections of the General Electric Morris Operation Consolidated Safety Analysis Report

    SciTech Connect

    McBride, J.P.

    1981-01-30

    A safety review was made of Sections 4 through 9 of the Consolidated Safety Analysis Report (CSAR) for the GE Morris Operation spent-fuel storage facility. The sections reviewed include Design Criteria and Compliance, Facility Design and Description, Radiation Protection, Accident Analysis, and Conduct of Operations. The safety review was performed in accordance with the Code of Federal Regulations, Title 10, Part 72, ''Licensing Requirements for the Storage of Spent Fuel in an Independent Spent Fuel Storage Installation'' and contains independent estimations of source terms and dose-commitments from postulated accidents in the storage facility and a structural analysis of the Morris Operation cranes as an appendix. The review confirms that the features of the facility as described in Sections 4 through 9 of the CSAR fulfilled the safety requirements of 10 CFR 72, and it is concluded that spent-fuel handling and storage at the Morris Operation do not present significant risks to public health and safety. 15 refs., 3 tabs.

  20. Field studies of safety security rescue technologies through training and response activities

    NASA Astrophysics Data System (ADS)

    Murphy, Robin R.; Stover, Sam

    2006-05-01

    This paper describes the field-oriented philosophy of the Institute for Safety Security Rescue Technology (iSSRT) and summarizes the activities and lessons learned during calendar year 2005 of its two centers: the Center for Robot-Assisted Search and Rescue and the NSF Safety Security Rescue industry/university cooperative research center. In 2005, iSSRT participated in four responses (La Conchita, CA, Mudslides, Hurricane Dennis, Hurricane Katrina, Hurricane Wilma) and conducted three field experiments (NJTF-1, Camp Hurricane, Richmond, MO). The lessons learned covered mobility, operator control units, wireless communications, and general reliability. The work has collectively identified six emerging issues for future work. Based on these studies, a 10-hour, 1 continuing education unit credit course on rescue robotics has been created and is available. Rescue robots and sensors are available for loan upon request.

  1. IAEA Activities in the Area of Safety Analysis and Accident Management

    SciTech Connect

    Lee, S.; El-Shanawany, M.

    2006-07-01

    Safety analysis is a means of demonstrating how critical safety functions, the integrity of barriers against the release of radioactive materials, and various other safety requirements are fulfilled for a broad range of operating conditions and initiating events. Accordingly, performing safety analysis for a nuclear power plant is one of the most important safety principles. Thermal-hydraulic computer codes are extensively used worldwide for safety analysis by utilities, regulatory authorities, power plant designers and vendors, nuclear fuel companies, research organizations, and technical support organizations. Safety analysis methodology and computer codes have seen a significant development over the last two decades. This fact is also reflected in the work of the International Atomic Energy Agency (IAEA) that aims at increasing the quality and international harmonization of the approaches used in safety analysis. The paper provides an overview of activities and of examples of results obtained recently or planned in the near future in the IAEA's Division of Nuclear Installation Safety in the field of safety analysis for both design basis accidents and beyond design basis accidents as well as accident management. In this paper, specific technical guidance on the safety assessments in the IAEA Safety Standards such as safety analysis methodologies, probabilistic safety assessment, and development of accident management programmes are described. Future trends and related activities in safety analysis and accident management are also introduced. (authors)

  2. Safety of iobitridol in the general population and at-risk patients.

    PubMed

    Vogl, Thomas J; Honold, Elmar; Wolf, Michael; Mohajeri, H; Hammerstingl, R

    2006-06-01

    The purpose of this study was to review the rate of adverse events after contrast medium administration in the general population and at-risk patients (renal impairment, heart failure (NYHA III or IV), hypotension or hypertension, coronary artery disease, previous reaction to contrast media, asthma and/or allergies, dehydration, diabetes mellitus, poor general condition) under daily practice conditions in a post-marketing surveillance study. Two hundred and ten radiologists conducted various X-ray examinations in 52,057 patients. To document the safety of iobitridol in routine use, all patients undergoing X-ray examinations were included. Exclusion criteria were contraindications listed in the locally approved summary of product characteristics. The adverse event rate was 0.96% (at-risk patients 1.39%); the rate of serious adverse events 0.044% in all patients (at-risk patients 0.057%). Adverse events occurred more often in women than in men (P < 0.001). In patients who had previously reacted to a contrast medium, adverse events were reported in 3.43% with mild to moderate symptoms. In 47.76% of these patients, a premedication was administered. There was no difference in the frequency of adverse events and serious adverse events whether premedicated or not (P = 0.311 and P = 0.295, respectively). Iobitridol was well-tolerated in 99.04% of cases (at-risk patients 98.61%). PMID:16429272

  3. 76 FR 45904 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ... of Pipeline Safety, Training. OMB Control Number: 2137-0600. Current Expiration Date: 2/29/2012... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477) or visit... Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection...

  4. 76 FR 81013 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ... Statement in the Federal Register published on April 11, 2000 (65 FR 19477) or visit http://www.regulations... Pipeline Safety Program Certification and Hazardous Liquid Pipeline Safety Program Certification.'' PHMSA... Liquid Pipeline Safety Program Certification. OMB Control Number: 2137-0584. Current Expiration Date:...

  5. 75 FR 77694 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-13

    ... Register on November 26, 2010 (75 FR 72878), titled: ``Pipeline Safety: Updates to Pipeline and Liquefied... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477) or visit... Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection...

  6. 21 CFR 170.20 - General principles for evaluating the safety of food additives.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... proposed experiments to determine its safety, the Commissioner will advise a person who wishes to establish the safety of a food additive whether he believes the experiments planned will yield data adequate...

  7. 21 CFR 570.20 - General principles for evaluating the safety of food additives.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... and the proposed experiments to determine its safety, the Commissioner will advise a person who wishes to establish the safety of a food additive whether he believes the experiments planned will...

  8. 21 CFR 170.20 - General principles for evaluating the safety of food additives.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... proposed experiments to determine its safety, the Commissioner will advise a person who wishes to establish the safety of a food additive whether he believes the experiments planned will yield data adequate...

  9. 21 CFR 170.20 - General principles for evaluating the safety of food additives.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... proposed experiments to determine its safety, the Commissioner will advise a person who wishes to establish the safety of a food additive whether he believes the experiments planned will yield data adequate...

  10. 21 CFR 570.20 - General principles for evaluating the safety of food additives.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... and the proposed experiments to determine its safety, the Commissioner will advise a person who wishes to establish the safety of a food additive whether he believes the experiments planned will...

  11. 21 CFR 570.20 - General principles for evaluating the safety of food additives.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... and the proposed experiments to determine its safety, the Commissioner will advise a person who wishes to establish the safety of a food additive whether he believes the experiments planned will...

  12. 21 CFR 570.20 - General principles for evaluating the safety of food additives.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... and the proposed experiments to determine its safety, the Commissioner will advise a person who wishes to establish the safety of a food additive whether he believes the experiments planned will...

  13. 21 CFR 170.20 - General principles for evaluating the safety of food additives.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... proposed experiments to determine its safety, the Commissioner will advise a person who wishes to establish the safety of a food additive whether he believes the experiments planned will yield data adequate...

  14. Patient safety in primary care: incident reporting and significant event reviews in British general practice.

    PubMed

    Rea, David; Griffiths, Sarah

    2016-07-01

    Over the past 20 years, healthcare has adapted to the 'quality revolution' by moving away from direct provision and hierarchical control mechanisms. In their place, new structures based on contractual relationships are being developed coupled with attempts to create an organisational culture that shares learning and that scrutinises existing practice so that it can be improved. The issue here is that contractual arrangements require surveillance, monitoring, regulation and governance systems that can be perceived as antipathetic to the examination of practice and subsequent learning. Historically, reporting levels from general practice have remained low; little information is shared and consequently lessons are not shared across the general practice community. Given large-scale under-engagement of general practitioners (GPs) in incident reporting systems, significant event analysis is advocated to encourage sharing of information about incidents to inform the patient safety agenda at a local and national level. Previous research has concentrated on the secondary care environment and little is known about the situation in primary care, where the majority of patient contacts with healthcare occur. To explore attitudes to incident reporting, the study adopted a qualitative approach to GPs working in a mixture of urban and rural practices reporting to a Welsh Local Health Board. The study found that GPs used significant event analysis methodology to report incidents within their practice, but acknowledged under-reporting. They were less enthusiastic about reporting externally. A number of barriers exist to reporting, including insufficient time to report, lack of feedback, fear of blame, and damage to reputations and patient confidence in a competitive environment. If incident reporting processes are perceived as supportive and formative, and where protected time is allocated to discuss incidents, then GPs are willing to participate. They also need to know how the

  15. 50 CFR 37.11 - General standards for exploratory activities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false General standards for exploratory activities. 37.11 Section 37.11 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE SYSTEM GEOLOGICAL AND GEOPHYSICAL EXPLORATION OF THE COASTAL PLAIN, ARCTIC NATIONAL...

  16. 50 CFR 37.11 - General standards for exploratory activities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false General standards for exploratory activities. 37.11 Section 37.11 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE SYSTEM GEOLOGICAL AND GEOPHYSICAL EXPLORATION OF THE COASTAL PLAIN, ARCTIC NATIONAL...

  17. Solar energy education. Renewable energy activities for general science

    SciTech Connect

    Not Available

    1985-01-01

    Renewable energy topics are integrated with the study of general science. The literature is provided in the form of a teaching manual and includes such topics as passive solar homes, siting a home for solar energy, and wind power for the home. Other energy topics are explored through library research activities. (BCS)

  18. Safety-Related Activities of the IAEA for Radioactive Waste, Decommissioning and Remediation - 13473

    SciTech Connect

    Hahn, Pil-Soo; Vesterlind, Magnus

    2013-07-01

    To fulfil its mandate and serve the needs of its Member States, the IAEA is engaged in a wide range of safety-related activities pertaining to radioactive waste management, decommissioning and remediation. One of the statutory obligations of the IAEA is to establish safety standards and to provide for the application of these standards. The present paper describes recent developments in regard to the IAEA's waste safety standards, and some of the ways the IAEA makes provision for their application. The safety standards and supporting safety demonstration projects seek to establish international consensus on methodologies and approaches for dealing with particular subject areas, for example, safety assessment for radioactive waste disposal. (authors)

  19. Activities of the US-Japan Safety Monitor Joint Working Group

    SciTech Connect

    Richard L. Savercool; Lee C. Cadwallader

    2004-09-01

    This paper documents the activities of the US-Japan exchange in the area of personnel safety at magnetic and laser fusion experiments. A near-miss event with a visiting scientist to the US in 1992 was the impetus for forming the Joint Working Group on Fusion Safety. This exchnge has been under way for over ten years and has provided many safety insights for both US and Japanese facility personnel at national institutes and at universities. The background and activities of the Joint Working Group are described, including the facilities that have been visited for safety walkthroughs, the participants from both countries, and the main safety issues examined during visits. Based on these visits, some operational safety ideas to enhance experiment safety are given. The near-term future plans of the Safety Monitor Joint Working group are also discussed.

  20. Safety.

    ERIC Educational Resources Information Center

    Education in Science, 1996

    1996-01-01

    Discusses safety issues in science, including: allergic reactions to peanuts used in experiments; explosions in lead/acid batteries; and inspection of pressure vessels, such as pressure cookers or model steam engines. (MKR)

  1. General-Purpose Heat Source Safety Verification Test program: Edge-on flyer plate tests

    SciTech Connect

    George, T.G.

    1987-03-01

    The radioisotope thermoelectric generator (RTG) that will supply power for the Galileo and Ulysses space missions contains 18 General-Purpose Heat Source (GPHS) modules. The GPHS modules provide power by transmitting the heat of STYPu -decay to an array of thermoelectric elements. Each module contains four STYPuO2-fueled clads and generates 250 W(t). Because the possibility of a launch vehicle explosion always exists, and because such an explosion could generate a field of high-energy fragments, the fueled clads within each GPHS module must survive fragment impact. The edge-on flyer plate tests were included in the Safety Verification Test series to provide information on the module/clad response to the impact of high-energy plate fragments. The test results indicate that the edge-on impact of a 3.2-mm-thick, aluminum-alloy (2219-T87) plate traveling at 915 m/s causes the complete release of fuel from capsules contained within a bare GPHS module, and that the threshold velocity sufficient to cause the breach of a bare, simulant-fueled clad impacted by a 3.5-mm-thick, aluminum-alloy (5052-T0) plate is approximately 140 m/s.

  2. General-Purpose Heat Source development: Safety Verification Test Program. Bullet/fragment test series

    SciTech Connect

    George, T.G.; Tate, R.E.; Axler, K.M.

    1985-05-01

    The radioisotope thermoelectric generator (RTG) that will provide power for space missions contains 18 General-Purpose Heat Source (GPHS) modules. Each module contains four /sup 238/PuO/sub 2/-fueled clads and generates 250 W/sub (t)/. Because a launch-pad or post-launch explosion is always possible, we need to determine the ability of GPHS fueled clads within a module to survive fragment impact. The bullet/fragment test series, part of the Safety Verification Test Plan, was designed to provide information on clad response to impact by a compact, high-energy, aluminum-alloy fragment and to establish a threshold value of fragment energy required to breach the iridium cladding. Test results show that a velocity of 555 m/s (1820 ft/s) with an 18-g bullet is at or near the threshold value of fragment velocity that will cause a clad breach. Results also show that an exothermic Ir/Al reaction occurs if aluminum and hot iridium are in contact, a contact that is possible and most damaging to the clad within a narrow velocity range. The observed reactions between the iridium and the aluminum were studied in the laboratory and are reported in the Appendix.

  3. General-Purpose Heat Source Development: Safety Verification Test Program. Flyer plate test series

    SciTech Connect

    Cull, T.A.; Pavone, D.

    1986-09-01

    The General-Purpose Heat Source (GPHS) is a modular component of a radioisotope thermoelectric generator (RTG) that will provide electric power for space missions. The initial RTG applications will be for the NASA Galileo and the ESA Ulysses missions. Each of the 18 GPHS modules in an RTG contains four /sup 238/PuO/sub 2/-fueled clads and generates 250 W/sub (t)/. A series of Safety Verification Tests (SVTs) has been conducted to assess the ability of the GPHS fueled clads to contain the plutonia in accident environments. Because a launch pad or postlaunch explosion of the Space Transportation System Vehicle (space shuttle) is one conceivable accident, the SVT plan included a series of tests to simulate the fragment environment that the RTG and GPHS modules would experience in such an event. These tests deal specifically with the flat-on collision of flyer-plate-type fragments with bare, simulant-fueled (depleted UO/sub 2/) clads. Results of these tests suggest that the fueled clad is only minimally breached by collision with 3.53-mm-thick flyer-plate-type fragments of space shuttle alloy at velocities up to 1170 m/s. However, collision of a 38.1-mm-thick plate with a bare GPHS clad, at a velocity of 270 m/s, results in a total release of fuel.

  4. Enhancing patient safety through the management of Clostridium difficile at Toronto East General Hospital.

    PubMed

    Tomiczek, Arladeen; Stumpo, C; Downey, James F

    2006-01-01

    In 2005 Toronto East General Hospital experienced a steady increase in the number of C. difficile cases diagnosed within the hospital. This was identified as a patient safety issue, and several areas of the hospital came together to address the problem. Pharmacy immediately started a medication review of past cases. Environmental services took the lead on the environmental cleaning, and a process was put into place with Infection Control so that housekeeping knew of every room that contained a patient with C. difficile and enhanced cleaning could be practised. Staff, including nursing, housekeeping and porters, were educated on C. difficile and the methods of transmission. A business case was developed for a disposable bedpan system, and this was approved by the senior team. A new washable product was tried out with success for the overhead patient light pulls and bathroom call bell systems. Infection rates were shared with staff through a variety of venues. As a result of the initiatives, the hospital has seen a decrease of 50% in the rates of C. difficile. A bonus was that our MRSA rates dropped as well. PMID:17087168

  5. Explosion overpressure test series: General-Purpose Heat Source development: Safety Verification Test program

    SciTech Connect

    Cull, T.A.; George, T.G.; Pavone, D.

    1986-09-01

    The General-Purpose Heat Source (GPHS) is a modular, radioisotope heat source that will be used in radioisotope thermoelectric generators (RTGs) to supply electric power for space missions. The first two uses will be the NASA Galileo and the ESA Ulysses missions. The RTG for these missions will contain 18 GPHS modules, each of which contains four /sup 238/PuO/sub 2/-fueled clads and generates 250 W/sub (t)/. A series of Safety Verification Tests (SVTs) was conducted to assess the ability of the GPHS modules to contain the plutonia in accident environments. Because a launch pad or postlaunch explosion of the Space Transportation System vehicle (space shuttle) is a conceivable accident, the SVT plan included a series of tests that simulated the overpressure exposure the RTG and GPHS modules could experience in such an event. Results of these tests, in which we used depleted UO/sub 2/ as a fuel simulant, suggest that exposure to overpressures as high as 15.2 MPa (2200 psi), without subsequent impact, does not result in a release of fuel.

  6. General-Purpose Heat Source Safety Verification Test Program: Edge-on flyer plate tests

    NASA Astrophysics Data System (ADS)

    George, T. G.

    1987-03-01

    The radioisotope thermoelectric generator (RTG) that will supply power for the Galileo and Ulysses space missions contains 18 General-Purpose Heat Source (GPHS) modules. The GPHS modules provide power by transmitting the heat of Pu-238 alpha-decay to an array of thermoelectric elements. Each module contains four Pu-238O2-fueled clads and generates 250 W(t). Because the possibility of a launch vehicle explosion always exists, and because such an explosion could generate a field of high-energy fragments, the fueled clads within each GPHS module must survive fragment impact. The edge-on flyer plate tests were included in the Safety Verification Test series to provide information on the module/clad response to the impact of high-energy plate fragments. The test results indicate that the edge-on impact of a 3.2-mm-thick, aluminum-alloy (2219-T87) plate traveling at 915 m/s causes the complete release of fuel from capsules contained within a bare GPHS module, and that the threshold velocity sufficient to cause the breach of a bare, simulant-fueled clad impacted by a 3.5-mm-thick, aluminum-alloy (5052-TO) plate is approximately 140 m/s.

  7. General-purpose heat source project and space nuclear safety and fuels program. Progress report

    SciTech Connect

    Maraman, W.J.

    1980-02-01

    Studies related to the use of /sup 238/PuO/sub 2/ in radioisotopic power systems carried out for the Advanced Nuclear Systems and Projects Division of LASL are presented. The three programs involved are: general-purpose heat source development; space nuclear safety; and fuels program. Three impact tests were conducted to evaluate the effects of a high temperature reentry pulse and the use of CBCF on impact performance. Additionally, two /sup 238/PuO/sub 2/ pellets were encapsulated in Ir-0.3% W for impact testing. Results of the clad development test and vent testing are noted. Results of the environmental tests are summarized. Progress on the Stirling isotope power systems test and the status of the improved MHW tests are indicated. The examination of the impact failure of the iridium shell of MHFT-65 at a fuel pass-through continued. A test plan was written for vibration testing of the assembled light-weight radioisotopic heater unit. Progress on fuel processing is reported.

  8. Physical activity mediates the relationship between perceived crime safety and obesity

    PubMed Central

    Brown, Barbara B.; Werner, Carol M.; Smith, Ken R.; Tribby, Calvin P.; Miller, Harvey J.

    2014-01-01

    Objective The current cross-sectional study tests whether low perceived crime safety is associated with body mass index (BMI) and obesity risk and whether less moderate-to-vigorous physical activity (MVPA) accounts for part of this relationship. Method Adults (n=864) from a relatively low-income and ethnically mixed neighborhood in Salt Lake City UT (2012) were assessed for perceived crime safety, objective physical activity, and BMI measures. Results This neighborhood had lower perceived safety than for other published studies utilizing this safety measure. In a mediation test, lower perceived crime safety was significantly associated with higher BMI and greater risk of obesity, net of control variables. Residents with lower perceived safety had less MVPA. Lower MVPA partially explained the relationship between less safety and both elevated BMI and higher obesity risk, suggesting that perceiving less crime safety limits MVPA which, in turn, increases weight. Conclusion In this neighborhood, with relatively low perceived safety from crime, residents’ low perceived safety related to more obesity and higher BMI; lower MVPA among residents explained part of this relationship. If residents are to become more active in their neighborhood it may be important to address perceived crime safety as part of broader efforts to enhance active living. PMID:24963894

  9. Convoy active safety technologies war fighter experiment II

    NASA Astrophysics Data System (ADS)

    Schoenherr, Edward W.

    2009-01-01

    The operational ability to project and sustain forces in distant, anti-access and area denial environments poses new challenges for combatant commanders. One of the new challenges is the ability to conduct sustainment operations at operationally feasible times and places on the battlefield. Combatant commanders require a sustainment system that is agile, versatile, and survivable throughout the range of military operations and across the spectrum of conflict. A key component of conducting responsive, operationally feasible sustainment operations is the ability to conduct sustainment convoys. Sustainment convoys are critical to providing combatant commanders the right support, at the right time and place, and in the right quantities, across the full range of military operations. The ability to conduct sustainment convoys in a variety of hostile environments require force protection measures that address the enemy threat and protect the Soldier. One cost effective, technically feasible method of increasing the force protection for sustainment convoys is the use of robotic follower technology and autonomous navigation. The Convoy Active Safety Technologies (CAST) system is a driver assist, convoy autopilot technology aimed to address these issues. The CAST Warfigher Experiment II, being held at The Nevada Automotive Test Center in the fall of 2008, will continue analysis of the utility of this vehicle following technology not only in measures of system integrity and performance vs. manual driving, but also the physiological effects on the operators themselves. This paper will detail this experiment's methodology and analysis. Results will be presented at the SPIE Electronic Imaging 2009 symposium.

  10. 77 FR 46155 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-02

    ... information collection was published in the Federal Register on May 9, 2012, (77 FR 27279) under Docket No... April 11, 2000, (65 FR 19477) or visit http://www.regulations.gov before submitting any such comments... Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection...

  11. 75 FR 30099 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-28

    ... 23, 2010, (75 FR 13807). The agency did not receive any comments. The information collection is... Rulemaking for the One Rule was published in the Federal Register on July 2, 2009, (74 FR 31675) and comments... TRANSPORTATION Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information...

  12. Evaluation of Antioxidant, Immunomodulatory Activities, and Safety of Ethanol Extract and Fractions of Gongronema latifolium Fruit

    PubMed Central

    Agwaramgbo, Amanze; Ilodigwe, Emmanuel Emeka; Ajaghaku, Daniel Lotanna; Onuorah, Maureen Ugochukwu; Mbagwu, Sonne Ikechukwu

    2014-01-01

    Gongronema latifolium fruit has wide application in ethnomedicine, especially in maintaining healthy living and general body healing. We therefore investigated the antioxidant, immunomodulatory activities, and safety of its ethanol extract and fractions. The in vitro antioxidant activities of the extract and fractions were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) test while in vivo activities were determined using carbon tetrachloride (CCL4) induced oxidative stress. Cell and humoral mediated immune responses were also evaluated together with toxicity studies. The extract, ethyl acetate, and methanol fractions showed inhibition of DPPH radical with IC50s 120, 90, and 60 μg/mL, respectively. Methanol fraction at 200 mg/kg produced significant (P < 0.05) inhibition of lipid peroxidation (MDA conc. 1.2 μmol/L) compared to control (2.8 μmol/L). Both ethyl acetate and methanol fractions at 200 mg/kg produced significant (P < 0.05) phagocytic index of 0.021 and 0.025, respectively, compared with control (0.01). Significant (P < 0.05) elevations of white blood cells, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase were noticed on the 91st day at higher doses. Generally, this study justified the traditional use of G. latifolium fruit for general body healing and maintenance of healthy living. Long term administration is safe on the haematological and biochemical systems especially at lower doses and its toxicity at higher doses is reversible. PMID:27433504

  13. Evaluation of Antioxidant, Immunomodulatory Activities, and Safety of Ethanol Extract and Fractions of Gongronema latifolium Fruit.

    PubMed

    Agwaramgbo, Amanze; Ilodigwe, Emmanuel Emeka; Ajaghaku, Daniel Lotanna; Onuorah, Maureen Ugochukwu; Mbagwu, Sonne Ikechukwu

    2014-01-01

    Gongronema latifolium fruit has wide application in ethnomedicine, especially in maintaining healthy living and general body healing. We therefore investigated the antioxidant, immunomodulatory activities, and safety of its ethanol extract and fractions. The in vitro antioxidant activities of the extract and fractions were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) test while in vivo activities were determined using carbon tetrachloride (CCL4) induced oxidative stress. Cell and humoral mediated immune responses were also evaluated together with toxicity studies. The extract, ethyl acetate, and methanol fractions showed inhibition of DPPH radical with IC50s 120, 90, and 60 μg/mL, respectively. Methanol fraction at 200 mg/kg produced significant (P < 0.05) inhibition of lipid peroxidation (MDA conc. 1.2 μmol/L) compared to control (2.8 μmol/L). Both ethyl acetate and methanol fractions at 200 mg/kg produced significant (P < 0.05) phagocytic index of 0.021 and 0.025, respectively, compared with control (0.01). Significant (P < 0.05) elevations of white blood cells, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase were noticed on the 91st day at higher doses. Generally, this study justified the traditional use of G. latifolium fruit for general body healing and maintenance of healthy living. Long term administration is safe on the haematological and biochemical systems especially at lower doses and its toxicity at higher doses is reversible. PMID:27433504

  14. Activities affecting surface water resources: A general overview

    SciTech Connect

    Not Available

    1990-01-01

    In November 1987, P.E.I. signed a federal/provincial work-sharing arrangement on water resource management focusing on groundwater pollution, surface water degradation and estuarine eutrophication. The surface water program was designed to identify current surface water uses and users within 12 major watersheds across the Island containing 26 individual rivers, as well as problems arising due to practices that degrade the quality of surface water and restricts its value to other user groups. This report presents a general overview of the program, covering the general characteristics of the Island; operations in agriculture, fish and wildlife, forestry, recreation, fisheries, and industry; alterations of natural features of waterways; wetlands; additional watershed activities such as hydrometric stations and subdivision development; and activities affecting surface water resources such as sedimentation sources, pollution point sources and instream obstructions.

  15. 10 CFR Appendix A to Subpart B of... - General Statement of Safety Basis Policy

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    .... Introduction This appendix describes DOE's expectations for the safety basis requirements of 10 CFR Part 830..., safety, and health into work planning and execution (48 CFR 970.5223-1, Integration of Environment... directives (48 CFR 970.5204-2, Laws, Regulations and DOE Directives), the contractor will have...

  16. 10 CFR Appendix A to Subpart B of... - General Statement of Safety Basis Policy

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... Introduction This appendix describes DOE's expectations for the safety basis requirements of 10 CFR Part 830..., safety, and health into work planning and execution (48 CFR 970.5223-1, Integration of Environment... directives (48 CFR 970.5204-2, Laws, Regulations and DOE Directives), the contractor will have...

  17. 41 CFR 50-204.2 - General safety and health standards.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Other Nonmetallic Minerals, Including Silica Sand. (3) U.S. Department of Transportation: 49 CFR parts 171-179 and 14 CFR part 103 Hazardous material regulation—Transportation of compressed gases. (4) U.S... Labor—Title 29 CFR— Part 1501—Safety and Health Regulations for Ship Repairing. Part 1502—Safety...

  18. 41 CFR 50-204.2 - General safety and health standards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Labor—Title 29 CFR— Part 1501—Safety and Health Regulations for Ship Repairing. Part 1502—Safety and... Other Nonmetallic Minerals, Including Silica Sand. (3) U.S. Department of Transportation: 49 CFR parts 171-179 and 14 CFR part 103 Hazardous material regulation—Transportation of compressed gases. (4)...

  19. General Safety Manual for Vocational-Technical Education and Industrial Arts Programs. Bulletin No. 1674.

    ERIC Educational Resources Information Center

    Dennis, Bill; Poston, David

    This manual is designed to offer suggestions for teaching safety in Louisiana industrial arts and vocational education programs. The suggestions and information presented are intended for use in an ongoing safety program, not a short unit presented at the beginning of the school year. Following an introduction in unit 1, the material has been…

  20. 10 CFR Appendix A to Subpart B of... - General Statement of Safety Basis Policy

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... basis requirements, DOE revised the language in 10 CFR 830.122(e)(1) to make clear that hazard controls.... Introduction This appendix describes DOE's expectations for the safety basis requirements of 10 CFR Part 830..., safety, and health into work planning and execution (48 CFR 970.5223-1, Integration of...

  1. Generalized event knowledge activation during online sentence comprehension

    PubMed Central

    Metusalem, Ross; Kutas, Marta; Urbach, Thomas P.; Hare, Mary; McRae, Ken; Elman, Jeffrey L.

    2012-01-01

    Recent research has demonstrated that knowledge of real-world eventsplays an important role inguiding online language comprehension. The present study addresses the scope of event knowledge activation during the course of comprehension, specifically investigating whether activation is limited to those knowledge elements that align with the local linguistic context.The present study addresses this issue by analyzing event-related brain potentials (ERPs) recorded as participants read brief scenariosdescribing typical real-world events. Experiment 1 demonstratesthat a contextually anomalous word elicits a reduced N400 if it is generally related to the described event, even when controlling for the degree of association of this word with individual words in the preceding context and with the expected continuation. Experiment 2 shows that this effect disappears when the discourse context is removed.These findings demonstrate that during the course of incremental comprehension, comprehenders activate general knowledge about the described event, even at points at which this knowledge would constitute an anomalous continuation of the linguistic stream. Generalized event knowledge activationcontributes to mental representations of described events, is immediately available to influence language processing, and likely drives linguistic expectancy generation. PMID:22711976

  2. Auto Mechanics I. Learning Activity Packets (LAPs). Section A--Orientation and Safety.

    ERIC Educational Resources Information Center

    Oklahoma State Board of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains seven learning activity packets (LAPs) that outline the study activities for the orientation and safety instructional area for an Auto Mechanics I course. The seven LAPs cover the following topics: orientation, safety, hand tools, arc welding, oxyacetylene cutting, oxyacetylene fusion welding, and oxyacetylene braze welding.…

  3. Operation Safety Activities for JEM System and Payload Operation

    NASA Astrophysics Data System (ADS)

    Takada, Satomi; Iwata, Yoshihiro; Kato, Mitsuyasu

    2010-09-01

    The Japanese Experiment Module(JEM), "KIBO", which is a part of the International Space Station(ISS) is the first Japanese manned space experimental facility. JEM system and payloads have made the birth of an era of operation. The JAXA Human Space S&MA(JAXA S&MA) assures safety of JEM module and JAXA payloads not only during assembly phase but also operation phase. During the safety critical operation for JEM system and payloads, JAXA S&MA is on ESR S&MA console to monitor the operation related to safety. Safety check list is made for each safety critical task to identify the useful information such as hazard control, operational constraints and flight rules, and so on. It is a support tool for JAXA S&MA to monitor the operation overall. JAXA S&MA has the responsibility of assessing the safety related updates or changes of operational documents. JAXA S&MA will continue to support the JEM operation as long as the operation is continued.

  4. Seismic analysis of the large 70-meter antenna. Part 2: General dynamic response and a seismic safety check

    NASA Technical Reports Server (NTRS)

    Kiedron, K.; Chian, C. T.

    1985-01-01

    An extensive dynamic analysis for the new JPL 70-meter antenna structure is presented. Analytical procedures are based on the normal mode decomposition which include dumping and special forcing functions. The dynamic response can be obtained for any arbitrarily selected point on the structure. A new computer program for computing the time-dependent, resultant structural displacement, summing the effects of all participating modes, was developed also. Program compatibility with natural frequency analysis output was verified. The program was applied to the JPL 70-meter antenna structure and the dynamic response for several specially selected points was computed. Seismic analysis of structures, a special application of the general dynamic analysis, is based also on the normal modal decomposition. Strength specification of the antenna, with respect to the earthquake excitation, is done by using the common response spectra. The results indicated basically a safe design under an assumed 5% or more damping coefficient. However, for the antenna located at Goldstone, with more active seismic environment, this study strongly recommends and experimental program that determines the true damping coefficient for a more reliable safety check.

  5. Perceived crime and traffic safety is related to physical activity among adults in Nigeria

    PubMed Central

    2012-01-01

    Background Neighborhood safety is inconsistently related to physical activity, but is seldom studied in developing countries. This study examined associations between perceived neighborhood safety and physical activity among Nigerian adults. Methods In a cross-sectional study, accelerometer-based physical activity (MVPA), reported walking, perceived crime and traffic safety were measured in 219 Nigerian adults. Logistic regression analysis was conducted, and the odds ratio for meeting health guidelines for MVPA and walking was calculated in relation to four safety variables, after adjustment for potential confounders. Results Sufficient MVPA was related to more perception of safety from traffic to walk (OR=2.28, CI=1.13- 6.25) and more safety from crime at night (OR=1.68, CI=1.07-3.64), but with less perception of safety from crime during the day to walk (OR=0.34, CI=0.06- 0.91). More crime safety during the day and night were associated with more walking. Conclusions Perceived safety from crime and traffic were associated with physical activity among Nigerian adults. These findings provide preliminary evidence on the need to provide safe traffic and crime environments that will make it easier and more likely for African adults to be physically active. PMID:22520066

  6. Associations of adult physical activity with perceived safety and police-recorded crime: the Multi-ethnic Study of Atherosclerosis

    PubMed Central

    2012-01-01

    Background Due to the inconsistent findings of prior studies, we explored the association of perceived safety and police-recorded crime measures with physical activity. Methods The study included 818 Chicago participants of the Multiethnic Study of Atherosclerosis 45 to 84 years of age. Questionnaire-assessed physical activity included a) transport walking; b) leisure walking; and c) non-walking leisure activities. Perceived safety was assessed through an interviewer-administered questionnaire. Police-recorded crime was assessed through 2-year counts of selected crimes (total and outdoor incivilities, criminal offenses, homicides) per 1000 population. Associations were examined using generalized estimating equation logistic regression models. Results Perceiving a safer neighborhood was positively associated with transport walking and perceiving lower violence was associated with leisure walking. Those in the lowest tertile of total or outdoor incivilities were more likely to report transport walking. Models with both perceived safety and police-recorded measures of crime as independent variables had superior fit for both transport walking and leisure walking outcomes. Neither perceived safety nor police-recorded measures of crime were associated with non-walking leisure activity. Conclusions Perceived and police-recorded measures had independent associations with walking and both should be considered in assessing the impact of neighborhood crime on physical activity. PMID:23245527

  7. Restructuring within an academic health center to support quality and safety: the development of the Center for Quality and Safety at the Massachusetts General Hospital.

    PubMed

    Bohmer, Richard M J; Bloom, Jonathan D; Mort, Elizabeth A; Demehin, Akinluwa A; Meyer, Gregg S

    2009-12-01

    Recent focus on the need to improve the quality and safety of health care has created new challenges for academic health centers (AHCs). Whereas previously quality was largely assumed, today it is increasingly quantifiable and requires organized systems for improvement. Traditional structures and cultures within AHCs, although well suited to the tripartite missions of teaching, research, and clinical care, are not easily adaptable to the tasks of measuring, reporting, and improving quality. Here, the authors use a case study of Massachusetts General Hospital's efforts to restructure quality and safety to illustrate the value of beginning with a focus on organizational culture, using a systematic process of engaging clinical leadership, developing an organizational framework dependent on proven business principles, leveraging focus events, and maintaining executive dedication to execution of the initiative. The case provides a generalizable example for AHCs of how applying explicit management design can foster robust organizational change with relatively modest incremental financial resources. PMID:19940570

  8. Mine safety: Occupational health -- general studies. (Latest citations from the NTIS Bibliographic database). Published Search

    SciTech Connect

    Not Available

    1994-04-01

    The bibliography contains citations concerning occupational hazards in the metals and fossil fuel mining environment. Topics include the detection, control and effects of respirable dust, safety aspects of various mining methods, gas detection, and field surveys of specific operations. Some attention is given to legislative aspects of mine safety and benefits to the disabled. (Contains 250 citations and includes a subject term index and title list.)

  9. Mine safety: Occupational health -- general studies. (Latest citations from the NTIS bibliographic database). Published Search

    SciTech Connect

    1996-07-01

    The bibliography contains citations concerning occupational hazards in the metals and fossil fuel mining environment. Topics include the detection, control and effects of respirable dust, safety aspects of various mining methods, gas detection, and field surveys of specific operations. Some attention is given to legislative aspects of mine safety and benefits to the disabled.(Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  10. Evaluating oral health promotion activity within a general dental practice.

    PubMed

    Richards, W

    2013-07-01

    The prevention of the common dental diseases is fundamental to modern day general dental practice. Oral health promotion (OHP) is therefore key to facilitating health outcomes within organisations. The literature surrounding OHP stresses the importance of evaluation in order to assess the effectiveness of OHP activities. This paper describes the evaluation of OHP within a general dental practice setting. Early attendance, the use of adult toothpastes during childhood and consequential fluorosis are investigated. A small service evaluation study of 100 consecutive patients was undertaken. The results support the ongoing promotion of early attendance and the use of toothpastes with adequate fluoride levels. There was no evidence of unsightly fluorosis in the sample studied. PMID:23887535

  11. How trust in institutions and organizations builds general consumer confidence in the safety of food: a decomposition of effects.

    PubMed

    de Jonge, J; van Trijp, J C M; van der Lans, I A; Renes, R J; Frewer, L J

    2008-09-01

    This paper investigates the relationship between general consumer confidence in the safety of food and consumer trust in institutions and organizations. More specifically, using a decompositional regression analysis approach, the extent to which the strength of the relationship between trust and general confidence is dependent upon a particular food chain actor (for example, food manufacturers) is assessed. In addition, the impact of specific subdimensions of trust, such as openness, on consumer confidence are analyzed, as well as interaction effects of actors and subdimensions of trust. The results confirm previous findings, which indicate that a higher level of trust is associated with a higher level of confidence. However, the results from the current study extend on previous findings by disentangling the effects that determine the strength of this relationship into specific components associated with the different actors, the different trust dimensions, and specific combinations of actors and trust dimensions. The results show that trust in food manufacturers influences general confidence more than trust in other food chain actors, and that care is the most important trust dimension. However, the contribution of a particular trust dimension in enhancing general confidence is actor-specific, suggesting that different actors should focus on different trust dimensions when the purpose is to enhance consumer confidence in food safety. Implications for the development of communication strategies that are designed to regain or maintain consumer confidence in the safety of food are discussed. PMID:18450326

  12. Assessing low-activity faults for the seismic safety of dams

    SciTech Connect

    Page, W.D.; Savage, W.U.; McLaren, M.K.

    1995-12-31

    Dams have been a familiar construct in the northern Sierra Nevada range in California (north of the San Joaquin River) since the forty-niners and farmers diverted water to their gold mines and farms in the mid 19th century. Today, more than 370 dams dot the region from the Central Valley to the eastern escarpment. Fifty-five more dam streams on the eastern slope. The dams are of all types: 240 earth fill; 56 concrete gravity; 45 rock and earth fills; 35 rock fill; 14 concrete arch; 9 hydraulic fill; and 29 various other types. We use the northern Sierra Nevada to illustrate the assessment of low-activity faults for the seismic safety of dams. The approach, techniques, and methods of evaluation are applicable to other regions characterized by low seismicity and low-activity faults having long recurrence intervals. Even though several moderate earthquakes had shaken the Sierra Nevada since 1849 (for example, the 1875 magnitude 5.8 Honey Lake and the 1909 magnitudes 5 and 5.5 Downieville earthquakes), seismic analyses for dams in the area generally were not performed prior to the middle of this century. Following the 1971 magnitude 6.7 San Fernando earthquake, when the hydraulic-fill Lower Van Norman Dam in southern California narrowly escaped catastrophic failure, the California Division of Safety of Dams and the Federal Energy Regulatory Commission required seismic safety to be addressed with increasing rigor. In 1975, the magnitude 5.7 Oroville earthquake on the Cleveland Hill fault near Oroville Dam in the Sierra Nevada foothills, showed convincingly that earthquakes and surface faulting could occur within the range. Following this event, faults along the ancient Foothills fault system have been extensively investigated at dam sites.

  13. Emergent patterns from probabilistic generalizations of lateral activation and inhibition

    PubMed Central

    Kabla, Alexandre

    2016-01-01

    The combination of laterally activating and inhibiting feedbacks is well known to spontaneously generate spatial organization. It was introduced by Gierer and Meinhardt as an extension of Turing's great insight that two reacting and diffusing chemicals can spontaneously drive spatial morphogenesis per se. In this study, we develop an accessible nonlinear and discrete probabilistic model to study simple generalizations of lateral activation and inhibition. By doing so, we identify a range of modes of morphogenesis beyond the familiar Turing-type modes; notably, beyond stripes, hexagonal nets, pores and labyrinths, we identify labyrinthine highways, Kagome lattices, gyrating labyrinths and multi-colour travelling waves and spirals. The results are discussed within the context of Turing's original motivating interest: the mechanisms which underpin the morphogenesis of living organisms. PMID:27170648

  14. Analysis of general aviation single-pilot IFR incident data obtained from the NASA aviation safety reporting system

    NASA Technical Reports Server (NTRS)

    Bergeron, H. P.

    1980-01-01

    Data obtained from the NASA Aviation Safety Reporting System (ASRS) data base were used to determine problems in general aviation single pilot IFR operations. The data examined consisted of incident reports involving flight safety in the National Aviation System. Only those incidents involving general aviation fixed wing aircraft flying under IFR in instrument meteorological conditions were analyzed. The data were cataloged into one of five major problem areas: (1) controller judgement and response problems; (2) pilot judgement and response problems; (3) air traffic control intrafacility and interfacility conflicts; (4) ATC and pilot communications problems; and (5) IFR-VFR conflicts. The significance of the related problems, and the various underlying elements associated with each are discussed. Previous ASRS reports covering several areas of analysis are reviewed.

  15. 76 FR 33808 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-09

    ... Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477) or visit http..., titled ``Pipeline Safety: Public Awareness Program.'' PHMSA is preparing to request approval from OMB for... written comments, please include a self-addressed, stamped postcard with the following...

  16. 75 FR 13807 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477) or visit http... published in the Federal Register on July 2, 2009 (74 FR 31675) and comments were submitted to Docket No..., titled: Pipeline Safety: New Reporting Requirements for Hazardous Liquid Pipeline Operators:...

  17. 75 FR 73160 - Pipeline Safety: Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-29

    ...In accordance with the Paperwork Reduction Act of 1995, PHMSA invites comments on an information collection under Office of Management and Budget (OMB) Control No. 2137-0578, titled ``Reporting Safety-Related Conditions on Gas, Hazardous Liquid, and Carbon Dioxide Pipelines and Liquefied Natural Gas Facilities.'' PHMSA is preparing to request approval from OMB for a renewal of the current......

  18. Guidance for Safety Analysis of Other Than Nuclear Facilities/Activities at the INEEL

    SciTech Connect

    Swanson, Douglas Sidney; Perry, Scott William

    2002-06-01

    The U.S. Department of Energy Idaho Operations Office (DOE-ID) provided guidance per DOE-ID Orders 420.C, "Safety Basis Review and Approval Process," and 420.D, "Requirements and Guidance for Safety Analysis," for conducting safety analysis for facilities and activities that do not meet either the nuclear facility criteria or the criteria for not requiring additional safety analysis (NRASA). These facilities and activities are thus designated as "other than nuclear" (OTN), and hazard analyses are performed using a graded approach. This graded approach is done in accordance with DOE-ID Order 420.D. DOE-ID guidance is used to format these OTN facilities and activities into 3-chapter documents, rather than the 17-chapter format specified in DOE-STD-3009-94, "Preparation Guide for U.S. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports."

  19. Active Emergence from Propofol General Anesthesia is Induced by Methylphenidate

    PubMed Central

    Chemali, Jessica J.; Van Dort, Christa J.; Brown, Emery N.; Solt, Ken

    2012-01-01

    BACKGROUND A recent study showed that methylphenidate induces emergence from isoflurane general anesthesia. Isoflurane and propofol are general anesthetics that may have distinct molecular mechanisms of action. The objective of this study was to test the hypothesis that methylphenidate actively induces emergence from propofol general anesthesia. METHODS Using adult rats, the effect of methylphenidate on time to emergence after a single bolus of propofol was determined. The ability of methylphenidate to restore righting during a continuous target controlled infusion of propofol was also tested. In a separate group of rats, a target controlled infusion of propofol was established and spectral analysis was performed on electroencephalogram recordings taken before and after methylphenidate administration. RESULTS Methylphenidate decreased median time to emergence after a single dose of propofol from 735 seconds (95% CI: 598 to 897 seconds, n=6) to 448 seconds (95% CI: 371 to 495 seconds, n=6). The difference was statistically significant (p = 0.0051). During continuous propofol anesthesia with a median final target plasma concentration of 4.0 μg/ml (95%CI: 3.2 to 4.6, n=6), none of the rats exhibited purposeful movements after injection of normal saline. After methylphenidate, however, all 6 rats promptly exhibited arousal and had restoration of righting with a median time of 82 seconds (95% CI: 30 to 166 seconds). Spectral analysis of electroencephalogram data demonstrated a shift in peak power from delta (<4 Hz) to theta (4–8 Hz) and beta (12–30 Hz) after administration of methylphenidate, indicating arousal in 4/4 rats. CONCLUSIONS Methylphenidate decreases time to emergence after a single dose of propofol, and induces emergence during continuous propofol anesthesia in rats. Further study is warranted to test the hypothesis that methylphenidate induces emergence from propofol general anesthesia in humans. PMID:22446983

  20. Energy and Safety: Science Activities for Elementary Students, Level III (Grades (5-6).

    ERIC Educational Resources Information Center

    Westcott, Dale; And Others

    Thirteen activities are presented that focus on a common phenomenon of a child's world: energy. These activities relate energy, how it occurs, how it is used, and how to use it safely. Each activity includes the purpose, introduction, background, procedure, materials, estimated time for the activity, typical results, safety notes, and more ideas.…

  1. Energy and Safety: Science Activities for Elementary Students, Level I (Grades (K-2).

    ERIC Educational Resources Information Center

    Westcott, Dale; And Others

    Twelve activities are presented that focus on a common phenomenon of a child's world: energy. These activities relate energy, how it occurs, how it is used, and how to use it safely. Each activity includes the purpose, introduction, background, procedure, materials, estimated time for the activity, typical results, safety notes, and more ideas.…

  2. Energy and Safety: Science Activities for Elementary Students, Level II (Grades (3-4).

    ERIC Educational Resources Information Center

    Westcott, Dale; And Others

    Thirteen activities are presented that focus on a common phenomenon of a child's world: energy. These activities relate energy, how it occurs, how it is used, and how to use it safely. Each activity includes the purpose, introduction, background, procedure, materials, estimated time for the activity, typical results, safety notes, and more ideas.…

  3. 78 FR 10261 - Pipeline Safety: Information Collection Activities, Revision to Gas Distribution Annual Report

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-13

    ... Privacy Act Statement in the Federal Register published on April 11, 2000, (65 FR 19477) or visit http... TRANSPORTATION Pipeline and Hazardous Materials Safety Administration Pipeline Safety: Information Collection Activities, Revision to Gas Distribution Annual Report AGENCY: Pipeline and Hazardous Materials...

  4. 78 FR 50079 - Information Collection Activities: Safety and Environmental Management Systems (SEMS); Proposed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Bureau of Safety and Environmental Enforcement [Docket ID BSEE-2013-0005; OMB Control Number 1014-0017: 134E1700D2 EEEE500000 ET1SF0000.DAQ000] Information Collection Activities: Safety and Environmental Management Systems (SEMS); Proposed...

  5. A risk-based approach to cost-benefit analysis of software safety activities

    SciTech Connect

    Fortier, S.C. ); Michael, J.B. )

    1993-01-01

    Assumptions about the economics of making a system safe are usually not explicitly stated in industrial and software models of safety-critical systems. These assumptions span a wide spectrum of economic tradeoffs with respect to resources expended to make a system safe. The missing component in these models that is necessary for capturing the effect of economic tradeoffs is risk. A qualitative risk-based software safety model is proposed that combines features of industrial and software systems safety models. The risk-based model provides decision makers with a basis for performing cost-benefit analyses of software safety-related activities.

  6. A risk-based approach to cost-benefit analysis of software safety activities

    SciTech Connect

    Fortier, S.C.; Michael, J.B.

    1993-05-01

    Assumptions about the economics of making a system safe are usually not explicitly stated in industrial and software models of safety-critical systems. These assumptions span a wide spectrum of economic tradeoffs with respect to resources expended to make a system safe. The missing component in these models that is necessary for capturing the effect of economic tradeoffs is risk. A qualitative risk-based software safety model is proposed that combines features of industrial and software systems safety models. The risk-based model provides decision makers with a basis for performing cost-benefit analyses of software safety-related activities.

  7. EU Funded Research Activities on NPPS Operational Safety

    SciTech Connect

    Manolatos, P.; Van Goethem, G.

    2002-07-01

    The 5. framework programme (FP-5), the pluri-annual research programme of the European Union (EU), covers the period 1998-2002. Research on nuclear energy, fusion and fission, is covered by the EURATOM part of the FP-5. An overview of the Euratom's research on Nuclear Reactor Safety, managed by the DG-RTD of the European Commission (EC), is presented. This concerns 70 multi-partner projects of approximately euro 82.5 million total contract value that have been selected and co-financed during the period 1999-2001. They form the three clusters of projects dealing with the 'Operational Safety of Existing Installations'. 'Plant Life Extension and Management' (PLEM), 'Severe Accident Management' (SAM) and 'Evolutionary concepts' (EVOL). Emphasis is given here to the projects of the PLEM cluster. (authors)

  8. Changing remuneration systems: effects on activity in general practice.

    PubMed Central

    Krasnik, A; Groenewegen, P P; Pedersen, P A; von Scholten, P; Mooney, G; Gottschau, A; Flierman, H A; Damsgaard, M T

    1990-01-01

    OBJECTIVE--To investigate the effects on general practitioners' activities of a change in their remuneration from a capitation based system to a mixed fee per item and capitation based system. DESIGN--Follow up study with data collected from contact sheets completed by general practitioners in one period before (March 1987) a change in their remuneration system and two periods after (March 1988, November 1988), with a control group of general practitioners with a mixed fee per item and capitation based system throughout. SETTING--General practices in Copenhagen city (index group) and Copenhagen county (control group). SUBJECTS--265 General practitioners in Copenhagen city, of whom 100 were selected randomly from the 130 who agreed to participate (10 exclusions) and 326 general practitioners in Copenhagen county. MAIN OUTCOME MEASURES--Number of consultations (face to face and by telephone) and renewals of prescriptions, diagnostic and curative services, and specialist and hospital referrals per 1000 enlisted patients in one week. RESULTS--Of the 75 general practitioners who completed all three sheets, four were excluded for incomplete data. Total contact rates per 1000 patients listed rose significantly compared with the rates before the change index in the city (100.0 before the change v 111.7 (95% confidence interval 106.4 to 117.4 after the change) and over the same time in the control group (100.0 v 106.0), but within a year these rates fell (to 104.2(99.1 to 109.6) and 104.0 respectively). There was an increase in consultations by telephone initially but not thereafter. Rates of examinations and treatments that attracted specific additional remuneration after the change rose significantly compared with those before (diagnostic services, 138.1 (118.7 to 160.5) and 159.5 (137.8 to 184.7) and curative services 194.6 (152.2 to 248.9) and 194.8(152.3 to 249.2) for second and third data collections respectively) and with the control group (diagnostic services 105

  9. Analysis of general aviation single-pilot IFR incident data obtained from the NASA Aviation Safety Reporting System

    NASA Technical Reports Server (NTRS)

    Bergeron, H. P.

    1983-01-01

    An analysis of incident data obtained from the NASA Aviation Safety Reporting System (ASRS) has been made to determine the problem areas in general aviation single-pilot IFR (SPIFR) operations. The Aviation Safety Reporting System data base is a compilation of voluntary reports of incidents from any person who has observed or been involved in an occurrence which was believed to have posed a threat to flight safety. This paper examines only those reported incidents specifically related to general aviation single-pilot IFR operations. The frequency of occurrence of factors related to the incidents was the criterion used to define significant problem areas and, hence, to suggest where research is needed. The data was cataloged into one of five major problem areas: (1) controller judgment and response problems, (2) pilot judgment and response problems, (3) air traffic control (ATC) intrafacility and interfacility conflicts, (4) ATC and pilot communication problems, and (5) IFR-VFR conflicts. In addition, several points common to all or most of the problems were observed and reported. These included human error, communications, procedures and rules, and work load.

  10. Safety assessment of discharge chute isolation barrier preparation and installation activities. Revision 3

    SciTech Connect

    Meichle, R.H.

    1994-11-08

    This revision adds a section addressing impacts of dropping surfacing tool and rack cutter on the basin floor, and corrects typographical errors. The safety assessment is made for the activities for the preparation and installation of the discharge chute isolation barriers. The safety assessment includes a hazard assessment and comparisons of potential accidents/events to those addressed by the current safety basis documentation. No significant hazards were identified. An evaluation against the USQ evaluation questions was made and the determination made that the activities do not represent a USQ. Hazard categorization techniques were used to provide a basis for readiness review classifications.

  11. Personal Safety and the Healthy Hare Family Coloring & Activity Book for Grades 2-3.

    ERIC Educational Resources Information Center

    Ohio State Dept. of Health, Columbus.

    This activity and coloring booklet has been designed to supplement health lessons on safety issues for students in grades 2-3. Some of the activities are quite simple and require very little instruction and direction, while others are more difficult and require careful explanation prior to completion. The level of difficulty of the activities is…

  12. Missouri Secondary Science Safety Manual.

    ERIC Educational Resources Information Center

    Lemons, Judith L.

    The purpose of this safety manual is to provide a resource to help manage and minimize potential risks in science classrooms where students spend up to 60% of instructional time engaged in hands-on activities. This manual contains information on standards, legal aspects, and responsibilities for science safety; general laboratory safety for…

  13. A cross-sectional mixed methods study protocol to generate learning from patient safety incidents reported from general practice

    PubMed Central

    Carson-Stevens, Andrew; Hibbert, Peter; Avery, Anthony; Butlin, Amy; Carter, Ben; Cooper, Alison; Evans, Huw Prosser; Gibson, Russell; Luff, Donna; Makeham, Meredith; McEnhill, Paul; Panesar, Sukhmeet S; Parry, Gareth; Rees, Philippa; Shiels, Emma; Sheikh, Aziz; Ward, Hope Olivia; Williams, Huw; Wood, Fiona; Donaldson, Liam; Edwards, Adrian

    2015-01-01

    Introduction Incident reports contain descriptions of errors and harms that occurred during clinical care delivery. Few observational studies have characterised incidents from general practice, and none of these have been from the England and Wales National Reporting and Learning System. This study aims to describe incidents reported from a general practice care setting. Methods and analysis A general practice patient safety incident classification will be developed to characterise patient safety incidents. A weighted-random sample of 12 500 incidents describing no harm, low harm and moderate harm of patients, and all incidents describing severe harm and death of patients will be classified. Insights from exploratory descriptive statistics and thematic analysis will be combined to identify priority areas for future interventions. Ethics and dissemination The need for ethical approval was waivered by the Aneurin Bevan University Health Board research risk review committee given the anonymised nature of data (ABHB R&D Ref number: SA/410/13). The authors will submit the results of the study to relevant journals and undertake national and international oral presentations to researchers, clinicians and policymakers. PMID:26628526

  14. Safety, tolerability, pharmacokinetics, and efficacy of an interleukin-2 agonist among HIV-infected patients receiving highly active antiretroviral therapy.

    PubMed

    Davey, Richard T; Pertel, Peter E; Benson, Alice; Cassell, Delanie J; Gazzard, Brian G; Holodniy, Mark; Lalezari, Jacob P; Levy, Yves; Mitsuyasu, Ronald T; Palella, Frank J; Pollard, Richard B; Rajagopalan, Prabhu; Saag, Michael S; Salata, Robert A; Sha, Beverly E; Choudhri, Shurjeel

    2008-02-01

    We sought to determine the safety, maximum tolerated dose, optimal dose, and preliminary dose efficacy of intermittent subcutaneously (s.c.) administered BAY 50-4798 among patients with HIV infection receiving highly active antiretroviral therapy (HAART) compared with patients receiving HAART alone. A phase I/II randomized, double-blind, dose-escalation study was conducted of the safety, tolerability, pharmacokinetics, and efficacy of s.c. BAY 50-4798 administered to HIV-infected patients already receiving stable HAART. There were no unexpected safety findings in a population of HIV-infected patients receiving HAART plus SC BAY 50-4798 as adjunctive therapy. BAY 50-4798 exhibited nearly dose-proportional pharmacokinetics, and accumulation was minimal during multiple-dose treatment. Limited efficacy data indicated that treatment with BAY 50-4798 caused at least a transient increase in CD4(+) T cell counts in some recipients, particularly at the early time points. In general, this effect appeared to increase with increasing dose. Bay 50-4798 was generally well tolerated across the dose range tested, but a lack of potent, sustained immunologic activity suggests that further optimization of dose and schedule will be necessary. PMID:18279104

  15. Firefighter noise exposure during training activities and general equipment use.

    PubMed

    Root, Kyle S; Schwennker, Catherine; Autenrieth, Daniel; Sandfort, Delvin R; Lipsey, Tiffany; Brazile, William J

    2013-01-01

    Multiple noise measurements were taken on 6 types of fire station equipment and 15 types of emergency response vehicle-related equipment used by firefighters during routine and emergency operations at 10 fire stations. Five of the six types of fire station equipment, when measured at a distance of one meter and ear level, emitted noise equal to or greater than 85 dBA, including lawn maintenance equipment, snow blowers, compressors, and emergency alarms. Thirteen of 15 types of equipment located on the fire engines emitted noise levels equal to or greater than 85 dBA, including fans, saws, alarms, and extrication equipment. In addition, noise measurements were taken during fire engine operations, including the idling vehicle, vehicle sirens, and water pumps. Results indicated that idling fire-engine noise levels were below 85 dBA; however, during water pump and siren use, noise levels exceeded 85 dBA, in some instances, at different locations around the trucks where firefighters would be stationed during emergency operations. To determine if the duration and use of fire fighting equipment was sufficient to result in overexposures to noise during routine training activities, 93 firefighter personal noise dosimetry samples were taken during 10 firefighter training activities. Two training activities per sampling day were monitored during each sampling event, for a mean exposure time of 70 min per day. The noise dosimetry samples were grouped based on job description to compare noise exposures between the different categories of job tasks commonly associated with fire fighting. The three job categories were interior, exterior, and engineering. Mean personal dosimetry results indicated that the average noise exposure was 78 dBA during the training activities that lasted 70 min on average. There was no significant difference in noise exposure between each of the three job categories. Although firefighters routinely use equipment and emergency response vehicles that

  16. Generalized internal model robust control for active front steering intervention

    NASA Astrophysics Data System (ADS)

    Wu, Jian; Zhao, Youqun; Ji, Xuewu; Liu, Yahui; Zhang, Lipeng

    2015-03-01

    Because of the tire nonlinearity and vehicle's parameters' uncertainties, robust control methods based on the worst cases, such as H ∞, µ synthesis, have been widely used in active front steering control, however, in order to guarantee the stability of active front steering system (AFS) controller, the robust control is at the cost of performance so that the robust controller is a little conservative and has low performance for AFS control. In this paper, a generalized internal model robust control (GIMC) that can overcome the contradiction between performance and stability is used in the AFS control. In GIMC, the Youla parameterization is used in an improved way. And GIMC controller includes two sections: a high performance controller designed for the nominal vehicle model and a robust controller compensating the vehicle parameters' uncertainties and some external disturbances. Simulations of double lane change (DLC) maneuver and that of braking on split- µ road are conducted to compare the performance and stability of the GIMC control, the nominal performance PID controller and the H ∞ controller. Simulation results show that the high nominal performance PID controller will be unstable under some extreme situations because of large vehicle's parameters variations, H ∞ controller is conservative so that the performance is a little low, and only the GIMC controller overcomes the contradiction between performance and robustness, which can both ensure the stability of the AFS controller and guarantee the high performance of the AFS controller. Therefore, the GIMC method proposed for AFS can overcome some disadvantages of control methods used by current AFS system, that is, can solve the instability of PID or LQP control methods and the low performance of the standard H ∞ controller.

  17. General-purpose heat source project and space nuclear safety and fuels program. Progress reportt, January 1980

    SciTech Connect

    Maraman, W.J.

    1980-04-01

    This formal monthly report covers the studies related to the use of /sup 238/PuO/sub 2/ in radioisotopic power systems carried out for the Advanced Nuclear Systems and Projects Division of the Los Alamos Scientific Laboratory. The two programs involved are the general-purpose heat source development and space nuclear safety and fuels. Most of the studies discussed here are of a continuing nature. Results and conclusions described may change as the work continues. Published reference to the results cited in this report should not be made without the explicit permission of the person in charge of the work.

  18. Enhancing the NASA Expendable Launch Vehicle Payload Safety Review Process Through Program Activities

    NASA Technical Reports Server (NTRS)

    Palo, Thomas E.

    2007-01-01

    The safety review process for NASA spacecraft flown on Expendable Launch Vehicles (ELVs) has been guided by NASA-STD 8719.8, Expendable Launch Vehicle Payload Safety Review Process Standard. The standard focused primarily on the safety approval required to begin pre-launch processing at the launch site. Subsequent changes in the contractual, technical, and operational aspects of payload processing, combined with lessons-learned supported a need for the reassessment of the standard. This has resulted in the formation of a NASA ELV Payload Safety Program. This program has been working to address the programmatic issues that will enhance and supplement the existing process, while continuing to ensure the safety of ELV payload activities.

  19. Safety Is No Accident: Children's Activities in Injury Prevention.

    ERIC Educational Resources Information Center

    Kane, William M.; Herrera, Kathleen E.

    This book is one in the Children's Activity Series of books to promote awareness about health, family life, and cultural diversity for children in kindergarten through third grade. The books in this series are written to enhance an established curriculum, rather than to serve as the curriculum itself. They offer ideas for hands-on activities for…

  20. Association between overuse of mobile phones on quality of sleep and general health among occupational health and safety students.

    PubMed

    Eyvazlou, Meysam; Zarei, Esmaeil; Rahimi, Azin; Abazari, Malek

    2016-01-01

    Concerns about health problems due to the increasing use of mobile phones are growing. Excessive use of mobile phones can affect the quality of sleep as one of the important issues in the health literature and general health of people. Therefore, this study investigated the relationship between the excessive use of mobile phones and general health and quality of sleep on 450 Occupational Health and Safety (OH&S) students in five universities of medical sciences in the North East of Iran in 2014. To achieve this objective, special questionnaires that included Cell Phone Overuse Scale, Pittsburgh's Sleep Quality Index (PSQI) and General Health Questionnaire (GHQ) were used, respectively. In addition to descriptive statistical methods, independent t-test, Pearson correlation, analysis of variance (ANOVA) and multiple regression tests were performed. The results revealed that half of the students had a poor level of sleep quality and most of them were considered unhealthy. The Pearson correlation co-efficient indicated a significant association between the excessive use of mobile phones and the total score of general health and the quality of sleep. In addition, the results of the multiple regression showed that the excessive use of mobile phones has a significant relationship between each of the four subscales of general health and the quality of sleep. Furthermore, the results of the multivariate regression indicated that the quality of sleep has a simultaneous effect on each of the four scales of the general health. Overall, a simultaneous study of the effects of the mobile phones on the quality of sleep and the general health could be considered as a trigger to employ some intervention programs to improve their general health status, quality of sleep and consequently educational performance. PMID:26942630

  1. Safety enhancement of oil trunk pipeline crossing active faults on Sakhalin Island

    NASA Astrophysics Data System (ADS)

    Tishkina, E.; Antropova, N.; Korotchenko, T.

    2015-11-01

    The article explores the issues concerning safety enhancement of pipeline active fault crossing on Sakhalin Island. Based on the complexity and analysis results, all the faults crossed by pipeline system are classified into five categories - from very simple faults to extremely complex ones. The pipeline fault crossing design is developed in accordance with the fault category. To enhance pipeline safety at fault crossing, a set of methods should be applied: use of pipes of different safety classes and special trench design in accordance with soil permeability characteristics.

  2. 78 FR 58470 - General Technical, Organizational, and Conforming Amendments to the Federal Motor Carrier Safety...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-24

    ... (FR) on October 1, 2001 (66 FR 49867). The last sentence of paragraph (d)(1) is revised by... appendix on March 19, 2002 (67 FR 12715). In Section I titled, ``General,'' paragraph (c)(6), the reference..., which were incorrect in the original publication of the rule (66 FR 43103, August 17, 2001),...

  3. 78 FR 73863 - Public Availability of General Services Administration FY 2013 Federal Activities Inventory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-09

    ... ADMINISTRATION Public Availability of General Services Administration FY 2013 Federal Activities Inventory Reform (FAIR) Act Inventory AGENCY: General Services Administration (GSA). ACTION: Notice of public availability of FY 2013 Federal Activities Inventory Reform (FAIR) Act Inventory. SUMMARY: In accordance...

  4. 77 FR 54917 - Public Availability of General Services Administration FY 2012 Federal Activities Inventory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ... ADMINISTRATION Public Availability of General Services Administration FY 2012 Federal Activities Inventory Reform (FAIR) Act Inventory AGENCY: General Services Administration (GSA). ACTION: Notice of Public Availability of Fiscal Year (FY) 2012 Federal Activities Inventory Reform (FAIR) Act Inventory. SUMMARY:...

  5. Recent and Past Musical Activity Predicts Cognitive Aging Variability: Direct Comparison with General Lifestyle Activities

    PubMed Central

    Hanna-Pladdy, Brenda; Gajewski, Byron

    2012-01-01

    Studies evaluating the impact of modifiable lifestyle factors on cognition offer potential insights into sources of cognitive aging variability. Recently, we reported an association between extent of musical instrumental practice throughout the life span (greater than 10 years) on preserved cognitive functioning in advanced age. These findings raise the question of whether there are training-induced brain changes in musicians that can transfer to non-musical cognitive abilities to allow for compensation of age-related cognitive declines. However, because of the relationship between engagement in general lifestyle activities and preserved cognition, it remains unclear whether these findings are specifically driven by musical training or the types of individuals likely to engage in greater activities in general. The current study controlled for general activity level in evaluating cognition between musicians and nomusicians. Also, the timing of engagement (age of acquisition, past versus recent) was assessed in predictive models of successful cognitive aging. Seventy age and education matched older musicians (>10 years) and non-musicians (ages 59–80) were evaluated on neuropsychological tests and general lifestyle activities. Musicians scored higher on tests of phonemic fluency, verbal working memory, verbal immediate recall, visuospatial judgment, and motor dexterity, but did not differ in other general leisure activities. Partition analyses were conducted on significant cognitive measures to determine aspects of musical training predictive of enhanced cognition. The first partition analysis revealed education best predicted visuospatial functions in musicians, followed by recent musical engagement which offset low education. In the second partition analysis, early age of musical acquisition (<9 years) predicted enhanced verbal working memory in musicians, while analyses for other measures were not predictive. Recent and past musical activity, but not

  6. A review of significant events analysed in general practice: implications for the quality and safety of patient care

    PubMed Central

    McKay, John; Bradley, Nick; Lough, Murray; Bowie, Paul

    2009-01-01

    Background Significant event analysis (SEA) is promoted as a team-based approach to enhancing patient safety through reflective learning. Evidence of SEA participation is required for appraisal and contractual purposes in UK general practice. A voluntary educational model in the west of Scotland enables general practitioners (GPs) and doctors-in-training to submit SEA reports for feedback from trained peers. We reviewed reports to identify the range of safety issues analysed, learning needs raised and actions taken by GP teams. Method Content analysis of SEA reports submitted in an 18 month period between 2005 and 2007. Results 191 SEA reports were reviewed. 48 described patient harm (25.1%). A further 109 reports (57.1%) outlined circumstances that had the potential to cause patient harm. Individual 'error' was cited as the most common reason for event occurrence (32.5%). Learning opportunities were identified in 182 reports (95.3%) but were often non-specific professional issues not shared with the wider practice team. 154 SEA reports (80.1%) described actions taken to improve practice systems or professional behaviour. However, non-medical staff were less likely to be involved in the changes resulting from event analyses describing patient harm (p < 0.05) Conclusion The study provides some evidence of the potential of SEA to improve healthcare quality and safety. If applied rigorously, GP teams and doctors in training can use the technique to investigate and learn from a wide variety of quality issues including those resulting in patient harm. This leads to reported change but it is unclear if such improvement is sustained. PMID:19723325

  7. Parental physical activity, safety perceptions and children’s independent mobility

    PubMed Central

    2013-01-01

    Background Parents are likely to be a basic influence on their children's behavior. There is an absence of information about the associations between parents' physical activity and perception of neighborhood environment with children’s independent mobility. The purpose of this study is to examine the contribution of parental physical activity and perception of neighborhood safety to children’s independent mobility. Methods In this cross-sectional study of 354 pupils and their parents, independent mobility, perceptions of neighborhood safety and physical activity were evaluated by questionnaire. Categorical principal components analyses were used to determine the underlying dimensions of both independent mobility and perceptions of neighborhood safety items. Results The strongest predictor of independent mobility was the parental perception of sidewalk and street safety (ß = 0.132). Parent’s physical activity was also a significant predictor. The final model accounted for 13.0% of the variance. Conclusions Parental perception of neighborhood safety and parents’ self reported physical activity might be associated with children’s independent mobility. Further research in this topic is needed to explore this possible association. PMID:23767778

  8. The satiety signaling neuropeptide perisulfakinin inhibits the activity of central neurons promoting general activity.

    PubMed

    Wicher, Dieter; Derst, Christian; Gautier, Hélène; Lapied, Bruno; Heinemann, Stefan H; Agricola, Hans-Jürgen

    2007-01-01

    The metabolic state is one of the determinants of the general activity level. Satiety is related to resting or sleep whereas hunger correlates to wakefulness and activity. The counterpart to the mammalian satiety signal cholecystokinin (CCK) in insects are the sulfakinins. The aim of this study was to resolve the mechanism by which the antifeedant activity of perisulfakinin (PSK) in Periplaneta americana is mediated. We identified the sources of PSK which is used both as hormone and as paracrine messenger. PSK is found in the neurohemal organ of the brain and in nerve endings throughout the central nervous system. To correlate the distributions of PSK and its receptor (PSKR), we cloned the gene coding for PSKR and provide evidence for its expression within the nervous system. It occurs only in a few neurons, among them are the dorsal unpaired median (DUM) neurons which release octopamine thereby regulating the general level of activity. Application of PSK to DUM neurons attenuated the spiking frequency (EC(50)=11pM) due to reduction of a pacemaker Ca(2+) current through cAMP-inhibited pTRPgamma channels. PSK increased the intracellular cAMP level while decreasing the intracellular Ca(2+) concentration in DUM neurons. Thus, the satiety signal conferred by PSK acts antagonistically to the hunger signal, provided by the adipokinetic hormone (AKH): PSK depresses the electrical activity of DUM neurons by inhibiting the pTRPgamma channel that is activated by AKH under conditions of food shortage. PMID:18946521

  9. The Satiety Signaling Neuropeptide Perisulfakinin Inhibits the Activity of Central Neurons Promoting General Activity

    PubMed Central

    Wicher, Dieter; Derst, Christian; Gautier, Hélène; Lapied, Bruno; Heinemann, Stefan H.; Agricola, Hans-Jürgen

    2007-01-01

    The metabolic state is one of the determinants of the general activity level. Satiety is related to resting or sleep whereas hunger correlates to wakefulness and activity. The counterpart to the mammalian satiety signal cholecystokinin (CCK) in insects are the sulfakinins. The aim of this study was to resolve the mechanism by which the antifeedant activity of perisulfakinin (PSK) in Periplaneta americana is mediated. We identified the sources of PSK which is used both as hormone and as paracrine messenger. PSK is found in the neurohemal organ of the brain and in nerve endings throughout the central nervous system. To correlate the distributions of PSK and its receptor (PSKR), we cloned the gene coding for PSKR and provide evidence for its expression within the nervous system. It occurs only in a few neurons, among them are the dorsal unpaired median (DUM) neurons which release octopamine thereby regulating the general level of activity. Application of PSK to DUM neurons attenuated the spiking frequency (EC50=11pM) due to reduction of a pacemaker Ca2+ current through cAMP-inhibited pTRPγ channels. PSK increased the intracellular cAMP level while decreasing the intracellular Ca2+ concentration in DUM neurons. Thus, the satiety signal conferred by PSK acts antagonistically to the hunger signal, provided by the adipokinetic hormone (AKH): PSK depresses the electrical activity of DUM neurons by inhibiting the pTRPγ channel that is activated by AKH under conditions of food shortage. PMID:18946521

  10. Safety analysis of thorium-based fuels in the General Electric Standard BWR

    SciTech Connect

    Colby, M.J.; Townsend, D.B.; Kunz, C.L.

    1980-06-01

    A denatured (U-233/Th)O/sub 2/ fuel assembly has been designed which is energy equivalent to and hardware interchangeable with a modern boiling water reactor (BWR) reference reload assembly. Relative to the reference UO/sub 2/ fuel, the thorium fuel design shows better performance during normal and transient reactor operation for the BWR/6 product line and will meet or exceed current safety and licensing criteria. Power distributions are flattened and thermal operating margins are increased by reduced steam void reactivity coefficients caused by U-233. However, a (U-233/Th)O/sub 2/-fueled BWR will likely have reduced operating flexibility. A (U-235/Th)O/sub 2/-fueled BWR should perform similar to a UO/sub 2/-fueled BWR under all operating conditions. A (Pu/Th)O/sub 2/-fueled BWR may have reduced thermal margins and similar accident response and be less stable than a UO/sub 2/-fueled BWR. The assessment is based on comparisions of point model and infinite lattice predictions of various nuclear reactivity parameters, including void reactivity coefficients, Doppler reactivity coefficients, and control blade worths.

  11. Factors associated with the activities of safety representatives in Spanish workplaces

    PubMed Central

    García, Ana M; López‐Jacob, Maria José; Dudzinski, Isabel; Gadea, Rafael; Rodrigo, Fernando

    2007-01-01

    Objective To describe the activities of safety representatives in workplaces in Spain. Methods A specific questionnaire was applied to a representative sample of safety representatives. Activities developed during the past year, presented in a closed ended list, were categorised into three groups: information and advising; participation in occupational health management; and pressure on or negotiation with employers. Personal phone interviews were conducted from September to December 2004. A sample of 1201 interviews was attained. Crude and multivariate analyses were carried out. Results Spanish safety representatives were mostly men (76%), aged 26 to 45 years (62%), with fixed contracts (94%), and more than 10 years in their company (57%). On a comparable 0–10 scale, the mean (95% confidence interval (CI)) number of activities relating to information, management, and negotiation developed during the previous year were, respectively, 6.8 (6.7 to 6.9), 4.5 (4.4 to 4.7), and 4.0 (3.8 to 4.1). In multivariate analysis, workplace size (>30 workers), industrial sector, training, and support from the labour inspectorate were the factors most consistently associated with safety representatives' activity. Additionally, support from the employer was associated with participation in occupational health management (odds ratio = 2.38 (95% CI, 1.73 to 3.29)). Conclusions Safety representatives in Spain have a variety of activities, mostly in the category of information and advising. These are necessary but not sufficient for real participation of workers in decisions concerning their health and safety. More participation of safety representatives in occupational health management at workplaces seems to be needed, and factors associated with this participation reinforced. PMID:17699532

  12. DOE standard: Integration of environment, safety, and health into facility disposition activities. Volume 1: Technical standard

    SciTech Connect

    1998-05-01

    This Department of Energy (DOE) technical standard (referred to as the Standard) provides guidance for integrating and enhancing worker, public, and environmental protection during facility disposition activities. It provides environment, safety, and health (ES and H) guidance to supplement the project management requirements and associated guidelines contained within DOE O 430.1A, Life-Cycle Asset Management (LCAM), and amplified within the corresponding implementation guides. In addition, the Standard is designed to support an Integrated Safety Management System (ISMS), consistent with the guiding principles and core functions contained in DOE P 450.4, Safety Management System Policy, and discussed in DOE G 450.4-1, Integrated Safety Management System Guide. The ISMS guiding principles represent the fundamental policies that guide the safe accomplishment of work and include: (1) line management responsibility for safety; (2) clear roles and responsibilities; (3) competence commensurate with responsibilities; (4) balanced priorities; (5) identification of safety standards and requirements; (6) hazard controls tailored to work being performed; and (7) operations authorization. This Standard specifically addresses the implementation of the above ISMS principles four through seven, as applied to facility disposition activities.

  13. NASA safety program activities in support of the Space Exploration Initiatives Nuclear Propulsion program

    NASA Technical Reports Server (NTRS)

    Sawyer, J. C., Jr.

    1993-01-01

    The activities of the joint NASA/DOE/DOD Nuclear Propulsion Program Technical Panels have been used as the basis for the current development of safety policies and requirements for the Space Exploration Initiatives (SEI) Nuclear Propulsion Technology development program. The Safety Division of the NASA Office of Safety and Mission Quality has initiated efforts to develop policies for the safe use of nuclear propulsion in space through involvement in the joint agency Nuclear Safety Policy Working Group (NSPWG), encouraged expansion of the initial policy development into proposed programmatic requirements, and suggested further expansion into the overall risk assessment and risk management process for the NASA Exploration Program. Similar efforts are underway within the Department of Energy to ensure the safe development and testing of nuclear propulsion systems on Earth. This paper describes the NASA safety policy related to requirements for the design of systems that may operate where Earth re-entry is a possibility. The expected plan of action is to support and oversee activities related to the technology development of nuclear propulsion in space, and support the overall safety and risk management program being developed for the NASA Exploration Program.

  14. A new semi-active safety control strategy for high-speed railway vehicles

    NASA Astrophysics Data System (ADS)

    Guo, Jin; Xu, Zhengguo; Sun, Youxian

    2015-12-01

    This paper focuses on the safety of railway vehicles. A new semi-active control strategy is proposed based on the skyhook control theory. In view of the main railway vehicle safety performance indicators, the new control strategy aims at reducing the derailment coefficient of railway vehicles by restraining the lateral vibrations of the bogie and the wheelset. Furthermore, to evaluate the improvement of the safety performance brought about by the new control strategy, a complete railway vehicle model is established using the ADAMS/Rail software package. In further co-simulations, five conventional control methods are compared with the proposed approach under the same conditions. Co-simulation results indicate that the new control strategy is effective in improving the safety performance of railway vehicles.

  15. General-purpose heat source development: Safety verification test program. Titanium bullet/fragment test series

    NASA Astrophysics Data System (ADS)

    George, T. G.

    1986-06-01

    The radioisotope thermoelectric generator (RTG) that will provide power for the Galileo and Ulysses space missions contains 18 General-Purpose Heat Source (GPHS) modules. Each module contains four 238PuO2-fueled clads and generates 250 W(t). Because the possibility of launch-pad or postlaunch explosion exists and because any explosion would generate a field of high-energy fragments, the fueled clads within each GPHS module must be able to survive fragment impact. In this test series we investigated the response of bare, simulant-fueled (UO2) clads to the impact of high-energy titanium alloy fragments. We determined that 425m/s is the threshold impact velocity of a 3.25-g titanium bullet that will cause direct mechanical failure of a bare fueled clad.

  16. General-purpose heat source development: Safety Verification Test Program. Titanium bullet/fragment test series

    SciTech Connect

    George, T.G.

    1986-06-01

    The radioisotope thermoelectric generator (RTG) that will provide power for the Galileo and Ulysses space missions contains 18 General-Purpose Heat Source (GPHS) modules. Each module contains four /sup 238/PuO/sub 2/-fueled clads and generates 250 W(t). Because the possibility of launch-pad or postlaunch explosion exists and because any explosion would generate a field of high-energy fragments, the fueled clads within each GPHS module must be able to survive fragment impact. In this test series we investigated the response of bare, simulant-fueled (UO/sub 2/) clads to the impact of high-energy titanium alloy fragments. We determined that 425m/s is the threshold impact velocity of a 3.25-g titanium bullet that will cause direct mechanical failure of a bare fueled clad. 40 figs.

  17. General-Purpose Heat Source Development: safety test program. Postimpact evaluation, Design Iteration Test 1

    SciTech Connect

    Schonfeld, F.W.

    1984-04-01

    The General-Purpose Heat Source (GPHS) provides power for space missions by transmitting the heat of /sup 238/PuO/sub 2/ decay to thermoelectric elements. Because of the inevitable return of certain missions, the heat source must be designed and constructed to survive re-entry and Earth impact. The Design Iteration Test (DIT) series is part of an ongoing impact test program. The first DIT used a full GPHS module containing two graphite impact shells (GISs); each GIS contained two iridium (0.3 wt%) capsules filled with /sup 238/PuO/sub 2/. It was impacted at 57 m/s and 930/sup 0/C. All four fuel capsules survived and none was breached. However, serious cracking of the iridium-alloy capsules was found; some cracks extended through approx. 70% of the wall thickness. Postimpact analyses of the unit are described with emphasis on weld structure and performance. 51 figures.

  18. [Safety problems of occupational activity during alcoholic intoxication].

    PubMed

    Ushakov, I B; Popov, V I

    1999-01-01

    It has been established that work efficiency of persons occupied by machine operating duties degrades markedly under the action of an acute alcoholic intoxication--less on real machines and more on simulators and when operating simple technical devices. Work efficiency degradation is manifested by the task execution time increase (to a lesser degree) and by erroneous action quantity increase after taking alcohol, i.e. by work reliability decease. Most heavily it is manifested during the first 0.7-1.5 hr. After taking alcohol. And direct work efficiency index is usually improved 12-16 hr. after taking alcohol. Increase of erroneous action quantity is caused probably by a series of physiological, psychophysiological and psychological changes in the condition of a man under the action of alcohol. Time of the day when the activity takes place after taking that dose of alcohol is practically non valid for changing work efficiency index. PMID:11965736

  19. Clinical efficacy and safety of fluoxetine in generalized anxiety disorder in Chinese patients

    PubMed Central

    Zou, Chuan; Ding, Xiang; Flaherty, Joseph H; Dong, Birong

    2013-01-01

    Background Generalized anxiety disorder (GAD) is a prevalent, disabling disease and is highly comorbid with other psychiatric disorders both in Western countries and the People’s Republic of China. Fluoxetine, a selective inhibitor of serotonin reuptake (SSRI), is widely utilized in the management of GAD in clinical practice despite the lack of strong evidence. This article reviews fluoxetine trials to investigate fluoxetine’s efficacy and tolerability in Chinese patients with GAD. Methods A literature review was conducted using the following databases up to and including April 2013: Chinese BioMedical Literature, China National Knowledge Infrastructure, EMBASE, MEDLINE, and PsycINFO. We selected clinical studies that utilized fluoxetine for GAD in which all participants were Chinese. Results Fifteen open-label, non-placebo trials were identified and analyzed; eleven anxiolytics were compared with fluoxetine separately. Short-term efficacy of fluoxetine had been established in these open-label, head-to-head controlled trials. Fluoxetine had rapid onset of action (approximately 1–2 weeks) and seemed to be effective in maintenance treatment. Fluoxetine was generally well-tolerated with the most common side effect of dry month and nausea. Compared to other anxiolytic agents, fluoxetine was equivalent with all of the comparative anxiolytics in terms of efficacy except mirtazapine which showed conflicting results with fluoxetine in two studies. In terms of side effects, fluoxetine was better tolerated than diazepam, doxepine, and amitriptyline, less tolerated than escitalopram, and had similar tolerability with duloxetine as well as alprazolam. Conclusion Given the high risk of bias of the included studies, the overall small sample size of the studies, the lack of placebo control groups as well as the lack of certain clinically meaningful outcomes, it is not possible to recommend fluoxetine as a reliable first-line treatment in Chinese patients with GAD

  20. Guide for preparing annual reports on radiation-safety testing of electronic products (general)

    SciTech Connect

    Not Available

    1987-10-01

    For manufacturers of electronic products other than those for which a specific guide has been issued, the guide replaces the Guide for the Filing of Annual Reports (21 CFR Subchapter J, Section 1002.11), HHS Publication FDA 82-8127. The electronic product (general) annual reporting guide is applicable to the following products: products intended to produce x radiation (accelerators, analytical devices, therapy x-ray machines); microwave diathermy machines; cold-cathode discharge tubes; and vacuum switches and tubes operating at or above 15,000 volts. To carry out its responsibilities under Public Law 90-602, the Food and Drug Administration's Center for Devices and Radiological Health (CDRH) has issued a series of regulations contained in Title 21 of the Code of Federal Regulations (CFR). Part 1002 of 21 CFR deals with records and reports. Section 1002.61 categorizes electronic products into Groups A through C. Section 1002.30 requires manufacturers of products in Groups B and C to establish and maintain certain records, while Section 1002.11 requires such manufacturers to submit an Annual Report summarizing the contents of the required records. Section 1002.7 requires that reports conform to reporting guides issued by CDRH unless an acceptable justification for an alternate format is provided.

  1. Rewarding safety belt usage at an industrial setting: Tests of treatment generality and response maintenance

    PubMed Central

    Geller, E. Scott

    1983-01-01

    An incentive program to motivate seat belt use was implemented at a large munitions plant. Seat belt usage was assessed daily at an entrance/exit gate of the industrial complex when employees arrived for work in the morning and departed in the afternoon. During treatment incentive fliers, which prompted seat belt usage and gave belt wearers opportunities to win prizes, were distributed only in the afternoon. Seat belt wearing increased from baseline means of 20.4% and 17.3% during the morning and afternoon, respectively, to averages of 55.5% during afternoon departures and 31.1% during morning arrivals. During follow-up, mean belt use dropped almost to baseline levels. Categorizing vehicles according to driver sex and license plate number enabled a study of belt wearing practices of individuals, and revealed that the incentive program influenced some drivers to wear their seat belts during morning arrival when incentives were not distributed (i.e., treatment generalization) and during a follow-up period after the incentives were withdrawn (i.e., response maintenance). PMID:16795663

  2. General-Purpose Heat Source development: safety test program. Postimpact evaluation, Design Iteration Test 2

    SciTech Connect

    Schonfeld, F.W.; George, T.G.

    1984-06-01

    The General-Purpose Heat Source (GPHS) provides power for space missions by transmitting the heat of /sup 238/PuO/sub 2/ decay to thermoelectric elements. Because of the inevitable return of certain missions, the heat source must be Designed and constructed to survive both re-entry and Earth impact. The Design Iteration Test (DIT) series is part of an ongoing test program. In the first Design Iteration Test (DIT-1), a full GPHS module ontaining four iridium-alloy capsules loaded with /sup 238/PuO/sub 2/ was impacted at 57 m/s and 930/sup 0/C. All four capsules survived and none was breached. The capsules used in DIT-1 were loaded and welded at Los Alamos. The second Design Iteration Test (DIT-2) also used a full GPHS module and was impacted at 58 m/s and 930/sup 0/C. The four iridium-alloy capsules used in this test were loaded and welded at the Savannah River Plant (SRP). Postimpact examination revealed that two capsules had survived and two capsules had breached; a small quantity (approx. = 50 ..mu..g) of /sup 238/PuO/sub 2/ was released from the breached capsules. Internal cracking similar to that observed in the DIT-1 capsules was evident in all four of the DIT-2 capsules. Postimpact analyses of the units are described with emphasis on weld structure and performance.

  3. Taking ownership of safety. What are the active ingredients of safety coaching and how do they impact safety outcomes in critical offshore working environments?

    PubMed

    Krauesslar, Victoria; Avery, Rachel E; Passmore, Jonathan

    2015-01-01

    Safety coaching interventions have become a common feature in the safety critical offshore working environments of the North Sea. Whilst the beneficial impact of coaching as an organizational tool has been evidenced, there remains a question specifically over the use of safety coaching and its impact on behavioural change and producing safe working practices. A series of 24 semi-structured interviews were conducted with three groups of experts in the offshore industry: safety coaches, offshore managers and HSE directors. Using a thematic analysis approach, several significant themes were identified across the three expert groups including connecting with and creating safety ownership in the individual, personal significance and humanisation, ingraining safety and assessing and measuring a safety coach's competence. Results suggest clear utility of safety coaching when applied by safety coaches with appropriate coach training and understanding of safety issues in an offshore environment. The current work has found that the use of safety coaching in the safety critical offshore oil and gas industry is a powerful tool in managing and promoting a culture of safety and care. PMID:26327261

  4. Generalized Event Knowledge Activation during Online Sentence Comprehension

    ERIC Educational Resources Information Center

    Metusalem, Ross; Kutas, Marta; Urbach, Thomas P.; Hare, Mary; McRae, Ken; Elman, Jeffrey L.

    2012-01-01

    Recent research has demonstrated that knowledge of real-world events plays an important role in guiding online language comprehension. The present study addresses the scope of event knowledge activation during the course of comprehension, specifically investigating whether activation is limited to those knowledge elements that align with the local…

  5. IFLA General Conference, 1985. Division on Regional Activities. Papers.

    ERIC Educational Resources Information Center

    International Federation of Library Associations, The Hague (Netherlands).

    Papers on regional library activities which were presented at the 1985 International Federation of Library Associations (IFLA) conference include: (1) "Importance of Information Resources in National Development with Particular Reference to the Asian Scene" (Yogendra P. Dubey, India); (2) "Report of the Activities of the Regional Section for Asia…

  6. Technology, Active Learning, and Retention in General Education Mathematics

    ERIC Educational Resources Information Center

    Levi, Inessa; Chahine, Iman; Garrett, Lauretta; Wang, Haifeng

    2016-01-01

    Difficulties in general education mathematics courses may be attributed to many factors, primarily low proficiency in symbol manipulation, a perception that mathematics is an area which eludes mastery, a lack of engagement and effective practice. Educational technology can be a powerful aid in overcoming these factors. This work describes the…

  7. Nuclear Data Activities in Support of the DOE Nuclear Criticality Safety Program

    SciTech Connect

    Westfall, R.M.; McKnight, R.D.

    2005-05-24

    The DOE Nuclear Criticality Safety Program (NCSP) provides the technical infrastructure maintenance for those technologies applied in the evaluation and performance of safe fissionable-material operations in the DOE complex. These technologies include an Analytical Methods element for neutron transport as well as the development of sensitivity/uncertainty methods, the performance of Critical Experiments, evaluation and qualification of experiments as Benchmarks, and a comprehensive Nuclear Data program coordinated by the NCSP Nuclear Data Advisory Group (NDAG).The NDAG gathers and evaluates differential and integral nuclear data, identifies deficiencies, and recommends priorities on meeting DOE criticality safety needs to the NCSP Criticality Safety Support Group (CSSG). Then the NDAG identifies the required resources and unique capabilities for meeting these needs, not only for performing measurements but also for data evaluation with nuclear model codes as well as for data processing for criticality safety applications. The NDAG coordinates effort with the leadership of the National Nuclear Data Center, the Cross Section Evaluation Working Group (CSEWG), and the Working Party on International Evaluation Cooperation (WPEC) of the OECD/NEA Nuclear Science Committee. The overall objective is to expedite the issuance of new data and methods to the DOE criticality safety user. This paper describes these activities in detail, with examples based upon special studies being performed in support of criticality safety for a variety of DOE operations.

  8. Condoms and Contexts: Profiles of Sexual Risk and Safety Among Young Heterosexually Active Men

    PubMed Central

    Masters, N. Tatiana; Casey, Erin; Beadnell, Blair; Morrison, Diane M.; Hoppe, Marilyn J.; Wells, Elizabeth A.

    2014-01-01

    Heterosexual men’s sexual safety behavior is important to controlling the U.S. epidemic of sexually transmitted infections (STIs), including HIV. While sexual safety is often treated as a single behavior, such as condom use, it can also be conceptualized as resulting from multiple factors. Doing so can help us achieve more nuanced understandings of sexual risk and safety within partner-related contexts. We used Latent Class Analysis with data collected online from 18-25 year old heterosexually active U.S. men (n = 432) to empirically derive a typology of the patterns of sexual safety strategies they employ. Indicators were sexual risk reduction strategies used in the past year with the most recent female sex partner: Condom use, discussing sexual histories, STI testing, agreeing to be monogamous, and discussing birth control. We identified four subgroups: Risk Takers (12%), Condom Reliers (25%), Multistrategists (28%), and Relationship Reliers (35%). Partner-related context factors – number of past-year sex partners, relationship commitment, and sexual concurrency – predicted subgroup membership. Findings support tailoring STI prevention to men’s sexual risk-safety subgroups. Interventions should certainly continue to encourage condom use, but should also include information on how partner-related context factors and alternate sexual safety strategies can help men reduce risk for themselves and their partners. PMID:25256019

  9. Heat-activated cooling devices: A guidebook for general audiences

    SciTech Connect

    Wiltsee, G.

    1994-02-01

    Heat-activated cooling is refrigeration or air conditioning driven by heat instead of electricity. A mill or processing facility can us its waste fuel to air condition its offices or plant; using waste fuel in this way can save money. The four basic types of heat-activated cooling systems available today are absorption cycle, desiccant system, steam jet ejector, and steam turbine drive. Each is discussed, along with cool storage and biomass boilers. Steps in determining the feasibility of heat-activated cooling are discussed, as are biomass conversion, system cost and integration, permits, and contractor selection. Case studies are given.

  10. 77 FR 58608 - Railroad Safety Advisory Committee (RSAC); Working Group Activity Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-21

    ... (77 FR 55372), with comments due by November 6, 2012. No additional System Safety Task Group meetings... announcement of working group activities and status reports of April 23, 2012 (77 FR 24257). The 46th full RSAC... published on August 24, 2006 (71 FR 50275), and was open for comment until October 23, 2006. The...

  11. 75 FR 76070 - Railroad Safety Advisory Committee (RSAC); Working Group Activity Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... (Railroad Bridge Safety Assurance) regarding bridge failure. Final rule published on July 15, 2010 (75 FR... announcement of working group activities and status reports of August 20, 2010 (75 FR 51525). The 42nd full... Rulemaking (NPRM) was published on August 24, 2006 (71 FR 50275), and was open for comment until October...

  12. T & I--Building Construction, Safety. Kit No. 1. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Howard, John

    An instructor's manual and student activity guide on building construction safety are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture,…

  13. Safety basis For activities in double-shell tanks with flammable gas concerns

    SciTech Connect

    Schlosser, R.L.

    1996-02-05

    This is full revision to Revision 0 of this report. The purpose of this report is to provide a summary of analyses done to support activities performed for double shell tanks. These activities are encompassed by the flammable gas Unreviewed Safety Question (USQ). The basic controls required to perform these activities involve the identification, elimination and/or control of ignition sources and monitoring for flammable gases. Controls are implemented through the Interim Safety Basis (ISB), IOSRs, and OSDs. Since this report only provides a historical compendium of issues and activities, it is not to be used as a basis to perform USQ screenings and evaluations. Furthermore, these analyses and others in process will be used as the basis for developing the Flammable Gas Topical Report for the ISB Upgrade.

  14. Safety basis for selected activities in single-shell tanks with flammable gas concerns. Revision 1

    SciTech Connect

    Schlosser, R.L.

    1996-02-05

    This is full revision to Revision 0 of this report. The purpose of this report is to provide a summary of analyses done to support activities performed for single-shell tanks. These activities are encompassed by the flammable gas Unreviewed Safety Question (USQ). The basic controls required to perform these activities involve the identification, elimination and/or control of ignition sources and monitoring for flammable gases. Controls are implemented through the Interim Safety Basis (ISB), IOSRs, and OSDs. Since this report only provides a historical compendium of issues and activities, it is not to be used as a basis to perform USQ screenings and evaluations. Furthermore, these analyses and others in process will be used as the basis for developing the Flammable Gas Topical Report for the ISB Upgrade.

  15. 78 FR 48660 - Agency Information Collection Activities; Comment Request; Student Assistance General Provisions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... Agency Information Collection Activities; Comment Request; Student Assistance General Provisions--Subpart K--Cash Management AGENCY: Federal Student Aid (FSA), Department of Education (ED). ACTION: Notice... notice will be considered public records. Title of Collection: Student Assistance General...

  16. 78 FR 63972 - Agency Information Collection Activities; Comment Request; Student Assistance General Provisions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... Agency Information Collection Activities; Comment Request; Student Assistance General Provisions AGENCY: Federal Student Aid (FSA), Department of Education (ED). ACTION: Notice. SUMMARY: In accordance with the... considered public records. Title of Collection: Student Assistance General Provisions. OMB Control...

  17. Spatio-temporal elements of articulation work in the achievement of repeat prescribing safety in UK general practice.

    PubMed

    Grant, Suzanne; Mesman, Jessica; Guthrie, Bruce

    2016-02-01

    Prescribing is the most common healthcare intervention, and is both beneficial and risky. An important source of risk in UK general practice is the management of 'repeat prescriptions', which are typically requested from and issued by non-clinically trained reception staff with only intermittent reauthorisation by a clinical prescriber. This paper ethnographically examines the formal and informal work employed by GPs and receptionists to safely conduct repeat prescribing work in primary care using Strauss's (1985, 1988, 1993) concept of 'articulation work' across eight UK general practices. The analytical lens of articulation work provided an investigative framing to contextually map the informal, invisible resources of resilience and strength employed by practice team members in the achievement of repeat prescribing safety, where risk and vulnerability were continually relocated across space and time. In particular, the paper makes visible the micro-level competencies and collaborative practices that were routinely employed by both GPs and receptionists across different socio-cultural contexts, with informal, cross-hierarchical communication usually considered more effective than the formal structures of communication that existed (e.g. protocols). While GPs held formal prescribing authority, this paper also examines the key role of receptionists in both the initiation and safe coordination of the repeat prescribing routine. PMID:26283462

  18. Examining variations in prescribing safety in UK general practice: cross sectional study using the Clinical Practice Research Datalink

    PubMed Central

    Kontopantelis, Evangelos; Akbarov, Artur; Rodgers, Sarah; Avery, Anthony J; Ashcroft, Darren M

    2015-01-01

    Study question What is the prevalence of different types of potentially hazardous prescribing in general practice in the United Kingdom, and what is the variation between practices? Methods A cross sectional study included all adult patients potentially at risk of a prescribing or monitoring error defined by a combination of diagnoses and prescriptions in 526 general practices contributing to the Clinical Practice Research Datalink (CPRD) up to 1 April 2013. Primary outcomes were the prevalence of potentially hazardous prescriptions of anticoagulants, anti-platelets, NSAIDs, β blockers, glitazones, metformin, digoxin, antipsychotics, combined hormonal contraceptives, and oestrogens and monitoring by blood test less frequently than recommended for patients with repeated prescriptions of angiotensin converting enzyme inhibitors and loop diuretics, amiodarone, methotrexate, lithium, or warfarin. Study answer and limitations 49 927 of 949 552 patients at risk triggered at least one prescribing indicator (5.26%, 95% confidence interval 5.21% to 5.30%) and 21 501 of 182 721 (11.8%, 11.6% to 11.9%) triggered at least one monitoring indicator. The prevalence of different types of potentially hazardous prescribing ranged from almost zero to 10.2%, and for inadequate monitoring ranged from 10.4% to 41.9%. Older patients and those prescribed multiple repeat medications had significantly higher risks of triggering a prescribing indicator whereas younger patients with fewer repeat prescriptions had significantly higher risk of triggering a monitoring indicator. There was high variation between practices for some indicators. Though prescribing safety indicators describe prescribing patterns that can increase the risk of harm to the patient and should generally be avoided, there will always be exceptions where the indicator is clinically justified. Furthermore there is the possibility that some information is not captured by CPRD for some practices—for example, INR results in

  19. Annual Report To Congress. Department of Energy Activities Relating to the Defense Nuclear Facilities Safety Board, Calendar Year 2003

    SciTech Connect

    None, None

    2004-02-28

    The Department of Energy (Department) submits an Annual Report to Congress each year detailing the Department’s activities relating to the Defense Nuclear Facilities Safety Board (Board), which provides advice and recommendations to the Secretary of Energy (Secretary) regarding public health and safety issues at the Department’s defense nuclear facilities. In 2003, the Department continued ongoing activities to resolve issues identified by the Board in formal recommendations and correspondence, staff issue reports pertaining to Department facilities, and public meetings and briefings. Additionally, the Department is implementing several key safety initiatives to address and prevent safety issues: safety culture and review of the Columbia accident investigation; risk reduction through stabilization of excess nuclear materials; the Facility Representative Program; independent oversight and performance assurance; the Federal Technical Capability Program (FTCP); executive safety initiatives; and quality assurance activities. The following summarizes the key activities addressed in this Annual Report.

  20. IFLA General Conference, 1987. Division of Regional Activities. Papers.

    ERIC Educational Resources Information Center

    International Federation of Library Associations, The Hague (Netherlands).

    Six of the seven papers in this collection focus on regional library activities in Africa, Asia and Oceania, and Latin America and the Caribbean: (1) "Libraries and Information Services in a Changing World: The Challenges African Information Services Face at the End of the 1980s" (Dejen Abate, Ethiopia); (2) "The Computer and Knowledge Information…

  1. 20 CFR 220.142 - General information about work activity.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... the claimant does his or her work satisfactorily, this may show that the claimant is working at the substantial gainful activity level. If the claimant is unable, because of his or her impairments, to do... level. (b) How well the claimant performs. The Board considers how well the claimant does his or...

  2. 20 CFR 220.142 - General information about work activity.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... the claimant does his or her work satisfactorily, this may show that the claimant is working at the substantial gainful activity level. If the claimant is unable, because of his or her impairments, to do... level. (b) How well the claimant performs. The Board considers how well the claimant does his or...

  3. 20 CFR 220.142 - General information about work activity.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... the claimant does his or her work satisfactorily, this may show that the claimant is working at the substantial gainful activity level. If the claimant is unable, because of his or her impairments, to do... level. (b) How well the claimant performs. The Board considers how well the claimant does his or...

  4. Lessons learned from Fukushima Daiichi nuclear power plant accident: efficient education items of radiation safety for general public.

    PubMed

    Ohno, K; Endo, K

    2015-07-01

    The Fukushima Daiichi nuclear power plant (FNP-1) accident, while as tragic as the tsunami, was a man-made disaster created by the ignorance of the effects of radiation and radioactive materials. Therefore, it is important that all specialists in radiation protection in medicine sympathize with the anxiety of the general public regarding the harmful effects of radiation and advise people accordingly. All questions and answers were collected related to inquiries from the general public that were posted to reliable websites, including those of the government and radiation-related organizations, from March 2011 to November 2012. The questions were summarized and classified by similarity of content. (1) The total number of questions is 372. The content was broadly classified into three categories: inquiries for radiation-related knowledge and about health effects and foods. The questions asked to obtain radiation-related knowledge were the most common, accounting for 38 %. Thirty-six percentage of the questions were related to health effects, and 26 % involved foods, whereas 18 % of the questions were related to children and pregnancy. (2) The change over time was investigated in 290 questions for which the time of inquiry was known. Directly after the earthquake, the questions were primarily from people seeking radiation-related knowledge. Later, questions related to health effects increased. The anxiety experienced by residents following the nuclear accident was caused primarily by insufficient knowledge related to radiation, concerns about health effects and uncertainties about food and water safety. The development of educational materials focusing on such content will be important for risk communication with the general public in countries with nuclear power plants. Physicians and medical physicist should possess the ability to respond to questions such as these and should continue with medical examinations and treatments in a safe and appropriate manner. PMID

  5. Age-Related Declines in General Cognitive Abilities of Balb/C Mice and General Activity Are Associated with Disparities in Working Memory, Body Weight, and General Activity

    ERIC Educational Resources Information Center

    Matzel, Louis D.; Grossman, Henya; Light, Kenneth; Townsend, David; Kolata, Stefan

    2008-01-01

    A defining characteristic of age-related cognitive decline is a deficit in general cognitive performance. Here we use a testing and analysis regimen that allows us to characterize the general learning abilities of young (3-5 mo old) and aged (19-21 mo old) male and female Balb/C mice. Animals' performance was assessed on a battery of seven diverse…

  6. The Activities of the International Criticality Safety Benchmark Evaluation Project (ICSBEP)

    SciTech Connect

    Briggs, Joseph Blair

    2001-10-01

    The International Criticality Safety Benchmark Evaluation Project (ICSBEP) was initiated in 1992 by the United States Department of Energy. The ICSBEP became an official activity of the Organization for Economic Cooperation and Development (OECD) – Nuclear Energy Agency (NEA) in 1995. Representatives from the United States, United Kingdom, France, Japan, the Russian Federation, Hungary, Republic of Korea, Slovenia, Yugoslavia, Kazakhstan, Spain, and Israel are now participating. The purpose of the ICSBEP is to identify, evaluate, verify, and formally document a comprehensive and internationally peer-reviewed set of criticality safety benchmark data. The work of the ICSBEP is published as an OECD handbook entitled “International Handbook of Evaluated Criticality Safety Benchmark Experiments”. The 2001 Edition of the Handbook contains benchmark specifications for 2642 critical or subcritical configurations that are intended for use in validation efforts and for testing basic nuclear data.

  7. Development and Testing of a Nutrition, Food Safety, and Physical Activity Checklist for EFNEP and FSNE Adult Programs

    ERIC Educational Resources Information Center

    Bradford, Traliece; Serrano, Elena L.; Cox, Ruby H.; Lambur, Michael

    2010-01-01

    Objective: To develop and assess reliability and validity of the Nutrition, Food Safety, and Physical Activity Checklist to measure nutrition, food safety, and physical activity practices among adult Expanded Food and Nutrition Education Program (EFNEP) and Food Stamp Nutrition Education program (FSNE) participants. Methods: Test-retest…

  8. The Activity Centres (Young Persons' Safety) Act 1995, the Adventure Activities Licensing Regulations 1996.

    ERIC Educational Resources Information Center

    Journal of Adventure Education and Outdoor Leadership, 1996

    1996-01-01

    Explains licensing regulations applicable in the United Kingdom to commercial providers of adventure education programs that offer caving, climbing, trekking, and water sports; provides information on license applications, including licensing standards related to risk assessment and safety management procedures; and addresses issues related to the…

  9. 75 FR 78725 - Recreational Boating Safety Projects, Programs and Activities Funded Under Provisions of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-16

    ... Responsibly!'', Life Jacket Wear, Vessel Safety Check Program (VSC), Boating Safety Education Courses..., during classroom instruction, and during Vessel Safety Checks. ($101,420). Reimbursable Salaries:...

  10. The efficacy and safety of multiple doses of vortioxetine for generalized anxiety disorder: a meta-analysis

    PubMed Central

    Fu, Jie; Peng, Lilei; Li, Xiaogang

    2016-01-01

    Objective Vortioxetine is a novel antidepressant approved for the treatment of major depressive disorder by the US Food and Drug Administration in September 2013. This meta-analysis assessed the efficacy and safety of different doses of vortioxetine for generalized anxiety disorder of adults. Methods PubMed, Cochrane Library, PsycINFO, and Clinical Trials databases were searched from 2000 through 2015. The abstracts of the annual meetings of the American Psychiatric Association and previous reviews were searched to identify additional studies. The search was limited to individual randomized controlled trials (RCTs), and there was no language restriction. Four RCTs met the selection criteria. These studies included 1,843 adult patients. Results were expressed as odds ratios (ORs) and 95% confidence intervals (CIs). The data were pooled with a random-effects or fixed-effects model. Results The results showed that multiple doses (2.5, 5, and 10 mg/d) of vortioxetine did not significantly improve the generalized anxiety disorder symptoms compared to placebo (OR=1.16, 95% CI=0.84–1.60, Z=0.89, P=0.38; OR=1.41, 95% CI=0.82–2.41, Z=1.25, P=0.21; OR=1.05, 95% CI=0.76–1.46, Z=0.32, P=0.75, respectively). We measured the efficacy of 2.5 mg/d vortioxetine compared to 10 mg/d, and no significant differences were observed. The common adverse effects included nausea and headache. With increased dose, nausea was found to be more frequent in the vortioxetine (5 and 10 mg/d) group (OR=2.99, 95% CI=1.31–6.84, Z=2.60, P=0.009; OR=2.80, 95% CI=1.85–4.25, Z=4.85, P<0.00001, respectively), but no significant differences were observed for headache. Conclusion The results showed no significant improvement in the treatment of generalized anxiety disorder for vortioxetine compared to placebo, and nausea was more frequent with higher doses. So the current evidences do not support using vortioxetine for the treatment of generalized anxiety disorder. Few RCTs were included in our

  11. Handling and safety enhancement of race cars using active aerodynamic systems

    NASA Astrophysics Data System (ADS)

    Diba, Fereydoon; Barari, Ahmad; Esmailzadeh, Ebrahim

    2014-09-01

    A methodology is presented in this work that employs the active inverted wings to enhance the road holding by increasing the downward force on the tyres. In the proposed active system, the angles of attack of the vehicle's wings are adjusted by using a real-time controller to increase the road holding and hence improve the vehicle handling. The handling of the race car and safety of the driver are two important concerns in the design of race cars. The handling of a vehicle depends on the dynamic capabilities of the vehicle and also the pneumatic tyres' limitations. The vehicle side-slip angle, as a measure of the vehicle dynamic safety, should be narrowed into an acceptable range. This paper demonstrates that active inverted wings can provide noteworthy dynamic capabilities and enhance the safety features of race cars. Detailed analytical study and formulations of the race car nonlinear model with the airfoils are presented. Computer simulations are carried out to evaluate the performance of the proposed active aerodynamic system.

  12. Optimism about safety and group-serving interpretations of safety among pedestrians and cyclists in relation to road use in general and under low light conditions.

    PubMed

    King, M J; Wood, J M; Lacherez, P F; Marszalek, R P

    2012-01-01

    Drivers are known to be optimistic about their risk of crash involvement, believing that they are less likely to be involved in a crash than other drivers. However, little comparative research has been conducted among other road users. In addition, optimism about crash risk is conceptualised as applying only to an individual's assessment of his or her personal risk of crash involvement. The possibility that the self-serving nature of optimism about safety might be generalised to the group-level as a cyclist or a pedestrian, i.e., becoming group-serving rather than self-serving, has been overlooked in relation to road safety. This study analysed a subset of data collected as part of a larger research project on the visibility of pedestrians, cyclists and road workers, focusing on a set of questionnaire items administered to 406 pedestrians, 838 cyclists and 622 drivers. The items related to safety in various scenarios involving drivers, pedestrians and cyclists, allowing predictions to be derived about group differences in agreement with items based on the assumption that the results would exhibit group-serving bias. Analysis of the responses indicated that specific hypotheses about group-serving interpretations of safety and responsibility were supported in 22 of the 26 comparisons. When the nine comparisons relevant to low lighting conditions were considered separately, seven were found to be supported. The findings of the research have implications for public education and for the likely acceptance of messages which are inconsistent with current assumptions and expectations of pedestrians and cyclists. They also suggest that research into group-serving interpretations of safety, even for temporary roles rather than enduring groups, could be fruitful. Further, there is an implication that gains in safety can be made by better educating road users about the limitations of their visibility and the ramifications of this for their own road safety, particularly in low

  13. Work Practice Simulation of Complex Human-Automation Systems in Safety Critical Situations: The Brahms Generalized berlingen Model

    NASA Technical Reports Server (NTRS)

    Clancey, William J.; Linde, Charlotte; Seah, Chin; Shafto, Michael

    2013-01-01

    The transition from the current air traffic system to the next generation air traffic system will require the introduction of new automated systems, including transferring some functions from air traffic controllers to on­-board automation. This report describes a new design verification and validation (V&V) methodology for assessing aviation safety. The approach involves a detailed computer simulation of work practices that includes people interacting with flight-critical systems. The research is part of an effort to develop new modeling and verification methodologies that can assess the safety of flight-critical systems, system configurations, and operational concepts. The 2002 Ueberlingen mid-air collision was chosen for analysis and modeling because one of the main causes of the accident was one crew's response to a conflict between the instructions of the air traffic controller and the instructions of TCAS, an automated Traffic Alert and Collision Avoidance System on-board warning system. It thus furnishes an example of the problem of authority versus autonomy. It provides a starting point for exploring authority/autonomy conflict in the larger system of organization, tools, and practices in which the participants' moment-by-moment actions take place. We have developed a general air traffic system model (not a specific simulation of Überlingen events), called the Brahms Generalized Ueberlingen Model (Brahms-GUeM). Brahms is a multi-agent simulation system that models people, tools, facilities/vehicles, and geography to simulate the current air transportation system as a collection of distributed, interactive subsystems (e.g., airports, air-traffic control towers and personnel, aircraft, automated flight systems and air-traffic tools, instruments, crew). Brahms-GUeM can be configured in different ways, called scenarios, such that anomalous events that contributed to the Überlingen accident can be modeled as functioning according to requirements or in an

  14. Feasibility, safety, and efficacy of domiciliary thrombolysis by general practitioners: Grampian region early anistreplase trial. GREAT Group.

    PubMed Central

    1992-01-01

    OBJECTIVE--To assess the feasibility, safety, and efficacy of domiciliary thrombolysis by general practitioners. DESIGN--Randomised double blind parallel group trial of anistreplase 30 units intravenously and placebo given either at home or in hospital. SETTING--29 rural practices in Grampian admitting patients to teaching hospitals in Aberdeen (average distance 36 (range 16-62) miles). PATIENTS--311 patients with suspected acute myocardial infarction and no contraindications to thrombolytic therapy seen at home within four hours of onset of symptoms. MAIN OUTCOME MEASURES--Time saving, adverse events, Q wave infarction, left ventricular function. RESULTS--Anistreplase was administered at home 101 minutes after onset of symptoms, while anistreplase was given in hospital 240 minutes after onset of symptoms (median times). Adverse events after thrombolysis were infrequent and, apart from cardiac arrest, not a serious problem when they occurred in the community: seven of 13 patients were resuscitated after cardiac arrest out of hospital. By three months after trial entry the relative reduction of deaths from all causes in patients given thrombolytic therapy at home was 49% (13/163 (8.0%) v 23/148 (15.5%); difference -7.6% (95% confidence interval -14.7% to -0.4%), p = 0.04). Full thickness Q wave infarction was less common in patients with confirmed infarction receiving treatment at home (65/122 (53.3%) v 76/112 (67.9%); difference -14.6% (95% confidence interval -27.0% to -2.2%), p = 0.02). CONCLUSIONS--General practitioners provided rapid pre-hospital coronary care of a high standard. Compared with later administration in hospital, giving anistreplase at home resulted in reduction in mortality, fewer cardiac arrests, fewer Q wave infarcts, and better left ventricular function. Benefits were most marked where thrombolytic therapy was administered within two hours of the onset of symptoms. PMID:1393033

  15. 78 FR 69118 - Information Collection Activities: General; Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-18

    ...; 134E1700D2 EEEE500000 ET1SF0000.DAQ000] Information Collection Activities: General; Proposed Collection... Subpart A, General. The new form is BSEE-0011 and entails no additional information collection burden to..., Subpart A, General. OMB Control Number: 1014-0022. Form(s): BSEE-0011. Abstract: The Outer...

  16. OCCUPATIONAL SAFETY AND HEALTH IN DISASTER RESTORATION ACTIVITY AFTER SOME MAJOR EARTHQUAKES

    NASA Astrophysics Data System (ADS)

    Toyosawa, Yasuo; Itoh, Kazuya; Kikkawa, Naotaka

    Occupational safety and health in disaster restoration activity following the Great Hanshin Earthquake (1995), Niigata Chuetsu Earthquake (2004), Niigata Chuetsu-oki Earthquake (2007) Great East Japan Earthquake (2011) were analyzed and characterized in order to raise awareness on the risks and hazards in such work. In this scenario, the predominant type of accident is a "fall" which increases mainly due to the fact that labourers are working to repair houses and buildings. On the other hand, landslides were prevalent in the Niigata Chuetsu Earthquake, resulting in more accidents occurring during geotechnical works rather than in buildings construction works. In the abnormal conditions that characterize recovery activities, when safety and health measures have a tendency to be neglected, it is important to reinstate adequate measures as soon as possible by carrying out the usial risk assessments.

  17. Sex Differences in Brain Activity Related to General and Emotional Intelligence

    ERIC Educational Resources Information Center

    Jausovec, Norbert; Jausovec, Ksenija

    2005-01-01

    The study investigated gender differences in resting EEG (in three individually determined narrow [alpha] frequency bands) related to the level of general and emotional intelligence. Brain activity of males decreased with the level of general intelligence, whereas an opposite pattern of brain activity was observed in females. This difference was…

  18. 29 CFR 780.216 - Nursery activities generally and Christmas tree production.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Nursery activities generally and Christmas tree production... Nursery activities generally and Christmas tree production. (a) The employees of a nursery who are engaged... fruit, nut, shade, vegetable, and ornamental plants or trees, and shrubs, vines, and flowers;...

  19. 29 CFR 780.216 - Nursery activities generally and Christmas tree production.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Nursery activities generally and Christmas tree production... Nursery activities generally and Christmas tree production. (a) The employees of a nursery who are engaged... fruit, nut, shade, vegetable, and ornamental plants or trees, and shrubs, vines, and flowers;...

  20. 29 CFR 780.216 - Nursery activities generally and Christmas tree production.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Nursery activities generally and Christmas tree production. 780.216 Section 780.216 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION... Nursery activities generally and Christmas tree production. (a) The employees of a nursery who are...

  1. Steel Erection Safety. Module SH-39. Safety and Health.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    This student module on steel erection safety is one of 50 modules concerned with job safety and health. This module identifies typical jobsite hazards encountered by steel erectors, as well as providing safe job procedures for general and specific construction activities. Following the introduction, 11 objectives (each keyed to a page in the text)…

  2. Update to the safety program for the general-purpose heat source radioisotope thermoelectric generators for the Galileo and Ulysses missions

    NASA Technical Reports Server (NTRS)

    Bennett, Gary L.; Bradshaw, C. T.; Englehart, Richard W.; Bartram, Bart W.; Cull, Theresa A.; Zocher, Roy W.; Eck, Marshall B.; Mukunda, Meera; Brenza, Peter T.; Chan, Chris C.

    1992-01-01

    With the rescheduling of the Galileo and Ulysses launches and the use of new upper stages following the Challenger accident, the aerospace nuclear safety program for the general-purpose heat source radioisotope thermoelectric generators (GPHS-RTGs) was extended to accommodate the new mission scenarios. As in the original safety program, the objectives were to determine the response of the GPHS-RTG to the various postulated accident environments and to determine the risk (if any) associated with these postulated accidents. The extended GPHS-RTG safety program was successfully completed in sufficient time to prepare an updated Final Safety Analysis Report (FSAR) with revisions for the October 1989 launch of the Galileo spacecraft.

  3. Guidelines for the use of microcomputer applications in safety- related activities (NCIG-20)

    SciTech Connect

    Domenico, W.F. )

    1992-07-01

    This document presents guidelines and supporting information for the use of microcomputer applications in safety-related activities. The guidelines address controls that should be implemented following development of the applications, in order to ensure that accurate, traceable, and reproducible results are obtained when the applications are used. Guidelines are presented for management, the organization or person supplying the application, and the user of the application.

  4. 78 FR 18617 - Recreational Boating Safety Projects, Programs and Activities Funded Under Provisions of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-27

    ...In 1999, the Transportation Equity Act for the 21st Century made $5 million per year available for the payment of Coast Guard expenses for personnel and activities directly related to coordinating and carrying out the national recreational boating safety program. In 2005, the law was amended, and the amount was increased to $5.5 million. The Coast Guard is publishing this notice to satisfy a......

  5. Validation of a common data model for active safety surveillance research

    PubMed Central

    Ryan, Patrick B; Reich, Christian G; Hartzema, Abraham G; Stang, Paul E

    2011-01-01

    Objective Systematic analysis of observational medical databases for active safety surveillance is hindered by the variation in data models and coding systems. Data analysts often find robust clinical data models difficult to understand and ill suited to support their analytic approaches. Further, some models do not facilitate the computations required for systematic analysis across many interventions and outcomes for large datasets. Translating the data from these idiosyncratic data models to a common data model (CDM) could facilitate both the analysts' understanding and the suitability for large-scale systematic analysis. In addition to facilitating analysis, a suitable CDM has to faithfully represent the source observational database. Before beginning to use the Observational Medical Outcomes Partnership (OMOP) CDM and a related dictionary of standardized terminologies for a study of large-scale systematic active safety surveillance, the authors validated the model's suitability for this use by example. Validation by example To validate the OMOP CDM, the model was instantiated into a relational database, data from 10 different observational healthcare databases were loaded into separate instances, a comprehensive array of analytic methods that operate on the data model was created, and these methods were executed against the databases to measure performance. Conclusion There was acceptable representation of the data from 10 observational databases in the OMOP CDM using the standardized terminologies selected, and a range of analytic methods was developed and executed with sufficient performance to be useful for active safety surveillance. PMID:22037893

  6. Preliminary Results of Ancillary Safety Analyses Supporting TREAT LEU Conversion Activities

    SciTech Connect

    Brunett, A. J.; Fei, T.; Strons, P. S.; Papadias, D. D.; Hoffman, E. A.; Kontogeorgakos, D. C.; Connaway, H. M.; Wright, A. E.

    2015-10-01

    Report (FSAR) [3]. Depending on the availability of historical data derived from HEU TREAT operation, results calculated for the LEU core are compared to measurements obtained from HEU TREAT operation. While all analyses in this report are largely considered complete and have been reviewed for technical content, it is important to note that all topics will be revisited once the LEU design approaches its final stages of maturity. For most safety significant issues, it is expected that the analyses presented here will be bounding, but additional calculations will be performed as necessary to support safety analyses and safety documentation. It should also be noted that these analyses were completed as the LEU design evolved, and therefore utilized different LEU reference designs. Preliminary shielding, neutronic, and thermal hydraulic analyses have been completed and have generally demonstrated that the various LEU core designs will satisfy existing safety limits and standards also satisfied by the existing HEU core. These analyses include the assessment of the dose rate in the hodoscope room, near a loaded fuel transfer cask, above the fuel storage area, and near the HEPA filters. The potential change in the concentration of tramp uranium and change in neutron flux reaching instrumentation has also been assessed. Safety-significant thermal hydraulic items addressed in this report include thermally-induced mechanical distortion of the grid plate, and heating in the radial reflector.

  7. Is the relationship between the built environment and physical activity moderated by perceptions of crime and safety?

    PubMed Central

    2014-01-01

    Background Direct relationships between safety concerns and physical activity have been inconsistently patterned in the literature. To tease out these relationships, crime, pedestrian, and traffic safety were examined as moderators of built environment associations with physical activity. Methods Exploratory analyses used two cross-sectional studies of 2068 adults ages 20–65 and 718 seniors ages 66+ with similar designs and measures. The studies were conducted in the Baltimore, Maryland-Washington, DC and Seattle-King County, Washington regions during 2001–2005 (adults) and 2005–2008 (seniors). Participants were recruited from areas selected to sample high- and low- income and walkability. Independent variables perceived crime, traffic, and pedestrian safety were measured using scales from validated instruments. A GIS-based walkability index was calculated for a street-network buffer around each participant’s home address. Outcomes were total physical activity measured using accelerometers and transportation and leisure walking measured with validated self-reports (IPAQ-long). Mixed effects regression models were conducted separately for each sample. Results Of 36 interactions evaluated across both studies, only 5 were significant (p < .05). Significant interactions did not consistently support a pattern of highest physical activity when safety was rated high and environments were favorable. There was not consistent evidence that safety concerns reduced the beneficial effects of favorable environments on physical activity. Only pedestrian safety showed evidence of a consistent main effect with physical activity outcomes, possibly because pedestrian safety items (e.g., crosswalks, sidewalks) were not as subjective as those on the crime and traffic safety scales. Conclusions Clear relationships between crime, pedestrian, and traffic safety with physical activity levels remain elusive. The development of more precise safety variables and the use of

  8. On School Bus Safety. Report of the Department of Education to the Governor and the General Assembly of Virginia. House Document No. 10.

    ERIC Educational Resources Information Center

    Virginia State General Assembly, Richmond. House.

    An advisory committee, in response to a 1985 resolution by the Virginia General Assembly, presents this analysis and makes recommendations concerning state school bus safety. The report is divided into eight topics; six appendices comprise three-fourths of the study. "Origin of the Study" states requests to be investigated by the department of…

  9. Safety Handbook.

    ERIC Educational Resources Information Center

    Montgomery County Public Schools, Rockville, MD.

    Safety policies, procedures, and related information are presented in this manual to assist school personnel in a continuing program of accident prevention. Chapter 1 discusses safety education and accident prevention in general. Chapter 2 covers traffic regulations relating to school safety patrols, school bus transportation, bicycles, and…

  10. Integration of Active and Passive Safety Technologies--A Method to Study and Estimate Field Capability.

    PubMed

    Hu, Jingwen; Flannagan, Carol A; Bao, Shan; McCoy, Robert W; Siasoco, Kevin M; Barbat, Saeed

    2015-11-01

    The objective of this study is to develop a method that uses a combination of field data analysis, naturalistic driving data analysis, and computational simulations to explore the potential injury reduction capabilities of integrating passive and active safety systems in frontal impact conditions. For the purposes of this study, the active safety system is actually a driver assist (DA) feature that has the potential to reduce delta-V prior to a crash, in frontal or other crash scenarios. A field data analysis was first conducted to estimate the delta-V distribution change based on an assumption of 20% crash avoidance resulting from a pre-crash braking DA feature. Analysis of changes in driver head location during 470 hard braking events in a naturalistic driving study found that drivers' head positions were mostly in the center position before the braking onset, while the percentage of time drivers leaning forward or backward increased significantly after the braking onset. Parametric studies with a total of 4800 MADYMO simulations showed that both delta-V and occupant pre-crash posture had pronounced effects on occupant injury risks and on the optimal restraint designs. By combining the results for the delta-V and head position distribution changes, a weighted average of injury risk reduction of 17% and 48% was predicted by the 50th percentile Anthropomorphic Test Device (ATD) model and human body model, respectively, with the assumption that the restraint system can adapt to the specific delta-V and pre-crash posture. This study demonstrated the potential for further reducing occupant injury risk in frontal crashes by the integration of a passive safety system with a DA feature. Future analyses considering more vehicle models, various crash conditions, and variations of occupant characteristics, such as age, gender, weight, and height, are necessary to further investigate the potential capability of integrating passive and DA or active safety systems. PMID

  11. Efficacy and safety of low-dose ketamine as an adjunct analgesic and amnesic during caesarean section under general anaesthesia

    PubMed Central

    Rajan, Sunil; Hassain, Anwar; Puthenveettil, Nitu; Kumar, Lakshmi

    2015-01-01

    Background and Aims: The practice of avoiding sedatives or anxiolytics during caesarean section under general anaesthesia (GA) until delivery of the baby could result in exaggerated haemodynamic responses and an increased risk of awareness. We aimed to assess the efficacy and safety of low-dose ketamine, used as an adjunct analgesic and amnesic, in attenuating these responses during caesarean section under GA. Methods: This prospective, randomised study was conducted in 40 patients. Group K (n = 20) received 0.25 mg/kg ketamine, whereas Group C received 5 ml normal saline intravenously (IV) just before induction of anaesthesia. After intubation, patients were ventilated with O2 and N2O (40:60%) with 0.7% end-tidal isoflurane. Fentanyl and midazolam were given following delivery of the baby. Mann–Whitney and Fisher's exact tests were used for statistical analysis. Results: Preinduction haemodynamic parameters and those recorded at 1 min after induction were comparable in both groups. However, heart rate and systolic blood pressure recorded after intubation (at 3, 5, 7, 9, 12, 15, 20, 30 and 45 min after induction) showed significantly high values in Group C (P < 0.05). Mean arterial pressure also showed a similar pattern. Umbilical vein pO2, pCO2 and pH were comparable in both groups. Though Apgar score at 1 min showed a higher scoring in Group K, at 5 min both groups had comparable scores. In Group C, intraoperative lacrimation (50% vs. 0%) and hallucinations/recall of intraoperative events (10% vs. 0%) were high. Conclusion: IV ketamine 0.25 mg/kg can be safely used as an adjunct analgesic and amnesic to attenuate haemodynamic responses during caesarean section under GA without affecting the foetal outcome. PMID:26644613

  12. Safe Physical Activity Environments--To What Extent Are Local Government Authorities Auditing the Safety of Grassed Sporting Grounds?

    ERIC Educational Resources Information Center

    Otago, Leonie; Swan, Peter; Donaldson, Alex; Payne, Warren; Finch, Caroline

    2009-01-01

    Physical activity (PA) participation is influenced by the safety of the settings in which it is undertaken. This study describes the grounds assessment practices of Local Government Authorities (LGAs) in Victoria, Australia to ensure the safety of grassed sporting grounds. It also makes recommendations for improving these practices to maximise the…

  13. Development and Validation of Career Development Guidelines by Task/Activity Analysis of Occupational Safety and Health Professions: Industrial Hygiene and Safety Professional. Final Report. Technical Report XII.

    ERIC Educational Resources Information Center

    Vernon, Ralph J.; And Others

    This report summarizes research findings which resulted in development of curricula for occupational safety and health professions based on task/activity analyses and related performance objectives. The first seven chapters focus on the seven objectives. Chapter 1, Literature Review and Selection of Employers, concerns tasks required for…

  14. Safety Panel Resources

    NASA Technical Reports Server (NTRS)

    Stewart, Christine E.

    2008-01-01

    The goal of this paper is to explore what resources are potentially available to safety panels and to provide some guidance on how to utilize those resources. While the examples used in this paper will concentrate on the Flight Equipment and Reliability Review Panel (FESRRP) and Extravehicular Activity (EVA) hardware that have come through that panel, as well as resources at Johnson Space Center, the paper will address how this applies to safety panels in general, and where possible cite examples for other safety panels.

  15. Making Sense of Safety: Cooperative Learning Activities Allow Students Time to Reflect on the Implications of Lab Safety Rules

    ERIC Educational Resources Information Center

    Barrier, Regina

    2005-01-01

    An important part of the science classroom involves teaching students how to safely use tools, techniques, and procedures. As emphasized in the National Science Education Standards, "safety is a fundamental concern in all experiential science" and teachers must "teach students how to engage safely in investigations inside and outside the…

  16. 24 CFR 574.310 - General standards for eligible housing activities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Uses of Grant Funds § 574.310 General standards for eligible housing activities. All grantees using grant funds to provide housing must adhere to the following standards: (a)(1) General. The grantee shall... care expenses and are described in detail in 24 CFR 5.609). The calculation of the family's...

  17. 24 CFR 574.310 - General standards for eligible housing activities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Uses of Grant Funds § 574.310 General standards for eligible housing activities. All grantees using grant funds to provide housing must adhere to the following standards: (a)(1) General. The grantee shall... care expenses and are described in detail in 24 CFR 5.609). The calculation of the family's...

  18. 24 CFR 574.310 - General standards for eligible housing activities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Uses of Grant Funds § 574.310 General standards for eligible housing activities. All grantees using grant funds to provide housing must adhere to the following standards: (a)(1) General. The grantee shall... care expenses and are described in detail in 24 CFR 5.609). The calculation of the family's...

  19. 24 CFR 574.310 - General standards for eligible housing activities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Uses of Grant Funds § 574.310 General standards for eligible housing activities. All grantees using grant funds to provide housing must adhere to the following standards: (a)(1) General. The grantee shall... care expenses and are described in detail in 24 CFR 5.609). The calculation of the family's...

  20. Efficacy and Safety of Bevacizumab in Active Brain Metastases from Non-Small Cell Lung Cancer

    PubMed Central

    De Braganca, Kevin C.; Janjigian, Yelena Y.; Azzoli, Christopher G.; Kris, Mark G.; Pietanza, Maria C.; Nolan, Craig P.; Omuro, Antonio M.; Holodny, Andrei I.; Lassman, Andrew B.

    2011-01-01

    Background Bevacizumab is effective for the treatment of non-small cell lung cancer (NSCLC). Ongoing trials are exploring the safety of bevacizumab in patients with inactive, previously treated brain metastases. However, bevacizumab safety and efficacy in the treatment of active brain metastases is unknown. Bevacizumab received accelerated FDA approval for progressive glioblastoma, a primary brain tumor, because of high response rates and low incidence of intracranial hemorrhage. Methods We retrospectively identified patients treated with bevacizumab for active (treatment naïve or progressive) central nervous system (CNS) metastases from NSCLC. MRI scans performed at least 6 weeks after initiating bevacizumab were assessed for response. Results There were six patients, four women and two men with a median age of 60 years (range 59–77) at initiation of bevacizumab. Five patients had progressive CNS metastases despite prior treatment including surgery, radiotherapy, and/or chemotherapy; one patient had treatment-naïve brain metastases. Two patients had leptomeningeal metastases, isolated or coexistent with parenchymal brain metastases in one patient each. Bevacizumab was administered alone to one patient and in combination with various cytotoxic chemotherapies in the others. Toxicity included an asymptomatic (Grade 1) intra-tumoral hemorrhage which occurred in one of three patients receiving concurrent anticoagulation with bevacizumab. There was no recurrent CNS bleeding in two patients with a prior history of such hemorrhage. Best response (RECIST) was partial in two, stable disease in three, and progression in one. Median progression-free survival (PFS) was 4.7 months and median overall survival (OS) was 14.1 months following initiation of bevacizumab. Clinical benefit was also observed in the form of improved symptoms and reduced corticosteroid requirements. Conclusions Bevacizumab should be used with caution in patients with active CNS metastases pending

  1. The Positive Effect on Determinants of Physical Activity of a Tailored, General Practice-Based Physical Activity Intervention

    ERIC Educational Resources Information Center

    Van Sluijs, E. M. F.; Van Poppel, M. N. M.; Twisk, J. W. R.; Brug, J.; Van Mechelen, W.

    2005-01-01

    PACE (Physician-based Assessment and Counseling for Exercise) is an individualized theory-based minimal intervention strategy aimed at the enhancement of regular physical activity. The aim of this study was to evaluate the effectiveness of a PACE intervention applied by general practitioners (GPs) on potential determinants of physical activity. A…

  2. Status of Safety and Environmental Activities in the US Fusion Program

    SciTech Connect

    David A. Petti; Susana Reyes; Lee C. Cadwallader; Jeffery F. Latkowski

    2004-09-01

    This paper presents an overview of recent safety efforts in both magnetic and inertial fusion energy. Safety has been a part of fusion design and operations since the inception of fusion research. Safety research and safety design support have been provided for a variety of experiments in both the magnetic and inertial fusion programs. The main safety issues are reviewed, some recent safety highlights are discussed and the programmatic impacts that safety research has had are presented. Future directions in the safety and environmental area are proposed.

  3. Status of Safety and Environmental Activities in the US Fusion Program

    SciTech Connect

    Petti, D A; Reyes, S; Cadwallader, L C; Latkowski, J F

    2004-09-02

    This paper presents an overview of recent safety efforts in both magnetic and inertial fusion energy. Safety has been a part of fusion design and operations since the inception of fusion research. Safety research and safety design support have been provided for a variety of experiments in both the magnetic and inertial fusion programs. The main safety issues are reviewed, some recent safety highlights are discussed and the programmatic impacts that safety research has had are presented. Future directions in the safety and environmental area are proposed.

  4. Alcohol and Alcohol Safety. Volume II of II. A Curriculum Manual for Elementary Level. A Teacher's Activities Guide.

    ERIC Educational Resources Information Center

    Finn, Peter; Platt, Judith

    This curriculum manual for the elementary school level is the first in a series on alcohol and alcohol safety and is designed as a teacher's activities guide. Each activity provided is a self-contained learning experience which requires varying numbers of class period and focuses on one or more objectives. Activities are numbered consecutively and…

  5. Safety-Related Improvisation in Led Outdoor Activities: An Exploratory Investigation into Its Occurrence and Influencing Factors

    ERIC Educational Resources Information Center

    Trotter, Margaret J.; Salmon, Paul M.; Lenné, Michael G.

    2014-01-01

    The dynamic nature of led outdoor activities means that, despite activity providers' best efforts, activity leaders can be exposed to unanticipated situations for which no procedures exist. Improvisation, the spontaneous, real-time conception and execution of a novel response, has been identified as a potential means of maintaining safety in…

  6. Active and Passive Fatigue in Simulated Driving: Discriminating Styles of Workload Regulation and Their Safety Impacts

    PubMed Central

    Saxby, Dyani J.; Matthews, Gerald; Warm, Joel S.; Hitchcock, Edward M.; Neubauer, Catherine

    2015-01-01

    Despite the known dangers of driver fatigue, it is a difficult construct to study empirically. Different forms of task-induced fatigue may differ in their effects on driver performance and safety. Desmond and Hancock (2001) defined active and passive fatigue states that reflect different styles of workload regulation. In 2 driving simulator studies we investigated the multidimensional subjective states and safety outcomes associated with active and passive fatigue. Wind gusts were used to induce active fatigue, and full vehicle automation to induce passive fatigue. Drive duration was independently manipulated to track the development of fatigue states over time. Participants were undergraduate students. Study 1 (N = 108) focused on subjective response and associated cognitive stress processes, while Study 2 (N = 168) tested fatigue effects on vehicle control and alertness. In both studies the 2 fatigue manipulations produced different patterns of subjective response reflecting different styles of workload regulation, appraisal, and coping. Active fatigue was associated with distress, overload, and heightened coping efforts, whereas passive fatigue corresponded to large-magnitude declines in task engagement, cognitive underload, and reduced challenge appraisal. Study 2 showed that only passive fatigue reduced alertness, operationalized as speed of braking and steering responses to an emergency event. Passive fatigue also increased crash probability, but did not affect a measure of vehicle control. Findings support theories that see fatigue as an outcome of strategies for managing workload. The distinction between active and passive fatigue is important for assessment of fatigue and for evaluating automated driving systems which may induce dangerous levels of passive fatigue. PMID:24041288

  7. Nuclear criticality safety guide

    SciTech Connect

    Pruvost, N.L.; Paxton, H.C.

    1996-09-01

    This technical reference document cites information related to nuclear criticality safety principles, experience, and practice. The document also provides general guidance for criticality safety personnel and regulators.

  8. 29 CFR 784.120 - Application of exemption to “offshore” activities in general.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...(a)(5) Exemption § 784.120 Application of exemption to “offshore” activities in general. The expression “offshore activities” is used to describe the category of named operations pertaining to the... 13(a)(5) exempted not only employees employed in such “offshore” or “trip” activities but...

  9. A Minds-On Approach to Active Learning in General Music

    ERIC Educational Resources Information Center

    Scott, Sheila

    2010-01-01

    Minds-on engagement in active learning is explored through the experiences of Margaret Sanders, a general music teacher. Minds-on learners think about their experiences. They are actively involved as questioners and problem solvers while they complete musical tasks and reflect on their work after it is completed. Minds-off learners focus on their…

  10. Activity of the anterior cingulate cortex and ventral hippocampus underlie increases in contextual fear generalization.

    PubMed

    Cullen, Patrick K; Gilman, T Lee; Winiecki, Patrick; Riccio, David C; Jasnow, Aaron M

    2015-10-01

    Memories for context become less specific with time resulting in animals generalizing fear from training contexts to novel contexts. Though much attention has been given to the neural structures that underlie the long-term consolidation of a context fear memory, very little is known about the mechanisms responsible for the increase in fear generalization that occurs as the memory ages. Here, we examine the neural pattern of activation underlying the expression of a generalized context fear memory in male C57BL/6J mice. Animals were context fear conditioned and tested for fear in either the training context or a novel context at recent and remote time points. Animals were sacrificed and fluorescent in situ hybridization was performed to assay neural activation. Our results demonstrate activity of the prelimbic, infralimbic, and anterior cingulate (ACC) cortices as well as the ventral hippocampus (vHPC) underlie expression of a generalized fear memory. To verify the involvement of the ACC and vHPC in the expression of a generalized fear memory, animals were context fear conditioned and infused with 4% lidocaine into the ACC, dHPC, or vHPC prior to retrieval to temporarily inactivate these structures. The results demonstrate that activity of the ACC and vHPC is required for the expression of a generalized fear memory, as inactivation of these regions returned the memory to a contextually precise form. Current theories of time-dependent generalization of contextual memories do not predict involvement of the vHPC. Our data suggest a novel role of this region in generalized memory, which should be incorporated into current theories of time-dependent memory generalization. We also show that the dorsal hippocampus plays a prolonged role in contextually precise memories. Our findings suggest a possible interaction between the ACC and vHPC controls the expression of fear generalization. PMID:26165137

  11. Evaluating life-safety risk of fieldwork at New Zealand's active volcanoes

    NASA Astrophysics Data System (ADS)

    Deligne, Natalia; Jolly, Gill; Taig, Tony; Webb, Terry

    2014-05-01

    Volcano observatories monitor active or potentially active volcanoes. Although the number and scope of remote monitoring instruments and methods continues to grow, in-person field data collection is still required for comprehensive monitoring. Fieldwork anywhere, and especially in mountainous areas, contains an element of risk. However, on volcanoes with signs of unrest, there is an additional risk of volcanic activity escalating while on site, with potentially lethal consequences. As an employer, a volcano observatory is morally and sometimes legally obligated to take reasonable measures to ensure staff safety and to minimise occupational risk. Here we present how GNS Science evaluates life-safety risk for volcanologists engaged in fieldwork on New Zealand volcanoes with signs of volcanic unrest. Our method includes several key elements: (1) an expert elicitation for how likely an eruption is within a given time frame, (2) quantification of, based on historical data when possible, given a small, moderate, or large eruption, the likelihood of exposure to near-vent processes, ballistics, or surge at various distances from the vent, and (3) estimate of fatality rate given exposure to these volcanic hazards. The final product quantifies hourly fatality risk at various distances from a volcanic vent; various thresholds of risk (for example, zones with more than 10-5 hourly fatality risk) trigger different levels of required approval to undertake work. Although an element of risk will always be present when conducting fieldwork on potentially active volcanoes, this is a first step towards providing objective guidance for go/no go decisions for volcanic monitoring.

  12. Medication safety in acute care in Australia: where are we now? Part 2: a review of strategies and activities for improving medication safety 2002-2008

    PubMed Central

    Semple, Susan J; Roughead, Elizabeth E

    2009-01-01

    Background This paper presents Part 2 of a literature review examining medication safety in the Australian acute care setting. This review was undertaken for the Australian Commission on Safety and Quality in Health Care, updating the 2002 national report on medication safety. Part 2 of the review examined the Australian evidence base for approaches to build safer medication systems in acute care. Methods A literature search was conducted to identify Australian studies and programs published from 2002 to 2008 which examined strategies and activities for improving medication safety in acute care. Results and conclusion Since 2002 there has been significant progress in strategies to improve prescription writing in hospitals with the introduction of a National Inpatient Medication Chart. There are also systems in place to ensure a nationally coordinated approach to the ongoing optimisation of the chart. Progress has been made with Australian research examining the implementation of computerised prescribing systems with clinical decision support. These studies have highlighted barriers and facilitators to the introduction of such systems that can inform wider implementation. However, Australian studies assessing outcomes of this strategy on medication incidents or patient outcomes are still lacking. In studies assessing education for reducing medication errors, academic detailing has been demonstrated to reduce errors in prescriptions for Schedule 8 medicines and a program was shown to be effective in reducing error prone prescribing abbreviations. Published studies continue to support the role of clinical pharmacist services in improving medication safety. Studies on strategies to improve communication between different care settings, such as liaison pharmacist services, have focussed on implementation issues now that funding is available for community-based services. Double checking versus single-checking by nurses and patient self-administration in hospital has been

  13. Measuring hospital-wide activity volume for patient safety and infection control: a multi-centre study in Japan

    PubMed Central

    Hayashida, Kenshi; Imanaka, Yuichi; Fukuda, Haruhisa

    2007-01-01

    Background In Japan, as in many other countries, several quality and safety assurance measures have been implemented since the 1990's. This has occurred in spite of cost containment efforts. Although government and hospital decision-makers demand comprehensive analysis of these activities at the hospital-wide level, there have been few studies that actually quantify them. Therefore, the aims of this study were to measure hospital-wide activities for patient safety and infection control through a systematic framework, and to identify the incremental volume of these activities implemented over the last five years. Methods Using the conceptual framework of incremental activity corresponding to incremental cost, we defined the scope of patient safety and infection control activities. We then drafted a questionnaire to analyze these realms. After implementing the questionnaire, we conducted several in-person interviews with managers and other staff in charge of patient safety and infection control in seven acute care teaching hospitals in Japan. Results At most hospitals, nurses and clerical employees acted as the main figures in patient safety practices. The annual amount of activity ranged from 14,557 to 72,996 person-hours (per 100 beds: 6,240; per 100 staff: 3,323) across participant hospitals. Pharmacists performed more incremental activities than their proportional share. With respect to infection control activities, the annual volume ranged from 3,015 to 12,196 person-hours (per 100 beds: 1,141; per 100 staff: 613). For infection control, medical doctors and nurses tended to perform somewhat more of the duties relative to their share. Conclusion We developed a systematic framework to quantify hospital-wide activities for patient safety and infection control. We also assessed the incremental volume of these activities in Japanese hospitals under the reimbursement containment policy. Government and hospital decision makers can benefit from this type of analytic

  14. Can we predict SPEs before solar surface events? For the safety operation of manned space activities-

    NASA Astrophysics Data System (ADS)

    Tomita, F.

    It is foregone conclusion that human activities in space will become more varied and more frequent as we move through the 21st century. Space tourism is now becoming practical realities, and manned Moon base or manned mission to Mars is also now considered feasible. For the safety operations of these manned space activities, the prediction of the Solar energetic Particle Events (SPEs) around the manned missions is one of the most important requisite. A typical SPE will start at 1 AU after a few tens of minutes when we identify the monstrous event near the solar surface by the observations of the peak flux and structure of the X-ray event, and/or brightness and structure of the coronal mass ejection (CME) / flare, and/or special spectral type of solar radio bursts. Consequently, it takes a few hours to reach maximum level. This maximum SPE level is sometimes lethal for the aurora watching space tourists, out-door activities at the Moon base, and extra vehicular activities during Mars explorations. The lead-time of about 2.5 hour or less for lethal SPEs may not be safe enough for future manned space activities. For our children and ground-children, we have to discover most reliable precursors of CME / flare, or think out the most practical prediction tools that are faster than the speed of light.

  15. General aviation activity and avionics survey. Annual summary report, CY 1985

    SciTech Connect

    Not Available

    1987-03-01

    This report presents the results and a description of the 1985 General Aviation Activity and Avionics Survey. The survey was conducted during 1986 by the FAA to obtain information on the activity and avionics of the United States registered general aviation aircraft fleet, the dominant component of civil aviation in the U.S. The survey was based on a statistically selected sample of about 10.3 percent of the general aviation fleet. A responses rate of 63.7 percent was obtained. Survey results based upon response but are expanded upward to represent the total population. Survey results revealed that during 1985 an estimated 34.1 million hours of flying time were logged and 88.7 million operations were performed by the 210,654 active general aviation aircraft in the U.S. fleet. The mean annual flight time per aircraft was 158.2 hours. The active aircraft represented about 77.9 percent of the registered general aviation fleet. The report contains breakdowns of these and other statistics by manufacturer/model group, aircraft, state and region of based aircraft, and primary use. Also included are fuel consumption, lifetime airframe hours, avionics, engine hours, and miles flown estimates, as well as tables for detailed analysis of the avionics capabilities of the general aviation fleet. New to the report this year are estimates of the number of landings, IFR hours flown, and the cost and grade of fuel consumed by the GA fleet.

  16. Direct stroke unit admission of intravenous tissue plasminogen activator: safety, clinical outcome, and hospital cost savings

    PubMed Central

    Alexandrov, Anne W.; Coleman, Kisha C.; Palazzo, Paola; Shahripour, Reza Bavarsad; Alexandrov, Andrei V.

    2016-01-01

    Background: In the USA, stable intravenous tissue plasminogen activator (IV tPA) patients have traditionally been cared for in an intensive care unit (ICU). We examined the safety of using an acuity-adaptable stroke unit (SU) to manage IV tPA patients. Methods: We conducted an observational study of consecutive patients admitted to our acuity-adaptable SU over the first 3 years of operation. Safety was assessed by symptomatic intracerebral hemorrhage (sICH) rates, systemic hemorrhage (SH) rates, tPA-related deaths, and transfers from SU to ICU; cost savings and length of stay (LOS) were determined. Results: We admitted 333 IV tPA patients, of which 302 were admitted directly to the SU. A total of 31 (10%) patients had concurrent systemic hemodynamic or pulmonary compromise warranting direct ICU admission. There were no differences in admission National Institutes of Health Stroke Scale scores between SU and ICU patients (9.0 versus 9.5, respectively). Overall sICH rate was 3.3% (n = 10) and SH rate was 2.9 (n = 9), with no difference between SU and ICU patients. No tPA-related deaths occurred, and no SU patients required transfer to the ICU. Estimated hospital cost savings were US$362,400 for ‘avoided’ ICU days, and hospital LOS decreased significantly (p = 0.001) from 9.8 ± 15.6 days (median 5) in year 1, to 5.2 ± 4.8 days (median 3) by year 3. Conclusions: IV tPA patients may be safely cared for in a SU when nurses undergo extensive education to ensure clinical competence. Use of the ICU solely for monitoring may constitute significant overuse of system resources at an expense that is not associated with additional safety benefit. PMID:27366237

  17. Pharmacokinetics, safety and tolerability of triflusal and its main active metabolite HTB in healthy Chinese subjects.

    PubMed

    Wang, M; Zhang, Q; Huang, M; Zong, S; Hua, W; Zhou, W

    2014-05-01

    Triflusal presents comparable antiplatelet activity to aspirin while presenting a more favourable safety profile, and is used in the treatment of thrombosis. The study aimed to evaluate the pharmacokinetics and safety of triflusal and its major metabolite 2-(hydroxyl)-4-(trifluoromethyl)- benzoic acid (HTB) in healthy Chinese subjects.30 healthy subjects were recruited in this randomized, single-center, and open-label, parallel, single ascending doses (300, 600, 900 mg) and multiple doses (600 mg, once daily for 7 days) study. Plasma samples were analyzed with a validated liquid chromatography tandem mass spectrometry (LC/MS/MS) method. Safety was assessed by adverse events, ECG, laboratory testing, and vital signs.Triflusal was safe and well tolerated. After single-dose administration, triflusal was rapidly absorbed with a mean Tmax of 0.55-0.92 h and a mean t1/2 kel of 0.35-0.65 h, HTB was absorbed with a mean Tmax of 2.35-3.03 h and a mean t1/2 kel of 52.5-65.57 h. Cmax and AUC for triflusal and HTB were approximately dose proportional over the 300-900 mg dose range. In the steady state, the accumulation index (R) indicated that the exposure of triflusal increased slightly with repeated dosing, and the exposure of HTB increased obviously. 3 adverse events certainly related to the investigational drugs occurred in the multiple-dose phase.Following oral dosing under fasting condition, triflusal is promptly absorbed and rapidly depleted from the systemic circulation. HTB is quickly generated from triflusal and slowly eliminated. Triflusal accumulates slightly in the body. HTB plasma concentration builds up progressively toward steady-state. PMID:24105106

  18. Effect of dexamethasone on bacteriostatic activity of turkey monocytes and implications for food safety.

    PubMed

    Huff, G R; Huff, W E; Rath, N C

    2015-08-15

    Stress has been shown to affect the immune system of turkeys making them more susceptible to bacterial infections. Five-week-old male and female turkeys were treated with 3 intra-muscular injections of dexamethasone (Dex) at 0, 0.5 and 2.0mg/kg body weight. Twenty-four hours after the third injection birds were bled and white blood cell (WBC) differentials and bacteriostatic activity of monocytes were measured. Dex at both 0.5 and 2.0mg/kg decreased phagocytic activity in females only. Bacteriostatic activity was decreased at both concentrations of Dex at 8 and 16 h post-infection in both sexes and was lower in males as compared to females. Total WBC counts were increased in females at both concentrations of Dex whereas male total WBC counts were unaffected. Both males and females had an increase in the heterophil to lymphocyte ratio. Within the same study, replicate pens of turkeys were challenged with intra-air sac inoculation of 100 cfu of Escherichia coli. Isolation of E. coli was significantly increased by both Dex and E. coli challenge, but there were no differences between sexes. These results suggest that stress can compromise the bacteriostatic activity of turkey monocytes and increase bacterial colonization of blood and tissues, potentially affecting food safety. PMID:26099808

  19. DOE standard: Integration of environment, safety, and health into facility disposition activities. Volume 2: Appendices

    SciTech Connect

    1998-05-01

    This volume contains the appendices that provide additional environment, safety, and health (ES and H) information to complement Volume 1 of this Standard. Appendix A provides a set of candidate DOE ES and H directives and external regulations, organized by hazard types that may be used to identify potentially applicable directives to a specific facility disposition activity. Appendix B offers examples and lessons learned that illustrate implementation of ES and H approaches discussed in Section 3 of Volume 1. Appendix C contains ISMS performance expectations to guide a project team in developing and implementing an effective ISMS and in developing specific performance criteria for use in facility disposition. Appendix D provides guidance for identifying potential Applicable or Relevant and Appropriate Requirements (ARARs) when decommissioning facilities fall under the Comprehensive Environmental Response, Compensation, Liability Act (CERCLA) process. Appendix E discusses ES and H considerations for dispositioning facilities by privatization. Appendix F is an overview of the WSS process. Appendix G provides a copy of two DOE Office of Nuclear Safety Policy and Standards memoranda that form the bases for some of the guidance discussed within the Standard. Appendix H gives information on available hazard analysis techniques and references. Appendix I provides a supplemental discussion to Sections 3.3.4, Hazard Baseline Documentation, and 3.3.6, Environmental Permits. Appendix J presents a sample readiness evaluation checklist.

  20. Development of U.S. Government General Technical Requirements for UAS Flight Safety Systems Utilizing the Iridium Satellite Constellation

    NASA Technical Reports Server (NTRS)

    Murray, Jennifer; Birr, Richard

    2010-01-01

    This slide presentation reviews the development of technical requirements for Unmanned Aircraft Systems (UAS) utilization of the Iridium Satellite Constellation to provide flight safety. The Federal Aviation Authority (FAA) required an over-the-horizon communication standard to guarantee flight safety before permitting widespread UAS flights in the National Air Space (NAS). This is important to ensure reliable control of UASs during loss-link and over-the-horizon scenarios. The core requirement was to utilize a satellite system to send GPS tracking data and other telemetry from a flight vehicle down to the ground. Iridium was chosen as the system because it is one of the only true satellite systems that has world wide coverage, and the service has a highly reliable link margin. The Iridium system, the flight modems, and the test flight are described.

  1. General aviation activity and avionics survey. 1978. Annual summary report cy 1978

    SciTech Connect

    Schwenk, J.C.

    1980-03-01

    This report presents the results and a description of the 1978 General Aviation Activity and Avionics Survey. The survey was conducted during early 1979 by the FAA to obtain information on the activity and avionics of the United States registered general aviation aircraft fleet, the dominant component of civil aviation in the U.S. The survey was based on a statistically selected sample of about 13.3 percent of the general aviation fleet and obtained a response rate of 74 percent. Survey results are based upon responses but are expanded upward to represent the total population. Survey results revealed that during 1978 an estimated 39.4 million hours of flying time were logged by the 198,778 active general aviation aircraft in the U.S. fleet, yielding a mean annual flight time per aircraft of 197.7 hours. The active aircraft represented 85 percent of the registered general aviation fleet. The report contains breakdowns of these and other statistics by manufacturer/model group, aircraft type, state and region of based aircraft, and primary use. Also included are fuel consumption, lifetime airframe hours, avionics, and engine hours estimates.

  2. General aviation activity and avionics survey. Annual report for CY81

    SciTech Connect

    Schwenk, J.C.; Carter, P.W.

    1982-12-01

    This report presents the results and a description of the 1981 General Aviation Activity and Avionics Survey. The survey was conducted during 1982 by the FAA to obtain information on the activity and avionics of the United States registered general aviation aircraft fleet, the dominant component of civil aviation in the U.S. The survey was based on a statistically selected sample of about 8.9 percent of the general aviation fleet and obtained a response rate of 61 percent. Survey results are based upon response but are expanded upward to represent the total population. Survey results revealed that during 1981 an estimated 40.7 million hours of flying time were logged by the 213,226 active general aviation aircraft in the U.S. fleet, yielding a mean annual flight time per aircraft of 188.1 hours. The active aircraft represented about 83 percent of the registered general aviation fleet. The report contains breakdowns of these and other statistics by manufacturer/model group, aircraft type, state and region of based aircraft, and primary use. Also included are fuel consumption, lifetime airframe hours, avionics, and engine hours estimates. In addition, tables are included for detailed analysis of the avionics capabilities of GA fleet.

  3. Functional Specificity of the Visual Word Form Area: General Activation for Words and Symbols but Specific Network Activation for Words

    ERIC Educational Resources Information Center

    Reinke, Karen; Fernandes, Myra; Schwindt, Graeme; O'Craven, Kathleen; Grady, Cheryl L.

    2008-01-01

    The functional specificity of the brain region known as the Visual Word Form Area (VWFA) was examined using fMRI. We explored whether this area serves a general role in processing symbolic stimuli, rather than being selective for the processing of words. Brain activity was measured during a visual 1-back task to English words, meaningful symbols…

  4. Novel activity-dependent approaches to therapeutic hypnosis and psychotherapy: the general waking trance.

    PubMed

    Rossi, Ernest; Erickson-Klein, Roxanna; Rossi, Kathryn

    2008-10-01

    This paper presents a highly edited version of a videotape made in 1980 by Marion Moore, M.D., showing Milton H. Erickson and Moore demonstrating novel, activity-dependent approaches to hand-levitation and therapeutic hypnosis on their subject, Ernest Rossi. Erickson's naturalistic and utilization approach is described in his very direct and surprising induction in a trance challenged patient. These novel, and surprising inductions are examples of how Erickson was prescient in developing activity-dependent approaches to therapeutic hypnosis and psychotherapy several generations before modern neuroscience documented the activity-dependent molecular-genomic mechanisms of memory, learning, and behavior change. Erickson describes a case where he utilized what he called, "The General Waking Trance" when he "dared" not use an obvious hypnotic induction. It is proposed that the states of intense mental absorption and response attentiveness that are facilitated by the general waking trance are functionally related to the three conditions neuroscientists have identified as novelty, enrichment, and exercise (both mental and physical), which can turn on activity-dependent gene expression and activity-dependent brain plasticity, that are the molecular-genomic and neural basis ofmemory, learning, consciousness, and behavior change. We recommend that the next step in investigating the efficacy of therapeutic hypnosis will be in partnering with neuroscientists to explore the possibilities and limitations of utilizing the activity-dependent approaches to hypnotic induction and the general waking trance in facilitating activity-dependent gene expression and brain plasticity. PMID:18998388

  5. Current environmental, health, safety, and socioeconomic research activities related to oil shale: draft

    SciTech Connect

    Not Available

    1980-09-01

    This document was prepared for DOE Resource Applications. It provides a compilation of information on current environmental, health, safety and socioeconomic research activities related to oil shale. The information is the most recent available through August 29, 1980. Included are the following: (1) project title; (2) adminstering agency; (3) contractor; (4) project status; (5) funding level; (6) project schedule; (7) deliverable; and (8) key personnel. The data contained in these reports can be used in environmental impact analyses relating oil shale to various incentives given in the Alternative Fuels Bill. The information provided was obtained from computer search printouts, review of respective agency documents and communication with agency personnel. A complete list of references is provided. The sponsoring organizations include the Department of Energy, the Environmental Protection Agency, the Department of Agriculture, and the Department of Interior.

  6. Standardization in fiber-optic sensing for structural safety: activities in the ISHMII and IEC

    NASA Astrophysics Data System (ADS)

    Habel, Wolfgang R.; Krebber, K.; Daum, W.

    2015-03-01

    Fiber-optic sensors are increasingly established in the sensor market. Their advantages have unquestionably been verified by numerous demonstrations to enhance the operational performance of aged structures or to monitor the structural behavior of safety-relevant structures or their components. However, there are some barriers in use due to a lack of extensive standardization of fiber-optic sensors. This leads very often to restraints in the user's community. The paper shows the status in international standardization of fiber-optic sensors as well as current activities in leading institutions such as IEC and ISHMII and others with the purpose of providing relevant standards for a broader use of selected fiber-optic sensor technologies.

  7. EH&S annual report: Summary of activities Environment, Health and Safety Division, 1992

    SciTech Connect

    Not Available

    1994-03-01

    This report presents an overview of the environment, safety, and health program in operation at the Lawrence Berkeley Laboratory. description of research in environmental science, remediation, waste management, safety, health services, radiation assessment, and emergency plans are provided.

  8. The use of a running wheel to measure activity in rodents: relationship to energy balance, general activity, and reward.

    PubMed

    Novak, Colleen M; Burghardt, Paul R; Levine, James A

    2012-03-01

    Running wheels are commonly employed to measure rodent physical activity in a variety of contexts, including studies of energy balance and obesity. There is no consensus on the nature of wheel-running activity or its underlying causes, however. Here, we will begin by systematically reviewing how running wheel availability affects physical activity and other aspects of energy balance in laboratory rodents. While wheel running and physical activity in the absence of a wheel commonly correlate in a general sense, in many specific aspects the two do not correspond. In fact, the presence of running wheels alters several aspects of energy balance, including body weight and composition, food intake, and energy expenditure of activity. We contend that wheel-running activity should be considered a behavior in and of itself, reflecting several underlying behavioral processes in addition to a rodent's general, spontaneous activity. These behavioral processes include defensive behavior, predatory aggression, and depression- and anxiety-like behaviors. As it relates to energy balance, wheel running engages several brain systems-including those related to the stress response, mood, and reward, and those responsive to growth factors-that influence energy balance indirectly. We contend that wheel-running behavior represents factors in addition to rodents' tendency to be physically active, engaging additional neural and physiological mechanisms which can then independently alter energy balance and behavior. Given the impact of wheel-running behavior on numerous overlapping systems that influence behavior and physiology, this review outlines the need for careful design and interpretation of studies that utilize running wheels as a means for exercise or as a measurement of general physical activity. PMID:22230703

  9. Physical activity in adolescents with psychiatric disorders and in the general population

    PubMed Central

    2014-01-01

    Background Adults who suffer from psychiatric disorders report low levels of physical activity and the activity levels differ between disorders. Less is known regarding physical activity across psychiatric disorders in adolescence. We investigate the frequency and type of physical activity in adolescent psychiatric patients, compared with adolescents in the general population. Methods A total of 566 adolescent psychiatric patients aged 13–18 years who participated in the CAP survey, Norway, were compared to 8173 adolescents aged 13–19 years who participated in the Nord-Trøndelag Health Study, Young-HUNT 3, Norway. All adolescents completed a questionnaire, including questions about physical activity and participation in team and individual sports. Results Approximately 50% of adolescents with psychiatric disorders and 25% of the population sample reported low levels of physical activity. Within the clinical sample, those with mood disorders (62%) and autism spectrum disorders (56%) were the most inactive and those with eating disorders (36%) the most active. This pattern was the same in individual and team sports. After multivariable adjustment, adolescents with a psychiatric disorder had a three-fold increased risk of lower levels of physical activity, and a corresponding risk of not participating in team and individual sports compared with adolescents in the general population. Conclusions Levels of physical activity were low in adolescent psychiatric patients compared with the general population, yet activity levels differed considerably between various disorders. The findings underscore the importance of assessing physical activity in adolescents with psychiatric disorders and providing early intervention to promote mental as well as physical health in this early stage of life. PMID:24450542

  10. A General Strategy to Enhance the Potency of Chimeric Transcriptional Activators

    NASA Astrophysics Data System (ADS)

    Natesan, Sridaran; Molinari, Elizabeth; Rivera, Victor M.; Rickles, Richard J.; Gilman, Michael

    1999-11-01

    Efforts to increase the potency of transcriptional activators are generally unsuccessful because poor expression of activators in mammalian cells limits their delivery to target promoters. Here we report that the effectiveness of chimeric activators can be dramatically improved by expressing them as noncovalent tetrameric bundles. Bundled activation domains are much more effective at activating a reporter gene than simple monomeric activators, presumably because, at similar expression levels, up to 4 times as many the activation domains are delivered to the target promoter. These bundled activation domains are also more effective than proteins in which activation domains are tandemly reiterated in the same polypeptide chain, because such proteins are very poorly expressed and therefore not delivered effectively. These observations suggest that there is a threshold number of activation domains that must be bound to a promoter for activation, above which promoter activity is simply a function of the number of activators bound. We show that bundling can be exploited practically to enhance the sensitivity of mammalian two-hybrid assays, enabling detection of weak interactions or those between poorly expressed proteins. Bundling also dramatically improves the performance of a small-molecule-regulated gene expression system when the expression level of regulatory protein is limiting, a situation that may be encountered in gene therapy applications.

  11. 76 FR 67201 - Information Collection Activities: Oil and Gas Production Safety Systems; Submitted for Office of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-31

    ... Production Safety Systems; Submitted for Office of Management and Budget (OMB) Review; Comment Request ACTION... the paperwork requirements in the regulations under Subpart H, ``Oil and Gas Production Safety Systems... H, Oil and Gas Production Safety Systems. Abstract: The Outer Continental Shelf (OCS) Lands Act,...

  12. 75 FR 27734 - Agency Information Collection Activities; Proposed Collection; Comment Request; Safety Standard...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ... considered children's products under the Consumer Product Safety Act (74 FR 45428). The Commission uses the... From the Federal Register Online via the Government Publishing Office CONSUMER PRODUCT SAFETY... for Bicycle Helmets AGENCY: Consumer Product Safety Commission. ACTION: Notice. SUMMARY: The...

  13. Slow Sleep Spindle Activity, Declarative Memory, and General Cognitive Abilities in Children

    PubMed Central

    Hoedlmoser, Kerstin; Heib, Dominik P.J.; Roell, Judith; Peigneux, Philippe; Sadeh, Avi; Gruber, Georg; Schabus, Manuel

    2014-01-01

    Study Objectives: Functional interactions between sleep spindle activity, declarative memory consolidation, and general cognitive abilities in school-aged children. Design: Healthy, prepubertal children (n = 63; mean age 9.56 ± 0.76 y); ambulatory all-night polysomnography (2 nights); investigating the effect of prior learning (word pair association task; experimental night) versus nonlearning (baseline night) on sleep spindle activity; general cognitive abilities assessed using the Wechsler Intelligence Scale for Children-IV (WISC-IV). Measurements and Results: Analysis of spindle activity during nonrapid eye movement sleep (N2 and N3) evidenced predominant peaks in the slow (11-13 Hz) but not in the fast (13-15 Hz) sleep spindle frequency range (baseline and experimental night). Analyses were restricted to slow sleep spindles. Changes in spindle activity from the baseline to the experimental night were not associated with the overnight change in the number of recalled words reflecting declarative memory consolidation. Children with higher sleep spindle activity as measured at frontal, central, parietal, and occipital sites during both baseline and experimental nights exhibited higher general cognitive abilities (WISC-IV) and declarative learning efficiency (i.e., number of recalled words before and after sleep). Conclusions: Slow sleep spindles (11-13 Hz) in children age 8–11 y are associated with inter-individual differences in general cognitive abilities and learning efficiency. Citation: Hoedlmoser K, Heib DPJ, Roell J, Peigneux P, Sadeh A, Gruber G, Schabus M. Slow sleep spindle activity, declarative memory, and general cognitive abilities in children. SLEEP 2014;37(9):1501-1512. PMID:25142558

  14. Using Computational Chemistry Activities to Promote Learning and Retention in a Secondary School General Chemistry Setting

    ERIC Educational Resources Information Center

    Ochterski, Joseph W.

    2014-01-01

    This article describes the results of using state-of-the-art, research-quality software as a learning tool in a general chemistry secondary school classroom setting. I present three activities designed to introduce fundamental chemical concepts regarding molecular shape and atomic orbitals to students with little background in chemistry, such as…

  15. 78 FR 48647 - Foreign-Trade Zone 225-Springfield, Missouri; Authorization of Production Activity; General...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ...), including notice in the Federal Register inviting public comment (78 FR 22512, 4-16-2013). The FTZ Board has... Activity; General Dynamics Ordnance and Tactical Systems Munitions Services (Demilitarization of Munitions... Dynamics Ordnance and Tactical Systems Munitions Services, within Site 3 of FTZ 225, in Carthage,...

  16. Generalization of the Activated Complex Theory of Reaction Rates. II. Classical Mechanical Treatment

    DOE R&D Accomplishments Database

    Marcus, R. A.

    1964-01-01

    In its usual classical form activated complex theory assumes a particular expression for the kinetic energy of the reacting system -- one associated with a rectilinear motion along the reaction coordinate. The derivation of the rate expression given in the present paper is based on the general kinetic energy expression.

  17. Effects of Active Learning on Enhancing Student Critical Thinking in an Undergraduate General Science Course

    ERIC Educational Resources Information Center

    Kim, Kyoungna; Sharma, Priya; Land, Susan M.; Furlong, Kevin P.

    2013-01-01

    To enhance students' critical thinking in an undergraduate general science course, we designed and implemented active learning modules by incorporating group-based learning with authentic tasks, scaffolding, and individual reports. This study examined the levels of critical thinking students exhibited in individual reports and the students'…

  18. Physical Activity Promotion in General Practices of Barcelona: A Case Study

    ERIC Educational Resources Information Center

    Puig Ribera, Anna; McKenna, Jim; Riddoch, Chris

    2006-01-01

    This case study aimed to generate explanations for the lack of integration of physical activity (PA) promotion in general practices of Barcelona, the capital of Catalonia. This explanatory study adopted a qualitative approach, based on three techniques; focus groups (n = 3), semi-structured (n = 25) and short individual interviews (n = 5). These…

  19. 24 CFR 574.310 - General standards for eligible housing activities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false General standards for eligible housing activities. 574.310 Section 574.310 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN...

  20. Office Occupations--General Clerical. Kit No. 12. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Campbell, Creola S.

    An instructor's manual and student activity guide on general clerical work are provided in this set of prevocational education materials which focuses on the vocational area of office occupations. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  1. 77 FR 23322 - Proposed Information Collection (Report of General Information) Activity: Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ...: Submit written comments on the collection of information through Federal Docket Management System (FDMS.... 3501-3521), Federal agencies must obtain approval from the Office of Management and Budget (OMB) for... AFFAIRS Proposed Information Collection (Report of General Information) Activity: Comment Request...

  2. 29 CFR 784.148 - General scope of processing, freezing, and curing activities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false General scope of processing, freezing, and curing activities. 784.148 Section 784.148 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION... PROVISIONS OF THE FAIR LABOR STANDARDS ACT APPLICABLE TO FISHING AND OPERATIONS ON AQUATIC...

  3. Annual report to Congress. Department of Energy activities relating to the Defense Nuclear Facilities Safety Board, calendar year 2000

    SciTech Connect

    2001-03-01

    This Annual Report to the Congress describes the Department of Energy's activities in response to formal recommendations and other interactions with the Defense Nuclear Facilities Safety Board. During 2000, the Department completed its implementation and proposed closure of one Board recommendation and completed all implementation plan milestones associated with two additional Board recommendations. Also in 2000, the Department formally accepted two new Board recommendations and developed implementation plans in response to those recommendations. The Department also made significant progress with a number of broad-based safety initiatives. These include initial implementation of integrated safety management at field sites and within headquarters program offices, issuance of a nuclear safety rule, and continued progress on stabilizing excess nuclear materials to achieve significant risk reduction.

  4. Evaluation of safety and efficacy of zonisamide in adult patients with partial, generalized, and combined seizures: an open labeled, noncomparative, observational Indian study.

    PubMed

    Dash, Amitabh; Ravat, Sangeeta; Srinivasan, Avathvadi Venkatesan; Shetty, Ashutosh; Kumar, Vivek; Achtani, Renu; Mathur, Vivek Narain; Maramattom, Boby Varkey; Bajpai, Veeresh; Manjunath, Nanjappa C; Narayana, Randhi Venkata; Mehta, Suyog

    2016-01-01

    A prospective, multicentric, noncomparative open-label observational study was conducted to evaluate the safety and efficacy zonisamide in Indian adult patients for the treatment of partial, generalized, or combined seizures. A total of 655 adult patients with partial, generalized, or combined seizures from 30 centers across India were recruited after initial screening. Patients received 100 mg zonisamide as initiating dose as monotherapy/adjunctive therapy for 24 weeks, with titration of 100 mg every 2 weeks if required. Adverse events, responder rates, and seizure freedom were observed every 4 weeks. Efficacy and safety were also assessed using Clinicians Global Assessment of Response to Therapy and Patients Global Assessment of Tolerability to Therapy, respectively. Follow-up was conducted for a period of 24 weeks after treatment initiation. A total of 655 patients were enrolled and received the treatment and 563 completed the evaluation phase. A total of 20.92% of patients received zonisamide as monotherapy or alternative monotherapy and 59.85% patients received zonisamide as first adjunctive therapy. Compared with baseline, 41.22% of patients achieved seizure freedom and 78.6% as responder rate at the end of 24 week study. Most commonly reported adverse events were loss of appetite, weight loss, sedation, and dizziness, but discontinuation due to adverse events of drug was seen in 0.92% of patients. This open label real-world study suggests that zonisamide is an effective and well-tolerated antiepileptic drug in Indian adults for treatment of partial, generalized as well as combined seizures type. No new safety signals were observed. PMID:27013882

  5. Evaluation of safety and efficacy of zonisamide in adult patients with partial, generalized, and combined seizures: an open labeled, noncomparative, observational Indian study

    PubMed Central

    Dash, Amitabh; Ravat, Sangeeta; Srinivasan, Avathvadi Venkatesan; Shetty, Ashutosh; Kumar, Vivek; Achtani, Renu; Mathur, Vivek Narain; Maramattom, Boby Varkey; Bajpai, Veeresh; Manjunath, Nanjappa C; Narayana, Randhi Venkata; Mehta, Suyog

    2016-01-01

    A prospective, multicentric, noncomparative open-label observational study was conducted to evaluate the safety and efficacy zonisamide in Indian adult patients for the treatment of partial, generalized, or combined seizures. A total of 655 adult patients with partial, generalized, or combined seizures from 30 centers across India were recruited after initial screening. Patients received 100 mg zonisamide as initiating dose as monotherapy/adjunctive therapy for 24 weeks, with titration of 100 mg every 2 weeks if required. Adverse events, responder rates, and seizure freedom were observed every 4 weeks. Efficacy and safety were also assessed using Clinicians Global Assessment of Response to Therapy and Patients Global Assessment of Tolerability to Therapy, respectively. Follow-up was conducted for a period of 24 weeks after treatment initiation. A total of 655 patients were enrolled and received the treatment and 563 completed the evaluation phase. A total of 20.92% of patients received zonisamide as monotherapy or alternative monotherapy and 59.85% patients received zonisamide as first adjunctive therapy. Compared with baseline, 41.22% of patients achieved seizure freedom and 78.6% as responder rate at the end of 24 week study. Most commonly reported adverse events were loss of appetite, weight loss, sedation, and dizziness, but discontinuation due to adverse events of drug was seen in 0.92% of patients. This open label real-world study suggests that zonisamide is an effective and well-tolerated antiepileptic drug in Indian adults for treatment of partial, generalized as well as combined seizures type. No new safety signals were observed. PMID:27013882

  6. Unreviewed safety question evaluation of 100K East and 100K West in-basin fuel characterization program activities

    SciTech Connect

    Alwardt, L.D.

    1995-01-12

    The purpose of this report is to provide the basis for answers to an Unreviewed Safety Question (USQ) safety evaluation of the 105K East (KE) and 105K West (KW) in-basin activities associated with the fuel characterization program as described in the characterization shipping plan. The significant activities that are common to both 105 KE and 105 KW basins are the movement of canisters from their main basin storage locations (or potentially from the 105 KE Tech View Pit if a dump table is available) to the south loadout pit transfer channel, hydrogen generation testing in the single element fuel container, loading the single element fuel container into the shipping cask, loading of the shipping cask onto a flat-bed trailer, return of the test fuel elements or element pieces from the 327 facility, placement of the fuel elements back into Mark 2 canisters, and placement of the canisters in the main storage basin. Decapping of canisters in the south loadout pit transfer channel and re-encapsulation of canisters are activities specific to the 105 KW basin. The scope of this safety evaluation includes only those characterization fuel shipment activities performed in the 105 KE and 105 KW fuel storage basin structures up to installation of the overpack. The packaging safety evaluation report governs the shipment of the fuel elements. The K Basins Plant Review Committee has determined that the in-basin activities associated with the fuel characterization program fuel shipments are bounded by the current safety envelop and do not constitute an unreviewed safety question. This determination is documented on Attachment 1.

  7. Predicting Child Physical Activity and Screen Time: Parental Support for Physical Activity and General Parenting Styles

    PubMed Central

    Crain, A. Lauren; Senso, Meghan M.; Levy, Rona L.; Sherwood, Nancy E.

    2014-01-01

    Objective: To examine relationships between parenting styles and practices and child moderate-to-vigorous physical activity (MVPA) and screen time. Methods: Participants were children (6.9 ± 1.8 years) with a body mass index in the 70–95th percentile and their parents (421 dyads). Parent-completed questionnaires assessed parental support for child physical activity (PA), parenting styles and child screen time. Children wore accelerometers to assess MVPA. Results: Parenting style did not predict MVPA, but support for PA did (positive association). The association between support and MVPA, moreover, varied as a function of permissive parenting. For parents high in permissiveness, the association was positive (greater support was related to greater MVPA and therefore protective). For parents low in permissiveness, the association was neutral; support did not matter. Authoritarian and permissive parenting styles were both associated with greater screen time. Conclusions: Parenting practices and styles should be considered jointly, offering implications for tailored interventions. PMID:24812256

  8. Safety in Science. Curriculum Support Series.

    ERIC Educational Resources Information Center

    Lulashnyk, Lorne; Boonov, Janet

    Since the major causes of accidents are carelessness and a negative or apathetic attitude towards safety, this guide was developed to facilitate safe, stimulating science laboratory activities by providing both general and specific safety information presented in 12 sections. Subject areas considered in these sections include: 1)…

  9. Take-Home Challenges: Extending Discovery-Based Activities beyond the General Chemistry Classroom

    NASA Astrophysics Data System (ADS)

    Mason, P. K.; Sarquis, A. M.

    1996-04-01

    In an effort to more effectively integrate the experimental nature of chemistry into our students' experiences, we are developing and implementing discovery-based activities into both the laboratory and lecture components of general chemistry. Below we describe and provide an example of a "take-home challenge" intended to supplement the lecture component of the course. These take-home challenges involve the student in chemistry exploration outside of class and extend the context of content and experimentation into a nontraditional laboratory environment. Over 25 take-home challenges have been developed to date. Preliminary evaluation of the impact of the take-home challenges shows that students reporting themselves as receiving a B or C grade in the course find the challenges very useful in helping them gain a conceptual understanding of the phenomena addressed. Students earning an A grade report little or no impact on their learning. Prepared as one-page handouts, each take-home challenge begins with a scene-setting introduction followed by pertinent background information, a list of materials to be collected, and any appropriate safety precautions. The exploration component of the activity integrates leading questions with the procedural instructions to help guide the students through the discovery process and challenge them to stretch their understanding of the chemistry. After completing a take-home challenge activity, students submit written reports containing responses to the questions posed, observations of data collected, and their responses to the challenge. The accompanying sample take-home challenge activity is provided as a novel adaptation of the belch phenomenon that challenges students to experiment in order to explain the factors that account for the observed behavior. Persons interested in field testing the take-home challenges with their classes should contact the authors. Belch Bottle Challenge: What factors are responsible for the behavior of a

  10. Activation Domain-Specific and General Transcription Stimulation by Native Histone Acetyltransferase Complexes

    PubMed Central

    Ikeda, Keiko; Steger, David J.; Eberharter, Anton; Workman, Jerry L.

    1999-01-01

    Recent progress in identifying the catalytic subunits of histone acetyltransferase (HAT) complexes has implicated histone acetylation in the regulation of transcription. Here, we have analyzed the function of two native yeast HAT complexes, SAGA (Spt-Ada-Gcn5 Acetyltransferase) and NuA4 (nucleosome acetyltransferase of H4), in activating transcription from preassembled nucleosomal array templates in vitro. Each complex was tested for the ability to enhance transcription driven by GAL4 derivatives containing either acidic, glutamine-rich, or proline-rich activation domains. On nucleosomal array templates, the SAGA complex selectively stimulates transcription driven by the VP16 acidic activation domain in an acetyl coenzyme A-dependent manner. In contrast, the NuA4 complex facilitates transcription mediated by any of the activation domains tested if allowed to preacetylate the nucleosomal template, indicating a general stimulatory effect of histone H4 acetylation. However, when the extent of acetylation by NuA4 is limited, the complex also preferentially stimulates VP16-driven transcription. SAGA and NuA4 interact directly with the VP16 activation domain but not with a glutamine-rich or proline-rich activation domain. These data suggest that recruitment of the SAGA and NuA4 HAT complexes by the VP16 activation domain contributes to HAT-dependent activation. In addition, extensive H4/H2B acetylation by NuA4 leads to a general activation of transcription, which is independent of activator-NuA4 interactions. PMID:9858608

  11. A Comparison of the Effectiveness of Interactive Laser Disc and Classroom Video Tape for Safety Instruction of General Motors Workers.

    ERIC Educational Resources Information Center

    Bosco, James; Wagner, Jerry

    1988-01-01

    Describes evaluation that assessed the effectiveness of the Interactive Laser Disc System (ILDS) Training Program in comparison with classroom instruction with videotape for training of General Motors workers. Topics discussed include achievement test, attitude scales, opinion surveys, user preference questionnaires, interviews, and variables that…

  12. Environmental, Health and Safety Assessment: ATS 7H Program (Phase 3R) Test Activities at the GE Power Systems Gas Turbine Manufacturing Facility, Greenville, SC

    SciTech Connect

    1998-11-17

    International Technology Corporation (IT) was contracted by General Electric Company (GE) to assist in the preparation of an Environmental, Health and Safety (HI&3) assessment of the implementation of Phase 3R of the Advanced Turbine System (ATS) 7H program at the GE Gas Turbines facility located in Greenville, South Carolina. The assessment was prepared in accordance with GE's contractual agreement with the U.S. Department of Energy (GE/DOE Cooperative Agreement DE-FC21-95MC3 1176) and supports compliance with the requirements of the National Environmental Policy Act of 1970. This report provides a summary of the EH&S review and includes the following: General description of current site operations and EH&S status, Description of proposed ATS 7H-related activities and discussion of the resulting environmental, health, safety and other impacts to the site and surrounding area. Listing of permits and/or licenses required to comply with federal, state and local regulations for proposed 7H-related activities. Assessment of adequacy of current and required permits, licenses, programs and/or plans.

  13. 77 FR 3784 - Recreational Boating Safety Projects, Programs and Activities Funded Under Provisions of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... safety- related research and analysis. ($693,266). Reimbursable Salaries: Funding was provided to carry... of a professional mathematician/statistician to conduct necessary national surveys and studies...

  14. The Generalized Hill Model: A Kinematic Approach Towards Active Muscle Contraction.

    PubMed

    Göktepe, Serdar; Menzel, Andreas; Kuhl, Ellen

    2014-12-01

    Excitation-contraction coupling is the physiological process of converting an electrical stimulus into a mechanical response. In muscle, the electrical stimulus is an action potential and the mechanical response is active contraction. The classical Hill model characterizes muscle contraction though one contractile element, activated by electrical excitation, and two non-linear springs, one in series and one in parallel. This rheology translates into an additive decomposition of the total stress into a passive and an active part. Here we supplement this additive decomposition of the stress by a multiplicative decomposition of the deformation gradient into a passive and an active part. We generalize the one-dimensional Hill model to the three-dimensional setting and constitutively define the passive stress as a function of the total deformation gradient and the active stress as a function of both the total deformation gradient and its active part. We show that this novel approach combines the features of both the classical stress-based Hill model and the recent active-strain models. While the notion of active stress is rather phenomenological in nature, active strain is micro-structurally motivated, physically measurable, and straightforward to calibrate. We demonstrate that our model is capable of simulating excitation-contraction coupling in cardiac muscle with its characteristic features of wall thickening, apical lift, and ventricular torsion. PMID:25221354

  15. The Generalized Hill Model: A Kinematic Approach Towards Active Muscle Contraction

    PubMed Central

    Menzel, Andreas; Kuhl, Ellen

    2014-01-01

    Excitation-contraction coupling is the physiological process of converting an electrical stimulus into a mechanical response. In muscle, the electrical stimulus is an action potential and the mechanical response is active contraction. The classical Hill model characterizes muscle contraction though one contractile element, activated by electrical excitation, and two non-linear springs, one in series and one in parallel. This rheology translates into an additive decomposition of the total stress into a passive and an active part. Here we supplement this additive decomposition of the stress by a multiplicative decomposition of the deformation gradient into a passive and an active part. We generalize the one-dimensional Hill model to the three-dimensional setting and constitutively define the passive stress as a function of the total deformation gradient and the active stress as a function of both the total deformation gradient and its active part. We show that this novel approach combines the features of both the classical stress-based Hill model and the recent active-strain models. While the notion of active stress is rather phenomenological in nature, active strain is micro-structurally motivated, physically measurable, and straightforward to calibrate. We demonstrate that our model is capable of simulating excitation-contraction coupling in cardiac muscle with its characteristic features of wall thickening, apical lift, and ventricular torsion. PMID:25221354

  16. The generalized Hill model: A kinematic approach towards active muscle contraction

    NASA Astrophysics Data System (ADS)

    Göktepe, Serdar; Menzel, Andreas; Kuhl, Ellen

    2014-12-01

    Excitation-contraction coupling is the physiological process of converting an electrical stimulus into a mechanical response. In muscle, the electrical stimulus is an action potential and the mechanical response is active contraction. The classical Hill model characterizes muscle contraction though one contractile element, activated by electrical excitation, and two non-linear springs, one in series and one in parallel. This rheology translates into an additive decomposition of the total stress into a passive and an active part. Here we supplement this additive decomposition of the stress by a multiplicative decomposition of the deformation gradient into a passive and an active part. We generalize the one-dimensional Hill model to the three-dimensional setting and constitutively define the passive stress as a function of the total deformation gradient and the active stress as a function of both the total deformation gradient and its active part. We show that this novel approach combines the features of both the classical stress-based Hill model and the recent active-strain models. While the notion of active stress is rather phenomenological in nature, active strain is micro-structurally motivated, physically measurable, and straightforward to calibrate. We demonstrate that our model is capable of simulating excitation-contraction coupling in cardiac muscle with its characteristic features of wall thickening, apical lift, and ventricular torsion.

  17. MSFC Skylab airlock module, volume 2. [systems design and performance, systems support activity, and reliability and safety programs

    NASA Technical Reports Server (NTRS)

    1974-01-01

    System design and performance of the Skylab Airlock Module and Payload Shroud are presented for the communication and caution and warning systems. Crew station and storage, crew trainers, experiments, ground support equipment, and system support activities are also reviewed. Other areas documented include the reliability and safety programs, test philosophy, engineering project management, and mission operations support.

  18. Lab Safety and Bioterrorism Readiness Curricula Using Active Learning and Hands-on Strategies as Continuing Education for Medical Technologists

    PubMed Central

    Fiester, Steven; Redfearn, James; Helfinstine, Shannon; Meilander, Tracey; Woolverton, Christopher J.

    2010-01-01

    Frequent reports of laboratory- (and hospital-) acquired infection suggest a deficiency in safety training or lack of compliance. To assess the need for continuing education (CE) addressing this problem, an original education needs assessment survey was designed and administered to medical technologists (med-techs) in Northeast Ohio. Survey results were used to design a learner-centered training curriculum (for example, Lab Safety and Bioterrorism Readiness trainings) that engaged med-techs in active learning, integrative peer-to-peer teaching, and hands-on exercises in order to improve microbiology safety knowledge and associated laboratory techniques. The Lab Safety training was delivered six times and the Bioterrorism Readiness training was delivered five times. Pre/posttesting revealed significant gains in knowledge and techniques specific to laboratory safety, security, risk assessment, and bioterrorism readiness amongst the majority of med-techs completing the CE trainings. The majority of participants felt that the hands-on exercises met their needs and that their personal laboratory practices would change as a result of the training course, as measured by attitudinal surveys. We conclude that active learning techniques and peer education significantly enhance microbiology learning amongst participating med-techs. PMID:23914281

  19. Annual report to Congress: Department of Energy activities relating to the Defense Nuclear Facilities Safety Board, calendar year 1998

    SciTech Connect

    1999-02-01

    This is the ninth Annual Report to the Congress describing Department of Energy (Department) activities in response to formal recommendations and other interactions with the Defense Nuclear Facilities Safety Board (Board). The Board, an independent executive-branch agency established in 1988, provides advice and recommendations to the Secretary of energy regarding public health and safety issues at the Department`s defense nuclear facilities. The Board also reviews and evaluates the content and implementation of health and safety standards, as well as other requirements, relating to the design, construction, operation, and decommissioning of the Department`s defense nuclear facilities. The locations of the major Department facilities are provided. During 1998, Departmental activities resulted in the proposed closure of one Board recommendation. In addition, the Department has completed all implementation plan milestones associated with four other Board recommendations. Two new Board recommendations were received and accepted by the Department in 1998, and two new implementation plans are being developed to address these recommendations. The Department has also made significant progress with a number of broad-based initiatives to improve safety. These include expanded implementation of integrated safety management at field sites, a renewed effort to increase the technical capabilities of the federal workforce, and a revised plan for stabilizing excess nuclear materials to achieve significant risk reduction.

  20. Annual report to Congress: Department of Energy activities relating to the Defense Nuclear Facilities Safety Board, Calendar Year 1999

    SciTech Connect

    2000-02-01

    This is the tenth Annual Report to the Congress describing Department of Energy activities in response to formal recommendations and other interactions with the Defense Nuclear Facilities Safety Board (Board). The Board, an independent executive-branch agency established in 1988, provides advice and recommendations to the Secretary of Energy regarding public health and safety issues at the Department's defense nuclear facilities. The Board also reviews and evaluates the content and implementation of health and safety standards, as well as other requirements, relating to the design, construction, operation, and decommissioning of the Department's defense nuclear facilities. During 1999, Departmental activities resulted in the closure of nine Board recommendations. In addition, the Department has completed all implementation plan milestones associated with three Board recommendations. One new Board recommendation was received and accepted by the Department in 1999, and a new implementation plan is being developed to address this recommendation. The Department has also made significant progress with a number of broad-based initiatives to improve safety. These include expanded implementation of integrated safety management at field sites, opening of a repository for long-term storage of transuranic wastes, and continued progress on stabilizing excess nuclear materials to achieve significant risk reduction.

  1. Second-Order Perturbation Theory for Generalized Active Space Self-Consistent-Field Wave Functions.

    PubMed

    Ma, Dongxia; Li Manni, Giovanni; Olsen, Jeppe; Gagliardi, Laura

    2016-07-12

    A multireference second-order perturbation theory approach based on the generalized active space self-consistent-field (GASSCF) wave function is presented. Compared with the complete active space (CAS) and restricted active space (RAS) wave functions, GAS wave functions are more flexible and can employ larger active spaces and/or different truncations of the configuration interaction expansion. With GASSCF, one can explore chemical systems that are not affordable with either CASSCF or RASSCF. Perturbation theory to second order on top of GAS wave functions (GASPT2) has been implemented to recover the remaining electron correlation. The method has been benchmarked by computing the chromium dimer ground-state potential energy curve. These calculations show that GASPT2 gives results similar to CASPT2 even with a configuration interaction expansion much smaller than the corresponding CAS expansion. PMID:27276688

  2. The generalized active space concept in multiconfigurational self-consistent field methods.

    PubMed

    Ma, Dongxia; Li Manni, Giovanni; Gagliardi, Laura

    2011-07-28

    A multiconfigurational self-consistent field method based on the concept of generalized active space (GAS) is presented. GAS wave functions are obtained by defining an arbitrary number of active spaces with arbitrary occupation constraints. By a suitable choice of the GAS spaces, numerous ineffective configurations present in a large complete active space (CAS) can be removed, while keeping the important ones in the CI space. As a consequence, the GAS self-consistent field approach retains the accuracy of the CAS self-consistent field (CASSCF) ansatz and, at the same time, can deal with larger active spaces, which would be unaffordable at the CASSCF level. Test calculations on the Gd atom, Gd(2) molecule, and oxoMn(salen) complex are presented. They show that GAS wave functions achieve the same accuracy as CAS wave functions on systems that would be prohibitive at the CAS level. PMID:21806111

  3. A comparison of the activities and opinions of attached and employed nurses in general practice

    PubMed Central

    Reedy, B. L. E. C.; Metcalfe, A. V.; de Roumanie, M.; Newell, D. J.

    1980-01-01

    We compared the nursing and medical activities and the opinions of nurses employed by area health authorities and nurses employed by general practitioners by interviewing a random sample of 153 nurses in 113 practices, situated in four rural and five urban area health authorities in England. The availability of a treatment room profoundly affected the work of both kinds of nurse and there were differences between them in the balance between `caring' and `technical' activities which may be largely attributed to the circumstances of their employment. However, their occupational histories and choices of employer appear to reflect both differences in their training and differences in their values about career and marriage. PMID:7452582

  4. Systems analysis of the installation, mounting, and activation of emergency locator transmitters in general aviation aircraft

    NASA Technical Reports Server (NTRS)

    Hall, D. S.

    1980-01-01

    A development program was developed to design and improve the Emergency Locator Transmitter (ELT) transmitter and to improve the installation in the aircraft and its activation subsystem. There were 1135 general aviation fixed wing aircraft accident files reviewed. A detailed description of the damage to the aircraft was produced. The search aspects of these accidents were studied. As much information as possible about the ELT units in these cases was collected. The data should assist in establishing installation and mounting criteria, better design standards for activation subsystems, and requirements for the new ELT system design in the area of crashworthiness.

  5. Issues and challenges for pedestrian active safety systems based on real world accidents.

    PubMed

    Hamdane, Hédi; Serre, Thierry; Masson, Catherine; Anderson, Robert

    2015-09-01

    The purpose of this study was to analyze real crashes involving pedestrians in order to evaluate the potential effectiveness of autonomous emergency braking systems (AEB) in pedestrian protection. A sample of 100 real accident cases were reconstructed providing a comprehensive set of data describing the interaction between the vehicle, the environment and the pedestrian all along the scenario of the accident. A generic AEB system based on a camera sensor for pedestrian detection was modeled in order to identify the functionality of its different attributes in the timeline of each crash scenario. These attributes were assessed to determine their impact on pedestrian safety. The influence of the detection and the activation of the AEB system were explored by varying the field of view (FOV) of the sensor and the level of deceleration. A FOV of 35° was estimated to be required to detect and react to the majority of crash scenarios. For the reaction of a system (from hazard detection to triggering the brakes), between 0.5 and 1s appears necessary. PMID:26047007

  6. 77 FR 58567 - Information Collection Activities: Well Control and Production Safety Training, Submitted for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-21

    ... of the paperwork requirements in the regulations under Subpart O, ``Well Control and Production... 250, Subpart O, Well Control and Production Safety Training. OMB Control Number: 1014-0008. Abstract... 30 CFR part 250, subpart O, Well Control and Production Safety Training. Responses are mandatory...

  7. 25 CFR 170.141 - What Federal funds are available for a tribe's highway safety activities?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... from the U.S. Department of Health and Human Services (HHS); (g) Indian Highway Safety Program 25 CFR... program funds under 23 U.S.C. 405; (d) Alcohol traffic safety program funds under 23 U.S.C. 408;...

  8. 75 FR 30783 - Agency Information Collection Activities; Proposed Collection; Comment Request; Safety Standard...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... for Infant Bath Seats AGENCY: Consumer Product Safety Commission. ACTION: Notice. SUMMARY: The... Standard for Infant Bath Seats. DATES: Submit written or electronic comments on the collection of... appropriate, and other forms of information technology. Title: Safety Standard for Infant Bath Seats--16...

  9. Getting There! Mini-Units and Learning Activities on Transportation Safety for Grades 6 through 9.

    ERIC Educational Resources Information Center

    Wolff, Peter; And Others

    One of a series of eleven curriculum manuals which cover the four transportation topics of public transportation, transportation and the environment, transportation safety, and bicycles for elementary, secondary, and adult levels, this manual covers the transportation safety topic for grades 6-9. The manual contains forty-seven learning activities…

  10. 29 CFR 500.103 - Activities not subject to vehicle safety standards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... LABOR REGULATIONS MIGRANT AND SEASONAL AGRICULTURAL WORKER PROTECTION Motor Vehicle Safety and Insurance for Transportation of Migrant and Seasonal Agricultural Workers, Housing Safety and Health for Migrant... not apply to an individual migrant or seasonal agricultural worker when the only other occupants...

  11. 29 CFR 500.103 - Activities not subject to vehicle safety standards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... LABOR REGULATIONS MIGRANT AND SEASONAL AGRICULTURAL WORKER PROTECTION Motor Vehicle Safety and Insurance for Transportation of Migrant and Seasonal Agricultural Workers, Housing Safety and Health for Migrant... not apply to an individual migrant or seasonal agricultural worker when the only other occupants...

  12. 77 FR 57156 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Safety...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... Register on June 1, 2012 (77 FR 32698). Interested parties are encouraged to send comments to the OMB...; Safety Standards for Roof Bolts in Metal and Nonmetal Mines and Underground Coal Mines ACTION: Notice. SUMMARY: The Department of Labor (DOL) is submitting the Mine Safety and Health Administration...

  13. Getting There! Mini-Units and Learning Activities on Transportation Safety for Grades 9 through 12.

    ERIC Educational Resources Information Center

    Wolff, Peter; And Others

    One of a series of eleven curriculum manuals which cover the four transportation topics of public transportation, transportation and the environment, transportation safety, and bicycles for elementary, secondary, and adult levels, this manual covers the transportation safety topic for grades 9-12. It contains forty-three learning activities…

  14. A General Method for Multimetallic Platinum Alloy Nanowires as Highly Active and Stable Oxygen Reduction Catalysts.

    PubMed

    Bu, Lingzheng; Ding, Jiabao; Guo, Shaojun; Zhang, Xu; Su, Dong; Zhu, Xing; Yao, Jianlin; Guo, Jun; Lu, Gang; Huang, Xiaoqing

    2015-11-25

    An unconventional class of high-performance Pt alloy multimetallic nanowires (NWs) is produced by a general method. The obtained PtNi NWs exhibit amazingly specific and mass oxygen reduction reaction (ORR) activities with improvement factors of 51.1 and 34.6 over commercial Pt/C catalysts, respectively, and are also stable in ORR conditions, making them among the most efficient electrocatalysts for ORR. PMID:26459261

  15. A simplified method for quantitative assessment of the relative health and safety risk of environmental management activities

    SciTech Connect

    Eide, S.A.; Smith, T.H.; Peatross, R.G.; Stepan, I.E.

    1996-09-01

    This report presents a simplified method to assess the health and safety risk of Environmental Management activities of the US Department of Energy (DOE). The method applies to all types of Environmental Management activities including waste management, environmental restoration, and decontamination and decommissioning. The method is particularly useful for planning or tradeoff studies involving multiple conceptual options because it combines rapid evaluation with a quantitative approach. The method is also potentially applicable to risk assessments of activities other than DOE Environmental Management activities if rapid quantitative results are desired.

  16. A randomized clinical trial comparing the efficacy and safety of ramosetron versus ondansetron in patients undergoing abdominal surgery under general anesthesia

    PubMed Central

    Kaja, Sriramamurthy; Giri, Ravindra S.; Tugave, Deepak V.; Iqbal, Mukarram

    2014-01-01

    Background: Post-operative nausea and vomiting is one of the most common and distressing complications after anesthesia and surgery. It may lead to serious post-operative complications. Ramosetron is a newer 5-HT3 receptor antagonist and has more potent and longer duration of antiemetic effects compared to first generation 5HT3 receptor antagonists. The purpose of this study was to compare the efficacy of Ramosetron for the prevention of post-operative nausea and vomiting with that of Ondansetron in patients undergoing abdominal surgeries under general anesthesia. Methods: In this randomized, double-blind study, 60 patients, 18-60 years of both genders falling under ASA I-II category scheduled for abdominal surgery were included. Group I received I.V ramosetron 0.3 mg while group II received I.V Ondansetron 4 mg at the time of extubation. The standard general anesthetic technique was used throughout. Postoperatively the incidences of nausea, vomiting, and safety assessments were performed at 1, 2, 6, and 24 h during the first 24 h after surgery. Results: There were no differences between groups with respect to patient demographics. The percentage of patients who had complete response (no PONV, and no need for another rescue antiemetic) from 0 to 24 h after anesthesia was 56% with ramosetron and 33% with ondansetron. The corresponding rates at 1, 2, 6, and 24 h after anesthesia were 76% and 63%, 76% and 50%, 100 and 83%, 100 and 93%, respectively. Safety profiles of the two drugs were comparable, as no clinically serious adverse effects caused by study drugs were observed in either of the groups. Conclusion: Our study concludes that prophylactic therapy with ramosetron is highly efficacious than ondansetron in preventing PONV in patients undergoing abdominal surgery under general anesthesia. PMID:24665241

  17. Inflammatory Cytokines in General and Central Obesity and Modulating Effects of Physical Activity

    PubMed Central

    Sander, Christian; Minkwitz, Juliane; Thormann, Julia; Chittka, Tobias; Mergl, Roland; Kirkby, Kenneth C.; Faßhauer, Mathias; Stumvoll, Michael; Holdt, Lesca M.; Teupser, Daniel; Hegerl, Ulrich; Himmerich, Hubertus

    2015-01-01

    Context Chronic systemic inflammation in obesity originates from local immune responses in visceral adipose tissue. However, assessment of a broad range of inflammation-mediating cytokines and their relationship to physical activity and adipometrics has scarcely been reported to date. Objective To characterize the profile of a broad range of pro- and anti-inflammatory cytokines and the impact of physical activity and energy expenditure in individuals with general obesity, central obesity, and non-obese subjects. Design, Setting, and Participants A cross-sectional study comprising 117 obese patients (body mass index (BMI) ≥ 30) and 83 non-obese community-based volunteers. Main Outcomes Measures Serum levels of interleukin (IL)-2, IL-4, IL-5, IL-10, IL-12, IL-13, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon (IFN)-γ and tumor necrosis factor (TNF)-α were measured. Physical activity and energy expenditure (MET) were assessed with actigraphy. Adipometrics comprised BMI, weight, abdominal-, waist- and hip-circumference, waist to hip ratio (WHR), and waist-to-height-ratio (WHtR). Results General obesity was associated with significantly elevated levels of IL-5, IL-10, IL-12, IL-13, IFN-γ and TNF-α, central obesity with significantly elevated IL-5, IL-10, IL-12, IL-13 and IFN-γ-levels. In participants with general obesity, levels of IL-4, IL-10 and IL-13 were significantly elevated in participants with low physical activity, even when controlled for BMI which was negatively associated with physical acitivity. Cytokines significantly correlated with adipometrics, particularly in obese participants. Conclusions Results confirm up-regulation of certain pro- and anti-inflammatory cytokines in obesity. In obese subjects, physical activity may lower levels and thus reduce pro-inflammatory effects of cytokines that may link obesity, insulin resistance and diabetes. PMID:25781614

  18. Long-term safety evaluation of bimatoprost ophthalmic solution 0.03%: a pooled analysis of six double-masked, randomized, active-controlled clinical trials

    PubMed Central

    Wirta, David; VanDenburgh, Amanda M; Weng, Emily; Whitcup, Scott M; Kurstjens, Sef; Beddingfield, Frederick C

    2011-01-01

    Background: Bimatoprost ophthalmic solution 0.03% was approved in the US for reducing intraoccular pressure (IOP) based on two double-masked, active-controlled clinical trials. Four additional long-term studies (≥12 months) were conducted; however, the aggregate safety profile of the six studies has not been reported. Methods: Adverse events (AEs) were pooled from six double-masked, active-controlled, long-term clinical trials in which subjects received bimatoprost 0.03% once daily (QD) or twice daily (BID) as an eyedrop. AE terms were converted to MedDRA (V.11.0) Preferred Terms and analyzed. Results: In total, 1409 patients received more than one dose of bimatoprost 0.03% QD or BID. Most AEs were mild in severity and reported by 86.7% (QD) and 94.8% (BID) of subjects (≤12 months of treatment). AEs reported through month 12 (aggregate incidence of ≥5%) were conjunctival hyperemia, increased eyelash growth, eye pruritus, periocular skin hyperpigmentation, eye irritation, dry eye, and hypertrichosis. AE onset was generally reported within four months of treatment. The cumulative incidence of common AEs in the QD treatment group at 24–48 months was similar to that measured at 12 months of treatment. Conclusion: Bimatoprost 0.03% has a favorable safety and tolerability profile as characterized by six long-term studies. Common AEs were due to the known pharmacological activity of bimatoprost and reversible with treatment cessation. PMID:21691584

  19. 10 CFR 835.3 - General rule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false General rule. 835.3 Section 835.3 Energy DEPARTMENT OF ENERGY OCCUPATIONAL RADIATION PROTECTION General Provisions § 835.3 General rule. (a) No person or DOE... actions that may be necessary to protect health and safety. (e) For those activities that are required...

  20. 10 CFR 835.3 - General rule.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false General rule. 835.3 Section 835.3 Energy DEPARTMENT OF ENERGY OCCUPATIONAL RADIATION PROTECTION General Provisions § 835.3 General rule. (a) No person or DOE... actions that may be necessary to protect health and safety. (e) For those activities that are required...

  1. Does an activity based remuneration system attract young doctors to general practice?

    PubMed Central

    2012-01-01

    Background The use of increasingly complex payment schemes in primary care may represent a barrier to recruiting general practitioners (GP). The existing Norwegian remuneration system is fully activity based - 2/3 fee-for-service and 1/3 capitation. Given that the system has been designed and revised in close collaborations with the medical association, it is likely to correspond - at least to some degree - with the preferences of current GPs (men in majority). The objective of this paper was to study which preferences that young doctors (women in majority), who are the potential entrants to general practice have for activity based vs. salary based payment systems. Methods In November-December 2010 all last year medical students and all interns in Norway (n = 1.562) were invited to participate in an online survey. The respondents were asked their opinion on systems of remuneration for GPs; inclination to work as a GP; risk attitude; income preferences; work pace tolerance. The data was analysed using one-way ANOVA and multinomial logistic regression analysis. Results A total of 831 (53%) responded. Nearly half the sample (47%) did not consider the remuneration system to be important for their inclination to work as GP; 36% considered the current system to make general practice more attractive, while 17% considered it to make general practice less attractive. Those who are attracted by the existing system were men and those who think high income is important, while those who are deterred by the system are risk averse and less happy with a high work pace. On the question of preferred remuneration system, half the sample preferred a mix of salary and activity based remuneration (the median respondent would prefer a 50/50 mix). Only 20% preferred a fully activity based system like the existing one. A salary system was preferred by women, and those less concerned with high income, while a fully activity based system was preferred by men, and those happy with a high work

  2. An overview of research activities on materials for nuclear applications at the INL Safety, Tritium and Applied Research facility

    NASA Astrophysics Data System (ADS)

    Calderoni, P.; Sharpe, J.; Shimada, M.; Denny, B.; Pawelko, B.; Schuetz, S.; Longhurst, G.; Hatano, Y.; Hara, M.; Oya, Y.; Otsuka, T.; Katayama, K.; Konishi, S.; Noborio, K.; Yamamoto, Y.

    2011-10-01

    The Safety, Tritium and Applied Research facility at the Idaho National Laboratory is a US Department of Energy National User Facility engaged in various aspects of materials research for nuclear applications related to fusion and advanced fission systems. Research activities are mainly focused on the interaction of tritium with materials, in particular plasma facing components, liquid breeders, high temperature coolants, fuel cladding, cooling and blanket structures and heat exchangers. Other activities include validation and verification experiments in support of the Fusion Safety Program, such as beryllium dust reactivity and dust transport in vacuum vessels, and support of Advanced Test Reactor irradiation experiments. This paper presents an overview of the programs engaged in the activities, which include the US-Japan TITAN collaboration, the US ITER program, the Next Generation Power Plant program and the tritium production program, and a presentation of ongoing experiments as well as a summary of recent results with emphasis on fusion relevant materials.

  3. An overview of research activities on materials for nuclear applications at the INL Safety, Tritium and Applied Research facility

    SciTech Connect

    P. Calderoni; P. Sharpe; M. Shimada

    2009-09-01

    The Safety, Tritium and Applied Research facility at the Idaho National Laboratory is a US Department of Energy National User Facility engaged in various aspects of materials research for nuclear applications related to fusion and advanced fission systems. Research activities are mainly focused on the interaction of tritium with materials, in particular plasma facing components, liquid breeders, high temperature coolants, fuel cladding, cooling and blanket structures and heat exchangers. Other activities include validation and verification experiments in support of the Fusion Safety Program, such as beryllium dust reactivity and dust transport in vacuum vessels, and support of Advanced Test Reactor irradiation experiments. This paper presents an overview of the programs engaged in the activities, which include the US-Japan TITAN collaboration, the US ITER program, the Next Generation Power Plant program and the tritium production program, and a presentation of ongoing experiments as well as a summary of recent results with emphasis on fusion relevant materials.

  4. Hand Safety

    MedlinePlus

    ... en gatillo See More... Hand Anatomy Hand Safety Fireworks Safety Lawnmower Safety Snowblower safety Pumpkin Carving Gardening ... en gatillo See More... Hand Anatomy Hand Safety Fireworks Safety Lawnmower Safety Snowblower safety Pumpkin Carving Gardening ...

  5. Hand Safety

    MedlinePlus

    ... Fireworks Safety Lawnmower Safety Snowblower safety Pumpkin Carving Gardening Safety Turkey Carving Removing a Ring Español Artritis ... Fireworks Safety Lawnmower Safety Snowblower safety Pumpkin Carving Gardening Safety Turkey Carving Removing a Ring Español Artritis ...

  6. Quality and Safety of General Anesthesia with Propofol and Sevoflurane in Children Aged 1-14 Based on Laboratory Parameters

    PubMed Central

    Vanis-Vatrenjak, Selma; Mesic, Amira; Abdagic, Ines; Mujezinovic, Djenita; Zvizdic, Zlatan

    2015-01-01

    Introduction: Knowledge of anatomic, physiological, biochemical and physical characteristics of children of all age groups, the existing illness and possible pathological response of the organism to the existing situation, require a pediatric anesthesiologist to participate in the preparation of a child for surgical treatment, to choose the best anesthesia technique and medications, and manipulative techniques to enable the scheduled surgical treatment with minimum anesthesia risks. The aim of this clinical study was to prove reliability and quality of propofol or sevoflurane general anesthesia in children in the age group of 1-14 years from the ASA I group and in the elective surgical treatments in duration of 60 minutes, based on preoperative and postoperative levels of laboratory findings (transaminases, blood sugar, urea and creatinine). Materials and methods: the study included 160 patients randomized in two groups based on different approaches: total intravenous anesthesia was used for the propofol group (n=80) (TIVA) and the inhalation technique was used for the sevoflurane group (n=80). Results: statistical evaluation of the obtained results indicates stability of laboratory findings in the immediate postoperative course (after 24 hours) in respect to the preoperative period. Based on the Mann Whitney test (P), preoperative and postoperative blood sugar levels in the sevoflurane vs. propofol group were P=0.152 vs. 0.021; creatinine levels P=0.113 vs. 0.325; urea levels P= 0.016 vs. 0.900; AST levels P=0,031 vs. 0,268 and ALT levels P=0.021 vs. 0.058. Level of significance was P<0.5. Conclusion: Analysis of the examined laboratory parameters show that propofol and sevoflurane provide full security and quality of general anesthesia in children age group 1-14 years, from the ASA I group. All analyzed laboratory levels in the postoperative course remained in their referential values in both groups of participants. PMID:26543304

  7. Electromagnetic Safety of Spacecraft During Active Experiments with the Use of Plasma Accelerators and Ion Injectors

    NASA Astrophysics Data System (ADS)

    Plokhikh, Andrey; Popov, Garri; Shishkin, Gennady; Antropov, Nikolay; Vazhenin, Nikolay; Soganova, Galina

    Works under the development and application of stationary and pulsed plasma accelerators of charged particles conducted at the Moscow Aviation Institute and Research Institute of Applied Mechanics and Electrodynamics during over 40 years, active experiments on board meteorological rockets, artificial Earth satellites and "Mir" orbital station including [1], allowed to obtain data on the influence of pulsed and continuous plasma injection with the given parameters on the drop of energetic particles out of the radiation belts, efficiency of artificial excitation and propagation of electromagnetic waves in ELF and VLF ranges, and evolution of artificial plasma formations in different regions of ionosphere. Variation of the near-spacecraft electromagnetic environment related to the operation of plasma injectors was registered during active experiments along with the global electrodynamic processes. The measured electromagnetic fields are of rather high intensity and occupy frequency spectrum from some Hz to tens of GHz that may be of definite danger for the operation of spacecraft and its onboard systems. Analysis for the known test data is presented in the paper and methods are discussed for the diagnostics and modeling under laboratory conditions of radiative processes proceeding at the operation of plasma accelerators and ion injectors used while making active space experiments. Great attention is paid to the methodological and metrological bases for making radio measurements in vacuum chambers, design concept and hardware configuration of ground special-purpose instrumentation scientific complexes [2]. Basic requirements are formulated for the measurements and analysis of electromagnetic fields originating during the operation of plasma accelerators, including the radiative induced and conductive components inside the spacecraft, as well as the wave emission and excitation outside the spacecraft, in the ionosphere including. Measurement results for the intrinsic

  8. Space reactor safety, 1985--1995 lessons learned

    SciTech Connect

    Marshall, A.C.

    1995-12-31

    Space reactor safety activities and decisions have evolved over the last decade. Important safety decisions have been made in the SP-100, Space Exploration Initiative, NEPSTP, SNTP, and Bimodal Space Reactor programs. In addition, international guidance on space reactor safety has been instituted. Space reactor safety decisions and practices have developed in the areas of inadvertent criticality, reentry, radiological release, orbital operation, programmatic, and policy. In general, the lessons learned point out the importance of carefully reviewing previous safety practices for appropriateness to space nuclear programs in general and to the specific mission under consideration.

  9. Suboptimal Muscle Synergy Activation Patterns Generalize their Motor Function across Postures

    PubMed Central

    Sohn, M. Hongchul; Ting, Lena H.

    2016-01-01

    muscles associated with producing a specific synergy force vector was reduced by ~45% when generalizability requirements were imposed. Muscles recruited in the generalizable muscle activation patterns had less sensitive torque-producing characteristics to changes in postures. We conclude that generalization of function across postures does not arise from limb biomechanics or a single optimality criterion. Muscle synergies may reflect acquired motor solutions globally tuned for generalizability across biomechanical contexts, facilitating rapid motor adaptation. PMID:26869914

  10. Activation of Hypoxia Inducible Factor 1 Is a General Phenomenon in Infections with Human Pathogens

    PubMed Central

    Werth, Nadine; Beerlage, Christiane; Rosenberger, Christian; Yazdi, Amir S.; Edelmann, Markus; Amr, Amro; Bernhardt, Wanja; von Eiff, Christof; Becker, Karsten; Schäfer, Andrea; Peschel, Andreas; Kempf, Volkhard A. J.

    2010-01-01

    Background Hypoxia inducible factor (HIF)-1 is the key transcriptional factor involved in the adaptation process of cells and organisms to hypoxia. Recent findings suggest that HIF-1 plays also a crucial role in inflammatory and infectious diseases. Methodology/Principal Findings Using patient skin biopsies, cell culture and murine infection models, HIF-1 activation was determined by immunohistochemistry, immunoblotting and reporter gene assays and was linked to cellular oxygen consumption. The course of a S. aureus peritonitis was determined upon pharmacological HIF-1 inhibition. Activation of HIF-1 was detectable (i) in all ex vivo in biopsies of patients suffering from skin infections, (ii) in vitro using cell culture infection models and (iii) in vivo using murine intravenous and peritoneal S. aureus infection models. HIF-1 activation by human pathogens was induced by oxygen-dependent mechanisms. Small colony variants (SCVs) of S. aureus known to cause chronic infections did not result in cellular hypoxia nor in HIF-1 activation. Pharmaceutical inhibition of HIF-1 activation resulted in increased survival rates of mice suffering from a S. aureus peritonitis. Conclusions/Significance Activation of HIF-1 is a general phenomenon in infections with human pathogenic bacteria, viruses, fungi and protozoa. HIF-1-regulated pathways might be an attractive target to modulate the course of life-threatening infections. PMID:20644645

  11. Differential Neural Activity during Search of Specific and General Autobiographical Memories elicited by Musical Cues

    PubMed Central

    Ford, Jaclyn Hennessey; Addis, Donna Rose; Giovanello, Kelly S.

    2011-01-01

    Previous neuroimaging studies that have examined autobiographical memory specificity have utilized retrieval cues associated with prior searches of the event, potentially changing the retrieval processes being investigated. In the current study, musical cues were used to naturally elicit memories from multiple levels of specificity (i.e., lifetime period, general event, and event-specific). Sixteen young adults participated in a neuroimaging study in which they retrieved autobiographical memories associated with musical cues. These musical cues led to the retrieval of highly emotional memories that had low levels of prior retrieval. Retrieval of all autobiographical memory levels was associated with activity in regions in the autobiographical memory network, specifically the ventromedial prefrontal cortex, posterior cingulate, and right medial temporal lobe. Owing to the use of music, memories from varying levels of specificity were retrieved, allowing for comparison of event memory and abstract personal knowledge, as well as comparison of specific and general event memory. Dorsolateral and dorsomedial prefrontal regions were engaged during event retrieval relative to personal knowledge retrieval, and retrieval of specific event memories was associated with increased activity in the bilateral medial temporal lobe and dorsomedial prefrontal cortex relative to retrieval of general event memories. These results suggest that the initial search processes for memories of different specificity levels preferentially engage different components of the autobiographical memory network. The potential underlying causes of these neural differences are discussed. PMID:21600227

  12. Interruptions of nurses' activities and patient safety: an integrative literature review1

    PubMed Central

    Monteiro, Cintia; Avelar, Ariane Ferreira Machado; Pedreira, Mavilde da Luz Gonçalves

    2015-01-01

    OBJECTIVES: to identify characteristics related to the interruption of nurses in professional practice, as well as to assess the implications of interruptions for patient safety. METHOD: integrative literature review. The following databases were searched: Pubmed/Medline, LILACS, SciELO and Cochrane Library, using the descriptors interruptions and patient safety. An initial date was not established, but the final date was December 31, 2013. A total of 29 papers met the inclusion criteria. RESULTS: all the papers included describe interruptions as a harmful factor for patient safety. Data analysis revealed three relevant categories: characteristics of interruptions, implications for patient safety, and interventions to minimize interruptions. CONCLUSION: interruptions favor the occurrence of errors in the health field. Therefore, there is a need for further studies to understand such a phenomenon and its effects on clinical practice. PMID:25806646

  13. Fire safety applications for spacecraft

    NASA Technical Reports Server (NTRS)

    Friedman, Robert; Olson, Sandra L.

    1989-01-01

    Fire safety for spacecraft is reviewed by first describing current practices, many of which are adapted directly from aircraft. Then, current analyses and experimental knowledge in low-gravity combustion, with implications for fire safety are discussed. In orbiting spacecraft, the detection and suppression of flames are strongly affected by the large reduction in buoyant flows under low gravity. Generally, combustion intensity is reduced in low gravity. There are some notable exceptions, however, one example being the strong enhancement of flames by low-velocity ventilation flows in space. Finally, the future requirements in fire safety, particularly the needs of long-duration space stations in fire prevention, detection, extinguishment, and atmospheric control are examined. The goal of spacecraft fire-safety investigations is the establishment of trade-offs that promote maximum safety without hampering the useful human and scientific activities in space.

  14. Safety and prolonged activity of recombinant factor VIII Fc fusion protein in hemophilia A patients

    PubMed Central

    Josephson, Neil C.; Quon, Doris; Ragni, Margaret V.; Cheng, Gregory; Li, Ella; Jiang, Haiyan; Li, Lian; Dumont, Jennifer A.; Goyal, Jaya; Zhang, Xin; Sommer, Jurg; McCue, Justin; Barbetti, Margaret; Luk, Alvin

    2012-01-01

    Current factor VIII (FVIII) products display a half-life (t1/2) of ∼ 8-12 hours, requiring frequent intravenous injections for prophylaxis and treatment of patients with hemophilia A. rFVIIIFc is a recombinant fusion protein composed of a single molecule of FVIII covalently linked to the Fc domain of human IgG1 to extend circulating rFVIII t1/2. This first-in-human study in previously treated subjects with severe hemophilia A investigated safety and pharmacokinetics of rFVIIIFc. Sixteen subjects received a single dose of rFVIII at 25 or 65 IU/kg followed by an equal dose of rFVIIIFc. Most adverse events were unrelated to study drug. None of the study subjects developed anti-rFVIIIFc antibodies or inhibitors. Across dose levels, compared with rFVIII, rFVIIIFc showed 1.54- to 1.70-fold longer elimination t1/2, 1.49- to 1.56-fold lower clearance, and 1.48- to 1.56-fold higher total systemic exposure. rFVIII and rFVIIIFc had comparable dose-dependent peak plasma concentrations and recoveries. Time to 1% FVIII activity above baseline was ∼ 1.53- to 1.68-fold longer than rFVIII across dose levels. Each subject showed prolonged exposure to rFVIIIFc relative to rFVIII. Thus, rFVIIIFc may offer a viable therapeutic approach to achieve prolonged hemostatic protection and less frequent dosing in patients with hemophilia A. This trial was registered at www.clinicaltrials.gov as NCT01027377. PMID:22223821

  15. [Anti-counterfeit activities of pharmaceutical companies in Japan: for patient safety].

    PubMed

    Shofuda, Ken-ichi; Aragane, Katsumi; Igari, Yasutaka; Matsumoto, Kinya; Ito, Kazuya

    2014-01-01

    Global spread of counterfeit medicines is an imminent threat for the patients' safety. Although major targets of counterfeits are still erectile dysfunction (ED) drugs in the industrialized countries, including Japan, anti-cancer agents and some medicines for metabolic syndromes are also being counterfeited and circulated to the market mainly through the Internet. Due to the global expansion of the business, pharmaceutical companies based in Japan are suffering from the damage of counterfeits, illegal sales including diversion, and thefts, which have never been experienced in the conventional domestic market. We, pharmaceutical companies, must be responsible for the prevention of the prevalence because our mission is to deliver effective and safe medicine to patients. For this end, we are taking necessary actions including, 1. Forestalling counterfeit, falsification and illicit trade: Measures to prevent counterfeiting are taken by introducing anti-counterfeit technologies to the packaging and tablets on a risk basis. It is also important to establish supply chain security on a global scale. 2. Finding out counterfeits and cooperating crackdown: We are conducting market and internet surveillances when high risk products are sold in high risk markets. The outcome of the criminal investigation is reported to authorities and police if necessary. 3. Conducting educational campaign to medical staff or patients: For example, four companies which manufacture and sell ED drug in Japan are collaboratively continuing activities to raise the awareness of the danger of Internet purchase. To deliver effective and safe medicines stably and globally, pharmaceutical companies extend comprehensive measures against counterfeit and illicit trading. PMID:24492224

  16. Evaluating the Safety of Retroviral Vectors Based on Insertional Oncogene Activation and Blocked Differentiation in Cultured Thymocytes

    PubMed Central

    Zhou, Sheng; Fatima, Soghra; Ma, Zhijun; Wang, Yong-Dong; Lu, Taihe; Janke, Laura J; Du, Yang; Sorrentino, Brian P

    2016-01-01

    Insertional oncogenesis due to retroviral (RV) vector integration has caused recurrent leukemia in multiple gene therapy trials, predominantly due to vector integration effects at the LMO2 locus. While currently available preclinical safety models have been used for evaluating vector safety, none have predicted or reproduced the recurrent LMO2 integrations seen in previous X-linked severe combined immunodeficiency (X-SCID) and Wiskott–Aldrich clinical gene therapy trials. We now describe a new assay for assessing vector safety that recapitulates naturally occurring insertions into Lmo2 and other T-cell proto-oncogenes leading to a preleukemic developmental arrest in primary murine thymocytes cultured in vitro. This assay was used to compare the relative oncogenic potential of a variety of gamma-RV and lentiviral vectors and to assess the risk conferred by various transcriptional elements contained in these genomes. Gamma-RV vectors that contained full viral long-terminal repeats were most prone to causing double negative 2 (DN2) arrest and led to repeated cases of Lmo2 pathway activation, while lentiviral vectors containing these same elements were significantly less prone to activate proto-oncogenes or cause DN2 arrest. This work provides a new preclinical assay that is especially relevant for assessing safety in SCID disorders and provides a new tool for designing safer RV vectors. PMID:26957223

  17. Light-Intensity Physical Activities and Mortality in the United States General Population and CKD Subpopulation

    PubMed Central

    Wei, Guo; Marcus, Robin L.; Chonchol, Michel; Greene, Tom

    2015-01-01

    Background and objectives Sedentary behavior is associated with increased mortality in the general population. Whether replacing sedentary behavior with low- or light-intensity activities confers a survival benefit in the general or CKD populations is unknown. Design, setting, participants, & measurements This observational analysis of the 2003–2004 National Health and Nutrition Examination Survey examined the associations of low- and light-intensity activities with mortality. On the basis of the number of counts/min recorded by an accelerometer, durations of sedentary (<100/min), low (100–499/min), light (500–2019/min), and moderate/vigorous (≥2020/min) activity were defined and normalized to 60 minutes. The mortality associations of 2 min/hr less sedentary duration in conjunction with 2 min/hr more (tradeoff) spent in one of the low, light, or moderate/vigorous activity durations while controlling for the other two activity durations were examined in multivariable Cox regression models in the entire cohort and in the CKD subgroup. Results Of the 3626 participants included, 383 had CKD. The mean sedentary duration was 34.4±7.9 min/hr in the entire cohort and 40.8±6.8 in the CKD subgroup. Tradeoff of sedentary duration with low activity duration was not associated with mortality in the entire cohort or the CKD subgroup. Tradeoff of sedentary duration with light activity duration was associated with a lower hazard of death in the entire cohort (hazard ratio, 0.67; 95% confidence interval, 0.48 to 0.93) and CKD subgroup (hazard ratio, 0.59; 95% confidence interval, 0.35 to 0.98). Tradeoff of sedentary duration with moderate/vigorous activity duration had a nonsignificant lower hazard in the entire cohort and CKD subgroup. Conclusions Patients with CKD are sedentary nearly two thirds of the time. Interventions that replace sedentary duration with an increase in light activity duration might confer a survival benefit. PMID:25931456

  18. Safety Precautions for Science.

    ERIC Educational Resources Information Center

    Folks, John; And Others

    Safety information is discussed and outlined in this guide. Areas include: (1) general laboratory safety rules; (2) general rules and guidelines for animals in the elementary classroom; (3) general guidelines for the physical sciences; (4) general rules for using animals in investigations, with specifics on the care and handling of mammals,…

  19. Safety: An Attitude

    ERIC Educational Resources Information Center

    Smith, Harry T.

    1978-01-01

    Describes eight safety concepts developed by the author to teach safety and accident prevention in industrial arts shops and to promote more positive student attitudes toward shop safety. Stressing several general safety concepts instead of requiring dozens of rules has been found to work. (MF)

  20. Activation of D1 dopamine receptors induces emergence from isoflurane general anesthesia

    PubMed Central

    Taylor, Norman E.; Chemali, Jessica J.; Brown, Emery N.; Solt, Ken

    2012-01-01

    BACKGROUND A recent study showed that methylphenidate induces emergence from isoflurane anesthesia. Methylphenidate inhibits dopamine and norepinephrine reuptake transporters. The objective of this study was to test the hypothesis that selective dopamine receptor activation induces emergence from isoflurane anesthesia. METHODS In adult rats, we tested the effects of chloro-APB (D1 agonist) and quinpirole (D2 agonist) on time to emergence from isoflurane general anesthesia. We then performed a dose–response study to test for chloro-APB-induced restoration of righting during continuous isoflurane anesthesia. SCH-23390 (D1 antagonist) was used to confirm that the effects induced by chloro-APB are specifically mediated by D1 receptors. In a separate group of animals, spectral analysis was performed on surface electroencephalogram recordings to assess neurophysiological changes induced by chloro-APB and quinpirole during isoflurane general anesthesia. RESULTS Chloro-APB decreased median time to emergence from 330s to 50s. The median difference in time to emergence between the saline control group (n=6) and the chloro-APB group (n = 6) was 222s (95% CI: 77–534s, Mann-Whitney test). This difference was statistically significant (p = 0.0082). During continuous isoflurane anesthesia, chloro-APB dose-dependently restored righting (n = 6) and decreased electroencephalogram delta power (n = 4). These effects were inhibited by pretreatment with SCH-23390. Quinpirole did not restore righting (n = 6) and had no significant effect on the electroencephalogram (n = 4) during continuous isoflurane anesthesia. CONCLUSIONS Activation of D1 receptors by chloro-APB decreases time to emergence from isoflurane anesthesia, and produces behavioral and neurophysiological evidence of arousal during continuous isoflurane anesthesia. These findings suggest that selective activation of a D1 receptor-mediated arousal mechanism is sufficient to induce emergence from isoflurane general

  1. 78 FR 12676 - Timing Requirements for the Submission of a Site Assessment Plan (SAP) or General Activities Plan...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... test.'' (71 FR 788 (2006)). OCSLA, however, uses the term ``Affected State'' to identify which States... Submission of a Site Assessment Plan (SAP) or General Activities Plan (GAP) for a Renewable Energy Project on... Assessment Plan (SAP) or General Activities Plan (GAP) pursuant to the regulations governing renewable...

  2. Action Memorandum for General Decommissioning Activities under the Idaho Cleanup Project

    SciTech Connect

    S. L. Reno

    2006-10-26

    This Action Memorandum documents the selected alternative to perform general decommissioning activities at the Idaho National Laboratory (INL) under the Idaho Cleanup Project (ICP). Preparation of this Action Memorandum has been performed in accordance with the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), as amended by the "Superfund Amendments and Reauthorization Act of 1986", and in accordance with the "National Oil and Hazardous Substances Pollution Contingency Plan". An engineering evaluation/cost analysis (EE/CA) was prepared and released for public comment and evaluated alternatives to accomplish the decommissioning of excess buildings and structures whose missions havve been completed.

  3. Clinical Safety of a High Dose of Phycocyanin-Enriched Aqueous Extract from Arthrospira (Spirulina) platensis: Results from a Randomized, Double-Blind, Placebo-Controlled Study with a Focus on Anticoagulant Activity and Platelet Activation

    PubMed Central

    Drapeau, Cassandra; Lenninger, Miki; Benson, Kathleen F.

    2016-01-01

    Abstract The goal for this study was to evaluate safety regarding anticoagulant activity and platelet activation during daily consumption of an aqueous cyanophyta extract (ACE), containing a high dose of phycocyanin. Using a randomized, double-blind, placebo-controlled study design, 24 men and women were enrolled after informed consent, and consumed either ACE (2.3 g/day) or placebo daily for 2 weeks. The ACE dose was equivalent to ∼1 g phycocyanin per day, chosen based on the highest dose Generally Recognized as Safe (GRAS) by the U.S. Food and Drug Administration. Consuming ACE did not alter markers for platelet activation (P-selectin expression) or serum P-selectin levels. No changes were seen for activated partial thromboplastin time, thrombin clotting time, or fibrinogen activity. Serum levels of aspartate transaminase (AST) showed a significant reduction after 2 weeks of ACE consumption (P < .001), in contrast to placebo where no changes were seen; the difference in AST levels between the two groups was significant at 2 weeks (P < .02). Reduced levels of alanine transaminase (ALT) were also seen in the group consuming ACE (P < .08). Previous studies showed reduction of chronic pain when consuming 1 g ACE per day. The higher dose of 2.3 g/day in this study was associated with significant reduction of chronic pain at rest and when physically active (P < .05). Consumption of ACE showed safety regarding markers pertaining to anticoagulant activity and platelet activation status, in conjunction with rapid and robust relief of chronic pain. Reduction in AST and ALT suggested improvement in liver function and metabolism. PMID:27362442

  4. Clinical Safety of a High Dose of Phycocyanin-Enriched Aqueous Extract from Arthrospira (Spirulina) platensis: Results from a Randomized, Double-Blind, Placebo-Controlled Study with a Focus on Anticoagulant Activity and Platelet Activation.

    PubMed

    Jensen, Gitte S; Drapeau, Cassandra; Lenninger, Miki; Benson, Kathleen F

    2016-07-01

    The goal for this study was to evaluate safety regarding anticoagulant activity and platelet activation during daily consumption of an aqueous cyanophyta extract (ACE), containing a high dose of phycocyanin. Using a randomized, double-blind, placebo-controlled study design, 24 men and women were enrolled after informed consent, and consumed either ACE (2.3 g/day) or placebo daily for 2 weeks. The ACE dose was equivalent to ∼1 g phycocyanin per day, chosen based on the highest dose Generally Recognized as Safe (GRAS) by the U.S. Food and Drug Administration. Consuming ACE did not alter markers for platelet activation (P-selectin expression) or serum P-selectin levels. No changes were seen for activated partial thromboplastin time, thrombin clotting time, or fibrinogen activity. Serum levels of aspartate transaminase (AST) showed a significant reduction after 2 weeks of ACE consumption (P < .001), in contrast to placebo where no changes were seen; the difference in AST levels between the two groups was significant at 2 weeks (P < .02). Reduced levels of alanine transaminase (ALT) were also seen in the group consuming ACE (P < .08). Previous studies showed reduction of chronic pain when consuming 1 g ACE per day. The higher dose of 2.3 g/day in this study was associated with significant reduction of chronic pain at rest and when physically active (P < .05). Consumption of ACE showed safety regarding markers pertaining to anticoagulant activity and platelet activation status, in conjunction with rapid and robust relief of chronic pain. Reduction in AST and ALT suggested improvement in liver function and metabolism. PMID:27362442

  5. MEMS Sensor Technologies for Human Centred Applications in Healthcare, Physical Activities, Safety and Environmental Sensing: A Review on Research Activities in Italy

    PubMed Central

    Ciuti, Gastone; Ricotti, Leonardo; Menciassi, Arianna; Dario, Paolo

    2015-01-01

    Over the past few decades the increased level of public awareness concerning healthcare, physical activities, safety and environmental sensing has created an emerging need for smart sensor technologies and monitoring devices able to sense, classify, and provide feedbacks to users’ health status and physical activities, as well as to evaluate environmental and safety conditions in a pervasive, accurate and reliable fashion. Monitoring and precisely quantifying users’ physical activity with inertial measurement unit-based devices, for instance, has also proven to be important in health management of patients affected by chronic diseases, e.g., Parkinson’s disease, many of which are becoming highly prevalent in Italy and in the Western world. This review paper will focus on MEMS sensor technologies developed in Italy in the last three years describing research achievements for healthcare and physical activity, safety and environmental sensing, in addition to smart systems integration. Innovative and smart integrated solutions for sensing devices, pursued and implemented in Italian research centres, will be highlighted, together with specific applications of such technologies. Finally, the paper will depict the future perspective of sensor technologies and corresponding exploitation opportunities, again with a specific focus on Italy. PMID:25808763

  6. General active space commutator-based coupled cluster theory of general excitation rank for electronically excited states: Implementation and application to ScH

    NASA Astrophysics Data System (ADS)

    Hubert, Mickaël; Olsen, Jeppe; Loras, Jessica; Fleig, Timo

    2013-11-01

    We present a new implementation of general excitation rank coupled cluster theory for electronically excited states based on the single-reference multi-reference formalism. The method may include active-space selected and/or general higher excitations by means of the general active space concept. It may employ molecular integrals over the four-component Lévy-Leblond Hamiltonian or the relativistic spin-orbit-free four-component Hamiltonian of Dyall. In an initial application to ground- and excited states of the scandium monohydride molecule we report spectroscopic constants using basis sets of up to quadruple-zeta quality and up to full iterative triple excitations in the cluster operators. Effects due to spin-orbit interaction are evaluated using two-component multi-reference configuration interaction for assessing the accuracy of the coupled cluster results.

  7. General active space commutator-based coupled cluster theory of general excitation rank for electronically excited states: Implementation and application to ScH

    SciTech Connect

    Hubert, Mickaël; Loras, Jessica; Fleig, Timo; Olsen, Jeppe

    2013-11-21

    We present a new implementation of general excitation rank coupled cluster theory for electronically excited states based on the single-reference multi-reference formalism. The method may include active-space selected and/or general higher excitations by means of the general active space concept. It may employ molecular integrals over the four-component Lévy-Leblond Hamiltonian or the relativistic spin-orbit-free four-component Hamiltonian of Dyall. In an initial application to ground- and excited states of the scandium monohydride molecule we report spectroscopic constants using basis sets of up to quadruple-zeta quality and up to full iterative triple excitations in the cluster operators. Effects due to spin-orbit interaction are evaluated using two-component multi-reference configuration interaction for assessing the accuracy of the coupled cluster results.

  8. Quality and safety issues highlighted by patients in the handling of laboratory test results by general practices–a qualitative study

    PubMed Central

    2014-01-01

    Background In general practice internationally, many care teams handle large numbers of laboratory test results relating to patients in their care. Related research about safety issues is limited with most of the focus on this workload from secondary care and in North American settings. Little has been published in relation to primary health care in the UK and wider Europe. This study aimed to explore experiences and perceptions of patients with regards to the handling of test results by general practices. Methods A qualitative research approach was used with patients. The setting was west of Scotland general practices from one National Health Service territorial board area. Patients were purposively sampled from practice held lists of patients who received a number of laboratory tests because of chronic medical problems or surveillance of high risk medicines. Focus groups were held and were audio-recorded. Tapes were transcribed and subjected to qualitative analysis. Transcripts were coded and codes merged into themes by two of the researchers. Results 19 participants from four medical practices took part in four focus groups. The main themes identified were: 1. Patients lacked awareness of the results handling process in their practice. 2. Patients usually did not contact their practice for test results, unless they considered themselves to be ill. 3. Patients were concerned about the appropriateness of administrators being involved in results handling. 4. Patients were concerned about breaches of confidentiality when administrators were involved in results handling. 5. Patients valued the use of dedicated results handling staff. 6. Patients welcomed the use of technology to alert them to results being available, and valued the ability to choose how this happened. Conclusions The study confirms the quality and safety of care problems associated with results handling systems and adds to our knowledge of the issues that impact in these areas. Practices need to be

  9. The OECD Blue Book on Recombinant DNA Safety Considerations: it's influence on ISBR and EFSA activities.

    PubMed

    Schiemann, Joachim

    2006-01-01

    Biosafety regulatory frameworks are intended to serve as mechanisms for ensuring the safe use of biotechnology products without imposing unacceptable risk to human health or the environment, or unintended constraints to technology transfer. The OECD Blue Book on "Recombinant DNA Safety Considerations", setting out principles and concepts for handling genetically modified organisms safely outside of contained laboratory conditions, was a milestone in the history of biotechnology. The "Recombinant DNA Safety Considerations" definitively became the major resource for the formulation of national regulatory frameworks and international regulations, including the Cartagena Protocol. PMID:17640515

  10. Increased diagnostic activity in general practice during the year preceding colorectal cancer diagnosis.

    PubMed

    Hansen, Pernille Libach; Hjertholm, Peter; Vedsted, Peter

    2015-08-01

    Accurate diagnostic activity in general practice before colorectal cancer (CRC) diagnosis is crucial for an early detection of CRC. This study aimed to investigate the rates of daytime consultations, hemoglobin (Hb) measurements and medicine prescriptions for hemorrhoids in general practice in the year preceding CRC diagnosis. Using Danish registries, we conducted a population-based matched cohort study including CRC patients aged 40-80 years (n = 19,209) and matched references (n = 192,090). We calculated odds ratios (ORs) using a conditional logistical regression model and incidence rate ratios (IRRs) using a negative binomial regression model. The CRC patients had significantly more consultations from 9 months before diagnosis and significantly increased rates of Hb measurements from up to 17 months before diagnosis compared with references. Furthermore, up to 18 months before diagnosis, CRC patients had significantly higher rates of prescriptions for hemorrhoids; and 2 months before diagnosis, the IRR was 12.24 (95% confidence interval (CI): 10.29-14.55) for men. The positive predictive value (PPV) of CRC for having a first-time prescription for hemorrhoids was highest among men aged 70-80 years [PPV = 3.2% (95% CI: 2.8-3.7)]. High prescription rates were predominantly seen among rectal cancer patients, whereas colon cancer patients had higher rates of consultations and Hb measurements. This study revealed a significant increase in healthcare seeking and diagnostic activity in general practice in the year prior to CRC diagnosis, which indicates the presence of a "diagnostic time window" and a potential for earlier diagnosis of CRC based on clinical signs and symptoms. PMID:25559926

  11. Accounting for medical variation: the case of prescribing activity in a New Zealand general practice sample.

    PubMed

    Davis, P B; Yee, R L; Millar, J

    1994-08-01

    Medical practice variation is extensive and well documented, particularly for surgical interventions, and raises important questions for health policy. To date, however, little work has been carried out on interpractitioner variation in prescribing activity in the primary care setting. An analytical model of medical variation is derived from the literature and relevant indicators are identified from a study of New Zealand general practice. The data are based on nearly 9,500 completed patient encounter records drawn from over a hundred practitioners in the Waikato region of the North Island, New Zealand. The data set represents a 1% sample of all weekday general practice office encounters in the Hamilton Health District recorded over a 12-month period. Overall levels of prescribing, and the distribution of drug mentions across diagnostic groupings, are broadly comparable to results drawn from international benchmark data. A multivariate analysis is carried out on seven measures of activity in the areas of prescribing volume, script detail, and therapeutic choice. The analysis indicates that patient, practitioner and practice attributes exert little systematic influence on the prescribing task. The principal influences are diagnosis, followed by practitioner identity. The pattern of findings suggests also that the prescribing task cannot be viewed as an undifferentiated activity. It is more usefully considered as a process of decision-making in which 'core' judgements--such as the decision to prescribe and the choice of drug--are highly predictable and strongly influenced by diagnosis, while 'peripheral' features of the task--such as choosing a combination drug or prescribing generically--are less determinate and more subject to the exercise of clinical discretion.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7939853

  12. 78 FR 64538 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Safety...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-29

    ... notice published in the Federal Register on June 14, 2013 (78 FR 35975). Interested parties are...; Safety Standards for Underground Coal Mine Ventilation--Belt Entry Used as an Intake Air Course To... Mine Ventilation--Belt Entry Used as an Intake Air Course to Ventilate Working Sections and Areas...

  13. 78 FR 48890 - Information Collection Activities: Safety and Environmental Management Systems (SEMS); Proposed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-12

    ...To comply with the Paperwork Reduction Act of 1995 (PRA), Bureau of Safety and Environmental Enforcement (BSEE) is inviting comments on a collection of information that we will resubmit to the Office of Management and Budget (OMB) for review and approval. The resubmission of this information collection request (ICR) is necessary to include a form that we developed to clarify and facilitate......

  14. 77 FR 28602 - Agency Information Collection Activities; Proposed Collection; Comment Request; Early Food Safety...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-15

    ... (57 FR 22984). The guidance entitled, ``Recommendations for the Early Food Safety Evaluation of New... submitter has determined that all files provided in an electronic transmission are free of computer viruses... variety is a one- time burden (one evaluation per new protein). Based on its experience over the past...

  15. Instructional Resources Monograph Series: Safety in Wastewater Treatment Systems. Selected Instructional Activities and References.

    ERIC Educational Resources Information Center

    Coon, Herbert L.

    Described are instructional and reference materials that may be useful to managers, supervisors, foremen and others who are interested in the safety education of workers in wastewater systems. Emphasis is upon items relevant to the development and presentation of wastewater treatment training programs. Part I contains descriptions and excerpts…

  16. 78 FR 41829 - Pipeline Safety: Information Collection Activities, Revision to Annual Report for Hazardous...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-11

    ... the information collection was published on February 6, 2013, (78 FR 8699). PHMSA received one comment..., Revision to Annual Report for Hazardous Liquid Pipeline Systems AGENCY: Pipeline and Hazardous Materials... from hazardous liquid operators' annual reports is an important tool for identifying safety trends...

  17. Effect of dexamethasone on bactericidal activity of turkey monocytes and implications for food safety

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Stress has been shown to affect the immune system of turkeys making them more susceptible to bacterial infections that may compromise food safety. Female turkeys are more resistant to stress-induced opportunistic bacterial infections than are male turkeys. In order to determine the mechanism of this...

  18. 76 FR 8401 - Pipeline Safety: Agency Information Collection Activities: Notice of Request for Extension of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-14

    ... and Hazardous Materials Safety Administration (PHMSA), U.S. Department of Transportation (DOT...-mail at angela.dow@dot.gov , or by mail at U.S. Department of Transportation, Pipeline and Hazardous... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF...

  19. Efficacy and safety of ramosetron versus ondansetron for postoperative nausea and vomiting after general anesthesia: a meta-analysis of randomized clinical trials

    PubMed Central

    Gao, Chengjie; Li, Bo; Xu, Lufeng; Lv, Fubin; Cao, Guimao; Wang, Huixia; Wang, Fei; Wu, Guanghan

    2015-01-01

    Background Postoperative nausea and vomiting is a common side effect of general anesthesia. In this study, we performed a meta-analysis on the efficacy and safety of ramosetron versus ondansetron in the prevention of postoperative nausea and vomiting using the most recently published randomized controlled clinical studies. Methods PubMed and EMBASE were searched for randomized controlled clinical trials comparing the efficacy and safety of ramosetron and ondansetron. The meta-analysis was performed using Review Manager version 5.3 (Cochrane Collaboration, Oxford, UK). Dichotomous outcomes are presented as the relative risk (RR) with a 95% confidence interval (CI). Results A total of 898 patients from nine selected studies were treated with antiemetics after surgery, including 450 patients who received ondansetron 4 mg and 448 patients who received ramosetron 0.3 mg. The meta-analysis showed no statistically significant difference between the two groups with regard to prevention of postoperative nausea (PON) during different time periods in the 48 hours after surgery. When comparing the efficacy of ramosetron and ondansetron in the prevention of postoperative vomiting (POV), at various time intervals in the 24 hours after surgery, ramosetron was significantly more efficient than ondansetron: 0–6 hours (RR 0.46, 95% CI 0.24–0.92; P=0.03), 0–24 hours (RR 0.72, 95% CI 0.52–1.00; P=0.05), and 6–24 hours (RR 0.51, 95% CI 0.31–0.84; P=0.008). At other time periods between 24 and 48 hours after surgery, ramosetron did not show better efficacy than ondansetron. When comparing the safety profiles of ramosetron and ondansetron, fewer side effects were recorded in the ramosetron group (RR 0.65, 95% CI 0.47–0.91; P=0.01). Conclusion Our meta-analysis demonstrates that ramosetron was more effective than ondansetron in the prevention of early POV (0–24 hours) with fewer recorded side effects. However, our study did not reveal any statistically significant

  20. Combination therapy of orally administered glycyrrhizin and UVB improved active-stage generalized vitiligo

    PubMed Central

    Mou, K.H.; Han, D.; Liu, W.L.; Li, P.

    2016-01-01

    Glycyrrhizin has been used clinically for several years due to its beneficial effect on immunoglobulin E (IgE)-induced allergic diseases, alopecia areata and psoriasis. In this study, glycyrrhizin, ultraviolet B light (UVB) or a combination of both were used to treat active-stage generalized vitiligo. One hundred and forty-four patients between the ages of 3 and 48 years were divided into three groups: group A received oral compound glycyrrhizin (OCG); group B received UVB applications twice weekly, and group C received OCG+UVB. Follow-ups were performed at 2, 4, and 6 months after the treatment was initiated. The Vitiligo Area Scoring Index (VASI) and the Vitiligo Disease Activity (VIDA) instrument were used to assess the affected body surface, at each follow-up. Results showed that 77.1, 75.0 and 87.5% in groups A, B and C, respectively, presented repigmentation of lesions. Responsiveness to therapy seemed to be associated with lesion location and patient compliance. Adverse events were limited and transient. This study showed that, although the three treatment protocols had positive results, OCG and UVB combination therapy was the most effective and led to improvement in disease stage from active to stable. PMID:27464024

  1. Combination therapy of orally administered glycyrrhizin and UVB improved active-stage generalized vitiligo.

    PubMed

    Mou, K H; Han, D; Liu, W L; Li, P

    2016-07-25

    Glycyrrhizin has been used clinically for several years due to its beneficial effect on immunoglobulin E (IgE)-induced allergic diseases, alopecia areata and psoriasis. In this study, glycyrrhizin, ultraviolet B light (UVB) or a combination of both were used to treat active-stage generalized vitiligo. One hundred and forty-four patients between the ages of 3 and 48 years were divided into three groups: group A received oral compound glycyrrhizin (OCG); group B received UVB applications twice weekly, and group C received OCG+UVB. Follow-ups were performed at 2, 4, and 6 months after the treatment was initiated. The Vitiligo Area Scoring Index (VASI) and the Vitiligo Disease Activity (VIDA) instrument were used to assess the affected body surface, at each follow-up. Results showed that 77.1, 75.0 and 87.5% in groups A, B and C, respectively, presented repigmentation of lesions. Responsiveness to therapy seemed to be associated with lesion location and patient compliance. Adverse events were limited and transient. This study showed that, although the three treatment protocols had positive results, OCG and UVB combination therapy was the most effective and led to improvement in disease stage from active to stable. PMID:27464024

  2. A Vehicle Active Safety Model: Vehicle Speed Control Based on Driver Vigilance Detection Using Wearable EEG and Sparse Representation.

    PubMed

    Zhang, Zutao; Luo, Dianyuan; Rasim, Yagubov; Li, Yanjun; Meng, Guanjun; Xu, Jian; Wang, Chunbai

    2016-01-01

    In this paper, we present a vehicle active safety model for vehicle speed control based on driver vigilance detection using low-cost, comfortable, wearable electroencephalographic (EEG) sensors and sparse representation. The proposed system consists of three main steps, namely wireless wearable EEG collection, driver vigilance detection, and vehicle speed control strategy. First of all, a homemade low-cost comfortable wearable brain-computer interface (BCI) system with eight channels is designed for collecting the driver's EEG signal. Second, wavelet de-noising and down-sample algorithms are utilized to enhance the quality of EEG data, and Fast Fourier Transformation (FFT) is adopted to extract the EEG power spectrum density (PSD). In this step, sparse representation classification combined with k-singular value decomposition (KSVD) is firstly introduced in PSD to estimate the driver's vigilance level. Finally, a novel safety strategy of vehicle speed control, which controls the electronic throttle opening and automatic braking after driver fatigue detection using the above method, is presented to avoid serious collisions and traffic accidents. The simulation and practical testing results demonstrate the feasibility of the vehicle active safety model. PMID:26907278

  3. A Vehicle Active Safety Model: Vehicle Speed Control Based on Driver Vigilance Detection Using Wearable EEG and Sparse Representation

    PubMed Central

    Zhang, Zutao; Luo, Dianyuan; Rasim, Yagubov; Li, Yanjun; Meng, Guanjun; Xu, Jian; Wang, Chunbai

    2016-01-01

    In this paper, we present a vehicle active safety model for vehicle speed control based on driver vigilance detection using low-cost, comfortable, wearable electroencephalographic (EEG) sensors and sparse representation. The proposed system consists of three main steps, namely wireless wearable EEG collection, driver vigilance detection, and vehicle speed control strategy. First of all, a homemade low-cost comfortable wearable brain-computer interface (BCI) system with eight channels is designed for collecting the driver’s EEG signal. Second, wavelet de-noising and down-sample algorithms are utilized to enhance the quality of EEG data, and Fast Fourier Transformation (FFT) is adopted to extract the EEG power spectrum density (PSD). In this step, sparse representation classification combined with k-singular value decomposition (KSVD) is firstly introduced in PSD to estimate the driver’s vigilance level . Finally, a novel safety strategy of vehicle speed control, which controls the electronic throttle opening and automatic braking after driver fatigue detection using the above method, is presented to avoid serious collisions and traffic accidents. The simulation and practical testing results demonstrate the feasibility of the vehicle active safety model. PMID:26907278

  4. A hardware-based computational platform for Generalized Laguerre-Volterra MIMO model for neural activities.

    PubMed

    Li, Will X Y; Chan, Rosa H M; Zhang, Wei; Cheung, Ray C C; Song, Dong; Berger, Theodore W

    2011-01-01

    A parallelized and pipelined architecture based on FPGA and a higher-level Self Reconfiguration Platform are proposed in this paper to model Generalized Laguerre-Volterra MIMO system essential in identifying the time-varying neural dynamics underlying spike activities. Our proposed design is based on the Xilinx Virtex-6 FPGA platform and the processing core can produce data samples at a speed of 1.33 × 10(6)/s, which is 3.1 × 10(3) times faster than the corresponding C model running on an Intel i7-860 Quad Core Processor. The ongoing work of the construction of the advanced Self Reconfiguration Platform is presented and initial test results are provided. PMID:22256020

  5. Triangular Relationship between Sleep Spindle Activity, General Cognitive Ability and the Efficiency of Declarative Learning

    PubMed Central

    Dürr, Roland; Achermann, Peter; Huber, Reto

    2012-01-01

    EEG sleep spindle activity (SpA) during non-rapid eye movement (NREM) sleep has been reported to be associated with measures of intelligence and overnight performance improvements. The reticular nucleus of the thalamus is generating sleep spindles in interaction with thalamocortical connections. The same system enables efficient encoding and processing during wakefulness. Thus, we examined if the triangular relationship between SpA, measures of intelligence and declarative learning reflect the efficiency of the thalamocortical system. As expected, SpA was associated with general cognitive ability, e.g. information processing speed. SpA was also associated with learning efficiency, however, not with overnight performance improvement in a declarative memory task. SpA might therefore reflect the efficiency of the thalamocortical network and can be seen as a marker for learning during encoding in wakefulness, i.e. learning efficiency. PMID:23185361

  6. Generalized Investigation of the Rotation-Activity Relation: Favoring Rotation Period instead of Rossby Number

    NASA Astrophysics Data System (ADS)

    Reiners, A.; Schüssler, M.; Passegger, V. M.

    2014-10-01

    Magnetic activity in Sun-like and low-mass stars causes X-ray coronal emission which is stronger for more rapidly rotating stars. This relation is often interpreted in terms of the Rossby number, i.e., the ratio of rotation period to convective overturn time. We reconsider this interpretation on the basis of the observed X-ray emission and rotation periods of 821 stars with masses below 1.4 M ⊙. A generalized analysis of the relation between X-ray luminosity normalized by bolometric luminosity, L X/L bol, and combinations of rotational period, P, and stellar radius, R, shows that the Rossby formulation does not provide the solution with minimal scatter. Instead, we find that the relation L X/L bolvpropP -2 R -4 optimally describes the non-saturated fraction of the stars. This relation is equivalent to L XvpropP -2, indicating that the rotation period alone determines the total X-ray emission. Since L X is directly related to the magnetic flux at the stellar surface, this means that the surface flux is determined solely by the star's rotation and is independent of other stellar parameters. While a formulation in terms of a Rossby number would be consistent with these results if the convective overturn time scales exactly as L_bol-1/2, our generalized approach emphasizes the need to test a broader range of mechanisms for dynamo action in cool stars.

  7. Generalized Hammersley Process and Phase Transition for Activated Random Walk Models

    NASA Astrophysics Data System (ADS)

    Rolla, Leonardo T.

    2008-12-01

    * ACTIVATED RANDOM WALK MODEL * This is a conservative particle system on the lattice, with a Markovian continuous-time evolution. Active particles perform random walks without interaction, and they may as well change their state to passive, then stopping to jump. When particles of both types occupy the same site, they all become active. This model exhibits phase transition in the sense that for low initial densities the system locally fixates and for high densities it keeps active. Though extensively studied in the physics literature, the matter of giving a mathematical proof of such phase transition remained as an open problem for several years. In this work we identify some variables that are sufficient to characterize fixation and at the same time are stochastically monotone in the model's parameters. We employ an explicit graphical representation in order to obtain the monotonicity. With this method we prove that there is a unique phase transition for the one-dimensional finite-range random walk. Joint with V. Sidoravicius. * BROKEN LINE PROCESS * We introduce the broken line process and derive some of its properties. Its discrete version is presented first and a natural generalization to the continuum is then proposed and studied. The broken lines are related to the Young diagram and the Hammersley process and are useful for computing last passage percolation values and finding maximal oriented paths. For a class of passage time distributions there is a family of boundary conditions that make the process stationary and reversible. One application is a simple proof of the explicit law of large numbers for last passage percolation with exponential and geometric distributions. Joint with V. Sidoravicius, D. Surgailis, and M. E. Vares.

  8. A General Methodology for Evaluation of Carbon Sequestration Activities and Carbon Credits

    SciTech Connect

    Klasson, KT

    2002-12-23

    A general methodology was developed for evaluation of carbon sequestration technologies. In this document, we provide a method that is quantitative, but is structured to give qualitative comparisons despite changes in detailed method parameters, i.e., it does not matter what ''grade'' a sequestration technology gets but a ''better'' technology should receive a better grade. To meet these objectives, we developed and elaborate on the following concepts: (1) All resources used in a sequestration activity should be reviewed by estimating the amount of greenhouse gas emissions for which they historically are responsible. We have done this by introducing a quantifier we term Full-Cycle Carbon Emissions, which is tied to the resource. (2) The future fate of sequestered carbon should be included in technology evaluations. We have addressed this by introducing a variable called Time-adjusted Value of Carbon Sequestration to weigh potential future releases of carbon, escaping the sequestered form. (3) The Figure of Merit of a sequestration technology should address the entire life-cycle of an activity. The figures of merit we have developed relate the investment made (carbon release during the construction phase) to the life-time sequestration capacity of the activity. To account for carbon flows that occur during different times of an activity we incorporate the Time Value of Carbon Flows. The methodology we have developed can be expanded to include financial, social, and long-term environmental aspects of a sequestration technology implementation. It does not rely on global atmospheric modeling efforts but is consistent with these efforts and could be combined with them.

  9. Launch Services Safety Overview

    NASA Technical Reports Server (NTRS)

    Loftin, Charles E.

    2008-01-01

    NASA/KSC Launch Services Division Safety (SA-D) services include: (1) Assessing the safety of the launch vehicle (2) Assessing the safety of NASA ELV spacecraft (S/C) / launch vehicle (LV) interfaces (3) Assessing the safety of spacecraft processing to ensure resource protection of: - KSC facilities - KSC VAFB facilities - KSC controlled property - Other NASA assets (4) NASA personnel safety (5) Interfacing with payload organizations to review spacecraft for adequate safety implementation and compliance for integrated activities (6) Assisting in the integration of safety activities between the payload, launch vehicle, and processing facilities

  10. Application of viability theory for road vehicle active safety during cornering manoeuvres

    NASA Astrophysics Data System (ADS)

    Vandanjon, P.-O.; Coiret, A.; Lorino, T.

    2014-02-01

    Viability theory proposes geometric metaphors in addition to classical ordinary differential equation analysis. In this paper, advantages of applying viability theory to road safety domain are presented. The exact issue is to determine if, from an initial state of a vehicle/road/driver system, a soft controls strategy is compatible with a safe driving sequence. The case of a car negotiating a curve is considered. The application of the viability theory to this issue offers the advantage to avoid classical full computing of the system. Instead of that, it consists on verifying that the states and the controls belong to a subset called the viability kernel. The construction and the use of the viability kernel for a vehicle system dynamic is proposed by using support vector machines algorithm. Then, the applicability of this theory is demonstrated through experimental tests. This innovative application of the viability theory to vehicle dynamics with road safety concerns could benefit to robust embedded warning systems.

  11. Highway Safety Program Manual: Volume 3: Motorcycle Safety.

    ERIC Educational Resources Information Center

    National Highway Traffic Safety Administration (DOT), Washington, DC.

    Volume 3 of the 19-volume Highway Safety Program Manual (which provides guidance to State and local governments on preferred highway safety practices) concentrates on aspects of motorcycle safety. The purpose and specific objectives of a State motorcycle safety program are outlined. Federal authority in the highway safety area and general policies…

  12. Are safety-related features of the road environment associated with smaller declines in physical activity among youth?

    PubMed

    Carver, Alison; Timperio, Anna; Hesketh, Kylie; Crawford, David

    2010-01-01

    This study examined how objective measures of the local road environment related to safety were associated with change in physical activity (including active transport) among youth. Few longitudinal studies have examined the impact of the road environment on physical activity among children/adolescents in their neighborhoods. Participants were children aged 8-9 years (n = 170) and adolescents aged 13-15 years (n = 276) in 2004. Data were collected in 2004 and 2006 during follow-up of participants recruited initially in 2001 from 19 primary schools in Melbourne, Australia. Walking/cycling to local destinations was parent-reported for children and self-reported by adolescents. Moderate-to-vigorous physical activity (MVPA) during nonschool hours was recorded using accelerometers. Road environment features in each participant's neighborhood (area within 800 m radius of their home) were measured objectively using a Geographical Information System. Linear regression analyses examined associations between road features and changes in active transport (AT) and MVPA over 2 years. Children's AT increased but MVPA levels decreased in both age groups; on average, younger girls recorded the greatest declines. The number of traffic/pedestrian lights was associated with DeltaAT among younger girls (B=0.45, p=0.004). The total length of walking tracks (in meters) was associated with AT among younger girls (B = 0.0016, p = 0.015) and adolescent girls (B = 0.0016, p = 0.002). For adolescent boys, intersection density was associated with AT (B = 0.03, p = 0.030). Slow points were associated with MVPA among younger boys before school (B = 1.55, p = 0.021), while speed humps were associated with MVPA among adolescent boys after school (B = 0.23, p = 0.015). There were many associations for adolescent girls: for example, the total length of local roads (B = 0.49, p = 0.005), intersection density (B = 0.05, p = 0.036), and number of speed humps (B = 0.33, p = 0.020) were associated with

  13. Exploratory Studies in Generalized Predictive Control for Active Aeroelastic Control of Tiltrotor Aircraft

    NASA Technical Reports Server (NTRS)

    Kvaternik, Raymond G.; Juang, Jer-Nan; Bennett, Richard L.

    2000-01-01

    The Aeroelasticity Branch at NASA Langley Research Center has a long and substantive history of tiltrotor aeroelastic research. That research has included a broad range of experimental investigations in the Langley Transonic Dynamics Tunnel (TDT) using a variety of scale models and the development of essential analyses. Since 1994, the tiltrotor research program has been using a 1/5-scale, semispan aeroelastic model of the V-22 designed and built by Bell Helicopter Textron Inc. (BHTI) in 1981. That model has been refurbished to form a tiltrotor research testbed called the Wing and Rotor Aeroelastic Test System (WRATS) for use in the TDT. In collaboration with BHTI, studies under the current tiltrotor research program are focused on aeroelastic technology areas having the potential for enhancing the commercial and military viability of tiltrotor aircraft. Among the areas being addressed, considerable emphasis is being directed to the evaluation of modern adaptive multi-input multi- output (MIMO) control techniques for active stability augmentation and vibration control of tiltrotor aircraft. As part of this investigation, a predictive control technique known as Generalized Predictive Control (GPC) is being studied to assess its potential for actively controlling the swashplate of tiltrotor aircraft to enhance aeroelastic stability in both helicopter and airplane modes of flight. This paper summarizes the exploratory numerical and experimental studies that were conducted as part of that investigation.

  14. Super Safety and Health Day at KSC

    NASA Technical Reports Server (NTRS)

    2000-01-01

    In the Training Auditorium at KSC, Brig. General Donald P. Pettit, commander of the 45th Space Wing, speaks to attendees at a presentation for Super Safety and Health Day. Safety Day is a full day of NASA-sponsored, KSC and 45th Space Wing events involving a number of health and safety related activities: Displays, vendors, technical paper sessions, panel discussions, a keynote speaker, etc. The entire Center and Wing stand down to participate in the planned events. Safety Day is held annually to proactively increase awareness in safety and health among the government and contractor workforce population. The first guiding principle at KSC is '''Safety and Health First.''' KSC's number one goal is to '''Assure sound, safe and efficient practices and processes are in place for privatized/commercialized launch site processing.'''

  15. Control of spending on nuclear safety

    SciTech Connect

    Siddall, E.

    1980-07-01

    Nuclear safety is reviewed in relation to safety in the community as a whole. A method is proposed which points to an optimum expenditure on nuclear safety measures as opposed to the present open-ended situation. At this optimum point the cost of saving extra lives in the nuclear field is equal to the cost of saving extra lives in other activities in the community. The method requires that the present level of safety be estimated, and this is done by relating the work of Rasmussen, Farmer and Beattie; and the recent German study to the actual record of accidents. The analysis indicates that present expenditures on reactor safety are far in excess of the optimum. An even more striking conclusion is reached when the possible effect of the wealth-generated by the nuclear industry on the general safety of the community is considered. The application of the theme to the Pickering Nuclear Generating Station is developed.

  16. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis.

    PubMed

    Chandran, Binu; Goel, Ajay

    2012-11-01

    Curcumin is known to possess potent antiinflammatory and antiarthritic properties. This pilot clinical study evaluated the safety and effectiveness of curcumin alone, and in combination with diclofenac sodium in patients with active rheumatoid arthritis (RA). Forty-five patients diagnosed with RA were randomized into three groups with patients receiving curcumin (500 mg) and diclofenac sodium (50 mg) alone or their combination. The primary endpoints were reduction in Disease Activity Score (DAS) 28. The secondary endpoints included American College of Rheumatology (ACR) criteria for reduction in tenderness and swelling of joint scores. Patients in all three treatment groups showed statistically significant changes in their DAS scores. Interestingly, the curcumin group showed the highest percentage of improvement in overall DAS and ACR scores (ACR 20, 50 and 70) and these scores were significantly better than the patients in the diclofenac sodium group. More importantly, curcumin treatment was found to be safe and did not relate with any adverse events. Our study provides the first evidence for the safety and superiority of curcumin treatment in patients with active RA, and highlights the need for future large-scale trials to validate these findings in patients with RA and other arthritic conditions. PMID:22407780

  17. Participating in politics resembles physical activity: general action patterns in international archives, United States archives, and experiments.

    PubMed

    Noguchi, Kenji; Handley, Ian M; Albarracín, Dolores

    2011-02-01

    A series of studies examined whether political participation can emerge from general patterns of indiscriminate activity. In the first two studies, general action tendencies were measured by combining national and state-level indicators of high activity (e.g., impulsiveness, pace of life, and physical activity) from international and U.S. data. This action-tendency index positively correlated with a measure of political participation that consisted of voting behaviors and participation in political demonstrations. The following two experimental studies indicated that participants exposed to action words (e.g., go, move) had stronger intentions to vote in an upcoming election and volunteered more time to make phone calls on behalf of a university policy than participants exposed to inaction words did (e.g., relax, stop). These studies suggest that political participation can be predicted from general tendencies toward activity present at the national and state levels, as well as from verbal prompts suggestive of activity. PMID:21177515

  18. Participating in Politics Resembles Physical Activity: General Action Patterns in International Archives, United States Archives, and Experiments

    PubMed Central

    Noguchi, Kenji; Handley, Ian M.; Albarracín, Dolores

    2016-01-01

    A series of studies examined whether political participation can emerge from general patterns of indiscriminate activity. In the first two studies, general action tendencies were measured by combining national and state-level indicators of high activity (e.g., impulsiveness, pace of life, and physical activity) from international and U.S. data. This action-tendency index positively correlated with a measure of political participation that consisted of voting behaviors and participation in political demonstrations. The following two experimental studies indicated that participants exposed to action words (e.g., go, move) had stronger intentions to vote in an upcoming election and volunteered more time to make phone calls on behalf of a university policy than participants exposed to inaction words did (e.g., relax, stop). These studies suggest that political participation can be predicted from general tendencies toward activity present at the national and state levels, as well as from verbal prompts suggestive of activity. PMID:21177515

  19. Vocational Safety Guide to Generalized Safety Provisions as They Apply to: Agricultural Education, Business and Office Education, Health Occupations Education, Home Economics Education, Industrial Arts Education, Marketing and Distributive Education, Trade and Technical Education.

    ERIC Educational Resources Information Center

    Dyrenfurth, Michael J.; Linhardt, Richard E.

    This vocational safety guide is designed to help Missouri school practitioners at all levels in providing for the safe instruction and work associated with practical arts and vocational and technical subjects. Covered in the individual sections of the guide are the following topics: Missouri legislation and regulations pertaining to school safety;…

  20. Student research activities in the Technology Assessments Section of the Health and Safety Research Division, Summer 1980

    SciTech Connect

    Chester, R.O.; Roberts, D.A.

    1981-08-01

    Reports summarizing activities of students assigned to the Technology Assessments Section of the Health and Safety Research Division for the summer 1980 are presented. Unless indicated otherwise, each report was written by the student whose work is being described. For each student, the student's supervisor, the name of the program under which the student was brought to ORNL, the academic level of the student, and the name of the ORNL project to which the student was assigned are tabulated. The reports are presented in alphabetical order of the students' last names.

  1. Generalized investigation of the rotation-activity relation: favoring rotation period instead of Rossby number

    SciTech Connect

    Reiners, A.; Passegger, V. M.; Schüssler, M.

    2014-10-20

    Magnetic activity in Sun-like and low-mass stars causes X-ray coronal emission which is stronger for more rapidly rotating stars. This relation is often interpreted in terms of the Rossby number, i.e., the ratio of rotation period to convective overturn time. We reconsider this interpretation on the basis of the observed X-ray emission and rotation periods of 821 stars with masses below 1.4 M {sub ☉}. A generalized analysis of the relation between X-ray luminosity normalized by bolometric luminosity, L {sub X}/L {sub bol}, and combinations of rotational period, P, and stellar radius, R, shows that the Rossby formulation does not provide the solution with minimal scatter. Instead, we find that the relation L {sub X}/L {sub bol}∝P {sup –2} R {sup –4} optimally describes the non-saturated fraction of the stars. This relation is equivalent to L {sub X}∝P {sup –2}, indicating that the rotation period alone determines the total X-ray emission. Since L {sub X} is directly related to the magnetic flux at the stellar surface, this means that the surface flux is determined solely by the star's rotation and is independent of other stellar parameters. While a formulation in terms of a Rossby number would be consistent with these results if the convective overturn time scales exactly as L{sub bol}{sup −1/2}, our generalized approach emphasizes the need to test a broader range of mechanisms for dynamo action in cool stars.

  2. Assessing General and Specific Attitudes in Human Learning Behavior: An Activity Perspective and a Multilevel Modeling Approach

    ERIC Educational Resources Information Center

    Sun, Jun; Willson, Victor L.

    2008-01-01

    This article proposes a multilevel modeling approach to study the general and specific attitudes formed in human learning behavior. Based on the premises of activity theory, it conceptualizes the unit of analysis for attitude measurement as a scalable and evolving activity system rather than a single action. Measurement issues related to this…

  3. Construction safety in DOE. Part 1, Students guide

    SciTech Connect

    Handwerk, E C

    1993-08-01

    This report is the first part of a compilation of safety standards for construction activities on DOE facilities. This report covers the following areas: general safety and health provisions; occupational health and environmental control/haz mat; personal protective equipment; fire protection and prevention; signs, signals, and barricades; materials handling, storage, use, and disposal; hand and power tools; welding and cutting; electrical; and scaffolding.

  4. Factors associated with the rejection of active euthanasia: a survey among the general public in Austria

    PubMed Central

    2013-01-01

    Background In recent decades, the general public has become increasingly receptive toward a legislation that allows active voluntary euthanasia (AVE). The purpose of this study was to survey the current attitude towards AVE within the Austrian population and to identify explanatory factors in the areas of socio-demographics, personal experiences with care, and ideological orientation. A further objective was to examine differences depending on the type of problem formulation (abstract vs. situational) for the purpose of measuring attitude. Methods A representative cross-sectional study was conducted across the Austrian population. Data were acquired from 1,000 individuals aged 16 years and over based on telephone interviews (CATI). For the purpose of measuring attitude toward AVE, two different problem formulations (abstract vs. situational) were juxtaposed. Results The abstract question about active voluntary euthanasia was answered negatively by 28.8%, while 71.2% opted in favour of AVE or were undecided. Regression analyses showed rejection of AVE was positively correlated with number of adults and children in the household, experience with care of seriously ill persons, a conservative worldview, and level of education. Mean or high family income was associated with lower levels of rejection. No independent correlations were found for variables such as sex, age, political orientation, self-rated health, and experiences with care of terminally ill patients. Correlation for the situational problem formulation was weaker and included fewer predictors than for the abstract question. Conclusions Our results suggest that factors relating to an individual’s interpersonal living situation and his/her cognitive convictions might be important determinants of the attitude toward AVE. If and to the extent that personal care experience plays a role, it is rather associated with rejection than with acceptance of AVE. PMID:23826902

  5. Phase 1 Randomized Trial of the Vaginal Safety and Acceptability of SPL7013 Gel (VivaGel®) in Sexually Active Young Women (MTN-004)

    PubMed Central

    MCGOWAN, Ian; GOMEZ, Kailazarid; BRUDER, Karen; FEBO, Irma; CHEN, Beatrice A; RICHARDSON, Barbra A; HUSNIK, Marla; LIVANT, Edward; PRICE, Clare; Jacobson, Cindy

    2011-01-01

    Objectives The study was designed to assess the safety, adherence, acceptability, and effect on vaginal microflora of 3% SPL7013 Gel (VivaGel®), a novel dendrimer topical microbicide that inhibits HIV, HSV-2 and HPV in vitro and in animal models. Design Phase 1, randomized, double-blind, placebo-controlled study in sexually active women. Methods Sixty-one sexually active women aged 18–24 years were recruited from three sites in the United States. Participants were randomized 1:1:1 to receive VivaGel, VivaGel placebo, or a hydroxyethylcellulose (HEC) placebo twice daily for 14 consecutive days. Safety endpoints included genitourinary and/or other adverse events (AE). Changes in vaginal flora were determined from Gram-stained vaginal smears and quantitative vaginal culture. Results No serious AEs or withdrawals due to AEs were reported. Genitourinary symptoms were reported as follows: VivaGel (n=17/22; 77.3%), VivaGel placebo (n=14/21; 66.7%) and HEC (n=8/18; 44.4%) (NS, p=0.1). The incidence of abnormal pelvic exam findings was similar across all gel arms of the study. Using pair-wise comparison, women in the VivaGel arm had a significantly higher incidence of related genitourinary AEs compared with women in the HEC gel arm (0.297 versus 0.111 per 100 person years, respectively; p=0.003). Exposure to VivaGel and VivaGel placebo resulted in minor shifts in the vaginal microflora but there was no overall impact on incidence of bacterial vaginosis as assessed by Nugent score. Conclusions VivaGel was generally well tolerated and comparable with the VivaGel placebo, although there was a higher incidence of low grade related genital AEs compared to the HEC placebo gel. PMID:21505316

  6. School Safety Audit Protocol.

    ERIC Educational Resources Information Center

    DeMary, Jo Lynne; Owens, Marsha; Ramnarain, A. K. Vijay

    The 1997 Virginia General Assembly passed legislation directing school boards to require all schools to conduct safety audits. This audit is designed to assess the safety conditions in each public school to: (1) identify and, if necessary, develop solutions for physical safety concerns, including building security issues; and (2) identify and…

  7. Revitalizing Nuclear Safety Research.

    ERIC Educational Resources Information Center

    National Academy of Sciences - National Research Council, Washington, DC.

    This report covers the general issues involved in nuclear safety research and points out the areas needing detailed consideration. Topics included are: (1) "Principles of Nuclear Safety Research" (examining who should fund, who should conduct, and who should set the agenda for nuclear safety research); (2) "Elements of a Future Agenda for Nuclear…

  8. Ethnic minority children’s active commuting to school and association with physical activity and pedestrian safety behaviors

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Children's active commuting to school, i.e. walking or cycling to school, was associated with greater moderate-to-vigorous physical activity, although studies among ethnic minorities are sparse. Among a low-income, ethnic minority sample of fourth grade students from eight public schools, we examine...

  9. Exploratory Studies in Generalized Predictive Control for Active Gust Load Alleviation

    NASA Technical Reports Server (NTRS)

    Kvaternik, Raymond G.; Eure, Kenneth W.; Juang, Jer-Nan

    2006-01-01

    The results of numerical simulations aimed at assessing the efficacy of Generalized Predictive Control (GPC) for active gust load alleviation using trailing- and leading-edge control surfaces are presented. The equations underlying the method are presented and discussed, including system identification, calculation of control law matrices, and calculation of commands applied to the control effectors. Both embedded and explicit feedforward paths for inclusion of disturbance effects are addressed. Results from two types of simulations are shown. The first used a 3-DOF math model of a mass-spring-dashpot system subject to user-defined external disturbances. The second used open-loop data from a wind-tunnel test in which a wing model was excited by sinusoidal vertical gusts; closed-loop behavior was simulated in post-test calculations. Results obtained from these simulations have been decidedly positive. In particular, results of closed-loop simulations for the wing model showed reductions in root moments by factors as high as 1000, depending on whether the excitation is from a constant- or variable-frequency gust and on the direction of the response.

  10. Measurement of General and Specific Approaches to Physical Activity Parenting: A Systematic Review

    PubMed Central

    McDonald, Samantha; Cohen, Alysia

    2013-01-01

    Abstract Background Parents play a significant role in shaping youth physical activity (PA). However, interventions targeting PA parenting have been ineffective. Methodological inconsistencies related to the measurement of parental influences may be a contributing factor. The purpose of this article is to review the extant peer-reviewed literature related to the measurement of general and specific parental influences on youth PA. Methods A systematic review of studies measuring constructs of PA parenting was conducted. Computerized searches were completed using PubMed, MEDLINE, Academic Search Premier, SPORTDiscus, and PsycINFO. Reference lists of the identified articles were manually reviewed as well as the authors' personal collections. Articles were selected on the basis of strict inclusion criteria and details regarding the measurement protocols were extracted. A total of 117 articles met the inclusionary criteria. Methodological articles that evaluated the validity and reliability of PA parenting measures (n=10) were reviewed separately from parental influence articles (n=107). Results A significant percentage of studies used measures with indeterminate validity and reliability. A significant percentage of articles did not provide sample items, describe the response format, or report the possible range of scores. No studies were located that evaluated sensitivity to change. Conclusion The reporting of measurement properties and the use of valid and reliable measurement scales need to be improved considerably. PMID:23944923

  11. General roles of abscisic and jasmonic acids in gene activation as a result of mechanical wounding.

    PubMed Central

    Hildmann, T; Ebneth, M; Peña-Cortés, H; Sánchez-Serrano, J J; Willmitzer, L; Prat, S

    1992-01-01

    Exogenous application of abscisic acid (ABA) has been shown to induce a systemic pattern of proteinase inhibitor II (pin2) mRNA accumulation identical to that induced by mechanical wounding. Evidence is presented that the ABA-specific response is not restricted to pin2 genes but appears to be part of a general reaction to wound stress. Four other wound-induced, ABA-responsive genes that encode two additional proteinase inhibitors, the proteolytic enzyme leucine aminopeptidase, and the biosynthetic enzyme threonine deaminase were isolated from potato plants. Wounding or treatment with ABA resulted in a pattern of accumulation of these mRNAs very similar to that of pin2. ABA-deficient plants did not accumulate any of the mRNAs upon wounding, although they showed normal levels of expression upon ABA treatment. Also, application of methyl jasmonate (MeJA) induced a strong accumulation of these transcripts, both in wild-type and in ABA-deficient plants, thus supporting a role for jasmonic acid as an intermediate in the signaling pathway that leads from ABA accumulation in response to wounding to the transcriptional activation of the genes. PMID:1392612

  12. Generalized Laplacian for magnetograms of solar active region as possible predictor of strong flare.

    NASA Astrophysics Data System (ADS)

    Volobuev, D. M.; Makarenko, N. G.; Knyazeva, I. S.

    2016-02-01

    Search for predictors of strong flare produced in solar active region (AR) is important application of solar physics. Here we consider the sequence of magnetogram (LOS SDO/HMI instrument) for AR 2034, 2035 and 2036 (April 2014). All three AR were observed on the Sun at about the same time, characterized by low probability of flare events according to official forecasts of NOAA, but 2036 still produced X1-flare near the center of solar disc (April 18). We propose that Generalized Laplacian is a descriptor which could help predict this and similar events. The Laplacian is associated with the flow of Ricci curvature and with topological invariants of the observed field - Betti numbers for compact manifolds. Using discrete version of Morse theory, we consider each pixel of energy flux (B2) image as a simplex and calculate its combinatorial Bochner Laplacian. It was found that maximum of Laplacian is located near AR polarity inversion line. Evolution of total spatial variation of the Laplacian has a number of maxima in time for each of examined AR. However, the maxima in AR 2035 and AR 2034 have relatively low amplitude, while the highest maximum prefaced X1 flare in AR 2036 by about 29 hours.

  13. Is wetter better? An evaluation of over-the-counter personal lubricants for safety and anti-HIV-1 activity.

    PubMed

    Dezzutti, Charlene S; Brown, Elizabeth R; Moncla, Bernard; Russo, Julie; Cost, Marilyn; Wang, Lin; Uranker, Kevin; Kunjara Na Ayudhya, Ratiya P; Pryke, Kara; Pickett, Jim; Leblanc, Marc-André; Rohan, Lisa C

    2012-01-01

    Because lubricants may decrease trauma during coitus, it is hypothesized that they could aid in the prevention of HIV acquisition. Therefore, safety and anti-HIV-1 activity of over-the-counter (OTC) aqueous- (n = 10), lipid- (n = 2), and silicone-based (n = 2) products were tested. The rheological properties of the lipid-based lubricants precluded testing with the exception of explant safety testing. Six aqueous-based gels were hyperosmolar, two were nearly iso-osmolar, and two were hypo-osmolar. Evaluation of the panel of products showed Gynol II (a spermicidal gel containing 2% nonoxynol-9), KY Jelly, and Replens were toxic to Lactobacillus. Two nearly iso-osmolar aqueous- and both silicone-based gels were not toxic toward epithelial cell lines or ectocervical or colorectal explant tissues. Hyperosmolar lubricants demonstrated reduction of tissue viability and epithelial fracture/sloughing while the nearly iso-osmolar and silicon-based lubricants showed no significant changes in tissue viability or epithelial modifications. While most of the lubricants had no measurable anti-HIV-1 activity, three lubricants which retained cell viability did demonstrate modest anti-HIV-1 activity in vitro. To determine if this would result in protection of mucosal tissue or conversely determine if the epithelial damage associated with the hyperosmolar lubricants increased HIV-1 infection ex vivo, ectocervical tissue was exposed to selected lubricants and then challenged with HIV-1. None of the lubricants that had a moderate to high therapeutic index protected the mucosal tissue. These results show hyperosmolar lubricant gels were associated with cellular toxicity and epithelial damage while showing no anti-viral activity. The two iso-osmolar lubricants, Good Clean Love and PRÉ, and both silicone-based lubricants, Female Condom 2 lubricant and Wet Platinum, were the safest in our testing algorithm. PMID:23144863

  14. Is Wetter Better? An Evaluation of Over-the-Counter Personal Lubricants for Safety and Anti-HIV-1 Activity

    PubMed Central

    Dezzutti, Charlene S.; Brown, Elizabeth R.; Moncla, Bernard; Russo, Julie; Cost, Marilyn; Wang, Lin; Uranker, Kevin; Kunjara Na Ayudhya, Ratiya P.; Pryke, Kara; Pickett, Jim; LeBlanc, Marc-André; Rohan, Lisa C.

    2012-01-01

    Because lubricants may decrease trauma during coitus, it is hypothesized that they could aid in the prevention of HIV acquisition. Therefore, safety and anti-HIV-1 activity of over-the-counter (OTC) aqueous- (n = 10), lipid- (n = 2), and silicone-based (n = 2) products were tested. The rheological properties of the lipid-based lubricants precluded testing with the exception of explant safety testing. Six aqueous-based gels were hyperosmolar, two were nearly iso-osmolar, and two were hypo-osmolar. Evaluation of the panel of products showed Gynol II (a spermicidal gel containing 2% nonoxynol-9), KY Jelly, and Replens were toxic to Lactobacillus. Two nearly iso-osmolar aqueous- and both silicone-based gels were not toxic toward epithelial cell lines or ectocervical or colorectal explant tissues. Hyperosmolar lubricants demonstrated reduction of tissue viability and epithelial fracture/sloughing while the nearly iso-osmolar and silicon-based lubricants showed no significant changes in tissue viability or epithelial modifications. While most of the lubricants had no measurable anti-HIV-1 activity, three lubricants which retained cell viability did demonstrate modest anti-HIV-1 activity in vitro. To determine if this would result in protection of mucosal tissue or conversely determine if the epithelial damage associated with the hyperosmolar lubricants increased HIV-1 infection ex vivo, ectocervical tissue was exposed to selected lubricants and then challenged with HIV-1. None of the lubricants that had a moderate to high therapeutic index protected the mucosal tissue. These results show hyperosmolar lubricant gels were associated with cellular toxicity and epithelial damage while showing no anti-viral activity. The two iso-osmolar lubricants, Good Clean Love and PRÉ, and both silicone-based lubricants, Female Condom 2 lubricant and Wet Platinum, were the safest in our testing algorithm. PMID:23144863

  15. Space engine safety system

    NASA Technical Reports Server (NTRS)

    Maul, William A.; Meyer, Claudia M.

    1991-01-01

    A rocket engine safety system is designed to initiate control procedures which will minimize damage to the engine and vehicle or test stand in the event of an engine failure. This report describes the features and the implementation issues associated with rocket engine safety systems. Specific concerns of safety systems applied to a space-based engine and long duration space missions are discussed. Examples of safety system features and architectures are given from recent safety monitoring investigations conducted for the Space Shuttle Main Engine and for future liquid rocket engines. Also, a general design and implementation process for rocket engine safety systems is presented.

  16. Space engine safety system

    NASA Technical Reports Server (NTRS)

    Maul, William A.; Meyer, Claudia M.

    1991-01-01

    A rocket engine safety system was designed to initiate control procedures to minimize damage to the engine or vehicle or test stand in the event of an engine failure. The features and the implementation issues associated with rocket engine safety systems are discussed, as well as the specific concerns of safety systems applied to a space-based engine and long duration space missions. Examples of safety system features and architectures are given, based on recent safety monitoring investigations conducted for the Space Shuttle Main Engine and for future liquid rocket engines. Also, the general design and implementation process for rocket engine safety systems is presented.

  17. Sexual Activity and Impairment in Women with Systemic Sclerosis Compared to Women from a General Population Sample

    PubMed Central

    Levis, Brooke; Burri, Andrea; Hudson, Marie; Baron, Murray; Thombs, Brett D.

    2012-01-01

    Objective Reports of low sexual activity rates and high impairment rates among women with chronic diseases have not included comparisons to general population data. The objective of this study was to compare sexual activity and impairment rates of women with systemic sclerosis (SSc) to general population data and to identify domains of sexual function driving impairment in SSc. Methods Canadian women with SSc were compared to women from a UK population sample. Sexual activity and, among sexually active women, sexual impairment were evaluated with a 9-item version of the Female Sexual Function Index (FSFI). Results Among women with SSc (mean age = 57.0 years), 296 of 730 (41%) were sexually active, 181 (61%) of whom were sexually impaired, resulting in 115 of 730 (16%) who were sexually active without impairment. In the UK population sample (mean age = 55.4 years), 956 of 1,498 women (64%) were sexually active, 420 (44%) of whom were impaired, with 536 of 1,498 (36%) sexually active without impairment. Adjusting for age and marital status, women with SSc were significantly less likely to be sexually active (OR = 0.34, 95%CI = 0.28–0.42) and, among sexually active women, significantly more likely to be sexually impaired (OR = 1.88, 95%CI = 1.42–2.49) than general population women. Controlling for total FSFI scores, women with SSc had significantly worse lubrication and pain scores than general population women. Conclusions Sexual functioning is a problem for many women with scleroderma and is associated with pain and poor lubrication. Evidence-based interventions to support sexual activity and function in women with SSc are needed. PMID:23251692

  18. Towards Observational Astronomy of Jets in Active Galaxies from General Relativistic Magnetohydrodynamic Simulations

    NASA Astrophysics Data System (ADS)

    Anantua, Richard; Roger Blandford, Jonathan McKinney and Alexander Tchekhovskoy

    2016-01-01

    We carry out the process of "observing" simulations of active galactic nuclei (AGN) with relativistic jets (hereafter called jet/accretion disk/black hole (JAB) systems) from ray tracing between image plane and source to convolving the resulting images with a point spread function. Images are generated at arbitrary observer angle relative to the black hole spin axis by implementing spatial and temporal interpolation of conserved magnetohydrodynamic flow quantities from a time series of output datablocks from fully general relativistic 3D simulations. We also describe the evolution of simulations of JAB systems' dynamical and kinematic variables, e.g., velocity shear and momentum density, respectively, and the variation of these variables with respect to observer polar and azimuthal angles. We produce, at frequencies from radio to optical, fixed observer time intensity and polarization maps using various plasma physics motivated prescriptions for the emissivity function of physical quantities from the simulation output, and analyze the corresponding light curves. Our hypothesis is that this approach reproduces observed features of JAB systems such as superluminal bulk flow projections and quasi-periodic oscillations in the light curves more closely than extant stylized analytical models, e.g., cannonball bulk flows. Moreover, our development of user-friendly, versatile C++ routines for processing images of state-of-the-art simulations of JAB systems may afford greater flexibility for observing a wide range of sources from high power BL-Lacs to low power quasars (possibly with the same simulation) without requiring years of observation using multiple telescopes. Advantages of observing simulations instead of observing astrophysical sources directly include: the absence of a diffraction limit, panoramic views of the same object and the ability to freely track features. Light travel time effects become significant for high Lorentz factor and small angles between

  19. 76 FR 50748 - Information Collection Activity: Production Safety Systems, Revision of a Collection; Submitted...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-16

    ... Bureau of Ocean Energy Management, Regulation and Enforcement Information Collection Activity: Production...; Comment Request AGENCY: Bureau of Ocean Energy Management, Regulation and Enforcement (BOEMRE), Interior... of Ocean Energy Management, Regulation and Enforcement; Attention: Cheryl Blundon; 381 Elden...

  20. 78 FR 65661 - Agency Information Collection Activities; Proposed Collection; Comment Request; Food Safety Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration Agency Information Collection Activities; Proposed.... Department of Health and Human Services, ``Healthy People 2020--Improving the Lives of Americans,'' July...

  1. IT and Activity Displacement: Behavioral Evidence from the U.S. General Social Survey (GSS)

    ERIC Educational Resources Information Center

    Robinson, John P.; Martin, Steven

    2009-01-01

    In order to track social change during a period of the rapid advances brought about by new information technologies (IT), a targeted module of IT-relevant and Internet questions was added to the 2000, 2002 and 2004 samples of the General Social Survey (GSS). The general issue inherent in and guiding the questions asked (as well as the analyses…

  2. 77 FR 34409 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; General...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... Federal Register on February 27, 2012 (77 FR 11593). Interested parties are encouraged to send comments to...; General Inquiries to State Agency Contacts ACTION: Notice. SUMMARY: The Department of Labor (DOL) is..., ``General Inquiries to State Agency Contacts,'' to the Office of Management and Budget (OMB) for review...

  3. 77 FR 8880 - Agency Information Collection Activities; Proposed Collection; Comment Request; General Licensing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... Collection; Comment Request; General Licensing Provisions; Section 351(k) Biosimilar Applications AGENCY... appropriate, and other forms of information technology. General Licensing Provisions; Section 351(K... sections 7001 through 7003 of the Affordable Care Act.) Section 351(k) of the PHS Act (42 U.S.C....

  4. Flexibility and Coordination among Acts of Visualization and Analysis in a Pattern Generalization Activity

    ERIC Educational Resources Information Center

    Nilsson, Per; Juter, Kristina

    2011-01-01

    This study aims at exploring processes of flexibility and coordination among acts of visualization and analysis in students' attempt to reach a general formula for a three-dimensional pattern generalizing task. The investigation draws on a case-study analysis of two 15-year-old girls working together on a task in which they are asked to calculate…

  5. Combined control effects of brake and active suspension control on the global safety of a full-car nonlinear model

    NASA Astrophysics Data System (ADS)

    Tchamna, Rodrigue; Youn, Edward; Youn, Iljoong

    2014-05-01

    This paper focuses on the active safety of a full-vehicle nonlinear model during cornering. At first, a previously developed electronic stability controller (ESC) based on vehicle simplified model is applied to the full-car nonlinear model in order to control the vehicle yaw rate and side-slip angle. The ESC system was shown beneficial not only in tracking the vehicle path as close as possible, but it also helped in reducing the vehicle roll angle and influences ride comfort and road-holding capability; to tackle that issue and also to have better attitude motion, making use of optimal control theory the active suspension control gain is developed from a vehicle linear model and used to compute the active suspension control force of the vehicle nonlinear model. The active suspension control algorithm used in this paper includes the integral action of the suspension deflection in order to make zero the suspension deflection steady state and keep the vehicle chassis flat. Keeping the chassis flat reduces the vehicle load transfer and that is helpful for road holding and yaw rate tracking. The effects of the two controllers when they work together are analysed using various computer simulations with different steering wheel manoeuvres.

  6. Criticality safety basics, a study guide

    SciTech Connect

    V. L. Putman

    1999-09-01

    This document is a self-study and classroom guide, for criticality safety of activities with fissile materials outside nuclear reactors. This guide provides a basic overview of criticality safety and criticality accident prevention methods divided into three parts: theory, application, and history. Except for topic emphasis, theory and history information is general, while application information is specific to the Idaho National Engineering and Environmental Laboratory (INEEL). Information presented here should be useful to personnel who must know criticality safety basics to perform their assignments safely or to design critically safe equipment or operations. However, the guide's primary target audience is fissile material handler candidates.

  7. Migration studies to assess the safety in use of a new antioxidant active packaging.

    PubMed

    Tovar, Laura; Salafranca, Jesús; Sánchez, Cristina; Nerín, Cristina

    2005-06-29

    Both specific and overall migration tests have been applied to new experimental food packaging-active plastic films with antioxidant properties, including in its composition a natural rosemary extract. Determination of volatile and semivolatile compounds migrating from plastic to the four established simulants showed that both specific and overall migration was very low. The results obtained gave values 20 times lower than the established limits in the worst case. So, from the point of view of health risk, the new active packaging can be considered as safe. Analytical procedure used provided the necessary information about the migration behavior, with good analytical characteristics and detection limits in the sub mug kg(-1) range. Besides, no significant difference was found between laboratory and factory-made samples, which is an important issue for industrial production, the next step in the development of the new antioxidant active film. PMID:15969507

  8. [The efficacy and safety of activated vitamin D for CKD-MBD].

    PubMed

    Hayakawa, Nobuki; Suzuki, Atsushi

    2016-09-01

    Metabolic bone disorders that are represented by secondary hyperparathyroidism occur with the progression of chronic kidney disease(CKD). The administration of activated vitamin D is expected to improve high-turnover bone disorders and is widely used for the management of bone mineral diseases in patients with CKD and end-stage renal disease. CKD is an underlying disease of secondary osteoporosis and coexists with primary osteoporosis at a high rate. With regard to osteoporosis patients with renal insufficiency, the administration of activated vitamin D is also thought to reduce the fracture incidence by both increasing bone mass and reducing falls. PMID:27561349

  9. Aerosol Gemcitabine: Preclinical Safety and In Vivo Antitumor Activity in Osteosarcoma-Bearing Dogs

    PubMed Central

    Crabbs, Torrie A.; Wilson, Dennis W.; Cannan, Virginia A.; Skorupski, Katherine A.; Gordon, Nancy; Koshkina, Nadya; Kleinerman, Eugenie; Anderson, Peter M.

    2010-01-01

    Abstract Background Osteosarcoma is the most common skeletal malignancy in the dog and in young humans. Although chemotherapy improves survival time, death continues to be attributed to metastases. Aerosol delivery can provide a strategy with which to improve the lung drug delivery while reducing systemic toxicity. The purpose of this study is to assess the safety of a regional aerosol approach to chemotherapy delivery in osteosarcoma-bearing dogs, and second, to evaluate the effect of gemcitabine on Fas expression in the pulmonary metastasis. Methods We examined the systemic and local effects of aerosol gemcitabine on lung and pulmonary metastasis in this relevant large-animal tumor model using serial laboratory and arterial blood gas analysis and histopathology and immunohistochemistry, respectively. Results and Conclusions Six hundred seventy-two 1-h doses of aerosol gemcitabine were delivered. The treatment was well tolerated by these subjects with osteosarcoma (n = 20). Aerosol-treated subjects had metastatic foci that demonstrated extensive, predominately central, intratumoral necrosis. Fas expression was decreased in pulmonary metastases compared to the primary tumor (p = 0.008). After aerosol gemcitabine Fas expression in the metastatic foci was increased compared to lung metastases before treatment (p = 0.0075), and even was higher than the primary tumor (p = 0.025). Increased apoptosis (TUNEL) staining was also detected in aerosol gemcitabine treated metastasis compared to untreated controls (p = 0.028). The results from this pivotal translational study support the concept that aerosol gemcitabine may be useful against pulmonary metastases of osteosarcoma. Additional studies that evaluate the aerosol route of administration of gemcitabine in humans should be safe and are warranted. PMID:19803732

  10. Clinical activity and safety of Pembrolizumab in Ipilimumab pre-treated patients with uveal melanoma

    PubMed Central

    Karydis, Ioannis; Chan, Pui Ying; Wheater, Matthew; Arriola, Edurne; Szlosarek, Peter W.; Ottensmeier, Christian H.

    2016-01-01

    ABSTRACT Background: Untreated metastatic uveal melanoma (UM) carries a grave prognosis. Unlike cutaneous melanoma (CM), there are no established treatments known to significantly improve outcomes for a meaningful proportion of patients. Inhibition of the PD1–PDL1 axis has shown promise in the management of CM and we here report a two center experience of UM patients receiving pembrolizumab. Methods: To assess the efficacy and safety of pembrolizumab, we retrospectively analyzed outcome data of 25 consecutive UM patients participating in the MK3475 expanded access program (EAP) who received pembrolizumab at 2 mg/kg 3 weekly. Tumor assessment was evaluated using RECIST 1.1 and immune-related Response Criteria (irRC) by CT scanning. Toxicity was recorded utilizing Common Terminology Criteria for Adverse Events (“CTCAE”) v4.03. Results: Twenty-five patients were identified receiving a median of six cycles of treatment. Two patients achieved a partial response and six patients stable disease. After a median follow-up of 225 d median progression free survival (PFS) was 91 d and overall survival (OS) was not reached. There was a significant trend for improved outcomes in patients with extrahepatic disease progression as opposed to liver only progression at the outset. Five patients experienced grade 3 or 4 adverse events (AEs); there were no treatment related deaths. Conclusions: Pembrolizumab 2mg/kg q3w is a safe option in UM patients. Disease control rates, particularly in the subgroup of patients without progressive liver disease at the outset are promising; these results merit further investigation in clinical trials possibly incorporating liver targeted treatment modalities.

  11. 77 FR 24257 - Railroad Safety Advisory Committee (RSAC); Working Group Activity Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-23

    ... announcement of working group activities and status reports of November 28, 2011 (76 FR 72997). The 45th full... Rulemaking (NPRM) was published on August 24, 2006 (71 FR 50275), and was open for comment until October 23... emergency communication, emergency egress, and rescue access, was published on February 1, 2008 (73 FR...

  12. 76 FR 72997 - Railroad Safety Advisory Committee (RSAC); Working Group Activity Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... announcement of working group activities and status reports of December 7, 2010 (75 FR 76070). The 44th full..., 2006 (71 FR 50275), and was open for comment until October 23, 2006. The working group agreed upon... rescue access, was published on February 1, 2008 (73 FR 6370). The task force met on October 17-18,...

  13. 75 FR 51525 - Railroad Safety Advisory Committee (RSAC); Working Group Activity Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    ... announcement of working group activities and status reports of January 29, 2010 (75 FR 4904). The 41st full... October 11, 2005. The Notice of Proposed Rulemaking (NPRM) was published on August 24, 2006 (71 FR 50275... published on February 1, 2008 (73 FR 6370). The Task Force met on October 17-18, 2007, and reached...

  14. Sample Heat, Activity, Reactivity, and Dose Analysis for Safety Analysis of Irradiations in a Research Reactor.

    Energy Science and Technology Software Center (ESTSC)

    1987-12-01

    SHARDA is a program for assessing sample heating rates, activities produced and reactivity load caused while irradiating a small sample in a well thermalized research reactor like CIRUS. It estimates the sample cooling or lead shielding requirements to limit the gamma-ray dose rates due to the irradiated sample within permissible levels.

  15. 49 CFR 388.7 - Joint administrative activities related to enforcement of safety and hazardous materials laws and...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS COOPERATIVE AGREEMENTS WITH STATES § 388.7 Joint... administrative action, the Field Administrator and the appropriate State authority shall, when...

  16. 49 CFR 388.7 - Joint administrative activities related to enforcement of safety and hazardous materials laws and...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS COOPERATIVE AGREEMENTS WITH STATES § 388.7 Joint... administrative action, the Field Administrator and the appropriate State authority shall, when...

  17. A general approach of the active concept of microstrip antennas and arrays based on the loaded scatterer theory

    NASA Astrophysics Data System (ADS)

    Gillard, Raphael; Legay, Herve; Floch, Jean-Marie; Citerne, Jacques

    1991-06-01

    A quantitative and general approach of the active antenna concept concretized in planar type microstrip technologies is proposed using integral equation techniques associated with the multiport representation of loaded scatterers. Two configurations based on this concept, involving an electromagnetically fed microstrip dipole combined with either passive loads simulating a monolithic switch or active loads simulating a monolithic amplifier, are computed to illustrate the extended capacities of this new approach. Theoretical results on matching characteristics are compared to measurements achieved in X band.

  18. Clinical activity and safety of the dual pathway inhibitor rigosertib for higher risk myelodysplastic syndromes following DNA methyltransferase inhibitor therapy.

    PubMed

    Silverman, Lewis R; Greenberg, Peter; Raza, Azra; Olnes, Matthew J; Holland, James F; Reddy, Premkumar; Maniar, Manoj; Wilhelm, Francois

    2015-06-01

    Rigosertib (ON 01910.Na) is an inhibitor of the phosphoinositide 3-kinase and polo-like kinase pathways that induces mitotic arrest and apoptosis in neoplastic cells, while sparing normal cells. Our purpose is to summarize the clinical activity and safety of intravenous (IV) rigosertib delivered by an external ambulatory infusion pump in patients with refractory anemia with excess blasts-1, -2, or, -t myelodysplastic syndromes (MDS) following prior treatment with DNA methyltransferase (DNMT) inhibitors. A total of 39 patients with MDS who fulfilled these criteria were enrolled in four phase 1-2 clinical trials of IV rigosertib. Thirty five (88%) had higher risk disease according to the Revised International Prognostic Scoring System. Median overall survival for this group of 39 patients was 35 weeks. Of 30 evaluable patients with follow-up bone marrow biopsies, 12 (40%) achieved complete (n = 5) or partial (n = 7) bone marrow blast responses. In addition, 15 patients achieved stabilization of bone marrow blasts. One patient with a complete bone marrow response also achieved a complete cytogenetic response. A second patient with stable bone marrow blasts achieved a partial cytogenetic response. Two of the responding patients and three patients with stable disease had hematological improvements. Rigosertib-induced bone marrow blast decreases and stability appeared to be predictive of prolonged survival. IV rigosertib had a favorable safety profile without significant myelosuppression. Most common drug-related toxicities included fatigue, diarrhea, nausea, dysuria, and hematuria. In summary, IV rigosertib is well tolerated and has clinical activity in patients with higher risk MDS following DNMT inhibitor treatment. A multinational pivotal phase 3 randomized clinical trial of rigosertib versus best supportive care for patients with MDS with excess blasts following prior treatment with DNMT inhibitors (ONTIME: ON 01910.Na Trial In Myelodysplastic SyndromE) has recently

  19. 78 FR 52519 - Agency Information Collection Activities; Comment Request; Student Assistance General Provisions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... K--Cash Management AGENCY: Federal Student Aid (FSA), Department of Education (ED). ACTION: Notice...: Student Assistance General Provisions--Subpart K--Cash Management. OMB Control Number: 1845-0049. Type...

  20. Slope Stability: Factor of Safety along the Seismically Active Continental Slope Offshore Sumatra

    NASA Astrophysics Data System (ADS)

    Patton, J. R.; Goldfinger, C.; Djadjadihardja, Y.; None, U.

    2013-12-01

    Recent papers have documented the probability that turbidites deposited along and downslope of subduction zone accretionary prisms are likely the result of strong ground shaking from great earthquakes. Given the damaging nature of these earthquakes, along with the casualties from the associated tsunamis, the spatial and temporal patterns of these earthquakes can only be evaluated with paleoseismologic coring and seismic reflection methods. We evaluate slope stability for seafloor topography along the Sunda subduction offshore Sumatra, Indonesia. We use sediment material properties, from local (Sumatra) and analogous sites, to constrain our estimates of static slope stability Factor of Safety (FOS) analyses. We then use ground motion prediction equations (GMPE's) to estimate ground motion intensity (Arias Intensity, AI) and acceleration (Peak Ground Acceleration, PGA), as possibly generated by fault rupture, to constrain seismic loads for pseudostatic slope stability FOS analyses. The ground motions taper rapidly with distance from the fault plane, consistent with ground motion - fault distance relations measured during the 2011 Tohoku-Oki subduction zone earthquake. Our FOS analyses include a Morgenstern method of slices probabilistic analysis for 2-D profiles along with Critical Acceleration (Ac) and Newmark Displacement (Dn) analysis of multibeam bathymetry of the seafloor. In addition, we also use estimates of ground motion modeled with a 2004 Sumatra-Andaman subduction zone (SASZ) earthquake fault slip model, to also compare with our static FOS analyses of seafloor topography. All slope and trench sites are statically stable (FOS < 1) and sensitive to ground motions generated by earthquakes of magnitude greater than 7. We conclude that for earthquakes of magnitude 6 to 9, PGA of 0.4-0.6 to 1.4-2.5 g would be expected, respectively, from existing GMPE's. However, saturation of accelerations in the accretionary wedge may limit actual accelerations to less than 1