14 CFR 431.8 - Human space flight.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Human space flight. 431.8 Section 431.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) General § 431.8 Human space flight...

14 CFR 415.8 - Human space flight.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Human space flight. 415.8 Section 415.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE General § 415.8 Human space flight. To obtain a launch license, an...

14 CFR 415.8 - Human space flight.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Human space flight. 415.8 Section 415.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE General § 415.8 Human space flight. To obtain a launch license, an...

14 CFR 431.8 - Human space flight.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Human space flight. 431.8 Section 431.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) General § 431.8 Human space flight...

14 CFR § 1214.1705 - Selection of space flight participants.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Selection of space flight participants. § 1214.1705 Section § 1214.1705 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Space Flight Participants § 1214.1705 Selection of space flight participants. (a) The...

NASA Associate Administrator for Space Flight Rothenberg addresses guests at ribbon cutting for the

NASA Technical Reports Server (NTRS)

2000-01-01

NASA Associate Administrator for Space Flight Joseph Rothenberg addresses attendees at a ribbon cutting for the new Checkout and Launch Control System (CLCS) at the Hypergolic Maintenance Facility (HMF). The CLCS was declared operational in a ribbon cutting ceremony earlier. The new control room will be used to process the Orbital Maneuvering System pods and Forward Reaction Control System modules at the HMF. This hardware is removed from Space Shuttle orbiters and routinely taken to the HMF for checkout and servicing.

Human Space Flight Plans Committee Report

NASA Image and Video Library

2009-10-21

Copies of the U.S. Human Space Flight Plans Committee report are seen in the foreground of Chairman of the U.S. Human Space Flight Plans Committee Norman Augustine, left, and committee member Ed Crawley, right, during a press conference where the committee released it's report on Thursday, Oct., 22, 2009 at the National Press Club in Washington. The Obama Administration tasked the committee to do an independent review of planned U.S. human space flight activities with the goal of ensuring that the nation is on a vigorous and sustainable path to achieving its boldest aspirations in space. Photo Credit: (NASA/Bill Ingalls)

Results of the First US Manned Orbital Space Flight

NASA Technical Reports Server (NTRS)

1962-01-01

The results of the first United States manned orbital space flight conducted on February 20, 1962 are presented. The prelaunch activities, spacecraft description, flight operations, flight data, and postflight analyses presented form a continuation of the information previously published for the two United States manned suborbital space flights conducted on May 5, 1961, and July 21, 1961, respectively, by the National Aeronautics and Space Administration.

Space Flight-Associated Neuro-ocular Syndrome.

PubMed

Lee, Andrew G; Mader, Thomas H; Gibson, C Robert; Tarver, William

2017-09-01

New and unique physiologic and pathologic systemic and neuro-ocular responses have been documented in astronauts during and after long-duration space flight. Although the precise cause remains unknown, space flight-associated neuro-ocular syndrome (SANS) has been adopted as an appropriate descriptive term. The Space Medicine Operations Division of the US National Aeronautics and Space Administration (NASA) has documented the variable occurrence of SANS in astronauts returning from long-duration space flight on the International Space Station. These clinical findings have included unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and nerve fiber layer infarcts. The clinical findings of SANS have been correlated with structural changes on intraorbital and intracranial magnetic resonance imaging and in-flight and terrestrial ultrasonographic studies and ocular optical coherence tomography. Further study of SANS is ongoing for consideration of future manned missions to space, including a return trip to the moon or Mars.

Human Space Flight Plans Committee Report

NASA Image and Video Library

2009-10-21

U.S. Human Space Flight Plans Committee member Ed Crawley, right, answers a reporter's question during a press conference where the committee released it's report on Thursday, Oct., 22, 2009 at the National Press Club in Washington. The Obama Administration tasked the committee to do an independent review of planned U.S. human space flight activities with the goal of ensuring that the nation is on a vigorous and sustainable path to achieving its boldest aspirations in space. Photo Credit: (NASA/Bill Ingalls)

Human Space Flight Plans Committee Report

NASA Image and Video Library

2009-10-21

U.S. Human Space Flight Plans Committee member Ed Crawley answers a reporter's question during a press conference where the committee released it's report on Thursday, Oct., 22, 2009 at the National Press Club in Washington. The Obama Administration tasked the committee to do an independent review of planned U.S. human space flight activities with the goal of ensuring that the nation is on a vigorous and sustainable path to achieving its boldest aspirations in space. Photo Credit: (NASA/Bill Ingalls)

Human Space Flight Plans Committee Report

NASA Image and Video Library

2009-10-21

Copies of the U.S. Human Space Flight Plans Committee report are seen at a press conference where the committee released it's report findings on Thursday, Oct., 22, 2009 at the National Press Club in Washington. The Obama Administration tasked the committee to do an independent review of planned U.S. human space flight activities with the goal of ensuring that the nation is on a vigorous and sustainable path to achieving its boldest aspirations in space. Photo Credit: (NASA/Bill Ingalls)

Human Space Flight Plans Committee Report

NASA Image and Video Library

2009-10-21

Chairman of the U.S. Human Space Flight Plans Committee Norman Augustine, center, listens to reporters questions during a press conference where the committee released it's report on Thursday, Oct., 22, 2009 at the National Press Club in Washington. The Obama Administration tasked the committee to do an independent review of planned U.S. human space flight activities with the goal of ensuring that the nation is on a vigorous and sustainable path to achieving its boldest aspirations in space. Photo Credit: (NASA/Bill Ingalls)

Human Space Flight Plans Committee Report

NASA Image and Video Library

2009-10-21

Chairman of the U.S. Human Space Flight Plans Committee Norman Augustine answers a reporters question during a press conference where the committee released it's report on Thursday, Oct., 22, 2009 at the National Press Club in Washington. The Obama Administration tasked the committee to do an independent review of planned U.S. human space flight activities with the goal of ensuring that the nation is on a vigorous and sustainable path to achieving its boldest aspirations in space. Photo Credit: (NASA/Bill Ingalls)

Human Space Flight Plans Committee

NASA Image and Video Library

2009-06-16

Douglas R. Cooke, Associate Administrator for Exploration Systems Mission Directorate, at podium, addresses the Human Space Flight Review Committee, Wednesday, June 17, 2009, at the Carnegie Institution in Washington. The panel will examine ongoing and planned NASA development activities and potential alternatives in order to present options for advancing a safe, innovative, affordable and sustainable human space flight program following the space shuttle's retirement. The committee wil present its results by August 2009. Seated from left on the panel is Jeffrey Greason, Bohdan Bejmuk, Dr. Leroy Chiao, Norman Augustine (chair), Dr. Wanda Austin, Dr. Edward Crawley, Dr. Christopher Chyba and Philip McAlister. Photo Credit: (NASA/Paul E. Alers)

Human Space Flight Plans Committee Report

NASA Image and Video Library

2009-10-21

NASA Public Affairs Officer Doc Mirelson, left, and Chairman of the U.S. Human Space Flight Plans Committee Norman Augustine, right, listen to reporters questions during a press conference where the committee released it's report on Thursday, Oct., 22, 2009 at the National Press Club in Washington. The Obama Administration tasked the committee to do an independent review of planned U.S. human space flight activities with the goal of ensuring that the nation is on a vigorous and sustainable path to achieving its boldest aspirations in space. Photo Credit: (NASA/Bill Ingalls)

Proceedings of the Second Manned Space Flight Meeting

NASA Technical Reports Server (NTRS)

1964-01-01

The papers presented in this report represent the classified portion of the Second Manned Space Flight Meeting which was held in Dallas, TX, on April 22-24, 1963. The meeting was co-sponsored by the American Institute of Aeronautics and Astronautics and the National Aeronautics and Space Administration. The following subjects are discussed in the report: Manned Space Flight Programs, Launch Vehicles, Spacecraft Design, and Guidance and Control.

Manned Space Flight Experiments Symposium: Gemini Missions III and IV

NASA Technical Reports Server (NTRS)

1965-01-01

This is a compilation of papers on in-flight experiments presented at the first symposium of a series, Manned Space Flight Experiments Symposium, sponsored by the National Aeronautics and Space Administration. The results of experiments conducted during the Gemini Missions III and IV are covered. These symposiums are to be conducted for the scientific community at regular intervals on the results of experiments carried out in conjunction with manned space flights.

14 CFR 1214.1705 - Selection of space flight participants.

Code of Federal Regulations, 2012 CFR

2012-01-01

... persons or missions. (4) Adaptability to living and working in space. (5) Willingness to enter into an... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Selection of space flight participants. 1214.1705 Section 1214.1705 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE...

14 CFR 1214.1705 - Selection of space flight participants.

Code of Federal Regulations, 2010 CFR

2010-01-01

... persons or missions. (4) Adaptability to living and working in space. (5) Willingness to enter into an... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Selection of space flight participants. 1214.1705 Section 1214.1705 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE...

A prototype space flight intravenous injection system

NASA Technical Reports Server (NTRS)

Colombo, G. V.

1985-01-01

Medical emergencies, especially those resulting from accidents, frequently require the administration of intravenous fluids to replace lost body liquids. The development of a prototype space flight intravenous injection system is presented. The definition of requirements, injectable concentrates development, water polisher, reconstitution hardware development, administration hardware development, and prototype fabrication and testing are discussed.

National Aeronautics and Space Administration Biological Specimen Repository

NASA Technical Reports Server (NTRS)

McMonigal, Kathleen A.; Pietrzyk, Robert a.; Johnson, Mary Anne

2008-01-01

The National Aeronautics and Space Administration Biological Specimen Repository (Repository) is a storage bank that is used to maintain biological specimens over extended periods of time and under well-controlled conditions. Samples from the International Space Station (ISS), including blood and urine, will be collected, processed and archived during the preflight, inflight and postflight phases of ISS missions. This investigation has been developed to archive biosamples for use as a resource for future space flight related research. The International Space Station (ISS) provides a platform to investigate the effects of microgravity on human physiology prior to lunar and exploration class missions. The storage of crewmember samples from many different ISS flights in a single repository will be a valuable resource with which researchers can study space flight related changes and investigate physiological markers. The development of the National Aeronautics and Space Administration Biological Specimen Repository will allow for the collection, processing, storage, maintenance, and ethical distribution of biosamples to meet goals of scientific and programmatic relevance to the space program. Archiving of the biosamples will provide future research opportunities including investigating patterns of physiological changes, analysis of components unknown at this time or analyses performed by new methodologies.

Space Flight Immunodeficiency

NASA Technical Reports Server (NTRS)

Shearer, William T.

1999-01-01

The National Aeronautics and Space Administration (NASA) has had sufficient concern for the well-being of astronauts traveling in space to create the National Space Biomedical Research Institute (NSBRI), which is investigating several areas of biomedical research including those of immunology. As part of the Immunology, Infection, and Hematology Team, the co-investigators of the Space Flight Immunodeficiency Project began their research projects on April 1, 1998 and are now just into the second year of work. Two areas of research have been targeted: 1) specific immune (especially antibody) responses and 2) non-specific inflammation and adhesion. More precise knowledge of these two areas of research will help elucidate the potential harmful effects of space travel on the immune system, possibly sufficient to create a secondary state of immunodeficiency in astronauts. The results of these experiments are likely to lead to the delineation of functional alterations in antigen presentation, specific immune memory, cytokine regulation of immune responses, cell to cell interactions, and cell to endothelium interactions.

Human Space Flight

NASA Technical Reports Server (NTRS)

Woolford, Barbara; Mount, Frances

2004-01-01

The first human space flight, in the early 1960s, was aimed primarily at determining whether humans could indeed survive and function in micro-gravity. Would eating and sleeping be possible? What mental and physical tasks could be performed? Subsequent programs increased the complexity of the tasks the crew performed. Table 1 summarizes the history of U.S. space flight, showing the projects, their dates, crew sizes, and mission durations. With over forty years of experience with human space flight, the emphasis now is on how to design space vehicles, habitats, and missions to produce the greatest returns to human knowledge. What are the roles of the humans in space flight in low earth orbit, on the moon, and in exploring Mars?

Effects of Space Flight on Ovarian-Hypophyseal Function in Postpartum Rats

NASA Technical Reports Server (NTRS)

Burden, H. W.; Zary, J.; Lawrence, I. E.; Jonnalagadda, P.; Davis, M.; Hodson, C. A.

1997-01-01

The effect of space flight in a National Aeronautics and Space Administration (NASA) shuttle was studied in pregnant rats. Rats were launched on day 9 of gestation and recovered on day 20 of gestation. On day 20 of gestation, rats were unilaterally hysterectomized and subsequently allowed to go to term and deliver vaginally. There was no effect of space flight on pituitary and ovary mass postpartum. In addition, space flight did not alter healthy and atretic ovarian antral follicle populations, fetal wastage in utero, plasma concentrations of progesterone and luteinizing hormone (LH) or pituitary content of follicle stimulating hormone (FSH). Space flight significantly increased plasma concentrations of FSH and decreased pituitary content of LH at the postpartum sampling time. Collectively, these data show that space flight, initiated during the postimplantation period of pregnancy, and concluded before parturition, is compatible with maintenance of pregnancy and has minimal effects on postpartum hypophyseal parameters; however, none of the ovarian parameters examined was altered by space flight.

Workshop on Exercise Prescription for Long-Duration Space Flight

NASA Technical Reports Server (NTRS)

Harris, Bernard A., Jr. (Editor); Stewart, Donald F. (Editor)

1989-01-01

The National Aeronautics and Space Administration has a dedicated history of ensuring human safety and productivity in flight. Working and living in space long term represents the challenge of the future. Our concern is in determining the effects on the human body of living in space. Space flight provides a powerful stimulus for adaptation, such as cardiovascular and musculoskeletal deconditioning. Extended-duration space flight will influence a great many systems in the human body. We must understand the process by which this adaptation occurs. The NASA is agressively involved in developing programs which will act as a foundation for this new field of space medicine. The hallmark of these programs deals with prevention of deconditioning, currently referred to as countermeasures to zero g. Exercise appears to be most effective in preventing the cardiovascular and musculoskeletal degradation of microgravity.

Space flight-associated neuro-ocular syndrome (SANS).

PubMed

Lee, Andrew G; Mader, Thomas H; Gibson, C Robert; Brunstetter, Tyson J; Tarver, William J

2018-03-12

Interesting novel and somewhat perplexing physiologic and pathologic neuro-ocular findings have been documented in astronauts during and after long duration space flight (LDSF). These findings collectively have been termed the "space flight-associated neuro-ocular syndrome" (SANS). The National Aeronautics and Space Administration (NASA) in the United States has meticulously and prospectively documented the clinical, ultrasound, optical coherence tomography imaging, and radiographic findings of SANS including unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and nerve fiber layer infarcts (i.e., cotton wool spots). NASA and collaborating researchers continue to study SANS in preparation for future manned missions to space, including continued trips to the ISS, a return to the moon, or perhaps new voyages to the asteroid belt, or the planet, Mars.

Modeling Calcium Loss from Bones During Space Flight

NASA Technical Reports Server (NTRS)

Wastney, Meryl E.; Morukov, Boris V.; Larina, Irina M.; Abrams, Steven A.; Nillen, Jeannie L.; Davis-Street, Janis E.; Lane, Helen W.; Smith, Scott M.; Paloski, W. H. (Technical Monitor)

1999-01-01

Calcium loss from bones during space flight creates a risk for astronauts who travel into space, and may prohibit space flights to other planets. The problem of calcium loss during space flight has been studied using animal models, bed rest (as a ground-based model), and humans in-flight. In-flight studies have typically documented bone loss by comparing bone mass before and after flight. To identify changes in metabolism leading to bone loss, we have performed kinetic studies using stable isotopes of calcium. Oral (Ca-43) and intravenous (Ca-46) tracers were administered to subjects (n=3), three-times before flight, once in-flight (after 110 days), and three times post-flight (on landing day, and 9 days and 3 months after flight). Samples of blood, saliva, urine, and feces were collected for up to 5 days after isotope administration, and were analyzed for tracer enrichment. Tracer data in tissues were analyzed using a compartmental model for calcium metabolism and the WinSAAM software. The model was used to: account for carryover of tracer between studies, fit data for all studies using the minimal number of changes between studies, and calculate calcium absorption, excretion, bone calcium deposition and bone calcium resorption. Results showed that fractional absorption decreased by 50% during flight and that bone resorption and urinary excretion increased by 50%. Results were supported by changes in biochemical markers of bone metabolism. Inflight bone loss of approximately 250 mg Ca/d resulted from decreased calcium absorption combined with increased bone resorption and excretion. Further studies will assess the time course of these changes during flight, and the effectiveness of countermeasures to mitigate flight-induced bone loss. The overall goal is to enable human travel beyond low-Earth orbit, and to allow for better understanding and treatment of bone diseases on Earth.

An assessment of space shuttle flight software development processes

NASA Technical Reports Server (NTRS)

1993-01-01

In early 1991, the National Aeronautics and Space Administration's (NASA's) Office of Space Flight commissioned the Aeronautics and Space Engineering Board (ASEB) of the National Research Council (NRC) to investigate the adequacy of the current process by which NASA develops and verifies changes and updates to the Space Shuttle flight software. The Committee for Review of Oversight Mechanisms for Space Shuttle Flight Software Processes was convened in Jan. 1992 to accomplish the following tasks: (1) review the entire flight software development process from the initial requirements definition phase to final implementation, including object code build and final machine loading; (2) review and critique NASA's independent verification and validation process and mechanisms, including NASA's established software development and testing standards; (3) determine the acceptability and adequacy of the complete flight software development process, including the embedded validation and verification processes through comparison with (1) generally accepted industry practices, and (2) generally accepted Department of Defense and/or other government practices (comparing NASA's program with organizations and projects having similar volumes of software development, software maturity, complexity, criticality, lines of code, and national standards); (4) consider whether independent verification and validation should continue. An overview of the study, independent verification and validation of critical software, and the Space Shuttle flight software development process are addressed. Findings and recommendations are presented.

Space Flight. Teacher Resources.

ERIC Educational Resources Information Center

2001

This teacher's guide contains information, lesson plans, and diverse student learning activities focusing on space flight. The guide is divided into seven sections: (1) "Drawing Activities" (Future Flight; Space Fun; Mission: Draw); (2) "Geography" (Space Places); (3) "History" (Space and Time); (4)…

The National Aeronautics and Space Administration (NASA)/Goddard Space Flight Center (GSFC) sounding-rocket program

NASA Technical Reports Server (NTRS)

Guidotti, J. G.

1976-01-01

An overall introduction to the NASA sounding rocket program as managed by the Goddard Space Flight Center is presented. The various sounding rockets, auxiliary systems (telemetry, guidance, etc.), launch sites, and services which NASA can provide are briefly described.

Energy requirements for space flight

NASA Technical Reports Server (NTRS)

Lane, Helen W.

1992-01-01

Both the United States and the Soviet Union perform human space research. This paper reviews data available on energy metabolism in the microgravity of space flight. The level of energy utilization in space seems to be similar to that on earth, as does energy availability. However, despite adequate intake of energy and protein and in-flight exercise, lean body mass was catabolized, as indicated by negative nitrogen balance. Metabolic studies during simulated microgravity (bed rest) and true microgravity in flight have shown changes in blood glucose, fatty acids and insulin concentrations, suggesting that energy metabolism may be altered during space flight. Future research should focus on the interactions of lean body mass, diet and exercise in space, and their roles in energy metabolism during space flight.

Immune responses in space flight

NASA Technical Reports Server (NTRS)

Sonnenfeld, G.

1998-01-01

Space flight has been shown to have profound effects on immunological parameters of humans, monkeys and rodents. These studies have been carried out by a number of different laboratories. Among the parameters affected are leukocyte blastogenesis, natural killer cell activity, leukocyte subset distribution, cytokine production - including interferons and interleukins, and macrophage maturation and activity. These changes start to occur only after a few days space flight, and some changes continue throughout long-term space flight. Antibody responses have received only very limited study, and total antibody levels have been shown to be increased after long-term space flight. Several factors could be involved in inducing these changes. These factors could include microgravity, lack of load-bearing, stress, acceleration forces, and radiation. The mechanism(s) for space flight-induced changes in immune responses remain(s) to be established. Certainly, there can be direct effects of microgravity, or other factors, on cells that play a fundamental role in immune responses. However, it is now clear that there are interactions between the immune system and other physiological systems that could play a major role. For example, changes occurring in calcium use in the musculoskeletal system induced by microgravity or lack of use could have great impact on the immune system. Most of the changes in immune responses have been observed using samples taken immediately after return from space flight. However, there have been two recent studies that have used in-flight testing. Delayed-type hypersensitivity responses to common recall antigens of astronauts and cosmonauts have been shown to be decreased when tested during space flights. Additionally, natural killer cell and blastogenic activities are inhibited in samples taken from rats during space flight. Therefore, it is now clear that events occurring during space flight itself can affect immune responses. The biological

ASTAR Flight Test: Overview and Spacing Results

NASA Technical Reports Server (NTRS)

Roper, Roy D.; Koch, Michael R.

2016-01-01

The purpose of the NASA Langley Airborne Spacing for Terminal Arrival Routes (ASTAR) research aboard the Boeing ecoDemonstrator aircraft was to demonstrate the use of NASA's ASTAR algorithm using contemporary tools of the Federal Aviation Administration's Next Generation Air Transportation System (NEXTGEN). EcoDemonstrator is a Boeing test program which utilizes advanced experimental equipment to accelerate the science of aerospace and environmentally friendly technologies. The ASTAR Flight Test provided a proof-of-concept flight demonstration that exercised an algorithmic-based application in an actual aircraft. The test aircraft conducted Interval Management operations to provide time-based spacing off a target aircraft in non-simulator wind conditions. Work was conducted as a joint effort between NASA and Boeing to integrate ASTAR in a Boeing supplied B787 test aircraft while using a T-38 aircraft as the target. This demonstration was also used to identify operational risks to future flight trials for the NASA Air Traffic Management Technology Demonstration expected in 2017.

Magnesium and Space Flight.

PubMed

Smith, Scott M; Zwart, Sara R

2015-12-08

Magnesium is an essential nutrient for muscle, cardiovascular, and bone health on Earth, and during space flight. We sought to evaluate magnesium status in 43 astronauts (34 male, 9 female; 47 ± 5 years old, mean ± SD) before, during, and after 4-6-month space missions. We also studied individuals participating in a ground analog of space flight (head-down-tilt bed rest; n = 27 (17 male, 10 female), 35 ± 7 years old). We evaluated serum concentration and 24-h urinary excretion of magnesium, along with estimates of tissue magnesium status from sublingual cells. Serum magnesium increased late in flight, while urinary magnesium excretion was higher over the course of 180-day space missions. Urinary magnesium increased during flight but decreased significantly at landing. Neither serum nor urinary magnesium changed during bed rest. For flight and bed rest, significant correlations existed between the area under the curve of serum and urinary magnesium and the change in total body bone mineral content. Tissue magnesium concentration was unchanged after flight and bed rest. Increased excretion of magnesium is likely partially from bone and partially from diet, but importantly, it does not come at the expense of muscle tissue stores. While further study is needed to better understand the implications of these findings for longer space exploration missions, magnesium homeostasis and tissue status seem well maintained during 4-6-month space missions.

14 CFR 121.493 - Flight time limitations: Flight engineers and flight navigators.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight time limitations: Flight engineers and flight navigators. 121.493 Section 121.493 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Time...

14 CFR 121.493 - Flight time limitations: Flight engineers and flight navigators.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight time limitations: Flight engineers and flight navigators. 121.493 Section 121.493 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Time...

14 CFR 121.493 - Flight time limitations: Flight engineers and flight navigators.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight time limitations: Flight engineers and flight navigators. 121.493 Section 121.493 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Time...

14 CFR 121.493 - Flight time limitations: Flight engineers and flight navigators.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight time limitations: Flight engineers and flight navigators. 121.493 Section 121.493 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Time...

14 CFR 121.493 - Flight time limitations: Flight engineers and flight navigators.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight time limitations: Flight engineers and flight navigators. 121.493 Section 121.493 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Time...

Long-Duration Space Flight

NASA Technical Reports Server (NTRS)

1997-01-01

Session WA1 includes short reports concerning: (1) Medical and Physiological Studies During 438-Day Space Flights: (2) Human Performance During a 14 Month Space Mission: (3) Homeostasis in Long-Term Microgravity Conditions; (4) Strategy of Preservation of Health of Cosmonauts in Prolonged and Superprolonged Space Flights; (5) Rehabilitation of Cosmonauts Health Following Long-Term Space Missions; and (6) Perfect Cosmonauts: Some Features of Bio-Portrait.

Magnesium and Space Flight

PubMed Central

Smith, Scott M.; Zwart, Sara R.

2015-01-01

Magnesium is an essential nutrient for muscle, cardiovascular, and bone health on Earth, and during space flight. We sought to evaluate magnesium status in 43 astronauts (34 male, 9 female; 47 ± 5 years old, mean ± SD) before, during, and after 4–6-month space missions. We also studied individuals participating in a ground analog of space flight (head-down-tilt bed rest; n = 27 (17 male, 10 female), 35 ± 7 years old). We evaluated serum concentration and 24-h urinary excretion of magnesium, along with estimates of tissue magnesium status from sublingual cells. Serum magnesium increased late in flight, while urinary magnesium excretion was higher over the course of 180-day space missions. Urinary magnesium increased during flight but decreased significantly at landing. Neither serum nor urinary magnesium changed during bed rest. For flight and bed rest, significant correlations existed between the area under the curve of serum and urinary magnesium and the change in total body bone mineral content. Tissue magnesium concentration was unchanged after flight and bed rest. Increased excretion of magnesium is likely partially from bone and partially from diet, but importantly, it does not come at the expense of muscle tissue stores. While further study is needed to better understand the implications of these findings for longer space exploration missions, magnesium homeostasis and tissue status seem well maintained during 4–6-month space missions. PMID:26670248

Nutritional Biochemistry of Space Flight

NASA Technical Reports Server (NTRS)

Smith, Scott M.

2000-01-01

Adequate nutrition is critical for maintenance of crew health during and after extended-duration space flight. The impact of weightlessness on human physiology is profound, with effects on many systems related to nutrition, including bone, muscle, hematology, fluid and electrolyte regulation. Additionally, we have much to learn regarding the impact of weightlessness on absorption, mtabolism , and excretion of nutrients, and this will ultimately determine the nutrient requirements for extended-duration space flight. Existing nutritional requirements for extended-duration space flight have been formulated based on limited flight research, and extrapolation from ground-based research. NASA's Nutritional Biochemistry Laboratory is charged with defining the nutritional requirements for space flight. This is accomplished through both operational and research projects. A nutritional status assessment program is included operationally for all International Space Station astronauts. This medical requirement includes biochemical and dietary assessments, and is completed before, during, and after the missions. This program will provide information about crew health and nutritional status, and will also provide assessments of countermeasure efficacy. Ongoing research projects include studies of calcium and bone metabolism, and iron absorption and metabolism. The calcium studies include measurements of endocrine regulation of calcium homeostasis, biochemical marker of bone metabolism, and tracer kinetic studies of calcium movement in the body. These calcium kinetic studies allow for estimation of intestinal absorption, urinary excretion, and perhaps most importantly - deposition and resorption of calcium from bone. The Calcium Kinetics experiment is currently being prepared for flight on the Space Shuttle in 2001, and potentially for subsequent Shuttle and International Space Station missions. The iron study is intended to assess whether iron absorption is down-regulated dUl1ng

14 CFR 1214.101 - Eligibility for flight of a non-U.S. government reimbursable payload on the Space Shuttle.

Code of Federal Regulations, 2012 CFR

2012-01-01

.... government reimbursable payload on the Space Shuttle. 1214.101 Section 1214.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT General Provisions Regarding Space Shuttle... non-U.S. government reimbursable payload on the Space Shuttle. To be eligible for flight on the Space...

14 CFR 1214.101 - Eligibility for flight of a non-U.S. government reimbursable payload on the Space Shuttle.

Code of Federal Regulations, 2013 CFR

2013-01-01

.... government reimbursable payload on the Space Shuttle. 1214.101 Section 1214.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT General Provisions Regarding Space Shuttle... non-U.S. government reimbursable payload on the Space Shuttle. To be eligible for flight on the Space...

14 CFR 1214.101 - Eligibility for flight of a non-U.S. government reimbursable payload on the Space Shuttle.

Code of Federal Regulations, 2011 CFR

2011-01-01

.... government reimbursable payload on the Space Shuttle. 1214.101 Section 1214.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT General Provisions Regarding Space Shuttle... non-U.S. government reimbursable payload on the Space Shuttle. To be eligible for flight on the Space...

Calcium Kinetics During Space Flight

NASA Technical Reports Server (NTRS)

Smith, Scott M.; OBrien, K. O.; Abrams, S. A.; Wastney, M. E.

2005-01-01

Bone loss during space flight is one of the most critical challenges to astronaut health on space exploration missions. Defining the time course and mechanism of these changes will aid in developing means to counteract bone loss during space flight, and will have relevance for other clinical situations that impair weight-bearing activity. Bone health is a product of the balance between bone formation and bone resorption. Early space research could not clearly identify which of these was the main process altered in bone loss, but identification of the collagen crosslinks in the 1990s made possible a clear understanding that the impact of space flight was greater on bone resorption, with bone formation being unchanged or only slightly decreased. Calcium kinetics data showed that bone resorption was greater during flight than before flight (668 plus or minus 130 vs. 427 plus or minus 153 mg/d, p less than 0.001), and clearly documented that true intestinal calcium absorption was lower during flight than before flight (233 plus or minus 87 vs. 460 plus or minus 47 mg/d, p less than 0.01). Weightlessness had a detrimental effect on the balance in bone turnover: the difference between daily calcium balance during flight (-234 plus or minus 102 mg/d) and calcium balance before flight (63 plus or minus 75 mg/d) approached 300 mg/d (p less than 0.01). These data demonstrate that the bone loss that occurs during space flight is a consequence of increased bone resorption and decreased intestinal calcium absorption. Examining the changes in bone and calcium homeostasis in the initial days and weeks of space flight, as well as at later times on missions longer than 6 months, is critical to understanding the nature of bone adaptation to weightlessness. To increase knowledge of these changes, we studied bone adaptation to space flight on the 16-day Space Shuttle Columbia (STS-107) mission. When the brave and talented crew of Columbia were lost during reentry on the tragic morning

Immune function during space flight

NASA Technical Reports Server (NTRS)

Sonnenfeld, Gerald; Shearer, William T.

2002-01-01

It is very likely that the human immune system will be altered in astronauts exposed to the conditions of long-term space flight: isolation, containment, microgravity, radiation, microbial contamination, sleep disruption, and insufficient nutrition. In human and animal subjects flown in space, there is evidence of immune compromise, reactivation of latent virus infection, and possible development of a premalignant or malignant condition. Moreover, in ground-based space flight model investigations, there is evidence of immune compromise and reactivation of latent virus infection. All of these observations in space flight itself or in ground-based models of space flight have a strong resonance in a wealth of human pathologic conditions involving the immune system where reactivated virus infections and cancer appear as natural consequences. The clinical conditions of Epstein-Barr-driven lymphomas in transplant patients and Kaposi's sarcoma in patients with autoimmune deficiency virus come easily to mind in trying to identify these conditions. With these thoughts in mind, it is highly appropriate, indeed imperative, that careful investigations of human immunity, infection, and cancer be made by space flight researchers.

Young PHD's in Human Space Flight

NASA Technical Reports Server (NTRS)

Wilson, Eleanor

2002-01-01

The Cooperating Hampton Roads Organizations for Minorities in Engineering (CHROME) in cooperation with the NASA Office of Space Flight, Human Exploration and Development of Space Enterprise sponsored a summer institute, Young PHD#s (Persons Having Dreams) in Human Space Flight. This 3-day institute used the curriculum of a workshop designed for space professionals, 'Human Space Flight-Analysis and Design: An Integrated, Systematic Approach.' The content was tailored to a high school audience. This institute seeks to stimulate the interest of pre-college students in space flight and motivate them to pursue further experiences in this field. Additionally, this institute will serve as a pilot model for a pre- collegiate training program that can be replicated throughout the country. The institute was complemented with a trip to the Goddard Space Flight Center.

First Semiannual Report of the National Aeronautics and Space Administration

NASA Technical Reports Server (NTRS)

Glennan, T. Keith

1959-01-01

The First Semiannual Report of the National Aeronautics and Space Administration (NASA) is submitted to Congress pursuant to section 206 (a) of the National Aeronautics and Space Act of 1958 (Public Law 85-568) to provide for research into problems of flight within and outside the Earth's atmosphere, which states: The Administration shall submit to the President for transmittal to Congress, semiannually and at such other times as it deems desirable, a report on its activities and accomplishments.

Optical Fiber Assemblies for Space Flight from the NASA Goddard Space Flight Center, Photonics Group

NASA Technical Reports Server (NTRS)

Ott, Melanie N.; Thoma, William Joe; LaRocca, Frank; Chuska, Richard; Switzer, Robert; Day, Lance

2009-01-01

The Photonics Group at NASA Goddard Space Flight Center in the Electrical Engineering Division of the Advanced Engineering and Technologies Directorate has been involved in the design, development, characterization, qualification, manufacturing, integration and anomaly analysis of optical fiber subsystems for over a decade. The group supports a variety of instrumentation across NASA and outside entities that build flight systems. Among the projects currently supported are: The Lunar Reconnaissance Orbiter, the Mars Science Laboratory, the James Webb Space Telescope, the Express Logistics Carrier for the International Space Station and the NASA Electronic Parts. and Packaging Program. A collection of the most pertinent information gathered during project support over the past year in regards to space flight performance of optical fiber components is presented here. The objective is to provide guidance for future space flight designs of instrumentation and communication systems.

Development of countermeasures for use in space missions. [to adaptive response to space flight

NASA Technical Reports Server (NTRS)

Nicogossian, A. E. T.; Pool, S.; Huntoon, C. S. L.; Leonard, J. I.

1985-01-01

Several measures used to mitigate the inappropriate adaptive responses of space flight are investigated. Weighlessness results in a cephalic fluid shift, which causes a reduction in the circulating blood volume, and removal of weight bearing forces from musculoskeletal systems. The physiological changes that occur from one-g initiated hypovolemia and zero-g initiated fluild shifts are analyzed and compared. The role of barorecptors on the activation of the adrenergic responses that occurs as a result of hypovolemia is studied. The proper selection and administration of in-flight and post flight countermeasures, which include passive and active physical conditioning techniques, drugs, and vitamins are examined.

Biotechnological experiments in space flights on board of space stations

NASA Astrophysics Data System (ADS)

Nechitailo, Galina S.

2012-07-01

Space flight conditions are stressful for any plant and cause structural-functional transition due to mobiliation of adaptivity. In space flight experiments with pea tissue, wheat and arabidopsis we found anatomical-morphological transformations and biochemistry of plants. In following experiments, tissue of stevia (Stevia rebaudiana), potato (Solanum tuberosum), callus culture and culture and bulbs of suffron (Crocus sativus), callus culture of ginseng (Panax ginseng) were investigated. Experiments with stevia carried out in special chambers. The duration of experiment was 8-14 days. Board lamp was used for illumination of the plants. After experiment the plants grew in the same chamber and after 50 days the plants were moved into artificial ionexchange soil. The biochemical analysis of plants was done. The total concentration of glycozides and ratio of stevioside and rebauside were found different in space and ground plants. In following generations of stevia after flight the total concentration of stevioside and rebauside remains higher than in ground plants. Experiments with callus culture of suffron carried out in tubes. Duration of space flight experiment was 8-167 days. Board lamp was used for illumination of the plants. We found picrocitina pigment in the space plants but not in ground plants. Tissue culture of ginseng was grown in special container in thermostate under stable temperature of 22 ± 0,5 C. Duration of space experiment was from 8 to 167 days. Biological activity of space flight culutre was in 5 times higher than the ground culture. This difference was observed after recultivation of space flight samples on Earth during year after flight. Callus tissue of potato was grown in tubes in thermostate under stable temperature of 22 ± 0,5 C. Duration of space experiment was from 8 to 14 days. Concentration of regenerates in flight samples was in 5 times higher than in ground samples. The space flight experiments show, that microgravity and other

14 CFR § 1214.101 - Eligibility for flight of a non-U.S. government reimbursable payload on the Space Shuttle.

Code of Federal Regulations, 2014 CFR

2014-01-01

.... government reimbursable payload on the Space Shuttle. § 1214.101 Section § 1214.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT General Provisions Regarding Space Shuttle... non-U.S. government reimbursable payload on the Space Shuttle. To be eligible for flight on the Space...

Kodak Mirror Assembly Tested at Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

2003-01-01

This photo (rear view) is of one of many segments of the Eastman-Kodak mirror assembly being tested for the James Webb Space Telescope (JWST) project at the X-Ray Calibration Facility at Marshall Space Flight Center (MSFC). MSFC is supporting Goddard Space Flight Center (GSFC) in developing the JWST by taking numerous measurements to predict its future performance. The tests are conducted in a vacuum chamber cooled to approximate the super cold temperatures found in space. During its 27 years of operation, the facility has performed testing in support of a wide array of projects, including the Hubble Space Telescope (HST), Solar A, Chandra technology development, Chandra High Resolution Mirror Assembly and science instruments, Constellation X-Ray Mission, and Solar X-Ray Imager, currently operating on a Geostationary Operational Environment Satellite. The JWST is NASA's next generation space telescope, a successor to the Hubble Space Telescope, named in honor of NASA's second administrator, James E. Webb. It is scheduled for launch in 2010 aboard an expendable launch vehicle. It will take about 3 months for the spacecraft to reach its destination, an orbit of 940,000 miles in space.

Kodak Mirror Assembly Tested at Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

2003-01-01

The Eastman-Kodak mirror assembly is being tested for the James Webb Space Telescope (JWST) project at the X-Ray Calibration Facility at Marshall Space Flight Center (MSFC). In this photo, an MSFC employee is inspecting one of many segments of the mirror assembly for flaws. MSFC is supporting Goddard Space Flight Center (GSFC) in developing the JWST by taking numerous measurements to predict its future performance. The tests are conducted in a vacuum chamber cooled to approximate the super cold temperatures found in space. During its 27 years of operation, the facility has performed testing in support of a wide array of projects, including the Hubble Space Telescope (HST), Solar A, Chandra technology development, Chandra High Resolution Mirror Assembly and science instruments, Constellation X-Ray Mission, and Solar X-Ray Imager, currently operating on a Geostationary Operational Environment Satellite. The JWST is NASA's next generation space telescope, a successor to the Hubble Space Telescope, named in honor of NASA's second administrator, James E. Webb. It is scheduled for launch in 2010 aboard an expendable launch vehicle. It will take about 3 months for the spacecraft to reach its destination, an orbit of 940,000 miles in space.

Kodak Mirror Assembly Tested at Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

2003-01-01

This photo (a frontal view) is of one of many segments of the Eastman-Kodak mirror assembly being tested for the James Webb Space Telescope (JWST) project at the X-Ray Calibration Facility at Marshall Space Flight Center (MSFC). MSFC is supporting Goddard Space Flight Center (GSFC) in developing the JWST by taking numerous measurements to predict its future performance. The tests are conducted in a vacuum chamber cooled to approximate the super cold temperatures found in space. During its 27 years of operation, the facility has performed testing in support of a wide array of projects, including the Hubble Space Telescope (HST), Solar A, Chandra technology development, Chandra High Resolution Mirror Assembly and science instruments, Constellation X-Ray Mission, and Solar X-Ray Imager, currently operating on a Geostationary Operational Environment Satellite. The JWST is NASA's next generation space telescope, a successor to the Hubble Space Telescope, named in honor of NASA's second administrator, James E. Webb. It is scheduled for launch in 2010 aboard an expendable launch vehicle. It will take about 3 months for the spacecraft to reach its destination, an orbit of 940,000 miles in space.

Kodak Mirror Assembly Tested at Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

2003-01-01

This photo (a side view) is of one of many segments of the Eastman-Kodak mirror assembly being tested for the James Webb Space Telescope (JWST) project at the X-Ray Calibration Facility at Marshall Space Flight Center (MSFC). MSFC is supporting Goddard Space Flight Center (GSFC) in developing the JWST by taking numerous measurements to predict its future performance. The tests are conducted in a vacuum chamber cooled to approximate the super cold temperatures found in space. During its 27 years of operation, the facility has performed testing in support of a wide array of projects, including the Hubble Space Telescope (HST), Solar A, Chandra technology development, Chandra High Resolution Mirror Assembly and science instruments, Constellation X-Ray Mission, and Solar X-Ray Imager, currently operating on a Geostationary Operational Environment Satellite. The JWST is NASA's next generation space telescope, a successor to the Hubble Space Telescope, named in honor of NASA's second administrator, James E. Webb. It is scheduled for launch in 2010 aboard an expendable launch vehicle. It will take about 3 months for the spacecraft to reach its destination, an orbit of 940,000 miles in space.

Space Flight Applications of Optical Fiber; 30 Years of Space Flight Success

NASA Technical Reports Server (NTRS)

Ott, Melanie N.

2010-01-01

For over thirty years NASA has had success with space flight missions that utilize optical fiber component technology. One of the early environmental characterization experiments that included optical fiber was launched as the Long Duration Exposure Facility in 1978. Since then, multiple missions have launched with optical fiber components that functioned as expected, without failure throughout the mission life. The use of optical fiber in NASA space flight communications links and exploration and science instrumentation is reviewed.

14 CFR 121.425 - Flight engineers: Initial and transition flight training.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight engineers: Initial and transition flight training. 121.425 Section 121.425 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 121.425 Flight engineers: Initial and transition flight training. (a) Initial and transition flight...

14 CFR 121.425 - Flight engineers: Initial and transition flight training.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight engineers: Initial and transition flight training. 121.425 Section 121.425 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 121.425 Flight engineers: Initial and transition flight training. (a) Initial and transition flight...

14 CFR 121.426 - Flight navigators: Initial and transition flight training.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight navigators: Initial and transition flight training. 121.426 Section 121.426 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 121.426 Flight navigators: Initial and transition flight training. (a) Initial and transition flight...

14 CFR 121.426 - Flight navigators: Initial and transition flight training.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight navigators: Initial and transition flight training. 121.426 Section 121.426 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 121.426 Flight navigators: Initial and transition flight training. (a) Initial and transition flight...

14 CFR 121.425 - Flight engineers: Initial and transition flight training.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight engineers: Initial and transition flight training. 121.425 Section 121.425 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 121.425 Flight engineers: Initial and transition flight training. (a) Initial and transition flight...

14 CFR 121.426 - Flight navigators: Initial and transition flight training.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight navigators: Initial and transition flight training. 121.426 Section 121.426 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 121.426 Flight navigators: Initial and transition flight training. (a) Initial and transition flight...

14 CFR 121.426 - Flight navigators: Initial and transition flight training.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight navigators: Initial and transition flight training. 121.426 Section 121.426 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 121.426 Flight navigators: Initial and transition flight training. (a) Initial and transition flight...

14 CFR 121.425 - Flight engineers: Initial and transition flight training.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight engineers: Initial and transition flight training. 121.425 Section 121.425 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 121.425 Flight engineers: Initial and transition flight training. (a) Initial and transition flight...

14 CFR 121.425 - Flight engineers: Initial and transition flight training.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight engineers: Initial and transition flight training. 121.425 Section 121.425 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 121.425 Flight engineers: Initial and transition flight training. (a) Initial and transition flight...

Friction Stir Welding Development at National Aeronautics and Space Administration-Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Bhat, Biliyar N.; Carter, Robert W.; Ding, Robert J.; Lawless, Kirby G.; Nunes, Arthur C., Jr.; Russell, Carolyn K.; Shah, Sandeep R.; Munafo, Paul M. (Technical Monitor)

2001-01-01

This paper presents an over-view of friction stir welding (FSW) process development and applications at Marshall Space Flight Center (MSFC). FSW process development started as a laboratory curiosity but soon found support from many users. The FSW process advanced very quickly and has found many applications both within and outside the aerospace industry. It is currently being adapted for joining key elements of the Space Shuttle External Tank for improved producibility and reliability. FSW process modeling is done to better understand and improve the process. Special tools have been developed to weld variable thickness materials including very thin and very thick materials. FSW is now being applied to higher temperature materials such as copper and to advanced materials such as metal matrix composites. FSW technology is being successfully transferred from MSFC laboratory to shop floors of many commercial companies.

Calbindins decreased after space flight

NASA Technical Reports Server (NTRS)

Sergeev, I. N.; Rhoten, W. B.; Carney, M. D.

1996-01-01

Exposure of the body to microgravity during space flight causes a series of well-documented changes in Ca2+ metabolism, yet the cellular and molecular mechanisms leading to these changes are poorly understood. Calbindins, vitamin D-dependent Ca2+ binding proteins, are believed to have a significant role in maintaining cellular Ca2+ homeostasis. In this study, we used biochemical and immunocytochemical approaches to analyze the expression of calbindin-D28k and calbindin-D9k in kidneys, small intestine, and pancreas of rats flown for 9 d aboard the space shuttle. The effects of microgravity on calbindins in rats from space were compared with synchronous Animal Enclosure Module controls, modeled weightlessness animals (tail suspension), and their controls. Exposure to microgravity resulted in a significant and sustained decrease in calbindin-D28k content in the kidney and calbindin-D9k in the small intestine of flight animals, as measured by enzyme-linked immunosorbent assay (ELISA). Modeled weightlessness animals exhibited a similar decrease in calbindins by ELISA. Immunocytochemistry (ICC) in combination with quantitative computer image analysis was used to measure in situ the expression of calbindins in the kidney and the small intestine, and the expression of insulin in pancreas. There was a large decrease of immunoreactivity in renal distal tubular cell-associated calbindin-D28k and in intestinal absorptive cell-associated calbindin-D9k of space flight and modeled weightlessness animals compared with matched controls. No consistent difference in pancreatic insulin immunoreactivity between space flight, modeled weightlessness, and controls was observed. Regression analysis of results obtained by quantitative ICC and ELISA for space flight, modeled weightlessness animals, and their controls demonstrated a significant correlation. These findings after a short-term exposure to microgravity or modeled weightlessness suggest that a decreased expression of calbindins

Space Flight: The First 30 Years

NASA Technical Reports Server (NTRS)

1991-01-01

A history of space flight from Project Mercury to the Space Shuttle is told from the perspective of NASA flight programs. Details are given on Mercury missions, Gemini missions, Apollo missions, Skylab missions, the Apollo-Soyuz Test Project, and the Space Shuttle missions.

Soviet space flight: the human element.

PubMed

Garshnek, V

1988-05-01

Building on past experience and knowledge, the Soviet manned space flight effort has become broad, comprehensive, and forward-looking. Their long-running space station program has provided the capabilities to investigate long-term effects of microgravity on human physiology and behavior and test various countermeasures against microgravity-induced physiological deconditioning. Since the beginning of Soviet manned space flight, the biomedical training and preparation of cosmonauts has evolved from a process that increased human tolerance to space flight factors, to a system of interrelated measures to prepare cosmonauts physically and psychologically to live and work in space. Currently, the Soviet Union is constructing a multimodular space station, the Mir. With the emergence of dedicated laboratory modules, the Soviets have begun the transition from small-scale experimental research to large-scale production activities and specialized scientific work in space. In the future, additional laboratory modules will be added, including one dedicated to biomedical research, called the "Medilab." The longest manned space flight to date (326 days) has been completed by the Soviets. The biomedical effects of previous long-duration flights, and perhaps those of still greater length, may contribute important insight ito the possibility of extended missions beyond Earth, such as a voyage to Mars.

Space shuttle orbiter test flight series

NASA Technical Reports Server (NTRS)

Garrett, D.; Gordon, R.; Jackson, R. B.

1977-01-01

The proposed studies on the space shuttle orbiter test taxi runs and captive flight tests were set forth. The orbiter test flights, the approach and landing tests (ALT), and the ground vibration tests were cited. Free flight plans, the space shuttle ALT crews, and 747 carrier aircraft crew were considered.

14 CFR 121.511 - Flight time limitations: Flight engineers: airplanes.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight time limitations: Flight engineers: airplanes. 121.511 Section 121.511 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Operations § 121.511 Flight time limitations: Flight engineers: airplanes. (a) In any operation in which one...

History of Manned Space Flight

NASA Technical Reports Server (NTRS)

1975-01-01

U.S. manned space projects from Mercury Redstone 3 through Skylab 4 are briefly described including dates, flight duration, crew, and number of earth/moon orbits. The flight costs of each project are itemized. Highlights in the history of the manned space program from 1957 to February, 1974 are included.

Kodak Mirror Assembly Tested at Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

2003-01-01

The Eastman-Kodak mirror assembly is being tested for the James Webb Space Telescope (JWST) project at the X-Ray Calibration Facility at Marshall Space Flight Center (MSFC). In this photo, one of many segments of the mirror assembly is being set up inside the 24-ft vacuum chamber where it will undergo x-ray calibration tests. MSFC is supporting Goddard Space Flight Center (GSFC) in developing the JWST by taking numerous measurements to predict its future performance. The tests are conducted in a vacuum chamber cooled to approximate the super cold temperatures found in space. During its 27 years of operation, the facility has performed testing in support of a wide array of projects, including the Hubble Space Telescope (HST), Solar A, Chandra technology development, Chandra High Resolution Mirror Assembly and science instruments, Constellation X-Ray Mission, and Solar X-Ray Imager, currently operating on a Geostationary Operational Environment Satellite. The JWST is NASA's next generation space telescope, a successor to the Hubble Space Telescope, named in honor of NASA's second administrator, James E. Webb. It is scheduled for launch in 2010 aboard an expendable launch vehicle. It will take about 3 months for the spacecraft to reach its destination, an orbit of 940,000 miles in space.

Origin of Marshall Space Flight Center (MSFC)

NASA Image and Video Library

2004-04-15

Twelve scientific specialists of the Peenemuende team at the front of Building 4488, Redstone Arsenal, Huntsville, Alabama. They led the Army's space efforts at ABMA before transfer of the team to National Aeronautic and Space Administration (NASA), George C. Marshall Space Flight Center (MSFC). (Left to right) Dr. Ernst Stuhlinger, Director, Research Projects Office; Dr. Helmut Hoelzer, Director, Computation Laboratory: Karl L. Heimburg, Director, Test Laboratory; Dr. Ernst Geissler, Director, Aeroballistics Laboratory; Erich W. Neubert, Director, Systems Analysis Reliability Laboratory; Dr. Walter Haeussermarn, Director, Guidance and Control Laboratory; Dr. Wernher von Braun, Director Development Operations Division; William A. Mrazek, Director, Structures and Mechanics Laboratory; Hans Hueter, Director, System Support Equipment Laboratory;Eberhard Rees, Deputy Director, Development Operations Division; Dr. Kurt Debus, Director Missile Firing Laboratory; Hans H. Maus, Director, Fabrication and Assembly Engineering Laboratory

Effect of space flight on cytokine production

NASA Astrophysics Data System (ADS)

Sonnenfeld, Gerald

Space flight has been shown to alter many immunological responses. Among those affected are the production of cytokines, Cytokines are the messengers of the immune system that facilitate communication among cells that allow the interaction among cells leading to the development of immune responses. Included among the cytokines are the interferons, interleukins, and colony stimulating factors. Cytokines also facilitate communication between the immune system and other body systems, such as the neuroendocrine and musculoskeletal systems. Some cytokines also have direct protective effects on the host, such as interferon, which can inhibit the replication of viruses. Studies in both humans and animals indicate that models of space flight as well as actual space flight alter the production and action of cytokines. Included among these changes are altered interferon production, altered responsiveness of bone marrow cells to granulocyte/monocyte-colony stimulating factor, but no alteration in the production of interleukin-3. This suggests that there are selective effects of space flight on immune responses, i.e. not all cytokines are affected in the same fashion by space flight. Tissue culture studies also suggest that there may be direct effects of space flight on the cells responsible for cytokine production and action. The results of the above study indicate that the effects of space flight on cytokines may be a fundamental mechanism by which space flight not only affects immune responses, but also other biological systems of the human.

First intramuscular administration in the U.S. space program. [of motion sickness drugs

NASA Technical Reports Server (NTRS)

Bagian, James P.

1991-01-01

In the past, the only kind of medicines used for symptomatic treatment of space motion sickness (SMS) in space had been oral, transdermal, or suppositories. This paper describes the effect of the first intramuscular (IM) administration of Phenergan (50-mg in single dose) on SMS in one subject who exhibited grade-3 symptoms and signs which persisted unabated throughout the first and the second flight days aboard the Space Shuttle. Thirty minutes after the injection, the subject had completely recovered. His symptoms were gone, his appetite was back, and he had no recurrences for the remainder of the flight. Since that experiment, intramuscular injections have been given nine more times on subsequent flights, with similar results.

14 CFR 121.426 - Flight navigators: Initial and transition flight training.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight navigators: Initial and transition flight training. 121.426 Section 121.426 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 121.426 Flight navigators: Initial and transition flight training. Link to an amendment published at...

Immune response during space flight.

PubMed

Criswell-Hudak, B S

1991-01-01

The health status of an astronaut prior to and following space flight has been a prime concern of NASA throughout the Apollo series of lunar landings, Skylab, Apollo-Soyuz Test Projects (ASTP), and the new Spacelab-Shuttle missions. Both humoral and cellular immunity has been studied using classical clinical procedures. Serum proteins show fluctuations that can be explained with adaptation to flight. Conversely, cellular immune responses of lymphocytes appear to be depressed in both in vivo as well as in vitro. If this depression in vivo and in vitro is a result of the same cause, then man's adaptation to outer space living will present interesting challenges in the future. Since the cause may be due to reduced gravity, perhaps the designs of the experiments for space flight will offer insights at the cellular levels that will facilitate development of mechanisms for adaptation. Further, if the aging process is viewed as an adaptational concept or model and not as a disease process then perhaps space flight could very easily interact to supply some information on our biological time clocks.

Results of the Second U.S. Manned Suborbital Space Flight, July 21, 1961

NASA Technical Reports Server (NTRS)

1961-01-01

This document presents the results of the second United States manned suborbital space flight. The data and flight description presented form a continuation of the information provided at an open conference held under the auspices of the National Aeronautics and Space Administration, in cooperation with the National Institutes of Health and the National Academy of Sciences, at the U.S. Department of State Auditorium on June 6, 1961. The papers presented herein generally parallel the presentations of the first report and were prepared by the personnel of the NASA Manned Spacecraft Center in collaboration with personnel from other government agencies, participating industry, and universities. The second successful manned suborbital space flight on July 21, 1961, in which Astronaut Virgil I. Grissom was the pilot was another step in the progressive research, development, and training program leading to the study of man's capabilities in a space environment during manned orbital flight. Data and operational experiences gained from this flight were in agreement with and supplemented the knowledge obtained from the first suborbital flight of May 5, 1961, piloted by Astronaut Alan B. Shepard, Jr. The two recent manned suborbital flights, coupled with the unmanned research and development flights, have provided valuable engineering nd scientific data on which the program can progress. The successful active participation of the pilots, in much the same way as in the development and testing of high performance aircraft, has. greatly increased our confidence in giving man a significant role in future space flight activities. It is the purpose of this report to continue the practice of providing data to the scientific community interested in activities of this nature. Brief descriptions are presented of the Project Mercury spacecraft and flight plan. Papers are provided which parallel the presentations of data published for the first suborbital space flight. Additional

Project Mercury: Man-In-Space Program of the National Aeronautics and Space Administration. [Report of the Committee on Aeronautical and Space Sciences United States Senate

NASA Technical Reports Server (NTRS)

1959-01-01

The purpose of this staff study, made at the request of the chairman, is to serve members of the Committee on Aeronautical and Space Sciences as a source of basic information on Project Mercury, the man-in-space program of the National Aeronautics and Space Administration. The study is largely derived from unclassified information released by the National Aeronautics and Space Administration and testimony concerning Project Mercury given during hearings before this committee. The program descriptions are based upon current program planning. Since this is a highly advanced research and development program, the project is obviously subject to changes that may result from future developments and accomplishments characteristic of such research activities. Certain information with respect to revised schedules, obtained on a classified basis by the committee during inspection trips, is necessarily omitted. The appendixes to the study include information that may prove helpful on various aspects of space flight and exploration. Included are unofficial comments and observations relating to Russia's manned space flight activities and also a complete chronology of all satellites, lunar probes, and space probes up to the present.

Independent verification and validation for Space Shuttle flight software

NASA Technical Reports Server (NTRS)

1992-01-01

The Committee for Review of Oversight Mechanisms for Space Shuttle Software was asked by the National Aeronautics and Space Administration's (NASA) Office of Space Flight to determine the need to continue independent verification and validation (IV&V) for Space Shuttle flight software. The Committee found that the current IV&V process is necessary to maintain NASA's stringent safety and quality requirements for man-rated vehicles. Therefore, the Committee does not support NASA's plan to eliminate funding for the IV&V effort in fiscal year 1993. The Committee believes that the Space Shuttle software development process is not adequate without IV&V and that elimination of IV&V as currently practiced will adversely affect the overall quality and safety of the software, both now and in the future. Furthermore, the Committee was told that no organization within NASA has the expertise or the manpower to replace the current IV&V function in a timely fashion, nor will building this expertise elsewhere necessarily reduce cost. Thus, the Committee does not recommend moving IV&V functions to other organizations within NASA unless the current IV&V is maintained for as long as it takes to build comparable expertise in the replacing organization.

Metabolic and Regulatory Systems in Space Flight

NASA Technical Reports Server (NTRS)

1997-01-01

In this session, Session JP2, the discussion focuses on the following topics: The Dynamics of Blood Biochemical Parameters in Cosmonauts During Long-Term Space Flights; Efficiency of Functional Loading Test for Investigations of Metabolic Responses to Weightlessness; Human Cellular Immunity and Space Flight; Cytokine Production and Head-Down Tilt Bed Rest; Plasma and Urine Amino Acids During Human Space Flight; and DNA Fingerprinting, Applications to Space Microbiology.

Space flight visual simulation.

PubMed

Xu, L

1985-01-01

In this paper, based on the scenes of stars seen by astronauts in their orbital flights, we have studied the mathematical model which must be constructed for CGI system to realize the space flight visual simulation. Considering such factors as the revolution and rotation of the Earth, exact date, time and site of orbital injection of the spacecraft, as well as its orbital flight and attitude motion, etc., we first defined all the instantaneous lines of sight and visual fields of astronauts in space. Then, through a series of coordinate transforms, the pictures of the scenes of stars changing with time-space were photographed one by one mathematically. In the procedure, we have designed a method of three-times "mathematical cutting." Finally, we obtained each instantaneous picture of the scenes of stars observed by astronauts through the window of the cockpit. Also, the dynamic conditions shaded by the Earth in the varying pictures of scenes of stars could be displayed.

Integrating Space Flight Resource Management Skills into Technical Lessons for International Space Station Flight Controller Training

NASA Technical Reports Server (NTRS)

Baldwin, Evelyn

2008-01-01

The Johnson Space Center s (JSC) International Space Station (ISS) Space Flight Resource Management (SFRM) training program is designed to teach the team skills required to be an effective flight controller. It was adapted from the SFRM training given to Shuttle flight controllers to fit the needs of a "24 hours a day/365 days a year" flight controller. More recently, the length reduction of technical training flows for ISS flight controllers impacted the number of opportunities for fully integrated team scenario based training, where most SFRM training occurred. Thus, the ISS SFRM training program is evolving yet again, using a new approach of teaching and evaluating SFRM alongside of technical materials. Because there are very few models in other industries that have successfully tied team and technical skills together, challenges are arising. Despite this, the Mission Operations Directorate of NASA s JSC is committed to implementing this integrated training approach because of the anticipated benefits.

[Ultraviolet radiation and long term space flight].

PubMed

Wu, H B; Su, S N; Ba, F S

2000-08-01

With the prolongation of space flight, influences of various aerospace environmental factors on the astronauts become more and more severe, while ultraviolet radiation is lacking. Some studies indicated that low doses of ultraviolet rays are useful and essential for human body. In space flight, ultraviolet rays can improve the hygienic condition in the space cabin, enhance astronaut's working ability and resistance to unfavorable factors, prevent mineral metabolic disorders, cure purulent skin diseases and deallergize the allergens. So in long-term space flight, moderate amount of ultraviolet rays in the space cabin would be beneficial.

Statistical analysis of flight times for space shuttle ferry flights

NASA Technical Reports Server (NTRS)

Graves, M. E.; Perlmutter, M.

1974-01-01

Markov chain and Monte Carlo analysis techniques are applied to the simulated Space Shuttle Orbiter Ferry flights to obtain statistical distributions of flight time duration between Edwards Air Force Base and Kennedy Space Center. The two methods are compared, and are found to be in excellent agreement. The flights are subjected to certain operational and meteorological requirements, or constraints, which cause eastbound and westbound trips to yield different results. Persistence of events theory is applied to the occurrence of inclement conditions to find their effect upon the statistical flight time distribution. In a sensitivity test, some of the constraints are varied to observe the corresponding changes in the results.

Human Space Flight Plans Committee

NASA Image and Video Library

2009-06-16

Norman Augustine, chair of the Human Space Flight Review Committee, makes a point during the first of several public meetings at different U.S. locations, Wednesday, June 17, 2009, at the Carnegie Institution in Washington. The panel will examine ongoing and planned NASA development activities and potential alternatives in order to present options for advancing a safe, innovative, affordable and sustainable human space flight program following the space shuttle's retirement. The committee wil present its results by August 2009. Photo Credit: (NASA/Paul E. Alers)

Metabolic energy requirements for space flight

NASA Technical Reports Server (NTRS)

Lane, Helen W.

1992-01-01

The international space community, including the USSR, Japan, Germany, the European Space Agency, and the US, is preparing for extended stays in space. Much of the research planned for space will be tended by humans, thus, maintaining adequate nutritional status during long stays in space has lately become an issue of much interest. Historically, it appears that minimum nutritional requirements are being met during stays in space. Thus far, crewmembers have been able to consume food adequate for maintaining nominal performance in microgravity. The physiological data obtained from ground-based and flight research that may enable us to understand the biochemical alterations that effect energy utilization and performance. Focus is on energy utilization during the Apollo lunar missions, Skylab's extended space lab missions, and Space Shuttle flights. Available data includes those recorded during intra- and extravehicular activities as well as during microgravity simulation (bed rest). Data on metabolism during flight and during bed rest are discussed, with a follow-up on human gastrointestinal function.

How human sleep in space — investigations during space flights

NASA Astrophysics Data System (ADS)

Stoilova, I. M.; Zdravev, T. K.; Yanev, T. K.

Sleep problems have been observed during many of the space flights. The existence of poor quality of sleep, fatigue, insomnia or different alterations in sleep structure, organization and sleep cyclicity have been established. Nevertheless results obtained from investigations of human sleep on board manned space vehicles show that it is possible to keep sleep patterns related to the restorative and adaptive processes. For the first time in the frame of the "Intercosmos" program a multi-channel system for recording and analysis of sleep in space was constructed by scientists of the Bulgarian Academy of Sciences and was installed on board the manned Mir orbiting station. In 1988 during the joint Bulgarian-Russian space flight continues recording of electro-physiological parameters necessary to estimate the sleep stages and sleep organization was made. These investigations were continued in next space flights of different prolongation. The results were compared with the findings obtained under the conditions during the pre- and post-flight periods.

Challenges of Human Space Flight

NASA Technical Reports Server (NTRS)

Davis, Jeffrey R.; Charles, John B.

2006-01-01

The presentations will be given during the X-Prize symposium, exploring the multi-faceted dimensions of spaceflight ranging from the technical developments necessary to achieve safe routine flight to and from and through space to the new personal business opportunities and economic benefits that will open in space and here on Earth. The symposium will delve into the technical, regulatory, market and financial needs and challenges that must be met in charting and executing the incremental developments leading to Personal Spaceflight and the opening of a Place Called Space. The presentation covers facets of human space flight including descriptions of life in space, the challenges of delivering medical care in space, and the preparations needed for safe and productive human travel to the moon and Mars.

Comparing future options for human space flight

NASA Astrophysics Data System (ADS)

Sherwood, Brent

2011-09-01

The paper analyzes the "value proposition" for government-funded human space flight, a vexing question that persistently dogs efforts to justify its $10 10/year expense in the US. The original Mercury/Gemini/Apollo value proposition is not valid today. Neither was it the value proposition actually promoted by von Braun, which the post-Apollo 80% of human space flight history has persistently attempted to fulfill. Divergent potential objectives for human space flight are captured in four strategic options— Explore Mars; accelerate Space Passenger Travel; enable Space Power for Earth; and Settle the Moon—which are then analyzed for their purpose, societal myth, legacy benefits, core needs, and result as measured by the number and type of humans they would fly in space. This simple framework is proposed as a way to support productive dialog with public and other stakeholders, to determine a sustainable value proposition for human space flight.

Orbiter Enterprise at Marshall Space Flight Center for testing

NASA Image and Video Library

2002-10-29

In this view, the Shuttle Orbiter Enterprise is seen heading South on Rideout Road with Marshall Space Flight Center's (MSFC'S) administrative 4200 Complex in the background, as it is being transported to MSFC's building 4755 for later Mated Vertical Ground Vibration tests (MVGVT) at MSFC's Dynamic Test Stand. The tests marked the first time ever that the entire shuttle complement (including Orbiter, external tank, and solid rocket boosters) were mated vertically.

Human tolerance to space flight

NASA Technical Reports Server (NTRS)

Huntoon, C. L.

1989-01-01

Medical studies of astronauts and cosmonauts before, during, and after space missions have identified several effects of weightlessness and other factors that influence the ability of humans to tolerate space flight. Weightlessness effects include space motion sickness, cardiovascular abnormalities, reduction in immune system function, loss of red blood cells, loss of bone mass, and muscle atrophy. Extravehicular activity (EVA) increases the likelihood that decompression sickness may occur. Radiation also gives reason for concern about health of crewmembers, and psychological factors are important on long-term flights. Countermeasures that have been used include sensory preadaptation, prebreathing and use of various air mixtures for EVA, loading with water and electrolytes, exercise, use of pharmacological agents and special diets, and psychological support. It appears that humans can tolerate and recover satisfactorily from at least one year of space flight, but a number of conditions must be further ameliorated before long-duration missions can be considered routine.

Human Space Flight Plans Committee

NASA Image and Video Library

2009-06-16

Norman Augustine, chair of the Human Space Flight Review Committee, listens to a comment from the audience during the first of several public meetings at different U.S. locations, Wednesday, June 17, 2009, at the Carnegie Institution in Washington. The panel will examine ongoing and planned NASA development activities and potential alternatives in order to present options for advancing a safe, innovative, affordable and sustainable human space flight program following the space shuttle's retirement. The committee wil present its results by August 2009. Photo Credit: (NASA/Paul E. Alers)

Predictors of immune function in space flight

NASA Astrophysics Data System (ADS)

Shearer, William T.; Zhang, Shaojie; Reuben, James M.; Lee, Bang-Ning; Butel, Janet S.

2007-02-01

Of all of the environmental conditions of space flight that might have an adverse effect upon human immunity and the incidence of infection, space radiation stands out as the single-most important threat. As important as this would be on humans engaged in long and deep space flight, it obviously is not possible to plan Earth-bound radiation and infection studies in humans. Therefore, we propose to develop a murine model that could predict the adverse effects of space flight radiation and reactivation of latent virus infection for humans. Recent observations on the effects of gamma and latent virus infection demonstrate latent virus reactivation and loss of T cell mediated immune responses in a murine model. We conclude that using this small animal method of quantitating the amounts of radiation and latent virus infection and resulting alterations in immune responses, it may be possible to predict the degree of immunosuppression in interplanetary space travel for humans. Moreover, this model could be extended to include other space flight conditions, such as microgravity, sleep deprivation, and isolation, to obtain a more complete assessment of space flight risks for humans.

Comparing Future Options for Human Space Flight

NASA Technical Reports Server (NTRS)

Sherwood, Brent

2010-01-01

The paper analyzes the "value proposition" for government-funded human space flight, a vexing question that persistently dogs efforts to justify its $10(exp 10)/year expense in the U.S. The original Mercury/Gemini/Apollo value proposition is not valid today. Neither was it the value proposition actually promoted by von Braun, which the post-Apollo 80% of human space flight history has persistently attempted to fulfill. Divergent potential objectives for human space flight are captured in four strategic options - Explore Mars; accelerate Space Passenger Travel; enable Space Power for Earth; and Settle the Moon - which are then analyzed for their Purpose, societal Myth, Legacy benefits, core Needs, and result as measured by the number and type of humans they would fly in space. This simple framework is proposed as a way to support productive dialogue with public and other stakeholders, to determine a sustainable value proposition for human space flight.

Advanced Fiber-optic Monitoring System for Space-flight Applications

NASA Technical Reports Server (NTRS)

Hull, M. S.; VanTassell, R. L.; Pennington, C. D.; Roman, M.

2005-01-01

Researchers at Luna Innovations Inc. and the National Aeronautic and Space Administration s Marshall Space Flight Center (NASA MSFC) have developed an integrated fiber-optic sensor system for real-time monitoring of chemical contaminants and whole-cell bacterial pathogens in water. The system integrates interferometric and evanescent-wave optical fiber-based sensing methodologies with atomic force microscopy (AFM) and long-period grating (LPG) technology to provide versatile measurement capability for both micro- and nano-scale analytes. Sensors can be multiplexed in an array format and embedded in a totally self-contained laboratory card for use with an automated microfluidics platform.

Space Flight Support Building

NASA Image and Video Library

2016-10-27

This archival image was released as part of a gallery comparing JPL’s past and present, commemorating the 80th anniversary of NASA’s Jet Propulsion Laboratory on Oct. 31, 2016. Building 264, also known as the Space Flight Support Building, hosts engineers supporting space missions in flight at NASA's Jet Propulsion Laboratory. It used to be just two stories, as seen in this image from January 1972, but then the Viking project to Mars needed more room. The building still serves the same function today, but now has eight floors. http://photojournal.jpl.nasa.gov/catalog/PIA21123

Cardiovascular function in space flight

NASA Technical Reports Server (NTRS)

Nicogossian, A. E.; Charles, J. B.; Bungo, M. W.; Leach-Huntoon, C. S.

1990-01-01

Postflight orthostatic intolerance and cardiac hemodynamics associated with manned space flight have been investigated on seven STS missions. Orthostatic heart rates appear to be influenced by the mission duration. The rates increase during the first 7-10 days of flight and recover partially after that. Fluid loading is used as a countermeasure to the postflight orthostatic intolerance. The carotid baroreceptor function shows only slight responsiveness to orthostatic stimulation. Plots of the baroreceptor function are presented. It is concluded that an early adaptation to the space flight conditions involves a fluid shift and that the subsequent alterations in the neutral controlling mechanisms contribute to the orthoststic intolerance.

Design considerations for space flight hardware

NASA Technical Reports Server (NTRS)

Glover, Daniel

1990-01-01

The environmental and design constraints are reviewed along with some insight into the established design and quality assurance practices that apply to low earth orbit (LEO) space flight hardware. It is intended as an introduction for people unfamiliar with space flight considerations. Some basic data and a bibliography are included.

Effects of space flight on surface marker expression

NASA Astrophysics Data System (ADS)

Sonnenfeld, G.

1999-01-01

Space flight has been shown to affect expression of several cell surface markers. These markers play important roles in regulation of immune responses, including CD4 and CD8. The studies have involved flight of experimental animals and humans followed by analysis of tissue samples (blood in humans, rats and monkeys, spleen, thymus, lymph nodes and bone marrow in rodents). The degree and direction of the changes induced by space flight have been determined by the conditions of the flight. Also, there may be compartmentalization of the response of surface markers to space flight, with differences in the response of cells isolated from blood and local immune tissue. The same type of compartmentalization was also observed with cell adhesion molecules (integrins). In this case, the expression of integrins from lymph node cells differed from that of splenocytes isolated from rats immediately after space flight. Cell culture studies have indicated that there may be an inhibition in conversion of a precursor cell line to cells exhibiting mature macrophage characteristics after space flight, however, these experiments were limited as a result of technical difficulties. In general, it is clear that space flight results in alterations of cell surface markers. The biological significance of these changes remains to be established.

Role of Corticosteroids in Bone Loss During Space Flight

NASA Technical Reports Server (NTRS)

Wronski, Thomas J.; Halloran, Bernard P.; Miller, Scott C.

1998-01-01

The primary objective of this research project is to test the hypothesis that corticosteroids contribute to the adverse skeletal effects of space flight. To achieve this objective, serum corticosteroids, which are known to increase during space flight, must be maintained at normal physiologic levels in flight rats by a combination of adrenalectomy and corticosteroid supplementation via implanted hormone pellets. Bone analyses in these animals will then be compared to those of intact flight rats that, based on past experience, will undergo corticosteroid excess and bone loss during space flight. The results will reveal whether maintaining serum corticosteroids at physiologic levels in flight rats affects the skeletal abnormalities that normally develop during space flight. A positive response to this question would indicate that the bone loss and decreased bone formation associated with space flight are mediated, at least in part, by corticosteroid excess.

Mouse infection models for space flight immunology

NASA Technical Reports Server (NTRS)

Chapes, Stephen Keith; Ganta, Roman Reddy; Chapers, S. K. (Principal Investigator)

2005-01-01

Several immunological processes can be affected by space flight. However, there is little evidence to suggest that flight-induced immunological deficits lead to illness. Therefore, one of our goals has been to define models to examine host resistance during space flight. Our working hypothesis is that space flight crews will come from a heterogeneous population; the immune response gene make-up will be quite varied. It is unknown how much the immune response gene variation contributes to the potential threat from infectious organisms, allergic responses or other long term health problems (e.g. cancer). This article details recent efforts of the Kansas State University gravitational immunology group to assess how population heterogeneity impacts host health, either in laboratory experimental situations and/or using the skeletal unloading model of space-flight stress. This paper details our use of several mouse strains with several different genotypes. In particular, mice with varying MHCII allotypes and mice on the C57BL background with different genetic defects have been particularly useful tools with which to study infections by Staphylococcus aureus, Salmonella typhimurium, Pasteurella pneumotropica and Ehrlichia chaffeensis. We propose that some of these experimental challenge models will be useful to assess the effects of space flight on host resistance to infection.

Atmospheric reentry flight test of winged space vehicle

NASA Astrophysics Data System (ADS)

Inatani, Yoshifumi; Akiba, Ryojiro; Hinada, Motoki; Nagatomo, Makoto

A summary of the atmospheric reentry flight experiment of winged space vehicle is presented. The test was conducted and carried out by the Institute of Space and Astronautical Science (ISAS) in Feb. 1992 in Kagoshima Space Center. It is the first Japanese atmospheric reentry flight of the controlled lifting vehicle. A prime objective of the flight is to demonstrate a high speed atmospheric entry flight capability and high-angle-of-attack flight capability in terms of aerodynamics, flight dynamics and flight control of these kind of vehicles. The launch of the winged vehicle was made by balloon and solid propellant rocket booster which was also the first trial in Japan. The vehicle accomplishes the lfight from space-equivalent condition to the atmospheric flight condition where reaction control system (RCS) attitude stabilization and aerodynamic control was used, respectively. In the flight, the vehicle's attitude was measured by both an inertial measurement unit (IMU) and an air data sensor (ADS) which were employed into an auto-pilot flight control loop. After completion of the entry transient flight, the vehicle experienced unexpected instability during the atmospheric decelerating flight; however, it recovered the attitude orientation and completed the transonic flight after that. The latest analysis shows that it is due to the ADS measurement error and the flight control gain scheduling; what happened was all understood. Some details of the test and the brief summary of the current status of the post flight analysis are presented.

Bone and Calcium Metabolism During Space Flight

NASA Technical Reports Server (NTRS)

Smith, Scott M.

2004-01-01

Understanding bone loss during space flight is one of the most critical challenges for maintaining astronaut health on space exploration missions. Flight and ground-based studies have been conducted to better understand the nature and mechanisms of weightlessness-induced bone loss, and to identify a means to counteract the loss. Maintenance of bone health requires a balance between bone formation and bone resorption. Early space research identified bone loss as a critical health issue, but could not provide a distinction between the bone formation and breakdown processes. The recent identification of collagen crosslinks as markers of bone resorption has made possible a clear understanding that a decrease in bone resorption is an important effect of space flight, with bone formation being unchanged or only slightly decreased. Calcium regulatory factors have also been studied, in an attempt to understand their role in bone loss. The lack of ultraviolet light exposure and insufficient dietary sources of vitamin D often lead to reduced vitamin D stores on long-duration flights. Serum parathyroid hormone (PTH) concentrations are decreased during flight compared to before flight, although small subject numbers often make this hard to document statistically. As expected, reduced PTH concentrations are accompanied by reduced 1,25-dihydroxyvitamin D concentrations. Calcium kinetic studies during space flight confirm and extend the information gained from biochemical markers of bone metabolism. Calcium kinetic studies demonstrate that bone resorption is increased, bone formation is unchanged or decreased, and dietary calcium absorption is reduced during space flight. Evaluations have also been conducted of countermeasures, including dietary, exercise, and pharmacological treatments. In recent studies, many potential countermeasures show promise at mitigating bone loss in ground-based analogs of weightlessness (e.g., bed rest), but require further ground and flight testing to

Human Space Flight Plans Committee

NASA Image and Video Library

2009-06-16

U.S. Sen. Bill Nelson, D-Fla., at podium, addresses members of the Human Space Flight Review Committee, Wednesday, June 17, 2009, at the Carnegie Institution in Washington. Seated from left are Jeffrey Greason, Bohdan Bejmuk, Dr. Leroy Chiao, Norman Augustine (chair), Dr. Wanda Austin, Dr. Edward Crawley, Dr. Christopher Chyba and Philip McAlister. The panel will examine ongoing and planned NASA development activities and potential alternatives in order to present options for advancing a safe, innovative, affordable and sustainable human space flight program following the space shuttle's retirement. The committee wil present its results by August 2009. Photo Credit: (NASA/Paul E. Alers)

Effects of Space Flight on Rodent Tissues

NASA Technical Reports Server (NTRS)

Worgul, Basil V.

1997-01-01

As the inevitable expression of mankind's search for knowledge continues into space, the potential acute and long-term effects of space flight on human health must be fully appreciated. Despite its critical role relatively little is known regarding the effects of the space environment on the ocular system. Our proposed studies were aimed at determining whether or not space flight causes discernible disruption of the genomic integrity, cell kinetics, cytoarchitecture and other cytological parameters in the eye. Because of its defined and singular biology our main focus was on the lens and possible changes associated with its primary pathology, cataract. We also hoped to explore the possible effect of space flight on the preferred orientation of dividing cells in the perilimbal region of conjunctiva and cornea.

Bronchoesophageal and related systems in space flight

NASA Technical Reports Server (NTRS)

Thornton, William

1991-01-01

A review is presented of the detrimental effects of space flight on the human bronchoesophageal system emphasizing related areas such as the gastric system. In-flight symptoms are listed including congestion, nasopharyngeal irritation, epigastric sensations, anorexia, and nausea. Particular attention is given to space-related effects on eating/drinking associated with the absence of hydrostatic pressure in the vascular system. The atmospheric characteristics of a typical space shuttle flight are given, and the reduced pressure and low humidity are related to bronchial, eye, and nose irritation. Earth and space versions of motion sickness are compared, and some critical differences are identified. It is proposed that more research is required to assess the effects of long-duration space travel on these related systems.

ACES: Space shuttle flight software analysis expert system

NASA Technical Reports Server (NTRS)

Satterwhite, R. Scott

1990-01-01

The Analysis Criteria Evaluation System (ACES) is a knowledge based expert system that automates the final certification of the Space Shuttle onboard flight software. Guidance, navigation and control of the Space Shuttle through all its flight phases are accomplished by a complex onboard flight software system. This software is reconfigured for each flight to allow thousands of mission-specific parameters to be introduced and must therefore be thoroughly certified prior to each flight. This certification is performed in ground simulations by executing the software in the flight computers. Flight trajectories from liftoff to landing, including abort scenarios, are simulated and the results are stored for analysis. The current methodology of performing this analysis is repetitive and requires many man-hours. The ultimate goals of ACES are to capture the knowledge of the current experts and improve the quality and reduce the manpower required to certify the Space Shuttle onboard flight software.

Investigation of periodontal tissue during a long space flights

NASA Astrophysics Data System (ADS)

Solovyeva, Zoya; Viacheslav, Ilyin; Skedina, Marina

Previous studies conducted on the International Space Station found that upon completion of the space flight there are significant changes in the local immunity and periodontal microflora of astronauts. Also research in ground-based experiments that simulate space flight factors showed that prolonged hypokinesia antiorthostatic leads to impaired functional indicators of the periodontal vascular system, an unidirectional change from the microbiota and the immune system. That results in the appearance and progressive increase of the parodontial pathogenic bacteria and increase of the content of immunoglobulins in the oral fluid. All these changes are classified as risk factors for the development of inflammatory periodontal diseases in astronauts. However, the studies were unable to determine whether the changes result from a long space flight and the peculiarities of formation the local immunity and periodontal microbiota during the space flight, or they are one of the specific manifestations of the readaptationary post-flight condition of the body. In this regard, the planned research in a long space flight suggests: to use the means of microbial control, which can retain of the anaerobes periodontal microbiota sampling directly in the space flight; to assess the specificity of changes of the periodontal immune status under the influence of the space flight factors, and to assess the state of microcirculation of periodontal tissue in astronauts. A comprehensive study of the reaction of dentition during the space flight will make it possible to study the pathogenesis of changes for developing an adequate prevention aimed at optimizing the state of dentition of the astronauts.

Space Flight Cable Model Development

NASA Technical Reports Server (NTRS)

Spak, Kaitlin

2013-01-01

This work concentrates the modeling efforts presented in last year's VSGC conference paper, "Model Development for Cable-Harnessed Beams." The focus is narrowed to modeling of space-flight cables only, as a reliable damped cable model is not yet readily available and is necessary to continue modeling cable-harnessed space structures. New experimental data is presented, eliminating the low-frequency noise that plagued the first year's efforts. The distributed transfer function method is applied to a single section of space flight cable for Euler-Bernoulli and shear beams. The work presented here will be developed into a damped cable model that can be incorporated into an interconnected beam-cable system. The overall goal of this work is to accurately predict natural frequencies and modal damping ratios for cabled space structures.

Research and technology, 1984: Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Moorehead, T. W. (Editor)

1984-01-01

The Marshall Space Flight Center conducts research programs in space sciences, materials processing in space, and atmospheric sciences, as well as technology programs in such areas as propulsion, materials, processes, and space power. This Marshall Space Flight Center 1984 Annual Report on Research and Technology contains summaries of the more significant scientific and technical results obtained during FY-84.

NASA - Human Space Flight

NASA Technical Reports Server (NTRS)

Davis, Jeffrey R.

2006-01-01

The presentation covers five main topical areas. The first is a description of how things work in the microgravity environment such as convection and sedimentation. The second part describes the effects of microgravity on human physiology. This is followed by a description of the hazards of space flight including the environment, the space craft, and the mission. An overview of biomedical research in space, both on shuttle and ISS is the fourth section of the presentation. The presentation concludes with a history of space flight from Ham to ISS. At CART students (11th and 12th graders from Fresno Unified and Clovis Unified) are actively involved in their education. They work in teams to research real world problems and discover original solutions. Students work on projects guided by academic instructors and business partners. They will have access to the latest technology and will be expected to expand their learning environment to include the community. They will focus their studies around a career area (Professional Sciences, Advanced Communications, Engineering and Product Development, or Global Issues).

Calcium Kinetics During Long-Duration Space Flight

NASA Technical Reports Server (NTRS)

Smith, Scott M.; OBrien, K. O.; Wastney, M. E.; Morukov, B. V.; Larina, I.; Abrams, S. A.; Lane, H. W.; Nillen, J. L.; Davis-Street, J. E.; Oganov, V.;

Research and Technology, 1987, Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Guerny, Gene (Editor); Moe, Karen (Editor); Paddack, Steven (Editor); Soffen, Gerald (Editor); Sullivan, Walter (Editor); Ballard, Jan (Editor)

1987-01-01

Research at Goddard Space Flight Center during 1987 is summarized. Topics addressed include space and earth sciences, technology, flight projects and mission definition studies, and institutional technology.

Vision Aspects of Space Flight

NASA Technical Reports Server (NTRS)

Manuel, Keith; Billica, Roger (Technical Monitor)

2000-01-01

Vision, being one of our most important senses, is critically important in the unique working environment of space flight. Critical evaluation of the astronauts visual system begins with pre-selection examinations resulting in an average of 65% of all medical disqualification's caused by ocular findings. With an average age of 42, approximately 60% of the astronaut corps requires vision correction. Further demands of the unique training and working environment of microgravity, variable lighting from very poor to extreme brightness of sunlight and exposure to extremes of electromagnetic energy results in unique eyewear and contact lens applications. This presentation will describe some of those unique eyewear and contact lens applications used in space flight and training environments. Additionally, ocular findings from 26 shuttle and 5 MIR mission post-flight examinations will be presented.

Skylab rescue space vehicle flight readiness test

NASA Technical Reports Server (NTRS)

Jevitt, S. J.

1973-01-01

A Skylab Rescue Space Vehicle flight readiness test is described which ensures that space vehicle systems are in a state of flight readiness and are compatible with associated ground support equipment. The functions of propellant loading, umbilical ejection, ignition, holddown arm release, liftoff, and service arm and tail service mast retraction are simulated. The test outline is presented along with a list of references, intercommunications information, operations interface control chart, and flight test.

Visual-Vestibular Responses During Space Flight

NASA Technical Reports Server (NTRS)

Reschke, M. F.; Kozlovskaya, I. B.; Paloski, W. H.

1999-01-01

Given the documented disruptions that occur in spatial orientation during space flight and the putative sensory-motor information underlying eye and head spatial coding, the primary purpose of this paper is to examine components of the target acquisition system in subjects free to make head and eye movements in three dimensional space both during and following adaptation to long duration space flight. It is also our intention to suggest a simple model of adaptation that has components in common with cerebellar disorders whose neurobiological substrate has been identified.

Environmental Assessment for Flight Test to the Edge of Space

DTIC Science & Technology

2008-12-22

1508); 32 CFR Part 989, Environmental Impact Analysis Process; and National Aeronautics and Space Administration ( NASA ) policy and procedures (14 CFR...Part 1216, Subpart 1216.3). The U.S. Air Force Flight Test Center is representing the Department of Defense (DOD) as the lead agency. NASA Dryden...Kansas, Nebraska, South Dakota, and North Dakota; and-land at Edwards AFB. These vehicles could be launched from any DOD or NASA installation or from

The Texas space flight liability act and efficient regulation for the private commercial space flight era

NASA Astrophysics Data System (ADS)

Johnson, Christopher D.

2013-12-01

In the spring of 2011, the American state of Texas passed into law an act limiting the liability of commercial space flight entities. Under it, those companies would not be liable for space flight participant injuries, except in cases of intentional injury or injury proximately caused by the company's gross negligence. An analysis within the framework of international and national space law, but especially informed by the academic discipline of law and economics, discusses the incentives of all relevant parties and attempts to understand whether the law is economically "efficient" (allocating resources so as to yield maximum utility), and suited to further the development of the fledgling commercial suborbital tourism industry. Insights into the Texas law are applicable to other states hoping to foster commercial space tourism and considering space tourism related legislation.

Effects of the space flight environment on the immune system

NASA Technical Reports Server (NTRS)

Sonnenfeld, Gerald; Butel, Janet S.; Shearer, William T.

2003-01-01

Space flight conditions have a dramatic effect on a variety of physiologic functions of mammals, including muscle, bone, and neurovestibular function. Among the physiological functions that are affected when humans or animals are exposed to space flight conditions is the immune response. The focus of this review is on the function of the immune system in space flight conditions during actual space flights, as well as in models of space flight conditions on the earth. The experiments were carried out in tissue culture systems, in animal models, and in human subjects. The results indicate that space flight conditions alter cell-mediated immune responses, including lymphocyte proliferation and subset distribution, and cytokine production. The mechanism(s) of space flight-induced alterations in immune system function remain(s) to be established. It is likely, however, that multiple factors, including microgravity, stress, neuroendocrine factors, sleep disruption, and nutritional factors, are involved in altering certain functions of the immune system. Such alterations could lead to compromised defenses against infections and tumors.

14 CFR 437.39 - Flight rules.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Flight rules. 437.39 Section 437.39 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Documentation § 437.39 Flight rules. An applicant must provide flight rules as required by § 437.71. ...

14 CFR 437.39 - Flight rules.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Flight rules. 437.39 Section 437.39 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Documentation § 437.39 Flight rules. An applicant must provide flight rules as required by § 437.71. ...

14 CFR 437.39 - Flight rules.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Flight rules. 437.39 Section 437.39 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Documentation § 437.39 Flight rules. An applicant must provide flight rules as required by § 437.71. ...

14 CFR 437.39 - Flight rules.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Flight rules. 437.39 Section 437.39 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Documentation § 437.39 Flight rules. An applicant must provide flight rules as required by § 437.71. ...

14 CFR 437.39 - Flight rules.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Flight rules. 437.39 Section 437.39 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Documentation § 437.39 Flight rules. An applicant must provide flight rules as required by § 437.71. ...

International Space Station medical standards and certification for space flight participants.

PubMed

Bogomolov, Valery V; Castrucci, Filippo; Comtois, Jean-Marc; Damann, Volker; Davis, Jeffrey R; Duncan, J Michael; Johnston, Smith L; Gray, Gary W; Grigoriev, Anatoly I; Koike, Yu; Kuklinski, Paul; Matveyev, Vladimir P; Morgun, Valery V; Pochuev, Vladimir I; Sargsyan, Ashot E; Shimada, Kazuhito; Straube, Ulrich; Tachibana, Shoichi; Voronkov, Yuri V; Williams, Richard S

2007-12-01

The medical community of the International Space Station (ISS) has developed joint medical standards and evaluation requirements for Space Flight Participants ("space tourists") which are used by the ISS medical certification board to determine medical eligibility of individuals other than professional astronauts (cosmonauts) for short-duration space flight to the ISS. These individuals are generally fare-paying passengers without operational responsibilities. By means of this publication, the medical standards and evaluation requirements for the ISS Space Flight Participants are offered to the aerospace medicine and commercial spaceflight communities for reference purposes. It is emphasized that the criteria applied to the ISS spaceflight participant candidates are substantially less stringent than those for professional astronauts and/or crewmembers of visiting and long-duration missions to the ISS. These medical standards are released by the government space agencies to facilitate the development of robust medical screening and medical risk assessment approaches in the context of the evolving commercial human spaceflight industry.

Impact of space flight on cardiovascular autonomic control

NASA Astrophysics Data System (ADS)

Beckers, F.; Verheyden, B.; Morukov, B.; Aubert, Ae

Introduction: Space flight alters the distribution of blood in the human body, leading to altered cardiovascular neurohumoral regulation with a blunted carotid-cardiac baroreflex. These changes contribute to the occurrence of orthostatic intolerance after space flight. Heart rate variability (HRV) and blood pressure variability (BPV) provide non-invasive means to study the autonomic modulation of the heart. Low frequency (LF) oscillations provide information about sympathetic modulation and baroreflex, while high frequency (HF) modulation is an index of vagal heart rate modulation. Methods: ECG and continuous blood pressure were measured for at least 10 minutes in supine, sitting and standing position 45 days and 10 days (L-45, L-10) before launch; and at 1, 2, 4, 9, 15, 19 and 25 days after return to earth (R+x). In space, ECG and continuous blood pressure were measured at day 5 (FD5) and day 8 (FD8). These measurements were performed in 3. HRV and BPV indices were calculated in time and frequency domain. Results: Measurements in supine position and sitting position did not show as high differences as the measurements in standing position. During space flight heart rate was significantly lower compared to the pre- and post-flight measurements in standing position (RR-values: L-45: 837± 42 ms; FD5: 1004± 40 ms; FD8: 1038± 53 ms; R+1: 587± 21 ms; p<0.05). This was accompanied by a significant increase in the proportion of HF power during space flight and a decrease in LF power. Immediately after space flight both LF and HF modulation of heart rate were extremely depressed compared to the pre-flight conditions (p<0.005). A gradual recovery towards baseline conditions of both indices was observed up to 25 days after return from space (LF: L-45: 3297± 462 ms2; FD5: 1251± 332 ms2; FD8: 1322± 462 ms2; R+1: 547± 188 ms2; R+4: 1958± 709 ms2; R+9: 1220± 148 ms2; R+15: 1704± 497 ms2; R+25: 2644± 573 ms2). However, even 25 days after return, values were below

Cardiovascular function in space flight

NASA Astrophysics Data System (ADS)

Nicgossian, A. E.; Charles, J. B.; Bungo, M. W.; Leach-Huntoon, C. S.

Changes in orthostatic heart rate have been noted universally in Soviet and U.S. crewmembers post space flight. The magnitude of these changes appears to be influenced by mission duration, with increasing orthostatic intolerance for the first 7-10 days of flight and then a partial recovery in the orthostatic heart rate response. Fluid loading has been used as a countermeasure to this postflight orthostatic intolerance. Previous reports have documented the effectiveness of this technique, but it has also been noted that the effectiveness of volume expansion diminishes as flight duration exceeds one week. The response of carotid baroreceptor function was investigated utilizing a commercially available neck collar which could apply positive and negative pressure to effect receptor stimulation. Bedrest studies had validated the usefulness and validity of the device. In these studies it was shown that carotid baroreceptor function curves demonstrated less responsiveness to orthostatic stimulation than control individuals. Twelve Space Shuttle crewmembers were examined pre- and postflight from flights lasting from 4-5 days. Plots of baroreceptor function were constructed and plotted as change in R-R interval vs. carotid distending pressure (an orthostatic stimulus). Typical sigmoidal curves were obtained. Postflight the resting heart rate was higher (smaller R-R interval) and the range of R-R value and the slope of the carotid sigmoidal response were both depressed. These changes were not significant immediately postflight (L+O), but did become significant by the second day postflight (L+2), and remained suppressed for several days thereafter. It is hypothesized that the early adaptation to space flight involves a central fluid shift during the initial days of flight, but subsequent alterations in neural controlling mechanisms (such as carotid baroreceptor function) contribute to orthostatic intolerance.

Cardiovascular function in space flight

NASA Technical Reports Server (NTRS)

Nicogossian, A. E.; Charles, J. B.; Bungo, M. W.; Leach-Huntoon, C. S.; Nicgossian, A. E.

1991-01-01

Changes in orthostatic heart rate have been noted universally in Soviet and U.S. crewmembers post space flight. The magnitude of these changes appears to be influenced by mission duration, with increasing orthostatic intolerance for the first 7-10 days of flight and then a partial recovery in the orthostatic heart rate response. Fluid loading has been used as a countermeasure to this postflight orthostatic intolerance. Previous reports have documented the effectiveness of this technique, but it has also been noted that the effectiveness of volume expansion diminishes as flight duration exceeds one week. The response of carotid baroreceptor function was investigated utilizing a commercially available neck collar which could apply positive and negative pressure to effect receptor stimulation. Bedrest studies had validated the usefulness and validity of the device. In these studies it was shown that carotid baroreceptor function curves demonstrated less responsiveness to orthostatic stimulation than control individuals. Twelve Space Shuttle crewmembers were examined pre- and postflight from flights lasting from 4-5 days. Plots of baroreceptor function were constructed and plotted as change in R-R interval vs. carotid distending pressure (an orthostatic stimulus). Typical sigmoidal curves were obtained. Postflight the resting heart rate was higher (smaller R-R interval) and the range of R-R value and the slope of the carotid sigmoidal response were both depressed. These changes were not significant immediately postflight (L + O), but did become significant by the second day postflight (L + 2), and remained suppressed for several days thereafter. It is hypothesized that the early adaptation to space flight involves a central fluid shift during the initial days of flight, but subsequent alterations in neural controlling mechanisms (such as carotid baroreceptor function) contribute to orthostatic intolerance.

Integration Testing of Space Flight Systems

NASA Technical Reports Server (NTRS)

Sowards, Stephanie; Honeycutt, Timothy

2008-01-01

This paper discusses the benefits of conducting multi-system integration testing of space flight elements in lieu of merely shipping and shooting to the launch site and launching. "Ship and shoot" is a philosophy that proposes to transport flight elements directly from the factory to the launch site and begin the mission without further testing. Integration testing, relevant to validation testing in this context, is a risk mitigation effort that builds upon the individual element and system levels of qualification and acceptance tests, greatly improving the confidence of operations in space. The International Space Station Program (ISSP) experience is the focus of most discussions from a historical perspective, while proposed integration testing of the Constellation Program is also discussed. The latter will include Multi-Element Integration Testing (MElT) and Flight Element Integration Testing (FElT).

Obtaining NASA Approval for use of Non-Metallic Materials in Manned Space Flight

NASA Technical Reports Server (NTRS)

Davis, Samuel E.; Wise, Harry L.

2003-01-01

Material manufacturers and suppliers are often surprised when a material commonly provided to industry is not approved for use on manned spacecraft. Often the reason is a lack of test data in environments that simulate those encountered in space applications, especially oxygen-enriched conditions, which significantly increase both the likelihood of material combustion and the propagation of a fire. This paper introduces the requirements for flight approval of non-metallic materials, focusing on material testing for human-rated space flight programs; it reviews the history of flight materials requirements and provides the rationale for such and introduces specific requirements related to testing and to good material engineering and design practices. After describing the procedure for submitting materials to be tested, the paper outlines options available if a material fails testing. In addition, this treatise introduces the National Aeronautics and Space Administration's (NASA's) Materials and Processes Technical Information System (MAPTIS), a database housing all test data produced in accordance with NASA-STD-6001, Flammability, Odor, Offgassing, and Compatibility Requirements and Test Procedures for Materials in Environments that Support Combustion.

Growth-rate periodicity of Streptomyces levoris during space flight

NASA Technical Reports Server (NTRS)

Rogers, T. D.; Brower, M. E.; Taylor, G. R.

1977-01-01

Streptomyces levoris provides a suitable biological test system to investigate the effects of space flight on the rhythms of vegetative and spore phase characteristics of both growth-rate periodicity and culture morphology during the pre-, in-, and post-flight periods of the Apollo-Soyuz Test Project. The objectives of the American participation were to study the effects of space flight on the biorhythms of Streptomyces levoris based on a comparison of the growth-rate periodicity of the vegetative and spore phase within each culture, to examine the possible alteration of spore morphology and development by SEM, and to compare the effects of a 12-hr phase shift on the periodic growth characteristics of this microorganism in cultures which were exchanged during the joint activities of the space flight. No uniform differences in the biorhythm of Streptomyces levoris during space flight were observed. It appears that the single most variable factor related to the experiment was the lack of temperature control for the space-flight specimens.

Assessment of Nutritional Intake During Space Flight and Space Flight Analogs

NASA Technical Reports Server (NTRS)

Rice, Barbara L.; Dlouhy, Holly; Zwart, Sara R.; Smith, Scott M.

2011-01-01

Background: Maintaining adequate nutrient intake in microgravity is important not only to meet health maintenance needs of astronauts but also to help counteract the negative effects of space flight. Beyond this, food provides psychosocial benefits throughout a mission. Objective: The purpose of this presentation is to discuss dietary intake data from multiple space programs, including Space Shuttle and the International Space Station. Description: These data arise from medical monitoring of both dietary intake and crew health, as well as research protocols designed to assess the role of diet in counteracting bone loss and other health concerns. Ground-based studies are conducted to better understand some of the negative issues related to space flight. Examples of these analog studies are extended bed rest studies, vitamin D supplementation studies in Antarctica, and saturation diving missions on the floor of the ocean. Methods and findings will be presented describing the use of weighed records, diet diaries, and food frequency questionnaires in these various environments. Provision of food and nutrients in spaceflight is important for many body systems including cardiovascular, musculoskeletal, endocrine, immune, and others. Some key areas of concern are loss of body mass, bone and muscle loss, radiation exposure, nutrient intakes during spacewalks, depletion of nutrient stores, and inadequate dietary intake. Initial experimental research studies using food and nutrition as a countermeasure to aid in mitigating these concerns are underway. Conclusion: Beyond their importance for the few individuals leaving the planet, these studies have significant implications for those remaining on Earth.

Growth-rate periodicity of Streptomyces levoris during space flight.

PubMed

Rogers, T D; Brower, M E; Taylor, G R

1977-01-01

Streptomyces levoris Kras was used is an experimental test micro-organism during the Apollo Soyuz Test Project to study alternating vegetative mycelial and spore ring periodicity during space flight. Four cultures were launched in each of the spacecrafts (Apollo and Soyuz). During the joint space-flight activities, two cultures from each spacecraft were exchanged. Selected duplicate cultures were maintained as controls in both the USA and the USSR. Spore ring morphology was periodically documented by photographing the specimens at approximately 12-hr intervals during the pre-, in-, and post-flight periods of the experiment. A decreased growth-rate periodicity in all but one of the eight space-flight cultures was in part attributed to the reduced temperature in the spacecraft. One of the eight cultures grew at a faster rate in the reduced temperature environment of Apollo than did the ground controls. Three of the space-flight cultures developed double spore rings during the immediate post-flight period. This anomaly was attributed to re-entry into the earth's gravity. The absence of spores in portions of one ring formed during space flight may have been caused by nutritional defects or media abnormality. Extensive studies will be required to elucidate the cause of this detect with certainty. There was no visible evidence of wedges in the cultures which would suggest naturally occurring or radiation-induced mutagenic alteration during space flight.

History of nutrition in space flight: overview

NASA Technical Reports Server (NTRS)

Lane, Helen W.; Feeback, Daniel L.

2002-01-01

Major accomplishments in nutritional sciences for support of human space travel have occurred over the past 40 y. This article reviews these accomplishments, beginning with the early Gemini program and continuing through the impressive results from the first space station Skylab program that focused on life sciences research, the Russian contributions through the Mir space station, the US Shuttle life sciences research, and the emerging International Space Station missions. Nutrition is affected by environmental conditions such as radiation, temperature, and atmospheric pressures, and these are reviewed. Nutrition with respect to space flight is closely interconnected with other life sciences research disciplines including the study of hematology, immunology, as well as neurosensory, cardiovascular, gastrointestinal, circadian rhythms, and musculoskeletal physiology. These relationships are reviewed in reference to the overall history of nutritional science in human space flight. Cumulative nutritional research over the past four decades has resulted in the current nutritional requirements for astronauts. Space-flight nutritional recommendations are presented along with the critical path road map that outlines the research needed for future development of nutritional requirements.

History of nutrition in space flight: overview.

PubMed

Lane, Helen W; Feeback, Daniel L

2002-10-01

Major accomplishments in nutritional sciences for support of human space travel have occurred over the past 40 y. This article reviews these accomplishments, beginning with the early Gemini program and continuing through the impressive results from the first space station Skylab program that focused on life sciences research, the Russian contributions through the Mir space station, the US Shuttle life sciences research, and the emerging International Space Station missions. Nutrition is affected by environmental conditions such as radiation, temperature, and atmospheric pressures, and these are reviewed. Nutrition with respect to space flight is closely interconnected with other life sciences research disciplines including the study of hematology, immunology, as well as neurosensory, cardiovascular, gastrointestinal, circadian rhythms, and musculoskeletal physiology. These relationships are reviewed in reference to the overall history of nutritional science in human space flight. Cumulative nutritional research over the past four decades has resulted in the current nutritional requirements for astronauts. Space-flight nutritional recommendations are presented along with the critical path road map that outlines the research needed for future development of nutritional requirements.

Antimicrobial Medication Stability During Space Flight

NASA Technical Reports Server (NTRS)

Putcha, Lakshmi; Berens, Kurt; Du, Jianping

2004-01-01

The current vision for manned space flight involves lunar and Martian exploration within the next two decades. In order for NASA to achieve these goals, a significant amount of preparation is necessary to assure crew health and safety. A mission critical component of this vision centers around the stability of pharmaceutical preparations contained in the space medicine kits. Evidence suggests that even brief periods of space flight have significant detrimental effects for some pharmaceutical formulations. The effects observed include decreases in physical stability of drug formulations of sufficient magnitude to effect bioavailability. Other formulations exhibit decreases in chemical stability resulting in a loss of potency. Physical or-chemical instability of pharmaceutical formulations i n space medicine kits could render the products ineffective. Of additional concern is the potential for formation of toxic degradation products as a result of the observed product instability. This proposal addresses Question number 11 of Clinical Capabilities in the Critical Path Roadmap. In addition, this proposal will reduce the risks and/or enhance the capabilities of humans exposed to the environments of space flight or an extraterrestrial destination by identifying drugs that may be unstable during spaceflight.

Tropospheric Wind Monitoring During Day-of-Launch Operations for National Aeronautics and Space Administration's Space Shuttle Program

NASA Technical Reports Server (NTRS)

Decker, Ryan K.; Leach, Richard

2004-01-01

The Environments Group at the National Aeronautics and Space Administration's Marshall Space Flight Center (NASA/MSFC) monitors the winds aloft at Kennedy Space Center (KSC) during the countdown for all Space Shuttle launches. Assessment of tropospheric winds is used to support the ascent phase of launch. Three systems at KSC are used to generate independent tropospheric wind profiles prior to launch; 1) high resolution Jimsphere balloon system, 2) 50-MHz Doppler Radar Wind Profiler (DRWP) and 3) low resolution radiosonde system. Data generated by the systems are used to assess spatial and temporal wind variability during launch countdown to ensure wind change observed does not violate wind change criteria constraints.

Inhibited interferon production after space flight

NASA Technical Reports Server (NTRS)

Sonnenfeld, G.; Gould, C. L.; Williams, J.; Mandel, A. D.

1988-01-01

Several studies have been performed in our laboratories indicating that interferon production may be impaired in rodents after space flight. Using an antiorthostatic suspension model that simulates some of the effects of microgravity seen during space flight, we have shown that interferon-alpha/beta production was inhibited. The inhibition was not due solely to the stress of suspension. The inhibited interferon production was transient, as suspended animals returned to normal caging recovered the ability to produce interferon. Antiorthostatic suspension of mice also resulted in a loss of resistance to infection with the diabetogenic strain of encephalomyocarditis virus, which correlated with the drop in interferon production. In rats flown in US Space Shuttle mission SL-3, interferon-gamma production was inhibited severely when spleen cells were challenged with concanavalin-A upon return to earth. In contrast, interleukin-3 production by these cells was normal. These results suggest that immune responses may be altered after antiorthostatic modeling or space flight, and the resistance to viral infections may be especially affected.

Space flight hazards catalog

NASA Technical Reports Server (NTRS)

1975-01-01

The most significant hazards identified on manned space flight programs are listed. This summary is of special value to system safety engineers in developing safety checklists and otherwise tailoring safety tasks to specific systems and subsystems.

Flight Planning Branch Space Shuttle Lessons Learned

NASA Technical Reports Server (NTRS)

Price, Jennifer B.; Scott, Tracy A.; Hyde, Crystal M.

2011-01-01

Planning products and procedures that allow the mission flight control teams and the astronaut crews to plan, train and fly every Space Shuttle mission have been developed by the Flight Planning Branch at the NASA Johnson Space Center. As the Space Shuttle Program ends, lessons learned have been collected from each phase of the successful execution of these Shuttle missions. Specific examples of how roles and responsibilities of console positions that develop the crew and vehicle attitude timelines will be discussed, as well as techniques and methods used to solve complex spacecraft and instrument orientation problems. Additionally, the relationships and procedural hurdles experienced through international collaboration have molded operations. These facets will be explored and related to current and future operations with the International Space Station and future vehicles. Along with these important aspects, the evolution of technology and continual improvement of data transfer tools between the shuttle and ground team has also defined specific lessons used in the improving the control teams effectiveness. Methodologies to communicate and transmit messages, images, and files from Mission Control to the Orbiter evolved over several years. These lessons have been vital in shaping the effectiveness of safe and successful mission planning that have been applied to current mission planning work in addition to being incorporated into future space flight planning. The critical lessons from all aspects of previous plan, train, and fly phases of shuttle flight missions are not only documented in this paper, but are also discussed as how they pertain to changes in process and consideration for future space flight planning.

Acquisition of a Biomedical Database of Acute Responses to Space Flight during Commercial Personal Suborbital Flights

NASA Technical Reports Server (NTRS)

Charles, John B.; Richard, Elizabeth E.

2010-01-01

There is currently too little reproducible data for a scientifically valid understanding of the initial responses of a diverse human population to weightlessness and other space flight factors. Astronauts on orbital space flights to date have been extremely healthy and fit, unlike the general human population. Data collection opportunities during the earliest phases of space flights to date, when the most dynamic responses may occur in response to abrupt transitions in acceleration loads, have been limited by operational restrictions on our ability to encumber the astronauts with even minimal monitoring instrumentation. The era of commercial personal suborbital space flights promises the availability of a large (perhaps hundreds per year), diverse population of potential participants with a vested interest in their own responses to space flight factors, and a number of flight providers interested in documenting and demonstrating the attractiveness and safety of the experience they are offering. Voluntary participation by even a fraction of the flying population in a uniform set of unobtrusive biomedical data collections would provide a database enabling statistical analyses of a variety of acute responses to a standardized space flight environment. This will benefit both the space life sciences discipline and the general state of human knowledge.

Free Industry Flight Training of Inspectors - Federal Aviation Administration

DOT National Transportation Integrated Search

1997-12-09

This is our final report on the audit of Free Industry Flight Training of Federal Aviation Administration (FAA) flight standards" inspectors. We concluded that FAA's Aircrew Designated Examiner Program (Program), which is dependent on a "quid pro quo...

NASA Flight Planning Branch Space Shuttle Lessons Learned

NASA Technical Reports Server (NTRS)

Clevenger, Jennifer D.; Bristol, Douglas J.; Whitney, Gregory R.; Blanton, Mark R.; Reynolds, F. Fisher, III

2011-01-01

Planning products and procedures that allowed the mission Flight Control Teams and the Astronaut crews to plan, train and fly every Space Shuttle mission were developed by the Flight Planning Branch at the NASA Johnson Space Center in Houston, Texas. As the Space Shuttle Program came to a close, lessons learned were collected from each phase of the successful execution of these Space Shuttle missions. Specific examples of how roles and responsibilities of console positions that develop the crew and vehicle attitude timelines have been analyzed and will be discussed. Additionally, the relationships and procedural hurdles experienced through international collaboration have molded operations. These facets will be explored and related to current and future operations with the International Space Station and future vehicles. Along with these important aspects, the evolution of technology and continual improvement of data transfer tools between the Space Shuttle and ground team has also defined specific lessons used in improving the control team s effectiveness. Methodologies to communicate and transmit messages, images, and files from the Mission Control Center to the Orbiter evolved over several years. These lessons were vital in shaping the effectiveness of safe and successful mission planning and have been applied to current mission planning work in addition to being incorporated into future space flight planning. The critical lessons from all aspects of previous plan, train, and fly phases of Space Shuttle flight missions are not only documented in this paper, but are also discussed regarding how they pertain to changes in process and consideration for future space flight planning.

The 2006 Kennedy Space Center Range Reference Atmosphere Model Validation Study and Sensitivity Analysis to the Performance of the National Aeronautics and Space Administration's Space Shuttle Vehicle

NASA Technical Reports Server (NTRS)

Burns, Lee; Decker, Ryan; Harrington, Brian; Merry, Carl

2008-01-01

The Kennedy Space Center (KSC) Range Reference Atmosphere (RRA) is a statistical model that summarizes wind and thermodynamic atmospheric variability from surface to 70 km. The National Aeronautics and Space Administration's (NASA) Space Shuttle program, which launches from KSC, utilizes the KSC RRA data to evaluate environmental constraints on various aspects of the vehicle during ascent. An update to the KSC RRA was recently completed. As part of the update, the Natural Environments Branch at NASA's Marshall Space Flight Center (MSFC) conducted a validation study and a comparison analysis to the existing KSC RRA database version 1983. Assessments to the Space Shuttle vehicle ascent profile characteristics were performed by JSC/Ascent Flight Design Division to determine impacts of the updated model to the vehicle performance. Details on the model updates and the vehicle sensitivity analyses with the update model are presented.

Origin of Marshall Space Flight Center (MSFC)

NASA Image and Video Library

1940-01-01

The German Rocket Team, also known as the Von Braun Rocket Team, poses for a group photograph at Fort Bliss, Texas. After World War II ended in 1945, Dr. Wernher von Braun led some 120 of his Peenemuende Colleagues, who developed the V-2 rocket for the German military during the War, to the United Sttes under a contract to the U.S. Army Corps as part of Operation Paperclip. During the following five years the team worked on high altitude firings of the captured V-2 rockets at the White Sands Missile Range in New Mexico, and a guided missile development unit at Fort Bliss, Texas. In April 1950, the group was transferred to the Army Ballistic Missile Agency (ABMA) at Redstone Arsenal in Huntsville, Alabama, and continued to work on the development of the guided missiles for the U.S. Army until transferring to a newly established field center of the National Aeronautic and Space Administration (NASA), George C. Marshall Space Flight Center (MSFC).

Excretion of amino acids by humans during space flight

NASA Technical Reports Server (NTRS)

Stein, T. P.; Schluter, M. D.

1998-01-01

We measured the urine amino acid distribution patterns before, during and after space flight on the Space Shuttle. The urine samples were collected on two separate flights of the space shuttle. The first flight lasted 9.5 days and the second flight 15 days. Urine was collected continuously on 8 subjects for the period beginning 10 d before launch to 6 d after landing. Results: In contrast to the earlier Skylab missions where a pronounced amino aciduria was found, on shuttle the urinary amino acids showed little change with spaceflight except for a marked decrease in all of the amino acids on FD (flight day) 1 (p<0.05) and a reduction in isoleucine and valine on FD3 and FD4 (p<0.05). Conclusions: (i) Amino aciduria is not an inevitable consequence of space flight. (ii) The occurrence of amino aciduria, like muscle protein breakdown is a mission specific effect rather than part of the general human response to microgravity.

Effects of space flight and IGF-1 on immune function

NASA Astrophysics Data System (ADS)

1999-01-01

We tested the hypothesis that insulin-like growth factor-1 (IGF-1) would ameliorate space flight-induced effects on the immune system. Twelve male, Sprague-Dawley rats, surgically implanted with mini osmotic pumps, were subjected to space flight for 10 days on STS-77. Six rats received 10 mg/kg/day of IGF-1 and 6 rats received saline. Flight animals had a lymphocytopenia and granulocytosis which were reversed by IGF-1. Flight animals had significantly higher corticosterone levels than ground controls but IGF-1 did not impact this stress hormone. Therefore, the reversed granulocytosis did not correlate with serum corticosterone. Space flight and IGF-1 also combined to induce a monocytopenia that was not evident in ground control animals treated with IGF-1 or in animals subjected to space flight but given physiological saline. There was a significant increase in spleen weights in vivarium animals treated with IGF-1, however, this change did not occur in flight animals. We observed reduced agonist-induced lymph node cell proliferation by cells from flight animals compared to ground controls. The reduced proliferation was not augmented by IGF-1 treatment. There was enhanced secretion of TNF, IL-6 and NO by flight-animal peritoneal macrophages compared to vivarium controls, however, O2- secretion was not affected. These data suggest that IGF-1 can ameliorate some of the effects of space flight but that space flight can also impact the normal response to IGF-1.

Overview of Pre-Flight Physical Training, In-Flight Exercise Countermeasures and the Post-Flight Reconditioning Program for International Space Station Astronauts

NASA Technical Reports Server (NTRS)

Kerstman, Eric

2011-01-01

International Space Station (ISS) astronauts receive supervised physical training pre-flight, utilize exercise countermeasures in-flight, and participate in a structured reconditioning program post-flight. Despite recent advances in exercise hardware and prescribed exercise countermeasures, ISS crewmembers are still found to have variable levels of deconditioning post-flight. This presentation provides an overview of the astronaut medical certification requirements, pre-flight physical training, in-flight exercise countermeasures, and the post-flight reconditioning program. Astronauts must meet medical certification requirements on selection, annually, and prior to ISS missions. In addition, extensive physical fitness testing and standardized medical assessments are performed on long duration crewmembers pre-flight. Limited physical fitness assessments and medical examinations are performed in-flight to develop exercise countermeasure prescriptions, ensure that the crewmembers are physically capable of performing mission tasks, and monitor astronaut health. Upon mission completion, long duration astronauts must re-adapt to the 1 G environment, and be certified as fit to return to space flight training and active duty. A structured, supervised postflight reconditioning program has been developed to prevent injuries, facilitate re-adaptation to the 1 G environment, and subsequently return astronauts to training and space flight. The NASA reconditioning program is implemented by the Astronaut Strength, Conditioning, and Rehabilitation (ASCR) team and supervised by NASA flight surgeons. This program has evolved over the past 10 years of the International Space Station (ISS) program and has been successful in ensuring that long duration astronauts safely re-adapt to the 1 g environment and return to active duty. Lessons learned from this approach to managing deconditioning can be applied to terrestrial medicine and future exploration space flight missions.

Brian Dunlap Tours Marshall Space Flight Center (MSFC)

NASA Technical Reports Server (NTRS)

1972-01-01

W. Brain Dunlap (left), high school student from Youngstown, Ohio, is pictured here with Harry Coons of the Marshall Space Flight Center (MSFC) during a visit to the center. Dunlap was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year's Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Gregory Merkel Tours Marshall Space Flight Center (MSFC)

NASA Technical Reports Server (NTRS)

1972-01-01

Gregory A. Merkel (left), high school student from Springfield, Massachusetts, is pictured here with Harry Coons of the Marshall Space Flight Center (MSFC) during a visit to the center. Merkel was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year's Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

Renal stone risk assessment during Space Shuttle flights

NASA Technical Reports Server (NTRS)

Whitson, P. A.; Pietrzyk, R. A.; Pak, C. Y.

1997-01-01

PURPOSE: The metabolic and environmental factors influencing renal stone formation before, during, and after Space Shuttle flights were assessed. We established the contributing roles of dietary factors in relationship to the urinary risk factors associated with renal stone formation. MATERIALS AND METHODS: 24-hr. urine samples were collected prior to, during space flight, and following landing. Urinary and dietary factors associated with renal stone formation were analyzed and the relative urinary supersaturation of calcium oxalate, calcium phosphate (brushite), sodium urate, struvite and uric acid were calculated. RESULTS: Urinary composition changed during flight to favor the crystallization of calcium-forming salts. Factors that contributed to increased potential for stone formation during space flight were significant reductions in urinary pH and increases in urinary calcium. Urinary output and citrate, a potent inhibitor of calcium-containing stones, were slightly reduced during space flight. Dietary intakes were significantly reduced for a number of variables, including fluid, energy, protein, potassium, phosphorus and magnesium. CONCLUSIONS: This is the first in-flight characterization of the renal stone forming potential in astronauts. With the examination of urinary components and nutritional factors, it was possible to determine the factors that contributed to increased risk or protected from risk. In spite of the protective components, the negative contributions to renal stone risk predominated and resulted in a urinary environment that favored the supersaturation of stone-forming salts. Dietary and pharmacologic therapies need to be assessed to minimize the potential for renal stone formation in astronauts during/after space flight.

14 CFR Appendix E to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant E Appendix E to Part 440 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING...

14 CFR Appendix E to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant E Appendix E to Part 440 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING...

14 CFR Appendix E to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant E Appendix E to Part 440 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING...

14 CFR Appendix E to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant E Appendix E to Part 440 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING...

14 CFR Appendix E to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant E Appendix E to Part 440 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING...

Sub-orbital flights, a starting point for space tourism

NASA Astrophysics Data System (ADS)

Gaubatz, William A.

2002-07-01

While there is a growing awareness and interest by the general public in space travel neither the market nor the infrastructure exist to make a commercial space tourism business an attractive risk venture. In addition there is much to be learned about how the general public will respond to space flights and what physiological and psychological needs must be met to ensure a pleasurable as well as adventurous experience. Sub-orbital flights offer an incremental approach to develop the market and the infrastructure, demonstrate the safety of space flight, obtain real flight information regarding the needs of general public passengers and demonstrate the profitability of space tourism. This paper will summarize some of the system, operations, and financial aspects of creating a sub-orbital space tourism business as a stepping-stone to public space travel. A sample business case will be reviewed and impacts of markets, operations and vehicle costs and lifetimes will be assessed.

Long-Duration Space Flight Provokes Pathologic Q-Tc Interval Prolongation

NASA Technical Reports Server (NTRS)

D'Aunno, DOminick S.; Dougherty, Anne H.; DeBlock, Heidi F.; Meck, Janice V.

2002-01-01

Space flight has a profound influence on the cardiovascular and autonomic nervous systems. Alterations in baroreflex function, plasma catecholamine concentrations, and arterial pressure regulation have been observed. Changes in autonomic regulation of cardiac function may lead to serious rhythm disturbances. In fact, ventricular tachycardia has been reported during long-duration space flight. The study aim was to determine the effects of space flight on cardiac conduction. Methods and Results: Electrocardiograms (ECGs) and serum electrolytes were obtained before and after short-duration (SD) (4-16 days) and long-duration (LD) (4-6 months) missions. Holter recordings were obtained from 3 different subjects before, during and after a 4-month mission. P-R, R-R, and Q-T intervals were measured manually in a random, blinded fashion and Bazzet's formula used to correct the Q-T interval (Q-Tc). Space flight had no clinically significant effect on electrolyte concentrations. P-R and RR intervals were decreased after SD flight (p<0.05) and recovered 3 days after landing. In the same subjects, P-R and Q-Tc intervals were prolonged after LD flight (p<0.01). Clinically significant Q-Tc prolongation (>0.44 sec) occurred during the first month of flight and persisted until 3 days after landing (p<0.01). Conclusions - Space flight alters cardiac conduction with more ominous changes seen with LD missions. Alterations in autonomic tone may explain ECG changes associated with space flight. Primary cardiac changes may also contribute to the conduction changes with LD flight. Q-Tc prolongation may predispose astronauts to ventricular arrhythmias during and after long-duration space flight.

Nutrition in Space Flight: Some Thoughts

NASA Technical Reports Server (NTRS)

Johnson, P. C., Jr.

1985-01-01

Space flight causes physiological changes related to microgravity and on which nutrition has a bearing. Examples are: muscle atrophy-protein; bone atrophy-calcium; phosphorus, and vitamin D; space sickness-fat; cardiovascular deconditioning-sodium; water, and potassium. The physiological changes are discussed which relate to living in space.

Movable Ground Based Recovery System for Reuseable Space Flight Hardware

NASA Technical Reports Server (NTRS)

Sarver, George L. (Inventor)

2013-01-01

A reusable space flight launch system is configured to eliminate complex descent and landing systems from the space flight hardware and move them to maneuverable ground based systems. Precision landing of the reusable space flight hardware is enabled using a simple, light weight aerodynamic device on board the flight hardware such as a parachute, and one or more translating ground based vehicles such as a hovercraft that include active speed, orientation and directional control. The ground based vehicle maneuvers itself into position beneath the descending flight hardware, matching its speed and direction and captures the flight hardware. The ground based vehicle will contain propulsion, command and GN&C functionality as well as space flight hardware landing cushioning and retaining hardware. The ground based vehicle propulsion system enables longitudinal and transverse maneuverability independent of its physical heading.

Finding of No Significant Impact and Environmental Assessment for Flight Test to the Edge of Space

DTIC Science & Technology

2008-12-01

Regulations [CFR] 1500–1508); 32 CFR Part 989, Environmental Impact Analysis Process; and National Aeronautics and Space Administration ( NASA ) policy and...agency. NASA Dryden Flight Research Center is a cooperating agency in the preparation of this EA. This programmatic EA serves as the foundation for... NASA installation or from any spaceport, or they could be air-launched from a carrier aircraft. Under Alternative B, high-speed vehicle flights would

Flight Opportunities: Space Technology Mission Directorate

NASA Technical Reports Server (NTRS)

Van Dijk, Alexander

2016-01-01

Flight Opportunities enables maturation of new space technologies by funding access to commercially available space-relevant test environments. The program also supports capability development in the commercial suborbital and orbital small satellite launcher markets.

Evaluation of in vitro macrophage differentiation during space flight

NASA Astrophysics Data System (ADS)

Ortega, M. Teresa; Lu, Nanyan; Chapes, Stephen K.

2012-05-01

We differentiated mouse bone marrow cells in the presence of recombinant macrophage colony stimulating (rM-CSF) factor for 14 days during the flight of space shuttle Space Transportation System (STS)-126. We tested the hypothesis that the receptor expression for M-CSF, c-Fms was reduced. We used flow cytometry to assess molecules on cells that were preserved during flight to define the differentiation state of the developing bone marrow macrophages; including CD11b, CD31, CD44, Ly6C, Ly6G, F4/80, Mac2, c-Fos as well as c-Fms. In addition, RNA was preserved during the flight and was used to perform a gene microarray. We found that there were significant differences in the number of macrophages that developed in space compared to controls maintained on Earth. We found that there were significant changes in the distribution of cells that expressed CD11b, CD31, F4/80, Mac2, Ly6C and c-Fos. However, there were no changes in c-Fms expression and no consistent pattern of advanced or retarded differentiation during space flight. We also found a pattern of transcript levels that would be consistent with a relatively normal differentiation outcome but increased proliferation by the bone marrow macrophages that were assayed after 14 days of space flight. There also was a surprising pattern of space flight influence on genes of the coagulation pathway. These data confirm that a space flight can have an impact on the in vitro development of macrophages from mouse bone marrow cells.

Evaluation of in vitro macrophage differentiation during space flight.

PubMed

Ortega, M Teresa; Lu, Nanyan; Chapes, Stephen K

2012-05-15

We differentiated mouse bone marrow cells in the presence of recombinant macrophage colony stimulating (rM-CSF) factor for 14 days during the flight of space shuttle Space Transportation System (STS)-126. We tested the hypothesis that the receptor expression for M-CSF, c-Fms was reduced. We used flow cytometry to assess molecules on cells that were preserved during flight to define the differentiation state of the developing bone marrow macrophages; including CD11b, CD31, CD44, Ly6C, Ly6G, F4/80, Mac2, c-Fos as well as c-Fms. In addition, RNA was preserved during the flight and was used to perform a gene microarray. We found that there were significant differences in the number of macrophages that developed in space compared to controls maintained on Earth. We found that there were significant changes in the distribution of cells that expressed CD11b, CD31, F4/80, Mac2, Ly6C and c-Fos. However, there were no changes in c-Fms expression and no consistent pattern of advanced or retarded differentiation during space flight. We also found a pattern of transcript levels that would be consistent with a relatively normal differentiation outcome but increased proliferation by the bone marrow macrophages that were assayed after 14 days of space flight. There also was a surprising pattern of space flight influence on genes of the coagulation pathway. These data confirm that a space flight can have an impact on the in vitro development of macrophages from mouse bone marrow cells.

Marshall Space Flight Center CFD overview

NASA Technical Reports Server (NTRS)

Schutzenhofer, Luke A.

1989-01-01

Computational Fluid Dynamics (CFD) activities at Marshall Space Flight Center (MSFC) have been focused on hardware specific and research applications with strong emphasis upon benchmark validation. The purpose here is to provide insight into the MSFC CFD related goals, objectives, current hardware related CFD activities, propulsion CFD research efforts and validation program, future near-term CFD hardware related programs, and CFD expectations. The current hardware programs where CFD has been successfully applied are the Space Shuttle Main Engines (SSME), Alternate Turbopump Development (ATD), and Aeroassist Flight Experiment (AFE). For the future near-term CFD hardware related activities, plans are being developed that address the implementation of CFD into the early design stages of the Space Transportation Main Engine (STME), Space Transportation Booster Engine (STBE), and the Environmental Control and Life Support System (ECLSS) for the Space Station. Finally, CFD expectations in the design environment will be delineated.

Space Flight Ionizing Radiation Environments

NASA Technical Reports Server (NTRS)

Koontz, Steve

2017-01-01

The space-flight ionizing radiation (IR) environment is dominated by very high-kinetic energy-charged particles with relatively smaller contributions from X-rays and gamma rays. The Earth's surface IR environment is not dominated by the natural radioisotope decay processes. Dr. Steven Koontz's lecture will provide a solid foundation in the basic engineering physics of space radiation environments, beginning with the space radiation environment on the International Space Station and moving outward through the Van Allen belts to cislunar space. The benefits and limitations of radiation shielding materials will also be summarized.

Human Space Flight Plans Committee

NASA Image and Video Library

2009-06-16

Norman Augustine, chair of the Human Space Flight Review Committee, front center, is joined by other members of the committee, clockwise from left, Bohdan Bejmuk, Leroy Chiao, Dr. Wanda Austin, Philip McAlister, Dr. Edward Crawley, Jeffrey Greason and Dr. Christopher Chyba prior to the start of the first of several public meetings at different U.S. locations, Wednesday, June 17, 2009, at the Carnegie Institution in Washington. The panel will examine ongoing and planned NASA development activities and potential alternatives in order to present options for advancing a safe, innovative, affordable and sustainable human space flight program following the space shuttle's retirement. The committee wil present its results by August 2009. Members of the committee that were not in attendance and are not pictured are Dr. Charles Kennel, Retired Air Force Gen. Lester Lyles and former astronaut Sally Ride. Photo Credit: (NASA/Paul E. Alers)

Nutrition, endocrinology, and body composition during space flight

NASA Technical Reports Server (NTRS)

Lane, H. W.; Gretebeck, R. J.; Smith, S. M.

1998-01-01

Space flight induces endocrine changes that perturb metabolism. This altered metabolism affects both the astronauts' body composition and the nutritional requirements necessary to maintain their health. During the last 25 years, a combination of studies conducted on Skylab (the first U.S. space laboratory), U.S. Shuttle flights, and Soviet and Russian flights provides a range of data from which general conclusions about energy and protein requirements can be drawn. We have reviewed the endocrine data from those studies and related it to changes in body composition. From these data it appears that protein and energy intake of astronauts are similar to those on Earth. However, a combination of measures, including exercise, appropriate diet, and, potentially, drugs, is required to provide the muscle health needed for long duration space flight.

Calcium Kinetics During Space Flight

NASA Technical Reports Server (NTRS)

Smith, Scott M.; Wastney, Meryl E.; OBrien, Kimberly O.; Lane, Helen W.

1999-01-01

Bone loss is one of the most detrimental effects of space flight, threatening to limit the duration of human space missions. The ability to understand and counteract this loss will be critical for crew health and safety during and after extended-duration missions. The hypotheses to be tested in this project are that space flight alters calcium homeostasis and bone mineral metabolism, and that calcium homeostasis and bone mineral metabolism will return to baseline within days to weeks of return to Earth. These hypotheses will be evidenced by elevated rates of bone mineral resorption and decreased bone mineral deposition, decreased absorption of dietary calcium, altered calcitropic endocrine profiles, elevated excretion of calcium in urine and feces, and elevated excretion of markers of bone resorption. The second hypothesis will be evidenced by return of indices of calcium homeostasis and bone metabolism to preflight levels within days to weeks of return to Earth. Studies will be conducted on International Space Station astronauts before, during, and after extended-duration flights. Measurements of calcium kinetics, bone mass, and endocrine/biochemical markers of bone and calcium homeostasis will be conducted. Kinetic studies utilizing dual isotope tracer kinetic studies and mathematical modeling techniques will allow for determination of bone calcium deposition, bone calcium resorption, dietary calcium absorption and calcium excretion (both urinary and endogenous fecal excretion). These studies will build upon preliminary work conducted on the Russian Mir space station. The results from this project will be critical for clarifying how microgravity affects bone and calcium homeostasis, and will provide an important control point for assessment of countermeasure efficacy. These results are expected to aid in developing countermeasures for bone loss, both for space crews and for individuals on Earth who have metabolic bone diseases.

Space flight nutrition research: platforms and analogs

NASA Technical Reports Server (NTRS)

Smith, Scott M.; Uchakin, Peter N.; Tobin, Brian W.

2002-01-01

Conducting research during actual or simulated weightlessness is a challenging endeavor, where even the simplest activities may present significant challenges. This article reviews some of the potential obstacles associated with performing research during space flight and offers brief descriptions of current and previous space research platforms and ground-based analogs, including those for human, animal, and cell-based research. This review is intended to highlight the main issues of space flight research analogs and leave the specifics for each physiologic system for the other papers in this section.

[Effect of space flight on yield of Monascus purpureus].

PubMed

Yin, Hong; Xie, Shen-yi; Zhang, Guang-ming; Xie, Shen-meng

2003-10-01

To select high Lovastatin-producing microbial breed by space flight. Monascus purpureus species was carried into space by the recoverable spaceship, "Shenzhou 3". After flight, the strain was rejuvenized, segregated and selected. The content of Lovastatin produced in the solid fermentation was examined. Mutants with high productivity of Lovastatin were obtained. A series of tests showed that the acquired character of the mutants was stable. Space flight is an effective method for the selection of fine strains.

Cognitive Assessment During Long-Duration Space Flight

NASA Technical Reports Server (NTRS)

Seaton, Kimberly; Kane, R. L.; Sipes, Walter

2010-01-01

The Space Flight Cognitive Assessment Tool for Windows (WinSCAT) is a computer-based, self-administered battery of five cognitive assessment tests developed for medical operations at NASA's Johnson Space Center in Houston, Texas. WinSCAT is a medical requirement for U.S. long-duration astronauts and has been implemented with U.S. astronauts from one NASA/Mir mission (NASA-7 mission) and all expeditions to date on the International Space Station (ISS). Its purpose is to provide ISS crew surgeons with an objective clinical tool after an unexpected traumatic event, a medical condition, or the cumulative effects of space flight that could negatively affect an astronaut's cognitive status and threaten mission success. WinSCAT was recently updated to add network capability to support a 6-person crew on the station support computers. Additionally, WinSCAT Version 2.0.28 has increased difficulty of items in Mathematics, increased number of items in Match-to-Sample, incorporates a moving rather than a fixed baseline, and implements stricter interpretation rules. ISS performance data were assessed to compare initial to modified interpretation rules for detecting potential changes in cognitive functioning during space flight. WinSCAT tests are routinely taken monthly during an ISS mission. Performance data from these ISS missions do not indicate significant cognitive decrements due to microgravity/space flight alone but have shown decrements. Applying the newly derived rules to ISS data results in a number of off-nominal performances at various times during and after flight.. Correlation to actual events is needed, but possible explanations for off-nominal performances could include actual physical factors such as toxic exposure, medication effects, or fatigue; emotional factors including stress from the mission or life events; or failure to exert adequate effort on the tests.

Intersatellite communications optoelectronics research at the Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Krainak, Michael A.

1992-01-01

A review is presented of current optoelectronics research and development at the NASA Goddard Space Flight Center for high-power, high-bandwidth laser transmitters; high-bandwidth, high-sensitivity optical receivers; pointing, acquisition, and tracking components; and experimental and theoretical system modeling at the NASA Goddard Space Flight Center. Program hardware and space flight opportunities are presented.

Long range planning for the development of space flight emergency systems.

NASA Technical Reports Server (NTRS)

Bolger, P. H.; Childs, C. W.

1972-01-01

The importance of long-range planning for space flight emergency systems is pointed out. Factors in emergency systems planning are considered, giving attention to some of the mission classes which have to be taken into account. Examples of the hazards in space flight include fire, decompression, mechanical structure failures, radiation, collision, and meteoroid penetration. The criteria for rescue vehicles are examined together with aspects regarding the conduction of rescue missions. Future space flight programs are discussed, taking into consideration low earth orbit space stations, geosynchronous orbit space stations, lunar operations, manned planetary missions, future space flight vehicles, the space shuttle, special purpose space vehicles, and a reusable nuclear shuttle.

The effects of space radiation on flight film

NASA Technical Reports Server (NTRS)

Holly, Mark H.

1995-01-01

The Shuttle and its cargo are occasionally exposed to an amount of radiation large enough to create non-image forming exposures (fog) on photographic flight film. The television/photography working group proposed a test plan to quantify the sensitivity of photographic films to space radiation. This plan was flown on STS-37 and was later incorporated into a detailed supplementary objective (DSO) which was flown on STS48. This DSO addressed the effects of significant space radiation on representative samples of six highly sensitive flight films. In addition, a lead-lined bag was evaluated as a potential shield for flight film against space radiation.

Marshall Space Flight Center's Education Department

NASA Technical Reports Server (NTRS)

Henderson, Arthur J., Jr.; Whitaker, Ann F. (Technical Monitor)

2000-01-01

Marshall Space Flight Center's Education Department is a resource for Educator, Students and Lifelong Learners. This paper will highlight the Marshall Space Flight Center's Education Department with references to other NASA Education Departments nationwide. The principal focus will be on the responsibilities of the Pre-college Education Team which is responsible for supporting K- 12 teachers highlighting how many of the NASA Pre-college Offices engage teachers and their students in better understanding NASA's inspiring missions, unique facilities, and specialized workforce to carryout these many agency-wide tasks, goals and objectives. Attendee's will learn about the Marshall Educational Alliance Teams, as well, which is responsible for using NASA's unique assets to support all types of learning. All experience and knowledge levels, all grades K-12, and teachers in these specified groupings will gain a true appreciation of what is available for them, through Marshall Space Flight Center's Education Department. An agency-wide blue directory booklet will be distributed to all attendees, for future references and related points of contact.

Space Flight Software Development Software for Intelligent System Health Management

NASA Technical Reports Server (NTRS)

Trevino, Luis C.; Crumbley, Tim

2004-01-01

The slide presentation examines the Marshall Space Flight Center Flight Software Branch, including software development projects, mission critical space flight software development, software technical insight, advanced software development technologies, and continuous improvement in the software development processes and methods.

48 CFR 1852.246-73 - Human space flight item.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Human space flight item. 1852.246-73 Section 1852.246-73 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... 1852.246-73 Human space flight item. As prescribed in 1845.370(b), insert the following clause: Human...

48 CFR 1852.246-73 - Human space flight item.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Human space flight item. 1852.246-73 Section 1852.246-73 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... 1852.246-73 Human space flight item. As prescribed in 1845.370(b), insert the following clause: Human...

48 CFR 1852.246-73 - Human space flight item.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Human space flight item. 1852.246-73 Section 1852.246-73 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... 1852.246-73 Human space flight item. As prescribed in 1845.370(b), insert the following clause: Human...

48 CFR 1852.246-73 - Human space flight item.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Human space flight item. 1852.246-73 Section 1852.246-73 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... 1852.246-73 Human space flight item. As prescribed in 1845.370(b), insert the following clause: Human...

48 CFR 1852.246-73 - Human space flight item.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Human space flight item. 1852.246-73 Section 1852.246-73 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... 1852.246-73 Human space flight item. As prescribed in 1845.370(b), insert the following clause: Human...

Space flight and the immune system

NASA Technical Reports Server (NTRS)

Cogoli, A.

1993-01-01

Depression of lymphocyte response to mitogens in cosmonauts after space flight was reported for the first time in the early 1970s by Soviet immunologists. Today we know that depression of lymphocyte function affects at least 50% of space crew members. Investigations on the ground on subjects undergoing physical and psychological stress indicate that stress is a major factor in immune depression of astronauts. This is despite the fact that weightlessness per se has a strong inhibitory effect on lymphocyte activation in vitro. Although the changes observed never harmed the health of astronauts, immunological changes must be seriously investigated and understood in view of long-duration flight on space stations in an Earth orbit, to other planets such as Mars and to the Moon.

STS-132 Flight Control Team in WFCR

NASA Image and Video Library

2010-05-25

JSC2010-E-087358 (25 May 2010) --- The members of the STS-132 Entry flight control team pose for a group portrait in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Tony Ceccacci holds the STS-132 mission logo. Photo credit: NASA or National Aeronautics and Space Administration

Regulation of erythropoiesis in rats during space flight

NASA Technical Reports Server (NTRS)

Lange, Robert D.

1989-01-01

Astronauts who have flown in microgravity have experienced a loss in red cell mass. The pathogenesis of the anemia of space flight has not been ascertained, but it is probably multifactorial. In 1978, the laboratory was selected to participate in life sciences studies to be carried out in the space shuttle in an attempt to study the pathogenesis of space anemia. In particular, the original studies were to be made in mice. This was later changed to study erythropoiesis in rats during space flight.

Human Space Flight Plans Committee

NASA Image and Video Library

2009-08-11

Norman Augustine, chair, listens to a speaker's presentation during the final meeting of the Human Space Flight Review Committee, Wednesday, Aug. 12, 2009, in Washington. Photo Credit: (NASA/Paul E. Alers)

Space Shuttle Environmental Effects: The First 5 Flights

NASA Technical Reports Server (NTRS)

Potter, A. (Editor)

1983-01-01

Environmental effects associated with the first five Space Shuttle flights were monitored by the National Aeronautics and Space Administration (NASA) and the U.S. Air Force (USAF). Results and interpretations from this effort were reported at the December 1982 joint NASA-USAF conference. The conference proceedings are presented in this document. Most of the monitoring activity was focused on the launch cloud, emphasizing surface effects on the biota and air quality, model prediction of surface concentrations of HCl gas and Al2O3 dust, and airborne measurements of cloud composition. In general, assessments and predictions made in the April 1978 Final Environmental Impact Statement for the Space Shuttle Program were verified. Fallout of acidic mist and dust within 3 mi to 5 mi of the launch pad was the only unexpected effect of the launch. Atomization of deluge water in the Shuttle exhaust is considered to be the most probable cause of this effect. Sonic booms were monitored for several landings at Edwards Air Force Base, California; results agreed well with model predictions.

Lytic Replication of Epstein-Barr Virus During Space Flight

NASA Technical Reports Server (NTRS)

Stowe, R. P.; Pierson, D. L.; Barrett, A. D. T.

1999-01-01

Reactivation of latent Epstein-Barr virus (EBV) may be an important threat to crew health during extended space missions. Cellular immunity, which is decreased during and after space flight, is responsible for controlling EBV replication in vivo. In this study, we investigated the effects of short-term space flight on latent EBV reactivation.

Water and Energy Dietary Requirements and Endocrinology of Human Space Flight

NASA Technical Reports Server (NTRS)

Lane, Helen W.; Feeback, Daniel L.

2002-01-01

Fluid and energy metabolism and related endocrine changes have been studied nearly from the beginning of human space flight in association with short- and long-duration flights. Fluid and electrolyte nutrition status is affected by many factors including the microgravity environment, stress, changes in body composition, diet, exercise habits, sleep cycles, and ambient temperature and humidity conditions. Space flight exposes astronauts to all these factors and consequently poses significant challenges to establishing dietary water, sodium, potassium, and energy recommendations. The purpose of this article is to review the results of ground-based and space flight research studies that have led to current water, electrolyte, and energy dietary requirements for humans during space flight and to give an overview of related endocrinologic changes that have been observed in humans during short- and long-duration space flight.

Apollo experience report: Development flight instrumentation. [telemetry equipment for space flight test program

NASA Technical Reports Server (NTRS)

Farmer, N. B.

1974-01-01

Development flight instrumentation was delivered for 25 Apollo vehicles as Government-furnished equipment. The problems and philosophies of an activity that was concerned with supplying telemetry equipment to a space-flight test program are discussed. Equipment delivery dates, system-design details, and flight-performance information for each mission also are included.

Space robotic experiment in JEM flight demonstration

NASA Technical Reports Server (NTRS)

Nagatomo, Masanori; Tanaka, Masaki; Nakamura, Kazuyuki; Tsuda, Shinichi

1994-01-01

Japan is collaborating on the multinational space station program. The JEM, Japanese Experiment Module, has both a pressurized module and an Exposed Facility (EF). JEM Remote Manipulator System (JEMRMS) will play a dominant role in handling/servicing payloads and the maintenance of the EF, and consists of two robotic arms, a main arm and a small fine arm. JEM Flight Demonstration (JFD) is a space robotics experiment using the prototype small fine arm to demonstrate its capability, prior to the Space Station operation. The small fine arm will be installed in the Space Shuttle cargo bay and operated by a crew from a dedicated workstation in the Aft Flight Deck of the orbiter.

Origin of Marshall Space Flight Center (MSFC)

NASA Image and Video Library

1960-09-08

President Dwight D. Eisenhower and Mrs. George C. Marshall unveil the bronze bust of General George C. Marshall during the dedication of the Marshall Space Flight Center. Eisenhower signed an Executive Order on October 21, 1959 directing the transfer of persornel from the Redstone Arsenal's Army Ballistic Missile Agency Development Operations Division to NASA. On March 15, 1960, another Executive Order announced that the space complex formed within the boundaries of Redstone Arsenal would become the George C. Marshall Space Flight Center. The Center was activated on July 1, 1960, with dedication ceremonies taking place September 8, 1960.

14 CFR 129.15 - Flight crewmember certificates.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight crewmember certificates. 129.15 Section 129.15 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... § 129.15 Flight crewmember certificates. No person may act as a flight crewmember unless he holds a...

14 CFR 29.673 - Primary flight controls.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Primary flight controls. 29.673 Section 29.673 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... flight controls. Primary flight controls are those used by the pilot for immediate control of pitch, roll...

14 CFR 29.673 - Primary flight controls.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Primary flight controls. 29.673 Section 29.673 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... flight controls. Primary flight controls are those used by the pilot for immediate control of pitch, roll...

14 CFR 27.673 - Primary flight control.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Primary flight control. 27.673 Section 27.673 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... flight control. Primary flight controls are those used by the pilot for immediate control of pitch, roll...

14 CFR 27.673 - Primary flight control.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Primary flight control. 27.673 Section 27.673 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... flight control. Primary flight controls are those used by the pilot for immediate control of pitch, roll...

Maximum Oxygen Uptake During and After Long-Duration Space Flight

NASA Technical Reports Server (NTRS)

Moore, Alan D., Jr.; Evetts, Simon N.; Feiveson, Alan H.; Lee, Stuart M. C.; McCleary. Frank A.; Platts, Steven H.

2010-01-01

Decreased maximum oxygen consumption (VO2max) during and after space flight may impair a crewmember s ability to perform mission-critical work that is high intensity and/or long duration in nature (Human Research Program Integrated Research Plan Risk 2.1.2: Risk of Reduced Physical Performance Capabilities Due to Reduced Aerobic Capacity). When VO2max was measured in Space Shuttle experiments, investigators reported that it did not change during short-duration space flight but decreased immediately after flight. Similar conclusions, based on the heart rate (HR) response of Skylab crewmembers, were made previously concerning long-duration space flight. Specifically, no change in the in-flight exercise HR response in 8 of 9 Skylab crewmembers indicated that VO2max was maintained during flight, but the elevated exercise HR after flight indicated that VO2max was decreased after landing. More recently, a different pattern of in-flight exercise HR response, and assumed changes in VO2max, emerged from routine testing of International Space Station (ISS) crewmembers. Most ISS crewmembers experience an elevated in-flight exercise HR response early in their mission, with a gradual return toward preflight levels as the mission progresses. Similar to previous reports, exercise HR is elevated after ISS missions and returns to preflight levels by 30 days after landing. VO2max has not been measured either during or after long-duration space flight. The purposes of the ISS VO2max experiment are (1) to measure VO2max during and after long-duration spaceflight, and (2) to determine if submaximal exercise test results can be used to accurately estimate VO 2max.

Human Space Flight Plans Committee

NASA Image and Video Library

2009-08-11

Bohdan Bejmuk, chair, Constellation program Standing Review Board, and former manager of the Boeing Space Shuttle and Sea Launch programs, right, asks a question during the final meeting of the Human Space Flight Review Committee as Dr. Wanda Austin, president and CEO, The Aerospace Corp., looks on at left, Wednesday, Aug. 12, 2009, in Washington. Photo Credit: (NASA/Paul E. Alers)

Clean Room at Goddard Space Flight Center

NASA Image and Video Library

2010-03-10

This panorama shows the inside of Goddard's High Bay Clean Room, as seen from the observation deck. Credit: NASA/Goddard Space Flight Center/Chris Gunn Go into a NASA Clean Room Daily with the Webb Telescope via NASA's 'Webb-cam' here: www.jwst.nasa.gov/webcam.html For more information on JWST go to: www.jwst.nasa.gov/ For more information on Goddard Space Flight Center go to: www.nasa.gov/centers/goddard/home/index.html

Critical Technology Determination for Future Human Space Flight

NASA Technical Reports Server (NTRS)

Mercer, Carolyn R.; Vangen, Scott D.; Williams-Byrd, Julie A.; Steckleim, Jonette M.; Alexander, Leslie; Rahman, Shamin A.; Rosenthal, Matthew; Wiley, Dianne S.; Davison, Stephan C.; Korsmeyer, David J.;

Critical Technology Determination for Future Human Space Flight

NASA Technical Reports Server (NTRS)

Mercer, Carolyn R.; Vangen, Scott D.; Williams-Byrd, Julie A.; Stecklein, Jonette M.; Rahman, Shamim A.; Rosenthal, Matthew E.; Hornyak, David M.; Alexander, Leslie; Korsmeyer, David J.; Tu, Eugene L.;

Biochemical and hematologic changes after short-term space flight

NASA Technical Reports Server (NTRS)

Leach, Carolyn S.

1991-01-01

Clinical laboratory data from blood samples obtained from astronauts before and after 28 flights (average duration = 6 days) of the Space Shuttle were analyzed by the paired t-test and the Wilcoxon signed-rank test and compared with data from the Skylab flights (duration = 28, 56, and 84 days). Angiotensin I and aldosterone were elevated immediately after short-term space flights, but the response of angiotensin I was delayed after Skylab flights. Serum calcium was not elevated after Shuttle flights, but magnesium and uric acid decreased after both Shuttle and Skylab. Creatine phosphokinase in serum was reduced after Shuttle but not Skylab flights, probably because exercises to prevent deconditioning were not performed on the Shuttle. Total cholesterol was unchanged after Shuttle flights, but low density lipoprotein cholesterol increased and high density lipoprotein cholesterol decreased. The concentration of red blood cells was elevated after Shuttle flights and reduced after Skylab flights.

Physical examination during space flight

NASA Technical Reports Server (NTRS)

Harris, B. A. Jr; Billica, R. D.; Bishop, S. L.; Blackwell, T.; Layne, C. S.; Harm, D. L.; Sandoz, G. R.; Rosenow, E. C. 3rd

1997-01-01

OBJECTIVE: To develop techniques for conducting a physical examination in microgravity and to describe and document the physiologic changes noted with use of a modified basic physical examination. DESIGN: On the basis of data gathered from physical examinations on KC-135 flights, three physical variables were assessed serially in astronauts during two shuttle missions (of 8- and 10-day duration, respectively). Preflight, in-flight, and postflight examinations were conducted by trained physician-astronauts or flight surgeons, who used this modified examination. MATERIAL AND METHODS: Five male and two female crewmembers participated in the "hands-on" physical examination of all physiologic systems except the genitourinary system. Level of edema, intensity of bowel sounds, and peripheral reflexes were assessed and graded. RESULTS: This investigation identified unique elements of a physical examination performed during space flight that will assist in the development of standard methods for conducting examinations of astronauts in weightlessness. In addition, demonstrable changes induced by microgravity were noted in most physiologic systems examined. CONCLUSION: The data support the hypothesis that the microgravity examination differs from that conducted on earth or in a 1g environment. In addition, alterations in the physiologic response can be detected with use of hands-on technique. These data are invaluable in the development of optimal medical care for humans in space.

14 CFR 25.1523 - Minimum flight crew.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Minimum flight crew. 25.1523 Section 25.1523 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... Limitations § 25.1523 Minimum flight crew. The minimum flight crew must be established so that it is...

14 CFR 29.1523 - Minimum flight crew.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Minimum flight crew. 29.1523 Section 29.1523 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... Limitations § 29.1523 Minimum flight crew. The minimum flight crew must be established so that it is...

14 CFR 27.1523 - Minimum flight crew.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Minimum flight crew. 27.1523 Section 27.1523 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... § 27.1523 Minimum flight crew. The minimum flight crew must be established so that it is sufficient for...

Kids in Space Water Absorption Flight Procedures #40 Demo

NASA Image and Video Library

2010-09-15

ISS024-E-014988 (15 Sept. 2010) --- NASA astronaut Tracy Caldwell Dyson, Expedition 24 flight engineer, conducts a demonstration for the "Kids in Space" session for Water Absorption Flight Procedures #40 in the Columbus laboratory of the International Space Station.

Kids in Space Water Absorption Flight Procedures 40 Demo

NASA Image and Video Library

2010-09-15

ISS024-E-014993 (15 Sept. 2010) --- NASA astronaut Tracy Caldwell Dyson, Expedition 24 flight engineer, conducts a demonstration for the "Kids in Space" session for Water Absorption Flight Procedures #40 in the Columbus laboratory of the International Space Station.

"Space flight is utter bilge"

NASA Astrophysics Data System (ADS)

Yeomans, Donald

2004-01-01

Despite skepticism and ridicule from scientists and the public alike, a small handful of dreamers kept faith in their vision of space flight and planned for the day when humanity would break loose from Earth.

Effects of space flight on the immunohistochemical demonstration of connexin 26 and connexin 43 in the postpartum uterus of rats

NASA Technical Reports Server (NTRS)

Burden, H. W.; Zary, J.; Alberts, J. R.

1999-01-01

The effect of space flight in a National Aeronautics and Space Administration shuttle was studied in pregnant rats. Rats were launched on day 11 of gestation and recovered on day 20 of gestation. Pregnancy was allowed to proceed to term and rats delivered vaginally on days 22-23, although flight animals required more labour contractions to complete the delivery process. Pups were placed with foster dams and connexin 26 and 43 were examined in the uterus of flight animals approximately 3 h after delivery. Space flight did not affect uterine connexin 26, localized primarily in epithelial cells of the endometrium, but decreased connexin 43, the major gap junction protein in the myometrium. It is suggested that decreased connexin 43 alters synchronization and coordination of labour contractions, resulting in a requirement for more contractions to complete the delivery process.

Marshall Space Flight Center Technology Capabilities for Use in Space Situational Awareness Activities

NASA Technical Reports Server (NTRS)

Gagliano, Larry; McLeod, Todd; Hovater, Mary A.

2017-01-01

Marshall performs research, integrates information, matures technologies, and enhances science to bring together a diverse portfolio of products and services of interest for Space Situational Awareness (SSA) and Space Asset Management (SAM), all of which can be accessed through partnerships with Marshall. Integrated Space Situational Awareness and Asset Management (ISSAAM) is an initiative of NASA's Marshall Space Flight Center to improve space situational awareness and space asset management through technical innovation, collaboration, and cooperation with U.S. Government agencies and the global space community. Marshall Space Flight Center provides solutions for complex issues with in-depth capabilities, a broad range of experience, and expertise unique in the world, and all available in one convenient location. NASA has longstanding guidelines that are used to assess space objects. Specifically, Marshall Space Flight Center has the capabilities, facilities and expertise to address the challenges that space objects, such as near-Earth objects (NEO) or Orbital Debris pose. ISSAAM's three pronged approach brings together vital information and in-depth tools working simultaneously toward examining the complex problems encountered in space situational awareness. Marshall's role in managing, understanding and planning includes many projects grouped under each prong area: Database/Analyses/Visualization; Detection/Tracking/ Mitigation/Removal. These are not limited to those listed below.

Calculation of Flight Deck Interval Management Assigned Spacing Goals Subject to Multiple Scheduling Constraints

NASA Technical Reports Server (NTRS)

Robinson, John E.

2014-01-01

The Federal Aviation Administration's Next Generation Air Transportation System will combine advanced air traffic management technologies, performance-based procedures, and state-of-the-art avionics to maintain efficient operations throughout the entire arrival phase of flight. Flight deck Interval Management (FIM) operations are expected to use sophisticated airborne spacing capabilities to meet precise in-trail spacing from top-of-descent to touchdown. Recent human-in-the-loop simulations by the National Aeronautics and Space Administration have found that selection of the assigned spacing goal using the runway schedule can lead to premature interruptions of the FIM operation during periods of high traffic demand. This study compares three methods for calculating the assigned spacing goal for a FIM operation that is also subject to time-based metering constraints. The particular paradigms investigated include: one based upon the desired runway spacing interval, one based upon the desired meter fix spacing interval, and a composite method that combines both intervals. These three paradigms are evaluated for the primary arrival procedures to Phoenix Sky Harbor International Airport using the entire set of Rapid Update Cycle wind forecasts from 2011. For typical meter fix and runway spacing intervals, the runway- and meter fix-based paradigms exhibit moderate FIM interruption rates due to their inability to consider multiple metering constraints. The addition of larger separation buffers decreases the FIM interruption rate but also significantly reduces the achievable runway throughput. The composite paradigm causes no FIM interruptions, and maintains higher runway throughput more often than the other paradigms. A key implication of the results with respect to time-based metering is that FIM operations using a single assigned spacing goal will not allow reduction of the arrival schedule's excess spacing buffer. Alternative solutions for conducting the FIM operation

Computational Physics for Space Flight Applications

NASA Technical Reports Server (NTRS)

Reed, Robert A.

2004-01-01

This paper presents viewgraphs on computational physics for space flight applications. The topics include: 1) Introduction to space radiation effects in microelectronics; 2) Using applied physics to help NASA meet mission objectives; 3) Example of applied computational physics; and 4) Future directions in applied computational physics.

Ethernet for Space Flight Applications

NASA Technical Reports Server (NTRS)

Webb, Evan; Day, John H. (Technical Monitor)

2002-01-01

NASA's Goddard Space Flight Center (GSFC) is adapting current data networking technologies to fly on future spaceflight missions. The benefits of using commercially based networking standards and protocols have been widely discussed and are expected to include reduction in overall mission cost, shortened integration and test (I&T) schedules, increased operations flexibility, and hardware and software upgradeability/scalability with developments ongoing in the commercial world. The networking effort is a comprehensive one encompassing missions ranging from small University Explorer (UNEX) class spacecraft to large observatories such as the Next Generation Space Telescope (NGST). Mission aspects such as flight hardware and software, ground station hardware and software, operations, RF communications, and security (physical and electronic) are all being addressed to ensure a complete end-to-end system solution. One of the current networking development efforts at GSFC is the SpaceLAN (Spacecraft Local Area Network) project, development of a space-qualifiable Ethernet network. To this end we have purchased an IEEE 802.3-compatible 10/100/1000 Media Access Control (MAC) layer Intellectual Property (IP) core and are designing a network node interface (NNI) and associated network components such as a switch. These systems will ultimately allow the replacement of the typical MIL-STD-1553/1773 and custom interfaces that inhabit most spacecraft. In this paper we will describe our current Ethernet NNI development along with a novel new space qualified physical layer that will be used in place of the standard interfaces. We will outline our plans for development of space qualified network components that will allow future spacecraft to operate in significant radiation environments while using a single onboard network for reliable commanding and data transfer. There will be a brief discussion of some issues surrounding system implications of a flight Ethernet. Finally, we will

Experiment 305: Pathophysiology of Mineral Loss During Space Flight

NASA Technical Reports Server (NTRS)

Arnaud, Claude D.; Cann, Christopher E.

1995-01-01

The objective of this SLS-2 experiment was to determine the pathophysiology of mineral loss during space flight. This was to be accomplished by (1) determining the concentrations of blood minerals and of calciotropic hormones (parathyroid hormone-PTH, vitamin D metabolites) before, during, and after a 14 day shuttle flight, and (2) determining, by calcium kinetic analysis (using stable calcium isotopes), the influence of space flight on intestinal calcium absorption .

Insulin secretion and sensitivity in space flight: diabetogenic effects

NASA Technical Reports Server (NTRS)

Tobin, Brian W.; Uchakin, Peter N.; Leeper-Woodford, Sandra K.

2002-01-01

Nearly three decades of space flight research have suggested that there are subclinical diabetogenic changes that occur in microgravity. Alterations in insulin secretion, insulin sensitivity, glucose tolerance, and metabolism of protein and amino acids support the hypothesis that insulin plays an essential role in the maintenance of muscle mass in extended-duration space flight. Experiments in flight and after flight and ground-based bedrest studies have associated microgravity and its experimental paradigms with manifestations similar to those of diabetes, physical inactivity, and aging. We propose that these manifestations are characterized best by an etiology that falls into the clinical category of "other" causes of diabetes, including, but not restricted to, genetic beta-cell defects, insulin action defects, diseases of the endocrine pancreas, endocrinopathies, drug or chemically induced diabetes, infections, immune-mediated metabolic alteration, and a host of genetic related diseases. We present data showing alterations in tumor necrosis factor-alpha production, insulin secretion, and amino acid metabolism in pancreatic islets of Langerhans cultured in a ground-based cell culture bioreactor that mimics some of the effects of microgravity. Taken together, space flight research, ground-based studies, and bioreactor studies of pancreatic islets of Langerhans support the hypothesis that the pancreas is unable to overcome peripheral insulin resistance and amino acid dysregulation during space flight. We propose that measures of insulin secretion and insulin action will be necessary to design effective countermeasures against muscle loss, and we advance the "disposition index" as an essential model to be used in the clinical management of space flight-induced muscle loss.

Research and Technology Report. Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Soffen, Gerald (Editor); Truszkowski, Walter (Editor); Ottenstein, Howard (Editor); Frost, Kenneth (Editor); Maran, Stephen (Editor); Walter, Lou (Editor); Brown, Mitch (Editor)

1996-01-01

This issue of Goddard Space Flight Center's annual report highlights the importance of mission operations and data systems covering mission planning and operations; TDRSS, positioning systems, and orbit determination; ground system and networks, hardware and software; data processing and analysis; and World Wide Web use. The report also includes flight projects, space sciences, Earth system science, and engineering and materials.

The 2006 Cape Canaveral Air Force Station Range Reference Atmosphere Model Validation Study and Sensitivity Analysis to the National Aeronautics and Space Administration's Space Shuttle

NASA Technical Reports Server (NTRS)

Decker, Ryan K.; Burns, Lee; Merry, Carl; Harrington, Brian

2008-01-01

Atmospheric parameters are essential in assessing the flight performance of aerospace vehicles. The effects of the Earth's atmosphere on aerospace vehicles influence various aspects of the vehicle during ascent ranging from its flight trajectory to the structural dynamics and aerodynamic heatmg on the vehicle. Atmospheric databases charactenzing the wind and thermodynamic environments, known as Range Reference Atmospheres (RRA), have been developed at space launch ranges by a governmental interagency working group for use by aerospace vehicle programs. The National Aeronantics and Space Administration's (NASA) Space Shuttle Program (SSP), which launches from Kennedy Space Center, utilizes atmosphenc statistics derived from the Cape Canaveral Air Force Station Range Reference Atmosphere (CCAFS RRA) database to evaluate environmental constraints on various aspects of the vehlcle during ascent.

Space Flight Resource Management for ISS Operations

NASA Technical Reports Server (NTRS)

Schmidt, Larry; Slack, Kelley; O'Keefe, William; Huning, Therese; Sipes, Walter; Holland, Albert

2011-01-01

This slide presentation reviews the International Space Station (ISS) Operations space flight resource management, which was adapted to the ISS from the shuttle processes. It covers crew training and behavior elements.

Cell-Mediated Immune Function and Cytokine Regulation During Space Flight

NASA Technical Reports Server (NTRS)

Sams, Clarence F.; Pierson, Duane L.; Paloski, W. H. (Technical Monitor)

2000-01-01

The changes in immune function which occur during space flight potentially expose the crews to an increased risk for development of illness. Decreased cellular immune function has been repeatedly documented after space flight and confirmed during flight by in vivo delayed-type hypersensitivity testing. However, correlation of immune changes with a clinically significant risk factor has not yet been performed. Our hypothesis is that space flight induces a decrease in cell-mediated immune function accompanied by a shift from a type 1 cytokine pattern (favoring cell-mediated immunity) to a type 2 cytokine pattern (favoring humoral immunity). We further hypothesize that reactivation of latent viruses will occur during space flight in association with the decreased cellular immunity. To test these hypotheses, we will determine the effects of space flight on cell-mediated immunity and viral reactivation. We will utilize delayed-type hypersensitivity testing as an in vivo measure of integrated cell-mediated immune function. The production of cytokines and immunoregulatory factors by lymphocytes and monocytes will be measured to determine whether changes in cytokine patterns are associated with the space flight-induced immune dysregulation. Correlation of antigen-specific immune changes with reactivation of latent herpes viruses will be determined by measuring peripheral levels of viral (CMV, VZV, EBV) antigen-specific T cells and comparing to the levels of EBV-infected B-cells by fluorescence in situ hybridization and flow cytometry. A comparison of cell-mediated immune function, cytokine regulation and viral reactivation will provide new insights into crew member health risks during flight.

Deep-Space Ka-Band Flight Experience

NASA Astrophysics Data System (ADS)

Morabito, D. D.

2017-11-01

Lower frequency bands have become more congested in allocated bandwidth as there is increased competition between flight projects and other entities. Going to higher frequency bands offers significantly more bandwidth, allowing for the use of much higher data rates. However, Ka-band is more susceptible to weather effects than lower frequency bands currently used for most standard downlink telemetry operations. Future or prospective flight projects considering deep-space Ka-band (32-GHz) telemetry data links have expressed an interest in understanding past flight experience with received Ka-band downlink performance. Especially important to these flight projects is gaining a better understanding of weather effects from the experience of current or past missions that operated Ka-band radio systems. We will discuss the historical flight experience of several Ka-band missions starting from Mars Observer in 1993 up to present-day deep-space missions such as Kepler. The study of historical Ka-band flight experience allows one to recommend margin policy for future missions. Of particular interest, we will review previously reported-on flight experience with the Cassini spacecraft Ka-band radio system that has been used for radio science investigations as well as engineering studies from 2004 to 2015, when Cassini was in orbit around the planet Saturn. In this article, we will focus primarily on the Kepler spacecraft Ka-band link, which has been used for operational telemetry downlink from an Earth trailing orbit where the spacecraft resides. We analyzed the received Ka-band signal level data in order to characterize link performance over a wide range of weather conditions and as a function of elevation angle. Based on this analysis of Kepler and Cassini flight data, we found that a 4-dB margin with respect to adverse conditions ensures that we achieve at least a 95 percent data return.

Habitability and Behavioral Issues of Space Flight.

ERIC Educational Resources Information Center

Stewart, R. A., Jr.

1988-01-01

Reviews group behavioral issues from past space missions and simulations such as the Skylab Medical Experiments Altitude Test, Skylab missions, and Shuttle Spacelab I mission. Makes recommendations for future flights concerning commandership, crew selection, and ground-crew communications. Pre- and in-flight behavioral countermeasures are…

Space flight and oxidative stress

NASA Technical Reports Server (NTRS)

Stein, T. P.

2002-01-01

Space flight is associated with an increase in oxidative stress after return to 1g. The effect is more pronounced after long-duration space flight. The effects lasts for several weeks after landing. In humans there is increased lipid peroxidation in erythrocyte membranes, reduction in some blood antioxidants, and increased urinary excretion of 8-iso-prostaglandin F(2alpha) and 8-oxo-7,8 dihydro-2 deoxyguanosine. Isoprostane 8-iso-prostaglandin F(2alpha) and 8-oxo-7,8 dihydro-2 deoxyguanosine are markers for oxidative damage to lipids and DNA, respectively. The changes have been attributed to a combination of the energy deficiency that occurs during flight and substrate competition for amino acids occurring between repleting muscle and other tissues during the recovery phase. The observations in humans have been complemented by rodent studies. Most rodent studies showed increased production of lipid peroxidation products postflight and decreased antioxidant enzyme activity postflight. The rodent observations were attributed to the stress associated with reentry into Earth's gravity. Decreasing the imbalance between the production of endogenous oxidant defenses and oxidant production by increasing the supply of dietary antioxidants may lessen the severity of the postflight increase in oxidative stress.

Human Space Flight Plans Committee

NASA Image and Video Library

2009-08-12

Former astronaut Dr. Sally Ride, left, confers with Norman Augustine, chair, prior to the start of the final meeting of the Human Space Flight Review Committee, Wednesday, Aug. 12, 2009, in Washington. Photo Credit: (NASA/Paul E. Alers)

Human Space Flight Plans Committee

NASA Image and Video Library

2009-12-07

Former astronaut Dr. Sally Ride, left, confers with Norman Augustine, chair, prior to the start of the final meeting of the Human Space Flight Review Committee, Wednesday, Aug. 12, 2009, in Washington. Photo Credit: (NASA/Paul E. Alers)

Renal-Stone Risk Assessment During Space Shuttle Flights

NASA Technical Reports Server (NTRS)

Whitson, Peggy A.; Pietrzyk, Robert A.; Pak, Charles Y. C.

1996-01-01

The metabolic and environmental factors influencing renal stone formation before, during, and after Space Shuttle flights were assessed. We established the contributing roles of dietary factors in relationship to the urinary risk factors associated with renal stone formation. 24-hr urine samples were collected prior to, during space flight, and following landing. Urinary factors associated with renal stone formation were analyzed and the relative urinary supersaturation ratios of calcium oxalate, calcium phosphate (brushite), sodium urate, struvite and uric acid were calculated. Food and fluid consumption was recorded for a 48-hr period ending with the urine collection. Urinary composition changed during flight to favor the crystallization of stone-forming salts. Factors that contributed to increased potential for stone formation during space flight were significant reductions in urinary pH and increases in urinary calcium. Urinary output and citrate, a potent inhibitor of calcium-containing stones, were slightly reduced during space flight. Dietary intakes were significantly reduced for a number of variables, including fluid, energy, protein, potassium, phosphorus and magnesium. This is the first in-flight characterization of the renal stone forming potential in astronauts. With the examination of urinary components and nutritional factors, it was possible to determine the factors that contributed to increased risk or protected from risk. In spite of the protective components, the negative contributions to renal stone risk predominated and resulted in a urinary environment that favored the supersaturation of stone-forming salts. The importance of the hypercalciuria was noted since renal excretion was high relative to the intake.

Impact of space flight on bacterial virulence and antibiotic susceptibility

PubMed Central

Taylor, Peter William

2015-01-01

Manned space flight induces a reduction in immune competence among crew and is likely to cause deleterious changes to the composition of the gastrointestinal, nasal, and respiratory bacterial flora, leading to an increased risk of infection. The space flight environment may also affect the susceptibility of microorganisms within the spacecraft to antibiotics, key components of flown medical kits, and may modify the virulence characteristics of bacteria and other microorganisms that contaminate the fabric of the International Space Station and other flight platforms. This review will consider the impact of true and simulated microgravity and other characteristics of the space flight environment on bacterial cell behavior in relation to the potential for serious infections that may appear during missions to astronomical objects beyond low Earth orbit. PMID:26251622

Human factors in long-duration space flight

NASA Technical Reports Server (NTRS)

1972-01-01

A study, covering the behavioral, psychological, physiological, and medical factors of long duration manned space flight, is presented. An attempt was made to identify and resolve major obstacles and unknowns associated with such a flight. The costs and maintenance of the spacecraft system are also explored.

Human Factors in Space Flight

NASA Technical Reports Server (NTRS)

Woolford, Barbara J.; Mount, Frances

2005-01-01

After forty years of experience with human space flight (Table 1), the current emphasis is on the design of space vehicles, habitats, and missions to ensure mission success. What lessons have we learned that will affect the design of spacecraft for future space exploration, leading up to exploring Mars? This chapter addresses this issue in four sections: Anthropometry and Biomechanics; Environmental Factors; Habitability and Architecture; and Crew Personal Sustenance. This introductory section introduces factors unique to space flight. A unique consideration for design of a habitable volume in a space vehicle is the lack of gravity during a space flight, referred to as microgravity. This affects all aspects of life, and drives special features in the habitat, equipment, tools, and procedures. The difference in gravity during a space mission requires designing for posture and motion differences. In Earth s gravity, or even with partial gravity, orientation is not a variable because the direction in which gravity acts defines up and down. In a microgravity environment the working position is arbitrary; there is no gravity cue. Orientation is defined primarily through visual cues. The orientation within a particular crew station or work area is referred to as local vertical, and should be consistent within a module to increase crew productivity. Equipment was intentionally arranged in various orientations in one module on Skylab to assess the efficiency in use of space versus the effects of inconsistent layout. The effects of that arrangement were confusion on entering the module, time spent in re-orientation, and conflicts in crew space requirements when multiple crew members were in the module. Design of a space vehicle is constrained by the three major mission drivers: mass, volume and power. Each of these factors drives the cost of a mission. Mass and volume determine the size of the launch vehicle directly; they can limit consumables such as air, water, and

Postural Responses Following Space Flight and Ground Based Analogs

NASA Technical Reports Server (NTRS)

Kofman, Igor S.; Reschke, Millard F.; Cerisano, Jody M.; Fisher, Elizabeth A.; Tomilovskaya, Elena V.; Kozlovskaya, Inessa B.; Bloomberg, Jacob B.

2013-01-01

With the transition from the Shuttle program to the International Space Station (ISS), the opportunity to fly sensorimotor experiments in a weightless environment has become increasingly more difficult to obtain. As a result, more investigations have turned to ground-based analogs as a way of evaluating an experiment's viability. The two primary analogs available to most investigators are 6deg head down bed rest (HDBR) and dry immersion (DI). For the time being, HDBR investigations have been associated with studies conducted in the United States while the Russians and several other European Union states have concentrated their efforts on using DI as the space flight analog of choice. While either model may be viable for cardiovascular, bone and other system changes, vestibular and sensorimotor investigators have retained serious reservations of either analog's potential to serve as a replacement for a true weightless environment. These reservations have merit, but it is worthwhile to consider that not all changes associated with sensorimotor function during space flight are the result of top-down modifications, but may also be due to the lack, or change, of appropriate support surfaces applying force to the bottom of the feet. To this end we have compared quiet stance postural responses between short duration Space Shuttle flights, long duration ISS flights and HDBR of varying duration. Using these three platforms, representing different modifications of support we investigated postural ataxia using a quiet stance model. Quiet stance was obtained by asking the subjects to stand upright on a force plate, eyes open, arms at the side of the body for three min. From the force plate we obtained average sway velocity in two axes as well as length of line (stabilogram). These parameters were then related to EMG activity recorded from the medial gastrocnemius and lateral tibialis. It is significant to note that postural ataxia measured as quiet stance shows analogous

14 CFR 23.1303 - Flight and navigation instruments.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Flight and navigation instruments. 23.1303 Section 23.1303 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... General § 23.1303 Flight and navigation instruments. The following are the minimum required flight and...

14 CFR 23.1303 - Flight and navigation instruments.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Flight and navigation instruments. 23.1303 Section 23.1303 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... General § 23.1303 Flight and navigation instruments. The following are the minimum required flight and...

Sleep, performance, circadian rhythms, and light-dark cycles during two space shuttle flights

NASA Technical Reports Server (NTRS)

Dijk, D. J.; Neri, D. F.; Wyatt, J. K.; Ronda, J. M.; Riel, E.; Ritz-De Cecco, A.; Hughes, R. J.; Elliott, A. R.; Prisk, G. K.; West, J. B.;

Body Fluid Regulation and Hemopoiesis in Space Flight

NASA Technical Reports Server (NTRS)

1997-01-01

In this session, Session JA2, the discussion focuses on the following topics: Bodymass and Fluid Distribution During Longterm Spaceflight with and without Countermeasures; Plasma Volume, Extracellular Fluid Volume, and Regulatory Hormones During Long-Term Space Flight; Effect of Microgravity and its Ground-Based Models on Fluid Volumes and Hemocirculatory Volumes; Seventeen Weeks of Horizontal Bed Rest, Lower Body Negative Pressure Testing, and the Associated Plasma Volume Response; Evaporative Waterloss in Space Theoretical and Experimental Studies; Erythropoietin Under Real and Simulated Micro-G Conditions in Humans; and Vertebral Bone Marrow Changes Following Space Flight.

14 CFR 460.45 - Operator informing space flight participant of risk.

Code of Federal Regulations, 2014 CFR

2014-01-01

... understanding of the hazards and risks of the mission, and each space flight participant must then provide... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Operator informing space flight participant of risk. 460.45 Section 460.45 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL...

14 CFR 460.45 - Operator informing space flight participant of risk.

Code of Federal Regulations, 2013 CFR

2013-01-01

... understanding of the hazards and risks of the mission, and each space flight participant must then provide... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Operator informing space flight participant of risk. 460.45 Section 460.45 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL...

14 CFR 460.45 - Operator informing space flight participant of risk.

Code of Federal Regulations, 2012 CFR

2012-01-01

... understanding of the hazards and risks of the mission, and each space flight participant must then provide... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Operator informing space flight participant of risk. 460.45 Section 460.45 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL...

Space flight rehabilitation.

PubMed

Payne, Michael W C; Williams, David R; Trudel, Guy

2007-07-01

The weightless environment of space imposes specific physiologic adaptations on healthy astronauts. On return to Earth, these adaptations manifest as physical impairments that necessitate a period of rehabilitation. Physiologic changes result from unloading in microgravity and highly correlate with those seen in relatively immobile terrestrial patient populations such as spinal cord, geriatric, or deconditioned bed-rest patients. Major postflight impairments requiring rehabilitation intervention include orthostatic intolerance, bone demineralization, muscular atrophy, and neurovestibular symptoms. Space agencies are preparing for extended-duration missions, including colonization of the moon and interplanetary exploration of Mars. These longer-duration flights will result in more severe and more prolonged disability, potentially beyond the point of safe return to Earth. This paper will review and discuss existing space rehabilitation plans for major postflight impairments. Evidence-based rehabilitation interventions are imperative not only to facilitate return to Earth but also to extend the safe duration of exposure to a physiologically hostile microgravity environment.

Integration Testing of Space Flight Systems

NASA Technical Reports Server (NTRS)

Honeycutt, Timothy; Sowards, Stephanie

2008-01-01

Based on the previous success' of Multi-Element Integration Testing (MEITs) for the International Space Station Program, these type of integrated tests have also been planned for the Constellation Program: MEIT (1) CEV to ISS (emulated) (2) CEV to Lunar Lander/EDS (emulated) (3) Future: Lunar Surface Systems and Mars Missions Finite Element Integration Test (FEIT) (1) CEV/CLV (2) Lunar Lander/EDS/CaL V Integrated Verification Tests (IVT) (1) Performed as a subset of the FEITs during the flight tests and then performed for every flight after Full Operational Capability (FOC) has been obtained with the flight and ground Systems.

14 CFR 125.363 - Flight release over water.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight release over water. 125.363 Section 125.363 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... Flight release over water. (a) No person may release an airplane for a flight that involves extended...

14 CFR 125.363 - Flight release over water.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight release over water. 125.363 Section 125.363 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... Flight release over water. (a) No person may release an airplane for a flight that involves extended...

14 CFR 125.363 - Flight release over water.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight release over water. 125.363 Section 125.363 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... Flight release over water. (a) No person may release an airplane for a flight that involves extended...

14 CFR 125.363 - Flight release over water.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight release over water. 125.363 Section 125.363 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... Flight release over water. (a) No person may release an airplane for a flight that involves extended...

14 CFR 125.363 - Flight release over water.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight release over water. 125.363 Section 125.363 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... Flight release over water. (a) No person may release an airplane for a flight that involves extended...

Neuromuscular activation patterns during treadmill walking after space flight

NASA Technical Reports Server (NTRS)

Layne, C. S.; McDonald, P. V.; Bloomberg, J. J.

1997-01-01

Astronauts adopt a variety of neuromuscular control strategies during space flight that are appropriate for locomoting in that unique environment, but are less than optimal upon return to Earth. We report here the first systematic investigation of potential adaptations in neuromuscular activity patterns associated with postflight locomotion. Astronaut-subjects were tasked with walking on a treadmill at 6.4 km/h while fixating a visual target 30 cm away from their eyes after space flights of 8-15 days. Surface electromyography was collected from selected lower limb muscles and normalized with regard to mean amplitude and temporal relation to heel strike. In general, high correlations (more than 0.80) were found between preflight and postflight activation waveforms for each muscle and each subject: however relative activation amplitude around heel strike and toe off was changed as a result of flight. The level of muscle cocontraction and activation variability, and the relationship between the phasic characteristics of the ankle musculature in preparation for toe off also were altered by space flight. Subjects also reported oscillopsia during treadmill walking after flight. These findings indicate that, after space flight, the sensory-motor system can generate neuromuscular-activation strategies that permit treadmill walking, but subtle changes in lower-limb neuromuscular activation are present that may contribute to increased lower limb kinematic variability and oscillopsia also present during postflight walking.

14 CFR 417.213 - Flight safety limits analysis.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Flight safety limits analysis. 417.213 Section 417.213 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... launch vehicle's flight to prevent the hazardous effects of the resulting debris impacts from reaching...

14 CFR 417.213 - Flight safety limits analysis.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Flight safety limits analysis. 417.213 Section 417.213 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... launch vehicle's flight to prevent the hazardous effects of the resulting debris impacts from reaching...

14 CFR 417.213 - Flight safety limits analysis.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Flight safety limits analysis. 417.213 Section 417.213 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... launch vehicle's flight to prevent the hazardous effects of the resulting debris impacts from reaching...

14 CFR 417.213 - Flight safety limits analysis.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Flight safety limits analysis. 417.213 Section 417.213 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... launch vehicle's flight to prevent the hazardous effects of the resulting debris impacts from reaching...

14 CFR 417.213 - Flight safety limits analysis.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Flight safety limits analysis. 417.213 Section 417.213 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... launch vehicle's flight to prevent the hazardous effects of the resulting debris impacts from reaching...

Immune resistance of man in space flights

NASA Astrophysics Data System (ADS)

Irina, V.; Konstantinova, M. D.

The immune system of 72 cosmonauts was studied after their flights on board Salyut 6, 7 and Mir orbital stations. PHA lymphocyte reactivity, T helper activity and NK capacity to recognize and kill the target were decreased on 1-7 days after prolonged (3-11 months) space flights. Certain alterations were found in the ultrastructure of the NK secretory and locomotor apparatuses. Decrement of IL 2 production was shown using the biological test. However immunoenzymatic analysis did not reveal a decrease in IL 2 synthesis. Production of α-interferon remained unchanged while that of γ-interferon either rose or was diminished. Several cosmonanauts displayed a trend towards increased OAF production. The observed decrease in immune system functioning may increase the risk of various diseases during prolonged space flights.

Increased Renal Solute Excretion in Rats Following Space Flight

NASA Technical Reports Server (NTRS)

Wade, Charles E.; Moore, A. L.; Morey-Holton, E.

1995-01-01

Following space flight a diuresis, due to an increase in free water clearance, has been suggested in humans. To assess the effects of space flight on renal function, rats were flown in space for 14 days. Rats were divided into three groups; vivarium controls (V;n=6; housed 2/shoe box cage), flight controls (FC;n=6; group housed in a flight cage), and flight animals (F;n=6). Upon landing all animals were placed into individual metabolic cages. Urine was collected daily for 7 days and every other day for 14 days. Urine output was increased (p less than 0.05; ANOVA) following flight for 3 days. On postflight day 1, flow rates were, V=6.8 plus or minus 0.9, FC=8.711.8 and F=16.6 plus or minus 2.7 microliter/min. Excretion rates of Na+ and K+ were increased, resulting in an increased osmotic excretion rate (V=7.9 plus or minus 0.9, FC=6.1 plus or minus 0.7 and F=13.5 plus or minus 0.7 uOsm/min). Creatinine excretion rate was increased over the first two postflight days. In the absence of changes in plasma creatinine, Na+, or K+ (samples obtained immediately post flight from similar rats compared to Day 14), GFR was increased following space flight. The increased excretion of solute was thus the result of increased delivery and decreased reabsorption. Osmotic clearance was increased (V=28, FC=27 and F=51 microliter/min), while free water clearance was decreased post flight (V=-21,FC=-18 and F=-34 microliter/min). In rats, the postflight diuresis is the result of an increase in solute (osmotic) excretion with an accompanying reduction in free water clearance.

14 CFR 141.41 - Flight simulators, flight training devices, and training aids.

Code of Federal Regulations, 2014 CFR

2014-01-01

..., and training aids. 141.41 Section 141.41 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... aids. An applicant for a pilot school certificate or a provisional pilot school certificate must show that its flight simulators, flight training devices, training aids, and equipment meet the following...

14 CFR 141.41 - Flight simulators, flight training devices, and training aids.

Code of Federal Regulations, 2011 CFR

2011-01-01

..., and training aids. 141.41 Section 141.41 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... aids. An applicant for a pilot school certificate or a provisional pilot school certificate must show that its flight simulators, flight training devices, training aids, and equipment meet the following...

14 CFR 141.41 - Flight simulators, flight training devices, and training aids.

Code of Federal Regulations, 2012 CFR

2012-01-01

..., and training aids. 141.41 Section 141.41 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... aids. An applicant for a pilot school certificate or a provisional pilot school certificate must show that its flight simulators, flight training devices, training aids, and equipment meet the following...

14 CFR 141.41 - Flight simulators, flight training devices, and training aids.

Code of Federal Regulations, 2013 CFR

2013-01-01

..., and training aids. 141.41 Section 141.41 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... aids. An applicant for a pilot school certificate or a provisional pilot school certificate must show that its flight simulators, flight training devices, training aids, and equipment meet the following...

Human Space Flight Plans Committee

NASA Image and Video Library

2009-08-11

Dr. Edward Crawley, Ford Professor of Engineering at MIT and co-chair, NASA Exploration Technology Development Program Review Committee speaks during the final meeting of the Human Space Flight Review Committee, Wednesday, Aug. 12, 2009, in Washington. Photo Credit: (NASA/Paul E. Alers)

NASA Tests 2nd RS-25 Flight Engine for Space Launch System

NASA Image and Video Library

2018-01-16

On Jan. 16, 2018, engineers at NASA’s Stennis Space Center in Mississippi conducted a certification test of another RS-25 engine flight controller on the A-1 Test Stand at Stennis Space Center. The 365-second, full-duration test came a month after the space agency capped a year of RS-25 testing with a flight controller test in mid-December. For the “green run” test the flight controller was installed on RS-25 developmental engine E0528 and fired just as during an actual launch. Once certified, the flight controller will be removed and installed on a flight engine for use by NASA’s new deep-space rocket, the Space Launch System (SLS).

Scientific involvement in Skylab by the Space Sciences Laboratory of the Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Winkler, C. E. (Editor)

1973-01-01

The involvement of the Marshall Space Flight Center's Space Sciences Laboratory in the Skylab program from the early feasibility studies through the analysis and publication of flight scientific and technical results is described. This includes mission operations support, the Apollo telescope mount, materials science/manufacturing in space, optical contamination, environmental and thermal criteria, and several corollary measurements and experiments.

14 CFR 63.23 - Special purpose flight engineer and flight navigator certificates: Operation of U.S.-registered...

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Special purpose flight engineer and flight navigator certificates: Operation of U.S.-registered civil airplanes leased by a person not a U.S. citizen. 63.23 Section 63.23 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF...

14 CFR 63.23 - Special purpose flight engineer and flight navigator certificates: Operation of U.S.-registered...

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Special purpose flight engineer and flight navigator certificates: Operation of U.S.-registered civil airplanes leased by a person not a U.S. citizen. 63.23 Section 63.23 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF...

14 CFR 63.23 - Special purpose flight engineer and flight navigator certificates: Operation of U.S.-registered...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Special purpose flight engineer and flight navigator certificates: Operation of U.S.-registered civil airplanes leased by a person not a U.S. citizen. 63.23 Section 63.23 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF...

14 CFR 63.23 - Special purpose flight engineer and flight navigator certificates: Operation of U.S.-registered...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Special purpose flight engineer and flight navigator certificates: Operation of U.S.-registered civil airplanes leased by a person not a U.S. citizen. 63.23 Section 63.23 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF...

14 CFR 63.23 - Special purpose flight engineer and flight navigator certificates: Operation of U.S.-registered...

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Special purpose flight engineer and flight navigator certificates: Operation of U.S.-registered civil airplanes leased by a person not a U.S. citizen. 63.23 Section 63.23 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF...

Technology Validation of Optical Fiber Cables for Space Flight Environments

NASA Technical Reports Server (NTRS)

Ott, Melanie N.; Friedberg, Patricia; Day, John H. (Technical Monitor)

2000-01-01

Periodically, commercially available (COTS) optical fiber cable assemblies are characterized for space flight usage under the NASA Electronic Parts and Packaging Program (NEPP). The purpose of this is to provide a family of optical fiber cable options to a variety of different harsh environments typical to space flight missions. The optical fiber cables under test are evaluated to bring out known failure mechanisms that are expected to occur during a typical mission. The tests used to characterize COTS cables include: (1) vacuum exposure, (2) thermal cycling, and (3) radiation exposure. Presented here are the results of the testing conducted at NASA Goddard Space Flight Center on COTS optical fiber cables over this past year. Several optical fiber cables were characterized for their thermal stability both during and after thermal cycling. The results show how much preconditioning is necessary for a variety of available cables to remain thermally stable in a space flight environment. Several optical fibers of dimensions 100/140/172 microns were characterized for their radiation effects at -125 C using the dose rate requirements of International Space Station. One optical fiber cable in particular was tested for outgassing to verify whether an acrylate coated fiber could be used in a space flight optical cable configuration.

Looking Up: Multimedia about Space and Flight.

ERIC Educational Resources Information Center

Walter, Virginia A.

1998-01-01

The best CD-ROMs for young people about space and flight exploit the promise of hypermedia to create informative simulations. This article provides an annotated bibliography of CD-ROMs on astronomy and flight for K-12 students; suggests book and Internet connections; and highlights poetry for astronomers, science fiction, a biography of Charles…

Postnatal development under conditions of simulated weightlessness and space flight

NASA Technical Reports Server (NTRS)

Walton, K.

1998-01-01

The adaptability of the developing nervous system to environmental influences and the mechanisms underlying this plasticity has recently become a subject of interest in space neuroscience. Ground studies on neonatal rats using the tail suspension model of weightlessness have shown that the force of gravity clearly influences the events underlying the postnatal development of motor function. These effects depend on the age of the animal, duration of the perturbation and the motor function studied. A nine-day flight study has shown that a dam and neonates can develop under conditions of space flight. The motor function of the flight animals after landing was consistent with that seen in the tail suspension studies, being marked by limb joint extension. However, there were expected differences due to: (1) the unloading of the vestibular system in flight, which did not occur in the ground-based experiments; (2) differences between flight and suspension durations; and (3) the inability to evaluate motor function during the flight. The next step is to conduct experiments in space with the flexibility and rigor that is now limited to ground studies: an opportunity offered by the International Space Station. Copyright 1998 Published by Elsevier Science B.V.

Human Space Flight Plans Committee

NASA Image and Video Library

2009-08-11

Dr. Wanda Austin, president and CEO of the Aerospace Corp., left, asks a question during the final meeting of the Human Space Flight Review Committee, Wednesday, Aug. 12, 2009, in Washington as committee member Bohdan Bejmuk reviews his notes. Photo Credit: (NASA/Paul E. Alers)

[Doctor, may I travel in space? Aeromedical considerations regarding commercial suborbital space flights].

PubMed

Haerkens, Marck H T M; Simons, Ries; Kuipers, André

2011-01-01

Within a few years, the first commercial operators will start flying passengers on suborbital flights to the verge of space. Medical data on the effects of space journeys on humans have mainly been provided by professional astronauts. There is very little research into the aeromedical consequences of suborbital flights for the health of untrained passengers. Low air pressure and oxygen tension can be compensated for by pressurising the spacecraft or pressure suit. Rapid changes in gravitational (G-)force pose ultimate challenges to cardiovascular adaptation mechanisms. Zero-gravity and G-force may cause motion sickness. Vibrations and noise during the flight may disturb communication between passengers and crew. In addition, the psychological impact of a suborbital flight should not be underestimated. There are currently no legal requirements available for medical examinations for commercial suborbital flights, but it seems justifiable to establish conditions for potential passengers' states of health.

In-flight simulation studies at the NASA Dryden Flight Research Facility

NASA Technical Reports Server (NTRS)

Shafer, Mary F.

1992-01-01

Since the late 1950's, the National Aeronautics and Space Administration's Dryden Flight Research Facility has found in-flight simulation to be an invaluable tool. In-flight simulation has been used to address a wide variety of flying qualities questions, including low-lift-to-drag ratio approach characteristics for vehicles like the X-15, the lifting bodies, and the Space Shuttle; the effects of time delays on controllability of aircraft with digital flight-control systems, the causes and cures of pilot-induced oscillation in a variety of aircraft, and flight-control systems for such diverse aircraft as the X-15 and the X-29. In-flight simulation has also been used to anticipate problems and to avoid them and to solve problems once they appear. Presented here is an account of the in-flight simulation at the Dryden Flight Research Facility and some discussion. An extensive bibliography is included.

In-flight simulation studies at the NASA Dryden Flight Research Facility

NASA Technical Reports Server (NTRS)

Shafer, Mary F.

1994-01-01

Since the late 1950's the National Aeronautics and Space Administration's Dryden Flight Research Facility has found in-flight simulation to be an invaluable tool. In-flight simulation has been used to address a wide variety of flying qualities questions, including low lift-to-drag ratio approach characteristics for vehicles like the X-15, the lifting bodies, and the space shuttle; the effects of time delays on controllability of aircraft with digital flight control systems; the causes and cures of pilot-induced oscillation in a variety of aircraft; and flight control systems for such diverse aircraft as the X-15 and the X-29. In-flight simulation has also been used to anticipate problems, avoid them, and solve problems once they appear. This paper presents an account of the in-flight simulation at the Dryden Flight Research Facility and some discussion. An extensive bibliography is included.

Blood and clonogenic hemopoietic cells of newts after the space flight

NASA Astrophysics Data System (ADS)

Michurina, T. V.; Domaratskaya, E. I.; Nikonova, T. M.; Khrushchov, N. G.

Ribbed newts were used for studying the effect of space flight on board of the biosatellite (Cosmos-2229) on blood and clonogenic hemopoietic cells. In blood of newts of the flight group, the relative proportion of neutrophils increased, whereas that of lymphocytes and eosinophils decreased. Space flight did not result in loss of the ability of newt blood cells to incorporate H^3-thymidine. Analysis of clonogenic hemopoietic cells was performed using the method of hemopoietic colony formation on cellulose acetate membranes implanted into the peritoneal cavity of irradiated newts. To analyze reconstitution of hemopoiesis after irradiation donor hemopoietic cells from flight or control newts were transplanted into irradiated newts whose hemopoietic organs were investigated. The newt can be considered an adequate model for studying hemopoiesis under the conditions of the space flight. Previous studies on rats subjected to 5- to 19-day space flights revealed a decrease in the number of clonogenic cells in their hemopoietic organs accompanied by specific changes in the precursor cell compartment and in blood /1,2/. Hence, it was interesting to analyze blood and hemopoietic tissue of lower vertebrates after a space flight and to compare the response to it of animals belonging to different taxonomic groups. We analyzed blood and clonogenic hemopoietic cells of ribbed newts, Pleurodeles waltl (age one year, weight 20-28 g) subjected to a 12-day space flight on board of a Cosmos-2229 biosatellite. The same animals were used in studies on limb and lens regeneration. The results were compared with those obtained with control groups of newts: (1) basic control, operated newts sacrificed on the day of biosatellite launching (BC); (2) synchronous control, operated newts kept in the laboratory under simulated space flight conditions (SC); and (3) intact newts (IC).

Bisphosphonates as a Countermeasure to Space Flight Induced Bone Loss

NASA Technical Reports Server (NTRS)

LeBlanc, A.; Matsumoto, T.; Jones, J.; Shapiro, J.; Lang, T.; Shackelford, L.; Smith, S.; Evans, H.; Spector, E.; Ploutz-Snyder, R.;

View of human problems to be addressed for long-duration space flights

NASA Technical Reports Server (NTRS)

Berry, C. A.

1973-01-01

Review of the principal physiological changes seen in space flight, and discussion of various countermeasures which may prove to be useful in combating these changes in long-term space flight. A number of transient changes seen in Apollo astronauts following space flights are discussed, including cardiovascular and hemodynamic responses to weightlessness, musculoskeletal changes, changes in fluid and electrolyte balance, microbiological changes, and vestibular effects. A number of countermeasures to the effects of space flight on man are cited, including exercise, medication, diet, lower-body negative pressure, gradient positive pressure, venous occlusion cuffs, and others. A detailed review is then made of a number of psychological factors bearing on the ability of the human organism to withstand the rigors of long space flights.

Calcium Balance in Mature Rats Exposed to a Space Flight Model

NASA Technical Reports Server (NTRS)

Wolinsky, Ira

1996-01-01

Negative calcium balances are seen in humans during spaceflight and bed rest, an analog of space flight. Due to the infrequency and costliness of space flight and the difficulties, cost, and restraints in using invasive procedures in bed rest studies, several ground based animal models of space flight have been employed. The most useful and well developed of these models is hind limb unloading in the rat. In this model the hind limbs are non-weight bearing (unloaded) but still mobile; there is a cephalad fluid shift similar to that seen in astronauts in flight; the animals are able to feed, groom and locomote using their front limbs; the procedure is reversible; and, importantly, the model has been validated by comparison to space flight. Several laboratories have studied calcium balance using rats in hind limb unweighting. Roer and Dillaman used young male rats to study calcium balance in this model for 25 days. They found no differences in dietary calcium intake, percent calcium absorption, urinary and fecal excretion, hence indicating no differences in calcium balance between control and unloaded rats. In another study, employing 120 day old females, rats' hind limbs were unloaded for 28 days. While negative calcium balances were observed during a 25 day recovery period no balance measurements were possible during unweighting since the researchers did not employ appropriate metabolic cages. In a recent study from this laboratory, using 200 g rats in the space flight model for two weeks, we found depressed intestinal calcium absorption and increased fecal calcium excretion (indicating less positive calcium balances) and lower circulating 1,25-dihydroxyvitamin D. The above studies indicate that there remains a dearth of information on calcium balance during the hind limb unloading rat space flight model, especially in mature rats, whose use is a better model for planned manned space flight than juvenile or growing animals. With the aid of a newly designed

Origin of Marshall Space Flight Center (MSFC)

NASA Image and Video Library

1960-07-01

The Marshall Space Flight Center was activated on July 1, 1960 as a part of NASA, which had been established on October 1, 1958 by Congressional passage of the National Aeronautics and Space Act. The nucleus of NASA was the Advisory Committee for Aeronautics later named the National Advisory Committee for Aeronauts (NACA). The NACA was founded in 1915 to study the problems of flight and to recommend practical solutions to basic aircraft design and construction problems. NACA's wind turnels and other research facilities made NACA technical reports the basis for aviation progress for more than 40 years.

Cosmonauts' haemostasis system status before and after space flights

NASA Astrophysics Data System (ADS)

Kuzichkin, Dmitry; Markin, Andrey; Morukov, Boris

Introduction. It is known that cosmonauts expose themselves to psychophysical effort in different phases of space flights as well as in pre- and post-flight period. Stress affects different body systems functioning changes including haemostasis system. It is shown that adrenalin directly activates XII coagulation cascade factor [McKay D. G., Latour I. G., Parrish M. N.,1970], initiating intrinsic clotting pathway and affects fibrinogen concentration increase in plasma [Zubairov D. M., 1978]. A post-flight increase in the fibrinogen concentration was revealed with its drop up to the pre-flight level within rehabilitation period [T. Peter Stein, Margaret D., 2006]. Stress agents influence on haemostasis system is physiologically determined and directed to body preparation before probable blood loss. One can consider this process as a function of intrinsic clotting pathway. But in case of blood loss absence the preliminary permanent coagulation activation can lead to appearance of thrombosis risk. Purpose. The purpose was to study haemostasis system main components functional activity features before and after space flights. Methods. In the citrated plasma of astronauts who performed short-term (10 to 11 days) or long-term (196 to 199 days) the following values were determined: activated partial thrombin time (APTT); prothrombin time; prothrombin index; international normalized ratio; thrombin time (TT); activity of enzymes influencing the function of proteins involved in the formation and lysis of a clot such as antithrombin III, protein C, plasminogen, antiplasmin; content of fibrinogen, as well as intermediate products of formation and degradation of fibrin such as D-dimer, soluble fibrin-monomer complexes (SFMC). Sampling of biomaterial was perfomed 30 to 45 days prior to the flight, during the 1st day of the post flight period (all the examined persons), and in the 7th and 14th day (long-term flights member only) Results. In pre-flight period cosmonauts’ APTT

Space flight calcium: implications for astronaut health, spacecraft operations, and Earth.

PubMed

Smith, Scott M; McCoy, Torin; Gazda, Daniel; Morgan, Jennifer L L; Heer, Martina; Zwart, Sara R

2012-12-18

The space flight environment is known to induce bone loss and, subsequently, calcium loss. The longer the mission, generally the more bone and calcium are lost. This review provides a history of bone and calcium studies related to space flight and highlights issues related to calcium excretion that the space program must consider so that urine can be recycled. It also discusses a novel technique using natural stable isotopes of calcium that will be helpful in the future to determine calcium and bone balance during space flight.

14 CFR 121.689 - Flight release form: Supplemental operations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight release form: Supplemental operations. 121.689 Section 121.689 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... the flight is released. (b) The aircraft flight release must contain, or have attached to it, weather...

14 CFR 121.689 - Flight release form: Supplemental operations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight release form: Supplemental operations. 121.689 Section 121.689 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... the flight is released. (b) The aircraft flight release must contain, or have attached to it, weather...

14 CFR 121.689 - Flight release form: Supplemental operations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight release form: Supplemental operations. 121.689 Section 121.689 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... the flight is released. (b) The aircraft flight release must contain, or have attached to it, weather...

14 CFR 121.689 - Flight release form: Supplemental operations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight release form: Supplemental operations. 121.689 Section 121.689 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... the flight is released. (b) The aircraft flight release must contain, or have attached to it, weather...

14 CFR 121.689 - Flight release form: Supplemental operations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight release form: Supplemental operations. 121.689 Section 121.689 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... the flight is released. (b) The aircraft flight release must contain, or have attached to it, weather...

Sub-orbital commercial Human space flight and informed consent in the United States

NASA Astrophysics Data System (ADS)

Carminati, Maria-Vittoria « Giugi »; Griffith, Doug; Campbell, Mark R.

2013-12-01

Commercial space flight is expected to rapidly develop in the near future. This will begin with sub-orbital missions and then progress to orbital flights. In the United States, technical informed consent of space flight participants is required by the commercial space flight operator for regulatory purposes. Additionally, though not required by U.S. regulation, the aerospace medicine professional involved in the medical screening of both space flight participants and crewmembers will be asked to assist operators in obtaining medical informed consent for liability purposes. The various US federal and state regulations regarding informed consent for sub-orbital commercial space flight are evolving and are unfamiliar to most aerospace medical professionals and are reviewed and discussed.

Changes in gastric myoelectric activity during space flight

NASA Technical Reports Server (NTRS)

Harm, Deborah L.; Sandoz, Gwenn R.; Stern, Robert M.

2002-01-01

The purpose of the present study was to examine postprandial myoelectric activity of the stomach and gastric activity associated with space motion sickness using electrogastrography. Three crewmembers participated in this investigation. Preflight, subjects exhibited normal postprandial responses to the ingestion of a meal. Inflight, crewmembers exhibited an abnormal decrease in the power of the normal gastric slow wave after eating on flight day 1, but had a normal postprandial response by flight day 3. Prior to and during episodes of nausea and vomiting, the electrical activity of the stomach became dysrhythmic with 60-80% of the spectral power in the bradygastric and tachygastric frequency ranges. These findings indicate that gastric motility may be decreased during the first few days of space flight. In addition, changes in the frequency of the gastric slow wave associated with space motion sickness symptoms are consistent with those reported for laboratory-induced motion sickness.

Effect of space flight and head-down bedrest on neuroendocrine response to metabolic stress in physically trained subjects.

PubMed

Kvetnanský, R; Ksinantová, L; Koska, J; Noskov, V B; Vigas, M; Grigoriev, A I; Macho, L

2004-07-01

The aim of this study was to evaluate the association of plasma epinephrine (EPI) and norepinephrine (NE) responses to insulin induced hypoglycemia (ITT) 3 weeks before the space flight (SF), on the 5th day of SF, on the 2nd and 16th days after the landing in the first Slovak astronaut, and before and on the 5th day of prolonged subsequent head-down (-6 degrees) bed rest (BR) in 15 military aircraft pilots. Blood samples during the test were collected via cannula inserted into cubital vein, centrifuged in the special appliance Plasma-03, frozen in Kryogem-03, and at the end of the 8-day space flight transferred to Earth in special container for hormonal analysis. Insulin hypoglycemia was induced by i.v. administration of 0.1 IU/kg BW insulin (Actrapid HM) in bolus. Insulin administration led to a comparable hypoglycemia in pre-flight, in-flight conditions and before and after bed rest. ITT led to a pronounced increase in EPI levels and moderate increase in NE in pre-flight studies. However, an evidently reduced EPI response was found after insulin administration during SF and during BR. Thus, during the real microgravity in SF and simulated microgravity in BR, insulin-induced hypoglycemia activates the adrenomedullary system to less extent than at conditions of the Earth gravitation. Post-flight changes in EPI and NE levels did not significantly differ from those of pre-flight since SF was relatively short (8 days) and the readaptation to Earth gravitation was fast. It seems, that an increased blood flow in brain might be responsible for the reduced EPI response to insulin. Responses to ITT in physically fit subjects indicate the stimulus specificity of deconditioning effect of 5 days bed rest on stress response. Thus, the data indicate that catecholamine responses to ITT are reduced after exposure to real as well as simulated microgravity.

Bone Density Following Long Duration Space Flight and Recovery

NASA Technical Reports Server (NTRS)

Amin, Shreyasee; Achenbach, Sara J.; Atkinson, Elizabeth J.; Melton, L. Joseph; Khosla, Sundeep; Sibonga, Jean

2010-01-01

At approx.12 months, Bone Mineral Density (BMD) at most sites in men remained lower than would be predicted, raising concerns for long-term bone health consequences following space flight. Additional analyses based on longer follow-up are being conducted. Although the N is too small for definitive conclusions, women had lower rates of loss at load-bearing sites of the hip and spine immediately post-flight relative to men and smaller differences between observed vs. predicted BMD at most sites, both immediately and 12 months post-flight, relative to men. The role of other exposures/risk factors need to be explored to further understand these possible gender differences in BMD loss and recovery following long-duration space flight.

14 CFR 63.43 - Flight engineer courses.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Flight engineer courses. 63.43 Section 63...) AIRMEN CERTIFICATION: FLIGHT CREWMEMBERS OTHER THAN PILOTS Flight Engineers § 63.43 Flight engineer courses. An applicant for approval of a flight engineer course must submit a letter to the Administrator...

14 CFR 63.61 - Flight navigator courses.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Flight navigator courses. 63.61 Section 63...) AIRMEN CERTIFICATION: FLIGHT CREWMEMBERS OTHER THAN PILOTS Flight Navigators § 63.61 Flight navigator courses. An applicant for approval of a flight navigator course must submit a letter to the Administrator...

14 CFR 63.61 - Flight navigator courses.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Flight navigator courses. 63.61 Section 63...) AIRMEN CERTIFICATION: FLIGHT CREWMEMBERS OTHER THAN PILOTS Flight Navigators § 63.61 Flight navigator courses. An applicant for approval of a flight navigator course must submit a letter to the Administrator...

14 CFR 63.43 - Flight engineer courses.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Flight engineer courses. 63.43 Section 63...) AIRMEN CERTIFICATION: FLIGHT CREWMEMBERS OTHER THAN PILOTS Flight Engineers § 63.43 Flight engineer courses. An applicant for approval of a flight engineer course must submit a letter to the Administrator...

14 CFR 63.61 - Flight navigator courses.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Flight navigator courses. 63.61 Section 63...) AIRMEN CERTIFICATION: FLIGHT CREWMEMBERS OTHER THAN PILOTS Flight Navigators § 63.61 Flight navigator courses. An applicant for approval of a flight navigator course must submit a letter to the Administrator...

14 CFR 63.43 - Flight engineer courses.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Flight engineer courses. 63.43 Section 63...) AIRMEN CERTIFICATION: FLIGHT CREWMEMBERS OTHER THAN PILOTS Flight Engineers § 63.43 Flight engineer courses. An applicant for approval of a flight engineer course must submit a letter to the Administrator...

14 CFR 63.43 - Flight engineer courses.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Flight engineer courses. 63.43 Section 63...) AIRMEN CERTIFICATION: FLIGHT CREWMEMBERS OTHER THAN PILOTS Flight Engineers § 63.43 Flight engineer courses. An applicant for approval of a flight engineer course must submit a letter to the Administrator...

14 CFR 63.43 - Flight engineer courses.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Flight engineer courses. 63.43 Section 63...) AIRMEN CERTIFICATION: FLIGHT CREWMEMBERS OTHER THAN PILOTS Flight Engineers § 63.43 Flight engineer courses. An applicant for approval of a flight engineer course must submit a letter to the Administrator...

Development and testing of a mouse simulated space flight model

NASA Technical Reports Server (NTRS)

Sonnenfeld, Gerald

1987-01-01

The development and testing of a mouse model for simulating some aspects of weightlessness that occurs during space flight, and the carrying out of immunological experiments on animals undergoing space flight is examined. The mouse model developed was an antiorthostatic, hypokinetic, hypodynamic suspension model similar to one used with rats. The study was divided into two parts. The first involved determination of which immunological parameters should be observed on animals flown during space flight or studied in the suspension model. The second involved suspending mice and determining which of those immunological parameters were altered by the suspension. Rats that were actually flown in Space Shuttle SL-3 were used to test the hypotheses.

Space Flight Calcium: Implications for Astronaut Health, Spacecraft Operations, and Earth

PubMed Central

Smith, Scott M.; McCoy, Torin; Gazda, Daniel; Morgan, Jennifer L. L.; Heer, Martina; Zwart, Sara R.

2012-01-01

The space flight environment is known to induce bone loss and, subsequently, calcium loss. The longer the mission, generally the more bone and calcium are lost. This review provides a history of bone and calcium studies related to space flight and highlights issues related to calcium excretion that the space program must consider so that urine can be recycled. It also discusses a novel technique using natural stable isotopes of calcium that will be helpful in the future to determine calcium and bone balance during space flight. PMID:23250146

The nutritional status of astronauts is altered after long-term space flight aboard the International Space Station

NASA Technical Reports Server (NTRS)

Smith, Scott M.; Zwart, Sara R.; Block, Gladys; Rice, Barbara L.; Davis-Street, Janis E.

2005-01-01

Defining optimal nutrient requirements is critical for ensuring crew health during long-duration space exploration missions. Data pertaining to such nutrient requirements are extremely limited. The primary goal of this study was to better understand nutritional changes that occur during long-duration space flight. We examined body composition, bone metabolism, hematology, general blood chemistry, and blood levels of selected vitamins and minerals in 11 astronauts before and after long-duration (128-195 d) space flight aboard the International Space Station. Dietary intake and limited biochemical measures were assessed during flight. Crew members consumed a mean of 80% of their recommended energy intake, and on landing day their body weight was less (P = 0.051) than before flight. Hematocrit, serum iron, ferritin saturation, and transferrin were decreased and serum ferritin was increased after flight (P < 0.05). The finding that other acute-phase proteins were unchanged after flight suggests that the changes in iron metabolism are not likely to be solely a result of an inflammatory response. Urinary 8-hydroxy-2'-deoxyguanosine concentration was greater and RBC superoxide dismutase was less after flight (P < 0.05), indicating increased oxidative damage. Despite vitamin D supplement use during flight, serum 25-hydroxycholecalciferol was decreased after flight (P < 0.01). Bone resorption was increased after flight, as indicated by several markers. Bone formation, assessed by several markers, did not consistently rise 1 d after landing. These data provide evidence that bone loss, compromised vitamin D status, and oxidative damage are among critical nutritional concerns for long-duration space travelers.

Implications of Responsive Space on the Flight Software Architecture

NASA Technical Reports Server (NTRS)

Wilmot, Jonathan

2006-01-01

The Responsive Space initiative has several implications for flight software that need to be addressed not only within the run-time element, but the development infrastructure and software life-cycle process elements as well. The runtime element must at a minimum support Plug & Play, while the development and process elements need to incorporate methods to quickly generate the needed documentation, code, tests, and all of the artifacts required of flight quality software. Very rapid response times go even further, and imply little or no new software development, requiring instead, using only predeveloped and certified software modules that can be integrated and tested through automated methods. These elements have typically been addressed individually with significant benefits, but it is when they are combined that they can have the greatest impact to Responsive Space. The Flight Software Branch at NASA's Goddard Space Flight Center has been developing the runtime, infrastructure and process elements needed for rapid integration with the Core Flight software System (CFS) architecture. The CFS architecture consists of three main components; the core Flight Executive (cFE), the component catalog, and the Integrated Development Environment (DE). This paper will discuss the design of the components, how they facilitate rapid integration, and lessons learned as the architecture is utilized for an upcoming spacecraft.

Space Science Research and Technology at NASA's Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Johnson, Charles L.

2007-01-01

This presentation will summarize the various projects and programs managed in the Space Science Programs and Projects Office at NASA's Marshall Space Flight Center in Huntsville, Alabama. Projects in the portfolio include NASA's Chandra X-Ray telescope, Hinode solar physics satellite, various advanced space propulsion technologies, including solar sails and tethers, as well as NASA's Discovery and New Frontiers Programs.

T2 vertebral bone marrow changes after space flight

NASA Technical Reports Server (NTRS)

LeBlanc, A.; Lin, C.; Evans, H.; Shackelford, L.; Martin, C.; Hedrick, T.

1999-01-01

Bone biopsies indicate that during immobilization bone marrow adipose tissue increases while the functional cellular fraction decreases. One objective of our Spacelab flight experiment was to determine, using in vivo volume-localized magnetic resonance spectroscopy (VLMRS), whether bone marrow composition was altered by space flight. Four crew members of a 17 day Spacelab mission participated in the experiment. The apparent cellular fraction and transverse relaxation time (T2) were determined twice before launch and at several times after flight. Immediately after flight, no significant change in the cellular fraction was found. However, the T2 of the cellular, but not the fat component increased following flight, although to a variable extent, in all crew members with a time course for return to baseline lasting several months. The T2 of seven control subjects showed no significant change. Although these observations may have several explanations, it is speculated that the observed T2 changes might reflect increased marrow osteoblastic activity during recovery from space flight.

The NASA Human Space Flight Supply Chain, Current and Future

NASA Technical Reports Server (NTRS)

Zapata, Edgar

2007-01-01

The current NASA Human Space Flight transportation system, the Space Shuttle, is scheduled for final flight in 2010. The Exploration initiative will create a new capability with a combination of existing systems and new flight and ground elements. To fully understand and act on the implications of such change it is necessary to understand what, how, when and where such changes occur and more importantly, how all these interact. This paper presents Human Space Flight, with an emphasis on KSC Launch and Landing, as a Supply Chain of both information and materials. A supply chain methodology for understanding the flow of information and materials is presented. Further, modeling and simulation projects funded by the Exploration initiative to understand the NASA Exploration Supply Chain are explained. Key concepts and their purpose, including the Enterprise, Locations, Physical and Organizational Functional Units, Products, and Resources, are explained. It is shown that the art, science and perspective of Supply Chain Management is not only applicable to such a government & contractor operation, it is also an invaluable approach for understanding, focusing improvement and growth. It is shown that such commercial practice applies to Human Space Flight and is invaluable towards one day creating routine, affordable access to and from space.

Rehabilitation After International Space Station Flights

NASA Technical Reports Server (NTRS)

Chauvin, S. J.; Shepherd, B. A. S.; Guilliams, M. E.; Taddeo, T.

2003-01-01

Rehabilitating U.S. crew members to preflight status following flights on the Russian Mir Space Station required longer than six months for full functional recovery of some of the seven crew members. Additional exercise hardware has been added on the International Space Station as well as a rehabilitative emphasis on functional fitness/agility and proprioception. The authors will describe and present the results of the rehabilitation program for ISS and evaluate rehabilitative needs for longer missions. Pre- and in-flight programs emphasize strength and aerobic conditioning. One year before launch, crew members are assigned an Astronaut Strength and Conditioning specialist. Crew members are scheduled for 2 hours, 3 days a week, for pre-flight training and 2.5 hours, six days a week, for in-flight training. Crewmembers are tested on functional fitness, agility, isokinetic strength, and submaximal cycle ergometer evaluation before and after flight. The information from these tests is used for exercise prescriptions, comparison, and evaluation of the astronaut and training programs. The rehabilitation program lasts for 45 days and is scheduled for 2 hours during each crew workday. Phase 1 of the rehabilitation program starts on landing day and places emphasis on ambulation, flexibility, and muscle strengthening. Phase 2 adds proprioceptive exercise and cardiovascular conditioning. Phase 3 (the longest phase) focuses on functional development. All programs are tailored specifically for each individual according to their test results, preferred recreational activities, and mission roles and duties. Most crew members reached or exceeded their preflight test values 45 days after flight. Some crew members subjectively indicated the need for a longer rehabilitation period. The current rehabilitation program for returning ISS crew members seems adequate in content but may need to be extended for longer expeditions.

Apollo experience report: Flight planning for manned space operations

NASA Technical Reports Server (NTRS)

Oneill, J. W.; Cotter, J. B.; Holloway, T. W.

1972-01-01

The history of flight planning for manned space missions is outlined, and descriptions and examples of the various evolutionary phases of flight data documents from Project Mercury to the Apollo Program are included. Emphasis is given to the Apollo flight plan. Time line format and content are discussed in relationship to the manner in which they are affected by the types of flight plans and various constraints.

Operational Models Supporting Manned Space Flight

NASA Astrophysics Data System (ADS)

Johnson, A. S.; Weyland, M. D.; Lin, T. C.; Zapp, E. N.

2006-12-01

The Space Radiation Analysis Group (SRAG) at Johnson Space Center (JSC) has the primary responsibility to provide real-time radiation health operational support for manned space flight. Forecasts from NOAA SEC, real-time space environment data and radiation models are used to infer changes in the radiation environment due to space weather. Unlike current operations in low earth orbit which are afforded substantial protection from the geomagnetic field, exploration missions will have little protection and require improved operational tools for mission support. The current state of operational models and their limitations will be presented as well as an examination of needed tools to support exploration missions.

Flight simulator with spaced visuals

NASA Technical Reports Server (NTRS)

Gilson, Richard D. (Inventor); Thurston, Marlin O. (Inventor); Olson, Karl W. (Inventor); Ventola, Ronald W. (Inventor)

1980-01-01

A flight simulator arrangement wherein a conventional, movable base flight trainer is combined with a visual cue display surface spaced a predetermined distance from an eye position within the trainer. Thus, three degrees of motive freedom (roll, pitch and crab) are provided for a visual proprioceptive, and vestibular cue system by the trainer while the remaining geometric visual cue image alterations are developed by a video system. A geometric approach to computing runway image eliminates a need to electronically compute trigonometric functions, while utilization of a line generator and designated vanishing point at the video system raster permits facile development of the images of the longitudinal edges of the runway.

SpaceX Falcon Heavy Demo Flight - Ready for Launch

NASA Image and Video Library

2018-02-06

A SpaceX Falcon Heavy stands at Launch Complex 39A, far right, at NASA's Kennedy Space Center in Florida awaiting liftoff on its demonstration flight. In the foreground is the center’s iconic Vehicle Assembly Building. The demonstration flight is a significant milestone for the world's premier multi-user spaceport. In 2014, NASA signed a property agreement with SpaceX for the use and operation of the center's pad 39A, where the company has launched Falcon 9 rockets and is preparing for the first Falcon Heavy. NASA also has Space Act Agreements in place with partners, such as SpaceX, to provide services needed to process and launch rockets and spacecraft.

Biochemical and hematologic changes after short-term space flight

NASA Technical Reports Server (NTRS)

Leach, C. S.

1992-01-01

Clinical laboratory data from blood samples obtained from astronauts before and after 28 flights (average duration = 6 days) of the Space Shuttle were analyzed by the paired t-test and the Wilcoxon signed-rank test and compared with data from the Skylab flights (duration approximately 28, 59, and 84 days). Angiotensin I and aldosterone were elevated immediately after short-term space flights, but the response of angiotensin I was delayed after Skylab flights. Serum calcium was not elevated after Shuttle flights, but magnesium and uric acid decreased after both Shuttle and Skylab. Creatine phosphokinase in serum was reduced after Shuttle but not Skylab flights, probably because exercises to prevent deconditioning were not performed on the Shuttle. Total cholesterol was unchanged after Shuttle flights, but low density lipoprotein cholesterol increased and high density lipoprotein cholesterol decreased. The concentration of red blood cells was elevated after Shuttle flights and reduced after Skylab flights. Reticulocyte count was decreased after both short- and long-term flights, indicating that a reduction in red blood cell mass is probably more closely related to suppression of red cell production than to an increase in destruction of erythrocytes. Serum ferritin and number of platelets were also elevated after Shuttle flights. In determining the reasons for postflight differences between the shorter and longer flights, it is important to consider not only duration but also countermeasures, differences between spacecraft, and procedures for landing and egress.

Renal Stone Risk During Space Flight

NASA Technical Reports Server (NTRS)

Whitson, Peggy A.; Pietrzyk, Robert A.; Sams, Clarence F.; Pak, Charles Y. C.; Jones, Jeffrey A.

1999-01-01

Space flight produces a number of metabolic and physiological changes in the crewmembers exposed to microgravity. Following launch, body fluid volumes, electrolyte levels, and bone and muscle undergo changes as the human body adapts to the weightless environment. Changes in the urinary chemical composition may lead to the potentially serious consequences of renal stone formation. Previous data collected immediately after space flight indicate changes in the urine chemistry favoring an increased risk of calcium oxalate and uric acid stone formation (n = 323). During short term Shuttle space flights, the changes observed include increased urinary calcium and decreased urine volume, pH and citrate resulting in a greater risk for calcium oxalate and brushite stone formation (n = 6). Results from long duration Shuttle/Mir missions (n = 9) followed a similar trend and demonstrated decreased fluid intake and urine volume and increased urinary calcium resulting in a urinary environment saturated with the calcium stone-forming salts. The increased risk occurs rapidly upon exposure to microgravity, continues throughout the space flight and following landing. Dietary factors, especially fluid intake, or pharmacologic intervention can significantly influence the urinary chemical composition. Increasing fluid intake to produce a daily urine output of 2 liters/day may allow the excess salts in the urine to remain in solution, crystals formation will not occur and a renal stone will not develop. Results from long duration crewmembers (n = 2) who had urine volumes greater than 2.5 L/day minimized their risk of renal stone formation. Also, comparisons of stone-forming risk in short duration crewmembers clearly identified greater risk in those who produced less than 2 liters of urine/day. However, hydration and increased urine output does not correct the underlying calcium excretion due to bone loss and only treats the symptoms and not the cause of the increased urinary salts

R and T report: Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Soffen, Gerald A. (Editor)

1993-01-01

The 1993 Research and Technology Report for Goddard Space Flight Center is presented. Research covered areas such as (1) flight projects; (2) space sciences including cosmology, high energy, stars and galaxies, and the solar system; (3) earth sciences including process modeling, hydrology/cryology, atmospheres, biosphere, and solid earth; (4) networks, planning, and information systems including support for mission operations, data distribution, advanced software and systems engineering, and planning/scheduling; and (5) engineering and materials including spacecraft systems, material and testing, optics and photonics and robotics.

Overview of Additive Manufacturing Initiatives at NASA Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Clinton, R. G., Jr.

2018-01-01

NASA's In Space Manufacturing Initiative (ISM) includes: The case for ISM - why; ISM path to exploration - results from the 3D Printing In Zero-G Technology Demonstration - ISM challenges; In space Robotic Manufacturing and Assembly (IRMA); Additive construction. Additively Manufacturing (AM) development for liquid rocket engine space flight hardware. MSFC standard and specification for additively manufactured space flight hardware. Summary.

14 CFR 121.408 - Training equipment other than flight simulation training devices.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Training equipment other than flight simulation training devices. 121.408 Section 121.408 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 121.408 Training equipment other than flight simulation training devices. (a) The Administrator must...

Gene Kranz Visits Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

2006-01-01

On October 19, 2006, former NASA director of Mission Operations Gene Kranz was a keynote speaker at the Marshall Space Flight Center's (MSFC's) 2006 Annual Safety Day program. The best selling author of 'Failure Is Not An Option' and past Apollo flight director was featured during a morning session called 'Coffee and Kranz'. Marshall employees hung on his every word as he told the fascinating story of Apollo 13. Kranz was the acting flight director during the Apollo 13 mission, a mission that seemed doomed to fail due to an onboard explosion. Kranz and his flight control team worked around the clock relentlessly, solving problem after problem, until the crew was returned safely to Earth.

STS-132 ascent flight control team photo with Flight Director Richard Jones and the STS-132 crew

NASA Image and Video Library

2010-06-08

JSC2010-E-090665 (8 June 2010) --- The members of the STS-132 Ascent flight control team and crew members pose for a group portrait in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Richard Jones (right) and NASA astronaut Ken Ham, STS-132 commander, hold the STS-132 mission logo. Additional crew members pictured are NASA astronauts Tony Antonelli, pilot; along with Garrett Reisman, Piers Sellers, Michael Good and Steve Bowen, all mission specialists. Photo credit: NASA or National Aeronautics and Space Administration

Evaluation of NASA Foodbars as a standard diet for use in short-term rodent space flight studies.

PubMed

Tou, Janet; Grindeland, Richard; Barrett, Joyce; Dalton, Bonnie; Mandel, Adrian; Wade, Charles

2003-01-01

[corrected] A standard rodent diet for space flight must meet the unique conditions imposed by the space environment and must be nutritionally adequate because diet can influence the outcome of experiments. We evaluated the use of National Aeronautics and Space Administration (NASA) Foodbars as a standard space flight diet for rats. The Foodbar's semi-purified formulation permitted criteria such as nutrient consistency, high nutrient bioavailability, and flexibility of formulation to be met. Extrusion of the semi-purified diet produced Foodbars with the proper texture and a non-crumbing solid form for use in space. Treatment of Foodbar with 0.1% potassium sorbate prevented mold growth. Irradiation (15 to 25 kGy) prevented bacterial growth and, in combination with sorbate treatment, added protection against mold for shelf stability. During the development process, nutrient analyses indicated that extrusion and irradiation produces nutrient losses. Nutrients were adjusted accordingly to compensate for processing losses. Nutrient analysis of Foodbars continues to be performed routinely to monitor nutrient levels. It is important that the standard rodent diet provide nutrients that will prevent deficiency but also avoid excess that may mask physiologic changes produced by space flight. All vitamin levels in the Foodbars, except for vitamin K, conformed to or exceeded the current National Research Council (NRC) 1995 recommendations. All indispensable amino acids in Foodbar conformed to or exceeded the NRC nutrient recommendation for mouse growth and rat maintenance. However, some indispensable amino acids were slightly below recommendations for rat reproduction and growth. Short-term (18 to 20 d) animal feeding studies indicated that Foodbars are palatable, support growth, and maintain health in rats. Results indicated that NASA Rodent Foodbars meet the physical and nutritional criteria required to support rodents in the space environment and thus may be used

Evaluation of NASA Foodbars as a Standard Diet for Use in Short-Term Rodent Space Flight Studies

NASA Technical Reports Server (NTRS)

Tou, Janet; Grindeland, Richard; Barrett, Joyce; Dalton, Bonnie; Mandel, Adrian; Wade, Charles

2003-01-01

A standard rodent diet for space flight must meet the unique conditions imposed by the space environment and must be nutritionally adequate since diet can influence the outcome of experiments. This paper evaluates the use of National Aeronautics and Space Administration (NASA) developed Foodbars as a standard space flight diet for rats. The Foodbar's semi-purified formulation permits criteria such as nutrient consistency, high nutrient bioavailability and flexibility of formulation to be met. Extrusion of the semi-purified diet produces Foodbars with the proper texture and a non-crumbing solid form for use in space. Treatment of Foodbar with 0.1% potassium sorbate prevents mold growth. Irradiation (15-25 kGy) prevents bacterial growth and in combination with sorbate-treatment provides added protection against mold for shelf-stability. However, during the development process, nutrient analyses indicated that extrusion and irradiation produced nutrient losses. Nutrients were adjusted accordingly to compensate for processing losses. Nutrient analysis of Foodbars continues to be performed routinely to monitor nutrient levels. It is important that the standard rodent diet provide nutrients that will prevent deficiency but also avoid excess that may mask physiological changes produced by space flight. All vitamins levels in the Foodbars, except for vitamin K conformed to or exceeded the current NRC (1995) recommendations. All indispensable amino acids in Foodbar conformed to or exceeded the NRC nutrient recommendation for mice growth and rat maintenance. However, some indispensable amino acids were slightly below recommendations for rat reproduction/growth. Short-term (18-20 d) animal feeding studies indicated that Foodbars were palatable, supported growth and maintained health in rats. Results indicated that NASA rodent Foodbars meet both the physical and nutritional criteria required to support rodents in the space environment and thus, may be used successfully as a

Visual suppression of the vestibulo-ocular reflex during space flight

NASA Technical Reports Server (NTRS)

Uri, John J.; Thornton, William E.; Moore, Thomas P.; Pool, Sam L.

1989-01-01

Visual suppression of the vestibulo-ocular reflex was studied in 16 subjects on 4 Space Shuttle missions. Eye movements were recorded by electro-oculography while subjects fixated a head mounted target during active sinusoidal head oscillation at 0.3 Hz. Adequacy of suppression was evaluated by the number of nystagmus beats, the mean amplitude of each beat, and the cumulative amplitude of nystagmus during two head oscillation cycles. Vestibulo-ocular reflex suppression was unaffected by space flight. Subjects with space motion sickness during flight had significantly more nystagmus beats than unaffected individuals. These susceptible subjects also tended to have more nystagmus beats before flight.

Long-duration space flight and bed rest effects on testosterone and other steroids.

PubMed

Smith, Scott M; Heer, Martina; Wang, Zuwei; Huntoon, Carolyn L; Zwart, Sara R

2012-01-01

Limited data suggest that testosterone is decreased during space flight, which could contribute to bone and muscle loss. The main objective was to assess testosterone and hormone status in long- and short-duration space flight and bed rest environments and to determine relationships with other physiological systems, including bone and muscle. Blood and urine samples were collected before, during, and after long-duration space flight. Samples were also collected before and after 12- to 14-d missions and from participants in 30- to 90-d bed rest studies. Space flight studies were conducted on the International Space Station and before and after Space Shuttle missions. Bed rest studies were conducted in a clinical research center setting. Data from Skylab missions are also presented. All of the participants were male, and they included 15 long-duration and nine short-duration mission crew members and 30 bed rest subjects. Serum total, free, and bioavailable testosterone were measured along with serum and urinary cortisol, serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and SHBG. Total, free, and bioavailable testosterone was not changed during long-duration space flight but were decreased (P < 0.01) on landing day after these flights and after short-duration space flight. There were no changes in other hormones measured. Testosterone concentrations dropped before and soon after bed rest, but bed rest itself had no effect on testosterone. There was no evidence for decrements in testosterone during long-duration space flight or bed rest.

[From the flight of Iu. A. Gagarin to the contemporary piloted space flights and exploration missions].

PubMed

Grigor'ev, A I; Potapov, A N

2011-01-01

The first human flight to space made by Yu. A. Gagarin on April 12, 1961 was a crucial event in the history of cosmonautics that had a tremendous effect on further progress of the human civilization. Gagarin's flight had been prefaced by long and purposeful biomedical researches with the use of diverse bio-objects flown aboard rockets and artificial satellites. Data of these researches drove to the conclusion on the possibility in principle for humans to fly to space. After a series of early flights and improvements in the medical support system space missions to the Salyut and Mir station gradually extended to record durations. The foundations of this extension were laid by systemic researches in the fields of space biomedicine and allied sciences. The current ISS system of crew medical care has been successful in maintaining health and performance of cosmonauts as well as in providing the conditions for implementation of flight duties and operations with a broad variety of payloads. The ISS abounds in opportunities of realistic trial of concepts and technologies in preparation for crewed exploration missions. At the same, ground-based simulation of a mission to Mars is a venue for realization of scientific and technological experiments in space biomedicine.

14 CFR 25.1531 - Maneuvering flight load factors.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Maneuvering flight load factors. 25.1531 Section 25.1531 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Operating Limitations § 25.1531 Maneuvering flight load factors. Load factor limitations, not exceeding the...

14 CFR 25.1531 - Maneuvering flight load factors.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Maneuvering flight load factors. 25.1531 Section 25.1531 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Operating Limitations § 25.1531 Maneuvering flight load factors. Load factor limitations, not exceeding the...

NASA Aerosciences Activities to Support Human Space Flight

NASA Technical Reports Server (NTRS)

LeBeau, Gerald J.

2011-01-01

The Lyndon B. Johnson Space Center (JSC) has been a critical element of the United State's human space flight program for over 50 years. It is the home to NASA s Mission Control Center, the astronaut corps, and many major programs and projects including the Space Shuttle Program, International Space Station Program, and the Orion Project. As part of JSC's Engineering Directorate, the Applied Aeroscience and Computational Fluid Dynamics Branch is charted to provide aerosciences support to all human spacecraft designs and missions for all phases of flight, including ascent, exo-atmospheric, and entry. The presentation will review past and current aeroscience applications and how NASA works to apply a balanced philosophy that leverages ground testing, computational modeling and simulation, and flight testing, to develop and validate related products. The speaker will address associated aspects of aerodynamics, aerothermodynamics, rarefied gas dynamics, and decelerator systems, involving both spacecraft vehicle design and analysis, and operational mission support. From these examples some of NASA leading aerosciences challenges will be identified. These challenges will be used to provide foundational motivation for the development of specific advanced modeling and simulation capabilities, and will also be used to highlight how development activities are increasing becoming more aligned with flight projects. NASA s efforts to apply principles of innovation and inclusion towards improving its ability to support the myriad of vehicle design and operational challenges will also be briefly reviewed.

14 CFR 121.657 - Flight altitude rules.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight altitude rules. 121.657 Section 121... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Dispatching and Flight Release Rules § 121.657 Flight... other flight conditions, the Administrator prescribes other minimums for any route or part of a route...

14 CFR 121.657 - Flight altitude rules.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight altitude rules. 121.657 Section 121... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Dispatching and Flight Release Rules § 121.657 Flight... other flight conditions, the Administrator prescribes other minimums for any route or part of a route...

14 CFR 121.657 - Flight altitude rules.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight altitude rules. 121.657 Section 121... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Dispatching and Flight Release Rules § 121.657 Flight... other flight conditions, the Administrator prescribes other minimums for any route or part of a route...

14 CFR 121.657 - Flight altitude rules.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight altitude rules. 121.657 Section 121... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Dispatching and Flight Release Rules § 121.657 Flight... other flight conditions, the Administrator prescribes other minimums for any route or part of a route...

Current Activities and Capabilities of the Terrestrial Environment Group at NASA's Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Roberts, Barry C.; Batts, Wade

1997-01-01

The National Aeronautics and Space Administration (NASA) designated Marshall Space Flight Center (MSFC) the center of excellence for space transportation. The Aerospace Environments and Effects (AEE) team of the Electromagnetics and Aerospace Environments Branch (EL23) in the Systems Analysis and Integration Laboratory at MSFC, supports the center of excellence designation by providing near-Earth space, deep space, planetary, and terrestrial environments expertise to projects as required. The Terrestrial Environment (TE) group within the AEE team maintains an extensive TE data base. Statistics and models derived from this data are applied to the design and development of new aerospace vehicles, as well as performance enhancement of operational vehicles such as the Space Shuttle. The TE is defined as the Earth's atmospheric environment extending from the surface to orbital insertion altitudes (approximately 90 km).

Photonic Component Qualification and Implementation Activities at NASA Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Ott, Melanie N.; Jin, Xiaodan Linda; Chuska, Richard F.; LaRocca, Frank V.; MacMurphy, Shawn L.; Matuszeski, Adam J.; Zellar, Ronald S.; Friedberg, Patricia R.; Malenab, Mary C.

2006-01-01

The photonics group in Code 562 at NASA Goddard Space Flight Center supports a variety of space flight programs at NASA including the: International Space Station (ISS), Shuttle Return to Flight Mission, Lunar Reconnaissance Orbiter (LRO), Express Logistics Carrier, and the NASA Electronic Parts and Packaging Program (NEPP). Through research, development, and testing of the photonic systems to support these missions much information has been gathered on practical implementations for space environments. Presented here are the highlights and lessons learned as a result of striving to satisfy the project requirements for high performance and reliable commercial optical fiber components for space flight systems. The approach of how to qualify optical fiber components for harsh environmental conditions, the physics of failure and development lessons learned will be discussed.

Jump-Down Performance Alterations after Space Flight

NASA Technical Reports Server (NTRS)

Reschke, M. F.; Kofman, I. S.; Cerisano, J. M.; Fisher, E. A.; Peters, B. T.; Miller, C. A.; Harm, D. L.; Bloomberg, J. J.

2011-01-01

INTRODUCTION: Successful jump performance requires functional coordination of visual, vestibular, and somatosensory systems, which are affected by prolonged exposure to microgravity. Astronauts returning from space flight exhibit impaired ability to coordinate effective landing strategies when jumping from a platform to the ground. This study compares jump strategies used by astronauts before and after flight, changes to those strategies within a test session, and recoveries in jump-down performance parameters across several postflight test sessions. These data were obtained as part of an ongoing interdisciplinary study (Functional Task Test, FTT) designed to evaluate both astronaut postflight functional performance and related physiological changes. METHODS: Seven astronauts from short-duration (Shuttle) and three from long-duration (International Space Station) flights performed 3 two-footed jumps from a platform 30 cm high onto a force plate that measured the ground reaction forces and center-of-pressure displacement from the landings. Neuromuscular activation data were collected from the medial gastrocnemius and anterior tibialis of both legs using surface electromyography electrodes. Two load cells in the platform measured the load exerted by each foot during the takeoff phase of the jump. Data were collected in 2 preflight sessions, on landing day (Shuttle only), and 1, 6, and 30 days after flight. RESULTS: Postural settling time was significantly increased on the first postflight test session and many of the astronauts tested were unable to maintain balance on their first jump landing but recovered by the third jump, showing a learning progression in which performance improvements could be attributed to adjustments in takeoff or landing strategy. Jump strategy changes were evident in reduced air time (time between takeoff and landing) and also in increased asymmetry in foot latencies on takeoff. CONCLUSIONS: The test results revealed significant decrements

Space industrialization. [space flight and environment for commercial/utilitarian purposes

NASA Technical Reports Server (NTRS)

Disher, J. H.

1977-01-01

Space industrialization is defined as the use of space flight and the space environment for commercial or utilitarian purposes in contrast to other uses such as gains in basic scientific knowledge, national defense, or exploration. Some unique attributes of space that make it amenable to industrial use include overview of the earth, the 'zero gravity' effect, potential for near perfect vacuum, unlimited reservoir for disposal of waste products, availability of essentially uninterrupted flow of solar energy, and the 'perpetual motion' characteristic of orbital mechanics. The role of human participation in assembling and maintaining the large sophisticated systems that will be required for future space industrialization needs is considered.

[Protein turnover during and after extended space flight

NASA Technical Reports Server (NTRS)

Stein, T. P.; Larina, I. M.; Leskiv, M. J.; Schluter, M. D.

2000-01-01

A 15N-glycine tracer technique was used to study protein turnover in four Russian cosmonauts and two U.S. astronauts who had spent long time aboard the Russian orbital station MIR. As was shown, in space flight protein synthesis falls by 46% on the average, which substantially exceeds estimations made on the basis of data about bed-rested human subjects. Reduction in protein synthesis during space flight is connected with the negative energy balance; therefore, it appears imperative to keep balance between energy intake (foodstuffs) and expenditure by cosmonauts on long-term mission.

14 CFR 121.515 - Flight time limitations: All airmen: airplanes.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight time limitations: All airmen: airplanes. 121.515 Section 121.515 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Operations § 121.515 Flight time limitations: All airmen: airplanes. No airman may be aloft as a flight...

14 CFR 121.515 - Flight time limitations: All airmen: airplanes.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight time limitations: All airmen: airplanes. 121.515 Section 121.515 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Operations § 121.515 Flight time limitations: All airmen: airplanes. No airman may be aloft as a flight...

14 CFR 121.515 - Flight time limitations: All airmen: airplanes.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight time limitations: All airmen: airplanes. 121.515 Section 121.515 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Operations § 121.515 Flight time limitations: All airmen: airplanes. No airman may be aloft as a flight...

14 CFR 121.515 - Flight time limitations: All airmen: airplanes.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight time limitations: All airmen: airplanes. 121.515 Section 121.515 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Operations § 121.515 Flight time limitations: All airmen: airplanes. No airman may be aloft as a flight...

14 CFR 121.515 - Flight time limitations: All airmen: airplanes.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight time limitations: All airmen: airplanes. 121.515 Section 121.515 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Operations § 121.515 Flight time limitations: All airmen: airplanes. No airman may be aloft as a flight...

Effects of space flight on GLUT-4 content in rat plantaris muscle

NASA Astrophysics Data System (ADS)

Tabata, I.; Kawanaka, Kentaro; Sekiguchi, Chiharu; Nagaoka, Shunji; Ohira, Yoshinobu

The effects of 14 days of space flight on the glucose transporter protein (GLUT-4) were studied in the plantaris muscle of growing 9-week-old, male Sprague Dawley rats. The rats were randomly separated into five groups: pre-flight vivarium ground controls (PF-VC) sacrificed approximately 2 h after launch; flight groups sacrificed either approximately 5 h (F-R0) or 9 days (F-R9) after the return from space; and synchronous ground controls (SC-R0 and SC-R9) sacrificed at the same time as the respective flight groups. The flight groups F-R0 and F-R9 were exposed to micro-gravity for 14 days in the Spacelab module located in the cargo bay of the shuttle transport system - 58 of the manned Space Shuttle for the NASA mission named ''Spacelab Life Sciences 2''. Body weight and plantaris weight of SC-R0 and F-R0 were significantly higher than those of PF-VC. Neither body weight nor plantaris muscle weight in either group had changed 9 days after the return from space. As a result, body weight and plantaris muscle weight did not differ between the flight and synchronous control groups at any of the time points investigated. The GLUT-4 content (cpm/µg membrane protein) in the plantaris muscle did not show any significant change in response to 14 days of space flight or 9 days after return. Similarly, citrate synthase activity did not change during the course of the space flight or the recovery period. These results suggest that 14 days of space flight does not affect muscle mass or GLUT-4 content of the fast-twitch plantaris muscle in the rat.

Force limits measured on a space shuttle flight

NASA Technical Reports Server (NTRS)

Scharton, T.

2000-01-01

The random vibration forces between a payload and the sidewall of the space shuttle have been measured in flight and compared with the force specifications used in ground vibration tests. The flight data are in agreement with a semi-empirical method, which is widely used to predict vibration test force limits.

14 CFR 133.41 - Flight characteristics requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight characteristics requirements. 133.41... EXTERNAL-LOAD OPERATIONS Airworthiness Requirements § 133.41 Flight characteristics requirements. (a) The applicant must demonstrate to the Administrator, by performing the operational flight checks prescribed in...

14 CFR 133.41 - Flight characteristics requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight characteristics requirements. 133.41... EXTERNAL-LOAD OPERATIONS Airworthiness Requirements § 133.41 Flight characteristics requirements. (a) The applicant must demonstrate to the Administrator, by performing the operational flight checks prescribed in...

14 CFR 133.41 - Flight characteristics requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight characteristics requirements. 133.41... EXTERNAL-LOAD OPERATIONS Airworthiness Requirements § 133.41 Flight characteristics requirements. (a) The applicant must demonstrate to the Administrator, by performing the operational flight checks prescribed in...

In-flight measurement of the National Oceanic and Atmospheric Administration (NOAA)-10 static Earth sensor error

NASA Technical Reports Server (NTRS)

Harvie, E.; Filla, O.; Baker, D.

1993-01-01

Analysis performed in the Goddard Space Flight Center (GSFC) Flight Dynamics Division (FDD) measures error in the static Earth sensor onboard the National Oceanic and Atmospheric Administration (NOAA)-10 spacecraft using flight data. Errors are computed as the difference between Earth sensor pitch and roll angle telemetry and reference pitch and roll attitude histories propagated by gyros. The flight data error determination illustrates the effect on horizon sensing of systemic variation in the Earth infrared (IR) horizon radiance with latitude and season, as well as the effect of anomalies in the global IR radiance. Results of the analysis provide a comparison between static Earth sensor flight performance and that of scanning Earth sensors studied previously in the GSFC/FDD. The results also provide a baseline for evaluating various models of the static Earth sensor. Representative days from the NOAA-10 mission indicate the extent of uniformity and consistency over time of the global IR horizon. A unique aspect of the NOAA-10 analysis is the correlation of flight data errors with independent radiometric measurements of stratospheric temperature. The determination of the NOAA-10 static Earth sensor error contributes to realistic performance expectations for missions to be equipped with similar sensors.

Physiology, medicine, long-duration space flight and the NSBRI

NASA Technical Reports Server (NTRS)

McPhee, J. C.; White, R. J.

2003-01-01

The hazards of long-duration space flight are real and unacceptable. In order for humans to participate effectively in long-duration orbital missions or continue the exploration of space, we must first secure the health of the astronaut and the success of such missions by assessing in detail the biomedical risks of space flight and developing countermeasures to these hazards. Acquiring the understanding necessary for building a sound foundation for countermeasure development requires an integrated approach to research in physiology and medicine and a level of cooperative action uncommon in the biomedical sciences. The research program of the National Space Biomedical Research Institute (NSBRI) was designed to accomplish just such an integrated research goal, ameliorating or eliminating the biomedical risks of long-duration space flight and enabling safe and productive exploration of space. The fruits of these labors are not limited to the space program. We can also use the gained understanding of the effects and mechanisms of the physiological changes engendered in space and the applied preventive and rehabilitative methods developed to combat these changes to the benefit of those on Earth who are facing similar physiological and psychological difficulties. This paper will discuss the innovative approach the NSBRI has taken to integrated research management and will present some of the successes of this approach. c2003 International Astronautical Federation. Published by Elsevier Science Ltd. All rights reserved.

Human Space Flight Plans Committee

NASA Image and Video Library

2009-08-11

Members of the Human Space Flight Review Committee from left, Jeffrey Greason, Dr. Christopher Chyba, Dr. Leroy Chiao, Dr. Sally Ride, Norman Augustine (chair), Philip McAllister, Dr. Edward Crawley, Dr. Wanda Austin, and Bhodan Bejmuk review their notes prior to the start of a public meeting, Wednesday, Aug. 12, 2009, in Washington. Photo Credit: (NASA/Paul E. Alers)

Long-Duration Space Flight and Bed Rest Effects on Testosterone and Other Steroids

PubMed Central

Heer, Martina; Wang, Zuwei; Huntoon, Carolyn L.; Zwart, Sara R.

2012-01-01

Context: Limited data suggest that testosterone is decreased during space flight, which could contribute to bone and muscle loss. Objective: The main objective was to assess testosterone and hormone status in long- and short-duration space flight and bed rest environments and to determine relationships with other physiological systems, including bone and muscle. Design: Blood and urine samples were collected before, during, and after long-duration space flight. Samples were also collected before and after 12- to 14-d missions and from participants in 30- to 90-d bed rest studies. Setting: Space flight studies were conducted on the International Space Station and before and after Space Shuttle missions. Bed rest studies were conducted in a clinical research center setting. Data from Skylab missions are also presented. Participants: All of the participants were male, and they included 15 long-duration and nine short-duration mission crew members and 30 bed rest subjects. Main Outcome Measures: Serum total, free, and bioavailable testosterone were measured along with serum and urinary cortisol, serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and SHBG. Results: Total, free, and bioavailable testosterone was not changed during long-duration space flight but were decreased (P < 0.01) on landing day after these flights and after short-duration space flight. There were no changes in other hormones measured. Testosterone concentrations dropped before and soon after bed rest, but bed rest itself had no effect on testosterone. Conclusions: There was no evidence for decrements in testosterone during long-duration space flight or bed rest. PMID:22049169

Vehicle Engineering Development Activities at the Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Fisher, Mark F.; Champion, Robert H., Jr.

1999-01-01

New initiatives in the Space Transportation Directorate at the Marshall Space Flight Center include an emphasis on Vehicle Engineering to enhance the strong commitment to the Directorate's projects in the development of flight hardware and flight demonstrators for the advancement of space transportation technology. This emphasis can be seen in the activities of a newly formed organization in the Transportation Directorate, The Vehicle Subsystems Engineering Group. The functions and type of activities that this group works on are described. The current projects of this group are outlined including a brief description of the status and type of work that the group is performing. A summary section is included to describe future activities.

Ambiguous Tilt and Translation Motion Cues after Space Flight and Otolith Assessment during Post-Flight Re-Adaptation

NASA Technical Reports Server (NTRS)

Wood, Scott J.; Clarke, A. H.; Harm, D. L.; Rupert, A. H.; Clement, G. R.

2009-01-01

Adaptive changes during space flight in how the brain integrates vestibular cues with other sensory information can lead to impaired movement coordination, vertigo, spatial disorientation and perceptual illusions following Gtransitions. These studies are designed to examine both the physiological basis and operational implications for disorientation and tilt-translation disturbances following short duration space flights.

Apollo experience report. Crew-support activities for experiments performed during manned space flight

NASA Technical Reports Server (NTRS)

Mckee, J. W.

1974-01-01

Experiments are performed during manned space flights in an attempt to acquire knowledge that can advance science and technology or that can be applied to operational techniques for future space flights. A description is given of the procedures that the personnel who are directly assigned to the function of crew support at the NASA Lyndon B. Johnson Space Center use to prepare for and to conduct experiments during space flight.

14 CFR 135.97 - Aircraft and facilities for recent flight experience.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Aircraft and facilities for recent flight experience. 135.97 Section 135.97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Flight Operations § 135.97 Aircraft and facilities for recent flight experience. Each certificate holder...

14 CFR 135.97 - Aircraft and facilities for recent flight experience.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Aircraft and facilities for recent flight experience. 135.97 Section 135.97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Flight Operations § 135.97 Aircraft and facilities for recent flight experience. Each certificate holder...

14 CFR 135.97 - Aircraft and facilities for recent flight experience.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Aircraft and facilities for recent flight experience. 135.97 Section 135.97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Flight Operations § 135.97 Aircraft and facilities for recent flight experience. Each certificate holder...

14 CFR 135.97 - Aircraft and facilities for recent flight experience.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Aircraft and facilities for recent flight experience. 135.97 Section 135.97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Flight Operations § 135.97 Aircraft and facilities for recent flight experience. Each certificate holder...

14 CFR 135.97 - Aircraft and facilities for recent flight experience.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Aircraft and facilities for recent flight experience. 135.97 Section 135.97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Flight Operations § 135.97 Aircraft and facilities for recent flight experience. Each certificate holder...

Red blood cell and iron metabolism during space flight

NASA Technical Reports Server (NTRS)

Smith, Scott M.

2002-01-01

Space flight anemia is a widely recognized phenomenon in astronauts. Reduction in circulating red blood cells and plasma volume results in a 10% to 15% decrement in circulatory volume. This effect appears to be a normal physiologic adaptation to weightlessness and results from the removal of newly released blood cells from the circulation. Iron availability increases, and (in the few subjects studied) iron stores increase during long-duration space flight. The consequences of these changes are not fully understood.

Space Station flight telerobotic servicer functional requirements development

NASA Technical Reports Server (NTRS)

Oberright, John; Mccain, Harry; Whitman, Ruth I.

1987-01-01

The Space Station flight telerobotic servicer (FTS), a flight robotic system for use on the first Space Station launch, is described. The objectives of the FTS program include: (1) the provision of an alternative crew EVA by supporting the crew in assembly, maintenance, and servicing activities, and (2) the improvement of crew safety by performing hazardous tasks such as spacecraft refueling or thermal and power system maintenance. The NASA/NBS Standard Reference Model provides the generic, hierarchical, structured functional control definition for the system. It is capable of accommodating additional degrees of machine intelligence in the future.

14 CFR 21.35 - Flight tests.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Flight tests. 21.35 Section 21.35... PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.35 Flight tests. (a) Each applicant for an aircraft...) That the aircraft conforms with the type design; and (4) That the Administrator received a flight test...

Men and Women in Space: Bone Loss and Kidney Stone Risk after Long-Duration Space Flight

NASA Technical Reports Server (NTRS)

Smith, Scott M.; Zwart, Sara R.; Heer, Martina; Hudson, Edgar, K.; Shackelford, Linda; Morgan, Jennifer L. L.

2014-01-01

Bone loss on Earth is more prevalent in women than men, leading to the assumption that women may be at greater risk from bone loss during flight. Until recently, the number of women having flown long-duration missions was too small to allow any type of statistical analysis. We report here data from 42 astronauts on long-duration missions to the International Space Station, 33 men and 9 women. Bone mineral density (dual-energy X-ray absorptiometry), bone biochemistry (from blood and urine samples), and renal stone risk factors were evaluated before and after flight. Data were analyzed in two groups, based on available resistance exercise equipment. The response of bone mineral density to flight was the same for men and women, and the typical decrease in bone mineral density (whole body and/or regional) after flight was not observed for either sex for those using an Advanced Resistive Exercise Device. Bone biochemistry, specifically markers of formation and resorption, generally responded similarly in male and female astronauts. The response of urinary supersaturation risk to space flight was not significantly different between men and women, although risks were typically increased after flight in both groups and risks were generally greater in men than in women before and after flight. Overall, the bone and renal stone responses of men and women to space flight were not different.

The Legacy of Space Shuttle Flight Software

NASA Technical Reports Server (NTRS)

Hickey, Christopher J.; Loveall, James B.; Orr, James K.; Klausman, Andrew L.

2011-01-01

The initial goals of the Space Shuttle Program required that the avionics and software systems blaze new trails in advancing avionics system technology. Many of the requirements placed on avionics and software were accomplished for the first time on this program. Examples include comprehensive digital fly-by-wire technology, use of a digital databus for flight critical functions, fail operational/fail safe requirements, complex automated redundancy management, and the use of a high-order software language for flight software development. In order to meet the operational and safety goals of the program, the Space Shuttle software had to be extremely high quality, reliable, robust, reconfigurable and maintainable. To achieve this, the software development team evolved a software process focused on continuous process improvement and defect elimination that consistently produced highly predictable and top quality results, providing software managers the confidence needed to sign each Certificate of Flight Readiness (COFR). This process, which has been appraised at Capability Maturity Model (CMM)/Capability Maturity Model Integration (CMMI) Level 5, has resulted in one of the lowest software defect rates in the industry. This paper will present an overview of the evolution of the Primary Avionics Software System (PASS) project and processes over thirty years, an argument for strong statistical control of software processes with examples, an overview of the success story for identifying and driving out errors before flight, a case study of the few significant software issues and how they were either identified before flight or slipped through the process onto a flight vehicle, and identification of the valuable lessons learned over the life of the project.

Human Space Flight Plans Committee

NASA Image and Video Library

2009-08-11

Members of the Human Space Flight Review Committee from left, Jeffrey Greason, Dr. Christopher Chyba, Dr. Leroy Chiao, Dr. Sally Ride, Norman Augustine (chair), Philip McAllister, Dr. Edward Crawley, Dr. Wanda Austin (not seen), and Bhodan Bejmuk review their notes prior to the start of a public meeting, Wednesday, Aug. 12, 2009, in Washington. Photo Credit: (NASA/Paul E. Alers)

Hindlimb unloading of growing rats: a model for predicting skeletal changes during space flight.

PubMed

Morey-Holton, E R; Globus, R K

1998-05-01

A model that uses hindlimb unloading of rats was developed to study the consequences of skeletal unloading and reloading as occurs during and following space flight. Studies using the model were initiated two decades ago and further developed at National Aeronautics and Space Administration (NASA)-Ames Research Center. The model mimics some aspects of exposure to microgravity by removing weightbearing loads from the hindquarters and producing a cephalic fluid shift. Unlike space flight, the forelimbs remain loaded in the model, providing a useful internal control to distinguish between the local and systemic effects of hindlimb unloading. Rats that are hindlimb unloaded by tail traction gain weight at the same rate as pairfed controls, and glucocorticoid levels are not different from controls, suggesting that systemic stress is minimal. Unloaded bones display reductions in cancellous osteoblast number, cancellous mineral apposition rate, trabecular bone volume, cortical periosteal mineralization rate, total bone mass, calcium content, and maturation of bone mineral relative to controls. Subsequent studies reveal that these changes also occur in rats exposed to space flight. In hindlimb unloaded rats, bone formation rates and masses of unloaded bones decline relative to controls, while loaded bones do not change despite a transient reduction in serum 1,25-dihydroxyvitamin D (1,25D) concentrations. Studies using the model to evaluate potential countermeasures show that 1,25D, growth hormone, dietary calcium, alendronate, and muscle stimulation modify, but do not completely correct, the suppression of bone growth caused by unloading, whereas continuous infusion of transforming growth factor-beta2 or insulin-like growth factor-1 appears to protect against some of the bone changes caused by unloading. These results emphasize the importance of local as opposed to systemic factors in the skeletal response to unloading, and reveal the pivotal role that osteoblasts play in