Massless Lüscher terms and the limitations of the AdS3 asymptotic Bethe ansatz
NASA Astrophysics Data System (ADS)
Abbott, Michael C.; Aniceto, Inês
2016-05-01
In AdS5/CFT4 integrability the Bethe ansatz gives the spectrum of long strings, accurate up to exponentially small corrections. This is no longer true in three-dimensional anti-de Sitter (AdS3 ) space, as we demonstrate here by studying Lüscher F-terms with a massless particle running in the loop. We apply this to the classic test of Hernández and López, in which the s u (2 ) sector Bethe equations (including the one-loop dressing phase) should match the semiclassical string theory result for a circular spinning string. These calculations do not agree in AdS3×S3×T4 , and we show that the sum of all massless Lüscher F-terms can reproduce the difference.
Short-term memory binding is impaired in AD but not in non-AD dementias.
Della Sala, Sergio; Parra, Mario A; Fabi, Katia; Luzzi, Simona; Abrahams, Sharon
2012-04-01
Binding is a cognitive function responsible for integrating features within complex stimuli (e.g., shape-colour conjunctions) or events within complex memories (e.g., face-name associations). This function operates both in short-term memory (STM) and in long-term memory (LTM) and is severely affected by Alzheimer's disease (AD). However, forming conjunctions in STM is the only binding function which is not affected by healthy ageing or chronic depression. Whether this specificity holds true across other non-AD dementias is as yet unknown. The present study investigated STM conjunctive binding in a sample of AD patients and patients with other non-AD dementias using a task which has proved sensitive to the effects of AD. The STM task assesses the free recall of objects, colours, and the bindings of objects and colours. Patients with AD, frontotemporal dementia, vascular dementia, lewy body dementia and dementia associated with Parkinson's disease showed memory, visuo-spatial, executive and attentional deficits on standard neuropsychological assessment. However, only AD patients showed STM binding deficits. This deficit was observed even when memory for single features was at a similar level across patient groups. Regression and discriminant analyses confirmed that the STM binding task accounted for the largest proportion of variance between AD and non-AD groups and held the greatest classification power to identify patients with AD. STM conjunctive binding places little demands on executive functions and appears to be subserved by components of the memory network which are targeted by AD, but not by non-AD dementias. PMID:22289292
Precursors, gauge invariance, and quantum error correction in AdS/CFT
NASA Astrophysics Data System (ADS)
Freivogel, Ben; Jefferson, Robert A.; Kabir, Laurens
2016-04-01
A puzzling aspect of the AdS/CFT correspondence is that a single bulk operator can be mapped to multiple different boundary operators, or precursors. By improving upon a recent model of Mintun, Polchinski, and Rosenhaus, we demonstrate explicitly how this ambiguity arises in a simple model of the field theory. In particular, we show how gauge invariance in the boundary theory manifests as a freedom in the smearing function used in the bulk-boundary mapping, and explicitly show how this freedom can be used to localize the precursor in different spatial regions. We also show how the ambiguity can be understood in terms of quantum error correction, by appealing to the entanglement present in the CFT. The concordance of these two approaches suggests that gauge invariance and entanglement in the boundary field theory are intimately connected to the reconstruction of local operators in the dual spacetime.
Dimension Six Correction to the Vector Sector of AdS/QCD Model
Hovhannes Grigoryan
2007-09-06
We study the effect of dimension six term F^3 on the predictions of the holographic model for the vector meson form factor. It is shown that the dimensionless parameter with which this term enters the action determines the corrections to the electric radius, magnetic and quadrupole moments of the rho meson. The results suggest that the addition of higher order terms may improve the holographic model.
Quantum corrections to energy of short spinning string in AdS{sub 5}
Tirziu, A.; Tseytlin, A. A.
2008-09-15
Motivated by a desire to shed light on the strong-coupling behavior of dimensions of short gauge-theory operators, we consider the famous example of folded spinning string in AdS{sub 5} in the limit of small semiclassical spin parameter S=(S/{radical}({lambda})). In this limit the string becomes short and is moving in a near-flat central region of AdS{sub 5}. Its energy scales with spin as E={radical}(2S)[a{sub 0}+a{sub 1}S+a{sub 2}S{sup 2}+...]. We explicitly compute the leading 1-loop quantum AdS{sub 5}xS{sup 5} superstring correction to the short string energy and show that the coefficient a{sub 0} is not renormalized from its classical value while a{sub 1} receives a nontrivial contribution containing {zeta}(3)
2015-11-01
In the article by Heuslein et al, which published online ahead of print on September 3, 2015 (DOI: 10.1161/ATVBAHA.115.305775), a correction was needed. Brett R. Blackman was added as the penultimate author of the article. The article has been corrected for publication in the November 2015 issue. PMID:26490278
29 CFR 1912.11 - Terms of ad hoc committee members.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 29 Labor 7 2010-07-01 2010-07-01 false Terms of ad hoc committee members. 1912.11 Section 1912.11..., DEPARTMENT OF LABOR (CONTINUED) ADVISORY COMMITTEES ON STANDARDS Organizational Matters § 1912.11 Terms of ad hoc committee members. Each member of an ad hoc advisory committee shall serve for such period as...
29 CFR 1912.11 - Terms of ad hoc committee members.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 29 Labor 7 2013-07-01 2013-07-01 false Terms of ad hoc committee members. 1912.11 Section 1912.11..., DEPARTMENT OF LABOR (CONTINUED) ADVISORY COMMITTEES ON STANDARDS Organizational Matters § 1912.11 Terms of ad hoc committee members. Each member of an ad hoc advisory committee shall serve for such period as...
29 CFR 1912.11 - Terms of ad hoc committee members.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 29 Labor 7 2012-07-01 2012-07-01 false Terms of ad hoc committee members. 1912.11 Section 1912.11..., DEPARTMENT OF LABOR (CONTINUED) ADVISORY COMMITTEES ON STANDARDS Organizational Matters § 1912.11 Terms of ad hoc committee members. Each member of an ad hoc advisory committee shall serve for such period as...
29 CFR 1912.11 - Terms of ad hoc committee members.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 29 Labor 7 2014-07-01 2014-07-01 false Terms of ad hoc committee members. 1912.11 Section 1912.11..., DEPARTMENT OF LABOR (CONTINUED) ADVISORY COMMITTEES ON STANDARDS Organizational Matters § 1912.11 Terms of ad hoc committee members. Each member of an ad hoc advisory committee shall serve for such period as...
29 CFR 1912.11 - Terms of ad hoc committee members.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 29 Labor 7 2011-07-01 2011-07-01 false Terms of ad hoc committee members. 1912.11 Section 1912.11..., DEPARTMENT OF LABOR (CONTINUED) ADVISORY COMMITTEES ON STANDARDS Organizational Matters § 1912.11 Terms of ad hoc committee members. Each member of an ad hoc advisory committee shall serve for such period as...
Improved Correction of IR Loss in Diffuse Shortwave Measurements: An ARM Value-Added Product
Younkin, K; Long, CN
2003-11-01
Simple single black detector pyranometers, such as the Eppley Precision Spectral Pyranometer (PSP) used by the Atmospheric Radiation Measurement (ARM) Program, are known to lose energy via infrared (IR) emission to the sky. This is especially a problem when making clear-sky diffuse shortwave (SW) measurements, which are inherently of low magnitude and suffer the greatest IR loss. Dutton et al. (2001) proposed a technique using information from collocated pyrgeometers to help compensate for this IR loss. The technique uses an empirically derived relationship between the pyrgeometer detector data (and alternatively the detector data plus the difference between the pyrgeometer case and dome temperatures) and the nighttime pyranometer IR loss data. This relationship is then used to apply a correction to the diffuse SW data during daylight hours. We developed an ARM value-added product (VAP) called the SW DIFF CORR 1DUTT VAP to apply the Dutton et al. correction technique to ARM PSP diffuse SW measurements.
Correcting Radial Velocities for Long-Term Magnetic Activity Variations.
Saar; Fischer
2000-05-01
We study stars in the Lick planetary survey for correlations between simultaneous measurements of high-precision radial velocities vr and magnetic activity (as measured in an SIR emission index from Ca ii lambda8662). We find significant correlations in approximately 30% of the stars. After removing linear trends between SIR and vr, we find that the dispersion in vr in these stars is decreased by an average of 17%, or approximately 45% of the dispersion above the measurement noise. F stars and less active stars with variable Ca ii H and K lines are the most successfully corrected. The magnitude of the slope of the SIR versus vr relations increases proportional to vsini and (excepting M dwarfs) tends to decrease with decreasing Teff. We argue that the main cause of these effects is modification of the mean line bisector shape brought on by long-term, magnetic activity-induced changes in the surface brightness and convective patterns. The correlations can be used to partially correct vr data for the effects of long-term activity variations, potentially permitting study of planets around some (higher mass) younger stars and planets producing smaller stellar reflex velocities. PMID:10790082
2015-12-01
In the article by Narayan et al (Narayan O, Davies JE, Hughes AD, Dart AM, Parker KH, Reid C, Cameron JD. Central aortic reservoir-wave analysis improves prediction of cardiovascular events in elderly hypertensives. Hypertension. 2015;65:629–635. doi: 10.1161/HYPERTENSIONAHA.114.04824), which published online ahead of print December 22, 2014, and appeared in the March 2015 issue of the journal, some corrections were needed.On page 632, Figure, panel A, the label PRI has been corrected to read RPI. In panel B, the text by the upward arrow, "10% increase in kd,” has been corrected to read, "10% decrease in kd." The corrected figure is shown below.The authors apologize for these errors. PMID:26558821
Quantum strings in AdS5 × S5: strong-coupling corrections to dimension of Konishi operator
NASA Astrophysics Data System (ADS)
Roiban, R.; Tseytlin, A. A.
2009-11-01
We consider leading strong coupling corrections to the energy of the lightest massive string modes in \\adss, which should be dual to members of the Konishi operator multiplet in Script N = 4 SYM theory. This determines the general structure of the strong-coupling expansion of the anomalous dimension of the Konishi operator. We use 1-loop results for several semiclassical string states to extract information about the leading coefficients in this expansion. Our prediction is Δ = 2λ1/4+b0+b1λ-1/4+b3λ-3/4+..., where b0 and b1 are rational while b3 is transcendental (containing ζ(3)). Explicitly, we argue that b0 = Δ0-4 (where Δ0 is the canonical dimension of the corresponding gauge-theory operator in the Konishi multiplet) and b1 = 1. Our conclusions are sensitive to few assumptions, implied by a correspondence with flat-space expressions, on how to translate semiclassical quantization results into predictions for the exact quantum string spectrum.
76 FR 6162 - Notice of Federal Long-Term Care Insurance Program Open Season; Correction
Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-03
... MANAGEMENT Notice of Federal Long-Term Care Insurance Program Open Season; Correction AGENCY: U.S. Office of... a correction to the notice published in the Federal Register of January 28, 2011 (76 FR 5222). The...-606-0004. Correction In the Federal Register of January 28, 2011, in FR Doc. 2011-1852, on page...
Proton Radius, Darwin-Foldy Term and Radiative Corrections
NASA Astrophysics Data System (ADS)
Jentschura, Ulrich
2013-04-01
It is not an easy task to define the proton charge radius. Namely, by definition, the proton radius is the slope of the GESachs form factor of the proton at zero momentum transfer, provided one has subtracted from the scattering cross sections, all effects due to QED. That means that radiative corrections must be subtracted; these otherwise ``mask'' the proton structure from the surroundings. On the other hand, the self-energy of the proton (not of the electron or of the muon) also influence the spectrum of atomic hydrogen, or muonic hydrogen, respectively. In the talk, we shall review the difficulties faced by a consistent definition, offer a way to resolve them, and review the current status of Lamb shift predictions in muonic hydrogen, with a special reference to the current experimental-theoretical discrepancy, as reported by the CREMA collaboration.
Kashani, Alireza G; Olsen, Michael J; Parrish, Christopher E; Wilson, Nicholas
2015-01-01
In addition to precise 3D coordinates, most light detection and ranging (LIDAR) systems also record "intensity", loosely defined as the strength of the backscattered echo for each measured point. To date, LIDAR intensity data have proven beneficial in a wide range of applications because they are related to surface parameters, such as reflectance. While numerous procedures have been introduced in the scientific literature, and even commercial software, to enhance the utility of intensity data through a variety of "normalization", "correction", or "calibration" techniques, the current situation is complicated by a lack of standardization, as well as confusing, inconsistent use of terminology. In this paper, we first provide an overview of basic principles of LIDAR intensity measurements and applications utilizing intensity information from terrestrial, airborne topographic, and airborne bathymetric LIDAR. Next, we review effective parameters on intensity measurements, basic theory, and current intensity processing methods. We define terminology adopted from the most commonly-used conventions based on a review of current literature. Finally, we identify topics in need of further research. Ultimately, the presented information helps lay the foundation for future standards and specifications for LIDAR radiometric calibration. PMID:26561813
NASA Astrophysics Data System (ADS)
Casanueva, A.; Kotlarski, S.; Herrera, S.; Fernández, J.; Gutiérrez, J. M.; Boberg, F.; Colette, A.; Christensen, O. B.; Goergen, K.; Jacob, D.; Keuler, K.; Nikulin, G.; Teichmann, C.; Vautard, R.
2015-10-01
correcting some distributional features typically leads to an improvement of some aspects but to a deterioration of others. Regarding mean seasonal biases before the BC, we find only limited evidence for an added value of the higher resolution in the precipitation intensity and frequency or in the derived indicators. Thereby, evaluation results considerably depend on the RCM, season and indicator considered. High resolution simulations better reproduce the indicators' spatial patterns, especially in terms of spatial correlation. However, this improvement is not statistically significant after applying specific BC methods.
NASA Astrophysics Data System (ADS)
Casanueva, A.; Kotlarski, S.; Herrera, S.; Fernández, J.; Gutiérrez, J. M.; Boberg, F.; Colette, A.; Christensen, O. B.; Goergen, K.; Jacob, D.; Keuler, K.; Nikulin, G.; Teichmann, C.; Vautard, R.
2016-08-01
correcting some distributional features typically leads to an improvement of some aspects but to a deterioration of others. Regarding mean seasonal biases before the BC, we find only limited evidence for an added value of the higher resolution in the precipitation intensity and frequency or in the derived indicators. Thereby, evaluation results considerably depend on the RCM, season and indicator considered. High resolution simulations better reproduce the indicators' spatial patterns, especially in terms of spatial correlation. However, this improvement is not statistically significant after applying specific BC methods.
Long-Term Fluctuations in the Earth's Rotation: 700 BC to AD 1990
NASA Astrophysics Data System (ADS)
Stephenson, F. R.; Morrison, L. V.
1995-04-01
Records of solar and lunar eclipses in the period 700 BC to AD 1600, originating from the ancient and medieval civilizations of Babylon, China, Europe and the Arab world, are amassed and critically appraised for their usefulness in answering questions about the long-term variability of the Earth's rate of rotation. Results from previous analyses of lunar occultations in the period AD 1600-1955.5, and from high-precision data in AD 1955.5-1990, are included in the dataset considered in this paper. Using the change in the length of the mean solar day (l.o.d.) in units of milliseconds per century (ms cy-1) as the measure of acceleration in the rate of rotation, it is found that the l.o.d. has increased by (+1.70 ± 0.05) ms cy-1 (equiv (-4.5 ± 0.1) × 10-22 rad s-2) on average over the past 2700 years. Yet an increase of +2.3 ± 0.1 ms cy-1 (equiv (-6.1 ± 0.4) × 10-22 rad s-2) is expected from the tidal braking of the Earth's spin, assuming a value of -26.0' ' cy-2 for the tidal acceleration of the Moon. There is thus an average accelerative component in the Earth's rotation which acts to decrease the l.o.d. by (-0.6 ± 0.1) ms cy-1 (equiv (+1.6 ± 0.4) × 10-22 rad s-2). Moreover, it is shown that besides this accelerative component, there is a fluctuation in the l.o.d. with a semi-amplitude of ~ 4 ms and a period of ~ 1500 yr.
Schoen, K.; Snow, W. M.; Kaiser, H.; Werner, S. A.
2005-01-01
The neutron index of refraction is generally derived theoretically in the Fermi approximation. However, the Fermi approximation neglects the effects of the binding of the nuclei of a material as well as multiple scattering. Calculations by Nowak introduced correction terms to the neutron index of refraction that are quadratic in the scattering length and of order 10−3 fm for hydrogen and deuterium. These correction terms produce a small shift in the final value for the coherent scattering length of H2 in a recent neutron interferometry experiment. PMID:27308132
NASA Technical Reports Server (NTRS)
Malu, M.; Tien, J. K.
1975-01-01
The effect of elastic modulus and the temperature dependence of elastic modulus on creep activation energies for an oxide dispersion strengthened nickel-base superalloy are investigated. This superalloy is commercially known as Inconel Alloy MA 753, strengthened both by gamma-prime precipitates and by yttria particles. It is shown that at intermediate temperatures, say below 1500 F, where elastic modulus is weakly dependent on temperature, the modulus correction term to creep activation energy is small. Accordingly, modulus corrections are insignificant for the superalloy considered, which shows high apparent creep activation energies at this temperature. On the contrary, at very high temperatures, the elastic modulus correction term can be significant, thus reducing the creep activation energy to that of vacancy self-diffusion. In order to obtain high-temperature creep resistance, a high-value elastic modulus with a weak dependence on temperature is required.
Many observations of temperature and wind speed profiles have been taken over "ideal" terrain and analyzed to develop the stability correction terms which are commonly used in the application of similarity theory. Fewer observations have been taken and analyzed in this manner ov...
NASA Astrophysics Data System (ADS)
1995-04-01
Seismic images of the Brooks Range, Arctic Alaska, reveal crustal-scale duplexing: Correction Geology, v. 23, p. 65 68 (January 1995) The correct Figure 4A, for the loose insert, is given here. See Figure 4A below. Corrected inserts will be available to those requesting copies of the article from the senior author, Gary S. Fuis, U.S. Geological Survey, 345 Middlefield Road, Menlo Park, CA 94025. Figure 4A. P-wave velocity model of Brooks Range region (thin gray contours) with migrated wide-angle reflections (heavy red lines) and migreated vertical-incidence reflections (short black lines) superimposed. Velocity contour interval is 0.25 km/s; 4,5, and 6 km/s contours are labeled. Estimated error in velocities is one contour interval. Symbols on faults shown at top are as in Figure 2 caption.
MEASUREMENT AND CORRECTION OF THIRD RESONANCE DRIVING TERM IN THE RHIC
LUO,Y.; BAI, M.; BENGTSSON, J.; CALAGA, R.; FISCHER, W.; ET AL.
2007-06-25
To further improve the luminosity in polarized proton operation of the Relativistic Heavy Ion Collider, correction of the horizontal two-third resonance at store is desirable. The long-lasting coherent beam oscillations, produced by the AC dipole, are used to measure 3Q,'s resonance driving term h{sub 30000} through the analysis of turn-by-turn beam position data with the algorithm outlined by J. Bengtsson. The resonance driving term h30000 can be compensated with the 12 arc chromatic sextupole families. In this article, we will review the technique of h{sub 30000} resonance driving term's measurement and correction with AC dipole excitation in the RHIC, followed by the preliminary beam experiment results from the RHIC 2006 polarized proton run.
2016-02-01
Neogi T, Jansen TLTA, Dalbeth N, et al. 2015 Gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 2015;74:1789–98. The name of the 20th author was misspelled. The correct spelling is Janitzia Vazquez-Mellado. We regret the error. PMID:26881284
AdS orbifolds and Penrose limits
Alishahiha, Mohsen; Sheikh-Jabbari, Mohammad M.; Tatar, Radu
2002-12-09
In this paper we study the Penrose limit of AdS{sub 5} orbifolds. The orbifold can be either in the pure spatial directions or space and time directions. For the AdS{sub 5}/{Lambda} x S{sup 5} spatial orbifold we observe that after the Penrose limit we obtain the same result as the Penrose limit of AdS{sub 5} x S{sup 5}/{Lambda}. We identify the corresponding BMN operators in terms of operators of the gauge theory on R x S{sup 3}/{Lambda}. The semi-classical description of rotating strings in these backgrounds have also been studied. For the spatial AdS orbifold we show that in the quadratic order the obtained action for the fluctuations is the same as that in S{sup 5} orbifold, however, the higher loop correction can distinguish between two cases.
2016-02-01
In the article by Guessous et al (Guessous I, Pruijm M, Ponte B, Ackermann D, Ehret G, Ansermot N, Vuistiner P, Staessen J, Gu Y, Paccaud F, Mohaupt M, Vogt B, Pechère-Bertschi A, Martin PY, Burnier M, Eap CB, Bochud M. Associations of ambulatory blood pressure with urinary caffeine and caffeine metabolite excretions. Hypertension. 2015;65:691–696. doi: 10.1161/HYPERTENSIONAHA.114.04512), which published online ahead of print December 8, 2014, and appeared in the March 2015 issue of the journal, a correction was needed.One of the author surnames was misspelled. Antoinette Pechère-Berstchi has been corrected to read Antoinette Pechère-Bertschi.The authors apologize for this error. PMID:26763012
Long-term variations in natural, terrestrial VOC emissions: 1000-1990 AD
NASA Astrophysics Data System (ADS)
Acosta, J. C.; Struthers, H.; Zorita, E.; Ekman, A. M.; Riipinen, I.
2012-12-01
). We evaluate the long-term response of terrestrial BVOC emission activity to variations in land-use change and climatic factors, and find that compared to preindustrial times (1000-1800 A.D.), global isoprene emissions have decreased 8%, monoterpenes emissions have increased 10% and sesquiterpenes emissions have increased 15% during the time period 1950-1990 A.D.. The results suggest that the variation of isoprene emissions is governed by land-use changes, while monoterpenenes and sesquiterpenes variations are dominated by climate variability. Adams, J.M. (2001). Chemosphere - Global Change Science, 3, 73-91 J.H. Seinfeld and S. N. Pandis. (1998). Atmospheric Chemistry and Physics . Wiley, New York Jimenez, J. L. et al. (2009). Science, 326, 1525-1529 Kaplan, J. O. et al (2010). The Holocene 21(5), 775-791 Guenther, A. et al. (1995). J. Geophys. Res., 100, 8873-8892 Hoyle, C. R. et al. (2011). Atmos. Chem. Phys., 11, 321-343 A. Guenther et al. (2006). Atmospheric Chemistry and Physics, 6:3181-3210 J. H. Jungclaus et al. (2010). Climate of the Past, 6:723-737
Long-term surgical versus functional Class II correction: a comparison of identical twins.
Chhibber, Aditya; Upadhyay, Madhur; Uribe, Flavio; Nanda, Ravindra
2015-01-01
The purpose of this twin case comparison was to assess the short- and long-term effects of nonsurgical treatment vs orthognathic surgical treatment for Class II correction. Two identical twins (age 13 years 3 months) were treated for Class II correction where one patient was treated nonsurgically using a fixed functional appliance, while the other was treated using orthognathic mandibular advancement surgery. The patients were recalled and evaluated 5 years in retention. Comparing changes in the short and long term, surgical treatment led to superior skeletal results compared to the nonsurgical twin. However, the soft tissue profile was remarkably similar for both patients suggesting that soft tissue profile changes may not necessarily follow similar changes in the bony skeletal structures. PMID:25075777
Correction terms for propagators and d’Alembertians due to spacetime discreteness
NASA Astrophysics Data System (ADS)
Johnston, Steven
2015-10-01
The causal set approach to quantum gravity models spacetime as a discrete structure—a causal set. Recent research has led to causal set models for the retarded propagator for the Klein-Gordon equation and the d’Alembertian operator. These models can be compared to their continuum counterparts via a sprinkling process. It has been shown that the models agree exactly with the continuum quantities in the limit of an infinite sprinkling density—the continuum limit. This paper obtains the correction terms for these models for sprinkled causal sets with a finite sprinkling density. These correction terms are an important step towards testable differences between the continuum and discrete models that could provide evidence of spacetime discreteness.
Long-term complications after surgical correction of Laubry-Pezzi syndrome
Sbizzera, Marc; Cosset, Benoit; Koffel, Catherine; Obadia, Jean François; Robin, Jacques
2016-01-01
Laubry-Pezzi syndrome is a rare congenital heart disease (CHD) combining a ventricular septal defect (VSD) and an aortic regurgitation (AR) due to a prolapse of the right coronary or, less frequently, non-coronary cusp. In the literature there are very few reports of long-term complications after surgical correction of this syndrome. We present the late occurrence of an aortic root pseudoaneurysm and a residual VSD in a patient with Laubry-Pezzi syndrome operated during childhood. PMID:27076977
ON THE LINEAR TERM CORRECTION FOR NEEDLET/WAVELET NON-GAUSSIANITY ESTIMATORS
Donzelli, Simona; Hansen, Frode K.; Liguori, Michele; Matarrese, Sabino; Marinucci, Domenico
2012-08-10
We derive the linear correction term for needlet and wavelet estimators of the bispectrum and the nonlinearity parameter f{sub NL} on cosmic microwave background radiation data. We show that on masked WMAP-like data with anisotropic noise, the error bars improve by 10%-20% and almost reach the optimal error bars obtained with the bispectrum estimator also known as 'KSW'. In the limit of full-sky and isotropic noise, this term vanishes. We apply needlet and wavelet estimators to the WMAP 7-year data and obtain our best estimate f{sub NL} = 37.5 {+-} 21.8 (68% CL).
Smooth particle hydrodynamics: importance of correction terms in adaptive resolution algorithms
NASA Astrophysics Data System (ADS)
Alimi, J.-M.; Serna, A.; Pastor, C.; Bernabeu, G.
2003-11-01
We describe TREEASPH, a new code to evolve self-gravitating fluids, both with and without a collisionless component. In TREEASPH, gravitational forces are computed from a hierarchical tree algorithm (TREEcode), while hydrodynamic properties are computed by using a SPH method that includes the ∇h correction terms appearing when the spatial resolution h(t,r) is not a constant. Another important feature, which considerably increases the code efficiency on sequential and vectorial computers, is that time-stepping is performed from a PEC scheme (Predict-Evaluate-Correct) modified to allow for individual timesteps. Some authors have previously noted that the ∇h correction terms are needed to avoid the introduction on simulations of a non-physical entropy. By using TREEASPH we show here that, in cosmological simulations, this non-physical entropy has a negative sign. As a consequence, when the ∇h terms are neglected, the density peaks associated to shock fronts are overestimated. This in turn results in an overestimated efficiency of star-formation processes.
2015-05-22
The Circulation Research article by Keith and Bolli (“String Theory” of c-kitpos Cardiac Cells: A New Paradigm Regarding the Nature of These Cells That May Reconcile Apparently Discrepant Results. Circ Res. 2015:116:1216-1230. doi: 10.1161/CIRCRESAHA.116.305557) states that van Berlo et al (2014) observed that large numbers of fibroblasts and adventitial cells, some smooth muscle and endothelial cells, and rare cardiomyocytes originated from c-kit positive progenitors. However, van Berlo et al reported that only occasional fibroblasts and adventitial cells derived from c-kit positive progenitors in their studies. Accordingly, the review has been corrected to indicate that van Berlo et al (2014) observed that large numbers of endothelial cells, with some smooth muscle cells and fibroblasts, and more rarely cardiomyocytes, originated from c-kit positive progenitors in their murine model. The authors apologize for this error, and the error has been noted and corrected in the online version of the article, which is available at http://circres.ahajournals.org/content/116/7/1216.full ( PMID:25999426
NASA Astrophysics Data System (ADS)
1998-12-01
Alleged mosasaur bite marks on Late Cretaceous ammonites are limpet (patellogastropod) home scars Geology, v. 26, p. 947 950 (October 1998) This article had the following printing errors: p. 947, Abstract, line 11, “sepia” should be “septa” p. 947, 1st paragraph under Introduction, line 2, “creep” should be “deep” p. 948, column 1, 2nd paragraph, line 7, “creep” should be “deep” p. 949, column 1, 1st paragraph, line 1, “creep” should be “deep” p. 949, column 1, 1st paragraph, line 5, “19774” should be “1977)” p. 949, column 1, 4th paragraph, line 7, “in particular” should be “In particular” CORRECTION Mammalian community response to the latest Paleocene thermal maximum: An isotaphonomic study in the northern Bighorn Basin, Wyoming Geology, v. 26, p. 1011 1014 (November 1998) An error appeared in the References Cited. The correct reference appears below: Fricke, H. C., Clyde, W. C., O'Neil, J. R., and Gingerich, P. D., 1998, Evidence for rapid climate change in North America during the latest Paleocene thermal maximum: Oxygen isotope compositions of biogenic phosphate from the Bighorn Basin (Wyoming): Earth and Planetary Science Letters, v. 160, p. 193 208.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Formal requirements for application for extension of patent term; correction of informalities. 1.740 Section 1.740 Patents, Trademarks... Review § 1.740 Formal requirements for application for extension of patent term; correction...
Code of Federal Regulations, 2014 CFR
2014-07-01
... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Formal requirements for application for extension of patent term; correction of informalities. 1.740 Section 1.740 Patents, Trademarks... Review § 1.740 Formal requirements for application for extension of patent term; correction...
Li, Chao; Ding, Lei; Sun, Chiao-Wang; Wu, Li-Chen; Zhou, Dewang; Pawlik, Kevin M.; Khodadadi-Jamayran, Alireza; Westin, Erik; Goldman, Frederick D.; Townes, Tim M.
2016-01-01
CRISPR/Cas enhanced correction of the sickle cell disease (SCD) genetic defect in patient-specific induced Pluripotent Stem Cells (iPSCs) provides a potential gene therapy for this debilitating disease. An advantage of this approach is that corrected iPSCs that are free of off-target modifications can be identified before differentiating the cells into hematopoietic progenitors for transplantation. In order for this approach to be practical, iPSC generation must be rapid and efficient. Therefore, we developed a novel helper-dependent adenovirus/Epstein-Barr virus (HDAd/EBV) hybrid reprogramming vector, rCLAE-R6, that delivers six reprogramming factors episomally. HDAd/EBV transduction of keratinocytes from SCD patients resulted in footprint-free iPSCs with high efficiency. Subsequently, the sickle mutation was corrected by delivering CRISPR/Cas9 with adenovirus followed by nucleoporation with a 70 nt single-stranded oligodeoxynucleotide (ssODN) correction template. Correction efficiencies of up to 67.9% (βA/[βS+βA]) were obtained. Whole-genome sequencing (WGS) of corrected iPSC lines demonstrated no CRISPR/Cas modifications in 1467 potential off-target sites and no modifications in tumor suppressor genes or other genes associated with pathologies. These results demonstrate that adenoviral delivery of reprogramming factors and CRISPR/Cas provides a rapid and efficient method of deriving gene-corrected, patient-specific iPSCs for therapeutic applications. PMID:27460639
Li, Chao; Ding, Lei; Sun, Chiao-Wang; Wu, Li-Chen; Zhou, Dewang; Pawlik, Kevin M; Khodadadi-Jamayran, Alireza; Westin, Erik; Goldman, Frederick D; Townes, Tim M
2016-01-01
CRISPR/Cas enhanced correction of the sickle cell disease (SCD) genetic defect in patient-specific induced Pluripotent Stem Cells (iPSCs) provides a potential gene therapy for this debilitating disease. An advantage of this approach is that corrected iPSCs that are free of off-target modifications can be identified before differentiating the cells into hematopoietic progenitors for transplantation. In order for this approach to be practical, iPSC generation must be rapid and efficient. Therefore, we developed a novel helper-dependent adenovirus/Epstein-Barr virus (HDAd/EBV) hybrid reprogramming vector, rCLAE-R6, that delivers six reprogramming factors episomally. HDAd/EBV transduction of keratinocytes from SCD patients resulted in footprint-free iPSCs with high efficiency. Subsequently, the sickle mutation was corrected by delivering CRISPR/Cas9 with adenovirus followed by nucleoporation with a 70 nt single-stranded oligodeoxynucleotide (ssODN) correction template. Correction efficiencies of up to 67.9% (β(A)/[β(S)+β(A)]) were obtained. Whole-genome sequencing (WGS) of corrected iPSC lines demonstrated no CRISPR/Cas modifications in 1467 potential off-target sites and no modifications in tumor suppressor genes or other genes associated with pathologies. These results demonstrate that adenoviral delivery of reprogramming factors and CRISPR/Cas provides a rapid and efficient method of deriving gene-corrected, patient-specific iPSCs for therapeutic applications. PMID:27460639
Nutation model (IAU 1980) and the corrections of its main terms from BLZ and PIP data.
NASA Astrophysics Data System (ADS)
Damljanović, G.; de Biasi, M. S.
The star observations of the Belgrade visual zenith telescope (in the list of Bureau International de l'Heure (BIH) series denoted by BLZ) for the period 1960 - 1985 (about 26 years of latitude data) and the Punta Indio photographic zenith tube (denoted by PIP) for the period 1971 - 1984 (about 14 years of latitude data) were used to obtain the correction (ΔN) to the amplitude of long periodic 18.6 years nutation obliquity term. The least-square method (LSQ) was applied. The reduction of both BLZ and PIP data was in line with the IAU 1980 Nutation Model.
NASA Astrophysics Data System (ADS)
Gómez, Sergio S.; Melo, Juan I.; Romero, Rodolfo H.; Aucar, Gustavo A.; de Azúa, Martín Ruiz
2005-02-01
We have calculated the relativistic corrections to the diamagnetic term of the nuclear magnetic shielding constants for a series of molecules containing heavy atoms. An analysis of the contributions from localized orbitals is performed. We establish quantitatively the relative importance of inner core and valence shell molecular orbitals in each correcting term. Contributions from the latter are much less important than those from the former. The calculated values of the correction σL-PSO, first derived within the linear response elimination of small component formalism, show a power-law dependence on the nuclear charge ˜Z3.5, in contrast with the ˜Z3.1 behavior of the mass-velocity external-field correction to the paramagnetic term previously reported.
Tsoucalas, Gregory; Sgantzos, Markos
2016-09-01
The eminent Greek physician Paul of Aegina, native of the Saronic island Aegina and pupil of the Alexandrian School, understood both exotropia and endotropia, his designation for esotropia and proposed therapeutic measures for their treatment during baby or toddler age. He had introduced an innovative method for the newborns to have a straight vision, "the congenital strabismus of the newborns must be treated with the placement of a facial mask (with 2 open holes in the middle axes of the eyes), so that the babies could only see in a straight line", combined with a small oil lamp to assure a direct eye alignment. Although not even a diagram of the masks was saved until nowadays, Paul was the first to suggest the early correction of the eyes deviation, and considered to be the father of orthoptics. PMID:27593906
NASA Astrophysics Data System (ADS)
Bumberger, Jan; Mollenhauer, Hannes; Lapteva, Yulia; Hutschenreuther, Tino; Toepfer, Hannes; Dietrich, Peter
2014-05-01
To characterize environmental systems it is necessary to identify and describe processes with suitable methods. Environmental systems are often characterized by their high heterogeneity, so individual measurements for their complete representation are often not sufficient. The application of wireless sensor networks in terrestrial and aquatic ecosystems offer significant benefits as a better consideration of the local test conditions becomes possible. This can be essential for the monitoring of heterogeneous environmental systems. Significant advantages in the application of mobile ad-hoc wireless sensor networks are their self-organizing behavior, resulting in a major reduction in installation and operation costs and time. In addition, a point measurement with a sensor is significantly improved by measuring at several points. It is also possible to perform analog and digital signal processing and computation on the basis of the measured data close to the sensor. Hence, a significant reduction of the data to be transmitted can be achieved which leads to a better energy management of sensor nodes. Furthermore, their localization via satellite, the miniaturization of the nodes and long-term energy self-sufficiency are current topics under investigation. The possibilities and limitations of the applicability of wireless sensor networks for long-term and mobile environmental monitoring are presented. A concepts and realization example are given in the field of micrometeorology and soil parameters for the interaction of biotic and abiotic processes .This long term monitoring is part of the Global Change Experimental Facility (GCEF), a large field-based experimental platform to assess the effects of climate change on ecosystem functions and processes under different land-use scenarios. Furthermore a mobile ad-hoc sensor network is presented for the monitoring of water induced mass wasting processes.
ERIC Educational Resources Information Center
Raudenbush, Stephen W.
2014-01-01
Proposals to evaluate teachers based on their "value-added" to student test scores generate intense debate. Underlying the debate are concerns about three factors: "bias," "precision," and "relevance." Previous Carnegie Foundation briefs have detailed the reasons why the first two are significant concerns.…
Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice.
Baglietto-Vargas, David; Chen, Yuncai; Suh, Dongjin; Ager, Rahasson R; Rodriguez-Ortiz, Carlos J; Medeiros, Rodrigo; Myczek, Kristoffer; Green, Kim N; Baram, Tallie Z; LaFerla, Frank M
2015-09-01
Alzheimer's disease (AD) is a progressive neurological disorder that impairs memory and other cognitive functions in the elderly. The social and financial impacts of AD are overwhelming and are escalating exponentially as a result of population aging. Therefore, identifying AD-related risk factors and the development of more efficacious therapeutic approaches are critical to cure this neurological disorder. Current epidemiological evidence indicates that life experiences, including chronic stress, are a risk for AD. However, it is unknown if short-term stress, lasting for hours, influences the onset or progression of AD. Here, we determined the effect of short-term, multi-modal 'modern life-like' stress on AD pathogenesis and synaptic plasticity in mice bearing three AD mutations (the 3xTg-AD mouse model). We found that combined emotional and physical stress lasting 5 h severely impaired memory in wild-type mice and tended to impact it in already low-performing 3xTg-AD mice. This stress reduced the number of synapse-bearing dendritic spines in 3xTg-AD mice and increased Aβ levels by augmenting AβPP processing. Thus, short-term stress simulating modern-life conditions may exacerbate cognitive deficits in preclinical AD by accelerating amyloid pathology and reducing synapse numbers. Epidemiological evidence indicates that life experiences, including chronic stress, are a risk for Alzheimer disease (AD). However, it is unknown if short stress in the range of hours influences the onset or progression of AD. Here, we determined the effect of short, multi-modal 'modern-lifelike'stress on AD pathogenesis and synaptic plasticity in mice bearing three AD mutations (the 3xTg-AD mouse model). We found that combined emotional and physical stress lasting 5 h severely impaired memory in wild-type mice and tended to impact it in already low-performing 3xTg-AD mice. This stress reduced the number of synapse-bearing dendritic spines in 3xTg-AD mice and increased Aβ levels by
ERIC Educational Resources Information Center
Chetty, Raj; Friedman, John N.; Rockoff, Jonah E.
2011-01-01
Are teachers' impacts on students' test scores ("value-added") a good measure of their quality? This question has sparked debate largely because of disagreement about (1) whether value-added (VA) provides unbiased estimates of teachers' impacts on student achievement and (2) whether high-VA teachers improve students' long-term outcomes.…
ERIC Educational Resources Information Center
Chetty, Raj; Friedman, John N.; Rockoff, Jonah E.
2011-01-01
Are teachers' impacts on students' test scores ("value-added") a good measure of their quality? This question has sparked debate largely because of disagreement about (1) whether value-added (VA) provides unbiased estimates of teachers' impacts on student achievement and (2) whether high-VA teachers improve students' long-term outcomes. We address…
NASA Astrophysics Data System (ADS)
Günther, Uwe; Zhuk, Alexander; Bezerra, Valdir B.; Romero, Carlos
2005-08-01
We study multi-dimensional gravitational models with scalar curvature nonlinearities of types R-1 and R4. It is assumed that the corresponding higher dimensional spacetime manifolds undergo a spontaneous compactification to manifolds with a warped product structure. Special attention has been paid to the stability of the extra-dimensional factor spaces. It is shown that for certain parameter regions the systems allow for a freezing stabilization of these spaces. In particular, we find for the R-1 model that configurations with stabilized extra dimensions do not provide a late-time acceleration (they are AdS), whereas the solution branch which allows for accelerated expansion (the dS branch) is incompatible with stabilized factor spaces. In the case of the R4 model, we obtain that the stability region in parameter space depends on the total dimension D = dim(M) of the higher dimensional spacetime M. For D > 8 the stability region consists of a single (absolutely stable) sector which is shielded from a conformal singularity (and an antigravity sector beyond it) by a potential barrier of infinite height and width. This sector is smoothly connected with the stability region of a curvature-linear model. For D < 8 an additional (metastable) sector exists which is separated from the conformal singularity by a potential barrier of finite height and width so that systems in this sector are prone to collapse into the conformal singularity. This second sector is not smoothly connected with the first (absolutely stable) one. Several limiting cases and the possibility of inflation are discussed for the R4 model.
Adaptive Wireless Ad-hoc Sensor Networks for Long-term and Event-oriented Environmental Monitoring
NASA Astrophysics Data System (ADS)
Bumberger, Jan; Mollenhauer, Hannes; Remmler, Paul; Schaedler, Martin; Schima, Robert; Mollenhauer, Olaf; Hutschenreuther, Tino; Toepfer, Hannes; Dietrich, Peter
2015-04-01
Ecosystems are often characterized by their high heterogeneity, complexity and dynamic. Hence, single point measurements are often not sufficient for their complete representation. The application of wireless sensor networks in terrestrial and aquatic environmental systems offer significant benefits as a better consideration to the local test conditions, due to the simple adjustment of the sensor distribution, the sensor types and the sample rate. Another advantage of wireless ad-hoc sensor networks is their self-organizing behavior, resulting in a major reduction in installation and operation costs and time. In addition, individual point measurements with a sensor are significantly improved by measuring at several points continuously. In this work a concept and realization for Long-term ecosystem research is given in the field monitoring of micrometeorology and soil parameters for the interaction of biotic and abiotic processes. This long term analyses are part of the Global Change Experimental Facility (GCEF), a large field-based experimental platform to assess the effects of climate change on ecosystem functions and processes under different land-use scenarios. Regarding to the adaptive behavior of the network, also a mobile version was developed to overcome the lack of information of temporally and spatially fixed measurements for the detection and recording of highly dynamic or time limited processes. First results of different field campaigns are given to present the potentials and limitations of this application in environmental science, especially for the monitoring of the interaction of biotic and abiotic processes, soil-atmosphere interaction and the validation of remote sensing data.
Adaptive Wireless Ad-hoc Sensor Networks for Long-term and Event-oriented Environmental Monitoring
NASA Astrophysics Data System (ADS)
Bumberger, Jan; Mollenhauer, Hannes; Remmler, Paul; Chirila, Andrei Marian; Mollenhauer, Olaf; Hutschenreuther, Tino; Toepfer, Hannes; Dietrich, Peter
2016-04-01
Ecosystems are often characterized by their high heterogeneity, complexity and dynamic. Hence, single point measurements are often not sufficient for their complete representation. The application of wireless sensor networks in terrestrial and aquatic environmental systems offer significant benefits as a better consideration to the local test conditions, due to the simple adjustment of the sensor distribution, the sensor types and the sample rate. Another advantage of wireless ad-hoc sensor networks is their self-organizing behavior, resulting in a major reduction in installation and operation costs and time. In addition, individual point measurements with a sensor are significantly improved by measuring at several points continuously. In this work a concept and realization for Long-term ecosystem research is given in the field monitoring of micrometeorology and soil parameters for the interaction of biotic and abiotic processes. This long term analyses are part of the Global Change Experimental Facility (GCEF), a large field-based experimental platform to assess the effects of climate change on ecosystem functions and processes under different land-use scenarios. Regarding to the adaptive behavior of the network, also a mobile version was developed to overcome the lack of information of temporally and spatially fixed measurements for the detection and recording of highly dynamic or time limited processes. First results of different field campaigns are given to present the potentials and limitations of this application in environmental science, especially for the monitoring of the interaction of biotic and abiotic processes, soil-atmosphere interaction and the validation of remote sensing data.
NASA Astrophysics Data System (ADS)
Luo, Liantong; Katz, Boaz; Dong, Subo
2016-05-01
The double-averaging (DA) approximation is widely employed as the standard technique in studying the secular evolution of the hierarchical three-body system. We show that effects stemmed from the short-time-scale oscillations ignored by DA can accumulate over long time-scales and lead to significant errors in the long-term evolution of the Lidov-Kozai cycles. In particular, the conditions for having an orbital flip, where the inner orbit switches between prograde and retrograde with respect to the outer orbit and the associated extremely high eccentricities during the switch, can be modified significantly. The failure of DA can arise for a relatively strong perturber where the mass of the tertiary is considerable compared to the total mass of the inner binary. This issue can be relevant for astrophysical systems such as stellar triples, planets in stellar binaries, stellar-mass binaries orbiting massive black holes and moons of the planets perturbed by the Sun. We derive analytical equations for the short-term oscillations of the inner orbit to the leading order for all inclinations, eccentricities and mass ratios. Under the test particle approximation, we derive the `corrected double-averaging' (CDA) equations by incorporating the effects of short-term oscillations into the DA. By comparing to N-body integrations, we show that the CDA equations successfully correct most of the errors of the long-term evolution under the DA approximation for a large range of initial conditions. We provide an implementation of CDA that can be directly added to codes employing DA equations.
Long-term summer temperatures variations in the southern French Alps, A.D. 749-2007
NASA Astrophysics Data System (ADS)
Corona, C.; Edouard, J. L.; Guiot, J.; Guibal, F.; Thomas, A.; Saulnier, M.
2009-04-01
With respect to the past millennium and Europe, only a few temperature reconstruction from sensitive composite tree ring width records exist from northern Scandinavia (Briffa et al. 2007; Helama et al. 2005) and the Alps (Büntgen et al. 2005; Nicolussi and Patzelt 2000). Only one, in the Spanish Pyrenees (Büntgen et al. 2008) concerns the Mediterranean region. The purpose of this presentation is a reconstruction of the summer temperatures over the southern French Alps (44-45°N 6°29-7°40E) during the last millennium. This reconstruction, the first regional one centered on this part of the Alps extending prior to 1000 A.D. and extends forward into the twenty-first century (749-2007). It is based on a network of seventeen multi-centennial larch and stone pine unpublished chronologies combining three hundred and fifty three tree-ring width series of living and dry-dead timberline wood (above 2000 m a.s.l.). These series are standardized using an Adaptative Regional Growth Curve (Nicault et al. 2008) allowing the preservation of inter-annual to multi-centennial length variability due to climate. Spatially resolved instrumental measurements (1°x1° Latlong) from the HISTALP dataset (Auer et al. 2007) back to 1800 A.D. reveal strongest growth response to current-year June-August mean temperatures. The proxies are calibrated to instrumental target records by combining an analogue technique, which is able to extend the too short tree-ring series, with an artificial neural network technique for an optimal non-linear calibration including a bootstrap technique for calculating error assessment on the reconstruction. This reconstruction allows the putative "Medieval Warm Period" (MWP) to be described for French Alps and to be compared with 20th-century warming in modeling and attribution studies. The new reconstruction is compared with reconstructions based on historical sources (Pfister et al. 1994), grape ripening (Meier, 2007), speleothems (Mangini et al. 2005
The Short-Term Effects of Individual Corrective Feedback on L2 Pronunciation
ERIC Educational Resources Information Center
Dlaska, Andrea; Krekeler, Christian
2013-01-01
This article investigates the effect of explicit individual corrective feedback (ICF) on L2 pronunciation at the micro-level in order to determine whether ICF needs to complement listening only interventions. To this purpose, the authors carried out a study which investigated the immediate effect of feedback on comprehensibility of controlled…
Global modeling of the ice stripping correction in terms of the ice thickness spherical functions
NASA Astrophysics Data System (ADS)
Tenzer, R.; Hamayun; Vajda, P.; Novak, P.
2009-04-01
We model globally the ice stripping correction using techniques for a spherical harmonic analysis of the gravity field. The discrete data of ice thickness with a 2×2 arc-degree geographical resolution from the global crustal model CRUST 2.0 (http://mahi.ucsd.edu/Gabi/rem.dir/crust/crust2.html) are used to generate the Global Ice Thickness Model coefficients. The 5×5 arc-minute global elevation data from the ETOPO5 (provided by the NOAA's National Geophysical Data Centre) are used to generate the Global Elevation Model coefficients. The ice thickness and elevation spectral coefficients are utilized to compute globally the ice stripping correction with a spectral resolution complete to degree and order 90. The mean value of the ice density contrast -1757 kg/m3 (i.e., the difference between the mean ice density 913 kg/m3 and the reference crustal density 2670 kg/m3) is adopted. The expressions for computing the ice stripping corrections to the gravity field quantities are introduced in spectral domain. The results reveal that the ice stripping correction to the gravity disturbances varies globally between 2 and 300 mGal with the mean of 22 mGal and the standard deviation of 56 mGal. The complete ice stripping correction to the gravity anomalies (which comprises the direct and secondary indirect ice density contrast effects) varies from -53 to 199 mGal with the mean of -1 mGal and the standard deviation of 37 mGal. The gravitational potential generated by the ice density contrast varies from -3498 to -319 m2/s2 with the mean of -743 m2/s2 and the standard deviation of 733 m2/s2.
Lee, Seong-Geun; Kang, Young-Hoon; Byun, June-Ho; Kim, Uk-Kyu; Kim, Jong-Ryoul
2015-01-01
Bilateral sagittal split ramus osteotomy is considered a standard technique in mandibular orthognathic surgeries to reduce unexpected bilateral stress in the temporomandibular joints. Unilateral sagittal split ramus osteotomy (USSO) was recently introduced to correct facial asymmetry caused by asymmetric mandibular prognathism and has shown favorable outcomes. If unilateral surgery could guarantee long-term postoperative stability as well as favorable results, operation time and the incidence of postoperative complications could be reduced compared to those in bilateral surgery. This report highlights three consecutive cases with long-term follow-up in which USSO was used to correct asymmetric mandibular prognathism. Long-term postoperative changes in the condylar contour and ramus and condylar head length were analyzed using routine radiography and computed tomography. In addition, prior USSO studies were reviewed to outline clear criteria for applying this technique. In conclusion, patients showing functional-type asymmetry with predicted unilateral mandibular movement of less than 7 mm can be considered suitable candidates for USSO-based correction of asymmetric mandibular prognathism with or without maxillary arch surgeries. PMID:26131434
NASA Astrophysics Data System (ADS)
Chanzy, André; Chabbi, Abad; Houot, Sabine; Lafolie, François; Pichot, Christian; Raynal, Hélène; Saint-André, Laurent; Clobert, Jean; Greiveldinger, Lucile
2015-04-01
term experiments to implement novel observational systems. Through active collaboration with the teams in charge of the experiments, users will take advantage of the site characterization, historical data, monitoring setup and access to different treatments experimental field with differentiated properties induced by repeated treatment. • Access to soil and vegetation samples collected at different dates that may be reanalyzed a posteriori to take profit of technological progress. • Delivery of reference data on ecosystems subjected to a gradient of anthropogenic and climatic pressures. The research infrastructure level is appropriate to implement a harmonization policy for the measurement and observation protocols. Moreover it offers the possibility of developing an ambitious strategy in integrating data and models. These can contribute to the experimental process for protocol design or data quality control. Moreover, they offer an efficient way for promoting data reuse thus giving a strong added value to the existing data bases. Therefore, building interoperability between models and experimental platform data bases is an important objective to improve the quality of experimental infrastructure and provide users with seamless and integrated information systems. We present how this is operated in AnaEE-France with different tasks as the development of a controlled vocabulary, tools to annotate data and model variables with metadata based on ontologies and the development of webservice to harvest data from the data base to the modelling platform environment. Finally some examples of key results taking profit of the range of experiments are provided.
Simple correction improving long-term reproducibility of HPLC-MS.
Tóth, Eszter; Hevér, Helga; Ozohanics, Olivér; Telekes, András; Vékey, Károly; Drahos, László
2015-10-01
Chromatographic peak areas in long series of high-performance liquid chromatography-MS experiments often vary, which decrease reproducibility and may cause bias in the results. It was found that the sensitivity of various components change differently; in our case, variability is in the order of 20-40%, and it is most likely due to changing conditions in electrospray ionization (ESI). The most often used peak area correction methods do not take this effect into account. The change in peak areas can be well described by a polynomial function; we found that a fourth-order polynomial is most often suitable. We suggest a simple correction algorithm based on polynomial fitting. When the experiments were inherently well reproducible, this correction improved reproducibility from 12% to 3% (on average for various components). When random errors were larger, this improvement was less significant (15% to 12% in nano-ESI) but nevertheless essential in order to avoid possible bias in the results. PMID:26456781
An MRI-Derived Definition of MCI-to-AD Conversion for Long-Term, Automatic Prognosis of MCI Patients
Aksu, Yaman; Miller, David J.; Kesidis, George; Bigler, Don C.; Yang, Qing X.
2011-01-01
Alzheimer's disease (AD) and mild cognitive impairment (MCI) are of great current research interest. While there is no consensus on whether MCIs actually “convert” to AD, this concept is widely applied. Thus, the more important question is not whether MCIs convert, but what is the best such definition. We focus on automatic prognostication, nominally using only a baseline brain image, of whether an MCI will convert within a multi-year period following the initial clinical visit. This is not a traditional supervised learning problem since, in ADNI, there are no definitive labeled conversion examples. It is not unsupervised, either, since there are (labeled) ADs and Controls, as well as cognitive scores for MCIs. Prior works have defined MCI subclasses based on whether or not clinical scores significantly change from baseline. There are concerns with these definitions, however, since, e.g., most MCIs (and ADs) do not change from a baseline CDR = 0.5 at any subsequent visit in ADNI, even while physiological changes may be occurring. These works ignore rich phenotypical information in an MCI patient's brain scan and labeled AD and Control examples, in defining conversion. We propose an innovative definition, wherein an MCI is a converter if any of the patient's brain scans are classified “AD” by a Control-AD classifier. This definition bootstraps design of a second classifier, specifically trained to predict whether or not MCIs will convert. We thus predict whether an AD-Control classifier will predict that a patient has AD. Our results demonstrate that this definition leads not only to much higher prognostic accuracy than by-CDR conversion, but also to subpopulations more consistent with known AD biomarkers (including CSF markers). We also identify key prognostic brain region biomarkers. PMID:22022375
The AdS central charge in string theory
NASA Astrophysics Data System (ADS)
Troost, Jan
2011-11-01
We evaluate the vacuum expectation value of the central charge operator in string theory in an AdS3 vacuum. Our calculation provides a rare non-zero one-point function on a spherical worldsheet. The evaluation involves the regularization both of a worldsheet ultraviolet divergence (associated to the infinite volume of the conformal Killing group), and a space-time infrared divergence (corresponding to the infinite volume of space-time). The two divergences conspire to give a finite result, which is the classical general relativity value for the central charge, corrected in bosonic string theory by an infinite series of tree level higher derivative terms.
NASA Technical Reports Server (NTRS)
Brown, Shannon; Misra, Sidharth
2013-01-01
The Aquarius/SAC-D mission was launched on June 10, 2011 from Vandenberg Air Force Base. Aquarius consists of an L-band radiometer and scatterometer intended to provide global maps of sea surface salinity. One of the main mission objectives is to provide monthly global salinity maps for climate studies of ocean circulation, surface evaporation and precipitation, air/sea interactions and other processes. Therefore, it is critical that any spatial or temporal systematic biases be characterized and corrected. One of the main mission requirements is to measure salinity with an accuracy of 0.2 psu on montly time scales which requires a brightness temperature stability of about 0.1K, which is a challenging requirement for the radiometer. A secondary use of the Aquarius data is for soil moisture applications, which requires brightness temperature stability at the warmer end of the brightness temperature dynamic range. Soon after launch, time variable drifts were observed in the Aquarius data compared to in-situ data from ARGO and models for the ocean surface salinity. These drifts could arise from a number of sources, including the various components of the retrieval algorithm, such as the correction for direct and reflected galactic emission, or from the instrument brightness temperature calibration. If arising from the brightness temperature calibration, they could have gain and offset components. It is critical that the nature of the drifts be understood before a suitable correction can be implemented. This paper describes the approach that was used to detect and characterize the components of the drift that were in the brightness temperature calibration using on-Earth reference targets that were independent of the ocean model.
Farnham, Irene
2005-09-01
Frenchman Flat is one of several areas of the Nevada Test Site (NTS) used for underground nuclear testing (Figure 1-1). These nuclear tests resulted in groundwater contamination in the vicinity of the underground test areas. As a result, the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) is currently conducting a corrective action investigation (CAI) of the Frenchman Flat underground test areas. Since 1996, the Nevada Division of Environmental Protection (NDEP) has regulated NNSA/NSO corrective actions through the ''Federal Facility Agreement and Consent Order'' ([FFACO], 1996). Appendix VI of the FFACO agreement, ''Corrective Action Strategy'', was revised on December 7, 2000, and describes the processes that will be used to complete corrective actions, including those in the Underground Test Area (UGTA) Project. The individual locations covered by the agreement are known as corrective action sites (CASs), which are grouped into corrective action units (CAUs). The UGTA CASs are grouped geographically into five CAUs: Frenchman Flat, Central Pahute Mesa, Western Pahute Mesa, Yucca Flat/Climax Mine, and Rainier Mesa/Shoshone Mountain (Figure 1-1). These CAUs have distinctly different contaminant source, geologic, and hydrogeologic characteristics related to their location (FFACO, 1996). The Frenchman Flat CAU consists of 10 CASs located in the northern part of Area 5 and the southern part of Area 11 (Figure 1-1). This report documents the evaluation of the information and data available on the unclassified source term and radionuclide contamination for Frenchman Flat, CAU 98. The methodology used to estimate hydrologic source terms (HSTs) for the Frenchman Flat CAU is also documented. The HST of an underground nuclear test is the portion of the total inventory of radionuclides that is released over time into the groundwater following the test. The total residual inventory of radionuclides associated with one or
NASA Astrophysics Data System (ADS)
Asikainen, Timo; Mursula, Kalevi
2014-06-01
We study the relationship between energetic 120-250 keV proton fluxes and geomagnetic Ap, AE, Dxt indices using the recently corrected measurements of the MEPED instrument onboard the low-altitude NOAA/POES satellites. Corrected database spans from 1979 to present, and allows us to reliably study the long-term variation of energetic proton fluxes over several solar cycles. Contrary to uncorrected fluxes, which can be more than an order of magnitude too low, the corrected fluxes display a systematic solar cycle variation closely resembling the variation of Ap and AE indices with a maximum in the declining solar cycle phase and a minimum in solar minimum. We also find that trapped fluxes are enhanced relative to precipitating fluxes in the declining phases and solar minima. This supports the fact that high-speed solar wind streams are the most significant driver of energetic proton fluxes. We compute the correlations between fluxes and indices in a range of time scales, and show that they are significantly improved by the flux correction. We find that precipitating fluxes correlate better than trapped fluxes with Ap/AE indices at all time scales, and the highest correlation is found with Ap. For precipitating fluxes these correlations depend weakly on time scale, but for trapped fluxes the correlation significantly increases from daily scale to solar rotation and longer time scales. Comparing the fluxes to Dxt index shows a complex relationship, where the fluxes depend not only on Dxt value but also on its time derivative.
Guenzel, Adam J.; Collard, Renata; Kraus, Jan P.; Matern, Dietrich
2015-01-01
Abstract Propionic academia (PA) occurs because of mutations in the PCCA or PCCB genes encoding the two subunits of propionyl-CoA carboxylase, a pivotal enzyme in the breakdown of certain amino acids and odd-chain fatty acids. There is no cure for PA, but dietary protein restriction and liver transplantation can attenuate its symptoms. We show here that a single intravenous injection of adeno-associated virus 2/8 (AAV8) or AAVrh10 expressing PCCA into PA hypomorphic mice decreased systemic propionylcarnitine and methyl citrate for up to 1.5 years. However, long-term phenotypic correction was always better in male mice. AAV-mediated PCCA expression was similar in most tissues in males and females at early time points and differed only in the liver. Over 1.5 years, luciferase and PCCA expression remained elevated in cardiac tissue for both sexes. In contrast, transgene expression in the liver and skeletal muscles of female, but not male, mice waned—suggesting that these tissues were major sinks for systemic phenotypic correction. These data indicate that single systemic intravenous therapy by AAV vectors can mediate long-term phenotype correction for PA. However, tissue-specific loss of expression in females reduces efficacy when compared with males. Whether similar sex-biased AAV effects occur in human gene therapy remains to be determined. PMID:25654275
Guenzel, Adam J; Collard, Renata; Kraus, Jan P; Matern, Dietrich; Barry, Michael A
2015-03-01
Propionic academia (PA) occurs because of mutations in the PCCA or PCCB genes encoding the two subunits of propionyl-CoA carboxylase, a pivotal enzyme in the breakdown of certain amino acids and odd-chain fatty acids. There is no cure for PA, but dietary protein restriction and liver transplantation can attenuate its symptoms. We show here that a single intravenous injection of adeno-associated virus 2/8 (AAV8) or AAVrh10 expressing PCCA into PA hypomorphic mice decreased systemic propionylcarnitine and methyl citrate for up to 1.5 years. However, long-term phenotypic correction was always better in male mice. AAV-mediated PCCA expression was similar in most tissues in males and females at early time points and differed only in the liver. Over 1.5 years, luciferase and PCCA expression remained elevated in cardiac tissue for both sexes. In contrast, transgene expression in the liver and skeletal muscles of female, but not male, mice waned—suggesting that these tissues were major sinks for systemic phenotypic correction. These data indicate that single systemic intravenous therapy by AAV vectors can mediate long-term phenotype correction for PA. However, tissue-specific loss of expression in females reduces efficacy when compared with males. Whether similar sex-biased AAV effects occur in human gene therapy remains to be determined. PMID:25654275
NASA Astrophysics Data System (ADS)
Gorbarenko, E. V.; Rublev, A. N.
2016-03-01
We have estimated and compensated the error in long-term series of the aerosol optical thickness (AOT) calculated from the data on direct integral solar radiation measured by a standard actinometer at the Meteorological Observatory of the Moscow State University (MO MSU) for strong atmospheric turbidity conditions. The necessary corrections have been obtained by the Monte-Carlo simulation of the actinometry measurements for different atmospheric conditions, taking into account the angular size of the field of view of the instrument; and a special correctional formula has been obtained. This correction formula has been applied for all timed AOT values of above 0.5 observed at the MO MSU for the entire time period from 1955 to 2013. Changes in the long-term average AOT values in Moscow occurred only when the smoky haze from the forest and peat fires affected the aerosol turbidity of the atmosphere. Here, the significant decreasing trend of aerosol optical depth of the atmosphere from 1955 to 2013 has been retained with the same confidence level.
Hu, Chuhong; Lipshutz, Gerald S.
2012-01-01
Hemophilia A gene therapy has been hampered by immune responses to vector-associated antigens and by neutralizing antibodies or inhibitors to the factor VIII (FVIII) protein; these ‘inhibitors’ more commonly effect hemophilia A patients than those with hemophilia B. A gene replacement strategy beginning in the neonatal period may avoid the development of these immune responses and lead to prolonged expression with correction of phenotype thereby avoiding long-term consequences. Serotype rh10 AAV was developed splitting the FVIII coding sequence into heavy and light chains with the chicken β-actin promoter/CMV enhancer for dual recombinant AAV vector delivery. Coinjection of virions of each FVIII chain intravenously to mice on the second day of life was performed. Mice express sustained FVIII antigen levels of ≥5% to 22 months of life without the development of antibodies to FVIII. Phenotypic correction was manifest in all AAV-FVIII-treated mice as demonstrated by functional assay and reduction in bleeding time. This study demonstrates the use of AAV in a gene replacement strategy in neonatal mice that establishes both long-term phenotypic correction of hemophilia A and lack of antibody development to FVIII in this disease model where AAV is administered shortly after birth. These studies support consideration of gene replacement therapy for diseases that are diagnosed in utero or in the early neonatal period. PMID:22241178
Mansbach, William E; Mace, Ryan A
2016-09-01
We compared the accuracy of the Brief Cognitive Assessment Tool-Short Form (BCAT-SF) and AD8 in identifying mild cognitive impairment (MCI) and dementia among long-term care residents. Psychometric analyses of 357 long-term care residents (n = 228, nursing home; n = 129, assisted living) in Maryland referred for neuropsychological evaluation evidenced robust internal consistency reliability and construct validity for the BCAT-SF. Furthermore, hierarchical logistic regression and receiver operating characteristic curve analyses demonstrated superior predictive validity for the BCAT-SF in identifying MCI and dementia relative to the AD8. In contrast, previously reported psychometric properties or cut scores for the AD8 could not be cross-validated in this long-term care sample. Based on these findings, the BCAT-SF appears to be a more reliable and valid screening instrument than the AD8 for rapidly identifying MCI and dementia in long-term care residents. PMID:26873431
NASA Astrophysics Data System (ADS)
Schlaf, R.; Lang, O.; Pettenkofer, C.; Jaegermann, W.
1999-03-01
The occurrence of quantum dipoles at layered materials semiconductor heterointerfaces was investigated by photoemission spectroscopy (PES). Due to the unique properties of layered compounds the prepared interfaces are essentially free of the structural problems known from the usually investigated heterosystems composed of III-V, IV or II-VI materials allowing the detailed investigation of electronic phenomena at the interfaces. We investigated heterostructures composed of epitaxial layers of SnS2 and SnSe2 on different single crystalline layered chalcogenide substrates (WSe2, MoS2, MoTe2, and GaSe). The epilayers were grown by van der Waals epitaxy (vdWe) on the (0001) plane of the substrate crystals. For every system the valence band offset was determined by careful evaluation of the PES data as a function of the film thickness. Using published values for the band gaps and the experimentally determined work functions and surface potentials the band lineup for each system was determined. The band offsets of all systems were found to differ from the prediction of the electron affinity rule (EAR) by a small systematic deviation which was related to the occurrence of localized quantum dipoles at the interface. This deviation can be expressed as a linear charge transfer correction term added to the original EAR. This corrected EAR is still a linear rule allowing the assignment of "characteristic energies" to each material for the calculation of the band offset. We could demonstrate that the error margin of the corrected EAR lies well within the experimental error of PES experiments, thus proving the general applicability of linear laws for the determination of the band offset in absence of structural dipoles.
ERIC Educational Resources Information Center
Hollingworth, Andrew; Richard, Ashleigh M.; Luck, Steven J.
2008-01-01
Visual short-term memory (VSTM) has received intensive study over the past decade, with research focused on VSTM capacity and representational format. Yet, the function of VSTM in human cognition is not well understood. Here, the authors demonstrate that VSTM plays an important role in the control of saccadic eye movements. Intelligent human…
Bittner, T C; Pannicke, U; Renner, E D; Notheis, G; Hoffmann, F; Belohradsky, B H; Wintergerst, U; Hauser, M; Klein, B; Schwarz, K; Schmid, I; Albert, M H
2010-11-01
Autosomal dominant hyper-IgE syndrome (AD-HIES), characterised by eczema, increased susceptibility to skin and lung infections, elevated IgE and skeletal abnormalities is associated with heterozygous STAT3 mutations. The autosomal recessive variant (AR-HIES) has similar immunological findings but mainly lacks extraimmune manifestations. Several AR-HIES patients have recently been shown to harbour mutations in the gene for dedicator of cytokinesis 8 (DOCK8). Here, we present the long-term outcome of a girl having received a hematopoietic stem cell graft for an at that time genetically undefined combined immunodeficiency associated with severe eczema, multiple food allergies, excessively elevated serum IgE levels and eosinophilia. She was recently found to carry a homozygous nonsense mutation in the DOCK8 gene. HSCT resulted in complete immunological correction, even though mixed donor chimerism occurred. Clinically, the outcome was characterised by disappearance of skin manifestations and severe infections, improvement of pulmonary function and constant decline of IgE levels. Outcome in untransplanted DOCK8 deficient patients is poor because of frequent life-threatening infections, CNS bleeding and infarction, and increased susceptibility to malignancy. This argues for early curative therapeutic approaches, supported by this report of successful long-term outcome after HSCT. PMID:21058221
Detecting and correcting sensor drifts in long-term weather data.
von Arx, Georg; Dobbertin, Matthias; Rebetez, Martine
2013-06-01
Quality control of long-term monitoring data of thousands and millions of individual records as present in meteorological data is cumbersome. In such data series, sensor drifts, stalled values, and scale shifts may occur and potentially result in flawed conclusions if not noticed and handled properly. However, there is no established standard procedure to perform quality control of high-frequency meteorological data. In this paper, we outline a procedure to remove sensor drift in high-frequency data series using the example of 15-year-long sets of hourly relative humidity (RH) data from 28 stations subdivided into 202 individual sensor operation periods. The procedure involves basic quality control, relative homogeneity testing, and drift removal. Significant sensor drifts were observed in 40.6 % of all sensor operation periods. The drifts varied between data series and depended in a complex, usually inconsistent way on absolute RH values; within single series for instance, a drift could be negative in the lower RH range and positive in the upper RH range. Detrending changed RH values by, on average, 1.96 %. For one fifth of the detrended data, adjustments were 2.75 % and more of the measured value, and in one tenth 4.75 % and more. Overall, drifts were strongest for RH values close to 100 %. The detrending procedure proved to effectively remove sensor drifts. The principles of the procedure also apply to other meteorological parameters and more generally to any time series of data for which comparable reference data are available. PMID:22915222
Benet, S B; Bloom, P N
1998-01-01
The ingredients for a financial calamity affecting both government and individual citizens and their families are in place. Federal legislators have made little progress in addressing the health care needs of an aging America, and the proposals that have been advanced offer little or nothing in the way of better help with long-term care. One potential scenario is that middle-income retirees placed in long-term care will exhaust their finances and then turn to Medicaid, creating an enormous expense for the government. Long-term care insurance could alleviate the situation, but current practices by the insurance industry in marketing products to the elderly complicate the sale of such insurance. Consumers approaching retirement age are receptive to this type of product, but first they must be made aware of the merits of long-term care insurance and the paucity of alternatives. Only then can marketers promote specific products successfully. PMID:10179394
Method for detecting and correcting for isotope burn-in during long-term neutron dosimetry exposure
Ruddy, Francis H.
1988-01-01
A method is described for detecting and correcting for isotope burn-in during-long term neutron dosimetry exposure. In one embodiment, duplicate pairs of solid state track recorder fissionable deposits are used, including a first, fissionable deposit of lower mass to quantify the number of fissions occuring during the exposure, and a second deposit of higher mass to quantify the number of atoms of for instance .sup.239 Pu by alpha counting. In a second embodiment, only one solid state track recorder fissionable deposit is used and the resulting higher track densities are counted with a scanning electron microscope. This method is also applicable to other burn-in interferences, e.g., .sup.233 U in .sup.232 Th or .sup.238 Pu in .sup.237 Np.
Long-Term Correction of Sandhoff Disease Following Intravenous Delivery of rAAV9 to Mouse Neonates
Walia, Jagdeep S; Altaleb, Naderah; Bello, Alexander; Kruck, Christa; LaFave, Matthew C; Varshney, Gaurav K; Burgess, Shawn M; Chowdhury, Biswajit; Hurlbut, David; Hemming, Richard; Kobinger, Gary P; Triggs-Raine, Barbara
2015-01-01
GM2 gangliosidoses are severe neurodegenerative disorders resulting from a deficiency in β-hexosaminidase A activity and lacking effective therapies. Using a Sandhoff disease (SD) mouse model (Hexb−/−) of the GM2 gangliosidoses, we tested the potential of systemically delivered adeno-associated virus 9 (AAV9) expressing Hexb cDNA to correct the neurological phenotype. Neonatal or adult SD and normal mice were intravenously injected with AAV9-HexB or –LacZ and monitored for serum β-hexosaminidase activity, motor function, and survival. Brain GM2 ganglioside, β-hexosaminidase activity, and inflammation were assessed at experimental week 43, or an earlier humane end point. SD mice injected with AAV9-LacZ died by 17 weeks of age, whereas all neonatal AAV9-HexB–treated SD mice survived until 43 weeks (P < 0.0001) with only three exhibiting neurological dysfunction. SD mice treated as adults with AAV9-HexB died between 17 and 35 weeks. Neonatal SD-HexB–treated mice had a significant increase in brain β-hexosaminidase activity, and a reduction in GM2 ganglioside storage and neuroinflammation compared to adult SD-HexB– and SD-LacZ–treated groups. However, at 43 weeks, 8 of 10 neonatal-HexB injected control and SD mice exhibited liver or lung tumors. This study demonstrates the potential for long-term correction of SD and other GM2 gangliosidoses through early rAAV9 based systemic gene therapy. PMID:25515709
NASA Astrophysics Data System (ADS)
Gregory, Roger B.
1991-05-01
We have recently described modifications to the program CONTIN [S.W. Provencher, Comput. Phys. Commun. 27 (1982) 229] for the solution of Fredholm integral equations with convoluted kernels of the type that occur in the analysis of positron annihilation lifetime data [R.B. Gregory and Yongkang Zhu, Nucl. Instr. and Meth. A290 (1990) 172]. In this article, modifications to the program to correct for source terms in the sample and reference decay curves and for shifts in the position of the zero-time channel of the sample and reference data are described. Unwanted source components, expressed as a discrete sum of exponentials, may be removed from both the sample and reference data by modification of the sample data alone, without the need for direct knowledge of the instrument resolution function. Shifts in the position of the zero-time channel of up to half the channel width of the multichannel analyzer can be corrected. Analyses of computer-simulated test data indicate that the quality of the reconstructed annihilation rate probability density functions is improved by employing a reference material with a short lifetime and indicate that reference materials which generate free positrons by quenching positronium formation (i.e. strong oxidizing agents) have lifetimes that are too long (400-450 ps) to provide reliable estimates of the lifetime parameters for the shortlived components with the methods described here. Well-annealed single crystals of metals with lifetimes less than 200 ps, such as molybdenum (123 ps) and aluminum (166 ps) do not introduce significant errors in estimates of the lifetime parameters and are to be preferred as reference materials. The performance of our modified version of CONTIN is illustrated by application to positron annihilation in polytetrafluoroethylene.
Long-term correction of Sandhoff disease following intravenous delivery of rAAV9 to mouse neonates.
Walia, Jagdeep S; Altaleb, Naderah; Bello, Alexander; Kruck, Christa; LaFave, Matthew C; Varshney, Gaurav K; Burgess, Shawn M; Chowdhury, Biswajit; Hurlbut, David; Hemming, Richard; Kobinger, Gary P; Triggs-Raine, Barbara
2015-03-01
G(M2) gangliosidoses are severe neurodegenerative disorders resulting from a deficiency in β-hexosaminidase A activity and lacking effective therapies. Using a Sandhoff disease (SD) mouse model (Hexb(-/-)) of the G(M2) gangliosidoses, we tested the potential of systemically delivered adeno-associated virus 9 (AAV9) expressing Hexb cDNA to correct the neurological phenotype. Neonatal or adult SD and normal mice were intravenously injected with AAV9-HexB or -LacZ and monitored for serum β-hexosaminidase activity, motor function, and survival. Brain G(M2) ganglioside, β-hexosaminidase activity, and inflammation were assessed at experimental week 43, or an earlier humane end point. SD mice injected with AAV9-LacZ died by 17 weeks of age, whereas all neonatal AAV9-HexB-treated SD mice survived until 43 weeks (P < 0.0001) with only three exhibiting neurological dysfunction. SD mice treated as adults with AAV9-HexB died between 17 and 35 weeks. Neonatal SD-HexB-treated mice had a significant increase in brain β-hexosaminidase activity, and a reduction in G(M2) ganglioside storage and neuroinflammation compared to adult SD-HexB- and SD-LacZ-treated groups. However, at 43 weeks, 8 of 10 neonatal-HexB injected control and SD mice exhibited liver or lung tumors. This study demonstrates the potential for long-term correction of SD and other G(M2) gangliosidoses through early rAAV9 based systemic gene therapy. PMID:25515709
Black hole microstates in AdS4 from supersymmetric localization
NASA Astrophysics Data System (ADS)
Benini, Francesco; Hristov, Kiril; Zaffaroni, Alberto
2016-05-01
This paper addresses a long standing problem, the counting of the microstates of supersymmetric asymptotically AdS black holes in terms of a holographically dual field theory. We focus on a class of asymptotically AdS4 static black holes preserving two real supercharges which are dual to a topologically twisted deformation of the ABJM theory. We evaluate in the large N limit the topologically twisted index of the ABJM theory and we show that it correctly reproduces the entropy of the AdS4 black holes. An extremization of the index with respect to a set of chemical potentials is required. We interpret it as the selection of the exact R-symmetry of the superconformal quantum mechanics describing the horizon of the black hole.
Rojas-Martínez, A; Manzanera, A G; Sukin, S W; Esteban-María, J; González-Guerrero, J F; Gomez-Guerra, L; Garza-Guajardo, R; Flores-Gutiérrez, J P; Elizondo Riojas, G; Delgado-Enciso, I; Ortiz-López, R; Aguilar, L K; Butler, E B; Barrera-Saldaña, H A; Aguilar-Cordova, E
2013-11-01
A phase I-II study to evaluate gene-mediated cytotoxic immunotherapy in newly diagnosed prostate cancer before radical prostatectomy was conducted in Monterrey, Mexico. First, to investigate delivery of adenovirus to the prostate, fluorescently labeled vector was injected into fresh prostatectomy specimens and distribution was visually analyzed. The optimal volume and site instillation was then used for transrectal ultrasound guided intraprostatic injection in 10 patients with adenocarcinoma scheduled for radical prostatectomy. Each received two apical and two basal 0.5 ml injections of AdV-tk for a total of 1 × 10(11) vp followed by 14 days of prodrug. Nine patients continued to tumor resection: six high risk, one intermediate and two low risk. In vivo vector distribution was analyzed from the resected tissue of four patients. Patients were monitored for tumor progression and acute and long-term safety. For vector delivery, two apical and two basal injections of 0.5 ml led to optimal organ-wide distribution ex vivo and in vivo. Cytotoxicity was evidenced by transient rise in PSA and tumor histology. There were no significant adverse events deemed related to the treatment and no late toxicities after median follow-up of 11.3 years. All six high-risk patients had positive surgical margins and one had seminal vesicle involvement. Despite slow PSA rise post surgery in three of these patients, none developed metastases. The intermediate- and low-risk patients had complete resections and none have progressed. In conclusion, in vivo transrectal ultrasound guided instillation of an adenoviral vector into four sites in the prostate was practical as an outpatient procedure, well tolerated and led to distribution throughout the intraprostatic tumor mass. AdV-tk demonstrated no significant acute or late toxicities. Trends in PSA and disease progression conveyed the possibility of a sustained immune response against residual disease. PMID:24052127
Rojas-Martínez, Augusto; Manzanera, Andrea G.; Sukin, Steven W.; Esteban-María, Jacinto; González-Guerrero, Juan Francisco; Gomez-Guerra, Lauro; Garza-Guajardo, Raquel; Flores-Gutiérrez, Juan Pablo; Riojas, Guillermo Elizondo; Delgado-Enciso, Iván; Ortiz-López, Rocío; Aguilar, Laura K.; Butler, E. Brian; Barrera-Saldaña, Hugo A.; Aguilar-Cordova, Estuardo
2013-01-01
A phase I-II study to evaluate gene mediated cytotoxic immunotherapy in newly diagnosed prostate cancer before radical prostatectomy was conducted in Monterrey, Mexico. Methods To investigate delivery of adenovirus to the prostate, fluorescently labeled vector was injected into fresh prostatectomy specimens and distribution visually analyzed. The optimal volume and site instillation was then used for transrectal ultrasound guided intraprostatic injection in 10 patients with adenocarcinoma scheduled for radical prostatectomy. Each received 2-apical and 2-basal 0.5 ml injections of AdV-tk for a total of 1×1011 vp followed by 14 days of prodrug. Nine patients continued to tumor resection: 6 high-risk, 1 intermediate and 2 low-risk. In-vivo vector distribution was analyzed from resected tissue of four patients. Patients were monitored for tumor progression and acute and long-term safety. Results Two apical and two basal injections of 0.5ml led to optimal organ-wide distribution of an adenoviral vector ex-vivo and in-vivo. Cytotoxicity was evidenced by transient rise in PSA and tumor histology. There were no significant adverse events deemed related to the treatment and no late toxicities after median follow up of 11.3 years. All six high-risk patients had positive surgical margins and one had seminal vesicle involvement. Despite slow PSA rise post-surgery in 3 of these patients, none developed metastases. The intermediate and low-risk patients had complete resections and none have progressed. Conclusion In-vivo transrectal ultrasound guided instillation of an adenoviral vector into four sites in the prostate was practical as an outpatient procedure, well tolerated and led to distribution throughout the intraprostatic tumor mass. AdV-tk demonstrated no significant acute or late toxicities. Trends in PSA and disease progression conveyed the possibility of a sustained immune response against residual disease. PMID:24052127
ERIC Educational Resources Information Center
Tonisson, Eno; Lepp, Marina
2015-01-01
The answers offered by computer algebra systems (CAS) can sometimes differ from those expected by the students or teachers. The comparison of the students' answers and CAS answers could provide ground for discussion about equivalence and correctness. Investigating the students' comparison of the answers gives the possibility to study different…
Bernstein, David M.; Rogers, Rick; Sepulveda, Rosalina; Kunzendorf, Peter; Bellmann, Bernd; Ernst, Heinrich; Phillips, James I.
2014-04-01
Chrysotile has been frequently used in the past in manufacturing brakes and continues to be used in brakes in many countries. This study was designed to provide an understanding of the biokinetics and potential toxicology following inhalation of brake dust following short term exposure in rats. The deposition, translocation and pathological response of brake dust derived from brake pads manufactured with chrysotile were evaluated in comparison to the amphibole, crocidolite asbestos. Rats were exposed by inhalation 6 h/day for 5 days to either brake dust obtained by sanding of brake-drums manufactured with chrysotile, a mixture of chrysotile and the brake dust or crocidolite asbestos. No significant pathological response was observed at any time point in either the brake dust or chrysotile/brake dust exposure groups. The long chrysotile fibers (> 20 μm) cleared quickly with T{sub 1/2} estimated as 30 and 33 days, respectively in the brake dust and the chrysotile/brake dust exposure groups. In contrast, the long crocidolite fibers had a T{sub 1/2} > 1000 days and initiated a rapid inflammatory response in the lung following exposure resulting in a 5-fold increase in fibrotic response within 91 days. These results provide support that brake dust derived from chrysotile containing brake drums would not initiate a pathological response in the lung following short term inhalation. - Highlights: • We evaluated brake dust w/wo added chrysotile in comparison to crocidolite asbestos. • Persistence, translocation, pathological response in the lung and pleural cavity. • Chrysotile cleared rapidly from the lung while the crocidolite asbestos persisted. • No significant pathology observed at any time point in the brake-dust groups. • Crocidolite produced pathological response - Wagner 4 interstitial fibrosis by 32d.
ERIC Educational Resources Information Center
UCLA IDEA, 2012
2012-01-01
Value added measures (VAM) uses changes in student test scores to determine how much "value" an individual teacher has "added" to student growth during the school year. Some policymakers, school districts, and educational advocates have applauded VAM as a straightforward measure of teacher effectiveness: the better a teacher, the better students…
Akune, Kenta; Maeda, Kei-ichi; Ohta, Nobuyoshi
2006-05-15
We present a detailed study of inflationary solutions in M theory with higher order quantum corrections. We first exhaust all exact and asymptotic solutions of exponential and power-law expansions in this theory with quartic curvature corrections, and then perform a linear perturbation analysis around fixed points for the exact solutions in order to see which solutions are more generic and give interesting cosmological models. We find an interesting solution in which the external space expands exponentially and the internal space is static both in the original and Einstein frames. Furthermore, we perform a numerical calculation around this solution and find numerical solutions which give enough e-foldings. We also briefly summarize similar solutions in type II superstrings.
Fujiwara, Takahisa; Suzuki, Yoshihisa; Yoshizaki, Izumi; Tsukamoto, Katsuo; Murayama, Kenta; Fukuyama, Seijiro; Hosokawa, Kouhei; Oshi, Kentaro; Ito, Daisuke; Yamazaki, Tomoya; Tachibana, Masaru; Miura, Hitoshi
2015-08-01
The normal growth rates of the {110} faces of tetragonal hen egg-white lysozyme crystals, R, were measured as a function of the supersaturation σ parameter using a reflection type interferometer under μG at the International Space Station (NanoStep Project). Since water slightly evaporated from in situ observation cells during a long-term space station experiment for several months, equilibrium temperature T(e) changed, and the actual σ, however, significantly increased mainly due to the increase in salt concentration C(s). To correct σ, the actual C(s) and protein concentration C(p), which correctly represent the measured T(e) value in space, were first calculated. Second, a new solubility curve with the corrected C(s) was plotted. Finally, the revised σ was obtained from the new solubility curve. This correction method successfully revealed that the 2.8% water was evaporated from the solution, leading to 2.8% increase in the C(s) and C(p) of the solution. PMID:26329200
Gau, Chia-Ling; Rosenblatt, Robin A; Cerullo, Vincenzo; Lay, Fides D; Dow, Adrienne C; Livesay, Justin; Brunetti-Pierri, Nicola; Lee, Brendan; Cederbaum, Stephen D; Grody, Wayne W; Lipshutz, Gerald S
2009-01-01
Neonatal gene therapy has the potential to ameliorate abnormalities before disease onset. Our gene knockout of arginase I (AI) deficiency is characterized by increasing hyperammonemia, neurological deterioration, and early death. We constructed a helper-dependent adenoviral vector (HDV) carrying AI and examined for correction of this defect. Neonates were administered 5 × 109 viral particles/g and analyzed for survival, arginase activity, and ammonia and amino acids levels. The life expectancy of arg−/− mice increased to 27 days while controls died at 14 days with hyperammonemia and in extremis. Death correlated with a decrease in viral DNA/RNA per cell as liver mass increased. Arginase assays demonstrated that vector-injected hepatocytes had ~20% activity of heterozygotes at 2 weeks of age. Hepatic arginine and ornithine in treated mice were similar to those of saline-injected heterozygotes at 2 weeks, whereas ammonia was normal. By 26 days, arginase activity in the treated arg−/− livers declined to <10%, and arginine and ornithine increased. Ammonia levels began increasing by day 25, suggesting the cause of death to be similar to that of uninjected arg−/− mice, albeit at a later time. These studies demonstrate that the AI deficient newborn mouse can be temporarily corrected and rescued using a HDV. PMID:19367256
Patil, Shruti Arun; Kulkarni, Sudhindra; Thakur, Srinath; Naik, Balaram
2016-01-01
Context: The crown lengthening procedure (CLP) is routinely carried out to correct gingival levels and achieve esthetic contours and adequate crown lengths for restorative purposes. Though the short-term outcomes have been found to be stable, long-term results are not much reported. Aims: To evaluate the long-term stability of the marginal bone levels, gingival levels, and the status of the teeth, which underwent endodontic therapy, followed by CLP and final restorations. Settings and Design: Institutional setting, long-term case series. Materials and Methods: Case records of the patients who underwent CLP and endodontic therapy for corrections of the supra-erupted teeth to regain the lost interocclusal spaces were retrieved, and the cases with complete set of the clinical and radiographs were taken. All the cases were recalled and bone levels on the radiographs, bleeding on probing, probing pocket depths, and changes in the soft tissue margins were evaluated. Statistical Analysis Used: Descriptive analysis. Results: A total of 25 teeth had undergone CLP and endodontic therapy and final restorations for a minimum of 24 months. The mean post-restorative duration was 50.8 ± 22.48 months (range 24–96 months). All the teeth were functional and asymptomatic with 100% survival. Interdental bone loss of 1 mm, probing pockets of 5 mm, and 1 mm buccal recession were observed in 16% of the sites. The amount of interocclusal space regained was adequate to restore the missing teeth in the opposing arch. Conclusions: The CLP is a predictive procedure for correction of supra-erupted teeth. The survival of the teeth that underwent the procedure in the present study was 100% over 24–96 months. PMID:27041850
Pereira, A B D; Utsumi, S A; Dorich, C D; Brito, A F
2015-12-01
The objective of this study was to use spot short-term measurements of CH4 (QCH4) and CO2 (QCO2) integrated with backward dietary energy partition calculations to estimate dry matter intake (DMI) in lactating dairy cows. Twelve multiparous cows averaging 173±37d in milk and 4 primiparous cows averaging 179±27d in milk were blocked by days in milk, parity, and DMI (as a percentage of body weight) and, within each block, randomly assigned to 1 of 2 treatments: ad libitum intake (AL) or restricted intake (RI=90% DMI) according to a crossover design. Each experimental period lasted 22d with 14d for treatments adaptation and 8d for data and sample collection. Diets contained (dry matter basis): 40% corn silage, 12% grass-legume haylage, and 48% concentrate. Spot short-term gas measurements were taken in 5-min sampling periods from 15 cows (1 cow refused sampling) using a portable, automated, open-circuit gas quantification system (GreenFeed, C-Lock Inc., Rapid City, SD) with intervals of 12h between the 2daily samples. Sampling points were advanced 2h from a day to the next to yield 16 gas samples per cow over 8d to account for diurnal variation in QCH4 and QCO2. The following equations were used sequentially to estimate DMI: (1) heat production (MJ/d)=(4.96 + 16.07 ÷ respiratory quotient) × QCO2; respiratory quotient=0.95; (2) metabolizable energy intake (MJ/d)=(heat production + milk energy) ± tissue energy balance; (3) digestible energy (DE) intake (MJ/d)=metabolizable energy + CH4 energy + urinary energy; (4) gross energy (GE) intake (MJ/d)=DE + [(DE ÷ in vitro true dry matter digestibility) - DE]; and (5) DMI (kg/d)=GE intake estimated ÷ diet GE concentration. Data were analyzed using the MIXED procedure of SAS (SAS Institute Inc., Cary, NC) and Fit Model procedure in JMP (α=0.05; SAS Institute Inc.). Cows significantly differed in DMI measured (23.8 vs. 22.4kg/d for AL and RI, respectively). Dry matter intake estimated using QCH4 and QCO2 coupled with
Systematics of Coupling Flows in AdS Backgrounds
Goldberger, Walter D.; Rothstein, Ira Z.
2003-03-18
We give an effective field theory derivation, based on the running of Planck brane gauge correlators, of the large logarithms that arise in the predictions for low energy gauge couplings in compactified AdS}_5 backgrounds, including the one-loop effects of bulk scalars, fermions, and gauge bosons. In contrast to the case of charged scalars coupled to Abelian gauge fields that has been considered previously in the literature, the one-loop corrections are not dominated by a single 4D Kaluza-Klein mode. Nevertheless, in the case of gauge field loops, the amplitudes can be reorganized into a leading logarithmic contribution that is identical to the running in 4D non-Abelian gauge theory, and a term which is not logarithmically enhanced and is analogous to a two-loop effect in 4D. In a warped GUT model broken by the Higgs mechanism in the bulk,we show that the matching scale that appears in the large logarithms induced by the non-Abelian gauge fields is m_{XY}^2/k where m_{XY} is the bulk mass of the XY bosons and k is the AdS curvature. This is in contrast to the UV scale in the logarithmic contributions of scalars, which is simply the bulk mass m. Our results are summarized in a set of simple rules that can be applied to compute the leading logarithmic predictions for coupling constant relations within a given warped GUT model. We present results for both bulk Higgs and boundary breaking of the GUT gauge
ERIC Educational Resources Information Center
Orsini, Larry L.; Hudack, Lawrence R.; Zekan, Donald L.
1999-01-01
The value-added statement (VAS), relatively unknown in the United States, is used in financial reports by many European companies. Saint Bonaventure University (New York) has adapted a VAS to make it appropriate for not-for-profit universities by identifying stakeholder groups (students, faculty, administrators/support personnel, creditors, the…
Full halo coronal mass ejections: Do we need to correct the projection effect in terms of velocity?
NASA Astrophysics Data System (ADS)
Shen, C.; Wang, Y.; Pan, Z.; Zhang, M.; Ye, P.; Wang, S.
2013-12-01
The projection effect would distort our understanding of coronal mass ejections (CMEs) and influence the space weather forecasting. To evaluate the projection effect, the de-projected kinematic parameters of full halo CMEs (FHCMEs) listed in the CDAW CME catalog from 2007 March 1 to 2012 May 31 are studied by applying the Graduated Cylindrical Shell (GCS) model. It is revealed that, although these CMEs are all full halo in the view angle of SOHO, the de-projected parameters, including the propagation direction and angular width, could vary in a large range. Projection effect is a major but not only reason causing a CME being halo. By comparing the de-projected velocity with projected velocity of these CMEs, we find that not all of FHCMEs need to be corrected for their velocities; Almost all the FHCMEs which have obvious projection effect are originating within 45 of the Sun-Earth line and moving slower than 900 km/s in the plane-of-sky.
Full halo coronal mass ejections: Do we need to correct the projection effect in terms of velocity?
NASA Astrophysics Data System (ADS)
Shen, Chenglong; Wang, Yuming; Pan, Zonghao; Zhang, Min; Ye, Pinzhong; Wang, S.
2013-11-01
The projection effect is one of the biggest obstacles in learning the real properties of coronal mass ejections (CMEs) and forecasting their geoeffectiveness. To evaluate the projection effect, 86 full halo CMEs (FHCMEs) listed in the Coordinated Data Analysis Workshop CME catalog from 1 March 2007 to 31 May 2012 are investigated. By applying the Graduated Cylindrical Shell model, we obtain the deprojected values of the propagation velocity, direction, and angular width of these FHCMEs and compare them with the projected values measured in the plane-of-sky. Although these CMEs look full halo in the view angle of SOHO, it is found that their propagation directions and angular widths could vary in a large range, implying projection effect is a major reason causing a CME being halo, but not the only one. Furthermore, the comparison of the deprojected and projected velocities reveals that most FHCMEs originating within 45° of the Sun-Earth line with a projected speed slower than 900 km s-1 suffer from large projection effect, while the FHCMEs originating far from the vicinity of solar disk center or moving faster than 900 km s-1have small projection effect. Thus, for the latter class of FHCMEs, it is not necessary to correct the measured velocities.
Realizing "value-added" metrology
NASA Astrophysics Data System (ADS)
Bunday, Benjamin; Lipscomb, Pete; Allgair, John; Patel, Dilip; Caldwell, Mark; Solecky, Eric; Archie, Chas; Morningstar, Jennifer; Rice, Bryan J.; Singh, Bhanwar; Cain, Jason; Emami, Iraj; Banke, Bill, Jr.; Herrera, Alfredo; Ukraintsev, Vladamir; Schlessinger, Jerry; Ritchison, Jeff
2007-03-01
The conventional premise that metrology is a "non-value-added necessary evil" is a misleading and dangerous assertion, which must be viewed as obsolete thinking. Many metrology applications are key enablers to traditionally labeled "value-added" processing steps in lithography and etch, such that they can be considered integral parts of the processes. Various key trends in modern, state-of-the-art processing such as optical proximity correction (OPC), design for manufacturability (DFM), and advanced process control (APC) are based, at their hearts, on the assumption of fine-tuned metrology, in terms of uncertainty and accuracy. These trends are vehicles where metrology thus has large opportunities to create value through the engineering of tight and targetable process distributions. Such distributions make possible predictability in speed-sorts and in other parameters, which results in high-end product. Additionally, significant reliance has also been placed on defect metrology to predict, improve, and reduce yield variability. The necessary quality metrology is strongly influenced by not only the choice of equipment, but also the quality application of these tools in a production environment. The ultimate value added by metrology is a result of quality tools run by a quality metrology team using quality practices. This paper will explore the relationships among present and future trends and challenges in metrology, including equipment, key applications, and metrology deployment in the manufacturing flow. Of key importance are metrology personnel, with their expertise, practices, and metrics in achieving and maintaining the required level of metrology performance, including where precision, matching, and accuracy fit into these considerations. The value of metrology will be demonstrated to have shifted to "key enabler of large revenues," debunking the out-of-date premise that metrology is "non-value-added." Examples used will be from critical dimension (CD
McClelland, D; Barlow, D; Moores, T S; Wynn-Jones, C; Griffiths, D; Ogrodnik, P J; Thomas, P B M
2016-05-01
In arthritis of the varus knee, a high tibial osteotomy (HTO) redistributes load from the diseased medial compartment to the unaffected lateral compartment. We report the outcome of 36 patients (33 men and three women) with 42 varus, arthritic knees who underwent HTO and dynamic correction using a Garches external fixator until they felt that normal alignment had been restored. The mean age of the patients was 54.11 years (34 to 68). Normal alignment was achieved at a mean 5.5 weeks (3 to 10) post-operatively. Radiographs, gait analysis and visual analogue scores for pain were measured pre- and post-operatively, at one year and at medium-term follow-up (mean six years; 2 to 10). Failure was defined as conversion to knee arthroplasty. Pre-operative gait analysis divided the 42 knees into two equal groups with high (17 patients) or low (19 patients) adductor moments. After correction, a statistically significant (p < 0.001, t-test,) change in adductor moment was achieved and maintained in both groups, with a rate of failure of three knees (7.1%), and 89% (95% confidence interval (CI) 84.9 to 94.7) survivorship at medium-term follow-up. At final follow-up, after a mean of 15.9 years (12 to 20), there was a survivorship of 59% (95% CI 59.6 to 68.9) irrespective of adductor moment group, with a mean time to conversion to knee arthroplasty of 9.5 years (3 to 18; 95% confidence interval ± 2.5). HTO remains a useful option in the medium-term for the treatment of medial compartment osteoarthritis of the knee but does not last in the long-term. Cite this article: Bone Joint J 2016;98-B:601-7. PMID:27143729
Bianchi, Veronica; Farisello, Pasqualina; Baldelli, Pietro; Meskenaite, Virginia; Milanese, Marco; Vecellio, Matteo; Mühlemann, Sven; Lipp, Hans Peter; Bonanno, Giambattista; Benfenati, Fabio; Toniolo, Daniela; D'Adamo, Patrizia
2009-01-01
The GDI1 gene, responsible in human for X-linked non-specific mental retardation, encodes αGDI, a regulatory protein common to all GTPases of the Rab family. Its alteration, leading to membrane accumulation of different Rab GTPases, may affect multiple steps in neuronal intracellular traffic. Using electron microscopy and electrophysiology, we now report that lack of αGDI impairs several steps in synaptic vesicle (SV) biogenesis and recycling in the hippocampus. Alteration of the SV reserve pool (RP) and a 50% reduction in the total number of SV in adult synapses may be dependent on a defective endosomal-dependent recycling and may lead to the observed alterations in short-term plasticity. As predicted by the synaptic characteristics of the mutant mice, the short-term memory deficit, observed when using fear-conditioning protocols with short intervals between trials, disappeared when the Gdi1 mutants were allowed to have longer intervals between sessions. Likewise, previously observed deficits in radial maze learning could be corrected by providing less challenging pre-training. This implies that an intact RP of SVs is necessary for memory processing under challenging conditions in mice. The possibility to correct the learning deficit in mice may have clinical implication for future studies in human. PMID:18829665
Sun, Jifeng; Wang, Yarong; Yang, Jie; Du, Dewei; Li, Zhanting; Wei, Junxia; Yang, Angang
2012-11-30
Relative deficiency in production of glycoprotein hormone erythropoietin (Epo) is a major cause of renal anemia. This study planned to investigate whether the hypoxia-regulated system of Epo expression, constructed by fusing Epo gene to the chimeric phosphoglycerate kinase (PGK) hypoxia response elements (HRE) in combination with cytomegalovirus immediate- early (CMV IE) basal gene promoter and delivered by plasmid intramuscular injection, might provide a long-term physiologically regulated Epo secretion expression to correct the anemia in adenine-induced uremic rats. Plasmid vectors (pHRE-Epo) were synthesized by fusing human Epo cDNA to the HRE/CMV promoter. Hypoxia-inducible activity of this promoter was evaluated first in vitro and then in vivo in healthy and uremic rats (n = 30 per group). The vectors (pCMV-Epo) in which Epo expression was directed by a constitutive CMV gene promoter served as control. ANOVA and Student's t-test were used to analyze between- group differences. A high-level expression of Epo was induced by hypoxia in vitro and in vivo. Though both pHRE-Epo and pCMV-Epo corrected anemia, the hematocrit of the pCMV-Epo-treated rats exceeded the normal (P < 0.05), but that of the pHRE-Epo-treated rats didn't. Hypoxia-regulated system of Epo gene expression constructed by fusing Epo to the HRE/CMV promoter and delivered by plasmid intramuscular injection may provide a long-term and stable Epo expression and secretion in vivo to correct the anemia in adenine-induced uremic rats. PMID:22990115
NASA Astrophysics Data System (ADS)
Albacete, Javier L.; Kovchegov, Yuri V.; Taliotis, Anastasios
2009-03-01
We calculate the total cross section for the scattering of a quark-anti-quark dipole on a large nucleus at high energy for a strongly coupled N = 4 super Yang-Mills theory using AdS/CFT correspondence. We model the nucleus by a metric of a shock wave in AdS5. We then calculate the expectation value of the Wilson loop (the dipole) by finding the extrema of the Nambu-Goto action for an open string attached to the quark and antiquark lines of the loop in the background of an AdS5 shock wave. We find two physically meaningful extremal string configurations. For both solutions we obtain the forward scattering amplitude N for the quark dipole-nucleus scattering. We study the onset of unitarity with increasing center-of-mass energy and transverse size of the dipole: we observe that for both solutions the saturation scale Qs is independent of energy/Bjorken-x and depends on the atomic number of the nucleus as Qs˜A1/3. Finally we observe that while one of the solutions we found corresponds to the pomeron intercept of αP = 2 found earlier in the literature, when extended to higher energy or larger dipole sizes it violates the black disk limit. The other solution we found respects the black disk limit and yields the pomeron intercept of αP = 1.5. We thus conjecture that the right pomeron intercept in gauge theories at strong coupling may be αP = 1.5.
Not Available
1992-07-01
The glossary of technical terms was prepared to facilitate the use of the Corrective Action Plan (CAP) issued by OSWER on November 14, 1986. The CAP presents model scopes of work for all phases of a corrective action program, including the RCRA Facility Investigation (RFI), Corrective Measures Study (CMS), Corrective Measures Implementation (CMI), and interim measures. The Corrective Action Glossary includes brief definitions of the technical terms used in the CAP and explains how they are used. In addition, expected ranges (where applicable) are provided. Parameters or terms not discussed in the CAP, but commonly associated with site investigations or remediations are also included.
NASA Astrophysics Data System (ADS)
Holappa, L.; Mursula, K.
2015-10-01
For the time before the space era, our knowledge of the centennial evolution of solar wind (SW) and interplanetary magnetic field (IMF) is based on proxies derived from geomagnetic indices. The reliability of these proxies is dependent on the homogeneity of magnetic field data. In this paper, we study the interhourly (IHV) and interdiurnal (IDV1d) variability indices calculated from the data of two British observatories, Eskdalemuir and Lerwick, and compare them to the corresponding indices of the German Niemegk observatory. We find an excess of about 14 ± 4% (5.8 ± 2%) and 27 ± 10% (15 ± 6%) in the IHV (IDV1d) in the indices of Eskdalemuir and Lerwick in 1935-1969. The timing of this excess accurately coincides with instrument changes made in these observatories, strongly supporting the interpretation that the excess is indeed caused by instrument related inhomogeneities in the data of Eskdalemuir and Lerwick. We show that the detected excess notably modifies the long-term trend of geomagnetic activity and the centennial evolution of IMF strength and solar wind speed estimated using these indices. We note that the detected inhomogeneity problem may not be limited to the data of the two studied observatories but may be quite common to long series of geomagnetic measurements. These results question the reliability of the present measures of the centennial change in solar wind speed and IMF.
NASA Astrophysics Data System (ADS)
Holappa, Lauri; Mursula, Kalevi
2016-07-01
For the time before the space era our knowledge of the centennial evolution of solar wind (SW) and interplanetary magnetic field (IMF) is based on proxies derived from geomagnetic indices. The reliability of these proxies is dependent on the homogeneity of magnetic field data. In this paper we study the interhourly (IHV) and interdiurnal (IDV_{1d}) variability indices calculated from the data of two British observatories, Eskdalemuir and Lerwick, and compare them to the corresponding indices of the German Niemegk observatory. We find an excess of about 14 ± 4% (5.8 ± 2%) and 27 ± 10% (15 ± 6%) in the IHV (IDV_{1d}) in the indices of Eskdalemuir and Lerwick in 1935-1969. The timing of this excess accurately coincides with instrument changes made in these observatories, strongly supporting the interpretation that the excess is indeed caused by instrument related inhomogeneities in the data of Eskdalemuir and Lerwick. We show that the detected excess notably modifies the long-term trend of geomagnetic activity and the centennial evolution of IMF strength and solar wind speed estimated using these indices. We note that the detected inhomogeneity problem may not be limited to the data of the two studied observatories, but may be quite common to long series of geomagnetic measurements. These results question the reliability of the present measures of the centennial change in solar wind speed and IMF.
Fitzpatrick, A.Liam; Kaplan, Jared; /SLAC
2012-02-14
We show that suitably regulated multi-trace primary states in large N CFTs behave like 'in' and 'out' scattering states in the flat-space limit of AdS. Their transition matrix elements approach the exact scattering amplitudes for the bulk theory, providing a natural CFT definition of the flat space S-Matrix. We study corrections resulting from the AdS curvature and particle propagation far from the center of AdS, and show that AdS simply provides an IR regulator that disappears in the flat space limit.
McCord, John
2004-08-01
This report documents the evaluation of the information and data available on the unclassified source term and radionuclide contamination for Central and Western Pahute Mesa: Corrective Action Units (CAUs) 101 and 102.
Nambu-Goto Like Action for the AdS5 × S5 Superstrings in the Generalized Light-Cone Gauge
NASA Astrophysics Data System (ADS)
Itoyama, H.; Oota, T.; Yoshioka, R.
2008-02-01
We reinvestigate the κ-symmetry-fixed Green-Schwarz action in the AdS_5 × S^5 background in a version of the light-cone gauge. In the generalized light-cone gauge, the action has been written in the phase space variables. We convert it into the standard action written in terms of the fields and their derivatives. We thereby obtain a Nambu-Goto-type action which has the correct flat-space limit.
Bias correction with Data Assimilation
NASA Astrophysics Data System (ADS)
Canter, Martin; Barth, Alexander
2015-04-01
With this work, we aim at developping a new method of bias correction using data assimilation. This method is based on the stochastic forcing of a model to correct bias. First, through a preliminary run, we estimate the bias of the model and its possible sources. Then, we establish a forcing term which is directly added inside the model's equations. We create an ensemble of runs and consider the forcing term as a control variable during the assimilation of observations. We then use this analysed forcing term to correct the bias of the model. Since the forcing is added inside the model, it acts as a source term, unlike external forcings such as wind. This procedure has been developed and successfully tested with a twin experiment on a Lorenz 95 model. Indeed, we were able to estimate and recover an artificial bias that had been added into the model. This bias had a spatial structure and was constant through time. The mean and behaviour of the corrected model corresponded to those the reference model. It is currently being applied and tested on the sea ice ocean NEMO LIM model, which is used in the PredAntar project. NEMO LIM is a global and low resolution (2 degrees) coupled model (hydrodynamic model and sea ice model) with long time steps allowing simulations over several decades. Due to its low resolution, the model is subject to bias in area where strong currents are present. We aim at correcting this bias by using perturbed current fields from higher resolution models and randomly generated perturbations. The random perturbations need to be constrained in order to respect the physical properties of the ocean, and not create unwanted phenomena. To construct those random perturbations, we first create a random field with the Diva tool (Data-Interpolating Variational Analysis). Using a cost function, this tool penalizes abrupt variations in the field, while using a custom correlation length. It also decouples disconnected areas based on topography. Then, we filter
Worldsheet scattering in AdS3/CFT2
NASA Astrophysics Data System (ADS)
Sundin, Per; Wulff, Linus
2013-07-01
We confront the recently proposed exact S-matrices for AdS 3/ CFT 2 with direct worldsheet calculations. Utilizing the BMN and Near Flat Space (NFS) expansions for strings on AdS 3 × S 3 × S 3 × S 1 and AdS 3 × S 3 × T 4 we compute both tree-level and one-loop scattering amplitudes. Up to some minor issues we find nice agreement in the tree-level sector. At the one-loop level however we find that certain non-zero tree-level processes, which are not visible in the exact solution, contribute, via the optical theorem, and give an apparent mismatch for certain amplitudes. Furthermore we find that a proposed one-loop modification of the dressing phase correctly reproduces the worldsheet calculation while the standard Hernandez-Lopez phase does not. We also compute several massless to massless processes.
Supersymmetric warped AdS in extended topologically massive supergravity
NASA Astrophysics Data System (ADS)
Deger, N. S.; Kaya, A.; Samtleben, H.; Sezgin, E.
2014-07-01
We determine the most general form of off-shell N=(1,1) supergravity field configurations in three dimensions by requiring that at least one off-shell Killing spinor exists. We then impose the field equations of the topologically massive off-shell supergravity and find a class of solutions whose properties crucially depend on the norm of the auxiliary vector field. These are spacelike-squashed and timelike-stretched AdS3 for the spacelike and timelike norms, respectively. At the transition point where the norm vanishes, the solution is null warped AdS3. This occurs when the coefficient of the Lorentz-Chern-Simons term is related to the AdS radius by μℓ=2. We find that the spacelike-squashed AdS3 can be modded out by a suitable discrete subgroup of the isometry group, yielding an extremal black hole solution which avoids closed timelike curves.
Albacete, Javier L.; Kovchegov, Yuri V.; Taliotis, Anastasios
2009-03-23
We calculate the total cross section for the scattering of a quark-anti-quark dipole on a large nucleus at high energy for a strongly coupled N = 4 super Yang-Mills theory using AdS/CFT correspondence. We model the nucleus by a metric of a shock wave in AdS{sub 5}. We then calculate the expectation value of the Wilson loop (the dipole) by finding the extrema of the Nambu-Goto action for an open string attached to the quark and antiquark lines of the loop in the background of an AdS{sub 5} shock wave. We find two physically meaningful extremal string configurations. For both solutions we obtain the forward scattering amplitude N for the quark dipole-nucleus scattering. We study the onset of unitarity with increasing center-of-mass energy and transverse size of the dipole: we observe that for both solutions the saturation scale Q{sub s} is independent of energy/Bjorken-x and depends on the atomic number of the nucleus as Q{sub s}{approx}A{sup 1/3}. Finally we observe that while one of the solutions we found corresponds to the pomeron intercept of {alpha}{sub P} = 2 found earlier in the literature, when extended to higher energy or larger dipole sizes it violates the black disk limit. The other solution we found respects the black disk limit and yields the pomeron intercept of {alpha}{sub P} = 1.5. We thus conjecture that the right pomeron intercept in gauge theories at strong coupling may be {alpha}{sub P} = 1.5.
Arruda, Valder R; Stedman, Hansell H; Nichols, Timothy C; Haskins, Mark E; Nicholson, Matthew; Herzog, Roland W; Couto, Linda B; High, Katherine A
2005-05-01
In earlier work, we showed that adeno-associated virus-mediated delivery of a Factor IX gene to skeletal muscle by direct intramuscular injection resulted in therapeutic levels of circulating Factor IX in mice. However, achievement of target doses in humans proved impractical because of the large number of injections required. We used a novel intravascular delivery technique to achieve successful transduction of extensive areas of skeletal muscle in a large animal with hemophilia. We provide here the first report of long-term (> 3 years, with observation ongoing), robust Factor IX expression (circulating levels of 4%-14%) by muscle-directed gene transfer in a large animal, resulting in essentially complete correction of the bleeding disorder in hemophilic dogs. The results of this translational study establish an experimental basis for clinical studies of this delivery method in humans with hemophilia B. These findings also have immediate relevance for gene transfer in patients with muscular dystrophy. PMID:15479726
Semiclassical Virasoro blocks from AdS3 gravity
NASA Astrophysics Data System (ADS)
Hijano, Eliot; Kraus, Per; Perlmutter, Eric; Snively, River
2015-12-01
We present a unified framework for the holographic computation of Virasoro conformal blocks at large central charge. In particular, we provide bulk constructions that correctly reproduce all semiclassical Virasoro blocks that are known explicitly from conformal field theory computations. The results revolve around the use of geodesic Witten diagrams, recently introduced in [1], evaluated in locally AdS3 geometries generated by backreaction of heavy operators. We also provide an alternative computation of the heavy-light semiclassical block — in which two external operators become parametrically heavy — as a certain scattering process involving higher spin gauge fields in AdS3; this approach highlights the chiral nature of Virasoro blocks. These techniques may be systematically extended to compute corrections to these blocks and to interpolate amongst the different semiclassical regimes.
NASA Astrophysics Data System (ADS)
Martelli, Dario; Morales, Jose F.
2005-02-01
In the light of the recent Lin, Lunin, Maldacena (LLM) results, we investigate 1/2-BPS geometries in minimal (and next to minimal) supergravity in D = 6 dimensions. In the case of minimal supergravity, solutions are given by fibrations of a two-torus T2 specified by two harmonic functions. For a rectangular torus the two functions are related by a non-linear equation with rare solutions: AdS3 × S3, the pp-wave and the multi-center string. ``Bubbling'', i.e. superpositions of droplets, is accommodated by allowing the complex structure of the T2 to vary over the base. The analysis is repeated in the presence of a tensor multiplet and similar conclusions are reached, with generic solutions describing D1D5 (or their dual fundamental string-momentum) systems. In this framework, the profile of the dual fundamental string-momentum system is identified with the boundaries of the droplets in a two-dimensional plane.
Hu, Yu; Lai, Jinsheng; Wan, Baoquan; Liu, Xingfa; Zhang, Yemao; Zhang, Jiangong; Sun, Dongsheng; Ruan, Guoran; Liu, Enjie; Liu, Gong-Ping; Chen, Chen; Wang, Dao Wen
2016-03-01
Although numerous studies have reported the influence of extremely low frequency magnetic field (ELF-MF) exposure on human health, its effects on cognitive deficits in Alzheimer's disease (AD) have remained under debate. Moreover, the influence of ELF-MF on hyperphosphorylated tau, which is one of the most common pathological hallmarks of AD, has not been reported to date. Therefore, transgenic mice (3xTg) were used in the present study. 3xTg mice, which express an APP/PS1 mutation combined with a tau (P301L) mutation and that develop cognitive deficits at 6 months of age, were subjected to ELF-MF (50Hz, 500μT) exposure or sham exposure daily for 3 months. We discovered that ELF-MF exposure ameliorated cognitive deficits and increased synaptic proteins in 3xTg mice. The protective effects of ELF-MF exposure may have also been caused by the inhibition of apoptosis and/or decreased oxidative stress levels that were observed in the hippocampus tissues of treated mice. Furthermore, tau hyperphosphorylation was decreased in vivo because of ELF-MF exposure, and this decrease was induced by the inhibition of GSK3β and CDK5 activities and activation of PP2Ac. We are the first to report that exposure to ELF-MF can attenuate tau phosphorylation. These findings suggest that ELF-MF exposure could act as a valid therapeutic strategy for ameliorating cognitive deficits and attenuating tau hyperphosphorylation in AD. PMID:26945731
NASA Astrophysics Data System (ADS)
Lorenzini, Sandra; Baroni, Carlo; Fallick, Anthony Edward; Baneschi, Ilaria; Salvatore, Maria Cristina; Zanchetta, Giovanni; Dallai, Luigi
2010-05-01
The stable isotopes geochemistry of carbon and nitrogen provides a powerful tools for investigating in animal dietary patterns and shifts during the past. The signature of C and N isotopes provide direct information about the diet of an individual and its dietary patterns, especially when the dietary sources consist of prey from different trophic levels (i.e. different C and N isotopic composition) (DeNiro and Epstein 1978, Minawaga and Wada 1984, Koch et al. 1994, Hobson 1995). By analyzing the isotopic composition of penguin remains, we present a new detailed Adélie penguin (Pygoscelis adeliae) paleodietary record for the area of Terra Nova Bay (Victoria Land, Ross Sea). Adélie penguins primarily feed on fish (mainly the silverfish Pleuragramma antarcticum) and krill (Euphausia superba, Euphausia cristallorophias) (Ainley 2002, Lorenzini et al. 2009) that belonging to two different trophic levels. Consequently, they are characterized by different isotopic signatures. Specifically, we analyzed 13C/12C and 15N/14N ratios of more than one thousand of modern and fossil Adélie penguin eggshell and guano samples collected from ornithogenic soils (penguin guano-formed) dated back to ≈7,200 years BP (Baroni and Orombelli 1994, Lambert et al. 2002, Baroni and Hall 2004, Hall et al. 2006). The expanded database of stable isotope values obtained from Adélie penguin remains define a detailed paleodietary record with an excellent temporal continuity over all the investigated time period. Our data indicate a significant dietary shift between fish and krill, with a gradual decrease from past to present time in the proportion of fish compared to krill in Adélie penguin diet. From 7200 yrs BP to 2000 yrs BP, δ13C and δ15N values indicate fish as the most eaten prey. The dietary contribution of lower-trophic prey in penguin diet started becoming evident not earlier than 2000 yrs BP, when the δ13C values reveal a mixed diet based on fish and krill consumption. Modern
Kwon, Kye Yoon; Jang, Sun Young; Yoon, Jin Sook
2015-07-01
Paralytic ectropion caused by facial nerve palsy often requires surgical intervention for cornea protection. In this study, the authors intended to investigate the long-term surgical outcome of their surgical technique of correcting paralytic ectropion, which is a combined lateral tarsal strip and minimal temporal permanent tarsorrhaphy. The authors performed a retrospective chart review of patients who underwent paralytic ectropion repair by combined lateral tarsal strip with minimal temporal permanent tarsorrhaphy (5 mm) from January 2010 to December 2012. Patients with at least 1 year of follow-up were included. An analysis of preoperative and postoperative measurements included the extent of lagophthalmos, grade of superficial punctate keratopathy (SPK), and tear break-up time (tBUT). The study included 22 patients and a total of 22 eyes. The lagophthalmos, grade of SPK, and tBUT at both 1 month and 1 year of postoperative follow-up were all significantly improved compared with preoperatively (all P < 0.01). At 1 year after surgery, the mean SPK grade and tBUT were slightly, but not significantly, worse than at 1 month after surgery (P = 0.716 and P = 0.632, retrospectively). Three patients were not satisfied with the aesthetic appearance; however, no patient required additional surgery to enhance eyelid closure because of ectropion recurrence or to reopen the tarsorrhaphy during long-term follow-up. Combined lateral tarsal strip with minimal temporal permanent tarsorrhaphy is a quick, safe, and effective surgical technique for the treatment of lower eyelid paralytic ectropion. It produces minimal cosmetic disfigurement and low morbidity during long-term follow-up. PMID:26086924
Nonholomorphic corrections from three-branes in F theory
NASA Astrophysics Data System (ADS)
de Mello Koch, Robert; Paulin-Campbell, Alastair; Rodrigues, João P.
1999-11-01
We construct solutions of type IIB supergravity corresponding to seven-branes, an O7 plane, and three-branes. By considering a probe moving in this background, with constant coupling and an AdS5 component in its geometry, we are able to reproduce the exact low energy effective action for N=2 super Yang-Mills theory with gauge group SU(2) and Nf=4 massless flavors. After turning on a mass for the flavors we find corrections to the AdS5 geometry. In addition, the coupling shows a power law dependence on the energy scale of the theory. The origin of the power law behavior of the coupling is traced back to instanton corrections. Instanton corrections to the four derivative terms in the low energy effective action are correctly obtained from a probe analysis. We study how these instanton corrections are reflected in the background geometry by calculating the quark-antiquark potential. Finally we consider a solution corresponding to an asymptotically free field theory. Again, the leading form of the four derivative terms in the low energy effective action is in complete agreement with field theory expectations.
Numerical integration of subtraction terms
NASA Astrophysics Data System (ADS)
Seth, Satyajit; Weinzierl, Stefan
2016-06-01
Numerical approaches to higher-order calculations often employ subtraction terms, both for the real emission and the virtual corrections. These subtraction terms have to be added back. In this paper we show that at NLO the real subtraction terms, the virtual subtraction terms, the integral representations of the field renormalization constants and—in the case of initial-state partons—the integral representation for the collinear counterterm can be grouped together to give finite integrals, which can be evaluated numerically. This is useful for an extension towards next-to-next-to-leading order.
NASA Astrophysics Data System (ADS)
Turco, M.; Milelli, M.
2009-09-01
skill scores of two competitive forecast. It is important to underline that the conclusions refer to the analysis of the Piemonte operational alert system, so they cannot be directly taken as universally true. But we think that some of the main lessons that can be derived from this study could be useful for the meteorological community. In details, the main conclusions are the following: - despite the overall improvement in global scale and the fact that the resolution of the limited area models has increased considerably over recent years, the QPF produced by the meteorological models involved in this study has not improved enough to allow its direct use, that is, the subjective HQPF continues to offer the best performance; - in the forecast process, the step where humans have the largest added value with respect to mathematical models, is the communication. In fact the human characterisation and communication of the forecast uncertainty to end users cannot be replaced by any computer code; - eventually, although there is no novelty in this study, we would like to show that the correct application of appropriated statistical techniques permits a better definition and quantification of the errors and, mostly important, allows a correct (unbiased) communication between forecasters and decision makers.
Multi-spike strings in AdS3 with mixed three-form fluxes
NASA Astrophysics Data System (ADS)
Banerjee, Aritra; Sadhukhan, Abhishake
2016-05-01
The string sigma model in AdS3 × S 3 supported by mixed three-form fluxes has recently been proved to be integrable which led to a plethora of work in this background including proposals for S matrix and study of semiclassical string profiles. Motivated by this, in this paper, we present a study of `spiky' strings in this background. We analyze the string profiles in detail and also find the dispersion relation between the charges in the `long' string limit after solving the equations of motion perturbatively upto the leading order in the Neveu-Schwarz flux b. We find that the dispersion for 2 spikes gets corrected by the term -b^2/2 log S. We also discuss the fate of the solution in the limit of pure NS-NS flux.
New massive gravity and AdS(4) counterterms.
Jatkar, Dileep P; Sinha, Aninda
2011-04-29
We show that the recently proposed Dirac-Born-Infeld extension of new massive gravity emerges naturally as a counterterm in four-dimensional anti-de Sitter space (AdS(4)). The resulting on-shell Euclidean action is independent of the cutoff at zero temperature. We also find that the same choice of counterterm gives the usual area law for the AdS(4) Schwarzschild black hole entropy in a cutoff-independent manner. The parameter values of the resulting counterterm action correspond to a c=0 theory in the context of the duality between AdS(3) gravity and two-dimensional conformal field theory. We rewrite this theory in terms of the gauge field that is used to recast 3D gravity as a Chern-Simons theory. PMID:21635026
Higher derivative corrections to BPS black hole attractors in 4d gauged supergravity
NASA Astrophysics Data System (ADS)
Hristov, Kiril; Katmadas, Stefanos; Lodato, Ivano
2016-05-01
We analyze BPS black hole attractors in 4d gauged supergravity in the presence of higher derivative supersymmetric terms, including a Weyl-squared-type action, and determine the resulting corrections to the Bekenstein-Hawking entropy. The near-horizon geometry AdS2×S2 (or other Riemann surface) preserves half of the supercharges in N = 2 supergravity with Fayet-Iliopoulos gauging. We derive a relation between the entropy and the black hole charges that suggests via AdS/CFT how subleading corrections contribute to the supersymmetric index in the dual microscopic picture.
Collins, Doug; Benedict, Chris; Bary, Andy; Cogger, Craig
2015-01-01
The spatial heterogeneity of soil and weed populations poses a challenge to researchers. Unlike aboveground variability, below-ground variability is more difficult to discern without a strategic soil sampling pattern. While blocking is commonly used to control environmental variation, this strategy is rarely informed by data about current soil conditions. Fifty georeferenced sites were located in a 0.65 ha area prior to establishing a long-term field experiment. Soil organic matter (OM) and weed seed bank populations were analyzed at each site and the spatial structure was modeled with semivariograms and interpolated with kriging to map the surface. These maps were used to formulate three strategic blocking patterns and the efficiency of each pattern was compared to a completely randomized design and a west to east model not informed by soil variability. Compared to OM, weeds were more variable across the landscape and had a shorter range of autocorrelation, and models to increase blocking efficiency resulted in less increase in power. Weeds and OM were not correlated, so no model examined improved power equally for both parameters. Compared to the west to east blocking pattern, the final blocking pattern chosen resulted in a 7-fold increase in power for OM and a 36% increase in power for weeds. PMID:26247056
Collins, Doug; Benedict, Chris; Bary, Andy; Cogger, Craig
2015-01-01
The spatial heterogeneity of soil and weed populations poses a challenge to researchers. Unlike aboveground variability, below-ground variability is more difficult to discern without a strategic soil sampling pattern. While blocking is commonly used to control environmental variation, this strategy is rarely informed by data about current soil conditions. Fifty georeferenced sites were located in a 0.65 ha area prior to establishing a long-term field experiment. Soil organic matter (OM) and weed seed bank populations were analyzed at each site and the spatial structure was modeled with semivariograms and interpolated with kriging to map the surface. These maps were used to formulate three strategic blocking patterns and the efficiency of each pattern was compared to a completely randomized design and a west to east model not informed by soil variability. Compared to OM, weeds were more variable across the landscape and had a shorter range of autocorrelation, and models to increase blocking efficiency resulted in less increase in power. Weeds and OM were not correlated, so no model examined improved power equally for both parameters. Compared to the west to east blocking pattern, the final blocking pattern chosen resulted in a 7-fold increase in power for OM and a 36% increase in power for weeds. PMID:26247056
Holographic thermalization with Weyl corrections
NASA Astrophysics Data System (ADS)
Dey, Anshuman; Mahapatra, Subhash; Sarkar, Tapobrata
2016-01-01
We consider holographic thermalization in the presence of a Weyl correction in five dimensional AdS space. We first obtain the Weyl corrected black brane solution perturbatively, up to first order in the coupling. The corresponding AdS-Vaidya like solution is then constructed. This is then used to numerically analyze the time dependence of the two point correlation functions and the expectation values of rectangular Wilson loops in the boundary field theory, and we discuss how the Weyl correction can modify the thermalization time scales in the dual field theory. In this context, the subtle interplay between the Weyl coupling constant and the chemical potential is studied in detail.
Deuteron Electromagnetic Form Factors in AdS/QCD
NASA Astrophysics Data System (ADS)
Lyubovitskij, Valery E.; Gutsche, Thomas; Schmidt, Ivan; Vega, Alfredo
2016-03-01
We extend a soft-wall AdS/QCD approach to a description of deuteron properties. Our framework is based an effective action formulated in terms of AdS fields, which are holographically equivalent to the deuteron and photon fields. This action produces the equation of motion for the deuteron wave function and the Q^2 -dependent electromagnetic current, which are then used to calculate the deuteron electromagnetic form factors and structure functions in the Euclidean region. We show that the predicted deuteron quantities are expressed through a universal function, which is defined by a single scale parameter κ and which has the correct 1/Q^{10} power scaling at large Q^2.
Deuteron Electromagnetic Form Factors in AdS/QCD
NASA Astrophysics Data System (ADS)
Lyubovitskij, Valery E.; Gutsche, Thomas; Schmidt, Ivan; Vega, Alfredo
2016-07-01
We extend a soft-wall AdS/QCD approach to a description of deuteron properties. Our framework is based an effective action formulated in terms of AdS fields, which are holographically equivalent to the deuteron and photon fields. This action produces the equation of motion for the deuteron wave function and the Q^2-dependent electromagnetic current, which are then used to calculate the deuteron electromagnetic form factors and structure functions in the Euclidean region. We show that the predicted deuteron quantities are expressed through a universal function, which is defined by a single scale parameter κ and which has the correct 1/Q^{10} power scaling at large Q^2.
NASA Astrophysics Data System (ADS)
Accomazzi, Alberto; Henneken, E.; Grant, C. S.; Kurtz, M. J.; Di Milia, G.; Luker, J.; Thompson, D. M.; Bohlen, E.; Murray, S. S.
2011-05-01
ADS Labs is a platform that ADS is introducing in order to test and receive feedback from the community on new technologies and prototype services. Currently, ADS Labs features a new interface for abstract searches, faceted filtering of results, visualization of co-authorship networks, article-level recommendations, and a full-text search service. The streamlined abstract search interface provides a simple, one-box search with options for ranking results based on a paper relevancy, freshness, number of citations, and downloads. In addition, it provides advanced rankings based on collaborative filtering techniques. The faceted filtering interface allows users to narrow search results based on a particular property or set of properties ("facets"), allowing users to manage large lists and explore the relationship between them. For any set or sub-set of records, the co-authorship network can be visualized in an interactive way, offering a view of the distribution of contributors and their inter-relationships. This provides an immediate way to detect groups and collaborations involved in a particular research field. For a majority of papers in Astronomy, our new interface will provide a list of related articles of potential interest. The recommendations are based on a number of factors, including text similarity, citations, and co-readership information. The new full-text search interface allows users to find all instances of particular words or phrases in the body of the articles in our full-text archive. This includes all of the scanned literature in ADS as well as a select portion of the current astronomical literature, including ApJ, ApJS, AJ, MNRAS, PASP, A&A, and soon additional content from Springer journals. Fulltext search results include a list of the matching papers as well as a list of "snippets" of text highlighting the context in which the search terms were found. ADS Labs is available at http://adslabs.org
NASA Astrophysics Data System (ADS)
Costa, Miguel S.; Greenspan, Lauren; Oliveira, Miguel; Penedones, João; Santos, Jorge E.
2016-06-01
We consider solutions in Einstein-Maxwell theory with a negative cosmological constant that asymptote to global AdS 4 with conformal boundary {S}2× {{{R}}}t. At the sphere at infinity we turn on a space-dependent electrostatic potential, which does not destroy the asymptotic AdS behaviour. For simplicity we focus on the case of a dipolar electrostatic potential. We find two new geometries: (i) an AdS soliton that includes the full backreaction of the electric field on the AdS geometry; (ii) a polarised neutral black hole that is deformed by the electric field, accumulating opposite charges in each hemisphere. For both geometries we study boundary data such as the charge density and the stress tensor. For the black hole we also study the horizon charge density and area, and further verify a Smarr formula. Then we consider this system at finite temperature and compute the Gibbs free energy for both AdS soliton and black hole phases. The corresponding phase diagram generalizes the Hawking-Page phase transition. The AdS soliton dominates the low temperature phase and the black hole the high temperature phase, with a critical temperature that decreases as the external electric field increases. Finally, we consider the simple case of a free charged scalar field on {S}2× {{{R}}}t with conformal coupling. For a field in the SU(N ) adjoint representation we compare the phase diagram with the above gravitational system.
Aslanides, Ioannis M; Georgoudis, Panagiotis N; Selimis, Vasilis D; Mukherjee, Achyut N
2015-01-01
Purpose We wanted to compare the outcomes of single-step modified transepithelial photorefractive keratectomy (tPRK) termed a SCHWIND all surface laser ablation (ASLA) versus conventional alcohol-assisted photorefractive keratectomy (PRK) and laser-assisted in situ keratomileusis (LASIK) for the correction of higher myopia of 6.00 diopters (D) or more, in an area with high risk of haze due to high intensity of sunlight. Methods We used a prospective interventional cohort with matched retrospective control groups. Patients with >6 D myopia and <3.5 D of astigmatism were included. All treatments were performed with the SCHWIND Amaris system using aspheric ablation profiles. Mitomycin C was used in all PRK and ASLA cases. Outcomes were postoperative refraction, visual acuity, stability, and complications. The follow-up period was up to 12 months. Results In total, 101 eyes were included after exclusions. Mean preoperative spherical equivalent refraction was -7.9 D, -8.2 D, and -7.4 D in the ASLA (n=41), PRK (n=29), and LASIK (n=31) groups. Mean postoperative spherical equivalent at 12 months postoperatively was −0.1 (standard deviation [SD]: 0.34), −0.2 (SD: 0.59), and −0.08 (SD: 0.36) in the ASLA, PRK, and LASIK groups, with 91.4%, 85.7%, and 83.9% within 0.5 D of target, respectively. Refractive outcomes and regression at 12 months did not vary among groups (P>0.05). Mean logMAR (logarithm of the minimum angle of resolution) uncorrected distance visual acuity at 12 months was 0.00 (SD: 0.05), 0.06 (SD: 0.1), and 0.05 (SD: 0.09) in the ASLA, PRK, and LASIK groups, with significantly better vision in the tPRK group versus LASIK (P=0.01) and PRK (P=0.01) groups. Conclusion ASLA (SCHWIND) tPRK with mitomycin C for high myopia demonstrates comparable refractive outcomes to LASIK and PRK, with relatively favorable visual acuity outcomes. There was no increased incidence of haze in the ASLA group. PMID:25565766
Value Added and Other Related Matters.
ERIC Educational Resources Information Center
Whitla, Dean K.
The term "value added" refers to the assessment of the amount of learning that takes place during the college years. Two experiments, Value Added I and Value Added II, attempted to measure college students' attainment of eight liberal education objectives: (1) writing ability; (2) analytical ability; (3) sensitivity to ethics, morals, and values;…
Molina-Estevez, F Javier; Nowrouzi, Ali; Lozano, M Luz; Galy, Anne; Charrier, Sabine; von Kalle, Christof; Guenechea, Guillermo; Bueren, Juan A; Schmidt, Manfred
2015-01-01
Fanconi anemia is a DNA repair-deficiency syndrome mainly characterized by cancer predisposition and bone marrow failure. Trying to restore the hematopoietic function in these patients, lentiviral vector-mediated gene therapy trials have recently been proposed. However, because no insertional oncogenesis studies have been conducted so far in DNA repair-deficiency syndromes such as Fanconi anemia, we have carried out a genome-wide screening of lentiviral insertion sites after the gene correction of Fanca(-/-) hematopoietic stem cells (HSCs), using LAM-PCR and 454-pyrosequencing. Our studies first demonstrated that transduction of Fanca(-/-) HSCs with a lentiviral vector designed for clinical application efficiently corrects the phenotype of Fanconi anemia repopulating cells without any sign of toxicity. The identification of more than 6,500 insertion sites in primary and secondary recipients showed a polyclonal pattern of reconstitution, as well as a continuous turnover of corrected Fanca(-/-) HSC clones, without evidences of selection towards specific common integration sites. Taken together our data show, for the first time in a DNA repair-deficiency syndrome, that lentiviral vector-mediated gene therapy efficiently corrects the phenotype of affected HSCs and promotes a healthy pattern of clonal turnover in vivo. These studies will have a particular impact in the development of new gene therapy trials in patients affected by DNA repair syndromes, particularly in Fanconi anemia. PMID:26415575
NASA Astrophysics Data System (ADS)
Taylor, F. W.; Thirumalai, K.; Lavier, L. L.; Frohlich, C.; Shen, C.; WU, C.; Sun, H.; Papabatu, A. K.
2013-12-01
The processes of forearc deformation and their relation to the megathrust earthquake cycle provide critical insights regarding longer-term arc tectonic evolution and the earthquake cycle itself. At the Western Solomon Islands arc, Ranongga and other islands sit over the seismogenic megathrust as close as 4 km from the trench where the Australian plate converges at ~80-100 mm/yr. Coral reefs fringe the coasts and record the relative sea level changes accompanying both long-term tectonic uplift and the shorter-term earthquake cycle. The AD 2007 Mw 8.1 megathrust rupture zone dips from 1-2 km to ~25 km deep beneath islands and caused uplift that we measured at coasts along a profile normal to the arc trend. Vertical components of the 2007 displacement show the expected fairly smooth uplift profile typical of elastic strain release. In contrast, along the same profile the amounts of longer-term net uplift of the mid-Holocene (~6 ka) coral shoreline are more variable. Likewise, the elevations of individual coral paleo-shorelines recording a series of individual uplifts (as young as 600 yr old with ~2.25 m uplift) also indicate variable amounts of uplift along the profile when compared to the 2007 coseismic uplift. For 50 -100 yr before 2007, all sites along the same profile subsided at rates on the order of 1-3 cm/yr, all of which equaled or exceeded the upward growth rates of corals. However, the amounts of pre-2007 subsidence are highly variable along the profile and do not conform well to the smoother profile of the 2007 displacements. Where total uplift since the mid-Holocene is smaller, pre-2007 subsidence and 2007 uplift may be relatively large. Where total uplift since the mid-Holocene is larger, 2007 coseismic uplift may be large while pre-2007 subsidence is relatively small. Therefore, the differences in longer-term uplift rates appear tied to variable subsidence during the interseismic period rather than being primarily a coseismic phenomenon. Furthermore
Lorentzian AdS geometries, wormholes, and holography
Arias, Raul E.; Silva, Guillermo A.; Botta Cantcheff, Marcelo
2011-03-15
We investigate the structure of two-point functions for the quantum field theory dual to an asymptotically Lorentzian Anti de Sitter (AdS) wormhole. The bulk geometry is a solution of five-dimensional second-order Einstein-Gauss-Bonnet gravity and causally connects two asymptotically AdS spacetimes. We revisit the Gubser-Klebanov-Polyakov-Witten prescription for computing two-point correlation functions for dual quantum field theories operators O in Lorentzian signature and we propose to express the bulk fields in terms of the independent boundary values {phi}{sub 0}{sup {+-}} at each of the two asymptotic AdS regions; along the way we exhibit how the ambiguity of normalizable modes in the bulk, related to initial and final states, show up in the computations. The independent boundary values are interpreted as sources for dual operators O{sup {+-}} and we argue that, apart from the possibility of entanglement, there exists a coupling between the degrees of freedom living at each boundary. The AdS{sub 1+1} geometry is also discussed in view of its similar boundary structure. Based on the analysis, we propose a very simple geometric criterion to distinguish coupling from entanglement effects among two sets of degrees of freedom associated with each of the disconnected parts of the boundary.
Inugami, A.; Kanno, I.; Uemura, K.; Shishido, F.; Murakami, M.; Tomura, N.; Fujita, H.; Higano, S.
1988-12-01
The radioisotope distribution following intravenous injection of 99mTc-labeled hexamethylpropyleneamine oxime (HM-PAO) in the brain was measured by single photon emission computed tomography (SPECT) and corrected for the nonlinearity caused by differences in net extraction. The linearization correction was based on a three compartment model, and it required a region of reference to normalize the SPECT image in terms of regional cerebral blood flow distribution. Two different regions of reference, the cerebellum and the whole brain, were tested. The uncorrected and corrected HM-PAO images were compared with cerebral blood flow (CBF) image measured by the C VO2 inhalation steady state method and positron emission tomography (PET). The relationship between uncorrected HM-PAO and PET-CBF showed a correlation coefficient of 0.85 but tended to saturate at high CBF values, whereas it was improved to 0.93 after the linearization correction. The whole-brain normalization worked just as well as normalization using the cerebellum. This study constitutes a validation of the linearization correction and it suggests that after linearization the HM-PAO image may be scaled to absolute CBF by employing a global hemispheric CBF value as measured by the nontomographic TTXe clearance method.
Smeared antibranes polarise in AdS
NASA Astrophysics Data System (ADS)
Gautason, Fridrik Freyr; Truijen, Brecht; Van Riet, Thomas
2015-07-01
In the recent literature it has been questioned whether the local backreaction of antibranes in flux throats can induce a perturbative brane-flux decay. Most evidence for this can be gathered for D6 branes and D p branes smeared over 6 - p compact directions, in line with the absence of finite temperature solutions for these cases. The solutions in the literature have flat worldvolume geometries and non-compact transversal spaces. In this paper we consider what happens when the worldvolume is AdS and the transversal space is compact. We show that in these circumstances brane polarisation smoothens out the flux singularity, which is an indication that brane-flux decay is prevented. This is consistent with the fact that the cosmological constant would be less negative after brane-flux decay. Our results extend recent results on AdS7 solutions from D6 branes to AdS p+1 solutions from D p branes. We show that supersymmetry of the AdS solutions depend on p non-trivially.
Liew, Steven; Scamp, Terrence; de Maio, Mauricio; Halstead, Michael; Johnston, Nicole; Silberberg, Michael; Rogers, John D.
2016-01-01
Background There is increasing interest among patients and plastic surgeons for alternatives to rhinoplasty, a common surgical procedure performed in Asia. Objectives To evaluate the safety, efficacy, and longevity of a hyaluronic acid filler in the correction of aesthetically detracting or deficient features of the Asian nose. Methods Twenty-nine carefully screened Asian patients had their noses corrected with the study filler (Juvéderm VOLUMA [Allergan plc, Dublin, Ireland] with lidocaine injectable gel), reflecting individualized treatment goals and utilizing a standardized injection procedure, and were followed for over 12 months. Results A clinically meaningful correction (≥1 grade improvement on the Assessment of Aesthetic Improvement Scale) was achieved in 27 (93.1%) patients at the first follow-up visit. This was maintained in 28 (96.6%) patients at the final visit, based on the independent assessments of a central non-injecting physician and the patients. At this final visit, 23 (79.3%) patients were satisfied or very satisfied with the study filler and 25 (86.2%) would recommend it to others. In this small series of patients, there were no serious adverse events (AEs), with all treatment-related AEs being mild to moderate, transient injection site reactions, unrelated to the study filler. Conclusions Using specific eligibility criteria, individualized treatment goals, and a standardized injection procedure, the study filler corrected aesthetically detracting or deficient features of the Asian nose, with the therapeutic effects lasting for over 12 months, consistent with a high degree of patient satisfaction. This study supports the safety and efficacy of this HA filler for specific nose augmentation procedures in selected Asian patients. Level of Evidence: 3 Therapeutic PMID:27301371
Randall-Sundrum II cosmology, AdS/CFT, and the bulk black hole
NASA Astrophysics Data System (ADS)
Hebecker, A.; March-Russell, J.
2001-08-01
We analyse the cosmology of a brane world model where a single brane carrying the standard model fields forms the boundary of a 5-dimensional AdS bulk (the Randall-Sundrum II scenario). We focus on the thermal radiation of bulk gravitons, the formation of the bulk black hole, and the holographic AdS/CFT definition of the RSII theory. Our detailed calculation of bulk radiation reduces previous estimates to a phenomenologically acceptable, although potentially visible level. In late cosmology, in which the Friedmann equation depends linearly on the energy density /ρ, only about 1% of energy density is lost to the black hole or, equivalently, to the `dark radiation' (Ωd,N~=0.01 at nucleosynthesis). The preceding, unconventional ρ2 period can produce up to 10% dark radiation (Ωd,N<~0.1). The AdS/CFT correspondence provides an equivalent description of late RSII cosmology. We show how the AdS/CFT formulation can reproduce the ρ2 correction to the standard treatment at low matter density. However, the 4-dimensional effective theory of CFT /+ gravity breaks down due to higher curvature terms for energy densities where ρ2 behaviour in the Friedmann equation is usually predicted. We emphasize that, in going beyond this energy density, the microscopic formulation of the theory becomes essential. For example, the pure AdS5 and string-motivated AdS5×S5 definitions differ in their cosmological implications.
Higher-derivative superparticle in AdS3 space
NASA Astrophysics Data System (ADS)
Kozyrev, Nikolay; Krivonos, Sergey; Lechtenfeld, Olaf
2016-03-01
Employing the coset approach we construct component actions for a superparticle moving in AdS3 with N =(2 ,0 ), D =3 supersymmetry partially broken to N =2 , d =1 . These actions may contain higher time-derivative terms, which are chosen to possess the same (super)symmetries as the free superparticle. In terms of the nonlinear-realization superfields, the component actions always take a simpler form when written in terms of covariant Cartan forms. We also consider in detail the reduction to the nonrelativistic case and construct the corresponding action of a Newton-Hooke superparticle and its higher-derivative generalizations. The structure of these higher time-derivative generalizations is completely fixed by invariance under the supersymmetric Newton-Hooke algebra extended by two central charges.
Bernstein, D.M.; Rogers, R.A.; Sepulveda, R.; Kunzendorf, P.; Bellmann, B.; Ernst, H.; Creutzenberg, O.; Phillips, J.I.
2015-02-15
This study was designed to provide an understanding of the biokinetics and potential toxicology in the lung and pleura following inhalation of brake dust following short term exposure in rats. The deposition, translocation and pathological response of brake-dust derived from brake pads manufactured with chrysotile were evaluated in comparison to the amphibole, crocidolite asbestos. Rats were exposed by inhalation 6 h/day for 5 days to either brake-dust obtained by sanding of brake-drums manufactured with chrysotile, a mixture of chrysotile and the brake-dust or crocidolite asbestos. The chrysotile fibers were relatively biosoluble whereas the crocidolite asbestos fibers persisted through the life-time of the animal. This was reflected in the lung and the pleura where no significant pathological response was observed at any time point in the brake dust or chrysotile/brake dust exposure groups through 365 days post exposure. In contrast, crocidolite asbestos produced a rapid inflammatory response in the lung parenchyma and the pleura, inducing a significant increase in fibrotic response in both of these compartments. Crocidolite fibers were observed embedded in the diaphragm with activated mesothelial cells immediately after cessation of exposure. While no chrysotile fibers were found in the mediastinal lymph nodes, crocidolite fibers of up to 35 μm were observed. These results provide support that brake-dust derived from chrysotile containing brake drums would not initiate a pathological response in the lung or the pleural cavity following short term inhalation. - Highlights: • Evaluated brake dust w/wo added chrysotile in comparison to crocidolite asbestos. • Persistence, translocation, pathological response in the lung and pleural cavity. • Chrysotile cleared rapidly from the lung while the crocidolite asbestos persisted. • No significant pathology in lung or pleural cavity observed at any time point in the brake-dust groups. • Crocidolite quickly
Small black holes in global AdS spacetime
NASA Astrophysics Data System (ADS)
Jokela, Niko; Pönni, Arttu; Vuorinen, Aleksi
2016-04-01
We study the properties of two-point functions and quasinormal modes in a strongly coupled field theory holographically dual to a small black hole in global anti-de Sitter spacetime. Our results are seen to smoothly interpolate between known limits corresponding to large black holes and thermal AdS space, demonstrating that the Son-Starinets prescription works even when there is no black hole in the spacetime. Omitting issues related to the internal space, the results can be given a field theory interpretation in terms of the microcanonical ensemble, which provides access to energy densities forbidden in the canonical description.
Plouff, Donald
2000-01-01
Gravity observations are directly made or are obtained from other sources by the U.S. Geological Survey in order to prepare maps of the anomalous gravity field and consequently to interpret the subsurface distribution of rock densities and associated lithologic or geologic units. Observations are made in the field with gravity meters at new locations and at reoccupations of previously established gravity "stations." This report illustrates an interactively-prompted series of steps needed to convert gravity "readings" to values that are tied to established gravity datums and includes computer programs to implement those steps. Inasmuch as individual gravity readings have small variations, gravity-meter (instrument) drift may not be smoothly variable, and acommodations may be needed for ties to previously established stations, the reduction process is iterative. Decision-making by the program user is prompted by lists of best values and graphical displays. Notes about irregularities of topography, which affect the value of observed gravity but are not shown in sufficient detail on topographic maps, must be recorded in the field. This report illustrates ways to record field notes (distances, heights, and slope angles) and includes computer programs to convert field notes to gravity terrain corrections. This report includes approaches that may serve as models for other applications, for example: portrayal of system flow; style of quality control to document and validate computer applications; lack of dependence on proprietary software except source code compilation; method of file-searching with a dwindling list; interactive prompting; computer code to write directly in the PostScript (Adobe Systems Incorporated) printer language; and high-lighting the four-digit year on the first line of time-dependent data sets for assured Y2K compatibility. Computer source codes provided are written in the Fortran scientific language. In order for the programs to operate, they first
1/N correction in the D3-brane description of a circular Wilson loop at strong coupling
NASA Astrophysics Data System (ADS)
Buchbinder, E. I.; Tseytlin, A. A.
2014-06-01
We compute the one-loop correction to the probe D3-brane action in AdS5×S5 expanded around the classical Drukker-Fiol solution ending on a circle at the boundary. It is essentially the logarithm of the one-loop partition function of an Abelian N=4 vector multiplet in AdS2×S2 geometry. This one-loop correction should be describing the subleading 1/N term in the expectation value of circular Wilson loop in the totally symmetric rank k representation in SU(N) supersymmetric Yang-Mills theory at strong coupling. In the limit 1≪k≪N when the circular Wilson loop expectation values for the symmetric representation and for the product of k fundamental representations are expected to match, we find that this one-loop D3-brane correction agrees with the gauge theory result for the k-fundamental case.
Heat kernels on cone of AdS2 and k-wound circular Wilson loop in AdS5 × S5 superstring
NASA Astrophysics Data System (ADS)
Bergamin, R.; Tseytlin, A. A.
2016-04-01
We compute the one-loop world-sheet correction to partition function of {{AdS}}5× {{{S}}}5 superstring that should be representing k-fundamental circular Wilson loop in planar limit. The 2d metric of the minimal surface ending on k-wound circle at the boundary is that of a cone of AdS2 with deficit 2π (1-k). We compute the determinants of 2d fluctuation operators by first constructing heat kernels of scalar and spinor Laplacians on the cone using the Sommerfeld formula. The final expression for the k-dependent part of the one-loop correction has simple integral representation but is different from earlier results.
Fermions Tunnelling from Black String and Kerr AdS Black Hole with Consideration of Quantum Gravity
NASA Astrophysics Data System (ADS)
Li, Zhong-hua; Zhang, Li-mei
2016-01-01
In this paper, using the Hamilton-Jacobi Ansatz, we discuss the tunnelling of fermions when effects of quantum gravity are taken into account. We investigate two cases, black string and Kerr AdS black hole. For black string, the uncharged and un-rotating case, we find that the correction of Hawking temperature is only affected by the mass of emitted fermions and the quantum gravitational corrections slow down the increases of the temperature, which naturally leads to remnants left in the evaporation. For another case, the Kerr AdS black hole, we find that the quantum gravitational corrections are not only determined by the mass of the emitted fermions but also affected by the rotating properties of the AdS black hole. So with consideration of the quantum gravity corrections, an offset around the standard temperature always exists.
Peter Martian
2009-05-01
This report documents the evaluation of the information and data available on the unclassified source term and radionuclide contamination for CAU 97: Yucca Flat/Climax Mine. The total residual inventory of radionuclides associated with one or more tests is known as the radiologic source term (RST). The RST is comprised of radionuclides in water, glass, or other phases or mineralogic forms. The hydrologic source term (HST) of an underground nuclear test is the portion of the total RST that is released into the groundwater over time following the test. In this report, the HST represents radionuclide release some time after the explosion and does not include the rapidly evolving mechanical, thermal, and chemical processes during the explosion. The CAU 97: Yucca Flat/Climax Mine has many more detonations and a wider variety of settings to consider compared to other CAUs. For instance, the source term analysis and evaluation performed for CAUs 101 and 102: Central and Western Pahute Mesa and CAU 98: Frenchman Flat did not consider vadose zone attenuation because many detonations were located near or below the water table. However, the large number of Yucca Flat/Climax Mine tests and the location of many tests above the water table warrant a more robust analysis of the unsaturated zone.
Leica ADS40 Sensor for Coastal Multispectral Imaging
NASA Technical Reports Server (NTRS)
Craig, John C.
2007-01-01
The Leica ADS40 Sensor as it is used for coastal multispectral imaging is presented. The contents include: 1) Project Area Overview; 2) Leica ADS40 Sensor; 3) Focal Plate Arrangements; 4) Trichroid Filter; 5) Gradient Correction; 6) Image Acquisition; 7) Remote Sensing and ADS40; 8) Band comparisons of Satellite and Airborne Sensors; 9) Impervious Surface Extraction; and 10) Impervious Surface Details.
Bending AdS waves with new massive gravity
NASA Astrophysics Data System (ADS)
Ayón-Beato, Eloy; Giribet, Gaston; Hassaïne, Mokhtar
2009-05-01
We study AdS-waves in the three-dimensional new theory of massive gravity recently proposed by Bergshoeff, Hohm, and Townsend. The general configuration of this type is derived and shown to exhibit different branches, with different asymptotic behaviors. In particular, for the special fine tuning m2 = ±1/(2l2), solutions with logarithmic fall-off arise, while in the range m2 > -1/(2l2), spacetimes with Schrödinger isometry group are admitted as solutions. Spacetimes that are asymptotically AdS3, both for the Brown-Henneaux and for the weakened boundary conditions, are also identified. The metric function that characterizes the profile of the AdS-wave behaves as a massive excitation on the spacetime, with an effective mass given by meff2 = m2-1/(2l2). For the critical value m2 = -1/(2l2), the value of the effective mass precisely saturates the Breitenlohner-Freedman bound for the AdS3 space where the wave is propagating on. The analogies with the AdS-wave solutions of topologically massive gravity are also discussed. Besides, we consider the coupling of both massive deformations to Einstein gravity and find the exact configurations for the complete theory, discussing all the different branches exhaustively. One of the effects of introducing the Chern-Simons gravitational term is that of breaking the degeneracy in the effective mass of the generic modes of pure New Massive Gravity, producing a fine structure due to parity violation. Another effect is that the zoo of exact logarithmic specimens becomes considerably enlarged.
Ultraviolet asymptotics and singular dynamics of AdS perturbations
NASA Astrophysics Data System (ADS)
Craps, Ben; Evnin, Oleg; Vanhoof, Joris
2015-10-01
Important insights into the dynamics of spherically symmetric AdS-scalar field perturbations can be obtained by considering a simplified time-averaged theory accurately describing perturbations of amplitude ɛ on time-scales of order 1/ ɛ 2. The coefficients of the time-averaged equations are complicated expressions in terms of the AdS scalar field mode functions, which are in turn related to the Jacobi polynomials. We analyze the behavior of these coefficients for high frequency modes. The resulting asymptotics can be useful for understanding the properties of the finite-time singularity in solutions of the time-averaged theory recently reported in the literature. We highlight, in particular, the gauge dependence of this asymptotics, with respect to the two most commonly used gauges. The harsher growth of the coefficients at large frequencies in higher-dimensional AdS suggests strengthening of turbulent instabilities in higher dimensions. In the course of our derivations, we arrive at recursive relations for the coefficients of the time-averaged theory that are likely to be useful for evaluating them more efficiently in numerical simulations.
Peter Martian
2009-08-01
This report documents the evaluation of the information and data available on the unclassified source term and radionuclide contamination for CAU 97: Yucca Flat/Climax Mine. The total residual inventory of radionuclides associated with one or more tests is known as the radiologic source term (RST). The RST is comprised of radionuclides in water, glass, or other phases or mineralogic forms. The hydrologic source term (HST) of an underground nuclear test is the portion of the total RST that is released into the groundwater over time following the test. In this report, the HST represents radionuclide release some time after the explosion and does not include the rapidly evolving mechanical, thermal, and chemical processes during the explosion. The CAU 97: Yucca Flat/Climax Mine has many more detonations and a wider variety of settings to consider compared to other CAUs. For instance, the source term analysis and evaluation performed for CAUs 101 and 102: Central and Western Pahute Mesa and CAU 98: Frenchman Flat did not consider vadose zone attenuation because many detonations were located near or below the water table. However, the large number of Yucca Flat/Climax Mine tests and the location of many tests above the water table warrant a more robust analysis of the unsaturated zone. The purpose of this report is to develop and document conceptual models of the Yucca Flat/Climax Mine HST for use in implementing source terms for the Yucca Flat/Climax Mine models. This document presents future plans to incorporate the radionuclide attenuation mechanisms due to unsaturated/multiphase flow and transport within the Yucca Flat CAU scale modeling. The important processes that influence radionuclide migration for the unsaturated and saturated tests in alluvial, volcanic, and carbonate settings are identified. Many different flow and transport models developed by Lawrence Livermore National Laboratory (LLNL) and Los Alamos National Laboratory (LANL), including original
Falahati, Farshad; Ferreira, Daniel; Soininen, Hilkka; Mecocci, Patrizia; Vellas, Bruno; Tsolaki, Magda; Kłoszewska, Iwona; Lovestone, Simon; Eriksdotter, Maria; Wahlund, Lars-Olof; Simmons, Andrew; Westman, Eric
2016-03-01
The similarity of atrophy patterns in Alzheimer's disease (AD) and in normal aging suggests age as a confounding factor in multivariate models that use structural magnetic resonance imaging (MRI) data. To study the effect and compare different age correction approaches on AD diagnosis and prediction of mild cognitive impairment (MCI) progression as well as investigate the characteristics of correctly and incorrectly classified subjects. Data from two multi-center cohorts were included in the study [AD = 297, MCI = 445, controls (CTL) = 340]. 34 cortical thickness and 21 subcortical volumetric measures were extracted from MRI. The age correction approaches involved: using age as a covariate to MRI-derived measures and linear detrending of age-related changes based on CTL measures. Orthogonal projections to latent structures was used to discriminate between AD and CTL subjects, and to predict MCI progression to AD, up to 36-months follow-up. Both age correction approaches improved models' quality in terms of goodness of fit and goodness of prediction, as well as classification and prediction accuracies. The observed age associations in classification and prediction results were effectively eliminated after age correction. A detailed analysis of correctly and incorrectly classified subjects highlighted age associations in other factors: ApoE genotype, global cognitive impairment and gender. The two methods for age correction gave similar results and show that age can partially masks the influence of other aspects such as cognitive impairment, ApoE-e4 genotype and gender. Age-related brain atrophy may have a more important association with these factors than previously believed. PMID:26440606
The AdS particle [rapid communication
NASA Astrophysics Data System (ADS)
Ghosh, Subir
2005-09-01
In this Letter we have considered a relativistic Nambu-Goto model for a particle in AdS metric. With appropriate gauge choice to fix the reparameterization invariance, we recover the previously discussed [S. Ghosh, P. Pal, Phys. Lett. B 618 (2005) 243, arxiv:hep-th/0502192] "exotic oscillator". The Snyder algebra and subsequently the κ-Minkowski spacetime are also derived. Lastly we comment on the impossibility of constructing a non-commutative spacetime in the context of open string where only a curved target space is introduced.
Probing crunching AdS cosmologies
NASA Astrophysics Data System (ADS)
Kumar, S. Prem; Vaganov, Vladislav
2016-02-01
Holographic gravity duals of deformations of CFTs formulated on de Sitter spacetime contain FRW geometries behind a horizon, with cosmological big crunch singularities. Using a specific analytically tractable solution within a particular single scalar truncation of {N}=8 supergravity on AdS4, we first probe such crunching cosmologies with spacelike radial geodesics that compute spatially antipodal correlators of large dimension boundary operators. At late times, the geodesics lie on the FRW slice of maximal expansion behind the horizon. The late time two-point functions factorise, and when transformed to the Einstein static universe, they exhibit a temporal non-analyticity determined by the maximal value of the scale factor ã max. Radial geodesics connecting antipodal points necessarily have de Sitter energy Ɛ ≲ ã max, while geodesics with Ɛ > ã max terminate at the crunch, the two categories of geodesics being separated by the maximal expansion slice. The spacelike crunch singularity is curved "outward" in the Penrose diagram for the deformed AdS backgrounds, and thus geodesic limits of the antipodal correlators do not directly probe the crunch. Beyond the geodesic limit, we point out that the scalar wave equation, analytically continued into the FRW patch, has a potential which is singular at the crunch along with complex WKB turning points in the vicinity of the FRW crunch. We then argue that the frequency space Green's function has a branch point determined by ã max which corresponds to the lowest quasinormal frequency.
NASA Astrophysics Data System (ADS)
Pranowo, Harno D.; Rode, Bernd M.
2000-03-01
A canonical ensemble Monte Carlo simulation was performed for Cu2+ in 18.57% aqueous ammonia solution at a temperature of 293.16 K, using ab initio pair potentials and three-body potentials for Cu-H2O-H2O, Cu-H2O-NH3 and Cu-NH3-NH3 interactions. The first solvation shell consists of three water and three ammonia molecules, and the second shell of 11.6 water and 10.2 ammonia molecules. The structure of the solvated ion is discussed in terms of radial distribution functions, coordination number, and angular distributions.
NASA Technical Reports Server (NTRS)
Waegell, Mordecai J.; Palacios, David M.
2011-01-01
Jitter_Correct.m is a MATLAB function that automatically measures and corrects inter-frame jitter in an image sequence to a user-specified precision. In addition, the algorithm dynamically adjusts the image sample size to increase the accuracy of the measurement. The Jitter_Correct.m function takes an image sequence with unknown frame-to-frame jitter and computes the translations of each frame (column and row, in pixels) relative to a chosen reference frame with sub-pixel accuracy. The translations are measured using a Cross Correlation Fourier transformation method in which the relative phase of the two transformed images is fit to a plane. The measured translations are then used to correct the inter-frame jitter of the image sequence. The function also dynamically expands the image sample size over which the cross-correlation is measured to increase the accuracy of the measurement. This increases the robustness of the measurement to variable magnitudes of inter-frame jitter
The Corrected Eta-Squared Coefficient: A Value Added Approach.
ERIC Educational Resources Information Center
Barnette, J. Jackson; McLean, James E.
Eta-Squared (ES) is often used as a measure of strength of association of an effect, a measure often associated with effect size. It is also considered the proportion of total variance accounted for by an independent variable. It is simple to compute and interpret. However, it has one critical weakness cited by several authors (C. Huberty, 1994;…
Li, Yuman; Wang, Xinfang; Lv, Qing; Wang, Jing; Yang, YaLi; He, Lin; Yuan, Li; Zhang, Li; Xie, Mingxing
2016-01-01
Abstract Right ventricular (RV) and left ventricular (LV) dysfunction is an important determinant of poor clinical status in repaired patients with tetralogy of Fallot (TOF). The purpose of our study is to assess the impact of surgical repair on short-term RV and LV function by 2-dimensional speckle tracking echocardiography (STE). Sixty-seven patients (median age 12 months) with TOF before and 6 months after repair and 35 healthy subjects were studied. The patients were divided into the younger (age at surgery ≤12 months) and older (age at surgery >12 months) subgroups. RV and LV global longitudinal systolic strain and strain rate (SR), and LV global circumferential and radial systolic strain and SR were measured by STE. After repair, RV longitudinal strain and SR increased in the younger patients, whereas RV longitudinal SR was decreased in the older patients. LV deformation parameters were unchanged in all patients. In the multivariate analysis, patients with better RV and LV deformation parameters preoperatively were identified to have better RV and LV strain and SR postoperatively (P < 0.05 for all). The surgical approach of the pulmonary valve ring was predictive of RV and LV systolic function postoperatively (P < 0.05 for all). After TOF repair, short-term RV function improvement is identified in the younger but not in the older patients, whereas LV function is unchanged in all patients. The preoperative RV and LV deformational indices are the determinant of postoperative biventricular function improvement. STE appears to be a valuable tool for assessment of biventricular function after congenital heart disease surgery. PMID:27495064
Kundashev, U K; Zurdinov, A Z; Barchukov, V G
2014-01-01
It was assessed the efficacy of drugs belonging to the class of actoprotectors and antihypoxants, which are prescribed for short-term adaptation of the human organism moving from middle altitude (1670 m) to high altitude (3750 m). Volunteers stayed at the middle altitude for 15 days before moving to the high altitude. Prior to climbing, upon arrival at high altitude, and on the 3rd day, the state of the CNS, cardiovascular system, red and white blood growth, and some indices of the energy exchange metabolism were assessed. Drugs or placebo were administered in tablets after the first testing (one hour before moving to high altitude), upon arrival at altitude (next day, after breakfast), and on the third day (one hour before last testing). It is established that a combination of metaprote and ladasten (in doses of 0.125 and 0.1 g, respectively) favors acceleration of the short-term adaptation, which is manifested by the improved tolerance of physical activity at high altitude and the acceleration of white and red blood growth. In case of the combined administration of both actoprotectors, the adaptive reactions of tolerance and blood system were more pronounced in comparison to the administration of hypoxen (0.5 g) alone. A distinguishing feature of the reaction of the human organism upon taking the combination of actoprotectors was that adaptation of the energy supply system (judging from metabolites studied) already took place in the first hours of staying at high altitudes, while the adaptation upon taking 0.5 g hypoxen was observed on the 3rd day and the adaptive reactions in placebo group were still developing on the 3rd day. PMID:25365868
NASA Astrophysics Data System (ADS)
Bena, Iosif; Heurtier, Lucien; Puhm, Andrea
2016-05-01
It was argued in [1] that the five-dimensional near-horizon extremal Kerr (NHEK) geometry can be embedded in String Theory as the infrared region of an infinite family of non-supersymmetric geometries that have D1, D5, momentum and KK monopole charges. We show that there exists a method to embed these geometries into asymptotically- {AdS}_3× {S}^3/{{Z}}_N solutions, and hence to obtain infinite families of flows whose infrared is NHEK. This indicates that the CFT dual to the NHEK geometry is the IR fixed point of a Renormalization Group flow from a known local UV CFT and opens the door to its explicit construction.
Classical string solutions in AdS{sub 5}xS{sup 5}
Murchikova, E. M.
2011-02-15
We discuss some new simple closed bosonic string solutions in AdS{sub 5}xS{sup 5} that may be of interest in the context of AdS/CFT duality. In the first part of this work we consider solutions with two spins (S{sub 1},S{sub 2}) in AdS{sub 5}. Starting from the flat-space solutions and using perturbation theory in the curvature of AdS{sub 5} space, we construct leading terms in the small two-spin solution. We find corrections to the leading Regge term in the classical string energy and uncover a discontinuity in the spectrum for a certain type of solution. We then analyze the connection between small-spin and large-spin limits of string solutions in AdS{sub 5}. We show that the S{sub 1}=S{sub 2} solution in AdS{sub 5} found in earlier papers admits both limits only in the simplest cases of the folded and rigid circular strings. In the second part of the paper, we construct a new class of chiral solutions in R{sub t}xS{sup 5} for which embedding coordinates of S{sup 5} satisfy the linear Laplace equations. They generalize the previously studied rigid string solutions. We study in detail a simple nontrivial example.
Shadows, currents, and AdS fields
Metsaev, R. R.
2008-11-15
Conformal totally symmetric arbitrary spin currents and shadow fields in flat space-time of dimension greater than or equal to four are studied. A gauge invariant formulation for such currents and shadow fields is developed. Gauge symmetries are realized by involving the Stueckelberg fields. A realization of global conformal boost symmetries is obtained. Gauge invariant differential constraints for currents and shadow fields are obtained. AdS/CFT correspondence for currents and shadow fields and the respective normalizable and non-normalizable solutions of massless totally symmetric arbitrary spin AdS fields are studied. The bulk fields are considered in a modified de Donder gauge that leads to decoupled equations of motion. We demonstrate that leftover on shell gauge symmetries of bulk fields correspond to gauge symmetries of boundary currents and shadow fields, while the modified de Donder gauge conditions for bulk fields correspond to differential constraints for boundary conformal currents and shadow fields. Breaking conformal symmetries, we find interrelations between the gauge invariant formulation of the currents and shadow fields, and the gauge invariant formulation of massive fields.
Gravitational correction to vacuum polarization
NASA Astrophysics Data System (ADS)
Jentschura, U. D.
2015-02-01
We consider the gravitational correction to (electronic) vacuum polarization in the presence of a gravitational background field. The Dirac propagators for the virtual fermions are modified to include the leading gravitational correction (potential term) which corresponds to a coordinate-dependent fermion mass. The mass term is assumed to be uniform over a length scale commensurate with the virtual electron-positron pair. The on-mass shell renormalization condition ensures that the gravitational correction vanishes on the mass shell of the photon, i.e., the speed of light is unaffected by the quantum field theoretical loop correction, in full agreement with the equivalence principle. Nontrivial corrections are obtained for off-shell, virtual photons. We compare our findings to other works on generalized Lorentz transformations and combined quantum-electrodynamic gravitational corrections to the speed of light which have recently appeared in the literature.
di Sarra, Alcide; Sferlazzo, Damiano; Meloni, Daniela; Anello, Fabrizio; Bommarito, Carlo; Corradini, Stefano; De Silvestri, Lorenzo; Di Iorio, Tatiana; Monteleone, Francesco; Pace, Giandomenico; Piacentino, Salvatore; Pugnaghi, Sergio
2015-04-01
Aerosol optical properties have been measured on the island of Lampedusa (35.5°N, 12.6°E) with seven-band multifilter rotating shadowband radiometers (MFRSRs) and a CE 318 Cimel sunphotometer (part of the AERONET network) since 1999. Four different MFRSRs have operated since 1999. The Cimel sunphotometer has been operational for a short period in 2000 and in 2003-2006 and 2010-present. Simultaneous determinations of the aerosol optical depth (AOD) from the two instruments were compared over a period of almost 4 years at several wavelengths between 415 and 870 nm. This is the first long-term comparison at a site strongly influenced by desert dust and marine aerosols and characterized by frequent cases of elevated AOD. The datasets show a good agreement, with MFRSR underestimating the Cimel AOD in cases with low Ångström exponent; the underestimate decreases for increasing wavelength and increases with AOD. This underestimate is attributed to the effect of aerosol forward scattering on the relatively wide field of view of the MFRSR. An empirical correction of the MFRSR data was implemented. After correction, the mean bias (MB) between MFRSR and Cimel simultaneous AOD determinations is always smaller than 0.004, and the root mean square difference is ≤0.031 at all wavelengths. The MB between MFRSR and Cimel monthly averages (for months with at least 20 days with AOD determinations) is 0.0052. Thus, by combining the MFRSR and Cimel observations, an integrated long-term series is obtained, covering the period 1999-present, with almost continuous measurements since early 2002. The long-term data show a small (nonstatistically significant) decreasing trend over the period 2002-2013, in agreement with independent observations in the Mediterranean. The integrated Lampedusa dataset will be used for aerosol climatological studies and for verification of satellite observations and model analyses. PMID:25967183
Positron annihilation lifetime spectroscopy source correction determination: A simulation study
NASA Astrophysics Data System (ADS)
Kanda, Gurmeet S.; Keeble, David J.
2016-02-01
Positron annihilation lifetime spectroscopy (PALS) can provide sensitive detection and identification of vacancy-related point defects in materials. These measurements are normally performed using a positron source supported, and enclosed by, a thin foil. Annihilation events from this source arrangement must be quantified and are normally subtracted from the spectrum before analysis of the material lifetime components proceeds. Here simulated PALS spectra reproducing source correction evaluation experiments have been systematically fitted and analysed using the packages PALSfit and MELT. Simulations were performed assuming a single lifetime material, and for a material with two lifetime components. Source correction terms representing a directly deposited source and various foil supported sources were added. It is shown that in principle these source terms can be extracted from suitably designed experiments, but that fitting a number of independent, nominally identical, spectra is recommended.
Barometric and Earth Tide Correction
Energy Science and Technology Software Center (ESTSC)
2005-11-10
BETCO corrects for barometric and earth tide effects in long-term water level records. A regression deconvolution method is used ot solve a series of linear equations to determine an impulse response function for the well pressure head. Using the response function, a pressure head correction is calculated and applied.
Aspects of warped AdS3/CFT2 correspondence
NASA Astrophysics Data System (ADS)
Chen, Bin; Zhang, Jia-Ju; Zhang, Jian-Dong; Zhong, De-Liang
2013-04-01
In this paper we apply the thermodynamics method to investigate the holographic pictures for the BTZ black hole, the spacelike and the null warped black holes in three-dimensional topologically massive gravity (TMG) and new massive gravity (NMG). Even though there are higher derivative terms in these theories, the thermodynamics method is still effective. It gives consistent results with the ones obtained by using asymptotical symmetry group (ASG) analysis. In doing the ASG analysis we develop a brute-force realization of the Barnich-Brandt-Compere formalism with Mathematica code, which also allows us to calculate the masses and the angular momenta of the black holes. In particular, we propose the warped AdS3/CFT2 correspondence in the new massive gravity, which states that quantum gravity in the warped spacetime could holographically dual to a two-dimensional CFT with {c_R}={c_L}=24 /{Gm{β^2√{{2( {21-4{β^2}} )}}}}.
An investigation of AdS2 backreaction and holography
NASA Astrophysics Data System (ADS)
Engelsöy, Julius; Mertens, Thomas G.; Verlinde, Herman
2016-07-01
We investigate a dilaton gravity model in AdS2 proposed by Almheiri and Polchinski [1] and develop a 1d effective description in terms of a dynamical boundary time with a Schwarzian derivative action. We show that the effective model is equivalent to a 1d version of Liouville theory, and investigate its dynamics and symmetries via a standard canonical framework. We include the coupling to arbitrary conformal matter and analyze the effective action in the presence of possible sources. We compute commutators of local operators at large time separation, and match the result with the time shift due to a gravitational shockwave interaction. We study a black hole evaporation process and comment on the role of entropy in this model.
On deformations of AdS n × S n supercosets
NASA Astrophysics Data System (ADS)
Hoare, B.; Roiban, R.; Tseytlin, A. A.
2014-06-01
We study the deformed AdS 5 × S 5 supercoset model of arXiv:1309.5850 which depends on one parameter κ and has classical quantum group symmetry. We confirm the conjecture that in the "maximal" deformation limit, κ → ∞, this model is T-dual to "flipped" double Wick rotation of the target space AdS 5 × S 5, i.e. dS 5 × H 5 space supported by an imaginary 5-form flux. In the imaginary deformation limit, κ → i, the corresponding target space metric is of a pp-wave type and thus the resulting light-cone gauge S-matrix becomes relativistically invariant. Omitting non-unitary contributions of imaginary WZ terms, we find that this tree-level S-matrix is equivalent to that of the generalized sine-Gordon model representing the Pohlmeyer reduction of the undeformed AdS 5 × S 5 superstring model. We also study in some detail similar deformations of the AdS 3 × S 3 and AdS 2 × S 2 supercosets. The bosonic part of the deformed AdS 3 × S 3 model happens to be equivalent to the symmetric case of the sum of the Fateev integrable deformation of the SL(2) and SU(2) principal chiral models, while in the AdS 2 × S 2 case the role of the Fateev model is played by the 2d "sausage" model. The κ = i limits are again directly related to the Pohlmeyer reductions of the corresponding AdS n × S n supercosets: (2,2) super sine-Gordon model and its complex sine-Gordon analog. We also discuss possible deformations of AdS 3 × S 3 with more than one parameter.
NASA Astrophysics Data System (ADS)
Stepanchuk, A.
2015-05-01
We present a semiclassical derivation of the tree-level and 1-loop dressing phases in the massive sector of string theory on Ad{{S}3}× {{S}3}× {{T}4} supplemented by Ramond-Ramond and Neveu-Schwarz-Neveu-Schwarz 3-form fluxes. In analogy with the Ad{{S}5}× {{S}5} case, we use the dressing method to obtain scattering solutions for dyonic giant magnons which allows us to determine the semiclassical bound-state S-matrix and its 1-loop correction. We also find that the 1-loop correction to the dyonic giant magnon energy vanishes. Looking at the relation between the bound-state picture and elementary magnons in terms of the fusion procedure we deduce the elementary dressing phases. In both the semiclassical and 1-loop cases we find agreement with recent proposals from finite-gap equations and unitarity cut methods. Further, we find consistency with the finite-gap picture by determining the resolvent for the dyonic giant magnon from the semiclassical bosonic scattering data.
CFT adapted gauge invariant formulation of massive arbitrary spin fields in AdS
NASA Astrophysics Data System (ADS)
Metsaev, R. R.
2010-01-01
Using Poincaré parametrization of AdS space, we study massive totally symmetric arbitrary spin fields in AdS space of dimension greater than or equal to four. CFT adapted gauge invariant formulation for such fields is developed. Gauge symmetries are realized by using Stueckelberg formulation of massive fields. We demonstrate that the mass parameter, curvature and radial coordinate contributions to the gauge transformation and Lagrangian of the AdS massive fields can be expressed in terms of ladder operators. Three representations for the Lagrangian are discussed. Realization of the global AdS symmetries in the conformal algebra basis is obtained. Modified de Donder gauge leading to simple gauge fixed Lagrangian is found. The modified de Donder gauge leads to decoupled equations of motion which can easily be solved in terms of the Bessel function. New simple representation for gauge invariant Lagrangian of massive (A)dS field in arbitrary coordinates is obtained. Light-cone gauge Lagrangian of massive AdS field is also presented.
From the generalized uncertainty relations on fuzzy AdS 2 to the Poincaré geometry
NASA Astrophysics Data System (ADS)
Fakhri, H.; Hashemi, A.; Lotfizadeh, M.
2012-03-01
The positive and discrete unitary irreps of SU(1,1) are used to construct fuzzy (Euclidean) AdS 2. Two different types of uncertainty relation involving the Weyl-Heisenberg and a weaker type are studied. It is shown that there are no generalized coherent states which simultaneously minimize the Weyl-Heisenberg uncertainty relations among three non-commuting embedding coordinates of the fuzzy AdS 2. However, generalized squeezed states that simultaneously satisfy the three weaker uncertainty relations do exist, and reproduce some properties of the classical AdS 2. Up to a common scaling factor in terms of the irrep label, the expectation values of the non-commuting coordinates over such states are described in the same manner as the classical AdS 2, in terms of the Poincaré coordinates. The expectation values on the fuzzy AdS 2 tend to their corresponding values in the commutative limit.
CFT adapted gauge invariant formulation of arbitrary spin fields in AdS and modified de Donder gauge
NASA Astrophysics Data System (ADS)
Metsaev, R. R.
2009-01-01
Using Poincaré parametrization of AdS space, we study totally symmetric arbitrary spin massless fields in AdS space of dimension greater than or equal to four. CFT adapted gauge invariant formulation for such fields is developed. Gauge symmetries are realized similarly to the ones of Stueckelberg formulation of massive fields. We demonstrate that the curvature and radial coordinate contributions to the gauge transformation and Lagrangian of the AdS fields can be expressed in terms of ladder operators. Realization of the global AdS symmetries in the conformal algebra basis is obtained. Modified de Donder gauge leading to simple gauge fixed Lagrangian is found. The modified de Donder gauge leads to decoupled equations of motion which can easily be solved in terms of the Bessel function. Interrelations between our approach to the massless AdS fields and the Stueckelberg approach to massive fields in flat space are discussed.
Magnetic mass in 4D AdS gravity
NASA Astrophysics Data System (ADS)
Araneda, René; Aros, Rodrigo; Miskovic, Olivera; Olea, Rodrigo
2016-04-01
We provide a fully covariant expression for the diffeomorphic charge in four-dimensional anti-de Sitter gravity, when the Gauss-Bonnet and Pontryagin terms are added to the action. The couplings of these topological invariants are such that the Weyl tensor and its dual appear in the on-shell variation of the action and such that the action is stationary for asymptotic (anti-)self-dual solutions in the Weyl tensor. In analogy with Euclidean electromagnetism, whenever the self-duality condition is global, both the action and the total charge are identically vanishing. Therefore, for such configurations, the magnetic mass equals the Ashtekhar-Magnon-Das definition.
NASA Technical Reports Server (NTRS)
Clauson, J.; Heuser, J.
1981-01-01
The Applications Data Service (ADS) is a system based on an electronic data communications network which will permit scientists to share the data stored in data bases at universities and at government and private installations. It is designed to allow users to readily locate and access high quality, timely data from multiple sources. The ADS Pilot program objectives and the current plans for accomplishing those objectives are described.
Shell corrections in stopping powers
NASA Astrophysics Data System (ADS)
Bichsel, H.
2002-05-01
One of the theories of the electronic stopping power S for fast light ions was derived by Bethe. The algorithm currently used for the calculation of S includes terms known as the mean excitation energy I, the shell correction, the Barkas correction, and the Bloch correction. These terms are described here. For the calculation of the shell corrections an atomic model is used, which is more realistic than the hydrogenic approximation used so far. A comparison is made with similar calculations in which the local plasma approximation is utilized. Close agreement with the experimental data for protons with energies from 0.3 to 10 MeV traversing Al and Si is found without the need for adjustable parameters for the shell corrections.
Johnson, D
1940-03-22
IN a recently published volume on "The Origin of Submarine Canyons" the writer inadvertently credited to A. C. Veatch an excerpt from a submarine chart actually contoured by P. A. Smith, of the U. S. Coast and Geodetic Survey. The chart in question is Chart IVB of Special Paper No. 7 of the Geological Society of America entitled "Atlantic Submarine Valleys of the United States and the Congo Submarine Valley, by A. C. Veatch and P. A. Smith," and the excerpt appears as Plate III of the volume fist cited above. In view of the heavy labor involved in contouring the charts accompanying the paper by Veatch and Smith and the beauty of the finished product, it would be unfair to Mr. Smith to permit the error to go uncorrected. Excerpts from two other charts are correctly ascribed to Dr. Veatch. PMID:17839404
Holographic Rényi entropy in AdS3/LCFT2 correspondence
NASA Astrophysics Data System (ADS)
Chen, Bin; Song, Feng-yan; Zhang, Jia-ju
2014-03-01
The recent study in AdS3/CFT2 correspondence shows that the tree level contribution and 1-loop correction of holographic Rényi entanglement entropy (HRE) exactly match the direct CFT computation in the large central charge limit. This allows the Rényi entanglement entropy to be a new window to study the AdS/CFT correspondence. In this paper we generalize the study of Rényi entanglement entropy in pure AdS3 gravity to the massive gravity theories at the critical points. For the cosmological topological massive gravity (CTMG), the dual conformal field theory (CFT) could be a chiral conformal field theory or a logarithmic conformal field theory (LCFT), depending on the asymptotic boundary conditions imposed. In both cases, by studying the short interval expansion of the Rényi entanglement entropy of two disjoint intervals with small cross ratio x, we find that the classical and 1-loop HRE are in exact match with the CFT results, up to order x 6. To this order, the difference between the massless graviton and logarithmic mode can be seen clearly. Moreover, for the cosmological new massive gravity (CNMG) at critical point, which could be dual to a logarithmic CFT as well, we find the similar agreement in the CNMG/LCFT correspondence. Furthermore we read the 2-loop correction of graviton and logarithmic mode to HRE from CFT computation. It has distinct feature from the one in pure AdS3 gravity.
Evidence for abrupt geomagnetic field intensity changes in Europe between 200 and 1400 AD
NASA Astrophysics Data System (ADS)
Gomez-Paccard, M.; Chauvin, A.; Lanos, P.
2013-05-01
Available archaeomagnetic data indicate that during the past 2500 yr there have been periods of rapid geomagnetic field intensity fluctuations interspersed with periods of almost constant field strength. Despite Europe being the most widely covered region in terms of archaeomagnetic data the occurrence and the behaviour of these rapid geomagnetic field intensity changes is under discussion and the challenge now is to precisely describe them. Here we present an improved description of the sharp intensity change that took place in Europe around 800 AD. For this purpose 13 precisely dated early medieval Spanish pottery fragments, four archaeological French kilns and three collections of bricks used for the construction of different French historical buildings with ages ranging between 335 and 1260 AD have been studied. Classical Thellier experiments performed on 164 specimens, and including anisotropy of thermoremanent magnetisation and cooling rate corrections, gave 119 reliable results. The 10 new high-quality mean archaeointensities obtained confirm the existence of an intensity maximum of about 85 μT (at the latitude of Paris) centred at ~800 AD and suggest that a previous abrupt intensity change occurred around 600 AD. Western European data also suggest the occurrence of abrupt geomagnetic field intensity changes during the 12th century AD and around the second half of the 13th century AD. Reliable selected eastern European data show a similar variation of geomagnetic field intensity with the occurrence of two intensity bumps (up to 75 μT at the latitude of Sofia) at ages around 650 and 950 AD and two periods of rapid intensity changes during the 12th century AD and 1300 AD. The results suggest that the described features of the geomagnetic field are observed at a continental scale and that very rapid intensity changes (of at least of 20 μT/century) took place in the recent history of the Earth's magnetic field.
AdOpt@TNG control system software
NASA Astrophysics Data System (ADS)
Baruffolo, Andrea; Ragazzoni, Roberto; Farinato, Jacopo
1998-09-01
AdOptTNG is the Adaptive Optics Module for the Galileo National telescope (TNG). At first light this module will feature tip-tilt correction capabilities and a speckle interferometry facility. In this paper we describe the main characteristics of the AdOptTNG Control System Software. The system is composed by a real-time part and a graphical user interface. The real-time software computes the required corrections, drives the tip-tilt mirror and function. The user interface has been written in IDL, using the IDL Widget set, taking advantage of its powerful data manipulation and analysis capabilities for data presentation and diagnostics. The integration of all these components into the TNG Control System Software, in order to allow for remote control and data archiving, is also briefly described.
Innovations Without Added Costs
ERIC Educational Resources Information Center
Cereghino, Edward
1974-01-01
There is no question that we are in a tight money market, and schools are among the first institutions to feel the squeeze. Therefore, when a plan is offered that provides for innovations without added costs, its something worth noting. (Editor)
ERIC Educational Resources Information Center
Richards, Andrew
2015-01-01
Two quantitative measures of school performance are currently used, the average points score (APS) at Key Stage 2 and value-added (VA), which measures the rate of academic improvement between Key Stage 1 and 2. These figures are used by parents and the Office for Standards in Education to make judgements and comparisons. However, simple…
Determining Positions and Desired Applicant Characteristics in Sports Job Ads
ERIC Educational Resources Information Center
Atali, Levent
2015-01-01
The purpose of this study is to determine the diversity of positions occurring in sports job ads and reveal the characteristics requested from applicants for each position. This study examined 103 sports-related job ads obtained from four human resources websites. Using content analysis, job ads were examined in terms of job titles, and the…
QCD Condensates and Holographic Wilson Loops for Asymptotically AdS Spaces
Quevedo, R. Carcasses; Goity, Jose L.; Trinchero, Roberto C.
2014-02-01
The minimization of the Nambu-Goto (NG) action for a surface whose contour defines a circular Wilson loop of radius a placed at a finite value of the coordinate orthogonal to the border is considered. This is done for asymptotically AdS spaces. The condensates of dimension n = 2, 4, 6, 8, and 10 are calculated in terms of the coefficients in the expansion in powers of the radius a of the on-shell subtracted NG action for small a->0. The subtraction employed is such that it presents no conflict with conformal invariance in the AdS case and need not introduce an additional infrared scale for the case of confining geometries. It is shown that the UV value of the gluon condensates is universal in the sense that it only depends on the first coefficients of the difference with the AdS case.
Solutions in bosonic string field theory and higher spin algebras in AdS
NASA Astrophysics Data System (ADS)
Polyakov, Dimitri
2015-11-01
We find a class of analytic solutions in open bosonic string field theory, parametrized by the chiral copy of higher spin algebra in AdS3. The solutions are expressed in terms of the generating function for the products of Bell polynomials in derivatives of bosonic space-time coordinates Xm(z ) of the open string, the form of which is determined in this work. The products of these polynomials form a natural operator algebra realizations of w∞ (area-preserving diffeomorphisms), enveloping algebra of SU(2) and higher spin algebra in AdS3. The class of string field theory solutions found can, in turn, be interpreted as the "enveloping of enveloping," or the enveloping of AdS3 higher spin algebra. We also discuss the extensions of this class of solutions to superstring theory and their relations to higher spin algebras in higher space-time dimensions.
Ali, Mir; Ruiz, Frenny; Saint-Victor, Carlos; Vazquez-Poritz, Justin F.
2009-08-15
We consider the behavior of open strings on anti-de Sitter wormholes in Gauss-Bonnet theory, which are the Gauss-Bonnet gravity duals of a pair of field theories. A string with both endpoints on the same side of the wormhole describes two charges within the same field theory, which exhibit Coulomb interaction for small separation. On the other hand, a string extending through the wormhole describes two charges which live in different field theories, and they exhibit a springlike confining potential. A transition occurs when there is a pair of charges present within each field theory: for small separation each pair of charges exhibits Coulomb interaction, while for large separation the charges in the different field theories pair up and exhibit confinement. Two steadily-moving charges in different field theories can occupy the same location provided that their speed is less than a critical speed, which also plays the role of a subluminal speed limit. However, for some wormhole backgrounds, charges moving at the critical speed cannot occupy the same location and energy is transferred from the leading charge to the lagging one. We also show that strings on anti-de Sitter wormholes in supergravity theories without higher-derivative curvature terms can exhibit these properties as well.
Localization in supergravity and quantum AdS 4 /CFT3 holography
NASA Astrophysics Data System (ADS)
Dabholkar, Atish; Drukker, Nadav; Gomes, João
2014-10-01
We compute the quantum gravity partition function of M-theory on AdS 4 × X 7 by using localization techniques in four-dimensional gauged supergravity obtained by a consistent truncation on the Sasaki-Einstein manifold X 7. The supergravity path integral reduces to a finite dimensional integral over two collective coordinates that parametrize the localizing instanton solutions. The renormalized action of the off-shell instanton solutions depends linearly and holomorphically on the "square root" prepotential evaluated at the center of AdS 4. The partition function resembles the Laplace transform of the wave function of a topological string and with an assumption about the measure for the localization integral yields an Airy function in precise agreement with the computation from the boundary ABJM theory on a 3-sphere. Our bulk quantum gravity computation is nonperturbatively exact in four-dimensional Planck length but ignores corrections due to brane-instantons.
Two Virasoro symmetries in stringy warped AdS3
NASA Astrophysics Data System (ADS)
Compère, Geoffrey; Guica, Monica; Rodriguez, Maria J.
2014-12-01
We study three-dimensional consistent truncations of type IIB supergravity which admit warped AdS3 solutions. These theories contain subsectors that have no bulk dynamics. We show that the symplectic form for these theories, when restricted to the non-dynamical subsectors, equals the symplectic form for pure Einstein gravity in AdS3. Consequently, for each consistent choice of boundary conditions in AdS3, we can define a consistent phase space in warped AdS3 with identical conserved charges. This way, we easily obtain a Virasoro × Virasoro asymptotic symmetry algebra in warped AdS3; two different types of Virasoro × Kač-Moody symmetries are also consistent alternatives.
Flux-limited diffusion with relativistic corrections
Pomraning, G.C.
1983-03-15
A recently reported flux-limited diffusion theory is extended to include relativistic terms, correct to first order in the fluid velocity. We show that this diffusion theory is fully flux limited, and yields the correct result for the radiative flux in the classical diffusion limit, namely a Fick's law component plus a v/c convective term.
Graviton corrections to Maxwell's equations
NASA Astrophysics Data System (ADS)
Leonard, Katie E.; Woodard, R. P.
2012-05-01
We use dimensional regularization to compute the one loop quantum gravitational contribution to the vacuum polarization on flat space background. Adding the appropriate Bogoliubov-Parsiuk-Hepp-Zimmermann counterterm gives a fully renormalized result which we employ to quantum correct Maxwell’s equations. These equations are solved to show that dynamical photons are unchanged, provided the free state wave functional is appropriately corrected. The response to the instantaneous appearance of a point dipole reveals a perturbative version of the long-conjectured, “smearing of the light cone”. There is no change in the far radiation field produced by an alternating dipole. However, the correction to the static electric field of a point charge shows strengthening at short distances, in contrast to expectations based on the renormalization group. We check for gauge dependence by working out the vacuum polarization in a general 3-parameter family of covariant gauges.
Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-14
... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY U. S. Customs and Border Protection 19 CFR Part 141 RIN 1515-AD61 (Formerly 1505-AB96) Technical Correction: Completion of Entry and Entry Summary-- Declaration of Value; Correction AGENCY: Customs...
Evans, Nick
2016-09-12
Essential facts Leading Change, Adding Value is NHS England's new nursing and midwifery framework. It is designed to build on Compassion in Practice (CiP), which was published 3 years ago and set out the 6Cs: compassion, care, commitment, courage, competence and communication. CiP established the values at the heart of nursing and midwifery, while the new framework sets out how staff can help transform the health and care sectors to meet the aims of the NHS England's Five Year Forward View. PMID:27615573
Cutting Budget Corners While Adding Value.
ERIC Educational Resources Information Center
Veile, Craig N.; Carpenter, Mark J.
2000-01-01
Discusses how one school district saved money while adding long- term value to its capital improvement project. Planning issues involving square footage requirements, quality of material to be used, and heating and cooling system selection are discussed as are concepts to increase student learning capacity for the same construction dollars. (GR)
NASA Astrophysics Data System (ADS)
Fakhri, Hossein; Imaanpur, Ali
2003-03-01
In this article we construct the chirality and Dirac operators on noncommutative AdS2. We also derive the discrete spectrum of the Dirac operator which is important in the study of the spectral triple associated to AdS2. It is shown that the degeneracy of the spectrum present in the commutative AdS2 is lifted in the noncommutative case. The way we construct the chirality operator is suggestive of how to introduce the projector operators of the corresponding projective modules on this space.
NASA Astrophysics Data System (ADS)
Molina-Vilaplana, Javier; Sierra, Germán
2013-12-01
In this paper we formulate the xp model on the AdS2 spacetime. We find that the spectrum of the Hamiltonian has positive and negative eigenvalues, whose absolute values are given by a harmonic oscillator spectrum, which in turn coincides with that of a massive Dirac fermion in AdS2. We extend this result to generic xp models which are shown to be equivalent to a massive Dirac fermion on spacetimes whose metric depend of the xp Hamiltonian. Finally, we construct the generators of the isometry group SO(2,1) of the AdS2 spacetime, and discuss the relation with conformal quantum mechanics.
AdS{sub 3} backgrounds from 10D effective action of heterotic string theory
Dominis Prester, Predrag
2010-02-15
We present a method for calculating solutions and corresponding central charges for backgrounds with AdS{sub 3} and S{sup k} factors in {alpha}{sup '}-exact fashion from the full tree-level low-energy effective action of heterotic string theory. Three examples are explicitly presented: AdS{sub 3}xS{sup 3}xT{sup 4}, AdS{sub 3}xS{sup 2}xS{sup 1}xT{sup 4}, and AdS{sub 3}xS{sup 3}xS{sup 3}xS{sup 1}. Crucial property which enabled our analysis is vanishing of the Riemann tensor calculated from connection with ''{sigma}-model torsion.'' We show the following: (i) Chern-Simons terms are the only source of {alpha}{sup '} corrections not only in BPS, but also in non-BPS cases, suggesting a possible extension of general method of Kraus and Larsen, (ii) our results are in agreement with some conjectures on the form of the part of tree-level Lagrangian not connected to a mixed Chern-Simons term by supersymmetry (and present in all supersymmetric string theories), (iii) new {alpha}{sup '}-exact result for central charges in AdS{sub 3}xS{sup 3}xS{sup 3}xS{sup 1} geometry. As a tool we used our generalization of Sen's E-function formalism to AdS{sub p} with p>2, and paid special attention to proper definition of asymptotic charges.
Gibson, Robert A; Anderson, Peter J; McPhee, Andrew J; Sullivan, Thomas R; Gould, Jacqueline F; Ryan, Philip; Doyle, Lex W; Davis, Peter G; McMichael, Judy E; French, Noel P; Colditz, Paul B; Simmer, Karen; Morris, Scott A; Makrides, Maria
2015-01-01
Objective To determine if improvements in cognitive outcome detected at 18 months’ corrected age (CA) in infants born <33 weeks’ gestation receiving a high-docosahexaenoic acid (DHA) compared with standard-DHA diet were sustained in early childhood. Design Follow-up of a multicentre randomised controlled trial. Randomisation was stratified for sex, birth weight (<1250 vs ≥1250 g) and hospital. Setting Five Australian tertiary hospitals from 2008 to 2013. Participants 626 of the 657 participants randomised between 2001 and 2005 were eligible to participate. Interventions High-DHA (≈1% total fatty acids) enteral feeds compared with standard-DHA (≈0.3% total fatty acids) from age 2–4 days until term CA. Primary outcome Full Scale IQ of the Wechsler Abbreviated Scale of Intelligence (WASI) at 7 years CA. Prespecified subgroup analyses based on the randomisation strata (sex, birth weight) were conducted. Results 604 (92% of the 657 originally randomised) consented to participate (291 high-DHA, 313 standard-DHA). To address missing data in the 604 consenting participants (22 for primary outcome), multiple imputation was performed. The Full Scale IQ was not significantly different between groups (high-DHA 98.3, SD 14.0, standard-DHA 98.5, SD 14.9; mean difference adjusted for sex, birthweight strata and hospital −0.3, 95% CI −2.9 to 2.2; p=0.79). There were no significant differences in any secondary outcomes. In prespecified subgroup analyses, there was a significant sex by treatment interaction on measures of parent-reported executive function and behaviour. Scores were within the normal range but girls receiving the high-DHA diet scored significantly higher (poorer outcome) compared with girls receiving the standard-DHA diet. Conclusions Supplementing the diets of preterm infants with a DHA dose of approximately 1% total fatty acids from days 2–4 until term CA showed no evidence of benefit at 7 years’ CA. Trial registration number
Bayesian redshift-space distortions correction from galaxy redshift surveys
NASA Astrophysics Data System (ADS)
Kitaura, Francisco-Shu; Ata, Metin; Angulo, Raul E.; Chuang, Chia-Hsun; Rodríguez-Torres, Sergio; Monteagudo, Carlos Hernández; Prada, Francisco; Yepes, Gustavo
2016-03-01
We present a Bayesian reconstruction method which maps a galaxy distribution from redshift- to real-space inferring the distances of the individual galaxies. The method is based on sampling density fields assuming a lognormal prior with a likelihood modelling non-linear stochastic bias. Coherent redshift-space distortions are corrected in a Gibbs-sampling procedure by moving the galaxies from redshift- to real-space according to the peculiar motions derived from the recovered density field using linear theory. The virialized distortions are corrected by sampling candidate real-space positions along the line of sight, which are compatible with the bulk flow corrected redshift-space position adding a random dispersion term in high-density collapsed regions (defined by the eigenvalues of the Hessian). This approach presents an alternative method to estimate the distances to galaxies using the three-dimensional spatial information, and assuming isotropy. Hence the number of applications is very broad. In this work, we show the potential of this method to constrain the growth rate up to k ˜ 0.3 h Mpc-1. Furthermore it could be useful to correct for photometric redshift errors, and to obtain improved baryon acoustic oscillations (BAO) reconstructions.
Massive quiver matrix models for massive charged particles in AdS
NASA Astrophysics Data System (ADS)
Asplund, Curtis T.; Denef, Frederik; Dzienkowski, Eric
2016-01-01
We present a new class of N=4 supersymmetric quiver matrix models and argue that it describes the stringy low-energy dynamics of internally wrapped D-branes in four-dimensional anti-de Sitter (AdS) flux compactifications. The Lagrangians of these models differ from previously studied quiver matrix models by the presence of mass terms, associated with the AdS gravitational potential, as well as additional terms dictated by supersymmetry. These give rise to dynamical phenomena typically associated with the presence of fluxes, such as fuzzy membranes, internal cyclotron motion and the appearance of confining strings. We also show how these models can be obtained by dimensional reduction of four-dimensional supersymmetric quiver gauge theories on a three-sphere.
Nearly Conformal QCD and AdS/CFT
de Teramond, Guy F.; Brodsky, Stanley J.; /Costa Rica U. /SLAC
2005-08-08
The AdS/CFT correspondence is a powerful tool to study the properties of conformal QCD at strong coupling in terms of a higher dimensional dual gravity theory. The power-law falloff of scattering amplitudes in the non-perturbative regime and calculable hadron spectra follow from holographic models dual to QCD with conformal behavior at short distances and confinement at large distances. String modes and fluctuations about the AdS background are identified with QCD degrees of freedom and orbital excitations at the AdS boundary limit. A description of form factors in space and time-like regions and the behavior of light-front wave functions can also be understood in terms of a dual gravity description in the interior of AdS.
NASA Astrophysics Data System (ADS)
Kikuchi, Kenji
2010-06-01
Accelerator driven nuclear transmutation system has been pursued to have a clue to the solution of high-level radioactive waste management. The concept consists of super conducting linac, sub-critical reactor and the beam window. Reference model is set up to 800MW thermal power by using 1.5GeV proton beams with considerations multi-factors such as core criticality. Materials damage is simulated by high-energy particle transport codes and so on. Recent achievement on irradiation materials experiment is stated and the differences are pointed out if core burn-up is considered or not. Heat balance in tank-type ADS indicates the temperature conditions of steam generator, the beam widow and cladding materials. Lead-bismuth eutectics demonstration has been conducted. Corrosion depth rate was shown by experiments.
Logarithmic corrections to the entanglement entropy
NASA Astrophysics Data System (ADS)
Park, Chanyong
2015-12-01
In a d -dimensional conformal field theory, it has been known that a relevant deformation operator with the conformal dimension, Δ =d/+2 2 , generates a logarithmic correction to the entanglement entropy. In the large 't Hooft coupling limit, we can investigate such a logarithmic correction holographically by deforming an AdS space with a massive scalar field dual to the operator with Δ =d/+2 2 . There are two sources generating the logarithmic correction. One is the metric deformation and the other is the minimal surface deformation. In this work, we investigate the change of the entanglement entropy caused by the minimal surface deformation and find that the second order minimal surface deformation leads to an additional logarithmic correction.
Holographic p-wave superconductor models with Weyl corrections
NASA Astrophysics Data System (ADS)
Zhang, Lu; Pan, Qiyuan; Jing, Jiliang
2015-04-01
We study the effect of the Weyl corrections on the holographic p-wave dual models in the backgrounds of AdS soliton and AdS black hole via a Maxwell complex vector field model by using the numerical and analytical methods. We find that, in the soliton background, the Weyl corrections do not influence the properties of the holographic p-wave insulator/superconductor phase transition, which is different from that of the Yang-Mills theory. However, in the black hole background, we observe that similarly to the Weyl correction effects in the Yang-Mills theory, the higher Weyl corrections make it easier for the p-wave metal/superconductor phase transition to be triggered, which shows that these two p-wave models with Weyl corrections share some similar features for the condensation of the vector operator.
The forecaster's added value in QPF
NASA Astrophysics Data System (ADS)
Turco, M.; Milelli, M.
2009-04-01
skill scores of two competitive forecast. It is important to underline that the conclusions refer to the analysis of the Piemonte operational alert system, so they cannot be directly taken as universally true. But we think that some of the main lessons that can be derived from this study could be useful for the meteorological community. In details, the main conclusions are the following: · despite the overall improvement in global scale and the fact that the resolution of the limited area models has increased considerably over recent years, the QPF produced by the meteorological models involved in this study has not improved enough to allow its direct use: the subjective HQPF continues to offer the best performance; · in the forecast process, the step where humans have the largest added value with respect to mathematical models, is the communication. In fact the human characterisation and communication of the forecast uncertainty to end users cannot be replaced by any computer code; · the QPFs verification is one of the most important activities of a Centro Funzionale because it allows a better understanding of the model behaviour in the different meteorological configurations, highlights the systematic characteristics, and helps in evaluating the reliability, in average or extreme values, over long term or in current situations; · eventually, although there is no novelty in this study, we would like to show that the correct application of appropriated statistical tecniques permits a better definition and quantification of the errors and, mostly important, allows a correct (unbiased) communication between forecasters and decision makers.
Value Added in English Schools
ERIC Educational Resources Information Center
Ray, Andrew; McCormack, Tanya; Evans, Helen
2009-01-01
Value-added indicators are now a central part of school accountability in England, and value-added information is routinely used in school improvement at both the national and the local levels. This article describes the value-added models that are being used in the academic year 2007-8 by schools, parents, school inspectors, and other…
Hartung, Thomas
2009-12-01
Taking the 110th anniversary of marketing of aspirin as starting point, the almost scary toxicological profile of aspirin is contrasted with its actual use experience. The author concludes that we are lucky that, in 1899, there was no regulatory toxicology. Adding, for the purpose of this article, a fourth R to the Three Rs, i.e. Realism, three reality-checks are carried out. The first one comes to the conclusion that the tools of toxicology are hardly adequate for the challenges ahead. The second one concludes that, specifically, the implementation of the EU REACH system is not feasible with these tools, mainly with regard to throughput. The third one challenges the belief that classical alternative methods, i.e. replacing animal test-based tools one by one, is actually leading to a new toxicology - it appears to change only patches of the patchwork, but not to overcome any inherent limitations other than ethical ones. The perspective lies in the Toxicology for the 21st Century initiatives, which aim to create a new approach from the scratch, by an evidence-based toxicology and a global "Human Toxicology Programme". PMID:20105011
Quantum compositeness of gravity: black holes, AdS and inflation
Dvali, Gia; Gomez, Cesar
2014-01-14
Gravitational backgrounds, such as black holes, AdS, de Sitter and inflationary universes, should be viewed as composite of N soft constituent gravitons. It then follows that such systems are close to quantum criticality of graviton Bose-gas to Bose-liquid transition. Generic properties of the ordinary metric description, including geodesic motion or particle-creation in the background metric, emerge as the large-N limit of quantum scattering of constituent longitudinal gravitons. We show that this picture correctly accounts for physics of large and small black holes in AdS, as well as reproduces well-known inflationary predictions for cosmological parameters. However, it anticipates new effects not captured by the standard semi-classical treatment. In particular, we predict observable corrections that are sensitive to the inflationary history way beyond last 60 e-foldings. We derive an absolute upper bound on the number of e-foldings, beyond which neither de Sitter nor inflationary Universe can be approximated by a semi-classical metric. However, they could in principle persist in a new type of quantum eternity state. We discuss implications of this phenomenon for the cosmological constant problem.
Quantum compositeness of gravity: black holes, AdS and inflation
Dvali, Gia; Gomez, Cesar E-mail: cesar.gomez@uam.es
2014-01-01
Gravitational backgrounds, such as black holes, AdS, de Sitter and inflationary universes, should be viewed as composite of N soft constituent gravitons. It then follows that such systems are close to quantum criticality of graviton Bose-gas to Bose-liquid transition. Generic properties of the ordinary metric description, including geodesic motion or particle-creation in the background metric, emerge as the large-N limit of quantum scattering of constituent longitudinal gravitons. We show that this picture correctly accounts for physics of large and small black holes in AdS, as well as reproduces well-known inflationary predictions for cosmological parameters. However, it anticipates new effects not captured by the standard semi-classical treatment. In particular, we predict observable corrections that are sensitive to the inflationary history way beyond last 60 e-foldings. We derive an absolute upper bound on the number of e-foldings, beyond which neither de Sitter nor inflationary Universe can be approximated by a semi-classical metric. However, they could in principle persist in a new type of quantum eternity state. We discuss implications of this phenomenon for the cosmological constant problem.
The AdS n × S n × T 10-2 n BMN string at two loops
NASA Astrophysics Data System (ADS)
Sundin, Per; Wulff, Linus
2015-11-01
We calculate the two-loop correction to the dispersion relation for worldsheet modes of the BMN string in AdS n × S n × T 10-2 n for n = 2 , 3 , 5. For the massive modes the result agrees with the exact dispersion relation derived from symmetry considerations with no correction to the interpolating function h. For the massless modes in AdS3 × S 3 × T 4 however our result does not match what one expects from the corresponding symmetry based analysis. We also derive the S-matrix for massless modes up to the one-loop order. The scattering phase is given by the massless limit of the Hernández-López phase. In addition we compute a certain massless S-matrix element at two loops and show that it vanishes suggesting that the two-loop phase in the massless sector is zero.
Supergravity at the boundary of AdS supergravity
NASA Astrophysics Data System (ADS)
Amsel, Aaron J.; Compère, Geoffrey
2009-04-01
We give a general analysis of AdS boundary conditions for spin-3/2 Rarita-Schwinger fields and investigate boundary conditions preserving supersymmetry for a graviton multiplet in AdS4. Linear Rarita-Schwinger fields in AdSd are shown to admit mixed Dirichlet-Neumann boundary conditions when their mass is in the range 0≤|m|<1/2lAdS. We also demonstrate that mixed boundary conditions are allowed for larger masses when the inner product is “renormalized” accordingly with the action. We then use the results obtained for |m|=1/lAdS to explore supersymmetric boundary conditions for N=1 AdS4 supergravity in which the metric and Rarita-Schwinger fields are fluctuating at the boundary. We classify boundary conditions that preserve boundary supersymmetry or superconformal symmetry. Under the AdS/CFT dictionary, Neumann boundary conditions in d=4 supergravity correspond to gauging the superconformal group of the three-dimensional CFT describing M2-branes, while N=1 supersymmetric mixed boundary conditions couple the CFT to N=1 superconformal topologically massive gravity.
"New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS).
Nelson, Peter T; Trojanowski, John Q; Abner, Erin L; Al-Janabi, Omar M; Jicha, Gregory A; Schmitt, Frederick A; Smith, Charles D; Fardo, David W; Wang, Wang-Xia; Kryscio, Richard J; Neltner, Janna H; Kukull, Walter A; Cykowski, Matthew D; Van Eldik, Linda J; Ighodaro, Eseosa T
2016-06-01
The pathology-based classification of Alzheimer's disease (AD) and other neurodegenerative diseases is a work in progress that is important for both clinicians and basic scientists. Analyses of large autopsy series, biomarker studies, and genomics analyses have provided important insights about AD and shed light on previously unrecognized conditions, enabling a deeper understanding of neurodegenerative diseases in general. After demonstrating the importance of correct disease classification for AD and primary age-related tauopathy, we emphasize the public health impact of an underappreciated AD "mimic," which has been termed "hippocampal sclerosis of aging" or "hippocampal sclerosis dementia." This pathology affects >20% of individuals older than 85 years and is strongly associated with cognitive impairment. In this review, we provide an overview of current hypotheses about how genetic risk factors (GRN, TMEM106B, ABCC9, and KCNMB2), and other pathogenetic influences contribute to TDP-43 pathology and hippocampal sclerosis. Because hippocampal sclerosis of aging affects the "oldest-old" with arteriolosclerosis and TDP-43 pathologies that extend well beyond the hippocampus, more appropriate terminology for this disease is required. We recommend "cerebral age-related TDP-43 and sclerosis" (CARTS). A detailed case report is presented, which includes neuroimaging and longitudinal neurocognitive data. Finally, we suggest a neuropathology-based diagnostic rubric for CARTS. PMID:27209644
NASA Technical Reports Server (NTRS)
Berard, Peter R.
1993-01-01
Researchers in the Molecular Sciences Research Center (MSRC) of Pacific Northwest Laboratory (PNL) currently generate massive amounts of scientific data. The amount of data that will need to be managed by the turn of the century is expected to increase significantly. Automated tools that support the management, maintenance, and sharing of this data are minimal. Researchers typically manage their own data by physically moving datasets to and from long term storage devices and recording a dataset's historical information in a laboratory notebook. Even though it is not the most efficient use of resources, researchers have tolerated the process. The solution to this problem will evolve over the next three years in three phases. PNL plans to add sophistication to existing multilevel file system (MLFS) software by integrating it with an object database management system (ODBMS). The first phase in the evolution is currently underway. A prototype system of limited scale is being used to gather information that will feed into the next two phases. This paper describes the prototype system, identifies the successes and problems/complications experienced to date, and outlines PNL's long term goals and objectives in providing a permanent solution.
... the basis for prescribing glasses and contact lenses. Vision Services Refractive and optical services delivered by ophthalmologists, ... an examination of the eye for corrective lenses. Vision Care A term commonly used to describe vision ...
Asymptotically AdS spacetimes with a timelike Kasner singularity
NASA Astrophysics Data System (ADS)
Ren, Jie
2016-07-01
Exact solutions to Einstein's equations for holographic models are presented and studied. The IR geometry has a timelike cousin of the Kasner singularity, which is the less generic case of the BKL (Belinski-Khalatnikov-Lifshitz) singularity, and the UV is asymptotically AdS. This solution describes a holographic RG flow between them. The solution's appearance is an interpolation between the planar AdS black hole and the AdS soliton. The causality constraint is always satisfied. The entanglement entropy and Wilson loops are discussed. The boundary condition for the current-current correlation function and the Laplacian in the IR is examined. There is no infalling wave in the IR, but instead, there is a normalizable solution in the IR. In a special case, a hyperscaling-violating geometry is obtained after a dimensional reduction.
All AdS7 solutions of type II supergravity
NASA Astrophysics Data System (ADS)
Apruzzi, Fabio; Fazzi, Marco; Rosa, Dario; Tomasiello, Alessandro
2014-04-01
In M-theory, the only AdS7 supersymmetric solutions are AdS7 × S 4 and its orbifolds. In this paper, we find and classify new supersymmetric solutions of the type AdS7 × M 3 in type II supergravity. While in IIB none exist, in IIA with Romans mass (which does not lift to M-theory) there are many new ones. We use a pure spinor approach reminiscent of generalized complex geometry. Without the need for any Ansatz, the system determines uniquely the form of the metric and fluxes, up to solving a system of ODEs. Namely, the metric on M 3 is that of an S 2 fibered over an interval; this is consistent with the Sp(1) R-symmetry of the holographically dual (1,0) theory. By including D8 brane sources, one can numerically obtain regular solutions, where topologically M 3 ≅ S 3.
Detailed ultraviolet asymptotics for AdS scalar field perturbations
NASA Astrophysics Data System (ADS)
Evnin, Oleg; Jai-akson, Puttarak
2016-04-01
We present a range of methods suitable for accurate evaluation of the leading asymptotics for integrals of products of Jacobi polynomials in limits when the degrees of some or all polynomials inside the integral become large. The structures in question have recently emerged in the context of effective descriptions of small amplitude perturbations in anti-de Sitter (AdS) spacetime. The limit of high degree polynomials corresponds in this situation to effective interactions involving extreme short-wavelength modes, whose dynamics is crucial for the turbulent instabilities that determine the ultimate fate of small AdS perturbations. We explicitly apply the relevant asymptotic techniques to the case of a self-interacting probe scalar field in AdS and extract a detailed form of the leading large degree behavior, including closed form analytic expressions for the numerical coefficients appearing in the asymptotics.
Self-correcting Multigrid Solver
Jerome L.V. Lewandowski
2004-06-29
A new multigrid algorithm based on the method of self-correction for the solution of elliptic problems is described. The method exploits information contained in the residual to dynamically modify the source term (right-hand side) of the elliptic problem. It is shown that the self-correcting solver is more efficient at damping the short wavelength modes of the algebraic error than its standard equivalent. When used in conjunction with a multigrid method, the resulting solver displays an improved convergence rate with no additional computational work.
Sonde Adjust Value-Added Product Technical Report
Troyan, D
2012-01-09
The Sonde Adjust (SONDEADJUST) value-added product (VAP) creates a file that includes all fields from original Atmospheric Radiation Measurement Climate Research Facility (ARM Facility) radiosonde files and contains several value-added fields that provide adjustments related to well-known humidity issues. SONDEADJUST produces data that correct documented biases in radiosonde humidity measurements. Previous efforts towards applying some of these corrections are available via the discontinued PI product sgpsondecorr1miloC1. Unique fields contained within this datastream include smoothed original relative humidity, dry bias corrected relative humidity, and final corrected relative humidity. The smoothed RH field refines the relative humidity from integers-the resolution of the instrument-to fractions of a percent. This profile is then used to calculate the dry bias corrected field. The final correction fixes the time-lag problem and uses the dry-bias field as input into the algorithm. In addition to dry bias, solar heating is another correction that is encompassed in the final corrected RH field. Output from SONDEADJUST differs from the previous RH-corrected datastreams in important ways. First, all three types of ARM radiosondes-Vaisala RS-80, RS-90, and RS-92-are corrected using dedicated procedures and/or parameters. Second, the output variables include all of those found in the original radiosonde file: dry bulb temperature, dewpoint temperature, wind speed, wind direction, eastward wind component, northward wind component, wind status (a Vaisala-produced field used in conjunction with the Loran system), ascent rate, and original relative humidity. Additional humidity fields are smoothed relative humidity, dry biased corrected relative humidity, final ambient relative humidity, and scaled adjusted relative humidity. Third, quality control (QC) flags of the fields from the original radiosonde datastream are brought into the SONDEADJUST output file. Additional QC
Noncommutative extension of AdS-CFT and holographic superconductors
NASA Astrophysics Data System (ADS)
Pramanik, Souvik; Das, Sudipta; Ghosh, Subir
2015-03-01
In this Letter, we consider a Non-Commutative (NC) extension of AdS-CFT correspondence and its effects on holographic superconductors. NC corrections are incorporated via the NC generalization of Schwarzschild black hole metric in AdS with the probe limit. We study NC effects on the relations connecting the charge density and the critical temperature of the Holographic Superconductors. Furthermore, condensation operator of the superconductor has been analyzed. Our results suggest that generically, NC effects increase the critical temperature of the holographic superconductor.
77 FR 72199 - Technical Corrections; Correction
Federal Register 2010, 2011, 2012, 2013, 2014
2012-12-05
...) is correcting a final rule that was published in the Federal Register on July 6, 2012 (77 FR 39899... . SUPPLEMENTARY INFORMATION: On July 6, 2012 (77 FR 39899), the NRC published a final rule in the Federal Register... typographical and spelling errors, and making other edits and conforming changes. This correcting amendment...
Rx for Pedagogical Correctness: Professional Correctness.
ERIC Educational Resources Information Center
Lasley, Thomas J.
1993-01-01
Describes the difficulties caused by educators holding to a view of teaching that assumes that there is one "pedagogically correct" way of running a classroom. Provides three examples of harmful pedagogical correctness ("untracked" classes, cooperative learning, and testing and test-wiseness). Argues that such dogmatic views of education limit…
Phases of global AdS black holes
NASA Astrophysics Data System (ADS)
Basu, Pallab; Krishnan, Chethan; Subramanian, P. N. Bala
2016-06-01
We study the phases of gravity coupled to a charged scalar and gauge field in an asymptotically Anti-de Sitter spacetime ( AdS 4) in the grand canonical ensemble. For the conformally coupled scalar, an intricate phase diagram is charted out between the four relevant solutions: global AdS, boson star, Reissner-Nordstrom black hole and the hairy black hole. The nature of the phase diagram undergoes qualitative changes as the charge of the scalar is changed, which we discuss. We also discuss the new features that arise in the extremal limit.
Conformal mass in Einstein-Gauss-Bonnet AdS gravity
NASA Astrophysics Data System (ADS)
Jatkar, Dileep P.; Kofinas, Georgios; Miskovic, Olivera; Olea, Rodrigo
2015-05-01
In this paper, we show that the physical information given by conserved charges for asymptotically AdS spacetimes in Einstein-Gauss-Bonnet AdS gravity is encoded in the electric part of the Weyl tensor. This result generalizes the conformal mass definition by Ashtekar-Magnon-Das (AMD) to a gravity theory with a Gauss-Bonnet term. This proof makes use of the Noether charges obtained from an action renormalized by the addition of counterterms which depend on the extrinsic curvature (Kounterterms). If the asymptotic fall-off behavior of the Weyl tensor is same as the one considered in the AMD method, then the Kounterterm charges and the AMD charges agree in any dimension.
Symmetry operators of Killing spinors and superalgebras in AdS5
NASA Astrophysics Data System (ADS)
Ertem, Ümit
2016-04-01
We construct the first-order symmetry operators of Killing spinor equation in terms of odd Killing-Yano forms. By modifying the Schouten-Nijenhuis bracket of Killing-Yano forms, we show that the symmetry operators of Killing spinors close into an algebra in AdS5 spacetime. Since the symmetry operator algebra of Killing spinors corresponds to a Jacobi identity in extended Killing superalgebras, we investigate the possible extensions of Killing superalgebras to include higher-degree Killing-Yano forms. We found that there is a superalgebra extension but no Lie superalgebra extension of the Killing superalgebra constructed out of Killing spinors and odd Killing-Yano forms in AdS5 background.
Euclidean Wilson loops and minimal area surfaces in lorentzian AdS 3
NASA Astrophysics Data System (ADS)
Irrgang, Andrew; Kruczenski, Martin
2015-12-01
The AdS/CFT correspondence relates Wilson loops in N=4 SYM theory to minimal area surfaces in AdS 5 × S 5 space. If the Wilson loop is Euclidean and confined to a plane ( t, x) then the dual surface is Euclidean and lives in Lorentzian AdS 3 ⊂ AdS 5. In this paper we study such minimal area surfaces generalizing previous results obtained in the Euclidean case. Since the surfaces we consider have the topology of a disk, the holonomy of the flat current vanishes which is equivalent to the condition that a certain boundary Schrödinger equation has all its solutions anti-periodic. If the potential for that Schrödinger equation is found then reconstructing the surface and finding the area become simpler. In particular we write a formula for the Area in terms of the Schwarzian derivative of the contour. Finally an infinite parameter family of analytical solutions using Riemann Theta functions is described. In this case, both the area and the shape of the surface are given analytically and used to check the previous results.
Dispersion- and Exchange-Corrected Density Functional Theory for Sodium Ion Hydration.
Soniat, Marielle; Rogers, David M; Rempe, Susan B
2015-07-14
A challenge in density functional theory is developing functionals that simultaneously describe intermolecular electron correlation and electron delocalization. Recent exchange-correlation functionals address those two issues by adding corrections important at long ranges: an atom-centered pairwise dispersion term to account for correlation and a modified long-range component of the electron exchange term to correct for delocalization. Here we investigate how those corrections influence the accuracy of binding free energy predictions for sodium-water clusters. We find that the dual-corrected ωB97X-D functional gives cluster binding energies closest to high-level ab initio methods (CCSD(T)). Binding energy decomposition shows that the ωB97X-D functional predicts the smallest ion-water (pairwise) interaction energy and larger multibody contributions for a four-water cluster than most other functionals - a trend consistent with CCSD(T) results. Also, ωB97X-D produces the smallest amounts of charge transfer and the least polarizable waters of the density functionals studied, which mimics the lower polarizability of CCSD. When compared with experimental binding free energies, however, the exchange-corrected CAM-B3LYP functional performs best (error <1 kcal/mol), possibly because of its parametrization to experimental formation enthalpies. For clusters containing more than four waters, "split-shell" coordination must be considered to obtain accurate free energies in comparison with experiment. PMID:26575733
Error Correction as a Cultural Phenomenon
ERIC Educational Resources Information Center
McGarry, Richard
2004-01-01
This study examines the pedagogical and pragmatic motives behind error correction both in classroom contexts and in everyday conversation among native Spanish-speaking English teachers in Costa Rica. Survey and interview data are analyzed and discussed in terms of participants' attitudes toward correction of errors in L1 and L2 in various…
The forecaster's added value in QPF
NASA Astrophysics Data System (ADS)
Turco, M.; Milelli, M.
2010-03-01
: - despite the overall improvement in global scale and the fact that the resolution of the limited area models has increased considerably over recent years, the QPF produced by the meteorological models involved in this study has not improved enough to allow its direct use: the subjective HQPF continues to offer the best performance for the period +24 h/+48 h (i.e. the warning period in the Piemonte system); - in the forecast process, the step where humans have the largest added value with respect to mathematical models, is the communication. In fact the human characterization and communication of the forecast uncertainty to end users cannot be replaced by any computer code; - eventually, although there is no novelty in this study, we would like to show that the correct application of appropriated statistical techniques permits a better definition and quantification of the errors and, mostly important, allows a correct (unbiased) communication between forecasters and decision makers.
EDITORIAL: Politically correct physics?
NASA Astrophysics Data System (ADS)
Pople Deputy Editor, Stephen
1997-03-01
If you were a caring, thinking, liberally minded person in the 1960s, you marched against the bomb, against the Vietnam war, and for civil rights. By the 1980s, your voice was raised about the destruction of the rainforests and the threat to our whole planetary environment. At the same time, you opposed discrimination against any group because of race, sex or sexual orientation. You reasoned that people who spoke or acted in a discriminatory manner should be discriminated against. In other words, you became politically correct. Despite its oft-quoted excesses, the political correctness movement sprang from well-founded concerns about injustices in our society. So, on balance, I am all for it. Or, at least, I was until it started to invade science. Biologists were the first to feel the impact. No longer could they refer to 'higher' and 'lower' orders, or 'primitive' forms of life. To the list of undesirable 'isms' - sexism, racism, ageism - had been added a new one: speciesism. Chemists remained immune to the PC invasion, but what else could you expect from a group of people so steeped in tradition that their principal unit, the mole, requires the use of the thoroughly unreconstructed gram? Now it is the turn of the physicists. This time, the offenders are not those who talk disparagingly about other people or animals, but those who refer to 'forms of energy' and 'heat'. Political correctness has evolved into physical correctness. I was always rather fond of the various forms of energy: potential, kinetic, chemical, electrical, sound and so on. My students might merge heat and internal energy into a single, fuzzy concept loosely associated with moving molecules. They might be a little confused at a whole new crop of energies - hydroelectric, solar, wind, geothermal and tidal - but they could tell me what devices turned chemical energy into electrical energy, even if they couldn't quite appreciate that turning tidal energy into geothermal energy wasn't part of the
NASA Technical Reports Server (NTRS)
Stothers, R. B.
1984-01-01
The possible cause of the densest and most persistent dry fog on record, which was observed in Europe and the Middle East during AD 536 and 537, is discussed. The fog's long duration toward the south and the high sulfuric acid signal detected in Greenland in ice cores dated around AD 540 support the theory that the fog was due to the explosion of the Rabaul volcano, the occurrence of which has been dated at about AD 540 by the radiocarbon method.
AdS Branes from Partial Breaking of Superconformal Symmetries
Ivanov, E.A.
2005-10-01
It is shown how the static-gauge world-volume superfield actions of diverse superbranes on the AdS{sub d+1} superbackgrounds can be systematically derived from nonlinear realizations of the appropriate AdS supersymmetries. The latter are treated as superconformal symmetries of flat Minkowski superspaces of the bosonic dimension d. Examples include the N = 1 AdS{sub 4} supermembrane, which is associated with the 1/2 partial breaking of the OSp(1|4) supersymmetry down to the N = 1, d = 3 Poincare supersymmetry, and the T-duality related L3-brane on AdS{sub 5} and scalar 3-brane on AdS{sub 5} x S{sup 1}, which are associated with two different patterns of 1/2 breaking of the SU(2, 2|1) supersymmetry. Another (closely related) topic is the AdS/CFT equivalence transformation. It maps the world-volume actions of the codimension-one AdS{sub d+1} (super)branes onto the actions of the appropriate Minkowski (super)conformal field theories in the dimension d.
Raman Lidar Profiles–Temperature (RLPROFTEMP) Value-Added Product
Newsom, RK; Sivaraman, C; McFarlane, SA
2012-10-31
The purpose of this document is to describe the Raman Lidar Profiles–Temperature (RLPROFTEMP) value-added product (VAP) and the procedures used to derive atmospheric temperature profiles from the raw RL measurements. Sections 2 and 4 describe the input and output variables, respectively. Section 3 discusses the theory behind the measurement and the details of the algorithm, including calibration and overlap correction.
Providing Location Security in Vehicular Ad Hoc Networks
ERIC Educational Resources Information Center
Yan, Gongjun
2010-01-01
Location is fundamental information in Vehicular Ad-hoc Networks (VANETs). Almost all VANET applications rely on location information. Therefore it is of importance to ensure location information integrity, meaning that location information is original (from the generator), correct (not bogus or fabricated) and unmodified (value not changed). We…
AdS5 backgrounds with 24 supersymmetries
NASA Astrophysics Data System (ADS)
Beck, S.; Gutowski, J.; Papadopoulos, G.
2016-06-01
We prove a non-existence theorem for smooth AdS 5 solutions with connected, compact without boundary internal space that preserve strictly 24 supersymmetries. In particular, we show that D = 11 supergravity does not admit such solutions, and that all such solutions of IIB supergravity are locally isometric to the AdS 5 × S 5 maximally supersymmetric background. Furthermore, we prove that (massive) IIA supergravity also does not admit such solutions, provided that the homogeneity conjecture for massive IIA supergravity is valid. In the context of AdS/CFT these results imply that if gravitational duals for strictly mathcal{N}=3 superconformal theories in 4-dimensions exist, they are either singular or their internal spaces are not compact.
Entanglement temperature and perturbed AdS3 geometry
NASA Astrophysics Data System (ADS)
Levine, G. C.; Caravan, B.
2016-06-01
Generalizing the first law of thermodynamics, the increase in entropy density δ S (x ) of a conformal field theory (CFT) is proportional to the increase in energy density, δ E (x ) , of a subsystem divided by a spatially dependent entanglement temperature, TE(x ) , a fixed parameter determined by the geometry of the subsystem, crossing over to thermodynamic temperature at high temperatures. In this paper we derive a generalization of the thermodynamic Clausius relation, showing that deformations of the CFT by marginal operators are associated with spatial temperature variations, δ TE(x ) , and spatial energy correlations play the role of specific heat. Using AdS/CFT duality we develop a relationship between a perturbation in the local entanglement temperature of the CFT and the perturbation of the bulk AdS metric. In two dimensions, we demonstrate a method through which direct diagonalizations of the boundary quantum theory may be used to construct geometric perturbations of AdS3 .
Three dimensional nonlinear magnetic AdS solutions through topological defects
NASA Astrophysics Data System (ADS)
Hendi, S. H.; Panah, B. Eslam; Momennia, M.; Panahiyan, S.
2015-09-01
Inspired by large applications of topological defects in describing different phenomena in physics, and considering the importance of three dimensional solutions in AdS/CFT correspondence, in this paper we obtain magnetic anti-de Sitter solutions of nonlinear electromagnetic fields. We take into account three classes of nonlinear electrodynamic models; first two classes are the well-known Born-Infeld like models including logarithmic and exponential forms and third class is known as the power Maxwell invariant nonlinear electrodynamics. We investigate the effects of these nonlinear sources on three dimensional magnetic solutions. We show that these asymptotical AdS solutions do not have any curvature singularity and horizon. We also generalize the static metric to the case of rotating solutions and find that the value of the electric charge depends on the rotation parameter. Finally, we consider the quadratic Maxwell invariant as a correction of Maxwell theory and we investigate the effects of nonlinearity as a correction. We study the behavior of the deficit angle in presence of these theories of nonlinearity and compare them with each other. We also show that some cases with negative deficit angle exists which are representing objects with different geometrical structure. We also show that in case of the static only magnetic field exists whereas by boosting the metric to rotating one, electric field appears too.
SPELLING CORRECTION IN THE PUBMED SEARCH ENGINE.
Wilbur, W John; Kim, Won; Xie, Natalie
2006-11-01
It is known that users of internet search engines often enter queries with misspellings in one or more search terms. Several web search engines make suggestions for correcting misspelled words, but the methods used are proprietary and unpublished to our knowledge. Here we describe the methodology we have developed to perform spelling correction for the PubMed search engine. Our approach is based on the noisy channel model for spelling correction and makes use of statistics harvested from user logs to estimate the probabilities of different types of edits that lead to misspellings. The unique problems encountered in correcting search engine queries are discussed and our solutions are outlined. PMID:18080004
Eyeglasses for Vision Correction
... Stories Español Eye Health / Glasses & Contacts Eyeglasses for Vision Correction Dec. 12, 2015 Wearing eyeglasses is an easy way to correct refractive errors. Improving your vision with eyeglasses offers the opportunity to select from ...
Self-dual warped AdS3 black holes
NASA Astrophysics Data System (ADS)
Chen, Bin; Ning, Bo
2010-12-01
We study a new class of solutions of three-dimensional topological massive gravity. These solutions can be taken as nonextremal black holes, with their extremal counterparts being discrete quotients of spacelike warped AdS3 along the U(1)L isometry. We study the thermodynamics of these black holes and show that the first law is satisfied. We also show that for consistent boundary conditions, the asymptotic symmetry generators form only one copy of the Virasoro algebra with central charge cL=(4νℓ)/(G(ν2+3)), with which the Cardy formula reproduces the black hole entropy. We compute the real-time correlators of scalar perturbations and find a perfect match with the dual conformal field theory (CFT) predictions. Our study provides a novel example of warped AdS/CFT correspondence: the self-dual warped AdS3 black hole is dual to a CFT with nonvanishing left central charge. Moreover, our investigation suggests that the quantum topological massive gravity asymptotic to the same spacelike warped AdS3 in different consistent ways may be dual to different two-dimensional CFTs.
Correctness criteria for process migration
NASA Technical Reports Server (NTRS)
Lu, Chin; Liu, J. W. S.
1987-01-01
Two correctness criteria, the state consistency criterion and the property consistency criterion for process migration are discussed. The state machine approach is used to model the interactions between a user process and its environment. These criteria are defined in terms of the model. The idea of environment view was introduced to distinguish what a user process observes about its environment from what its environment state really is and argue that a consistent view of the environment must be maintained for every migrating process.
Research in Correctional Rehabilitation.
ERIC Educational Resources Information Center
Rehabilitation Services Administration (DHEW), Washington, DC.
Forty-three leaders in corrections and rehabilitation participated in the seminar planned to provide an indication of the status of research in correctional rehabilitation. Papers include: (1) "Program Trends in Correctional Rehabilitation" by John P. Conrad, (2) "Federal Offenders Rahabilitation Program" by Percy B. Bell and Merlyn Mathews, (3)…
NASA Astrophysics Data System (ADS)
Chubarova, N. Y.; Poliukhov, A. A.; Gorlova, I. D.
2015-07-01
The aerosol properties of the atmosphere were obtained within the framework of the AERONET program at the Moscow State University Meteorological Observatory (Moscow MSU MO) over 2001-2014 period. The quality data control has revealed the necessity of their additional cloud and NO2 correction. The application of cloud correction according to hourly visual cloud observations provides a decrease in average aerosol optical thickness (AOT) at 500 nm of up to 0.03 compared with the standard dataset. We also show that the additional NO2 correction of the AERONET data is needed in large megalopolis, like Moscow, with 12 million residents and the NOx emission rates of about 100 kt yr-1. According to the developed method we estimated monthly mean NO2 content, which provides an additional decrease of 0.01 for AOT at 340 nm, and of about 0.015 - for AOT at 380 and 440 nm. The ratios of NO2 optical thickness to AOT at 380 and 440 nm are about 5-6 % in summer and reach 15-20 % in winter when both factors have similar effects on UV irradiance. Seasonal cycle of AOT at 500 nm is characterized by a noticeable summer and spring maxima, and minimum in winter conditions, changing from 0.08 in December and January up to 0.3 in August. The application of the additional cloud correction removes a local AOT maximum in February, and lowered the December artificial high AOT values. The pronounced negative AOT trends of about -1-5 % yr-1 have been obtained for most months, which could be attributed to the negative trends in emissions (E) of different aerosol precursors of about 116 Gg yr-2 in ESOx, 78 Gg yr-2 in ENMVOC, and 272 Gg yr-2 in ECO over European territory of Russia. No influence of natural factors on temporal AOT variations has been revealed.
Planar AdS black holes in Lovelock gravity with a nonminimal scalar field
NASA Astrophysics Data System (ADS)
Gaete, Moisés Bravo; Hassaïne, Mokhtar
2013-11-01
In arbitrary dimension D, we consider a self-interacting scalar field nonminimally coupled with a gravity theory given by a particular Lovelock action indexed by an integer k. To be more precise, the coefficients appearing in the Lovelock expansion are fixed by requiring the theory to have a unique AdS vacuum with a fixed value of the cosmological constant. This yields to k = 1, 2,⋯, inequivalent possible gravity theories; here the case k = 1 corresponds to the standard Einstein-Hilbert Lagrangian. For each par ( D, k), we derive two classes of AdS black hole solutions with planar event horizon topology for particular values of the nonminimal coupling parameter. The first family of solutions depends on a unique constant and is valid only for k ≥ 2. In fact, its GR counterpart k = 1 reduces to the pure AdS metric with a vanishing scalar field. The second family of solutions involves two independent constants and corresponds to a stealth black hole configuration; that is a nontrivial scalar field together with a black hole metric such that both side of the Einstein equations (gravity and matter parts) vanishes identically. In this case, the standard GR case k = 1 reduces to the Schwarzschild-AdS-Tangherlini black hole metric with a trivial scalar field. We show that the two-parametric stealth solution defined in D dimension can be promoted to the uniparametric black hole solution in ( D + 1) dimension by fixing one of the two constants in term of the other and by adding a transversal coordinate. In both cases, the existence of these solutions is strongly inherent of the presence of the higher order curvature terms k ≥ 2 of the Lovelock gravity. We also establish that these solutions emerge from a stealth configuration defined on the pure AdS metric through a Kerr-Schild transformation. Finally, in the last part, we include multiple exact ( D - 1) - forms homogenously distributed and coupled to the scalar field. For a specific coupling, we obtain black hole
Hinrich, Anthony J; Jodelka, Francine M; Chang, Jennifer L; Brutman, Daniella; Bruno, Angela M; Briggs, Clark A; James, Bryan D; Stutzmann, Grace E; Bennett, David A; Miller, Steven A; Rigo, Frank; Marr, Robert A; Hastings, Michelle L
2016-01-01
Apolipoprotein E receptor 2 (ApoER2) is an apolipoprotein E receptor involved in long-term potentiation, learning, and memory. Given its role in cognition and its association with the Alzheimer's disease (AD) risk gene, apoE, ApoER2 has been proposed to be involved in AD, though a role for the receptor in the disease is not clear. ApoER2 signaling requires amino acids encoded by alternatively spliced exon 19. Here, we report that the balance of ApoER2 exon 19 splicing is deregulated in postmortem brain tissue from AD patients and in a transgenic mouse model of AD To test the role of deregulated ApoER2 splicing in AD, we designed an antisense oligonucleotide (ASO) that increases exon 19 splicing. Treatment of AD mice with a single dose of ASO corrected ApoER2 splicing for up to 6 months and improved synaptic function and learning and memory. These results reveal an association between ApoER2 isoform expression and AD, and provide preclinical evidence for the utility of ASOs as a therapeutic approach to mitigate Alzheimer's disease symptoms by improving ApoER2 exon 19 splicing. PMID:26902204
76 FR 59147 - Merchant Marine Personnel Advisory Committee, Correction
Federal Register 2010, 2011, 2012, 2013, 2014
2011-09-23
... INFORMATION: On August 16, 2011 (76 FR 50744), the Coast Guard published a notice of meeting for the Merchant.... ACTION: Notice of Federal Advisory Committee Meeting; correction. SUMMARY: On August 16, 2011 (76 FR... is adding a day to the meeting. This notice corrects the August 16, 2011 (76 FR 50744)...
Warped AdS3/dipole-CFT duality
NASA Astrophysics Data System (ADS)
Song, Wei; Strominger, Andrew
2012-05-01
String theory contains solutions with {{SL}}( {{2},{R}} ){{R}} × {{U}}{( {1} )_L} -invariant warped AdS3 (WAdS3) factors arising as continuous deformations of ordinary AdS3 factors. We propose that some of these are holographically dual to the IR limits of nonlocal dipole-deformed 2D D-brane gauge theories, referred to as "dipole CFTs". Neither the bulk nor boundary theories are currently well-understood, and consequences of the proposed duality for both sides is investigated. The bulk entropy-area law suggests that dipole CFTs have (at large N) a high-energy density of states which does not depend on the deformation parameter. Putting the boundary theory on a spatial circle leads to closed timelike curves in the bulk, suggesting a relation of the latter to dipole-type nonlocality.
New boundary conditions for AdS3
NASA Astrophysics Data System (ADS)
Compère, Geoffrey; Song, Wei; Strominger, Andrew
2013-05-01
New chiral boundary conditions are found for quantum gravity with matter on AdS3. The associated asymptotic symmetry group is generated by a single right-moving U(1) Kac-Moody-Virasoro algebra with {c_R}={3ℓ}/2G . The Kac-Moody zero mode generates global left-moving translations and equals, for a BTZ black hole, the sum of the total mass and spin. The level is positive about the global vacuum and negative in the black hole sector, corresponding to ergosphere formation. Realizations arising in Chern-Simons gravity and string theory are analyzed. The new boundary conditions are shown to naturally arise for warped AdS3 in the limit that the warp parameter is taken to zero.
Observing quantum gravity in asymptotically AdS space
NASA Astrophysics Data System (ADS)
Emelyanov, Slava
2015-12-01
The question is studied of whether an observer can discover quantum gravity in the semiclassical regime. It is shown that it is indeed possible to probe a certain quantum gravity effect by employing an appropriately designed detector. The effect is related to the possibility of having topologically inequivalent geometries in the path-integral approach at the same time. A conformal field theory (CFT) state which is expected to describe the eternal anti-de Sitter (AdS) black hole in the large-N limit is discussed. It is argued under certain assumptions that the black hole boundary should be merely a patch of the entire AdS boundary. This leads then to a conclusion that that CFT state is the ordinary CFT vacuum restricted to that patch. If existent, the bulk CFT operators can behave as the ordinary semiclassical quantum field theory in the large-N limit in the weak sense.
Alday-Maldacena Duality and AdS Plateau Problem
NASA Astrophysics Data System (ADS)
Morozov, A.
A short summary of approximate approach to the study of minimal surfaces in AdS, based on solving Nambu-Goto equations iteratively. Today, after partial denunciation of the BDS conjecture, this looks like the only constructive approach to understanding the ways of its possible modification and thus to saving the Alday-Maldacena duality. Numerous open technical problems are explicitly formulated throughout the text.
On information loss in AdS3/CFT2
NASA Astrophysics Data System (ADS)
Fitzpatrick, A. Liam; Kaplan, Jared; Li, Daliang; Wang, Junpu
2016-05-01
We discuss information loss from black hole physics in AdS3, focusing on two sharp signatures infecting CFT2 correlators at large central charge c: `forbidden singularities' arising from Euclidean-time periodicity due to the effective Hawking temperature, and late-time exponential decay in the Lorentzian region. We study an infinite class of examples where forbidden singularities can be resolved by non-perturbative effects at finite c, and we show that the resolution has certain universal features that also apply in the general case. Analytically continuing to the Lorentzian regime, we find that the non-perturbative effects that resolve forbidden singularities qualitatively change the behavior of correlators at times t ˜ S BH , the black hole entropy. This may resolve the exponential decay of correlators at late times in black hole backgrounds. By Borel resumming the 1 /c expansion of exact examples, we explicitly identify `information-restoring' effects from heavy states that should correspond to classical solutions in AdS3. Our results suggest a line of inquiry towards a more precise formulation of the gravitational path integral in AdS3.
Supersymmetric giant graviton solutions in AdS3
NASA Astrophysics Data System (ADS)
Mandal, Gautam; Raju, Suvrat; Smedbäck, Mikael
2008-02-01
We parametrize all classical probe brane configurations that preserve four supersymmetries in (a) the extremal D1-D5 geometry, (b) the extremal D1-D5-P geometry, (c) the smooth D1-D5 solutions proposed by Lunin and Mathur, and (d) global AdS3×S3×T4/K3. These configurations consist of D1 branes, D5 branes, and bound states of D5 and D1 branes with the property that a particular Killing vector is tangent to the brane world volume at each point. We show that the supersymmetric sector of the D5-brane world volume theory may be analyzed in an effective 1+1 dimensional framework that places it on the same footing as D1 branes. In global AdS and the corresponding Lunin-Mathur solution, the solutions we describe are “bound” to the center of AdS for generic parameters and cannot escape to infinity. We show that these probes only exist on the submanifold of moduli space where the background BNS field and theta angle vanish. We quantize these probes in the near-horizon region of the extremal D1-D5 geometry and obtain the theory of long strings discussed by Seiberg and Witten.
Numerical Simulation of Coherent Error Correction
NASA Astrophysics Data System (ADS)
Crow, Daniel; Joynt, Robert; Saffman, Mark
A major goal in quantum computation is the implementation of error correction to produce a logical qubit with an error rate lower than that of the underlying physical qubits. Recent experimental progress demonstrates physical qubits can achieve error rates sufficiently low for error correction, particularly for codes with relatively high thresholds such as the surface code and color code. Motivated by experimental capabilities of neutral atom systems, we use numerical simulation to investigate whether coherent error correction can be effectively used with the 7-qubit color code. The results indicate that coherent error correction does not work at the 10-qubit level in neutral atom array quantum computers. By adding more qubits there is a possibility of making the encoding circuits fault-tolerant which could improve performance.
Brodsky, Stanley J.; de Teramond, Guy F.; /Costa Rica U. /SLAC
2007-02-21
The AdS/CFT correspondence between string theory in AdS space and conformal .eld theories in physical spacetime leads to an analytic, semi-classical model for strongly-coupled QCD which has scale invariance and dimensional counting at short distances and color confinement at large distances. Although QCD is not conformally invariant, one can nevertheless use the mathematical representation of the conformal group in five-dimensional anti-de Sitter space to construct a first approximation to the theory. The AdS/CFT correspondence also provides insights into the inherently non-perturbative aspects of QCD, such as the orbital and radial spectra of hadrons and the form of hadronic wavefunctions. In particular, we show that there is an exact correspondence between the fifth-dimensional coordinate of AdS space z and a specific impact variable {zeta} which measures the separation of the quark and gluonic constituents within the hadron in ordinary space-time. This connection allows one to compute the analytic form of the frame-independent light-front wavefunctions, the fundamental entities which encode hadron properties and allow the computation of decay constants, form factors, and other exclusive scattering amplitudes. New relativistic lightfront equations in ordinary space-time are found which reproduce the results obtained using the 5-dimensional theory. The effective light-front equations possess remarkable algebraic structures and integrability properties. Since they are complete and orthonormal, the AdS/CFT model wavefunctions can also be used as a basis for the diagonalization of the full light-front QCD Hamiltonian, thus systematically improving the AdS/CFT approximation.