Sample records for additional factors required

  1. 10 CFR 20.2302 - Additional requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Additional requirements. 20.2302 Section 20.2302 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Exemptions and Additional Requirements § 20.2302 Additional requirements. The Commission may, by rule, regulation, or order, impose...

  2. 10 CFR 20.2302 - Additional requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Additional requirements. 20.2302 Section 20.2302 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Exemptions and Additional Requirements § 20.2302 Additional requirements. The Commission may, by rule, regulation, or order, impose...

  3. 10 CFR 20.2302 - Additional requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Additional requirements. 20.2302 Section 20.2302 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Exemptions and Additional Requirements § 20.2302 Additional requirements. The Commission may, by rule, regulation, or order, impose...

  4. 10 CFR 55.7 - Additional requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Additional requirements. 55.7 Section 55.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES General Provisions § 55.7 Additional requirements. The Commission may, by rule, regulation, or order, impose upon any licensee such requirements, in addition to...

  5. 10 CFR 55.7 - Additional requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Additional requirements. 55.7 Section 55.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES General Provisions § 55.7 Additional requirements. The Commission may, by rule, regulation, or order, impose upon any licensee such requirements, in addition to...

  6. 7 CFR 3015.161 - Additional requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Additional requirements. 3015.161 Section 3015.161 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER, DEPARTMENT OF AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Property § 3015.161 Additional requirements...

  7. 42 CFR 417.592 - Additional benefits requirement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Additional benefits requirement. 417.592 Section... HEALTH CARE PREPAYMENT PLANS Medicare Payment: Risk Basis § 417.592 Additional benefits requirement. (a... benefits. Provide its Medicare enrollees with additional benefits in accordance with paragraph (c) of this...

  8. 42 CFR 493.557 - Additional submission requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... scope of the specialty or subspecialty areas. (2) A description of the organization's data management..., Nonprofit Accreditation Organization or Exemption Under an Approved State Laboratory Program § 493.557 Additional submission requirements. (a) Specific requirements for accreditation organizations. In addition to...

  9. 10 CFR 70.74 - Additional reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Additional reporting requirements. 70.74 Section 70.74 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DOMESTIC LICENSING OF SPECIAL NUCLEAR MATERIAL Additional Requirements for Certain Licensees Authorized To Possess a Critical Mass of Special Nuclear...

  10. 46 CFR 133.07 - Additional equipment and requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Additional equipment and requirements. 133.07 Section 133.07 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS LIFESAVING SYSTEMS General § 133.07 Additional equipment and requirements. The OCMI may require an OSV to...

  11. 46 CFR 133.07 - Additional equipment and requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Additional equipment and requirements. 133.07 Section 133.07 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS LIFESAVING SYSTEMS General § 133.07 Additional equipment and requirements. The OCMI may require an OSV to...

  12. 33 CFR 155.1125 - Additional response plan requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Additional response plan... Additional Response Plan Requirements for Tankers Loading Cargo at a Facility Permitted Under the Trans-Alaska Pipeline Authorization Act § 155.1125 Additional response plan requirements. (a) The owner or...

  13. 33 CFR 155.1125 - Additional response plan requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Additional response plan... Additional Response Plan Requirements for Tankers Loading Cargo at a Facility Permitted Under the Trans-Alaska Pipeline Authorization Act § 155.1125 Additional response plan requirements. (a) The owner or...

  14. 33 CFR 155.1125 - Additional response plan requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Additional response plan... Additional Response Plan Requirements for Tankers Loading Cargo at a Facility Permitted Under the Trans-Alaska Pipeline Authorization Act § 155.1125 Additional response plan requirements. (a) The owner or...

  15. 42 CFR 417.592 - Additional benefits requirement.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Additional benefits requirement. 417.592 Section... PLANS, AND HEALTH CARE PREPAYMENT PLANS Medicare Payment: Risk Basis § 417.592 Additional benefits...) Additional benefits. Provide its Medicare enrollees with additional benefits in accordance with paragraph (c...

  16. 29 CFR 1602.37 - Additional reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Report § 1602.37 Additional reporting requirements. The Commission reserves the right to require reports... employment practices of individual political jurisdictions or group of political jurisdictions whenever, in...

  17. 14 CFR 1203.406 - Additional classification factors.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... PROGRAM Guides for Original Classification § 1203.406 Additional classification factors. In determining the appropriate classification category, the following additional factors should be considered: (a... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Additional classification factors. 1203.406...

  18. 48 CFR 27.406-2 - Additional data requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Additional data... GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Data and Copyrights 27.406-2 Additional data requirements. (a) In some contracting situations, such as experimental, developmental...

  19. 48 CFR 27.406-2 - Additional data requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Additional data... GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Data and Copyrights 27.406-2 Additional data requirements. (a) In some contracting situations, such as experimental, developmental...

  20. 46 CFR 11.502 - Additional requirements for engineer endorsements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Additional requirements for engineer endorsements. 11... SEAMEN REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.502 Additional requirements for engineer endorsements. (a) For all original and raise of grade of engineer...

  1. 46 CFR 11.502 - Additional requirements for engineer endorsements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Additional requirements for engineer endorsements. 11... SEAMEN REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.502 Additional requirements for engineer endorsements. (a) For all original and raise of grade of engineer...

  2. 46 CFR 11.502 - Additional requirements for engineer endorsements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Additional requirements for engineer endorsements. 11... SEAMEN REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.502 Additional requirements for engineer endorsements. (a) For all original and raise of grade of engineer...

  3. 46 CFR 11.502 - Additional requirements for engineer endorsements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Additional requirements for engineer endorsements. 11... SEAMEN REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.502 Additional requirements for engineer endorsements. (a) For all original and raise of grade of engineer...

  4. 40 CFR 141.154 - Required additional health information.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 24 2012-07-01 2012-07-01 false Required additional health information... Required additional health information. (a) All reports must prominently display the following language... from their health care providers. EPA/CDC guidelines on appropriate means to lessen the risk of...

  5. 40 CFR 141.154 - Required additional health information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Required additional health information... Required additional health information. (a) All reports must prominently display the following language... from their health care providers. EPA/CDC guidelines on appropriate means to lessen the risk of...

  6. 40 CFR 141.154 - Required additional health information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Required additional health information... Required additional health information. (a) All reports must prominently display the following language... from their health care providers. EPA/CDC guidelines on appropriate means to lessen the risk of...

  7. 40 CFR 141.154 - Required additional health information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 24 2013-07-01 2013-07-01 false Required additional health information... Required additional health information. (a) All reports must prominently display the following language... from their health care providers. EPA/CDC guidelines on appropriate means to lessen the risk of...

  8. 46 CFR 15.525 - Additional manning requirements for tank vessels.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Additional manning requirements for tank vessels. 15.525... MANNING REQUIREMENTS Manning Requirements; Inspected Vessels § 15.525 Additional manning requirements for tank vessels. Parts 31 and 35 of this chapter contain additional manning requirements applicable to...

  9. 33 CFR 104.295 - Additional requirements-cruise ships.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Additional requirements-cruise ships. 104.295 Section 104.295 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARITIME SECURITY: VESSELS Vessel Security Requirements § 104.295 Additional requirements—cruise ships. (a) At all MARSEC...

  10. 40 CFR 63.504 - Additional requirements for performance testing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Additional requirements for performance... Additional requirements for performance testing. (a) Performance testing shall be conducted in accordance.... Sections 63.484 through 63.501 also contain specific testing requirements. (1) Performance tests shall be...

  11. 49 CFR 172.203 - Additional description requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., TRAINING REQUIREMENTS, AND SECURITY PLANS Shipping Papers § 172.203 Additional description requirements. (a) Special permits. Except as provided in § 173.23 of this subchapter, each shipping paper issued in... to which the special permit applies. Each shipping paper issued in connection with a shipment made...

  12. 49 CFR 172.203 - Additional description requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., TRAINING REQUIREMENTS, AND SECURITY PLANS Shipping Papers § 172.203 Additional description requirements. (a) Special permits. Except as provided in § 173.23 of this subchapter, each shipping paper issued in... to which the special permit applies. Each shipping paper issued in connection with a shipment made...

  13. 49 CFR 172.203 - Additional description requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., TRAINING REQUIREMENTS, AND SECURITY PLANS Shipping Papers § 172.203 Additional description requirements. (a) Special permits. Except as provided in § 173.23 of this subchapter, each shipping paper issued in... to which the special permit applies. Each shipping paper issued in connection with a shipment made...

  14. 49 CFR 172.203 - Additional description requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., TRAINING REQUIREMENTS, AND SECURITY PLANS Shipping Papers § 172.203 Additional description requirements. (a) Special permits. Except as provided in § 173.23 of this subchapter, each shipping paper issued in... to which the special permit applies. Each shipping paper issued in connection with a shipment made...

  15. 15 CFR 292.6 - Additional requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Additional requirements. 292.6 Section 292.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS MANUFACTURING EXTENSION...

  16. 15 CFR 292.6 - Additional requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Additional requirements. 292.6 Section 292.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS MANUFACTURING EXTENSION...

  17. 15 CFR 292.6 - Additional requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Additional requirements. 292.6 Section 292.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS MANUFACTURING EXTENSION...

  18. 15 CFR 292.6 - Additional requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Additional requirements. 292.6 Section 292.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS MANUFACTURING EXTENSION...

  19. 15 CFR 292.6 - Additional requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Additional requirements. 292.6 Section 292.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS MANUFACTURING EXTENSION...

  20. 33 CFR 154.1125 - Additional response plan requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Additional response plan... SECURITY (CONTINUED) POLLUTION FACILITIES TRANSFERRING OIL OR HAZARDOUS MATERIAL IN BULK Additional... Prince William Sound, Alaska § 154.1125 Additional response plan requirements. (a) The owner or operator...

  1. 33 CFR 203.83 - Additional requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Additional requirements. 203.83 Section 203.83 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE EMERGENCY EMPLOYMENT OF ARMY AND OTHER RESOURCES, NATURAL DISASTER PROCEDURES Local Interests...

  2. 33 CFR 203.83 - Additional requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Additional requirements. 203.83 Section 203.83 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE EMERGENCY EMPLOYMENT OF ARMY AND OTHER RESOURCES, NATURAL DISASTER PROCEDURES Local Interests...

  3. 33 CFR 203.83 - Additional requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Additional requirements. 203.83 Section 203.83 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE EMERGENCY EMPLOYMENT OF ARMY AND OTHER RESOURCES, NATURAL DISASTER PROCEDURES Local Interests...

  4. 33 CFR 203.83 - Additional requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Additional requirements. 203.83 Section 203.83 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE EMERGENCY EMPLOYMENT OF ARMY AND OTHER RESOURCES, NATURAL DISASTER PROCEDURES Local Interests...

  5. 27 CFR 18.27 - Additional requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Additional requirements. 18.27 Section 18.27 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Qualification Application...

  6. 27 CFR 18.27 - Additional requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Additional requirements. 18.27 Section 18.27 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Qualification Application...

  7. 27 CFR 18.27 - Additional requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Additional requirements. 18.27 Section 18.27 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Qualification Application...

  8. 27 CFR 18.27 - Additional requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Additional requirements. 18.27 Section 18.27 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Qualification Application...

  9. 27 CFR 18.27 - Additional requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Additional requirements. 18.27 Section 18.27 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Qualification Application...

  10. 18 CFR 154.400 - Additional requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Additional requirements. 154.400 Section 154.400 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT RATE SCHEDULES AND TARIFFS Limited Rate Changes § 154...

  11. 18 CFR 154.400 - Additional requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Additional requirements. 154.400 Section 154.400 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT RATE SCHEDULES AND TARIFFS Limited Rate Changes § 154...

  12. 18 CFR 154.400 - Additional requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Additional requirements. 154.400 Section 154.400 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT RATE SCHEDULES AND TARIFFS Limited Rate Changes § 154...

  13. 18 CFR 154.400 - Additional requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Additional requirements. 154.400 Section 154.400 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT RATE SCHEDULES AND TARIFFS Limited Rate Changes § 154...

  14. 18 CFR 154.400 - Additional requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Additional requirements. 154.400 Section 154.400 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT RATE SCHEDULES AND TARIFFS Limited Rate Changes § 154...

  15. 33 CFR 105.290 - Additional requirements-cruise ship terminals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Additional requirements-cruise ship terminals. 105.290 Section 105.290 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARITIME SECURITY: FACILITIES Facility Security Requirements § 105.290 Additional requirements—cruise ship terminals...

  16. 29 CFR 1926.1421 - Signals-voice signals-additional requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 8 2013-07-01 2013-07-01 false Signals-voice signals-additional requirements. 1926.1421... Derricks in Construction § 1926.1421 Signals—voice signals—additional requirements. (a) Prior to beginning operations, the operator, signal person and lift director (if there is one), must contact each other and...

  17. 29 CFR 1926.1421 - Signals-voice signals-additional requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 8 2014-07-01 2014-07-01 false Signals-voice signals-additional requirements. 1926.1421... Derricks in Construction § 1926.1421 Signals—voice signals—additional requirements. (a) Prior to beginning operations, the operator, signal person and lift director (if there is one), must contact each other and...

  18. 29 CFR 1926.1421 - Signals-voice signals-additional requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 8 2012-07-01 2012-07-01 false Signals-voice signals-additional requirements. 1926.1421... Derricks in Construction § 1926.1421 Signals—voice signals—additional requirements. (a) Prior to beginning operations, the operator, signal person and lift director (if there is one), must contact each other and...

  19. 10 CFR 70.74 - Additional reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Additional Requirements for Certain Licensees Authorized To Possess a Critical Mass of Special Nuclear... subpart is complete. (5) Each licensee shall provide reasonable assurance that reliable communication with...

  20. 40 CFR 503.5 - Additional or more stringent requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements. 503.5 Section 503.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SEWAGE SLUDGE STANDARDS FOR THE USE OR DISPOSAL OF SEWAGE SLUDGE General Provisions § 503.5 Additional or more... the use or disposal of sewage sludge in addition to or more stringent than the requirements in this...

  1. Risk factors for an additional port in single-incision laparoscopic cholecystectomy in patients with cholecystitis.

    PubMed

    Araki, Kenichiro; Shirabe, Ken; Watanabe, Akira; Kubo, Norio; Sasaki, Shigeru; Suzuki, Hideki; Asao, Takayuki; Kuwano, Hiroyuki

    2017-01-01

    Although single-incision laparoscopic cholecystectomy is now widely performed in patients with cholecystitis, some cases require an additional port to complete the procedure. In this study, we focused on risk factor of additional port in this surgery. We performed single-incision cholecystectomy in 75 patients with acute cholecystitis or after cholecystitis between 2010 and 2014 at Gunma University Hospital. Surgical indications followed the TG13 guidelines. Our standard procedure for single-incision cholecystectomy routinely uses two needlescopic devices. We used logistic regression analysis to identify the risk factors associated with use of an additional full-size port (5 or 10 mm). Surgical outcome was acceptable without biliary injury. Nine patients (12.0%) required an additional port, and one patient (1.3%) required conversion to open cholecystectomy because of severe adhesions around the cystic duct and common bile duct. In multivariate analysis, high C-reactive protein (CRP) values (>7.0 mg/dl) during cholecystitis attacks were significantly correlated with the need for an additional port (P = 0.009), with a sensitivity of 55.6%, specificity of 98.5%, and accuracy of 93.3%. This study indicated that the severe inflammation indicated by high CRP values during cholecystitis attacks predicts the need for an additional port. J. Med. Invest. 64: 245-249, August, 2017.

  2. 40 CFR 161.75 - Requirements for additional data.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Requirements for additional data. 161.75 Section 161.75 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES General Provisions § 161.75...

  3. 46 CFR 199.07 - Additional equipment and requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Additional equipment and requirements. 199.07 Section 199.07 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LIFESAVING APPLIANCES AND ARRANGEMENTS LIFESAVING SYSTEMS FOR CERTAIN INSPECTED VESSELS General § 199.07 Additional equipment and...

  4. 46 CFR 35.03-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Additional requirements for hybrid work vests. 35.03-25 Section 35.03-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS OPERATIONS Work Vests § 35.03-25 Additional requirements for hybrid work vests. (a) In addition to the other requirements in...

  5. 46 CFR 35.03-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Additional requirements for hybrid work vests. 35.03-25 Section 35.03-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS OPERATIONS Work Vests § 35.03-25 Additional requirements for hybrid work vests. (a) In addition to the other requirements in...

  6. 46 CFR 35.03-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Additional requirements for hybrid work vests. 35.03-25 Section 35.03-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS OPERATIONS Work Vests § 35.03-25 Additional requirements for hybrid work vests. (a) In addition to the other requirements in...

  7. 46 CFR 35.03-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Additional requirements for hybrid work vests. 35.03-25 Section 35.03-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS OPERATIONS Work Vests § 35.03-25 Additional requirements for hybrid work vests. (a) In addition to the other requirements in...

  8. 46 CFR 35.03-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Additional requirements for hybrid work vests. 35.03-25 Section 35.03-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS OPERATIONS Work Vests § 35.03-25 Additional requirements for hybrid work vests. (a) In addition to the other requirements in...

  9. 46 CFR 72.01-25 - Additional structural requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONSTRUCTION AND ARRANGEMENT Hull Structure § 72.01-25 Additional structural requirements. (a) Vessels required.... The construction of the bulkheads shall be to the satisfaction of the Commandant. (2) Steps and... deck, such bulkhead or deck shall be made structurally watertight without the use of wood, cement, or...

  10. 14 CFR 136.5 - Additional requirements for Hawaii.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Additional requirements for Hawaii. 136.5 Section 136.5 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... requirements for Hawaii. No person may conduct a commercial air tour in the State of Hawaii unless they comply...

  11. 49 CFR 236.1007 - Additional requirements for high-speed service.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Additional requirements for high-speed service. 236.1007 Section 236.1007 Transportation Other Regulations Relating to Transportation (Continued..., AND APPLIANCES Positive Train Control Systems § 236.1007 Additional requirements for high-speed...

  12. Factor requirements for transcription in the Archaeon Sulfolobus shibatae.

    PubMed

    Qureshi, S A; Bell, S D; Jackson, S P

    1997-05-15

    Archaea (archaebacteria) constitute a domain of life that is distinct from Bacteria (eubacteria) and Eucarya (eukaryotes). Although archaeal cells share many morphological features with eubacteria, their transcriptional apparatus is more akin to eukaryotic RNA polymerases I, II and III than it is to eubacterial transcription systems. Thus, in addition to possessing a 10 subunit RNA polymerase and a homologue of the TATA-binding protein (TBP), Archaea possess a polypeptide termed TFB that is homologous to eukaryotic TFIIB. Here, we investigate the factor requirements for transcription of several promoters of the archaeon Sulfolobus shibatae and its associated virus SSV. Through in vitro transcription and immunodepletion, we demonstrate that S. shibatae TBP, TFB and RNA polymerase are not complexed tightly with one another and that each is required for efficient transcription of all promoters tested. Furthermore, full transcription is restored by supplementing respective depleted extracts with recombinant TBP or TFB, indicating that TBP-associated factors or TFB-associated factors are not required. Indeed, gel-filtration suggests that Sulfolobus TBP and TFB are not associated stably with other proteins. Finally, all promoters analysed are transcribed accurately and efficiently in an in vitro system comprising recombinant TBP and TFB, together with essentially homogeneous preparation of RNA polymerase. Transcription in Archaea is therefore fundamentally homologous to that in eukaryotes, although factor requirements appear to be much less complex.

  13. 49 CFR 236.1007 - Additional requirements for high-speed service.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Additional requirements for high-speed service..., AND APPLIANCES Positive Train Control Systems § 236.1007 Additional requirements for high-speed... by this subpart, and which have been utilized on high-speed rail systems with similar technical and...

  14. 46 CFR 160.027-3 - Additional requirements for life floats.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Additional requirements for life floats. 160.027-3..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Life Floats for Merchant Vessels § 160.027-3 Additional requirements for life floats. (a) Each life float must have a platform designed...

  15. 46 CFR 160.027-3 - Additional requirements for life floats.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 6 2011-10-01 2011-10-01 false Additional requirements for life floats. 160.027-3..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Life Floats for Merchant Vessels § 160.027-3 Additional requirements for life floats. (a) Each life float must have a platform designed...

  16. 37 CFR 2.23 - Additional requirements for TEAS Plus application.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... TEAS Plus application. 2.23 Section 2.23 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND... § 2.23 Additional requirements for TEAS Plus application. (a) In addition to the filing requirements under § 2.22(a), the applicant must: (1) File the following communications through TEAS: (i) Responses...

  17. 46 CFR 160.027-3 - Additional requirements for life floats.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 6 2014-10-01 2014-10-01 false Additional requirements for life floats. 160.027-3..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Life Floats for Merchant Vessels § 160.027-3 Additional requirements for life floats. (a) Each life float must have a platform designed...

  18. 46 CFR 160.027-3 - Additional requirements for life floats.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 6 2013-10-01 2013-10-01 false Additional requirements for life floats. 160.027-3..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Life Floats for Merchant Vessels § 160.027-3 Additional requirements for life floats. (a) Each life float must have a platform designed...

  19. 46 CFR 160.027-3 - Additional requirements for life floats.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 6 2012-10-01 2012-10-01 false Additional requirements for life floats. 160.027-3..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Life Floats for Merchant Vessels § 160.027-3 Additional requirements for life floats. (a) Each life float must have a platform designed...

  20. 37 CFR 2.23 - Additional requirements for TEAS Plus application.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... TEAS Plus application. 2.23 Section 2.23 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND... § 2.23 Additional requirements for TEAS Plus application. (a) In addition to the filing requirements under § 2.22(a), the applicant must: (1) File the following communications through TEAS: (i) Responses...

  1. 12 CFR 229.18 - Additional disclosure requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... RESERVE SYSTEM AVAILABILITY OF FUNDS AND COLLECTION OF CHECKS (REGULATION CC) Availability of Funds and Disclosure of Funds Availability Policies § 229.18 Additional disclosure requirements. (a) Deposit slips. A... consumer accounts a notice that sets forth the time periods applicable to the availability of funds...

  2. 12 CFR 229.18 - Additional disclosure requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... RESERVE SYSTEM AVAILABILITY OF FUNDS AND COLLECTION OF CHECKS (REGULATION CC) Availability of Funds and Disclosure of Funds Availability Policies § 229.18 Additional disclosure requirements. (a) Deposit slips. A... consumer accounts a notice that sets forth the time periods applicable to the availability of funds...

  3. 30 CFR 75.1103-10 - Fire suppression systems; additional requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements. 75.1103-10 Section 75.1103-10 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT... Protection § 75.1103-10 Fire suppression systems; additional requirements. For each conveyor belt flight... per minute, an additional cache of the materials specified in § 75.1103-9(a)(1), (2), and (3) shall be...

  4. 24 CFR 235.1218 - Additional eligibility requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...; Direct Endorsement § 235.1218 Additional eligibility requirements. (a) Mortgage amount. It must be in an... par on one of the following dates, whichever rate is higher: (i) The date the Direct Endorsement mortgagee's underwriter signs the Mortgage Credit Analysis Worksheet (form HUD-92900 WS); or (ii) The date...

  5. 48 CFR 1352.271-72 - Additional Item Requirements (AIR)-growth work

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Requirements (AIR)-growth work 1352.271-72 Section 1352.271-72 Federal Acquisition Regulations System... Clauses 1352.271-72 Additional Item Requirements (AIR)—growth work As prescribed in 48 CFR 1371.103, insert the following clause: Additional Item Requirements (Air)—Growth Work (APR 2010) (a) This clause...

  6. 21 CFR 1311.115 - Additional requirements for two-factor authentication.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) separate from the computer to which the practitioner is gaining access. (b) If one factor is a hard token, it must be separate from the computer to which it is gaining access and must meet at least the criteria of FIPS 140-2 Security Level 1, as incorporated by reference in § 1311.08, for cryptographic...

  7. 21 CFR 1311.115 - Additional requirements for two-factor authentication.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) separate from the computer to which the practitioner is gaining access. (b) If one factor is a hard token, it must be separate from the computer to which it is gaining access and must meet at least the criteria of FIPS 140-2 Security Level 1, as incorporated by reference in § 1311.08, for cryptographic...

  8. 21 CFR 1311.115 - Additional requirements for two-factor authentication.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) separate from the computer to which the practitioner is gaining access. (b) If one factor is a hard token, it must be separate from the computer to which it is gaining access and must meet at least the criteria of FIPS 140-2 Security Level 1, as incorporated by reference in § 1311.08, for cryptographic...

  9. 21 CFR 1311.115 - Additional requirements for two-factor authentication.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) separate from the computer to which the practitioner is gaining access. (b) If one factor is a hard token, it must be separate from the computer to which it is gaining access and must meet at least the criteria of FIPS 140-2 Security Level 1, as incorporated by reference in § 1311.08, for cryptographic...

  10. 21 CFR 1311.115 - Additional requirements for two-factor authentication.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) separate from the computer to which the practitioner is gaining access. (b) If one factor is a hard token, it must be separate from the computer to which it is gaining access and must meet at least the criteria of FIPS 140-2 Security Level 1, as incorporated by reference in § 1311.08, for cryptographic...

  11. 46 CFR 196.34-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Additional requirements for hybrid work vests. 196.34-25 Section 196.34-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS OPERATIONS Work Vests § 196.34-25 Additional requirements for hybrid work vests. (a) In addition...

  12. 46 CFR 196.34-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Additional requirements for hybrid work vests. 196.34-25 Section 196.34-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS OPERATIONS Work Vests § 196.34-25 Additional requirements for hybrid work vests. (a) In addition...

  13. 46 CFR 196.34-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Additional requirements for hybrid work vests. 196.34-25 Section 196.34-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS OPERATIONS Work Vests § 196.34-25 Additional requirements for hybrid work vests. (a) In addition...

  14. 46 CFR 196.34-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Additional requirements for hybrid work vests. 196.34-25 Section 196.34-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS OPERATIONS Work Vests § 196.34-25 Additional requirements for hybrid work vests. (a) In addition...

  15. 46 CFR 196.34-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Additional requirements for hybrid work vests. 196.34-25 Section 196.34-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS OPERATIONS Work Vests § 196.34-25 Additional requirements for hybrid work vests. (a) In addition...

  16. 24 CFR 235.1218 - Additional eligibility requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Additional eligibility requirements... interest due and delinquent interest not to exceed two months; and (2) The original principal amount of the... based on the closing price for three-month forward delivery contracts closest to par but not exceeding...

  17. 25 CFR 215.17 - Additional information required.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Additional information required. 215.17 Section 215.17 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEAD AND ZINC MINING... application, must file one certified copy of articles of incorporation and, if a foreign corporation, evidence...

  18. 46 CFR 97.34-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Additional requirements for hybrid work vests. 97.34-25 Section 97.34-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Work Vests § 97.34-25 Additional requirements for hybrid work vests. (a) In addition to...

  19. 46 CFR 97.34-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Additional requirements for hybrid work vests. 97.34-25 Section 97.34-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Work Vests § 97.34-25 Additional requirements for hybrid work vests. (a) In addition to...

  20. 46 CFR 78.36-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 3 2011-10-01 2011-10-01 false Additional requirements for hybrid work vests. 78.36-25 Section 78.36-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS OPERATIONS Work Vests § 78.36-25 Additional requirements for hybrid work vests. (a) In addition to the other...

  1. 46 CFR 78.36-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Additional requirements for hybrid work vests. 78.36-25 Section 78.36-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS OPERATIONS Work Vests § 78.36-25 Additional requirements for hybrid work vests. (a) In addition to the other...

  2. 46 CFR 97.34-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Additional requirements for hybrid work vests. 97.34-25 Section 97.34-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Work Vests § 97.34-25 Additional requirements for hybrid work vests. (a) In addition to...

  3. 46 CFR 78.36-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 3 2014-10-01 2014-10-01 false Additional requirements for hybrid work vests. 78.36-25 Section 78.36-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS OPERATIONS Work Vests § 78.36-25 Additional requirements for hybrid work vests. (a) In addition to the other...

  4. 46 CFR 97.34-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Additional requirements for hybrid work vests. 97.34-25 Section 97.34-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Work Vests § 97.34-25 Additional requirements for hybrid work vests. (a) In addition to...

  5. 46 CFR 78.36-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 3 2013-10-01 2013-10-01 false Additional requirements for hybrid work vests. 78.36-25 Section 78.36-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS OPERATIONS Work Vests § 78.36-25 Additional requirements for hybrid work vests. (a) In addition to the other...

  6. 46 CFR 78.36-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 3 2012-10-01 2012-10-01 false Additional requirements for hybrid work vests. 78.36-25 Section 78.36-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS OPERATIONS Work Vests § 78.36-25 Additional requirements for hybrid work vests. (a) In addition to the other...

  7. 46 CFR 97.34-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Additional requirements for hybrid work vests. 97.34-25 Section 97.34-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Work Vests § 97.34-25 Additional requirements for hybrid work vests. (a) In addition to...

  8. 25 CFR 215.17 - Additional information required.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... interested in lead and zinc mining leases, or land under the jurisdiction of the Quapaw Indian Agency, and... 25 Indians 1 2010-04-01 2010-04-01 false Additional information required. 215.17 Section 215.17 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEAD AND ZINC MINING...

  9. 46 CFR 42.09-30 - Additional survey requirements for steel-hull vessels.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 2 2011-10-01 2011-10-01 false Additional survey requirements for steel-hull vessels...-30 Additional survey requirements for steel-hull vessels. (a) In addition to the requirements in § 42..., peaks, bilges, machinery spaces, and bunkers shall be examined to determine the condition of the framing...

  10. 46 CFR 42.09-30 - Additional survey requirements for steel-hull vessels.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 2 2012-10-01 2012-10-01 false Additional survey requirements for steel-hull vessels. 42.09-30 Section 42.09-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD...-30 Additional survey requirements for steel-hull vessels. (a) In addition to the requirements in § 42...

  11. 46 CFR 42.09-30 - Additional survey requirements for steel-hull vessels.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 2 2014-10-01 2014-10-01 false Additional survey requirements for steel-hull vessels. 42.09-30 Section 42.09-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD...-30 Additional survey requirements for steel-hull vessels. (a) In addition to the requirements in § 42...

  12. 46 CFR 42.09-30 - Additional survey requirements for steel-hull vessels.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 2 2013-10-01 2013-10-01 false Additional survey requirements for steel-hull vessels. 42.09-30 Section 42.09-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD...-30 Additional survey requirements for steel-hull vessels. (a) In addition to the requirements in § 42...

  13. 46 CFR 42.09-35 - Additional survey requirements for wood-hull vessels.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 2 2013-10-01 2013-10-01 false Additional survey requirements for wood-hull vessels. 42.09-35 Section 42.09-35 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES... Additional survey requirements for wood-hull vessels. (a) In addition to the requirements in § 42.09-25, the...

  14. 46 CFR 42.09-35 - Additional survey requirements for wood-hull vessels.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 2 2012-10-01 2012-10-01 false Additional survey requirements for wood-hull vessels. 42.09-35 Section 42.09-35 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES... Additional survey requirements for wood-hull vessels. (a) In addition to the requirements in § 42.09-25, the...

  15. 46 CFR 42.09-35 - Additional survey requirements for wood-hull vessels.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 2 2014-10-01 2014-10-01 false Additional survey requirements for wood-hull vessels. 42.09-35 Section 42.09-35 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES... Additional survey requirements for wood-hull vessels. (a) In addition to the requirements in § 42.09-25, the...

  16. 46 CFR 42.09-35 - Additional survey requirements for wood-hull vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Additional survey requirements for wood-hull vessels. 42.09-35 Section 42.09-35 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES... Additional survey requirements for wood-hull vessels. (a) In addition to the requirements in § 42.09-25, the...

  17. 46 CFR 42.09-30 - Additional survey requirements for steel-hull vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Additional survey requirements for steel-hull vessels...-30 Additional survey requirements for steel-hull vessels. (a) In addition to the requirements in § 42...) When the vessel is in drydock, the hull plating, etc., shall be examined. (c) The holds, 'tween decks...

  18. 46 CFR 42.09-35 - Additional survey requirements for wood-hull vessels.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 2 2011-10-01 2011-10-01 false Additional survey requirements for wood-hull vessels. 42.09-35 Section 42.09-35 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES... Additional survey requirements for wood-hull vessels. (a) In addition to the requirements in § 42.09-25, the...

  19. Intracellular Trafficking and Persistence of Acinetobacter baumannii Requires Transcription Factor EB

    PubMed Central

    Parra-Millán, Raquel; Guerrero-Gómez, David; Ayerbe-Algaba, Rafael; Pachón-Ibáñez, Maria Eugenia; Miranda-Vizuete, Antonio

    2018-01-01

    ABSTRACT Acinetobacter baumannii is a significant human pathogen associated with hospital-acquired infections. While adhesion, an initial and important step in A. baumannii infection, is well characterized, the intracellular trafficking of this pathogen inside host cells remains poorly studied. Here, we demonstrate that transcription factor EB (TFEB) is activated after A. baumannii infection of human lung epithelial cells (A549). We also show that TFEB is required for the invasion and persistence inside A549 cells. Consequently, lysosomal biogenesis and autophagy activation were observed after TFEB activation which could increase the death of A549 cells. In addition, using the Caenorhabditis elegans infection model by A. baumannii, the TFEB orthologue HLH-30 was required for survival of the nematode to infection, although nuclear translocation of HLH-30 was not required. These results identify TFEB as a conserved key factor in the pathogenesis of A. baumannii. IMPORTANCE Adhesion is an initial and important step in Acinetobacter baumannii infections. However, the mechanism of entrance and persistence inside host cells is unclear and remains to be understood. In this study, we report that, in addition to its known role in host defense against Gram-positive bacterial infection, TFEB also plays an important role in the intracellular trafficking of A. baumannii in host cells. TFEB was activated shortly after A. baumannii infection and is required for its persistence within host cells. Additionally, using the C. elegans infection model by A. baumannii, the TFEB orthologue HLH-30 was required for survival of the nematode to infection, although nuclear translocation of HLH-30 was not required. PMID:29600279

  20. 46 CFR 95.17-25 - Additional protection required.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... FIRE PROTECTION EQUIPMENT Foam Extinguishing Systems, Details § 95.17-25 Additional protection required. (a) In order that any residual fires above the floor plates may be extinguished when a foam system is...

  1. 46 CFR 76.17-25 - Additional protection required.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... PROTECTION EQUIPMENT Foam Extinguishing Systems, Details § 76.17-25 Additional protection required. (a) In order that any residual fires above the floor plates may be extinguished when a foam system is installed...

  2. 46 CFR 95.17-25 - Additional protection required.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... FIRE PROTECTION EQUIPMENT Foam Extinguishing Systems, Details § 95.17-25 Additional protection required. (a) In order that any residual fires above the floor plates may be extinguished when a foam system is...

  3. 46 CFR 76.17-25 - Additional protection required.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PROTECTION EQUIPMENT Foam Extinguishing Systems, Details § 76.17-25 Additional protection required. (a) In order that any residual fires above the floor plates may be extinguished when a foam system is installed...

  4. 33 CFR 105.290 - Additional requirements-cruise ship terminals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Additional requirements-cruise ship terminals. 105.290 Section 105.290 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Additional requirements—cruise ship terminals. At all MARSEC Levels, in coordination with a vessel moored at...

  5. 33 CFR 105.290 - Additional requirements-cruise ship terminals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Additional requirements-cruise ship terminals. 105.290 Section 105.290 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Additional requirements—cruise ship terminals. At all MARSEC Levels, in coordination with a vessel moored at...

  6. 33 CFR 105.290 - Additional requirements-cruise ship terminals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Additional requirements-cruise ship terminals. 105.290 Section 105.290 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Additional requirements—cruise ship terminals. At all MARSEC Levels, in coordination with a vessel moored at...

  7. 33 CFR 105.290 - Additional requirements-cruise ship terminals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Additional requirements-cruise ship terminals. 105.290 Section 105.290 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Additional requirements—cruise ship terminals. At all MARSEC Levels, in coordination with a vessel moored at...

  8. 14 CFR 61.31 - Type rating requirements, additional training, and authorization requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... holder is already qualified. (k) Additional training required for night vision goggle operations. (1... aircraft using night vision goggles only if that person receives and logs ground training from an...: (i) Applicable portions of this chapter that relate to night vision goggle limitations and flight...

  9. 14 CFR 61.31 - Type rating requirements, additional training, and authorization requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... holder is already qualified. (k) Additional training required for night vision goggle operations. (1... aircraft using night vision goggles only if that person receives and logs ground training from an...: (i) Applicable portions of this chapter that relate to night vision goggle limitations and flight...

  10. 45 CFR 162.925 - Additional requirements for health plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Additional requirements for health plans. 162.925 Section 162.925 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES ADMINISTRATIVE DATA STANDARDS AND... requirements for health plans. (a) General rules. (1) If an entity requests a health plan to conduct a...

  11. 45 CFR 162.925 - Additional requirements for health plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Additional requirements for health plans. 162.925 Section 162.925 Public Welfare Department of Health and Human Services ADMINISTRATIVE DATA STANDARDS AND... requirements for health plans. (a) General rules. (1) If an entity requests a health plan to conduct a...

  12. 45 CFR 162.925 - Additional requirements for health plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... clearinghouse to receive, process, or transmit a standard transaction may not charge fees or costs in excess of... RELATED REQUIREMENTS ADMINISTRATIVE REQUIREMENTS General Provisions for Transactions § 162.925 Additional... transaction as a standard transaction, the health plan must do so. (2) A health plan may not delay or reject a...

  13. 40 CFR 144.85 - Do these additional requirements apply to me?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 24 2013-07-01 2013-07-01 false Do these additional requirements apply to me? 144.85 Section 144.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Vehicle Waste Disposal Wells § 144.85 Do these additional requirements apply to me? (a) Large-capacity...

  14. 40 CFR 144.85 - Do these additional requirements apply to me?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Do these additional requirements apply to me? 144.85 Section 144.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Vehicle Waste Disposal Wells § 144.85 Do these additional requirements apply to me? (a) Large-capacity...

  15. 40 CFR 144.85 - Do these additional requirements apply to me?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Do these additional requirements apply to me? 144.85 Section 144.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... of Class V Injection Wells § 144.85 Do these additional requirements apply to me? (a) Large-Capacity...

  16. 20 CFR 666.110 - May a Governor require additional indicators of performance?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false May a Governor require additional indicators... of Performance § 666.110 May a Governor require additional indicators of performance? Yes, Governors may develop additional indicators of performance for adults, youth and dislocated worker activities...

  17. 20 CFR 666.110 - May a Governor require additional indicators of performance?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false May a Governor require additional indicators... of Performance § 666.110 May a Governor require additional indicators of performance? Yes, Governors may develop additional indicators of performance for adults, youth and dislocated worker activities...

  18. 46 CFR 167.43-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Additional requirements for hybrid work vests. 167.43-25 Section 167.43-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS PUBLIC NAUTICAL SCHOOL SHIPS Work Vests § 167.43-25 Additional requirements for hybrid work vests. (a) In...

  19. 46 CFR 167.43-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Additional requirements for hybrid work vests. 167.43-25 Section 167.43-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS PUBLIC NAUTICAL SCHOOL SHIPS Work Vests § 167.43-25 Additional requirements for hybrid work vests. (a) In...

  20. 46 CFR 167.43-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Additional requirements for hybrid work vests. 167.43-25 Section 167.43-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS PUBLIC NAUTICAL SCHOOL SHIPS Work Vests § 167.43-25 Additional requirements for hybrid work vests. (a) In...

  1. 46 CFR 167.43-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Additional requirements for hybrid work vests. 167.43-25 Section 167.43-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS PUBLIC NAUTICAL SCHOOL SHIPS Work Vests § 167.43-25 Additional requirements for hybrid work vests. (a) In...

  2. 46 CFR 167.43-25 - Additional requirements for hybrid work vests.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Additional requirements for hybrid work vests. 167.43-25 Section 167.43-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS PUBLIC NAUTICAL SCHOOL SHIPS Work Vests § 167.43-25 Additional requirements for hybrid work vests. (a) In...

  3. 40 CFR 60.4176 - Additional requirements to provide heat input data.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Additional requirements to provide heat... Compliance Times for Coal-Fired Electric Steam Generating Units Monitoring and Reporting § 60.4176 Additional requirements to provide heat input data. The owner or operator of a Hg Budget unit that monitors and reports Hg...

  4. 29 CFR 502.44 - Additional information, if required.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Additional information, if required. 502.44 Section 502.44 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER SECTION 218 OF...

  5. 29 CFR 501.44 - Additional information, if required.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Additional information, if required. 501.44 Section 501.44 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER SECTION 218 OF...

  6. 33 CFR 154.1125 - Additional response plan requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Prince William Sound, Alaska § 154.1125 Additional response plan requirements. (a) The owner or operator of a TAPAA facility shall include the following information in the Prince William Sound appendix to... for personnel, including local residents and fishermen, from the following locations in Prince William...

  7. 25 CFR 304.4 - Standards and additional requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Standards and additional requirements. 304.4 Section 304.4 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO, PUEBLO, AND HOPI SILVER... in compliance with the standards set forth by the Indian Arts and Crafts Board, shall bear the...

  8. 20 CFR 416.805 - When additional evidence may be required.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false When additional evidence may be required. 416.805 Section 416.805 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Determination of Age § 416.805 When additional evidence may be...

  9. 34 CFR 379.45 - What are the additional reporting requirements?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION PROJECTS WITH INDUSTRY What Conditions Must Be Met by a Grantee? § 379.45 What are the additional reporting requirements? Each grantee must submit the data from its annual evaluation of project operations required under § 379.21(a)(5) no...

  10. 30 CFR 75.1103-10 - Fire suppression systems; additional requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... per minute, an additional cache of the materials specified in § 75.1103-9(a)(1), (2), and (3) shall be... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Fire suppression systems; additional requirements. 75.1103-10 Section 75.1103-10 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT...

  11. 40 CFR 141.624 - Additional requirements for consecutive systems.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Additional requirements for consecutive systems. 141.624 Section 141.624 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Stage 2 Disinfection...

  12. 40 CFR 141.624 - Additional requirements for consecutive systems.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 24 2013-07-01 2013-07-01 false Additional requirements for consecutive systems. 141.624 Section 141.624 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Stage 2 Disinfection...

  13. 40 CFR 141.624 - Additional requirements for consecutive systems.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 24 2012-07-01 2012-07-01 false Additional requirements for consecutive systems. 141.624 Section 141.624 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Stage 2 Disinfection...

  14. 40 CFR 141.624 - Additional requirements for consecutive systems.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 23 2014-07-01 2014-07-01 false Additional requirements for consecutive systems. 141.624 Section 141.624 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Stage 2 Disinfection...

  15. 21 CFR 70.25 - Labeling requirements for color additives (other than hair dyes).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Labeling requirements for color additives (other than hair dyes). 70.25 Section 70.25 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... color additives (other than hair dyes). (a) General labeling requirements. All color additives shall be...

  16. 21 CFR 70.25 - Labeling requirements for color additives (other than hair dyes).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Labeling requirements for color additives (other than hair dyes). 70.25 Section 70.25 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... color additives (other than hair dyes). (a) General labeling requirements. All color additives shall be...

  17. 21 CFR 70.25 - Labeling requirements for color additives (other than hair dyes).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Labeling requirements for color additives (other than hair dyes). 70.25 Section 70.25 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... color additives (other than hair dyes). (a) General labeling requirements. All color additives shall be...

  18. 40 CFR 80.1613 - Standards and other requirements for gasoline additive manufacturers and blenders.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... gasoline additive manufacturers and blenders. 80.1613 Section 80.1613 Protection of Environment... Gasoline Sulfur § 80.1613 Standards and other requirements for gasoline additive manufacturers and blenders. Gasoline additive manufacturers and blenders must meet the following requirements: (a) Gasoline additive...

  19. 41 CFR 60-2.17 - Additional required elements of affirmative action programs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... elements of affirmative action programs. 60-2.17 Section 60-2.17 Public Contracts and Property Management... Action Programs § 60-2.17 Additional required elements of affirmative action programs. In addition to the elements required by § 60-2.10 through § 60-2.16, an acceptable affirmative action program must include the...

  20. 41 CFR 60-2.17 - Additional required elements of affirmative action programs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... elements of affirmative action programs. 60-2.17 Section 60-2.17 Public Contracts and Property Management... Action Programs § 60-2.17 Additional required elements of affirmative action programs. In addition to the elements required by § 60-2.10 through § 60-2.16, an acceptable affirmative action program must include the...

  1. 41 CFR 60-2.17 - Additional required elements of affirmative action programs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... elements of affirmative action programs. 60-2.17 Section 60-2.17 Public Contracts and Property Management... Action Programs § 60-2.17 Additional required elements of affirmative action programs. In addition to the elements required by § 60-2.10 through § 60-2.16, an acceptable affirmative action program must include the...

  2. An analysis of thermal response factors and how to reduce their computational time requirement

    NASA Technical Reports Server (NTRS)

    Wiese, M. R.

    1982-01-01

    Te RESFAC2 version of the Thermal Response Factor Program (RESFAC) is the result of numerous modifications and additions to the original RESFAC. These modifications and additions have significantly reduced the program's computational time requirement. As a result of this work, the program is more efficient and its code is both readable and understandable. This report describes what a thermal response factor is; analyzes the original matrix algebra calculations and root finding techniques; presents a new root finding technique and streamlined matrix algebra; supplies ten validation cases and their results.

  3. 48 CFR 7.106 - Additional requirements for major systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... (b) In planning for the solicitation of a major system (see part 34) production contract, planners... REGULATION ACQUISITION PLANNING ACQUISITION PLANNING Acquisition Plans 7.106 Additional requirements for major systems. (a) In planning for the solicitation of a major system (see part 34) development contract...

  4. 48 CFR 7.106 - Additional requirements for major systems.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... (b) In planning for the solicitation of a major system (see part 34) production contract, planners... REGULATION ACQUISITION PLANNING ACQUISITION PLANNING Acquisition Plans 7.106 Additional requirements for major systems. (a) In planning for the solicitation of a major system (see part 34) development contract...

  5. 48 CFR 7.106 - Additional requirements for major systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... (b) In planning for the solicitation of a major system (see part 34) production contract, planners... REGULATION ACQUISITION PLANNING ACQUISITION PLANNING Acquisition Plans 7.106 Additional requirements for major systems. (a) In planning for the solicitation of a major system (see part 34) development contract...

  6. 48 CFR 7.106 - Additional requirements for major systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    .... (b) In planning for the solicitation of a major system (see part 34) production contract, planners... REGULATION ACQUISITION PLANNING ACQUISITION PLANNING Acquisition Plans 7.106 Additional requirements for major systems. (a) In planning for the solicitation of a major system (see part 34) development contract...

  7. 48 CFR 7.106 - Additional requirements for major systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .... (b) In planning for the solicitation of a major system (see part 34) production contract, planners... REGULATION ACQUISITION PLANNING ACQUISITION PLANNING Acquisition Plans 7.106 Additional requirements for major systems. (a) In planning for the solicitation of a major system (see part 34) development contract...

  8. 19 CFR 141.37 - Additional requirements for nonresident corporations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... corporations. 141.37 Section 141.37 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... Additional requirements for nonresident corporations. If a nonresident corporation has not qualified to... authority of the grantor designated to execute the power of attorney on behalf of the corporation. [T.D. 84...

  9. 19 CFR 141.37 - Additional requirements for nonresident corporations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... corporations. 141.37 Section 141.37 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... Additional requirements for nonresident corporations. If a nonresident corporation has not qualified to... authority of the grantor designated to execute the power of attorney on behalf of the corporation. [T.D. 84...

  10. 19 CFR 141.37 - Additional requirements for nonresident corporations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... corporations. 141.37 Section 141.37 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... Additional requirements for nonresident corporations. If a nonresident corporation has not qualified to... authority of the grantor designated to execute the power of attorney on behalf of the corporation. [T.D. 84...

  11. 19 CFR 141.37 - Additional requirements for nonresident corporations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... corporations. 141.37 Section 141.37 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... Additional requirements for nonresident corporations. If a nonresident corporation has not qualified to... authority of the grantor designated to execute the power of attorney on behalf of the corporation. [T.D. 84...

  12. 19 CFR 141.37 - Additional requirements for nonresident corporations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... corporations. 141.37 Section 141.37 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... Additional requirements for nonresident corporations. If a nonresident corporation has not qualified to... authority of the grantor designated to execute the power of attorney on behalf of the corporation. [T.D. 84...

  13. 36 CFR 1236.24 - What are the additional requirements for managing unstructured electronic records?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... requirements for managing unstructured electronic records? 1236.24 Section 1236.24 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT ELECTRONIC RECORDS MANAGEMENT Additional Requirements for Electronic Records § 1236.24 What are the additional requirements for managing...

  14. 36 CFR 1236.24 - What are the additional requirements for managing unstructured electronic records?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements for managing unstructured electronic records? 1236.24 Section 1236.24 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT ELECTRONIC RECORDS MANAGEMENT Additional Requirements for Electronic Records § 1236.24 What are the additional requirements for managing...

  15. 36 CFR 1236.24 - What are the additional requirements for managing unstructured electronic records?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requirements for managing unstructured electronic records? 1236.24 Section 1236.24 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT ELECTRONIC RECORDS MANAGEMENT Additional Requirements for Electronic Records § 1236.24 What are the additional requirements for managing...

  16. 36 CFR 1236.24 - What are the additional requirements for managing unstructured electronic records?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... requirements for managing unstructured electronic records? 1236.24 Section 1236.24 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT ELECTRONIC RECORDS MANAGEMENT Additional Requirements for Electronic Records § 1236.24 What are the additional requirements for managing...

  17. 33 CFR 105.295 - Additional requirements-Certain Dangerous Cargo (CDC) facilities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Dangerous Cargo (CDC) facilities. 105.295 Section 105.295 Navigation and Navigable Waters COAST GUARD... Requirements § 105.295 Additional requirements-Certain Dangerous Cargo (CDC) facilities. (a) At all MARSEC Levels, owners or operators of CDC facilities must ensure the implementation of the following security...

  18. 33 CFR 105.295 - Additional requirements-Certain Dangerous Cargo (CDC) facilities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Dangerous Cargo (CDC) facilities. 105.295 Section 105.295 Navigation and Navigable Waters COAST GUARD... Requirements § 105.295 Additional requirements-Certain Dangerous Cargo (CDC) facilities. (a) At all MARSEC Levels, owners or operators of CDC facilities must ensure the implementation of the following security...

  19. 33 CFR 105.295 - Additional requirements-Certain Dangerous Cargo (CDC) facilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Dangerous Cargo (CDC) facilities. 105.295 Section 105.295 Navigation and Navigable Waters COAST GUARD... Requirements § 105.295 Additional requirements-Certain Dangerous Cargo (CDC) facilities. (a) At all MARSEC Levels, owners or operators of CDC facilities must ensure the implementation of the following security...

  20. 33 CFR 105.295 - Additional requirements-Certain Dangerous Cargo (CDC) facilities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Dangerous Cargo (CDC) facilities. 105.295 Section 105.295 Navigation and Navigable Waters COAST GUARD... Requirements § 105.295 Additional requirements-Certain Dangerous Cargo (CDC) facilities. (a) At all MARSEC Levels, owners or operators of CDC facilities must ensure the implementation of the following security...

  1. 33 CFR 105.295 - Additional requirements-Certain Dangerous Cargo (CDC) facilities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Dangerous Cargo (CDC) facilities. 105.295 Section 105.295 Navigation and Navigable Waters COAST GUARD... Requirements § 105.295 Additional requirements-Certain Dangerous Cargo (CDC) facilities. (a) At all MARSEC Levels, owners or operators of CDC facilities must ensure the implementation of the following security...

  2. 49 CFR 173.24b - Additional general requirements for bulk packagings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... packagings. 173.24b Section 173.24b Transportation Other Regulations Relating to Transportation PIPELINE AND... SHIPPERS-GENERAL REQUIREMENTS FOR SHIPMENTS AND PACKAGINGS Preparation of Hazardous Materials for Transportation § 173.24b Additional general requirements for bulk packagings. (a) Outage and filling limits. (1...

  3. 30 CFR 75.151 - Tests for methane; qualified person; additional requirement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Tests for methane; qualified person; additional... Certified Persons § 75.151 Tests for methane; qualified person; additional requirement. Notwithstanding the... methane unless he demonstrates to the satisfaction of an authorized representative of the Secretary that...

  4. 30 CFR 75.151 - Tests for methane; qualified person; additional requirement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Tests for methane; qualified person; additional... Certified Persons § 75.151 Tests for methane; qualified person; additional requirement. Notwithstanding the... methane unless he demonstrates to the satisfaction of an authorized representative of the Secretary that...

  5. 76 FR 14562 - Federal Acquisition Regulation; Additional Requirements for Market Research

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-16

    ... circumstances and entry of new businesses, on- going market research is not a waste of manpower and taxpayers..., Sequence 1] RIN 9000-AL50 Federal Acquisition Regulation; Additional Requirements for Market Research..., Market Research, of the National Defense Authorization Act for Fiscal Year 2008. Section 826 requires the...

  6. 40 CFR 33.302 - Are there any additional contract administration requirements?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY PROGRAMS Good Faith Efforts § 33.302 Are there any additional contract... require its prime contractor to employ the six good faith efforts described in § 33.301 even if the prime... the subcontract for any reason, the recipient must require the prime contractor to employ the six good...

  7. Biomedical and Human Factors Requirements for a Manned Earth Orbiting Station

    NASA Technical Reports Server (NTRS)

    Benjamin, F.; Helvey, W. M.; Martell, C.; Peters, J.; Rosenthal, G.

    1964-01-01

    This report is the result of a study conducted by Republic Aviation Corporation in conjunction with Spacelabs, Inc.,in a team effort in which Republic Aviation Corporation was prime contractor. In order to determine the realistic engineering design requirements associated with the medical and human factors problems of a manned space station, an interdisciplinary team of personnel from the Research and Space Divisions was organized. This team included engineers, physicians, physiologists, psychologists, and physicists. Recognizing that the value of the study is dependent upon medical judgments as well as more quantifiable factors (such as design parameters) a group of highly qualified medical consultants participated in working sessions to determine which medical measurements are required to meet the objectives of the study. In addition, various Life Sciences personnel from NASA (Headquarters, Langley, MSC) participated in monthly review sessions. The organization, team members, consultants, and some of the part-time contributors are shown in Figure 1. This final report embodies contributions from all of these participants.

  8. 40 CFR 60.4176 - Additional requirements to provide heat input data.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 6 2011-07-01 2011-07-01 false Additional requirements to provide heat... requirements to provide heat input data. The owner or operator of a Hg Budget unit that monitors and reports Hg... monitor and report heat input rate at the unit level using the procedures set forth in part 75 of this...

  9. 15 CFR 291.6 - Additional requirements; Federal policies and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Additional requirements; Federal policies and procedures. 291.6 Section 291.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST...

  10. 15 CFR 291.6 - Additional requirements; Federal policies and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Additional requirements; Federal policies and procedures. 291.6 Section 291.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST...

  11. 15 CFR 291.6 - Additional requirements; Federal policies and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Additional requirements; Federal policies and procedures. 291.6 Section 291.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST...

  12. 15 CFR 291.6 - Additional requirements; Federal policies and procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Additional requirements; Federal policies and procedures. 291.6 Section 291.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST...

  13. 15 CFR 291.6 - Additional requirements; Federal policies and procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Additional requirements; Federal policies and procedures. 291.6 Section 291.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST...

  14. 5 CFR 890.1025 - Cases where additional fact-finding is not required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Sanctions Imposed Against Health Care Providers Permissive Debarments § 890.1025 Cases where additional fact..., suspension, restriction, or nonrenewal by a State licensing authority; (2) Debarment, exclusion, suspension... additional fact-finding proceeding is not required when: (a) Prior adjudication. The proposed debarment is...

  15. 12 CFR 987.8 - Additional requirements; notice of attachment for Book-entry consolidated obligations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... for Book-entry consolidated obligations. 987.8 Section 987.8 Banks and Banking FEDERAL HOUSING FINANCE BOARD OFFICE OF FINANCE BOOK-ENTRY PROCEDURE FOR CONSOLIDATED OBLIGATIONS § 987.8 Additional requirements; notice of attachment for Book-entry consolidated obligations. (a) Additional requirements. In any...

  16. 36 CFR § 1236.24 - What are the additional requirements for managing unstructured electronic records?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... requirements for managing unstructured electronic records? § 1236.24 Section § 1236.24 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT ELECTRONIC RECORDS MANAGEMENT Additional Requirements for Electronic Records § 1236.24 What are the additional requirements for...

  17. 40 CFR 80.521 - What are the standards and identification requirements for diesel fuel additives?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... identification requirements for diesel fuel additives? 80.521 Section 80.521 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES... requirements for diesel fuel additives? (a) Except as provided in paragraph (b) of this section, any diesel...

  18. 40 CFR 80.521 - What are the standards and identification requirements for diesel fuel additives?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... identification requirements for diesel fuel additives? 80.521 Section 80.521 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES... requirements for diesel fuel additives? (a) Except as provided in paragraph (b) of this section, any diesel...

  19. 40 CFR 80.521 - What are the standards and identification requirements for diesel fuel additives?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... identification requirements for diesel fuel additives? 80.521 Section 80.521 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES... requirements for diesel fuel additives? (a) Except as provided in paragraph (b) of this section, any diesel...

  20. 40 CFR 80.521 - What are the standards and identification requirements for diesel fuel additives?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... identification requirements for diesel fuel additives? 80.521 Section 80.521 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES... requirements for diesel fuel additives? (a) Except as provided in paragraph (b) of this section, any diesel...

  1. 40 CFR 80.521 - What are the standards and identification requirements for diesel fuel additives?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... identification requirements for diesel fuel additives? 80.521 Section 80.521 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES... requirements for diesel fuel additives? (a) Except as provided in paragraph (b) of this section, any diesel...

  2. 42 CFR 489.66 - Additional requirements of the surety bond.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Additional requirements of the surety bond. 489.66 Section 489.66 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond...

  3. 45 CFR 287.60 - Are there additional financial reporting and auditing requirements?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Are there additional financial reporting and... there additional financial reporting and auditing requirements? (a) The reporting of expenditures are... comply with all laws, regulations, and Departmental policies that govern submission of financial reports...

  4. 45 CFR 287.60 - Are there additional financial reporting and auditing requirements?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Are there additional financial reporting and... there additional financial reporting and auditing requirements? (a) The reporting of expenditures are... comply with all laws, regulations, and Departmental policies that govern submission of financial reports...

  5. 42 CFR 489.66 - Additional requirements of the surety bond.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Additional requirements of the surety bond. 489.66 Section 489.66 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... of this subpart, remains effective and the Surety remains liable for unpaid claims, civil money...

  6. 46 CFR 62.50-30 - Additional requirements for periodically unattended machinery plants.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 2 2014-10-01 2014-10-01 false Additional requirements for periodically unattended machinery plants. 62.50-30 Section 62.50-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING VITAL SYSTEM AUTOMATION Automated Self-propelled Vessel Manning § 62.50-30 Additional...

  7. 41 CFR 60-2.17 - Additional required elements of affirmative action programs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... elements of affirmative action programs. 60-2.17 Section 60-2.17 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 2-AFFIRMATIVE ACTION PROGRAMS Purpose and Contents of Affirmative Action Programs § 60-2.17 Additional required elements of affirmative action programs. In addition to the...

  8. 30 CFR 250.177 - What additional requirements may the Regional Supervisor order for a suspension?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What additional requirements may the Regional... Suspensions § 250.177 What additional requirements may the Regional Supervisor order for a suspension? If MMS grants or directs a suspension under paragraph § 250.172(b), the Regional Supervisor may require you to...

  9. 46 CFR 111.105-39 - Additional requirements for vessels carrying vehicles with fuel in their tanks.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Additional requirements for vessels carrying vehicles... SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Hazardous Locations § 111.105-39 Additional requirements for vessels carrying vehicles with fuel in their tanks. Each vessel...

  10. 46 CFR 111.105-39 - Additional requirements for vessels carrying vehicles with fuel in their tanks.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Additional requirements for vessels carrying vehicles... SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Hazardous Locations § 111.105-39 Additional requirements for vessels carrying vehicles with fuel in their tanks. Each vessel...

  11. 49 CFR 192.328 - Additional construction requirements for steel pipe using alternative maximum allowable operating...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Additional construction requirements for steel pipe using alternative maximum allowable operating pressure. 192.328 Section 192.328 Transportation... Lines and Mains § 192.328 Additional construction requirements for steel pipe using alternative maximum...

  12. 49 CFR 192.328 - Additional construction requirements for steel pipe using alternative maximum allowable operating...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Additional construction requirements for steel pipe using alternative maximum allowable operating pressure. 192.328 Section 192.328 Transportation... Lines and Mains § 192.328 Additional construction requirements for steel pipe using alternative maximum...

  13. 30 CFR 250.1166 - What additional reporting is required for developments in the Alaska OCS Region?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What additional reporting is required for... CONTINENTAL SHELF Oil and Gas Production Requirements Other Requirements § 250.1166 What additional reporting... correlative rights; and (3) Maximize ultimate recovery of oil and gas. (b) If your development is jointly...

  14. 30 CFR 250.1166 - What additional reporting is required for developments in the Alaska OCS Region?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What additional reporting is required for... CONTINENTAL SHELF Oil and Gas Production Requirements Other Requirements § 250.1166 What additional reporting... correlative rights; and (3) Maximize ultimate recovery of oil and gas. (b) If your development is jointly...

  15. 24 CFR 570.711 - State borrowers; additional requirements and application procedures.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false State borrowers; additional requirements and application procedures. 570.711 Section 570.711 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING...

  16. 24 CFR 570.711 - State borrowers; additional requirements and application procedures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true State borrowers; additional requirements and application procedures. 570.711 Section 570.711 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING...

  17. 24 CFR 570.711 - State borrowers; additional requirements and application procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false State borrowers; additional requirements and application procedures. 570.711 Section 570.711 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING...

  18. 42 CFR 403.306 - Additional requirements for State systems-mandatory approval.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Additional requirements for State systems-mandatory approval. 403.306 Section 403.306 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS Recognition of State...

  19. 49 CFR 218.105 - Additional operational requirements for hand-operated main track switches.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Additional operational requirements for hand... hand-operated main track switches. (a) Each railroad shall adopt and comply with an operating rule... the requirements of this section. (b) Designating switch position. The normal position of a hand...

  20. 46 CFR 111.105-39 - Additional requirements for vessels carrying vehicles with fuel in their tanks.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Additional requirements for vessels carrying vehicles with fuel in their tanks. 111.105-39 Section 111.105-39 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Hazardous Locations § 111.105-39 Additional requirements for vessels...

  1. 46 CFR 111.105-39 - Additional requirements for vessels carrying vehicles with fuel in their tanks.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Additional requirements for vessels carrying vehicles with fuel in their tanks. 111.105-39 Section 111.105-39 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Hazardous Locations § 111.105-39 Additional requirements for vessels...

  2. 46 CFR 62.50-20 - Additional requirements for minimally attended machinery plants.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) MARINE ENGINEERING VITAL SYSTEM AUTOMATION Automated Self-propelled Vessel Manning § 62.50-20 Additional... program must be functioning prior to the completion of the evaluation period for reduced manning required...

  3. 46 CFR 62.50-20 - Additional requirements for minimally attended machinery plants.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) MARINE ENGINEERING VITAL SYSTEM AUTOMATION Automated Self-propelled Vessel Manning § 62.50-20 Additional... program must be functioning prior to the completion of the evaluation period for reduced manning required...

  4. 46 CFR 62.50-20 - Additional requirements for minimally attended machinery plants.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) MARINE ENGINEERING VITAL SYSTEM AUTOMATION Automated Self-propelled Vessel Manning § 62.50-20 Additional... program must be functioning prior to the completion of the evaluation period for reduced manning required...

  5. 46 CFR 62.50-20 - Additional requirements for minimally attended machinery plants.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) MARINE ENGINEERING VITAL SYSTEM AUTOMATION Automated Self-propelled Vessel Manning § 62.50-20 Additional... program must be functioning prior to the completion of the evaluation period for reduced manning required...

  6. 10 CFR 73.60 - Additional requirements for physical protection at nonpower reactors.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... nonpower reactors licensed to operate at or above a power level of 2 megawatts thermal. [38 FR 35430, Dec... OF PLANTS AND MATERIALS Physical Protection Requirements at Fixed Sites § 73.60 Additional...

  7. 10 CFR 73.60 - Additional requirements for physical protection at nonpower reactors.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... nonpower reactors licensed to operate at or above a power level of 2 megawatts thermal. [38 FR 35430, Dec... OF PLANTS AND MATERIALS Physical Protection Requirements at Fixed Sites § 73.60 Additional...

  8. 10 CFR 73.60 - Additional requirements for physical protection at nonpower reactors.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... nonpower reactors licensed to operate at or above a power level of 2 megawatts thermal. [38 FR 35430, Dec... OF PLANTS AND MATERIALS Physical Protection Requirements at Fixed Sites § 73.60 Additional...

  9. 40 CFR 33.302 - Are there any additional contract administration requirements?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY PROGRAMS Good Faith Efforts § 33.302 Are there any additional contract... faith efforts described in § 33.301 if soliciting a replacement subcontractor. (d) A recipient must require its prime contractor to employ the six good faith efforts described in § 33.301 even if the prime...

  10. 40 CFR 33.302 - Are there any additional contract administration requirements?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY PROGRAMS Good Faith Efforts § 33.302 Are there any additional contract... faith efforts described in § 33.301 if soliciting a replacement subcontractor. (d) A recipient must require its prime contractor to employ the six good faith efforts described in § 33.301 even if the prime...

  11. 40 CFR 33.302 - Are there any additional contract administration requirements?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY PROGRAMS Good Faith Efforts § 33.302 Are there any additional contract... faith efforts described in § 33.301 if soliciting a replacement subcontractor. (d) A recipient must require its prime contractor to employ the six good faith efforts described in § 33.301 even if the prime...

  12. 40 CFR 33.302 - Are there any additional contract administration requirements?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY PROGRAMS Good Faith Efforts § 33.302 Are there any additional contract... faith efforts described in § 33.301 if soliciting a replacement subcontractor. (d) A recipient must require its prime contractor to employ the six good faith efforts described in § 33.301 even if the prime...

  13. 40 CFR 97.76 - Additional requirements to provide heat input data.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... heat input data. 97.76 Section 97.76 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Monitoring and Reporting § 97.76 Additional requirements to provide heat input data. The owner or operator of... a flow system shall also monitor and report heat input rate at the unit level using the procedures...

  14. 40 CFR 97.76 - Additional requirements to provide heat input data.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... heat input data. 97.76 Section 97.76 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Monitoring and Reporting § 97.76 Additional requirements to provide heat input data. The owner or operator of... a flow system shall also monitor and report heat input rate at the unit level using the procedures...

  15. 40 CFR 97.76 - Additional requirements to provide heat input data.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... heat input data. 97.76 Section 97.76 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Monitoring and Reporting § 97.76 Additional requirements to provide heat input data. The owner or operator of... a flow system shall also monitor and report heat input rate at the unit level using the procedures...

  16. 40 CFR 97.76 - Additional requirements to provide heat input data.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... heat input data. 97.76 Section 97.76 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Monitoring and Reporting § 97.76 Additional requirements to provide heat input data. The owner or operator of... a flow system shall also monitor and report heat input rate at the unit level using the procedures...

  17. 40 CFR 97.76 - Additional requirements to provide heat input data.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... heat input data. 97.76 Section 97.76 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Monitoring and Reporting § 97.76 Additional requirements to provide heat input data. The owner or operator of... a flow system shall also monitor and report heat input rate at the unit level using the procedures...

  18. 13 CFR 120.470 - What are SBA's additional requirements for SBLCs?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... requirements for SBLCs? 120.470 Section 120.470 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Lenders Small Business Lending Companies (sblc) § 120.470 What are SBA's additional... follow. (a) Lending. An SBLC may only make: (1) Loans under section 7(a) (except section 7(a)(13) of the...

  19. 13 CFR 120.470 - What are SBA's additional requirements for SBLCs?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... requirements for SBLCs? 120.470 Section 120.470 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Lenders Small Business Lending Companies (sblc) § 120.470 What are SBA's additional... follow. (a) Lending. An SBLC may only make: (1) Loans under section 7(a) (except section 7(a)(13) of the...

  20. 13 CFR 120.470 - What are SBA's additional requirements for SBLCs?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... requirements for SBLCs? 120.470 Section 120.470 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Lenders Small Business Lending Companies (sblc) § 120.470 What are SBA's additional... follow. (a) Lending. An SBLC may only make: (1) Loans under section 7(a) (except section 7(a)(13) of the...

  1. 13 CFR 120.470 - What are SBA's additional requirements for SBLCs?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... requirements for SBLCs? 120.470 Section 120.470 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Lenders Small Business Lending Companies (sblc) § 120.470 What are SBA's additional... follow. (a) Lending. An SBLC may only make: (1) Loans under section 7(a) (except section 7(a)(13) of the...

  2. 13 CFR 120.470 - What are SBA's additional requirements for SBLCs?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... requirements for SBLCs? 120.470 Section 120.470 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Lenders Small Business Lending Companies (sblc) § 120.470 What are SBA's additional... follow. (a) Lending. An SBLC may only make: (1) Loans under section 7(a) (except section 7(a)(13) of the...

  3. 43 CFR 3515.23 - May BLM require me to submit additional information?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... require me to submit additional information? Yes. You must be willing to provide geologic and economic data we need to determine the fair market value of your preference right or lease to be relinquished. ...

  4. Studies on a complex mechanism for the activation of plasminogen by kaolin and by chloroform: the participation of Hageman factor and additional cofactors

    PubMed Central

    Ogston, Derek; Ogston, C. Marie; Ratnoff, Oscar D.; Forbes, Charles D.

    1969-01-01

    As demonstrated by others, fibrinolytic activity was generated in diluted, acidified normal plasma exposed to kaolin, a process requiring Hageman factor (Factor XII). Generation was impaired by adsorbing plasma with glass or similar agents under conditions which did not deplete its content of Hageman factor or plasminogen. The defect could be repaired by addition of a noneuglobulin fraction of plasma or an agent or agents eluted from diatomaceous earth which had been exposed to normal plasma. The restorative agent, tentatively called Hageman factor-cofactor, was partially purified by chromatography and had an apparent molecular weight of approximately 165,000. It could be distinguished from plasma thromboplastin antecedent (Factor XI) and plasma kallikrein, other substrates of Hageman factor, and from the streptokinase-activated pro-activator of plasminogen. Evidence is presented that an additional component may be needed for the generation of fibrinolytic activity in mixtures containing Hageman factor, HF-cofactor, and plasminogen. The long-recognized generation of plasmin activity in chloroform-treated euglobulin fractions of plasma was found to be dependent upon the presence of Hageman factor. Whether chloroform activation of plasminogen requires Hageman factor-cofactor was not determined, but glass-adsorbed plasma, containing Hageman factor and plasminogen, did not generate appreciable fibrinolytic or caseinolytic activity. These studies emphasize the complex nature of the mechanisms which lead to the generation of plasmin in human plasma. PMID:4241814

  5. 45 CFR 96.86 - Exemption from requirement for additional outreach and intake services.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... and intake services. 96.86 Section 96.86 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... requirement for additional outreach and intake services. The requirement in section 2605(b)(15) of Public Law 97-35 (42 U.S.C. 8624(b)(15)), as amended by section 704(a)(4) of the Augustus F. Hawkins Human...

  6. 24 CFR 982.629 - Homeownership option: Additional PHA requirements for family search and purchase.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... PHA requirements for family search and purchase. 982.629 Section 982.629 Housing and Urban Development...: Additional PHA requirements for family search and purchase. (a) The PHA may establish the maximum time for a family to locate a home, and to purchase the home. (b) The PHA may require periodic family reports on the...

  7. 24 CFR 982.629 - Homeownership option: Additional PHA requirements for family search and purchase.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... PHA requirements for family search and purchase. 982.629 Section 982.629 Housing and Urban Development...: Additional PHA requirements for family search and purchase. (a) The PHA may establish the maximum time for a family to locate a home, and to purchase the home. (b) The PHA may require periodic family reports on the...

  8. 24 CFR 982.629 - Homeownership option: Additional PHA requirements for family search and purchase.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... PHA requirements for family search and purchase. 982.629 Section 982.629 Housing and Urban Development...: Additional PHA requirements for family search and purchase. (a) The PHA may establish the maximum time for a family to locate a home, and to purchase the home. (b) The PHA may require periodic family reports on the...

  9. 24 CFR 982.629 - Homeownership option: Additional PHA requirements for family search and purchase.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... PHA requirements for family search and purchase. 982.629 Section 982.629 Housing and Urban Development...: Additional PHA requirements for family search and purchase. (a) The PHA may establish the maximum time for a family to locate a home, and to purchase the home. (b) The PHA may require periodic family reports on the...

  10. 24 CFR 982.629 - Homeownership option: Additional PHA requirements for family search and purchase.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... PHA requirements for family search and purchase. 982.629 Section 982.629 Housing and Urban Development...: Additional PHA requirements for family search and purchase. (a) The PHA may establish the maximum time for a family to locate a home, and to purchase the home. (b) The PHA may require periodic family reports on the...

  11. Additive Manufacturing in Production: A Study Case Applying Technical Requirements

    NASA Astrophysics Data System (ADS)

    Ituarte, Iñigo Flores; Coatanea, Eric; Salmi, Mika; Tuomi, Jukka; Partanen, Jouni

    Additive manufacturing (AM) is expanding the manufacturing capabilities. However, quality of AM produced parts is dependent on a number of machine, geometry and process parameters. The variability of these parameters affects the manufacturing drastically and therefore standardized processes and harmonized methodologies need to be developed to characterize the technology for end use applications and enable the technology for manufacturing. This research proposes a composite methodology integrating Taguchi Design of Experiments, multi-objective optimization and statistical process control, to optimize the manufacturing process and fulfil multiple requirements imposed to an arbitrary geometry. The proposed methodology aims to characterize AM technology depending upon manufacturing process variables as well as to perform a comparative assessment of three AM technologies (Selective Laser Sintering, Laser Stereolithography and Polyjet). Results indicate that only one machine, laser-based Stereolithography, was feasible to fulfil simultaneously macro and micro level geometrical requirements but mechanical properties were not at required level. Future research will study a single AM system at the time to characterize AM machine technical capabilities and stimulate pre-normative initiatives of the technology for end use applications.

  12. Factors which Limit the Value of Additional Redundancy in Human Rated Launch Vehicle Systems

    NASA Technical Reports Server (NTRS)

    Anderson, Joel M.; Stott, James E.; Ring, Robert W.; Hatfield, Spencer; Kaltz, Gregory M.

    2008-01-01

    The National Aeronautics and Space Administration (NASA) has embarked on an ambitious program to return humans to the moon and beyond. As NASA moves forward in the development and design of new launch vehicles for future space exploration, it must fully consider the implications that rule-based requirements of redundancy or fault tolerance have on system reliability/risk. These considerations include common cause failure, increased system complexity, combined serial and parallel configurations, and the impact of design features implemented to control premature activation. These factors and others must be considered in trade studies to support design decisions that balance safety, reliability, performance and system complexity to achieve a relatively simple, operable system that provides the safest and most reliable system within the specified performance requirements. This paper describes conditions under which additional functional redundancy can impede improved system reliability. Examples from current NASA programs including the Ares I Upper Stage will be shown.

  13. 15 CFR 713.4 - Advance declaration requirements for additionally planned production, processing, or consumption...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 2 CHEMICALS § 713.4 Advance declaration requirements for additionally planned production... additionally planned production, processing, or consumption of Schedule 2 chemicals. 713.4 Section 713.4...

  14. 15 CFR 713.4 - Advance declaration requirements for additionally planned production, processing, or consumption...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 2 CHEMICALS § 713.4 Advance declaration requirements for additionally planned production... additionally planned production, processing, or consumption of Schedule 2 chemicals. 713.4 Section 713.4...

  15. 22 CFR 124.9 - Additional clauses required only in manufacturing license agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... manufacturing license agreements. 124.9 Section 124.9 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL... Additional clauses required only in manufacturing license agreements. (a) Clauses for all manufacturing license agreements. The following clauses must be included only in manufacturing license agreements: (1...

  16. 75 FR 9114 - Defense Federal Acquisition Regulation Supplement; Additional Requirements Applicable to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    ... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 217 Defense Federal Acquisition Regulation Supplement; Additional Requirements Applicable to Multiyear Contracts (DFARS Case 2008-D023) AGENCY: Defense Acquisition Regulations System. Department of Defense (DoD). ACTION: Interim rule...

  17. 10 CFR 35.647 - Additional technical requirements for mobile remote afterloader units.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Additional technical requirements for mobile remote afterloader units. 35.647 Section 35.647 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL Photon Emitting Remote Afterloader Units, Teletherapy Units, and Gamma Stereotactic Radiosurgery...

  18. 10 CFR 35.647 - Additional technical requirements for mobile remote afterloader units.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Additional technical requirements for mobile remote afterloader units. 35.647 Section 35.647 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL Photon Emitting Remote Afterloader Units, Teletherapy Units, and Gamma Stereotactic Radiosurgery...

  19. 10 CFR 35.647 - Additional technical requirements for mobile remote afterloader units.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Additional technical requirements for mobile remote afterloader units. 35.647 Section 35.647 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL Photon Emitting Remote Afterloader Units, Teletherapy Units, and Gamma Stereotactic Radiosurgery...

  20. 10 CFR 35.647 - Additional technical requirements for mobile remote afterloader units.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Additional technical requirements for mobile remote afterloader units. 35.647 Section 35.647 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL Photon Emitting Remote Afterloader Units, Teletherapy Units, and Gamma Stereotactic Radiosurgery...

  1. 49 CFR 218.107 - Additional operational requirements for hand-operated crossover switches.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...-operated crossover switches. 218.107 Section 218.107 Transportation Other Regulations Relating to... PRACTICES Handling Equipment, Switches, and Fixed Derails § 218.107 Additional operational requirements for hand-operated crossover switches. (a) Each railroad shall adopt and comply with an operating rule which...

  2. 49 CFR 218.107 - Additional operational requirements for hand-operated crossover switches.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-operated crossover switches. 218.107 Section 218.107 Transportation Other Regulations Relating to... PRACTICES Handling Equipment, Switches, and Fixed Derails § 218.107 Additional operational requirements for hand-operated crossover switches. (a) Each railroad shall adopt and comply with an operating rule which...

  3. 49 CFR 218.107 - Additional operational requirements for hand-operated crossover switches.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...-operated crossover switches. 218.107 Section 218.107 Transportation Other Regulations Relating to... PRACTICES Handling Equipment, Switches, and Fixed Derails § 218.107 Additional operational requirements for hand-operated crossover switches. (a) Each railroad shall adopt and comply with an operating rule which...

  4. 49 CFR 218.107 - Additional operational requirements for hand-operated crossover switches.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...-operated crossover switches. 218.107 Section 218.107 Transportation Other Regulations Relating to... PRACTICES Handling Equipment, Switches, and Fixed Derails § 218.107 Additional operational requirements for hand-operated crossover switches. (a) Each railroad shall adopt and comply with an operating rule which...

  5. 49 CFR 218.107 - Additional operational requirements for hand-operated crossover switches.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...-operated crossover switches. 218.107 Section 218.107 Transportation Other Regulations Relating to... PRACTICES Handling Equipment, Switches, and Fixed Derails § 218.107 Additional operational requirements for hand-operated crossover switches. (a) Each railroad shall adopt and comply with an operating rule which...

  6. 29 CFR 1910.126 - Additional requirements for special dipping and coating operations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 5 2012-07-01 2012-07-01 false Additional requirements for special dipping and coating operations. 1910.126 Section 1910.126 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS Hazardous Materials...

  7. 26 CFR 1.852-7 - Additional information required in returns of shareholders.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Regulated Investment Companies and Real Estate Investment Trusts § 1.852-7 Additional information required in returns of shareholders. Any person who fails or refuses to comply with the demand of a regulated investment company for the written statements...

  8. 26 CFR 1.852-7 - Additional information required in returns of shareholders.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Regulated Investment Companies and Real Estate Investment Trusts § 1.852-7 Additional information required in returns of shareholders. Any person who fails or refuses to comply with the demand of a regulated investment company for the written statements...

  9. 26 CFR 1.852-7 - Additional information required in returns of shareholders.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Regulated Investment Companies and Real Estate Investment Trusts § 1.852-7 Additional information required in returns of shareholders. Any person who fails or refuses to comply with the demand of a regulated investment company for the written statements...

  10. 26 CFR 1.852-7 - Additional information required in returns of shareholders.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Regulated Investment Companies and Real Estate Investment Trusts § 1.852-7 Additional information required in returns of shareholders. Any person who fails or refuses to comply with the demand of a regulated investment company for the written statements...

  11. Testicular differentiation factor SF-1 is required for human spleen development

    PubMed Central

    Zangen, David; Kaufman, Yotam; Banne, Ehud; Weinberg-Shukron, Ariella; Abulibdeh, Abdulsalam; Garfinkel, Benjamin P.; Dweik, Dima; Kanaan, Moein; Camats, Núria; Flück, Christa; Renbaum, Paul; Levy-Lahad, Ephrat

    2014-01-01

    The transcription factor steroidogenic factor 1 (SF-1; also known as NR5A1) is a crucial mediator of both steroidogenic and nonsteroidogenic tissue differentiation. Mutations within SF1 underlie different disorders of sexual development (DSD), including sex reversal, spermatogenic failure, ovarian insufficiency, and adrenocortical deficiency. Here, we identified a recessive mutation within SF1 that resulted in a substitution of arginine to glutamine at codon 103 (R103Q) in a child with both severe 46,XY-DSD and asplenia. The R103Q mutation decreased SF-1 transactivation of TLX1, a transcription factor that has been shown to be essential for murine spleen development. Additionally, the SF1 R103Q mutation impaired activation of steroidogenic genes, without affecting synergistic SF-1 and sex-determining region Y (SRY) coactivation of the testis development gene SOX9. Together, our data provide evidence that SF-1 is required for spleen development in humans via transactivation of TLX1 and that mutations that only impair steroidogenesis, without altering the SF1/SRY transactivation of SOX9, can lead to 46,XY-DSD. PMID:24905461

  12. 30 CFR 250.449 - What additional BOP testing requirements must I meet?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Blowout Preventer (bop) System Requirements § 250.449 What additional BOP... water to conduct this test. You may use drilling fluids to conduct subsequent tests of a subsea BOP...

  13. 30 CFR 250.449 - What additional BOP testing requirements must I meet?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Blowout Preventer (bop) System Requirements § 250.449 What additional BOP... water to conduct this test. You may use drilling fluids to conduct subsequent tests of a subsea BOP...

  14. 30 CFR 250.449 - What additional BOP testing requirements must I meet?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Blowout Preventer (bop) System Requirements § 250.449 What additional BOP... water to conduct this test. You may use drilling fluids to conduct subsequent tests of a subsea BOP...

  15. 47 CFR 5.311 - Additional requirements related to safety of the public.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... safety of the public. In addition to the notification requirements of § 5.309, for experiments that may... bands and geographic area as the planned experiment and, as appropriate, their end users; (b) Rapid identification, and elimination, of any harm the experiment may cause; and (c) Identifying an alternate means for...

  16. 47 CFR 5.311 - Additional requirements related to safety of the public.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... safety of the public. In addition to the notification requirements of § 5.309, for experiments that may... bands and geographic area as the planned experiment and, as appropriate, their end users; (b) Rapid identification, and elimination, of any harm the experiment may cause; and (c) Identifying an alternate means for...

  17. 21 CFR 70.25 - Labeling requirements for color additives (other than hair dyes).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... suitable for coloring the human body, shall state: (1) The name of the straight color or the name of each... AND HUMAN SERVICES GENERAL COLOR ADDITIVES Packaging and Labeling § 70.25 Labeling requirements for...

  18. 21 CFR 70.25 - Labeling requirements for color additives (other than hair dyes).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... suitable for coloring the human body, shall state: (1) The name of the straight color or the name of each... AND HUMAN SERVICES GENERAL COLOR ADDITIVES Packaging and Labeling § 70.25 Labeling requirements for...

  19. Co-factors Required for TLR7- and TLR9- dependent Innate Immune Responses

    PubMed Central

    Chiang, Chih-yuan; Engel, Alex; Opaluch, Amanda M.; Ramos, Irene; Maestre, Ana M.; Secundino, Ismael; De Jesus, Paul D.; Nguyen, Quy T.; Welch, Genevieve; Bonamy, Ghislain M.C.; Miraglia, Loren J.; Orth, Anthony P.; Nizet, Victor; Fernandez-Sesma, Ana; Zhou, Yingyao; Barton, Gregory M.; Chanda, Sumit K.

    2012-01-01

    SUMMARY Pathogens commonly utilize endocytic pathways to gain cellular access. The endosomal pattern recognition receptors TLR7 and TLR9 detect pathogen-encoded nucleic acids to initiate MyD88-dependent pro-inflammatory responses to microbial infection. Using genome-wide RNAi screening and integrative systems-based analysis we identify 190 co-factors required for TLR7- and TLR9-directed signaling responses. A set of co-factors were cross-profiled for their activities downstream of several immunoreceptors, and then functionally mapped based on the known architecture of NF-κB signaling pathways. Protein complexes and pathways involved in ubiquitin-protein ligase activities, sphingolipid metabolism, chromatin modifications, and ancient stress responses were found to modulate innate recognition of endosomal nucleic acids. Additionally, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) was characterized as necessary for ubiquitin-dependent TLR9 targeting to the endolysosome. Proteins and pathways identified here should prove useful in delineating strategies to manipulate innate responses for treatment of autoimmune disorders and microbial infection. PMID:22423970

  20. 30 CFR 250.449 - What additional BOP testing requirements must I meet?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...? You must meet the following additional BOP testing requirements: (a) Use water to test a surface BOP system; (b) Stump test a subsea BOP system before installation. You must use water to conduct this test. You may use drilling fluids to conduct subsequent tests of a subsea BOP system; (c) Alternate tests...

  1. 25 CFR 1000.396 - Does a Tribe/Consortium have additional ongoing requirements to maintain minimum standards for...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false Does a Tribe/Consortium have additional ongoing requirements to maintain minimum standards for Tribe/Consortium management systems? 1000.396 Section 1000.396... Miscellaneous Provisions § 1000.396 Does a Tribe/Consortium have additional ongoing requirements to maintain...

  2. 42 CFR 482.104 - Condition of participation: Additional requirements for kidney transplant centers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... for kidney transplant centers. 482.104 Section 482.104 Public Health CENTERS FOR MEDICARE & MEDICAID....104 Condition of participation: Additional requirements for kidney transplant centers. (a) Standard: End stage renal disease (ESRD) services. Kidney transplant centers must directly furnish...

  3. 42 CFR 482.104 - Condition of participation: Additional requirements for kidney transplant centers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... for kidney transplant centers. 482.104 Section 482.104 Public Health CENTERS FOR MEDICARE & MEDICAID....104 Condition of participation: Additional requirements for kidney transplant centers. (a) Standard: End stage renal disease (ESRD) services. Kidney transplant centers must directly furnish...

  4. 76 FR 82308 - Guidance for Industry: Current Good Tissue Practice and Additional Requirements for Manufacturers...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-30

    ... Cells, Tissues, and Cellular and Tissue-Based Products; Availability AGENCY: Food and Drug... Requirements for Manufacturers of Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps)'' dated... Tissue Practice (CGTP) and Additional Requirements for Manufacturers of Human Cells, Tissues, and...

  5. 15 CFR 714.3 - Advance declaration requirements for additionally planned production of Schedule 3 chemicals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS § 714.3 Advance declaration requirements for additionally planned production of Schedule 3 chemicals. (a) Declaration... additionally planned production of Schedule 3 chemicals. 714.3 Section 714.3 Commerce and Foreign Trade...

  6. 14 CFR 91.1045 - Additional equipment requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... specified in that section. (5) Airborne weather radar as required by § 121.357 of this chapter, as... section, either: (i) Airborne thunderstorm detection equipment as required by § 135.173 of this chapter; or (ii) Airborne weather radar as required by § 135.175 of this chapter. ...

  7. 34 CFR 477.22 - What additional factors does the Secretary consider?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE PROGRAM ANALYSIS ASSISTANCE AND POLICY STUDIES PROGRAM How Does the Secretary Make an Award? § 477.22 What additional factors does the...

  8. 34 CFR 477.22 - What additional factors does the Secretary consider?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE PROGRAM ANALYSIS ASSISTANCE AND POLICY STUDIES PROGRAM How Does the Secretary Make an Award? § 477.22 What additional factors does the...

  9. 5 CFR 890.1027 - Cases where an additional fact-finding proceeding is required.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... proceeding is required. 890.1027 Section 890.1027 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Administrative Sanctions Imposed Against Health Care Providers Permissive Debarments § 890.1027 Cases where an additional...

  10. 32 CFR Appendix A to 32 Cfr Part 65 - Additional Reporting Requirements

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Requirements Table 1—Data Elements From DoD Instruction 1336.5 and DoD Instruction 7730.54 Relevant to This Part Field Data element name Description References 947-954 d. Initial Entry Training End Calendar Date... title 10, U.S.C See DoD Instruction 1336.5 for additional data elements. 955-971 Active Duty Loan...

  11. 78 FR 21159 - Additional Requirements for Special Dipping and Coating Operations (Dip Tanks); Extension of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-09

    ...] Additional Requirements for Special Dipping and Coating Operations (Dip Tanks); Extension of the Office of Management and Budget's Approval of the Information Collection (Paperwork) Requirement AGENCY: Occupational... requirement specified in its Standard on Dipping and Coating Operations (Dip Tanks) (29 CFR 1910.126(g)(4...

  12. 34 CFR 400.9 - What additional requirements govern the Vocational and Applied Technology Education Programs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Applied Technology Education Programs? 400.9 Section 400.9 Education Regulations of the Offices of the... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.9 What additional requirements govern the Vocational and Applied Technology Education Programs? In addition to the Act, applicable...

  13. 34 CFR 400.9 - What additional requirements govern the Vocational and Applied Technology Education Programs?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Applied Technology Education Programs? 400.9 Section 400.9 Education Regulations of the Offices of the... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.9 What additional requirements govern the Vocational and Applied Technology Education Programs? In addition to the Act, applicable...

  14. 34 CFR 400.9 - What additional requirements govern the Vocational and Applied Technology Education Programs?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Applied Technology Education Programs? 400.9 Section 400.9 Education Regulations of the Offices of the... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.9 What additional requirements govern the Vocational and Applied Technology Education Programs? In addition to the Act, applicable...

  15. 34 CFR 400.9 - What additional requirements govern the Vocational and Applied Technology Education Programs?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Applied Technology Education Programs? 400.9 Section 400.9 Education Regulations of the Offices of the... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.9 What additional requirements govern the Vocational and Applied Technology Education Programs? In addition to the Act, applicable...

  16. 34 CFR 400.9 - What additional requirements govern the Vocational and Applied Technology Education Programs?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Applied Technology Education Programs? 400.9 Section 400.9 Education Regulations of the Offices of the... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.9 What additional requirements govern the Vocational and Applied Technology Education Programs? In addition to the Act, applicable...

  17. 47 CFR 54.202 - Additional requirements for Commission designation of eligible telecommunications carriers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 3 2014-10-01 2014-10-01 false Additional requirements for Commission designation of eligible telecommunications carriers. 54.202 Section 54.202 Telecommunication FEDERAL... telecommunications carriers. (a) In order to be designated an eligible telecommunications carrier under section 214(e...

  18. 47 CFR 54.202 - Additional requirements for Commission designation of eligible telecommunications carriers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 3 2012-10-01 2012-10-01 false Additional requirements for Commission designation of eligible telecommunications carriers. 54.202 Section 54.202 Telecommunication FEDERAL... telecommunications carriers. (a) In order to be designated an eligible telecommunications carrier under section 214(e...

  19. 47 CFR 54.202 - Additional requirements for Commission designation of eligible telecommunications carriers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 3 2013-10-01 2013-10-01 false Additional requirements for Commission designation of eligible telecommunications carriers. 54.202 Section 54.202 Telecommunication FEDERAL... telecommunications carriers. (a) In order to be designated an eligible telecommunications carrier under section 214(e...

  20. 30 CFR 77.102 - Tests for methane; oxygen deficiency; qualified person, additional requirement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Tests for methane; oxygen deficiency; qualified... methane; oxygen deficiency; qualified person, additional requirement. Notwithstanding the provisions of... and oxygen deficiency unless he has demonstrated to the satisfaction of an authorized representative...

  1. 30 CFR 77.102 - Tests for methane; oxygen deficiency; qualified person, additional requirement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Tests for methane; oxygen deficiency; qualified... methane; oxygen deficiency; qualified person, additional requirement. Notwithstanding the provisions of... and oxygen deficiency unless he has demonstrated to the satisfaction of an authorized representative...

  2. 30 CFR 77.102 - Tests for methane; oxygen deficiency; qualified person, additional requirement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Tests for methane; oxygen deficiency; qualified... methane; oxygen deficiency; qualified person, additional requirement. Notwithstanding the provisions of... and oxygen deficiency unless he has demonstrated to the satisfaction of an authorized representative...

  3. 30 CFR 77.102 - Tests for methane; oxygen deficiency; qualified person, additional requirement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Tests for methane; oxygen deficiency; qualified... methane; oxygen deficiency; qualified person, additional requirement. Notwithstanding the provisions of... and oxygen deficiency unless he has demonstrated to the satisfaction of an authorized representative...

  4. 49 CFR 218.105 - Additional operational requirements for hand-operated main track switches.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...-operated main track switches. 218.105 Section 218.105 Transportation Other Regulations Relating to... PRACTICES Handling Equipment, Switches, and Fixed Derails § 218.105 Additional operational requirements for hand-operated main track switches. (a) Each railroad shall adopt and comply with an operating rule...

  5. 49 CFR 218.105 - Additional operational requirements for hand-operated main track switches.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...-operated main track switches. 218.105 Section 218.105 Transportation Other Regulations Relating to... PRACTICES Handling Equipment, Switches, and Fixed Derails § 218.105 Additional operational requirements for hand-operated main track switches. (a) Each railroad shall adopt and comply with an operating rule...

  6. 49 CFR 218.105 - Additional operational requirements for hand-operated main track switches.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...-operated main track switches. 218.105 Section 218.105 Transportation Other Regulations Relating to... PRACTICES Handling Equipment, Switches, and Fixed Derails § 218.105 Additional operational requirements for hand-operated main track switches. (a) Each railroad shall adopt and comply with an operating rule...

  7. 49 CFR 218.105 - Additional operational requirements for hand-operated main track switches.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...-operated main track switches. 218.105 Section 218.105 Transportation Other Regulations Relating to... PRACTICES Handling Equipment, Switches, and Fixed Derails § 218.105 Additional operational requirements for hand-operated main track switches. (a) Each railroad shall adopt and comply with an operating rule...

  8. 10 CFR 431.174 - Additional requirements applicable to Voluntary Independent Certification Program participants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Provisions for Commercial Heating, Ventilating, Air-Conditioning and Water Heating Products § 431.174 Additional... commercial HVAC and WH product, as described in § 431.176, and that complies with all requirements imposed by...

  9. Methotrexate for uveitis associated with juvenile idiopathic arthritis: value and requirement for additional anti-inflammatory medication.

    PubMed

    Heiligenhaus, A; Mingels, A; Heinz, C; Ganser, G

    2007-01-01

    To study the value of methotrexate (MTX) and the requirement for additional anti-inflammatory drugs for the treatment of severe chronic iridocyclitis associated with juvenile idiopathic arthritis (JIA). Institutional study of 35 consecutive patients with JIA started on MTX as the single systemic immunosuppressive drug for the treatment of associated iridocyclitis. The clinical epidemiologic data, course of visual acuity (VA), development of complications, and the need for additional anti-inflammatory drugs were analyzed. Mean follow-up with MTX treatment was 27.6 months. Uveitic complications were present in 31 patients before MTX treatment. With MTX, quiescence of uveitis was obtained with (n=21) or without (n=4) additional topical steroids. Additional systemic immunosuppressive drugs were required in another 7 patients: cyclosporine A (n=4), azathioprine (n=1), infliximab (n=1), or etanercept (n=1). Three patients had active uveitis at the end of the follow-up period. During MTX therapy, uveitis first developed in the unaffected fellow eyes in 2 patients, and secondary glaucoma or ocular hypertension occurred in 7 patients. The VA deteriorated in 6, improved in 13, and was stable in the remaining eyes. The data suggest that MTX is very effective in controlling inflammation of uveitis in patients with JIA. However, additional topical steroids or systemic immunosuppressive drugs are often required.

  10. 30 CFR 77.102 - Tests for methane; oxygen deficiency; qualified person, additional requirement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Tests for methane; oxygen deficiency; qualified... methane; oxygen deficiency; qualified person, additional requirement. Notwithstanding the provisions of § 77.101, on and after December 30, 1971, no person shall be a qualified person for testing for methane...

  11. 18 CFR 33.4 - Additional information requirements for applications involving vertical competitive impacts.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Additional information requirements for applications involving vertical competitive impacts. 33.4 Section 33.4 Conservation of Power... electricity products (i.e., downstream relevant products) in the same geographic markets or that the extent of...

  12. The Modeling of Factors That Influence Coast Guard Manpower Requirements

    DTIC Science & Technology

    2014-12-01

    applications, and common data warehouses needed to fully develop an effective and efficient manpower requirements engineering and management program. The... manpower requirements determination ensures a ready force, and safe and effective mission execution. Shortage or excess of manpower is the catalyst...FACTORS THAT INFLUENCE COAST GUARD MANPOWER REQUIREMENTS by Kara M. Lavin December 2014 Thesis Advisor: Ronald E. Giachetti Co-Advisor

  13. Translational Control of Hemoglobin Synthesis by an Initiation Factor Required for Recycling of Ribosomes and for their Binding to Messenger RNA

    PubMed Central

    Kaempfer, Raymond; Kaufman, Jennifer

    1972-01-01

    The continued recycling of ribosomes during protein synthesis in rabbit reticulocyte lysates at 37° requires an initiation factor whose activity is rapidly lost in the absence of added heme. Partially purified factor (i) fully maintains the polysomes; (ii) inhibits the association of 40S and 60S ribosomal subunits into single ribosomes; (iii) promotes the quantitative entry of added 60S subunits into polysomes; (iv) allows the accumulation of ribosomal subunits, instead of single ribosomes, when initiation is blocked with aurin tricarboxylate; and (v) is absolutely required for the binding of globin messenger RNA to ribosomes. These properties suggest that this mammalian initiation factor functions analogously to bacterial IF-3. In addition, the translational control of globin synthesis by heme is exerted, directly or indirectly, through this factor. PMID:4508325

  14. 75 FR 34277 - Federal Acquisition Regulation; FAR Case 2008-007, Additional Requirements for Market Research

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ...The Civilian Agency Acquisition Council and the Defense Acquisition Regulations Council (Councils) have agreed on an interim rule amending the Federal Acquisition Regulation (FAR) to implement Section 826 of the National Defense Authorization Act for Fiscal Year 2008 (FY08 NDAA). Section 826 established additional requirements in subsection (c) of 10 U.S.C. 2377. As a matter of policy, these requirements are extended to all executive agencies. Specifically, the head of the agency must conduct market research before issuing an indefinite-delivery indefinite-quantity (ID/IQ) task or delivery order for a noncommercial item in excess of the simplified acquisition threshold. In addition, a prime contractor with a contract in excess of $5 million for the procurement of items other than commercial items is required to conduct market research before making purchases that exceed the simplified acquisition threshold for or on behalf of the Government.

  15. 21 CFR 1304.26 - Additional recordkeeping requirements applicable to drug products containing gamma-hydroxybutyric...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... to drug products containing gamma-hydroxybutyric acid. 1304.26 Section 1304.26 Food and Drugs DRUG....26 Additional recordkeeping requirements applicable to drug products containing gamma-hydroxybutyric....22, practitioners dispensing gamma-hydroxybutyric acid that is manufactured or distributed in...

  16. 47 CFR 1.20007 - Additional assistance capability requirements for wireline, cellular, and PCS telecommunications...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Additional assistance capability requirements for wireline, cellular, and PCS telecommunications carriers. 1.20007 Section 1.20007 Telecommunication... telecommunications carriers. (a) Definition—(1) Call-identifying information. Call identifying information means...

  17. 47 CFR 1.20007 - Additional assistance capability requirements for wireline, cellular, and PCS telecommunications...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Additional assistance capability requirements for wireline, cellular, and PCS telecommunications carriers. 1.20007 Section 1.20007 Telecommunication... telecommunications carriers. (a) Definition—(1) Call-identifying information. Call identifying information means...

  18. 34 CFR 472.23 - What additional factor does the Secretary consider?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What additional factor does the Secretary consider? 472.23 Section 472.23 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION NATIONAL WORKPLACE LITERACY PROGRAM How...

  19. 34 CFR 648.32 - What additional factors does the Secretary consider?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What additional factors does the Secretary consider? 648.32 Section 648.32 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION GRADUATE ASSISTANCE IN AREAS OF NATIONAL NEED...

  20. 34 CFR 490.22 - What additional factor does the Secretary consider?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What additional factor does the Secretary consider? 490.22 Section 490.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION LIFE SKILLS FOR STATE AND LOCAL...

  1. 34 CFR 490.22 - What additional factor does the Secretary consider?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false What additional factor does the Secretary consider? 490.22 Section 490.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION LIFE SKILLS FOR STATE AND LOCAL...

  2. 12 CFR 1270.18 - Additional requirements; notice of attachment for Book-entry consolidated obligations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... for Book-entry consolidated obligations. 1270.18 Section 1270.18 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS LIABILITIES Book-Entry Procedure for Consolidated Obligations § 1270.18 Additional requirements; notice of attachment for Book-entry consolidated obligations. (a...

  3. 12 CFR 1270.18 - Additional requirements; notice of attachment for Book-entry consolidated obligations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... for Book-entry consolidated obligations. 1270.18 Section 1270.18 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS LIABILITIES Book-Entry Procedure for Consolidated Obligations § 1270.18 Additional requirements; notice of attachment for Book-entry consolidated obligations. (a...

  4. 12 CFR 1270.18 - Additional requirements; notice of attachment for Book-entry consolidated obligations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... for Book-entry consolidated obligations. 1270.18 Section 1270.18 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS LIABILITIES Book-Entry Procedure for Consolidated Obligations § 1270.18 Additional requirements; notice of attachment for Book-entry consolidated obligations. (a...

  5. 39 CFR 3050.13 - Additional documentation required in the Postal Service's section 3652 report.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Service's section 3652 report. 3050.13 Section 3050.13 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL PERIODIC REPORTING § 3050.13 Additional documentation required in the Postal Service's section... recent Annual Compliance Determination was issued and the reasons that those changes were accepted. ...

  6. Additive Factors Analysis of Inhibitory Processing in the Stop-Signal Paradigm

    ERIC Educational Resources Information Center

    van den Wildenberg, W.P.M.; van der Molen, M.W.

    2004-01-01

    This article reports an additive factors analysis of choice reaction and selective stop processes manipulated in a stop-signal paradigm. Three experiments were performed in which stimulus discriminability (SD) and stimulus-response compatibility (SRC) were manipulated in a factorial fashion. In each experiment, the effects of SD and SRC were…

  7. 36 CFR 1236.22 - What are the additional requirements for managing electronic mail records?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... requirements for managing electronic mail records? 1236.22 Section 1236.22 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT ELECTRONIC RECORDS MANAGEMENT Additional... accordance with the provisions of GRS 23, Item 5. (5) Draft documents that are circulated on electronic mail...

  8. 36 CFR 1236.22 - What are the additional requirements for managing electronic mail records?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... requirements for managing electronic mail records? 1236.22 Section 1236.22 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT ELECTRONIC RECORDS MANAGEMENT Additional... accordance with the provisions of GRS 23, Item 5. (5) Draft documents that are circulated on electronic mail...

  9. 36 CFR 1236.22 - What are the additional requirements for managing electronic mail records?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements for managing electronic mail records? 1236.22 Section 1236.22 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT ELECTRONIC RECORDS MANAGEMENT Additional... accordance with the provisions of GRS 23, Item 5. (5) Draft documents that are circulated on electronic mail...

  10. 36 CFR 1236.22 - What are the additional requirements for managing electronic mail records?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requirements for managing electronic mail records? 1236.22 Section 1236.22 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT ELECTRONIC RECORDS MANAGEMENT Additional... accordance with the provisions of GRS 23, Item 5. (5) Draft documents that are circulated on electronic mail...

  11. 49 CFR 173.301b - Additional general requirements for shipment of UN pressure receptacles.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... pressure receptacles. 173.301b Section 173.301b Transportation Other Regulations Relating to Transportation....301b Additional general requirements for shipment of UN pressure receptacles. (a) General. The... gases in UN pressure receptacles. A UN pressure receptacle, including closures, must conform to the...

  12. 26 CFR 1.46-7 - Statutory provisions; plan requirements for taxpayers electing additional investment credit, etc.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Investment in Certain Depreciable Property § 1.46-7 Statutory provisions; plan requirements for taxpayers electing additional investment credit, etc. As amended by sections 802(b)(7), and 803 (c), (d), and (e) of... taxpayers electing additional investment credit, etc. 1.46-7 Section 1.46-7 Internal Revenue INTERNAL...

  13. 19 CFR 191.103 - Additional requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TREASURY (CONTINUED) DRAWBACK Internal Revenue Tax on Flavoring Extracts and Medicinal or Toilet... requirements. (a) Manufacturer claims domestic drawback. In the case of medicinal preparations and flavoring... filed with the Bureau of Alcohol, Tobacco and Firearms for domestic drawback on medicinal preparations...

  14. 49 CFR 173.301b - Additional general requirements for shipment of UN pressure receptacles.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Group I performance level. (d) Non-refillable UN pressure receptacles. (1) When the use of a valve is... pressure receptacles. 173.301b Section 173.301b Transportation Other Regulations Relating to Transportation....301b Additional general requirements for shipment of UN pressure receptacles. (a) General. The...

  15. 49 CFR 173.301b - Additional general requirements for shipment of UN pressure receptacles.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Group I performance level. (d) Non-refillable UN pressure receptacles. (1) When the use of a valve is... pressure receptacles. 173.301b Section 173.301b Transportation Other Regulations Relating to Transportation....301b Additional general requirements for shipment of UN pressure receptacles. (a) General. The...

  16. 10 CFR 35.2647 - Records of additional technical requirements for mobile remote afterloader units.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... remote afterloader units. 35.2647 Section 35.2647 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL Records § 35.2647 Records of additional technical requirements for mobile remote afterloader units. (a) A licensee shall retain a record of each check for mobile remote afterloader units...

  17. 10 CFR 35.2647 - Records of additional technical requirements for mobile remote afterloader units.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... remote afterloader units. 35.2647 Section 35.2647 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL Records § 35.2647 Records of additional technical requirements for mobile remote afterloader units. (a) A licensee shall retain a record of each check for mobile remote afterloader units...

  18. 10 CFR 35.2647 - Records of additional technical requirements for mobile remote afterloader units.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... remote afterloader units. 35.2647 Section 35.2647 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL Records § 35.2647 Records of additional technical requirements for mobile remote afterloader units. (a) A licensee shall retain a record of each check for mobile remote afterloader units...

  19. 10 CFR 35.2647 - Records of additional technical requirements for mobile remote afterloader units.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... remote afterloader units. 35.2647 Section 35.2647 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL Records § 35.2647 Records of additional technical requirements for mobile remote afterloader units. (a) A licensee shall retain a record of each check for mobile remote afterloader units...

  20. 10 CFR 35.2647 - Records of additional technical requirements for mobile remote afterloader units.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... remote afterloader units. 35.2647 Section 35.2647 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL Records § 35.2647 Records of additional technical requirements for mobile remote afterloader units. (a) A licensee shall retain a record of each check for mobile remote afterloader units...

  1. 50 CFR 23.25 - What additional information is required on a non-Party CITES document?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ....25 What additional information is required on a non-Party CITES document? (a) Purpose. Under Article... Certification (1) Export (i) For Appendix-I and -II specimens, the Scientific Authority has advised that the...

  2. 33 CFR 203.83 - Additional requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... deteriorated components such as outlet structures and pipes, removal of debris, and new construction items such... furnishing flood fight assistance during an emergency. (b) Areas of minor damage, flood control works..., placing sod, or seeding completed work. (d) Adequacy of requirements of local cooperation. In determining...

  3. 40 CFR 96.76 - Additional requirements to provide heat input data for allocations purposes.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... TRADING PROGRAMS FOR STATE IMPLEMENTATION PLANS Monitoring and Reporting § 96.76 Additional requirements... to monitor and report NOX Mass emissions using a NOX concentration system and a flow system shall... chapter for any source located in a state developing source allocations based upon heat input. (b) The...

  4. Transcription factors lhx1/5-1 and pitx are required for the maintenance and regeneration of serotonergic neurons in planarians.

    PubMed

    Currie, Ko W; Pearson, Bret J

    2013-09-01

    In contrast to most adult organisms, freshwater planarians can regenerate any injured body part, including their entire nervous system. This allows for the analysis of genes required for both the maintenance and regeneration of specific neural subtypes. In addition, the loss of specific neural subtypes may uncover previously unknown behavioral roles for that neural population in the context of the adult animal. Here we show that two homeodomain transcription factor homologs, Smed-lhx1/5-1 and Smed-pitx, are required for the maintenance and regeneration of serotonergic neurons in planarians. When either lhx1/5-1 or pitx was knocked down by RNA interference, the expression of multiple canonical markers for serotonergic neurons was lost. Surprisingly, the loss of serotonergic function uncovered a role for these neurons in the coordination of motile cilia on the ventral epidermis of planarians that are required for their nonmuscular gliding locomotion. Finally, we show that in addition to its requirement in serotonergic neurons, Smed-pitx is required for proper midline patterning during regeneration, when it is required for the expression of the midline-organizing molecules Smed-slit in the anterior and Smed-wnt1 in the posterior.

  5. Postures and Motions Library Development for Verification of Ground Crew Human Factors Requirements

    NASA Technical Reports Server (NTRS)

    Stambolian, Damon; Henderson, Gena; Jackson, Mariea Dunn; Dischinger, Charles

    2013-01-01

    Spacecraft and launch vehicle ground processing activities require a variety of unique human activities. These activities are being documented in a primitive motion capture library. The library will be used by human factors engineering analysts to infuse real to life human activities into the CAD models to verify ground systems human factors requirements. As the primitive models are being developed for the library, the project has selected several current human factors issues to be addressed for the Space Launch System (SLS) and Orion launch systems. This paper explains how the motion capture of unique ground systems activities is being used to verify the human factors engineering requirements for ground systems used to process the SLS and Orion vehicles, and how the primitive models will be applied to future spacecraft and launch vehicle processing.

  6. 14 CFR 121.647 - Factors for computing fuel required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Factors for computing fuel required. 121.647 Section 121.647 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... this subpart shall consider the following: (a) Wind and other weather conditions forecast. (b...

  7. 14 CFR 121.647 - Factors for computing fuel required.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Factors for computing fuel required. 121.647 Section 121.647 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... this subpart shall consider the following: (a) Wind and other weather conditions forecast. (b...

  8. 14 CFR 121.647 - Factors for computing fuel required.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Factors for computing fuel required. 121.647 Section 121.647 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... this subpart shall consider the following: (a) Wind and other weather conditions forecast. (b...

  9. 14 CFR 121.647 - Factors for computing fuel required.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Factors for computing fuel required. 121.647 Section 121.647 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... this subpart shall consider the following: (a) Wind and other weather conditions forecast. (b...

  10. 14 CFR 121.647 - Factors for computing fuel required.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Factors for computing fuel required. 121.647 Section 121.647 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... this subpart shall consider the following: (a) Wind and other weather conditions forecast. (b...

  11. 49 CFR 171.24 - Additional requirements for the use of the ICAO Technical Instructions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Additional requirements for the use of the ICAO... the United States by aircraft, and by motor vehicle or rail either before or after being transported by aircraft in accordance with the ICAO Technical Instructions (IBR, see § 171.7), as authorized in...

  12. The RNA Export Factor, Nxt1, Is Required for Tissue Specific Transcriptional Regulation

    PubMed Central

    Jiang, Jianqiao; White-Cooper, Helen

    2013-01-01

    The highly conserved, Nxf/Nxt (TAP/p15) RNA nuclear export pathway is important for export of most mRNAs from the nucleus, by interacting with mRNAs and promoting their passage through nuclear pores. Nxt1 is essential for viability; using a partial loss of function allele, we reveal a role for this gene in tissue specific transcription. We show that many Drosophila melanogaster testis-specific mRNAs require Nxt1 for their accumulation. The transcripts that require Nxt1 also depend on a testis-specific transcription complex, tMAC. We show that loss of Nxt1 leads to reduced transcription of tMAC targets. A reporter transcript from a tMAC-dependent promoter is under-expressed in Nxt1 mutants, however the same transcript accumulates in mutants if driven by a tMAC-independent promoter. Thus, in Drosophila primary spermatocytes, the transcription factor used to activate expression of a transcript, rather than the RNA sequence itself or the core transcription machinery, determines whether this expression requires Nxt1. We additionally find that transcripts from intron-less genes are more sensitive to loss of Nxt1 function than those from intron-containing genes and propose a mechanism in which transcript processing feeds back to increase activity of a tissue specific transcription complex. PMID:23754955

  13. 20 CFR 30.518 - Can OWCP require the recipient of the overpayment to submit additional financial information?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... overpayment to submit additional financial information? 30.518 Section 30.518 Employees' Benefits OFFICE OF... OWCP require the recipient of the overpayment to submit additional financial information? (a) The... specified by OWCP. This information is needed to determine whether or not recovery of an overpayment would...

  14. 20 CFR 30.518 - Can OWCP require the recipient of the overpayment to submit additional financial information?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... overpayment to submit additional financial information? 30.518 Section 30.518 Employees' Benefits OFFICE OF... OWCP require the recipient of the overpayment to submit additional financial information? (a) The... specified by OWCP. This information is needed to determine whether or not recovery of an overpayment would...

  15. 20 CFR 30.518 - Can OWCP require the recipient of the overpayment to submit additional financial information?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... overpayment to submit additional financial information? 30.518 Section 30.518 Employees' Benefits OFFICE OF... OWCP require the recipient of the overpayment to submit additional financial information? (a) The... specified by OWCP. This information is needed to determine whether or not recovery of an overpayment would...

  16. 77 FR 38147 - Additional Requirements for Charitable Hospitals

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-26

    ... which the requirements of section 501(r) are not separately met. Community Health Needs Assessments Section 501(r)(3) requires a hospital organization to conduct a community health needs assessment (CHNA) at least once every three years and adopt an implementation strategy to meet the community health...

  17. 40 CFR 60.1275 - What additional requirements must I meet for the operation of my continuous emission monitoring...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... meet for the operation of my continuous emission monitoring systems and continuous opacity monitoring... additional requirements must I meet for the operation of my continuous emission monitoring systems and continuous opacity monitoring system? Use the required span values and applicable performance specifications...

  18. 40 CFR 60.1275 - What additional requirements must I meet for the operation of my continuous emission monitoring...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... meet for the operation of my continuous emission monitoring systems and continuous opacity monitoring... additional requirements must I meet for the operation of my continuous emission monitoring systems and continuous opacity monitoring system? Use the required span values and applicable performance specifications...

  19. 49 CFR 173.302a - Additional requirements for shipment of nonliquefied (permanent) compressed gases in...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... hydrogen. When used in methane service, the methane must be a nonliquefied gas with a minimum purity of 98... nonliquefied (permanent) compressed gases in specification cylinders. 173.302a Section 173.302a Transportation... PACKAGINGS Gases; Preparation and Packaging § 173.302a Additional requirements for shipment of nonliquefied...

  20. 20 CFR 664.210 - How is the “requires additional assistance to complete an educational program, or to secure and...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false How is the ârequires additional assistance to complete an educational program, or to secure and hold employmentâ criterion in § 664.200(c)(6) defined... Services § 664.210 How is the “requires additional assistance to complete an educational program, or to...

  1. 14 CFR 135.169 - Additional airworthiness requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... airplane type certificated after January 1, 1958, must have ceiling and sidewall panels which are constructed of: (i) Glass fiber reinforced resin; (ii) Materials which meet the test requirements of part 25...

  2. Identification and characterization of an oocyte factor required for development of porcine nuclear transfer embryos

    PubMed Central

    Miyamoto, Kei; Nagai, Kouhei; Kitamura, Naoya; Nishikawa, Tomoaki; Ikegami, Haruka; Binh, Nguyen T.; Tsukamoto, Satoshi; Matsumoto, Mai; Tsukiyama, Tomoyuki; Minami, Naojiro; Yamada, Masayasu; Ariga, Hiroyoshi; Miyake, Masashi; Kawarasaki, Tatsuo; Matsumoto, Kazuya; Imai, Hiroshi

    2011-01-01

    Nuclear reprogramming of differentiated cells can be induced by oocyte factors. Despite numerous attempts, these factors and mechanisms responsible for successful reprogramming remain elusive. Here, we identify one such factor, necessary for the development of nuclear transfer embryos, using porcine oocyte extracts in which some reprogramming events are recapitulated. After incubating somatic nuclei in oocyte extracts from the metaphase II stage, the oocyte proteins that were specifically and abundantly incorporated into the nuclei were identified by mass spectrometry. Among 25 identified proteins, we especially focused on a multifunctional protein, DJ-1. DJ-1 is present at a high concentration in oocytes from the germinal vesicle stage until embryos at the four-cell stage. Inhibition of DJ-1 function compromises the development of nuclear transfer embryos but not that of fertilized embryos. Microarray analysis of nuclear transfer embryos in which DJ-1 function is inhibited shows perturbed expression of P53 pathway components. In addition, embryonic arrest of nuclear transfer embryos injected with anti–DJ-1 antibody is rescued by P53 inhibition. We conclude that DJ-1 is an oocyte factor that is required for development of nuclear transfer embryos. This study presents a means for identifying natural reprogramming factors in mammalian oocytes and a unique insight into the mechanisms underlying reprogramming by nuclear transfer. PMID:21482765

  3. Human milk inactivates pathogens individually, additively, and synergistically.

    PubMed

    Isaacs, Charles E

    2005-05-01

    Breast-feeding can reduce the incidence and the severity of gastrointestinal and respiratory infections in the suckling neonate by providing additional protective factors to the infant's mucosal surfaces. Human milk provides protection against a broad array of infectious agents through redundancy. Protective factors in milk can target multiple early steps in pathogen replication and target each step with more than one antimicrobial compound. The antimicrobial activity in human milk results from protective factors working not only individually but also additively and synergistically. Lipid-dependent antimicrobial activity in milk results from the additive activity of all antimicrobial lipids and not necessarily the concentration of one particular lipid. Antimicrobial milk lipids and peptides can work synergistically to decrease both the concentrations of individual compounds required for protection and, as importantly, greatly reduce the time needed for pathogen inactivation. The more rapidly pathogens are inactivated the less likely they are to establish an infection. The total antimicrobial protection provided by human milk appears to be far more than can be elucidated by examining protective factors individually.

  4. 40 CFR 80.591 - What are the product transfer document requirements for additives to be used in diesel fuel?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... requirements for additives to be used in diesel fuel? 80.591 Section 80.591 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES... additives to be used in diesel fuel? (a) Except as provided in paragraphs (b) and (d) of this section, on...

  5. 40 CFR 80.591 - What are the product transfer document requirements for additives to be used in diesel fuel?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... requirements for additives to be used in diesel fuel? 80.591 Section 80.591 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES... additives to be used in diesel fuel? (a) Except as provided in paragraphs (b) and (d) of this section, on...

  6. 40 CFR 80.591 - What are the product transfer document requirements for additives to be used in diesel fuel?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements for additives to be used in diesel fuel? 80.591 Section 80.591 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES... additives to be used in diesel fuel? (a) Except as provided in paragraphs (b) and (d) of this section, on...

  7. 40 CFR 80.591 - What are the product transfer document requirements for additives to be used in diesel fuel?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requirements for additives to be used in diesel fuel? 80.591 Section 80.591 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES... additives to be used in diesel fuel? (a) Except as provided in paragraphs (b) and (d) of this section, on...

  8. 40 CFR 80.591 - What are the product transfer document requirements for additives to be used in diesel fuel?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... requirements for additives to be used in diesel fuel? 80.591 Section 80.591 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES... additives to be used in diesel fuel? (a) Except as provided in paragraphs (b) and (d) of this section, on...

  9. 14 CFR 121.317 - Passenger information requirements, smoking prohibitions, and additional seat belt requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Passenger information requirements, smoking... OPERATIONS Instrument and Equipment Requirements § 121.317 Passenger information requirements, smoking... command. (c) No person may operate an airplane on a flight on which smoking is prohibited by part 252 of...

  10. 14 CFR 121.317 - Passenger information requirements, smoking prohibitions, and additional seat belt requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Passenger information requirements, smoking... OPERATIONS Instrument and Equipment Requirements § 121.317 Passenger information requirements, smoking... command. (c) No person may operate an airplane on a flight on which smoking is prohibited by part 252 of...

  11. 14 CFR 121.317 - Passenger information requirements, smoking prohibitions, and additional seat belt requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Passenger information requirements, smoking... OPERATIONS Instrument and Equipment Requirements § 121.317 Passenger information requirements, smoking... command. (c) No person may operate an airplane on a flight on which smoking is prohibited by part 252 of...

  12. 14 CFR 121.317 - Passenger information requirements, smoking prohibitions, and additional seat belt requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Passenger information requirements, smoking... OPERATIONS Instrument and Equipment Requirements § 121.317 Passenger information requirements, smoking... command. (c) No person may operate an airplane on a flight on which smoking is prohibited by part 252 of...

  13. 14 CFR 121.317 - Passenger information requirements, smoking prohibitions, and additional seat belt requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Passenger information requirements, smoking... OPERATIONS Instrument and Equipment Requirements § 121.317 Passenger information requirements, smoking... command. (c) No person may operate an airplane on a flight on which smoking is prohibited by part 252 of...

  14. Alloy-steel nuts for bolting for high-pressure and high-temperature service (ASME SA-194 with additional requirements)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    This standard covers alloy steel nuts for bolting for high-pressure and high-temperature service in nuclear and associated applications. This standard does not cover bar or other starting materials. The only implied special considerations for starting materials are that they be capable of passing the required tests when processed into finished products in accordance with this standard. Material shall conform to the requirements of ASME SA-194; to the requirements of the ASME Boiler and Pressure Vessel Code (ASME Code), Section III, Article NB-2000; to the requirements of NE E 8-18; and to the additional requirements of this standard.

  15. Additional risk factors for lethal hypothermia.

    PubMed

    Bright, Fiona; Gilbert, John D; Winskog, Calle; Byard, Roger W

    2013-08-01

    An 86-year-old woman was found dead lying on her back on the floor of an unkempt kitchen. She had last been seen four days before. Her dress was pulled up and she was not wearing underpants. The house was noted to be in "disarray" with papers covering most surfaces and the floor. Rubbish was piled up against one of the doors. At autopsy the major findings were of a fractured left neck of femur, fresh pressure areas over her right buttock, Wischnewski spots of the stomach and foci of pancreatic necrosis, in keeping with hypothermia. No significant underlying organic diseases were identified and there was no other evidence of trauma. Death was due to hypothermia complicating immobility from a fractured neck of femur. This case confirms the vulnerability of frail, elderly and socially-isolated individuals to death from hypothermia if a significant illness or injury occurs. Additional risk factors for hypothermia are also illustrated in this case that involve inadequate housing construction with absent insulation and window double glazing. The approach to hypothermic deaths should, therefore, include checking for these features as well as measuring room and environmental temperatures, evaluating the type and quality of heating and the nature of the floor and its coverings, Given the ageing population in many Western countries, increasing social isolation of the elderly, cost of fuel and electricity, and lack of energy efficient housing, this type of death may become an increasingly witnessed occurrence during the colder months of the year. Copyright © 2012 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  16. NUCLEAR FACTOR Y Transcription Factors Have Both Opposing and Additive Roles in ABA-Mediated Seed Germination

    PubMed Central

    Kumimoto, Roderick W.; Siriwardana, Chamindika L.; Gayler, Krystal K.; Risinger, Jan R.; Siefers, Nicholas; Holt, Ben F.

    2013-01-01

    In the model organism Arabidopsis thaliana the heterotrimeric transcription factor NUCLEAR FACTOR Y (NF-Y) has been shown to play multiple roles in facilitating plant growth and development. Although NF-Y itself represents a multi-protein transcriptional complex, recent studies have shown important interactions with other transcription factors, especially those in the bZIP family. Here we add to the growing evidence that NF-Y and bZIP form common complexes to affect many processes. We carried out transcriptional profiling on nf-yc mutants and through subsequent analyses found an enrichment of bZIP binding sites in the promoter elements of misregulated genes. Using NF-Y as bait, yeast two hybrid assays yielded interactions with bZIP proteins that are known to control ABA signaling. Accordingly, we find that plants mutant for several NF-Y subunits show characteristic phenotypes associated with the disruption of ABA signaling. While previous reports have shown additive roles for NF-YC family members in photoperiodic flowering, we found that they can have opposing roles in ABA signaling. Collectively, these results demonstrated the importance and complexity of NF-Y in the integration of environmental and hormone signals. PMID:23527203

  17. Human Factors Engineering Requirements for the International Space Station - Successes and Challenges

    NASA Technical Reports Server (NTRS)

    Whitmore, M.; Blume, J.

    2003-01-01

    Advanced technology coupled with the desire to explore space has resulted in increasingly longer human space missions. Indeed, any exploration mission outside of Earth's neighborhood, in other words, beyond the moon, will necessarily be several months or even years. The International Space Station (ISS) serves as an important advancement toward executing a successful human space mission that is longer than a standard trip around the world or to the moon. The ISS, which is a permanently occupied microgravity research facility orbiting the earth, will support missions four to six months in duration. In planning for the ISS, the NASA developed an agency-wide set of human factors standards for the first time in a space exploration program. The Man-Systems Integration Standard (MSIS), NASA-STD-3000, a multi-volume set of guidelines for human-centered design in microgravity, was developed with the cooperation of human factors experts from various NASA centers, industry, academia, and other government agencies. The ISS program formed a human factors team analogous to any major engineering subsystem. This team develops and maintains the human factors requirements regarding end-to-end architecture design and performance, hardware and software design requirements, and test and verification requirements. It is also responsible for providing program integration across all of the larger scale elements, smaller scale hardware, and international partners.

  18. The RNA Polymerase-Associated Factor 1 Complex Is Required for Plant Touch Responses

    PubMed Central

    Jensen, Gregory S.; Fal, Kateryna; Hamant, Olivier

    2017-01-01

    Abstract Thigmomorphogenesis is a stereotypical developmental alteration in the plant body plan that can be induced by repeatedly touching plant organs. To unravel how plants sense and record multiple touch stimuli we performed a novel forward genetic screen based on the development of a shorter stem in response to repetitive touch. The touch insensitive (ths1) mutant identified in this screen is defective in some aspects of shoot and root thigmomorphogenesis. The ths1 mutant is an intermediate loss-of-function allele of VERNALIZATION INDEPENDENCE 3 (VIP3), a previously characterized gene whose product is part of the RNA polymerase II-associated factor 1 (Paf1) complex. The Paf1 complex is found in yeast, plants and animals, and has been implicated in histone modification and RNA processing. Several components of the Paf1 complex are required for reduced stem height in response to touch and normal root slanting and coiling responses. Global levels of histone H3K36 trimethylation are reduced in VIP3 mutants. In addition, THS1/VIP3 is required for wild type histone H3K36 trimethylation at the TOUCH3 (TCH3) and TOUCH4 (TCH4) loci and for rapid touch-induced upregulation of TCH3 and TCH4 transcripts. Thus, an evolutionarily conserved chromatin-modifying complex is required for both short- and long-term responses to mechanical stimulation, providing insight into how plants record mechanical signals for thigmomorphogenesis. PMID:28204553

  19. Factors associated with higher oxytocin requirements in labor.

    PubMed

    Frey, Heather A; Tuuli, Methodius G; England, Sarah K; Roehl, Kimberly A; Odibo, Anthony O; Macones, George A; Cahill, Alison G

    2015-09-01

    To identify clinical characteristics associated with high maximum oxytocin doses in women who achieve complete cervical dilation. A retrospective nested case-control study was performed within a cohort of all term women at a single center between 2004 and 2008 who reached the second stage of labor. Cases were defined as women who had a maximum oxytocin dose during labor >20 mu/min, while women in the control group had a maximum oxytocin dose during labor of ≤20 mu/min. Exclusion criteria included no oxytocin administration during labor, multiple gestations, major fetal anomalies, nonvertex presentation, and prior cesarean delivery. Multiple maternal, fetal, and labor factors were evaluated with univariable analysis and multivariable logistic regression. Maximum oxytocin doses >20 mu/min were administered to 108 women (3.6%), while 2864 women received doses ≤20 mu/min. Factors associated with higher maximum oxytocin dose after adjusting for relevant confounders included maternal diabetes, birthweight >4000 g, intrapartum fever, administration of magnesium, and induction of labor. Few women who achieve complete cervical dilation require high doses of oxytocin. We identified maternal, fetal and labor factors that characterize this group of parturients.

  20. Risk Factors for Uterine Atony/Postpartum Hemorrhage Requiring Treatment after Vaginal Delivery

    PubMed Central

    Wetta, Luisa A; Szychowski, Jeff M; Seals, Ms. Samantha; Mancuso, Melissa S; Biggio, Joseph R; Tita, Alan TN

    2013-01-01

    Objective To identify risk factors for uterine atony or hemorrhage. Study Design Secondary analysis of a 3-arm double-blind randomized trial of different dose-regimens of oxytocin to prevent uterine atony after vaginal delivery. The primary outcome was uterine atony or hemorrhage requiring treatment. Twenty-one potential risk factors were evaluated. Logistic regression was used to identify independent risk factors using 2 complementary pre-defined model selection strategies. Results Among 1798 women randomized to 10, 40 or 80U prophylactic oxytocin after vaginal delivery, treated uterine atony occurred in 7%. Hispanic (OR 2.1; 95% CI 1.3–3.4) and non-Hispanic whites (OR 1.6; 95% CI 1.0–2.5), preeclampsia (OR 3.2; 95% CI 2.0–4.9) and chorioamnionitis (OR 2.8; 95% CI 1.6–5.0) were consistent independent risk factors. Other risk factors based on the specified selection strategies were obesity, induction/augmentation of labor, twins, hydramnios, anemia, and arrest of descent. Amnioinfusion appeared to be protective against uterine atony (OR 0.53; 95% CI 0.29–0.98). Conclusion Independent risk factors for uterine atony requiring treatment include Hispanic and non-Hispanic white ethnicity, preeclampsia and chorioamnionitis. PMID:23507549

  1. 14 CFR 135.421 - Additional maintenance requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... programs, or a program approved by the Administrator, for each aircraft engine, propeller, rotor, and each... instructions set forth by the manufacturer as required by this chapter for the aircraft, aircraft engine, propeller, rotor or item of emergency equipment. (c) For each single engine aircraft to be used in passenger...

  2. 14 CFR 135.421 - Additional maintenance requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... programs, or a program approved by the Administrator, for each aircraft engine, propeller, rotor, and each... instructions set forth by the manufacturer as required by this chapter for the aircraft, aircraft engine, propeller, rotor or item of emergency equipment. (c) For each single engine aircraft to be used in passenger...

  3. 14 CFR 135.421 - Additional maintenance requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... programs, or a program approved by the Administrator, for each aircraft engine, propeller, rotor, and each... instructions set forth by the manufacturer as required by this chapter for the aircraft, aircraft engine, propeller, rotor or item of emergency equipment. (c) For each single engine aircraft to be used in passenger...

  4. 14 CFR 135.421 - Additional maintenance requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... programs, or a program approved by the Administrator, for each aircraft engine, propeller, rotor, and each... instructions set forth by the manufacturer as required by this chapter for the aircraft, aircraft engine, propeller, rotor or item of emergency equipment. (c) For each single engine aircraft to be used in passenger...

  5. 14 CFR 135.421 - Additional maintenance requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... programs, or a program approved by the Administrator, for each aircraft engine, propeller, rotor, and each... instructions set forth by the manufacturer as required by this chapter for the aircraft, aircraft engine, propeller, rotor or item of emergency equipment. (c) For each single engine aircraft to be used in passenger...

  6. A Handbook of Flight Simulation Fidelity Required for Human Factors Research

    DOT National Transportation Integrated Search

    1995-12-01

    This report examines relevant literature for guidelines relative to the use of : flight simulators, ranging from full mission to part-task trainers, in addition : to requirements for flight crew experience and qualifications. Both sets of : guideline...

  7. 34 CFR 403.174 - What additional fiscal requirements apply to the Business-Labor-Education Partnership for...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What additional fiscal requirements apply to the Business-Labor-Education Partnership for Training Program? 403.174 Section 403.174 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION...

  8. 34 CFR 403.174 - What additional fiscal requirements apply to the Business-Labor-Education Partnership for...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false What additional fiscal requirements apply to the Business-Labor-Education Partnership for Training Program? 403.174 Section 403.174 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION...

  9. 34 CFR 403.174 - What additional fiscal requirements apply to the Business-Labor-Education Partnership for...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false What additional fiscal requirements apply to the Business-Labor-Education Partnership for Training Program? 403.174 Section 403.174 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION...

  10. 34 CFR 403.174 - What additional fiscal requirements apply to the Business-Labor-Education Partnership for...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false What additional fiscal requirements apply to the Business-Labor-Education Partnership for Training Program? 403.174 Section 403.174 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION...

  11. 34 CFR 403.174 - What additional fiscal requirements apply to the Business-Labor-Education Partnership for...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false What additional fiscal requirements apply to the Business-Labor-Education Partnership for Training Program? 403.174 Section 403.174 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION...

  12. 49 CFR 172.402 - Additional labeling requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 30, 2001, such as, a label without the hazard class or division number displayed in the lower corner... this section); and (2)For other than Class 1 or Class 2 materials (for subsidiary labeling requirements for Class 1 or Class 2 materials see paragraph (e) or paragraphs (f) and (g), respectively, of this...

  13. Additive manufacturing in production: challenges and opportunities

    NASA Astrophysics Data System (ADS)

    Ahuja, Bhrigu; Karg, Michael; Schmidt, Michael

    2015-03-01

    Additive manufacturing, characterized by its inherent layer by layer fabrication methodology has been coined by many as the latest revolution in the manufacturing industry. Due to its diversification of Materials, processes, system technology and applications, Additive Manufacturing has been synonymized with terminology such as Rapid prototyping, 3D printing, free-form fabrication, Additive Layer Manufacturing, etc. A huge media and public interest in the technology has led to an innovative attempt of exploring the technology for applications beyond the scope of the traditional engineering industry. Nevertheless, it is believed that a critical factor for the long-term success of Additive Manufacturing would be its ability to fulfill the requirements defined by the traditional manufacturing industry. A parallel development in market trends and product requirements has also lead to a wider scope of opportunities for Additive Manufacturing. The presented paper discusses some of the key challenges which are critical to ensure that Additive Manufacturing is truly accepted as a mainstream production technology in the industry. These challenges would highlight on various aspects of production such as product requirements, process management, data management, intellectual property, work flow management, quality assurance, resource planning, etc. In Addition, changing market trends such as product life cycle, mass customization, sustainability, environmental impact and localized production will form the foundation for the follow up discussion on the current limitations and the corresponding research opportunities. A discussion on ongoing research to address these challenges would include topics like process monitoring, design complexity, process standardization, multi-material and hybrid fabrication, new material development, etc.

  14. The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species.

    PubMed

    Monaghan-Benson, Elizabeth; Burridge, Keith

    2009-09-18

    Vascular permeability is a complex process involving the coordinated regulation of multiple signaling pathways in the endothelial cell. It has long been documented that vascular endothelial growth factor (VEGF) greatly enhances microvascular permeability; however, the molecular mechanisms controlling VEGF-induced permeability remain unknown. Treatment of microvascular endothelial cells with VEGF led to an increase in reactive oxygen species (ROS) production. ROS are required for VEGF-induced permeability as treatment with the free radical scavenger, N-acetylcysteine, inhibited this effect. Additionally, treatment with VEGF caused ROS-dependent tyrosine phosphorylation of both vascular-endothelial (VE)-cadherin and beta-catenin. Rac1 was required for the VEGF-induced increase in permeability and adherens junction protein phosphorylation. Knockdown of Rac1 inhibited VEGF-induced ROS production consistent with Rac lying upstream of ROS in this pathway. Collectively, these data suggest that VEGF leads to a Rac-mediated generation of ROS, which, in turn, elevates the tyrosine phosphorylation of VE-cadherin and beta-catenin, ultimately regulating adherens junction integrity.

  15. 40 CFR 80.410 - What are the additional requirements for gasoline produced at foreign refineries having...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 17 2014-07-01 2014-07-01 false What are the additional requirements... knowledge and belief after I have taken reasonable and appropriate steps to verify the accuracy thereof. I... States Code, section 1001, the penalty for furnishing false, incomplete or misleading information in this...

  16. 40 CFR 80.410 - What are the additional requirements for gasoline produced at foreign refineries having...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false What are the additional requirements... knowledge and belief after I have taken reasonable and appropriate steps to verify the accuracy thereof. I... States Code, section 1001, the penalty for furnishing false, incomplete or misleading information in this...

  17. 40 CFR 80.410 - What are the additional requirements for gasoline produced at foreign refineries having...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 17 2012-07-01 2012-07-01 false What are the additional requirements... knowledge and belief after I have taken reasonable and appropriate steps to verify the accuracy thereof. I... States Code, section 1001, the penalty for furnishing false, incomplete or misleading information in this...

  18. 40 CFR 80.410 - What are the additional requirements for gasoline produced at foreign refineries having...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 16 2011-07-01 2011-07-01 false What are the additional requirements... knowledge and belief after I have taken reasonable and appropriate steps to verify the accuracy thereof. I... States Code, section 1001, the penalty for furnishing false, incomplete or misleading information in this...

  19. 40 CFR 80.410 - What are the additional requirements for gasoline produced at foreign refineries having...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false What are the additional requirements... knowledge and belief after I have taken reasonable and appropriate steps to verify the accuracy thereof. I... States Code, section 1001, the penalty for furnishing false, incomplete or misleading information in this...

  20. Communication requirements of sparse Cholesky factorization with nested dissection ordering

    NASA Technical Reports Server (NTRS)

    Naik, Vijay K.; Patrick, Merrell L.

    1989-01-01

    Load distribution schemes for minimizing the communication requirements of the Cholesky factorization of dense and sparse, symmetric, positive definite matrices on multiprocessor systems are presented. The total data traffic in factoring an n x n sparse symmetric positive definite matrix representing an n-vertex regular two-dimensional grid graph using n exp alpha, alpha not greater than 1, processors are shown to be O(n exp 1 + alpha/2). It is O(n), when n exp alpha, alpha not smaller than 1, processors are used. Under the conditions of uniform load distribution, these results are shown to be asymptotically optimal.

  1. Biomedical and Human Factors Requirements for a Manned Earth Orbiting Station

    NASA Technical Reports Server (NTRS)

    Helvey, W.; Martell, C.; Peters, J.; Rosenthal, G.; Benjamin, F.; Albright, G.

    1964-01-01

    The primary objective of this study is to determine which biomedical and human factors measurements must be made aboard a space station to assure adequate evaluation of the astronaut's health and performance during prolonged space flights. The study has employed, where possible, a medical and engineering systems analysis to define the pertinent life sciences and space station design parameters and their influence on a measurement program. The major areas requiring evaluation in meeting the study objectives include a definition of the space environment, man's response to the environment, selection of measurement and data management techniques, experimental program, space station design requirements, and a trade-off analysis with final recommendations. The space environment factors that are believed to have a significant effect on man were evaluated. This includes those factors characteristic of the space environment (e. g. weightlessness, radiation) as well as those created within the space station (e. g. toxic contaminants, capsule atmosphere). After establishing the general features of the environment, an appraisal was made of the anticipated response of the astronaut to each of these factors. For thoroughness, the major organ systems and functions of the body were delineated, and a determination was made of their anticipated response to each of the environmental categories. A judgment was then made on the medical significance or importance of each response, which enabled a determination of which physiological and psychological effects should be monitored. Concurrently, an extensive list of measurement techniques and methods of data management was evaluated for applicability to the space station program. The various space station configurations and design parameters were defined in terms of the biomedical and human factors requirements to provide the measurements program. Research design of experimental programs for various station configurations, mission

  2. The GATA transcription factor gene gtaG is required for terminal differentiation in Dictyostelium.

    PubMed

    Katoh-Kurasawa, Mariko; Santhanam, Balaji; Shaulsky, Gad

    2016-03-09

    The GATA transcription factor GtaG is conserved in Dictyostelids and essential for terminal differentiation in Dictyostelium discoideum, but its function is not well understood. Here we show that gtaG is expressed in prestalk cells at the anterior region of fingers and in the extending stalk during culmination. The gtaG - phenotype is cell-autonomous in prestalk cells and non-cell-autonomous in prespore cells. Transcriptome analyses reveal that GtaG regulates prestalk gene expression during cell differentiation before culmination and is required for progression into culmination. GtaG-dependent genes include genetic suppressors of the Dd-STATa-defective phenotype as well as Dd-STATa target-genes, including extra cellular matrix genes. We show that GtaG may be involved in the production of two culmination-signaling molecules, cyclic di-GMP and the spore differentiation factor SDF-1 and that addition of c-di-GMP rescues the gtaG - culmination and spore formation deficiencies. We propose that GtaG is a regulator of terminal differentiation that functions in concert with Dd-STATa and controls culmination through regulating c-di-GMP and SDF-1 production in prestalk cells. © 2016. Published by The Company of Biologists Ltd.

  3. Fibroblast growth factor signaling is required for early somatic gonad development in zebrafish.

    PubMed

    Leerberg, Dena M; Sano, Kaori; Draper, Bruce W

    2017-09-01

    The vertebrate ovary and testis develop from a sexually indifferent gonad. During early development of the organism, primordial germ cells (the gamete lineage) and somatic gonad cells coalesce and begin to undergo growth and morphogenesis to form this bipotential gonad. Although this aspect of development is requisite for a fertile adult, little is known about the genetic regulation of early gonadogenesis in any vertebrate. Here, we provide evidence that fibroblast growth factor (Fgf) signaling is required for the early growth phase of a vertebrate bipotential gonad. Based on mutational analysis in zebrafish, we show that the Fgf ligand 24 (Fgf24) is required for proliferation, differentiation, and morphogenesis of the early somatic gonad, and as a result, most fgf24 mutants are sterile as adults. Additionally, we describe the ultrastructural elements of the early zebrafish gonad and show that distinct somatic cell populations can be identified soon after the gonad forms. Specifically, we show that fgf24 is expressed in an epithelial population of early somatic gonad cells that surrounds an inner population of mesenchymal somatic gonad cells that are in direct contact with the germ cells, and that fgf24 is required for stratification of the somatic tissue. Furthermore, based on gene expression analysis, we find that differentiation of the inner mesenchymal somatic gonad cells into functional cell types in the larval and early juvenile-stage gonad is dependent on Fgf24 signaling. Finally, we argue that the role of Fgf24 in zebrafish is functionally analogous to the role of tetrapod FGF9 in early gonad development.

  4. Current good manufacturing practices, quality control procedures, quality factors, notification requirements, and records and reports, for infant formula. Final rule.

    PubMed

    2014-06-10

    The Food and Drug Administration (FDA or we) is issuing a final rule that adopts, with some modifications, the interim final rule (IFR) entitled "Current Good Manufacturing Practices, Quality Control Procedures, Quality Factors, Notification Requirements, and Records and Reports, for Infant Formula'' (February 10, 2014). This final rule affirms the IFR's changes to FDA's regulations and provides additional modifications and clarifications. The final rule also responds to certain comments submitted in response to the request for comments in the IFR.

  5. 36 CFR 1236.28 - What additional requirements apply to the selection and maintenance of electronic records storage...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... apply to the selection and maintenance of electronic records storage media for permanent records? 1236... What additional requirements apply to the selection and maintenance of electronic records storage media for permanent records? (a) Agencies must maintain the storage and test areas for electronic records...

  6. 36 CFR 1236.28 - What additional requirements apply to the selection and maintenance of electronic records storage...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... apply to the selection and maintenance of electronic records storage media for permanent records? 1236... What additional requirements apply to the selection and maintenance of electronic records storage media for permanent records? (a) Agencies must maintain the storage and test areas for electronic records...

  7. 14 CFR 61.31 - Type rating requirements, additional training, and authorization requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... goggle operation flight planning, including night terrain interpretation and factors affecting terrain... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND... Administrator has authorized the flight or series of flights; (2) The Administrator has determined that an...

  8. 14 CFR 61.31 - Type rating requirements, additional training, and authorization requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... goggle operation flight planning, including night terrain interpretation and factors affecting terrain... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND... Administrator has authorized the flight or series of flights; (2) The Administrator has determined that an...

  9. 14 CFR 61.31 - Type rating requirements, additional training, and authorization requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... goggle operation flight planning, including night terrain interpretation and factors affecting terrain... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND... Administrator has authorized the flight or series of flights; (2) The Administrator has determined that an...

  10. The Ethylene Responsive Factor Required for Nodulation 1 (ERN1) Transcription Factor Is Required for Infection-Thread Formation in Lotus japonicus.

    PubMed

    Kawaharada, Yasuyuki; James, Euan K; Kelly, Simon; Sandal, Niels; Stougaard, Jens

    2017-03-01

    Several hundred genes are transcriptionally regulated during infection-thread formation and development of nitrogen-fixing root nodules. We have characterized a set of Lotus japonicus mutants impaired in root-nodule formation and found that the causative gene, Ern1, encodes a protein with a characteristic APETALA2/Ethylene Responsive Factor (AP2/ERF) transcription-factor domain. Phenotypic characterization of four ern1 alleles shows that infection pockets are formed but root-hair infection threads are absent. Formation of root-nodule primordia is delayed and no normal transcellular infection threads are found in the infected nodules. Corroborating the role of ERN1 (ERF Required for Nodulation1) in nodule organogenesis, spontaneous nodulation induced by an autoactive CCaMK and cytokinin-induced nodule primordia were not observed in ern1 mutants. Expression of Ern1 is induced in the susceptible zone by Nod factor treatment or rhizobial inoculation. At the cellular level, the pErn1:GUS reporter is highly expressed in root epidermal cells of the susceptible zone and in the cortical cells that form nodule primordia. The genetic regulation of this cellular expression pattern was further investigated in symbiotic mutants. Nod factor induction of Ern1 in epidermal cells was found to depend on Nfr1, Cyclops, and Nsp2 but was independent of Nin and Nf-ya1. These results suggest that ERN1 functions as a transcriptional regulator involved in the formation of infection threads and development of nodule primordia and may coordinate these two processes.

  11. The Role of Drugs, Diet, and Food Additives in Hyperactivity.

    ERIC Educational Resources Information Center

    Harshbarger, Mary E.

    A variety of causes have been suggested for hyperactivity: anoxia and other adverse birth conditions, genetic factors, delayed maturation, maternal smoking and drinking during pregnancy, interaction of temperament and environment, lead poisoning, radiation stress, allergy and food additives, and deprivation of required stimulation. Treatments…

  12. Enhancer Activation Requires Trans-Recruitment of a Mega Transcription Factor Complex

    PubMed Central

    Liu, Zhijie; Merkurjev, Daria; Yang, Feng; Li, Wenbo; Oh, Soohwan; Friedman, Meyer J.; Song, Xiaoyuan; Zhang, Feng; Ma, Qi; Ohgi, Kenneth; Krones, Anna; Rosenfeld, Michael G.

    2014-01-01

    Summary Enhancers provide critical information directing cell-type specific transcriptional programs, regulated by binding of signal-dependent transcription factors and their associated cofactors. Here we report that the most strongly activated estrogen (E2)-responsive enhancers are characterized by trans-recruitment and in situ assembly of a large 1-2 MDa complex of diverse DNA-binding transcription factors by ERα at ERE-containing enhancers. We refer to enhancers recruiting these factors as mega transcription factor-bound in trans (MegaTrans) enhancers. The MegaTrans complex is a signature of the most potent functional enhancers and is required for activation of enhancer RNA transcription and recruitment of coactivators, including p300 and Med1. The MegaTrans complex functions, in part, by recruiting specific enzymatic machinery, exemplified by DNA-dependent protein kinase. Thus, MegaTrans-containing enhancers represent a cohort of functional enhancers that mediate a broad and important transcriptional program and provide a molecular explanation for transcription factor clustering and hotspots noted in the genome. PMID:25303530

  13. 46 CFR 72.01-25 - Additional structural requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... inner skins shall be tested with water to-a-head corresponding to the requirements of paragraph (a)(1) of this section upon completion of construction. (6) The watertight space enclosing the stern tube...

  14. 46 CFR 72.01-25 - Additional structural requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... inner skins shall be tested with water to-a-head corresponding to the requirements of paragraph (a)(1) of this section upon completion of construction. (6) The watertight space enclosing the stern tube...

  15. 46 CFR 72.01-25 - Additional structural requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... inner skins shall be tested with water to-a-head corresponding to the requirements of paragraph (a)(1) of this section upon completion of construction. (6) The watertight space enclosing the stern tube...

  16. 46 CFR 72.01-25 - Additional structural requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... inner skins shall be tested with water to-a-head corresponding to the requirements of paragraph (a)(1) of this section upon completion of construction. (6) The watertight space enclosing the stern tube...

  17. 20 CFR 10.332 - What additional medical information will OWCP require to support continuing payment of benefits?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false What additional medical information will OWCP require to support continuing payment of benefits? 10.332 Section 10.332 Employees' Benefits OFFICE OF... COMPENSATION UNDER THE FEDERAL EMPLOYEES' COMPENSATION ACT, AS AMENDED Medical and Related Benefits Medical...

  18. 42 CFR 130.24 - What additional documentation may the Secretary require to resolve eligibility or payment issues?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false What additional documentation may the Secretary require to resolve eligibility or payment issues? 130.24 Section 130.24 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPASSIONATE PAYMENTS RICKY RAY HEMOPHILIA RELIEF FUND...

  19. Factors associated with intern noncompliance with the 2003 Accreditation Council for Graduate Medical Education's 30-hour duty period requirement.

    PubMed

    Maloney, Christopher G; Antommaria, Armand H Matheny; Bale, James F; Ying, Jian; Greene, Tom; Srivastava, Rajendu

    2012-07-13

    In 2003 the Accreditation Council for Graduate Medical Education mandated work hour restrictions. Violations can results in a residency program being cited or placed on probation. Recurrent violations could results in loss of accreditation. We wanted to determine specific intern and workload factors associated with violation of a specific mandate, the 30-hour duty period requirement. Retrospective review of interns' performance against the 30-hour duty period requirement during inpatient ward rotations at a pediatric residency program between June 24, 2008 and June 23, 2009. The analytical plan included both univariate and multivariable logistic regression analyses. Twenty of the 26 (77%) interns had 80 self-reported episodes of continuous work hours greater than 30 hours. In multivariable analysis, noncompliance was inversely associated with the number of prior inpatient rotations (odds ratio: 0.49, 95% confidence interval (0.38, 0.64) per rotation) but directly associated with the total number of patients (odds ratio: 1.30 (1.10, 1.53) per additional patient). The number of admissions on-call, number of admissions after midnight and number of discharges post-call were not significantly associated with noncompliance. The level of noncompliance also varied significantly between interns after accounting for intern experience and workload factors. Subject to limitations in statistical power, we were unable to identify specific intern characteristics, such as demographic variables or examination scores, which account for the variation in noncompliance between interns. Both intern and workload factors were associated with pediatric intern noncompliance with the 30-hour duty period requirement during inpatient ward rotations. Residency programs must develop information systems to understand the individual and experience factors associated with noncompliance and implement appropriate interventions to ensure compliance with the duty hour regulations.

  20. The GATA transcription factor gene gtaG is required for terminal differentiation in Dictyostelium

    PubMed Central

    2016-01-01

    ABSTRACT The GATA transcription factor GtaG is conserved in Dictyostelids and is essential for terminal differentiation in Dictyostelium discoideum, but its function is not well understood. Here, we show that gtaG is expressed in prestalk cells at the anterior region of fingers and in the extending stalk during culmination. The gtaG− phenotype is cell-autonomous in prestalk cells and non-cell-autonomous in prespore cells. Transcriptome analyses reveal that GtaG regulates prestalk gene expression during cell differentiation before culmination and is required for progression into culmination. GtaG-dependent genes include genetic suppressors of the Dd-STATa-defective phenotype (Dd-STATa is also known as DstA) as well as Dd-STATa target-genes, including extracellular matrix genes. We show that GtaG might be involved in the production of two culmination-signaling molecules, cyclic di-GMP (c-di-GMP) and the spore differentiation factor SDF-1, and that addition of c-di-GMP rescues the gtaG− culmination and spore formation deficiencies. We propose that GtaG is a regulator of terminal differentiation that functions in concert with Dd-STATa and controls culmination through regulating c-di-GMP and SDF-1 production in prestalk cells. PMID:26962009

  1. 45 CFR 1351.20 - What are the additional requirements under a Runaway and Homeless Youth Program grant?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false What are the additional requirements under a Runaway and Homeless Youth Program grant? 1351.20 Section 1351.20 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  2. 45 CFR 1351.20 - What are the additional requirements under a Runaway and Homeless Youth Program grant?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false What are the additional requirements under a Runaway and Homeless Youth Program grant? 1351.20 Section 1351.20 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  3. 45 CFR 1351.20 - What are the additional requirements under a Runaway and Homeless Youth Program grant?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false What are the additional requirements under a Runaway and Homeless Youth Program grant? 1351.20 Section 1351.20 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  4. 49 CFR 1155.23 - Additional requirements when filing after an unsatisfactory result from a State, local, or...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Procedures Governing Applications for a Land-Use-Exemption Permit § 1155.23 Additional requirements when... the facility. (a) When an applicant has previously sought permission from the applicable state, local... siting of the facility, the applicant may petition the Board to accept an application for a land-use...

  5. 45 CFR 260.55 - What are the additional requirements for Federal recognition of good cause domestic violence...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... recognition of good cause domestic violence waivers? 260.55 Section 260.55 Public Welfare Regulations Relating...) PROVISIONS What Special Provisions Apply to Victims of Domestic Violence? § 260.55 What are the additional requirements for Federal recognition of good cause domestic violence waivers? To be federally recognized, good...

  6. Factors determining insulin requirements in women with type 1 diabetes mellitus during pregnancy: a review

    PubMed Central

    McIntyre, Harold David; Callaway, Leonie

    2014-01-01

    Most women with type 1 diabetes mellitus (T1DM) have increased insulin requirements during pregnancy. However, a minority of women have a fall in insulin requirements. When this occurs in late gestation, it often provokes concern regarding possible compromise of the feto-placental unit. In some centres, this is considered as an indication for delivery, including premature delivery. There are, however, many other factors that affect insulin requirements in pregnancy in women with type 1 diabetes mellitus and the decline in insulin requirements may represent a variant of normal pregnancy. If there is no underlying pathological process, expedited delivery in these women is not warranted and confers increased risks to the newborn. We will explore the factors affecting insulin requirements in gestation in this review. We will also discuss some novel concepts regarding beta-cell function in pregnancy. PMID:27512424

  7. 41 CFR 102-83.30 - In addition to its mission and program requirements, are there any other issues that Federal...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... OF SPACE Location of Space Delineated Area § 102-83.30 In addition to its mission and program... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false In addition to its mission and program requirements, are there any other issues that Federal agencies must consider in...

  8. 41 CFR 102-83.30 - In addition to its mission and program requirements, are there any other issues that Federal...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OF SPACE Location of Space Delineated Area § 102-83.30 In addition to its mission and program... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false In addition to its mission and program requirements, are there any other issues that Federal agencies must consider in...

  9. 41 CFR 102-83.30 - In addition to its mission and program requirements, are there any other issues that Federal...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... OF SPACE Location of Space Delineated Area § 102-83.30 In addition to its mission and program... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false In addition to its mission and program requirements, are there any other issues that Federal agencies must consider in...

  10. 41 CFR 102-83.30 - In addition to its mission and program requirements, are there any other issues that Federal...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OF SPACE Location of Space Delineated Area § 102-83.30 In addition to its mission and program... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false In addition to its mission and program requirements, are there any other issues that Federal agencies must consider in...

  11. 48 CFR 7.108 - Additional requirements for telecommuting.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... for telecommuting. 7.108 Section 7.108 Federal Acquisition Regulations System FEDERAL ACQUISITION... telecommuting. In accordance with section 1428 of Public Law 108-136, an agency shall generally not discourage a... the agency, including security requirements, cannot be met if telecommuting is permitted. The...

  12. 45 CFR 260.55 - What are the additional requirements for Federal recognition of good cause domestic violence...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false What are the additional requirements for Federal recognition of good cause domestic violence waivers? 260.55 Section 260.55 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND...

  13. 30 CFR 250.803 - Additional production system requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... pressure vessels at any time when there is a change in operating pressures that requires new settings for... significant change in operating pressures. The most recent pressure-recorder charts used to determine... subfreezing climates, the lessee shall furnish evidence to the District Manager that the firefighting system...

  14. 30 CFR 250.803 - Additional production system requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... pressure vessels at any time when there is a change in operating pressures that requires new settings for... significant change in operating pressures. The most recent pressure-recorder charts used to determine... subfreezing climates, the lessee shall furnish evidence to the District Manager that the firefighting system...

  15. 30 CFR 250.803 - Additional production system requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... pressure vessels at any time when there is a change in operating pressures that requires new settings for... significant change in operating pressures. The most recent pressure-recorder charts used to determine... subfreezing climates, the lessee shall furnish evidence to the District Manager that the firefighting system...

  16. 48 CFR 27.406-2 - Additional data requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... solicitations and contracts involving experimental, developmental, research or demonstration work (other than basic or applied research to be performed under a contract solely by a university or college when the..., research, or demonstration contracts, it may not be feasible to ascertain all the data requirements at...

  17. Aeronautical Industry Requirements for Titanium Alloys

    NASA Astrophysics Data System (ADS)

    Bran, D. T.; Elefterie, C. F.; Ghiban, B.

    2017-06-01

    The project presents the requirements imposed for aviation components made from Titanium based alloys. A significant portion of the aircraft pylons are manufactured from Titanium alloys. Strength, weight, and reliability are the primary factors to consider in aircraft structures. These factors determine the requirements to be met by any material used to construct or repair the aircraft. Many forces and structural stresses act on an aircraft when it is flying and when it is static and this thesis describes environmental factors, conditions of external aggression, mechanical characteristics and loadings that must be satisfied simultaneously by a Ti-based alloy, compared to other classes of aviation alloys (as egg. Inconel super alloys, Aluminum alloys).For this alloy class, the requirements are regarding strength to weight ratio, reliability, corrosion resistance, thermal expansion and so on. These characteristics additionally continue to provide new opportunities for advanced manufacturing methods.

  18. Interstitial pneumonia with autoimmune features: an additional risk factor for ARDS?

    PubMed

    Grasselli, Giacomo; Vergnano, Beatrice; Pozzi, Maria Rosa; Sala, Vittoria; D'Andrea, Gabriele; Scaravilli, Vittorio; Mantero, Marco; Pesci, Alberto; Pesenti, Antonio

    2017-09-18

    Interstitial pneumonia with autoimmune features (IPAF) identifies a recently recognized autoimmune syndrome characterized by interstitial lung disease and autoantibodies positivity, but absence of a specific connective tissue disease diagnosis or alternative etiology. We retrospectively reviewed the clinical presentation, diagnostic workup and management of seven critically ill patients who met diagnostic criteria for IPAF. We compared baseline characteristics and clinical outcome of IPAF patients with those of the population of ARDS patients admitted in the same period. Seven consecutive patients with IPAF admitted to intensive care unit for acute respiratory distress syndrome (ARDS) were compared with 78 patients with ARDS secondary to a known risk factor and with eight ARDS patients without recognized risk factors. Five IPAF patients (71%) survived and were discharged alive from ICU: Their survival rate was equal to that of patients with a known risk factor (71%), while the subgroup of patients without risk factors had a markedly lower survival (38%). According to the Berlin definition criteria, ARDS was severe in four IPAF patients and moderate in the remaining three. All had multiple organ dysfunction at presentation. The most frequent autoantibody detected was anti-SSA/Ro52. All patients required prolonged mechanical ventilation (median duration 49 days, range 10-88); four received extracorporeal membrane oxygenation and one received low-flow extracorporeal CO 2 removal. All patients received immunosuppressive therapy. This is the first description of a cohort of critical patients meeting the diagnostic criteria for IPAF presenting with ARDS. This diagnosis should be considered in any critically ill patient with interstitial lung disease of unknown origin. While management is challenging and level of support high, survival appears to be good and comparable to that of patients with ARDS associated with a known clinical insult.

  19. 30 CFR 250.803 - Additional production system requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ranges of pressure vessels at any time when there is a change in operating pressures that requires new... significant change in operating pressures. The most recent pressure-recorder charts used to determine... prominent place on the facility or structure. (v) For operations in subfreezing climates, the lessee shall...

  20. Characterization of the host factors required for hepadnavirus covalently closed circular (ccc) DNA formation.

    PubMed

    Guo, Haitao; Xu, Chunxiao; Zhou, Tianlun; Block, Timothy M; Guo, Ju-Tao

    2012-01-01

    Synthesis of the covalently closed circular (ccc) DNA is a critical, but not well-understood step in the life cycle of hepadnaviruses. Our previous studies favor a model that removal of genome-linked viral DNA polymerase occurs in the cytoplasm and the resulting deproteinized relaxed circular DNA (DP-rcDNA) is subsequently transported into the nucleus and converted into cccDNA. In support of this model, our current study showed that deproteinization of viral double-stranded linear (dsl) DNA also took place in the cytoplasm. Furthermore, we demonstrated that Ku80, a component of non-homologous end joining DNA repair pathway, was essential for synthesis of cccDNA from dslDNA, but not rcDNA. In an attempt to identify additional host factors regulating cccDNA biosynthesis, we found that the DP-rcDNA was produced in all tested cell lines that supported DHBV DNA replication, but cccDNA was only synthesized in the cell lines that accumulated high levels of DP-rcDNA, except for NCI-H322M and MDBK cells, which failed to synthesize cccDNA despite of the existence of nuclear DP-rcDNA. The results thus imply that while removal of the genome-linked viral DNA polymerase is most likely catalyzed by viral or ubiquitous host function(s), nuclear factors required for the conversion of DP-rcDNA into cccDNA and/or its maintenance are deficient in the above two cell lines, which could be useful tools for identification of the elusive host factors essential for cccDNA biosynthesis or maintenance.

  1. 33 CFR 154.1125 - Additional response plan requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Sound: (A) Valdez; (B) Tatitlek; (C) Cordova; (D) Whittier; (E) Chenega; and (F) Fish hatcheries located...) Address the responsibilities required in § 154.1035(b)(3)(iii). (2) Exercises. Identification of exercise procedures that must— (i) Provide for two exercises of the oil spill removal organization each year that test...

  2. 48 CFR 27.406-2 - Additional data requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., research, or demonstration contracts, it may not be feasible to ascertain all the data requirements at... basic or applied research to be performed under a contract solely by a university or college when the... research to be performed by a university or college, and the contracting officer believes the contract...

  3. 48 CFR 27.406-2 - Additional data requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., research, or demonstration contracts, it may not be feasible to ascertain all the data requirements at... basic or applied research to be performed under a contract solely by a university or college when the... research to be performed by a university or college, and the contracting officer believes the contract...

  4. 21 CFR 1311.116 - Additional requirements for biometrics.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... biometric as described in § 1311.115, it must comply with the following requirements. (b) The biometric subsystem must operate at a false match rate of 0.001 or lower. (c) The biometric subsystem must use... paragraph (h) of this section. (d) The biometric subsystem must conform to Personal Identity Verification...

  5. 21 CFR 1311.116 - Additional requirements for biometrics.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... biometric as described in § 1311.115, it must comply with the following requirements. (b) The biometric subsystem must operate at a false match rate of 0.001 or lower. (c) The biometric subsystem must use... paragraph (h) of this section. (d) The biometric subsystem must conform to Personal Identity Verification...

  6. Factors associated with intern noncompliance with the 2003 Accreditation Council for Graduate Medical Education’s 30-hour duty period requirement

    PubMed Central

    2012-01-01

    Background In 2003 the Accreditation Council for Graduate Medical Education mandated work hour restrictions. Violations can results in a residency program being cited or placed on probation. Recurrent violations could results in loss of accreditation. We wanted to determine specific intern and workload factors associated with violation of a specific mandate, the 30-hour duty period requirement. Methods Retrospective review of interns’ performance against the 30-hour duty period requirement during inpatient ward rotations at a pediatric residency program between June 24, 2008 and June 23, 2009. The analytical plan included both univariate and multivariable logistic regression analyses. Results Twenty of the 26 (77%) interns had 80 self-reported episodes of continuous work hours greater than 30 hours. In multivariable analysis, noncompliance was inversely associated with the number of prior inpatient rotations (odds ratio: 0.49, 95% confidence interval (0.38, 0.64) per rotation) but directly associated with the total number of patients (odds ratio: 1.30 (1.10, 1.53) per additional patient). The number of admissions on-call, number of admissions after midnight and number of discharges post-call were not significantly associated with noncompliance. The level of noncompliance also varied significantly between interns after accounting for intern experience and workload factors. Subject to limitations in statistical power, we were unable to identify specific intern characteristics, such as demographic variables or examination scores, which account for the variation in noncompliance between interns. Conclusions Both intern and workload factors were associated with pediatric intern noncompliance with the 30-hour duty period requirement during inpatient ward rotations. Residency programs must develop information systems to understand the individual and experience factors associated with noncompliance and implement appropriate interventions to ensure compliance with the

  7. 34 CFR 658.34 - What additional factors does the Secretary consider in selecting grant recipients?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What additional factors does the Secretary consider in selecting grant recipients? 658.34 Section 658.34 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION UNDERGRADUATE INTERNATIONAL...

  8. Regulation of Fuel and Fuel Additives: Refiner and Importer Quality Assurance Requirements for Downstream Oxygenate Blending and Requirements for Disposition of Pipeline Interfaces Additional Resources

    EPA Pesticide Factsheets

    EPA has published a Direct Final Rule that addresses requirements for parties that handle pipeline interface as well as addresses downstream quality assurance requirements for refiners (EPA publication # EPA-420-F-06-039).

  9. 77 FR 24628 - World Trade Center Health Program Requirements for the Addition of New WTC-Related Health Conditions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... World Trade Center Health Program Requirements for the Addition of New WTC-Related Health Conditions...) to establish the World Trade Center (WTC) Health Program. Sections 3311, 3312, and 3321 of Title..., 2012. FOR FURTHER INFORMATION CONTACT: Roy M. Fleming, Sc.D., Senior Science Advisor, World Trade...

  10. Minimum requirements for the function of eukaryotic translation initiation factor 2.

    PubMed Central

    Erickson, F L; Nika, J; Rippel, S; Hannig, E M

    2001-01-01

    Eukaryotic translation initiation factor 2 (eIF2) is a G protein heterotrimer required for GTP-dependent delivery of initiator tRNA to the ribosome. eIF2B, the nucleotide exchange factor for eIF2, is a heteropentamer that, in yeast, is encoded by four essential genes and one nonessential gene. We found that increased levels of wild-type eIF2, in the presence of sufficient levels of initiator tRNA, overcome the requirement for eIF2B in vivo. Consistent with bypassing eIF2B, these conditions also suppress the lethal effect of overexpressing the mammalian tumor suppressor PKR, an eIF2alpha kinase. The effects described are further enhanced in the presence of a mutation in the G protein (gamma) subunit of eIF2, gcd11-K250R, which mimics the function of eIF2B in vitro. Interestingly, the same conditions that bypass eIF2B also overcome the requirement for the normally essential eIF2alpha structural gene (SUI2). Our results suggest that the eIF2betagamma complex is capable of carrying out the essential function(s) of eIF2 in the absence of eIF2alpha and eIF2B and are consistent with the idea that the latter function primarily to regulate the level of eIF2.GTP.Met-tRNA(i)(Met) ternary complexes in vivo. PMID:11333223

  11. 33 CFR 148.107 - What additional information may be required?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: GENERAL Application for a License § 148.107...), in coordination with MARAD, may determine whether compliance with the requirement is important to processing the application within the time prescribed by the Act. (3) If the requirement is important to...

  12. Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection.

    PubMed

    Costello, Patrick S; Nicolas, Robert H; Watanabe, Yasuyuki; Rosewell, Ian; Treisman, Richard

    2004-03-01

    Thymocyte selection and differentiation requires extracellular signal-regulated kinase (Erk) signaling, but transcription factor substrates of Erk in thymocytes are unknown. We have characterized the function of SAP-1 (Elk4), an Erk-regulated transcription factor, in thymocyte development. Early thymocyte development was normal, but single-positive thymocyte and peripheral T cell numbers were reduced, reflecting a T cell-autonomous defect. T cell receptor-induced activation of SAP-1 target genes such as Egr1 was substantially impaired in double-positive thymocytes, although Erk activation was normal. Analysis of T cell receptor transgenes showed that positive selection was reduced by 80-90% in SAP-1-deficient mice; heterozygous mice showed a moderate defect. Negative selection was unimpaired. SAP-1 thus directly links Erk signaling to the transcriptional events required for thymocyte positive selection.

  13. 40 CFR 80.1363 - What are the additional requirements under this subpart for gasoline produced at foreign refineries?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 17 2014-07-01 2014-07-01 false What are the additional requirements... January 1, 2004 through December 31, 2005, and any work papers related to refinery baseline establishment... this subpart, including conduct that violates the False Statements Accountability Act of 1996 (18 U.S.C...

  14. 40 CFR 80.1363 - What are the additional requirements under this subpart for gasoline produced at foreign refineries?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 17 2012-07-01 2012-07-01 false What are the additional requirements... January 1, 2004 through December 31, 2005, and any work papers related to refinery baseline establishment... this subpart, including conduct that violates the False Statements Accountability Act of 1996 (18 U.S.C...

  15. 40 CFR 80.1363 - What are the additional requirements under this subpart for gasoline produced at foreign refineries?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 16 2011-07-01 2011-07-01 false What are the additional requirements... January 1, 2004 through December 31, 2005, and any work papers related to refinery baseline establishment... this subpart, including conduct that violates the False Statements Accountability Act of 1996 (18 U.S.C...

  16. 40 CFR 80.1363 - What are the additional requirements under this subpart for gasoline produced at foreign refineries?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false What are the additional requirements... January 1, 2004 through December 31, 2005, and any work papers related to refinery baseline establishment... this subpart, including conduct that violates the False Statements Accountability Act of 1996 (18 U.S.C...

  17. 40 CFR 80.1363 - What are the additional requirements under this subpart for gasoline produced at foreign refineries?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false What are the additional requirements... January 1, 2004 through December 31, 2005, and any work papers related to refinery baseline establishment... this subpart, including conduct that violates the False Statements Accountability Act of 1996 (18 U.S.C...

  18. 40 CFR 60.5411 - What additional requirements must I meet to determine initial compliance for my closed vent...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 7 2013-07-01 2013-07-01 false What additional requirements must I meet to determine initial compliance for my closed vent systems routing materials from storage vessels and centrifugal compressor wet seal degassing systems? 60.5411 Section 60.5411 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED)...

  19. 49 CFR 173.302b - Additional requirements for shipment of non-liquefied (permanent) compressed gases in UN pressure...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Additional requirements for shipment of non-liquefied (permanent) compressed gases in UN pressure receptacles. 173.302b Section 173.302b Transportation... cylinder. The use of UN tubes and MEGCs is not authorized. (e) Carbon monoxide, compressed UN 1016. Carbon...

  20. 49 CFR 173.302b - Additional requirements for shipment of non-liquefied (permanent) compressed gases in UN pressure...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Additional requirements for shipment of non-liquefied (permanent) compressed gases in UN pressure receptacles. 173.302b Section 173.302b Transportation... cylinder. The use of UN tubes and MEGCs is not authorized. (e) Carbon monoxide, compressed UN 1016. Carbon...

  1. 42 CFR 412.29 - Excluded rehabilitation units: Additional requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Costs and Inpatient Capital-Related Costs § 412.29 Excluded rehabilitation units: Additional..., social services, psychological services (including neuropsychological services), and orthotic and...

  2. An interbacterial NAD(P) + glycohydrolase toxin requires elongation factor Tu for delivery to target cells

    DOE PAGES

    Whitney, John C.; Quentin, Dennis; Sawai, Shin; ...

    2015-10-08

    Type VI secretion (T6S) influences the composition of microbial communities by catalyzing the delivery of toxins between adjacent bacterial cells. Here, we demonstrate that a T6S integral membrane toxin from Pseudomonas aeruginosa, Tse6, acts on target cells by degrading the universally essential dinucleotides NAD + and NADP +. Structural analyses of Tse6 show that it resembles mono-ADP-ribosyltransferase proteins, such as diphtheria toxin, with the exception of a unique loop that both excludes proteinaceous ADP-ribose acceptors and contributes to hydrolysis. We find that entry of Tse6 into target cells requires its binding to an essential housekeeping protein, translation elongation factor Tumore » (EF-Tu). These proteins participate in a larger assembly that additionally directs toxin export and provides chaperone activity. Lastly, visualization of this complex by electron microscopy defines the architecture of a toxin-loaded T6S apparatus and provides mechanistic insight into intercellular membrane protein delivery between bacteria.« less

  3. An Interbacterial NAD(P)+ Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Whitney, John C.; Quentin, Dennis; Sawai, Shin

    2015-10-08

    Type VI secretion (T6S) influences the composition of microbial communities by catalyzing the delivery of toxins between adjacent bacterial cells. Here, we demonstrate that a T6S integral membrane toxin from Pseudomonas aeruginosa, Tse6, acts on target cells by degrading the universally essential dinucleotides NAD + and NADP +. Structural analyses of Tse6 show that it resembles mono-ADP-ribosyltransferase proteins, such as diphtheria toxin, with the exception of a unique loop that both excludes proteinaceous ADP-ribose acceptors and contributes to hydrolysis. We find that entry of Tse6 into target cells requires its binding to an essential housekeeping protein, translation elongation factor Tumore » (EF-Tu). These proteins participate in a larger assembly that additionally directs toxin export and provides chaperone activity. Visualization of this complex by electron microscopy defines the architecture of a toxin-loaded T6S apparatus and provides mechanistic insight into intercellular membrane protein delivery between bacteria.« less

  4. Kruppel-like factor 15 is required for the cardiac adaptive response to fasting.

    PubMed

    Sugi, Keiki; Hsieh, Paishiun N; Ilkayeva, Olga; Shelkay, Shamanthika; Moroney, Bridget; Baadh, Palvir; Haynes, Browning; Pophal, Megan; Fan, Liyan; Newgard, Christopher B; Prosdocimo, Domenick A; Jain, Mukesh K

    2018-01-01

    Cardiac metabolism is highly adaptive in response to changes in substrate availability, as occur during fasting. This metabolic flexibility is essential to the maintenance of contractile function and is under the control of a group of select transcriptional regulators, notably the nuclear receptor family of factors member PPARα. However, the diversity of physiologic and pathologic states through which the heart must sustain function suggests the possible existence of additional transcriptional regulators that play a role in matching cardiac metabolism to energetic demand. Here we show that cardiac KLF15 is required for the normal cardiac response to fasting. Specifically, we find that cardiac function is impaired upon fasting in systemic and cardiac specific Klf15-null mice. Further, cardiac specific Klf15-null mice display a fasting-dependent accumulation of long chain acylcarnitine species along with a decrease in expression of the carnitine translocase Slc25a20. Treatment with a diet high in short chain fatty acids relieves the KLF15-dependent long chain acylcarnitine accumulation and impaired cardiac function in response to fasting. Our observations establish KLF15 as a critical mediator of the cardiac adaptive response to fasting through its regulation of myocardial lipid utilization.

  5. Requirements of titanium alloys for aeronautical industry

    NASA Astrophysics Data System (ADS)

    Ghiban, Brânduşa; Bran, Dragoş-Teodor; Elefterie, Cornelia Florina

    2018-02-01

    The project presents the requirements imposed for aeronatical components made from Titanium based alloys. Asignificant portion of the aircraft pylons are manufactured from Titanium alloys. Strength, weight, and reliability are the primary factors to consider in aircraft structures. These factors determine the requirements to be met by any material used to construct or repair the aircraft. Many forces and structural stresses act on an aircraft when it is flying and when it is static and this thesis describes environmental factors, conditions of external aggression, mechanical characteristics and loadings that must be satisfied simultaneously by a Ti-based alloy, compared to other classes of aviation alloys (as egg. Inconel super alloys, Aluminum alloys). For this alloy class, the requirements are regarding strength to weight ratio, reliability, corrosion resistance, thermal expansion and so on. These characteristics additionally continue to provide new opportunities for advanced manufacturing methods.

  6. A Human Factors Analysis of EVA Time Requirements

    NASA Technical Reports Server (NTRS)

    Pate, Dennis W.

    1997-01-01

    Human Factors Engineering (HFE) is a discipline whose goal is to engineer a safer, more efficient interface between humans and machines. HFE makes use of a wide range of tools and techniques to fulfill this goal. One of these tools is known as motion and time study, a technique used to develop time standards for given tasks. During the summer of 1995, a human factors motion and time study was initiated with the goals of developing a database of EVA task times and developing a method of utilizing the database to predict how long an EVA should take. Initial development relied on the EVA activities performed during the STS-61 (Hubble) mission. The first step of the study was to become familiar with EVA's, the previous task-time studies, and documents produced on EVA's. After reviewing these documents, an initial set of task primitives and task-time modifiers was developed. Data was collected from videotaped footage of two entire STS-61 EVA missions and portions of several others, each with two EVA astronauts. Feedback from the analysis of the data was used to further refine the primitives and modifiers used. The project was continued during the summer of 1996, during which data on human errors was also collected and analyzed. Additional data from the STS-71 mission was also collected. Analysis of variance techniques for categorical data was used to determine which factors may affect the primitive times and how much of an effect they have. Probability distributions for the various task were also generated. Further analysis of the modifiers and interactions is planned.

  7. Consolidation & Factors Influencing Sintering Process in Polymer Powder Based Additive Manufacturing

    NASA Astrophysics Data System (ADS)

    Sagar, M. B.; Elangovan, K.

    2017-08-01

    Additive Manufacturing (AM) is two decade old technology; where parts are build layer manufacturing method directly from a CAD template. Over the years, AM techniques changes the future way of part fabrication with enhanced intricacy and custom-made features are aimed. Commercially polymers, metals, ceramic and metal-polymer composites are in practice where polymers enhanced the expectations in AM and are considered as a kind of next industrial revolution. Growing trend in polymer application motivated to study their feasibility and properties. Laser sintering, Heat sintering and Inhibition sintering are the most successful AM techniques for polymers but having least application. The presentation gives up selective sintering of powder polymers and listed commercially available polymer materials. Important significant factors for effective processing and analytical approaches to access them are discussed.

  8. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors required during Trypanosoma cruzi parasitophorous vacuole development.

    PubMed

    Cueto, Juan Agustín; Vanrell, María Cristina; Salassa, Betiana Nebaí; Nola, Sébastien; Galli, Thierry; Colombo, María Isabel; Romano, Patricia Silvia

    2017-06-01

    Trypanosoma cruzi, the etiologic agent of Chagas disease, is an obligate intracellular parasite that exploits different host vesicular pathways to invade the target cells. Vesicular and target soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are key proteins of the intracellular membrane fusion machinery. During the early times of T. cruzi infection, several vesicles are attracted to the parasite contact sites in the plasma membrane. Fusion of these vesicles promotes the formation of the parasitic vacuole and parasite entry. In this work, we study the requirement and the nature of SNAREs involved in the fusion events that take place during T. cruzi infection. Our results show that inhibition of N-ethylmaleimide-sensitive factor protein, a protein required for SNARE complex disassembly, impairs T. cruzi infection. Both TI-VAMP/VAMP7 and cellubrevin/VAMP3, two v-SNAREs of the endocytic and exocytic pathways, are specifically recruited to the parasitophorous vacuole membrane in a synchronized manner but, although VAMP3 is acquired earlier than VAMP7, impairment of VAMP3 by tetanus neurotoxin fails to reduce T. cruzi infection. In contrast, reduction of VAMP7 activity by expression of VAMP7's longin domain, depletion by small interfering RNA or knockout, significantly decreases T. cruzi infection susceptibility as a result of a minor acquisition of lysosomal components to the parasitic vacuole. In addition, overexpression of the VAMP7 partner Vti1b increases the infection, whereas expression of a KIF5 kinesin mutant reduces VAMP7 recruitment to vacuole and, concomitantly, T. cruzi infection. Altogether, these data support a key role of TI-VAMP/VAMP7 in the fusion events that culminate in the T. cruzi parasitophorous vacuole development. © 2016 John Wiley & Sons Ltd.

  9. Success rates of single-dose methotrexate and additional dose requirements among women with first and previous ectopic pregnancies.

    PubMed

    Cirik, Derya Akdag; Kinay, Tugba; Keskin, Ugur; Ozden, Eda; Altay, Metin; Gelisen, Orhan

    2016-04-01

    To compare the success of the single-dose methotrexate regimen and the requirement for a second or third dose of methotrexate between women with their first ectopic pregnancy (EP) and those with previous EP. In a retrospective cohort study, data were analyzed from women treated for EP by single-dose methotrexate at a Turkish tertiary referral center between January 2010 and December 2013. Data were compared between women with at least one previous EP and those with their first EP. The success rate of the protocol in the first and previous EP groups was similar: 93.0% (320/344) and 87.3% (48/55), respectively. History of previous EP was not a predictor of treatment failure. However, the requirement for additional methotrexate doses was significantly higher in the previous EP group (16/48 [33.4%]) than in the first EP group (55/320 [17.2%]; P=0.03). Multivariate analysis showed that history of tubal surgery (P=0.006) and initial levels of the β-subunit of human chorionic gonadotropin (P=0.001) were significant predictors of treatment failure. Although the single-dose regimen had similar success rates in the previous EP and first EP groups, additional doses of methotrexate were more frequently required in the previous EP group. Copyright © 2015 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

  10. Productive replication of human papillomavirus 31 requires DNA repair factor Nbs1.

    PubMed

    Anacker, Daniel C; Gautam, Dipendra; Gillespie, Kenric A; Chappell, William H; Moody, Cary A

    2014-08-01

    Activation of the ATM (ataxia telangiectasia-mutated kinase)-dependent DNA damage response (DDR) is necessary for productive replication of human papillomavirus 31 (HPV31). We previously found that DNA repair and homologous recombination (HR) factors localize to sites of HPV replication, suggesting that ATM activity is required to recruit factors to viral genomes that can productively replicate viral DNA in a recombination-dependent manner. The Mre11-Rad50-Nbs1 (MRN) complex is an essential component of the DDR that is necessary for ATM-mediated HR repair and localizes to HPV DNA foci. In this study, we demonstrate that the HPV E7 protein is sufficient to increase levels of the MRN complex and also interacts with MRN components. We have found that Nbs1 depletion blocks productive viral replication and results in decreased localization of Mre11, Rad50, and the principal HR factor Rad51 to HPV DNA foci upon differentiation. Nbs1 contributes to the DDR by acting as an upstream activator of ATM in response to double-strand DNA breaks (DSBs) and as a downstream effector of ATM activity in the intra-S-phase checkpoint. We have found that phosphorylation of ATM and its downstream target Chk2, as well as SMC1 (structural maintenance of chromosome 1), is maintained upon Nbs1 knockdown in differentiating cells. Given that ATM and Chk2 are required for productive replication, our results suggest that Nbs1 contributes to viral replication outside its role as an ATM activator, potentially through ensuring localization of DNA repair factors to viral genomes that are necessary for efficient productive replication. The mechanisms that regulate human papillomavirus (HPV) replication during the viral life cycle are not well understood. Our finding that Nbs1 is necessary for productive replication even in the presence of ATM (ataxia telangiectasia-mutated kinase) and Chk2 phosphorylation offers evidence that Nbs1 contributes to viral replication downstream of facilitating ATM

  11. Productive Replication of Human Papillomavirus 31 Requires DNA Repair Factor Nbs1

    PubMed Central

    Anacker, Daniel C.; Gautam, Dipendra; Gillespie, Kenric A.; Chappell, William H.

    2014-01-01

    ABSTRACT Activation of the ATM (ataxia telangiectasia-mutated kinase)-dependent DNA damage response (DDR) is necessary for productive replication of human papillomavirus 31 (HPV31). We previously found that DNA repair and homologous recombination (HR) factors localize to sites of HPV replication, suggesting that ATM activity is required to recruit factors to viral genomes that can productively replicate viral DNA in a recombination-dependent manner. The Mre11-Rad50-Nbs1 (MRN) complex is an essential component of the DDR that is necessary for ATM-mediated HR repair and localizes to HPV DNA foci. In this study, we demonstrate that the HPV E7 protein is sufficient to increase levels of the MRN complex and also interacts with MRN components. We have found that Nbs1 depletion blocks productive viral replication and results in decreased localization of Mre11, Rad50, and the principal HR factor Rad51 to HPV DNA foci upon differentiation. Nbs1 contributes to the DDR by acting as an upstream activator of ATM in response to double-strand DNA breaks (DSBs) and as a downstream effector of ATM activity in the intra-S-phase checkpoint. We have found that phosphorylation of ATM and its downstream target Chk2, as well as SMC1 (structural maintenance of chromosome 1), is maintained upon Nbs1 knockdown in differentiating cells. Given that ATM and Chk2 are required for productive replication, our results suggest that Nbs1 contributes to viral replication outside its role as an ATM activator, potentially through ensuring localization of DNA repair factors to viral genomes that are necessary for efficient productive replication. IMPORTANCE The mechanisms that regulate human papillomavirus (HPV) replication during the viral life cycle are not well understood. Our finding that Nbs1 is necessary for productive replication even in the presence of ATM (ataxia telangiectasia-mutated kinase) and Chk2 phosphorylation offers evidence that Nbs1 contributes to viral replication downstream of

  12. The Selenocysteine-Specific Elongation Factor Contains Unique Sequences That Are Required for Both Nuclear Export and Selenocysteine Incorporation.

    PubMed

    Dubey, Aditi; Copeland, Paul R

    2016-01-01

    Selenocysteine (Sec) is a critical residue in at least 25 human proteins that are essential for antioxidant defense and redox signaling in cells. Sec is inserted into proteins cotranslationally by the recoding of an in-frame UGA termination codon to a Sec codon. In eukaryotes, this recoding event requires several specialized factors, including a dedicated, Sec-specific elongation factor called eEFSec, which binds Sec-tRNASec with high specificity and delivers it to the ribosome for selenoprotein production. Unlike most translation factors, including the canonical elongation factor eEF1A, eEFSec readily localizes to the nucleus of mammalian cells and shuttles between the cytoplasmic and nuclear compartments. The functional significance of eEFSec's nuclear localization has remained unclear. In this study, we have examined the subcellular localization of eEFSec in the context of altered Sec incorporation to demonstrate that reduced selenoprotein production does not correlate with changes in the nuclear localization of eEFSec. In addition, we identify several novel sequences of the protein that are essential for localization as well as Sec insertion activity, and show that eEFSec utilizes CRM1-mediated nuclear export pathway. Our findings argue for two distinct pools of eEFSec in the cell, where the cytoplasmic pool participates in Sec incorporation and the nuclear pool may be involved in an as yet unknown function.

  13. 23 CFR Appendix C to Subpart B of... - Additional Required Contract Provisions, Appalachian Development Highway System and Local Access...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Additional Required Contract Provisions, Appalachian Development Highway System and Local Access Roads Contracts Other Than Construction Contracts C Appendix C to..., Appalachian Development Highway System and Local Access Roads Contracts Other Than Construction Contracts...

  14. Risk factors for drainage-requiring ascites after refractory peritonitis in peritoneal dialysis patients.

    PubMed

    Lee, Cheng-Chia; Tu, Kun-Hua; Chen, Hsiao-Hui; Chang, Ming-Yang; Hung, Cheng-Chieh

    2016-10-01

    Refractory peritonitis remains a thorny issue for patients with chronic peritoneal dialysis (PD). Shortly after catheter removal, some patients develop persistent peritoneal inflammation and ascites formation, which require percutaneous drainage for symptom relief. Our study aimed at finding the risk factors for this kind of event. A total of 47 PD patients complicated with refractory peritonitis who underwent catheter removal between January 2009 and December 2011 were enrolled in this study. Data were compared between patients with and without the development of symptomatic ascites requiring drainage during hospitalization. Among the 47 refractory peritonitis patients, 15 patients developed symptomatic ascites that needed further drainage shortly after catheter removal during hospitalization. The following factors were associated with an increased risk: longer dialysis duration, higher peritoneal Kt/V urea, and a significant rise in serum C-reactive protein (CRP) level after catheter removal. These patients had a prolonged hospital stay (62 vs 21 days, P < 0.001) and a significantly higher risk of recurrent loculated ascites during subsequent 6 months of follow-up (33.3 vs 6.2 %, P = 0.022) compared with patients who did not develop ascites requiring drainage during hospitalization. A significant portion of patients with refractory PD peritonitis experienced ascites requiring drainage shortly after catheter removal, which led to a prolonged hospitalization. Whether routine drain placement at the time of catheter removal for this high-risk group would be of benefit warrants further prospective studies.

  15. Design of admission medication reconciliation technology: a human factors approach to requirements and prototyping.

    PubMed

    Lesselroth, Blake J; Adams, Kathleen; Tallett, Stephanie; Wood, Scott D; Keeling, Amy; Cheng, Karen; Church, Victoria L; Felder, Robert; Tran, Hanna

    2013-01-01

    Our objectives were to (1) develop an in-depth understanding of the workflow and information flow in medication reconciliation, and (2) design medication reconciliation support technology using a combination of rapid-cycle prototyping and human-centered design. Although medication reconciliation is a national patient safety goal, limitations both of physical environment and in workflow can make it challenging to implement durable systems. We used several human factors techniques to gather requirements and develop a new process to collect a medication history at hospital admission. We completed an ethnography and time and motion analysis of pharmacists in order to illustrate the processes used to reconcile medications. We then used the requirements to design prototype multimedia software for collecting a bedside medication history. We observed how pharmacists incorporated the technology into their physical environment and documented usability issues. Admissions occurred in three phases: (1) list compilation, (2) order processing, and (3) team coordination. Current medication reconciliation processes at the hospital average 19 minutes to complete and do not include a bedside interview. Use of our technology during a bedside interview required an average of 29 minutes. The software represents a viable proof-of-concept to automate parts of history collection and enhance patient communication. However, we discovered several usability issues that require attention. We designed a patient-centered technology to enhance how clinicians collect a patient's medication history. By using multiple human factors methods, our research team identified system themes and design constraints that influence the quality of the medication reconciliation process and implementation effectiveness of new technology. Evidence-based design, human factors, patient-centered care, safety, technology.

  16. 46 CFR 160.151-17 - Additional requirements for design and performance of SOLAS A and SOLAS B inflatable liferafts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 6 2011-10-01 2011-10-01 false Additional requirements for design and performance of SOLAS A and SOLAS B inflatable liferafts. 160.151-17 Section 160.151-17 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Inflatable Liferafts ...

  17. 48 CFR 301.603-73 - Additional HHS training requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... electives for the purpose of satisfying FAC-C requirements or as continuous learning for maintenance of FAC... each be 8 hours or more in length. (b) Performance based acquisition training. Effective January 1...-Based Acquisition (PBA) course prior to assuming such responsibilities. Refresher training in PBA is...

  18. 48 CFR 301.603-73 - Additional HHS training requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... electives for the purpose of satisfying FAC-C requirements or as continuous learning for maintenance of FAC-C or SAC certifications. (a) Earned value management training. Effective January 1, 2010, all... each be 8 hours or more in length. (b) Performance based acquisition training. Effective January 1...

  19. 48 CFR 301.603-73 - Additional HHS training requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... electives for the purpose of satisfying FAC-C requirements or as continuous learning for maintenance of FAC-C or SAC certifications. (a) Earned value management training. Effective January 1, 2010, all... each be 8 hours or more in length. (b) Performance based acquisition training. Effective January 1...

  20. 48 CFR 301.603-73 - Additional HHS training requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... electives for the purpose of satisfying FAC-C requirements or as continuous learning for maintenance of FAC-C or SAC certifications. (a) Earned value management training. Effective January 1, 2010, all... each be 8 hours or more in length. (b) Performance based acquisition training. Effective January 1...

  1. 48 CFR 301.603-73 - Additional HHS training requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... electives for the purpose of satisfying FAC-C requirements or as continuous learning for maintenance of FAC-C or SAC certifications. (a) Earned value management training. Effective January 1, 2010, all... each be 8 hours or more in length. (b) Performance based acquisition training. Effective January 1...

  2. 17 CFR 230.408 - Additional information.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Additional information. 230... RULES AND REGULATIONS, SECURITIES ACT OF 1933 General Requirements § 230.408 Additional information. (a) In addition to the information expressly required to be included in a registration statement, there...

  3. Chemoselective reductive nucleophilic addition to tertiary amides, secondary amides, and N-methoxyamides.

    PubMed

    Nakajima, Minami; Oda, Yukiko; Wada, Takamasa; Minamikawa, Ryo; Shirokane, Kenji; Sato, Takaaki; Chida, Noritaka

    2014-12-22

    As the complexity of targeted molecules increases in modern organic synthesis, chemoselectivity is recognized as an important factor in the development of new methodologies. Chemoselective nucleophilic addition to amide carbonyl centers is a challenge because classical methods require harsh reaction conditions to overcome the poor electrophilicity of the amide carbonyl group. We have successfully developed a reductive nucleophilic addition of mild nucleophiles to tertiary amides, secondary amides, and N-methoxyamides that uses the Schwartz reagent [Cp2 ZrHCl]. The reaction took place in a highly chemoselective fashion in the presence of a variety of sensitive functional groups, such as methyl esters, which conventionally require protection prior to nucleophilic addition. The reaction will be applicable to the concise synthesis of complex natural alkaloids from readily available amide groups. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Two distinct factors are required for induction of T-cell growth.

    PubMed

    Larsson, E L; Iscove, N N; Coutinho, A

    1980-02-14

    The molecular and cellular basis of T-lymphocyte activation remains a central question in immunology. The growth of already proliferating T cells is known to depend on T-cell growth factor (TCGF), a physiological mitogen. Noncycling T lymphocytes, however, are not sensitive to TCGF. They require a short contact with mitogenic lectins, such as concanavalin A (Con A) or leukoagglutinin to bind and respond to TCGF, and will thereafter maintain exponential growth for long periods provided that TCGF is not limiting. While the induction of TCGF reactivity results from the direct contact of Con A with resting T cells, the lectin-dependent production of TCGF is known to involve two cell types, both present in mouse spleen. One consists of I-A-negative cells, most of which are Thy-1-positive T lymphocytes, and the other consists of I-A-positive, immunoglobulin-negative, Thy-1-negative cells, most of which are macrophages. The nature of the respective contributions of the two cell types, and in particular the cellular origin of TCGF, has not yet been established. We have now established the I-A-negative population as the source of TCGF and show here that macrophages are required to supply a 20,000-molecular weight factor, chemically and functionally distinct from TCGF, which supports the production of TCGF by the I-A-negative cells.

  5. 40 CFR 60.5411 - What additional requirements must I meet to determine initial compliance for my covers and closed...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 7 2014-07-01 2014-07-01 false What additional requirements must I meet to determine initial compliance for my covers and closed vent systems routing materials from storage vessels and centrifugal compressor wet seal degassing systems? 60.5411 Section 60.5411 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY ...

  6. 23 CFR Appendix C to Subpart B of... - Additional Required Contract Provisions, Appalachian Development Highway System and Local Access...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Development Highway System and Local Access Roads Contracts Other Than Construction Contracts C Appendix C to.... 633, Subpt. B, App. C Appendix C to Subpart B of Part 633—Additional Required Contract Provisions.... Compliance with regulations. The contractor will comply with the provisions of 23 U.S.C. 324 and with the...

  7. 77 FR 59878 - Additional Requirements for Charitable Hospitals; Hearing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... public hearing is being held in the IRS Auditorium, Internal Revenue Service Building, 1111 Constitution... Constitution Avenue entrance. In addition, all visitors must present photo identification to enter the building... Constitution Avenue NW., Washington, DC or sent electronically via the Federal eRulemaking Portal at www...

  8. High pulmonary vascular resistance in addition to low right ventricular stroke work index effectively predicts biventricular assist device requirement.

    PubMed

    Imamura, Teruhiko; Kinugawa, Koichiro; Kinoshita, Osamu; Nawata, Kan; Ono, Minoru

    2016-03-01

    Although the right ventricular stroke work index (RVSWI) is a good index for RV function, a low RVSWI is not necessarily an indicator for the need for a right ventricular assist device at the time of left VAD implantation. We here aimed to determine a more precise indicator for the need for a biventricular assist device (BiVAD). In total, 116 patients (mean age, 38 ± 14 years), who underwent hemodynamic assessments preoperatively including 12 BiVAD patients, and had been followed at our institute from 2003 to 2015, were included. Multivariate logistic regression analysis indicated that RVSWI and pulmonary vascular resistance (PVR) were independent predictors of BiVAD requirement (P < 0.05 for both). In addition, all patients were classified into 4 groups: (1) normal (RVSWI > 5 g/m, PVR < 3.7 WU), (2) pulmonary hypertension (RVSWI > 5, PVR > 3.7), (3) RV failure (RVSWI < 5, PVR < 3.7), and (4) both pulmonary hypertension and RV failure (RVSWI < 5, PVR > 3.7), and examined. Most of the patients in Group 4 (75 %), with acutely depressed hemodynamics and inflammatory responses in the myocardium, required BiVAD. Overall, patients with BiVAD had a worse survival rate as compared with those with LVAD alone. In conclusion, high PVR in addition to low RVSWI effectively predicts BiVAD requirement.

  9. Three WRKY transcription factors additively repress abscisic acid and gibberellin signaling in aleurone cells.

    PubMed

    Zhang, Liyuan; Gu, Lingkun; Ringler, Patricia; Smith, Stanley; Rushton, Paul J; Shen, Qingxi J

    2015-07-01

    Members of the WRKY transcription factor superfamily are essential for the regulation of many plant pathways. Functional redundancy due to duplications of WRKY transcription factors, however, complicates genetic analysis by allowing single-mutant plants to maintain wild-type phenotypes. Our analyses indicate that three group I WRKY genes, OsWRKY24, -53, and -70, act in a partially redundant manner. All three showed characteristics of typical WRKY transcription factors: each localized to nuclei and yeast one-hybrid assays indicated that they all bind to W-boxes, including those present in their own promoters. Quantitative real time-PCR (qRT-PCR) analyses indicated that the expression levels of the three WRKY genes varied in the different tissues tested. Particle bombardment-mediated transient expression analyses indicated that all three genes repress the GA and ABA signaling in a dosage-dependent manner. Combination of all three WRKY genes showed additive antagonism of ABA and GA signaling. These results suggest that these WRKY proteins function as negative transcriptional regulators of GA and ABA signaling. However, different combinations of these WRKY genes can lead to varied strengths in suppression of their targets. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  10. 25 CFR 39.1101 - Addition of pre-kindergarten as a weight factor to the Indian School Equalization Formula in...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Addition of pre-kindergarten as a weight factor to the Indian School Equalization Formula in fiscal year 1982. 39.1101 Section 39.1101 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION THE INDIAN SCHOOL EQUALIZATION PROGRAM Pre-kindergarten Programs § 39.1101 Addition of...

  11. 25 CFR 39.1101 - Addition of pre-kindergarten as a weight factor to the Indian School Equalization Formula in...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Addition of pre-kindergarten as a weight factor to the Indian School Equalization Formula in fiscal year 1982. 39.1101 Section 39.1101 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION THE INDIAN SCHOOL EQUALIZATION PROGRAM Pre-kindergarten Programs § 39.1101 Addition of...

  12. 25 CFR 39.1101 - Addition of pre-kindergarten as a weight factor to the Indian School Equalization Formula in...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Addition of pre-kindergarten as a weight factor to the Indian School Equalization Formula in fiscal year 1982. 39.1101 Section 39.1101 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION THE INDIAN SCHOOL EQUALIZATION PROGRAM Pre-kindergarten Programs § 39.1101 Addition of...

  13. 25 CFR 39.1101 - Addition of pre-kindergarten as a weight factor to the Indian School Equalization Formula in...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Addition of pre-kindergarten as a weight factor to the Indian School Equalization Formula in fiscal year 1982. 39.1101 Section 39.1101 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION THE INDIAN SCHOOL EQUALIZATION PROGRAM Pre-kindergarten Programs § 39.1101 Addition of...

  14. 25 CFR 39.1101 - Addition of pre-kindergarten as a weight factor to the Indian School Equalization Formula in...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Addition of pre-kindergarten as a weight factor to the Indian School Equalization Formula in fiscal year 1982. 39.1101 Section 39.1101 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION THE INDIAN SCHOOL EQUALIZATION PROGRAM Pre-kindergarten Programs § 39.1101 Addition of...

  15. Lifestyle Factors in Late Adolescence Associate With Later Development of Diverticular Disease Requiring Hospitalization.

    PubMed

    Järbrink-Sehgal, M Ellionore; Schmidt, Peter T; Sköldberg, Filip; Hemmingsson, Tomas; Hagström, Hannes; Andreasson, Anna

    2018-04-12

    The burden of diverticular disease on society is high and is increasing with an aging population. It is therefore important to identify risk factors for disease development or progression. Many lifestyle behaviors during adolescence affect risk for later disease. We searched for adolescent lifestyle factors that affect risk of diverticular disease later in life. We performed a retrospective analysis of data from 43,772 men (age, 18-20 y) conscripted to military service in Sweden from 1969 through 1970, with a follow-up period of 39 years. All conscripts underwent an extensive mental and physical health examination and completed questionnaires covering alcohol consumption, smoking, and use of recreational drugs; cardiovascular fitness was assessed using an ergometer cycle at the time of conscription. Outcome data were collected from national registers to identify discharge diagnoses of diverticular disease until the end of 2009. We performed Cox regression analysis to determine whether body mass index, cardiovascular fitness, smoking, use of recreational drugs, alcohol consumption, and risky use of alcohol, at time of conscription are independent risk factors for development of diverticular disease. Overweight and obese men had a 2-fold increased risk of diverticular disease compared to normal-weight men (hazard ratio, 2.00; P < .001). A high level of cardiovascular fitness was associated with a reduced risk of diverticular disease requiring hospitalization (P = .009). Smoking (P = .003), but not use of recreational drugs (P = .11), was associated with an increased risk of diverticular disease requiring hospitalization. Risky use of alcohol, but not alcohol consumption per se, was associated with a 43% increase in risk of diverticular disease requiring hospitalization (P = .007). In a retrospective analysis of data from 43,772 men in Sweden, we associated being overweight or obese, a smoker, a high-risk user of alcohol, and/or having a low level of

  16. Epidermal growth factor receptor is required for estradiol-stimulated bovine satellite cell proliferation.

    PubMed

    Reiter, B C; Kamanga-Sollo, E; Pampusch, M S; White, M E; Dayton, W R

    2014-07-01

    The objective of this study was to assess the role of the epidermal growth factor receptor (EGFR) in estradiol-17β (E2)-stimulated proliferation of cultured bovine satellite cells (BSCs). Treatment of BSC cultures with AG1478 (a specific inhibitor of EGFR tyrosine kinase activity) suppresses E2-stimulated BSC proliferation (P < 0.05). In addition, E2-stimulated proliferation is completely suppressed (P < 0.05) in BSCs in which EGFR expression is silenced by treatment with EGFR small interfering RNA (siRNA). These results indicate that EGFR is required for E2 to stimulate proliferation in BSC cultures. Both AG1478 treatment and EGFR silencing also suppress proliferation stimulated by LR3-IGF-1 (an IGF1 analogue that binds normally to the insulin-like growth factor receptor (IGFR)-1 but has little or no affinity for IGF binding proteins) in cultured BSCs (P < 0.05). Even though EGFR siRNA treatment has no effect on IGFR-1β mRNA expression in cultured BSCs, IGFR-1β protein level is substantially reduced in BSCs treated with EGFR siRNA. These data suggest that EGFR silencing results in post-transcriptional modifications that result in decreased IGFR-1β protein levels. Although it is clear that functional EGFR is necessary for E2-stimulated proliferation of BSCs, the role of EGFR is not clear. Transactivation of EGFR may directly stimulate proliferation, or EGFR may function to maintain the level of IGFR-1β which is necessary for E2-stimulated proliferation. It also is possible that the role of EGFR in E2-stimulated BSC proliferation may involve both of these mechanisms. Copyright © 2014 Elsevier Inc. All rights reserved.

  17. Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.

    PubMed

    Stephen, Tom L; Rutkowski, Melanie R; Allegrezza, Michael J; Perales-Puchalt, Alfredo; Tesone, Amelia J; Svoronos, Nikolaos; Nguyen, Jenny M; Sarmin, Fahmida; Borowsky, Mark E; Tchou, Julia; Conejo-Garcia, Jose R

    2014-09-18

    Tumor-reactive T cells become unresponsive in advanced tumors. Here we have characterized a common mechanism of T cell unresponsiveness in cancer driven by the upregulation of the transcription factor Forkhead box protein P1 (Foxp1), which prevents CD8⁺ T cells from proliferating and upregulating Granzyme-B and interferon-γ in response to tumor antigens. Accordingly, Foxp1-deficient lymphocytes induced rejection of incurable tumors and promoted protection against tumor rechallenge. Mechanistically, Foxp1 interacted with the transcription factors Smad2 and Smad3 in preactivated CD8⁺ T cells in response to microenvironmental transforming growth factor-β (TGF-β), and was essential for its suppressive activity. Therefore, Smad2 and Smad3-mediated c-Myc repression requires Foxp1 expression in T cells. Furthermore, Foxp1 directly mediated TGF-β-induced c-Jun transcriptional repression, which abrogated T cell activity. Our results unveil a fundamental mechanism of T cell unresponsiveness different from anergy or exhaustion, driven by TGF-β signaling on tumor-associated lymphocytes undergoing Foxp1-dependent transcriptional regulation. Copyright © 2014 Elsevier Inc. All rights reserved.

  18. 7 CFR 1493.6 - Additional required determinations for GSM-103.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT... required determinations for GSM-103. Notwithstanding any other provision under this part, CCC shall not...

  19. 7 CFR 1493.6 - Additional required determinations for GSM-103.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT... required determinations for GSM-103. Notwithstanding any other provision under this part, CCC shall not...

  20. Vascular Endothelial Growth Factor and Angiopoietin are Required for Prostate Regeneration.

    PubMed Central

    Wang, Gui-min; Kovalenko, Bruce; Huang, Yili; Moscatelli, David

    2007-01-01

    BACKGROUND The regulation of the prostate size by androgens may be partly the result of androgen effects on the prostatic vasculature. We examined the effect of changes in androgen levels on the expression of a variety of angiogenic factors in the mouse prostate and determined if vascular endothelial growth factor (VEGF)-A and the angiopoietins are involved in the vascular response to androgens. METHODS Expression of angiogenic factors in prostate was quantitated using real-time PCR at different times after castration and after administration of testosterone to castrated mice. Angiopoietins were localized in prostate by immunohistochemistry and in situ hybridization. The roles of VEGF and the angiopoietins in regeneration of the prostate were examined in mice inoculated with cells expressing soluble VEGF receptor-2 or soluble Tie-2. RESULTS Castration resulted in a decrease in VEGF-A, VEGF-B, VEGF-C, placenta growth factor, FGF-2, and FGF-8 expression after one day. In contrast, VEGF-D mRNA levels increased. No changes in angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), hepatocyte growth factor, VEGF receptor-1, VEGF receptor-2 or tie-2 mRNA levels were observed. Administration of testosterone to castrated mice had the opposite effect on expression of these angiogenic factors. Ang-2 was expressed predominately in prostate epithelial cells whereas Ang-1 was expressed in epithelium and smooth muscle. Inoculation of mice with cells expressing soluble VEGF receptor-2 or Tie-2 blocked the increase in vascular density normally observed after administration of testosterone to castrated mice. The soluble receptors also blocked the increase in prostate weight and proliferation of prostatic epithelial cells. CONCLUSION VEGF-A and angiopoietins are required for the vascular response to androgens and for the ability of the prostate to regenerate in response to androgens. PMID:17221843

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