Fault history of the Pribilof Island and its relevance to bottom stability in the St. George Basin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hopkins, D.M.

1976-04-01

This study evaluates frequency of faulting and volcanic eruptions on the Pribilof Islands and in nearby waters, examines rates and directions of changes in the island shorelines during the 20th Century, and investigates the nature of the soils and thier susceptibility to erosion after disturbance. Volcanos have been active in the Pribilof Island area throughout the last 8 my, activity during the last 300,000 years and has been confined to the vicinity of St. Paul Island. Eruptions recur at intervals of about 10,000 years. Faulting is also an ongoing process. Fault movements recur at rather long but still unknown intervals.more » Although the recurrence interval of movement on individual faults is long, the fault hazard is significant, because faluts cross any possible path for a pipeline connecting production areas in the St. George Basin with terminal facilities on the Pribilof Islands. The sandy beaches and sandy soils of St. Paul Island are sensitive to human activity. Perturbations related to construction of logistic bases and pipeline and transhipment facilities are likely to result in extensive changes in the beaches and loss of surface soils by wind deflation.« less

Suburban School Opens Elementary Campus in the Heart of Memphis: St. George's Independent School, Memphis, Tennessee

ERIC Educational Resources Information Center

Stewart, Sarah

2016-01-01

St. George's has nearly 1,150 students on three campuses: an elementary campus in Germantown and a middle/upper school campus in Collierville, both suburbs of Memphis, and a second elementary campus in Memphis. The Memphis campus serves 140 students in pre-K-5th grade. All Memphis campus students receive financial aid based on need, and…

Evaluation of antimicrobial resistance among Salmonella and Shigella isolates in the University Hospital "St. George," Plovdiv, Bulgaria.

PubMed

Petrov, Michael M; Petrova, Atanaska; Stanimirova, Irina; Mircheva-Topalova, Marina; Koycheva, Lalka; Velcheva, Rayna; Stoycheva-Vartigova, Mariana; Raycheva, Ralitsa; Asseva, Galina; Petrov, Petar; Kardjeva, Velichka; Murdjeva, Marianna

2017-03-01

The aim of this work is to study the epidemiology and antimicrobial resistance to the most commonly used antibiotics for the treatment of acute gastroenteritis caused by Salmonella and Shigella at the largest Bulgarian hospital-University Hospital "St. George," Plovdiv-for the period 2009-2013. Two hundred ninety strains were in vitro tested for resistance to 15 antimicrobial agents. The presence of extended-spectrum beta-lactamases (ESBLs) was demonstrated by a variety of specialized tests. For comparison, a collection of 28 strains submitted by the National Reference Laboratory (NRL) "Enteric Infections" at the National Center of Infectious and Parasitic Diseases (NCIPD), Sofia, was also tested for the production of ESBLs. In isolates, phenotypically demonstrated as ESBL producers, polymerase chain reaction (PCR) detection of the genes bla-CTX-M, bla-SHV, and bla-TEM was performed. Among the 290 tested isolates, only two- Salmonella serotype Livingstone and Shigella flexneri-were phenotypically proven to be ESBL producers. Only 4 strains from the collection of 28, submitted from the NRL "Intestinal Infections" in NCIPD, Sofia, were phenotypically confirmed as ESBL producers. The presence of the bla-CTX-M gene was detected in all of the tested strains (4 from NRL, NCIPD, Sofia, and 2 from the University Hospital St. George, Plovdiv), the bla-SHV gene only in strain S. Livingstone from Plovdiv, and the bla-TEM gene in two from Sofia and one (again S. Livingstone) from Plovdiv. In conclusion, Salmonella and Shigella isolates from patients hospitalized at the University Hospital St. George, Plovdiv, with acute gastroenteritis demonstrate good susceptibility to the most commonly used antibiotic agents, including azithromycin.

AIDS. 1st annual George H. Gallup Memorial Survey.

PubMed

1988-06-01

Acquired immunodeficiency syndrome (AIDS) was selected as the subject for the 1st annual George H Gallup Memorial Survey. This survey, conducted in August 1987-April 1988 in 35 countries, measured the level of awareness of AIDS, the extent of concern about AIDS, knowledge, changes in behavior resulting form the AIDS epidemic, and attitudes toward people with AIDS. Overall, the poll's findings attest to the effectiveness of the health education efforts of governmental and nongovernmental organizations. Awareness that AIDS poses an urgent international health problem was almost universal in the 35 samples. In about half of these countries, AIDS was identified as the most important national health problem; in the remaining countries, AIDS was ranked 2nd to cancer. The proportion of respondents expressing a fear of personally contracting the AIDS virus ranged from lows of under 10% in most of Europe to a high of 45% among South African blacks. A majority of respondents in the US, Colombia, the Philippines, Brazil, Nigeria, Ecuador, El Salvador, and Chile believed that AIDS will soon spread beyond current risk groups to the general population. Despite widespread awareness of the grave threat posed by AIDS, insufficient numbers of respondents reported that they had made specific behavioral changes intended to protect themselves form HIV infection. Overall, about half of those interviewed indicated they are now more cautious in their choice of sexual partners; similarly, about half are using condoms more or for the 1st time.

Assessment of respiration-related quality of life of Chinese patients with silicosis and its influencing factors using the St. George's Respiratory Questionnaire (SGRQ).

PubMed

Liu, Hongbo; Yan, Bo; Han, Bing; Sun, Jinkai; Yang, Yang; Chen, Jie

2012-06-01

The aims are to assess respiration-related quality of life using the St. George Respiratory Questionnaire and determine its influencing factors among patients with silicosis in China. The incidence of silicosis had an increasing trend in recent years in developing countries. Although the majority of patients with silicosis are in therapy routinely, the patients' quality of life has been impaired because silicosis cannot be cured. The study on quality of life of patients with silicosis is few, and clinical physicians have difficulty in planning to promote quality of life of patients with silicosis according to the current health situation. A cross-sectional design was used for this study. A survey was performed on patients with silicosis by face-to-face interview in the Shenyang No. 9 Hospital in China. The St. George Respiratory Questionnaire was used to assess respiration-related quality of life. In all 208 enrolled patients with silicosis, symptoms, activity and impacts scores were 56·02, 56·46 and 52·33, respectively. Lower impacts scores were found comparing with symptoms and activity ones. Patient age was associated with an expected decrease in respiration-related quality of life. Patients with longer duration of exposure had higher total scores of the St. George Respiratory Questionnaire, indicating worse quality of life. Patients with more co-morbidities reported worse quality of life. Patients with silicosis were found relatively moderate respiration-related quality of life. Shortening dust exposure, decreasing the number of co-morbidity and controlling the occurrence of pulmonary tuberculosis could improve respiration-related quality of life. As indicated by the results of this study, the number of co-morbidity negatively impact the quality of life of patients with silicosis. Clinical physicians and nurses should pay close attention to the co-morbidity to promote quality of life of patients with silicosis according to the current health situation. �

Alaska OCS socioeconomic studies program: St. George basin petroleum development scenarios, Anchorage impact analysis. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ender, R.L.; Gorski, S.

1981-10-01

The report consists of an update to the Anchorage socioeconomic and physical baseline and infrastructure standards used to forecast impacts with and without OCS oil and gas development in Alaska. This material is found in Technical Report 43, Volumes 1 and 2 entitled 'Gulf of Alaska and Lower Cook Inlet Petroleum Development Scenarios, Anchorage Socioeconomic and Physical Baseline and Anchorage Impact Analysis.' These updates should be read in conjunction with the above report. In addition, the Anchorage base case and petroleum development scenarios for the St. George Basin are given. These sections are written to stand alone without reference.

St. George Mivart as Popularizer of Zoology in Britain and America, 1869-1881.

PubMed

Swain, Emma E

2017-12-01

Recent scholarly attentions have shifted from key actors within the scientific elite and religious authorities to scientific practitioners and popularizers who used science to pursue a wide variety of cultural purposes. The Roman Catholic zoologist St. George Mivart (1827-1900) has typically been cast as a staunch anti-Darwinian ostracized by Darwin's inner circle of scientific naturalists. Understood as a popularizer of science, his position can be re-thought. Mivart did not operate on the periphery of Victorian science. Instead, his notable contributions to the fields of zoology and anatomy and his participation in debates about the origin of the human mind, consciousness, and soul made him a central figure in the changing landscape of late-Victorian scientific culture. Through the popular periodical press and his anatomy textbook for beginners, Mivart secured a reputation as a key spokesman for science and gained authority as a leading critic of agnostic scientific naturalism. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

DOCTORS' LIABILITY TO THE PATIENT'S RELATIVES IN GENETIC MEDICINE: ABC V St George's Healthcare NHS trust[2015] EWHC 1394 (QB).

PubMed

Gilbar, Roy; Foster, Charles

2016-01-01

This comment analyses the recent High Court's decision in ABC v St George's Healthcare NHS Trust. In this case, the court struck out a claim brought by a patient's daughter against her father's doctors for their failure to warn her of his hereditary disease. The claimant argued that the doctors' failure caused her harm and violated her rights under the European Convention on Human Rights. It is argued in this comment that the judge should have accepted the claimant's application. © The Author 2015. Published by Oxford University Press; all rights reserved. For Permissions, please email: journals.permissions@oup.com.

Alaska OCS socioeconomic studies program: St. George basin and North Aleutian Shelf commercial fishing industry analysis. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tobolski, J.; Guluka, L.; Trefethen, D.

1981-10-01

This report consists of an update of the data base and analysis of the potential impacts to commercial fishing of proposed Outer Continental Shelf oil and gas lease sales in the St. George Basin and North Aleutian Shelf, situated in the Bering Sea off Alaska. Impacts on the Bristol Bay fishery are also discussed. Competition for labor between the fishing and oil industries is examined, as well as an analysis of risk of collision among vessels in the OCS areas. A description of the fisheries resources of the area is followed by an analysis of loss of access to fishingmore » grounds, and loss of or damage to gear. Impacts on the recreational fishery are also discussed.« less

Flood risk analysis model in the village of St. George/Danube Delta

NASA Astrophysics Data System (ADS)

Armas, I.; Dumitrascu, S.; Nistoran, D.

2009-04-01

the Danube Delta. The study area is situated at the mouth of the St. George river branch, which suffered a series of interventions resulting with the shortening with 31 km (period 1984-1988). As a direct result, the medium speed of the water grew along with the both liquid and solid flows. In fact, this is only an example of the human activity that took place in the Danube Delta starting with the second half of the last century that influenced the hydrological system for a better use of the natural resources offered by the delta. The study is structured in two stages: the analysis of the hydrological hazard together with the simulation of a series of scenarios concerning floods at various flows and the risk analysis, expressed in the shape of the calculus of the material damage. In the study of the hazard, the methodology was based on the analysis of water depth and velocity maps, done in various flow scenarios, to which were added correlations between flood risk maps with satellite pictures, cadastral plans and field data by using GIS functions. In addition, the field investigations conducted in September 2008 focused on collecting the data necessary in the assessment of the buildings. The observations that synthesize the features of each construction included in the analysis were also stored in ArcGis in the shape of a table of attributes. This information reveals the indicators used in the analysis of the vulnerability of the residences: number of floors, height, construction type, infrastructure and price per property. The analysis revealed an increased degree of the area visibility, pointing out not only certain sectors affected by floods, but also the problems that occurred at the more detailed level of the residences. In addition, the cartographic material plays also an important part in the development of a proper public awareness strategy.

Carbon-isotope stratigraphy of the Lower Ordovician succession in Northeast Greenland: Implications for correlations with St. George Group in western Newfoundland (Canada) and beyond

NASA Astrophysics Data System (ADS)

Azmy, Karem; Stouge, Svend; Christiansen, Jørgen L.; Harper, Dave A. T.; Knight, Ian; Boyce, Douglas

2010-03-01

The Lower Ordovician sequence on the Ella Ø Island in Northeast (N-E) Greenland is a thick shallow marine platform carbonate sequence (˜ 1415 m thick) and constitutes the major part of the Kong Oscar Fjord Group. It consists, from bottom to top, of the Antiklinalbugt, Septembersø, and Cape Weber formations, which are believed to be respectively coeval with the Watts Bight, Boat Harbour, and Catoche formations of the St. George Group in western Newfoundland, Canada. Samples were collected from outcrops at high-resolution intervals and micritic materials were extracted by microdrilling after screening their petrographic and geochemical criteria to evaluate the degree of preservation. The δ13C and δ18O values of well preserved micrite microsamples range from -5.2‰ to 0.5‰ (VPDB) and from -10.3‰ to-6.5‰ (VPDB), respectively. The δ13C carb profile of the sequence reveals few negative shifts, which vary between ˜ 2 and 4.7‰ and are associated with unconformities/disconformities, thus reflecting the effect of significant sea-level changes. The δ13C shifts can be correlated with counterparts on the St. George Group and also on the global Lower Ordovician δ13C profiles around the early Tremadoc (˜ 2.3‰) and late Tremadoc-early Arenig (˜ 4.7‰).

The spatial variability of nitrogen and phosphorus concentration in a sand aquifer influenced by onsite sewage treatment and disposal systems: a case study on St. George Island, Florida.

PubMed

Corbet, D Reide; Dillon, Kevin; Burnett, William; Schaefer, Geoff

2002-01-01

Groundwater from a shallow freshwater lens on St. George Island, a barrier island located in the Panhandle of Florida, eventually discharges into Apalachicola Bay or the Gulf of Mexico. Nutrient concentrations in groundwaters were monitored downfield from three onsite sewage treatment and disposal systems (OSTDS) on the island. Estimates of natural groundwater nutrient concentrations were obtained from an adjacent uninhabited island. Silicate, which was significantly higher in the imported drinking water relative to the surficial aquifer on St. George Island (12.2+/-1.9 mg Si l(-1) and 2.9+/-0.2 mg Si l(-1), respectively), was used as a natural conservative tracer. Our observations showed that nitrogen concentrations were attenuated to a greater extent than that of phosphorus relative to the conservative tracer. At the current setback distance (23 m), both nitrogen and phosphate concentrations are still elevated above natural levels by as much as 2 and 7 times, respectively. Increasing the setback distance to 50 m and raising the drainfields 1 m above the ground surface could reduce nutrient levels to natural concentrations (1.1+/-0.1 mg N l(-1), 0.20+/-0.02 mg P l(-1)).

George Scott | NREL

Science.gov Websites

George Scott George Scott Researcher IV-Software Engineering George.Scott@nrel.gov | 303-384-6903 Orcid ID http://orcid.org/0000-0002-7983-3050 George joined NREL (then SERI) in 1985. He specializes in turbines and wind plants. Before joining NREL, George was a research geophysicist with Superior Oil in

14. 1862 LITHOGRAPH SHOWING ST. DAVID'S CHURCH IN WINTER SCENE. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. 1862 LITHOGRAPH SHOWING ST. DAVID'S CHURCH IN WINTER SCENE. Photocopied from George Smith's book, History of Delaware County, Penna., 1862 - St. David's Church (Episcopal), Valley Forge Road (Newtown Township), Wayne, Delaware County, PA

Geologic controls on the recent evolution of oyster reefs in Apalachicola Bay and St. George Sound, Florida

USGS Publications Warehouse

Twichell, D.; Edmiston, L.; Andrews, Brian; Stevenson, W.; Donoghue, J.; Poore, Richard; Osterman, Lisa E.

2010-01-01

Apalachicola Bay and St. George Sound contain the largest oyster fishery in Florida, and the growth and distribution of the numerous oyster reefs here are the combined product of modern estuarine conditions in the bay and its late Holocene evolution. Sidescan-sonar imagery, bathymetry, high-resolution seismic profiles, and sediment cores show that oyster beds occupy the crests of a series of shoals that range from 1 to 7 km in length, trend roughly north-south perpendicular to the long axes of the bay and sound, and are asymmetrical with steeper sides facing to the west. Surface sediment samples show that the oyster beds consist of shelly sand, while much of the remainder of the bay floor is covered by mud delivered by the Apalachicola River. The present oyster reefs rest on sandy delta systems that advanced southward across the region between 6400 and 4400 yr BP when sea level was 4–6 m lower than present. Oysters started to colonize the region around 5100 yr BP and became extensive by 1200 and 2400 yr BP. Since 1200 yr BP, their aerial extent has decreased due to burial of the edges of the reefs by the prodelta mud that continues to be supplied by the Apalachicola River. Oyster reefs that are still active are narrower than the original beds, have grown vertically, and become asymmetrical in cross-section. Their internal bedding indicates they have migrated westward, suggesting a net westerly transport of sediment in the bay.

Famous Americans: George Washington & Abraham Lincoln.

ERIC Educational Resources Information Center

Fleming, Maria

Introducing students in grade 1-3 to George Washington and Abraham Lincoln, this book presents thematic units that present biographical information, and literature links such as poems, songs, stories, cross-curricular activities, and hands-on reproducibles. Chapters in the book are: (1) Getting to Know George; (2) The Father and His Country; (3)…

78 FR 19632 - Special Local Regulations; St. Thomas Carnival Watersport Activities, Charlotte Amalie Harbor; St...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-02

...-AA08 Special Local Regulations; St. Thomas Carnival Watersport Activities, Charlotte Amalie Harbor; St... proposes to establish a special local regulation on the waters of Charlotte Amalie Harbor in St Thomas, USVI during the St. Thomas Carnival Watersport Activities, a high speed boat race. The event is...

Validation of the Hong Kong Chinese version of the St. George Respiratory Questionnaire in patients with bronchiectasis.

PubMed

Chan, Shelley L; Chan-Yeung, Moira M; Ooi, Gaik C; Lam, Cindy L; Cheung, Tung F; Lam, Wah K; Tsang, Kenneth W

2002-12-01

To validate the Hong Kong Chinese version of the St. George Respiratory Questionnaire (SGRQ-HK) in patients with bronchiectasis. Outpatients (93 patients; 61 women; mean age [+/- SD], 59.0 +/- 14.2 years) were assessed at baseline by the SGRQ-HK, the Hong Kong Chinese version of the 36-item short form health survey (SF-36-HK), and the hospital anxiety and depression scale (HADS). Forty randomly selected patients also were reassessed at 2 weeks for repeatability. Seventy-two patients were further reassessed at 6 months for responsiveness. Cronbach alpha coefficients, which reflected internal consistency, were > 0.7 for all SGRQ-HK components except for symptoms (alpha = 0.59), and the intraclass correlation coefficients between baseline and the 2-week follow-up visits were between 0.80 and 0.94 (p > 0.05). SGRQ-HK component scores and total scores correlated with all the component scores of the SF-36-HK and the HADS (p < 0.02). SGRQ-HK component scores and total scores correlated with the scores of the SF-36-HK and the HADS, confirming the concurrent validity. All SGRQ-HK scores correlated negatively with FEV(1), FVC, and arterial oxygen saturation (p < 0.005), while the activity score correlated with the Karnofsky performance scale and the number of bronchiectatic lobes (p < 0.001). SGRQ-HK scores positively correlated with Borg scale scores, exacerbation frequency, and 24-h sputum volumes (p < 0.03). Patients with 24-h sputum volumes of > or = 10 mL or < 10 mL had significantly different SQRG-HK component scores and total scores (p < 0.002), although this sensitivity was not displayed by scores on the HADS or the SF-36-HK. Patients with 25% reductions in 24-h sputum volumes had significant improvements in SGRQ-HK activity scores, impact scores, and total scores (p < 0.02), but not in other quality-of-life measures or clinical parameters, indicating the responsiveness of the SGRQ-HK. The SGRQ-HK is a valid and sensitive instrument for determining quality of life in

The botanical activities of George Edward Post (1838-1909).

PubMed

Musselman, Lytton John

2006-01-01

George Edward Post wrote the first flora of the Middle East in English. His other botanical activities are less familiar. In addition to the flora, this paper discusses his teaching, fieldwork, contribution to Bible dictionaries, relations with the Boissier Herbarium in Geneva, establishment of the herbarium, and letters. Those letters are used here for the first time. Post corresponded with botanical luminaries of his day including Autran, Baker, Balfour, Barbey, Boissier, Bornmüller, Carruthers, Denslow, Haussknecht, Hooker, Schweinfurth, Thistleton-Dyer, Torrey, and Winkler. His long-term relationship with the herbarium at Geneva is highlighted. In addition, some of the lesser understood aspects of his life including chaplaincy during the American Civil War, and missionary to Syria are discussed.

Astronaut George Nelson working on Comet Halley Active monitoring program

NASA Image and Video Library

1986-01-14

61C-05-026 (14 Jan. 1986) --- Astronaut George D. Nelson smiles for a fellow crew man's 35mm camera exposure while participating in the Comet Halley active monitoring program (CHAMP). Camera equipment and a protective shroud used to eliminate all cabin light interference surround the mission specialist. This is the first of three 1986 missions which are scheduled to monitor the rare visit by the comet. The principal investigators for CHAMP are S. Alan Stern of the Laboratory for Atmospheric and Space Physics at the University of Colorado; and Dr. Stephen Mende of Lockheed Palo Alto Research Laboratory.

MYD88 Inhibitor ST2825 Suppresses the Growth of Lymphoma and Leukaemia Cells.

PubMed

Shiratori, Erika; Itoh, Mai; Tohda, Shuji

2017-11-01

Myeloid differentiation primary response gene 88 (MYD88), which activates the nuclear factor kappa B (NF-κB) pathway, is important for the growth of lymphoma and leukaemia cells. In this study, we investigated the effects of ST2825, a synthetic peptidomimetic compound which inhibits MYD88 homodimerization, on their growth. Seven lymphoma and leukaemia cell lines including TMD8, a B-cell lymphoma line with MYD88-activating mutation, were treated with ST2825 and analysed for cell proliferation and expression of NF-κB signalling-related molecules. ST2825 suppressed the growth of all cell lines by inducing apoptosis and down-regulating phosphorylation of NF-κB pathway components inhibitor of nuclear factor kappa B kinase (IκB) and reticuloendotheliosis oncogene A (RelA), as well as of MYD88 activator Bruton tyrosine kinase (BTK), suggesting that MYD88 may affect BTK activity. ST2825 effects were specific as MYD88-targeting siRNA also suppressed phosphorylation of NF-κB signalling proteins and BTK in TMD8 cells. ST2825 may be a novel drug targeting not only B-lymphoid malignancies with MYD88 mutations, but also lymphoma and leukaemia with wild-type MYD88. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

173. WASHINGTON ST. ALEXANDRIA AND MEMORIAL FOR THE CONFEDERATE DEAD ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

173. WASHINGTON ST. ALEXANDRIA AND MEMORIAL FOR THE CONFEDERATE DEAD LOOKING NORTH. - George Washington Memorial Parkway, Along Potomac River from McLean to Mount Vernon, VA, Mount Vernon, Fairfax County, VA

Probable relationships between the lower Jurassic crocodilomorph trackways Batrachopus and Selenichus: Evidence and implications based on new finds from the St. George area southwestern Utah

USGS Publications Warehouse

Lockley, Martin G.; Kirkland, James I.; Milner, Andrew R.C.

2003-01-01

The enigmatic ichnogenus Selenichnus (Hitchcock, 1858) from the Lower Jurassic of Massachusetts and Utah may represent poorly preserved, extramorphological examples of Batrachopus. Selenichnus trackways from the St. George area (Utah) are virtually indistinguishable from the type material described by Hitchcock (1858) and Lull (1953) from Massachusetts. However, Selenichnus type specimens from Massachusetts, as well as the material from Utah, suggest a relationship with Batrachopus: The former track morphology appears to transform into the latter as preservational conditions change. The size and gait indicated by the two ichnogenera are similar. The suggested relationship between the two ichnogenera does not alter the fact that there are distinct differences in the morphology of the type specimens. Thus, pending discovery of more material, formal synonymy of the two ichnogenera is not formally proposed.

Georg Händel (1622-97): the barber-surgeon father of George Frideric Handel (1685-1759).

PubMed

Adams, Aileen K; Hofestädt, B

2005-08-01

George Frideric Handel was born in Halle (Saale) in Germany. After initial musical education in Germany and Italy, he came to London as a young man and spent the rest of his life in England. Until recently, little has been written of his early life in either the English or the German literature, and it is not widely known that he was the son of Georg Händel, a barber-surgeon of repute. When his father's name is mentioned, it is usually to claim that he actively discouraged his son's musical education. Georg Händel lived in a turbulent time; he became an eminent surgeon who served as valet and barber to the Courts of Saxony and Brandenburg, as well as a distinguished citizen of Halle. In describing his surgical duties, we show how these differed from those of barbers in England and France at that time. Barbers in Germany were less controlled, freer to practise as they pleased, and Händel himself had important duties in public health and forensic medicine. George Frideric was the first son of the second marriage, born when his father was 63 years of age. We aim also to dispel the notion that Händel's influence on his son's career was as obstructive as has been claimed, but rather that he was a responsible father with his children's interests at heart. This is shown in the success achieved by all his children, most of whom followed their father into medicine, while George Frideric became the most famous of them all, being regarded by posterity as one of the greatest composers.

The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis.

PubMed

Castillo, Ana F; Orlando, Ulises; Helfenberger, Katia E; Poderoso, Cecilia; Podesta, Ernesto J

2015-06-15

The steroidogenic acute regulatory (StAR) protein regulates the rate-limiting step in steroidogenesis, i.e. the delivery of cholesterol from the outer (OMM) to the inner (IMM) mitochondrial membrane. StAR is a 37-kDa protein with an N-terminal mitochondrial targeting sequence that is cleaved off during mitochondrial import to yield 30-kDa intramitochondrial StAR. StAR acts exclusively on the OMM and its activity is proportional to how long it remains on the OMM. However, the precise fashion and the molecular mechanism in which StAR remains on the OMM have not been elucidated yet. In this work we will discuss the role of mitochondrial fusion and StAR phosphorylation by the extracellular signal-regulated kinases 1/2 (ERK1/2) as part of the mechanism that regulates StAR retention on the OMM and activity. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

George Glasson and George Bogg's Prospects on the Environmental Friendly Relationship and Ecojustice

ERIC Educational Resources Information Center

Dopico, Eduardo

2011-01-01

This rejoinder to George Glasson and George Bogg's papers provides additional conversation for considering the idea that we try to develop: leaving the classroom to continue teaching. Converting the teaching-learning process into research experiences brings our students not only scientific knowledge, but also an understanding of the research…

Foraging segregation of two congeneric diving seabird species breeding on St. George Island, Bering Sea

NASA Astrophysics Data System (ADS)

Kokubun, Nobuo; Yamamoto, Takashi; Sato, Nobuhiko; Watanuki, Yutaka; Will, Alexis; Kitaysky, Alexander S.; Takahashi, Akinori

2016-04-01

Subarctic environmental changes are expected to affect the foraging ecology of marine top predators, but the response to such changes may vary among species if they use food resources differently. We examined the characteristics of foraging behavior of two sympatric congeneric diving seabird: common (Uria aalge: hereafter COMUs) and thick-billed (U. lomvia: hereafter TBMUs) murres breeding on St. George Island, located in the seasonal sea-ice region of the Bering Sea. We investigated their foraging trip and flight durations, diel patterns of dive depth, and underwater wing strokes, along with wing morphology and blood stable isotope signatures and stress hormones. Acceleration-temperature-depth loggers were attached to chick-guarding birds, and data were obtained from 7 COMUs and 12 TBMUs. Both species showed similar mean trip duration (13.2 h for COMUs and 10.5 h for TBMUs) and similar diurnal patterns of diving (frequent dives to various depths in the daytime and less frequent dives to shallow depths in the nighttime). During the daytime, the dive depths of COMUs had two peaks in shallow (18.1 m) and deep (74.2 m) depths, while those of TBMUs were 20.2 m and 59.7 m. COMUs showed more frequent wing strokes during the bottom phase of dives (1.90 s-1) than TBMUs (1.66 s-1). Fish occurred more frequently in the bill loads of COMUs (85 %) than those of TBMUs (56 %). The δ15N value of blood was significantly higher in COMUs (14.5 ‰) than in TBMUs (13.1 ‰). The relatively small wing area (0.053 m2) of COMUs compared to TBMUs (0.067 m2) may facilitate their increased agility while foraging and allow them to capture more mobile prey such as larger fishes that inhabit deeper depths. These differences in food resource use may lead to the differential responses of the two murre species to marine environmental changes in the Bering Sea.

A tribute to George Plafker

USGS Publications Warehouse

Fuis, Gary S.; Haeussler, Peter J.; Atwater, Brian F.

2015-01-01

In a long and distinguished career, George Plafker made fundamental advances in understanding of megathrust tectonics, tsunami generation, paleoseismology, crustal neotectonics, and Alaskan geology, chiefly by means of geological field observations. George discovered that giant earthquakes result from tens of meters of seismic slip on subduction megathrusts, and he did this before the theory of plate tectonics had become a paradigm. The discovery was founded on George's comprehensive mapping of land-level changes in the aftermath of the 1964 earthquake in Alaska, and on his follow-up mapping, in 1968, in the region of the 1960 earthquakes in Chile. The mapping showed paired, parallel belts of coseismic uplift largely offshore and coseismic subsidence mostly onshore – a pattern now familiar as the initial condition assumed in simulations of subduction-zone tsunamis. George recognized, moreover, that splay faulting can play a major role in tsunami generation, and he also distinguished carefully between tectonic and landslide sources for the multiple tsunamis that accounted for nearly all the fatalities associated with the 1964 Alaska earthquake. George's classic monographs on the 1964 earthquake include findings on subduction-zone paleoseismology that he soon extended to include stratigraphic evidence for cyclic vertical deformation at the Copper River Delta, as well as recurrent uplift evidenced by flights of marine terraces at Middleton Island. As a geologist of earthquakes, George also clarified the tectonics and hazards of crustal faulting in Alaska, California, and other areas worldwide. All the while, George was mapping bedrock geology in Alaska, where he contributed importantly to today's understanding of how terranes were accreted and modified. Especially important was his documentation of the origin, movement, subduction, and collision of the Yakutat terrane in southern Alaska.

General George C. Marshall

NASA Technical Reports Server (NTRS)

2004-01-01

This is a portrait of General George C. Marshall in Army uniform. The Marshall Space Flight Center, a NASA field installation, was established in Huntsville, Alabama, in 1960. The Center was named in honor of General George C. Marshall, the Army Chief of Staff during World War II, Secretary of State, and Nobel Prize Wirner for his world-renowned Marshall Plan.

George Chester Stone (1924-2013).

PubMed

Adler, Nancy

2014-01-01

George Chester Stone was born February 21, 1924, and died on July 13, 2013. A quiet revolutionary, George was a founder of the field of health psychology. George played critical roles conceptualizing the field of health psychology, charting its bounds and potential, promulgating guidelines for training, founding the first doctoral program in health psychology, editing influential volumes defining the new field, launching the flagship journal for the field, and establishing a home for the field within APA. He was able to accomplish all this through his talent for working collaboratively. 2014 APA, all rights reserved

EDITORIAL: George W Series Memorial Essays

NASA Astrophysics Data System (ADS)

Dodd, J. N.

1997-01-01

tuneable lasers, generally with the emphasis on understanding the underlying physics rather than accumulating data. He had a highly original mind, which showed both in his choice of research topics and in his method of approach. He did not follow fashion; his instinct for an interesting problem was at odds with the modem policy of direct funding and the identification of "growth areas". His applications for research grants were often unsuccessful, despite his high international standing and integrity. He was never interested in building up a large research team, and had comparatively few research students, but his enthusiasm and commitment to the quality of his science attracted a succession of overseas visitors to his laboratory. Following my own year at the Clarendon, and some subsequent visits both to Oxford and to Reading, there was a continuing strong association between the Clarendon and Otago Physics that continues until today. George Series was the William Evans Visiting Professor to Otago University in 1972. He never lost his interest in the fundamentals of physics inspired by his first researches into the structure of the hydrogen atom; he wrote on the Rydberg constant, the physics of spontaneous emission, and on the fine-structure constant α = e2/hc. He donated a garden seat to St Edmund Hall (Oxford), of which he was a Fellow. On it he placed a plaque* in recognition of the ubiquitous nature of this constant; it almost had magical significance for him. He served physics in many ways outside research. He was for a number of years the Editor of the European Journal of Physics and was also Editor of the Journal of Physics B: Atomic and Molecular Physics, He was also on the Editorial Board of a number of journals. He was elected to Fellowship of a number of physics societies. The Editorial Board of these Memorial Essays dedicate them to George's memory, and to his wife Annette and his family.

Role of BMI, airflow obstruction, St George's Respiratory Questionnaire and age index in prognostication of Asian COPD.

PubMed

Chan, Hiang Ping; Mukhopadhyay, Amartya; Chong, Pauline Lee Poh; Chin, Sally; Wong, Xue Yun; Ong, Venetia; Chan, Yiong Huak; Lim, Tow Keang; Phua, Jason

2017-01-01

COPD is a complex condition with a heavy burden of disease. Many multidimensional tools have been studied for their prognostic utility but none has been universally adopted as each has its own limitations. We hypothesize that a multidimensional tool examining four domains, health-related quality of life, disease severity, systemic effects of disease and patient factors, would better categorize and prognosticate these patients. We first evaluated 300 patients and found four factors that predicted mortality: BMI, airflow obstruction, St George's Respiratory Questionnaire and age (BOSA). A 10-point index (BOSA index) was constructed and prospectively validated in a cohort of 772 patients with all-cause mortality as the primary outcome. Patients were categorized into their respective BOSA quartile group based on their BOSA score. Multivariate survival analyses and receiver operator characteristic (ROC) curves were used to assess the BOSA index. Patients in BOSA Group 4 were at higher risk of death compared with their counterparts in Group 1 (hazard ratio (HR): 0.29, 95% CI: 0.16-0.51, P < 0.001) and Group 2 (HR: 0.53, 95% CI: 0.34-0.82, P = 0.005). Race and gender did not affect mortality. The area under the ROC curve for BOSA index was 0.690 ± 0.025 while that for Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2011 was 0.641 ± 0.025 (P = 0.17). The BOSA index predicts mortality well and it has at least similar prognostic utility as GOLD 2011 in Asian patients. The BOSA index is a simple tool that does not require complex equipment or testing. It has the potential to be used widely. © 2016 Asian Pacific Society of Respirology.

George Glasson and George Bogg's prospects on the environmental friendly relationship and ecojustice

NASA Astrophysics Data System (ADS)

Dopico, Eduardo

2011-06-01

This rejoinder to George Glasson and George Bogg's papers provides additional conversation for considering the idea that we try to develop: leaving the classroom to continue teaching. Converting the teaching-learning process into research experiences brings our students not only scientific knowledge, but also an understanding of the research procedures. To be involved in field work, students can connect more personally the local action with global issues. On the ground in which we operate, environmental science, teaching of knowledge is insufficient if not accompanied by ecological experiences where students can see and share the needs of environmental protection and the idea of sustainability. Both response authors tell us about their own experiences in research in this regard. In their essays we can appreciate the desire to investigate human activities on ecosystems. Reading it makes us look with passion and awareness at the different consequences for our ecological environments: if we develop environmentally consequential behavior or harmful lifestyles for the planet. Furthermore, they warn us of the need to follow the development of students learning and reflect on the ways in which it produces time-causal relationship between persons and the environment.

Publications - Plafker, George and others, 1994 | Alaska Division of

Science.gov Websites

Publications Plafker, George and others, 1994 main content USGS Plafker, George and others, 1994 Publication Details Title: Neotectonic map of Alaska Authors: Plafker, George, Gilpin, L.M., and Lahr, J.C Reference Plafker, George, Gilpin, L.M., and Lahr, J.C., 1994, Neotectonic map of Alaska, in Plafker, George

Famous Americans: George Washington and Abraham Lincoln.

ERIC Educational Resources Information Center

Fleming, Maria

This book provides background information and ideas for teaching about George Washington and Abraham Lincoln at the primary grade level. Cross-curricular activities include work in music, writing, art, research, plays, and games. A pull-out poster with a poem on "President's Day" is stapled in the center of the book. Chapters in the book…

76 FR 77208 - Affirmation of Vertical Datum for Surveying and Mapping Activities for the Islands of St. Croix...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-12

... Datum for Surveying and Mapping Activities for the Islands of St. Croix, St. John, and St. Thomas... datum for surveying and mapping activities for the islands of St. Croix, St. John, and St. Thomas of the... by other Federal surveying and mapping agencies on St. Croix, St. John, and St. Thomas, with the...

Active layer thermal monitoring at Fildes Peninsula, King George Island, Maritime Antarctica

NASA Astrophysics Data System (ADS)

Michel, Roberto; Schaefer, Carlos; Simas, Felipe; Pregesbauer, Michael; Bockheim, James

2013-04-01

International attention on the climate change phenomena has grown in the last decade, intense modelling of climate scenarios were carried out by scientific investigations searching the sources and trends of these changes. The cryosphere and its energy flux became the focus of many investigations, being recognised as a key element for the understanding of future trends. The active layer and permafrost are key components of the terrestrial cryosphere due to their role in energy flux regulation and high sensitivity to climate change (Kane et al., 2001; Smith and Brown, 2009). Compared with other regions of the globe, our understanding of Antarctic permafrost is poor, especially in relation to its thermal state and evolution, its physical properties, links to pedogenesis, hydrology, geomorphic dynamics and response to global change (Bockheim, 1995, Bockheim et al., 2008). The active layer monitoring site was installed in the summer of 2008, and consist of thermistors (accuracy ± 0.2 °C) arranged in a vertical array (Turbic Eutric Cryosol 600 m asl, 10.5 cm, 32.5 cm, 67.5 cm and 83.5 cm). King George Island experiences a cold moist maritime climate characterized by mean annual air temperatures of -2°C and mean summer air temperatures above 0°C for up to four months (Rakusa-Suszczewski et al., 1993, Wen et al., 1994). Ferron et al., (2004) found great variability when analysing data from 1947 to1995 and identified cycles of 5.3 years of colder conditions followed by 9.6 years of warmer conditions. All probes were connected to a Campbell Scientific CR 1000 data logger recording data at hourly intervals from March 1st 2008 until November 30th 2012. Meteorological data for Fildes was obtained from the near by stations. We calculated the thawing days, freezing days; thawing degree days and freezing degree days; all according to Guglielmin et al. (2008). The active lawyer thickness was calculated as the 0 °C depth by extrapolating the thermal gradient from the two

DiGeorge syndrome and unilateral symbrachydactyly.

PubMed

Devriendt, K; De Smet, L; De Boeck, K; Fryns, J P

1997-01-01

We describe a child with DiGeorge syndrome due to a del22(q11) and a symbrachydactyly of the left hand. The underlying cardiovascular malformations in DiGeorge syndrome may lead to an increased susceptibility to vascular disruptions, giving further support to the subclavian-artery-disruption-sequence theory.

EAARL topography: George Washington Birthplace National Monument

USGS Publications Warehouse

Brock, John C.; Wright, C. Wayne; Patterson, Matt; Nayegandhi, Amar; Patterson, Judd

2007-01-01

This Web site contains Lidar-derived topography (first return and bare earth) maps and GIS files for George Washington Birthplace National Monument in Virginia. These lidar-derived topography maps were produced as a collaborative effort between the U.S. Geological Survey (USGS) Coastal and Marine Geology Program, FISC St. Petersburg, the National Park Service (NPS), Northeast Coastal and Barrier Network, Inventory and Monitoring Program, and the National Aeronautics and Space Administration (NASA) Wallops Flight Facility. One objective of this research is to create techniques to survey coral reefs and barrier islands for the purposes of geomorphic change studies, habitat mapping, ecological monitoring, change detection, and event assessment. As part of this project, data from an innovative instrument under development at the NASA Wallops Flight Facility, the NASA Experimental Airborne Advanced Research Lidar (EAARL) are being used. This sensor has the potential to make significant contributions in this realm for measuring subaerial and submarine topography wthin cross-environment surveys. High spectral resolution, water-column correction, and low costs were found to be key factors in providing accurate and affordable imagery to coastal resource managers.

A 21st Century Library in a 20th Century Space

ERIC Educational Resources Information Center

Graboyes, Alanna S.

2012-01-01

The library at George C. Marshall High School in Fairfax County, Virginia, needed an update to better meet the needs of 21st century students. A major renovation was in the works, but head librarian Graboyes wanted to do something to make the library useful and appealing for current students. With careful budgeting and donations of time and money,…

The Development of the George B. Pegram Award

NASA Astrophysics Data System (ADS)

McCay, Myron S.

1997-11-01

The George B. Pegram Award for Excellence in the Teaching of Physics was developed by a representative group of SESAPS members over a period of eight years with outstanding contributions as follows: Jesse Beams, APS President, with the advice of Mark Zemansky, AAPT, chose George B. Pegram as the honoree, in view of his excellent teaching career at Columbia University, his graduation from Trinity College--now Duke University, his long period of service as Treasurer of APS, and his active support of the special training program at ORAU; Earle Plyler with the assistance of Edward Burke, Jr., prepared the selection criteria for the recipients of the award; Walter Gordy coordinated the APS approval and initiated the financing of the program; Howard Carr raised the first funds and prepared the initial certificates; William G. Pollard joined the committee and completed the early funding, while preparing the formal certificate and medal; Dr. Vernet Eaton, AAPT President, stimulated the program when he urged the nomination of SESAPS members for the Oersted Award. After his lectures at the 1955 Gainesville meeting, Wendell Holladay instructed the committee to report its recommendations at the next SESAPS meeting. In 1969 SESAPS approved the George B. Pegram Award.

Pre-Service Physics Teachers’ Perception toward Hands-on Lab Activity and 21st Century Skills

NASA Astrophysics Data System (ADS)

Putri, D. H.; Risdianto, E.; Sutarno, S.

2017-09-01

This study aimed to describe the hands-on lab activities and 21st century skills of pre-service physics teachers at a university in Bengkulu. The respondents of this study were 113 students who have been finished and were following the laboratory course. The research instrument was questionnaire. The explored aspects of laboratory activities were motivation, the importance of laboratory activities, equipment, laboratory activities process, suitability of curriculum, assessment, laboratory design, and the 21st century skills training. The 21st century skills explored consist of learning and innovation skills, life and careers skills, and media, information and technology skills. The data obtained will be analyzed descriptively. Based on the results of data analysis was obtained that they have a good perception toward the aspect of motivation, the importance of hands-on lab activities, and laboratory activities process; and the perception was fair for other aspects. The lowest perception score was obtained in the aspects of the 21st century skills training. This result was in accordance with the 21st century skills of pre-service physics teachers which were still in moderate category. So it is necessary to develop a model of laboratory activities design that can training and enhancing the 21st century skills for pre-service physics teachers.

Pseudothionin-St1, a potato peptide active against potato pathogens.

PubMed

Moreno, M; Segura, A; García-Olmedo, F

1994-07-01

A 5-kDa polypeptide, pseudothionin Solanum tuberosum 1 (Pth-St1), which was active against Clavibacter michiganensis subspecies sepedonicus, a bacterial pathogen of potatoes, has been purified from the buffer-insoluble fraction of potato tubers by salt extraction and HPCL. Pth-St1 was also active against other potato pathogens tested (Pseudomonas solanacearum and Fusarium solani). The N-terminal amino acid sequence of this peptide was identical (except for a N/H substitution at position 2) to that deduced from a previously reported cDNA sequence (EMBL accession number X-13180), which had been misclassified as a Browman-Birk protease inhibitor. Pth-St1 did not inhibit either trypsin or insect alpha-amylase activities, and, in contrast with true thionins, did not affect cell-free protein synthesis or beta-glucuronidase activity. Northern-blot and tissue-print analyses showed that steady-state mRNA levels were highest in flowers (especially in petals), followed by tubers (especially in the epidermal cell layers and in leaf primordia), stems and leaves. Infection of leaves with a bacterial pathogen suspended in 10 mM MgCl2 switched off the gene, whereas mock inoculation with 10 mM MgCl2 alone induced higher mRNA levels.

Active layer thermal monitoring at Fildes Peninsula, King George Island, Maritime Antarctica

NASA Astrophysics Data System (ADS)

Michel, R. F. M.; Schaefer, C. E. G. R.; Simas, F. N. B.; Francelino M., R.; Fernandes-Filho, E. I.; Lyra, G. B.; Bockheim, J. G.

2014-07-01

International attention to the climate change phenomena has grown in the last decade; the active layer and permafrost are of great importance in understanding processes and future trends due to their role in energy flux regulation. The objective of the this paper is to present active layer temperature data for one CALM-S site located at Fildes Peninsula, King George Island, Maritime Antarctica over an fifth seven month period (2008-2012). The monitoring site was installed during the summer of 2008 and consists of thermistors (accuracy of ± 0.2 °C), arranged vertically with probes at different depths, recording data at hourly intervals in a~high capacity data logger. A series of statistical analysis were performed to describe the soil temperature time series, including a linear fit in order to identify global trend and a series of autoregressive integrated moving average (ARIMA) models were tested in order to define the best fit for the data. The controls of weather on the thermal regime of the active layer have been identified, providing insights about the influence of climate chance over the permafrost. The active layer thermal regime in the studied period was typical of periglacial environment, with extreme variation at the surface during summer resulting in frequent freeze and thaw cycles. The active layer thickness (ALT) over the studied period showed variability related to different annual weather conditions, reaching a maximum of 117.5 cm in 2009. The ARIMA model was considered appropriate to treat the dataset, enabling more conclusive analysis and predictions when longer data sets are available. Despite the variability when comparing temperature readings and active layer thickness over the studied period, no warming trend was detected.

George Woodall, Ph.D.

EPA Pesticide Factsheets

Dr. George Woodall has over fifteen years of professional experience. This includes performing assessments of risk from exposure to air pollutants, assessing air quality, and managing research and technical projects.

Model Eliciting Activities: Fostering 21st Century Learners

ERIC Educational Resources Information Center

Stohlmann, Micah

2013-01-01

Real world mathematical modeling activities can develop needed and valuable 21st century skills. The knowledge and skills to become adept at mathematical modeling need to develop over time and students in the elementary grades should have experiences with mathematical modeling. For this to occur elementary teachers need to have positive…

Energy Storage: George Crabtree

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crabtree, George

2016-10-06

George Crabtree, Argonne scientist and Director of Joint Center for Energy Storage Research, discusses the importance of developing the next generation of batteries and how that could help transform the electricity grid.

Energy Storage: George Crabtree

ScienceCinema

Crabtree, George

2018-06-13

George Crabtree, Argonne scientist and Director of Joint Center for Energy Storage Research, discusses the importance of developing the next generation of batteries and how that could help transform the electricity grid.

The George Engelmann Mathematics & Science Institute. Scholar Research Program Annual Report 1993.

ERIC Educational Resources Information Center

Missouri Univ., St. Louis. George Englemann Mathematics & Science Inst.

This publication is a comprehensive report on the George Engelmann Mathematics and Science Institute's Scholar Research Program (SRP) and its activities in 1993. The SRP provides high school students who have successfully completed an earlier Engelmann program the opportunity to experience and practice the active components of the scientific…

Validity and reliability of the BOD POD® S/T tracking system.

PubMed

Tseh, W; Caputo, J L; Keefer, D J

2010-10-01

BOD POD(®) self-testing (S/T) body composition tracking system is a practical assessment tool designed for use in the health and fitness industries. Relative to its parent counterpart, the BOD POD(®) S/T has received little research attention. The primary purpose was to determine the validity of the BOD POD(®) S/T against hydrostatic weighing and 7-site skinfolds. Secondary aim was to determine the within-day and between-day reliability of the BOD POD(®) S/T. After a period of equipment and testing accommodation, volunteer's (N=50) body composition (%BF) via 7-site skinfolds, BOD POD(®) S/T, and hydrostatic weighing were obtained on the second and third visits. BOD POD(®) S/T significantly overestimated %BF when compared to hydrostatic weighing and 7-site skinfolds. There was no statistical difference between 7-site skinfolds and hydrostatic weighing values. BOD POD(®) S/T reliability within-day and between-days were high. While the BOD POD(®) S/T body composition tracking system is deemed reliable both within-day and between-days, it did significantly overestimate %BF in comparison to hydrostatic weighing and skinfolds. Future research should be aimed at deriving a correction factor for this body composition assessment tool. © Georg Thieme Verlag KG Stuttgart · New York.

The structural features of the sulfated heteropolysaccharide (ST-1) from Sargassum thunbergii and its neuroprotective activities.

PubMed

Jin, Weihua; Liu, Bing; Li, Shuai; Chen, Jing; Tang, Hong; Jiang, Di; Zhang, Quanbin; Zhong, Weihong

2018-03-01

Polysaccharide (ST) was prepared from Sargassum thunbergii using hot water. Two fractions (ST-1 and ST-2) were prepared using anion exchange chromatography. One desulfated polysaccharide (ST-1-DS) was also prepared. Electrospray ionization mass spectrometry (ESI-MS) performed on ST-1-DS showed that the desulfated polysaccharides contained methyl glycosides of mono-sulfated and di-sulfated galacto-fucooligosaccharides. This result suggested that ST-1 might contain sulfated galactofucan, which consists of a backbone of alternating (Gal) n and (Fuc) n and sulfated randomly on Gal and mainly on C-2 in Fuc. In addition, ST-1 was degraded in 1M sulfuric acid. The solution was centrifuged, and the supernatant was concentrated and precipitated in ethanol to obtain the precipitate (ST-1-P). ST-1-P was then separated using gel chromatography and anion exchange chromatography to obtain the oligomers. ESI-MS spectra of oligomers indicated that ST-1 mostly contained sulfated glucuronomannan and fucoglucuronan. ESI-MS with collision-induced dissociation tandem mass spectrometry (ESI-CID-MS/MS) suggested that glucuronomannan contained alternating 2-linked Man and 4-linked GlcA, while fucoglucuronan contained 4-linked glucuronan with branched Fuc at C-3. Finally, the neuroprotective activities of ST, ST-1, ST-2 and MIX (a mixture of ST-1 and ST-2) were determined. ST showed the most neuroprotective activity, which indicated that ST might be a good candidate for curing neurodegenerative diseases. Copyright © 2017 Elsevier B.V. All rights reserved.

Yura-George's world line

NASA Astrophysics Data System (ADS)

Gamov, I. L.

It is quite interesting and flattering for an economist to publish a paper in such a prominent astronomical journal. And taking into account the fact that the author is a relative of the great cosmologist of the 20th century does not diminish but, vice versa, increases the piquancy of the appearance of this article. You may agree, dear readers, that it is fairly difficult to avoid a temptation of addressing you on behalf of numerous admirers of George Gamow's talent, as well as of supporters of the Gamow Foundation of Moldova. Frankly speaking, I cannot get rid of a feeling that George Gamow himself, through some genetic "channels" known to him alone, is pushing me to tell about him, for he was famous for all kinds of tricks.

Georges Bank: a leaky incubator of Alexandrium fundyense blooms

PubMed Central

McGillicuddy, D.J.; Townsend, D.W.; Keafer, B.A.; Thomas, M.A.; Anderson, D.M.

2012-01-01

A series of oceanographic surveys on Georges Bank document variability of populations of the toxic dinoflagellate Alexandrium fundyense on time scales ranging from synoptic to seasonal to interannual. Blooms of A. fundyense on Georges Bank can reach concentrations on the order of 104 cells l−1, and are generally bank-wide in extent. Georges Bank populations of A. fundyense appear to be quasi-independent of those in the adjacent coastal Gulf of Maine, insofar as they occupy a hydrographic niche that is colder and saltier than their coastal counterparts. In contrast to coastal populations that rely on abundant resting cysts for bloom initiation, very few cysts are present in the sediments on Georges Bank. Bloom dynamics must therefore be largely controlled by the balance between growth and mortality processes, which are at present largely unknown for this population. Based on correlations between cell abundance and nutrient distributions, ammonium appears to be an important source of nitrogen for A. fundyense blooms on Georges Bank. PMID:24976691

Georges Bank: a leaky incubator of Alexandrium fundyense blooms.

PubMed

McGillicuddy, D J; Townsend, D W; Keafer, B A; Thomas, M A; Anderson, D M

2014-05-01

A series of oceanographic surveys on Georges Bank document variability of populations of the toxic dinoflagellate Alexandrium fundyense on time scales ranging from synoptic to seasonal to interannual. Blooms of A. fundyense on Georges Bank can reach concentrations on the order of 10 4 cells l -1 , and are generally bank-wide in extent. Georges Bank populations of A. fundyense appear to be quasi-independent of those in the adjacent coastal Gulf of Maine, insofar as they occupy a hydrographic niche that is colder and saltier than their coastal counterparts. In contrast to coastal populations that rely on abundant resting cysts for bloom initiation, very few cysts are present in the sediments on Georges Bank. Bloom dynamics must therefore be largely controlled by the balance between growth and mortality processes, which are at present largely unknown for this population. Based on correlations between cell abundance and nutrient distributions, ammonium appears to be an important source of nitrogen for A. fundyense blooms on Georges Bank.

Severe dystrophy in DiGeorge syndrome

PubMed Central

Rózsai, Barnabás; Kiss, Ákos; Csábi, Györgyi; Czakó, Márta; Decsi, Tamás

2009-01-01

We present the case history of a 3-year-old girl who was examined because of severe dystrophy. In the background, cow’s milk allergy was found, but her body weight was unchanged after eliminating milk from her diet. Other types of malabsorption were excluded. Based on nasal regurgitation and facial dysmorphisms, the possibility of DiGeorge syndrome was suspected and was confirmed by fluorescence in situ hybridization. The authors suggest a new feature associated with DiGeorge syndrome. PMID:19294771

Enhancement of collaboration activities utilizing 21st century learning design rubric

NASA Astrophysics Data System (ADS)

Cubero, Dave D.; Gargar, Clare V., Lady; Nallano, Gerlett Grace D.; Magsayo, Joy R.; Guarin, Rica Mae B.; Lahoylahoy, Myrna E.

2018-01-01

Twenty first century learners have incredibly diverse learning interests, needs, and aspirations. Engaging middle school students and sculpting successful, confident, and creative learners is a constant endeavor for educators [4]. In the 21st century classroom environments in which students can develop the skills they need in workplace. Collaboration occurs when students work together to create, discuss challenge and develop deeper critical thinking. In today's workplace, collaboration is essential as only few tasks are completed alone (Calgary and Park, 2016). The collaborative project-based curriculum used in this classroom develops the higher order thinking skills, effective communication skills, and knowledge of technology that students will need in the 21st century workplace. The study therefore aims to promote collaboration skills among learners as it is deemed as one of the top 21st century skills. Collaborative learning unleashes a unique intellectual and social synergy. This study aims to enhance the collaborative skills of students through conducting collaboration activities in learning the Ecosystem. This research utilizes pretest-posttest and employs descriptive research designs. It uses modified activities about the lesson on Ecosystem and utilizes a Collaboration Rubric to rate the modified activities. The activities were rated by ten In-Service teachers and there are 105 students who participated in doing the activities. The paired t-test is then used to analyze the data. The In-Service teachers evaluated the 1st and 2nd adapted activity and are rated as fair. Thus, the modified activities were enhanced since the ratings of each activity did not meet the criterion of the collaboration rubric. As for the 3rd adapted activity is rated as excellent and is ready for implementation. The evaluators provided comments and suggestions such as producing colored pictures on the activities, omitting some questions, and making the words simpler to enhance the

Three members of Medicago truncatula ST family (MtST4, MtST5 and MtST6) are specifically induced by hormones involved in biotic interactions.

PubMed

Albornos, Lucía; Martín, Ignacio; Hernández-Nistal, Josefina; Labrador, Emilia; Dopico, Berta

2018-06-01

In this work, we study the function of the Medicago truncatula ST4, ST5 and ST6 proteins that belong to a protein family of unknown function characterized by the DUF2775 domain. Thus, we analyse their promoter sequence and activity, their transcript accumulation, and their subcellular location. The analysis of the three promoters showed different combination of cis-acting regulatory elements and they presented different activity pattern. Throughout development only ST6 mRNAs have been detected in most of the stages analysed, while ST4 was faintly detected in the roots and in the flowers and ST5 was always absent. The addition of MeJA, ET and SA revealed specific responses of the STs, the ST4 transcript accumulation increased by MeJA; the ST5 by MeJA and ET when applied together; and the ST6 by ET and by SA. Finally, the ST4 and ST5 proteins were in the cell wall whereas the ST6 had a dual location. From these results, we can conclude that the ST4, ST5 and ST6 RNAs are specifically and differentially up-regulated by MeJA, ET and SA, plant regulators also involved in the plant defence, pointing that ST4, ST5 and ST6 proteins might be involved in specific biotic interactions through different signalling pathways. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Limb anomalies in DiGeorge and CHARGE syndromes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prasad, C.; Quackenbush, E.J.; Whiteman, D.

1997-01-20

Limb anomalies are not common in the DiGeorge or CHARGE syndromes. We describe limb anomalies in two children, one with DiGeorge and the other with CHARGE syndrome. Our first patient had a bifid left thumb, Tetralogy of Fallot, absent thymus, right facial palsy, and a reduced number of T-cells. A deletion of 22q11 was detected by fluorescence in situ hybridization (FISH). The second patient, with CHARGE syndrome, had asymmetric findings that included right fifth finger clinodactyly, camptodactyly, tibial hemimelia and dimpling, and severe club-foot. The expanded spectrum of the DiGeorge and CHARGE syndromes includes limb anomalies. 14 refs., 4 figs.

America's Hero to the World, George C. Marshall. Teacher's Guide. Second Edition [and] Resource Packet [and] George C. Marshall: An American Leader. A Teacher's Notebook.

ERIC Educational Resources Information Center

Thompson, Rachel Yarnell; Sittig, Linda H.

This teaching unit about George C. Marshall contains a teacher's guide, a resource packet, and a teacher's notebook. The teacher's guide includes ten introductory, overarching, and culminating activities: (1) About this Guide; (2) Getting to Know Him; (3) Marshal on Video; (4) Share a Space with a Hero; (5) On a Global Stage--Links; (6) A Picture…

Active-layer thermal monitoring on the Fildes Peninsula, King George Island, maritime Antarctica

NASA Astrophysics Data System (ADS)

Michel, R. F. M.; Schaefer, C. E. G. R.; Simas, F. M. B.; Francelino, M. R.; Fernandes-Filho, E. I.; Lyra, G. B.; Bockheim, J. G.

2014-12-01

International attention to climate change phenomena has grown in the last decade; the active layer and permafrost are of great importance in understanding processes and future trends due to their role in energy flux regulation. The objective of this paper is to present active-layer temperature data for one Circumpolar Active Layer Monitoring South hemisphere (CALM-S) site located on the Fildes Peninsula, King George Island, maritime Antarctica over an 57-month period (2008-2012). The monitoring site was installed during the summer of 2008 and consists of thermistors (accuracy of ±0.2 °C), arranged vertically with probes at different depths, recording data at hourly intervals in a high-capacity data logger. A series of statistical analyses was performed to describe the soil temperature time series, including a linear fit in order to identify global trends, and a series of autoregressive integrated moving average (ARIMA) models was tested in order to define the best fit for the data. The affects of weather on the thermal regime of the active layer have been identified, providing insights into the influence of climate change on permafrost. The active-layer thermal regime in the studied period was typical of periglacial environments, with extreme variation in surface during the summer resulting in frequent freeze and thaw cycles. The active-layer thickness (ALT) over the studied period shows a degree of variability related to different annual weather conditions, reaching a maximum of 117.5 cm in 2009. The ARIMA model could describe the data adequately and is an important tool for more conclusive analysis and predictions when longer data sets are available. Despite the variability when comparing temperature readings and ACT over the studied period, no trend can be identified.

Our Western Heritage: An Interview with Robert George

ERIC Educational Resources Information Center

Iannone, Carol

2012-01-01

This article presents an interview with Robert George, who holds Princeton's celebrated McCormick Chair in Jurisprudence and is the founding director of the James Madison Program. George has served on the President's Council on Bioethics and as a presidential appointee to the United States Commission on Civil Rights. He is also a member of the…

Fish based preimplantation genetic diagnosis to prevent DiGeorge syndrome.

PubMed

Shefi, Shai; Raviv, Gil; Rienstein, Shlomit; Barkai, Gad; Aviram-Goldring, Ayala; Levron, Jacob

2009-07-01

To report the performance of fluorescence in-situ hybridization in the setting of preimplantation genetic diagnosis in order to diagnose embryos affected by DiGeorge syndrome. Case report. Academic referral center. A 32 year-old female affected by DiGeorge syndrome. History and physical examination, karyotyping, amniocentesis, preimplantation genetic diagnosis, fluorescence in-situ hybridization. Avoidance of pregnancy with embryo affected by DiGeorge syndrome. Termination of pregnancy with an affected embryo followed by fluorescence in-situ hybridization based preimplantation genetic diagnosis and delivery of healthy offspring. The combination of preimplantation genetic diagnosis with fluorescence in-situ hybridization is recommended to prevent pregnancies with DiGeorge syndrome affected embryos in properly selected patients.

Foraging segregation of two congeneric diving seabird species (common and thick-billed murres) breeding on St. George Island, Bering Sea

NASA Astrophysics Data System (ADS)

Kokubun, N.; Yamamoto, T.,; Sato, N.; Watanuki, Y.; Will, A.; Kitaysky, A. S.; Takahashi, A.

2015-11-01

Sub-arctic environmental changes are expected to affect the ecology of marine top predators. We examined the characteristics of foraging behavior of two sympatric congeneric diving seabirds, common (Uria aalge: hereafter COMU) and thick-billed (U. lomvia: hereafter TBMU) murres breeding on St. George Island located in the seasonal sea-ice region of the Bering Sea. We investigated their flight duration, diel patterns of dive depth, and underwater wing strokes, along with morphology and blood stable isotopes. Acceleration-temperature-depth data loggers were attached to chick-guarding birds, and behavioral data were obtained from 7 COMU and 12 TBMU. Both species showed similar trip duration (13.21 ± 4.79 h for COMU and 10.45 ± 7.09 h for TBMU) and similar diurnal patterns of diving (frequent dives to various depths in the daytime and less frequent dives to shallow depths in the nighttime). During the daytime, dive depths of COMU had two peaks in shallow (18.1 ± 6.0 m) and deep (74.2 ± 8.7 m) depths, while those of TBMU were 20.2 ± 7.4 m and 59.7 ± 7.9 m. COMU showed more frequent wing strokes during the bottom phase of dives (1.90 ± 0.11 s-1) than TBMU (1.66 ± 0.15 s-1). Fishes occurred with higher proportion in the bill-loads brought back to chicks in COMU (85 %) than in TBMU (56 %). δ15N value of blood was significantly higher in COMU (14.47 ± 0.27 ‰) than in TBMU (13.14 ± 0.36 ‰). Relatively small wing area (0.053 ± 0.007 m2) of COMU compared to TBMU (0.067 ± 0.007 m2) may make them more agile underwater and thus enable them to target more mobile prey including larger fishes that inhabit deeper depths. These differences in foraging behavior between COMU and TBMU might explain the differences in their responses to long-term marine environmental changes.

Upper limb malformations in DiGeorge syndrome

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cormier-Daire, V.; Iserin, L.; Sidi, D.

1995-03-13

We report on upper limb anomalies in two children with a complete DiGeorge sequence: conotruncal defects, hypocalcemia, thymic aplasia, and facial anomalies. One child had preaxial polydactyly, and the other had club hands with hypoplastic first metacarpal. In both patients, molecular analysis documented a 22q11 deletion. To our knowledge, limb anomalies have rarely been reported in DiGeorge syndrome, and they illustrate the variable clinical expression of chromosome 22q11 deletions. 13 refs., 2 figs.

01-NIF Dedication: George Miller

ScienceCinema

George Miller

2017-12-09

The National Ignition Facility, the world's largest laser system, was dedicated at a ceremony on May 29, 2009 at Lawrence Livermore National Laboratory. These are the remarks by Lab Director George Miller.

01-NIF Dedication: George Miller

DOE Office of Scientific and Technical Information (OSTI.GOV)

George Miller

2009-07-02

The National Ignition Facility, the world's largest laser system, was dedicated at a ceremony on May 29, 2009 at Lawrence Livermore National Laboratory. These are the remarks by Lab Director George Miller.

George Andrew Olah - Patents

Science.gov Websites

Additional Information US 4,394,247 LIQUEFACTION OF COALS USING RECYCLABLE SUPERACID CATALYST - Olah, George catalytic condensation using superacid catalysts. US 4,465,893 OXIDATIVE CONDENSATION OF NATURAL GAS OR ., synthetic transportation fuels or lower olefins) via catalytic condensation using superacid catalysts. US

General George C. Marshall

NASA Technical Reports Server (NTRS)

2004-01-01

The Marshall Space Flight Center, a NASA field installation, was established at Huntsville, Alabama, in 1960. The Center was named in honor of General George C. Marshall, the Army Chief of Staff during World War II, Secretary of State, and Nobel Prize Wirner for his world-renowned Marshall Plan.

The novel Solanum tuberosum calcium dependent protein kinase, StCDPK3, is expressed in actively growing organs.

PubMed

Grandellis, Carolina; Giammaria, Verónica; Bialer, Magalí; Santin, Franco; Lin, Tian; Hannapel, David J; Ulloa, Rita M

2012-12-01

Calcium-dependent protein kinases (CDPKs) are key components of calcium regulated signaling cascades in plants. In this work, isoform StCDPK3 from Solanum tuberosum was studied and fully described. StCDPK3 encodes a 63 kDa protein with an N-terminal variable domain (NTV), rich in prolines and glutamines, which presents myristoylation and palmitoylation consensus sites and a PEST sequence indicative of rapid protein degradation. StCDPK3 gene (circa 11 kb) is localized in chromosome 3, shares the eight exons and seven introns structure with other isoforms from subgroup IIa and contains an additional intron in the 5'UTR region. StCDPK3 expression is ubiquitous being transcripts more abundant in early elongating stolons (ES), leaves and roots, however isoform specific antibodies only detected the protein in leaf particulate extracts. The recombinant 6xHis-StCDPK3 is an active kinase that differs in its kinetic parameters and calcium requirements from StCDPK1 and 2 isoforms. In vitro, StCDPK3 undergoes autophosphorylation regardless of the addition of calcium. The StCDPK3 promoter region (circa 1,800 bp) was subcloned by genome walking and fused to GUS. Light and ABRE responsive elements were identified in the promoter region as well as elements associated to expression in roots. StCDPK3 expression was enhanced by ABA while GA decreased it. Potato transgenic lines harboring StCDPK3 promoter∷GUS construct were generated by Agrobacterium tumefaciens mediated plant transformation. Promoter activity was detected in leaves, root tips and branching points, early ES, tuber eyes and developing sprouts indicating that StCDPK3 is expressed in actively growing organs.

Amylases StAmy23, StBAM1 and StBAM9 regulate cold-induced sweetening of potato tubers in distinct ways

PubMed Central

Hou, Juan; Zhang, Huiling; Liu, Jun; Reid, Stephen; Liu, Tengfei; Xu, Shijing; Tian, Zhendong; Sonnewald, Uwe

2017-01-01

Abstract Cold-induced sweetening (CIS) in potato is detrimental to the quality of processed products. Conversion of starch to reducing sugars (RS) by amylases is considered one of the main pathways in CIS but is not well studied. The amylase genes StAmy23, StBAM1, and StBAM9 were studied for their functions in potato CIS. StAmy23 is localized in the cytoplasm, whereas StBAM1 and StBAM9 are targeted to the plastid stroma and starch granules, respectively. Genetic transformation of these amylases in potatoes by RNA interference showed that β-amylase activity could be decreased in cold-stored tubers by silencing of StBAM1 and collective silencing of StBAM1 and StBAM9. However, StBAM9 silencing did not decrease β-amylase activity. Silencing StBAM1 and StBAM9 caused starch accumulation and lower RS, which was more evident in simultaneously silenced lines, suggesting functional redundancy. Soluble starch content increased in RNAi-StBAM1 lines but decreased in RNAi-StBAM9 lines, suggesting that StBAM1 may regulate CIS by hydrolysing soluble starch and StBAM9 by directly acting on starch granules. Moreover, StBAM9 interacted with StBAM1 on the starch granules. StAmy23 silencing resulted in higher phytoglycogen and lower RS accumulation in cold-stored tubers, implying that StAmy23 regulates CIS by degrading cytosolic phytoglycogen. Our findings suggest that StAmy23, StBAM1, and StBAM9 function in potato CIS with varying levels of impact. PMID:28369567

View of inside second floor stairwell of George Washington Junior ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View of inside second floor stairwell of George Washington Junior High School looking at double doors, facing north. - George Washington Junior High School, 707 Columbus Drive, Tampa, Hillsborough County, FL

75 FR 80471 - Takes of Marine Mammals Incidental to Specified Activities; St. George Reef Light Station...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-22

... maintenance activities. SGRLPS proposes to transport visitors to the Station during the Sunday work window... two times per year within the proposed work window. Scheduled light maintenance activities would... light. For each emergency repair event, the SGRLPS proposes to conduct a maximum of four flights (two...

Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death.

PubMed

Britain, Colleen M; Holdbrooks, Andrew T; Anderson, Joshua C; Willey, Christopher D; Bellis, Susan L

2018-02-05

The ST6Gal-I sialyltransferase is upregulated in numerous cancers, and high expression of this enzyme correlates with poor patient prognosis in various malignancies, including ovarian cancer. Through its sialylation of a select cohort of cell surface receptors, ST6Gal-I modulates cell signaling to promote tumor cell survival. The goal of the present study was to investigate the influence of ST6Gal-I on another important receptor that controls cancer cell behavior, EGFR. Additionally, the effect of ST6Gal-I on cancer cells treated with the common EGFR inhibitor, gefitinib, was evaluated. Using the OV4 ovarian cancer cell line, which lacks endogenous ST6Gal-I expression, a kinomics assay revealed that cells with forced overexpression of ST6Gal-I exhibited increased global tyrosine kinase activity, a finding confirmed by immunoblotting whole cell lysates with an anti-phosphotyrosine antibody. Interestingly, the kinomics assay suggested that one of the most highly activated tyrosine kinases in ST6Gal-I-overexpressing OV4 cells was EGFR. Based on these findings, additional analyses were performed to investigate the effect of ST6Gal-I on EGFR activation. To this end, we utilized, in addition to OV4 cells, the SKOV3 ovarian cancer cell line, engineered with both ST6Gal-I overexpression and knockdown, as well as the BxPC3 pancreatic cancer cell line with knockdown of ST6Gal-I. In all three cell lines, we determined that EGFR is a substrate of ST6Gal-I, and that the sialylation status of EGFR directly correlates with ST6Gal-I expression. Cells with differential ST6Gal-I expression were subsequently evaluated for EGFR tyrosine phosphorylation. Cells with high ST6Gal-I expression were found to have elevated levels of basal and EGF-induced EGFR activation. Conversely, knockdown of ST6Gal-I greatly attenuated EGFR activation, both basally and post EGF treatment. Finally, to illustrate the functional importance of ST6Gal-I in regulating EGFR-dependent survival, cells were

Geophysical fingerprints of shallow cultural structures from microgravity and GPR measurements in the Church of St. George, Svätý Jur, Slovakia

NASA Astrophysics Data System (ADS)

Panisova, Jaroslava; Murín, Igor; Pašteka, Roman; Haličková, Jana; Brunčák, Peter; Pohánka, Vladimír; Papčo, Juraj; Milo, Peter

2016-04-01

Recording of the historic edifice using the state-of-the-art geodetic and geophysical techniques brings easier visualisation in form of a three-dimensional (3D) model, thus allowing better understanding of its historical construction by the public and non-experts. We have applied this approach at the Church of St. George, one of the most significant religious buildings in south-western Slovakia, which dominates a silhouette of the town Svätý Jur. The geodetic survey allowed to record the actual state of the church. The church exterior was surveyed using a total station. Due to the intricate shape of the interior components of the church, it was decided to use a terrestrial laser scanner to generate the point cloud data, which were processed into floor plan, elevations, sectional 2D drawings and 3D model. The geophysical survey was carried out in the interior of the church in order to identify potential subsurface anthropogenic structures. Microgravity and ground penetrating radar (GPR) methods were selected as the most effective geophysical tools for such task. In microgravity data processing we focused on the calculation and removal of the gravitational effects of the building masses. The main negative gravity anomalies of interest in the nave, which also have been confirmed by GPR measurements, are interpreted as medieval crypts. Another very important outcome of the geophysical survey is the discovery of the west wall foundations of the oldest Romanesque construction. From each geophysical data acquired we derived 3D polygonal models, which are compared to achieve more realistic picture of the subsurface structures. Verification of these structures by means of archaeological excavation has not been carried out yet.

Connecting to Curious George

ERIC Educational Resources Information Center

Hinshaw, Craig

2006-01-01

Each month throughout the school year, two second grade teachers at Lessenger Elementary highlight a different children's author. The interdisciplinary lessons that evolved the month they selected Margaret and H.A. Rey's Curious George books were the most successful. In this article, the author relates how art, story writing, reading aloud, and…

Interleukin-33/ST2 axis promotes epithelial cell transformation and breast tumorigenesis via upregulation of COT activity.

PubMed

Kim, J Y; Lim, S-C; Kim, G; Yun, H J; Ahn, S-G; Choi, H S

2015-09-17

Cytokines of the interleukin-1 (IL-1) family, such as IL-1α/β and IL-18, have pleiotropic activities in innate and adaptive immune responses in host defense and diseases. Insight into their biological functions helped develop novel therapeutic approaches to treat human inflammatory diseases. IL-33 is an important member of the IL-1 family of cytokines and is a ligand of the ST2 receptor, a member of the IL-1 receptor family. However, the role of the IL-33/ST2 axis in tumor growth and metastasis of breast cancer remains unclear. Here, we demonstrate that IL-33 is a critical tumor promoter during epithelial cell proliferation and tumorigenesis in the breast. IL-33 dose- and time-dependently increased Cancer Osaka Thyroid (COT) phosphorylation via ST2-COT interaction in normal epithelial and breast cancer cells. The IL-33/ST2/COT cascade induced the activation of the MEK-ERK (MEK-extracellular signal-regulated kinase), JNK-cJun (cJun N-terminal kinase-cJun) and STAT3 (signal transducer and activator of transcription 3) signaling pathways, followed by increased AP-1 and stat3 transcriptional activity. When small interfering RNAs of ST2 and COT were introduced into cells, IL-33-induced AP-1 and stat3 activity were significantly decreased, unlike that in the control cells. The inhibition of COT activity resulted in decreased IL-33-induced epithelial cell transformation, and knockdown of IL-33, ST2 and COT in breast cancer cells attenuated tumorigenicity of breast cancer cells. Consistent with these observations, ST2 levels were positively correlated with COT expression in human breast cancer. These findings provide a novel perspective on the role of the IL-33/ST2/COT signaling pathway in supporting cancer-associated inflammation in the tumor microenvironment. Therapeutic approaches that target this pathway may, therefore, effectively inhibit carcinogenesis in the breast.

Who Framed George Lakoff?

ERIC Educational Resources Information Center

Goldstein, Evan R.

2008-01-01

In this article, a noted linguist reflects on his tumultuous foray into politics. For years George P. Lakoff has been at the center of some of the biggest intellectual disagreements in linguistics (most famously with Noam Chomsky) and has helped create an important interdisciplinary field of study, cognitive linguistics, that is reshaping people's…

George Sigerson: Charcot's translator.

PubMed

Lyons, J B

1997-04-01

Senator George Sigerson (1836-1925), Dublin's first neurologist, was also a significant contributor to Anglo-Irish literature. His medical career and literary accomplishments are outlined, the focus of the article being Sigerson's friendly relationship with Charcot (with whom he corresponded), and whose Leçons sur les maladies du système nerveux he translated.

The George Engelmann Mathematics & Science Institute. 1993 Annual Report Science Scholar Program.

ERIC Educational Resources Information Center

Missouri Univ., St. Louis. George Englemann Mathematics & Science Inst.

This publication is a comprehensive report on the George Engelmann Mathematics and Science Institute's Science Scholar program (SSP) and its activities in 1993. The SSP provides high achieving high school students an introductory, 4-week summer curriculum designed to demonstrate the connecting thread running through all scientific thought. The 52…

Baker & Taylor's George Coe

ERIC Educational Resources Information Center

Fialkoff, Francine

2009-01-01

In his 30 years as a library wholesaler, first as VP and general manager of Brodart Books, Library, and School Automation divisions and since 2000 as president of the Library & Education division of Baker & Taylor (B&T), George Coe has been instrumental in a whole host of innovations. They go way beyond the selection, processing, and delivery of…

George Saintbury's View of Rhetoric

ERIC Educational Resources Information Center

Hostettler, Gordon F.

1977-01-01

Investigates the career of George Edward Bateman Saintsbury (1845-1933), the eighth Regius Professor at the University of Edinburgh. Outlines his position as a literary critic, reviews and analyzes his views of rhetoric and rhetoricians, and offers assessments of his views. (MH)

George O. White State Park Forest Nursery - Licking, Missouri

Treesearch

Greg Hoss

2002-01-01

The George O. White State Forest Nursery is owned and operated by the Missouri Department of Conservation. Our agency is responsible for the management of the fish, forest, and wildlife resources of the state.This paper will address the George O. White State Forest Nursery. It will discuss where we are, a little of our history, and our growing...

Revision Surgery in Permanent Patellar Dislocation in DiGeorge Syndrome

PubMed Central

Berruto, Massimo; Parente, Andrea; Ferrua, Paolo; Pasqualotto, Stefano; Uboldi, Francesco; Usellini, Eva

2015-01-01

A 29-year-old patient, suffering from DiGeorge syndrome, came to our attention with a history of persistent pain and patellar instability in the left knee after failure of arthroscopic lateral release and Elmslie-Trillat procedure. The patient was unable to walk without crutches and severely limited in daily living activities. Because of arthritic changes of the patellofemoral joint and the failure of previous surgeries it was decided to perform only an open lateral release and medial patellofemoral ligament (MPFL) reconstruction using a biosynthetic ligament in order to obtain patellofemoral stability. At one year post-op range of motion (ROM) was 0–120 with a firm end point at medial patellar mobilization; patella was stable throughout the entire ROM. All the scores improved and she could be able to perform daily activity without sensation of instability. Bilateral patellar subluxation and systemic hyperlaxity are characteristics of syndromic patients and according to literature can be also present in DiGeorge syndrome. MPFL reconstruction with lateral release was demonstrated to be the correct solution in the treatment of patellar instability in this complex case. The choice of an artificial ligament to reconstruct the MPFL was useful in this specific patient with important tissue laxity due to her congenital syndrome. PMID:26783479

Interdecadal heterogeneity in mitochondrial DNA of Atlantic haddock (Melanogrammus aeglefinus) from Georges Bank.

PubMed

Purcell, M K; Kornfield, I; Fogarty, M; Parker, A

1996-09-01

Atlantic haddock of Georges Bank are characterized by large fluctuations in population size and a recent collapse of the commercial fishery. DNA extracted from dried scales of Georges Bank haddock, archived by the U.S. National Marine Fisheries Service (NMFS), reveals significant heterogeneity in frequencies of four mitochondrial DNA control region haplotypes between 1975 and 1985 cohorts. Several processes may be responsible for this temporal variation, the most attractive hypothesis being that haddock from other geographic regions episodically contribute to the Georges Bank gene pool. Thus, the population of haddock spawning on Georges Bank may not be genetically discrete and, with respect to Atlantic haddock, Georges Bank may not be viewed as a closed system.

Social Justice, Competition and Quality: 21st Century Leadership Challenges. The 2012 Yearbook of the National Council of Professors of Educational Administration

ERIC Educational Resources Information Center

Perreault, George, Ed.; Zellner, Luana, Ed.

2012-01-01

This is the 2012 Yearbook of the National Council of Professors of Educational Administration (NCPEA). This Yearbook contains the following papers: (1) Editors' Sidebar (George Perreault and Luana Zellner); (2) The Hour Glass Economy: The Social Justice Challenge for the 21st Century (Fenwick W. English); (3) Maintaining the Human Touch in…

Image Sciences Division activities in bldg 8 and 424 for presentation

NASA Image and Video Library

1994-01-25

Views of Image Sciences Division activities in bldg 8 and 424 for use in presentation by George Abbey, Deputy Center Director. Views include Taft Broadcasting employee Dexter Herbert in television editing suite in bldg 8 (26624); RMS Photographic Services employee Kelly St. Germaine at IAMS viewing station in the lobby of bldg 8 (26625); RMS employee Irene Jenkins standing in front of automated files used for negative storage in bldg 424 (26626); RMS employee Irma Rodriguez at barcoding and checkout station in bldg 424 (26627).

Electrocardiograhic findings resulting in inappropriate cardiac catheterization laboratory activation for ST-segment elevation myocardial infarction

PubMed Central

Shamim, Shariq; McCrary, Justin; Wayne, Lori; Gratton, Matthew

2014-01-01

Background Prompt reperfusion has been shown to improve outcomes in patients with acute ST-segment elevation myocardial infarction (STEMI) with a goal of culprit vessel patency in <90 minutes. This requires a coordinated approach between the emergency medical services (EMS), emergency department (ED) and interventional cardiology. The urgency of this process can contribute to inappropriate cardiac catheterization laboratory (CCL) activations. Objectives One of the major determinants of inappropriate activations has been misinterpretation of the electrocardiogram (ECG) in the patient with acute chest pain. Methods We report the ECG findings for all CCL activations over an 18-month period after the inception of a STEMI program at our institution. Results There were a total of 139 activations with 77 having a STEMI diagnosis confirmed and 62 activations where there was no STEMI. The inappropriate activations resulted from a combination of atypical symptoms and misinterpretation of the ECG (45% due to anterior ST-segment elevation) on patient presentation. The electrocardiographic abnormalities were particularly problematic in African-Americans with left ventricular hypertrophy. Conclusions In this single-center, prospective observational study, nearly half of the inappropriate STEMI activations were due to the misinterpretation of anterior ST-segment elevation and this finding was commonly seen in African-Americans with left ventricular hypertrophy. PMID:25009790

Obituary: George Hamilton Bowen Jr. (1925-2009)

NASA Astrophysics Data System (ADS)

Willson, Lee Anne; Struck, Curtis

2011-12-01

Our colleague and collaborator George Hamilton Bowen, Jr., passed away November 1, 2009 in Ames, Iowa. George was born June 20, 1925 in Tulsa, Oklahoma to George and Dorothy (Huntington) Bowen. He married Marjorie Brown June 19, 1948 in Redondo Beach, California; they had five children, with eight grandchildren and five great-grandchildren at the time of his death. George H. Bowen's third or perhaps his fourth career was in astronomy. He was drafted into the navy in 1944, at the end of his first year as a student at Caltech, and ended his war-time service as an electronic technician on the aircraft carrier Shangri-La. He later said "In just nine months, starting from scratch (Ohm's law!), we learned an amazing amount - not by memorization, of course, but by study and real understanding of the basic function of the most advanced AC circuits then being used for instrumentation, measurements, communications, control systems, and much more." He gained a confidence that he could quickly and accurately diagnose and solve technical problems that stood him well in future work. One accomplishment he took particular pride in was figuring out how the radar control used cams and gears to solve the trigonometry for accurate pointing. He also described how the captain was alarmed when weather conditions changed so that refraction no longer showed them distant, small boats around the curvature of Earth. After the war, George Bowen returned to undergraduate and eventually graduate study at Caltech, where he was recruited to the biophysics research group headed by future Nobel Laureate Max Delbrück. George often described his joy in working with these first-rate scientists and finding himself accepted as a part of the effort. He finished his BS with honors in 1949 and his PhD in 1953 with a thesis on "Kinetic Studies on the Mechanism of Photoreactivation of Bacteriophase T2 Inactivated by Ultraviolet Light" involving work with E Coli. This work was supported by grants from the U

Association of Single Nucleotide Polymorphisms in the ST3GAL4 Gene with VWF Antigen and Factor VIII Activity.

PubMed

Song, Jaewoo; Xue, Cheng; Preisser, John S; Cramer, Drake W; Houck, Katie L; Liu, Guo; Folsom, Aaron R; Couper, David; Yu, Fuli; Dong, Jing-Fei

2016-01-01

VWF is extensively glycosylated with biantennary core fucosylated glycans. Most N-linked and O-linked glycans on VWF are sialylated. FVIII is also glycosylated, with a glycan structure similar to that of VWF. ST3GAL sialyltransferases catalyze the transfer of sialic acids in the α2,3 linkage to termini of N- and O-glycans. This sialic acid modification is critical for VWF synthesis and activity. We analyzed genetic and phenotypic data from the Atherosclerosis Risk in Communities (ARIC) study for the association of single nucleotide polymorphisms (SNPs) in the ST3GAL4 gene with plasma VWF levels and FVIII activity in 12,117 subjects. We also analyzed ST3GAL4 SNPs found in 2,535 subjects of 26 ethnicities from the 1000 Genomes (1000G) project for ethnic diversity, SNP imputation, and ST3GAL4 haplotypes. We identified 14 and 1,714 ST3GAL4 variants in the ARIC GWAS and 1000G databases respectively, with 46% being ethnically diverse in their allele frequencies. Among the 14 ST3GAL4 SNPs found in ARIC GWAS, the intronic rs2186717, rs7928391, and rs11220465 were associated with VWF levels and with FVIII activity after adjustment for age, BMI, hypertension, diabetes, ever-smoking status, and ABO. This study illustrates the power of next-generation sequencing in the discovery of new genetic variants and a significant ethnic diversity in the ST3GAL4 gene. We discuss potential mechanisms through which these intronic SNPs regulate ST3GAL4 biosynthesis and the activity that affects VWF and FVIII.

Pantheon of Philanthropy: George Peabody.

ERIC Educational Resources Information Center

Parker, Franklin

1994-01-01

One in a collection of papers on George Peabody, educational philanthropist, discusses the history of his philanthropy. The paper looks at Peabody's life, death, and unusual funeral, his fortune, the first institute (born out of the Peabody Education Fund), the division of the fund, and Peabody's international planning dinners. (SM)

Antitumor activity of the synthetic retinoid ST1926 on primary effusion lymphoma in vitro and in vivo models.

PubMed

Karam, Louna; Houshaymi, Bilal; Abdel-Samad, Rana; Jaafar, Mariam; Halloum, Iman; Pisano, Claudio; Neipel, Frank; Darwiche, Nadine; Abou Merhi, Raghida

2018-02-01

Primary effusion lymphoma (PEL) is a rare B-cell neoplasm, associated with Kaposi sarcoma-associated herpes virus/human herpes virus-8 (KSHV/HHV-8), arising as malignant effusions in body cavities. PEL cells do not harbor conventional genetic cancer mutations; however, their oncogenesis is mainly attributed to HHV-8 latent genes. Treatment strategies are inefficient resulting in poor prognosis of PEL patients, stressing the need for new effective therapy. ST1926 is a synthetic retinoid with favorable antitumor properties and no cross-resistance with the natural retinoid, all-trans retinoic acid. ST1926 has shown potent apoptotic activities on a variety of solid tumors and hematologic malignancies in in vitro and in vivo models. In the present study we elucidated the antitumor activities and underlying molecular mechanism of ST1926 using in vitro, ex vivo, and in vivo PEL preclinical models. ST1926, at sub‑micromolar concentrations, displayed potent antiproliferative effects on PEL cell lines and malignant ascites. Furthermore, ST1926 treatment of PEL cells and ascites resulted in their accumulation in the sub-G1 region, S phase cell cycle arrest, early DNA damage, PARP cleavage and p53 activation including the upregulation of its target genes p21 and Bax. However, ST1926 did not significantly modulate HHV-8 latent viral transcripts. Importantly, ST1926 delayed formation of ascites and enhanced survival of PEL mice. These results highlight the therapeutic potential of ST1926 in combination with drugs that target HHV-8 in PEL patients.

33 CFR 334.520 - Lake George, Fla.; naval bombing area.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Lake George, Fla.; naval bombing....; naval bombing area. (a) The danger zone. An area in the eastern part of Lake George described as follows.... (2) Prior to each bombing operation the danger zone will be patrolled by naval aircraft which will...

33 CFR 334.520 - Lake George, Fla.; naval bombing area.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Lake George, Fla.; naval bombing....; naval bombing area. (a) The danger zone. An area in the eastern part of Lake George described as follows.... (2) Prior to each bombing operation the danger zone will be patrolled by naval aircraft which will...

George Morrison: Anishinaabe Expressionist Artist

ERIC Educational Resources Information Center

Vizenor, Gerald

2006-01-01

In this article, the author discusses the life and works of an Anishinaabe expressionist artist George Morrison. Morrison was an eminent expressionist painter with a singular romantic vision and an erudite sense of natural reason and liberty. He created an elusive shimmer of "endless space," the color and eternal motion of nature. The…

Effects of sodium dodecyl sulfate on the conformation and hemolytic activity of St I and St II, two isotoxins purified from Stichodactyla helianthus.

PubMed

Lanio, M E; Alvarez, C; Pazos, F; Martinez, D; Martínez, Y; Casallanovo, F; Abuin, E; Schreier, S; Lissi, E

2003-01-01

The effect of sodium dodecyl sulfate (SDS) upon the conformation and hemolytic activity of St I and St II strongly depends on its concentration. At relatively low surfactant concentrations (ca. 0.5-5mM range) the surfactant leads to the formation of aggregates, as suggested by the turbidity observed even at relatively low (micromolar range) protein concentrations. In this surfactant range, the proteins show an increase in intrinsic fluorescence intensity and reduced quenching by acrylamide, with an almost total loss of its hemolytic activity. At higher surfactant concentrations the protein adducts disaggregates. This produces a decrease in fluorescence intensity, increase in quenching efficiency by acrylamide, loss of the native tertiary conformation (as reported by the near UV-CD spectra), and increase in alpha-helix content (as evidenced by the far UV-CD spectra). However, and in spite of these substantial changes, the toxins partially recover their hemolytic activity. The reasons for this recovering of the activity at high surfactant concentrations is discussed.

Forecasts and predictions of eruptive activity at Mount St. Helens, USA: 1975-1984

USGS Publications Warehouse

Swanson, D.A.; Casadevall, T.J.; Dzurisin, D.; Holcomb, R.T.; Newhall, C.G.; Malone, S.D.; Weaver, C.S.

1985-01-01

Public statements about volcanic activity at Mount St. Helens include factual statements, forecasts, and predictions. A factual statement describes current conditions but does not anticipate future events. A forecast is a comparatively imprecise statement of the time, place, and nature of expected activity. A prediction is a comparatively precise statement of the time, place, and ideally, the nature and size of impending activity. A prediction usually covers a shorter time period than a forecast and is generally based dominantly on interpretations and measurements of ongoing processes and secondarily on a projection of past history. The three types of statements grade from one to another, and distinctions are sometimes arbitrary. Forecasts and predictions at Mount St. Helens became increasingly precise from 1975 to 1982. Stratigraphic studies led to a long-range forecast in 1975 of renewed eruptive activity at Mount St. Helens, possibly before the end of the century. On the basis of seismic, geodetic and geologic data, general forecasts for a landslide and eruption were issued in April 1980, before the catastrophic blast and landslide on 18 May 1980. All extrusions except two from June 1980 to the end of 1984 were predicted on the basis of integrated geophysical, geochemical, and geologic monitoring. The two extrusions that were not predicted were preceded by explosions that removed a substantial part of the dome, reducing confining pressure and essentially short-circuiting the normal precursors. ?? 1985.

Master Mentors: Linda Golian-Lui University of Hawaii-Hilo--George Oberle George Mason University, VA

ERIC Educational Resources Information Center

Library Journal, 2005

2005-01-01

Many movers and shakers inspire admiration and even awe, but those who inspire love are the mentors who have changed lives. That is why many grateful librarians nominated Linda Golian-Lui and George Oberle. Both of them were accidental librarians, work-study students whose supervisors encouraged them to become paraprofessionals, and then…

76 FR 10564 - Takes of Marine Mammals Incidental to Specified Activities; St. George Reef Light Station...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-25

.... Acoustic and visual stimuli generated by: (1) Helicopter landings/takeoffs; (2) noise generated during... minimize acoustic and visual disturbances) as described in NMFS' December 22, 2010 (75 FR 80471) notice of... Activity on Marine Mammals Acoustic and visual stimuli generated by: (1) Helicopter landings/ takeoffs; (2...

78 FR 71576 - Takes of Marine Mammals Incidental to Specified Activities; St. George Reef Light Station...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-29

... species composition, age and sex class of pinnipeds using the project site during human activity periods...; Fate of the animal(s); and Photographs or video footage of the animal(s) (if equipment is available... hours of the discovery. The Society will provide photographs or video footage (if available) or other...

76 FR 79157 - Takes of Marine Mammals Incidental to Specified Activities; St. George Reef Light Station...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-21

... during the Sunday work window period. Although some of these flights would be conducted solely for the... or up to two times per year within the proposed work window. Scheduled light maintenance activities... people to the Station by helicopter to repair the beacon light. For each emergency repair event, the...

Depositional environment of near-surface sediments, King George Basin, Bransfield Strait, Antarctica

NASA Astrophysics Data System (ADS)

Yoon, H. I.; Park, B. K.; Chang, S. K.; Han, M. W.; Oh, J. K.

1994-03-01

Four sediment cores were collected to determine the depositional environments of the King George Basin northeast of Bransfield Strait, Antarctica. The cored section revealed three distinct lithofacies: laminated siliceous ooze derived from an increased paleoproductivity near the receding sea-ice edges, massive muds that resulted from hemipelagic sedimentation in open water, and graded sediments that originated from nearby local seamounts by turbidity currents. Clay mineral data of the cores indicate a decreasing importance of volcanic activity through time. Active volcanism and hydrothermal activity appear to be responsible for the enrichment of smectite near the Penguin and Bridgeman Islands.

The association of lung function and St. George's respiratory questionnaire with exacerbations in COPD: a systematic literature review and regression analysis.

PubMed

Martin, Amber L; Marvel, Jessica; Fahrbach, Kyle; Cadarette, Sarah M; Wilcox, Teresa K; Donohue, James F

2016-04-16

This study investigated the relationship between changes in lung function (as measured by forced expiratory volume in one second [FEV1]) and the St. George's Respiratory Questionnaire (SGRQ) and economically significant outcomes of exacerbations and health resource utilization, with an aim to provide insight into whether the effects of COPD treatment on lung function and health status relate to a reduced risk for exacerbations. A systematic literature review was conducted in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials to identify randomized controlled trials of adult COPD patients published in English since 2002 in order to relate mean change in FEV1 and SGRQ total score to exacerbations and hospitalizations. These predictor/outcome pairs were analyzed using sample-size weighted regression analyses, which estimated a regression slope relating the two treatment effects, as well as a confidence interval and a test of statistical significance. Sixty-seven trials were included in the analysis. Significant relationships were seen between: FEV1 and any exacerbation (time to first exacerbation or patients with at least one exacerbation, p = 0.001); between FEV1 and moderate-to-severe exacerbations (time to first exacerbation, patients with at least one exacerbation, or annualized rate, p = 0.045); between SGRQ score and any exacerbation (time to first exacerbation or patients with at least one exacerbation, p = 0.0002) and between SGRQ score and moderate-to-severe exacerbations (time to first exacerbation or patients with at least one exacerbation, p = 0.0279; annualized rate, p = 0.0024). Relationships between FEV1 or SGRQ score and annualized exacerbation rate for any exacerbation or hospitalized exacerbations were not significant. The regression analysis demonstrated a significant association between improvements in FEV1 and SGRQ score and lower risk for COPD exacerbations. Even in cases of non-significant relationships

Superstitions of George Bartisch.

PubMed

Blanchard, Donald L

2005-01-01

George Bartisch was a 16th century German ophthalmologist who published the first ophthalmology textbook in the vernacular for laymen and non-university-trained practitioners. His treatments and understanding of diseases rested firmly on Greek tradition, but he also was very involved in the superstitions of the day. This essay looks at the man and his mores. Bartisch believed that much of the suffering of patients had to do with sins they had committed, and that the devil was the active force in the world inflicting this punishment. Often, he believed, witches would carry out the devil's hexes, in the form of either hot or cold witchcraft. Bartisch also felt that astrology played a major role in the outcome of surgery. Because of that he practiced only during certain astrological signs, and in the proper waxing and waning phases of the moon. He also linked many common problems to sins. For example, presbyopia was presented as due to excessive use of alcohol. Glasses were to be avoided because he felt they destroyed vision in themselves. Despite these superstitions and misconceptions, Bartisch was an honorable professional and his books give insight into the making of a good ophthalmologist.

George Low: From Spaceships to Scholarship.

ERIC Educational Resources Information Center

Grady, Denise

1982-01-01

Recounts the life of George Low focusing on his first career with NASA where he began as a research scientist and finished as deputy administrator and his second career as president of Rensselaer Polytechnic Institute. Emphasizes his personal drive, competitive nature, managerial skills, and innovative ideas. (DC)

Mount St. Helens erupts again: activity from September 2004 through March 2005

USGS Publications Warehouse

Major, Jon J.; Scott, William E.; Driedger, Carolyn; Dzurisin, Dan

2005-01-01

Eruptive activity at Mount St. Helens captured the world’s attention in 1980 when the largest historical landslide on Earth and a powerful explosion reshaped the volcano, created its distinctive crater, and dramatically modified the surrounding landscape. Over the next 6 years, episodic extrusions of lava built a large dome in the crater. From 1987 to 2004, Mount St. Helens returned to a period of relative quiet, interrupted by occasional, short-lived seismic swarms that lasted minutes to days, by months-to-yearslong increases in background seismicity that probably reflected replenishment of magma deep underground, and by minor steam explosions as late as 1991. During this period a new glacier grew in the crater and wrapped around and partly buried the lava dome. Although the volcano was relatively quiet, scientists with the U.S. Geological Survey and University of Washington’s Pacific Northwest Seismograph Network continued to closely monitor it for signs of renewed activity.

George Washington and the Temple of Democracy. Teaching with Historic Places.

ERIC Educational Resources Information Center

Hunter, Kathleen A.

This document, from the lesson plan series, "Teaching with Historic Places," provides a description of George Washington's life and the building of the U.S. Capitol. George Washington became the first U.S. President after leading the colonies through the revolutionary war. The U.S. Congress and the President decided to create a federal…

Serum Levels of Interleukin 33 and Soluble ST2 Are Associated with the Extent of Disease Activity and Cutaneous Manifestations in Patients with Active Adult-onset Still's Disease.

PubMed

Han, Jae Ho; Suh, Chang-Hee; Jung, Ju-Yang; Ahn, Mi-Hyun; Kwon, Ji Eun; Yim, Hyunee; Kim, Hyoun-Ah

2017-06-01

Interleukin 33 (IL-33), a member of the IL-1 family and a ligand of the orphan receptor ST2, plays key roles in innate and adaptive immunity. We examined the associations between IL-33/ST2 levels and clinical manifestations of patients with active adult-onset Still's disease (AOSD). Blood samples were collected from 40 patients with active AOSD, 28 patients with rheumatoid arthritis (RA), and 27 healthy controls (HC). The serum levels of IL-33 and soluble ST2 were determined using ELISA. Expression levels of IL-33 and ST2 in biopsy specimens obtained from 34 AOSD patients with rash were immunohistochemically investigated. IL-33 levels of patients with AOSD were higher than those of patients with RA and HC. Soluble ST2 levels of patients with AOSD were higher than those of HC, but not of patients with RA. Serum IL-33 levels correlated with systemic score, erythrocyte sedimentation rate, ferritin levels, and aspartate transaminase levels. However, serum soluble ST2 levels correlated only with ferritin levels. The numbers of inflammatory cells expressing IL-33 and ST2 were elevated in skin lesions of patients with AOSD compared to HC, but did not differ from those of the skin lesions of eczema or psoriasis. We found significantly higher serum IL-33 and soluble ST2 levels in patients with active AOSD. Results indicate that the IL-33/ST2 signaling pathway may play a role in the pathogenesis of the acute inflammation and skin manifestations associated with AOSD.

George Sand: A Life of Conflict

ERIC Educational Resources Information Center

Pappas, Dee Ann

1970-01-01

This discussion on George Sand illustrates the dilemma of the woman who is curious and aggressive in a social milieu which is not ready to accept her in that light. The world in which she lived could not permit a realization of the ideal vision she held. (Author/CJ)

George Washington: A Grounded Leader

DTIC Science & Technology

2011-04-08

not well educated in a formal sense, George Washington was highly intellectual. His commitment to self -improvement, coupled with native abilities, and...and additional qualifiers separated by commas, e.g. Smith, Richard, Jr. 7. PERFORMING ORGANIZATION NAME{S) AND ADDRESS{ES). Self -explanatory. 8...PERMITTED PROVIDED PROPER ACKNOWLEDGEMENT IS MADE. ii Acknowledgements In the beginning was Dr. Donald F. Bittner. Dr. Bittner was my esteemed faculty

Ritchey, George Willis (1864-1945)

NASA Astrophysics Data System (ADS)

Murdin, P.

2000-11-01

At first a furniture-maker and woodworker, became an instrument-maker and especially an optician when he obtained part-time work at the observatory of the University of Cincinnati. Met GEORGE ELLERY HALE in Chicago and volunteered to assist him, preparing photographic plates, learning to use the camera to photograph stars and nebulae. Became a full time optician and supervisor of the instrument s...

The Oral History of Evaluation: The Professional Development of George Grob

ERIC Educational Resources Information Center

Miller, Robin L.; Caracelli, Valerie J.

2014-01-01

In this article the authors present the full interview conducted with George Grob in 2011 at the American Evaluation Association (AEA) Conference in Anaheim, CA. George Grob is former Director of the Office of Evaluation and Inspections in the Office of Inspector General. Prior to serving in that Office, he was Director of Planning and Policy…

Plaster People...A La George Segal.

ERIC Educational Resources Information Center

Boulay, Michele

2003-01-01

Describes an art project used with eleventh- and twelfth-grade students in which they created plaster self-portraits inspired by the work of George Segal. Includes directions for the casting and lists the art materials needed for the lesson. Explains that the project requires half a semester to complete. (CMK)

Teaching about George Washington. ERIC Digest.

ERIC Educational Resources Information Center

Vontz, Thomas S.; Nixon, William A.

No generation in U.S. history has matched that of the founding era for its array of talented and influential political thinkers and actors. These individuals (such as George Washington, John Adams, Benjamin Franklin, Alexander Hamilton, Thomas Jefferson, and James Madison) possessed traits of character and intellect that significantly shaped the…

ACTH Action on StAR Biology

PubMed Central

Clark, Barbara J.

2016-01-01

Adrenocorticotropin hormone (ACTH) produced by the anterior pituitary stimulates glucocorticoid synthesis by the adrenal cortex. The first step in glucocorticoid synthesis is the delivery of cholesterol to the mitochondrial matrix where the first enzymatic reaction in the steroid hormone biosynthetic pathway occurs. A key response of adrenal cells to ACTH is activation of the cAMP-protein kinase A (PKA) signaling pathway. PKA activation results in an acute increase in expression and function of the Steroidogenic Acute Regulatory protein (StAR). StAR plays an essential role in steroidogenesis- it controls the hormone-dependent movement of cholesterol across the mitochondrial membranes. Currently StAR's mechanism of action remains a major unanswered question in the field. However, some insight may be gained from understanding the mechanism(s) controlling the PKA-dependent phosphorylation of StAR at S194/195 (mouse/human StAR), a modification that is required for function. This mini-review provides a background on StAR's biology with a focus on StAR phosphorylation. The model for StAR translation and phosphorylation at the outer mitochondrial membrane, the location for StAR function, is presented to highlight a unifying theme emerging from diverse studies. PMID:27999527

ACTH Action on StAR Biology.

PubMed

Clark, Barbara J

2016-01-01

Adrenocorticotropin hormone (ACTH) produced by the anterior pituitary stimulates glucocorticoid synthesis by the adrenal cortex. The first step in glucocorticoid synthesis is the delivery of cholesterol to the mitochondrial matrix where the first enzymatic reaction in the steroid hormone biosynthetic pathway occurs. A key response of adrenal cells to ACTH is activation of the cAMP-protein kinase A (PKA) signaling pathway. PKA activation results in an acute increase in expression and function of the Steroidogenic Acute Regulatory protein (StAR). StAR plays an essential role in steroidogenesis- it controls the hormone-dependent movement of cholesterol across the mitochondrial membranes. Currently StAR's mechanism of action remains a major unanswered question in the field. However, some insight may be gained from understanding the mechanism(s) controlling the PKA-dependent phosphorylation of StAR at S194/195 (mouse/human StAR), a modification that is required for function. This mini-review provides a background on StAR's biology with a focus on StAR phosphorylation. The model for StAR translation and phosphorylation at the outer mitochondrial membrane, the location for StAR function, is presented to highlight a unifying theme emerging from diverse studies.

Connect the Book. George Washington's Teeth

ERIC Educational Resources Information Center

Brodie, Carolyn S.

2005-01-01

February celebrates both National Children's Dental Health Month and President's Day (February 21), so this month's "Connect the Book" column features a book with connections to both events. George Washington, the first President of the United States (1789-1797) and known as the "Father of Our Country," had a serious dental health problem that…

On the Teachings of George Grant

ERIC Educational Resources Information Center

Pinar, William F.

2014-01-01

One of Canada's greatest public intellectuals, George Grant (1918-1988) studied history as an undergraduate, focusing on concepts and themes rather than minutiae. That same intellectual disposition surfaced later at Oxford, where he had gone on a Rhodes scholarship to study law. Returning to Oxford after the war, he left law to study theology,…

Breast irradiation causes pallor in the nipple-areolar complex in women with Celtic skin type (result from the St. George and Wollongong randomised breast boost trial).

PubMed

Lee, Yoo Young Dominique; Hau, Eric; Browne, Lois H; Chin, Yaw; Lee, Jessica; Szwajcer, Alison; Cail, Stacy; Nolan, David N; Graham, Peter H

2014-04-01

The nipple-areolar complex (NAC) has special histological properties with higher melanocyte concentration than breast skin. To date, there are no data describing the late effects on the NAC following breast-conserving therapy (BCT). This study evaluated colour changes in the NAC in patients treated with breast-conserving surgery and adjuvant radiotherapy after 5 years. Digital photographs obtained at 5 years following breast irradiation from the St. George and Wollongong (SGW) trial (NCT00138814) were evaluated by five experts using an iPad® (Apple Inc., Cupertino, CA, USA) application specifically created for this study. The SGW trial randomised 688 patients with Tis-2, N0-1, M0 carcinoma to the control arm of 50 Gy in 25 fractions and boost arm of 45 Gy in 25 fractions and 16 Gy in 8 fractions electron boost. A total of 141/372 (38%) patients had altered NAC (86% lighter, 10% darker). Patients with Celtic skin type had increased likelihood of having an altered NAC (odds ratio (OR), 1.75 (CI 1.1-2.7, P = 0.011)). On subgroup analysis, those with Celtic skin type receiving biologically equivalent dose (BED) Gy3 ≥ 80 Gy had OR of 3.03 (95% CI 1.2-7.5, P = 0.016) for having altered colour. There was a dose response with more profound changes seen in the NAC compared with irradiated breast skin if BED Gy3 ≥ 80 Gy with OR of 2.42 (95% CI 1.1-5.6, P = 0.036). In this Caucasian BCT population, over 30% of patients developed lighter NAC and more commonly in women with Celtic skin type. The degree of this effect increased with higher radiation dose. © 2014 The Royal Australian and New Zealand College of Radiologists.

Isolation and characterization of a Solanum tuberosum subtilisin-like protein with caspase-3 activity (StSBTc-3).

PubMed

Fernández, María Belén; Daleo, Gustavo Raúl; Guevara, María Gabriela

2015-01-01

Plant proteases with caspase-like enzymatic activity have been widely studied during the last decade. Previously, we have reported the presence and induction of caspase-3 like activity in the apoplast of potato leaves during Solanum tuberosum- Phytophthora infestans interaction. In this work we have purified and identified a potato extracellular protease with caspase-3 like enzymatic activity from potato leaves infected with P. infestans. Results obtained from the size exclusion chromatography show that the isolated protease is a monomeric enzyme with an estimated molecular weight of 70 kDa approximately. Purified protease was analyzed by MALDI-TOF MS, showing a 100% of sequence identity with the deduced amino acid sequence of a putative subtilisin-like protease from S. tuberosum (Solgenomics protein ID: PGSC0003DMP400018521). For this reason the isolated protease was named as StSBTc-3. This report constitutes the first evidence of isolation and identification of a plant subtilisin-like protease with caspase-3 like enzymatic activity. In order to elucidate the possible function of StSBTc-3 during plant pathogen interaction, we demonstrate that like animal caspase-3, StSBTc-3 is able to produce in vitro cytoplasm shrinkage in plant cells and to induce plant cell death. This result suggest that, StSBTc-3 could exert a caspase executer function during potato- P. infestans interaction, resulting in the restriction of the pathogen spread during plant-pathogen interaction. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Preserved pharmacological activity of hepatocytes-treated extracts of valerian and St. John's wort.

PubMed

Simmen, Urs; Saladin, Caroline; Kaufmann, Priska; Poddar, Manisha; Wallimann, Christine; Schaffner, Willi

2005-07-01

The two herbal extracts valerian (Valeriana officinalis L.) and St. John's wort (Hypericum perforatum L.) were studied for their metabolic changes upon incubation with freshly prepared rat hepatocytes and subsequently analysed phytochemically as well as pharmacologically in vitro. Quantitative HPLC analysis of valerian extracts revealed considerable metabolic activities with regard to sesquiterpenes and iridoids. The amount of acetoxyvalerenic acid decreased 9-fold, while that of hydroxyvalerenic acid correspondingly increased 9-fold due to O-deacetylation. The valepotriates didrovaltrate, isovaltrate and valtrate decreased 2-, 18- and 16-fold, respectively. However, the binding affinities of the incubated extracts to the benzodiazepine and picrotoxin binding site of the GABA (A) receptor were quite similar to those of the non-incubated extracts. Neither valerenic acids nor valepotriates exhibited any significant effect on the two binding sites when tested as single compounds. Therefore, either other constituents represent the active ones or multiple compounds are necessary for the observed inhibitory and allosteric effects at the GABA (A) receptor. Extracts of St. John's wort were less potently metabolised than valerian. The amount of pseudohypericin and the main flavonoids (hyperoside, rutin, isoquercitrin, quercitrin, quercetin and I3,II8-biapigenin) slightly decreased during the 4-h incubation period. Both the antagonist effect at the corticotropin-releasing factor (CRF) type 1 receptor and the binding inhibition at the 5-HT transporter were attenuated during the metabolic treatment. The reduced antagonist effect correlates with the decreasing amount of pseudohypericin known to be a CRF (1) receptor antagonist. In conclusion, the incubation of plant extracts with freshly prepared rat hepatocytes represents a useful approach to study the pharmacological action of metabolised plant extracts. The consistent pharmacological activity of both valerian and St. John

Environmental Impact Statement. Disposal and Reuse of George Air Force Base, California. Volume 1

DTIC Science & Technology

1992-03-01

development area. Non-aviation land uses George AFB Disposal and Reuse FEIS S -1 proposed for property within the existing base boundary Include...local communities. S -2 George AFB Disposal and Reuse FEIS The baseline assumed In this document Is the conditions projected at base closure. Impacts...of George AFB are summarized In 5. 10. and 20 year intervals in Tables S -1 through S -6 and briefly described below. Influencing factors are non

Evolution of America's pioneer bacteriologist: George M. Sternberg's formative years.

PubMed

Flaumenhaft, E; Flaumenhaft, C

1993-07-01

George M. Sternberg, 1838-1915, M. D., USA, activated modern American bacteriology. He produced the first general bacteriology book in the English language in 1880. His first publications on chemical disinfection (1879) preceded Koch's Sternberg discovered the pneumococcus (1880) before Pasteur did and speculated about phagocytosis (1881) before Metchnikoff. As an experimentalist and author, Sternberg stood "at the head of the American school of working bacteriologists" by the early 1880s. Our essay on Sternberg's evolution as a scientist explains what motivated him and why his early achievements as a bacteriologist, praised by contemporaries, have been underestimated more recently.

78 FR 77171 - Proposed Disposal of George H.W. Bush and Clinton Administration Electronic Backup Tapes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-20

... NATIONAL ARCHIVES AND RECORDS ADMINISTRATION [NARA-2014-011] Proposed Disposal of George H.W. Bush... George H.W. Bush and Clinton Administration Disaster Recovery Backup Tapes; final agency action. SUMMARY... collection of disaster recovery backup tapes from the George H.W. Bush and Clinton administrations under the...

Former President George H. W. Bush and Mrs. Bush visit with Mission Control Center personnel.

NASA Image and Video Library

2003-02-03

JSC2003-E-05202 (3 February 2003) --- In the Station Flight Control Room of JSC's Mission Control Center, former President George H.W. Bush learns about current activity aboard the Earth-orbiting International Space Station (ISS) from Flight Director Sally Davis. The former Chief Executive and First Lady visited the Houston facility on Feb. 3, 2003.

Ocular Toxicity Profile of ST-162 and ST-168 as Novel Bifunctional MEK/PI3K Inhibitors.

PubMed

Smith, Andrew; Pawar, Mercy; Van Dort, Marcian E; Galbán, Stefanie; Welton, Amanda R; Thurber, Greg M; Ross, Brian D; Besirli, Cagri G

2018-04-30

ST-162 and ST-168 are small-molecule bifunctional inhibitors of MEK and PI3K signaling pathways that are being developed as novel antitumor agents. Previous small-molecule and biologic MEK inhibitors demonstrated ocular toxicity events that were dose limiting in clinical studies. We evaluated in vitro and in vivo ocular toxicity profiles of ST-162 and ST-168. Photoreceptor cell line 661W and adult retinal pigment epithelium cell line ARPE-19 were treated with increasing concentrations of bifunctional inhibitors. Western blots, cell viability, and caspase activity assays were performed to evaluate MEK and PI3K inhibition and dose-dependent in vitro toxicity, and compared with monotherapy. In vivo toxicity profile was assessed by intravitreal injection of ST-162 and ST-168 in Dutch-Belted rabbits, followed by ocular examination and histological analysis of enucleated eyes. Retinal cell lines treated with ST-162 or ST-168 exhibited dose-dependent inhibition of MEK and PI3K signaling. Compared with inhibition by monotherapies and their combinations, bifunctional inhibitors demonstrated reduced cell death and caspase activity. In vivo, both bifunctional inhibitors exhibited a more favorable toxicity profile when compared with MEK inhibitor PD0325901. Novel MEK and PI3K bifunctional inhibitors ST-162 and ST-168 demonstrate favorable in vitro and in vivo ocular toxicity profiles, supporting their further development as potential therapeutic agents targeting multiple aggressive tumors.

75 FR 33631 - Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-14

... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0040] Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission for Review; Information Collection Request for the Department of Homeland Security (DHS) Science and Technology TechSolutions Program AGENCY...

75 FR 53706 - Science and Technology (S&T) Directorate: Agency Information Collection Activities: Submission...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-01

... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0072] Science and Technology (S&T) Directorate: Agency Information Collection Activities: Submission for Review; Information Collection Request for the Department of Homeland Security (DHS) Science and Technology TechSolutions Program AGENCY...

George H. Morrison--A Scottish Edwardian Preacher?

ERIC Educational Resources Information Center

Brack, Harold A.

Unique in its communication effectiveness, the preaching style of George H. Morrison cannot be defined according to a particular communication classification system. Morrison's preaching reflected his deep concern for the individual person through simplicity of language, certainty of word choice, confident assertion of Scripture, and careful…

Final Comments from Professors George and Beane.

ERIC Educational Resources Information Center

Beane, James; George, Paul S.

1996-01-01

Concludes this journal focus section on curriculum integration with transcripts of questions asked by conference attendees and answers by Professors Beane and George. Areas addressed included experience levels with children and teachers, studies that point to the failure of curriculum integration, and how teachers can continue curriculum…

ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease

PubMed Central

Zhang, Jilu; Ramadan, Abdulraouf M.; Griesenauer, Brad; Li, Wei; Turner, Matthew J.; Liu, Chen; Kapur, Reuben; Hanenberg, Helmut; Blazar, Bruce R.; Tawara, Isao; Paczesny, Sophie

2015-01-01

Graft-versus-host disease (GVHD) remains a devastating complication after allogeneic hematopoietic cell transplantation (HCT). We previously identified high plasma soluble suppression of tumorigenicity 2 (sST2) as a biomarker of the development of GVHD and death. sST2 sequesters interleukin (IL)-33, limiting its availability to T cells expressing membrane-bound ST2 (mST2) [Th2 cells and ST2+FoxP3+regulatory T cells]. Here, we report that blockade of sST2 in the peri-transplant period with a neutralizing monoclonal antibody (anti-ST2 mAb) reduced GVHD severity and mortality. We identified intestinal stromal cells and T cells as major sources of sST2 during GVHD. ST2 blockade decreased systemic interferon-γ, IL-17, and IL-23 but increased IL-10 and IL-33 plasma levels. ST2 blockade also reduced sST2 production by IL-17–producing T cells while maintaining protective mST2-expressing T cells, increasing the frequency of intestinal myeloid-derived suppressor cells, and decreasing frequency of intestinal CD103 dendritic cells. Finally, ST2 blockade preserved graft-versus-leukemia activity in a model of GFP+MLL-AF9 acute myeloid leukemia. Our findings suggest that ST2 is a therapeutic target for severe GVHD, and that the ST2/IL-33 pathway could be investigated in other T-cell mediated immune disorders with loss of tolerance. PMID:26446957

75 FR 36441 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-25

... 7th St, Hiawatha, 10000450 Chase County Shaft, William C. & Jane, House, 1682 FP Rd, Cedar Point..., Bat St. Louis, 10000441 Hinds County George Street Grocery, 416 George St, Jackson, 10000438 Leflore... Grocer Company Warehouse, 323 N. Patton Ave, Springfield, 10000462 Jackson County Montgomery Ward and...

75 FR 35831 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-23

... 7th St, Hiawatha, 10000450 Chase County Shaft, William C. & Jane, House, 1682 FP Rd, Cedar Point... * * *, Bat St. Louis, 10000441 Hinds County George Street Grocery, 416 George St, Jackson, 10000438 [[Page... Springfield Grocer Company Warehouse, 323 N. Patton Ave, Springfield, 10000462 Jackson County Montgomery Ward...

StInvInh2 as an inhibitor of StvacINV1 regulates the cold-induced sweetening of potato tubers by specifically capping vacuolar invertase activity.

PubMed

Liu, Xun; Lin, Yuan; Liu, Jun; Song, Botao; Ou, Yongbin; Zhang, Huiling; Li, Meng; Xie, Conghua

2013-06-01

Reducing sugar (RS) accumulation in cold-stored potato tubers, known as cold-induced sweetening (CIS), is a crucial factor causing unacceptable colour changes and acrylamide formation of fried products. The activity of vacuolar invertase (StvacINV1) is proved important for the CIS process, and invertase inhibitors are speculated to play roles in the post-translational regulation of StvacINV1 activity. In our previous research, two putative inhibitors (StInvInh2A and StInvInh2B) of StvacINV1 were implied to be involved in potato CIS. Here, we further reported that StInvInh2A and StInvInh2B had similar function that specifically inhibited StvacINV1 activity in potatoes. The genetic transformation of these inhibitor genes in potatoes by overexpression in CIS-sensitive and RNAi-silenced in CIS-resistant genotypes showed that StvacINV1 activity was strongly regulated by alteration of the transcripts of the inhibitors without impacting on the expression of StvacINV1. A negative power relationship was found between the transcripts of the inhibitors and StvacINV1 activity, suggesting 1) a transcriptional determination of the inhibitory capacity of StInvInh2A and StInvInh2B and 2) a significant inhibitory role of these inhibitors in post-translational modulation of StvacINV1. The results also demonstrated that depression of StvacINV1 activity through overexpression of StInvInh2A and StInvInh2B weakened accumulation of RS and acrylamide in cold-stored tubers and consequently improved the chip quality. The present research strongly suggest that both StInvInh2A and StInvInh2B function as inhibitors of StvacINV1 and play similar roles in regulating potato CIS by capping StvacINV1 activity. These inhibitors could be novel genetic resources applicable for improving quality of potato processing products. © 2013 Society for Experimental Biology, Association of Applied Biologists and John Wiley & Sons Ltd.

In Praise of George Peabody, 1795-1869.

ERIC Educational Resources Information Center

Parker, Franklin

1994-01-01

One of several papers on self-made millionaire and educational philanthropist George Peabody defends Peabody's philanthropy against those who criticized him as miserly, highlighting his establishment of colleges, libraries, museums, hospitals, and other charities. The paper details his life, work, politics, and death, describing the causes that he…

George A. Towns Elementary School. Atlanta, Georgia

ERIC Educational Resources Information Center

Burt, Ralph H.

1976-01-01

A project testing solar heating and cooling in an existing building, the George A. Towns Elementary School, is intended to provide information on system design and performance, allow the identification and correction of problems encountered in installing large units, and gauge community/user reaction to solar equipment. (Author/MLF)

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

PubMed Central

Moore, Linda B.; Goodwin, Bryan; Jones, Stacey A.; Wisely, G. Bruce; Serabjit-Singh, Cosette J.; Willson, Timothy M.; Collins, Jon L.; Kliewer, Steven A.

2000-01-01

St. John's wort (Hypericum perforatum) is an herbal remedy used widely for the treatment of depression. Recent clinical studies demonstrate that hypericum extracts increase the metabolism of various drugs, including combined oral contraceptives, cyclosporin, and indinavir. In this report, we show that hyperforin, a constituent of St. John's wort with antidepressant activity, is a potent ligand (Ki = 27 nM) for the pregnane X receptor, an orphan nuclear receptor that regulates expression of the cytochrome P450 (CYP) 3A4 monooxygenase. Treatment of primary human hepatocytes with hypericum extracts or hyperforin results in a marked induction of CYP3A4 expression. Because CYP3A4 is involved in the oxidative metabolism of >50% of all drugs, our findings provide a molecular mechanism for the interaction of St. John's wort with drugs and suggest that hypericum extracts are likely to interact with many more drugs than previously had been realized. PMID:10852961

Enhancement of knowledge construction activities utilizing 21st century learning design rubric

NASA Astrophysics Data System (ADS)

Pedoche, Margarette Anne U.; Taladua, Janica Mae M.; Panal, Geicky Pearl C.; Magsayo, Joy R.; Guarin, Rica Mae B.; Myrna, H. Lahoylahoy

2018-01-01

The main objective of the study was to enhance knowledge construction activities on its design particularly the objectives, support materials, student activities and assessment tools. Activities from the 2nd Quarter of Science Learners Material were the basis in the adaptation of activities. The adapted activities were evaluated by the In-service Science teachers and undergone modification by the researchers based on the teacher's comments and suggestions. It was then evaluated, revised, and validated, tried-out using the 21st CLD Rubric. Subjects of the study were 110 students from Grade 7-B, Grade 7-D, Grade 7-F in Geronima Cabrera National High School, Kolambugan, Lanao del Norte during the academic year 2016-2017, the study to determine their learning capabilities investigated by the use of Knowledge Construction Activities in the 21st Century Classroom, to investigate how the lessons were understood and appreciated by students, to stimulate interpretation, analysis, synthesizing, or evaluating ideas and develop critical thinking. Both quantitative and qualitative data were obtained from the students' scores in three activities. Results showed that there was a significant difference between the pretest and posttest scores of students. Mean scores between the pretest and posttest showed a mean difference of 3.35, thus the null hypothesis was rejected. It could be concluded with sufficient evidence to show that the students had basically low prior knowledge about the topic ecosystem. A significant difference was seen in the pretest and posttest, scores of the activities and Ecosystem model results after the implementation phase that a knowledge construction type of activity was better than the traditional one for it promoted meaningful learning and active engagement of students. Based on the results, it was clear that the use of knowledge construction activities had an effect on student's achievement in comparison to traditional teaching method. Thus, it was

Mobility match study in Prince George's County, Maryland

DOT National Transportation Integrated Search

1994-11-01

The primary focus of this study was to develop non-traditional transit : alternatives to better serve the residents of Prince George's County. The study : identified the transportation needs of the area, evaluated the applicabilty of : traditional an...

The 21st century skills with model eliciting activities on linear program

NASA Astrophysics Data System (ADS)

Handajani, Septriana; Pratiwi, Hasih; Mardiyana

2018-04-01

Human resources in the 21st century are required to master various forms of skills, including critical thinking skills and problem solving. The teaching of the 21st century is a teaching that integrates literacy skills, knowledge, skills, attitudes, and mastery of ICT. This study aims to determine whether there are differences in the effect of applying Model Elliciting Activities (MEAs) that integrates 21st century skills, namely 4C and conventional learning to learning outcomes. This research was conducted at Vocational High School in the odd semester of 2017 and uses the experimental method. The experimental class is treated MEAs that integrates 4C skills and the control class is given conventional learning. Methods of data collection in this study using the method of documentation and test methods. The data analysis uses Z-test. Data obtained from experiment class and control class. The result of this study showed there are differences in the effect of applying MEAs that integrates 4C skills and conventional learning to learning outcomes. Classes with MEAs that integrates 4C skills give better learning outcomes than the ones in conventional learning classes. This happens because MEAs that integrates 4C skills can improved creativity skills, communication skills, collaboration skills, and problem-solving skills.

George Washington: A Hero for American Students?

ERIC Educational Resources Information Center

Jordan, Ervin L., Jr.; Bennett, Clifford T.

1997-01-01

Discusses the career of George Washington with specific emphasis on his racial views and his role as a slaveholder. Describes Washington as a man bound by racial and political mores of his time. Although troubled by certain aspects of slavery, Washington directly benefited from the operation of this system. (MJP)

DiGeorge Syndrome: a not so rare disease.

PubMed

Fomin, Angela B F; Pastorino, Antonio Carlos; Kim, Chong Ae; Pereira, C A; Carneiro-Sampaio, Magda; Abe-Jacob, Cristina Miuki

2010-01-01

The DiGeorge Syndrome was first described in 1968 as a primary immunodeficiency resulting from the abnormal development of the third and fourth pharyngeal pouches during embryonic life. It is characterized by hypocalcemia due to hypoparathyroidism, heart defects, and thymic hypoplasia or aplasia. Its incidence is 1:3000 live births and, despite its high frequency, little is known about its natural history and progression. ←This is probably due to diagnostic difficulties and the great variety of names used to describe it, such as velocardiofacial, Shprintzen, DiGeorge, and CATCH 22 Syndromes, as well as conotruncal facial anomaly. All represent the same genetic condition, chromosome 22q11.2 deletion, which might have several clinical expressions. To describe clinical and laboratorial data and phenotypic characteristics of patients with DiGeorge Syndrome. Patients underwent standard clinical and epidemiological protocol and tests to detect heart diseases, facial abnormalities, dimorphisms, neurological or behavioral disorders, recurrent infections and other comorbidities. Of 14 patients (8m - 18y11m), only one did not have 22q11.2 deletion detected. The main findings were: conotruncal malformation (n = 12), facial abnormalities (n = 11), hypocalcemia (n = 5) and low lymphocyte count (n=2). The authors pointed out the necessity of DGS suspicion in all patient presenting with heart defects, facial abnormalities (associated or not with hypocalcemia), and immunological disorders because although frequency of DGS is high, few patients with a confirmed diagnosis are followed up.

Digital imaging of autoradiographs from paintings by Georges de La Tour (1593-1652)

NASA Astrophysics Data System (ADS)

Fischer, C.-O.; Gallagher, M.; Laurenze, C.; Schmidt, Ch; Slusallek, K.

1999-11-01

The artistic work of the painter Georges de La Tour has been studied very intensively in the last few years, mainly by French and US-American art historians and natural scientists. To support the in-depth analysis of two paintings from the Kimbell Art Museum in Fort Worth, Texas, USA, two similar paintings from the Gemäldegalerie Berlin have been investigated. The method of neutron activation autoradiography has been applied using imaging plates with digital image processing.

A New Look at the Magnetostratigraphy and Paleomagnetism of the Upper Triassic to Lower Jurassic Moenave Formation, St. George Area, Southwestern Utah.

NASA Astrophysics Data System (ADS)

Donohoo-Hurley, L. L.; Geissman, J. W.; Lucas, S. G.; Roy, M.

2006-12-01

Paleomagnetic data from rocks exposed on and off the Colorado Plateau provide poles that young westward during the Late Triassic (to about 52^{O} E longitude) and young eastward during the Early Jurassic. This pattern has been used to posit the existence of a J-1 cusp in the North American APW path at the Triassic- Jurassic boundary (TJB), at about 199.6 Ma. Considerable debate has focused on the morphology and placement of the J-1 cusp due to poorly exposed and/or incompletely sampled sections, debates about the magnitude of Colorado Plateau rotation, and disagreements regarding stratigraphic relationships. Red beds of the Whitmore Point (~25 m of mostly lacustrine deposits) and Dinosaur Canyon (~55 m of hematitic fluvial sandstones and siltstones) members of the Moenave Formation (MF) are inferred to have been deposited across the TJB based on palynostratigraphy and vertebrate biostratigraphy. Two previously unsampled sections (Leeds and Warner Valley) of the MF are well exposed near St. George, Utah, and located in the transition zone that defines the western boundary of the Colorado Plateau. Preliminary data from samples collected from the Whitmore Point and Dinosaur Canyon members yield exclusively normal polarity magnetizations, which is consistent with previous studies and the normal polarity TJB magnetozone. Thermal demagnetization response suggests that the remanence is carried mainly in hematite. The degree of hematite pigmentation varies in both sections, and several Leeds sites show a weak overprint component that unblocks by 400^{O}-450^{O} C, with a higher unblocking temperature components, consistent with an Early Triassic Late Jurassic age that fully unblock around 670^{O}-680^{O} C. Individual beds (treated as specific sites) in part of the Dinosaur Canyon Member yield site mean directions with declinations between about 020 and 030, and may define the easternmost position (i.e. 60-50^{O} E latitude) of the NAMAPW path and thus the approximate the

New hypothesis helps explain elasmobranch "outburst" on Georges Bank in the 1980s.

PubMed

Frisk, M G; Miller, T J; Martell, S J D; Sosebee, K

2008-01-01

Regime shifts are a feature of many ecosystems. During the last 40 years, intensive commercial exploitation and environmental changes have driven substantial shifts in ecosystem structure and function in the northwest Atlantic. In the Georges Bank-southern New England region, commercially important species have declined, and the ecosystem shifted to one dominated by economically undesirable species such as skates and dogfish. Aggregated abundance indices indicate a large increase of small and medium-sized elasmobranchs in the early 1980s following the decline of many commercial species. It has been hypothesized that ecological interactions such as competition and predation within the Georges Bank region were responsible for and are maintaining the "elasmobranch outburst" at the heart of the observed ecosystem shift. We offer an alternative hypothesis invoking population connectivity among winter skate populations such that the observed abundance increase is a result of migratory dynamics, perhaps with the Scotian Shelf (i.e., it is an open population). Here we critically evaluate the survey data for winter skate, the species principally responsible for the increase in total skate abundance during the 1980s on Georges Bank, to assess support for both hypotheses. We show that time series from different surveys within the Georges Bank region exhibit low coherence, indicating that a widespread population increase was not consistently shown by all surveys. Further, we argue that observed length-frequency data for Georges Bank indicate biologically unrealistic population fluctuations if the population is closed. Neither finding supports the elasmobranch outburst hypothesis. In contrast, survey time series for Georges Bank and the Scotian Shelf are negatively correlated, in support of the population connectivity hypothesis. Further, we argue that understanding the mechanisms of ecosystem state changes and population connectivity are needed to make inferences about both

The Education of Royalty in the Eighteenth Century: George IV and William IV

ERIC Educational Resources Information Center

Clarke, M. L.

1978-01-01

George IV, the Prince of Wales, and William IV, his younger brother, both the sons of George III, were given all the educational advantage one could be granted in the eighteenth century. The precise curriculum and practices of their teachers are discussed with an evaluation of both students as a moral for future consideration. (RK)

A Report to the Director of Libraries, on the Interlibrary Loan Service Offered at George Mason University.

ERIC Educational Resources Information Center

Connors, Maureen

A survey of the ten university libraries considered to be most comparable to George Mason University (GMU) in interlibrary loan (ILL) activity was undertaken for comparison purposes. To develop a series of recommendations for GMU with respect to ILL, the following areas were considered and are addressed in this report: (1) Divisional…

George Lakoff's New Happiness: Politics after Rationality

ERIC Educational Resources Information Center

Parrott, John B.

2009-01-01

Berkeley professor of linguistics and cognitive science George Lakoff is among the handful of current faculty members in the United States to have successfully recast himself as a significant figure in national politics. Though his views place rather far on the progressive left, he has, unlike some other scholar-activists, focused most of his…

The Context for Planning: A Report to the Jackson-George Regional Library System.

ERIC Educational Resources Information Center

McCook, Kathleen de la Pena; And Others

This report describes a study of the Jackson-George Regional Library (JGRL) System, which serves a 2-county area in Mississippi with a population of 131,918. The purpose of the study, which built on the planning and administration goals identified in "Planning for Progress: The Long Range Plan of the Jackson George Regional Library," was to…

Alexander George Karczmar (1917-2017).

PubMed

Soreq, Hermona; Silman, Israel

2017-12-01

The neurochemistry community at large and the Advisory Board of The International Symposia on Cholinergic Mechanisms mourn the loss of Alexander George Karczmar, the elected Honorary President of these international symposia, who passed away peacefully in his Chicago home at the age of 100 on August 17, 2017. For many of us Alex was the essence of cholinergic signaling, and personified its versatile power to send messages between the brain and the peripheral tissues and organs, and to connect between body and soul. © 2017 International Society for Neurochemistry.

Industrializing the near-earth asteroids: Speculations on human activities in space in the latter half of the 21st century

NASA Technical Reports Server (NTRS)

Sercel, Joel C.

1990-01-01

The use of solar system resources for human industry can be viewed as a natural extension of the continual growth of our species' habitat. Motivations for human activities in space can be discussed in terms of five distinct areas: (1) information processing and collection; (2) materials processing; (3) energy production to meet terrestrial power needs; (4) the use of extraterrestrial materials; and (5) disaster avoidance. When considering 21st-Century activities in space, each of these basic motivations must be treated in light of issues likely to be relevant to the 21st-Century earth. Many of the problems facing 21st-Century earth may stem from the need to maintain the world population of 8 to 10 billion people as is projected from expected growth rates. These problems are likely to include managing the impact of industrial processes on the terrestrial biosphere while providing adequate energy production and material goods for the growing population. The most important human activities in space in the latter half of the 21st Century may be associated with harnessing the resources of the near-earth asteroids for industrial processes. These above topics are discussed with an emphasis on space industrialization.

In Memory - George M. Byram: 1909-1996

Treesearch

Ralph M. Nelson

1996-01-01

Forest fire research lost one of its true pioneers on April 12, 1996, when George M. Byram passed away in Dunedin, Florida, at the age of 87. He made lasting contributions in nearly every subject matter area of forest fire research. He was also a gifted painter and a fine gentleman in the eyes of those who knew him.

DiGeorge Syndrome: a not so rare disease

PubMed Central

Fomin, Angela BF; Pastorino, Antonio Carlos; Kim, Chong Ae; Pereira, Alexandre C; Carneiro‐Sampaio, Magda; Abe Jacob, Cristina Miuki

2010-01-01

INTRODUCTION: The DiGeorge Syndrome was first described in 1968 as a primary immunodeficiency resulting from the abnormal development of the third and fourth pharyngeal pouches during embryonic life. It is characterized by hypocalcemia due to hypoparathyroidism, heart defects, and thymic hypoplasia or aplasia. Its incidence is 1:3000 live births and, despite its high frequency, little is known about its natural history and progression. ←This is probably due to diagnostic difficulties and the great variety of names used to describe it, such as velocardiofacial, Shprintzen, DiGeorge, and CATCH 22 Syndromes, as well as conotruncal facial anomaly. All represent the same genetic condition, chromosome 22q11.2 deletion, which might have several clinical expressions. OBJECTIVES: To describe clinical and laboratorial data and phenotypic characteristics of patients with DiGeorge Syndrome. METHODS: Patients underwent standard clinical and epidemiological protocol and tests to detect heart diseases, facial abnormalities, dimorphisms, neurological or behavioral disorders, recurrent infections and other comorbidities. RESULTS: Of 14 patients (8m – 18y11m), only one did not have 22q11.2 deletion detected. The main findings were: conotruncal malformation (n  =  12), facial abnormalities (n  =  11), hypocalcemia (n  =  5) and low lymphocyte count (n = 2). CONCLUSION: The authors pointed out the necessity of DGS suspicion in all patient presenting with heart defects, facial abnormalities (associated or not with hypocalcemia), and immunological disorders because although frequency of DGS is high, few patients with a confirmed diagnosis are followed up. PMID:21049214

'King George Island' Brushed

NASA Technical Reports Server (NTRS)

2006-01-01

[figure removed for brevity, see original site] Annotated Version

This mosaic was made from frames acquired by the microscopic imager on NASA's Mars Exploration Rover Spirit during Spirit's 1,031 Martian day, or sol, on the red planet (Nov. 27, 2006). It shows a rock target called 'King George Island' after the target was brushed by the rover's rock abrasion tool. The mosaic covers approximately 6 centimeters (2.4 inches) across and shows the granular nature of the rock exposure. The grains are typically about 1 millimeter (.04 inches) wide. Data from the rover's Moessbauer spectrometer provides evidence that they have an enhanced amount of the mineral hematite relative to surrounding soils.

Seasonal and Solar Activity Variations of f3 Layer and StF-4 F-Layer Quadruple Stratification) Near the Equatorial Region

NASA Astrophysics Data System (ADS)

Tardelli, A.; Fagundes, P. R.; Pezzopane, M.; Kavutarapu, V.

2016-12-01

The ionospheric F-layer shape and electron density peak variations depend on local time, latitude, longitude, season, solar cycle, geomagnetic activity, and electrodynamic conditions. In particular, the equatorial and low latitude F-layer may change its shape and peak height in a few minutes due to electric fields induced by propagation of medium-scale traveling ionospheric disturbances (MSTIDs) or thermospheric - ionospheric coupling. This F-layer electrodynamics feature characterizing the low latitudes is one of the most remarkable ionospheric physics research field. The study of multiple-stratification of the F-layer has the initial records in the mid of the 20th century. Since then, many studies were focused on F3 layer. The diurnal, seasonal and solar activity variations of the F3 layer characteristics have been investigated by several researchers. Recently, investigations on multiple-stratifications of F-layer received an important boost after the quadruple stratification (StF-4) was observed at Palmas (10.3°S, 48.3°W; dip latitude 5.5°S - near equatorial region), Brazil (Tardelli & Fagundes, JGR, 2015). This study present the latest findings related with the seasonal and solar activity characteristics of the F3 layer and StF-4 near the equatorial region during the period from 2002 to 2006. A significant connection between StF-4 and F3 layer has been noticed, since the StF-4 is always preceded and followed by an F3 layer appearance. However, the F3 layer and StF-4 present different seasonal and solar cycle variations. At a near equatorial station Palmas, the F3 layer shows the maximum and minimum occurrence during summer and winter seasons respectively. On the contrary, the StF-4 presents the maximum and minimum occurrence during winter and summer seasons respectively. While the F3 layer occurrence is not affected by solar cycle, the StF-4 appearance is instead more frequent during High Solar Activity (HSA).

Contrasting population trends of piscivorous seabirds in the Pribilof Islands: A 30-year perspective

USGS Publications Warehouse

Byrd, G.V.; Schmutz, J.A.; Renner, H.M.

2008-01-01

The Pribilof Islands provide nesting habitat for one of the largest concentrations of piscivorous seabirds in the North Pacific region. Pribilof breeding populations of black-legged and red-legged kittiwakes (Rissa tridactyla and Rissa brevirostris), and common and thick-billed murres (Uria aalge and Uria lomvia) are supported by a highly productive marine food web. Productivity and temperature in this area are influenced by winter sea ice that frequently reaches its maximum extent near the Pribilofs. Although St. George and St. Paul islands, the two largest of the Pribilof group, are situated only 60 km apart, St. George is within 25 km of the shelf break, but St. Paul is approximately 90 km away. In contrast, the local contribution of sea ice-edge productivity in the spring is frequently closer to St. Paul than to St. George. Central place foraging piscivorous seabirds nesting at St. Paul and St. George are likely differentially affected by the relative contributions of the shelf break and ice-edge environments based on juxtaposition. Within the past decade or so, sea ice in the Bering Sea has failed to reach the vicinity of the Pribilofs in some years, and predictions of warming in the future suggest the possibility that direct effects of the ice on the immediate Pribilof environment will be reduced. To evaluate the response of kittiwakes and murres on the two islands to conditions in their foraging environments, we examined population trends over the past 30 years based on data from the seabird monitoring program conducted by the Alaska Maritime National Wildlife Refuge and others. Spatial differences in trends have been more consistent than differences among species, with populations at St. Paul having more enduring declines than those at St. George. At St. George, black-legged kittiwakes and common murres have remained stable. Red-legged kittiwakes and thick-billed murres both declined, but began to rebound in the late 1980s, such that in 2005 population

Autobiography of Sir George Biddell Airy

NASA Astrophysics Data System (ADS)

Airy, George Biddell; Airy, Wilfred

2010-06-01

Preface; 1. Personal sketch of George Biddell Airy; 2. From his birth to his taking his B.A. degree; 3. At Trinity College, Cambridge; 4. At Cambridge Observatory; 5. At Greenwich Observatory, 1836-1846; 6. At Greenwich Observatory, 1846-1856; 7. At Greenwich Observatory, 1856-1866; 8. At Greenwich Observatory, 1866-1876; 9. At Greenwich Observatory to his resignation in 1881; 10. At the White House, Greewich, to his death; Appendix: List of printed papers; Index.

6. Historic American Buildings Survey, George J. Vaillancourt, Photographer, 1940 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Historic American Buildings Survey, George J. Vaillancourt, Photographer, 1940 LIVING ROOM FIREPLACE, FIRST STORY. - Governor James Fenner House, 41 Waterman Street, Providence, Providence County, RI

NREL Meeting to Discuss Camp George West Land Exchange

Science.gov Websites

Meeting to Discuss Camp George West Land Exchange For more information contact: Kerry Masson (303 Golden. DOE officials will discuss long-range plans for use of the property the department will acquire

Catalog of the George Alan Connor Esperanto Collection.

ERIC Educational Resources Information Center

Smith, Karin, Comp.; Haake, Susan, Comp.

This catalog inventories the collection of books, monographs, serials and periodicals, dictionaries, pamphlets, ephemera, and correspondence concerning Esperanto in the collection of George Alan Connor housed at the University of Oregon Library. Overall, the catalog contains approximately 475 serial entries and 3,000 author entries. Connor was a…

10. Historic American Buildings Survey, George J. Vaillancourt, Photographer, 1940 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Historic American Buildings Survey, George J. Vaillancourt, Photographer, 1940 VIEW OF 'GREAT SUMMER BEAM' (FIRST STORY). - Thomas Fenner House, 1538 Plainfield Street, Thornton, Providence County, RI

3. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 DETAIL, WINDOWS OF BRICK ELL - Adams-Mason House, 1072 Thomas Jefferson Street Northwest, Washington, District of Columbia, DC

1. Historic American Buildings Survey, George J. Vaillancourt, Photographer, 1938, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey, George J. Vaillancourt, Photographer, 1938, from a film by unknown, VIEW OF ORIGINAL ROOF TRUSSES. - Market House, Market Square, Providence, Providence County, RI

2. Historic American Buildings Survey, W. Eugene George Jr., Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey, W. Eugene George Jr., Photographer September, 1961 EAST ELEVATION. - Hill County Courthouse, Public Squre, Waco, Elm, Covington & Franklin Streets, Hillsboro, Hill County, TX

1. Historic American Buildings Survey, W. Eugene George Jr., Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey, W. Eugene George Jr., Photographer September, 1961 NORTHEAST ELEVATION. - Hill County Courthouse, Public Squre, Waco, Elm, Covington & Franklin Streets, Hillsboro, Hill County, TX

11. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 STAIRS FROM K STREET ENTRANCE - Capital Traction Company Powerhouse, 3142 K Street Northwest, Washington, District of Columbia, DC

8. Historic American Buildings Survey, George J. Vaillancourt, Photographer, 1940 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Historic American Buildings Survey, George J. Vaillancourt, Photographer, 1940 VIEW OF BRICK FIREPLACE (FIRST STORY, FROM SIDE). - Thomas Fenner House, 1538 Plainfield Street, Thornton, Providence County, RI

12. Historic American Buildings Survey, George J. Vaillancourt, Photographer, 1940 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Historic American Buildings Survey, George J. Vaillancourt, Photographer, 1940 FIRE-ROOM CHAMBER FIREPLACE AND OVEN (SECOND STORY). - Thomas Fenner House, 1538 Plainfield Street, Thornton, Providence County, RI

Report on George Brown College Multicultural Demonstration Project.

ERIC Educational Resources Information Center

Ward, Barbara

This five-part report describes George Brown College's Multicultural Demonstration Project (MDP), which was developed to: (1) increase awareness of issues of multicultural change among senior managers at the college; (2) assist two departments to implement aspects of the college's Race and Ethnic Relations Policy and the recommendations of the…

Biography of George Eastman: A Multiple Intelligences Profile.

ERIC Educational Resources Information Center

Hogle, Jan G.

This paper describes the life and achievements of businessman, philanthropist, and photographic innovator, George Eastman. Aspects of multiple intelligences theory with regard to Eastman's life are discussed. The paper details Eastman's many and varied successes after a poor childhood and notes that, although he left school at 13 to help support…

Prince George's Community College Marketing Plan, 1981-1982.

ERIC Educational Resources Information Center

Engleberg, Isa N., Ed.; Leach, Ernest R., Ed.

Developed by the Marketing Task Force at Prince George's Community College (PGCC) in 1981, this report presents a plan which identifies educational service needs, recommends strategies for responding to those needs, and suggests a marketing approach. The report begins by providing background on the four-stage marketing process implemented during…

Determination of element composition and extraterrestrial material occurrence in moss and lichen samples from King George Island (Antarctica) using reactor neutron activation analysis and SEM microscopy.

PubMed

Mróz, Tomasz; Szufa, Katarzyna; Frontasyeva, Marina V; Tselmovich, Vladimir; Ostrovnaya, Tatiana; Kornaś, Andrzej; Olech, Maria A; Mietelski, Jerzy W; Brudecki, Kamil

2018-01-01

Seven lichens (Usnea antarctica and U. aurantiacoatra) and nine moss samples (Sanionia uncinata) collected in King George Island were analyzed using instrumental neutron activation analysis, and concentration of major and trace elements was calculated. For some elements, the concentrations observed in moss samples were higher than corresponding values reported from other sites in the Antarctica, but in the lichens, these were in the same range of concentrations. Scanning electron microscopy (SEM) and statistical analysis showed large influence of volcanic-origin particles. Also, the interplanetary cosmic particles (ICP) were observed in investigated samples, as mosses and lichens are good collectors of ICP and micrometeorites.

Radiotherapy Breast Boost With Reduced Whole-Breast Dose Is Associated With Improved Cosmesis: The Results of a Comprehensive Assessment From the St. George and Wollongong Randomized Breast Boost Trial

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hau, Eric, E-mail: helloerico@yahoo.com; Browne, Lois H.; Khanna, Sam

Purpose: To evaluate comprehensively the effect of a radiotherapy boost on breast cosmetic outcomes after 5 years in patients treated with breast-conserving surgery. Methods: The St. George and Wollongong trial (NCT00138814) randomized 688 patients with histologically proven Tis-2, N 0-1, M0 carcinoma to the control arm of 50 Gy in 25 fractions (342 patients) and the boost arm of 45 Gy in 25 fractions to the whole breast followed by a 16 Gy in 8 fraction electron boost (346 patients). Five-year cosmetic outcomes were assessed by a panel subjectively in 385 patients and objectively using pBRA (relative breast retraction assessment).more » A subset of patients also had absolute BRA measurements. Clinician assessment and patient self-assessment of overall cosmetic and specific items as well as computer BCCT.core analysis were also performed. Results: The boost arm had improved cosmetic overall outcomes as scored by the panel and BCCT.core software with 79% (p = 0.016) and 81% (p = 0.004) excellent/good cosmesis respectively compared with 68% in no-boost arm. The boost arm also had lower pBRA and BRA values with a mean difference of 0.60 and 1.82 mm, respectively, but was not statistically significant. There was a very high proportion of overall excellent/good cosmetic outcome in 95% and 93% in the boost and no-boost arms using patient self-assessment. However, no difference in overall and specific items scored by clinician assessment and patient self-assessment was found. Conclusion: The results show the negative cosmetic effect of a 16-Gy boost is offset by a lower whole-breast dose of 45 Gy.« less

7. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 BASEMENT, FIREPLACE SUPPORT IN SOUTHWEST CORNER - Adams-Mason House, 1072 Thomas Jefferson Street Northwest, Washington, District of Columbia, DC

4. Historic American Buildings Survey, W. Eugene George, Jr., Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Historic American Buildings Survey, W. Eugene George, Jr., Photographer July, 1961 CHIMNEY DETAIL (SOUTH ELEVATION). - Eugenio Rodriguez House & Post Office, Farm Road 649, Cuevitas, Jim Hogg County, TX

5. Historic American Buildings Survey, W. Eugene George Jr., Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Historic American Buildings Survey, W. Eugene George Jr., Photographer September, 1961 WEST WINDOW DETAIL. - Hill County Courthouse, Public Squre, Waco, Elm, Covington & Franklin Streets, Hillsboro, Hill County, TX

4. Historic American Buildings Survey, W. Eugene George Jr., Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Historic American Buildings Survey, W. Eugene George Jr., Photographer September, 1961 WEST DOOR DETAIL. - Hill County Courthouse, Public Squre, Waco, Elm, Covington & Franklin Streets, Hillsboro, Hill County, TX

1. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 GENERAL VIEW WEST ALONG K STREET - Ray's Warehouse & Office, 3260-3262 K Street Northwest, Washington, District of Columbia, DC

Taxiway aircraft traffic analysis at George Bush Intercontinental Airport.

DOT National Transportation Integrated Search

2011-08-01

Serving one of the largest metropolitan areas in the United States, the George Bush Intercontinental Airport : (IAH) is among the 10 airports with the longest average taxi-out and taxi-in times. The first part of this report : assesses the congestion...

4. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 FIRST FLOOR, FRONT ROOM, FIREPLACE SOUTH WALL - Adams-Mason House, 1072 Thomas Jefferson Street Northwest, Washington, District of Columbia, DC

5. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 SECOND FLOOR, FRONT ROOM, FIREPLACE SOUTH WALL - Adams-Mason House, 1072 Thomas Jefferson Street Northwest, Washington, District of Columbia, DC

5. Historic American Buildings Survey, W. Eugene George, Jr., Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Historic American Buildings Survey, W. Eugene George, Jr., Photographer July, 1961 NORTH DOOR DETAIL (AUXILIARY BUILDING). - Eugenio Rodriguez House & Post Office, Farm Road 649, Cuevitas, Jim Hogg County, TX

5. Historic American Buildings Survey, George A. Eisenman, Photographer, 1969 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Historic American Buildings Survey, George A. Eisenman, Photographer, 1969 NORTHWEST ELEVATION SHOWING GHOST OF STAIRWAY. - Fort Mifflin, Soldiers' Barracks, Mud Island, Marine & Penrose Ferry Roads, Philadelphia, Philadelphia County, PA

3. Historic American Buildings Survey, W. Eugene George Jr., Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Historic American Buildings Survey, W. Eugene George Jr., Photographer September, 1961 DETAILS OF EAST ENTABLATURE. - Hill County Courthouse, Public Squre, Waco, Elm, Covington & Franklin Streets, Hillsboro, Hill County, TX

Use of a consumer market activity monitoring and feedback device improves exercise capacity and activity levels in COPD.

PubMed

Caulfield, Brian; Kaljo, Indira; Donnelly, Seamas

2014-01-01

COPD is associated with a gradual decline in physical activity, which itself contributes to a worsening of the underlying condition. Strategies that improve physical activity levels are critical to halt this cycle. Wearable sensor based activity monitoring and persuasive feedback might offer a potential solution. However it is not clear just how much intervention might be needed in this regard - i.e. whether programmes need to be tailored specifically for the target clinical population or whether more simple activity monitoring and feedback solutions, such as that offered in consumer market devices, might be sufficient. This research was carried out to investigate the impact of 4 weeks of using an off the shelf consumer market activity monitoring and feedback application on measures of physical activity, exercise capacity, and health related quality of life in a population of 10 Stage I and II COPD patients. Results demonstrate a significant and positive effect on exercise capacity (measured using a 6-minute walk test) and activity levels (measured in terms of average number of steps per hour) yet no impact on health related quality of life (St Georges Respiratory Disease Questionnaire).

George Leonard's View of the Computer in Education.

ERIC Educational Resources Information Center

Bork, Alfred

Relatively few individuals have attempted to view the future of computers in education, and those who have done so often tend to focus too much upon present capabilities rather than thinking about the changes that new technology will introduce in the future. George Leonard's book "Education and Ecstasy" provides an interesting picture of…

12. August, 1970 DETAIL FRONT PORCH OF GEORGE B. GARDNER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. August, 1970 DETAIL FRONT PORCH OF GEORGE B. GARDNER HOUSE, 23 ORANGE STREET - Pierce, Easton, Russell, Bunker, & Gardner Houses, 15, 17, 19, 21 & 23 Orange Street, Nantucket, Nantucket County, MA

3. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 FIRST FLOOR, FRONT ROOM, FIREPLACE IN SOUTHEAST CORNER - Joseph Carleton House, 1052-54 Potomac Street Northwest, Washington, District of Columbia, DC

THE ONEIRIC AUTOBIOGRAPHY OF GEORGES PEREC.

PubMed

Schwartz, Henry P

2016-01-01

Georges Perec's book La Boutique Obscure (1973; translated into English in 2012) serves as the basis for this paper. The book is a collection of dreams that its author dreamed from May 1968 to August 1972. The present author treats these dreams as chapters in a bizarre autobiography, elaborating Perec's life through a discussion of those dreams and using them as a starting point with which to discuss his views of dream interpretation and the role of dreams in psychoanalysis. © 2016 The Psychoanalytic Quarterly, Inc.

The Rhetorical Theories of George Campbell and Kenneth Burke.

ERIC Educational Resources Information Center

Gannon, Craig A.

Points of similarity exist between rhetorical theorists George Campbell and Kenneth Burke, based on their acceptance of the universality of human nature. These similarities include the following: both use "strategic" definitions of rhetoric that are widely encompassing; Burke's central doctrine of "identification" resembles…

Taking precautions at KSC for Hurricane Georges

NASA Technical Reports Server (NTRS)

1998-01-01

Workers put up plywood barriers on the windows of the Operations Support Building (OSB) as part of a precautionary plan in the event that Hurricane Georges threatens Central Florida. In light of the unpredictable nature of hurricanes, the decision was made to minimize risk and provide protection to KSC personnel and to the Space Shuttle national asset. The Vehicle Assembly Building is reflected (left) in the uncovered windows of the OSB.

Continuous monitoring of Mount St. Helens Volcano

USGS Publications Warehouse

Spall, H.

1980-01-01

Day by day monitoring of the Mount St. Helens Volcano. These are four scenarios, very different scenarios, that can occur in a average week at Mount St. Helens. Ranging from eruptions of gas and to steam to eruptions of ash and pyroclastic flows to even calm days. This example of monitoring illustrates the differences from day to day volcanic activities at Mount St. Helens. 

6. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 BASEMENT: FIREPLACE SUPPORT ARCH, WEST WALL, UNDER BRICK ELL - Adams-Mason House, 1072 Thomas Jefferson Street Northwest, Washington, District of Columbia, DC

12. Photocopy of sketch (original in possession of WACC) George ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Photocopy of sketch (original in possession of WACC) George Dunn, photographer, 1892 'ORIGINAL HOME OF MR. AND MRS. NEIL ERICKSON IN BONITA CANYON ABOUT 1892' - Faraway Ranch, Willcox, Cochise County, AZ

Wastewater characterization survey, Victor Valley Wastewater Reclamation Authority and hazardous-waste survey at George AFB, California. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Binovi, R.D.; Ng, E.K.; Tetla, R.A.

1987-01-01

This is a report of a survey of the Victor Wastewater Reclamation Authority Sewerage system, the sewage treatment plant, and effluent from the various operations at George AFB, California. The scope of work included the characterization of the wastewater from George AFB, as well as characterization of effluents from 29 oil/water separators servicing industrial operations on base, flow measurements at three locations on base, a microbiological evaluation of aeration basin foam, bench-scale activated-sludge studies, and a review of results from previous surveys. Recommendations: (1) AFFF (Aqueous Film Forming Foam) should never be discharged to the sewer. (2) Programming for pretreatmentmore » should proceed at selected operations. (3) More waste and wastestream analysis be performed. (4) Upgrade waste accumulation points. (5) Implement an aggressive inspection program for oil/water separators. (6) Cut down on nonessential washing.« less

Mitochondria-associated Endoplasmic Reticulum Membrane (MAM) Regulates Steroidogenic Activity via Steroidogenic Acute Regulatory Protein (StAR)-Voltage-dependent Anion Channel 2 (VDAC2) Interaction*

PubMed Central

Prasad, Manoj; Kaur, Jasmeet; Pawlak, Kevin J.; Bose, Mahuya; Whittal, Randy M.; Bose, Himangshu S.

2015-01-01

Steroid hormones are essential for carbohydrate metabolism, stress management, and reproduction and are synthesized from cholesterol in mitochondria of adrenal glands and gonads/ovaries. In acute stress or hormonal stimulation, steroidogenic acute regulatory protein (StAR) transports substrate cholesterol into the mitochondria for steroidogenesis by an unknown mechanism. Here, we report for the first time that StAR interacts with voltage-dependent anion channel 2 (VDAC2) at the mitochondria-associated endoplasmic reticulum membrane (MAM) prior to its translocation to the mitochondrial matrix. In the MAM, StAR interacts with mitochondrial proteins Tom22 and VDAC2. However, Tom22 knockdown by siRNA had no effect on pregnenolone synthesis. In the absence of VDAC2, StAR was expressed but not processed into the mitochondria as a mature 30-kDa protein. VDAC2 interacted with StAR via its C-terminal 20 amino acids and N-terminal amino acids 221–229, regulating the mitochondrial processing of StAR into the mature protein. In the absence of VDAC2, StAR could not enter the mitochondria or interact with MAM-associated proteins, and therefore steroidogenesis was inhibited. Furthermore, the N terminus was not essential for StAR activity, and the N-terminal deletion mutant continued to interact with VDAC2. The endoplasmic reticulum-targeting prolactin signal sequence did not affect StAR association with the MAM and thus its mitochondrial targeting. Therefore, VDAC2 controls StAR processing and activity, and MAM is thus a central location for initiating mitochondrial steroidogenesis. PMID:25505173

Roegneria alashanica Keng: a species with the StStStYStY genome constitution.

PubMed

Wang, Richard R-C; Jensen, Kevin B

2017-06-01

The genome constitution of tetraploid Roegneria alashanica Keng has been in question for a long time. Most scientific studies have suggested that R. alashanica had two versions of the St genome, St 1 St 2 , similar to that of Pseudoroegneria elytrigioides (C. Yen & J.L. Yang) B.R. Lu. A study, however, concluded that R. alashanica had the StY genome formula typical for tetraploid species of Roegneria. For the present study, R. alashanica, Elymus longearistatus (Bioss.) Tzvelev (StY genomes), Pseudoroegneria strigosa (M. Bieb.) Á. Löve (St), Pseudoroegneria libanoctica (Hackel) D.R. Dewey (St), and Pseudoroegneria spicata (Pursh) Á. Löve (St) were screened for the Y-genome specific marker B14(F+R) 269 . All E. longearistatus plants expressed intense bands specific to the Y genome. Only 6 of 10 R. alashanica plants exhibited relatively faint bands for the STS marker. Previously, the genome in species of Pseudoroegneria exhibiting such faint Y-genome specific marker was designated as St Y . Based on these results, R. alashanica lacks the Y genome in E. longearistatus but likely possess two remotely related St genomes, St and St Y . According to its genome constitution, R. alashanica should be classified in the genus Pseudoroenera and given the new name Pseudoroegneria alashanica (Keng) R.R.-C. Wang and K.B. Jensen.

Pedagogical progeniture or tactical translation? George Fordyce's additions and modifications to William Cullen's philosophical chemistry--Part I.

PubMed

Taylor, Georgette

2014-02-01

This article contributes to a growing body of research on the dissemination, dispersion or diffusion of scientific knowledge via pedagogical networks. By examining students' handwritten lecture notes, I compare the eighteenth-century chemistry lectures given by William Cullen (1710-1790) at Glasgow and Edinburgh Universities with those of his one-time student George Fordyce (1736-1802), in London, at first privately and then as part of the medical education of physicians at St. Thomas's Hospital. Part I examines the broad structure of Cullen's and Fordyce's courses, comparing both course content and pedagogical approaches to ask how far knowledge flowed directly 'downstream,' and the extent to which it was transformed, translated or transmuted in the process of transmission. Part II (forthcoming) will approach the affinity theories of Cullen and Fordyce in greater depth, revealing the dynamics of knowledge transfer. The results shed light on the transmission of knowledge and skills between master and student, and reflect on whether Fordyce can be better described as Cullen's pedagogical progeny, or less straightforwardly as a tactical translator.

Dundee Canal Industrial Historic District, Beginning at George Street in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Dundee Canal Industrial Historic District, Beginning at George Street in Passaic & extending north along Dundee Canal approximately 1.2 miles to Canal headgates opposite East Clifton Avenue in Clifton, Passaic, Passaic County, NJ

Electrical activity during the 2006 Mount St. Augustine volcanic eruptions

USGS Publications Warehouse

Thomas, Ronald J.; Krehbiel, Paul R.; Rison, William; Edens, H. E.; Aulich, G. D.; McNutt, S.R.; Tytgat, Guy; Clark, E.

2007-01-01

By using a combination of radio frequency time-of-arrival and interferometer measurements, we observed a sequence of lightning and electrical activity during one of Mount St. Augustine's eruptions. The observations indicate that the electrical activity had two modes or phases. First, there was an explosive phase in which the ejecta from the explosion appeared to be highly charged upon exiting the volcano, resulting in numerous apparently disorganized discharges and some simple lightning. The net charge exiting the volcano appears to have been positive. The second phase, which followed the most energetic explosion, produced conventional-type discharges that occurred within plume. Although the plume cloud was undoubtedly charged as a result of the explosion itself, the fact that the lightning onset was delayed and continued after and well downwind of the eruption indicates that in situ charging of some kind was occurring, presumably similar in some respects to that which occurs in normal thunderstorms.

Social Reconstructionist Philosophy of Education and George S. Counts: Observations on the Ideology of Indoctrination in Socio-Critical Educational Thinking

ERIC Educational Resources Information Center

Sutinen, Ari

2014-01-01

This article comprises three parts: The author first outlines the principles of the social reconstructionist philosophy of education related to educational activity and social philosophy. After this, he describes the educational philosophy of George S. Counts, the most important developer of the social reconstructionist philosophy of education,…

George F. Root's Normal Musical Institute, 1853-1885

ERIC Educational Resources Information Center

Hash, Phillip M.

2012-01-01

George F. Root, Lowell Mason, and William B. Bradbury opened the New York Normal Musical Institute in April of 1853 in New York City. Each term lasted about three months and provided the first long-term preparation program for singing-school masters, church choir directors, private instructors, and school music teachers in the United States.…

Pragmatism, Activism, and the Icy Slopes of Logic in George Reisch's Portrait of the Philosophy of Science as a Young Field

ERIC Educational Resources Information Center

Stump, David J.

2009-01-01

This paper considers several models of politically engaged philosophy with the aim of provoking discussion of George Reisch's "How the Cold War Transformed Philosophy of Science." At issue is the Unity of Science movement's conception of the philosophy of science in particular and what politically engaged philosophy of science might look…

Stimulation of StAR expression by cAMP is controlled by inhibition of highly inducible SIK1 via CRTC2, a co-activator of CREB.

PubMed

Lee, Jinwoo; Tong, Tiegang; Takemori, Hiroshi; Jefcoate, Colin

2015-06-15

In mouse steroidogenic cells the activation of cholesterol metabolism is mediated by steroidogenic acute regulatory protein (StAR). Here, we visualized a coordinated regulation of StAR transcription, splicing and post-transcriptional processing, which are synchronized by salt inducible kinase (SIK1) and CREB-regulated transcription coactivator (CRTC2). To detect primary RNA (pRNA), spliced primary RNA (Sp-RNA) and mRNA in single cells, we generated probe sets by using fluorescence in situ hybridization (FISH). These methods allowed us to address the nature of StAR gene expression and to visualize protein-nucleic acid interactions through direct detection. We show that SIK1 represses StAR expression in Y1 adrenal and MA10 testis cells through inhibition of processing mediated by CRTC2. Digital image analysis matches qPCR analyses of the total cell culture. Evidence is presented for spatially separate accumulation of StAR pRNA and Sp-RNA at the gene loci in the nucleus. These findings establish that cAMP, SIK and CRTC mediate StAR expression through activation of individual StAR gene loci. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

55. Historic American Buildings Survey, George A. Eisenman, Photographer, 1969 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

55. Historic American Buildings Survey, George A. Eisenman, Photographer, 1969 DETAIL VIEW INTO BAKE OVEN IN THE SOUTHWEST CASEMATE OF THE EAST BASTION. - Fort Mifflin, Mud Island, Marine & Penrose Ferry Roads, Philadelphia, Philadelphia County, PA

2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline

PubMed Central

Chan, Wai Kit; Howe, Katherine; Clegg, James M.; Guimond, Scott E.; Price, David J.; Turnbull, Jeremy E.; Pratt, Thomas

2015-01-01

Heparan sulfate (HS) is a linear carbohydrate composed of polymerized uronate-glucosamine disaccharide units that decorates cell surface and secreted glycoproteins in the extracellular matrix. In mammals HS is subjected to differential sulfation by fifteen different heparan sulfotransferase (HST) enzymes of which Hs2st uniquely catalyzes the sulfation of the 2-O position of the uronate in HS. HS sulfation is postulated to be important for regulation of signaling pathways by facilitating the interaction of HS with signaling proteins including those of the Fibroblast Growth Factor (Fgf) family which signal through phosphorylation of extracellular signal-regulated kinases Erk1/2. In the developing mouse telencephalon Fgf2 signaling regulates proliferation and neurogenesis. Loss of Hs2st function phenocopies the thinned cerebral cortex of mutant mice in which Fgf2 or Erk1/2 function are abrogated, suggesting the hypothesis that 2-O-sulfated HS structures play a specific role in Fgf2/Erk signaling pathway in this context in vivo. This study investigated the molecular role of 2-O sulfation in Fgf2/Erk signaling in the developing telencephalic midline midway through mouse embryogenesis at E12.5. We examined the expression of Hs2st, Fgf2, and Erk1/2 activity in wild-type and Hs2st-/- mice. We found that Hs2st is expressed at high levels at the midline correlating with high levels of Erk1/2 activation and Erk1/2 activation was drastically reduced in the Hs2st-/- mutant at the rostral telencephalic midline. We also found that 2-O sulfation is specifically required for the binding of Fgf2 protein to Fgfr1, its major cell-surface receptor at the rostral telencephalic midline. We conclude that 2-O sulfated HS structures generated by Hs2st are needed to form productive signaling complexes between HS, Fgf2 and Fgfr1 that activate Erk1/2 at the midline. Overall, our data suggest the interesting possibility that differential expression of Hs2st targets the rostral telencephalic

Prescient … and Not Always Accounted For: The Wisdom and Foresight of George A. Roeper

ERIC Educational Resources Information Center

Delisle, Jim; Ruff, Marcia

2016-01-01

When George A. Roeper enlisted the aid of Dr. A. Harry Passow and other leaders in the field to help George convert his Michigan independent school to focus on gifted children in 1956, there was only one other elementary school in the country at the time devoted exclusively to gifted child education. Though his wife and school cofounder,…

52. Historic American Buildings Survey, George A. Eisenman, Photographer, 1969 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

52. Historic American Buildings Survey, George A. Eisenman, Photographer, 1969 DETAIL VIEW OF THE BAKE OVENS OF THE SOUTHWEST CASEMATE OF THE EAST BASTION. - Fort Mifflin, Mud Island, Marine & Penrose Ferry Roads, Philadelphia, Philadelphia County, PA

Mitochondria-associated endoplasmic reticulum membrane (MAM) regulates steroidogenic activity via steroidogenic acute regulatory protein (StAR)-voltage-dependent anion channel 2 (VDAC2) interaction.

PubMed

Prasad, Manoj; Kaur, Jasmeet; Pawlak, Kevin J; Bose, Mahuya; Whittal, Randy M; Bose, Himangshu S

2015-01-30

Steroid hormones are essential for carbohydrate metabolism, stress management, and reproduction and are synthesized from cholesterol in mitochondria of adrenal glands and gonads/ovaries. In acute stress or hormonal stimulation, steroidogenic acute regulatory protein (StAR) transports substrate cholesterol into the mitochondria for steroidogenesis by an unknown mechanism. Here, we report for the first time that StAR interacts with voltage-dependent anion channel 2 (VDAC2) at the mitochondria-associated endoplasmic reticulum membrane (MAM) prior to its translocation to the mitochondrial matrix. In the MAM, StAR interacts with mitochondrial proteins Tom22 and VDAC2. However, Tom22 knockdown by siRNA had no effect on pregnenolone synthesis. In the absence of VDAC2, StAR was expressed but not processed into the mitochondria as a mature 30-kDa protein. VDAC2 interacted with StAR via its C-terminal 20 amino acids and N-terminal amino acids 221-229, regulating the mitochondrial processing of StAR into the mature protein. In the absence of VDAC2, StAR could not enter the mitochondria or interact with MAM-associated proteins, and therefore steroidogenesis was inhibited. Furthermore, the N terminus was not essential for StAR activity, and the N-terminal deletion mutant continued to interact with VDAC2. The endoplasmic reticulum-targeting prolactin signal sequence did not affect StAR association with the MAM and thus its mitochondrial targeting. Therefore, VDAC2 controls StAR processing and activity, and MAM is thus a central location for initiating mitochondrial steroidogenesis. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Retreat of northern margins of George VI and Wilkins Ice Shelves, Antarctic Peninsula

USGS Publications Warehouse

Lucchitta, B.K.; Rosanova, C.E.

1998-01-01

The George VI and Wilkins Ice Shelves are considered at risk of disintegration due to a regional atmospheric warming trend on the Antarctic Peninsula. Retreat of the northern margin of the George VI Ice Shelf has been observed previously, but the Wilkins Ice Shelf was thought to be stable. We investigated the positions of the northern fronts of these shelves from the literature and looked for changes on 1974 Landsat and 1992 and 1995 European remote-sensing satellite (ERS) synthetic aperture radar images. Our investigation shows that the northern George VI Ice Shelf lost a total of 906 km2 between 1974 and 1992, and an additional 87 km2 by 1995. The northern margin of the Wilkins Ice Shelf lost 796 km2 between 1990 and 1992, and another 564 km2 between 1992 and 1995. Armadas of tabular icebergs were visible in front of this shelf in the ERS images. These two ice shelves mark the southernmost documented conspicuous retreat of ice-shelf margins.

Airborne Radar Observations of Hurricane Georges during Landfall over the Dominican Republic

NASA Technical Reports Server (NTRS)

Geerts, B.; Heymsfield, G.; Tian, L.

1999-01-01

On 22 September 1998 hurricane Georges made landfall on the Dominican Republic (DR). Georges cost the DR at least 500 lives, made more than 155,000 people homeless and caused extensive damage to the country's main industries, tourism and agriculture. There was considerable wind damage, with wind gusts up to 58 m/s in Santa Domingo on the south coast, but most of the damage and deaths resulted from mudslides and the flooding of rivers. While this may have been the worst natural disaster to strike the DR, the sustained rapid storm movement saved the island from worse damage. Georges had previously affected several islands in the Lesser Antilles and Puerto Rico, but it had retained much of its circulation strength. Forty raingauge stations across the DR measured rainfall totals from Georges between 0.7 and 41 cm, the latter at the capital Santo Domingo, located on the south coast. At Herrera the maximum 1 h rainfall rate was 72 mm/h. It is suspected that much higher rain rates occurred in DR's mountainous interior. Before landfall the eye was clearly evident in satellite imagery. When the eye moved over southeastern DR, it filled rapidly, and the cloud top height decreased in all storm sectors except in the southern inflow sector, where a long-lived MCS, with a diameter larger than that of the eyewall, slowly became enwrapped in the hurricane circulation. The eye closure was most rapid between 16-18 UTC, when the eyewall circulation felt the mountainous terrain of the Cordillera Central, which rises up to 3,093 m. The estimated central pressure increased from 962 hPa at 15 UTC to 986 hPa at 03Z on 23 Sept, and the maximum sustained surface wind speed decreased from 54 to 36 in s-1 during the same period. The island of Hispaniola has a cross-track width of about 250 km, much wider than the diameter of the eyewall anvil (about 100 km before landfall). So the event can truly be considered to be a landfalling case, even though Georges recovered after crossing Hispaniola

George Henry Hepting: Pioneer Leader in Forest Pathology

Treesearch

Ellis B. Cowling; Arthur Kelman; Harry R. Powers

1999-01-01

George Henry Hepting grew up in the city environment of Brooklyn, but early in his life developed a deep love and scientific interest in forestry. He became America's most skilled scientist in the theory and practice of forest pathology. He studied how long-lived forest trees, unlike most plants, cope with the long-term changes in their biological, physical, and...

George Hoyt Whipple and the Impact of Liver on Anemia

Science.gov Websites

Nobel Prize for his discovery that liver fed to anemic dogs reverses the effects of the anemia. This Effects of Ionizing Radiation Cycle, DOE Technical Report, 1952 Top Additional Web Pages: George H

76 FR 38419 - United States v. George's Foods, LLC, et. al.; Proposed Final Judgment and Competitive Impact...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-30

...'s'') Harrisonburg, Virginia chicken processing complex, consummated May 7, 2011, violated Section 7... acquisition of Tyson Foods, Inc.'s (``Tyson's'') Harrisonburg, Virginia chicken processing complex..., when Tyson and George's publicly announced George's intent to buy Tyson's Harrisonburg chicken...

Transcriptional activation of LON Gene by a new form of mitochondrial stress: A role for the nuclear respiratory factor 2 in StAR overload response (SOR).

PubMed

Bahat, Assaf; Perlberg, Shira; Melamed-Book, Naomi; Isaac, Sara; Eden, Amir; Lauria, Ines; Langer, Thomas; Orly, Joseph

2015-06-15

High output of steroid hormone synthesis in steroidogenic cells of the adrenal cortex and the gonads requires the expression of the steroidogenic acute regulatory protein (StAR) that facilitates cholesterol mobilization to the mitochondrial inner membrane where the CYP11A1/P450scc enzyme complex converts the sterol to the first steroid. Earlier studies have shown that StAR is active while pausing on the cytosolic face of the outer mitochondrial membrane while subsequent import of the protein into the matrix terminates the cholesterol mobilization activity. Consequently, during repeated activity cycles, high level of post-active StAR accumulates in the mitochondrial matrix. To prevent functional damage due to such protein overload effect, StAR is degraded by a sequence of three to four ATP-dependent proteases of the mitochondria protein quality control system, including LON and the m-AAA membranous proteases AFG3L2 and SPG7/paraplegin. Furthermore, StAR expression in both peri-ovulatory ovarian cells, or under ectopic expression in cell line models, results in up to 3-fold enrichment of the mitochondrial proteases and their transcripts. We named this novel form of mitochondrial stress as StAR overload response (SOR). To better understand the SOR mechanism at the transcriptional level we analyzed first the unexplored properties of the proximal promoter of the LON gene. Our findings suggest that the human nuclear respiratory factor 2 (NRF-2), also known as GA binding protein (GABP), is responsible for 88% of the proximal promoter activity, including the observed increase of transcription in the presence of StAR. Further studies are expected to reveal if common transcriptional determinants coordinate the SOR induced transcription of all the genes encoding the SOR proteases. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Improvements to the George/Castillo Boundary Layer Theory

NASA Astrophysics Data System (ADS)

Wosnik, Martin; George, William K.; Castillo, Luciano

2000-11-01

George and Castillo (1997)(George WK and Castillo L (1997) Appl.Mech.Rev.), 50, 12/1, 689-729. presented a new theory for Zero Pressure Gradient Turbulent Boundary Layers based on an application of Near-Asymptotics to scaling laws derived from equilibrium similarity to the Reynolds-averaged equations. The resulting overlap velocity profiles retained a dependence on local Reynolds number, the parameters for which had to satisfy the following constraint equation: ln \\varepsilon fracdγd ln δ^+ = fracdln [C_o/C_i] d ln δ^+ where γ is the power exponent, Co and Ci are the coefficients in inner and outer variables respectively. GC considered only the first term in an asymptotic expansion of the exact solution, but higher order terms can be considered with no increase in the number of unknowns. The improved theory is tested against new experimental Zero Pressure Gradient Turbulent Boundary Layer data of Smith (1994), Oesterlund (1999) and Johansson and Castillo (2000). For the friction law, the first order term is sufficient, but for Co and γ the higher order terms improve the fit to the velocity profiles significantly.

St. Louis Area Earthquake Hazards Mapping Project

USGS Publications Warehouse

Williams, Robert A.; Steckel, Phyllis; Schweig, Eugene

2007-01-01

St. Louis has experienced minor earthquake damage at least 12 times in the past 200 years. Because of this history and its proximity to known active earthquake zones, the St. Louis Area Earthquake Hazards Mapping Project will produce digital maps that show variability of earthquake hazards in the St. Louis area. The maps will be available free via the internet. They can be customized by the user to show specific areas of interest, such as neighborhoods or transportation routes.

Dr. George Koob: "Alcohol Use Disorders Are a Major Problem..."

MedlinePlus

... 662-HELP (4357) or the Substance Abuse Treatment Facility Locator, an online, searchable directory of alcohol and drug abuse programs located around the country. Read More "Rethinking Drinking" Articles Rethinking Drinking / The Importance of Drinking Patterns / Dr. George Koob: "Alcohol use ...

2. Photocopy of photoengraving illustration in George T. Clark, Leland ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Photocopy of photo-engraving illustration in George T. Clark, Leland Stanford, War Governor . . . , Stanford, Calif., Stanford University Press, 1931, p. 114. NORTHWEST CORNER OF THE HOUSE PRIOR TO 1870 - Leland Stanford House, 800 N Street, Sacramento, Sacramento County, CA

29. ORE DOCK, LOOKING WEST; AT WORK UNLOADING THE 'GEORGE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. ORE DOCK, LOOKING WEST; AT WORK UNLOADING THE 'GEORGE M. HUMPHREY'S' CARGO OF 25,000. TONS OF ORE. - Pennsylvania Railway Ore Dock, Lake Erie at Whiskey Island, approximately 1.5 miles west of Public Square, Cleveland, Cuyahoga County, OH

Impact of human-associated Escherichia coli clonal groups in Antarctic pinnipeds: presence of ST73, ST95, ST141 and ST131.

PubMed

Mora, Azucena; García-Peña, Francisco Javier; Alonso, María Pilar; Pedraza-Diaz, Susana; Ortega-Mora, Luis Miguel; Garcia-Parraga, Daniel; López, Cecilia; Viso, Susana; Dahbi, Ghizlane; Marzoa, Juan; Sergeant, Martin J; García, Vanesa; Blanco, Jorge

2018-03-16

There is growing concern about the spreading of human microorganisms in relatively untouched ecosystems such as the Antarctic region. For this reason, three pinniped species (Leptonychotes weddellii, Mirounga leonina and Arctocephalus gazella) from the west coast of the Antartic Peninsula were analysed for the presence of Escherichia spp. with the recovery of 158 E. coli and three E. albertii isolates. From those, 23 harboured different eae variants (α1, β1, β2, ε1, θ1, κ, ο), including a bfpA-positive isolate (O49:H10-A-ST206, eae-k) classified as typical enteropathogenic E. coli. Noteworthy, 62 of the 158 E. coli isolates (39.2%) exhibited the ExPEC status and 27 (17.1%) belonged to sequence types (ST) frequently occurring among urinary/bacteremia ExPEC clones: ST12, ST73, ST95, ST131 and ST141. We found similarities >85% within the PFGE-macrorrestriction profiles of pinniped and human clinic O2:H6-B2-ST141 and O16:H5/O25b:H4-B2-ST131 isolates. The in silico analysis of ST131 Cplx genomes from the three pinnipeds (five O25:H4-ST131/PST43-fimH22-virotype D; one O16:H5-ST131/PST506-fimH41; one O25:H4-ST6252/PST9-fimH22-virotype D1) identified IncF and IncI1 plasmids and revealed high core-genome similarities between pinniped and human isolates (H22 and H41 subclones). This is the first study to demonstrate the worrisome presence of human-associated E. coli clonal groups, including ST131, in Antarctic pinnipeds.

Chemistry of St. John's Wort: Hypericin and Hyperforin

NASA Astrophysics Data System (ADS)

Vollmer, John J.; Rosenson, Jon

2004-10-01

St. John's wort is a common plant that has been used medicinally for over 20 centuries. This herb is currently used by millions of people, primarily as natural antidepressant; yet, its efficacy is still under constant debate. St. John's wort contains a large aromatic molecule, hypericin, twisted by steric interactions into the shape of a propeller. For use as antidepressant, St. John's wort is standardized to the content of hypericin, but this molecule was recently found not to be the active ingredient. A totally different bicyclic molecule with complex substitution pattern, hyperforin, was then studied as the causative agent. Both molecules are strongly active in biological systems. Hypericin has shown antiviral activity and is a potent natural photosensitizer that has been used in photodynamic therapy against cancer and against HIV in stored blood. Hyperforin was found to activate a particular receptor in the liver that induces the production of an enzyme used for the metabolism of medications. This effect causes more rapid breakdown of many prescription medications and can interfere with their effectiveness. This finding should prompt a reevaluation of regular use of St. John's wort.

George Orwell's Animal Farm: a case study in leadership/management for undergraduate nursing students.

PubMed

Metcalf, James A

2005-07-01

Many BSN curricula require a "leadership and management" course. At George Mason University, that course is Leadership and Management in Nursing and Health Science. This article describes how George Orwell's classic novel Animal Farm was used as a case study in leadership and management. This exercise complemented the traditional course material, united the class in a common intellectual exercise, and fostered creative thinking. A nursing student, Anne Lord, offers reaction to the assignment as a signed "In-Box" exemplar.

Three-dimensional velocity models of the Mount St. Helens magmatic system using the iMUSH active-source data set

NASA Astrophysics Data System (ADS)

Kiser, E.; Levander, A.; Zelt, C. A.; Palomeras, I.; Creager, K.; Ulberg, C. W.; Schmandt, B.; Hansen, S. M.; Harder, S. H.; Abers, G. A.; Crosbie, K.

2017-12-01

Building upon previously published 2D results, this presentation will show the first 3D velocity models down to the Moho using the iMUSH (imaging Magma Under St. Helens) active-source seismic data set. Direct P and S wave travel times from 23 borehole shots recorded at approximately 6000 seismograph locations are used to model Vp, Vs, and Vp/Vs over an area extending approximately 75 km from the edifice of Mount St. Helens and down to approximately 15 km depth. At shallow depths, results show several high and low velocity anomalies that correspond well with known geological features. These include the Chehalis Basin northwest of Mount St. Helens, and the Silver Star Mountain, Spirit Lake, and Spud Mountain plutons. Starting at 4 km depth, low velocities and high Vp/Vs values are observed near Mount St. Helens, which may be associated with shallow magmatic fluids. High Vp/Vs values are also observed beneath the Indian Heaven Volcanic Field southeast of Mount St. Helens. At the regional scale, high amplitude north/south trending low and high velocity features extend from the western margin of the resolved models to approximately 30 km west of Mount St. Helens. In general these high and low velocity features also correspond to high and low Vp/Vs anomalies, respectively. These results are in agreement with previous studies that conclude that the accreted terrane Siletzia is composed of multiple igneous bodies interspersed with sedimentary units in this region. Another regional feature of interest is a broad low Vp/Vs area between Mount St. Helens, Mount Adams, and Mount Rainier that spatially correlates with the Southern Washington Cascades Conductor, indicating a non-magmatic origin to this body at shallow and mid-crustal depths. In addition to these shallow results, preliminary 3D velocity models of the entire crust will be presented that utilize both direct and reflected seismic phases from the Moho and other mid-crustal discontinuities. These models will constrain

78 FR 44927 - 101st Commission Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-25

... ARCTIC RESEARCH COMMISSION 101st Commission Meeting Notice is hereby given that the U.S. Arctic Research Commission will hold its 101st meeting in Unalaska, Alaska, on August 26-27, 2013. The business... and staff reports (4) Discussion and presentations concerning Arctic research activities The focus of...

The Rhetoric of the Challenger: George Stanley McGovern.

ERIC Educational Resources Information Center

Trent, Judith S.; Trent, Jimmie D.

Reasons for George McGovern's presidential election failure are summarized in the context of McGovern's rhetoric as a challenger. Taking the point of view that McGovern abandoned the traditional rhetorical advantages of the challenger, the authors conclude that this abandonment along with the problems of financing, the impression of alignment with…

2017 Total Eclipse Viewing Tips - Narrated by George Takei

NASA Image and Video Library

2017-08-09

On Monday, August 21, 2017, all of North America will be treated to an eclipse of the sun. Anyone within the path of totality can see one of nature’s most awe inspiring sights - a total solar eclipse. This video, narrated by actor George Takei, provides a few viewing tips for the public.

Correlation of Gerkin, Queen's College, George, and Jackson methods in estimating maximal oxygen consumption.

PubMed

Heydari, Payam; Varmazyar, Sakineh; Variani, Ali Safari; Hashemi, Fariba; Ataei, Seyed Sajad

2017-10-01

Test of maximal oxygen consumption is the gold standard for measuring cardio-pulmonary fitness. This study aimed to determine correlation of Gerkin, Queen's College, George, and Jackson methods in estimating maximal oxygen consumption, and demographic factors affecting maximal oxygen consumption. This descriptive cross-sectional study was conducted in a census of medical emergency students (n=57) in Qazvin University of Medical Sciences in 2016. The subjects firstly completed the General Health Questionnaire (PAR-Q) and demographic characteristics. Then eligible subjects were assessed using exercise tests of Gerkin treadmill, Queen's College steps and non-exercise George, and Jackson. Data analysis was carried out using independent t-test, one way analysis of variance and Pearson correlation in the SPSS software. The mean age of participants was 21.69±4.99 years. The mean of maximal oxygen consumption using Gerkin, Queen's College, George, and Jackson tests was 4.17, 3.36, 3.64, 3.63 liters per minute, respectively. Pearson statistical test showed a significant correlation among fours tests. George and Jackson tests had the greatest correlation (r=0.85, p>0.001). Results of tests of one-way analysis of variance and t-test showed a significant relationship between independent variable of weight and height in four tests, and dependent variable of maximal oxygen consumption. Also, there was a significant relationship between variable of body mass index in two tests of Gerkin and Queen's College and variable of exercise hours per week with the George and Jackson tests (p>0.001). Given the obtained correlation, these tests have the potential to replace each other as necessary, so that the non-exercise Jackson test can be used instead of the Gerkin test.

An interview with George Daley.

PubMed

Maartens, Aidan

2017-09-15

George Daley is Dean of the Faculty of Medicine, Professor of Biological Chemistry and Molecular Pharmacology, and Caroline Shields Walker Professor of Medicine at Harvard Medical School. A former Howard Hughes Medical Institute Investigator and President of the International Society for Stem Cell Research (ISSCR) from 2007-2008, his lab works on the biology and clinical application of stem cells, with a particular focus on hematopoiesis. He was awarded the Public Service Award at the ISSCR 2017 meeting in Boston, where we caught up with him to discuss his move from the lab to the clinic and back again, his quest to derive human hematopoietic stem cells in vitro , and his advocacy for science in uncertain political times. © 2017. Published by The Company of Biologists Ltd.

Learning from eponyms: George F. Odland and Odland bodies

PubMed Central

Joshi, Rajiv

2014-01-01

Odland bodies (lamellar) bodies are small sub-cellular structures of size 200-300 nm that are present in the upper spinous and granular cell layers of the epidermis. These act as processing and repository areas for lipids that contribute to the epidermal permeability barrier. They also contain proteases, cathepsin D, kallikrein and other proteins including corneo-desmosins. Recent information also credits them with a role in the local innate immune response as they contain beta 2 defensins, which are anti-microbial peptides with potent activity against Gram-negative bacteria and candida. Odland bodies are important for maintaining homeostasis of the epidermis and are involved in epidermal permeability barrier function, desquamation of keratinocytes, formation of the cornified envelope and in local anti-microbial immunity. This article reviews the structure and functions of these bodies with a brief biography of George F. Odland who first described these bodies in 1960 and whose name is eponymically associated with them. PMID:25165659

Reproducibility of CSF quantitative culture methods for estimating rate of clearance in cryptococcal meningitis.

PubMed

Dyal, Jonathan; Akampurira, Andrew; Rhein, Joshua; Morawski, Bozena M; Kiggundu, Reuben; Nabeta, Henry W; Musubire, Abdu K; Bahr, Nathan C; Williams, Darlisha A; Bicanic, Tihana; Larsen, Robert A; Meya, David B; Boulware, David R

2016-05-01

Quantitative cerebrospinal fluid (CSF) cultures provide a measure of disease severity in cryptococcal meningitis. The fungal clearance rate by quantitative cultures has become a primary endpoint for phase II clinical trials. This study determined the inter-assay accuracy of three different quantitative culture methodologies. Among 91 participants with meningitis symptoms in Kampala, Uganda, during August-November 2013, 305 CSF samples were prospectively collected from patients at multiple time points during treatment. Samples were simultaneously cultured by three methods: (1) St. George's 100 mcl input volume of CSF with five 1:10 serial dilutions, (2) AIDS Clinical Trials Group (ACTG) method using 1000, 100, 10 mcl input volumes, and two 1:100 dilutions with 100 and 10 mcl input volume per dilution on seven agar plates; and (3) 10 mcl calibrated loop of undiluted and 1:100 diluted CSF (loop). Quantitative culture values did not statistically differ between St. George-ACTG methods (P= .09) but did for St. George-10 mcl loop (P< .001). Repeated measures pairwise correlation between any of the methods was high (r≥0.88). For detecting sterility, the ACTG-method had the highest negative predictive value of 97% (91% St. George, 60% loop), but the ACTG-method had occasional (∼10%) difficulties in quantification due to colony clumping. For CSF clearance rate, St. George-ACTG methods did not differ overall (mean -0.05 ± 0.07 log10CFU/ml/day;P= .14) on a group level; however, individual-level clearance varied. The St. George and ACTG quantitative CSF culture methods produced comparable but not identical results. Quantitative cultures can inform treatment management strategies. © The Author 2016. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

33 CFR 334.760 - Naval Support Activity Panama City and Alligator Bayou, a tributary of St. Andrew Bay, Fla...

Code of Federal Regulations, 2011 CFR

2011-07-01

... City and Alligator Bayou, a tributary of St. Andrew Bay, Fla.; naval restricted area. 334.760 Section... DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.760 Naval Support Activity Panama City and... permission from the Officer in Charge, Naval Support Activity Panama City, Panama City Beach, Florida, or his...

33 CFR 334.760 - Naval Support Activity Panama City and Alligator Bayou, a tributary of St. Andrew Bay, Fla...

Code of Federal Regulations, 2010 CFR

2010-07-01

... City and Alligator Bayou, a tributary of St. Andrew Bay, Fla.; naval restricted area. 334.760 Section... DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.760 Naval Support Activity Panama City and... permission from the Officer in Charge, Naval Support Activity Panama City, Panama City Beach, Florida, or his...

Passive margins: U.S. Geological Survey Line 19 across the Georges Bank basin

USGS Publications Warehouse

Klitgord, Kim D.; Schlee, John S.; Grow, John A.; Bally, A.W.

1987-01-01

Georges Bank is a shallow part of the Atlantic continental shelf southeast of New England (Emery and Uchupi, 1972, 1984). This bank, however, is merely the upper surface of several sedimentary basins overlying a block-faulted basement of igneous and metamorphic crystalline rock. Sedimentary rock forms a seaward-thickening cover that has accumulated in one main depocenter and several ancillary depressions, adjacent to shallow basement platforms of paleozoic and older crystalline rock. Georges Bank basin contains a thickness of sedimentary rock greater than 10 km, whereas the basement platforms that flank the basin are areas of thin sediment accumulation (less than 5 km).

27 CFR 9.109 - Northern Neck George Washington Birthplace.

Code of Federal Regulations, 2010 CFR

2010-04-01

...; Virginia U.S.G.S. map at a point on Potomac Creek where the King George County western boundary line at its northermost point intersects Potomac Creek the boundary proceeds easterly and southeasterly on the Richmond, VA; MD. U.S.G.S. map, along the Virginia shoreline of the Potomac River for approximately 66 miles to...

27 CFR 9.109 - Northern Neck George Washington Birthplace.

Code of Federal Regulations, 2014 CFR

2014-04-01

...; Virginia U.S.G.S. map at a point on Potomac Creek where the King George County western boundary line at its northermost point intersects Potomac Creek the boundary proceeds easterly and southeasterly on the Richmond, VA; MD. U.S.G.S. map, along the Virginia shoreline of the Potomac River for approximately 66 miles to...

27 CFR 9.109 - Northern Neck George Washington Birthplace.

Code of Federal Regulations, 2012 CFR

2012-04-01

...; Virginia U.S.G.S. map at a point on Potomac Creek where the King George County western boundary line at its northermost point intersects Potomac Creek the boundary proceeds easterly and southeasterly on the Richmond, VA; MD. U.S.G.S. map, along the Virginia shoreline of the Potomac River for approximately 66 miles to...

27 CFR 9.109 - Northern Neck George Washington Birthplace.

Code of Federal Regulations, 2013 CFR

2013-04-01

...; Virginia U.S.G.S. map at a point on Potomac Creek where the King George County western boundary line at its northermost point intersects Potomac Creek the boundary proceeds easterly and southeasterly on the Richmond, VA; MD. U.S.G.S. map, along the Virginia shoreline of the Potomac River for approximately 66 miles to...

27 CFR 9.109 - Northern Neck George Washington Birthplace.

Code of Federal Regulations, 2011 CFR

2011-04-01

...; Virginia U.S.G.S. map at a point on Potomac Creek where the King George County western boundary line at its northermost point intersects Potomac Creek the boundary proceeds easterly and southeasterly on the Richmond, VA; MD. U.S.G.S. map, along the Virginia shoreline of the Potomac River for approximately 66 miles to...

[Physician from Constance doctor of medicine Georg Vogelin (1508-1542), an early follower of Copernicus].

PubMed

Burmeister, K H

1999-01-01

Georg Vogelin was born in Constance as the son of the town clerk. He studied the artes liberales and medicine at Wittenberg (since 1523) and Montpellier (since 1527). From 1531 onwards he practiced as a medical doctor in Constance. In 1542 Vogelin died of the plague in Constance. Vogelin was very close friends with the medical doctor Achilles Pirmin Gasser (1505-1577) and Georg Joachim Rheticus (1514-1574), a well known pupil of Copernicus. He was amongst the first supporters of the teachings of Copernicus. Gasser, who published the second edition of Rheticus' "Narratio prima" (Basle 1541), dedicated this edition to Georg Vogelin. In this book Vogelin published a poem in Latin. In the poem he described the teachings of Copernicus ("Terraque iam currit, credita stare prius") and recommended the academic community to approve Copernicus' theory.

Sand-wave movement on Little Georges Bank

USGS Publications Warehouse

Twichell, David C.

1983-01-01

A 1-x-1.5-km area on Little Georges Bank (centered at 41?08?N., 68?04?W.) was mapped three times during a ten-month period by sidescan sonar and echo-sounding techniques to assess the morphology and mobility of sand waves on Georges Bank. Sand-wave amplitudes in the survey area ranged from 1-11 m although most were 5-7 m. Wavelengths were not constant as the crests were sinuous and in places, even bifurcated. The sand waves are asymmetrical with their steepest sides facing northwest; however, gradients of their steep sides mostly are 4?-10? which is well below the angle of repose for sand in water. Sand waves tended to have greater relief and a sharper asymmetry during the survey in September than during those in June or April. During the survey period the sand waves moved but the direction and rate of motion was variable. Even along an individual sand wave some parts moved as much as 60 m between surveys while other parts apparently remained stationary. The sand waves were asymmetrical, but movement was not consistently in the direction that the steep sides faced. Along the same sand wave, parts moved to the northwest while other parts moved to the southeast. Despite the complex pattern of sand motion, the mean displacement of the sand waves was below the resolution of the survey technique; to resolve it, a longer survey is needed.

[Georg Schlöndorff-the father of computer-assisted surgery].

PubMed

Mösges, R

2016-09-01

Georg Schlöndorff (1931-2011) developed the idea of computer-assisted surgery (CAS) during his time as professor and chairman of the Department of Otorhinolaryngology at the Medical Faculty of the University of Aachen, Germany. In close cooperation with engineers and physicists, he succeeded in translating this concept into a functional prototype that was applied in live surgery in the operating theatre. The first intervention performed with this image-guided navigation system was a skull base surgical procedure 1987. During the following years, this concept was extended to orbital surgery, neurosurgery, mid-facial traumatology, and brachytherapy of solid tumors in the head and neck region. Further technical developments of this first prototype included touchless optical positioning and the computer vision concept with three orthogonal images, which is still common in contemporary navigation systems. During his time as emeritus professor from 1996, Georg Schlöndorff further pursued his concept of CAS by developing technical innovations such as computational fluid dynamics (CFD).

George E. KidderSmith, April 1945, Photograph #1338. VIEW OF BUILDING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

George E. Kidder-Smith, April 1945, Photograph #133-8. VIEW OF BUILDING 23, FRONT SIDE FROM ACROSS COURTYARD, FACING WEST - Roosevelt Base, Auditorium-Gymnasium, West Virginia Street between Richardson & Reeves Avenues, Long Beach, Los Angeles County, CA

George E. KidderSmith, photographer, April 1945, Photograph #1101. VIEW OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

George E. Kidder-Smith, photographer, April 1945, Photograph #110-1. VIEW OF BUILDING 23, SOUTH SIDE WITH ARCADE, FACING NORTHWEST - Roosevelt Base, Auditorium-Gymnasium, West Virginia Street between Richardson & Reeves Avenues, Long Beach, Los Angeles County, CA

Distribution of Anaerobic Hydrocarbon-Degrading Bacteria in Soils from King George Island, Maritime Antarctica.

PubMed

Sampaio, Dayanna Souza; Almeida, Juliana Rodrigues Barboza; de Jesus, Hugo E; Rosado, Alexandre S; Seldin, Lucy; Jurelevicius, Diogo

2017-11-01

Anaerobic diesel fuel Arctic (DFA) degradation has already been demonstrated in Antarctic soils. However, studies comparing the distribution of anaerobic bacterial groups and of anaerobic hydrocarbon-degrading bacteria in Antarctic soils containing different concentrations of DFA are scarce. In this study, functional genes were used to study the diversity and distribution of anaerobic hydrocarbon-degrading bacteria (bamA, assA, and bssA) and of sulfate-reducing bacteria (SRB-apsR) in highly, intermediate, and non-DFA-contaminated soils collected during the summers of 2009, 2010, and 2011 from King George Island, Antarctica. Signatures of bamA genes were detected in all soils analyzed, whereas bssA and assA were found in only 4 of 10 soils. The concentration of DFA was the main factor influencing the distribution of bamA-containing bacteria and of SRB in the analyzed soils, as shown by PCR-DGGE results. bamA sequences related to genes previously described in Desulfuromonas, Lautropia, Magnetospirillum, Sulfuritalea, Rhodovolum, Rhodomicrobium, Azoarcus, Geobacter, Ramlibacter, and Gemmatimonas genera were dominant in King George Island soils. Although DFA modulated the distribution of bamA-hosting bacteria, DFA concentration was not related to bamA abundance in the soils studied here. This result suggests that King George Island soils show functional redundancy for aromatic hydrocarbon degradation. The results obtained in this study support the hypothesis that specialized anaerobic hydrocarbon-degrading bacteria have been selected by hydrocarbon concentrations present in King George Island soils.

Family life and human development (sex education): the Prince George's County Public Schools experience.

PubMed

Schaffer, M J

1981-04-01

The Family Life and Human Development (Sex Education) program is now fully implemented in 99.5% of Prince George's County Public Schools. The program is credited with better than 98% parental acceptance and student participation. The administrative guidelines and program supervision are crucial to the program's success. The program was developed to be in compliance with the Maryland State Board of Education Bylaw 13.03.03.01 that requires that sex education be offered. Prior to program implementation, the guidelines were written, parents were involved, and teachers and administrators were trained. All instruction is organized around 3 areas of focus: interpersonal relationships; physiological and personality changes of puberty; and advanced physiology and psychology of human sexual behavior. The major limitation of the program is that in grades 9-12 when such subjects as contraception, abortion, homosexuality and premarital intercourse can be discussed, only a small percentage of the student population are able to enroll each year. The reason for the low percentage include lack of funds to hire additional teachers, limited time due to 1/2 day work/study teachers, and the elective classification of the program. Before a teacher is permitted to teach any aspect of the program that deals with the reproductive system or any potentially sensitive area of sexuality, he/she must 1st meet certain established criteria.

Ecosystem management: A comparison of greater yellowstone and georges bank

NASA Astrophysics Data System (ADS)

Burroughs, Richard H.; Clark, Tim W.

1995-09-01

Ecosystem management links human activities with the functioning of natural environments over large spatial and temporal scales. Our examination of Greater Yellowstone and Georges Bank shows similarities exist between human uses, administrative characteristics, and some biophysical features. Each region faces growing pressures to replace traditional extractive uses with more sustainable extractive or noncommodity uses coupled with concern about endangered species. Ecosystem management as a set of practical guidelines for making decisions under evolving expectations is far from complete, and it embodies new demands on individuals and institutions. In each system these challenges are considered relative to: the public's symbolic understanding of the management challenge, ecosystem management ambiguities, information availability, information use, administrative setting, and learning capabilities of governance organizations Progress in making ecosystem management operational may occur as refinements in content and approach make it an increasingly attractive option for resource users, the public, and government officials.

George Herbert Mead's Contribution to the Philosophy of American Education.

ERIC Educational Resources Information Center

Renger, Paul, III

1980-01-01

George Herbert Mead's general philsophy showed that he regarded the development of distinctively human behavior as essentially the result of an individual's meaningful participation in the social process of the community to which he belongs. Mead believed that education was a social process involving the meaningful interaction and communication…

Investing in Independence: Transition Recommendations for President George W. Bush.

ERIC Educational Resources Information Center

National Council on Disability, Washington, DC.

This paper presents rationale, strategies, and recommendations that the National Council on Disability believes are essential to how President George W. Bush and the new Administration can fulfill America's promise to its 54 million citizens with disabilities. President Bush is urged to install a disability friendly Administration, give disability…

Hurricane Georges: Headwater Flooding, Storm Surge, Beach Erosion, and Habitat Destruction on the Central Gulf Coast

DTIC Science & Technology

1998-10-01

SUBJECT TERMS Hurricane Georges (1998), flooding, Chandeleur Islands storm surge, beach erosion 15. NUMBER OF PAGES 16. PRICE CODE 17. SECURITY...near Pascagoula, MS, which is within about 1.5 feet of similar marks caused by Hurricane Camilleinl969(fig.4). CHANDELEUR ISLANDS The Chandeleur ...Hurricane Georges. Numerous cuts were made in the main Chandeleur island where many areas of vegetated landmasses were swept away, resulting

George Herbert Mead and the Allen controversy at the University of Wisconsin.

PubMed

Cook, Gary A

2007-01-01

This essay uses previously unpublished correspondence of George Herbert Mead to tell the story of his involvement in the aftermath of a political dispute that took place at the University of Wisconsin during the years 1914-1915. It seeks thereby to clarify the historical significance of an article he published on this controversy in late 1915. Taken together with relevant information about the educational activities of William H. Allen of the New York Bureau of Municipal Research, Mead's correspondence and article throw helpful light upon his understanding of how an educational survey of a university should proceed; they also show how he went about the task of evaluating a failed attempt at such a survey. (c) 2007 Wiley Periodicals, Inc.

EPA and partners celebrate redevelopment at Charles George Landfill Superfund Site

EPA Pesticide Factsheets

The Charles George Reclamation Trust Landfill Superfund site, a former landfill, is now home to a new solar facility. The USEPA oversaw the cleanup of the 70-acre Superfund site, preventing any exposure to contaminants and reducing leachate generation.

Increasing the Thermostable Sugar-1-Phosphate Nucleotidylyltransferase Activities of the Archaeal ST0452 Protein through Site Saturation Mutagenesis of the 97th Amino Acid Position.

PubMed

Honda, Yuki; Zang, Qian; Shimizu, Yasuhiro; Dadashipour, Mohammad; Zhang, Zilian; Kawarabayasi, Yutaka

2017-02-01

The ST0452 protein is a bifunctional protein exhibiting sugar-1-phosphate nucleotidylyltransferase (sugar-1-P NTase) and amino-sugar-1-phosphate acetyltransferase activities and was isolated from the thermophilic archaeon Sulfolobus tokodaii Based on the previous observation that five single mutations increased ST0452 sugar-1-P NTase activity, nine double-mutant ST0452 proteins were generated with the intent of obtaining enzymes exhibiting a further increase in catalysis, but all showed less than 15% of the wild-type N-acetyl-d-glucosamine-1-phosphate uridyltransferase (GlcNAc-1-P UTase) activity. The Y97A mutant exhibited the highest activity of the single-mutant proteins, and thus site saturation mutagenesis of the 97th position (Tyr) was conducted. Six mutants showed both increased GlcNAc-1-P UTase and glucose-1-phosphate uridyltransferase activities, eight mutants showed only enhanced GlcNAc-1-P UTase activity, and six exhibited higher GlcNAc-1-P UTase activity than that of the Y97A mutant. Kinetic analyses of three typical mutants indicated that the increase in sugar-1-P NTase activity was mainly due to an increase in the apparent k cat value. We hypothesized that changing the 97th position (Tyr) to a smaller amino acid with similar electronic properties would increase activity, and thus the Tyr at the corresponding 103rd position of the Escherichia coli GlmU (EcGlmU) enzyme was replaced with the same residues. The Y103N mutant EcGlmU showed increased GlcNAc-1-P UTase activity, revealing that the Tyr at the 97th position of the ST0452 protein (103rd position in EcGlmU) plays an important role in catalysis. The present results provide useful information regarding how to improve the activity of natural enzymes and how to generate powerful enzymes for the industrial production of sugar nucleotides. It is typically difficult to increase enzymatic activity by introducing substitutions into a natural enzyme. However, it was previously found that the ST0452 protein

Social Movements Against Racist Police Brutality and Department of Justice Intervention in Prince George's County, Maryland.

PubMed

Hutto, Jonathan W; Green, Rodney D

2016-04-01

Racist police brutality has been systemic in Prince George's County, Maryland. The victims include African Americans, the mentally challenged, and immigrant populations, creating a complex and uneven public health impact. Three threads characterize the social movements and intervention since 1970. First, a significant demographic shift occurred as African Americans became the majority population in the late 1980s when the first Black county executive was elected in 1994. Despite the change in political leadership, police brutality remained rampant. Lower-income households located close to the District of Columbia and "inside the beltway" experienced the most police brutality. In 2001, The Washington Post revealed that between 1990 and 2000, Prince George's police shot and killed more citizens per officer than any of the 50 largest city and county law enforcement agencies in the country, 84 % of whom were black. Of the 147 persons shot during the 1990s, 12 were mentally and/or emotionally disturbed; 6 of these shootings were fatal. Second, resistance to police brutality emerged in a variety of political formations throughout the period, especially in the late 1990s. Sustained community pressure prompted the Department of Justice (DOJ) to open a civil rights investigation of the police department in November 2000. To avoid a potential federal lawsuit, the county leadership negotiated a memorandum of agreement (MOA) with the DOJ to enact policy reforms, part of which called for supplementing the departmental mobile crisis team, comprised of mental health care professionals, to respond to all cases involving mentally challenged citizens. Third, the incomplete process of change subsequent to the ending of DOJ oversight suggests a continued challenge to social movements opposing police brutality. This study focuses on the effectiveness of the MOA along with the activism of the People's Coalition for Police Accountability (PCPA) in reforming a culture of police brutality

Somewhere through Time: A Discussion with George and Annemarie Roeper

ERIC Educational Resources Information Center

Schultz, Robert A.

2016-01-01

The discussion herein is guided by questions "asked" and responses "given" seemingly in one sitting. However, this is a façade. All responses are direct quotations from the published scholarly writings and unpublished archives of George and Annemarie Roeper. This is a conversation taking place somewhere in time, prompted by…

Humanizing the Humanities: Some Reflections on George Steiner's "Brutal Paradox."

ERIC Educational Resources Information Center

Karier, Clarence J.

1990-01-01

Considers how literary critic, George Steiner, explores the failure of Western Civilization to humanize humanity. Analyzes Steiner's ultimately elitist model of culture to shed light on implications of his brutal paradox in which Nazism's death camps are juxtaposed to high culture. Theorizes about the possibilities of a culture inclusive of all…

1. Historic American Buildings Survey, George W. Phillips, Photographer GENERAL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey, George W. Phillips, Photographer GENERAL VIEW, PESTLE IN RAISED POSITION (PHOTOGRAPHED IN ITS ORIGINAL LOCATION ON THE CINDY BAUMGARTNER PLACE, DEEP CREEK, N.C. BEFORE BEING REMOVED TO ITS PRESENT LOCATION). - Pounding Mill, Pioneer Museum, Route 441 (moved from Deep Creek), Cherokee, Swain County, NC

2. Historic American Buildings Survey, George W. Phillips, Photographer GENERAL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey, George W. Phillips, Photographer GENERAL VIEW, PESTLE IN LOWERED POSITION (PHOTOGRAPHED IN ITS ORIGINAL LOCATION ON THE CINDY BAUMGARTNER PLACE, DEEP CREEK, N.C. BEFORE BEING REMOVED TO ITS PRESENT LOCATION). - Pounding Mill, Pioneer Museum, Route 441 (moved from Deep Creek), Cherokee, Swain County, NC

Characterization of St and Y genome in StStYY Elymus species (Triticeae: Poaceae) using Sequential FISH and GISH

USDA-ARS?s Scientific Manuscript database

Tetraploid species possessing StY genome could be donors to hexaploid species having StYH, StYP, or StYW genome constitution in the genus Elymus, and a few of StY species have been intensely studied for inferring the origin of the Y genome. In this study, genome characterization of St and Y genome w...

Chemistry of St. John's Wort: Hypericin and Hyperforin

ERIC Educational Resources Information Center

Vollmer, John J.; Rosenson, Jon

2004-01-01

The appeal as natural antidepressant is the major selling point of St. John's Wort, which is referred to as "Prozac from the plant kingdom". Hypericin and hyperforin, two major constituents with significant biological activity of St. John's Wort and which are complex molecules with unusual features, are examined.

Growing Pains from Rapid Growth: A Historical Case Study of George Fox University from 1983 to 2003

ERIC Educational Resources Information Center

Railsback, Gary L.

2007-01-01

This article is a historical case study of George Fox University (GFU) in Newberg, Oregon. Using organizational lifecycle as a theoretical framework, George Fox University had a long and delayed childhood in that it remained a small and struggling institution for most of the 20th century, and then experienced rapid growth in the late 1980s. This…

Roegneria alashanica Keng: a species with the StStStYStY genome constitution

USDA-ARS?s Scientific Manuscript database

The genome constitution of tetraploid Roegneria alashanica Keng has been in question for a long time. Most scientific studies have suggested that R. alashanica had two versions of the St genome. Thus, the genome constitution of R. alashanica was assumed to be St1St2 similar to that of Pseudoroegne...

MEDIA

Science.gov Websites

engagement taking place with the Tajikistan Peacekeeping Battalion of the Mobile Forces and the 648th Exercise Eager Lion 2018. (U.S. Army photo by Sgt. 1st Class Patrick J. DeGeorge, 139th Mobile Public . 1st Class Patrick J. DeGeorge, 139th Mobile Public Affairs Detachment) Hi-Res | Photo Gallery MacDill

Eruptions of Mount St. Helens : Past, present, and future

USGS Publications Warehouse

Tilling, Robert I.; Topinka, Lyn J.; Swanson, Donald A.

1990-01-01

Mount St. Helens, located in southwestern Washington about 50 miles northeast of Portland, Oregon, is one of several lofty volcanic peaks that dominate the Cascade Range of the Pacific Northwest; the range extends from Mount Garibaldi in British Columbia, Canada, to Lassen Peak in northern California. Geologists call Mount St. Helens a composite volcano (or stratovolcano), a term for steepsided, often symmetrical cones constructed of alternating layers of lava flows, ash, and other volcanic debris. Composite volcanoes tend to erupt explosively and pose considerable danger to nearby life and property. In contrast, the gently sloping shield volcanoes, such as those in Hawaii, typically erupt nonexplosively, producing fluid lavas that can flow great distances from the active vents. Although Hawaiian-type eruptions may destroy property, they rarely cause death or injury. Before 1980, snow-capped, gracefully symmetrical Mount St. Helens was known as the "Fujiyama of America." Mount St. Helens, other active Cascade volcanoes, and those of Alaska form the North American segment of the circum-Pacific "Ring of Fire," a notorious zone that produces frequent, often destructive, earthquake and volcanic activity.

Failure of George Mason University's Persian Gulf Campus Sparks Concern

ERIC Educational Resources Information Center

Mills, Andrew

2009-01-01

Late last month, when George Mason University's campus in the Persian Gulf emirate of Ras al Khaymah became the first American educational venture in the region to collapse, its administrators immediately blamed the international economic meltdown. In a region whose higher-education scene is quickly gaining a reputation for being as hazardous as…

Compressional velocities from multichannel refraction arrivals on Georges Bank: northwest Atlantic Ocean

USGS Publications Warehouse

McGinnis, L. D.; Otis, R. M.

1979-01-01

Velocities were obtained from unreversed, refracted arrivals on analog records from a 48‐channel, 3.6-km hydrophone cable (3.89 km from the airgun array to the last hydrophone array). Approximately 200 records were analyzed along 1500 km of ship track on Georges Bank, northwest Atlantic Ocean, to obtain regional sediment velocity distribution to a depth of 1.4 km below sea level. This technique provides nearly continuous coverage of refraction velocities and vertical velocity gradients. Because of the length of the hydrophone cable and the vertical velocity gradients, the technique is applicable only to the Continental Shelf and the shallower parts of the Continental Slope in water depths less than 300 m. Sediment diagenesis, the influence of overburden pressure on compaction, lithology, density, and porosity are inferred from these data. Velocities of the sediment near the water‐sediment interface range from less than 1500 m/sec on the north edge of Georges Bank to 1830 m/sec for glacial deposits in the northcentral part of the bank. Velocity gradients in the upper 400 m range from 1.0km/sec/km(sec−1) on the south edge of the bank to 1.7sec−1 on the north. Minimum gradients of 0.8sec−1 were observed south of Nantucket Island. Velocities and velocity gradients are explained in relation to physical properties of the Cretaceous, Tertiary, and Pleistocene sediments. Isovelocity contours at 100-m/sec intervals are nearly horizontal in the upper 400 m. Isovelocity contours at greater depths show a greater difference from a mean depth because of the greater structural and lithological variation. Bottom densities inferred from the velocities range from 1.7 to 1.9g/cm3 and porosities range from 48 to 62 percent. The most significant factor controlling velocity distribution on Georges Bank is overburden pressure and resulting compaction. From the velocity data we conclude that Georges Bank has been partially overridden by a continental ice sheet.

Britain's first medical marriage: Frances Morgan (1843-1927), George Hoggan (1837-1891) and the mysterious "Elsie".

PubMed

McIntyre, Neil

2004-05-01

Britain's first medical marriage was between George Hoggan and Frances Morgan, in 1874. George was a naval engineer before he studied medicine; he showed great promise in research before his death, aged 54, after a long illness. Frances was arguably the most gifted of the early medical women. She was the first British woman to obtain an MD in Europe and the first to do high-quality medical research. Her clinical practice was curtailed by George's illness and death but she continued to campaign on social issues--including women's education, health education and civil rights. Her life was all the more remarkable because new evidence suggests that, at the age of 17, before she started her medical studies, she gave birth to an illegitimate child. Had this been known it would, in Victorian times, have dashed her hopes of a career in medicine.

Interactions between surface waters in King George Island, Antarctica - a stable isotope perspective

NASA Astrophysics Data System (ADS)

Perşoiu, Aurel; Bădăluşă, Carmen

2017-04-01

In this paper we present a first study of the isotopic composition of surface waters in the southern peninsulas (Barton, Fildes, Weaver and Potter) of King George Island, Antarctica. We have collected > 200 samples of snow and snowmelt, water (lake, river and spring), ice (glacier ice and permafrost) from the four peninsulas in February 2016 and analyzed them for their oxygen and hydrogen stable isotopic composition. Samples from lake water (50+) indicate a clear west-east depletion trend, suggesting a rain-out process as air masses are moving westward (and are progressively depleted in heavy isotopes) from their origin in the Drake Passage. In both Fildes and Barton Peninsulas, permafrost samples have the heaviest isotopic composition, most probably due to preferential incorporation of heavy isotopes in the ice during freezing (and no fractionation during melting). As permafrost melts, the resulting water mixes with isotopically lighter infiltrated snowmelt, and thus the groundwater has a lower isotopic composition. Further, lake and river (the later fed by lakes) water has the lightest isotopic composition, being derived mostly from the melting of light snow and glacier ice. It seems feasible to separate isotopically water in lakes/rivers (largely fed by melting multi-year glaciers and snow) and water from melting of snow/ground ice This preliminary study suggests that it is possible to separate various water sources in the southern peninsulas of King George Island, and this separation could be used to study permafrost degradation, as well as feeding and migration patterns in the bird fauna, with implications for protection purposes. Acknowledgments. The National Institute of Research and Development for Biological Sciences (Bucharest, Romania) and the Korean polar institute financially supported fieldwork in King George Island. We thank the personal at King Sejong (South Korea), Belingshaussen (Russia) and Carlini (Argentina) stations in King George Island for

George Eliot's interrogation of physiological future knowledge.

PubMed

Claggett, Shalyn

2011-01-01

This essay tracks George Eliot's sustained interest in the epistemological problems surrounding the Victorian tendency to envision the future through the body's materiality. It argues that her nuanced criticism of phrenology in "The Lifted Veil" (1859) and "A Minor Prophet" (1865) addresses the delimiting psychological and social effects that attend an applied theory of physiological determinism. Returning to this problem in Daniel Deronda (1876), Eliot offers Mordecai's plan to posit Deronda's body as a living emblem as a radical alternative to racial iconography and typological meaning—a move that allowed her to reconcile the body's legibility with a future beyond socially inscribed possibilities.

George Mandler (1924-2016).

PubMed

Craik, Fergus

2017-10-01

Presents an obituary for George Mandler, who died in London on May 6, 2016 at the age of 91. Mandler was one of the pioneers of the cognitive revolution in psychology. He was instrumental in moving the study of human learning from notions based largely on associations to a view of memory as an organized, nested hierarchical structure. Mandler was also a major proponent of the dual-process theory of recognition memory, in which general feelings of familiarity are distinguished from the context-rich experience of recollection. He brought the study of emotion into prominence, suggesting how emotion and cognition are related. Finally, he repatriated the concept of consciousness from its intellectual exile under behaviorism, stating boldly in 1975 that the construct was respectable, useful, and probably necessary. Mandler edited the Psychological Review from 1970 to 1976, chaired the Governing Board of the Psychonomic Society, and was president of APA Divisions 1 (General Psychology) and 3 (Experimental Psychology and Cognitive Science). (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Genetic Drivers of Kidney Defects in the DiGeorge Syndrome.

PubMed

Lopez-Rivera, Esther; Liu, Yangfan P; Verbitsky, Miguel; Anderson, Blair R; Capone, Valentina P; Otto, Edgar A; Yan, Zhonghai; Mitrotti, Adele; Martino, Jeremiah; Steers, Nicholas J; Fasel, David A; Vukojevic, Katarina; Deng, Rong; Racedo, Silvia E; Liu, Qingxue; Werth, Max; Westland, Rik; Vivante, Asaf; Makar, Gabriel S; Bodria, Monica; Sampson, Matthew G; Gillies, Christopher E; Vega-Warner, Virginia; Maiorana, Mariarosa; Petrey, Donald S; Honig, Barry; Lozanovski, Vladimir J; Salomon, Rémi; Heidet, Laurence; Carpentier, Wassila; Gaillard, Dominique; Carrea, Alba; Gesualdo, Loreto; Cusi, Daniele; Izzi, Claudia; Scolari, Francesco; van Wijk, Joanna A E; Arapovic, Adela; Saraga-Babic, Mirna; Saraga, Marijan; Kunac, Nenad; Samii, Ali; McDonald-McGinn, Donna M; Crowley, Terrence B; Zackai, Elaine H; Drozdz, Dorota; Miklaszewska, Monika; Tkaczyk, Marcin; Sikora, Przemyslaw; Szczepanska, Maria; Mizerska-Wasiak, Malgorzata; Krzemien, Grazyna; Szmigielska, Agnieszka; Zaniew, Marcin; Darlow, John M; Puri, Prem; Barton, David; Casolari, Emilio; Furth, Susan L; Warady, Bradley A; Gucev, Zoran; Hakonarson, Hakon; Flogelova, Hana; Tasic, Velibor; Latos-Bielenska, Anna; Materna-Kiryluk, Anna; Allegri, Landino; Wong, Craig S; Drummond, Iain A; D'Agati, Vivette; Imamoto, Akira; Barasch, Jonathan M; Hildebrandt, Friedhelm; Kiryluk, Krzysztof; Lifton, Richard P; Morrow, Bernice E; Jeanpierre, Cecile; Papaioannou, Virginia E; Ghiggeri, Gian Marco; Gharavi, Ali G; Katsanis, Nicholas; Sanna-Cherchi, Simone

2017-02-23

The DiGeorge syndrome, the most common of the microdeletion syndromes, affects multiple organs, including the heart, the nervous system, and the kidney. It is caused by deletions on chromosome 22q11.2; the genetic driver of the kidney defects is unknown. We conducted a genomewide search for structural variants in two cohorts: 2080 patients with congenital kidney and urinary tract anomalies and 22,094 controls. We performed exome and targeted resequencing in samples obtained from 586 additional patients with congenital kidney anomalies. We also carried out functional studies using zebrafish and mice. We identified heterozygous deletions of 22q11.2 in 1.1% of the patients with congenital kidney anomalies and in 0.01% of population controls (odds ratio, 81.5; P=4.5×10 -14 ). We localized the main drivers of renal disease in the DiGeorge syndrome to a 370-kb region containing nine genes. In zebrafish embryos, an induced loss of function in snap29, aifm3, and crkl resulted in renal defects; the loss of crkl alone was sufficient to induce defects. Five of 586 patients with congenital urinary anomalies had newly identified, heterozygous protein-altering variants, including a premature termination codon, in CRKL. The inactivation of Crkl in the mouse model induced developmental defects similar to those observed in patients with congenital urinary anomalies. We identified a recurrent 370-kb deletion at the 22q11.2 locus as a driver of kidney defects in the DiGeorge syndrome and in sporadic congenital kidney and urinary tract anomalies. Of the nine genes at this locus, SNAP29, AIFM3, and CRKL appear to be critical to the phenotype, with haploinsufficiency of CRKL emerging as the main genetic driver. (Funded by the National Institutes of Health and others.).

Genetic Drivers of Kidney Defects in the DiGeorge Syndrome

PubMed Central

Lopez-Rivera, E.; Liu, Y.P.; Verbitsky, M.; Anderson, B.R.; Capone, V.P.; Otto, E.A.; Yan, Z.; Mitrotti, A.; Martino, J.; Steers, N.J.; Fasel, D.A.; Vukojevic, K.; Deng, R.; Racedo, S.E.; Liu, Q.; Werth, M.; Westland, R.; Vivante, A.; Makar, G.S.; Bodria, M.; Sampson, M.G.; Gillies, C.E.; Vega-Warner, V.; Maiorana, M.; Petrey, D.S.; Honig, B.; Lozanovski, V.J.; Salomon, R.; Heidet, L.; Carpentier, W.; Gaillard, D.; Carrea, A.; Gesualdo, L.; Cusi, D.; Izzi, C.; Scolari, F.; van Wijk, J.A.E.; Arapovic, A.; Saraga-Babic, M.; Saraga, M.; Kunac, N.; Samii, A.; McDonald-McGinn, D.M.; Crowley, T.B.; Zackai, E.H.; Drozdz, D.; Miklaszewska, M.; Tkaczyk, M.; Sikora, P.; Szczepanska, M.; Mizerska-Wasiak, M.; Krzemien, G.; Szmigielska, A.; Zaniew, M.; Darlow, J.M.; Puri, P.; Barton, D.; Casolari, E.; Furth, S.L.; Warady, B.A.; Gucev, Z.; Hakonarson, H.; Flogelova, H.; Tasic, V.; Latos-Bielenska, A.; Materna-Kiryluk, A.; Allegri, L.; Wong, C.S.; Drummond, I.A.; D’Agati, V.; Imamoto, A.; Barasch, J.M.; Hildebrandt, F.; Kiryluk, K.; Lifton, R.P.; Morrow, B.E.; Jeanpierre, C.; Papaioannou, V.E.; Ghiggeri, G.M.; Gharavi, A.G.; Katsanis, N.; Sanna-Cherchi, S.

2017-01-01

BACKGROUND The DiGeorge syndrome, the most common of the microdeletion syndromes, affects multiple organs, including the heart, the nervous system, and the kidney. It is caused by deletions on chromosome 22q11.2; the genetic driver of the kidney defects is unknown. METHODS We conducted a genomewide search for structural variants in two cohorts: 2080 patients with congenital kidney and urinary tract anomalies and 22,094 controls. We performed exome and targeted resequencing in samples obtained from 586 additional patients with congenital kidney anomalies. We also carried out functional studies using zebrafish and mice. RESULTS We identified heterozygous deletions of 22q11.2 in 1.1% of the patients with congenital kidney anomalies and in 0.01% of population controls (odds ratio, 81.5; P=4.5×10−14). We localized the main drivers of renal disease in the DiGeorge syndrome to a 370-kb region containing nine genes. In zebrafish embryos, an induced loss of function in snap29, aifm3, and crkl resulted in renal defects; the loss of crkl alone was sufficient to induce defects. Five of 586 patients with congenital urinary anomalies had newly identified, heterozygous protein-altering variants, including a premature termination codon, in CRKL. The inactivation of Crkl in the mouse model induced developmental defects similar to those observed in patients with congenital urinary anomalies. CONCLUSIONS We identified a recurrent 370-kb deletion at the 22q11.2 locus as a driver of kidney defects in the DiGeorge syndrome and in sporadic congenital kidney and urinary tract anomalies. Of the nine genes at this locus, SNAP29, AIFM3, and CRKL appear to be critical to the phenotype, with haploinsufficiency of CRKL emerging as the main genetic driver. (Funded by the National Institutes of Health and others.) PMID:28121514

Vehicles to Belief: Aristotle's Enthymeme and George Campbell's Vivacity Compared.

ERIC Educational Resources Information Center

Roob, Andy

The central concepts from two rhetorical systems (the enthymeme in Aristotle's rhetoric and vivacity in George Campbell's) may be understood as the connection between speech act and ascension to belief. A review of the literature indicates a gap in the scholarly works seeking to compare and contrast the periods developed by D. Ehninger's systems…

Resuscitation great. George W. Crile: a visionary mind in resuscitation.

PubMed

Soto-Ruiz, Karina M; Varon, Joseph

2009-01-01

George Washington Crile was a successful surgeon who lived at the end of the 19th century. He was born on 11 November 1864 on a farm near Chili, Ohio. He became interested in the study of shock after a close friend died from hemorrhage. Crile dedicated his research years to the study of shock, cardiac arrest, and the use of adrenaline. His research on shock and cardiac arrest led to treatment guidelines that are still used today. He also participated in the Spanish-American War and in World War I as a Navy Surgeon and saved the lives of many soldiers with his principles of blood transfusion and sanitation. He is also known in the surgical world as the grandfather of radical neck dissection and received the Gold Lannelongue Medal and prize. Having written over 400 papers and 24 books, George W. Crile died from complications of bacterial endocarditis on 7th January 1943. Although they were published a long time ago, his contributions to medicine remain fundamental to clinical practice in today's operating rooms and critical care units.

Distribution of bacterioplankton with active metabolism in waters of the St. Anna Trough, Kara Sea, in autumn 2011

NASA Astrophysics Data System (ADS)

Mosharova, I. V.; Mosharov, S. A.; Ilinskiy, V. V.

2017-01-01

The distribution of bacterioplankton with active electron transport chains, as well as bacteria with intact cell membranes, was investigated for the first time in the region of St. Anna Trough in the Kara Sea. The average number of bacteria with active electron transport chains in the waters of the St. Anna Trough was 15.55 × 103 cells mL-1 (the limits of variation were 1.06-92.17 × 103 cells mL-1). The average number of bacteria with intact membranes was 33.46 × 103 cells mL-1 (the limits of variation were 6.78 to 103.18 × 103 cells mL-1). Almost all bacterioplankton microorganisms in the studied area were potentially viable, and the average share of bacteria with intact membranes was 92.1% of the total number of bacterioplankton (TNB) (the limits of variation were 76.2 to 98.4%). The share of bacteria with active metabolisms was 38.2% of the TNB (the limits of variation were 5.6-93.4%). The shares of the bacteria with active metabolisms were maximum in areas with the most stable environmental conditions (on the shelf and in deep water), whereas on the slope, where the gradients of water temperature and salinity were maximum, these values were lower.

Mt. St. Helens Memories.

ERIC Educational Resources Information Center

Sharp, Len

1992-01-01

Provides a personal account of one science teacher's participation in a teacher workshop in which teachers learned about volcanic development, types of eruption, geomorphology, plate tectonics, volcano monitoring, and hazards created by volcanoes by examining Mt. St. Helens. Provides a graphic identifying volcanoes active since 1975. (MDH)

Metabolism of hyperforin, the active constituent of St. John's wort, in human liver microsomes.

PubMed

Hokkanen, Juho; Tolonen, Ari; Mattila, Sampo; Turpeinen, Miia

2011-02-14

The metabolism of hyperforin, one of the pharmacologically most active components of St. John's wort (Hypericum perforatum), was characterized in vitro using human liver microsomes and recombinant heterologously expressed P450 enzymes. A total of 57 hyperforin metabolites were detected. Of those, six were identified as monohydroxylations (M1-M6), while the others were formed via two or more hydroxylation reactions, via dehydrogenation, or by combinations of these reactions. A combined approach of cDNA-expressed recombinant CYPs, CYP-selective chemical inhibitors and correlation with CYP-specific marker activities indicated a central role of the CYP2C and CYP3A families in the metabolism of hyperforin. In addition, hyperforin was found to inhibit CYP2D6 and CYP3A4 model activities quite potently. Copyright © 2010 Elsevier B.V. All rights reserved.

Temporal variation of mass-wasting activity in Mount St. Helens crater, Washington, U. S. A. indicated by seismic activity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mills, H.H.

1991-11-01

In the crater of Mount St. Helens, formed during the eruption of 18 May 1980, thousands of rockfalls may occur in a single day, and some rock and dirty-snow avalanches have traveled more than 1 km from their source. Because most seismic activity in the crater is produced by mass wasting, the former can be used to monitor the latter. The number and amplitude of seismic events per unit time provide a generalized measure of mass-wasting activity. In this study 1-min averages of seismic amplitudes were used as an index of rockfall activity during summer and early fall. Plots ofmore » this index show the diurnal cycle of rockfall activity and establish that the peak in activity occurs in mid to late afternoon. A correlation coefficient of 0.61 was found between daily maximum temperature and average seismic amplitude, although this value increases to 0.72 if a composite temperature variable that includes the maximum temperature of 1 to 3 preceding days as well as the present day is used. Correlation with precipitation is much weaker.« less

Immunotherapy trials for type 1 diabetes: the contribution of George Eisenbarth.

PubMed

Skyler, Jay S; Pugliese, Alberto

2013-06-01

Type 1 diabetes (T1D) results from the autoimmune destruction of pancreatic β-cells, and as such it should respond to immunotherapy. George Eisenbarth gave many significant contributions to this field. He has been involved at some level in most immunotherapy trials during the past three decades. He was among the pioneers who attempted immunotherapy approaches in patients with recent-onset T1D. In the early 1980s he began studying relatives of those with the disease, leading to the concept that T1D was a chronic autoimmune disease, in which islet autoimmune responses would silently destroy β-cells and cause progressive impairment of insulin secretion, years to months before a diagnosis was made. Consequently, he was one of the first to attempt immune intervention in people at high risk of T1D. Throughout his career he developed autoantibody assays and predictive models (which included metabolic testing and later genetics) to identify individuals at risk of T1D. He provided seminal intellectual contributions and critical tools for prevention trials. His focus on insulin as a critical autoantigen led to multiple prevention trials, including the Diabetes Prevention Trial-Type 1 (DPT-1), which studied both parenteral and oral insulin. In the DPT-1 Oral Insulin Trial, a cohort with higher levels of insulin autoantibodies was identified that appeared to have delayed disease progression. Type 1 Diabetes TrialNet is conducting a new trial to verify or refute this observation. Moreover, George identified and tested in the mouse small molecules that block or modulate presentation of a key insulin peptide and in turn prevent the activation of insulin-specific T-lymphocytes. Thus, we believe his greatest contribution is yet to come, as in the near future we should see this most recent work translate into clinical trials.

UMCS feasibility study for Fort George G. Meade. Volume 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-12-01

Fort George G. Meade selected eighty-three (83) buildings, from the approximately 1,500 buildings on the base to be included in the UMCS Feasibility Study. The purpose of the study is to evaluate the feasibility of replacing the existing analog based Energy Monitoring and Control System (EMCS) with a new distributed process Monitoring and Control System (UMCS).

E-st@r-I experience: Valuable knowledge for improving the e-st@r-II design

NASA Astrophysics Data System (ADS)

Corpino, S.; Obiols-Rabasa, G.; Mozzillo, R.; Nichele, F.

2016-04-01

Many universities all over the world have now established hands-on education programs based on CubeSats. These small and cheap platforms are becoming more and more attractive also for other-than-educational missions, such as technology demonstration, science applications, and Earth observation. This new paradigm requires the development of adequate technology to increase CubeSat performance and mission reliability, because educationally-driven missions have often failed. In 2013 the ESA Education Office launched the Fly Your Satellite! Programme which aims at increasing CubeSat mission reliability through several actions: to improve design implementation, to define best practices for conducting the verification process, and to make the CubeSat community aware of the importance of verification. Within this framework, the CubeSat team at Politecnico di Torino developed the e-st@r-II CubeSat as follow-on of the e-st@r-I satellite, launched in 2012 on the VEGA Maiden Flight. E-st@r-I and e-st@r-II are both 1U satellites with educational and technology demonstration objectives: to give hands-on experience to university students and to test an active attitude determination and control system based on inertial and magnetic measurements with magnetic actuation. This paper describes the know-how gained thanks to the e-st@r-I mission, and how this heritage has been translated into the improvement of the new CubeSat in several areas and lifecycle phases. The CubeSat design has been reviewed to reduce the complexity of the assembly procedure and to deal with possible failures of the on-board computer, for example re-coding the software in the communications subsystem. New procedures have been designed and assessed for the verification campaign accordingly to ECSS rules and with the support of ESA specialists. Different operative modes have been implemented to handle some anomalies observed during the operations of the first satellite. A new version of the on-board software is

Role of Imaging and Cytogenetics in Evaluation of DiGeorge Syndrome - A Rare Entity in Clinical Practice.

PubMed

Ramachandran, Rajoo; Babu, Sellappan Rajamanickam; Ilanchezhian, Subramanian; Radhakrishnan, Prabhu Radhan

2015-01-01

DiGeorge syndrome is a congenital genetic disorder that affects the endocrine system, mainly the thymus and parathyroid glands. The syndrome produces different symptoms, which vary in severity and character between patients. It manifests with craniofacial dysmorphism and defects in the heart, parathyroid, and thymus. Patients can present with a palatal deformity and nasal speech. This rare entity is caused mainly due to deletion of chromosome 22q11.2. Radiographic evaluation of DiGeorge syndrome is necessary to define aberrant anatomy, evaluate central nervous system, craniofacial abnormalities, musculoskeletal system, and cardiothoracic contents. It also helps in planning surgical procedures and surgical reconstructions. We report a case of DiGeorge syndrome in a 4-month-old neonate and discuss the clinical, imaging, and cytogenetic findings that helped in the diagnosis of this rare entity.

Remembering Dr. George J. Apel, Jr: A Posthumous Tribute to an Innovative, Obscure Pioneer in Christian Higher Education

ERIC Educational Resources Information Center

Lumadue, Richard T.

2007-01-01

This paper is a belated tribute to George J. Apel, Jr., an innovative and obscure Christian higher educator. Peruse the name and subject indices of any and all books about Christian higher education, and nowhere will there appear even a reference to George J. Apel, Jr. Although Apel never finished high school or college, he was awarded an honorary…

9. AERIAL VIEW LOOKING NORTH AT THE GEORGE C. MARSHALL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. AERIAL VIEW LOOKING NORTH AT THE GEORGE C. MARSHALL SPACE FLIGHT CENTER. DODD ROAD RUNS DOWN THE CENTER OF THE PHOTO. THE EAST TEST AREA IS TOWARDS THE BOTTOM OF THE PHOTO, FABRICATION, ENGINEERING AND ADMINISTRATION NEAR THE TOP OF THE PHOTO. 1961, MSFC PHOTO LAB. - Marshall Space Flight Center, East Test Area, Dodd Road, Huntsville, Madison County, AL

Catalog of Completed Studies, US Army Health Care Studies and Clinical Investigation Activity.

DTIC Science & Technology

1984-12-10

EDUCATION: B.S., 1967, University of Texas at Austin (Chemistry) Ph.D., 1972, University of Southern California (Molecular Biology ) MEMBERSHIP...WALTER A. BRUSCH RANK: COL, Dental Corps Chief: Dental Studies EDUCATION: B.S., 1957, Xavier University ( Biology ) D.D.S., 1961, St. Louis University M.S.D... Biology , New York University D.M.D., 1971, University of Pennsylvania M.A., 1979, Education, George Washington University M.S.P.H., 1982, University of

Structure of the dimerization domain of DiGeorge Critical Region 8

PubMed Central

Senturia, Rachel; Faller, Michael; Yin, Sheng; Loo, Joseph A; Cascio, Duilio; Sawaya, Michael R; Hwang, Daniel; Clubb, Robert T; Guo, Feng

2010-01-01

Maturation of microRNAs (miRNAs, ∼22nt) from long primary transcripts [primary miRNAs (pri-miRNAs)] is regulated during development and is altered in diseases such as cancer. The first processing step is a cleavage mediated by the Microprocessor complex containing the Drosha nuclease and the RNA-binding protein DiGeorge critical region 8 (DGCR8). We previously reported that dimeric DGCR8 binds heme and that the heme-bound DGCR8 is more active than the heme-free form. Here, we identified a conserved dimerization domain in DGCR8. Our crystal structure of this domain (residues 298–352) at 1.7 Å resolution demonstrates a previously unknown use of a WW motif as a platform for extensive dimerization interactions. The dimerization domain of DGCR8 is embedded in an independently folded heme-binding domain and directly contributes to association with heme. Heme-binding-deficient DGCR8 mutants have reduced pri-miRNA processing activity in vitro. Our study provides structural and biochemical bases for understanding how dimerization and heme binding of DGCR8 may contribute to regulation of miRNA biogenesis. PMID:20506313

The Geological Environment West of St. Croix

DTIC Science & Technology

1977-03-01

plateau’s surface. The plateau was probably similar in depth and structural disposition, with respect to the island of St. Croix and the island slope, during...St. Croix at 800-1,200 m depth . The plateau is dissected by three submarine canyons. Rock outcrops are largely confined to the walls of the canyons...absence of stratigraphic control. A NE/SW syncline underlies the Plateau and controls the location of Frederick- sted Canyon. Structural activity

Department of Neurology, King George's Medical University, Lucknow: The journey continues.

PubMed

Sharma, Praveen Kumar; Garg, Ravindra Kumar; Malhotra, Hardeep Singh; Shukla, Rakesh; Verma, Rajesh

2015-01-01

King George Medical University is one of the oldest and most prestigious medical universities of India. The Department of Neurology has trained many illustrious neurologists who are offering yeoman's service to the nation. This brief review traces the history and milestones of the department and its current areas of focus.

A single cell level measurement of StAR expression and activity in adrenal cells.

PubMed

Lee, Jinwoo; Yamazaki, Takeshi; Dong, Hui; Jefcoate, Colin

2017-02-05

The Steroidogenic acute regulatory protein (StAR) directs mitochondrial cholesterol uptake through a C-terminal cholesterol binding domain (CBD) and a 62 amino acid N-terminal regulatory domain (NTD) that contains an import sequence and conserved sites for inner membrane metalloproteases. Deletion of the NTD prevents mitochondrial import while maintaining steroidogenesis but with compromised cholesterol homeostasis. The rapid StAR-mediated cholesterol transfer in adrenal cells depends on concerted mRNA translation, p37 StAR phosphorylation and controlled NTD cleavage. The NTD controls this process with two cAMP-inducible modulators of, respectively, transcription and translation SIK1 and TIS11b/Znf36l1. High-resolution fluorescence in situ hybridization (HR-FISH) of StAR RNA resolves slow RNA splicing at the gene loci in cAMP-induced Y-1 cells and transfer of individual 3.5 kB mRNA molecules to mitochondria. StAR transcription depends on the CREB coactivator CRTC2 and PKA inhibition of the highly inducible suppressor kinase SIK1 and a basal counterpart SIK2. PKA-inducible TIS11b/Znf36l1 binds specifically to highly conserved elements in exon 7 thereby suppressing formation of mRNA and subsequent translation. Co-expression of SIK1, Znf36l1 with 3.5 kB StAR mRNA may limit responses to pulsatile signaling by ACTH while regulating the transition to more prolonged stress. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

A single cell level measurement of StAR expression and activity in adrenal cells

PubMed Central

Lee, Jinwoo; Yamazaki, Takeshi; Dong, Hui; Jefcoate, Colin

2018-01-01

The Steroidogenic acute regulatory protein (StAR) directs mitochondrial cholesterol uptake through a C-terminal cholesterol binding domain (CBD) and a 62 amino acid N-terminal regulatory domain (NTD) that contains an import sequence and conserved sites for inner membrane metalloproteases. Deletion of the NTD prevents mitochondrial import while maintaining steroidogenesis but with compromised cholesterol homeostasis. The rapid StAR-mediated cholesterol transfer in adrenal cells depends on concerted mRNA translation, p37 StAR phosphorylation and controlled NTD cleavage. The NTD controls this process with two cAMP-inducible modulators of, respectively, transcription and translation SIK1 and TIS11b/Znf36l1. High-resolution fluorescence in situ hybridization (HR-FISH) of StAR RNA resolves slow RNA splicing at the gene loci in cAMP-induced Y-1 cells and transfer of individual 3.5 kb mRNA molecules to mitochondria. StAR transcription depends on the CREB coactivator CRTC2 and PKA inhibition of the highly inducible suppressor kinase SIK1 and a basal counterpart SIK2. PKA-inducible TIS11b/Znf36l1 binds specifically to highly conserved elements in exon 7 thereby suppressing formation of mRNA and subsequent translation. Co-expression of SIK1, Znf36l1 with 3.5 kb StAR mRNA may limit responses to pulsatile signaling by ACTH while regulating the transition to more prolonged stress PMID:27521960

Road guide to volcanic deposits of Mount St. Helens and vicinity, Washington

USGS Publications Warehouse

Doukas, Michael P.

1990-01-01

Mount St. Helens, the most recently active and most intensively studied Cascades volcano, is in southwestern Washington. The volcano is a superb outdoor laboratory for studying volcanic processes, deposits of observed events, and deposits whose origins are inferred by classic geologic techniques, including analogy to recent deposits. During the past 4,500 years, Mount St. Helens has been more active and more explosive than any other volcano in the conterminous United States. Mount St. Helens became active in mid-March 1980, and eruptive activity began on March 27. Since the climactic eruption of May 18, 1980, the volcano has continued to be active at least until 1988. The 1890 activity of Mount St. Helens is summarized in U.S. Geological Survey Professional Papers 1249 and 1250. This road guide is a tour of Mount St. Helens volcano and vicinity, with emphasis on the effects and deposits of the 1980 eruption. The road log starts from the U.S. Geological Survey's David A. Johnston Cascades Volcano Observatory, Vancouver, Washington. The guide is organized around two primary routes. LEG I is on paved and gravel roads from Vancouver to areas east of Mount St. Helens, including Windy Ridge Overlook near Spirit Lake. This is possibly the most scenic route described in the guide, including a transect of the devastated zone of May 18, 1980, Spirit Lake, and numerous vistas of the volcano. LEG II leads to areas west of the volcano from Vancouver via U.S. Interstate Highway 5, then on a paved ... road along the Toutle River. Highlights include the spectacular effects of mudflows and a view of the huge debris-avalanche deposit that was formed on May 18, 1980.

StAR Enhances Transcription of Genes Encoding the Mitochondrial Proteases Involved in Its Own Degradation

PubMed Central

Bahat, Assaf; Perlberg, Shira; Melamed-Book, Naomi; Lauria, Ines; Langer, Thomas

2014-01-01

Steroidogenic acute regulatory protein (StAR) is essential for steroid hormone synthesis in the adrenal cortex and the gonads. StAR activity facilitates the supply of cholesterol substrate into the inner mitochondrial membranes where conversion of the sterol to a steroid is catalyzed. Mitochondrial import terminates the cholesterol mobilization activity of StAR and leads to mounting accumulation of StAR in the mitochondrial matrix. Our studies suggest that to prevent mitochondrial impairment, StAR proteolysis is executed by at least 2 mitochondrial proteases, ie, the matrix LON protease and the inner membrane complexes of the metalloproteases AFG3L2 and AFG3L2:SPG7/paraplegin. Gonadotropin administration to prepubertal rats stimulated ovarian follicular development associated with increased expression of the mitochondrial protein quality control system. In addition, enrichment of LON and AFG3L2 is evident in StAR-expressing ovarian cells examined by confocal microscopy. Furthermore, reporter studies of the protease promoters examined in the heterologous cell model suggest that StAR expression stimulates up to a 3.5-fold increase in the protease gene transcription. Such effects are StAR-specific, are independent of StAR activity, and failed to occur upon expression of StAR mutants that do not enter the matrix. Taken together, the results of this study suggest the presence of a novel regulatory loop, whereby acute accumulation of an apparent nuisance protein in the matrix provokes a mitochondria to nucleus signaling that, in turn, activates selected transcription of genes encoding the enrichment of mitochondrial proteases relevant for enhanced clearance of StAR. PMID:24422629

Rev. Dr. George W. Kerby: Evangelist for the Home and School.

ERIC Educational Resources Information Center

Owen, Michael

1993-01-01

George W. Kerby--minister, evangelist, and educational reformer--helped lead the Home and School movement in Canada during the 1920s and 1930s. He advocated child-centered relevant curriculum and cooperation between home and school. Kerby used ideas from both the progressive education and New Education movements but contributed to public…

From Myth to Reality: Humanities Study at Prince George's Community College.

ERIC Educational Resources Information Center

Engleberg, Isa N.

In 1989, Prince George's Community College (PGCC) received a grant from the National Endowment for the Humanities to support a 4-week summer seminar in Greek mythology for humanities faculty. The seminar, entitled "The Nature and Function of Greek Mythology," provided enough financial compensation to free the faculty from summer school teaching,…

Tuning in to High-Fidelity Interventions: A Conversation with George Sugai

ERIC Educational Resources Information Center

Teagarden, Jim; Zabel, Robert; Kaff, Marilyn

2016-01-01

George Sugai is the Carole J. Neag Endowed Chair in Behavior Disorders in the Neag School of Education at the University of Connecticut. He previously served on the faculty at the University of Oregon and the University of Kentucky. At Connecticut, Dr. Sugai and colleagues established the Center for Behavioral Educational and Research…

Color banding on Georges Bank as viewed by coastal zone color scanner

NASA Technical Reports Server (NTRS)

Yentsch, C. S.; Phinney, D. A.; Campbell, J. W.

1994-01-01

Observations of Georges Bank by coastal zone color scanner (CZCS) show bandlike patterns that appear to be related to the large sand dunes and ridges which dominate the bottom topography there. Ship measurements of temperature and chlorophyll on Georges Bank in July 1979 also reflect the influence of the underwater dune fields. The cause of the banding in the CZCS data is unknown but is speculated to be the creation of alternating zones of divergence and convergence by tidal currents as the water flows over the underwater dune-trough configuration. The banding observed by CZCS appears to be seasonal, following the sequence of primary production in the Gulf of Maine, and is believed to be important to biological processes as a site of new production and/or as an effective transport mechanism. Any future models that attempt to interrelate tidal mixing and primary production must consider bottom topography and secondary flows.

Community Environmental Response Facilitation Act (CERFA) report, Fort George G. Mead, Maryland. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schultheisz, D.; Ward, L.

1994-04-01

This report presents the results of the Community Environmental Response Facilitation Act (CERFA) investigation conducted by Environmental Resources Management (ERM) at Fort George G. Meade (FGGM), a U.S. Government property selected for closure by the Base Realignment and Closure (BRAC) Commission. Under CERFA, Federal agencies are required to expeditiously identify real property that can be immediately reused and redeveloped. Satisfying this objective requires the identification of real property where no hazardous substances or petroleum products, regulated by the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), were stored for one year or more, known to have been released, or disposed.more » Fort George G. Meade, CERFA, Base closure, BRAC.« less

America's Hero to the World, George C. Marshall. Second Edition.

ERIC Educational Resources Information Center

Skutt, Mary Sutton; Thompson, Rachel Yarnell

George C. Marshall (1880-1959), head of the U.S. Army in World War II, Secretary of State (1947-49), Secretary of Defense (1950-51), and Nobel Peace Prize winner (1953), was one of the late people as a child. He liked to play and was reasonably athletic, anxious to try out new ideas, and was particularly interested in history, but he was not…

Reconciling the Zagarola/Smits and George/Castillo Scaling for the Velocity Deficit

NASA Astrophysics Data System (ADS)

Wosnik, Martin; George, William K.

1998-11-01

Recently two new approaches to the scaling of the velocity deficit for boundary layers have been set forth. George and Castillo (1997)(George WK and Castillo L (1997) Appl.Mech.Rev.), 50, 12/1, 689--729. argue on theoretical grounds that the proper asymptotically invariant velocity deficit is given by (U-U_∞) = U_∞ f_o(y/δ, δ^+) where δ^+ = u* δ/ν. As δ^+ arrow ∞, f_o(y/δ,δ^+) arrow f_o∞(y/δ) thus only in this limit, which is well beyond existing experimental data, will profiles truly collapse. Similarly, the ratio, δ_*/δ is dependent on δ^+ and becomes constant only asymptotically. Zagarola and Smits (1998)(Zagarola M and Smits L (1998) in Proc. FEDSM, ASME, Wash., DC.), in apparent contradiction, show striking experimental collapse of the velocity deficit normalized with a new scale defined as Us = U_∞ δ_*/δ, where δ* is the displacement thickness. Both points of view are reconcilable. If it is assumed that f_o(y/δ,δ^+) = F(δ^+) f_o∞(y/δ), then the Zagarola/Smits result follows if F(δ^+) = δ_*/δ. This arbitrary splitting off of the Reynolds number dependence can only be justified approximately theoretically; however, the differences between this result and that calculated from the composite profile suggested by George and Castillo is almost impossible to discern over most of the outer flow. Hence both results are in essential agreement as to both the need for including the Reynolds number dependence in the velocity deficit and what it is.

The Role of RaxST, a Prokaryotic Sulfotransferase, and RaxABC, a Putative Type I Secretion System, in Activation of the Rice XA21-Mediated Immune Response

PubMed Central

Ronald, Pamela C.

2014-01-01

Tyrosine sulfation is an important posttranslational modification that determines the outcome of serious diseases in plants and animals. We have recently demonstrated that the plant pathogen Xanthomonas oryzae pv. oryzae (Xoo) carries a functional sulfotransferase (RaxST). raxST is required for activation of rice Xa21-mediated immunity indicating the critical, but unknown, function of raxST in mediating the Xoo/rice interaction. The raxST gene resides in the same operon (raxSTAB) as components of a predicted type I secretion and processing system (RaxA and RaxB). These observations suggest a model where RaxST sulfates a molecule that contains a leader peptide, which is cleaved by the peptidase domain of the RaxB protein and secreted outside the bacterial cell by the RaxABC T1SS. PMID:25386383

The Role of RaxST, a Prokaryotic Sulfotransferase, and RaxABC, a Putative Type I Secretion System, in Activation of the Rice XA21-Mediated Immune Response.

PubMed

Ronald, Pamela C

2014-01-01

Tyrosine sulfation is an important posttranslational modification that determines the outcome of serious diseases in plants and animals. We have recently demonstrated that the plant pathogen Xanthomonas oryzae pv. oryzae (Xoo) carries a functional sulfotransferase (RaxST). raxST is required for activation of rice Xa21-mediated immunity indicating the critical, but unknown, function of raxST in mediating the Xoo/rice interaction. The raxST gene resides in the same operon (raxSTAB) as components of a predicted type I secretion and processing system (RaxA and RaxB). These observations suggest a model where RaxST sulfates a molecule that contains a leader peptide, which is cleaved by the peptidase domain of the RaxB protein and secreted outside the bacterial cell by the RaxABC T1SS.

Promoting 21st-Century Skills in the Science Classroom by Adapting Cookbook Lab Activities: The Case of DNA Extraction of Wheat Germ

ERIC Educational Resources Information Center

Alozie, Nonye M.; Grueber, David J.; Dereski, Mary O.

2012-01-01

How can science instruction engage students in 21st-century skills and inquiry-based learning, even when doing simple labs in the classroom? We collaborated with teachers in professional development workshops to transform "cookbook" activities into engaging laboratory experiences. We show how to change the common classroom activity of DNA…

The Evolution of General Education Requirements at Prince George's Community College.

ERIC Educational Resources Information Center

Barshay, Robert; Cant, Catherine

In August 1981, a task force was created at Maryland's Prince George's Community College (PGCC) to analyze the college's General Education (GE) requirements in terms of their appropriateness as a major component of Associate Degree (AD) programs. Rather than increase the number of GE requirements, the task force sought to identify the skills,…

Biomass removal study on the George Washington and Jefferson National Forests

Treesearch

Dana Mitchell; John Klepac

2017-01-01

A study was installed on the George Washington National Forest to gather hardwood arvesting production data. The silvicultural prescription for the harvested unit was shelterwood with reserves. There was no biomass removal component included in this study. One purpose of this study was to gather baseline harvesting data for future comparisons of production impacts from...

Effects of bottom fishing on the benthic megafauna of Georges Bank

USGS Publications Warehouse

Collie, J.S.; Escanero, G.A.; Valentine, P.C.

1997-01-01

This study addresses ongoing concerns ever the effects of mobile fishing gear on benthic communities. Using side-scan sonar, bottom photographs and fishing records, we identified a set of disturbed and undisturbed sites on the gravel pavement area of northern Georges Bank in the northwest Atlantic. Replicate samples of the megofauna were collected with a 1 m Naturalists' dredge on 2 cruises in 1994. Compared with the disturbed sites, the undisturbed sites had higher numbers of organisms, biomass, species richness and species diversity; evenness was higher at the disturbed sites. Undisturbed sites were characterized by an abundance of bushy epifaunal taxa (bryozoans, hydroids, worm tubes) that provide a complex habitat for shrimps, polychaetes, brittle stars, mussels and small fish. Disturbed sites were dominated by larger, hard-shelled molluscs, and scavenging crabs and echinoderms. Many of the megafaunal species in our samples have also been identified in stomach contents of demersal fish on Georges Bank; the abundances of at feast some of these species were reduced at the disturbed sites.

A Comparison of the Operational Art of George Gordon Meade and Robert Edward Lee during the Period June 1863, to March 1864.

DTIC Science & Technology

1988-03-29

PERIOD COVERED A Comparison of the Operational Art of George G. Meade and Robert E. Lee During the Period Jun 1 8 6 3 Indiv study project to March...publication until it has been cleared by the appropriate military Service er gover"uent aency. A Comparison Of The Operational Art Of George Gordon...and/or Dis Speclal;! Sp ABSTRACT AUTHOR: THOMAS A. GREEN, LTC, AV. TITLE: A Comparison of the Operational Art of George Gordon Meade and Robert Edward

Practical Micro-Computer Uses in Physical Education at George Mason University.

ERIC Educational Resources Information Center

Stein, Julian U.

Both the Apple and TRS-80 microcomputer units are being used in the department of physical education at George Mason University (Virginia). As a first step, a computer program was developed and used in conjunction with an aerobic and personal conditioning class. (The capabilities of this specific program are discussed, and the ways in which it was…

The role of ST2 and ST2 genetic variants in schistosomiasis.

PubMed

Long, Xin; Daya, Michelle; Zhao, Jianping; Rafaels, Nicholas; Liang, Huifang; Potee, Joseph; Campbell, Monica; Zhang, Bixiang; Araujo, Maria Ilma; Oliveira, Ricardo R; Mathias, Rasika A; Gao, Li; Ruczinski, Ingo; Georas, Steve N; Vercelli, Donata; Beaty, Terri H; Barnes, Kathleen C; Chen, Xiaoping; Chen, Qian

2017-11-01

Chronic schistosomiasis and its severe complication, periportal fibrosis, are characterized by a predominant T h 2 response. To date, specific single nucleotide polymorphisms in ST2 have been some of the most consistently associated genetic variants for asthma. We investigated the role of ST2 (a receptor for the T h 2 cytokine IL-33) in chronic and late-stage schistosomiasis caused by Schistosoma japonicum and the potential effect of ST2 genetic variants on stage of disease and ST2 expression. We recruited 947 adult participants (339 with end-stage schistosomiasis and liver cirrhosis, 307 with chronic infections without liver fibrosis, and 301 health controls) from a S japonicum-endemic area (Hubei, China). Six ST2 single nucleotide polymorphisms were genotyped. Serum soluble ST2 (sST2) was measured by ELISA, and ST2 expression in normal liver tissues, Hepatitis B virus-induced fibrotic liver tissues, and S japonicum-induced fibrotic liver tissues was measured by immunohistochemistry. We found sST2 levels were significantly higher in the end-stage group (36.04 [95% CI, 33.85-38.37]) compared with chronic cases and controls (22.7 [95% CI, 22.0-23.4], P < 1E-10). In addition, S japonicum-induced fibrotic liver tissues showed increased ST2 staining compared with normal liver tissues (P = .0001). Markers rs12712135, rs1420101, and rs6543119 were strongly associated with sST2 levels (P = 2E-10, 5E-05, and 6E-05, respectively), and these results were replicated in an independent cohort from Brazil living in a S mansoni endemic region. We demonstrate for the first time that end-stage schistosomiasis is associated with elevated sST2 levels and show that ST2 genetic variants are associated with sST2 levels in patients with schistosomiasis. Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Georg Philip Nenter and medicine "by notes" in the 18th century.

PubMed

Bonfante, Luciana; D'Angelo, Angela; Komninos, Georgios; Antonello, Augusto

2009-01-01

Even though it is true that the medical historiography of the 18th century is lacking in great scientific personalities, it is equally true that the entire century is characterized by continuous efforts to encapsulate the medical area of knowledge, acquired until then, in precise and systematic outlines, to serve the academic teaching of the subject of medicine. Georg Philip Nenter, a pupil of Georg Ernst Stahl and a professor of medicine in the University of Strasburg, could not help being influenced by that atmosphere. He added though, in our opinion, a touch of remarkable modernity. In fact his volume Fundamenta medicinae teoretico-pratica (Venice, 1735) is a wonderful collection of the notes taken during his lectures. The description of various diseases - renal diseases in particular - maintains a very systematic development of the subject through various chapters (definition, clinical manifestations, differential diagnosis, prognosis, treatment and examples of specific prescriptions), as if students were being addressed.

50 CFR Table 14a to Part 679 - Port of Landing Codes 1, Alaska

Code of Federal Regulations, 2013 CFR

2013-10-01

... DUT Chefornak 189 CHF Chignik 113 CHG Cordova 115 COR Craig 116 CRG Dillingham 117 DIL Douglas 136 JNU... 168 SIT Skagway 169 SKG Soldotna 318 SOL St. George 170 STG St. Mary 319 STM St. Paul 172 STP Tee...

50 CFR Table 14a to Part 679 - Port of Landing Codes 1, Alaska

Code of Federal Regulations, 2014 CFR

2014-10-01

... DUT Chefornak 189 CHF Chignik 113 CHG Cordova 115 COR Craig 116 CRG Dillingham 117 DIL Douglas 136 JNU... 168 SIT Skagway 169 SKG Soldotna 318 SOL St. George 170 STG St. Mary 319 STM St. Paul 172 STP Tee...

50 CFR Table 14a to Part 679 - Port of Landing Codes 1, Alaska

Code of Federal Regulations, 2010 CFR

2010-10-01

... DUT Chefornak 189 CHF Chignik 113 CHG Cordova 115 COR Craig 116 CRG Dillingham 117 DIL Douglas 136 JNU... 168 SIT Skagway 169 SKG Soldotna 318 SOL St. George 170 STG St. Mary 319 STM St. Paul 172 STP Tee...

50 CFR Table 14a to Part 679 - Port of Landing Codes 1, Alaska

Code of Federal Regulations, 2012 CFR

2012-10-01

... DUT Chefornak 189 CHF Chignik 113 CHG Cordova 115 COR Craig 116 CRG Dillingham 117 DIL Douglas 136 JNU... 168 SIT Skagway 169 SKG Soldotna 318 SOL St. George 170 STG St. Mary 319 STM St. Paul 172 STP Tee...

50 CFR Table 14a to Part 679 - Port of Landing Codes 1, Alaska

Code of Federal Regulations, 2011 CFR

2011-10-01

... DUT Chefornak 189 CHF Chignik 113 CHG Cordova 115 COR Craig 116 CRG Dillingham 117 DIL Douglas 136 JNU... 168 SIT Skagway 169 SKG Soldotna 318 SOL St. George 170 STG St. Mary 319 STM St. Paul 172 STP Tee...

Collaboration and research as key elements for strengthening blood donation in developing nations: the case of Grenada, West Indies.

PubMed

Gomez, A; Messam, L L McV; Toner, L

2013-01-01

The purpose of the study was to identify ways to strengthen the collaboration between the Grenadian Blood Bank, the St George's University (SGU) chapter of the American Medical Students Association, and St George's University Health Clinic in order to improve the promotion of blood drives and increase the number of volunteer donors. The study had two phases. Phase 1: an assessment of the strengths and needs of the collaborators and of the blood drives. Phase 2 consisted of three student assessments: a cross-sectional survey of second year medical students, a cross-sectional survey of students in the School of Arts and Sciences and a case-control study of factors affecting student donation on the day of blood drives. Embedded within both phases were service-learning opportunities for students. Both phases received approval from SGU's Institutional Review Board. Preliminary achievements included a transient increase in blood donation of twenty per cent during five months though advertising of blood drives remains inadequate. Assessments reveal that most students lack knowledge about the drives, and time (medical students) and fear of needles and infection (Arts and Science students) are potential hindrances to blood donation. The Blood Bank needs to increase its profile on the university campus and develop a more effective promotion of the blood drives addressing the concerns of students. St George's University needs to continue supporting student involvement in health promotion activities and identify ways to ensure the sustainability and continuity of these activities. Collaboration and research are useful and effective means to promote blood donation. College students are potentially an excellent source of collaborators and donors if provided with the promotion skills and participation is made convenient.

St. John’s Wort enhances the synaptic activity of the nucleus of the solitary tract

PubMed Central

Vance, Katie M.; Ribnicky, David M.; Hermann, Gerlinda E.; Rogers, Richard C.

2014-01-01

Objective St. John’s Wort extract, which is commonly used to treat depression, inhibits the reuptake of several neurotransmitters, including glutamate, serotonin, norepinephrine, and dopamine. Glutamatergic visceral vagal afferents synapse upon neurons of the solitary tract (NST); thus, we evaluated whether St. John’s Wort extract modulates glutamatergic neurotransmission within the NST. Materials and Methods We used live cell calcium imaging to evaluate whether St. John’s Wort and its isolated components hypericin and hyperforin increase the excitability of pre-labeled vagal afferent terminals synapsing upon the NST. We used voltage-clamp recordings of spontaneous miniature excitatory postsynaptic currents (mEPSCs) to evaluate whether St. John’s Wort alters glutamate release from vagal afferents onto NST neurons. Results Our imaging data show that St. John’s Wort (50 μg/mL) increased the intracellular calcium levels of stimulated vagal afferent terminals compared to the bath control. This increase in presynaptic vagal afferent calcium by the extract coincides with an increase in neurotransmitter release within the nucleus of the solitary tract, as the frequency of mEPSCs is significantly higher in the presence of the extract compared to the control. Finally, our imaging data show that hyperforin, a known component of St. John’s Wort extract, also significantly increases terminal calcium levels. Conclusion These data suggest that St. John’s Wort extract can significantly increase the probability of glutamate release from vagal afferents onto the NST by increasing presynaptic calcium. The in vitro vagal afferent synapse with NST neurons is an ideal model system to examine the mechanism of action of botanical agents on glutamatergic neurotransmission. PMID:24985104

The Greening of St Patrick's.

ERIC Educational Resources Information Center

Barron, Jennie

1993-01-01

The grade 6-7 class at St. Patrick's School in Hamilton (Ontario) engages in outdoor environmental projects to enhance classroom learning. Some student activities have been (1) worm composting; (2) tree planting; (3) restoring tern nesting areas; and (4) planning and cultivating a sophisticated garden on school grounds. (KS)

Hyperforin, the active component of St. John's wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-kappaB-independent pathway.

PubMed

Zhou, Changcheng; Tabb, Michelle M; Sadatrafiei, Asal; Grün, Felix; Sun, Aixu; Blumberg, Bruce

2004-11-01

St. John's wort is widely used as an herbal antidepressant and is among the top-selling botanical products in the United States. Although St. John's wort has been reported to have minimal side effects compared with other antidepressants, here we show that hyperforin, the active component of St. John's wort, can stimulate interleukin-8 (IL-8) expression in human intestinal epithelia cells (IEC) and primary hepatocytes. Hyperforin is also able to induce expression of mRNA, encoding another major inflammatory mediator--intercellular adhesion molecule-1 (ICAM-1). IEC participate in the intestinal inflammatory process and serve as a first line of defense through bidirectional communication between host and infectious pathogens. Although hyperforin is a potent ligand for the steroid and xenobiotic receptor (SXR), we found that hyperforin induced IL-8 mRNA through an SXR-independent transcriptional activation pathway. IL-8 induction by hyperforin required the activation of AP-1 but not the NF-kappaB transcription factor, thereby distinguishing it from the NF-kappaB-dependent IL-8 induction mediated by tumor necrosis factor alpha (TNFalpha). Further study revealed that extracellular signal-regulated kinase 1 and 2 (ERK1/2) were required for the hyperforin-induced expression of IL-8. Our results suggest a previously unsuspected effect of St. John's wort in modulating the immune and inflammatory responses.

6. VIEW OF BRINING TANK Older, redwood model. Paddles agitated ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. VIEW OF BRINING TANK Older, redwood model. Paddles agitated the skins while they soaked in brine. The skins were then hung to dry. - Sealing Plant, St. George Island, Pribilof Islands, Saint George, Aleutians West Census Area, AK

Downscaling CMIP5 climate models shows increased tropical cyclone activity over the 21st century

PubMed Central

Emanuel, Kerry A.

2013-01-01

A recently developed technique for simulating large [O(104)] numbers of tropical cyclones in climate states described by global gridded data is applied to simulations of historical and future climate states simulated by six Coupled Model Intercomparison Project 5 (CMIP5) global climate models. Tropical cyclones downscaled from the climate of the period 1950–2005 are compared with those of the 21st century in simulations that stipulate that the radiative forcing from greenhouse gases increases by over preindustrial values. In contrast to storms that appear explicitly in most global models, the frequency of downscaled tropical cyclones increases during the 21st century in most locations. The intensity of such storms, as measured by their maximum wind speeds, also increases, in agreement with previous results. Increases in tropical cyclone activity are most prominent in the western North Pacific, but are evident in other regions except for the southwestern Pacific. The increased frequency of events is consistent with increases in a genesis potential index based on monthly mean global model output. These results are compared and contrasted with other inferences concerning the effect of global warming on tropical cyclones. PMID:23836646

GEORGE KEITH BATCHELOR 8 March 1920 30 March 2000 Founding Editor, Journal of Fluid Mechanics, 1956

NASA Astrophysics Data System (ADS)

Huppert, Herbert E.

2000-10-01

George Batchelor was one of the giants of fluid mechanics in the second half of the twentieth century. He had a passion for physical and quantitative understanding of fluid flows and a single-minded determination that fluid mechanics should be pursued as a subject in its own right. He once wrote that he ‘spent a lifetime happily within its boundaries’. Six feet tall, thin and youthful in appearance, George's unchanging attire and demeanour contrasted with his ever-evolving scientific insights and contributions. His strongly held and carefully articulated opinions, coupled with his forthright objectivity, shone through everything he undertook.

George Combe and common sense.

PubMed

Dyde, Sean

2015-06-01

This article examines the history of two fields of enquiry in late eighteenth- and early nineteenth-century Scotland: the rise and fall of the common sense school of philosophy and phrenology as presented in the works of George Combe. Although many previous historians have construed these histories as separate, indeed sometimes incommensurate, I propose that their paths were intertwined to a greater extent than has previously been given credit. The philosophy of common sense was a response to problems raised by Enlightenment thinkers, particularly David Hume, and spurred a theory of the mind and its mode of study. In order to succeed, or even to be considered a rival of these established understandings, phrenologists adapted their arguments for the sake of engaging in philosophical dispute. I argue that this debate contributed to the relative success of these groups: phrenology as a well-known historical subject, common sense now largely forgotten. Moreover, this history seeks to question the place of phrenology within the sciences of mind in nineteenth-century Britain.

76 FR 18725 - Marine Mammals; File Nos. 14330 and 14335

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-05

... (Phoca vitulina) on St. Paul, St. George, Otter, and Walrus Islands, and Sea Lion Rock, all of the... marine mammals in Alaska: (File No. 14330) the Aleut Community of St. Paul Island, Tribal Government, Ecosystem Conservation Office, St. Paul Island, AK; and (File No. 14335) the Alaska SeaLife Center, Seward...

Commitments: A Guide to Community Involvement Programs at The George Washington University.

ERIC Educational Resources Information Center

George Washington Univ., Washington, DC.

This guide to community involvement programs sponsored by the George Washington University provides a synopsis and a contact person for 33 general university programs, 38 medical school and hospital programs, eight National Law Center programs, eight School of Engineering and Applied Science programs, and two programs of the Division of…

Q&A with Nobelist George Smoot - 2009 BCCP Cosmology Workshop

ScienceCinema

George Smoot

2017-12-09

July 2009: What happens when dark matter and anti-dark mattter collide? If you were in a gravity free environment, what would happen to time? At the annual Cosmology Workshop at Lawrence Berkeley Lab, Nobelist George Smoot answers these questions and more from high school students and teachers. Dr. Smoot was co-awarded the 2006 Nobel Prize in Physics for the discovery of the blackbody form and anisotropy of the cosmic microwave background radiation.

Q&A with Nobelist George Smoot - 2009 BCCP Cosmology Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

George Smoot

2010-06-02

July 2009: What happens when dark matter and anti-dark mattter collide? If you were in a gravity free environment, what would happen to time? At the annual Cosmology Workshop at Lawrence Berkeley Lab, Nobelist George Smoot answers these questions and more from high school students and teachers. Dr. Smoot was co-awarded the 2006 Nobel Prize in Physics for the discovery of the blackbody form and anisotropy of the cosmic microwave background radiation.

Children's Access to Public Library Services: Prince George's County Memorial Public Library, Maryland, 1980.

ERIC Educational Resources Information Center

Gerhardt, Lillian N.

1981-01-01

Evaluates the Prince George's County Memorial Public Library's approach to providing access to its services for children, and examines policies, regulations, practices, and conditions that affect such access. Six references are cited. (FM)

7. VIEW OF BRINING TANK Newer, concrete model. After drying, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. VIEW OF BRINING TANK Newer, concrete model. After drying, skins were rolled in borax and packed into barrels, such as those seen in background. - Sealing Plant, St. George Island, Pribilof Islands, Saint George, Aleutians West Census Area, AK

Expression of Functional Human Sialyltransferases ST3Gal1 and ST6Gal1 in Escherichia coli

PubMed Central

Ortiz-Soto, Maria Elena; Seibel, Jürgen

2016-01-01

Sialyltransferases (STs) are disulfide-containing, type II transmembrane glycoproteins that catalyze the transfer of sialic acid to proteins and lipids and participate in the synthesis of the core structure oligosaccharides of human milk. Sialic acids are found at the outermost position of glycostructures, playing a key role in health and disease. Sialylation is also essential for the production of recombinant therapeutic proteins (RTPs). Despite their importance, availability of sialyltransferases is limited due to the low levels of stable, soluble and active protein produced in bacterial expression systems, which hampers biochemical and structural studies on these enzymes and restricts biotechnological applications. We report the successful expression of active human sialyltransferases ST3Gal1 and ST6Gal1 in commercial Escherichia coli strains designed for production of disulfide-containing proteins. Fusion of hST3Gal1 with different solubility enhancers and substitution of exposed hydrophobic amino acids by negatively charged residues (supercharging-like approach) were performed to promote solubility and folding. Co-expression of sialyltransferases with the chaperon/foldases sulfhydryl oxidase, protein disulfide isomerase and disulfide isomerase C was explored to improve the formation of native disulfide bonds. Active sialyltransferases fused with maltose binding protein (MBP) were obtained in sufficient amounts for biochemical and structural studies when expressed under oxidative conditions and co-expression of folding factors increased the yields of active and properly folded sialyltransferases by 20%. Mutation of exposed hydrophobic amino acids increased recovery of active enzyme by 2.5-fold, yielding about 7 mg of purified protein per liter culture. Functionality of recombinant enzymes was evaluated in the synthesis of sialosides from the β-d-galactoside substrates lactose, N-acetyllactosamine and benzyl 2-acetamido-2-deoxy-3-O

[George Nicholas Papanicolaou].

PubMed

Broso, P R; Buffetti, G

1993-10-01

G. N. Papanicolaou was born on May the 13, 1883 in the city of Kymi on the Greek island of Euboea. He received his MD degree from the University of Athens in 1904 and a PhD from the University of Munich in 1910. After service as a medical officer in the Balkan War of 1912-1913, he came to New York with Mary (for over 50 years Dr Pap's life companion). George's violin playing at restaurants and coffee-shops supplied them with a few extra cents. Papanicolaou was appointed assistant in the Pathology Laboratory at the New York Hospital. In 1928 he presented his work "New Cancer Diagnosis" to the third race betterment conference (Battle Creek, Michigan). But the work was met with scepticism. The now famous monograph "The Diagnostic Value of Vaginal Smears in Carcinoma of the Uterus" was published in 1941 in the Am J Obst Gyn. During this time, he developed his method of preservation of these cells by wet fixation and precise staining. Papanicolaou persisted with his ideas, and finally cytologic examination of the cervix was accepted. The power of Papanicolaou screening for uterine cancer was remarkable. The first National Cytology Congress, held in 1948, hailed this new diagnostic tool for carcinoma of the cervix as unique because it could detect cancer before it was visible. He described the importance of a distinct cellular pattern corresponding to cervical intraepithelial neoplastic lesions. The value of this pattern, expressing evolutionary steps in the development of cancer at individual cell levels, was not appreciated.(ABSTRACT TRUNCATED AT 250 WORDS)

The erudite humility of the historian: the 'critical epistemology' of Georges Lantéri-Laura.

PubMed

Basso Lorini, Elisabetta

2017-06-01

This paper analyses the historical and epistemological work of the French psychiatrist Georges Lantéri-Laura (1930-2004) within the context of the French 'tradition' of history and philosophy of sciences, with special reference to Georges Canguilhem and Michel Foucault. After an introduction devoted to a critical survey of the most recent works on the history and historiography of psychiatry in French, the paper outlines Lantéri-Laura's approach by focusing especially on the role played by the methodological concept of 'semiology' as regards the relation between medicine and psychiatry. The last part of the paper draws attention to the relation between the history and philosophy of psychiatry in light of Lantéri-Laura's 'critical epistemology'.

St. Laurent Construction Co., Inc. Information Sheet

EPA Pesticide Factsheets

St. Laurent Construction Co., Inc. (the Company) is located in Nashua, New Hampshire. The settlement involves renovation activities conducted at properties constructed prior to 1978, located in Merrimack and Nashua, New Hampshire.

3. VIEW OF KENCH TANK Used to preserve skins before ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. VIEW OF KENCH TANK Used to preserve skins before processing, the skins were placed in tanks in layers, alternating with salt. Some skins and salt remain. - Sealing Plant, St. George Island, Pribilof Islands, Saint George, Aleutians West Census Area, AK

Teaching for Transformation: Promoting Social Justice through Teaching: Interview with George Jacobs

ERIC Educational Resources Information Center

Yeo, Marie

2017-01-01

George Jacobs has taught English as a Second Language (ESL) and Teacher Education in many countries, including the US, China and Thailand. Since 1993, he has taught in Singapore, teaching for institutions including SEAMEO Regional Language Centre, Ministry of Education, and the National Institute of Education. He has also been teaching Writing at…

What Color Is Your Dog? Taking a Cue from Artist George Rodrigue

ERIC Educational Resources Information Center

Compton, June

2009-01-01

In this article, the author describes a lesson he created for his second-grade classes which was inspired by the children's book, "Why is Blue Dog Blue?", by George Rodrigue. In this lesson, the students make associations between places, food and events to determine the color of their dogs. (Contains 3 resources.)

Tetralogy of Fallot associated with deletion in the DiGeorge region of chromosome 22 (22q11)

DOE Office of Scientific and Technical Information (OSTI.GOV)

D`Angelo, J.A.; Pillers, D.M.; Jett, P.L.

Cardiac conotruncal defects, such as Tetralogy of Fallot (TOF), are associated with DiGeorge syndrome which has been mapped to the q11 region of chromosome 22 and includes abnormalities of neural crest and branchial arch development. Patients with conotruncal defects and velo-cardio-facial syndrome may have defects in the 22q11 region but not show the complete DiGeorge phenotype consisting of cardiac, thymus, and parathyroid abnormalities. We report two neonates with TOF and small deletions in the DiGeorge region of chromosome 22 (46,XX,del(22)(q11.21q11.23) and 46,XY,del(22)(q11.2q11.2)) using both high-resolution cytogenetics and fluorescence in situ hybridization (FISH). The first patient is a female with TOFmore » and a family history of congenital heart disease. The mother has pulmonic stenosis and a right-sided aortic arch, one brother has TOF, and a second brother has a large VSD. The patient had intrauterine growth retardation and had thrombocytopenia due to maternal IgG platelet-directed autoantibody. Lymphocyte populations, both T and B cells, were reduced in number but responded normally to stimulation. The findings were not attributed to a DiGeorge phenotype. Although she had transient neonatal hypocalcemia, her parathyroid hormone level was normal. The patient was not dysmorphic in the newborn period but her mother had features consistent with velo-cardio-facial syndrome. The second patient was a male with TOF who was not dysmorphic and had no other significant clinical findings and no family history of heart disease. Lymphocyte testing did not reveal a specific immunodeficiency. No significant postnatal hypocalcemia was noted. These cases illustrate that there is a wide spectrum of clinical features associated with defects of the 22q11 region. We recommend karyotype analysis, including FISH probes specific to the DiGeorge region, in any patient with conotruncal cardiac defects.« less

A 3000 yr paleostorm record from St. Catherines Island, Georgia

NASA Astrophysics Data System (ADS)

Braun, Erick; Meyer, Brian; Deocampo, Daniel; Kiage, Lawrence M.

2017-09-01

Tropical cyclones (hurricanes in the northern hemisphere) are amongst the most devastating of the world's natural disasters and cause billions of dollars in damage every year. Data on the likelihood of a coastal site being struck by a major hurricane strike can potentially aid in planning and mitigation efforts that could save money and lives. However, forecasting requires data that are currently insufficient for the Georgia Bight. This study provides information to enhance the paleohurricane record by analysis of a 467 cm thick vibracore raised from St. Catherines Island, GA. Sediment geochemistry and foraminiferal assemblages indicate deposits attributable to seven paleohurricane events, five of which were likely major hurricanes when they made landfall on St. Catherines. Magnitudes were estimated by comparison to the overwash deposit left by ;The Sea Islands hurricane of 1893;, a major hurricane recorded by the recent sediment of St. Catherines Island. The St. Catherines record also shows a change in the activity levels on the Georgia coast with two distinct activity regimes over the past 3000 years.

Outreach activities in support of the Missouri S&T national UTC.

DOT National Transportation Integrated Search

2010-02-01

This report describes a comprehensive initiative providing outreach for the Missouri University of Science and Technology (Missouri S&T) National University Transportation Center (NUTC). The goal of this comprehensive outreach program was to provide ...

Strengthening Links between Evaluation Theory and Practice, and More: Comments Inspired by George Grob's 2017 Eleanor Chelimsky Forum Presentation

ERIC Educational Resources Information Center

Mark, Melvin M.

2018-01-01

George Grob presented the fifth and final Eleanor Chelimsky Forum address at the 2017 annual meeting of the Eastern Evaluation Research Society. In this commentary, I respond to several points that George raises in the "American Journal of Evaluation" paper based on that address. An overarching theme of my comments involves the potential…

EAARL Topography - George Washington Birthplace National Monument 2008

USGS Publications Warehouse

Brock, John C.; Nayegandhi, Amar; Wright, C. Wayne; Stevens, Sara; Yates, Xan

2009-01-01

These remotely sensed, geographically referenced elevation measurements of Lidar-derived bare earth (BE) and first surface (FS) topography were produced as a collaborative effort between the U.S. Geological Survey (USGS), Florida Integrated Science Center (FISC), St. Petersburg, FL; the National Park Service (NPS), Northeast Coastal and Barrier Network, Kingston, RI; and the National Aeronautics and Space Administration (NASA), Wallops Flight Facility, VA. This project provides highly detailed and accurate datasets of the George Washington Birthplace National Monument in Virginia, acquired on March 26, 2008. The datasets are made available for use as a management tool to research scientists and natural resource managers. An innovative airborne Lidar instrument originally developed at the NASA Wallops Flight Facility, and known as the Experimental Advanced Airborne Research Lidar (EAARL) was used during data acquisition. The EAARL system is a raster-scanning, waveform-resolving, green-wavelength (532-nanometer) Lidar designed to map near-shore bathymetry, topography, and vegetation structure simultaneously. The EAARL sensor suite includes the raster-scanning, water-penetrating full-waveform adaptive Lidar, a down-looking red-green-blue (RGB) digital camera, a high-resolution multi-spectral color infrared (CIR) camera, two precision dual-frequency kinematic carrier-phase GPS receivers, and an integrated miniature digital inertial measurement unit, which provide for submeter georeferencing of each laser sample. The nominal EAARL platform is a twin-engine Cessna 310 aircraft, but the instrument may be deployed on a range of light aircraft. A single pilot, a Lidar operator, and a data analyst constitute the crew for most survey operations. This sensor has the potential to make significant contributions in measuring sub-aerial and submarine coastal topography within cross-environmental surveys. Elevation measurements were collected over the survey area using the EAARL

75 FR 51945 - Safety Zone; Potomac River, St. Mary's River, St. Inigoes, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-24

...-AA00 Safety Zone; Potomac River, St. Mary's River, St. Inigoes, MD AGENCY: Coast Guard, DHS. ACTION... of the St. Mary's River, a tributary of the Potomac River. This action is necessary to provide for.... Navy helicopter located near St. Inigoes, Maryland. This safety zone is intended to protect the...

Prince George's Community College and the Fiscal Crisis of the 1990's.

ERIC Educational Resources Information Center

Clagett, Craig

Declining state support and insufficient increases in county contributions have created a severe fiscal challenge to Prince George's Community College (PGCC), in Maryland. Total state aid in fiscal year (FY) 1995 was $857,189 less than in FY 1990, while in FY 1994 PGCC also began assuming responsibility for social security payments previously paid…

Student Retention at Prince George's Community College. Research Brief RB89-6.

ERIC Educational Resources Information Center

Clagett, Craig A.

A study was conducted at Prince George's Community College (PGCC) to examine student retention in two ways. First, the percentage of fall 1987 students who returned for classes the following spring was calculated for several student groups. Second, students entering PGCC for the first time in 1980 were tracked in terms of attendance and degree…

75 FR 80372 - Proposed Amendment of Restricted Areas R-2907A and R-2907B, Lake George, FL; and R-2910...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-22

...-1146; Airspace Docket No. 10-ASO-25] Proposed Amendment of Restricted Areas R-2907A and R-2907B, Lake George, FL; and R-2910, Pinecastle, FL AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice... limits of restricted areas R-2907A and R-2907B, Lake George, FL; and restricted area R-2910, Pinecastle...

Birth of the first ESS: George Price, John Maynard Smith, and the discovery of the lost "Antlers" paper.

PubMed

Harman, Oren

2011-01-15

The application of game theory to evolutionary problems is so commonplace today, that few stop to consider how it all began. John Maynard Smith and George R. Price's 1973 Nature article, "The Logic of Animal Conflict," is often referred to as the first description in the literature of the concept of an evolutionary stable strategy (ESS), but what was the "behind the scenes" of the writing of that seminal paper? This article tracks the little known story of the curious American polymath, George Price. As will be shown, it was an earlier paper, the lost "Antlers, Intraspecific Combat, and Altruism," sent by Price to Nature in August 1968 (Unpublished), and refereed by Maynard Smith, which instigated the birth of the first ESS. Recently, the "Antlers" paper has been re-discovered by the author, shedding new light, together with letters and journals from the personal papers of George Price and John Maynard Smith, on their historical paper. © 2010 Wiley-Liss, Inc.

Impacts of exploratory drilling for oil and gas on the benthic environment of Georges Bank

USGS Publications Warehouse

Neff, J. M.; Bothner, Michael H.; Maciolek, N. J.; Grassle, J. F.

1989-01-01

Cluster analysis revealed a strong relationship between community structure and both sediment type and water depth. Little seasonal variation was detected, but some interannual differences were revealed by cluster analysis and correspondence analysis. The replicates from a station always resembled each other more than they resembled any replicates from other stations. In addition, the combined replicates from a station always clustered with samples from that station taken on other cruises. This excellent replication and uniformity of the benthic infaunal community at a station over time made it possible to detect very subtle changes in community parameters that might be related to discharges of drilling fluid and drill cuttings. Nevertheless, no changes were detected in benthic communities of Georges Bank that could be attributed to drilling activities.

Localization of the human mitochondrial citrate transporter protein gene to chromosome 22q11 in the DiGeorge syndrome critical region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heisterkamp, N.; Hoeve, J.T.; Groffen, J.

A high percentage of patients with DiGeorge syndrome and velo-cardio-facial syndrome have interstitial deletions on chromosome 22q11. The shortest region of overlap is currently estimated to be around 500 kb. Two segments of DNA from chromosome 22q11, located 160 kb apart, were cloned because they contained NotI restriction enzyme sites. In the current study we demonstrate that these segments are absent from chromosomes 22 carrying microdeletions of two different DiGeorge patients. Fluorescence in situ and Southern blot hybridization was further used to show that this locus is within the DiGeorge critical region. Phylogenetically conserved sequences adjacent to one of themore » two NotI sites hybridized to mRNAs in different human cell lines. cDNAs isolated with a probe from this segment showed it to contain the gene for the human mitochondrial citrate transporter protein. Deletion of this gene in DiGeorge may contribute to the mental deficiency seen in the patients. 35 refs., 5 figs.« less

33 CFR 110.182 - Atlantic Ocean off Fort George Inlet, near Mayport, Fla.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Atlantic Ocean off Fort George Inlet, near Mayport, Fla. 110.182 Section 110.182 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.182 Atlantic Ocean...

33 CFR 110.182 - Atlantic Ocean off Fort George Inlet, near Mayport, Fla.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Atlantic Ocean off Fort George Inlet, near Mayport, Fla. 110.182 Section 110.182 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.182 Atlantic Ocean...

33 CFR 110.182 - Atlantic Ocean off Fort George Inlet, near Mayport, Fla.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Atlantic Ocean off Fort George Inlet, near Mayport, Fla. 110.182 Section 110.182 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.182 Atlantic Ocean...

33 CFR 110.182 - Atlantic Ocean off Fort George Inlet, near Mayport, Fla.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Atlantic Ocean off Fort George Inlet, near Mayport, Fla. 110.182 Section 110.182 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.182 Atlantic Ocean...

33 CFR 110.182 - Atlantic Ocean off Fort George Inlet, near Mayport, Fla.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Atlantic Ocean off Fort George Inlet, near Mayport, Fla. 110.182 Section 110.182 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.182 Atlantic Ocean...

Feature-oriented regional modeling and simulations in the Gulf of Maine and Georges Bank

NASA Astrophysics Data System (ADS)

Gangopadhyay, Avijit; Robinson, Allan R.; Haley, Patrick J.; Leslie, Wayne G.; Lozano, Carlos J.; Bisagni, James J.; Yu, Zhitao

2003-03-01

The multiscale synoptic circulation system in the Gulf of Maine and Georges Bank (GOMGB) region is presented using a feature-oriented approach. Prevalent synoptic circulation structures, or 'features', are identified from previous observational studies. These features include the buoyancy-driven Maine Coastal Current, the Georges Bank anticyclonic frontal circulation system, the basin-scale cyclonic gyres (Jordan, Georges and Wilkinson), the deep inflow through the Northeast Channel (NEC), the shallow outflow via the Great South Channel (GSC), and the shelf-slope front (SSF). Their synoptic water-mass ( T- S) structures are characterized and parameterized in a generalized formulation to develop temperature-salinity feature models. A synoptic initialization scheme for feature-oriented regional modeling and simulation (FORMS) of the circulation in the coastal-to-deep region of the GOMGB system is then developed. First, the temperature and salinity feature-model profiles are placed on a regional circulation template and then objectively analyzed with appropriate background climatology in the coastal region. Furthermore, these fields are melded with adjacent deep-ocean regional circulation (Gulf Stream Meander and Ring region) along and across the SSF. These initialization fields are then used for dynamical simulations via the primitive equation model. Simulation results are analyzed to calibrate the multiparameter feature-oriented modeling system. Experimental short-term synoptic simulations are presented for multiple resolutions in different regions with and without atmospheric forcing. The presented 'generic and portable' methodology demonstrates the potential of applying similar FORMS in many other regions of the Global Coastal Ocean.

The Space-Age Legacy of Telescope Designer George A. Carroll

NASA Astrophysics Data System (ADS)

Briggs, John W.

2013-01-01

Remembered particularly as a founding member of Stony Ridge Observatory near Mount Wilson, George A. Carroll (1902-1987) was legendary in the Southern California telescope making community. In Texas at the age of sixteen, Carroll built and flew his own aircraft, becoming one of the youngest aviators in the country. He eventually became an employee of Lockheed's "Skunk Works" in Burbank. His earliest known commercial telescopes were high-end amateur instruments built by R. R. Cook. As described in a brochure describing his later telescope work, he had "experience in so many branches of technology that it is unbelievable." By the time Carroll's designs were built by Thomas Tool & Die in Sun Valley, his telescopes were well known in the solar community and in use at National Solar Observatory, Caltech, and at many other domestic and international research institutions. Among the most remarkable were large solar spars for Lockheed Solar Observatory in California and Ottawa River Solar Observatory in Canada. His instrumentation also equipped educational facilities including observatories at UCLA, Westmont College, Pasadena City College, Bevard Community College, and many others. A Carroll telescope boasting a particularly distinguished educational history was a small astrograph built in 1953 for Professor George Moyen of Hollywood and subsequently used for the long-running Summer Science Program in Ojai, California. Later solar instruments built by Carson Instruments were closely derivative of Carroll designs.

Georges Sagnac: A life for optics

NASA Astrophysics Data System (ADS)

Darrigol, Olivier

2014-12-01

Georges Sagnac is mostly known for the optical effect in rotating frames that he demonstrated in 1913. His scientific interests were quite diverse: they included photography, optical illusions, X-ray physics, radioactivity, the blue of the sky, anomalous wave propagation, interferometry, strioscopy, and acoustics. An optical theme nonetheless pervaded his entire œuvre. Within optics, an original theory of the propagation of light motivated most of his investigations, from an ingenious explanation of the Fresnel drag, through the discovery of the Sagnac effect, to his quixotic defense of an alternative to relativity theory. Optical analogies efficiently guided his work in other domains. Optics indeed was his true passion. He saw himself as carrying the torch of the two great masters of French optics, Augustin Fresnel and Hippolyte Fizeau. In this mission he overcame his poor health and labored against the modernist tide, with much success originally and bitter isolation in the end. xml:lang="fr"

UMCS feasibility study for Fort George G. Meade volume 1. Feasibility study

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-12-01

Fort George G. Meade selected 83 buildings, from the approximately 1,500 buildings on the base to be included in the UMCS Feasibility Study. The purpose of the study is to evaluate the feasibility of replacing the existing analog based Energy Monitoring and Control System (EMCS) with a new distributed process Monitoring and Control System (UMCS).

Ernst Mach, George Sarton and the Empiry of Teaching Science Part I

ERIC Educational Resources Information Center

Siemsen, Hayo

2012-01-01

George Sarton had a strong influence on modern history of science. The method he pursued throughout his life was the method he had discovered in Ernst Mach's "Mechanics" when he was a student in Ghent. Sarton was in fact throughout his life implementing a research program inspired by the epistemology of Mach. Sarton in turn inspired many…

Spring evolution of Pseudocalanus spp. abundance on Georges Bank based on molecular discrimination of P. moultoni and P. newmani1

NASA Astrophysics Data System (ADS)

Bucklin, Ann; Guarnieri, Maria; McGillicuddy, Dennis J.; Sean Hill, R.

The planktonic copepod sibling species Pseudocalanus moultoni and P. newmani (Crustacea, Copepoda) are abundant in waters over Georges Bank from late winter until mid-summer and are thought to reproduce throughout this period. The two species cannot be reliably distinguished using morphological characters, but are readily identified and distinguished by simple, rapid, and inexpensive molecular protocols based on sequence variation of mitochondrial DNA (mtDNA). DNA sequence variation of a portion of the mitochondrial cytochrome oxidase I (mtCOI) confirmed the presence of P. moultoni and P. newmani on Georges Bank; the mtCOI sequences were used to design species-specific oligonucleotide primers for use in a competitive multiplexed species-specific polymerase chain reaction (PCR). Species-specific PCR was used to determine the relative abundances of the two species in sub-samples of zooplankton collections from US GLOBEC Georges Bank Study Broadscale Surveys from February to June, 1997. Based on monthly visualizations, we inferred the spring evolution of the two species' distributions and abundances on Georges Bank. Both species' overall abundances increased from February to May or June: maximum abundance of P. moultoni was 38,061 m -2 in surface waters on the crest of Georges Bank in June; maximum abundance of P. newmani was 13,854 m -2 in subsurface waters on the Northeast Peak in April. The Peak in distribution of P. moultoni shifted from Georges Basin in April, to the northern edge of the Bank in May, to the center of the Bank in June. In contrast, P. newmani was more abundant to the south and east of the Bank. Beginning in April, P. newmani occurred on the Bank but was less abundant and less widely-distributed than P. moultoni; P. newmani abundance peaked in May and declined somewhat in June. Females of the species differed in their patterns of distribution and abundance, with P. moultoni always the more abundant species on the crest of the Bank. The spring

George M. Low Trophy NASA's Quality and Excellence Award, 1992. Application guidelines: Small business

NASA Technical Reports Server (NTRS)

1992-01-01

Guidelines are given for the selection of small business candidates for the George M. Low Trophy, NASA's Quality and Excellence Award, 1992. Topics covered include candidate eligibility, the selection process milestone schedule, the nomination letter, and the application report.

[Reception of Johann Georg Zimmermann's manuscripts in Montpellier].

PubMed

Lohff, B

1997-01-01

At the end of the 18th century the French physicians discussed Johann Georg Zimmermann's medical concepts (i.e. medical experience, the influence of the soul on health and disease). In contrast to the German scientists, the French, especially those from the School of Montpellier, accepted Zimmermann's medical views as a confirmation of vitalism and neohippocratic medicine. In Germany, Zimmermann's medical works fell into oblivion after his death until the middle of 20th century. This may be a consequence of his intimate contacts to the European high nobility and of his polemic attacks against friends and enemies as well as his contempt for all forms of democracy and the French Revolution.

An antibacterial and antiviral peptide produced by Enterococcus mundtii ST4V isolated from soya beans.

PubMed

Todorov, Svetoslav D; Wachsman, Mónica B; Knoetze, Hendriëtte; Meincken, Martina; Dicks, Leon M T

2005-06-01

Enterococcus mundtii ST4V, isolated from soya beans, produces a 3950Da antibacterial peptide active against Gram-positive and Gram-negative bacteria, including Enterococcus faecalis, Streptococcus spp., Pseudomonas aeruginosa, Klebsiella pneumoniae, Streptococcus pneumoniae and Staphylococcus aureus. The peptide also inactivated the herpes simplex viruses HSV-1 (strain F) and HSV-2 (strain G), a polio virus (PV3, strain Sabin) and a measles virus (strain MV/BRAZIL/001/91, an attenuated strain of MV). MV, HSV-1 and HSV-2 were 95.5%-99.9% inactivated by peptide ST4V at 400 microg/ml. Monkey kidney Vero cells were not inactivated, even at four times the level peptide ST4V displayed antiviral activity, indicating that the effect was not due to cytotoxicity. Complete inactivation or significant reduction in antimicrobial activity was observed after treatment of peptide ST4V with Proteinase K, pronase, pepsin and trypsin. No change in antimicrobial activity was recorded after treatment with alpha-amylase, suggesting that peptide ST4V was not glycosylated. This is the first description of an antibacterial and antiviral peptide with such broad-spectrum of activity, produced by a lactic acid bacterium.

Survey of Laser-Produced Pressure and Impulse Data

DTIC Science & Technology

1988-01-01

Marseille, Marseille, France; C.E.A. Limeil-Service H.D.E., St. Georges , France Experimental Conditions: Laser: TEA C02 Wavelength: 10.6 pm Pulse energy: to...Mecanique des Fluides de Marseille, Marseille, France; C.E.A. Limeil-Service H.D.E., St. Georges , France Experimental Conditions: Laser: TEA CO2 Wavelength...34 Authors : C.L. Bohn, M.D. Stephen, F. Eng, J.C. Souders, G.A. Brost , T.F. Deaton, B.W. Duvall, and J.T. Tinsley Citation: "Mechanical coupling of an

Steroidogenic acute regulatory protein (StAR) overexpression attenuates HFD-induced hepatic steatosis and insulin resistance.

PubMed

Qiu, Yanyan; Sui, Xianxian; Zhan, Yongkun; Xu, Chen; Li, Xiaobo; Ning, Yanxia; Zhi, Xiuling; Yin, Lianhua

2017-04-01

Non-alcoholic fatty liver disease (NAFLD) covers a wide spectrum of liver pathology. Intracellular lipid accumulation is the first step in the development and progression of NAFLD. Steroidogenic acute regulatory protein (StAR) plays an important role in the synthesis of bile acid and intracellular lipid homeostasis and cholesterol metabolism. We hypothesize that StAR is involved in non-alcoholic fatty liver disease (NAFLD) pathogenesis. The hypothesis was identified using free fatty acid (FFA)-overloaded NAFLD in vitro model and high-fat diet (HFD)-induced NAFLD mouse model transfected by recombinant adenovirus encoding StAR (StAR). StAR expression was also examined in pathology samples of patients with fatty liver by immunohistochemical staining. We found that the expression level of StAR was reduced in the livers obtained from fatty liver patients and NAFLD mice. Additionally, StAR overexpression decreased the levels of hepatic lipids and maintained the hepatic glucose homeostasis due to the activation of farnesoid x receptor (FXR). StAR overexpression attenuated the impairment of insulin signaling in fatty liver. This protective role of StAR was owing to a reduction of intracellular diacylglycerol levels and the phosphorylation of PKCε. Furthermore, FXR inactivation reversed the observed beneficial effects of StAR. The present study revealed that StAR overexpression can reduce hepatic lipid accumulation, regulate glucose metabolism and attenuate insulin resistance through a mechanism involving the activation of FXR. Our study suggests that StAR may be a potential therapeutic target for NAFLD. Copyright © 2017 Elsevier B.V. All rights reserved.

sST2 translation is regulated by FGF2 via an hnRNP A1-mediated IRES-dependent mechanism.

PubMed

Kunze, Michael M; Benz, Fabienne; Brauß, Thilo F; Lampe, Sebastian; Weigand, Julia E; Braun, Johannes; Richter, Florian M; Wittig, Ilka; Brüne, Bernhard; Schmid, Tobias

2016-07-01

Translation is an energy-intensive process and tightly regulated. Generally, translation is initiated in a cap-dependent manner. Under stress conditions, typically found within the tumor microenvironment in association with e.g. nutrient deprivation or hypoxia, cap-dependent translation decreases, and alternative modes of translation initiation become more important. Specifically, internal ribosome entry sites (IRES) facilitate translation of specific mRNAs under otherwise translation-inhibitory conditions. This mechanism is controlled by IRES trans-acting factors (ITAF), i.e. by RNA-binding proteins, which interact with and determine the activity of selected IRESs. We aimed at characterizing the translational regulation of the IL-33 decoy receptor sST2, which was enhanced by fibroblast growth factor 2 (FGF2). We identified and verified an IRES within the 5'UTR of sST2. Furthermore, we found that MEK/ERK signaling contributes to FGF2-induced, sST2-IRES activation and translation. Determination of the sST2-5'UTR structure by in-line probing followed by deletion analyses identified 23 nucleotides within the sST2-5'UTR to be required for optimal IRES activity. Finally, we show that the RNA-binding protein heterogeneous ribonucleoprotein A1 (hnRNP A1) binds to the sST2-5'UTR, acts as an ITAF, and thus controls the activity of the sST2-IRES and consequently sST2 translation. Specifically, FGF2 enhances nuclear-cytoplasmic translocation of hnRNP A1, which requires intact MEK/ERK activity. In summary, we provide evidence that the sST2-5'UTR contains an IRES element, which is activated by a MEK/ERK-dependent increase in cytoplasmic localization of hnRNP A1 in response to FGF2, enhancing the translation of sST2. Copyright © 2016 Elsevier B.V. All rights reserved.

Effects of Hurricane Georges on habitat use by captive-reared Hispaniolan Parrots (Amazona ventralis) released in the Dominican Republic

USGS Publications Warehouse

White, T.H.; Collazo, J.A.; Vilella, F.J.; Guerrero, S.A.

2005-01-01

We radio-tagged and released 49 captive-reared Hispaniolan Parrots (Amazona ventralis) in Parque Nacional del Este (PNE), Dominican Republic, during 1997 and 1998. Our primary objective was to develop a restoration program centered on using aviary-reared birds to further the recovery of the critically endangered Puerto Rican Parrot (A. vittata). Hurricane Georges made landfall over the release area on 22 September 1998 with sustained winds of 224 km/h, providing us with a unique opportunity to quantify responses of parrots to such disturbances. Quantitative data on such responses by any avian species are scarce, particularly for Amazona species, many of which are in peril and occur in hurricane-prone areas throughout the Caribbean. Mean home ranges of 18 parrots monitored both before and after the hurricane increased (P = 0.08) from 864 ha (CI = 689-1039 ha) pre-hurricane to 1690 ha (CI = 1003-2377 ha) post-hurricane. The total area traversed by all parrots increased > 300%, from 4884 ha pre-hurricane to 15,490 ha post-hurricane. Before Hurricane Georges, parrot activity was concentrated in coastal scrub, tall broadleaf forest, and abandoned agriculture (conucos). After the hurricane, parrots concentrated their activities in areas of tall broadleaf forest and abandoned conucos. Topographic relief, primarily in the form of large sinkholes, resulted in "resource refugia" where parrots and other frugivores foraged after the hurricane. Habitat use and movement patterns exhibited by released birds highlight the importance of carefully considering effects of season, topography, and overall size of release areas when planning psittacine restorations in hurricane-prone areas. ?? The Neotropical Ornithological Society.

Seismic evidence for a cold serpentinized mantle wedge beneath Mount St Helens

PubMed Central

Hansen, S. M.; Schmandt, B.; Levander, A.; Kiser, E.; Vidale, J. E.; Abers, G. A.; Creager, K. C.

2016-01-01

Mount St Helens is the most active volcano within the Cascade arc; however, its location is unusual because it lies 50 km west of the main axis of arc volcanism. Subduction zone thermal models indicate that the down-going slab is decoupled from the overriding mantle wedge beneath the forearc, resulting in a cold mantle wedge that is unlikely to generate melt. Consequently, the forearc location of Mount St Helens raises questions regarding the extent of the cold mantle wedge and the source region of melts that are responsible for volcanism. Here using, high-resolution active-source seismic data, we show that Mount St Helens sits atop a sharp lateral boundary in Moho reflectivity. Weak-to-absent PmP reflections to the west are attributed to serpentinite in the mantle-wedge, which requires a cold hydrated mantle wedge beneath Mount St Helens (<∼700 °C). These results suggest that the melt source region lies east towards Mount Adams. PMID:27802263

Q and A with Nobelist George Smoot - 2009 BCCP Cosmology Workshop

ScienceCinema

Smoot, George

2018-01-24

July 2009: What happens when dark matter and anti-dark mattter collide? If you were in a gravity free environment, what would happen to time? At the annual Cosmology Workshop at Lawrence Berkeley Lab, Nobelist George Smoot answers these questions and more from high school students and teachers. Dr. Smoot was co-awarded the 2006 Nobel Prize in Physics for the discovery of the blackbody form and anisotropy of the cosmic microwave background radiation.

Q and A with Nobelist George Smoot - 2009 BCCP Cosmology Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smoot, George

2010-01-01

July 2009: What happens when dark matter and anti-dark mattter collide? If you were in a gravity free environment, what would happen to time? At the annual Cosmology Workshop at Lawrence Berkeley Lab, Nobelist George Smoot answers these questions and more from high school students and teachers. Dr. Smoot was co-awarded the 2006 Nobel Prize in Physics for the discovery of the blackbody form and anisotropy of the cosmic microwave background radiation.

Pictorial account and landscape evolution of the crevasses near Fort St. Philip, Louisiana

USGS Publications Warehouse

Suir, Glenn M.; Jones, William R.; Garber, Adrienne L.; Barras, John A.

2014-01-01

Quantifying the effects of active natural and constructed crevasses is critical to the planning and success of future ecosystem restoration activities. This document provides a historical overview of landscape changes within the vicinity of the natural crevasses near Fort St. Philip, Louisiana. A significant event influencing landscape change within the Fort St. Philip study area was the breaching of the eastern levee of the Mississippi River. Initially, the river water that was diverted through these crevasse channels physically removed significant marsh areas within the study area. These initial direct impacts were succeeded by several decades of larger regional loss patterns driven by subsidence and other episodic events (e.g, hurricanes and floods), and recent localized land gains. These increases in land area are potentially the long-term results of the Fort St. Philip crevasses, and the short-term impacts of delta management activities. However, for the majority of the 1956-2008 period of analysis, the crevassing of the eastern bank of the Mississippi River levee was a loss accelerant in the Fort St. Philip area.

ST2 and IL-33 in Pregnancy and Pre-Eclampsia

PubMed Central

Snider, James V.; Tannetta, Dionne S.; Child, Tim; Redman, Christopher W. G.; Sargent, Ian L.

2011-01-01

Normal pregnancy is associated with a mild systemic inflammatory response and an immune bias towards type 2 cytokine production, whereas pre-eclampsia is characterized by a more intense inflammatory response, associated with endothelial dysfunction and a type 1 cytokine dominance. Interleukin (IL)-33 is a newly described member of the IL-1 family, which binds its receptor ST2L to induce type 2 cytokines. A soluble variant of ST2 (sST2) acts as a decoy receptor to regulate the activity of IL-33. In this study circulating IL-33 and sST2 were measured in each trimester of normal pregnancy and in women with pre-eclampsia. While IL-33 did not change throughout normal pregnancy, or between non-pregnant, normal pregnant or pre-eclamptic women, sST2 was significantly altered. sST2 was increased in the third trimester of normal pregnancy (p<0.001) and was further increased in pre-eclampsia (p<0.001). This increase was seen prior to the onset of disease (p<0.01). Pre-eclampsia is a disease caused by placental derived factors, and we show that IL-33 and ST2 can be detected in lysates from both normal and pre-eclampsia placentas. ST2, but not IL-33, was identified on the syncytiotrophoblast layer, whereas IL-33 was expressed on perivascular tissue. In an in vitro placental perfusion model, sST2 was secreted by the placenta into the ‘maternal’ eluate, and placental explants treated with pro-inflammatory cytokines or subjected to hypoxia/reperfusion injury release more sST2, suggesting the origin of at least some of the increased amounts of circulating sST2 in pre-eclamptic women is the placenta. These results suggest that sST2 may play a significant role in pregnancies complicated by pre-eclampsia and increased sST2 could contribute to the type 1 bias seen in this disorder. PMID:21949719

George W. Bush at Goree Island: American Slavery and the Rhetoric of Redemption

ERIC Educational Resources Information Center

Medhurst, Martin J.

2010-01-01

On July 8, 2003, at Goree Island, Senegal, George W. Bush delivered the most important speech on American slavery since Abraham Lincoln. As an example of rhetorical artistry, the speech is a masterpiece, putting the brutality of slavery into historical, political, and theological perspective. Although the speech had deliberative effects--it grew…

21st Century Power Partnership: September 2016 Fellowship Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reber, Timothy J.; Rambau, Prudence; Mdhluli, Sipho

This report details the 21st Century Power Partnership fellowship from September 2016. This Fellowship is a follow-up to the Technical Audit of Eskom's Medium- and Long-term Modelling Capabilities, conducted by U.S. National Renewable Energy Laboratory (NREL) in April 2016. The prospect and role of variable renewable energy (vRE) in South Africa poses new modelling-related challenges that Eskom is actively working to address by improving the fidelity of PLEXOS LT and ST models.

The Munson-Nygren slide: A major lower-slope slide off Georges Bank

USGS Publications Warehouse

O'Leary, Dennis W.

1986-01-01

The Munson-Nygren slide is a large compound slide located between Munson and Nygren Canyons below 1900 m depth on the Continental Slope off Georges Bank. Its structural and morphological features are recognized in high-resolution seismic-reflection profiles. The slide comprises an axial trough which has a relief as great as 325 m and a width of 6-10 km. The trough is flanked by displaced and disrupted strata for a total lateral extent of approximately 20 km and a downslope extent of at least 35 km. The slide is unrelated genetically to the adjacent canyons and may postdate Munson Canyon. There is evidence of plastic deformation at the base of the section subjected to sliding. Certain features of the slide complex resemble those seen in landforms on the Laurentian Rise and attributed by Emery et al.* * Emery et al. (1970). to the 1929 Grand Banks earthquake. The Munson-Nygren slide may have been triggered by a large earthquake in late Pleistocene time or later. Destructional landforms associated with the slide are similar to those widely present along the lower slope off Georges Bank. ?? 1986.

Occurrence and effects of endocrine-disrupting chemicals in the St. Croix River

USGS Publications Warehouse

Elliott, Sarah M.; Lee, Kathy E.

2016-01-01

The St. Croix River is one of the last undisturbed, large floodplain rivers in the upper Mississippi River System. The Saint Croix National Scenic Riverway encompasses 255 river miles from the St. Croix Flowage and Namekagon River to the confluence of the St. Croix River with the Mississippi River at Prescott, Wisconsin. The Wild and Scenic Rivers Act of 1968 includes protection of the “outstandingly remarkable values” of the St. Croix and Namekagon rivers, which are included in the first eight designated wild and scenic rivers. The National Park Service (NPS) supports efforts to ensure these high-quality waters are not degraded by endocrine-disrupting or pharmaceutically active chemicals.

Giving Psychology Away: How George Miller's Vision Is Being Realised by Psychological Literacy

ERIC Educational Resources Information Center

Banyard, Philip; Hulme, Julie A.

2015-01-01

In George Miller's famous address to the American Psychological Association in 1969 he explored the aims and future direction of psychology. Psychology could develop as a professional elite that develops specialised knowledge that experts can hold on to or it could aim to "give psychology away" and to allow the general public access to…

Earliest report of the genus Phyricodothyris George (Brachiopoda: Reticularioidea) in North America

USGS Publications Warehouse

Carter, J.L.; Kollar, A.D.; Brezinski, D.K.

2008-01-01

Described from the Wymps Gap Member of the Mauch Chunk Formation of southwestern Pennsylvania and adjacent Maryland is a new species, Phyricodothyris lauriegrahamae, of the Upper Mississippian reticulariod brachiopod Phyricodothyris George, 1932. The Wymps Gap Limestone from which the type material was collected is middle Chesterian (late Visdan) in age. This is the first report of this genus from confirmed Mississippian rocks in North America.

Panel discussion: Marketing hardwoods at the George O. White State Forest Nursery

Treesearch

Greg Hoss

2011-01-01

The George O. White State Forest Nursery is a hardwood nursery located in a state dominated by hardwood species. Marketing and selling our hardwoods is what we do. Depending on the year and seed availability, we grow about 65 species of hardwood trees and shrubs. During the last 5 years, we have grown about 60 hardwood species per year. We also grow about six species...

Rebuilding Mount St. Helens

USGS Publications Warehouse

Schilling, Steve P.; Ramsey, David W.; Messerich, James A.; Thompson, Ren A.

2006-01-01

On May 18, 1980, Mount St. Helens, Washington exploded in a spectacular and devastating eruption that shocked the world. The eruption, one of the most powerful in the history of the United States, removed 2.7 cubic kilometers of rock from the volcano's edifice, the bulk of which had been constructed by nearly 4,000 years of lava-dome-building eruptions. In seconds, the mountain's summit elevation was lowered from 2,950 meters to 2,549 meters, leaving a north-facing, horseshoe-shaped crater over 2 kilometers wide. Following the 1980 eruption, Mount St. Helens remained active. A large lava dome began episodically extruding in the center of the volcano's empty crater. This dome-building eruption lasted until 1986 and added about 80 million cubic meters of rock to the volcano. During the two decades following the May 18, 1980 eruption, Crater Glacier formed tongues of ice around the east and west sides of the lava dome in the deeply shaded niche between the lava dome and the south crater wall. Long the most active volcano in the Cascade Range with a complex 300,000-year history, Mount St. Helens erupted again in the fall of 2004 as a new period of dome building began within the 1980 crater. Between October 2004 and February 2006, about 80 million cubic meters of dacite lava erupted immediately south of the 1980-86 lava dome. The erupting lava separated the glacier into two parts, first squeezing the east arm of the glacier against the east crater wall and then causing equally spectacular crevassing and broad uplift of the glacier's west arm. Vertical aerial photographs document dome growth and glacier deformation. These photographs enabled photogrammetric construction of a series of high-resolution digital elevation models (DEMs) showing changes from October 4, 2004 to February 9, 2006. From the DEMs, Geographic Information Systems (GIS) applications were used to estimate extruded volumes and growth rates of the new lava dome. The DEMs were also used to quantify dome

Air Pollution and ST-Segment Depression in Elderly Subjects

PubMed Central

Gold, Diane R.; Litonjua, Augusto A.; Zanobetti, Antonella; Coull, Brent A.; Schwartz, Joel; MacCallum, Gail; Verrier, Richard L.; Nearing, Bruce D.; Canner, Marina J.; Suh, Helen; Stone, Peter H.

2005-01-01

Increased levels of daily ambient particle pollution have been associated with increased risk of cardiovascular morbidity. Black carbon (BC) is a measure of the traffic-related component of particles. We investigated associations between ambient pollution and ST-segment levels in a repeated-measures study including 269 observations on 24 active Boston residents 61–88 years of age, each observed up to 12 times from June through September 1999. The protocol involved continuous Holter electrocardiogram monitoring including 5 min of rest, 5 min of standing, 5 min of exercise outdoors, 5 min of recovery, and 20 cycles of paced breathing. Pollution-associated ST-depression was estimated for a 10th- to 90th-percentile change in BC. We calculated the average ST-segment level, referenced to the P-R isoelectric values, for each portion of the protocol. The mean BC level in the previous 12 hr, and the BC level 5 hr before testing, predicted ST-segment depression in most portions of the protocol, but the effect was strongest in the postexercise periods. During post-exercise rest, an elevated BC level was associated with −0.1 mm ST-segment depression (p = 0.02 for 12-hr mean BC; p = 0.001 for 5-hr BC) in continuous models. Elevated BC also predicted increased risk of ST-segment depression ≥0.5 mm among those with at least one episode of that level of ST-segment depression. Carbon monoxide was not a confounder of this association. ST-segment depression, possibly representing myocardial ischemia or inflammation, is associated with increased exposure to particles whose predominant source is traffic. PMID:16002377

The Year of Critical Thinking at Prince George's Community College: An Integrated Professional Development Program

ERIC Educational Resources Information Center

Peirce, William P.

2005-01-01

This chapter describes the context, development, and fall 2004 implementation of the Year of Critical Thinking at Prince George's Community College, an effort to engage all full-time and adjunct faculty in teaching critical thinking in their classes.

Victualing Victory: Logistics from Lake George to KHE SANH, 1755-1968

DTIC Science & Technology

2016-06-01

in 1968. As the technology changed through Mumford’s eras from the age of wood, wind , and sail at Lake George, to the nuclear weapon and the...overland to Fontenoy. Transportation on land, in an age of wood, wind , and sail, was cumbersome, with rough-hewn wagons carrying cargo on rutted...era, the Eotechnic, described the period from 1000-1750. It was the “dawn age of modern” technology.6 The power of water and wind were the motive

75 FR 7286 - Rappahannock River Valley National Wildlife Refuge, Caroline, Essex, King George, Lancaster...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-18

... DEPARTMENT OF THE INTERIOR Fish and Wildlife Service [FWS-R5-R-2009-N203; BAC-4311-K9-S3] Rappahannock River Valley National Wildlife Refuge, Caroline, Essex, King George, Lancaster, Middlesex, Richmond, and Westmoreland Counties, VA AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of...

Kindergarten to 1st Grade: Classroom Characteristics and the Stability and Change of Children's Classroom Experiences

ERIC Educational Resources Information Center

La Paro, Karen M.; Rimm-Kaufman, Sara E.; Pianta, Robert C.

2006-01-01

This study examines the classroom experiences of 192 children followed longitudinally from kindergarten to 1st grade. Time-sampled observations of children were conducted to compare learning formats, teaching activities, and children's engagement in activities between kindergarten and 1st grade. Classroom observations also were conducted to…

Nine year active layer thermal monitoring at Fildes Peninsula, King George Island, Maritime Antarctica

NASA Astrophysics Data System (ADS)

Michel, Roberto; Andrade, André; Simas, Felipe; Silva, Tássio; Loureiro, Diego; Schaefer, Carlos

2017-04-01

Most global circulation models predict enhanced rates of climate change, particularly temperature increase, at higher latitudes witch are currently faced with rapid rates of regional climate change (Convey 2006, Vaughan et al. 2003, Quayle et al. 2002), Antarctic ecosystems are expected to show particular sensitivity and rapid responses (Freckman and Virginia 1997, Quayle et al. 2002, 2003). The active layer and permafrost are important components of the cryosphere due to their role in energy flux regulation and sensitivity to climate change (Kane et al., 2001; Smith and Brown, 2009). Compared with other regions of the globe, our understanding of Antarctic permafrost is poor, especially in relation to its thermal state and evolution, (Bockheim, 1995, Bockheim et al., 2008). The active layer monitoring site was installed in the summer of 2008, and consists of thermistors (accuracy ± 0.2 °C) arranged in a vertical array (Turbic Eutric Cryosol 60 m asl, 10.5 cm, 32.5 cm, 67.5 cm and 83.5 cm). All probes were connected to a Campbell Scientific CR 1000 data logger recording data at hourly intervals from March 1st 2008 until November 30th 2012. We calculated the thawing days (TD), freezing days (FD); thawing degree days (TDD) and freezing degree days (FDD); all according to Guglielmin et al. (2008). The active lawyer thickness was calculated as the 0 °C depth by extrapolating the thermal gradient from the two deepest temperature measurements (Guglielmin, 2006). The temperature at 10.5 cm reaches a maximum daily average (5.6 °C) in late January 2015, reaching a minimum (-9.6 °C) in in early August 2011, at 83.5 cm maximum daily average (0.6 °C) was reached in mid March 2009 and minimum (-5.5 °C) also in early August 2011. The years of 2008, 2009 and 2011 recorded thaw days at the bottom of the profile (62 and 49 in 2009 and 2011), and logged the highest soil moisture contents of the time series (62%, 59% and 63%). Seasonal variability of the active layer shows

Russia: St. Petersburg

Atmospheric Science Data Center

2013-04-17

article title:  St. Petersburg, Russia     View Larger Image ... The city in the south eastern portion of the image is Russia's St. Petersburg, which is the most northerly large city in the world at ...

Genotypic and phenotypic profiles of Escherichia coli isolates belonging to clinical sequence type 131 (ST131), clinical non-ST131, and fecal non-ST131 lineages from India.

PubMed

Hussain, Arif; Ranjan, Amit; Nandanwar, Nishant; Babbar, Anshu; Jadhav, Savita; Ahmed, Niyaz

2014-12-01

In view of the epidemiological success of CTX-M-15-producing lineages of Escherichia coli and particularly of sequence type 131 (ST131), it is of significant interest to explore its prevalence in countries such as India and to determine if antibiotic resistance, virulence, metabolic potential, and/or the genetic architecture of the ST131 isolates differ from those of non-ST131 isolates. A collection of 126 E. coli isolates comprising 43 ST131 E. coli, 40 non-ST131 E. coli, and 43 fecal E. coli isolates collected from a tertiary care hospital in India was analyzed. These isolates were subjected to enterobacterial repetitive intergenic consensus (ERIC)-based fingerprinting, O typing, phylogenetic grouping, antibiotic sensitivity testing, and virulence and antimicrobial resistance gene (VAG) detection. Representative isolates from this collection were also analyzed by multilocus sequence typing (MLST), conjugation, metabolic profiling, biofilm production assay, and zebra fish lethality assay. All of the 43 ST131 E. coli isolates were exclusively associated with phylogenetic group B2 (100%), while most of the clinical non-ST131 and stool non-ST131 E. coli isolates were affiliated with the B2 (38%) and A (58%) phylogenetic groups, respectively. Significantly greater proportions of ST131 isolates (58%) than non-ST131 isolates (clinical and stool E. coli isolates, 5% each) were technically identified to be extraintestinal pathogenic E. coli (ExPEC). The clinical ST131, clinical non-ST131, and stool non-ST131 E. coli isolates exhibited high rates of multidrug resistance (95%, 91%, and 91%, respectively), extended-spectrum-β-lactamase (ESBL) production (86%, 83%, and 91%, respectively), and metallo-β-lactamase (MBL) production (28%, 33%, and 0%, respectively). CTX-M-15 was strongly linked with ESBL production in ST131 isolates (93%), whereas CTX-M-15 plus TEM were present in clinical and stool non-ST131 E. coli isolates. Using MLST, we confirmed the presence of two NDM-1

Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258: a systematic review and meta-analysis

PubMed Central

Dautzenberg, M J D; Haverkate, M R; Bonten, M J M; Bootsma, M C J

2016-01-01

Objectives Observational studies have suggested that Escherichia coli sequence type (ST) 131 and Klebsiella pneumoniae ST258 have hyperendemic properties. This would be obvious from continuously high incidence and/or prevalence of carriage or infection with these bacteria in specific patient populations. Hyperendemicity could result from increased transmissibility, longer duration of infectiousness, and/or higher pathogenic potential as compared with other lineages of the same species. The aim of our research is to quantitatively estimate these critical parameters for E. coli ST131 and K. pneumoniae ST258, in order to investigate whether E. coli ST131 and K. pneumoniae ST258 are truly hyperendemic clones. Primary outcome measures A systematic literature search was performed to assess the evidence of transmissibility, duration of infectiousness, and pathogenicity for E. coli ST131 and K. pneumoniae ST258. Meta-regression was performed to quantify these characteristics. Results The systematic literature search yielded 639 articles, of which 19 data sources provided information on transmissibility (E. coli ST131 n=9; K. pneumoniae ST258 n=10)), 2 on duration of infectiousness (E. coli ST131 n=2), and 324 on pathogenicity (E. coli ST131 n=285; K. pneumoniae ST258 n=39). Available data on duration of carriage and on transmissibility were insufficient for quantitative assessment. In multivariable meta-regression E. coli isolates causing infection were associated with ST131, compared to isolates only causing colonisation, suggesting that E. coli ST131 can be considered more pathogenic than non-ST131 isolates. Date of isolation, location and resistance mechanism also influenced the prevalence of ST131. E. coli ST131 was 3.2 (95% CI 2.0 to 5.0) times more pathogenic than non-ST131. For K. pneumoniae ST258 there were not enough data for meta-regression assessing the influence of colonisation versus infection on ST258 prevalence. Conclusions With the currently available data

Georges Lemaître: Science and Religion

NASA Astrophysics Data System (ADS)

Coyne, George V.

In order to appreciate the contribution which Georges Lemaître made to the relationship between religion and science it is necessary to understand how the Catholic Church, of which he was a priest, passed in the course of three centuries, from a position of conflict with the sciences to one of compatible openness and dialogue. In doing this I hope to show that the natural sciences have played a significant role in helping to establish the kind of dialogue that is absolutely necessary for the enrichment of the multifaceted aspects of human culture. I will speak of the following four periods of history: (l) the rise of modern atheism in the seventeenth and eighteenth centuries; (2) anticlericalism in Europe in the nineteenth century; (3) the awakening within the Catholic Church to modern science in the first six decades of the twentieth century; (4) the Church's view today.

33 CFR 165.762 - Security Zone; St. Thomas, U.S. Virgin Islands.

Code of Federal Regulations, 2014 CFR

2014-07-01

....762 Security Zone; St. Thomas, U.S. Virgin Islands. (a) Location. Moving and fixed security zones are established 50 yards around all cruise ships entering, departing, moored or anchored in the Port of St. Thomas, U.S. Virgin Islands. The security zone for a cruise ship entering port is activated when the vessel...

33 CFR 165.762 - Security Zone; St. Thomas, U.S. Virgin Islands.

Code of Federal Regulations, 2012 CFR

2012-07-01

....762 Security Zone; St. Thomas, U.S. Virgin Islands. (a) Location. Moving and fixed security zones are established 50 yards around all cruise ships entering, departing, moored or anchored in the Port of St. Thomas, U.S. Virgin Islands. The security zone for a cruise ship entering port is activated when the vessel...

33 CFR 165.762 - Security Zone; St. Thomas, U.S. Virgin Islands.

Code of Federal Regulations, 2011 CFR

2011-07-01

....762 Security Zone; St. Thomas, U.S. Virgin Islands. (a) Location. Moving and fixed security zones are established 50 yards around all cruise ships entering, departing, moored or anchored in the Port of St. Thomas, U.S. Virgin Islands. The security zone for a cruise ship entering port is activated when the vessel...

33 CFR 165.762 - Security Zone; St. Thomas, U.S. Virgin Islands.

Code of Federal Regulations, 2013 CFR

2013-07-01

....762 Security Zone; St. Thomas, U.S. Virgin Islands. (a) Location. Moving and fixed security zones are established 50 yards around all cruise ships entering, departing, moored or anchored in the Port of St. Thomas, U.S. Virgin Islands. The security zone for a cruise ship entering port is activated when the vessel...

77 FR 26659 - Political Activity-Federal Employees Residing in Designated Localities

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-07

... partial exemption from the political activity restrictions in the Hatch Act, and to add King George County... George County meets the criteria in the Hatch Act and OPM regulations for a partial exemption to issue... INFORMATION: The Hatch Act, at 5 U.S.C. 7323(a)(2) and (3), prohibits Federal employees from becoming...

The life of concepts: Georges Canguilhem and the history of science.

PubMed

Schmidgen, Henning

2014-01-01

Twelve years after his famous Essay on Some Problems Concerning the Normal and the Pathological (1943), the philosopher Georges Canguilhem (1904-1995) published a book-length study on the history of a single biological concept. Within France, his Formation of the Reflex Concept in the Seventeenth and Eighteenth Centuries (1955) contributed significantly to defining the "French style" of writing on the history of science. Outside of France, the book passed largely unnoticed. This paper re-reads Canguilhem's study of the reflex concept with respect to its historiographical and epistemological implications. Canguilhem defines concepts as complex and dynamic entities combining terms, definitions, and phenomena. As a consequence, the historiography of science becomes a rather complex task. It has to take into account textual and contextual aspects that develop independently of individual authors. In addition, Canguilhem stresses the connection between conceptual activities and other functions of organic individuals in their respective environments. As a result, biological concepts become tied to a biology of conceptual thinking, analogical reasoning, and technological practice. The paper argues that this seemingly circular structure is a major feature in Canguilhem's philosophical approach to the history of the biological sciences.

Isolation and characterization of StERF transcription factor genes from potato (Solanum tuberosum L.).

PubMed

Wang, Zemin; Zhang, Ning; Zhou, Xiangyan; Fan, Qiang; Si, Huaijun; Wang, Di

2015-04-01

Ethylene response factor (ERF) is a major subfamily of the AP2/ERF family and plays significant roles in the regulation of abiotic- and biotic-stress responses. ERF proteins can interact with the GCC-box cis-element and then initiate a transcriptional cascade activating downstream ethylene response and enhancing plant stress tolerance. In this research, we cloned five StERF genes from potato (Solanum tuberosum L.). The expressional analysis of StERF genes revealed that they showed tissue- or organ-specific expression patterns and the expression levels in leaf, stem, root, flower, and tuber were different. The assays of quantitative real-time polymerase chain reaction (qRT-PCR) and the reverse transcription-PCR (RT-PCR) showed that the expression of five StERF genes was regulated by ethephon, methyl jasmonate (MeJA), salt and drought stress. The result from the yeast one-hybrid experiment showed that five StERFs had trans-activation activity and could specifically bind to the GCC-box cis-elements. The StERFs responded to abiotic factors and hormones suggested that they possibly had diverse roles in stress and hormone regulation of potato. Copyright © 2015 Académie des sciences. Published by Elsevier SAS. All rights reserved.

Environmental statement for the George C. Marshall Space Flight Center and Mississippi Test Facility

NASA Technical Reports Server (NTRS)

1972-01-01

The environmental impact was investigated for the George C. Marshall Space Flight Center, and the Mississippi Test Facility. The installations are described, and the missions, environmental impact, and commitment of resources are discussed. It is concluded that there are negligible adverse environmental effects related to these two installations.

A Pilot Project in Augmentative Distance Learning... George Mason University Graduate Course in Biochemistry.

ERIC Educational Resources Information Center

Willett, James D.; Keefe, David D.

This paper describes the use of distance learning capabilities to augment and amplify the learning opportunities for part-time graduate students at George Mason University. The students in the biochemistry course described meet periodically on campus for brief interactions with the instructor and peer classmates. Between these synchronous…

The Relevance of Hans-Georg Gadamer's Concept of Tradition to the Philosophy of Education

ERIC Educational Resources Information Center

Leiviskä, Anniina

2015-01-01

In this article, Anniina Leiviskä argues that the educational relevance of Hans-Georg Gadamer's concept of tradition has remained unacknowledged because of the conservatism that has been associated with Gadamer's hermeneutics, particularly his notion of tradition. Therefore, Leiviskä seeks to reveal the reflective, nonconservative nature of…

Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation.

PubMed

Li, Chuwen; Chen, Tongkai; Zhou, Hefeng; Zhang, Chao; Feng, Yu; Tang, Fan; Hoi, Maggie Pui-Man; He, Chengwei; Zheng, Ying; Lee, Simon Ming-Yuen

2018-06-28

In the present study, we investigated whether schisantherin A (StA) had anti-inflammatory effects under neuroinflammatory conditions. The effects of StA and its underlying mechanisms were examined in lipopolysaccharide (LPS)-activated BV-2 microglial cells by ELISA, qPCR, EMSA, Western blot, and IHC. Firstly, we found that StA inhibited the inflammatory response in LPS-activated BV-2 microglia. Secondly, we found that StA suppressed LPS-induced activation of NF-κB via interfering with degradation of IκB and phosphorylation of IκB, IKK, PI3K/Akt, JNK, and p38 MAPK. Thirdly, StA conferred indirect antioxidative effects via quenching ROS and promoted expression of antioxidant enzymes, including HO-1 and NQO-1, via stimulating activation of Nrf2 pathways. Finally, we demonstrated that anti-neuroinflammatory actions of StA were dependent on ERK phosphorylation-mediated Nrf2 activation. StA induced ERK phosphorylation-mediated Nrf2 activation, which contributed to its anti-inflammation and anti-oxidation. The anti-neuroinflammatory and anti-oxidative effects of StA may show preventive therapeutic potential for various neuroinflammatory disorders. © 2018 The Author(s). Published by S. Karger AG, Basel.

33 CFR 100.915 - St. Clair River Classic Offshore Race, St. Clair, MI.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false St. Clair River Classic Offshore Race, St. Clair, MI. 100.915 Section 100.915 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.915 St. Clair River...

33 CFR 100.915 - St. Clair River Classic Offshore Race, St. Clair, MI.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false St. Clair River Classic Offshore Race, St. Clair, MI. 100.915 Section 100.915 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Classic Offshore Race, St. Clair, MI. (a) Regulated Area. A regulated area is established to include all...

33 CFR 100.915 - St. Clair River Classic Offshore Race, St. Clair, MI.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false St. Clair River Classic Offshore Race, St. Clair, MI. 100.915 Section 100.915 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Classic Offshore Race, St. Clair, MI. (a) Regulated Area. A regulated area is established to include all...

33 CFR 100.915 - St. Clair River Classic Offshore Race, St. Clair, MI.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false St. Clair River Classic Offshore Race, St. Clair, MI. 100.915 Section 100.915 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Classic Offshore Race, St. Clair, MI. (a) Regulated Area. A regulated area is established to include all...

33 CFR 100.915 - St. Clair River Classic Offshore Race, St. Clair, MI.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false St. Clair River Classic Offshore Race, St. Clair, MI. 100.915 Section 100.915 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Classic Offshore Race, St. Clair, MI. (a) Regulated Area. A regulated area is established to include all...

36 CFR 1253.3 - Presidential Libraries.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Lyndon Baines Johnson Library and Museum is located at 2313 Red River St., Austin, TX 78705-5702. The.... Hours for the Presidential libraries' research rooms are posted at http://www.archives.gov. [email protected] (k) George Bush Library is located at 1000 George Bush Drive West, College Station, TX...

36 CFR 1253.3 - Presidential Libraries.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) Lyndon Baines Johnson Library and Museum is located at 2313 Red River St., Austin, TX 78705-5702. The.... Hours for the Presidential libraries' research rooms are posted at http://www.archives.gov. [email protected] (k) George Bush Library is located at 1000 George Bush Drive West, College Station, TX...

36 CFR § 1253.3 - Presidential Libraries.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) Lyndon Baines Johnson Library and Museum is located at 2313 Red River St., Austin, TX 78705-5702. The... Libraries. Hours for the Presidential libraries' research rooms are posted at http://www.archives.gov. [email protected] (k) George Bush Library is located at 1000 George Bush Drive West, College Station, TX...

36 CFR 1253.3 - Presidential Libraries.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) Lyndon Baines Johnson Library and Museum is located at 2313 Red River St., Austin, TX 78705-5702. The.... Hours for the Presidential libraries' research rooms are posted at http://www.archives.gov. [email protected] (k) George Bush Library is located at 1000 George Bush Drive West, College Station, TX...

77 FR 8811 - Takes of Marine Mammals Incidental to Specified Activities; St. George Reef Light Station...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

... provide the most accurate means of documenting species composition, age and sex class of pinnipeds using...; Fate of the animal(s); and Photographs or video footage of the animal(s) (if equipment is available... discovery. The SGRLPS will provide photographs or video footage (if available) or other documentation of the...

75 FR 4774 - Takes of Marine Mammals Incidental to Specified Activities; St. George Reef Light Station...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-29

... two-bladed main and tail rotors which are fitted with noise-attenuating blade tip caps that would... disturbances caused by the helicopters rotors and engine. It is likely that the initial helicopter approach to... relatively quiet rotors, and behavioral habituation on the part [[Page 4776

78 FR 1838 - Takes of Marine Mammals Incidental to Specified Activities; St. George Reef Light Station...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-09

... Sunday work window period. Although some of these flights would be conducted solely for the... at least once or up to two times per year within the proposed work window. Scheduled light... emergency repair event, the Society proposes to conduct a maximum of four flights (two arrivals and two...

Bart's familiar quotations: the enduring biological wisdom of George A. Bartholomew.

PubMed

Huey, Raymond B; Bennett, Albert F

2008-01-01

George A. Bartholomew was one of the most influential organismal biologists of the twentieth century. His insights and research were fundamental to the establishment and growth of physiological ecology and evolutionary physiology. In the process of fostering that area of science, he created a body of literature that is striking in the clarity of its thought and presentation. Here we present some of his most insightful and important quotations, group them thematically, and comment on their original context and their continuing relevance.

Potential utilization of the NASA/George C. Marshall Space Flight Center in earthquake engineering research

NASA Technical Reports Server (NTRS)

Scholl, R. E. (Editor)

1979-01-01

Earthquake engineering research capabilities of the National Aeronautics and Space Administration (NASA) facilities at George C. Marshall Space Flight Center (MSFC), Alabama, were evaluated. The results indicate that the NASA/MSFC facilities and supporting capabilities offer unique opportunities for conducting earthquake engineering research. Specific features that are particularly attractive for large scale static and dynamic testing of natural and man-made structures include the following: large physical dimensions of buildings and test bays; high loading capacity; wide range and large number of test equipment and instrumentation devices; multichannel data acquisition and processing systems; technical expertise for conducting large-scale static and dynamic testing; sophisticated techniques for systems dynamics analysis, simulation, and control; and capability for managing large-size and technologically complex programs. Potential uses of the facilities for near and long term test programs to supplement current earthquake research activities are suggested.

Geophysical observations on northern part of Georges Bank and adjacent basins of Gulf of Maine

USGS Publications Warehouse

Oldale, R.N.; Hathaway, J.C.; Dillon, William P.; Hendricks, J.D.; Robb, James M.

1974-01-01

Continuous-seismic-reflection and magnetic-intensity profiles provide data for inferences about the geology of the northern part of Georges Bank and the basins of the Gulf of Maine adjacent to the bank.Basement is inferred to be mostly sedimentary and volcanic rocks of Paleozoic age that were metamorphosed and intruded locally by felsic and mafic plutons near the end of the Paleozoic Era. During Late Triassic time, large fault basins formed within the Gulf of Maine and probably beneath Georges Bank. The fault basins and a possible major northeast-trending fault zone beneath the northern part of the bank probably formed as a result of the opening Atlantic during the Mesozoic. Nonmarine sediments, associated with mafic flows and intrusive rocks, were deposited in the fault basins as they formed. The upper surface of the Triassic and pre-Triassic rocks that comprise basement is an unconformity that makes up much of the bottom of the Gulf of Maine. Depth to the basement surface beneath the gulf differ greatly because of fluvial erosion in Tertiary time and glacial erosion in Pleistocene time. Beneath the northern part of Georges Bank the basement surface is smoother and slopes southward. Prominent valleys, cut before Late Cretaceous time, are present beneath this part of the bank.Cretaceous, Tertiary, and possibly Jurassic times were characterized by episodes of coastal-plain deposition and fluvial erosion. During this time a very thick wedge of sediment, mostly of Jurassic(?) and Cretaceous ages, was deposited on the shelf. Major periods of erosion took place at the close of the Cretaceous and during the Pliocene. Fluvial erosion during the Pliocene removed much of the coastal-plain sedimentary wedge and formed the Gulf of Maine.Pleistocene glaciers eroded all but a few remnants of the coastal-plain sediments within the gulf and deposited a thick section of drift against the north slope of Georges Bank and a thin veneer of outwash on the bank. Marine sediments were

St2-80: a new FISH marker for St genome and genome analysis in Triticeae.

PubMed

Wang, Long; Shi, Qinghua; Su, Handong; Wang, Yi; Sha, Lina; Fan, Xing; Kang, Houyang; Zhang, Haiqin; Zhou, Yonghong

2017-07-01

The St genome is one of the most fundamental genomes in Triticeae. Repetitive sequences are widely used to distinguish different genomes or species. The primary objectives of this study were to (i) screen a new sequence that could easily distinguish the chromosome of the St genome from those of other genomes by fluorescence in situ hybridization (FISH) and (ii) investigate the genome constitution of some species that remain uncertain and controversial. We used degenerated oligonucleotide primer PCR (Dop-PCR), Dot-blot, and FISH to screen for a new marker of the St genome and to test the efficiency of this marker in the detection of the St chromosome at different ploidy levels. Signals produced by a new FISH marker (denoted St 2 -80) were present on the entire arm of chromosomes of the St genome, except in the centromeric region. On the contrary, St 2 -80 signals were present in the terminal region of chromosomes of the E, H, P, and Y genomes. No signal was detected in the A and B genomes, and only weak signals were detected in the terminal region of chromosomes of the D genome. St 2 -80 signals were obvious and stable in chromosomes of different genomes, whether diploid or polyploid. Therefore, St 2 -80 is a potential and useful FISH marker that can be used to distinguish the St genome from those of other genomes in Triticeae.

The plasma levels of soluble ST2 as a marker of gut mucosal damage in early HIV infection

PubMed Central

Mehraj, Vikram; Jenabian, Mohammad-Ali; Ponte, Rosalie; Lebouché, Bertrand; Costiniuk, Cecilia; Thomas, Réjean; Baril, Jean-Guy; LeBlanc, Roger; Cox, Joseph; Tremblay, Cécile; Routy, Jean-Pierre

2016-01-01

Objective: Following tissue barrier breaches, interleukin-33 (IL-33) is released as an ‘alarmin’ to induce inflammation. Soluble suppression of tumorigenicity 2 (sST2), as an IL-33 decoy receptor, contributes to limit inflammation. We assessed the relationship between the IL-33/ST2 axis and markers of gut mucosal damage in patients with early (EHI) and chronic HIV infection (CHI) and elite controllers. Design: Analyses on patients with EHI and CHI were conducted to determine IL-33/sST2 changes over time. Methods: IL-33 and sST2 levels were measured in plasma. Correlations between sST2 levels and plasma viral load, CD4+ and CD8+ T-cell counts, expression of T-cell activation/exhaustion markers, gut mucosal damage, microbial translocation and inflammation markers, as well as kynurenine/tryptophan ratio were assessed. Results: Plasma sST2 levels were elevated in EHI compared with untreated CHI and uninfected controls, whereas IL-33 levels were comparable in all groups. In EHI, sST2 levels were positively correlated with the CD8+ T-cell count and the percentage of T cells expressing activation and exhaustion markers, but not with viral load or CD4+ T-cell count. Plasma sST2 levels also correlated with plasma levels of gut mucosal damage, microbial translocation and kynurenine/tryptophan ratio and for some markers of inflammation. Prospective analyses showed that early antiretroviral therapy had no impact on sST2 levels, whereas longer treatment duration initiated during CHI normalized sST2. Conclusion: As sST2 levels were elevated in EHI and were correlated with CD8+ T-cell count, immune activation, and microbial translocation, sST2 may serve as a marker of disease progression, gut damage and may directly contribute to HIV pathogenesis. PMID:27045377

Coral bleaching, hurricane damage, and benthic cover on coral reefs in St. John, U.S. Virgin Islands: A comparison of surveys with the chain transect method and videography

USGS Publications Warehouse

Rogers, C.S.; Miller, J.

2001-01-01

The linear chain transect method and videography were used to quantify the percent cover by corals, macroalgae, gorgonians, other living organisms, and substrate along permanent transects on two fringing reefs off St. John. Both methods were used simultaneously on Lameshur reef in November 1998, and on Newfound reef in March and October 1998. Hurricane Georges passed over St. John in September 1998, and a severe coral bleaching episode began the same month. Both methods gave remarkably similar values for coral cover, while the video method gave consistently higher values for gorgonians and macroalgae. The most dramatic difference was in the quantification of bleaching. At Newfound, the chain method indicated 13.4% (SD = 14.1) of the coral tissues were bleached and the video method, 43.4% (SD = 13.0). Corresponding values at Lameshur were 18.1% (SD = 22.3) and 46.5% (SD = 13.3). Although hurricane damage was conspicuous at Newfound reef, neither method showed significant changes in coral cover or other categories as a result of the storm.

George W. Wingate High School Multilingual Survival Skills Program, 1985-1986. OEA Evaluation Report.

ERIC Educational Resources Information Center

New York City Board of Education, Brooklyn. Office of Educational Assessment.

The Multilingual Survival Skills Program, in its final year of a three-year funding cycle, provided instructional and support services to 350 Haitian and Hispanic students of limited English proficiency (LEP) at George Wingate High School (Brooklyn, New York). The program emphasized the acquisition of English language skills, using students'…

Georg Rasch and Benjamin Wright's Struggle with the Unidimensional Polytomous Model with Sufficient Statistics

ERIC Educational Resources Information Center

Andrich, David

2016-01-01

This article reproduces correspondence between Georg Rasch of The University of Copenhagen and Benjamin Wright of The University of Chicago in the period from January 1966 to July 1967. This correspondence reveals their struggle to operationalize a unidimensional measurement model with sufficient statistics for responses in a set of ordered…

The fishes of George Washington Carver National Monument, Missouri, 2003

USGS Publications Warehouse

Justus, B.G.; Petersen, James C.

2005-01-01

Fish were collected at six sites at George Washington Carver National Monument by seining and electrofishing during a base-flow period on July 17-18, 2003. Approximately 700 fish were collected and identified at the six sampling sites. Those individuals represented 17 species (and 1 hybrid) and 13 genera. The number of species collected at the five stream sites ranged from 9 to 12; a hybrid sunfish and 4 species were collected from a pond. Fish collected at stream sites were typical of small headwater streams and no species collected in this study are federally-listed threatened or endangered species. The three most common species were the southern redbelly dace, central stoneroller, and green sunfish. Some differences existed between the assemblages (groups of species) collected in 2003 and in the previous inventories. Four of the 17 fish species collected in this inventory previously had not been collected at the monument. However, 11 species collected in one or more of the previous inventories were not collected in this effort. There is no indication that a change in environmental conditions is responsible for the absence of these species; more likely reasons are seasonal variability, extirpation, low population density, and misidentification. Four species collected at George Washington Carver National Monument may be of special interest to National Park Service managers and others. The cardinal shiner and stippled darter are endemic to the Ozark Plateaus. The Arkansas darter is considered a species of conservation concern by the State of Missouri. The grass carp is an introduced species.

78 FR 16780 - Special Local Regulation; 2013 International Rolex Regatta; St. Thomas Harbor; St. Thomas, U.S...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-19

... 1625-AA08 Special Local Regulation; 2013 International Rolex Regatta; St. Thomas Harbor; St. Thomas, U... is establishing special local regulations on the waters of St. Thomas Harbor in St. Thomas, U. S... changes to the regulation as originally proposed. On March 22, 2013, through March 24, 2013, the St...

Twisting and Writhing with George Ellery Hale

NASA Astrophysics Data System (ADS)

Canfield, Richard C.

2013-06-01

Early in his productive career in astronomy, George Ellery Hale developed innovative solar instrumentation that allowed him to make narrow-band images. Among the solar phenomena he discovered were sunspot vortices, which he attributed to storms akin to cyclones in our own atmosphere. Using the concept of magnetic helicity, physicists and mathematicians describe the topology of magnetic fields, including twisting and writhing. Our contemporary understanding of Hale's vortices as a consequence of large-scale twist in sunspot magnetic fields hinges on a key property of helicity: conservation. I will describe the critical role that this property plays, when applied to twist and writhe, in a fundamental aspect of global solar magnetism: the hemispheric and solar cycle dependences of active region electric currents with respect to magnetic fields. With the advent of unbroken sequences of high-resolution magnetic images, such as those presently available from the Helioseismic and Magnetic Imager on Solar Dynamics Observatory, the flux of magnetic helicity through the photosphere can be observed quantitatively. As magnetic flux tubes buoy up through the convection zone, buffeted and shredded by turbulence, they break up into fragments by repeated random bifurcation. We track these rising flux fragments in the photosphere, and calculate the flux of energy and magnetic helicity there. Using a quantitative model of coronal currents, we also track connections between these fragments to calculate the energy and magnetic helicity stored at topological interfaces that are in some ways analogous to the storage of stress at faults in the Earth's crust. Comparison of these values to solar flares and interplanetary coronal mass ejections implies that this is the primary storage mechanism for energy and magnetic helicity released in those phenomena, and suggests a useful tool for quantitative prediction of geomagnetic storms.

Hypoxia reduces testosterone synthesis in mouse Leydig cells by inhibiting NRF1-activated StAR expression

PubMed Central

Zou, Zhiran; Wang, Dan; Lu, Yapeng; Dong, Zhangji; Zhu, Li

2017-01-01

Male fertility disorders play a key role in half of all infertility cases. Reduction in testosterone induced by hypoxia might cause diseases in reproductive system and other organs. Hypoxic exposure caused a significant decrease of NRF1. Software analysis reported that the promoter region of steroidogenic acute regulatory protein (StAR) contained NRF1 binding sites, indicating NRF1 promoted testicular steroidogenesis. The purpose of this study is to determine NRF1 is involved in testosterone synthesis; and under hypoxia, the decrease of testosterone synthesis is caused by lower expression of NRF1. We designed both in vivo and in vitro experiments. Under hypoxia, the expressions of NRF1 in Leydig cells and testosterone level were significantly decreased both in vivo and in vitro. Overexpression and interference NRF1 could induced StAR and testosterone increased and decreased respectively. ChIP results confirmed the binding of NRF1 to StAR promoter region. In conclusion, decline of NRF1 expression downregulated the level of StAR, which ultimately resulted in a reduction in testosterone synthesis. PMID:28146428

Ice-front change and iceberg behaviour along Oates and George V Coasts, Antarctica, 1912-96

USGS Publications Warehouse

Frezzotti, M.; Cimbelli, A.; Ferrigno, J.G.

1998-01-01

Ice-front change may well be a sensitive indicator of regional climate change. We have studied the western Oates Coast from Cape Kinsey (158??50'E, 69??19'S) to Cape Hudson (153??45'E, 68??20'S) and the entire George V Coast, from Cape Hudson to Point Alden (142??02'E, 66??48'S). The glaciers here drain part of the Dome Charlie and Talos Dome areas (640 000 km2). A comparison between various documents, dated several years apart, has allowed an estimate of the surficial ice discharge, the ice-front fluctuation and the iceberg-calving flux during the last 50 years. The ice-front discharge of the studied coast has been estimated at about 90??12 km3 a-1 in 1989-91, 8.5 km3 a-1 for western Oates Coast and 82 km3 a-1 for George V Coast. From 1962-63 to 1973-74 the floating glaciers underwent a net reduction that continued from 1973-74 to 1989-91. On the other hand, from 1989-91 to 1996 the area of floating glaciers increased. Ninnis Glacier Tongue and the western part of Cook Ice Shelf underwent a significant retreat after 1980 and 1947, respectively. Satellite-image analysis of large icebergs has provided information about ice-ocean interaction and the existence of an 'iceberg trap' along George V Coast. A first estimate of the mass balance of the drainage basin of Mertz and Ninnis Glaciers shows a value close to zero or slightly negative.

76 FR 44531 - Safety Zone; Fourth Annual Chillounge Night St. Petersburg Fireworks Display, Tampa Bay, St...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-26

...-AA00 Safety Zone; Fourth Annual Chillounge Night St. Petersburg Fireworks Display, Tampa Bay, St... proposes to establish a temporary safety zone on the waters of Tampa Bay in St. Petersburg, Florida during the Fourth Annual Chillounge Night St. Petersburg Fireworks Display on Saturday, November 19, 2011...

76 FR 68098 - Safety Zone; Fourth Annual Chillounge Night St. Petersburg Fireworks Display, Tampa Bay, St...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-03

...-AA00 Safety Zone; Fourth Annual Chillounge Night St. Petersburg Fireworks Display, Tampa Bay, St... Guard is establishing a temporary safety zone on the waters of Tampa Bay in St. Petersburg, Florida during the Fourth Annual Chillounge Night St. Petersburg Fireworks Display on Saturday, November 19, 2011...

78 FR 7663 - SLR; 2013 International Rolex Regatta; St. Thomas Harbor; St. Thomas, U.S. Virgin Islands

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-04

... 1625-AA08 SLR; 2013 International Rolex Regatta; St. Thomas Harbor; St. Thomas, U.S. Virgin Islands... special local regulations on the waters of St. Thomas Harbor in St. Thomas, U. S. Virgin Islands during... through March 24, 2013, the St. Thomas Yacht Club is sponsoring the 2013 Rolex Regatta, a series of sail...

Map showing landslide susceptibility in Prince Georges County, Maryland

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pomeroy, J.S.

1989-01-01

Prince Georges County was identified during a statewide investigation of landslide susceptibility (MF-2048) as the county with the most serious slope-stability problems. This map uses a ranking system ranging from 1 (nil to very low susceptibility) to 4 (moderate to severe susceptibility). Geologic factors and precipitation are major elements in the initiation of landslides in the county. The Potomac Group and the Marlboro Clay are the most slideprone units. This map should enable users to make a rapid, generalized evaluation of the potential for mass movement. Planners, engineers, soil scientists, geologist, university faculty, and elected officials should find it usefulmore » in the assessment of slope hazards for county-wide analyses.« less

Family Life and Human Development (Sex Education): The Prince George's County Public Schools Experience.

ERIC Educational Resources Information Center

Schaffer, Michael J.

1981-01-01

The Prince George's County schools' sex education program for grades K-12 was developed and implemented in the late 1960s and has three focus areas: family life and interpersonal relationships; the physiological and personality changes during puberty; and advanced physiology and psychology of human sexual behavior. The program augments what the…

Surficial geology and shaded seafloor relief of Georges Bank, Fundian Channel and Northeast Channel, Gulf of Maine

USGS Publications Warehouse

Todd, B.J.; Valentine, Page C.

2015-01-01

Georges Bank is a shallow submarine bank that lies south of Nova Scotia and east of Cape Cod and bounds the seaward side of the Gulf of Maine. The international boundary between Canada and the United States transects the bank, and the eastern part of the bank (~7500 square kilometres) lies in Canadian territory. This map shows the surficial geology of a part of Georges Bank at a scale of 1:50 000. This map has companion topographic and backscatter strength maps. These companion maps provide a basis for interpreting the origin of seafloor features and the nature of materials that form the seafloor. The maps are based on multibeam-sonar surveys conducted in 1999 and 2000 to map 11,965 square kilometres of the seafloor.

ST. LOUIS ENCEPHALITIS

PubMed Central

Smith, Margaret G.; Blattner, Russell J.; Heys, Florence M.

1946-01-01

A colony of chicken mites (Dermanyssus gallinae) was established from a single adult female mite and her offspring. This colony of mites was shown to be free of the virus of St. Louis encephalitis. Infection of mites from this homogeneous colony with the virus of St. Louis encephalitis was accomplished by feeding on chickens having viremia. The virus was recovered as readily from mites which had not been allowed to feed for 8 days as from mites freshly engorged, showing that the demonstration of virus in the mites does not depend on the presence of fresh infective chicken blood. Transovarian passage of the St. Louis virus into the second generation has been demonstrated in mites infected experimentally. The female mite infected as an adult can pass the St. Louis virus through eggs laid after additional feeding on normal blood. Persistence of the virus for a period of 6 months has been shown in a colony of mites infected experimentally in the laboratory. PMID:19871548

How to boost soundscapes with tax breaks-On the application of Henry George's environmental economics to noise annoyance

NASA Astrophysics Data System (ADS)

Hehner, Cay

2004-05-01

The improvement of the characteristic soundscape in a given metropolitan area depends largely on a varied number of parameters not the least of which are economic. The way to sustain a large city not only economically responsible behavior patterns and activities are required, but ecologically viable ones as well. And, not coincidentally, if both patterns come into balance, a reduction of noise annoyance ensues. The cohesive set of measures that would provide the framework to ensure that the necessary economic activity is not antagonistic to (acoustic) ecology is provided by the US economist Henry George who advocated a comprehensive tax on land and all natural resources to replace eventually the bulk of all taxes checking production. New data will be provided in this paper to show the results of the application of a Georgist approach of eco-taxation to the improvement of sound quality and the reduction of noise annoyance.

[Effect of moxa-burning heat stimulating Liangmen (ST 21) and Zusanli (ST 36) on proliferation and apoptosis signaling proteins in rats with stress-induced gastric ulcer].

PubMed

Peng, Li; Wang, Yadong; Chang, Xiaorong; Wu, Huangan; Liu, Mi; Wang, Hong; Chen, Jiaolong; Wang Chao; Quan, Renfu; Yang, Zongbao

2016-06-01

To observe the effect of moxa-burning heat stimulating acupoints of Liangmen (ST 21) and Zusanli (ST 36) on the proliferation and apoptosis signaling proteins in rats with stress-induced gastric ulcer. Forty rats were randomly divided into four groups: negative control (NC), ulcer control (UC), acupoints of stomach meridian (ASM), and acupoints control (AC). The acute gastric ulcer model was established by bound and water immersion. Rats in NC and UC groups didn't receive any moxa-burning heat stimulating treatment, while rats in ASM and AC groups were treated with buringmoxa heat stimulating the acupoints of Liangmen (ST 21) and Zusanli (ST 36) and their controlled points, respectively. Rats in all groups were sacrificed after 12 consecutive days treatment. The ulcer index was evaluated by using Guth's method. The expression of tumor necrosis factor-alpha (TNF-α), apoptotic protease activating facter-1 (Apaf-1), Caspase-3, p21 activated kinase 1 (PAK1), extracellular regulated protein kinases 2 (ERK2), phosphorylated ERK2 (pERK2), phosphoinositide 3-kinase (PI3K) and RAC-alpha serine/threonine-protein kinase (Akt) in gastric mucosa was detected by enzyme linked immunosorbent assay (ELISA). Compared with UC group, the ulcer index of ASM and AC groups decreased, and the injured gastric mucosa was improved, the expression of TNF-α, Apaf-1 and Caspase-3 in gastric mucosa was significantly reduced (P < 0.05), while the expression of PAK1, ERK2, pERK2, PI3K and Akt in gastric mucosa was significantly increased (P < 0.05). And ASM showed better effect than AC group (P < 0.05). Moxa-burning Heat stimulating of Liangmen (ST 21) and Zusanli (ST 36) could promote the recovery of gastric mucosal lesion probably by inhibiting cell apoptosis and promoting cell proliferation in stress-induced gastric ulcer.

Mt. St. Helens

NASA Image and Video Library

2001-10-22

This 3-D anaglyph image of Mt. St. Helens volcano combines the nadir-looking and back-looking band 3 images of ASTER. To view the image in stereo, you will need blue-red glasses. Make sure to look through the red lens with your left eye. This ASTER image of Mt. St. Helens volcano in Washington was acquired on August 8, 2000 and covers an area of 37 by 51 km. Mount Saint Helens, a volcano in the Cascade Range of southwestern Washington that had been dormant since 1857, began to show signs of renewed activity in early 1980. On 18 May 1980, it erupted with such violence that the top of the mountain was blown off, spewing a cloud of ash and gases that rose to an altitude of 19 kilometers. The blast killed about 60 people and destroyed all life in an area of some 180 square kilometers (some 70 square miles), while a much larger area was covered with ash and debris. It continues to spit forth ash and steam intermittently. As a result of the eruption, the mountain's elevation decreased from 2,950 meters to 2,549 meters. The image is centered at 46.2 degrees north latitude, 122.2 degrees west longitude. http://photojournal.jpl.nasa.gov/catalog/PIA11160

Site inspection addendum. Fort Meade feasibility study and remedial investigation/site inspection Fort George G. Meade, Maryland. Revision 1. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-12-01

This Site Inspection Addendum Report has been prepared to address the Site Inspection portion of the Feasibility Study (FS) and Remedial Investigation/Site Inspection (RI/SI) activities at Fort George G. Meade. It has been prepared under Delivery Order No. 009 and a Change Order dated July 15, 1993, for the U.S. Army Environmental Center (USAEC), formerly known as the U.S. Army Toxic and Hazardous Materials Agency (USATHAMA). This report fulfills the requirements of deliverable ELIN A004 under Delivery Order 0009 of the Total Environmental Program Support (TEPS) contract DAAAl5-91-D-00l6. The purpose of this Site Inspection Addendum (SIA) report is to reportmore » the findings of Arthur D. Little`s SIA investigation. The overall purpose of an SI is to evaluate if chemical releases or potential contamination has occurred at suspected sites and to determine if further investigation is warranted. This study is an addendum to a previous SI and addresses data gaps remaining from or identified in that document. Six sites at Fort George G. Meade (FGGM) are included in the SIA: DPDO Salvage Yard and Transform Storage Area; DPDO Salvage Yard and Transformer Storage Area; Fire Training Area; Helicopter Hangar Area; Inactive Landfill No. 2, Ordnance Demolition Area Soldiers Lake.« less

Malignant lymphomas: results and observations from St George's Hospital.

PubMed Central

Lee, R.; Tungekar, M. F.; Harmer, C. L.; Rose, M. S.

1981-01-01

With both Hodgkin's and non-Hodgkin's lymphoma, the results documented compared well with reference series. Hence the advantages of a modest clinic need not be at the cost of recovery or of survival. A major factor attenuating the scale of therapy in Hodgkin's disease is the risk of inducing second malignancies. Four such complications have been observed amongst 27 patients with Hodgkin's disease. Amongst the patients with non-Hodgkin's lymphoma better results were noted than the designation 'poor prognosis histology' had led the authors to expect. These findings suggest that the concept of histologically based prognosis may be over-subscribed and that contemporary therapeutic strategies can be extremely effective in this group. PMID:7312734

Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels.

PubMed

Leuner, Kristina; Kazanski, Victor; Müller, Margarethe; Essin, Kirill; Henke, Bettina; Gollasch, Maik; Harteneck, Christian; Müller, Walter E

2007-12-01

Hyperforin, a bicyclic polyprenylated acylphloroglucinol derivative, is the main active principle of St. John's wort extract responsible for its antidepressive profile. Hyperforin inhibits the neuronal serotonin and norepinephrine uptake comparable to synthetic antidepressants. In contrast to synthetic antidepressants directly blocking neuronal amine uptake, hyperforin increases synaptic serotonin and norepinephrine concentrations by an indirect and yet unknown mechanism. Our attempts to identify the molecular target of hyperforin resulted in the identification of TRPC6. Hyperforin induced sodium and calcium entry as well as currents in TRPC6-expressing cells. Sodium currents and the subsequent breakdown of the membrane sodium gradients may be the rationale for the inhibition of neuronal amine uptake. The hyperforin-induced cation entry was highly specific and related to TRPC6 and was suppressed in cells expressing a dominant negative mutant of TRPC6, whereas phylogenetically related channels, i.e., TRPC3 remained unaffected. Furthermore, hyperforin induces neuronal axonal sprouting like nerve growth factor in a TRPC6-dependent manner. These findings support the role of TRPC channels in neurite extension and identify hyperforin as the first selective pharmacological tool to study TRPC6 function. Hyperforin integrates inhibition of neurotransmitter uptake and neurotrophic property by specific activation of TRPC6 and represents an interesting lead-structure for a new class of antidepressants.

Surface energy balance and turbulence measurements on Warszawa Icefield, King George Island, West Antarctica

NASA Astrophysics Data System (ADS)

Falk, U.; Sala, H.; Braun, M.

2012-12-01

The Antarctic Peninsula is amongst the fastest warming places on Earth and further temperature increase is to be expected. It has undergone rapid environmental changes in the past decades. Exceptional rates of surface air temperature increases (2.5K in 50 years) are concurrent with retreating glacier fronts, an increase in melt areas, surface lowering and rapid retreat of glaciers, break-up and disintegration of ice shelves. The South Shetland Islands are located on the northern tip of the Antarctic Peninsula and are especially vulnerable to climate change due to their maritime climate. For King George Island we have compiled a unique data set comprising direct measurements of evaporation and sensible heat flux by eddy covariance on the Warszawa Icefield over 1.5 years from November 2010 to 2012 in combination with a fully equipped automated weather station measuring long- and short-wave radiation components, profiles of temperature, humidity and wind velocities as well as glacier ice temperatures. The combination with the eddy covariance data allows for analysis of variability and seasonality of surface energy balance components on a glacier for one and a half years. Repeat measurements of snow accumulation and surface lowering along transects on the glacier and at different locations on King George Island are used for analysis of multi-sensor satellite data to identify melt patterns and bare ice areas during summer within the source area of the ground measurements. In combination with long-term time series of weather data, these data give indication of the sensitivity of the ice cap to the ongoing changes. This research is part of the ESF project IMCOAST funded by BMBF. Field work was carried out at the Dallmann laboratory (Carlini station, King George Island/Isla 25 de Mayo) in cooperation of the Instituto Antartico Argentino (Argentina) and the Alfred-Wegener Institute of Marine and Polar Research (Germany).

George A. Miller (1920-2012).

PubMed

Pinker, Steven

2013-09-01

Presents an obituary for George A. Miller (1920-2012). Miller ranks among the most important psychologists of the 20th century. In addition to writing one of the best known papers in the history of psychology ("The Magical Number Seven, Plus or Minus Two: Some Limits on Our Capacity for Processing Information," published in Psychological Review in 1956), Miller also fomented the cognitive revolution, invented psycholinguistics and cognitive psychology, imported powerful ideas from the theories of information, communication, grammar, semantics, and artificial intelligence, and left us a sparkling oeuvre that proves that a rigorous scientist needn't write in soggy prose. Honors rained down on Miller. APA gave him the Award for Distinguished Scientific Contributions (1963), the American Psychological Foundation Gold Medal Award for Life Achievement in Psychological Science (1990), the William James Book Award (1992, for The Science of Words), and the Award for Lifetime Contributions to Psychology (2003), and named a prize after him, as did the Cognitive Neuroscience Society. Miller was also honored by the Association for Psychological Science and the American Speech and Hearing Association. In 2000, he won the John P. McGovern Award in the Behavioral Sciences from the American Association for the Advancement of Science, and in 1991, the National Medal of Science, the country's highest scientific honor. © 2013 APA, all rights reserved.

Striding Out in the Opposite Direction: The Journalism Career of George Samuel Schuyler, Iconoclast.

ERIC Educational Resources Information Center

Fleener, Nickieann

Written in a biographical framework, an overview of George Samuel Schuyler's life and his career in journalism is presented in this paper. The preparation that Schuyler had for his career, the positions within journalism he held, and the major writing projects he undertook are discussed. The question of whether there is anything unique or…

The George C. Marshall Space Flight Center High Reynolds Number Wind Tunnel Technical Handbook

NASA Technical Reports Server (NTRS)

Gwin, H. S.

1975-01-01

The High Reynolds Number Wind Tunnel at the George C. Marshall Space Flight Center is described. The following items are presented to illustrate the operation and capabilities of the facility: facility descriptions and specifications, operational and performance characteristics, model design criteria, instrumentation and data recording equipment, data processing and presentation, and preliminary test information required.

Construction of a Creative and Self-Transcending Life: George Sudarshan's Conception and Experience of Creativity

ERIC Educational Resources Information Center

Raina, Maharaj

2013-01-01

This article presents a philosophical perspective on creativity as described in the writings of George Sudarshan, a highly accomplished theoretical physicist and natural philosopher whose vision of creativity was influenced by "the direct experience of transcendence." The article reviews his conceptualization of the various mental states…

Health Policy Responsiveness: Lessons Learned from Maryland and Prince George's County.

PubMed

Sogie-Thomas, Byron; Sankofa, John; Reed, Crystal; Mfume, Kweisi; Doamekpor, Lauren Abla

2018-04-01

Effective, timely, and intentional policy efforts can significantly impact and improve the public's health and reduce racial and ethnic health disparities across the nation. Creating and implementing responsive policies at the state and county level is essential to supporting community efforts to improve health behaviors and health outcomes, particularly for communities of color who bear the brunt of disease risk and negative health outcomes. Using policy examples from the State of Maryland and Prince George's County, the largest and wealthiest predominately African-American county in the USA, this case study highlights the importance of state and county policy action when presented with opportunities to affect long-lasting, positive change. We examine each jurisdiction's policy response through the lens of timeliness, intentionality, and effectiveness. At first glance, it would appear that Maryland responded effectively to the rise in tobacco use. Similarly, at face value, it appears that Prince George's County's unchecked rise in obesity rates among African-Americans is an example of nonresponsiveness among local policymakers in the face of an obesity epidemic. However-guided by a more nuanced understanding of "policy responsiveness"-this analysis uncovers a more revealing picture, with important strengths and limitations seen in both policy situations. This analysis raises critical questions about the determinants of jurisdictions' health policy capacity and how policymakers might best be supported in their efforts to build an arsenal of health policies that are timely, effective, and intentional in meeting the needs of vulnerable communities.

Georg Neumayer and Melbourne Observatory: an institutional legacy

NASA Astrophysics Data System (ADS)

Gillespie, Richard

This paper assesses Georg Neumayer's impact on the Victorian scientific community, and especially his role in the establishment of Melbourne Observatory as a major scientific institution in colonial Australia. Neumayer's arrival in Melbourne to pursue his own scientific project triggered a chain of events that would lead to the creation of Melbourne Observatory and the integration of Neumayer's geomagnetic and meteorological research into the ongoing program of the observatory. The location of the observatory in South Yarra was a direct result of Neumayer's insistence that the site was the most suitable for geomagnetic measurement. Most critically, Neumayer's attempts to get approval for his project highlighted the need for local scientists to establish political and scientific alliances that would ensure endorsement by international, notably British, scientists, and that would persuade local elites and government of the practical value of their research.

Estrogenic Activity of Hyperforin in MCF-7 Human Breast Cancer Cells Transfected with Estrogen Receptor.

PubMed

Kwon, Joseph; Oh, Kyung Seo; Cho, Se-Young; Bang, Mi Ae; Kim, Hwan Seon; Vaidya, Bipin; Kim, Duwoon

2016-11-01

Hyperforin, a major active compound of St. John's wort extract, affects estrogenic activity. In this study, the compound evoked estrogen response element-dependent luciferase activity and cell proliferation in MCF-7 cells. Hyperforin-induced cell proliferation was significantly inhibited by the estrogen receptor antagonist ICI 182,780. These results suggested that hyperforin had estrogenic and cell proliferation activities, which were stimulated via the estrogen receptor. Compared to 17 β -estradiol, hyperforin showed significantly lower estrogenic activity and cell proliferation. The mechanism underlying the estrogenic activity of hyperforin was unknown, therefore, in this study, for the first time, the expression and post-translational modification of proteins were determined and compared among control, 17 β -estradiol-treated, and hyperforin-treated cells using proteomic techniques. A total of 453 proteins were identified, of which 282 proteins were significantly modulated in hyperforin-treated cells compared to 17 β -estradiol-treated cells. Ingenuity pathway analysis also demonstrated that hyperforin treatment induced less cell proliferation than 17 β -estradiol by downregulating estrogen receptor 1. Protein network analysis showed that cell proliferation was regulated mainly by cyclin D1 and extracellular signal-regulated kinases. In conclusion, although, hyperforin exhibited lower estrogenic activity than 17 β -estradiol, the compound induced lower levels of cancer cell proliferation in vitro . Georg Thieme Verlag KG Stuttgart · New York.

Lichen flora around the Korean Antarctic Scientific Station, King George Island, Antarctic.

PubMed

Kim, Ji Hee; Ahn, In-Young; Hong, Soon Gyu; Andreev, Mikhail; Lim, Kwang-Mi; Oh, Mi Jin; Koh, Young Jin; Hur, Jae-Seoun

2006-10-01

As part of the long-term monitoring projects on Antarctic terrestrial vegetation in relation to global climate change, a lichen floristical survey was conducted around the Korean Antarctic Station (King Sejong Station), which is located on Barton Peninsula, King George Island, in January and February of 2006. Two hundred and twenty-five lichen specimens were collected and sixty-two lichen species in 38 genera were identified by morphological characteristics, chemical constituents, TLC analysis and ITS nucleotide sequence analysis.

Comparative analysis of the attitudes and perceptions of three types of lake george boaters

Treesearch

Nancy A. Connelly; Tommy L. Brown; Timothy Holmes; Michael White

2007-01-01

The experiences and concerns of three types of Lake George recreational boaters were assessed to see if different levels of investment and experience with the lake lead to potentially different perceptions and concerns regarding congestion, overcrowding, and safety hazards on the lake. Mail questionnaires were sent out in the summer/fall of 2005 to the three types of...

Genetic Modifiers of the Physical Malformations in Velo-Cardio-Facial Syndrome/DiGeorge Syndrome

ERIC Educational Resources Information Center

Aggarwal, Vimla S.; Morrow, Bernice E.

2008-01-01

Velo-cardio-facial syndrome/DiGeorge syndrome (VCFS/DGS), the most common micro-deletion disorder in humans, is characterized by craniofacial, parathyroid, and thymic defects as well as cardiac outflow tract malformations. Most patients have a similar hemizygous 3 million base pair deletion on 22q11.2. Studies in mouse have shown that "Tbx1", a…

ST09, a Novel Thioester Derivative of Tacrine, Alleviates Cognitive Deficits and Enhances Glucose Metabolism in Vascular Dementia Rats.

PubMed

Liu, Jian-Min; Wu, Peng-Fei; Rao, Jing; Zhou, Jun; Shen, Zu-Cheng; Luo, Han; Huang, Jian-Geng; Liang, Xiao; Long, Li-Hong; Xie, Qing-Guo; Jiang, Feng-Chao; Wang, Fang; Chen, Jian-Guo

2016-03-01

Chemical entities containing mercapto group have been increasingly attractive in the therapy of central nerve system (CNS) diseases. In the recent study, we screened a series of mercapto-tacrine derivatives with synergistic neuropharmacological profiles in vitro. We investigated the effect and mechanism of ST09, a thioester derivative of tacrine containing a potential mercapto group, on the vascular dementia (VaD) model of rat induced by bilateral common carotid arteries occlusion (2-VO). ST09 and its active metabolite ST10 retained excellent inhibition on acetylcholinesterase (AChE) activity. ST09 significantly attenuated the 2-VO-induced impairment in spatial acquisition performance and inhibited the 2-VO-induced rise of AChE activity. In the VaD model, ST09 attenuated the oxidative stress and decreased the apoptosis in the cortex and hippocampus. Compared with donepezil, ST09 exhibited a better effect on the regeneration of free thiols in 2-VO rats. Interestingly, ST09, not donepezil, greatly improved glucose metabolism in various brain regions of 2-VO rats using functional imaging of (18) F-labeled fluoro-deoxyglucose (FDG) positron emission tomography (PET). ST09 may serve as a more promising agent for the therapy of VaD than tacrine owing to the introduction of a potential mercapto group into the parent skeleton. © 2016 John Wiley & Sons Ltd.

Polyphenolic substrates and dyes degradation by yeasts from 25 de Mayo/King George Island (Antarctica).

PubMed

Rovati, José I; Pajot, Hipólito F; Ruberto, Lucas; Mac Cormack, Walter; Figueroa, Lucía I C

2013-11-01

Antarctica offers a range of extreme climatic conditions, such as low temperatures, high solar radiation and low nutrient availability, and constitutes one of the harshest environments on Earth. Despite that, it has been successfully colonized by ’cold-loving’ fungi, which play a key role in decomposition cycles in cold ecosystems. However, knowledge about the ecological role of yeasts in nutrient or organic matter recycling/mineralization remains highly fragmentary. The aim of this work was to study the yeast microbiota in samples collected on 25 de Mayo/King George Island regarding the scope of their ability to degrade polyphenolic substrates such as lignin and azo dyes. Sixty-one yeast isolates were obtained from 37 samples, including soil, rocks, wood and bones. Molecular analyses based on rDNA sequences revealed that 35 yeasts could be identified at the species level and could be classified in the genera Leucosporidiella, Rhodotorula, Cryptococcus, Bullera and Candida. Cryptococcus victoriae was by far the most ubiquitous species. In total, 33% of the yeast isolates examined showed significant activity for dye decolorization, 25% for laccase activity and 38% for ligninolytic activity. Eleven yeasts did not show positive activity in any of the assays performed and no isolates showed positive activity across all tested substrates. A high diversity of yeasts were isolated in this work, possibly including undescribed species and conspicuous Antarctic yeasts, most of them belonging to oligotrophic, slow-growing and metabolically diverse basidiomycetous genera.

78 FR 16211 - Safety Zone, Corp. Event Finale UHC, St. Thomas Harbor; St. Thomas, U.S. Virgin Islands

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-14

... 1625-AA00 Safety Zone, Corp. Event Finale UHC, St. Thomas Harbor; St. Thomas, U.S. Virgin Islands... establish a temporary safety zone on the waters of St. Thomas Harbor in St. Thomas, U.S. Virgin Islands... near the St. Thomas Harbor channel from which fireworks will be lit. DATES: Comments and related...

Indiana University-Purdue University Indianapolis and George Washington Community High School: Educating Their Communities Together

ERIC Educational Resources Information Center

Officer, Starla D. H.; Bringle, Robert G.; Grim, Jim

2011-01-01

Indiana University-Purdue University Indianapolis worked with the residents and leadership of three neighborhoods adjacent to the campus to reopen the closed George Washington High School. The resulting partnership has strengthened the civic engagement mission of the university, and contributed to an award-winning community-based school. The…

George A. Olah, Carbocation and Hydrocarbon Chemistry

Science.gov Websites

. Final Technical Report. [HF:BF{sub 2}/H{sub 2}] , DOE Technical Report, 1980 Superacid Catalyzed Coal Conversion Chemistry. 1st and 2nd Quarterly Technical Progress Reports, September 1, 1983-March 30, 1984 , DOE Technical Report, 1984 Superacid Catalyzed Coal Conversion Chemistry. Final Technical Report

78 FR 16208 - Safety Zone; V. I. Carnival Finale; St. Thomas Harbor; St. Thomas, U.S. Virgin Islands

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-14

... 1625-AA00 Safety Zone; V. I. Carnival Finale; St. Thomas Harbor; St. Thomas, U.S. Virgin Islands AGENCY... establish a safety zone on the waters of St. Thomas Harbor in St. Thomas, U. S. Virgin Islands during the V..., 2013, and will entail a barge being positioned near the St. Thomas Harbor channel from which fireworks...

78 FR 23489 - Safety Zone; V.I. Carnival Finale, St. Thomas Harbor; St. Thomas, U.S.V.I.

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-19

...-AA00 Safety Zone; V.I. Carnival Finale, St. Thomas Harbor; St. Thomas, U.S.V.I. AGENCY: Coast Guard... waters of St. Thomas Harbor in St. Thomas, U.S. Virgin Islands during the V.I. Carnival Finale, a... being positioned near the St. Thomas Harbor channel from which fireworks will be lit. The safety zone is...

78 FR 22778 - Safety Zone; Corp. Event Finale UHC, St. Thomas Harbor; St. Thomas, U.S.V.I.

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-17

...-AA00 Safety Zone; Corp. Event Finale UHC, St. Thomas Harbor; St. Thomas, U.S.V.I. AGENCY: Coast Guard... waters of St. Thomas Harbor in St. Thomas, U.S. Virgin Islands during the Corp. Event Finale UHC, a... barge being positioned near the St. Thomas Harbor channel from which fireworks will be lit. The safety...

Antibody-Mediated Killing of Carbapenem-Resistant ST258 Klebsiella pneumoniae by Human Neutrophils

PubMed Central

Kobayashi, Scott D.; Porter, Adeline R.; Freedman, Brett; Pandey, Ruchi; Chen, Liang; Kreiswirth, Barry N.

2018-01-01

ABSTRACT Carbapenem-resistant Klebsiella pneumoniae is a problem worldwide. A carbapenem-resistant K. pneumoniae lineage classified as multilocus sequence type 258 (ST258) is prominent in the health care setting in many regions of the world, including the United States. ST258 strains can be resistant to virtually all clinically useful antibiotics; treatment of infections caused by these organisms is difficult, and mortality is high. As a step toward promoting development of new therapeutics for ST258 infections, we tested the ability of rabbit antibodies specific for ST258 capsule polysaccharide to enhance human serum bactericidal activity and promote phagocytosis and killing of these bacteria by human neutrophils. We first demonstrated that an isogenic wzy deletion strain is significantly more susceptible to killing by human heparinized blood, serum, and neutrophils than a wild-type ST258 strain. Consistent with the importance of capsule as an immune evasion molecule, rabbit immune serum and purified IgG specific for ST258 capsule polysaccharide type 2 (CPS2) enhanced killing by human blood and serum in vitro. Moreover, antibodies specific for CPS2 promoted phagocytosis and killing of ST258 by human neutrophils. Collectively, our findings suggest that ST258 CPS2 is a viable target for immunoprophylactics and/or therapeutics. PMID:29535199

EMSL Quarterly Highlights Report: 1st Quarter, Fiscal Year 2009

DOE Office of Scientific and Technical Information (OSTI.GOV)

Showalter, Mary Ann; Kathmann, Loel E.; Manke, Kristin L.

2009-02-02

The EMSL Quarterly Highlights Report covers the science, staff and user recognition, and publication activities that occurred during the 1st quarter (October 2008 - December 2008) of Fiscal Year 2009.

76 FR 55158 - Approval of Noise Compatibility Program for Lambert-St. Louis International Airport, St. Louis, MO

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-06

... Program for Lambert-St. Louis International Airport, St. Louis, MO AGENCY: Federal Aviation Administration... noise compatibility program submitted by the St. Louis Airport Authority under the provisions of 49 U.S...''). On April 5, 2011, the FAA determined that the noise exposure maps submitted by the St. Louis Airport...

Presence of selected chemicals of emerging concern in water and bottom sediment from the St. Louis River, St. Louis Bay, and Superior Bay, Minnesota and Wisconsin, 2010

USGS Publications Warehouse

Christensen, Victoria G.; Lee, Kathy E.; Kieta, Kristen A.; Elliott, Sarah M.

2012-01-01

The St. Louis Bay of Lake Superior receives substantial urban runoff, wastewater treatment plant effluent, and industrial effluent. In 1987, the International Joint Commission designated the St. Louis Bay portion of the lower St. Louis River as one of the Great Lakes Areas of Concern. Concerns exist about the potential effects of chemicals of emerging concern on aquatic biota because many of these chemicals, including endocrine active chemicals, have been shown to affect the endocrine systems of fish. To determine the occurrence of chemicals of emerging concern in the St. Louis River, the St. Louis Bay, and Superior Bay, the U.S. Geological Survey in cooperation with the Minnesota Pollution Control Agency and the Wisconsin Department of Natural Resources collected water and bottom-sediment samples from 40 sites from August through October 2010. The objectives of this study were to (1) identify the extent to which chemicals of emerging concern, including pharmaceuticals, hormones, and other organic chemicals, occur in the St. Louis River, St. Louis Bay, and Superior Bay, and (2) identify the extent to which the chemicals may have accumulated in bottom sediment of the study area. Samples were analyzed for selected wastewater indicators, hormones, sterols, bisphenol A, and human-health pharmaceuticals. During this study, 33 of 89 chemicals of emerging concern were detected among all water samples collected and 56 of 104 chemicals of emerging concern were detected in bottom-sediment samples. The chemical N,N-diethyl-meta-toluamide (DEET) was the most commonly detected chemical in water samples and 2,6-dimethylnaphthalene was the most commonly detected chemical in bottom-sediment samples. In general, chemicals of emerging concern were detected at a higher frequency in bottom-sediment samples than in water samples. Estrone (a steroid hormone) and hexahydrohexamethyl cyclopentabensopyran (a synthetic fragrance) were the most commonly detected endocrine active chemicals in

[Development of an activity of daily living scale for patients with COPD: the Activity of Daily Living Dyspnea scale].

PubMed

Yoza, Yoshiyasu; Ariyoshi, Koya; Honda, Sumihisa; Taniguchi, Hiroyuki; Senjyu, Hideaki

2009-10-01

Patients with COPD often experience restriction in their activities of daily living (ADL) due to dyspnea. This type of restriction is unique to patients with COPD and cannot be adequately evaluated by the generic ADL scales. This study developed an ADL scale (the Activity of Daily Living Dyspnea scale [ADL-D scale]) for patients with COPD and investigated its validity and internal consistency. Patients with stable COPD were recruited and completed a pilot 26-item questionnaire. Patients also performed the Incremental Shuttle Walk Test (ISWT), and completed the St George's Respiratory Questionnaire (SGRQ), and Medical Research Council (MRC) dyspnea grade. There were 83 male participants who completed the pilot questionnaire. Following the pilot, 8 items that were not undertaken by the majority of subjects, and 3 items judged to be of low clinical importance by physical therapists were removed from the pilot questionnaire. The final ADL-D scale contained 15 items. Scores obtained with the ADL-D scale were significantly correlated with the MRC dyspnea grades, distance walked on the ISWT and SGRQ scores. The ADL-D scores were significantly different across the five grades of the MRC dyspnea grade. The ADL-D scale showed high consistency (Chronbach's alpha coefficient of 0.96). The ADL-D scale is a useful scale for assessing impairments in ADL in Japanese male patients with COPD.

Computerized Farm of the 21st Century.

ERIC Educational Resources Information Center

McGrann, James M.

Advancement in computer technology comes at a time when agriculture is in transition from a production-oriented to a business-oriented activity and will require new skills and knowledge if farmers are to be prepared for the future. Electronic technology applications on 21st century commercial farms and ranches will include farm decision support…

4. VIEW OF BLUBBERING ROOM Each skin was put on ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. VIEW OF BLUBBERING ROOM Each skin was put on a metal mold and stripped of its blubber with a curved knife. The blubber ran off to the left to barrels outside, where it was saved for use in preserving the texture of the skins. - Sealing Plant, St. George Island, Pribilof Islands, Saint George, Aleutians West Census Area, AK

The spread of KPC-producing Enterobacteriaceae in Spain: WGS analysis of the emerging high-risk clones of Klebsiella pneumoniae ST11/KPC-2, ST101/KPC-2 and ST512/KPC-3.

PubMed

Oteo, Jesús; Pérez-Vázquez, María; Bautista, Verónica; Ortega, Adriana; Zamarrón, Pilar; Saez, David; Fernández-Romero, Sara; Lara, Noelia; Ramiro, Raquel; Aracil, Belén; Campos, José

2016-12-01

We analysed the microbiological traits and population structure of KPC-producing Enterobacteriaceae isolates collected in Spain between 2012 and 2014. We also performed a comparative WGS analysis of the three major KPC-producing Klebsiella pneumoniae clones detected. Carbapenemase and ESBL genes were sequenced. The Institut Pasteur MLST scheme was used. WGS data were used to construct phylogenetic trees, to identify the determinants of resistance and to de novo assemble the genome of one representative isolate of each of the three major K. pneumoniae clones. Of the 2443 carbapenemase-producing Enterobacteriaceae isolates identified during the study period, 111 (4.5%) produced KPC. Of these, 81 (73.0%) were K. pneumoniae and 13 (11.7%) were Enterobacter cloacae. Three major epidemic clones of K. pneumoniae were identified: ST11/KPC-2, ST101/KPC-2 and ST512/KPC-3. ST11/KPC-2 differed from ST101/KPC-2 and ST512/KPC-3 by 27 819 and 6924 SNPs, respectively. ST101/KPC-2 differed from ST512/KPC-3 by 28 345 SNPs. Nine acquired resistance genes were found in ST11/KPC-2, 11 in ST512/KPC-3 and 13 in ST101/KPC-2. ST101/KPC-2 had the highest number of virulence genes (20). An 11 bp deletion at the end of the mgrB sequence was the cause of colistin resistance in ST512/KPC-3. KPC-producing Enterobacteriaceae are increasing in Spain. Most KPC-producing K. pneumoniae isolates belonged to only five clones: ST11 and ST512 caused interregional spread, ST101 caused regional spread and ST1961 and ST678 produced independent hospital outbreaks. ST101/KPC-2 had the highest number of resistance and virulence genes. ST101/KPC-2 and ST512/KPC-3 were recently implicated in the spread of KPC in Italy. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

The spread of KPC-producing Enterobacteriaceae in Spain: WGS analysis of the emerging high-risk clones of Klebsiella pneumoniae ST11/KPC-2, ST101/KPC-2 and ST512/KPC-3

PubMed Central

Oteo, Jesús; Pérez-Vázquez, María; Bautista, Verónica; Ortega, Adriana; Zamarrón, Pilar; Saez, David; Fernández-Romero, Sara; Lara, Noelia; Ramiro, Raquel; Aracil, Belén; Campos, José

2016-01-01

Objectives We analysed the microbiological traits and population structure of KPC-producing Enterobacteriaceae isolates collected in Spain between 2012 and 2014. We also performed a comparative WGS analysis of the three major KPC-producing Klebsiella pneumoniae clones detected. Methods Carbapenemase and ESBL genes were sequenced. The Institut Pasteur MLST scheme was used. WGS data were used to construct phylogenetic trees, to identify the determinants of resistance and to de novo assemble the genome of one representative isolate of each of the three major K. pneumoniae clones. Results Of the 2443 carbapenemase-producing Enterobacteriaceae isolates identified during the study period, 111 (4.5%) produced KPC. Of these, 81 (73.0%) were K. pneumoniae and 13 (11.7%) were Enterobacter cloacae. Three major epidemic clones of K. pneumoniae were identified: ST11/KPC-2, ST101/KPC-2 and ST512/KPC-3. ST11/KPC-2 differed from ST101/KPC-2 and ST512/KPC-3 by 27 819 and 6924 SNPs, respectively. ST101/KPC-2 differed from ST512/KPC-3 by 28 345 SNPs. Nine acquired resistance genes were found in ST11/KPC-2, 11 in ST512/KPC-3 and 13 in ST101/KPC-2. ST101/KPC-2 had the highest number of virulence genes (20). An 11 bp deletion at the end of the mgrB sequence was the cause of colistin resistance in ST512/KPC-3. Conclusions KPC-producing Enterobacteriaceae are increasing in Spain. Most KPC-producing K. pneumoniae isolates belonged to only five clones: ST11 and ST512 caused interregional spread, ST101 caused regional spread and ST1961 and ST678 produced independent hospital outbreaks. ST101/KPC-2 had the highest number of resistance and virulence genes. ST101/KPC-2 and ST512/KPC-3 were recently implicated in the spread of KPC in Italy. PMID:27530752

Phrenology, Education, and the Politics of Human Nature: The Thought and Influence of George Combe.

ERIC Educational Resources Information Center

Tomlinson, Stephen

1997-01-01

Reviews the career and contributions of George Combe, an Edinburgh lawyer who proselytized for the cause of using phrenology in education. Although dismissed today as pseudoscience, phrenology (attributing various character traits to specific locations in the brain) was taken seriously as a science during the early 19th century. (MJP)

A 2,000-year record of mercury and ancient civilizations in seal hairs from King George Island, West Antarctica.

PubMed

Sun, Liguang; Yin, Xuebin; Liu, Xiaodong; Zhu, Renbin; Xie, Zhouqing; Wang, Yuhong

2006-09-01

The concentrations of total mercury (Hg(T)) and three bio-essential elements (phosphor, potassium, sodium) were analyzed in Antarctic seal hairs from a lake core spanning the past 2,000 years and collected from King George Island (63 degrees 23'S, 57 degrees 00'W), West Antarctica. The Hg(T) concentration shows a significant fluctuation while the levels of the three bio-essential elements remain almost constant. The rise and fall of the Hg(T) concentration in the seal hairs are found to be closely coincided with ancient activities of gold and silver mining using Hg-amalgamation process around the world, especially in the Southern Hemisphere. Briefly, Hg(T) levels are high during five episodes of extensive gold and silver mining activities--Rome Empire and China Han Dynasty (approximately 18-300 A.D.), Maya period and China Tang (750-900 A.D.), Incas civilization and Christian Kingdom (1200-1500 A.D.), New world (1650-1800 A.D.), and modern industry period (1840 A.D.-present); they are low during four time periods of reduced gold and silver mining activities--the China Han and Rome fall (since 300 A.D.), Maya fall and Wartime period in China (1050-1250 A.D.), Pizarro coming (ca. 1532 A.D.) and Independence War of South America (1800-1830 A.D.). Two profiles of Hg(T) in other two lake cores, one affected by seal excrements and the other by penguin droppings, from the same region are similar to the one in seal hairs. The Hg concentration profile in the seal hairs is significantly correlated with the one in a peat bog of Southern Chile near King George Island. Since Hg is existent mainly at the form of methyl-mercury in seal hairs, this correlation supports a relationship and link between atmospheric mercury concentration and methyl-mercury production. Comparing with samples from American and European continents, the Antarctic seal hairs provide an archive of total mercury concentration in surface seawater of the South Ocean less affected by regional human activities

St. John's Wort (image)

MedlinePlus

The herb St. John's Wort is believed to be helpful in relieving mild to moderate depression, but should only be taken under a physician's supervision. St. John's Wort may clash with other medications or ...

First genome report on novel sequence types of Neisseria meningitidis: ST12777 and ST12778.

PubMed

Veeraraghavan, Balaji; Lal, Binesh; Devanga Ragupathi, Naveen Kumar; Neeravi, Iyyan Raj; Jeyaraman, Ranjith; Varghese, Rosemol; Paul, Miracle Magdalene; Baskaran, Ashtawarthani; Ranjan, Ranjini

2018-03-01

Neisseria meningitidis is an important causative agent of meningitis and/or sepsis with high morbidity and mortality. Baseline genome data on N. meningitidis, especially from developing countries such as India, are lacking. This study aimed to investigate the whole genome sequences of N. meningitidis isolates from a tertiary care centre in India. Whole-genome sequencing was performed using an Ion Torrent™ Personal Genome Machine™ (PGM) with 400-bp chemistry. Data were assembled de novo using SPAdes Genome Assembler v.5.0.0.0. Sequence annotation was performed through PATRIC, RAST and the NCBI PGAAP server. Downstream analysis of the isolates was performed using the Center for Genomic Epidemiology databases for antimicrobial resistance genes and sequence types. Virulence factors and CRISPR were analysed using the PubMLST database and CRISPRFinder, respectively. This study reports the whole genome shotgun sequences of eight N. meningitidis isolates from bloodstream infections. The genome data revealed two novel sequence types (ST12777 and ST12778), along with ST11, ST437 and ST6928. The virulence profile of the isolates matched their sequence types. All isolates were negative for plasmid-mediated resistance genes. To the best of our knowledge, this is the first report of ST11 and ST437 N. meningitidis isolates in India along with two novel sequence types (ST12777 and ST12778). These results indicate that the sequence types circulating in India are diverse and require continuous monitoring. Further studies strengthening the genome data on N. meningitidis are required to understand the prevalence, spread, exact resistance and virulence mechanisms along with serotypes. Copyright © 2017 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.

Isolation and characterization of styrene metabolism genes from styrene-assimilating soil bacteria Rhodococcus sp. ST-5 and ST-10.

PubMed

Toda, Hiroshi; Itoh, Nobuya

2012-01-01

Styrene metabolism genes were isolated from styrene-assimilating bacteria Rhodococcus sp. ST-5 and ST-10. Strain ST-5 had a gene cluster containing four open reading frames which encoded styrene degradation enzymes. The genes showed high similarity to styABCD of Pseudomonas sp. Y2. On the other hand, strain ST-10 had only two genes which encoded styrene monooxygenase and flavin oxidoreductase (styAB). Escherichia coli transformants possessing the sty genes of strains ST-5 and ST-10 produced (S)-styrene oxide from styrene, indicating that these genes function as styrene degradation enzymes. Metabolite analysis by resting-cell reaction with gas chromatography-mass spectrometry revealed that strain ST-5 converts styrene to phenylacetaldehyde via styrene oxide by styrene oxide isomerase (styC) reaction. On the other hand, strain ST-10 lacked this enzyme, and thus accumulated styrene oxide as an intermediate. HPLC analysis showed that styrene oxide was spontaneously isomerized to phenylacetaldehyde by chemical reaction. The produced phenylacetaldehyde was converted to phenylacetic acid (PAA) in strain ST-10 as well as in strain ST-5. Furthermore, phenylacetic acid was converted to phenylacetyl-CoA by the catalysis of phenylacetate-CoA ligase in strains ST-5 and ST-10. This study proposes possible styrene metabolism pathways in Rhodococcus sp. strains ST-5 and ST-10. Copyright © 2011 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Cooperative water-resources monitoring in the St. Clair River/Lake St. Clair Basin, Michigan

USGS Publications Warehouse

Rheaume, Stephen J.; Neff, Brian P.; Blumer, Stephen P.

2007-01-01

As part of the Lake St. Clair Regional Monitoring Project, this report describes numerous cooperative water-resources monitoring efforts conducted in the St. Clair River/Lake St. Clair Basin over the last 100 years. Cooperative monitoring is a tool used to observe and record changes in water quantity and quality over time. This report describes cooperative efforts for monitoring streamflows and flood magnitudes, past and present water-quality conditions, significant human-health threats, and flow-regime changes that are the result of changing land use. Water-resources monitoring is a long-term effort that can be made cost-effective by leveraging funds, sharing data, and avoiding duplication of effort. Without long-term cooperative monitoring, future water-resources managers and planners may find it difficult to establish and maintain public supply, recreational, ecological, and esthetic water-quality goals for the St. Clair River/Lake St. Clair Basin.

ST 1535: a preferential A2A adenosine receptor antagonist.

PubMed

Stasi, Maria Antonietta; Borsini, Franco; Varani, Katia; Vincenzi, Fabrizio; Di Cesare, Maria Assunta; Minetti, Patrizia; Ghirardi, Orlando; Carminati, Paolo

2006-10-01

Antagonism of the A2A adenosine function has proved beneficial in the treatment of Parkinson's disease, in that it increases L-dopa therapeutical effects without concomitant worsening of its side-effects. In this paper we describe a preferential A2A adenosine antagonist, ST 1535, with long-lasting pharmacodynamic effects. It competitively antagonizes the effects of the A2A adenosine agonist NECA on cAMP in cells cloned with the human A2A adenosine receptor (IC50=353+/-30 nM), and the effects of the A1 adenosine agonist CHA on cAMP in cells cloned with the human A1 adenosine receptor (IC50=510+/-38 nM). ST 1535, at oral doses of 5 and 10 mg/kg, antagonizes catalepsy induced by intracerebroventricular administration of the A2A adenosine agonist CGS 21680 (10 microg/5 microl) in mice. At oral doses ranging between 5 and 20 mg/kg, ST 1535 induces hypermotility and antagonizes haloperidol-induced catalepsy in mice up to 7 h. Oral ST 1535, at 1.25 and 2.5 mg/kg, potentiates L-dopa effects in reducing haloperidol-induced catalepsy. ST 1535 represents a potential new compound, with long-lasting activity, for the treatment of Parkinson's disease.

[National Consultant in Cardiology Experts' Group Guidelines on dealing with patients implanted with some St. Jude Medical Riata and Riata ST leads].

PubMed

Mitkowski, Przemysław; Grabowski, Marcin; Kowalski, Oskar; Kutarski, Andrzej; Mojkowski, Włodzimierz; Przybylski, Andrzej; Sterliński, Maciej; Trusz-Gluza, Maria; Opolski, Grzegorz

2014-01-01

In December 2010 St. Jude Medical informed about higher incidence of silicone insulation abrasion in implantable cardioverter-defibrillator leads Riata/Riata ST. The manifestation of this phenomenon is the externalisation of conductors outside the body of the lead, which is visible in a fluoroscopy. The abrasion could also involve an insulation under high-voltage coil and in the worst case could result in a short circuit within high voltage part of the system. The incidence of this phenomenon varies from part of to several dozen percent according to published papers and becomes higher in a longer follow-up. The highest probability of malfunction in 8 F single coil and the lowest in 7 F dual-coil leads is observed. For the needs of this guidelines all Riata/Riata ST leads were divided into: functioning, damaged but active (visible externalisation but electrically functioning), malfunctioning. In the last case the lead should be removed and a new one implanted (class of indication I) ,although only implantation of a new lead with abandoning malfunctioning one is allowed and should be considered (IIa). In patients with functioning lead extraction with a new lead implantation may be considered during elective replacement only in high risk patients (IIb). In case of damaged but active lead its extraction with the implantation of a new lead during elective replacement of the device should be considered in high risk population (IIa) and may be considered in other patients (IIb). The final decision related to Riata/Riata ST should be individualised and undertaken in co-operation with the patient after detailed assessment of the risk related to each treatment option.

N-linked oligosaccharides on chondroitin 6-sulfotransferase-1 are required for production of the active enzyme, Golgi localization, and sulfotransferase activity toward keratan sulfate.

PubMed

Yusa, Akiko; Kitajima, Ken; Habuchi, Osami

2006-07-21

We have shown previously that purified chondroitin 6-sulfotransferase-1 (C6ST-1) was a glycoprotein abundant in N-linked oligosaccharides and could sulfate both chondroitin (C6ST activity) and keratan sulfate (KSST activity); however, functional roles of the N-glycans have remained unclear. In the present study, we show essential roles of N-glycans attached to C6ST-1 in the generation of the active enzyme and in its KSST activity. Treatment with tunicamycin of COS-7 cells transfected with C6ST-1 cDNA totally abolished production of the active C6ST-1. A nearly complete removal of N-glycans of the recombinant C6ST-1 by peptide N-glycosidase F increased the C6ST activity but decreased the KSST activity. Among six potential N-glycosylation sites, deletion of the fourth or sixth site from the amino terminus inhibited production of the active C6ST-1, whereas deletion of the fifth site resulted in a marked loss of the KSST activity. Wild-type recombinant C6ST-1 showed a typical Golgi localization, whereas M-4 recombinant C6ST-1, in which the fourth N-glycosylation site was deleted, colocalized with calnexin, an endoplasmic reticulum-resident protein. Unlike wildtype recombinant C6ST-1, M-4 recombinant C6ST-1 showed a weak affinity toward wheat germ agglutinin and was converted completely to the nonglycosylated form by endoglycosidase H. These observations suggest that N-glycan attached to the fourth N-glycosylation site may function in the proper processing of N-glycans required for the Golgi localization, thereby causing the production of the active C6ST-1, and that N-glycan attached to the fifth N-glycosylation site may contribute to the KSST activity of C6ST-1.

75 FR 49521 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-13

... Cemetery, 2500 W Court St., Flint, 10000616 Menominee County Janson, Charles G., Garage, 524 10th Ave...., Detroit, 10000657 Finney, Jared W., School and George H. Cannon Community Center, (Public Schools of... School, (Public Schools of Detroit MPS) 744 W Adeline St., Detroit, 10000661 Greenfield Union School...

Identifying 21st Century Capabilities

ERIC Educational Resources Information Center