Building a Model System of Developmental Services in Orange County

ERIC Educational Resources Information Center

Halfon, Neal; Russ, Shirley; Regalado, Michael

2004-01-01

In 1998, California voters passed Proposition 10, the California Children and Families First Act, which provides for an excise tax on tobacco products to fund parent education, health and child care programs that promote early childhood development for 0-5s. Since the adoption of its first Strategic Plan (2000), the Orange County First 5…

Ground-Water Data in Orange County and Adjacent Counties, Texas, 1985-90

DTIC Science & Technology

1999-01-01

UJ–62–58–809 Owner: Orange County WCID 3, well 3 Screen: 570–650 feet Altitude: 7 feet Well UJ–62–58–810 Owner: P.J. Silkwood Screen: 160–170 feet...25.0 220 220 220 220 UJ–62–58–810 P.J. Silkwood 160–170 CHCTU 11–13–85 10–28–86 10–29–87 10–18–88 12–07–89 1,200 1,190 1,200 1,200 1,140 7.5

Orange County, Yellow History: An Intimate Encounter with Vietnamese American Lives

ERIC Educational Resources Information Center

Tranguyen, Trangdai

2004-01-01

Anchored on the Vietnamese American Project (VAP), this essay presents the documentation of the Vietnamese American Experience through the voices of ethnic Vietnamese in Orange County, California, home to the largest concentration of this ethnic group outside Vietnam. Groundbreaking in its approach and method, VAP is an open forum that enables…

Heavy metals in navel orange orchards of Xinfeng County and their transfer from soils to navel oranges.

PubMed

Cheng, Jinjin; Ding, Changfeng; Li, Xiaogang; Zhang, Taolin; Wang, Xingxiang

2015-12-01

This study investigated heavy metal concentrations in soils and navel oranges of Xinfeng County, a well-known navel orange producing area of China. The results showed that the average concentrations of lead (Pb), cadmium (Cd), chromium (Cr), arsenic (As) and mercury (Hg) in orchard soils all increased compared to the regional background values, especially for Cd, which increased by 422%. When compared to the Chinese Environmental Quality Standard for soil (GB15618-1995), Pb, Cr and Hg concentrations in all orchard soil samples were below the limit standards, but Cd concentrations in 24 soil samples (21%) and As concentrations in 8 soil samples (7%) exceeded the limit standards. However, concentrations of all heavy metals in navel orange pulps were within the National Food Safety Standard of China (GB 2762-2012). Dietary risk assessment also showed that the exposure to these five heavy metals by consumption of navel oranges could hardly pose adverse health effects on adults and children. Since the range and degree of soil Cd pollution was widest and the most severe of all, Cd was taken as an example to reveal the transfer characteristics of heavy metals in soil-navel orange system. Cd concentrations in different organs of navel orange trees decreased in the following order: root>leaf>peel>pulp. That navel oranges planted in the Cd contaminated soils were within the national food safety standard was mainly due to the low transfer factor for Cd from soil to pulp (TFpulp). Further studies showed that TFpulp was significantly negatively correlated with soil pH, organic carbon (OC) and cation exchange capacity (CEC). Based on these soil properties, a prediction equation for TFpulp was established, which indicated that the risk for Cd concentration of navel orange pulp exceeding the national food limit is generally low, when soil Cd concentration is below 7.30 mg/kg. If appropriate actions are taken to increase soil pH, OC and CEC, Cd concentrations in navel orange pulps

Career Education Pilot Project K-14. Orange County Consortium. Needs Assessment.

ERIC Educational Resources Information Center

Schrodi, Tom; And Others

Summarized are the outcomes of a needs assessment of the Career Education Pilot Project for grades K-14 conducted in the Orange County (California) Consortium. Interviews and questionnaires were used to obtain data from teachers, students, and parents on the target area as well as from 150 service agencies in the communities. Findings include: (1)…

Instantaneous network RTK in Orange County, California

NASA Astrophysics Data System (ADS)

Bock, Y.

2003-04-01

The Orange County Real Time GPS Network (OCRTN) is an upgrade of a sub-network of SCIGN sites in southern California to low latency (1-2 sec), high-rate (1 Hz) data streaming, analysis, and dissemination. The project is a collaborative effort of the California Spatial Reference Center (CSRC) and the Orange County Public Resource and Facilities Division, with partners from the geophysical community, local and state government, and the private sector. Currently, ten sites are streaming 1 Hz raw data (Ashtech binary MBEN format) by means of dedicated, point-to-point radio modems to a network hub that translates the asynchronous serial data to TCP/IP and onto a PC workstation residing on a local area network. Software residing on the PC allows multiple clients to access the raw data simultaneously though TCP/IP. One of the clients is a Geodetics RTD server that receives and archives (1) the raw 1 Hz network data, (2) estimates of instantaneous positions and zenith tropospheric delays for quality control and detection of ground motion, and (3) RINEX data to decimated to 30 seconds. Data recovery is typically 99-100%. The server also produces 1 Hz RTCM data (messages 18, 19, 3 and 22) that are available by means of TCP/IP to RTK clients with wireless Internet modems. Coverage is excellent throughout the county. The server supports standard RTK users and is compatible with existing GPS instrumentation. Typical latency is 1-2 s, with initialization times of several seconds to minutes OCRTN site spacing is 10-15 km. In addition, the server supports “smart clients” who can retrieve data from the closest n sites (typically 3) and obtain an instantaneous network RTK position with 1-2 s latency. This mode currently requires a PDA running the RTD client software, and a wireless card. Since there is no initialization and re-initialization required this approach is well suited to support high-precision (centimeter-level) dynamic applications such as intelligent transportation

Measles outbreak in an unvaccinated family and a possibly associated international traveler - Orange County, Florida, December 2012-January 2013.

PubMed

Slade, Tania A; Klekamp, Benjamin; Rico, Edhelene; Mejia-Echeverry, Alvaro

2014-09-12

The Florida Department of Health in Orange County (DOH-Orange) was notified by a child care facility on January 11, 2013, that a parent had reported that an attendee and three siblings were ill with measles. All four siblings were unvaccinated for measles and had no travel history outside of Orange County during the periods when they likely had been exposed. A fifth, possibly associated case was later reported in a Brazilian citizen who had become ill while vacationing in Florida. The outbreak investigation that was conducted at multiple community settings in Orange County, including at an Orlando-area theme park, identified no additional cases. The genotype sequence was identical for cases 2-5, and visits to the same theme park suggested an unknown, common exposure and link between the cases. Sources of measles exposure can be difficult to identify for every measles case. Measles should be considered in the differential diagnosis of febrile rash illness, especially in unvaccinated persons. Reporting a confirmed or suspected case immediately to public health authorities is critical to limit the spread of measles.

Community Perspectives on Cultural Considerations for Breast and Cervical Cancer Education among Marshallese Women in Orange County, California

PubMed Central

Briand, Greta; Peters, Ruth

2017-01-01

The Marshallese community of Orange County California is a part of a highly mobile population that migrates between Hawai‘i, Arkansas, Washington, and California. In Orange County, the Marshallese community is primarily centered on faith-based organization in the city of Costa Mesa. Culture and language strengthen the bonds between different Marshallese communities across the U.S., and churches serve as conduits for communication between groups. Culture also places an important role in guiding behavior pertaining to health and social interaction. For instance, as in many other cultures, Marshallese men and women do not speak to each other about health, particularly reproductive health, in an open social setting. In Orange County, one female Marshallese health educator promotes breast and cervical cancer screening by talking informally with women, usually in faith-based settings and in-home visits. This community commentary describes the key cultural considerations and strategies used by the health educator to reach and educate the community. PMID:29805327

Susceptibility of ground water to surface and shallow sources of contamination, Orange County, North Carolina

USGS Publications Warehouse

Terziotti, Silvia; Eimers, J.L.

1999-01-01

In 1998, the relative susceptibility of ground water in Orange County, North Carolina,to contamination from surface and shallow sources was evaluated. A geographic information system was used to build three county-wide layers--soil permeability, land use/land cover, and land-surface slope. The harmonic mean permeability of soil layers was used to estimate a location's capacity to transmit water through the soil. Values for each of these three factors were categorized and ranked from 1 to 10 according to relative potential for contamination. Each factor was weighted to reflect its relative potential contribution to ground-water contamination, then the factors were combined to create a relative susceptibility index. The relative susceptibility index was categorized to reflect lowest, low, moderate, high, and highest potential for ground-water contamination. The relative susceptibility index for about 12 percent of the area in Orange County was categorized as high or highest. The high and highest range areas have highly permeable soils, land cover or land-use activities that have a high contamination potential, and low to moderate slopes. Most of the county is within the moderate category of relative susceptibility to ground-water contamination. About 21 percent of the county is ranked as low or lowest relative susceptibility to ground-water contamination.

Ground-water recharge to the regolith-fractured crystalline rock aquifer system, Orange County, North Carolina

USGS Publications Warehouse

Daniel, C. C.

1996-01-01

Quantitative information concerning recharge rates to aquifers and ground water in storage is needed to manage the development of ground-water resources. The amount of ground water available from the regolith-fractured crystalline rock aquifer system in Orange County, North Carolina, is largely unknown. If historical patterns seen throughout the Piedmont continue into the future, the number of ground-water users in the county can be expected to increase. In order to determine the maximum population that can be supplied by ground water, planners and managers of suburban development must know the amount of ground water that can be withdrawn without exceeding recharge and(or) overdrafting water in long-term storage. Results of the study described in this report help provide this information. Estimates of seasonal and long-term recharge rates were estimated for 12 selected drainage basins and subbasins using streamflow data and an analytical technique known as hydrograph separation. Methods for determining the quality of ground water in storage also are described. Orange County covers approximately 401 square miles in the eastern part of the Piedmont Province. The population of the county in 1990 was about 93,850; approximately 41 percent of the population depends on ground water as a source of potable supplies. Ground water is obtained from wells tapping the regolith-fractured crystalline rock aquifer system that underlies most of the county. Ground water also is obtained from Triassic age sedimentary rocks that occur in a small area in southeastern Orange County. Under natural conditions, recharge to the county's ground-water system is derived from the infiltration of precipitation. Ground-water recharge from precipitation cannot be measured directly; however, an estimate of the amount of precipitation that infiltrates into the ground and ultimately reaches the streams of the region can be determined by the technique of hydrograph separation. Data from 17 gaging

78 FR 729 - Ellman Battery Superfund Site; Orlando, Orange County, FL; Notice of Settlement

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-04

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9767-6; CERCLA-04-2012-3780] Ellman Battery Superfund Site... Action at the Ellman Battery Superfund Site located in Orlando, Orange County, Florida. DATES: The Agency... name Ellman Battery Superfund Site by one of the following methods: www.epa.gov/region4/superfund...

Capturing the Change. The Impact of Indochinese Refugees in Orange County; Challenges and Opportunities.

ERIC Educational Resources Information Center

Baldwin, C. Beth

This study was conducted to determine the effects of the influx of 56,000 Indochinese refugees into Orange County, California between 1975 and 1982 and to make recommendations for integrating these people into the local labor force. In order to identify employer needs, characteristics of the refugee population, and the perceptions of both the…

77 FR 71167 - Foreign-Trade Zone 37-Orange County, New York, Authorization of Production Activity, Takasago...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-29

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-58-2012] Foreign-Trade Zone 37--Orange County, New York, Authorization of Production Activity, Takasago International Corporation (Fragrances), Harriman, New York On July 26, 2012, Takasago International Corporation (Takasago) submitted a notification...

Estimation of recharge through selected drainage wells and potential effects from well closure, Orange County, Florida

USGS Publications Warehouse

Bradner, L.A.

1996-01-01

Drainage wells have been used in Orange County, Florida, and surrounding areas to alleviate flooding and to control lake levels since 1904. Over 400 drainage wells have been drilled in the county, but many are now redundant because of surface drainage systems that have been installed within the last two or three decades. Most of the drainage wells emplace water into the Upper Floridan aquifer, a zone of high transmissivity within the Floridan aquifer system. In 1992, the Orange County Stormwater Management Department identified 23 wells that were considered noncritical or redundant for current drainage control. These wells were targeted for closure to eliminate maintenance and possible contamination problems. A 3-year study (1992 through 1994) encompassed several drainage basins in the county. Inflow to 18 of the 23 drainage wells on the noncritical list and the effects of closure of these noncritical wells on the potentiometric surface of the Upper Floridan aquifer were estimated. Three sites were chosen for intensive study and were used for further extrapolation to other noncritical sites. The total average annual recharge rate through the 18 selected wells was estimated to be 9 cubic feet per second, or about 6 million gallons per day. The highest rate of long-term recharge, 4.6 cubic feet per second, was to well H-35. Several wells on the noncritical list were already plugged or had blocked intakes. Yields, or the sum of surface-water outflows and drainage-well recharge, from the drainage basins ranged from 20 to 33 inches per year. In some of the basins, all the yield from the basin was recharge through a drainage well. In other basins, most of the yield was surface outflow through canals rather than to drainage wells. The removal of the recharge from closure of the wells was simulated by superposition in a three-dimensional ground-water flow model. As a second step in the model, water was also applied to two sites in western Orange County that could receive

Connector well experiment to recharge the Floridan Aquifer, East Orange County, Florida

USGS Publications Warehouse

Bush, P.W.

1979-01-01

An experimental connector well, screened in the shallow sand aquifer, finished with open hole in the Floridan aquifer, and cased through the confining layer between the two aquifers, was drilled in east Orange County, Florida, to obtain information on the nature and function of the shallow aquifer as related to connector well operation. The potentiometric surface of the shallow aquifer is about 45 feet higher than the potentiometric surface of the Floridan aquifer; hence water flows by gravity from the shallow aquifer to the Floridan aquifer through the well ' connecting ' the two aquifers. Continuous flow measurement over 10 months shows the well discharge varies seasonally and averages slightly more than 50 gallons per minute. Observation wells show that, except for seasonal variation water levels within the area of influence have reached steady state within measurable limits. Vertical anisotrophy in the shallow aquifer is apparently caused by the shape and (or) arrangement of the sand grains that comprise the shallow aquifer , rather than distinct confining layers of different lithology. Transmissivity of the shallow aquifer at the site is about 600 square feet per day. Extensive dewatering of wetlands in east Orange County by connector wells alone is probably not feasible. Nevertheless, large amounts of water could be channeled to the Floridan aquifer by connector wells. The results of the connector well experiment imply that water is being captured from evapotranspiration and runoff in the vicinity of the connector well. (Woodard-USGS)

75 FR 29727 - Reorganization of Foreign-Trade Zone 37 Under Alternative Site Framework Orange County, NY

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-27

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [Order No. 1680] Reorganization of Foreign-Trade Zone 37 Under Alternative Site Framework Orange County, NY Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U.S.C. 81a-81u), the Foreign-Trade Zones Board (the...

ANAEROBIC DEGRADATION OF MTBE TO TBA IN GROUND WATER AT GASOLINE SPILL SITES IN ORANGE COUNTY, CALIFORNIA

EPA Science Inventory

Although tert-Butyl Alcohol (TBA) has not been used as a fuel oxygenate in Orange County, California, the concentrations of TBA in ground water at gasoline spill sites are high compared to the concentrations of the conventional fuel oxygenate Methyl tert-Butyl Ether (MTBE). In t...

Development of ground-water resources in Orange County, Texas, and adjacent areas in Texas and Louisiana, 1971-80

USGS Publications Warehouse

Bonnet, C.W.; Gabrysch, R.K.

1982-01-01

Although saltwater encroachment is evident in parts of southern Orange County, the encroachment is not expected to be detrimental if the ground-water pumping remains stable and the projected increase in demands for water is met with surface-water supplies.

Final report on isotope tracer investigations in the Forebay of the Orange County groundwater basin.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davisson, M; Woodside, G

2003-12-13

California is currently faced with some critical decisions about water resource infrastructure development in highly urbanized regions, whose outcome will dictate the future long-term viability of plentiful water. Among these is developing and safely implementing the reuse of advanced treated waste water. One of the most reliable strategies for this water resource is its indirect reuse via groundwater recharge and storage, with particular emphasis on supplementing annual water demand or during drought relief. The Orange County Water District (District) is currently implementing the first phase of a large-scale water reuse project that will advance-treat up to 60 million gallons permore » day of waste water and recharge it into existing percolation basins in the Forebay region of the Orange County groundwater basin. In order for the District to protect public health, the fate and potability of this recharged waste water needs to be understood. In particular, the direction and rates of flow into underlying aquifers need to be characterized so that changes in water quality can be quantified between the recharge basins and points of production. Furthermore, to ensure compliance to California Department of Health Services (DHS) draft regulations, the direction and rate of recharged waste water from these basins need to be understood to sufficient detail that small mixtures can be delineated in monitoring and production wells. Under proposed DHS guidelines, consumptive use of recycled water is permissive only if its residence time in an aquifer exceeds a specified six-month time-frame. DHS guidelines also limit the percentage of recycled water at production wells. However, attaining such detail using current hydrogeological and computer-assisted modeling tools is either cost-prohibitive or results in uncertainties too large to achieve regulatory confidence. To overcome this technical barrier, the District funded Lawrence Livermore National Laboratory (LLNL) from 1995

Keys to the Common Genera of Marine Plants Taken Aboard the Orange County Floating Marine Laboratory.

ERIC Educational Resources Information Center

Williams, H. R.

Provided is a dichotomous key to the common genera of marine algae and angiosperms which are taken aboard the Orange County Floating Marine Laboratory. It is designed primarily for use by junior and senior high school students. Drawings of representative members of the various genera are included. This work was prepared under an ESEA Title III…

Ground-water hydrology of the Cocoa well-field area, Orange County, Florida

USGS Publications Warehouse

Tibbals, C.H.; Frazee, J.M.

1976-01-01

The city of Cocoa, Brevard County, Florida, supplies water for much of central Brevard County including Cape Kennedy and Patrick Air Force Base. The water supply is obtained from a well field in east Orange County. Many of the easternmost wells in that well field yield salty water (chloride concentration greater than 250 milligrams per liter). The interface between the fresh and salty water in the west part of the well field occurs at a depth of about 1,400 feet. An upward hydraulic gradient exists between the the lower (salty) zones and the upper, or pumped zones of the Floridan aquifer in the west part of the well field. Secondary artesian aquifers in the well-field area are relatively high-yielding but are of limited areal extent. However, they are suitable as a source of water for supplemental supply or for artificially recharging the Floridan aquifer. Fresh water was transferred by siphon from a secondary artesian aquifer to the Floridan aquifer at 90 gallons per minute. Artificial recharge and recovery experiments show that it is feasible to retrieve fresh water stored in salty zones of the Floridan aquifer. (Woodard-USGS)

IDENTIFYING THE CAUSE OF HIGH CONCENTRATIONS OF TBA IN GROUNDWATER AT GASOLINE SPIILL SITES IN ORANGE COUNTY, CALIFORNIA

EPA Science Inventory

Monitoring at gasoline spills in Orange County, California has revealed that TBA (tertiary butyl alcohol) is often present at high concentrations in ground water. To manage the hazard associated with the presence of TBA, staff of the UST Local Oversight Program (LOP) of the Oran...

General Services Administration Semiannual Regulatory Agenda

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-20

... products and services to be used to facilitate recovery from a major disaster declared by the President or... Services Administration Semiannual Regulatory Agenda] Part XVI General Services Administration Semiannual Regulatory Agenda [[Page 79860

8. August, 1970 PUMP BEHIND PELEG COGGESHALL HOUSE, 10 ORANGE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. August, 1970 PUMP BEHIND PELEG COGGESHALL HOUSE, 10 ORANGE STREET (MASS-1063) - Orange & Union Streets Neighborhood Study, 8-31 Orange Street, 9-21 Union Street & Stone Alley, Nantucket, Nantucket County, MA

Hydrology of Lake Butler, Orange County, Florida

USGS Publications Warehouse

Smoot, James L.; Schiffer, Donna M.

1984-01-01

Lake Butler is one of the lakes that collectively make up the Butler chain of lakes in the headwaters of the Kissimmee River, Florida. The bottom configuration of the lake is typical of relict karst features formed during lower stages in sea level. The top of the Floridan aquifer is 50 to 100 feet below the land surface. The drainage area of Lake Butler is approximately 14.5 sq mi and is comprised of sub-basins of other lakes in the vicinity. Surface outflow from Lake Butler is generally southward to Cypress Creek, a tributary of the Kissimmee River. The extremes in lake stage for the period 1933-81 are 94.67 ft on June 23, 1981 and 101.78 ft on September 13, 1960. The median lake stage for this period was 99.28 ft above sea level. The quality of water in Lake Butler is excellent, based on studies of physical, chemical, and biological conditions by the Orange County Pollution Control Department. The lake water is slightly acidic and soft (48 mg/L hardness as calcium carbonate). Pesticides in water were below detection levels at two sites sampled in the lake, but were detected in the bottom sediments. (USGS)

Toward the 21st Century: Preparing Proactive Visionary Transformational Leaders for Building Learning Communities. Human Resource Development. Orange County Cluster.

ERIC Educational Resources Information Center

Groff, Warren H.

This document describes the Orange County Cluster human resources development (HRD) seminar that was conducted as part of Nova University's nontraditional practitioner-oriented, problem-solving, field-based distance education program in higher education. Discussed first are HRD in the agricultural and business industrial eras and changing HRD…

77 FR 30504 - Certain Orange Juice From Brazil: Notice of Rescission of Antidumping Duty Administrative Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-23

... Brazil: Notice of Rescission of Antidumping Duty Administrative Review AGENCY: Import Administration... Administrative Review'' of the antidumping duty order on certain orange juice (OJ) from Brazil for a period of... Trade Commission determined that revocation of the antidumping duty order on OJ from Brazil would not be...

77 FR 63291 - Certain Orange Juice From Brazil: Final Results of Antidumping Duty Administrative Review and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-16

... Brazil: Final Results of Antidumping Duty Administrative Review and Final No Shipment Determination... orange juice (OJ) from Brazil. This review covers four producers/exporters of the subject merchandise to... 2010-2011 administrative review of antidumping duty order on certain OJ from Brazil.\\1\\ Also in April...

Small Business Administration Semiannual Regulatory Agenda

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-20

... represent that it will make good faith efforts to award subcontracts to small businesses at the same...). It also conforms SBA rules for the section 7(a) Business Loan Program and the Certified Development... Business Administration Semiannual Regulatory Agenda] Part XVII Small Business Administration Semiannual...

CONTROL OF STREPTOCOCCAL THROAT INFECTIONS IN SCHOOLS—A Cooperative Program Followed in Orange County

PubMed Central

Russell, Edward Lee

1956-01-01

Attempts to identify streptococcal throat infections on clinical evidence alone do not provide an adequate or reliable index of the prevalence of these infections in the community. Epidemiologic information on streptococcal throat infections based on bacteriological identification permits a more accurate assessment of the situation and more logical and more effective control measures. Recent refinements in laboratory procedures have provided a simple, reliable and relatively inexpensive method for the identification of Group A beta hemolytic streptococci by public health or clinical laboratories. In Orange County a program for the identification of streptococcal throat infections by cooperative action of the medical profession, the health department and the school authorities greatly aided in control of the disease. A voluntary health agency (heart association) made an important contribution toward the success of the control program. PMID:13374555

21 CFR 74.250 - Orange B.

Code of Federal Regulations, 2013 CFR

2013-04-01

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES SUBJECT TO CERTIFICATION Foods § 74.250 Orange B. (a) Identity. (1) The color additive Orange B is.... (2) The diluents in color additive mixtures for food use containing Orange B are limited to those...

21 CFR 74.250 - Orange B.

Code of Federal Regulations, 2012 CFR

2012-04-01

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES SUBJECT TO CERTIFICATION Foods § 74.250 Orange B. (a) Identity. (1) The color additive Orange B is.... (2) The diluents in color additive mixtures for food use containing Orange B are limited to those...

21 CFR 74.250 - Orange B.

Code of Federal Regulations, 2011 CFR

2011-04-01

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES SUBJECT TO CERTIFICATION Foods § 74.250 Orange B. (a) Identity. (1) The color additive Orange B is.... (2) The diluents in color additive mixtures for food use containing Orange B are limited to those...

21 CFR 74.250 - Orange B.

Code of Federal Regulations, 2014 CFR

2014-04-01

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES SUBJECT TO CERTIFICATION Foods § 74.250 Orange B. (a) Identity. (1) The color additive Orange B is.... (2) The diluents in color additive mixtures for food use containing Orange B are limited to those...

21 CFR 146.137 - Frozen orange juice.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Frozen orange juice. 146.137 Section 146.137 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR... Beverages § 146.137 Frozen orange juice. (a) Frozen orange juice is orange juice as defined in § 146.135...

76 FR 76491 - Economic Development Administration Regulatory Revision

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-07

... Vol. 76 Wednesday, No. 235 December 7, 2011 Part II Department of Commerce Economic Development Administration 13 CFR Parts 300, 301, 302, et al. Economic Development Administration Regulatory Revision...;#0; [[Page 76492

Increasing Storm Water Capture for Water Supply using Forecast Informed Reservoir Operations (FIRO) in Orange County, California

NASA Astrophysics Data System (ADS)

Hutchinson, A.; Woodside, G.; Ralph, F. M.

2017-12-01

Stormwater represents a significant source of water used by the Orange County Water District (OCWD) to recharge the Orange County groundwater basin. Over the last 20 years, OCWD has captured and recharged an average of 50,000 acre-feet per year (afy) of stormwater. Much of this recharge is made possible by the capture of stormwater in the Prado Dam Conservation Pool. OCWD has and continues to work closely with the US Army Corps of Engineers (USACE) to manage the conservation pool and to increase the amount of water that can be temporarily impounded in the conservation pool. Currently, the Conservation Pool is allowed to rise to elevation 498 ft msl (approx. 10,000 af of storage) during the storm season and to 505 ft msl (approx. 20,000 af of storage) during the non-storm season. OCWD has been working with the USACE on a Feasibility Study to permanently allow for storage of stormwater up to elevation 505 msl year-round. Even though increasing the Conservation Pool will increase the amount of stormwater captured, the weather forecasting used to manage the conservation pool can be improved in order to minimize lost opportunities to capture water or unnecessary releases of water to the ocean. To increase the efficiency of stormwater capture, OCWD is partnering with the Center for Western Weather and Water Extremes (http://cw3e.ucsd.edu/) to study the viability of using Forecast-Informed Reservoir Operations (FIRO) at Prado Dam. FIRO represents the next generation of operating water reservoirs using the best available technology. Moreover, given the importance of atmospheric river (AR) storms on water supplies in California, FIRO represents a methodology to take advantage of our increasing understanding of AR storms which are infrequent but provide a large percentage of total precipitation.

Orange County road orders, 1734-1749.

DOT National Transportation Integrated Search

1984-01-01

The establishment and maintenance of public roads were among the most important functions of the county court during the colonial period in Virginia. Each road was opened and maintained by an overseer (or surveyor) of the highways, who was appointed ...

Orange County road orders, 1750-1800.

DOT National Transportation Integrated Search

1989-01-01

The establishment and maintenance of public roads were among the most important functions of the county court during the colonial period in Virginia. Each road was opened and maintained by an overseer (or surveyor) of the highways, who was appointed ...

A Phase 1 Pharmacokinetic Study of Cysteamine Bitartrate Delayed-Release Capsules Following Oral Administration with Orange Juice, Water, or Omeprazole in Cystinosis.

PubMed

Armas, Danielle; Holt, Robert J; Confer, Nils F; Checani, Gregg C; Obaidi, Mohammad; Xie, Yuli; Brannagan, Meg

2018-02-01

Cystinosis is a rare, metabolic, autosomal recessive, genetic lysosomal storage disorder characterized by an accumulation of cystine in various organs and tissues. Cysteamine bitartrate (CB) is a cystine-depleting aminothiol agent approved in the United States and Europe in immediate-release and delayed-release (DR) formulations for the treatment of nephropathic cystinosis in children and adults. It is recommended that CBDR be administered with fruit juice (except grapefruit juice) for maximum absorption. Omeprazole is a proton pump inhibitor that inhibits gastric acid secretion and, theoretically, may cause the premature release of cysteamine by increasing intragastric pH, thereby affecting the PK of CBDR. This open-label, three-period, randomized study in healthy adult subjects was designed primarily to compare the pharmacokinetics of CBDR capsules after a single oral dose administered with orange juice, water, or multiple oral doses of omeprazole with water at steady state. A total of 32 subjects were randomly assigned to receive study agents in one of two treatment sequences. All subjects completed the study and baseline characteristics of the overall population and the two treatment sequence populations were similar. Peak mean plasma cysteamine concentrations following co-administration of CBDR capsules with orange juice (1892 ng/mL) were higher compared with co-administration with water (1663 ng/mL) or omeprazole 20 mg and water (1712 ng/mL). Mean time to peak plasma concentration was shorter with omeprazole co-administration (2.5 h) compared with orange juice (3.5 h) or water (3.0 h). Statistical comparisons between treatment groups indicated that exposure as assessed by AUC 0-t , AUC 0-∞ , and C max were all within the 80-125% bioequivalence ranges for all comparisons. All treatments were generally well tolerated. Overall, the pharmacokinetics of cysteamine bitartrate DR capsules are not significantly impacted by co-administration with orange juice

77 FR 6517 - Economic Development Administration Regulatory Revision; Comment Period Extension

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-08

... DEPARTMENT OF COMMERCE Economic Development Administration 13 CFR Parts 300, 301, 302, 303, 304... Development Administration Regulatory Revision; Comment Period Extension AGENCY: Economic Development.... SUMMARY: On December 7, 2011, the Department of Commerce's Economic Development Administration (EDA...

Near-conservative behavior of 129Iodine in the Orange County Aquifer System, California

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schwer, K A; Santschi, P H; Moran, J E

Iodine is a biophilic element, with one stable isotope, {sup 127}I, and one long-lived radioisotope, {sup 129}I, which originates in the surface environment almost entirely from anthropogenic activities such as nuclear fuel reprocessing. Very few studies have evaluated the geochemical behavior of iodine isotopes in the subsurface. The concentrations of {sup 129}I and {sup 127}I were measured in wells fed by a series of artificial recharge ponds in the Forebay Area of the Orange County groundwater basin (California, USA) to evaluate their potential use as hydrological tracers. To substantiate interpretation of {sup 129}I and {sup 127}I concentration data, the aquifermore » system was evaluated using literature values of aquifer water mass age based on {sup 3}H/{sup 3}He, Xenon and {delta}{sup 18}O tracer data, as well as time-series data of Santa Ana River flow rates over the past decade. The aquifer data demonstrate the nearly conservative behavior of {sup 129}I, with {sup 129}I/{sup 127}I ratios likely reflecting variations in source functions as well as climatic conditions, and with inferred particle-water partition coefficients (K{sub d}) of 0.1 cm{sup 3} g{sup -1} or less.« less

76 FR 35886 - Orange Cove Irrigation District, and Friant Power Authority; Notice of Availability of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-20

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 11068-014--California] Orange Cove Irrigation District, and Friant Power Authority; Notice of Availability of Environmental... has prepared an Environmental Assessment (EA) regarding Orange Cove Irrigation District's and Friant...

Assessing urban forest effects and values: Douglas County, Kansas

Treesearch

David J. Nowak; Allison R. Bodine; Robert E. Hoehn; Alexis Ellis; Kim Bomberger; Daniel E. Crane; Theodore A. Endreny; Thomas Taggert; Emily. Stephan

2014-01-01

An analysis of trees in Douglas County, Kansas, reveals that this area has about 14,164,000 trees with tree and shrub canopy that covers 25.2 percent of the county. The most common tree species are American elm, northern hackberry, eastern redcedar, Osage-orange, and honeylocust. Trees in Douglas County currently store about 1.7 million tons of carbon (6.4 million tons...

Administrative Record Introduction, American Drum & Pallet Co. Removal Site, Memphis, Shelby County, Tennessee

EPA Pesticide Factsheets

Introduction to a document that contains the Index to and the Administrative Record for the American Drum & Pallet Co. Removal Site, Memphis, Shelby County, Tennessee. Region ID: 04 DocID: 10517014, DocDate: 08-17-2007

21 CFR 74.1260 - D&C Orange No. 10.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false D&C Orange No. 10. 74.1260 Section 74.1260 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES SUBJECT TO CERTIFICATION Drugs § 74.1260 D&C Orange No. 10. (a) Identity. (1) The color...

21 CFR 74.1254 - D&C Orange No. 4.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false D&C Orange No. 4. 74.1254 Section 74.1254 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES SUBJECT TO CERTIFICATION Drugs § 74.1254 D&C Orange No. 4. (a) Identity. (1) the color additive D...

21 CFR 74.1261 - D&C Orange No. 11.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false D&C Orange No. 11. 74.1261 Section 74.1261 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES SUBJECT TO CERTIFICATION Drugs § 74.1261 D&C Orange No. 11. (a) Identity. (1) The color...

21 CFR 74.1255 - D&C Orange No. 5.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false D&C Orange No. 5. 74.1255 Section 74.1255 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES SUBJECT TO CERTIFICATION Drugs § 74.1255 D&C Orange No. 5. (a) Identity. (1) the color additive D...

21 CFR 73.3112 - C.I. Vat Orange 1.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false C.I. Vat Orange 1. 73.3112 Section 73.3112 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Medical Devices § 73.3112 C.I. Vat Orange 1. (a) Identity. The...

21 CFR 73.3112 - C.I. Vat Orange 1.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 1 2012-04-01 2012-04-01 false C.I. Vat Orange 1. 73.3112 Section 73.3112 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Medical Devices § 73.3112 C.I. Vat Orange 1. (a) Identity. The...

21 CFR 73.3112 - C.I. Vat Orange 1.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 1 2014-04-01 2014-04-01 false C.I. Vat Orange 1. 73.3112 Section 73.3112 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Medical Devices § 73.3112 C.I. Vat Orange 1. (a) Identity. The...

21 CFR 73.3112 - C.I. Vat Orange 1.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false C.I. Vat Orange 1. 73.3112 Section 73.3112 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Medical Devices § 73.3112 C.I. Vat Orange 1. (a) Identity. The...

21 CFR 73.3112 - C.I. Vat Orange 1.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 1 2013-04-01 2013-04-01 false C.I. Vat Orange 1. 73.3112 Section 73.3112 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Medical Devices § 73.3112 C.I. Vat Orange 1. (a) Identity. The...

21 CFR 82.1255 - D&C Orange No. 5.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 5. 82.1255 Section 82.1255 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF CERTIFIED...) The color additive D&C Orange No. 5. may be safely used for coloring externally applied drugs in...

21 CFR 82.1255 - D&C Orange No. 5.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false D&C Orange No. 5. 82.1255 Section 82.1255 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF CERTIFIED...) The color additive D&C Orange No. 5. may be safely used for coloring externally applied drugs in...

Biochemical characterization of blood orange, sweet orange, lemon, bergamot and bitter orange.

PubMed

Moufida, Saïdani; Marzouk, Brahim

2003-04-01

This paper reports on the composition of aroma compounds and fatty acids and some physico-chemical parameters (juice percentage, acidity and total sugars) in five varieties of citrus: blood orange, sweet orange, lemon, bergamot and bitter orange. Volatile compounds and methyl esters have been analyzed by gas chromatography. Limonene is the most abundant compound of monoterpene hydrocarbons for all of the examined juices. Eighteen fatty acids have been identified in the studied citrus juices, their quantification points out that unsaturated acids predominate over the saturated ones. Mean concentration of fatty acids varies from 311.8 mg/l in blood orange juice to 678 mg/l in bitter orange juice. Copyright 2003 Elsevier Science Ltd.

Surface-water and karst groundwater interactions and streamflow-response simulations of the karst-influenced upper Lost River watershed, Orange County, Indiana

USGS Publications Warehouse

Bayless, E. Randall; Cinotto, Peter J.; Ulery, Randy L.; Taylor, Charles J.; McCombs, Gregory K.; Kim, Moon H.; Nelson, Hugh L.

2014-01-01

The U.S. Geological Survey (USGS), in cooperation with the U.S. Army Corps of Engineers (USACE) and the Indiana Office of Community and Rural Affairs (OCRA), conducted a study of the upper Lost River watershed in Orange County, Indiana, from 2012 to 2013. Streamflow and groundwater data were collected at 10 data-collection sites from at least October 2012 until April 2013, and a preliminary Water Availability Tool for Environmental Resources (WATER)-TOPMODEL based hydrologic model was created to increase understanding of the complex, karstic hydraulic and hydrologic system present in the upper Lost River watershed, Orange County, Ind. Statistical assessment of the optimized hydrologic-model results were promising and returned correlation coefficients for simulated and measured stream discharge of 0.58 and 0.60 and Nash-Sutcliffe efficiency values of 0.56 and 0.39 for USGS streamflow-gaging stations 03373530 (Lost River near Leipsic, Ind.), and 03373560 (Lost River near Prospect, Ind.), respectively. Additional information to refine drainage divides is needed before applying the model to the entire karst region of south-central Indiana. Surface-water and groundwater data were used to tentatively quantify the complex hydrologic processes taking place within the watershed and provide increased understanding for future modeling and management applications. The data indicate that during wet-weather periods and after certain intense storms, the hydraulic capacity of swallow holes and subsurface conduits is overwhelmed with excess water that flows onto the surface in dry-bed relic stream channels and karst paleovalleys. Analysis of discharge data collected at USGS streamflow-gaging station 03373550 (Orangeville Rise, at Orangeville, Ind.), and other ancillary data-collection sites in the watershed, indicate that a bounding condition is likely present, and drainage from the underlying karst conduit system is potentially limited to near 200 cubic feet per second. This

Allergenicity of orange juice and orange seeds: a clinical study.

PubMed

Zhu, S L; Ye, S T; Yu, Y

1989-06-01

Oranges are considered to be common allergenic fruits in China. They may induce severe food allergy in sensitive individuals. Allergic histories were analyzed in 26 orange-sensitive patients. Intradermal tests with extracts of orange juice and seeds were performed in 16 out of the 26 patients. P-K test was performed in one patient. The allergic history analysis suggested that clinical symptoms of some orange-allergic subjects were different from other fruit allergies but similar to nut and other oil plant seed allergies. The skin test and P-K test showed that the major allergenic components of orange reside in orange seeds instead of orange juice. Systemic reactions developed in 5 patients after intradermal tests with 1:20-200 (w/v) orange seed extracts. We considered that orange seed contains high potent allergens which may induce orange sensitivity due to careless chewing of orange seeds.

In vitro studies on immunotoxic potential of Orange II in splenocytes.

PubMed

Yadav, Ashish; Kumar, Arvind; Dwivedi, Premendra Dhar; Tripathi, Anurag; Das, Mukul

2012-02-05

Orange II, an azo dye, is not permitted in food preparations, but high levels of the dye have been detected in different food commodities. Though there are reports on the toxicity of Orange II but knowledge based on the immunomodulatory properties of Orange II is scanty. The present investigation was undertaken to study the in vitro immunotoxic potential of Orange II in splenocytes. Splenocytes were isolated, cultured and subjected to immunophenotypic analysis, mixed lymphocyte reaction (MLR) assay or stimulated with lipopolysaccharide (LPS) or concanavalin A (Con A) for 72 h. The supernatant was collected for cytokine assays. Orange II showed cytotoxic effects at 100-1000μg/ml concentrations and 50μg/ml was determined as the highest non-cytotoxic dose. Orange II at the non-cytotoxic dose (50μg/ml) significantly altered the relative distribution of T and B-cells, MLR response and the mitogen induced proliferative response of T-cells and B-cells. Consistent with the hypo-responsiveness of the T and B-lymphocytes, Orange II induced a concomitant decline in the secretion of cytokines IL-2, IL-4, IL-6, IFN-γ, TNF-α and IL-17. On the contrary, there was an increase in the production of IL-10, an anti-inflammatory regulatory cytokine, which may be one of the causative factor for immunosuppressive property of Orange II. These results suggest that non-cytotoxic dose of Orange II may have immunomodulatory effects. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Changes in FDA enforcement activities following changes in federal administration: the case of regulatory letters released to pharmaceutical companies.

PubMed

Nguyen, Diane; Seoane-Vazquez, Enrique; Rodriguez-Monguio, Rosa; Montagne, Michael

2013-01-22

The United States (US) Food and Drug Administration (FDA) is responsible for the protection of the public health by assuring the safety, effectiveness and security of human drugs and biological products through the enforcement of the Federal Food, Drug and Cosmetic Act (FDCA) and related regulations. These enforcement activities include regulatory letters (i.e. warning letters and notice of violation) to pharmaceutical companies. A regulatory letter represents the FDA's first official notification to a pharmaceutical company that the FDA has discovered a product or activity in violation of the FDCA.This study analyzed trends in the pharmaceutical-related regulatory letters released by the FDA during the period 1997-2011 and assessed differences in the average number and type of regulatory letters released during the last four federal administrations. Data derived from the FDA webpage. Information about the FDA office releasing the letter, date, company, and drug-related violation was collected. Regulatory letters were classified by federal administration. Descriptive statistics were performed for the analysis. Between 1997 and 2011 the FDA released 2,467 regulatory letters related to pharmaceuticals. FDA headquarters offices released 50.6% and district offices 49.4% of the regulatory letters. The Office of Prescription Drug Promotion released the largest number of regulatory letters (850; 34.5% of the total), followed by the Office of Scientific Investigations (131; 5.3%), and the Office of Compliance (105; 4.3%). During the 2nd Clinton Administration (1997-2000) the average number of regulatory letters per year was 242.8 ± 45.6, during the Bush Administration (2001-2008) it was 120.4 ± 33.7, and during the first three years of the Obama administration (2009-2011) it was 177.7.0 ± 17.0. The average number of regulatory letters released by the Office of Prescription Drug Promotion also varied by administration: Clinton (122.3 ± 36.4), Bush (29.5�

76 FR 19373 - The 14th Annual Food and Drug Administration-Orange County Regulatory Affairs Educational...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-07

... (OCRA). The conference is intended to provide the drug, device, biologics, and dietary supplement... will be product approval, compliance, and risk management in the three medical product areas. Industry...

75 FR 29559 - The 13th Annual Food and Drug Administration-Orange County Regulatory Affairs Educational...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-26

... and dietary supplement industries with an opportunity to interact with FDA reviewers and compliance... interactive conference will be product approval, compliance, and risk management in the four medical product...

77 FR 24721 - The 15th Annual Food and Drug Administration-Orange County Regulatory Affairs Educational...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-25

... Group (OCRA). The conference is intended to provide the drug, device, biologics, and dietary supplement... product approval, compliance, and risk management in the three medical product areas. Industry speakers...

METRO-APEX Volume 19.1: City Manager and County Administrative Officer's Manual. Revised.

ERIC Educational Resources Information Center

University of Southern California, Los Angeles. COMEX Research Project.

The City Manager and County Administrative Officer's Manual is one of a set of twenty-one manuals used in METRO-APEX 1974, a computerized college and professional level, computer-supported, role-play, simulation exercise of a community with "normal" problems. Stress is placed on environmental quality considerations. APEX 1974 is an…

Contaminants in sediment, food-chain biota, and bird eggs from the Newport Bay watershed, Orange County, California.

PubMed

Santolo, Gary M; Byron, Earl R; Ohlendorf, Harry M

2016-02-01

Groundwater-related discharges in the San Diego Creek/Newport Bay watershed in Orange County, California have the potential to adversely affect the surface waters within the watershed and would likely not comply with the established total maximum daily loads (TMDLs) for the watershed. In 2004 and 2005, we studied the concentrations of contaminants of TMDL concern (particularly selenium [Se]) in birds that are at risk of exposure to contaminated food items because they feed and nest in the Newport Bay watershed. Most bioaccumulation is from elevated Se in groundwater downstream of a historic terminal swamp. Se bioaccumulation was observed in all biota tested, and DDE was found in fish and bird egg samples. Effects of contaminants on fish and birds are inconclusive due to the management disturbances in the watershed (e.g., flood control) and lack of bird nesting habitat. Although a significant relationship was observed between DDE concentrations and eggshell thinning in American avocet (Recurvirostra americana) eggs, the shell thinning in avocet and other species examined was not enough to result in hatching failure. Further focused monitoring efforts will be needed to characterize the exposure and risk levels.

Microbial safety and quality of fresh herbs from Los Angeles, Orange County and Seattle farmers' markets.

PubMed

Levy, Donna J; Beck, Nicola K; Kossik, Alexandra L; Patti, Taylor; Meschke, J Scott; Calicchia, Melissa; Hellberg, Rosalee S

2015-10-01

Farmers' markets have been growing in popularity in the United States, but the microbial quality and safety of the food sold at these markets is currently unknown. The purpose of this study was to assess the microbial safety and quality of fresh basil, parsley and cilantro sold at farmers' markets in the Los Angeles, Orange County and greater Seattle areas. A total of 133 samples (52 basil, 41 cilantro and 40 parsley) were collected from 13 different farmers' markets and tested for Salmonella and generic Escherichia coli. One sample (parsley) was confirmed positive for Salmonella and 24.1% of samples were positive for generic E. coli, with a range of 0.70-3.15 log CFU g(-1) . Among the herbs tested, basil showed the highest percentage of samples with generic E. coli (26.9%), followed by cilantro (24.4%) and then parsley (20.0%). For 12% of samples, the levels of generic E. coli exceeded guidelines established by the Public Health Laboratory Service for microbiological quality of ready-to-eat foods. Overall, this study indicates the presence of Salmonella and generic E. coli in fresh herbs sold at farmers' markets; however, additional studies are needed to determine the sources and extent of contamination. © 2014 Society of Chemical Industry.

75 FR 25308 - Environmental Impact Statement: Winnebago County, IL and Rock County, WI

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-07

... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Environmental Impact Statement: Winnebago County, IL and Rock County, WI AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice... Nye School Road northwest of Beloit, Rock County, Wisconsin to the interchange of Rockton Road and I...

A photoswitchable orange-to-far-red fluorescent protein, PSmOrange.

PubMed

Subach, Oksana M; Patterson, George H; Ting, Li-Min; Wang, Yarong; Condeelis, John S; Verkhusha, Vladislav V

2011-07-31

We report a photoswitchable monomeric Orange (PSmOrange) protein that is initially orange (excitation, 548 nm; emission, 565 nm) but becomes far-red (excitation, 636 nm; emission, 662 nm) after irradiation with blue-green light. Compared to its parental orange proteins, PSmOrange has greater brightness, faster maturation, higher photoconversion contrast and better photostability. The red-shifted spectra of both forms of PSmOrange enable its simultaneous use with cyan-to-green photoswitchable proteins to study four intracellular populations. Photoconverted PSmOrange has, to our knowledge, the most far-red excitation peak of all GFP-like fluorescent proteins, provides diffraction-limited and super-resolution imaging in the far-red light range, is optimally excited with common red lasers, and can be photoconverted subcutaneously in a mouse. PSmOrange photoswitching occurs via a two-step photo-oxidation process, which causes cleavage of the polypeptide backbone. The far-red fluorescence of photoconverted PSmOrange results from a new chromophore containing N-acylimine with a co-planar carbon-oxygen double bond.

County of Hawai’i: Administrative Order on Consent; Docket No. SDWA-UIC-AOC-2017-0002

EPA Pesticide Factsheets

Documents related to the Administrative Order on Consent (“Consent Order”) between the U.S. Environmental Protection Agency Region 9 (“EPA”) and the County of Hawai‘i. Docket No. SDWA-UIC-AOC-2017-0002.

75 FR 69917 - Certain Orange Juice From Brazil; Notice of Extension of Time Limits for Preliminary Results of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-16

... DEPARTMENT OF COMMERCE International Trade Administration [A-351-840] Certain Orange Juice From Brazil; Notice of Extension of Time Limits for Preliminary Results of Antidumping Duty Administrative... antidumping duty order on certain orange juice from Brazil. See Initiation of Antidumping and Countervailing...

76 FR 65496 - Certain Orange Juice From Brazil; Notice of Extension of Time Limits for Preliminary Results of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-21

... DEPARTMENT OF COMMERCE International Trade Administration [A-351-840] Certain Orange Juice From Brazil; Notice of Extension of Time Limits for Preliminary Results of Antidumping Duty Administrative... antidumping duty order on certain orange juice from Brazil. See Initiation of Antidumping and Countervailing...

Detection of oranges from a color image of an orange tree

NASA Astrophysics Data System (ADS)

Weeks, Arthur R.; Gallagher, A.; Eriksson, J.

1999-10-01

The progress of robotic and machine vision technology has increased the demand for sophisticated methods for performing automatic harvesting of fruit. The harvesting of fruit, until recently, has been performed manually and is quite labor intensive. An automatic robot harvesting system that uses machine vision to locate and extract the fruit would free the agricultural industry from the ups and downs of the labor market. The environment in which robotic fruit harvesters must work presents many challenges due to the inherent variability from one location to the next. This paper takes a step towards this goal by outlining a machine vision algorithm that detects and accurately locates oranges from a color image of an orange tree. Previous work in this area has focused on differentiating the orange regions from the rest of the picture and not locating the actual oranges themselves. Failure to locate the oranges, however, leads to a reduced number of successful pick attempts. This paper presents a new approach for orange region segmentation in which the circumference of the individual oranges as well as partially occluded oranges are located. Accurately defining the circumference of each orange allows a robotic harvester to cut the stem of the orange by either scanning the top of the orange with a laser or by directing a robotic arm towards the stem to automatically cut it. A modified version of the K- means algorithm is used to initially segment the oranges from the canopy of the orange tree. Morphological processing is then used to locate occluded oranges and an iterative circle finding algorithm is used to define the circumference of the segmented oranges.

21 CFR 146.135 - Orange juice.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Orange juice. 146.135 Section 146.135 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CANNED FRUIT JUICES Requirements for Specific Standardized Canned Fruit Juices and Beverages § 146...

77 FR 23659 - Revocation of Antidumping Duty Order: Certain Orange Juice From Brazil

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-20

... Duty Order: Certain Orange Juice From Brazil AGENCY: Import Administration, International Trade...) initiated a sunset review of the antidumping duty order on certain orange juice (OJ) from Brazil.\\1\\ On...), the Department is revoking the antidumping duty order on OJ from Brazil. \\1\\ See Initiation of Five...

The Environmental Protection Agency in the Early Trump Administration: Prelude to Regulatory Capture.

PubMed

Dillon, Lindsey; Sellers, Christopher; Underhill, Vivian; Shapiro, Nicholas; Ohayon, Jennifer Liss; Sullivan, Marianne; Brown, Phil; Harrison, Jill; Wylie, Sara

2018-04-01

We explore and contextualize changes at the Environmental Protection Agency (EPA) over the first 6 months of the Trump administration, arguing that its pro-business direction is enabling a form of regulatory capture. We draw on news articles, public documents, and a rapid response, multisited interview study of current and retired EPA employees to (1) document changes associated with the new administration, (2) contextualize and compare the current pro-business makeover with previous ones, and (3) publicly convey findings in a timely manner. The lengthy, combined experience of interviewees with previous Republican and Democratic administrations made them valuable analysts for assessing recent shifts at the Scott Pruitt-led EPA and the extent to which these shifts steer the EPA away from its stated mission to "protect human and environmental health." Considering the extent of its pro-business leanings in the absence of mitigating power from the legislative branch, we conclude that its regulatory capture has become likely-more so than at similar moments in the agency's 47-year history. The public and environmental health consequences of regulatory capture of the EPA will probably be severe and far-reaching.

The Environmental Protection Agency in the Early Trump Administration: Prelude to Regulatory Capture

PubMed Central

Sellers, Christopher; Underhill, Vivian; Shapiro, Nicholas; Ohayon, Jennifer Liss; Sullivan, Marianne; Brown, Phil; Harrison, Jill; Wylie, Sara

2018-01-01

We explore and contextualize changes at the Environmental Protection Agency (EPA) over the first 6 months of the Trump administration, arguing that its pro-business direction is enabling a form of regulatory capture. We draw on news articles, public documents, and a rapid response, multisited interview study of current and retired EPA employees to (1) document changes associated with the new administration, (2) contextualize and compare the current pro-business makeover with previous ones, and (3) publicly convey findings in a timely manner. The lengthy, combined experience of interviewees with previous Republican and Democratic administrations made them valuable analysts for assessing recent shifts at the Scott Pruitt–led EPA and the extent to which these shifts steer the EPA away from its stated mission to “protect human and environmental health.” Considering the extent of its pro-business leanings in the absence of mitigating power from the legislative branch, we conclude that its regulatory capture has become likely—more so than at similar moments in the agency’s 47-year history. The public and environmental health consequences of regulatory capture of the EPA will probably be severe and far-reaching. PMID:29698086

Assessing the Effects of Climate Variability on Orange Yield in Florida to Reduce Production Forecast Errors

NASA Astrophysics Data System (ADS)

Concha Larrauri, P.

2015-12-01

Orange production in Florida has experienced a decline over the past decade. Hurricanes in 2004 and 2005 greatly affected production, almost to the same degree as strong freezes that occurred in the 1980's. The spread of the citrus greening disease after the hurricanes has also contributed to a reduction in orange production in Florida. The occurrence of hurricanes and diseases cannot easily be predicted but the additional effects of climate on orange yield can be studied and incorporated into existing production forecasts that are based on physical surveys, such as the October Citrus forecast issued every year by the USDA. Specific climate variables ocurring before and after the October forecast is issued can have impacts on flowering, orange drop rates, growth, and maturation, and can contribute to the forecast error. Here we present a methodology to incorporate local climate variables to predict the USDA's orange production forecast error, and we study the local effects of climate on yield in different counties in Florida. This information can aid farmers to gain an insight on what is to be expected during the orange production cycle, and can help supply chain managers to better plan their strategy.

Determination of the LD50 of acridine orange via intravenous administration in mice in preparation for clinical application to cancer therapy.

PubMed

Nakamura, Tomoki; Kusuzaki, Katsuyuki; Matsubara, Takao; Matsumine, Akihiko; Asanuma, Kunihiro; Satonaka, Haruhiko; Uchida, Atsumasa; Sudo, Akihiro

2014-01-01

We undertook studies to determine the lethal dose 50 (LD50) of acridine orange (AO) using mice in order to confirm the safety of intravenous administration of AO. We used 40 mice and AO was administered once intravenously. General behavior and mortality were continuously observed for 14 days. At the end of the experiment, all animals were sacrificed for subsequent studies. The LD50 for AO in male and female mice was determined to be 32 mg/kg and 36 mg/kg, respectively. Histopathological abnormalities were observed in only one mouse which died three days after the administration of AO. The other nine mice which died immediately after the administration of AO had no pathological findings in major organs. The clinical use of AO can be kept at 1.0 mg/kg or below and, therefore, intravenous administration of AO might be safe for use as cancer therapy. Copyright © 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

21 CFR 74.250 - Orange B.

Code of Federal Regulations, 2010 CFR

2010-04-01

... listed in part 73 of this chapter as safe and suitable in color additive mixtures for coloring foods. (b... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Orange B. 74.250 Section 74.250 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR...

Effectiveness of pilot connector well in artificial recharge of the Floridan aquifer, western Orange County, Florida

USGS Publications Warehouse

Watkins, Frank A.

1977-01-01

A connector well pilot installation, in continuous operation in western Orange County since December 4, 1970, was transferring water from the lower of two shallow sand aquifers to the Floridan aquifer at a rate of 13 gallons per minute when measured on September 23, 1971. The recharge water is untreated and analyses show it to be chemically and physically compatible with the water in the Floridan aquifer. The temperatures of the recharging and receiving waters were identical, 23 deg C. The transfer of water from the lower sand aquifer to the Floridan aquifer caused only a small buildup of artesian pressure in the Floridan aquifer but it lowered the artesian head 4 feet in the lower sand aquifer near the well which supplied the recharge water. Water levels in the upper sand aquifer were not affected, probably because of the low permeability of an intervening hardpan layer. However, after six auger holes back-filled with sand connected the two sand aquifers on April 5, 1972, a rise of water levels in the lower sand aquifer was noted. The principal chemical and physical effects on the water in the Floridan aquifer were a general improvement in chemical quality and an increase in color. The color may decrease as more water moves through the sand aquifer and the material responsible for the high color is removed by flushing. (Woodard-USGS)

Public health assessment for El Toro Marine Corps Air Station, Santa Ana, Orange County, California, Region 9. CERCLIS No. CA6170023208. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

El Toro Marine Corps Air Station is in Orange County, California, near the city of Irvine. The Marine Corps established El Toro in 1943, and it currently serves as the center for marine aviation operations on the Pacific Coast. El Toro Marine Corps Air Station was proposed for listing on EPA's National Priorities List (NPL) in 1989 because past operations and disposal practices contaminated local groundwater. Agricultural farm workers and well operators are exposed to contaminants in groundwater through unintentional ingestion of contaminated groundwater, dermal contact with contaminated groundwater, and inhalation of aerosolized groundwater contaminants. Future exposure could occur throughmore » two potable water wells that are located 10 miles downgradient of the contaminant plume. At the current rate of contaminant migration, those wells will be affected in one and a half to five years.« less

Tobacco regulatory science: research to inform regulatory action at the Food and Drug Administration's Center for Tobacco Products.

PubMed

Ashley, David L; Backinger, Cathy L; van Bemmel, Dana M; Neveleff, Deborah J

2014-08-01

The U.S. Food and Drug Administration (FDA) promotes the development of regulatory science to ensure that a strong evidence base informs all of its regulatory activities related to the manufacture, marketing, and distribution of tobacco products as well as public education about tobacco product constituents and effects. Toward that end, the FDA's Center for Tobacco Products (CTP) provides funding for research studies with scientific aims that fall within its defined regulatory authority. However, given their traditional biomedical focus on basic and applied research, some researchers may not understand the principles of regulatory science or the types of studies CTP funds. The purpose of this paper is (1) to clarify the definition of regulatory science as a distinct scientific discipline, (2) to explore the role of tobacco regulatory science in order to help researchers understand the parameters and types of research that can be funded by CTP, and (3) to describe the types of research efforts that will inform the FDA's public health framework for tobacco product regulation. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Pharmacokinetics and relative bioavailability of clofazimine in relation to food, orange juice and antacid.

PubMed

Nix, D E David E; Adam, R D Rodney D; Auclair, Barbara; Krueger, T S Todd S; Godo, P G Paul G; Peloquin, C A Charles A

2004-01-01

Clofazimine is potentially useful for the treatment of disease due to multidrug resistant Mycobacterium tuberculosis, as well as leprosy and certain chronic skin diseases. Its pharmacokinetics have been incompletely characterized. This study was conducted to explore issues relating to bioavailability in the presence of food, orange juice, and antacid. A 5 drug regimen consisting of clofazimine, cycloserine, ethionamide, para-aminosalicyclic acid, and pyridoxime was administered to healthy subjects four times using a four period cross-over design with two weeks washout between treatments. Subjects also received orange juice, a high fat meal, aluminum/magnesium antacid, or only water in random order with the drug regimen. The pharmacokinetics of clofazimine were assessed using individual- and population-based methods and relative bioavailability compared to fasting administration was determined. Clofazimine exhibited a sometimes prolonged and variable lag-time and considerable variability in plasma concentrations. From the population analysis (one-compartment model), the mean oral clearance was 76.7 l/h (CV=74.2%) and mean apparent volume of distribution was 1470 l (CV=36.3%). The first-order absorption rate constant ranged from 0.716 to 1.33 h(-1) (pooled CV=61.7%). Residual (proportional) error was 49.1%. Estimates of bioavailability compared to fasting administration were 145% (90% CI, 107-183%) for administration with high fat food, 82.0% (63.2-101%) for administration with orange juice, and 78.5% (55.1-102%) for administration with antacid. Administration of clofazimine with a high fat meal provides the greatest bioavailability, however, bioavailability is associated with high inter- and intra-subject variability. Both orange juice and aluminum-magnesium antacid produced a reduction in mean bioavailability of clofazimine.

Host status of grapefruit and Valencia oranges for Anastrepha serpentina and Anastrepha ludens

USDA-ARS?s Scientific Manuscript database

Anastrepha serpentina, known as the zapote fly or serpentine fruit fly, is occasionally captured in the Rio Grande Valley of Texas. Lists of host plants for this species include several species of citrus, such as oranges and grapefruit. Current regulatory procedures require quarantines and treatme...

21 CFR 146.151 - Orange juice for manufacturing.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Orange juice for manufacturing. 146.151 Section 146.151 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CANNED FRUIT JUICES Requirements for Specific Standardized Canned...

21 CFR 146.152 - Orange juice with preservative.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Orange juice with preservative. 146.152 Section 146.152 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CANNED FRUIT JUICES Requirements for Specific Standardized Canned...

A single amino acid substitution in an ORANGE protein promotes carotenoid overaccumulation in arabidopsis

USDA-ARS?s Scientific Manuscript database

Carotenoids are crucial for plant growth and human health. The finding of ORANGE (OR) protein as a pivotal regulator of carotenogenesis offers a unique opportunity to comprehensively understand the regulatory mechanisms of carotenoid accumulation and develop crops with enhanced nutritional quality. ...

Potential For Denitrification near Reclaimed Water Application Sites in Orange County, Florida, 2009

USGS Publications Warehouse

Byrne, Michael J.; Smith, Richard L.; Repert, Deborah A.

2012-01-01

The potential for denitrification was tested in water samples from four Upper Floridan aquifer wells near a reclaimed water application site, in west Orange County Florida, and two adjacent springs. Results of the study indicate that denitrifying bacteria are present in the groundwater and spring water samples, and that these bacteria can readily denitrify the waters when suitable geochemical conditions exist. The acetylene block technique was used to assess nitrous oxide in the samples that was produced by denitrification. The laboratory incubation experiment consisted of four different treatments to each of the six samples: (1) ambient water (no added nitrate or glucose), (2) ambient water amended with 1.4 milligrams per liter (mg/L) nitrate as nitrogen (N), (3) ambient water amended with 5.0 mg/L nitrate as N, and (4) ambient water amended with 5.0 mg/L nitrate as N and 10 mg/L glucose as C6H12O6. A companion set of incubations using treatment 2 tracked changes in nitrate and nitrite concentration with time. The rate of denitrification in treatment 2 ranged from 0.059 to 0.124 milligram per liter per day nitrogen [(mg/L)/d N] and in treatment 3 ranged from 0.071 to 0.226 (mg/L)/d N. At all of the sampling sites, treatment 4 yielded denitrification rates at least an order of magnitude greater than those measured for the other treatments; rates ranged from 2.3 to 4.4 (mg/L)/d N. The electron donor supply, dissolved organic carbon, in the groundwater and springwater is sufficient to remove at least 1.1-1.4 mg/L nitrate as N in 20 to 30 days, as indicated by nitrous oxide production rates under ambient conditions (treatment 1). The even higher nitrate removal observed with addition of supplemental carbon in treatment 4 suggests that carbon is a limiting nutrient in this reaction. Denitrifying activity might explain the low ambient nitrate concentrations in the Upper Floridan aquifer in this area.

General Services Administration Semiannual Regulatory Agenda

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-26

... regulatory plan. FOR FURTHER INFORMATION CONTACT: Hada Flowers, Supervisor, Regulatory Secretariat Branch, at... Required: Yes Agency Contact: Hada Flowers, Supervisor, Regulatory Secretariat Branch, Office of...: 202 501-4755 Fax: 202 501-4067 Email: hada.flowers@gsa.gov RIN: 3090-AI32 276. GSAR CASE 2008-G517...

21 CFR 146.153 - Concentrated orange juice for manufacturing.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Concentrated orange juice for manufacturing. 146.153 Section 146.153 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CANNED FRUIT JUICES Requirements for Specific Standardized...

21 CFR 146.154 - Concentrated orange juice with preservative.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Concentrated orange juice with preservative. 146.154 Section 146.154 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CANNED FRUIT JUICES Requirements for Specific Standardized...

The prevalence of asthma risk and contributing factors in underserved Vietnamese children in Orange County, CA.

PubMed

Nguyen, Tan; Kilgore, David; Morphew, Tricia; Tran, Jacqueline; Berg, Jill; Galant, Stanley

2015-01-01

Vietnamese constitutes one of the fastest growing minority groups in America, with the largest concentration in Orange County (OC), CA. Yet, there are limited data on the prevalence of asthma in Vietnamese children. Our study evaluated the risk of asthma and key contributing factors among these children living in OC, CA. Five elementary schools in OC that were predominantly Vietnamese with low socioeconomic status were selected for participation. Validated surveys were sent to parents of all students ages 3-12 in these schools with materials available in English, Vietnamese and Spanish. Surveys included questions to identify the risk of asthma and related key factors. Surveys were completed by parents and returned to schools. There were 1530 participants eligible for analysis. Asthma risk was 30.4%, and of these, 22.6% had no prior diagnosis. Contributing factors to identification of those at risk were male gender (p < 0.001), preferred use of the Vietnamese language (p = 0.004), longer duration in the United States (p = 0.019), and smoker in the household (p = 0.015). The prevalence of asthma risk in our community of low socioeconomic status Vietnamese children was found to be higher than commonly appreciated. Furthermore, a considerable number of these children had not been previously diagnosed. Given the limited information in this population, our current findings of asthma risk and key contributing factors could affect health care policies that allow appropriate funding for programs dedicated to asthma care in this and other growing population.

Development of a Real-Time GPS/Seismic Displacement Meter: Applications to Civilian Infrastructure in Orange and Western Riverside Counties, California

NASA Technical Reports Server (NTRS)

Bock, Yehuda

2005-01-01

We propose a three-year applications project that will develop an Integrated Real-Time GPS/Seismic System and deploy it in Orange and Western Riverside Counties, spanning three major strike-slip faults in southern California (San Andreas, San Jacinto, and Elsinore) and significant populations and civilian infrastructure. The system relying on existing GPS and seismic networks will collect and analyze GPS and seismic data for the purpose of estimating and disseminating real-time positions and total ground displacements (dynamic, as well as static) during all phases of the seismic cycle, from fractions of seconds to years. Besides its intrinsic scientific use as a real-time displacement meter (transducer), the GPS/Seismic System will be a powerful tool for local and state decision makers for risk mitigation, disaster management, and structural monitoring (dams, bridges, and buildings). Furthermore, the GPS/Seismic System will become an integral part of California's spatial referencing and positioning infrastructure, which is complicated by tectonic motion, seismic displacements, and land subsidence. Finally, the GPS/Seismic system will also be applicable to navigation in any environment (land, sea, or air) by combining precise real-time instantaneous GPS positioning with inertial navigation systems. This development will take place under the umbrella of the California Spatial Reference Center, in partnership with local (Counties, Riverside County Flood and Water Conservation District, Metropolitan Water District), state (Caltrans), and Federal agencies (NGS, NASA, USGS), the geophysics community (SCIGN/SCEC2), and the private sector (RBF Consulting). The project will leverage considerable funding, resources, and R&D from SCIGN, CSRC and two NSF-funded IT projects at UCSD and SDSU: RoadNet (Real-Time Observatories, Applications and Data Management Network) and the High Performance Wireless Research and Education Network (HPWREN). These two projects are funded to

Seafloor off Pleasure Point, Santa Cruz County, California

USGS Publications Warehouse

Storlazzi, Curt D.; Golden, Nadine E.; Gibbons, Helen

2013-01-01

The seafloor off Pleasure Point, Santa Cruz County, California, is extremely varied, with sandy flats, boulder fields, faults, and complex bedrock ridges. These ridges support rich marine ecosystems; some of them form the "reefs" that produce world-class surf breaks. Colors indicate seafloor depth, from red-orange (about 2 meters or 7 feet) to magenta (25 meters or 82 feet)

75 FR 1051 - Christian County Generation, LLC; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL10-27-000] Christian County Generation, LLC; Notice of Filing December 30, 2009. Take notice that on December 23, 2009, Christian County Generation, LLC pursuant to section 207 of the Federal Energy Regulatory Commission's (Commission) Rules of Practice and Procedure, 18 CFR...

Comparison of carotenoid accumulation and biosynthetic gene expression between Valencia and Rohde Red Valencia sweet oranges

USDA-ARS?s Scientific Manuscript database

Carotenoid accumulation and biosynthetic gene expression levels during fruit maturation were compared between ordinary Valencia (VAL) and its more deeply colored mutant Rohde Red Valencia orange (RRV). The two cultivars exhibited different carotenoid profiles and regulatory mechanisms in flavedo and...

21 CFR 74.2261 - D&C Orange No. 11.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false D&C Orange No. 11. 74.2261 Section 74.2261 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF... coloring externally applied cosmetics in amounts consistent with good manufacturing practice. (c) Labeling...

21 CFR 74.2260 - D&C Orange No. 10.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false D&C Orange No. 10. 74.2260 Section 74.2260 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF... coloring externally applied cosmetics in amounts consistent with good manufacturing practice. (c) Labeling...

A critical review of the epidemiology of Agent Orange/TCDD and prostate cancer.

PubMed

Chang, Ellen T; Boffetta, Paolo; Adami, Hans-Olov; Cole, Philip; Mandel, Jack S

2014-10-01

To inform risk assessment and regulatory decision-making, the relationship between 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and prostate cancer requires clarification. This article systematically and critically reviews the epidemiologic evidence on the association between exposure to TCDD or Agent Orange, a TCDD-contaminated herbicide used during the Vietnam War, and prostate cancer risk. Articles evaluated include 11 studies of three cohorts, four case-control or cross-sectional studies, and three case-only studies of military veterans with information on estimated Agent Orange or TCDD exposure; 13 studies of seven cohorts, one case-control study, and eight proportionate morbidity or mortality studies of Vietnam veterans without information on Agent Orange exposure; 11 cohort studies of workers with occupational exposure to TCDD; and two studies of one community cohort with environmental exposure to TCDD. The most informative studies, including those of Vietnam veterans involved in Agent Orange spraying or other handling, herbicide manufacturing or spraying workers with occupational TCDD exposure, and community members exposed to TCDD through an industrial accident, consistently reported no significant increase in prostate cancer incidence or mortality. Only some potentially confounded studies of Vietnam veterans compared with the general population, studies with unreliable estimates of Agent Orange exposure, and analyses of selected subgroups of Vietnam veterans reported positive associations. Overall, epidemiologic research offers no consistent or convincing evidence of a causal relationship between exposure to Agent Orange or TCDD and prostate cancer. More accurate exposure assessment is needed in large epidemiologic studies to rule out a causal association more conclusively.

21 CFR 74.2254 - D&C Orange No. 4.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false D&C Orange No. 4. 74.2254 Section 74.2254 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR... coloring externally applied cosmetics in amounts consistent with good manufacturing practice. (c) Labeling...

21 CFR 74.2255 - D&C Orange No. 5.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 5. 74.2255 Section 74.2255 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR... coloring mouthwashes and dentifrices that are ingested cosmetics in amounts consistent with current good...

21 CFR 74.2255 - D&C Orange No. 5.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false D&C Orange No. 5. 74.2255 Section 74.2255 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR... coloring mouthwashes and dentifrices that are ingested cosmetics in amounts consistent with current good...

Regulatory and ethical considerations for linking clinical and administrative databases.

PubMed

Dokholyan, Rachel S; Muhlbaier, Lawrence H; Falletta, John M; Jacobs, Jeffrey P; Shahian, David; Haan, Constance K; Peterson, Eric D

2009-06-01

Clinical data registries are valuable tools that support evidence development, performance assessment, comparative effectiveness studies, and the adoption of new treatments into routine clinical practice. Although these registries do not have important information on long-term therapies or clinical events, administrative claims databases offer a potentially valuable complement. This article focuses on the regulatory and ethical considerations that arise from the use of registry data for research, including linkage of clinical and administrative data sets. (1) Are such activities primarily designed for quality assessment and improvement, research, or both, as this determines the appropriate ethical and regulatory standards? (2) Does the submission of data to a central registry, which may subsequently be linked to other data sources, require review by the institutional review board (IRB) of each participating organization? (3) What levels and mechanisms of IRB oversight are appropriate for the existence of a linked central data repository and the specific studies that may subsequently be developed using it? (4) Under what circumstances are waivers of informed consent and Health Insurance Portability and Accountability Act authorization required? (5) What are the requirements for a limited data set that would qualify a research activity as not involving human subjects and thus not subject to further IRB review? The approaches outlined in this article represent a local interpretation of the regulations in the context of several clinical data registry projects and focuses on a specific case study of the Society of Thoracic Surgeons National Database.

21 CFR 146.148 - Reduced acid frozen concentrated orange juice.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Reduced acid frozen concentrated orange juice. 146.148 Section 146.148 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CANNED FRUIT JUICES Requirements for Specific Standardized...

Geochemical Characteristics of TP3 Mine Wastes at the Elizabeth Copper Mine Superfund Site, Orange County, Vermont

USGS Publications Warehouse

Hammarstrom, Jane M.; Piatak, Nadine M.; Seal, Robert R.; Briggs, Paul H.; Meier, Allen L.; Muzik, Timothy L.

2003-01-01

Remediation of the Elizabeth mine Superfund site in the Vermont copper belt poses challenges for balancing environmental restoration goals with issues of historic preservation while adopting cost-effective strategies for site cleanup and long-term maintenance. The waste-rock pile known as TP3, at the headwaters of Copperas Brook, is especially noteworthy in this regard because it is the worst source of surface- and ground-water contamination identified to date, while also being the area of greatest historical significance. The U.S. Geological Survey (USGS) conducted a study of the historic mine-waste piles known as TP3 at the Elizabeth mine Superfund site near South Strafford, Orange County, VT. TP3 is a 12.3-acre (49,780 m2) subarea of the Elizabeth mine site. It is a focus area for historic preservation because it encompasses an early 19th century copperas works as well as waste from late 19th- and 20th century copper mining (Kierstead, 2001). Surface runoff and seeps from TP3 form the headwaters of Copperas Brook. The stream flows down a valley onto flotation tailings from 20th century copper mining operations and enters the West Branch of the Ompompanoosuc River approximately 1 kilometer downstream from the mine site. Shallow drinking water wells down gradient from TP3 exceed drinking water standards for copper and cadmium (Hathaway and others, 2001). The Elizabeth mine was listed as a Superfund site in 2001, mainly because of impacts of acid-mine drainage on the Ompompanoosuc River.

Regulatory administrative databases in FDA's Center for Biologics Evaluation and Research: convergence toward a unified database.

PubMed

Smith, Jeffrey K

2013-04-01

Regulatory administrative database systems within the Food and Drug Administration's (FDA) Center for Biologics Evaluation and Research (CBER) are essential to supporting its core mission, as a regulatory agency. Such systems are used within FDA to manage information and processes surrounding the processing, review, and tracking of investigational and marketed product submissions. This is an area of increasing interest in the pharmaceutical industry and has been a topic at trade association conferences (Buckley 2012). Such databases in CBER are complex, not for the type or relevance of the data to any particular scientific discipline but because of the variety of regulatory submission types and processes the systems support using the data. Commonalities among different data domains of CBER's regulatory administrative databases are discussed. These commonalities have evolved enough to constitute real database convergence and provide a valuable asset for business process intelligence. Balancing review workload across staff, exploring areas of risk in review capacity, process improvement, and presenting a clear and comprehensive landscape of review obligations are just some of the opportunities of such intelligence. This convergence has been occurring in the presence of usual forces that tend to drive information technology (IT) systems development toward separate stovepipes and data silos. CBER has achieved a significant level of convergence through a gradual process, using a clear goal, agreed upon development practices, and transparency of database objects, rather than through a single, discrete project or IT vendor solution. This approach offers a path forward for FDA systems toward a unified database.

Inheritance of flower color in periwinkle: orange-red corolla and white eye.

PubMed

Sreevalli, Y; Kulkarni, R N; Baskaran, K

2002-01-01

The commonly found flower colors in periwinkle (Catharanthus roseus)--pink, white, red-eyed, and pale pink center--are reported to be governed by the epistatic interaction between four genes--A, R, W, and I. The mode of inheritance of an uncommon flower color, orange-red corolla and white eye, was studied by crossing an accession possessing this corolla color with a white flowered variety (Nirmal). The phenotype of the F(1) plants and segregation data of F(2) and backcross generations suggested the involvement of two more interacting and independently inherited genes, one (proposed symbol E) determining the presence or absence of red eye and another (proposed symbol O) determining orange-red corolla.

The Comprehensive Career Education System: System Administrators Component K-12.

ERIC Educational Resources Information Center

Educational Properties Inc., Irvine, CA.

Using the example of a Career Education Model developed by the Orange County, California Consortium, the document provides guidelines for setting up career education programs in local educational agencies. Component levels, a definition of career education, and Consortium program background are discussed. Subsequent chapters include: Program…

Administrative Satisfaction and the Regulatory Climate at Public Institutions. AIR 1997 Annual Forum Paper.

ERIC Educational Resources Information Center

Volkwein, James Fredericks; Malik, Shaukat M.; Napierski-Prancl, Michelle

This study examined the effects of state regulation of financial, personnel, and academic resources on the administrative flexibility granted to universities, and tested the hypothesis that state regulatory climate influences levels of managerial satisfaction. Data were gathered through two surveys. The first covered management flexibility and…

76 FR 30655 - Certain Orange Juice From Brazil: Final Results of the Expedited Sunset Review of the Antidumping...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-26

... DEPARTMENT OF COMMERCE International Trade Administration [A-351-840] Certain Orange Juice From... Administration, International Trade Administration, Department of Commerce. SUMMARY: On February 1, 2011, the Department of Commerce (the Department) initiated a sunset review of the antidumping duty order on certain...

Distinct functions of neuromedin u and neuromedin s in orange-spotted grouper.

PubMed

Li, Shuisheng; Xiao, Ling; Liu, Qiongyu; Zheng, Binbin; Chen, Huapu; Liu, Xiaochun; Zhang, Yong; Lin, Haoran

2015-10-01

Neuromedin U (NMU) and neuromedin S (NMS) play inhibitory roles in the regulation of food intake and energy homeostasis in mammals. However, their functions are not clearly established in teleost fish. In the present study, nmu and nms homologs were identified in several fish species. Subsequently, their cDNA sequences were cloned from the orange-spotted grouper (Epinephelus coioides). Sequence analysis showed that the orange-spotted grouper Nmu proprotein contains a 21-amino acid mature Nmu peptide (Nmu-21). The Nms proprotein lost the typical mature Nms peptide, but it retains a putative 34-amino acid peptide (Nmsrp). In situ hybridization revealed that nmu- and nms-expressing cells are mainly localized in the hypothalamic regions associated with appetite regulation. Food deprivation decreased the hypothalamic nmu mRNA levels but induced an increase of nms mRNA levels. Periprandial expression analysis showed that hypothalamic expression of nmu increased significantly at 3 h post-feeding, while nms expression was elevated at the normal feeding time. I.p. injection of synthetic Nmu-21 peptide suppressed the hypothalamic neuropeptide y (npy) expression, while Nmsrp administration significantly increased the expression of npy and orexin in orange-spotted grouper. Furthermore, the mRNA levels of LH beta subunit (lhβ) and gh in the pituitary were significantly down-regulated after Nmu-21 peptide administration, while Nmsrp was able to significantly stimulate the expression of FSH beta subunit (fshβ), prolactin (prl), and somatolaction (sl). Our results indicate that nmu and nms possess distinct neuroendocrine functions and pituitary functions in the orange spotted grouper. © 2015 Society for Endocrinology.

Ground-water resources data for Baldwin County, Alabama

USGS Publications Warehouse

Robinson, James L.; Moreland, Richard S.; Clark, Amy E.

1996-01-01

Geologic and hydrologic data for 237 wells were collected, and water-levels in 223 wells in Baldwin and Escambia Counties were measured. Long-term water water-level data, available for many wells, indicate that ground-water levels in most of Baldwin County show no significant trends for the period of record. However, ground-water levels have declined in the general vicinity of Spanish Fort and Daphne, and ground-water levels in the Gulf Shores and Orange Beach areas are less than 5 feet above sea level in places. The quality of ground water generally is good, but problems with iron, sulfur, turbidity, and color occur. The water from most private wells in Baldwin County is used without treatment or filtration. Alabama public- health law requires that water from public-supply wells be chlorinated. Beyond that, the most common treatment of ground water by public-water suppliers in Baldwin County consists of pH adjustment, iron removal, and aeration. The transmissivity of the Miocene-Pliocene aquifer was determined at 10 locations in Baldwin County. Estimates of transmissivity ranged from 700 to 5,400 feet squared per day. In general, aquifer transmissivity was greatest in the southeastern part of the county, and least in the western part of the county near Mobile Bay. A storage coefficient of 1.5 x 10-3 was determined for the Miocene-Pliocene aquifer near Loxley.

Social Diffusion of Water Conservation: A Study of Residential Turf Rebate Programs in Orange County, California

NASA Astrophysics Data System (ADS)

Duong, K.; Grant, S. B.; Rippy, M.; Feldman, D.

2017-12-01

From 2011 to 2017, the combination of record low precipitation and extreme warm temperatures resulted in the most severe drought in California's written history. In April 2015, Governor Jerry Brown issued an executive order mandating a statewide 25% reduction in potable urban water usage. Under such circumstances, outdoor watering is an obvious target for restriction, because it can account for a large fraction of total domestic water usage, up to 50% in the arid southwest [Syme et. al 2004, Cameron et. al 2012]. In this study we analyzed one such effort, in which the Irvine Ranch Water District (IRWD) in Orange County (California) offered a financial incentive through a turf rebate program to encourage Irvine residents to replace turf grass with drought tolerant landscaping. We focused specifically on the number of residents who applied to the turf rebate program. Our hypothesis was that the observed application rate (number of applicants per month) is influenced by a combination of (a) financial incentives issued by IRWD, (b) drought awareness, and (c) the fraction of neighbors that have already applied to the program (a phenomenon that can be described quantitatively through models of social contagion or social diffusion [Karsai et. al 2014]). Our preliminary results indicate that applications to the program occurred in geographic "hot spots", consistent with the idea that early adopters may have influenced neighbors to retrofit their lawns. We are currently evaluating the geographic, demographic, and temporal drivers that influence the rate of spontaneous adoption, the rate of adoption under influence, and the total size of the susceptible population. Overall, our goal is to identify the key factors that contribute to early rapid uptake of conservation behavior, and the rapid diffusion of that behavior through the community.

78 FR 14075 - Certain Orange Juice From Brazil; Notice of Amended Final Results of Antidumping Duty...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-04

... Brazil; Notice of Amended Final Results of Antidumping Duty Administrative Review AGENCY: Import... Final Results On August 11, 2008, the Department of Commerce (the Department) published the final results of its administrative review of the antidumping duty order on certain orange juice (OJ) from...

Growing Oranges. People on the Farm.

ERIC Educational Resources Information Center

Department of Agriculture, Washington, DC. Office of Governmental and Public Affairs.

This booklet, one in a series about life on modern farms, describes the daily lives of three orange growers in Florida and one in California. Two of the Florida orange growers also have other jobs, one as manager of a citrus cooperative and the other as a citrus insurance salesman. The operations of orange groves, the care and picking of oranges,…

Nye County Nevada Perspectives on the State of the Yucca Mountain Project - 12388

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lacy, Darrell; Voegele, Michael; Jaszczak, Casmier

2012-07-01

Responding to the Department of Energy decision to try to withdraw the Yucca Mountain license application and the Administration actions to close down the Yucca Mountain project, Nye County undertook a number of activities to articulate its support for continuing the Yucca Mountain project. The activities included responding to inquiries from federal agencies, including investigations undertaken by the Government Accountability Office addressing other potential uses for the Yucca Mountain site, responding to a Draft Environmental Impact Statement on the possible use of Yucca Mountain for disposal of Greater than Class C wastes, testifying in hearings, and interacting with the President'smore » Blue Ribbon Commission on America's Nuclear Future. The paper summarizes Nye County's position on the Yucca Mountain repository, Nye County's perspectives on the various activities that were developed and considered by the Government Accountability Office, Nye County's concerns with the use of the Nevada National Security Site for Disposal of Greater than Class C Low-Level Radioactive Wastes, testimony of Nye County officials expressing local community support for the Yucca Mountain project, and Nye County's perspectives on recommendations provided by the Blue Ribbon Commission to move the nation's high-level radioactive waste disposal programs forward without consideration of the role Yucca Mountain could have served in those recommendations. Nye County believes that every effort should be made to, at a minimum, fund the Nuclear Regulatory Commission to complete the license application review. Then, if Congress does decide to change the Nuclear Waste Policy Act, there will be valuable information available to support new policy development. This administration contends that Congressional language associated with the FY2010 and FY2011 appropriations and authorization process is sufficient evidence of its intent to terminate the Yucca Mountain repository program. The

75 FR 11225 - Environmental Impact Statement; Lee and Collier Counties, Florida

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-10

... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Environmental Impact Statement; Lee and Collier Counties, Florida AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of...) for the proposed County Road 951 highway project in Lee and Collier Counties, Florida. This is formal...

The diffusion of innovation in nursing regulatory policy: removing a barrier to medication administration training for child care providers.

PubMed

Torre, Carolyn T; Crowley, Angela A

2011-08-01

Safe medication administration is an essential component of high-quality child care. Its achievement in New Jersey was impeded by a controversy over whether teaching child care providers medication administration involves registered nurses in the process of nursing delegation. Through the theoretical framework of the Diffusion of Innovation, this paper examines how the interpretation of regulatory policy related to nursing practice in New Jersey was adjusted by the Board of Nursing following a similar interpretation of regulatory policy by the Board of Nursing in Connecticut. This adjustment enabled New Jersey nurses to continue medication administration training for child care providers. National data supporting the need for training child care providers in medication administration is presented, the Diffusion of Innovation paradigm is described; the Connecticut case and the New Jersey dilemma are discussed; the diffusion process between the two states is analyzed and an assessment of the need for further change is made.

7 CFR 760.1301 - Administration.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Administrator” in this part), and will be carried out by FSA's Price Support Division (PSD) and Kansas City... PSD, KCMO, a State committee, or a county committee will preclude the Administrator, FSA, or a... determination made by PSD, KCMO, a State committee, or a county committee. (f) The Deputy Administrator may...

7 CFR 760.1301 - Administration.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Administrator” in this part), and will be carried out by FSA's Price Support Division (PSD) and Kansas City... PSD, KCMO, a State committee, or a county committee will preclude the Administrator, FSA, or a... determination made by PSD, KCMO, a State committee, or a county committee. (f) The Deputy Administrator may...

7 CFR 760.1301 - Administration.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Administrator” in this part), and will be carried out by FSA's Price Support Division (PSD) and Kansas City... PSD, KCMO, a State committee, or a county committee will preclude the Administrator, FSA, or a... determination made by PSD, KCMO, a State committee, or a county committee. (f) The Deputy Administrator may...

7 CFR 760.1301 - Administration.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Administrator” in this part), and will be carried out by FSA's Price Support Division (PSD) and Kansas City... PSD, KCMO, a State committee, or a county committee will preclude the Administrator, FSA, or a... determination made by PSD, KCMO, a State committee, or a county committee. (f) The Deputy Administrator may...

7 CFR 1220.626 - FSA county office report.

Code of Federal Regulations, 2010 CFR

2010-01-01

... CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.626 FSA county office report. The county FSA office report shall be certified as accurate and complete by the CED or designee... county summary of requests on a form provided by the Administrator, FSA. Each county FSA office shall...

7 CFR 1220.626 - FSA county office report.

Code of Federal Regulations, 2013 CFR

2013-01-01

... CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.626 FSA county office report. The county FSA office report shall be certified as accurate and complete by the CED or designee... county summary of requests on a form provided by the Administrator, FSA. Each county FSA office shall...

7 CFR 1220.626 - FSA county office report.

Code of Federal Regulations, 2014 CFR

2014-01-01

... CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.626 FSA county office report. The county FSA office report shall be certified as accurate and complete by the CED or designee... county summary of requests on a form provided by the Administrator, FSA. Each county FSA office shall...

7 CFR 1220.626 - FSA county office report.

Code of Federal Regulations, 2012 CFR

2012-01-01

... CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.626 FSA county office report. The county FSA office report shall be certified as accurate and complete by the CED or designee... county summary of requests on a form provided by the Administrator, FSA. Each county FSA office shall...

7 CFR 1220.626 - FSA county office report.

Code of Federal Regulations, 2011 CFR

2011-01-01

... CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.626 FSA county office report. The county FSA office report shall be certified as accurate and complete by the CED or designee... county summary of requests on a form provided by the Administrator, FSA. Each county FSA office shall...

Philadelphus L.: mock orange

Treesearch

Nancy L. Shaw; Emerenciana G. Hurd; Peter F. Stickney

2008-01-01

The mock oranges - Philadelphus spp. - have been placed in several families: Saxifragaceae (Harrington 1954), Hydrangeaceae (Hitchcock and others 1961), and more recently, the Philadelphaceae (Hickman 1993). Hydrangeaceae, however, is the most widely accepted placement (Cronquist and others 1997; USDA NRCS 2001). There are about 50 to 65 species of mock orange,...

Hydrogeology and simulation of the effects of reclaimed-water application in west Orange and southeast Lake counties, Florida

USGS Publications Warehouse

O'Reilly, Andrew M.

1998-01-01

Wastewater reclamation and reuse has become increasingly popular as water agencies search for alternative water-supply and wastewater-disposal options. Several governmental agencies in central Florida currently use the land-based application of reclaimed water (wastewater that has been treated beyond secondary treatment) as a management alternative to surface-water disposal of wastewater. Water Conserv II, a water reuse project developed jointly by Orange County and the City of Orlando, began operation in December 1986. In 1995, the Water Conserv II facility distributed approximately 28 Mgal/d of reclaimed water for discharge to rapid-infiltration basins (RIBs) and for use as agricultural irrigation. The Reedy Creek Improvement District (RCID) began operation of RIBs in September 1990, and in 1995 these RIBs received approximately 6.7 Mgal/d of reclaimed water. Analyses of existing data and data collected during the course of this study were combined with ground-water flow modeling and particle-tracking analyses to develop a process-oriented evaluation of the regional effects of reclaimed water applied by Water Conserv II and the RCID RIBs on the hydrology of west Orange and southeast Lake Counties. The ground-water flow system beneath the study area is a multi-aquifer system that consists of a thick sequence of highly permeable carbonate rocks overlain by unconsolidated sediments. The hydrogeologic units are the unconfined surficial aquifer system, the intermediate confining unit, and the confined Floridan aquifer system, which consists of two major permeable zones, the Upper and Lower Floridan aquifers, separated by the less permeable middle semiconfining unit. Flow in the surficial aquifer system is dominated regionally by diffuse downward leakage to the Floridan aquifer system and is affected locally by lateral flow systems produced by streams, lakes, and spatial variations in recharge. Ground water generally flows laterally through the Upper Floridan aquifer

Do Sexually Oriented Massage Parlors Cluster in Specific Neighborhoods? A Spatial Analysis of Indoor Sex Work in Los Angeles and Orange Counties, California

PubMed Central

Kim, Anna J.; Takahashi, Lois; Wiebe, Douglas J.

2015-01-01

Objective Social determinants of health may be substantially affected by spatial factors, which together may explain the persistence of health inequities. Clustering of possible sources of negative health and social outcomes points to a spatial focus for future interventions. We analyzed the spatial clustering of sex work businesses in Southern California to examine where and why they cluster. We explored economic and legal factors as possible explanations of clustering. Methods We manually coded data from a website used by paying members to post reviews of female massage parlor workers. We identified clusters of sexually oriented massage parlor businesses using spatial autocorrelation tests. We conducted spatial regression using census tract data to identify predictors of clustering. Results A total of 889 venues were identified. Clusters of tracts having higher-than-expected numbers of sexually oriented massage parlors (“hot spots”) were located outside downtowns. These hot spots were characterized by a higher proportion of adult males, a higher proportion of households below the federal poverty level, and a smaller average household size. Conclusion Sexually oriented massage parlors in Los Angeles and Orange counties cluster in particular neighborhoods. More research is needed to ascertain the causal factors of such clusters and how interventions can be designed to leverage these spatial factors. PMID:26327731

Do Sexually Oriented Massage Parlors Cluster in Specific Neighborhoods? A Spatial Analysis of Indoor Sex Work in Los Angeles and Orange Counties, California.

PubMed

Chin, John J; Kim, Anna J; Takahashi, Lois; Wiebe, Douglas J

2015-01-01

Social determinants of health may be substantially affected by spatial factors, which together may explain the persistence of health inequities. Clustering of possible sources of negative health and social outcomes points to a spatial focus for future interventions. We analyzed the spatial clustering of sex work businesses in Southern California to examine where and why they cluster. We explored economic and legal factors as possible explanations of clustering. We manually coded data from a website used by paying members to post reviews of female massage parlor workers. We identified clusters of sexually oriented massage parlor businesses using spatial autocorrelation tests. We conducted spatial regression using census tract data to identify predictors of clustering. A total of 889 venues were identified. Clusters of tracts having higher-than-expected numbers of sexually oriented massage parlors ("hot spots") were located outside downtowns. These hot spots were characterized by a higher proportion of adult males, a higher proportion of households below the federal poverty level, and a smaller average household size. Sexually oriented massage parlors in Los Angeles and Orange counties cluster in particular neighborhoods. More research is needed to ascertain the causal factors of such clusters and how interventions can be designed to leverage these spatial factors.

Impacts on State and Local Agencies for Maintaining Traffic Signs within Minimum Retroreflectivity Guidelines

DOT National Transportation Integrated Search

1998-04-01

The Federal Highway Administration (FHWA) has developed guidelines for minimum retroreflectivity levels for four groups of signs: 1) yellow/orange-on-black warning signs, 2) black-on-white regulatory signs, 3) white-on-red regulatory signs, and 4) wh...

Happy orang-utans live longer lives.

PubMed

Weiss, Alexander; Adams, Mark J; King, James E

2011-12-23

Nonhuman primate ageing resembles its human counterpart. Moreover, ratings of subjective well-being traits in chimpanzees, orang-utans and rhesus macaques are similar to those of humans: they are intercorrelated, heritable, and phenotypically and genetically related to personality. We examined whether, as in humans, orang-utan subjective well-being was related to longer life. The sample included 184 zoo-housed orang-utans followed up for approximately 7 years. Age, sex, species and number of transfers were available for all subjects and 172 subjects were rated on at least one item of a subjective well-being scale. Of the 31 orang-utans that died, 25 died a mean of 3.4 years after being rated. Even in a model that included, and therefore, statistically adjusted for, sex, age, species and transfers, orang-utans rated as being "happier" lived longer. The risk differential between orang-utans that were one standard deviation above and one standard deviation below baseline in subjective well-being was comparable with approximately 11 years in age. This finding suggests that impressions of the subjective well-being of captive great apes are valid indicators of their welfare and longevity.

Epidemiology and the economic assessment of a mumps outbreak in a highly vaccinated population, Orange County, New York, 2009-2010.

PubMed

Kutty, Preeta Krishnan; Lawler, Jacqueline; Rausch-Phung, Elizabeth; Ortega-Sanchez, Ismael R; Goodell, Stephen; Schulte, Cynthia; Pollock, Lynn; Valure, Barbara; Hudson, Jean; Gallagher, Kathleen; Blog, Debra

2014-01-01

Studies assessing the economic burden of a mumps outbreak in a highly vaccinated population are limited. The Orange County Health Department (OCHD), New York State Department of Health (NYS DOH), and the Centers for Disease Control and Prevention conducted a mumps investigation in an affected village with a highly vaccinated population. To understand the epidemiology, standardized mumps case definition and active surveillance were used to identify mumps cases. In addition, an economic assessment of a combined outbreak investigation and third dose measles-mumps-rubella (MMR) vaccine intervention conducted by OCHD and NYS DOH was performed; estimated by retrospectively evaluating public health response-related activities including use of a third dose of MMR vaccine. From September 24, 2009, through June 15, 2010, 790 mumps cases were reported-64% were male and highest attack rate was among 11-17 year age group (99.1 cases per 1000 individuals). Of the 658 cases with known vaccination history, 83.6% had documentation of 2 doses of mumps containing vaccine. No deaths were reported. The 2 major exposure settings were schools (71.8%) and households (22.5%). Approximately 7736 h of public health personnel time were expended with the total approximate cost of US $463,000, including US $34,392 for MMR vaccine-the estimated cost per household was US $827. Mumps continues to be endemic in many parts of the world, resulting in importations into the United States. Large mumps outbreaks similar to this in highly vaccinated populations may require considerable investigation and control activities.

21 CFR 146.145 - Orange juice from concentrate.

Code of Federal Regulations, 2011 CFR

2011-04-01

... sweetening ingredients referred to in paragraph (a) of this section are sugar, sugar sirup, invert sugar... Juices and Beverages § 146.145 Orange juice from concentrate. (a) Orange juice from concentrate is the...), orange oil, orange pulp, and one or more of the sweetening ingredients listed in paragraph (b) of this...

21 CFR 146.145 - Orange juice from concentrate.

Code of Federal Regulations, 2010 CFR

2010-04-01

... sweetening ingredients referred to in paragraph (a) of this section are sugar, sugar sirup, invert sugar... Juices and Beverages § 146.145 Orange juice from concentrate. (a) Orange juice from concentrate is the...), orange oil, orange pulp, and one or more of the sweetening ingredients listed in paragraph (b) of this...

21 CFR 146.145 - Orange juice from concentrate.

Code of Federal Regulations, 2012 CFR

2012-04-01

... sweetening ingredients referred to in paragraph (a) of this section are sugar, sugar sirup, invert sugar... Juices and Beverages § 146.145 Orange juice from concentrate. (a) Orange juice from concentrate is the...), orange oil, orange pulp, and one or more of the sweetening ingredients listed in paragraph (b) of this...

21 CFR 146.145 - Orange juice from concentrate.

Code of Federal Regulations, 2013 CFR

2013-04-01

... sweetening ingredients referred to in paragraph (a) of this section are sugar, sugar sirup, invert sugar... Juices and Beverages § 146.145 Orange juice from concentrate. (a) Orange juice from concentrate is the...), orange oil, orange pulp, and one or more of the sweetening ingredients listed in paragraph (b) of this...

21 CFR 146.145 - Orange juice from concentrate.

Code of Federal Regulations, 2014 CFR

2014-04-01

... sweetening ingredients referred to in paragraph (a) of this section are sugar, sugar sirup, invert sugar... Juices and Beverages § 146.145 Orange juice from concentrate. (a) Orange juice from concentrate is the...), orange oil, orange pulp, and one or more of the sweetening ingredients listed in paragraph (b) of this...

Orange Button Solar Data Exchange | Energy Analysis | NREL

Science.gov Websites

Orange Button Solar Data Exchange Orange Button Solar Data Exchange The new Orange Button Solar Data Exchange tool serves as an online resource for the solar industry to share, sell, or retrieve solar data and connect with colleagues. Screenshot image of Orange Button data website home page. The

78 FR 60009 - Environmental Impact Statement: Erie and Genesee Counties, New York

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-30

... and Genesee Counties, New York AGENCY: Federal Highway Administration (FHWA), DOT; New York State... counties of Erie and Genesee, New York (NYSDOT Project Identification Number: 5528.28). A Notice of Intent... CONTACT: Jonathan McDade, Division Administrator, Federal Highway Administration, New York Division, Leo W...

21 CFR 146.140 - Pasteurized orange juice.

Code of Federal Regulations, 2010 CFR

2010-04-01

... and Beverages § 146.140 Pasteurized orange juice. (a) Pasteurized orange juice is the food prepared... section. One or more of the optional sweetening ingredients listed in paragraph (c) of this section may be... orange juice soluble solids, exclusive of the solids of any added optional sweetening ingredients, and...

21 CFR 146.140 - Pasteurized orange juice.

Code of Federal Regulations, 2012 CFR

2012-04-01

... and Beverages § 146.140 Pasteurized orange juice. (a) Pasteurized orange juice is the food prepared... section. One or more of the optional sweetening ingredients listed in paragraph (c) of this section may be... orange juice soluble solids, exclusive of the solids of any added optional sweetening ingredients, and...

21 CFR 146.140 - Pasteurized orange juice.

Code of Federal Regulations, 2014 CFR

2014-04-01

... and Beverages § 146.140 Pasteurized orange juice. (a) Pasteurized orange juice is the food prepared... section. One or more of the optional sweetening ingredients listed in paragraph (c) of this section may be... orange juice soluble solids, exclusive of the solids of any added optional sweetening ingredients, and...

21 CFR 146.140 - Pasteurized orange juice.

Code of Federal Regulations, 2011 CFR

2011-04-01

... and Beverages § 146.140 Pasteurized orange juice. (a) Pasteurized orange juice is the food prepared... section. One or more of the optional sweetening ingredients listed in paragraph (c) of this section may be... orange juice soluble solids, exclusive of the solids of any added optional sweetening ingredients, and...

21 CFR 146.140 - Pasteurized orange juice.

Code of Federal Regulations, 2013 CFR

2013-04-01

... and Beverages § 146.140 Pasteurized orange juice. (a) Pasteurized orange juice is the food prepared... section. One or more of the optional sweetening ingredients listed in paragraph (c) of this section may be... orange juice soluble solids, exclusive of the solids of any added optional sweetening ingredients, and...

A Comparison of the Perceptions of School Work Culture by Administrators and Faculty in the Public Charter and Non-Charter Elementary Schools of a Central Florida County

ERIC Educational Resources Information Center

Quin, Wayne Anthony

2012-01-01

This study investigated perceptions of school work culture of instructional staff members (administrators and faculty) in public charter and public non-charter elementary schools in a large urban metropolitan county of Central Florida by assessing differences in perceptions of administrators and faculty related to school work culture, perceptions…

75 FR 18245 - Public Federal Regulatory Enforcement Fairness Hearing Region IX Regulatory Fairness Board

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-09

... the meeting is for Business Organizations, Trade Associations, Chambers of Commerce and related... SMALL BUSINESS ADMINISTRATION Public Federal Regulatory Enforcement Fairness Hearing Region IX... hereby given that the U.S. Small Business Administration (SBA) Region IX Regulatory Fairness Board and...

Advancing regulatory science to bring novel medical devices for use in emergency care to market: the role of the Food and Drug Administration.

PubMed

Scully, Christopher G; Forrest, Shawn; Galeotti, Loriano; Schwartz, Suzanne B; Strauss, David G

2015-04-01

The Food and Drug Administration (FDA) performs regulatory science to provide science-based medical product regulatory decisions. This article describes the types of scientific research the FDA's Center for Devices and Radiological Health performs and highlights specific projects related to medical devices for emergency medicine. In addition, this article discusses how results from regulatory science are used by the FDA to support the regulatory process as well as how the results are communicated to the public. Regulatory science supports the FDA's mission to assure safe, effective, and high-quality medical products are available to patients. Published by Elsevier Inc.

21 CFR 146.141 - Canned orange juice.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Beverages § 146.141 Canned orange juice. (a) Canned orange juice is the food prepared from orange juice as... the deoiling operation may be added back. One or more of the optional sweetening ingredients named in... milliliters of juice is not less than 9 to 1. (b) The optional sweetening ingredients referred to in paragraph...

21 CFR 146.141 - Canned orange juice.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Beverages § 146.141 Canned orange juice. (a) Canned orange juice is the food prepared from orange juice as... the deoiling operation may be added back. One or more of the optional sweetening ingredients named in... milliliters of juice is not less than 9 to 1. (b) The optional sweetening ingredients referred to in paragraph...

21 CFR 146.141 - Canned orange juice.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Beverages § 146.141 Canned orange juice. (a) Canned orange juice is the food prepared from orange juice as... the deoiling operation may be added back. One or more of the optional sweetening ingredients named in... milliliters of juice is not less than 9 to 1. (b) The optional sweetening ingredients referred to in paragraph...

21 CFR 146.141 - Canned orange juice.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Beverages § 146.141 Canned orange juice. (a) Canned orange juice is the food prepared from orange juice as... the deoiling operation may be added back. One or more of the optional sweetening ingredients named in... milliliters of juice is not less than 9 to 1. (b) The optional sweetening ingredients referred to in paragraph...

21 CFR 146.141 - Canned orange juice.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Beverages § 146.141 Canned orange juice. (a) Canned orange juice is the food prepared from orange juice as... the deoiling operation may be added back. One or more of the optional sweetening ingredients named in... milliliters of juice is not less than 9 to 1. (b) The optional sweetening ingredients referred to in paragraph...

78 FR 30384 - Federal Regulatory Enforcement Fairness Hearing; Region X Regulatory Fairness Board

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-22

... SMALL BUSINESS ADMINISTRATION Federal Regulatory Enforcement Fairness Hearing; Region X Regulatory... Regional (Region X) Small Business Regulatory Fairness Board. SUMMARY: The (SBA) Office of the National... Region X Regulatory Fairness Board must contact Jos[eacute] M[eacute]ndez by May 30, 2013 in writing, by...

76 FR 3825 - Regulatory Compliance

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-21

... Compliance Memorandum for the Heads of Executive Departments and Agencies My Administration is committed to... regulatory compliance and enforcement activities, such as information with respect to administrative... compliance information fosters fair and consistent enforcement of important regulatory obligations. Such...

78 FR 27215 - Baker County Oregon; Notice of Application Tendered for Filing With the Commission and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-09

... the base of Mason dam in the vicinity of the exiting discharge via the project's tailrace. Baker... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 12686-004] Baker County...: Baker County, Oregon (Baker County). e. Name of Project: Mason Dam Hydroelectric Project. f. Location...

Epidemiology and the economic assessment of a mumps outbreak in a highly vaccinated population, Orange County, New York, 2009–2010

PubMed Central

Kutty, Preeta Krishnan; Lawler, Jacqueline; Rausch-Phung, Elizabeth; Ortega-Sanchez, Ismael R; Goodell, Stephen; Schulte, Cynthia; Pollock, Lynn; Valure, Barbara; Hudson, Jean; Gallagher, Kathleen; Blog, Debra

2014-01-01

Studies assessing the economic burden of a mumps outbreak in a highly vaccinated population are limited. The Orange County Health Department (OCHD), New York State Department of Health (NYS DOH), and the Centers for Disease Control and Prevention conducted a mumps investigation in an affected village with a highly vaccinated population. To understand the epidemiology, standardized mumps case definition and active surveillance were used to identify mumps cases. In addition, an economic assessment of a combined outbreak investigation and third dose measles-mumps-rubella (MMR) vaccine intervention conducted by OCHD and NYS DOH was performed; estimated by retrospectively evaluating public health response-related activities including use of a third dose of MMR vaccine. From September 24, 2009, through June 15, 2010, 790 mumps cases were reported—64% were male and highest attack rate was among 11–17 year age group (99.1 cases per 1000 individuals). Of the 658 cases with known vaccination history, 83.6% had documentation of 2 doses of mumps containing vaccine. No deaths were reported. The 2 major exposure settings were schools (71.8%) and households (22.5%). Approximately 7736 h of public health personnel time were expended with the total approximate cost of US $463 000, including US $34 392 for MMR vaccine—the estimated cost per household was US $827. Mumps continues to be endemic in many parts of the world, resulting in importations into the United States. Large mumps outbreaks similar to this in highly vaccinated populations may require considerable investigation and control activities. PMID:24633360

The Autism Spectrum Disorders Stem Cell Resource at Children's Hospital of Orange County: Implications for Disease Modeling and Drug Discovery.

PubMed

Brick, David J; Nethercott, Hubert E; Montesano, Samantha; Banuelos, Maria G; Stover, Alexander E; Schutte, Soleil Sun; O'Dowd, Diane K; Hagerman, Randi J; Ono, Michele; Hessl, David R; Tassone, Flora; Schwartz, Philip H

2014-11-01

The autism spectrum disorders (ASDs) comprise a set of neurodevelopmental disorders that are, at best, poorly understood but are the fastest growing developmental disorders in the United States. Because animal models of polygenic disorders such as the ASDs are difficult to validate, the derivation of induced pluripotent stem cells (iPSCs) by somatic cell reprogramming offers an alternative strategy for identifying the cellular mechanisms contributing to ASDs and the development of new treatment options. Access to statistically relevant numbers of ASD patient cell lines, however, is still a limiting factor for the field. We describe a new resource with more than 200 cell lines (fibroblasts, iPSC clones, neural stem cells, glia) from unaffected volunteers and patients with a wide range of clinical ASD diagnoses, including fragile X syndrome. We have shown that both normal and ASD-specific iPSCs can be differentiated toward a neural stem cell phenotype and terminally differentiated into action-potential firing neurons and glia. The ability to evaluate and compare data from a number of different cell lines will facilitate greater insight into the cause or causes and biology of the ASDs and will be extremely useful for uncovering new therapeutic and diagnostic targets. Some drug treatments have already shown promise in reversing the neurobiological abnormalities in iPSC-based models of ASD-associated diseases. The ASD Stem Cell Resource at the Children's Hospital of Orange County will continue expanding its collection and make all lines available on request with the goal of advancing the use of ASD patient cells as disease models by the scientific community. ©AlphaMed Press.

Mercer County (N.J.) Coordination/Consolidation Demonstration Program

DOT National Transportation Integrated Search

1982-03-01

From November 1977 through June 1981, Mercer County in New Jersey, was the site of an Urban Mass Transportation Administration Service and Methods Demonstration, which coordinated human service agency transportation programs. The Mercer County Coordi...

Inheritance of resistance to orange rust in sugarcane

USDA-ARS?s Scientific Manuscript database

Orange rust, caused by Puccinia kuehnii, is an economically important disease in the Florida sugarcane industry. In this study, orange rust reactions of seedlings in progenies originating from 12 crosses between female and male parents with differing resistance to orange rust (three of each categor...

Inheritance of resistance to orange rust in sugarcane

USDA-ARS?s Scientific Manuscript database

Orange rust, caused by Puccinia kuehnii, is an economically important disease in the Florida sugarcane industry. In this study, orange rust reactions of seedlings in progenies originating from 12 crosses between female and male parents with differing resistance to orange rust (three of each category...

75 FR 54620 - Greenwood County, SC; Notice of Availability of Environmental Assessment

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 1267-089] Greenwood County... National Environmental Policy Act of 1969 and the Federal Energy Regulatory Commission's regulations, 18 CFR part 380 (Order No. 486, 52 FR 47879), the Office of Energy Projects has prepared an environmental...

The US Food and Drug Administration's expedited approval programs: Evidentiary standards, regulatory trade-offs, and potential improvements.

PubMed

Wallach, Joshua D; Ross, Joseph S; Naci, Huseyin

2018-06-01

The US Food and Drug Administration has several regulatory programs and pathways to expedite the development and approval of therapeutic agents aimed at treating serious or life-debilitating conditions. A common feature of these programs is the regulatory flexibility, which allows for a customized approval approach that enables market authorization on the basis of less rigorous evidence, in exchange for requiring postmarket evidence generation. An increasing share of therapeutic agents approved by the Food and Drug Administration in recent years are associated with expedited programs. In this article, we provide an overview of the evidentiary standards required by the Food and Drug Administration's expedited development and review programs, summarize the findings of the recent academic literature demonstrating some of the limitations of these programs, and outline potential opportunities to address these limitations. Recent evidence suggests that therapeutic agents in the Food and Drug Administration's expedited programs are approved on the basis of fewer and smaller studies that may lack comparator groups and random allocation, and rather than focusing on clinical outcomes for study endpoints, rely instead on surrogate markers of disease. Once on the market, agents receiving expedited approvals are often quickly incorporated into clinical practice, and evidence generated in the postmarket period may not necessarily address the evidentiary limitations at the time of market entry. Furthermore, not all pathways require additional postmarket studies. Evidence suggests that drugs in expedited approval programs are associated with a greater likelihood that the Food and Drug Administration will take a safety action following market entry. There are several opportunities to improve the timeliness, information value, and validity of the pre- and postmarket studies of therapeutic agents receiving expedited approvals. When use of nonrandomized and uncontrolled studies cannot

Emergency Assessment of Debris-Flow Hazards from Basins Burned by the 2007 Santiago Fire, Orange County, Southern California

USGS Publications Warehouse

Cannon, Susan H.; Gartner, Joseph E.; Michael, John A.; Bauer, Mark A.; Stitt, Susan C.; Knifong, Donna L.; McNamara, Bernard J.; Roque, Yvonne M.

2007-01-01

INTRODUCTION The objective of this report is to present a preliminary emergency assessment of the potential for debris-flow generation from basins burned by the Santiago Fire in Orange County, southern California in 2007. Debris flows are among the most hazardous geologic phenomena; debris flows that followed wildfires in southern California in 2003 killed 16 people and caused tens of millions of dollars of property damage. A short period of even moderate rainfall on a burned watershed can lead to debris flows. Rainfall that is normally absorbed into hillslope soils can run off almost instantly after vegetation has been removed by wildfire. This causes much greater and more rapid runoff than is normal from creeks and drainage areas. Highly erodible soils in a burn scar allow flood waters to entrain large amounts of ash, mud, boulders, and unburned vegetation. Within the burned area and downstream, the force of rushing water, soil, and rock can destroy culverts, bridges, roadways, and buildings, potentially causing injury or death. This emergency debris-flow hazard assessment is presented as relative ranking of the predicted median volume of debris flows that can issue from basin outlets in response to 1.75 inches (44.45 mm) of rainfall over a 3-hour period. Such a storm has a 10-year return period. The calculation of debris flow volume is based on a multiple-regression statistical model that describes the median volume of material that can be expected from a recently burned basin as a function of the area burned at high and moderate severity, the basin area with slopes greater than or equal to 30 percent, and triggering storm rainfall. Cannon and others (2007) describe the methods used to generate the hazard maps. Identification of potential debris-flow hazards from burned drainage basins is necessary to issue warnings for specific basins, to make effective mitigation decisions, and to help plan evacuation timing and routes.

Photoconversion in orange and red fluorescent proteins

PubMed Central

Kremers, Gert-Jan; Hazelwood, Kristin L.; Murphy, Christopher S.; Davidson, Michael W.; Piston, David W.

2009-01-01

We report that photoconversion is fairly common among orange and red fluorescent proteins, as a screen of 12 variants yielded 8 that exhibit photoconversion. Specifically, three red fluorescent proteins can be switched into a green state, and two orange variants can be photoconverted to the far red. The orange highlighters are ideal for dual-probe highlighter applications, and they exhibit the most red-shifted excitation of all fluorescent protein described to date. PMID:19363494

An inventory of ambulance service regulatory programs in California.

PubMed

Narad, R A

1998-01-01

Ambulance regulation in California is the responsibility of numerous agencies on the state and local levels. By identifying and analyzing the variety of programs used in one state, this study establishes a framework for evaluation of state and local regulatory programs elsewhere. This study surveyed all California local EMS agencies (LEMSAs: California's equivalent of regional EMS organizations) to identify the types of regulatory programs used, the foci of these programs (e.g., equipment and personnel), and their application (e.g., public and private providers). All data acquired were analyzed using population parameters rather than inferential statistics. A response rate of 100% was obtained. Among the regulatory tools used are ordinances, contracts, and franchises. Regulatory standards vary widely as do their applications. Large counties and those that operate their own LEMSA have more extensive regulatory programs than do smaller counties and those who participate in multicounty agencies. Many of the enforcement mechanisms available are weak. This study suggests several policy implications for California and other states. The wide variation in the types of regulatory programs and the standards that are used suggest that the purpose and impact of regulatory programs should be studied further. The decentralization of the ambulance regulatory program and the lack of integration of ambulance regulations into EMS system planning also raise policy questions. In addition, the role of multicounty EMS agencies, as it relates to regulation of ambulance services, should be reviewed.

Comparison of carotenoid accumulation and biosynthetic gene expression between Valencia and Rohde Red Valencia sweet oranges.

PubMed

Wei, Xu; Chen, Chunxian; Yu, Qibin; Gady, Antoine; Yu, Yuan; Liang, Guolu; Gmitter, Frederick G

2014-10-01

Carotenoid accumulation and biosynthetic gene expression levels during fruit maturation were compared between ordinary Valencia (VAL) and its more deeply colored mutant Rohde Red Valencia orange (RRV). The two cultivars exhibited different carotenoid profiles and regulatory mechanisms in flavedo and juice sacs, respectively. In flavedo, there was uncoordinated carotenoid accumulation and gene expression in RRV during green stages, which might be related to the expression of certain gene(s) in the MEP (methylerythritol phosphate) pathway. The carotenoid biosynthesis pathway shifting from α,β-xanthophylls to β,β-xanthophylls synthesis occurred in RRV earlier than VAL during orange stages. In juice sacs, the low carotenoid content in both cultivars coincided with low expression of LCYE-Contig03 and LCYE-Contig24 during green stages, suggesting LCYE might be a limiting step for carotenoid accumulation. VAL mainly accumulated violaxanthin, but RRV accumulated β-cryptoxanthin and violaxanthin during orange stages, which corresponded to differences in juice color. Several upstream genes (PDS-Contig17, LCYB-Contig19, and ZDS members) and a downstream gene (ZEP) were expressed at higher levels in RRV than VAL, which might be responsible for greater accumulation of β-cryptoxanthin and violaxanthin in RRV, respectively. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Urinary excretion of Citrus flavanones and their major catabolites after consumption of fresh oranges and pasteurized orange juice: A randomized cross-over study.

PubMed

Aschoff, Julian K; Riedl, Ken M; Cooperstone, Jessica L; Högel, Josef; Bosy-Westphal, Anja; Schwartz, Steven J; Carle, Reinhold; Schweiggert, Ralf M

2016-12-01

Orange juice contains flavanones including hesperidin and narirutin, albeit at lower concentrations as compared to orange fruit. Therefore, we compared bioavailability and colonic catabolism of flavanones from orange juice to a 2.4-fold higher dose from fresh oranges. Following a randomized two-way cross-over design, 12 healthy subjects consumed a test meal comprising either fresh oranges or pasteurized orange juice, delivering 1774 and 751 μmol of total Citrus flavanones, respectively. Deglucuronidated and desulfated hesperetin, naringenin, and the flavanone catabolites 3-(3'-hydroxy-4'-methoxyphenyl)propionic acid, 3-(3'-hydroxyphenyl)hydracrylic acid, 4-hydroxyhippuric acid, and hippuric acid were quantitated in 24-h urine by UHPLC-MS/MS. Differences in urinary hesperetin excretion were found to be nonsignificant (p = 0.5209) both after consumption of orange fruit (21.6 ± 8.0 μmol) and juice (18.3 ± 7.2 μmol). By analogy, postprandial flavanone catabolite excretions were highly similar between treatments. Excretion of 3-(3'-hydroxy-4'-methoxyphenyl)propionic acid was inversely related to that of hesperetin, illustrating the catabolite/precursor relationship. Despite 2.4-fold higher doses, excretion of flavanones from ingested fresh orange fruit did not differ from that following orange juice consumption, possibly due to a saturation of absorption or their entrapment in the fiber-rich matrix of the fruit. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

21 CFR 146.150 - Canned concentrated orange juice.

Code of Federal Regulations, 2014 CFR

2014-04-01

... dilution ratio greater than 3 plus 1 is “Canned concentrated orange juice, ___ plus 1” or “Canned orange juice concentrate, ___ plus 1”, the blank being filled in with the whole number showing the dilution ratio; for example, “Canned orange juice concentrate, 4 plus 1”. However, where the label bears...

21 CFR 146.150 - Canned concentrated orange juice.

Code of Federal Regulations, 2010 CFR

2010-04-01

... dilution ratio greater than 3 plus 1 is “Canned concentrated orange juice, ___ plus 1” or “Canned orange juice concentrate, ___ plus 1”, the blank being filled in with the whole number showing the dilution ratio; for example, “Canned orange juice concentrate, 4 plus 1”. However, where the label bears...

21 CFR 146.150 - Canned concentrated orange juice.

Code of Federal Regulations, 2013 CFR

2013-04-01

... dilution ratio greater than 3 plus 1 is “Canned concentrated orange juice, ___ plus 1” or “Canned orange juice concentrate, ___ plus 1”, the blank being filled in with the whole number showing the dilution ratio; for example, “Canned orange juice concentrate, 4 plus 1”. However, where the label bears...

21 CFR 146.150 - Canned concentrated orange juice.

Code of Federal Regulations, 2011 CFR

2011-04-01

... dilution ratio greater than 3 plus 1 is “Canned concentrated orange juice, ___ plus 1” or “Canned orange juice concentrate, ___ plus 1”, the blank being filled in with the whole number showing the dilution ratio; for example, “Canned orange juice concentrate, 4 plus 1”. However, where the label bears...

21 CFR 146.150 - Canned concentrated orange juice.

Code of Federal Regulations, 2012 CFR

2012-04-01

... dilution ratio greater than 3 plus 1 is “Canned concentrated orange juice, ___ plus 1” or “Canned orange juice concentrate, ___ plus 1”, the blank being filled in with the whole number showing the dilution ratio; for example, “Canned orange juice concentrate, 4 plus 1”. However, where the label bears...

Effect of chlorine dioxide gas on Salmonella enterica inoculated on navel orange surfaces and its impact on the quality attributes of treated oranges.

PubMed

Bhagat, Arpan; Mahmoud, Barakat S M; Linton, Richard H

2011-01-01

Microorganisms, including pathogens of public health significance, have been shown to contaminate orange juice during the mechanical extraction of juice. The problem gets exacerbated when washed oranges have high initial microbial load, due to an insufficient postharvest treatment. The objective of this study was to investigate the reduction of Salmonella enterica on orange surfaces using ClO₂ gas treatments to achieve a 5 log reduction, consistent with the recommendations of the U.S. Department of Agriculture-National Advisory Committee on Microbiological Criteria for Foods. A mixed culture of four Salmonella strains, isolated from previous orange juice outbreaks, was spot inoculated onto orange skin surface areas. The oranges were then treated with 0.1, 0.3, and 0.5 mg/L ClO₂ gas for 2-14 minutes at 22°C and 90%-95% relative humidity. Surviving bacteria on treated areas were recovered and enumerated over treatment time on a nonselective medium, tryptic soy agar, followed by culturing onto a selective medium, xylose lysine deoxycholate agar. A >5 log reduction of Salmonella per sample of orange surface was observed with 0.1 and 0.3 mg/L ClO₂ gas treatments at 14 minutes and a similar log reduction was observed at 0.5 mg/L ClO₂ gas at 10 minutes. This result demonstrates that the treatment of oranges with ClO₂ gas is a promising technology that could be successfully employed for the treatment of whole oranges to reduce the risk of Salmonella outbreaks in orange juice.

The Autism Spectrum Disorders Stem Cell Resource at Children’s Hospital of Orange County: Implications for Disease Modeling and Drug Discovery

PubMed Central

Brick, David J.; Nethercott, Hubert E.; Montesano, Samantha; Banuelos, Maria G.; Stover, Alexander E.; Schutte, Soleil Sun; O’Dowd, Diane K.; Hagerman, Randi J.; Ono, Michele; Hessl, David R.; Tassone, Flora

2014-01-01

The autism spectrum disorders (ASDs) comprise a set of neurodevelopmental disorders that are, at best, poorly understood but are the fastest growing developmental disorders in the United States. Because animal models of polygenic disorders such as the ASDs are difficult to validate, the derivation of induced pluripotent stem cells (iPSCs) by somatic cell reprogramming offers an alternative strategy for identifying the cellular mechanisms contributing to ASDs and the development of new treatment options. Access to statistically relevant numbers of ASD patient cell lines, however, is still a limiting factor for the field. We describe a new resource with more than 200 cell lines (fibroblasts, iPSC clones, neural stem cells, glia) from unaffected volunteers and patients with a wide range of clinical ASD diagnoses, including fragile X syndrome. We have shown that both normal and ASD-specific iPSCs can be differentiated toward a neural stem cell phenotype and terminally differentiated into action-potential firing neurons and glia. The ability to evaluate and compare data from a number of different cell lines will facilitate greater insight into the cause or causes and biology of the ASDs and will be extremely useful for uncovering new therapeutic and diagnostic targets. Some drug treatments have already shown promise in reversing the neurobiological abnormalities in iPSC-based models of ASD-associated diseases. The ASD Stem Cell Resource at the Children’s Hospital of Orange County will continue expanding its collection and make all lines available on request with the goal of advancing the use of ASD patient cells as disease models by the scientific community. PMID:25273538

5 CFR 880.102 - Regulatory structure.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Regulatory structure. 880.102 Section 880.102 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS... Regulatory structure. (a) This part contains the following subparts: (1) Subpart A contains general...

7 CFR 29.1043 - Orange (F).

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Orange (F). 29.1043 Section 29.1043 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1043 Orange (F). A reddish yellow. [42 FR 21092, Apr. 25, 1977. Redesignated at 47 FR...

EPA Announces the Availability of the Removal Administrative Record for the American Drum and Pallet Site in Memphis, Shelby County, Tennessee, the Daily News - Memphis, TN

EPA Pesticide Factsheets

Contains proof of publication of announcement of availability of the removal administrative record for the American Drum and Pallet Site in Memphis, Shelby County, Tennessee, in the Daily News newspaper Region ID: 04 DocID: 10547927, DocDate: 12-24-2007

Technical and Regulatory Guidance for In Situ Chemical Oxidation of Contaminated Soil and Groundwater

DTIC Science & Technology

2001-06-01

B12 6. Former Wood Treatment Facility, Sonoma County , CA . . . . . . . . . . . . . . . . . . . . . B12 7. San Francisco Bay Sites, CA...aromatic hydrocarbons (PAHs) to below regulatory limits. Site: Former Wood Treatment Facility, Sonoma County , CA Technology: Ozone Summary: An array...manufacturing facility, located in Sonoma County , California (Clayton, 2000b). Primary contaminants are pentachlorophenol (PCP) and creosote (i.e., polycyclic

5 CFR 847.102 - Regulatory structure.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Regulatory structure. 847.102 Section 847.102 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS... INSTRUMENTALITIES General Provisions § 847.102 Regulatory structure. (a)(1) Subpart A of this part contains...

Shelter and remotely sensed night temperatures in orange groves

NASA Astrophysics Data System (ADS)

Caselles, V.; Sobrino, J. A.

1991-06-01

In previous papers we have used a linear regression approach for determining nocturnal air temperature in orange groves from satellite thermal data. However, this procedure has a poor precision (≈ 2 °C) for applications such as frost forecasting. For this reason a theoretical method has been proposed, which is based on the following assumptions: (1) the air temperature ( T a) is the result of the convective heat exchange between ground and air, and between air and orange trees, and (2) the remotely-sensed temperature ( T) can be expressed as a function of ground ( T g) and orange tree ( T s) temperatures. So the relationship T = T a + ( a g - α) ( T g - Ts) has been derived, where a = (1 + h 2πR/h1L)-1 and α g = ( ɛ g/ɛ) [ P g + (1 - ɛ 0) G'P s]; h 1 is the convective heat transfer coefficient between ground and air, h 2 is the convective heat transfer coefficient between air and orange tree, R is the orange tree radius, L is the distance between two orange tree trunks, ɛ g and ɛ 0 are the emissivities of the ground and of the orange tree, ɛ is the effective emissivity, P g and P s are the proportions of ground and side of the orange tree observed by the sensor, and G' is the shape factor ground-side. Two experiments were carried out in order to validate this model, in which air temperature was measured by means of a mercury thermometer positioned at 1.5m above the ground and in the middle of two orange tree rows. The temperature of the orange tree and the ground was measured with a radiometer, and the temperature of the orange grove was obtained by means of a manual scanning system. Ground and orange tree emissivities were measured using the box method. We have analyzed the dependence of the T-T a relationship on weather conditions, field architecture and viewing angle, and we can conclude that if these parameters are known, the shelter temperature can be obtained from satellite thermal data with a precision of 0.8 °C.

Golden eagle (Aquila chrysaetos) habitat selection as a function of land use and terrain, San Diego County, California

USGS Publications Warehouse

Tracey, Jeff A.; Madden, Melanie C.; Bloom, Peter H.; Katzner, Todd E.; Fisher, Robert N.

2018-04-16

Beginning in 2014, the U.S. Geological Survey, in collaboration with Bloom Biological, Inc., began telemetry research on golden eagles (Aquila chrysaetos) captured in the San Diego, Orange, and western Riverside Counties of southern California. This work was supported by the San Diego Association of Governments, California Department of Fish and Wildlife, the U.S. Fish and Wildlife Service, the Bureau of Land Management, and the U.S. Geological Survey. Since 2014, we have tracked more than 40 eagles, although this report focuses only on San Diego County eagles.An important objective of this research is to develop habitat selection models for golden eagles. Here we provide predictions of population-level habitat selection for golden eagles in San Diego County based on environmental covariates related to land use and terrain.

Identification and Characterization of Citrus tristeza virus Isolates Breaking Resistance in Trifoliate Orange in California.

PubMed

Yokomi, Raymond K; Selvaraj, Vijayanandraj; Maheshwari, Yogita; Saponari, Maria; Giampetruzzi, Annalisa; Chiumenti, Michela; Hajeri, Subhas

2017-07-01

Most Citrus tristeza virus (CTV) isolates in California are biologically mild and symptomless in commercial cultivars on CTV tolerant rootstocks. However, to better define California CTV isolates showing divergent serological and genetic profiles, selected isolates were subjected to deep sequencing of small RNAs. Full-length sequences were assembled, annotated and trifoliate orange resistance-breaking (RB) isolates of CTV were identified. Phylogenetic relationships based on their full genomes placed three isolates in the RB clade: CA-RB-115, CA-RB-AT25, and CA-RB-AT35. The latter two isolates were obtained by aphid transmission from Murcott and Dekopon trees, respectively, containing CTV mixtures. The California RB isolates were further distinguished into two subclades. Group I included CA-RB-115 and CA-RB-AT25 with 99% nucleotide sequence identity with RB type strain NZRB-G90; and group II included CA-RB-AT35 with 99 and 96% sequence identity with Taiwan Pumelo/SP/T1 and HA18-9, respectively. The RB phenotype was confirmed by detecting CTV replication in graft-inoculated Poncirus trifoliata and transmission from P. trifoliata to sweet orange. The California RB isolates induced mild symptoms compared with severe isolates in greenhouse indexing tests. Further examination of 570 CTV accessions, acquired from approximately 1960 and maintained in planta at the Central California Tristeza Eradication Agency, revealed 16 RB positive isolates based on partial p65 sequences. Six isolates collected from 1992 to 2011 from Tulare and Kern counties were CA-RB-115-like; and 10 isolates collected from 1968 to 2010 from Riverside, Fresno, and Kern counties were CA-RB-AT35-like. The presence of the RB genotype is relevant because P. trifoliata and its hybrids are the most popular rootstocks in California.

76 FR 72197 - Yuba County Water Agency; Notice of Panel Meeting and Technical Conference Details

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-22

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 2246-058] Yuba County Water... for the Yuba County Water Agency's (YCWA) Yuba River Hydroelectric Project No. 2246. NMFS disputed the... for anadromous fish; (2) hydrology for anadromous fish; (3) water temperatures for anadromous fish...

7 CFR 1429.102 - Administration.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 10 2014-01-01 2014-01-01 false Administration. 1429.102 Section 1429.102 Agriculture... § 1429.102 Administration. (a) The Asparagus Revenue Market Loss Assistance Payment Program will be... Administration (FSA)), or a designee, and will be carried out in the field by FSA State and county committees and...

7 CFR 1429.102 - Administration.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 10 2013-01-01 2013-01-01 false Administration. 1429.102 Section 1429.102 Agriculture... § 1429.102 Administration. (a) The Asparagus Revenue Market Loss Assistance Payment Program will be... Administration (FSA)), or a designee, and will be carried out in the field by FSA State and county committees and...

ORANGES evaluation final report : for the US DOT sponsored evaluation of the ORANGES electronic payment systems field operational test

DOT National Transportation Integrated Search

2004-12-06

This report describes the findings of the US DOT-sponsored evaluation of the Orlando (Florida) ORANGES multi-modal Field Operational Test (FOT); the report includes: a background description of the ORANGES FOT; the Evaluation Strategy and Plan, which...

The draft genome of sweet orange (Citrus sinensis).

PubMed

Xu, Qiang; Chen, Ling-Ling; Ruan, Xiaoan; Chen, Dijun; Zhu, Andan; Chen, Chunli; Bertrand, Denis; Jiao, Wen-Biao; Hao, Bao-Hai; Lyon, Matthew P; Chen, Jiongjiong; Gao, Song; Xing, Feng; Lan, Hong; Chang, Ji-Wei; Ge, Xianhong; Lei, Yang; Hu, Qun; Miao, Yin; Wang, Lun; Xiao, Shixin; Biswas, Manosh Kumar; Zeng, Wenfang; Guo, Fei; Cao, Hongbo; Yang, Xiaoming; Xu, Xi-Wen; Cheng, Yun-Jiang; Xu, Juan; Liu, Ji-Hong; Luo, Oscar Junhong; Tang, Zhonghui; Guo, Wen-Wu; Kuang, Hanhui; Zhang, Hong-Yu; Roose, Mikeal L; Nagarajan, Niranjan; Deng, Xiu-Xin; Ruan, Yijun

2013-01-01

Oranges are an important nutritional source for human health and have immense economic value. Here we present a comprehensive analysis of the draft genome of sweet orange (Citrus sinensis). The assembled sequence covers 87.3% of the estimated orange genome, which is relatively compact, as 20% is composed of repetitive elements. We predicted 29,445 protein-coding genes, half of which are in the heterozygous state. With additional sequencing of two more citrus species and comparative analyses of seven citrus genomes, we present evidence to suggest that sweet orange originated from a backcross hybrid between pummelo and mandarin. Focused analysis on genes involved in vitamin C metabolism showed that GalUR, encoding the rate-limiting enzyme of the galacturonate pathway, is significantly upregulated in orange fruit, and the recent expansion of this gene family may provide a genomic basis. This draft genome represents a valuable resource for understanding and improving many important citrus traits in the future.

78 FR 25484 - License Amendment for Anadarko Petroleum Corporation, Bear Creek Facility, Converse County, Wyoming

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-01

... NUCLEAR REGULATORY COMMISSION [Docket No.: 40-8452; NRC-2012-0095] License Amendment for Anadarko Petroleum Corporation, Bear Creek Facility, Converse County, Wyoming AGENCY: Nuclear Regulatory Commission... License SUA- 1310 issued to Anadarko Petroleum Corporation (APC or the licensee) to authorize alternate...

A Comparison of Full-Time Faculty Members and Administrators with Respect to Their Perceived Impacts of Selected Societal Factors on Mercer County Community College.

ERIC Educational Resources Information Center

Bolge, Robert D.

A study was conducted at Mercer County Community College (MCCC), in New Jersey, to compare the perceptions of full-time faculty and administrators of the impact of selected societal factors on the college and provide MCCC with a theoretical basis for implementing its strategic planning model. A survey inventory of 34 societal factors was…

78 FR 16490 - Placer County Water Agency; Notice of Authorization for Continued Project Operation

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-15

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 2079-000] Placer County Water Agency; Notice of Authorization for Continued Project Operation On February 23, 2011, the Placer County Water Agency, licensee for the Middle Fork American River Hydroelectric Project, filed an Application for a New License pursuant to the Federa...

Fresh squeezed orange juice odor: a review.

PubMed

Perez-Cacho, Pilar Ruiz; Rouseff, Russell L

2008-08-01

Fresh orange juice is a highly desirable but unstable product. This review examines analytical findings, odor activity, and variations due to cultivar, sampling methods, manner of juicing, plus possible enzymatic and microbial artifacts. Initial attempts to characterize orange juice odor were based on volatile quantitation and overemphasized the importance of high concentration volatiles. Although over 300 volatiles have been reported from GC-MS analytical studies, this review presents 36 consensus aroma active components from GC-olfactometry studies consisting of 14 aldehydes, 7 esters, 5 terpenes, 6 alcohols, and 4 ketones. Most are trace (microg/L) components. (+)-Limonene is an essential component in orange juice odor although its exact function is still uncertain. Total amounts of volatiles in mechanically squeezed juices are three to 10 times greater than hand-squeezed juices because of elevated peel oil levels. Elevated peel oil changes the relative proportion of several key odorants. Odor active components from solvent extraction studies differ from those collected using headspace techniques as they include volatiles with low vapor pressure such as vanillin. Some reported odorants such as 2,3-butanedione are microbial contamination artifacts. Orange juice odor models confirm that fresh orange aroma is complex as the most successful models contain 23 odorants.

21 CFR 82.1261 - D&C Orange No. 11.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 11. 82.1261 Section 82.1261 Food... CERTIFIED PROVISIONALLY LISTED COLORS AND SPECIFICATIONS Drugs and Cosmetics § 82.1261 D&C Orange No. 11. The color additive D&C Orange No. 11 shall conform in identity and specifications to the requirements...

21 CFR 82.1260 - D&C Orange No. 10.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 10. 82.1260 Section 82.1260 Food... CERTIFIED PROVISIONALLY LISTED COLORS AND SPECIFICATIONS Drugs and Cosmetics § 82.1260 D&C Orange No. 10. The color additive D&C Orange No. 10 shall conform in identity and specifications to the requirements...

76 FR 71008 - Yuba County Water Agency; Notice of Dispute Resolution Process Schedule; Panel Meeting, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-16

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 2246-058] Yuba County Water..., in the relicensing proceeding for the Yuba County Water Agency's (YCWA) Yuba River Hydroelectric... related activities on: (1) Fish passage for anadromous fish; (2) hydrology for anadromous fish; (3) water...

75 FR 68662 - Environmental Impact Statement: St. Louis County, MO

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-08

... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Environmental Impact Statement: St... Hanley Road southeastward to River Des Peres Boulevard and Lansdowne Avenue in St. Louis County, Missouri...: Mr. John Hicks, Transportation Development Analyst, St. Louis County Department of Highways and...

7 CFR 1221.229 - FSA county office report.

Code of Federal Regulations, 2014 CFR

2014-01-01

... county FSA office report shall be certified as accurate and complete by the CED or designee, acting on... released by the Secretary. A copy of the report shall be posted for 30 calendar days following the date of notification by the Administrator, FSA, in the county FSA office in a conspicuous place accessible to the...

7 CFR 1221.229 - FSA county office report.

Code of Federal Regulations, 2012 CFR

2012-01-01

... county FSA office report shall be certified as accurate and complete by the CED or designee, acting on... released by the Secretary. A copy of the report shall be posted for 30 calendar days following the date of notification by the Administrator, FSA, in the county FSA office in a conspicuous place accessible to the...

7 CFR 1221.229 - FSA county office report.

Code of Federal Regulations, 2011 CFR

2011-01-01

... county FSA office report shall be certified as accurate and complete by the CED or designee, acting on... released by the Secretary. A copy of the report shall be posted for 30 calendar days following the date of notification by the Administrator, FSA, in the county FSA office in a conspicuous place accessible to the...

7 CFR 1221.229 - FSA county office report.

Code of Federal Regulations, 2013 CFR

2013-01-01

... county FSA office report shall be certified as accurate and complete by the CED or designee, acting on... released by the Secretary. A copy of the report shall be posted for 30 calendar days following the date of notification by the Administrator, FSA, in the county FSA office in a conspicuous place accessible to the...

PHOTOMICROGRAPH - SPHERE FRAGMENTS - "ORANGE" SOIL - APOLLO 17 - MSC

NASA Image and Video Library

1973-01-04

S73-15171 (4 Jan. 1973) --- These orange glass spheres and fragments are the finest particles ever brought back from the moon. Ranging in size from 20 to 45 microns (about 1/1000 of an inch) the particles are magnified 160 times in this photomicrograph made in the Lunar Receiving Laboratory at the Manned Spacecraft Center. The orange soil was brought back from the Taurus-Littrow landing site by the Apollo 17 crewmen. Scientist-astronaut Harrison H. "Jack" Schmitt discovered the orange soil at Shorty Crater during the second Apollo 17 extravehicular activity (EVA). This lunar material is being studied and analyzed by scientists in the LRL. The orange particles in this photomicrograph, which are intermixed with black and black-speckled grains, are about the same size as the particles that compose silt on Earth. Chemical analysis of the orange soil material has shown the sample to be similar to some of the samples brought back from the Apollo 11 (Sea of Tranquility) site several hundred miles to the southwest. Like those samples, it is rich in titanium (8%) and iron oxide (22%). But unlike the Apollo 11 samples, the orange soil is unexplainably rich in zinc ? an anomaly that has scientists in a quandary. This Apollo 17 sample is not high in volatile elements, nor do the minerals contain substantial amounts of water. These would have provided strong evidence of volcanic activity. On the other hand, the lack of agglutinates (rocks made up of a variety of minerals cemented together) indicates that the orange glass is probably not the product of meteorite impact -- strengthening the argument that the glass was produced by volcanic activity.

24 CFR 570.510 - Transferring projects from urban counties to metropolitan cities.

Code of Federal Regulations, 2011 CFR

2011-04-01

... counties to metropolitan cities. 570.510 Section 570.510 Housing and Urban Development Regulations Relating... GRANTS Grant Administration § 570.510 Transferring projects from urban counties to metropolitan cities... county to a new metropolitan city, provided: the city was an included unit of general local government in...

24 CFR 570.510 - Transferring projects from urban counties to metropolitan cities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... counties to metropolitan cities. 570.510 Section 570.510 Housing and Urban Development Regulations Relating... GRANTS Grant Administration § 570.510 Transferring projects from urban counties to metropolitan cities... county to a new metropolitan city, provided: the city was an included unit of general local government in...

ORANGES evaluation final report appendices : for the US DOT sponsored evaluation of the ORANGES electronic payment systems field operational test

DOT National Transportation Integrated Search

2004-12-06

These are the appendices for the report describing the findings of the US DOT-sponsored evaluation of the Orlando (Florida) ORANGES multi-modal Field Operational Test (FOT); the report includes: a background description of the ORANGES FOT; the Evalua...

21 CFR 74.1255 - D&C Orange No. 5.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 5. 74.1255 Section 74.1255 Food and... ADDITIVES SUBJECT TO CERTIFICATION Drugs § 74.1255 D&C Orange No. 5. (a) Identity. (1) the color additive D&C Orange No. 5 is a mixture consisting principally the sodium salt of 4′,5′-dibromofluorescein (CAS...

21 CFR 74.1261 - D&C Orange No. 11.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 11. 74.1261 Section 74.1261 Food... COLOR ADDITIVES SUBJECT TO CERTIFICATION Drugs § 74.1261 D&C Orange No. 11. (a) Identity. (1) The color additive D&C Orange No. 11 is a mixture consisting principally of the disodium salts of 4′,5...

21 CFR 74.1254 - D&C Orange No. 4.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 4. 74.1254 Section 74.1254 Food and... ADDITIVES SUBJECT TO CERTIFICATION Drugs § 74.1254 D&C Orange No. 4. (a) Identity. (1) the color additive D&C Orange No. 4 is principally the sodium salt of 4-[(2-hydroxy-1-naphthalenyl)azo]benzenesulfonic...

21 CFR 82.1254 - D&C Orange No. 4.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 4. 82.1254 Section 82.1254 Food and... PROVISIONALLY LISTED COLORS AND SPECIFICATIONS Drugs and Cosmetics § 82.1254 D&C Orange No. 4. The color additive D&C Orange No. 4 shall conform in identity and specifications to the requirements of § 74.1254(a...

[City and County Records.

ERIC Educational Resources Information Center

Combs, Judith O.; And Others

Six papers presented at the Institute were concerned with city and county records. They are: "EWEB and Its Records," which discusses the history, laws and records of the Eugene Water and Electric Board (EWEB);""Police Records: Eugene, Oregon," classifies police records, other than administrative, into three general…

76 FR 56492 - Environmental Impact Statement: St. Louis County, Missouri

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-13

... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Environmental Impact Statement: St.../Shackelford Road in northwestern St. Louis County, Missouri. These roads lie within the floodplain of the... Manager, St. Louis County Department of Highways and Traffic, 121 S. Meramec Avenue, Clayton, Missouri...

Public vs private administration of rural health insurance schemes: a comparative study in Zhejiang of China.

PubMed

Zhou, Xiaoyuan; Mao, Zhengzhong; Rechel, Bernd; Liu, Chaojie; Jiang, Jialin; Zhang, Yinying

2013-07-01

Since 2003, China has experimented in some of the country's counties with the private administration of the New Cooperative Medical Scheme (NCMS), a publicly subsidized health insurance scheme for rural populations. Our study compared the effectiveness and efficiency of private vs public administration in four counties in one of China's most affluent provinces in the initial stage of the NCMS's implementation. The study was undertaken in Ningbo city of Zhejiang province. Out of 10 counties in Ningbo, two counties with private administration for the NCMS (Beilun and Ninghai) were compared with two others counties with public administration (Zhenhai and Fenghua), using the following indicators: (1) proportion of enrollees who were compensated for inpatient care; (2) average reimbursement-expense ratio per episode of inpatient care; (3) overall administration cost; (4) enrollee satisfaction. Data from 2004 to 2006 were collected from the local health authorities, hospitals and the contracted insurance companies, supplemented by a randomized household questionnaire survey covering 176 households and 479 household members. In our sample counties, private administration of the NCMS neither reduced transaction costs, nor improved the benefits of enrollees. Enrollees covered by the publicly administered NCMS were more likely to be satisfied with the insurance scheme than those covered by the privately administered NCMS. Experience in the selected counties suggests that private administration of the NCMS did not deliver the hoped-for results. We conclude that caution needs to be exercised in extending private administration of the NCMS.

7 CFR 7.1 - Administration.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Administration. 7.1 Section 7.1 Agriculture Office of the Secretary of Agriculture SELECTION AND FUNCTIONS OF AGRICULTURAL STABILIZATION AND CONSERVATION STATE, COUNTY AND COMMUNITY COMMITTEES § 7.1 Administration. (a) The regulations of this part are...

7 CFR 7.1 - Administration.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 1 2012-01-01 2012-01-01 false Administration. 7.1 Section 7.1 Agriculture Office of the Secretary of Agriculture SELECTION AND FUNCTIONS OF AGRICULTURAL STABILIZATION AND CONSERVATION STATE, COUNTY AND COMMUNITY COMMITTEES § 7.1 Administration. (a) The regulations of this part are...

7 CFR 7.1 - Administration.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 1 2011-01-01 2011-01-01 false Administration. 7.1 Section 7.1 Agriculture Office of the Secretary of Agriculture SELECTION AND FUNCTIONS OF AGRICULTURAL STABILIZATION AND CONSERVATION STATE, COUNTY AND COMMUNITY COMMITTEES § 7.1 Administration. (a) The regulations of this part are...

Orange peel products can reduce Salmonella populations in ruminants.

PubMed

Callaway, Todd R; Carroll, Jeffery A; Arthington, John D; Edrington, Tom S; Anderson, Robin C; Rossman, Michelle L; Carr, Mandy A; Genovese, Ken J; Ricke, Steve C; Crandall, Phil; Nisbet, David J

2011-10-01

Salmonella can live undetected in the gut of food animals and be transmitted to humans. Animal diets can impact intestinal populations of foodborne pathogens, including Salmonella spp. Orange juice production results in a waste product, orange peel and orange pulp, which has a high nutritive value and is often included in cattle diets as a least-cost ration ingredient. Here we show that the inclusion of orange peel products reduced Salmonella Typhimurium populations in the gut of experimentally inoculated sheep. Sheep (n=24) were fed a cracked corn grain-based high grain diet that was supplemented with a 50%/50% (dry matter [DM], w/w) mixture of dried orange pellet and fresh orange peel to achieve a final concentration (DM, basis) of 0%, 10%, or 20% orange product (OP) for 10 days before inoculation with Salmonella Typhimurium. Sheep were experimentally inoculated with 10(10) colony forming units Salmonella Typhimurium, and fecal samples were collected every 24 h after inoculation. Sheep were humanely euthanized at 96 h after oral Salmonella inoculation. Populations of inoculated Salmonella Typhimurium were numerically reduced by OP treatment throughout the gastrointestinal tract, and this reduction only reached significant levels in the cecum (p<0.05) of sheep fed 10% OP diets. Apparent palatability issues decreased the consumption of OP in sheep fed 20% OP to intake levels below that of 10% OP (approximately 7% dry matter intake [DMI]/d feed refusal), thereby reducing the potential effects of OP feeding at this higher level. Our results demonstrate that orange peel and pellets are environmentally friendly and low-cost products that can be used as a pre-harvest intervention as part of an integrated pathogen reduction scheme.

Geochemical Characterization of Shallow and Deep Aquifer Mixing in the East Newport Mesa Area, Orange County, CA

NASA Astrophysics Data System (ADS)

Neel, B.; Hagedorn, B.; Xu, X.; Walker, J. C.

2016-12-01

of seawater from the Upper Newport Back Bay into the mesa. This conceptual model will potentially serve as the foundation for a numerical flow model, and related contaminant transport model, with implications for managing and protecting drinking water production wells in the Orange County Groundwater Basin.

Acridine Orange/exosomes increase the delivery and the effectiveness of Acridine Orange in human melanoma cells: A new prototype for theranostics of tumors.

PubMed

Iessi, Elisabetta; Logozzi, Mariantonia; Lugini, Luana; Azzarito, Tommaso; Federici, Cristina; Spugnini, Enrico Pierluigi; Mizzoni, Davide; Di Raimo, Rossella; Angelini, Daniela F; Battistini, Luca; Cecchetti, Serena; Fais, Stefano

2017-12-01

Specifically targeted drug delivery systems with low immunogenicity and toxicity are deemed to increase efficacy of cancer chemotherapy. Acridine Orange (AO) is an acidophilic dye with a strong tumoricidal action following excitation with a light source at 466 nm. However, to date the clinical use of AO is limited by the potential side effects elicited by systemic administration. The endogenous nanocarrier exosomes have been recently introduced as a natural delivery system for therapeutic molecules. In this article, we show the outcome of the administration to human melanoma cells of AO charged Exosomes (Exo-AO), in both monolayer and spheroid models. The results showed an extended drug delivery time of Exo-AO to melanoma cells as compared to the free AO, improving the cytotoxicity of AO. This study shows that Exo-AO have a great potential for a real exploitation as a new theranostic approach against tumors based on AO delivered through the exosomes.

7 CFR 29.1044 - Orange Red (FR).

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Orange Red (FR). 29.1044 Section 29.1044 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1044 Orange Red (FR). A yellowish red. [42 FR 21092, Apr. 25, 1977. Redesignated at 47 FR...

Volatile and nonvolatile flavor chemical evaluation of USDA orange-mandarin hybrids for comparison to sweet orange and mandarin fruit

USDA-ARS?s Scientific Manuscript database

Three citrus hybrids, containing 50-75% sweet orange (Citrus sinensis) genome in their pedigrees and similar to sweet orange in fruit size, color and taste, were tested for their potential to be classified as new “sweet orange” cultivars. 'Hamlin', ‘Midsweet’, and three other early to mid-season swe...

Moro orange juice prevents fatty liver in mice.

PubMed

Salamone, Federico; Li Volti, Giovanni; Titta, Lucilla; Puzzo, Lidia; Barbagallo, Ignazio; La Delia, Francesco; Zelber-Sagi, Shira; Malaguarnera, Michele; Pelicci, Pier Giuseppe; Giorgio, Marco; Galvano, Fabio

2012-08-07

To establish if the juice of Moro, an anthocyanin-rich orange, may improve liver damage in mice with diet-induced obesity. Eight-week-old mice were fed a high-fat diet (HFD) and were administrated water or Moro juice for 12 wk. Liver morphology, gene expression of lipid transcription factors, and metabolic enzymes were assessed. Mice fed HFD displayed increased body weight, insulin resistance and dyslipidemia. Moro juice administration limited body weight gain, enhanced insulin sensitivity, and decreased serum triglycerides and total cholesterol. Mice fed HFD showed liver steatosis associated with ballooning. Dietary Moro juice markedly improved liver steatosis by inducing the expression of peroxisome proliferator-activated receptor-α and its target gene acylCoA-oxidase, a key enzyme of lipid oxidation. Consistently, Moro juice consumption suppressed the expression of liver X receptor-α and its target gene fatty acid synthase, and restored liver glycerol-3-phosphate acyltransferase 1 activity. Moro juice counteracts liver steatogenesis in mice with diet-induced obesity and thus may represent a promising dietary option for the prevention of fatty liver.

21 CFR 74.1260 - D&C Orange No. 10.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 10. 74.1260 Section 74.1260 Food... COLOR ADDITIVES SUBJECT TO CERTIFICATION Drugs § 74.1260 D&C Orange No. 10. (a) Identity. (1) The color additive D&C Orange No. 10 is a mixture consisting principally of 4′,5′-diiodofluorescein, 2′,4′,5...

7 CFR 905.306 - Orange, Grapefruit, Tangerine and Tangelo Regulation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Orange, Grapefruit, Tangerine and Tangelo Regulation... AGRICULTURE ORANGES, GRAPEFRUIT, TANGERINES, AND TANGELOS GROWN IN FLORIDA Grade and Size Requirements § 905.306 Orange, Grapefruit, Tangerine and Tangelo Regulation. (a) During the period specified in column (2...

78 FR 78355 - San Diego County Water Authority; Notice of Preliminary Permit Application Accepted For Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-26

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 12747-002] San Diego County Water Authority; Notice of Preliminary Permit Application Accepted For Filing and Soliciting Comments, Motions To Intervene, and Competing Applications On July 1, 2013, the San Diego County Water Authority filed an application for a preliminary...

Operations Under the Airport and Airway Development Act of 1970.

DTIC Science & Technology

1980-01-01

Orange County Air (ANCLUC). John Wayne Airport Ar taeer 74,a25 (Orange county)rri Santa Rosa General Airport Master Plan. Sonoma county Aviation...Rosa 08 $ 152,095 Reconstruct and mark taxiways; Sonoma County drainage; relocate taxiway lighting. South Lake Tahoe 05 199,460 Acquire crash/fire

Influence of Urbanicity and County Characteristics on the ...

EPA Pesticide Factsheets

Background: Air pollution epidemiology studies, often conducted in large metropolitan areas due to proximity to regulatory monitors, are limited in their ability to examine potential associations between air pollution exposures and health effects in rural locations. Methods: In a time-stratified case-crossover framework, we examined associations between asthma emergency department (ED) visits in North Carolina (2006-2008) collected by a surveillance system, and short-term ozone exposures using predicted concentrations from the Community Multiscale Air Quality (CMAQ) model. Associations were estimated by county groupings based on four urbanicity classifications (representative of county size and urban proximity) and county health. Results: Ozone was associated with asthma ED visits in all-year and warm season (April-October) analyses [Odds Ratio (OR) =1.019; 95% CI: 0.998, 1.040; OR=1.020; 95% CI: 0.997, 1.044, respectively, for a 20 ppb increase in lag 0-2 days ozone]. The association was strongest in Less Urbanized counties, with no evidence of a positive association in Rural counties. Associations were similar when adjusted for fine particulate matter in copolluant models. Associations were stronger for children (5-17 years of age) compared with other age groups, and for individuals living in counties with poorer health status compared with counties that had the highest health rankings, although estimated associations for these subgroups were imprecise. Conclu

Orange fiber laser for ophthalmology

NASA Astrophysics Data System (ADS)

Adachi, M.; Kojima, K.; Hayashi, K.

2007-02-01

For the light source of photocoagulators for ophthalmology, orange laser is more suitable than green laser because of low scattering loss by the crystalline lens, and low absorption by xanthophylls in the retina. We developed two orange fiber lasers (580 nm and 590 nm) to investigate the effect depending on the difference in the range of orange. The 580nm laser is composed of a 1160 nm fiber laser and a Periodically Polled Lithium Niobate (PPLN) crystal for second harmonic generation. The 1160 nm fiber laser beam is focused into the MgO-doped PPLN crystal whose length is 30 mm with 3-pass configuration. Continuous-wave 1.3 W output power of 580 nm was obtained with 5.8 W input power of 1160nm for the first time. The conversion efficiency was 22%. The band width of the second harmonic was 0.006 nm (FWHM). The 590 nm laser is almost the same as 580 nm laser source. In this case we used a Raman shift fiber to generate 1180 nm, and the output power of 590 nm was 1.4 W. We developed an evaluation model of photocoagulator system using these two laser sources. A 700 mW coagulation output power was obtained with this orange fiber laser photocoagulator system. This is enough power for the eye surgery. We have the prospect of the maintenance-free, long-life system that is completely air-cooled. We are planning to evaluate this photocoagulator system in order to investigate the difference between the two wavelengths at the field test.

Technical and Regulatory Guidance for In Situ Chemical Oxidation of Contaminated Soil and Groundwater Second Edition

DTIC Science & Technology

2005-01-01

PA Ozone (full scale) Silty sand underlain by fractured schist and shale Petroleum hydrocarbons Former Wood Treatment Site, Sonoma County , CA...Wood Treatment Site, Sonoma County , California Contaminant: Pentachlorophenol and creosote (i.e., PAHs) Oxidant: Ozone Regulatory Agency Contact...topography is essentially flat and paved, and the facility is located on northern Sonoma County , California. The site subsurface consists of very

Extraction of orange peel's essential oil by solvent-free microwave extraction

NASA Astrophysics Data System (ADS)

Qadariyah, Lailatul; Amelia, Prilia Dwi; Admiralia, Cininta; Bhuana, Donny S.; Mahfud, Mahfud

2017-05-01

Sweet orange peel (Citrus sinensis) is part of orange plant that contains essential oils. Generally, taking essential oil from orange peel is still using hydrodistillation and steam-hydrodistillation method which still needs solvent and takes a long time to produce high quality essential oil. Therefore, the objectives of this experiment are to study the process of orange peel's essential oil extraction using Solvent Free Microwave Extraction (SFME) and to study the operating condition that effect an optimum yield and quality of the essential oil. In this experiment, extraction process with SFME method goes for 60 minutes at atmospheric pressure. Variables for SFME are: variation of orange peel condition (fresh and dry), ratio orange peel mass to distiller volume (0,1; 0,2; 0,3; 0,4 g/mL), orange peel size (±0,5; ±2; ±3,5 cm width), and microwave power (100, 264, 400 Watt). Moisture content of fresh peel is 71,4% and for dry peel is 17,37% which is obtained by sun drying. The result of this experiment will be analyzed with GC-MS, SEM, density, and miscibility in ethanol 90%. The optimum result obtained from this experiment based on the number of the yield under condition of fresh orange peel is at peel mass/distiller volume 0,1 g/mL, orange peel size ±3,5 cm width, and microwave power 400 Watt, results 1,6738% yield. The result of GC-MS for fresh orange peel shows that the dominant compound is Limonene 54,140% and for dry orange peel is Limonene 59,705%. The density obtained is around 0,8282-0,8530 g/mL and miscibility in ethanol 90% is 1:5.

β-Cryptoxanthin is more bioavailable in humans from fermented orange juice than from orange juice.

PubMed

Hornero-Méndez, Dámaso; Cerrillo, Isabel; Ortega, Ángeles; Rodríguez-Griñolo, María-Rosario; Escudero-López, Blanca; Martín, Franz; Fernández-Pachón, María-Soledad

2018-10-01

Carotenoids, especially β-cryptoxanthin, exert multiple biological activities in the organism. Various processing techniques can improve carotenoid bioavailability in relation to the food matrix. The study objective was to compare the bioavailability of carotenoids from orange juice (OJ) with that from a beverage obtained by alcoholic fermentation of orange juice (FOB). Seven volunteers were recruited for a randomized, controlled, and crossover study. Post-intake plasma carotenoid concentrations were measured by HPLC in the subjects at 0-8 h after their consumption of OJ or FOB. β-Cryptoxanthin and lutein absorption was significantly higher from FOB than from OJ, but no significant difference in zeaxanthin absorption was found. The mean baseline-corrected area under the concentration curve (AUC 0-8 h ) for β-cryptoxanthin, lutein and zeaxanthin was 24.6-, 1.3- and 4.65-fold larger, respectively, after FOB versus OJ consumption. This fermented orange beverage could be an abundant source of bioavailable carotenoids, and its regular consumption may exert healthy effects. Copyright © 2018 Elsevier Ltd. All rights reserved.

Oranges or "lemons"? Family farming and product quality in the Spanish orange industry, 1870-1960.

PubMed

Garrido, Samuel

2010-01-01

In the early twentieth century California became a big exporter of some agricultural products that, until then, had only been grown on a large scale in the mediterranean basin. As a result, exports of those products diminished or stagnated in Mediterranean countries, with important repercussions on their economies. The Spanish orange industry, however, continued to expand, despite the fact that a substantial percentage of Spanish oranges came from farms owned by (often illiterate) small peasants who, in comparison to the California growers, used a great deal of labor, small amounts of capital, and little science. This paper shows that Spanish farmers were in fact capable of growing high-quality oranges at prices that were more competitive than those in California, although interested they often preferred to satisfy the strong demand for middling fruit from Great Britain because it was a more profitable business. This, combined with a deficient use of brand names, gave the Spanish citrus industry serious reputation problems by the 1930s, from which, however, it recovered quickly.

75 FR 52996 - Draft Regulatory Guide: Issuance, Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

... NUCLEAR REGULATORY COMMISSION [NRC-2010-0287] Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of issuance and availability of Draft Regulatory Guide, DG-8035, ``Administrative Practices in Radiation Surveys and Monitoring.'' FOR FURTHER...

Ground water in Creek County, Oklahoma

USGS Publications Warehouse

Cady, Richard Carlysle

1937-01-01

Creek County has been designated as a problem area by the Land Use Planning Section of the Resettlement Administration. Some of the earliest oil fields to brought into production were situated in and near this county, and new fields have been opened from time to time during the ensuing years. The production of the newer fields, however, has not kept pace with the exhaustion of the older fields, and the county now presents an excellent picture of the problems involved in adjusting a population to lands that are nearly depleted of their mineral wealth. Values of land have been greatly depressed; tax collection is far in arrears; tenancy is widespread; and in addition more people will apparently be forced to depend on the income from agriculture than the land seems capable of supporting. The county as a whole is at best indifferently suitable for general farming. The Land Use planning Section proposes to study the present and seemingly immanent maladjustments of population to the resources of the land, and make recommendations for their correction. The writer was detailed to the Land Use Planning Section of Region VIII for the purposes of making studies of ground water problems in the region. In Creek County two investigations were made. In September, 1936, the writer spent about ten days investigating the availability of ground water for the irrigation of garden crops during drouths. If it proved feasible to do this generally throughout the county, the Land Use Planning Section might be able to encourage this practice. The second investigation made by the writer was in regard to the extent to which ground water supplies have been damaged by oil well brines. He was in county for four days late in January 1937, and again in March, 1937. During part of the second field trip he was accompanied by R.M. Dixon, sanitary engineer of the Water Utilization Unit of the Resettlement Administration. (available as photostat copy only)

3 CFR - Regulatory Compliance

Code of Federal Regulations, 2012 CFR

2012-01-01

... 3 The President 1 2012-01-01 2012-01-01 false Regulatory Compliance Presidential Documents Other Presidential Documents Memorandum of January 18, 2011 Regulatory Compliance Memorandum for the Heads of Executive Departments and Agencies My Administration is committed to enhancing effectiveness and efficiency in Government. Pursuant to the...

75 FR 9476 - Environmental Impact Statement: Salt Lake County, UT

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-02

... Lake County, UT AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of intent. SUMMARY... be prepared for a proposed transportation improvement project in Salt Lake County, Utah. FOR FURTHER... 9A, Salt Lake City, UT 84118, Telephone: (801) 963-0182, E-mail: [email protected] . The Utah...

75 FR 71179 - Environmental Impact Statement: San Diego County, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-22

... Diego County, CA AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of intent. SUMMARY... a proposed highway project in San Diego County, California. DATES: Public Scoping Meeting: January 12, 2011; 5 p.m. to 8 p.m. ADDRESSES: Sherman Heights Community Center, 2258 Island Avenue, San Diego...

75 FR 31835 - Environmental Impact Statement: Calvert and St. Mary's Counties, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-04

...: Calvert and St. Mary's Counties, MD AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of... project in Calvert and St. Mary's Counties, Maryland (Federal Register Vol. 72, No. 203; FR Doc. 07-5190... replacement of MD 4 from MD 2 to MD 235 in Calvert and St. Mary's Counties, a distance of approximately 4.1...

Genetically engineered orange petunias on the market.

PubMed

Bashandy, Hany; Teeri, Teemu H

2017-08-01

Unauthorized genetically engineered orange petunias were found on the market. Genetic engineering of petunia was shown to lead to novel flower color some 20 years ago. Here we show that petunia lines with orange flowers, generated for scientific purposes, apparently found their way to petunia breeding programmes, intentionally or unintentionally. Today they are widely available, but have not been registered for commerce.

[Standardization of the sour orange flower and leaf].

PubMed

Carnat, A; Carnat, A P; Fraisse, D; Lamaison, J L

1999-09-01

Dried flowers (1 batch) and leaves (6 batches) of sour orange Citrus aurantium L. had a similar flavonoid pattern. But the flavonoid levels of flowers were higher than those of leaves. The mean levels of the principal flavonoid compounds were respectively: total flavonoids 12.35 and 1.06%, neohesperidin 5.44 and 0.08%, naringin 1.93 and 0.06%, eriocitrin 0.38 and 0.25%. 18 batches of commercial origine were also examined for a comparative study. Specifications were proposed for a revision of the monographs "Sour orange flower" and "Sour orange leaf" of the French Pharmacopoeia.

7 CFR 7.1 - Administration.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 1 2013-01-01 2013-01-01 false Administration. 7.1 Section 7.1 Agriculture Office of the Secretary of Agriculture SELECTION AND FUNCTIONS OF FARM SERVICE AGENCY STATE AND COUNTY COMMITTEES § 7.1 Administration. (a) The regulations in this part apply to the election and functions of the...

7 CFR 7.29 - Delegation of authority to Deputy Administrator.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Delegation of authority to Deputy Administrator. 7.29... STABILIZATION AND CONSERVATION STATE, COUNTY AND COMMUNITY COMMITTEES § 7.29 Delegation of authority to Deputy... any such office, county executive director, or other county employee, for any and all of the reasons...

Bioactive compounds from orange epicarp to enrich fish burgers.

PubMed

Spinelli, Sara; Lecce, Lucia; Likyova, Desislava; Del Nobile, Matteo Alessandro; Conte, Amalia

2018-05-01

The orange industry produces considerable amounts of by-products, traditionally used for animal feed or fuel production. Most of these by-products could be used as functional ingredients. To assess the potential food application of orange epicarp, different percentages of micro-encapsulated orange extract were added to fresh fish burgers. Then, an in vitro digestion was also carried out, before and after micro-encapsulation, to measure the bio-accessibility of the active compounds. A significant increase of bio-accessibility of bioactive compounds has been observed in the orange epicarp extract after micro-encapsulation by spray-drying. From the sensory point of view, the fish sample enriched with 50 g kg -1 micro-encapsulated extract was the most comparable to the control burger, even if it showed a higher phenolic, flavonoid and carotenoid bio-accessibility. Orange epicarp may be used as a food additive to enhance the health content of food products. The micro-encapsulation is a valid technique to protect the bioactive compounds and increase their bio-accessibility. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

77 FR 22343 - Certain Orange Juice From Brazil

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-13

... INTERNATIONAL TRADE COMMISSION [Investigation No. 731-TA-1089 (Review)] Certain Orange Juice From Brazil Determination On the basis of the record \\1\\ developed in the subject five-year review, the United... Publication 4311 (April 2012), entitled Certain Orange Juice from Brazil: Investigation No. 731-TA-1089...

75 FR 22892 - Environmental Impact Statement: Salt Lake County, UT

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-30

... Lake County, UT AGENCY: Federal Highway Administration (FHWA), USDOT. ACTION: Notice of Intent. SUMMARY... be prepared for a proposed transportation improvement project in Salt Lake County, Utah. FOR FURTHER... 4700 South, Suite 9A, Salt Lake City, UT 84118, telephone (801) 963-0182, e-mail [email protected

Surveillance study of health effects associated with cleanup of a hazardous waste site, Ralph Gray Trucking Company (a/k/a Westminster Tract Number 2633), Westminster, Orange County, California, Region 9: CERCLIS number CAD981995947

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoshiko, S.; Underwood, M.C.; Smith, D.

1999-04-01

Excavation of a Superfund site, the Ralph Gray Truncking Company located in Westminster Orange County, California was anticipated to release sulfur dioxide and other chemicals. The California Department of Health Services, under cooperative agreement with the Agency for Toxic Substances and Disease Registry, conducted a surveillance study to assess whether illnesses were associated with cleanup activities. A panel primarily composed of more sensitive persons (n = 36) was selected to report daily respiratory symptoms and odors. Exposures included sulfur dioxide (SO{sub 2}) measurements and daily tonnage of waste removed. Analysis used Conditional Likelihood Regression and Generalized Estimating Equations (GEE) methods.more » Levels of SO{sub 2} were generally higher than usual ambient air, at times exceeding levels which can cause health effects among asthmatics in laboratory settings. Wheeze and cough were significantly associated with tonnage of waste removed, especially on days when the highest amounts of waste were removed. Upper respiratory symptoms were found to be associated with SO{sub 2}, and weak relationships were found with nausea and burning nose and SO{sub 2}.« less

Red-fleshed sweet orange juice improves the risk factors for metabolic syndrome.

PubMed

Silveira, Jacqueline Q; Dourado, Grace K Z S; Cesar, Thais B

2015-01-01

Orange juice consumption can promote lower levels of oxidative stress and inflammation due to the antioxidant activity of citrus flavonoids and carotenoids. In addition, red-fleshed sweet orange juice (red orange juice) also contains lycopene. This study investigated the effects of red orange juice consumption on risk factors for metabolic syndrome. Volunteers consumed red orange juice daily for 8 weeks, with clinical and biochemical assessments performed at baseline and on the final day. There was no change in the abdominal obesity, but low-density lipoprotein cholesterol, C-reactive protein decreased, while there was an increase of the antioxidant activity in serum after red orange juice consumption. Insulin resistance and systolic blood pressure were reduced in normal-weight volunteers, while diastolic blood pressure decreased in overweight volunteers after intervention. Red orange juice showed anti-inflammatory, antioxidant, and lipid-lowering properties that may prevent the development of metabolic syndrome.

Effects of orange juice on the pharmacokinetics of atenolol.

PubMed

Lilja, J J; Raaska, K; Neuvonen, P J

2005-07-01

Fruit juices can significantly change the pharmacokinetics of several drugs. Our objective was to investigate the effect of orange juice on the pharmacokinetics of the beta-blocking agent atenolol. In a randomized cross-over study with two phases and a washout of 2 weeks, ten healthy volunteers took either 200 ml orange juice or water thrice daily for 3 days and twice on the fourth day. On the morning of day 3, each subject ingested 50 mg atenolol with an additional amount of either 200 ml orange juice or water. The plasma concentrations of atenolol and the cumulative excretion of atenolol into urine were measured up to 33 h after its dosing. Systolic and diastolic blood pressures and heart rate were recorded in a sitting position before the intake of atenolol and 2, 4, 6, and 10 h after. Orange juice decreased the mean peak plasma concentration (C(max)) of atenolol by 49% (range 16-59%, P<0.01), and the mean area under the plasma atenolol concentration-time curve (AUC(0-33 h)) by 40% (range 25-55%, P<0.01). The time of the peak concentration (t(max)) and the elimination half-life (t(1/2)) of atenolol remained unchanged by orange juice. The amount of atenolol excreted into urine was decreased by 38% (range 17-60%, P<0.01), but the renal clearance remained unaltered. The average heart rate was slightly higher during the orange juice+atenolol phase than during the water+atenolol phase. Orange juice moderately interferes with the gastrointestinal absorption of atenolol. This food-drug interaction can be of clinical significance.

21 CFR 146.146 - Frozen concentrated orange juice.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Fruit Juices and Beverages § 146.146 Frozen concentrated orange juice. (a) Frozen concentrated orange... sweetening ingredients specified in paragraph (b) of this section may be added to adjust the final... any added optional sweetening ingredients. The dilution ratio shall be not less than 3 plus 1. For the...

21 CFR 146.146 - Frozen concentrated orange juice.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Fruit Juices and Beverages § 146.146 Frozen concentrated orange juice. (a) Frozen concentrated orange... sweetening ingredients specified in paragraph (b) of this section may be added to adjust the final... any added optional sweetening ingredients. The dilution ratio shall be not less than 3 plus 1. For the...

21 CFR 146.146 - Frozen concentrated orange juice.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Fruit Juices and Beverages § 146.146 Frozen concentrated orange juice. (a) Frozen concentrated orange... sweetening ingredients specified in paragraph (b) of this section may be added to adjust the final... any added optional sweetening ingredients. The dilution ratio shall be not less than 3 plus 1. For the...

21 CFR 146.146 - Frozen concentrated orange juice.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Fruit Juices and Beverages § 146.146 Frozen concentrated orange juice. (a) Frozen concentrated orange... sweetening ingredients specified in paragraph (b) of this section may be added to adjust the final... any added optional sweetening ingredients. The dilution ratio shall be not less than 3 plus 1. For the...

21 CFR 146.146 - Frozen concentrated orange juice.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Fruit Juices and Beverages § 146.146 Frozen concentrated orange juice. (a) Frozen concentrated orange... sweetening ingredients specified in paragraph (b) of this section may be added to adjust the final... any added optional sweetening ingredients. The dilution ratio shall be not less than 3 plus 1. For the...

Commodity Flow Study - Clark County, Nevada, USA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Conway, S.Ph.D.; Navis, I.

2008-07-01

The United States Department of Energy has designated Clark County, Nevada as an 'Affected Unit of Local Government' due to the potential for impacts by activities associated with the Yucca Mountain High Level Nuclear Waste Repository project. Urban Transit, LLC has led a project team of transportation including experts from the University of Nevada Las Vegas Transportation Research Center to conduct a hazardous materials community flow study along Clark County's rail and truck corridors. In addition, a critical infrastructure analysis has also been carried out in order to assess the potential impacts of transportation within Clark County of high levelmore » nuclear waste and spent nuclear fuel to a proposed repository 90 miles away in an adjacent county on the critical infrastructure in Clark County. These studies were designed to obtain information relating to the transportation, identification and routing of hazardous materials through Clark County. Coordinating with the United States Department of Energy, the U.S. Department of Agriculture, the U. S. Federal Highway Administration, the Nevada Department of Transportation, and various other stakeholders, these studies and future research will examine the risk factors along the entire transportation corridor within Clark County and provide a context for understanding the additional vulnerability associated with shipping spent fuel through Clark County. (authors)« less

75 FR 65937 - Fresh Prunes Grown in Designated Counties in Washington and in Umatilla County, OR; Suspension of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-27

...The Department of Agriculture (USDA) is adopting, as a final rule, without change, an interim rule that suspended the reporting and assessment requirements prescribed under the Washington-Oregon fresh prune marketing order. The marketing order regulates the handling of fresh prunes grown in designated counties in Washington and in Umatilla County, Oregon, and is administered locally by the Washington-Oregon Fresh Prune Marketing Committee (Committee). On June 1, 2010, the Committee unanimously voted to terminate Marketing Order No. 924. Since the only regulatory actions then in effect were the reporting and assessment requirements, the Committee included a recommendation to immediately suspend those activities while USDA processes the termination request. The reporting and assessment requirements will remain suspended until reinstated or permanently terminated.

77 FR 66910 - Environmental Impact Statement, San Diego County, California

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-07

... Diego County, California AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of... Corridor Project in the city of Coronado in San Diego County, California (Federal Register Vol. 72, No 10... 800, San Diego, CA 92101, Regular Office Hours: 6:30 a.m. to 4:00 p.m., Telephone: (619) 699-7336...

A Study of the Job Satisfaction of Special Education Local Plan Area (SELPA) Directors and Local School District Special Education Directors in Four Counties of Southern California

ERIC Educational Resources Information Center

Alexander, Gregory Haynes, III

2009-01-01

Purpose. The purpose of this study was to compare the perceived level of job satisfaction of SELPA directors with that of local school district special education directors in the counties of Riverside, San Bernardino, San Diego, and Orange of Southern California and to identify factors that contribute to their job satisfaction. Additionally, this…

Sedative Effects of Intranasal Midazolam Administration in Wild Caught Blue-fronted Amazon (Amazona aestiva) and Orange-winged Amazon (Amazona amazonica) Parrots.

PubMed

Schaffer, Débora P H; de Araújo, Nayone L L C; Raposo, Ana Cláudia S; Filho, Emanoel F Martins; Vieira, João Victor R; Oriá, Arianne P

2017-09-01

Safe and effective sedation protocols are important for chemical restraint of birds in clinical and diagnostic procedures, such as clinical evaluations, radiographic positioning, and blood collection. These protocols may reduce stress and ease the management of wild-caught birds, which are susceptible to injury or death when exposed to stressful situations. We compare the sedative effect of intranasal midazolam in wild-caught blue-fronted (Amazona aestiva) and orange-winged (Amazona amazonica) Amazon parrots. Ten adult parrots of each species (n = 20), of unknown sex, weighing 0.337 ± 0.04 (blue-fronted) and 0.390 ± 0.03 kg (orange-winged), kg were used. Midazolam (2 mg/kg) was administered intranasally and the total volume of the drug was divided equally between the 2 nostrils. Onset time and total sedation time were assessed. Satisfactory sedation for clinical evaluation was induced in all birds. Onset time and total sedation times were similar in both species: 5.36 ± 1.16 and 25.40 ± 5.72 minutes, respectively, for blue-fronted Amazons and 5.09 ± 0.89 and 27.10 ± 3.73 minutes, respectively, for orange-winged Amazons. A total of 15 animals showed absence of vocalization, with moderate muscle relaxation and wing movement upon handling, and 2 animals presented with lateral recumbence, with intense muscle relaxation and no wing movement, requiring no restraint. Three blue-fronted Amazons had no effective sedation. Intranasally administered midazolam at a dose of 2 mg/kg effectively promoted sedative effects with a short latency time and fast recovery in wild-caught parrots.

77 FR 21785 - Medical Countermeasures Initiative Regulatory Science Symposium

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-11

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0001] Medical Countermeasures Initiative Regulatory Science Symposium AGENCY: Food and Drug Administration, HHS...: Medical Countermeasures Initiative Regulatory Science Symposium. The symposium is intended to provide a...

Cooperation between the U.S. and Vietnamese Governments to Address the Agent Orange Issue in Vietnam

DTIC Science & Technology

2017-06-09

administrative separation at the 17th parallel (lat. 17° N ). The North would be governed by the Viet Minh, and the South by Bao Dai; the conference...28 Vitali Lipik, “Dioxin becomes most dangerous man-made poison,” Pravda Report, June 2005, accessed November 14, 2016, http...26, 2016. http://thediplomat.com/2014/07/agent-orange-legacy- scourges-vietnam/. Lipik, Vitali . “Dioxin becomes most dangerous man-made poison

Development of orange rust of sugarcane in Louisiana

USDA-ARS?s Scientific Manuscript database

Orange rust of sugarcane was observed for the first time in the Americas in 2007 in Florida. Urediniospores of Puccinia kuehnii, the causal agent of orange rust, were collected in aerial traps located in Louisiana in 2010; however, the first observation of disease symptoms in the state was not made ...

1. ADMINISTRATION BUILDING ELEVATION TAKEN OFF THE COMPOUND, ACROSS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. ADMINISTRATION BUILDING ELEVATION - TAKEN OFF THE COMPOUND, ACROSS THE STREET, THROUGH THE PERIMETER FENCE - Middlesex Sampling Plant, Administration Building, 239 Mountain Avenue, Middlesex, Middlesex County, NJ

Differentiation between Flavors of Sweet Orange (Citrus sinensis) and Mandarin (Citrus reticulata).

PubMed

Feng, Shi; Suh, Joon Hyuk; Gmitter, Frederick G; Wang, Yu

2018-01-10

Pioneering investigations referring to citrus flavor have been intensively conducted. However, the characteristic flavor difference between sweet orange and mandarin has not been defined. In this study, sensory analysis illustrated the crucial role of aroma in the differentiation between orange flavor and mandarin flavor. To study aroma, Valencia orange and LB8-9 mandarin were used. Their most aroma-active compounds were preliminarily identified by aroma extract dilution analysis (AEDA). Quantitation of key volatiles followed by calculation of odor activity values (OAVs) further detected potent components (OAV ≥ 1) impacting the overall aromatic profile of orange/mandarin. Follow-up aroma profile analysis revealed that ethyl butanoate, ethyl 2-methylbutanoate, octanal, decanal, and acetaldehyde were essential for orange-like aroma, whereas linalool, octanal, α-pinene, limonene, and (E,E)-2,4-decadienal were considered key components for mandarin-like aroma. Furthermore, an unreleased mandarin hybrid producing fruit with orange-like flavor was used to validate the identification of characteristic volatiles in orange-like aroma.

Blood orange juice inhibits fat accumulation in mice.

PubMed

Titta, L; Trinei, M; Stendardo, M; Berniakovich, I; Petroni, K; Tonelli, C; Riso, P; Porrini, M; Minucci, S; Pelicci, P G; Rapisarda, P; Reforgiato Recupero, G; Giorgio, M

2010-03-01

To analyze the effect of the juice obtained from two varieties of sweet orange (Citrus sinensis L. Osbeck), Moro (a blood orange) and Navelina (a blond orange), on fat accumulation in mice fed a standard or a high-fat diet (HFD). Obesity was induced in male C57/Bl6 mice by feeding a HFD. Moro and Navelina juices were provided instead of water. The effect of an anthocyanin-enriched extract from Moro oranges or purified cyanidin-3-glucoside (C3G) was also analyzed. Body weight and food intake were measured regularly over a 12-week period. The adipose pads were weighted and analyzed histologically; total RNA was also isolated for microarray analysis. Dietary supplementation of Moro juice, but not Navelina juice significantly reduced body weight gain and fat accumulation regardless of the increased energy intake because of sugar content. Furthermore, mice drinking Moro juice were resistant to HFD-induced obesity with no alterations in food intake. Only the anthocyanin extract, but not the purified C3G, slightly affected fat accumulation. High-throughput gene expression analysis of fat tissues confirmed that Moro juice could entirely rescue the high fat-induced transcriptional reprogramming. Moro juice anti-obesity effect on fat accumulation cannot be explained only by its anthocyanin content. Our findings suggest that multiple components present in the Moro orange juice might act synergistically to inhibit fat accumulation.

Assessing a traceability technique in fresh oranges (Citrus sinensis L. Osbeck) with an HS-SPME-GC-MS method. Towards a volatile characterisation of organic oranges.

PubMed

Cuevas, Francisco Julián; Moreno-Rojas, José Manuel; Ruiz-Moreno, María José

2017-04-15

A targeted approach using HS-SPME-GC-MS was performed to compare flavour compounds of 'Navelina' and 'Salustiana' orange cultivars from organic and conventional management systems. Both varieties of conventional oranges showed higher content of ester compounds. On the other hand, higher content of some compounds related with the geranyl-diphosphate pathway (neryl and geranyl acetates) and some terpenoids were found in the organic samples. Furthermore, the partial least square discriminant analysis (PLS-DA) achieved an effective classification for oranges based on the farming system using their volatile profiles (90 and 100% correct classification). To our knowledge, it is the first time that a comparative study dealing with farming systems and orange aroma profile has been performed. These new insights, taking into account local databases, cultivars and advanced analytical tools, highlight the potential of volatile composition for organic orange discrimination. Copyright © 2016 Elsevier Ltd. All rights reserved.

Apollo 17 "Orange soil" and meteorite impact on liquid lava

USGS Publications Warehouse

Roedder, E.; Weiblen, P.W.

1973-01-01

THE 'orange soil' from Shorty Crater differs greatly from ordinary lunar soils in that it consists of ???99% 10-300 ??m smooth shiny spherules and broken fragments of spherules of transparent orange glass, about 20% of which contain partly crystallized to opaque material. The remaining 1 % is chiefly crystalline basalt fragments. Although the colour of the individual orange spherule varies with thickness from yellow-orange to red-brown, all orange glass in our sample (74220, 70; 0.25 g) has a uniform index of refraction (??? 1.712). By contrast, other lunar soils contain spherules ranging from 1.50 to 1.75. The orange glass is also completely free of bubbles, to the limit of resolution of the light microscope, whereas bubbles are present in many other spherule samples. The spherules generally appear spherical in a normal microscope mount, but when viewed from two directions many are found to be oblate spheroids with axial ratios varying from near 1.00 to as low as 0.42 (Fig. 1a). Some have fissioned during free flight1 and all stages of the fission process are found, as described for the Apollo 11 samples. Only a few spherules seem to have been distorted by landing while still soft. One notable exception is the occurrence of small spherules of orange glass conforming and adhering to the surface of larger black spherules (Fig. 1b). ?? 1973 Nature Publishing Group.

Identification of sensory attributes that drive consumer liking of commercial orange juice products in Korea.

PubMed

Kim, Mina K; Lee, Young-Jin; Kwak, Han Sub; Kang, Myung-woo

2013-09-01

Orange juice is a well-accepted fruit juice, and its consumption increases steadily. Many studies have been conducted to understand the sensory characteristics of orange juice throughout its varying processing steps. Sensory language and consumer likings of food can be influenced by culture. The objective of this study is to evaluate the sensory characteristics of commercially available orange juices in Korea and identify drivers of liking for orange juices in Korea. A quantitative descriptive analysis was conducted using a trained panel (n = 10) to evaluate 7 orange juice samples in triplicates, followed by consumer acceptance tests (n = 103). Univariate and multivariate statistical analyses were conducted for data analysis. The sensory characteristics of commercially available orange juice were documented and grouped: group 1 samples were characterized by high in natural citrus flavors such as orange peel, orange flesh, citrus fruit, and grape fruit, whereas group 2 samples were characterized by processed orange-like flavors such as over-ripe, cooked-orange, and yogurt. Regardless of orange flavor types, a high intensity of orange flavor in orange juice was identified as a driver of liking for orange juices in Korea. Three distinct clusters were segmented by varying sensory attributes that were evaluated by likes and dislikes. Overall, many similarities were noticed between Korean market segment and global orange juice market. By knowing the drivers of liking and understanding the distinct consumer clusters present in the Korean orange juice market, the orange juice industry could improve the strategic marketing of its products in Korea. © 2013 Institute of Food Technologists®

A Mitigation Process for Impacts of the All American Pipeline on Oak Woodlands in Santa Barbara County

Treesearch

Germaine Reyes-French; Timothy J. Cohen

1991-01-01

This paper outlines a mitigation program for pipeline construction impacts to oak tree habitat by describing the requirements for the Offsite Oak Mitigation Program for the All American Pipeline (AAPL) in Santa Barbara County, California. After describing the initial environmental analysis, the County regulatory structure is described under which the plan was required...

75 FR 81264 - Public Utility District No. 1 of Douglas County; Notice of Intent To Prepare an Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 2149-152] Public Utility District No. 1 of Douglas County; Notice of Intent To Prepare an Environmental Impact Statement December 16, 2010. On May 27, 2010, Public Utility District No. 1 of Douglas County filed an application for the...

75 FR 17793 - Public Federal Regulatory Enforcement Fairness Hearing; Region III Regulatory Fairness Board

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-07

... Regulatory Fairness Board Pursuant to the Federal Advisory Committee Act, 5 U.S.C. Appendix 2, notice is hereby given that the U.S. Small Business Administration (SBA) Region III Regulatory Fairness Board and... and Development Authority, Virginia Housing Center, 4224 Cox Road, Glen Allen, VA 23060-3318. The...

Vertical surface displacements along a part of the Newport-Inglewood zone of folds and faults, Los Angeles and Orange counties, California

USGS Publications Warehouse

Castle, Robert O.; Buchanan-Banks, Jane M.

1989-01-01

During the past half century, the onshore section of the Newport- Inglewood zone of folds and faults between the Dominguez oil field and Corona del Mar (fig. 1) has been repeatedly leveled to geodetic standards. These essentially fortuitous surveys are unrelated to either the tectonic framework or the urbanization of the Los Angeles basin, but were established instead because the Newport-Inglewood zone southward from the Long Beach area is roughly coincident with the coastline--and, hence, is roughly coincident with a naturally defined leveling route. Although these have been several relevelings athwart this zone north of the long Beach area, notably in the Baldwin Hills area (Castle and Yerkes, 1976), about 25 km to the northwest, the survey density, in both space and time, diminishes markedly northward. Thus, the results of the indicated relevelings along the Los Angeles-Orange County coast have permitted the relatively detailed appraisal of historic vertical surface movements described in this report. The Newport-Inglewood zone of folds and faults forms the surface expression of a major crustal boundary separating the Peninsular Ranges province on the east from the Continental Borderland province on the west (Castle and others, 1984, p. 8-9, pl. 1). Transcurrent fault movement along this boundary has produced not only continuing seismic activity, for which this zone is justly famous, but also folds and other structural features within the sedimentary veneer that have entrapped the petroleum deposits for which the Newport-Inglewood zone is even more famous. Although the northeast boundary of the exceptionally prolific Wilmington oil field is roughly coincident with the southeast edge of the Newport-Inglewood zone, we have deliberately excluded this area from consideration--in other than a peripheral way--simply because compaction-induced subsidence centering on the Wilmington field is viewed as a singularly spectacular example of this phenomenon and, hence, has

Characterization of orange oil microcapsules for application in textiles

NASA Astrophysics Data System (ADS)

Rossi, W.; Bonet-Aracil, M.; Bou-Belda, E.; Gisbert-Payá, J.; Wilson, K.; Roldo, L.

2017-10-01

The use of orange oil presents as an ecological alternative to chemicals, attracting the attention of the scientific community to the development of eco-friendly antimicrobials. The microencapsulation technology has been used for the application of orange oil to textiles, being an economically viable, fast and efficient method by combining core and shell materials, desirable perceptual and functional characteristics, responsible for properties related to the nature of the product and provides that the wall materials release the functional substances in a controlled manner, in addition to effectively protecting and isolating the core material from the external environment to prevent its volatilization and deterioration, increasing the stability of the oil, such as non-toxicity. Thus, to better exploit the properties of the orange essential oil applied to textile products this study presents a characterization of microcapsules of Melamine formaldehyde obtained by the interfacial polymerization method with variations of proportions of orange oil (volatile) with fixed oil Medium-Chain Triglycerides (MCT) (non-volatile) to assist in the stability of the orange essential oil. Scanning electron microscope (SEM) was used as visualizing tool to characterize microparticles and surface morphology and thermal characteristics of microcapsules were premeditated by mean Differential scanning calorimetry (DSC).

Variation in rotavirus vaccine coverage by sub-counties in Kenya.

PubMed

Wandera, Ernest Apondi; Mohammad, Shah; Ouko, John Odhiambo; Yatitch, James; Taniguchi, Koki; Ichinose, Yoshio

2017-01-01

Rotavirus gastroenteritis is an important cause of childhood morbidity and mortality in Kenya. In July 2014, Kenya introduced the rotavirus vaccine into her national immunization program. Although immunization coverage is crucial in assessing the real-world impact of this vaccine, variability in the vaccine coverage across the country is likely to occur. In view of this, we estimated the extent of coverage for the rotavirus vaccine at two socio-economically different sub-counties using the administrative data. The findings indicate disparities in vaccine coverage and access between the sub-counties and, thus, underscore the need to strengthen immunization systems to facilitate timely, accessible, and equitable vaccine delivery across the country. Both sub-counties recorded high vaccine dropout, suggestive of poor utilization of the vaccine. In this regard, increased social mobilization is needed to encourage vaccine compliance and to enhance tracking of vaccine defaulters. While efforts to improve the accuracy of the administrative coverage estimates are crucial, vaccination coverage surveys will be needed to verify the administrative coverage data and help identify specific factors relating to rotavirus vaccine coverage in the country.

Transport and bioaccumulation of polychlorinated dibenzo-p-dioxins and dibenzofurans at the Bien Hoa Agent Orange hotspot in Vietnam.

PubMed

Van Thuong, Nguyen; Hung, Nguyen Xuan; Mo, Nguyen Thi; Thang, Nguyen Manh; Huy, Pham Quang; Van Binh, Hoang; Nam, Vu Duc; Van Thuy, Nguyen; Son, Le Ke; Minh, Nguyen Hung

2015-10-01

The Bien Hoa airbase (south of Vietnam) is known as one of the Agent Orange hotspots which have been seriously contaminated by Agent Orange/dioxin during the Vietnam War. Hundreds of samples including soil, sediment and fish were collected at the Bien Hoa Agent Orange hotspot for assessment of the environmental contamination caused by dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs). The toxicity equivalency quotient (TEQ) concentration of PCDD/Fs in soil and sediment varied from 7.6 to 962,000 and 17 to 4860 pg/g dry wt, respectively, implying very high contamination of PCDD/Fs in several areas. PCDD/F levels in fish ranged between 1.8 and 288 pg/g TEQ wet wt and was generally higher than advisory guidelines for food consumption. 2,3,7,8-Tetrachlorinated dibenzo-p-dioxins (2,3,7,8-TCDD) contributed 66-99 % of TEQ for most of the samples, suggesting 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) from Agent Orange as the major source of the contamination. The vertical transport of PCDD/Fs was observed in soil column with high TEQ levels above 1000 pg/g dry wt (Vietnamese limit for necessary remediation activities- TCVN 8183:2009 (2009)) even at a depth of 1.8 m. The vertical transport of PCDD/Fs has probably mainly taken place during the "Ranch Hand" defoliant spray activities due to the leaks and spills of phenoxy herbicides and solvents. The congener patterns suggest that transports of PCDD/Fs by weathering processes have led to their redistribution in the low-land areas. Also, an estimate for the total volume of contaminated soil requiring remediation to meet Vietnamese regulatory limits is provided.

Inhibitors of 15-lipoxygenase from orange peel.

PubMed

Malterud, K E; Rydland, K M

2000-11-01

A series of polymethoxylated flavonoids has been isolated from orange peel, and their inhibitory activity toward soybean 15-lipoxygenase was determined. The strongest inhibition was shown by 3,5,6,7,3',4'-hexamethoxyflavone (IC(50) = 49 +/- 5 microM). Sinensetin, nobiletin, tangeretin, tetramethylscutellarein, and 3,5, 6,7,8,3',4'-heptamethoxyflavone were somewhat less active, with IC(50) values of 70-86 microM, comparable to the positive control quercetin (IC(50) = 68 +/- 5 microM). Demethylation apparently results in less active compounds, with 5-O-demethylsinensetin having an IC(50) value of 144 +/- 10 microM. Some other orange peel constituents were isolated and tested as well, hesperidin (IC(50) = 180 +/- 10 microM) and ferulic acid (111 +/- 2 microM), showing moderate activity. The polymethoxylated flavonoids were virtually inactive as scavengers of the diphenylpicrylhydrazyl radical. Hesperidin was only slightly active (24.2 +/- 0.7% scavenged at a concentration of 2 mM), and ferulic acid showed good activity (IC(50) = 86.4 +/- 0.7 microM). From this, it appears that orange peel constituents may counteract enzymatic lipid peroxidation processes catalyzed by 15-lipoxygenase in vitro. The radical scavenging activity of orange peel extracts is only modest.

ORANGE: a Monte Carlo dose engine for radiotherapy.

PubMed

van der Zee, W; Hogenbirk, A; van der Marck, S C

2005-02-21

This study presents data for the verification of ORANGE, a fast MCNP-based dose engine for radiotherapy treatment planning. In order to verify the new algorithm, it has been benchmarked against DOSXYZ and against measurements. For the benchmarking, first calculations have been done using the ICCR-XIII benchmark. Next, calculations have been done with DOSXYZ and ORANGE in five different phantoms (one homogeneous, two with bone equivalent inserts and two with lung equivalent inserts). The calculations have been done with two mono-energetic photon beams (2 MeV and 6 MeV) and two mono-energetic electron beams (10 MeV and 20 MeV). Comparison of the calculated data (from DOSXYZ and ORANGE) against measurements was possible for a realistic 10 MV photon beam and a realistic 15 MeV electron beam in a homogeneous phantom only. For the comparison of the calculated dose distributions and dose distributions against measurements, the concept of the confidence limit (CL) has been used. This concept reduces the difference between two data sets to a single number, which gives the deviation for 90% of the dose distributions. Using this concept, it was found that ORANGE was always within the statistical bandwidth with DOSXYZ and the measurements. The ICCR-XIII benchmark showed that ORANGE is seven times faster than DOSXYZ, a result comparable with other accelerated Monte Carlo dose systems when no variance reduction is used. As shown for XVMC, using variance reduction techniques has the potential for further acceleration. Using modern computer hardware, this brings the total calculation time for a dose distribution with 1.5% (statistical) accuracy within the clinical range (less then 10 min). This means that ORANGE can be a candidate for a dose engine in radiotherapy treatment planning.

DRAFT LANDSAT DATA MOSAIC: MONTGOMERY COUNTY, TEXAS; HARRIS COUNTY, TEXAS; FORT BEND COUNTY, TEXAS; BRAZORIA COUNTY, TEXAS; GALVESTON COUNTY, TEXAS

EPA Science Inventory

This is a draft Landsat Data Mosaic, which contains remote sensing information for Montgomery County, Texas Harris County, Texas Fort Bend County, Texas Brazoria County, Texas Galveston County, and Texas Imagery dates on the following dates: October 6, 1999 and September 29, 200...

7 CFR 2.79 - Administrator, Agricultural Marketing Service.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 1 2014-01-01 2014-01-01 false Administrator, Agricultural Marketing Service. 2.79... for Marketing and Regulatory Programs § 2.79 Administrator, Agricultural Marketing Service. (a... following delegations of authority are made by the Under Secretary for Marketing and Regulatory Programs to...

7 CFR 2.79 - Administrator, Agricultural Marketing Service.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 1 2012-01-01 2012-01-01 false Administrator, Agricultural Marketing Service. 2.79... for Marketing and Regulatory Programs § 2.79 Administrator, Agricultural Marketing Service. (a... following delegations of authority are made by the Under Secretary for Marketing and Regulatory Programs to...

7 CFR 2.79 - Administrator, Agricultural Marketing Service.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Administrator, Agricultural Marketing Service. 2.79... for Marketing and Regulatory Programs § 2.79 Administrator, Agricultural Marketing Service. (a... following delegations of authority are made by the Under Secretary for Marketing and Regulatory Programs to...

7 CFR 2.79 - Administrator, Agricultural Marketing Service.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 1 2011-01-01 2011-01-01 false Administrator, Agricultural Marketing Service. 2.79... for Marketing and Regulatory Programs § 2.79 Administrator, Agricultural Marketing Service. (a... following delegations of authority are made by the Under Secretary for Marketing and Regulatory Programs to...

7 CFR 1580.501 - Administration.

Code of Federal Regulations, 2012 CFR

2012-01-01

... be administered by FAS. FAS will publish in the Federal Register the filing dates for commodity... consultation with the Administrator, FAS, authorize the State and County committees to waive or modify non...

7 CFR 1580.501 - Administration.

Code of Federal Regulations, 2014 CFR

2014-01-01

... be administered by FAS. FAS will publish in the Federal Register the filing dates for commodity... consultation with the Administrator, FAS, authorize the State and County committees to waive or modify non...

7 CFR 1580.501 - Administration.

Code of Federal Regulations, 2013 CFR

2013-01-01

... be administered by FAS. FAS will publish in the Federal Register the filing dates for commodity... consultation with the Administrator, FAS, authorize the State and County committees to waive or modify non...

Trends in active pharmaceutical ingredient salt selection based on analysis of the Orange Book database.

PubMed

Paulekuhn, G Steffen; Dressman, Jennifer B; Saal, Christoph

2007-12-27

The Orange Book database published by the U.S. Drug and Food Administration (FDA) was analyzed for the frequency of occurrence of different counterions used for the formation of pharmaceutical salts. The data obtained from the present analysis of the Orange Book are compared to reviews of the Cambridge Structural Database (CSD) and of the Martindale "The Extra Pharmacopoeia". As well as showing overall distributions of counterion usage, results are broken down into 5-year increments to identify trends in counterion selection. Chloride ions continue to be the most frequently utilized anionic counterions for the formation of salts as active pharmaceutical ingredients (APIs), while sodium ions are most widely utilized for the formation of salts starting from acidic molecules. A strong trend toward a wider variety of counterions over the past decade is observed. This trend can be explained by a stronger need to improve physical chemical properties of research and development compounds.

76 FR 31382 - Notice of Issuance of Regulatory Guide

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-31

... NUCLEAR REGULATORY COMMISSION [NRC-2010-0287] Notice of Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide 8.2, Revision 1, ``Administrative Practices in Radiation Surveys and Monitoring.'' FOR FURTHER INFORMATION...

Orange-red emitting Gd2Zr2O7:Sm3+: Structure-property correlation, optical properties and defect spectroscopy

NASA Astrophysics Data System (ADS)

Gupta, Santosh K.; Reghukumar, C.; Sudarshan, K.; Ghosh, P. S.; Pathak, Nimai; Kadam, R. M.

2018-05-01

Local structure analysis of dopant ion, understanding host to dopant energy transfer dynamics and defects characterization in a doped material which plays an important role in the designing a highly efficient opto-electronic material. In this connection a new Sm3+ doped Gd2Zr2O7 pyrochlore material was synthesized using gel-combustion technique and was characterized systematically using X-ray diffraction (XRD), time resolved photoluminescence spectroscopy (TRPLS), positron annihilation lifetime spectroscopy (PALS) and density functional theory (DFT) based ab-initio calculation. Based on DFT site selective energetics calculation and luminescence decay measurement, it was observed that the Sm3+ was distributed at both Gd3+ and Zr4+ site with higher Sm3+ fraction at the Gd3+ site. PALS was used to probe the presence of defects in the phosphor. In this work intense orange-red emission is realized through manipulating the energy transfer from host defect emission (oxygen vacancies) to Sm3+ which allows color emission from green in undoped to orange-red in doped samples. Effect of dopant concentration and annealing temperature was probed using TRPLS and PALS. These all information is highly important for researcher looking to achieve pyrochlore based phosphor materials with high quantum yield.

Crystal structure of phototoxic orange fluorescent proteins with α tryptophan-based chromophore

DOE PAGES

Pletneva, Nadya V.; Pletnev, Vladimir Z.; Sarkisyan, Karen S.; ...

2015-12-23

Phototoxic fluorescent proteins represent a sparse group of genetically encoded photosensitizers that could be used for precise light-induced inactivation of target proteins, DNA damage, and cell killing. Only two such GFP-based fluorescent proteins (FPs), KillerRed and its monomeric variant SuperNova, were described up to date. We present a crystallographic study of their two orange successors, dimeric KillerOrange and monomeric mKiller-Orange, at 1.81 and 1.57 Å resolution, respectively. They are the first orange-emitting protein photosensitizers with a tryptophan-based chromophore (Gln65-Trp66-Gly67). Same as their red progenitors, both orange photosensitizers have a water-filled channel connecting the chromophore to the β-barrel exterior and enablingmore » transport of ROS. In both proteins, Trp66 of the chromophore adopts an unusual trans-cis conformation stabilized by H-bond with the nearby Gln159. This trans-cis conformation along with the water channel was shown to be a key structural feature providing bright orange emission and phototoxicity of both examined orange photosensitizers.« less

Crystal Structure of Phototoxic Orange Fluorescent Proteins with a Tryptophan-Based Chromophore

PubMed Central

Pletneva, Nadya V.; Pletnev, Vladimir Z.; Sarkisyan, Karen S.; Gorbachev, Dmitry A.; Egorov, Evgeny S.; Mishin, Alexander S.; Lukyanov, Konstantin A.; Dauter, Zbigniew; Pletnev, Sergei

2015-01-01

Phototoxic fluorescent proteins represent a sparse group of genetically encoded photosensitizers that could be used for precise light-induced inactivation of target proteins, DNA damage, and cell killing. Only two such GFP-based fluorescent proteins (FPs), KillerRed and its monomeric variant SuperNova, were described up to date. Here, we present a crystallographic study of their two orange successors, dimeric KillerOrange and monomeric mKillerOrange, at 1.81 and 1.57 Å resolution, respectively. They are the first orange-emitting protein photosensitizers with a tryptophan-based chromophore (Gln65-Trp66-Gly67). Same as their red progenitors, both orange photosensitizers have a water-filled channel connecting the chromophore to the β-barrel exterior and enabling transport of ROS. In both proteins, Trp66 of the chromophore adopts an unusual trans-cis conformation stabilized by H-bond with the nearby Gln159. This trans-cis conformation along with the water channel was shown to be a key structural feature providing bright orange emission and phototoxicity of both examined orange photosensitizers. PMID:26699366

Literacy and Development for the Orang Asli in Malaysia: What Matters?

ERIC Educational Resources Information Center

Renganathan, Sumathi

2016-01-01

This article explores the literacy practices of the indigenous Semai Orang Asli community in Malaysia. Literacy for the Orang Asli often centres on formal education and schooling and is hardly explored from a social and cultural perspective. In fact, researchers have paid barely any attention to Orang Asli oral and literate traditions nor their…

HIGH PREVALENCE OF AGENT ORANGE EXPOSURE AMONG THYROID CANCER PATIENTS IN THE NATIONAL VA HEALTHCARE SYSTEM.

PubMed

Le, Karen T; Sawicki, Mark P; Wang, Marilene B; Hershman, Jerome M; Leung, Angela M

2016-06-01

Thyroid cancer is the most common endocrine malignancy and the most rapidly increasing cancer in the U.S. Little is known regarding the epidemiology and characteristics of patients with thyroid cancer within the national Veterans Health Administration (VHA) integrated healthcare system. The aim of this study was to further understand the characteristics of thyroid cancer patients in the VHA population, particularly in relation to Agent Orange exposure. This is a descriptive analysis of the VA (Veterans Affairs) Corporate Data Warehouse database from all U.S. VHA healthcare sites from October1, 1999, to December 31, 2013. Information was extracted for all thyroid cancer patients based on International Classification of Diseases-ninth revision diagnosis codes; histologic subtypes of thyroid cancer were not available. There were 19,592 patients (86% men, 76% white, 58% married, 42% Vietnam-era Veteran) in the VHA system with a diagnosis of thyroid cancer within this 14-year study period. The gender-stratified prevalence rates of thyroid cancer among the Veteran population during the study period were 1:1,114 (women) and 1:1,023 (men), which were lower for women but similar for men, when compared to the U.S. general population in 2011 (1:350 for women and 1:1,219 for men). There was a significantly higher proportion of self-reported Agent Orange exposure among thyroid cancer patients (10.0%), compared to the general VHA population (6.2%) (P<.0001). Thyroid cancer patients, in this sample, have a higher prevalence of self-reported Agent Orange exposure compared to the overall national VA patient population. T4 = thyroxine TCDD = 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin TSH = thyroid-stimulating hormone VA = Veterans Affairs VHA = Veterans Health Administration.

Developing county bridge repair and retrofit techniques.

DOT National Transportation Integrated Search

2013-08-01

Oklahoma rated first in the Nation in the percentage of bridges that are structurally deficient or : functionally obsolete. According to Federal Highway Administration data, Oklahoma uses : approximately 23,250 bridges maintained by state, County, Ci...

Ultrastructural changes in sweet orange with symptoms of huanglongbing

USDA-ARS?s Scientific Manuscript database

Citrus greening (Huanglongbing [HLB]) is one of the most destructive citrus diseases worldwide. To better understand the ultrastructural changes of sweet orange seedlings in response to infection, anatomical analyses of HLB-infected sweet orange were carried out by light and electron microscopy. A...

[Health protection and health promotion in formal structures of executive county authorities and executive offices of municipalities having the county status].

PubMed

Nosko, Jan; Marcinkiewicz, Andrzej

2009-01-01

An analysis of the role of public administration in the Polish health system, essential for the effectiveness of health protection and health promotion, is a very important and urgent task faced by scholars. This issue also concerns the authorities of counties (powiaty) and municipalities having the county status (MHCS), and these structures were chosen as the subject of our study. The aim of the study was to analyze whether health related rules and regulations of these administrative structures comply with the requirements of relevant Polish legislation acts. The survey, performed in 2008, covered all the 378 counties and municipalities having the county status. On the basis of 171 Acts reviewed, a list of 11 groups of obligations and duties assigned to county and municipality units were prepared and used as a research tool. It was found that the provisions of the Health Care Institutions Act of 1991 were most evidently (87%) reflected in the rules and regulations of the studies structures; more than a half (57%) refer to prophylaxis and health promotion, however, the most important Act as far as health protection and health promotion are concerned, i.e., the Act of 2004 was reflected in only 11.6%. Also the presence of some outdated regulations was discovered. The results of the study may indicate that the mechanisms, by which the execution of legal regulations on health protection and health promotion tasks should be supervised, are insufficient.

5 CFR 1320.15 - Independent regulatory agency override authority.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Independent regulatory agency override authority. 1320.15 Section 1320.15 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES CONTROLLING PAPERWORK BURDENS ON THE PUBLIC § 1320.15 Independent regulatory agency override authority. (a) An...

EDTA aggregates induce SYPRO orange-based fluorescence in thermal shift assay

PubMed Central

Kroeger, Tobias; Frieg, Benedikt; Zhang, Tao; Hansen, Finn K.; Marmann, Andreas; Proksch, Peter; Nagel-Steger, Luitgard; Groth, Georg; Smits, Sander H. J.

2017-01-01

Ethylenediaminetetraacetic acid (EDTA) is widely used in the life sciences as chelating ligand of metal ions. However, formation of supramolecular EDTA aggregates at pH > 8 has been reported, which may lead to artifactual assay results. When applied as a buffer component at pH ≈ 10 in differential scanning fluorimetry (TSA) using SYPRO Orange as fluorescent dye, we observed a sharp change in fluorescence intensity about 20°C lower than expected for the investigated protein. We hypothesized that this change results from SYPRO Orange/EDTA interactions. TSA experiments in the presence of SYPRO Orange using solutions that contain EDTA-Na+ but no protein were performed. The TSA experiments provide evidence that suggests that at pH > 9, EDTA4- interacts with SYPRO Orange in a temperature-dependent manner, leading to a fluorescence signal yielding a “denaturation temperature” of ~68°C. Titrating Ca2+ to SYPRO Orange and EDTA solutions quenched fluorescence. Ethylene glycol tetraacetic acid (EGTA) behaved similarly to EDTA. Analytical ultracentrifugation corroborated the formation of EDTA aggregates. Molecular dynamics simulations of free diffusion of EDTA-Na+ and SYPRO Orange of in total 27 μs suggested the first structural model of EDTA aggregates in which U-shaped EDTA4- arrange in an inverse bilayer-like manner, exposing ethylene moieties to the solvent, with which SYPRO Orange interacts. We conclude that EDTA aggregates induce a SYPRO Orange-based fluorescence in TSA. These results make it relevant to ascertain that future TSA results are not influenced by interference between EDTA, or EDTA-related molecules, and the fluorescent dye. PMID:28472107

Pharmacokinetics of flavanone glycosides after ingestion of single doses of fresh-squeezed orange juice versus commercially processed orange juice in healthy humans

USDA-ARS?s Scientific Manuscript database

Orange juice is a rich source of flavonoids known to be beneficial to cardiovascular health in humans. The objective of this study was to analyze the pharmacokinetics of the main flavanone glycosides, hesperidin and narirutin, in humans after the consumption of two types of orange juice, fresh squee...

4. DETAIL VIEW OF ADMINISTRATION BUILDING SHOWING WEST FACADE. VIEW ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. DETAIL VIEW OF ADMINISTRATION BUILDING SHOWING WEST FACADE. VIEW TO NORTHEAST. - VA Medical Center, Aspinwall Division, Administration Building, 5103 Delafield Avenue, Aspinwall, Allegheny County, PA

78 FR 38053 - Regulatory Systems Strengthening

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-25

... Science Policy Analysis/Office of International Programs, HFG-1, Food and Drug Administration, 10903 New... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0010] Regulatory Systems Strengthening AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food...

Meat-eating by a wild Bornean orang-utan (Pongo pygmaeus).

PubMed

Buckley, Benjamin J W; Dench, Rosalie J; Morrogh-Bernard, Helen C; Bustani, Unyil; Chivers, David J

2015-10-01

We present the first evidence for consumption of meat by a wild Bornean orang-utan (Pongo pygmaeus). Meat-eating has been reported in Sumatran orang-utans, specifically the hunting and consumption of slow lorises (Nycticebus coucang), but loris-hunting behaviour has not been observed in the Bornean species and meat of any species is essentially absent from their diet, with only two anecdotal reports of vertebrate meat consumption prior to this current finding in over 40 years of study. In August 2012 an unhabituated adult flanged male orang-utan was observed eating an adult horse-tailed squirrel (Sundasciurus hippurus) carcass in the Sabangau peat-swamp forest, Central Kalimantan. We suspect this to be a case of scavenging, never reported previously in a Bornean orang-utan.

A successful turnaround in Dade County

DOE Office of Scientific and Technical Information (OSTI.GOV)

Frank, H.

1988-10-01

When Dade County, Fla., decided to build a waste-to-energy plant, little did it known what a stink it would bring. Odor problems and seagulls plagued the neighborhood, emissions exceeded regulatory standards, and wind-blown garbage littered the facility. Maintenance costs rose and electricity sales never came close to its rated capacity. The residents called for a change, and they got it. After a new operator took over the plant, some of the problems were quickly solved. Other problems, which required substantial capital improvements to solve, were clearly identified. And after Dade County approved a new contract with $45 million in improvements,more » the facility is back on track to meeting the community's needs in an acceptable manner. The paper describes the original plant design, early problems, improved operation, present plant operation, and the Plant Rehabilitation Program.« less

8. PHOTOCOPY, HEATING DRAWING FOR ADMINISTRATION BUILDING. NIKE Missile ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. PHOTOCOPY, HEATING DRAWING FOR ADMINISTRATION BUILDING. - NIKE Missile Base SL-40, Administration Building, East central portion of base, southeast of Mess Hall, northeast of HIPAR Equipment Building, Hecker, Monroe County, IL

1. ADMINISTRATION BUILDING, RIGHT SIDE, LOOKING SOUTH. NIKE Missile ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. ADMINISTRATION BUILDING, RIGHT SIDE, LOOKING SOUTH. - NIKE Missile Base SL-40, Administration Building, East central portion of base, southeast of Mess Hall, northeast of HIPAR Equipment Building, Hecker, Monroe County, IL

7. PHOTOCOPY, ELEVATION DRAWING OF ADMINISTRATION BUILDING. NIKE Missile ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. PHOTOCOPY, ELEVATION DRAWING OF ADMINISTRATION BUILDING. - NIKE Missile Base SL-40, Administration Building, East central portion of base, southeast of Mess Hall, northeast of HIPAR Equipment Building, Hecker, Monroe County, IL

2. ADMINISTRATION BUILDING, REAR SIDE, LOOKING EAST. NIKE Missile ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. ADMINISTRATION BUILDING, REAR SIDE, LOOKING EAST. - NIKE Missile Base SL-40, Administration Building, East central portion of base, southeast of Mess Hall, northeast of HIPAR Equipment Building, Hecker, Monroe County, IL

3. ADMINISTRATION BUILDING, LEFT SIDE, LOOKING NORTH. NIKE Missile ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. ADMINISTRATION BUILDING, LEFT SIDE, LOOKING NORTH. - NIKE Missile Base SL-40, Administration Building, East central portion of base, southeast of Mess Hall, northeast of HIPAR Equipment Building, Hecker, Monroe County, IL

A FRET-facilitated photoswitching using an orange fluorescent protein with the fast photoconversion kinetics.

PubMed

Subach, Oksana M; Entenberg, David; Condeelis, John S; Verkhusha, Vladislav V

2012-09-12

Fluorescent proteins photoswitchable with noncytotoxic light irradiation and spectrally distinct from multiple available photoconvertible green-to-red probes are in high demand. We have developed a monomeric fluorescent protein, called PSmOrange2, which is photoswitchable with blue light from an orange (ex./em. at 546 nm/561 nm) to a far-red (ex./em. at 619 nm/651 nm) form. Compared to another orange-to-far-red photoconvertable variant, PSmOrange2 has blue-shifted photoswitching action spectrum, 9-fold higher photoconversion contrast, and up to 10-fold faster photoswitching kinetics. This results in the 4-fold more PSmOrange2 molecules being photoconverted in mammalian cells. Compared to common orange fluorescent proteins, such as mOrange, the orange form of PSmOrange has substantially higher photostability allowing its use in multicolor imaging applications to track dynamics of multiple populations of intracellular objects. The PSmOrange2 photochemical properties allow its efficient photoswitching with common two-photon lasers and, moreover, via Förster resonance energy transfer (FRET) from green fluorescent donors. We have termed the latter effect a FRET-facilitated photoswitching and demonstrated it using several sets of interacting proteins. The enhanced photoswitching properties of PSmOrange2 make it a superior photoconvertable protein tag for flow cytometry, conventional microscopy, and two-photon imaging of live cells.

Application of the industrial hygiene hierarchy of controls to prioritize and promote safer methods of pest control: a case study.

PubMed

Weinberg, Justine Lew; Bunin, Lisa J; Das, Rupali

2009-01-01

In 2005, the California Department of Public Health, Occupational Health Branch (OHB) investigated an incident of pesticide exposure and identified 27 vineyard workers who became ill due to drift of cyfluthrin, a pesticide being applied to a neighboring orange field to control katydids. Another pest, citrus thrips, was also present in the field. We investigated safer alternatives for katydid and thrips control to prevent illness due to pesticide exposure and used the industrial hygiene hierarchy of controls to prioritize the control methods. OHB evaluated factors that contributed to pesticide exposure and identified safer alternatives by conducting literature reviews on katydid and thrips control, drift prevention technology, and other relevant topics, and by interviewing integrated pest management advisors, conventional and organic growers, equipment manufacturers, county agricultural commissioners, pest control advisors, regulatory agencies, and others. We prioritized methods using the industrial hygiene hierarchy of controls. We identified safer pest control practices that incorporated hazard elimination, chemical substitution, engineering controls, and administrative controls, including employer policies and government regulations.

5 CFR 340.201 - Regulatory requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 340.201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS OTHER THAN FULL-TIME CAREER EMPLOYMENT (PART-TIME, SEASONAL, ON-CALL, AND INTERMITTENT) Regulatory Requirements-Part-Time Employment § 340.201 Regulatory requirements. This subpart contains the regulations of the...

5. DETAIL VIEW OF ADMINISTRATION BUILDING SHOWING PRINCIPAL, EAST, ENTRY. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. DETAIL VIEW OF ADMINISTRATION BUILDING SHOWING PRINCIPAL, EAST, ENTRY. VIEW TO WEST. - VA Medical Center, Aspinwall Division, Administration Building, 5103 Delafield Avenue, Aspinwall, Allegheny County, PA

8. DETAIL VIEW OF ADMINISTRATION BUILDING. INTERIOR VIEW SHOWING VESTIBULE. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. DETAIL VIEW OF ADMINISTRATION BUILDING. INTERIOR VIEW SHOWING VESTIBULE. VIEW TO WEST. - VA Medical Center, Aspinwall Division, Administration Building, 5103 Delafield Avenue, Aspinwall, Allegheny County, PA

6. ADMINISTRATION BUILDING WITH FLAG POLE, LOOKING SOUTH. NIKE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. ADMINISTRATION BUILDING WITH FLAG POLE, LOOKING SOUTH. - NIKE Missile Base SL-40, Administration Building, East central portion of base, southeast of Mess Hall, northeast of HIPAR Equipment Building, Hecker, Monroe County, IL

21 CFR 74.2260 - D&C Orange No. 10.

Code of Federal Regulations, 2010 CFR

2010-04-01

... COLOR ADDITIVES SUBJECT TO CERTIFICATION Cosmetics § 74.2260 D&C Orange No. 10. (a) Identity and specifications. The color additive D&C Orange No. 10 shall conform in identity and specifications to the... coloring externally applied cosmetics in amounts consistent with good manufacturing practice. (c) Labeling...

21 CFR 74.2261 - D&C Orange No. 11.

Code of Federal Regulations, 2010 CFR

2010-04-01

... COLOR ADDITIVES SUBJECT TO CERTIFICATION Cosmetics § 74.2261 D&C Orange No. 11. (a) Identity and specifications. The color additive D&C Orange No. 11 shall conform in identity and specifications to the... coloring externally applied cosmetics in amounts consistent with good manufacturing practice. (c) Labeling...

21 CFR 74.2254 - D&C Orange No. 4.

Code of Federal Regulations, 2010 CFR

2010-04-01

... ADDITIVES SUBJECT TO CERTIFICATION Cosmetics § 74.2254 D&C Orange No. 4. (a) Identity and specifications. The color additive D&C Orange No. 4 shall conform in identity and specifications to the requirements... coloring externally applied cosmetics in amounts consistent with good manufacturing practice. (c) Labeling...

21 CFR 74.2254 - D&C Orange No. 4.

Code of Federal Regulations, 2012 CFR

2012-04-01

... ADDITIVES SUBJECT TO CERTIFICATION Cosmetics § 74.2254 D&C Orange No. 4. (a) Identity and specifications. The color additive D&C Orange No. 4 shall conform in identity and specifications to the requirements... coloring externally applied cosmetics in amounts consistent with good manufacturing practice. (c) Labeling...

21 CFR 74.2260 - D&C Orange No. 10.

Code of Federal Regulations, 2013 CFR

2013-04-01

... COLOR ADDITIVES SUBJECT TO CERTIFICATION Cosmetics § 74.2260 D&C Orange No. 10. (a) Identity and specifications. The color additive D&C Orange No. 10 shall conform in identity and specifications to the... coloring externally applied cosmetics in amounts consistent with good manufacturing practice. (c) Labeling...

21 CFR 74.2260 - D&C Orange No. 10.

Code of Federal Regulations, 2012 CFR

2012-04-01

... COLOR ADDITIVES SUBJECT TO CERTIFICATION Cosmetics § 74.2260 D&C Orange No. 10. (a) Identity and specifications. The color additive D&C Orange No. 10 shall conform in identity and specifications to the... coloring externally applied cosmetics in amounts consistent with good manufacturing practice. (c) Labeling...

21 CFR 74.2261 - D&C Orange No. 11.

Code of Federal Regulations, 2014 CFR

2014-04-01

... COLOR ADDITIVES SUBJECT TO CERTIFICATION Cosmetics § 74.2261 D&C Orange No. 11. (a) Identity and specifications. The color additive D&C Orange No. 11 shall conform in identity and specifications to the... coloring externally applied cosmetics in amounts consistent with good manufacturing practice. (c) Labeling...

21 CFR 74.2261 - D&C Orange No. 11.

Code of Federal Regulations, 2013 CFR

2013-04-01

... COLOR ADDITIVES SUBJECT TO CERTIFICATION Cosmetics § 74.2261 D&C Orange No. 11. (a) Identity and specifications. The color additive D&C Orange No. 11 shall conform in identity and specifications to the... coloring externally applied cosmetics in amounts consistent with good manufacturing practice. (c) Labeling...

21 CFR 74.2254 - D&C Orange No. 4.

Code of Federal Regulations, 2013 CFR

2013-04-01

... ADDITIVES SUBJECT TO CERTIFICATION Cosmetics § 74.2254 D&C Orange No. 4. (a) Identity and specifications. The color additive D&C Orange No. 4 shall conform in identity and specifications to the requirements... coloring externally applied cosmetics in amounts consistent with good manufacturing practice. (c) Labeling...

21 CFR 74.2260 - D&C Orange No. 10.

Code of Federal Regulations, 2014 CFR

2014-04-01

... COLOR ADDITIVES SUBJECT TO CERTIFICATION Cosmetics § 74.2260 D&C Orange No. 10. (a) Identity and specifications. The color additive D&C Orange No. 10 shall conform in identity and specifications to the... coloring externally applied cosmetics in amounts consistent with good manufacturing practice. (c) Labeling...

21 CFR 74.2261 - D&C Orange No. 11.

Code of Federal Regulations, 2012 CFR

2012-04-01

... COLOR ADDITIVES SUBJECT TO CERTIFICATION Cosmetics § 74.2261 D&C Orange No. 11. (a) Identity and specifications. The color additive D&C Orange No. 11 shall conform in identity and specifications to the... coloring externally applied cosmetics in amounts consistent with good manufacturing practice. (c) Labeling...

21 CFR 74.2254 - D&C Orange No. 4.

Code of Federal Regulations, 2014 CFR

2014-04-01

... ADDITIVES SUBJECT TO CERTIFICATION Cosmetics § 74.2254 D&C Orange No. 4. (a) Identity and specifications. The color additive D&C Orange No. 4 shall conform in identity and specifications to the requirements... coloring externally applied cosmetics in amounts consistent with good manufacturing practice. (c) Labeling...

Decoding the Nonvolatile Sensometabolome of Orange Juice ( Citrus sinensis).

PubMed

Glabasnia, Anneke; Dunkel, Andreas; Frank, Oliver; Hofmann, Thomas

2018-03-14

Activity-guided fractionation in combination with the taste dilution analysis, followed by liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, led to the identification of 10 polymethoxylated flavones (PMFs), 6 limonoid glucosides, and 2 limonoid aglycones as the key bitterns of orange juice. Quantitative studies and calculation of dose-over-threshold factors, followed by taste re-engineering, demonstrated for the first time 25 sensometabolites to be sufficient to reconstruct the typical taste profile of orange juices and indicated that not a single compound can be considered a suitable marker for juice bitterness. Intriguingly, the taste percept of orange juice seems to be created by a rather complex interplay of limonin, limonoid glucosides, PMFs, organic acids, and sugars. For the first time, sub-threshold concentrations of PMFs were shown to enhance the perceived bitterness of limonoids. Moreover, the influence of sugars on the perceived bitterness of limonoids and PMFs in orange juice relevant concentration ranges was quantitatively elucidated.

Citric Acid Production from Orange Peel Wastes by Solid-State Fermentation

PubMed Central

Torrado, Ana María; Cortés, Sandra; Manuel Salgado, José; Max, Belén; Rodríguez, Noelia; Bibbins, Belinda P.; Converti, Attilio; Manuel Domínguez, José

2011-01-01

Valencia orange (Citrus sinensis) peel was employed in this work as raw material for the production of citric acid (CA) by solid-state fermentation (SSF) of Aspergillus niger CECT-2090 (ATCC 9142, NRRL 599) in Erlenmeyer flasks. To investigate the effects of the main operating variables, the inoculum concentration was varied in the range 0.5·103 to 0.7·108 spores/g dry orange peel, the bed loading from 1.0 to 4.8 g of dry orange peel (corresponding to 35-80 % of the total volume), and the moisture content between 50 and 100 % of the maximum water retention capacity (MWRC) of the material. Moreover, additional experiments were done adding methanol or water in different proportions and ways. The optimal conditions for CA production revealed to be an inoculum of 0.5·106 spores/g dry orange peel, a bed loading of 1.0 g of dry orange peel, and a humidification pattern of 70 % MWRC at the beginning of the incubation with posterior addition of 0.12 mL H2O/g dry orange peel (corresponding to 3.3 % of the MWRC) every 12 h starting from 62 h. The addition of methanol was detrimental for the CA production. Under these conditions, the SSF ensured an effective specific production of CA (193 mg CA/g dry orange peel), corresponding to yields of product on total initial and consumed sugars (glucose, fructose and sucrose) of 376 and 383 mg CA/g, respectively. These results, which demonstrate the viability of the CA production by SSF from orange peel without addition of other nutrients, could be of interest to possible, future industrial applications. PMID:24031646

2. DETAIL VIEW OF ADMINISTRATION BUILDING SHOWING EAST AND NORTH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. DETAIL VIEW OF ADMINISTRATION BUILDING SHOWING EAST AND NORTH FACADES. VIEW TO SOUTHWEST. - VA Medical Center, Aspinwall Division, Administration Building, 5103 Delafield Avenue, Aspinwall, Allegheny County, PA

Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016.

PubMed

Vostal, Jaroslav G; Buehler, Paul W; Gelderman, Monique P; Alayash, Abdu I; Doctor, Alan; Zimring, James C; Glynn, Simone A; Hess, John R; Klein, Harvey; Acker, Jason P; Spinella, Philip C; D'Alessandro, Angelo; Palsson, Bernhard; Raife, Thomas J; Busch, Michael P; McMahon, Timothy J; Intaglietta, Marcos; Swartz, Harold M; Dubick, Michael A; Cardin, Sylvain; Patel, Rakesh P; Natanson, Charles; Weisel, John W; Muszynski, Jennifer A; Norris, Philip J; Ness, Paul M

2018-01-01

The US Food and Drug Administration (FDA) held a workshop on red blood cell (RBC) product regulatory science on October 6 and 7, 2016, at the Natcher Conference Center on the National Institutes of Health (NIH) Campus in Bethesda, Maryland. The workshop was supported by the National Heart, Lung, and Blood Institute, NIH; the Department of Defense; the Office of the Assistant Secretary for Health, Department of Health and Human Services; and the Center for Biologics Evaluation and Research, FDA. The workshop reviewed the status and scientific basis of the current regulatory framework and the available scientific tools to expand it to evaluate innovative and future RBC transfusion products. A full record of the proceedings is available on the FDA website (http://www.fda.gov/BiologicsBloodVaccines/NewsEvents/WorkshopsMeetingsConferences/ucm507890.htm). The contents of the summary are the authors' opinions and do not represent agency policy. © 2017 AABB.

Effect of ultrahigh-temperature continuous ohmic heating treatment on fresh orange juice.

PubMed

Leizerson, Shirly; Shimoni, Eyal

2005-05-04

The scope of this study is the effect of ohmic heating thermal treatment on liquid fruit juice made of oranges. Effects of ohmic heating on the quality of orange juice were examined and compared to those of heat pasteurization at 90 degrees C for 50 s. Orange juice was treated at temperatures of 90, 120, and 150 degrees C for 1.13, 0.85, and 0.68 s in an ohmic heating system. Microbial counts showed complete inactivation of bacteria, yeast, and mold during ohmic and conventional treatments. The ohmic heating treatment reduced pectin esterase activity by 98%. The reduction in vitamin C was 15%. Ohmic-heated orange juice maintained higher amounts of the five representative flavor compounds than did heat-pasteurized juice. Sensory evaluation tests showed no difference between fresh and ohmic-heated orange juice. Thus, high-temperature ohmic-heating treatment can be effectively used to pasteurize fresh orange juice with minimal sensory deterioration.

9. PHOTOCOPY, FOUNDATION AND FLOORING PLANS FOR ADMINISTRATION BUILDING. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. PHOTOCOPY, FOUNDATION AND FLOORING PLANS FOR ADMINISTRATION BUILDING. - NIKE Missile Base SL-40, Administration Building, East central portion of base, southeast of Mess Hall, northeast of HIPAR Equipment Building, Hecker, Monroe County, IL

5. ADMINISTRATION BUILDING, RIGHT AND LEFT SIDES, LOOKING NORTHEAST. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. ADMINISTRATION BUILDING, RIGHT AND LEFT SIDES, LOOKING NORTHEAST. - NIKE Missile Base SL-40, Administration Building, East central portion of base, southeast of Mess Hall, northeast of HIPAR Equipment Building, Hecker, Monroe County, IL

4. ADMINISTRATION BUILDING, FRONT AND RIGHT SIDES, LOOKING SOUTHWEST. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. ADMINISTRATION BUILDING, FRONT AND RIGHT SIDES, LOOKING SOUTHWEST. - NIKE Missile Base SL-40, Administration Building, East central portion of base, southeast of Mess Hall, northeast of HIPAR Equipment Building, Hecker, Monroe County, IL

7 CFR 7.9 - Election of community committee members, delegates to local administrative area and county...

Code of Federal Regulations, 2010 CFR

2010-01-01

... may authorize use of the meeting or polling place method in a specific county where such is deemed justified. Where elections are by mail or by polling place, the county committee shall give advance public...

10. DETAIL VIEW OF ADMINISTRATION BUILDING. INTERIOR VIEW SHOWING SECOND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. DETAIL VIEW OF ADMINISTRATION BUILDING. INTERIOR VIEW SHOWING SECOND FLOOR CORRIDOR. VIEW TO NORTH. - VA Medical Center, Aspinwall Division, Administration Building, 5103 Delafield Avenue, Aspinwall, Allegheny County, PA

9. DETAIL VIEW OF ADMINISTRATION BUILDING. INTERIOR VIEW SHOWING FIRST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. DETAIL VIEW OF ADMINISTRATION BUILDING. INTERIOR VIEW SHOWING FIRST FLOOR CORRIDOR. VIEW TO SOUTH. - VA Medical Center, Aspinwall Division, Administration Building, 5103 Delafield Avenue, Aspinwall, Allegheny County, PA

Orange juice (poly)phenols are highly bioavailable in humans.

PubMed

Pereira-Caro, Gema; Borges, Gina; van der Hooft, Justin; Clifford, Michael N; Del Rio, Daniele; Lean, Michael E J; Roberts, Susan A; Kellerhals, Michele B; Crozier, Alan

2014-11-01

We assessed the bioavailability of orange juice (poly)phenols by monitoring urinary flavanone metabolites and ring fission catabolites produced by the action of the colonic microbiota. Our objective was to identify and quantify metabolites and catabolites excreted in urine 0-24 h after the acute ingestion of a (poly)phenol-rich orange juice by 12 volunteers. Twelve volunteers [6 men and 6 women; body mass index (in kg/m(2)): 23.9-37.2] consumed a low (poly)phenol diet for 2 d before first drinking 250 mL pulp-enriched orange juice, which contained 584 μmol (poly)phenols of which 537 μmol were flavanones, and after a 2-wk washout, the procedure was repeated, and a placebo drink was consumed. Urine collected for a 24-h period was analyzed qualitatively and quantitatively by using high-performance liquid chromatography-mass spectrometry (HPLC-MS) and gas chromatography-mass spectrometry (GC-MS). A total of 14 metabolites were identified and quantified in urine by using HPLC-MS after orange juice intake. Hesperetin-O-glucuronides, naringenin-O-glucuronides, and hesperetin-3'-O-sulfate were the main metabolites. The overall urinary excretion of flavanone metabolites corresponded to 16% of the intake of 584 μmol (poly)phenols. The GC-MS analysis revealed that 8 urinary catabolites were also excreted in significantly higher quantities after orange juice consumption. These catabolites were 3-(3'-methoxy-4'-hydroxyphenyl)propionic acid, 3-(3'-hydroxy-4'-methoxyphenyl)propionic acid, 3-(3'-hydroxy-4'-methoxyphenyl)hydracrylic acid, 3-(3'-hydroxyphenyl)hydracrylic acid, 3'-methoxy-4'-hydroxyphenylacetic acid, hippuric acid, 3'-hydroxyhippuric acid, and 4'-hydroxyhippuric acid. These aromatic acids originated from the colonic microbiota-mediated breakdown of orange juice (poly)phenols and were excreted in amounts equivalent to 88% of (poly)phenol intake. When combined with the 16% excretion of metabolites, this percentage raised the overall urinary excretion to ∼ 100% of

7. DETAIL VIEW OF ADMINISTRATION BUILDING. INTERIOR VIEW SHOWING VESTIBULE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. DETAIL VIEW OF ADMINISTRATION BUILDING. INTERIOR VIEW SHOWING VESTIBULE AND COPY ROOM. VIEW TO EAST. - VA Medical Center, Aspinwall Division, Administration Building, 5103 Delafield Avenue, Aspinwall, Allegheny County, PA

78 FR 54147 - Domestic Dates Produced or Packed in Riverside County, California; Decreased Assessment Rate

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-03

... Executive Order 12988, Civil Justice Reform. Under the marketing order now in effect, Riverside County... contains regulatory documents #0;having general applicability and legal effect, most of which are keyed #0... 54147

Study of flavour compounds from orange juices by HS-SPME and GC-MS

NASA Astrophysics Data System (ADS)

Schmutzer, G.; Avram, V.; Covaciu, F.; Feher, I.; Magdas, A.; David, L.; Moldovan, Z.

2013-11-01

The flavour of the orange juices, which gives the taste and odour of the product, is an important criterion about the products quality for consumers. A fresh single strength and two commercial orange juices (obtained from concentrate) flavour profile were studied using a selective and sensitive gas chromatography - mass spectrometry (GC-MS) analytical system, after a solvent free, single step preconcentration and extraction technique, the headspace solid phase microextraction (HP-SPME). In the studied orange juices 55 flavour compounds were detected and classified as belonging to the esters, alcohols, ketones, monoterpenes and sesquiterpenes chemical families. The fresh single strength orange juice was characterized by high amount of esters, monoterpenes and sesquiterpenes. Limonene and valencene were the most abundant flavours in this fresh natural orange juice. Alcohols and ketones were found in higher concentration in the commercial orange juices made from concentrate, than in the single strength products. Nevertheless, in commercial juices the most abundant flavour was limonene and α-terpineol. The results highlight clear differences between fresh singles strength orange juice and juice from concentrate. The orange juices reconstructed from concentrate, made in Romania, present low quantity of flavour compounds, suggesting the absence or a low rearomatization process, but extraneous components were not detected.

Study of the absorption spectra of Fricke Xylenol Orange gel dosimeters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gambarini, Grazia; Artuso, Emanuele; Liosi, Giulia Maria

2015-07-01

A systematic study of the absorption spectra of Fricke Xylenol Orange gel dosimeters has been performed, in the wavelength range from 300 nm to 700 nm. The spectrum of Xylenol Orange (without ferrous sulphate solution) has been achieved, in order to subtract its contribution from the absorption spectra of the irradiated Fricke Xylenol Orange gel dosimeters. The absorbance due to ferric ions chelated by Xylenol Orange has been studied for various irradiation doses. Two absorbance peaks are visible, mainly at low doses: the first peak increases with the dose more slowly than the second one. This effect can explain themore » apparent threshold dose that was frequently evidenced. (authors)« less

11. DETAIL VIEW OF ADMINISTRATION BUILDING. INTERIOR VIEW ON SECOND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. DETAIL VIEW OF ADMINISTRATION BUILDING. INTERIOR VIEW ON SECOND FLOOR SHOWING TYPICAL OFFICE. VIEW TO NORTHWEST. - VA Medical Center, Aspinwall Division, Administration Building, 5103 Delafield Avenue, Aspinwall, Allegheny County, PA

Synthesis and Luminescence Properties of Orange-Red Phosphors Na Y (WO4)2: Eu3+, Sm3+

NASA Astrophysics Data System (ADS)

Yu, Hong; Chen, Shanyong; Chen, Jinlei

2017-12-01

Orange-red phosphors NaY(WO4)2:Eu3+, Sm3+ were successfully synthesised by hydrothermal synthesis method. The photoluminescence (PL) properties were investigated. The PL emission spectrum of Na Y (WO4)2: Eu3+ shows good luminous properties under 398 nm, which mainly located at 596 and 615 nm, with the additional of Sm3+ could broaden and increase emission intensity of Eu3+, which could be suitable for the excitation of UV light emitting diodes (LEDs) (∼400 nm). The PL results indicated that Na Y (WO4)2: Eu3+, Sm3+ may be a promising red phosphor candidate for use in white LEDs.

Antioxidant effectiveness of organically and non-organically grown red oranges in cell culture systems.

PubMed

Tarozzi, A; Hrelia, S; Angeloni, C; Morroni, F; Biagi, P; Guardigli, M; Cantelli-Forti, G; Hrelia, P

2006-03-01

Consumers consider plant food products from organic origin healthier than the corresponding conventional plant foods. Clear experimental evidence supporting this assumption is still lacking. To determine if the organic red oranges have a higher phyto-chemical content (i. e., phenolics, anthocyanins and ascorbic acid), total antioxidant activity and in vitro bioactivity, in terms of protective effect against oxidative damage at cellular level, than nonorganic red oranges. Total phenolics were measured using the Folin Ciocalteau assay, while total anthocyanins and ascorbic acid levels were determined by spectrophotometric and HPLC analysis, respectively. In addition, the total antioxidant activity of red orange extracts was measured by the ABTS(*+) test. The ability of red orange extracts to counteract conjugated diene containing lipids and free radical production in cultured rat cardiomyocytes and differentiated Caco-2 cells, respectively, was assessed. Organic oranges had significantly higher total phenolics, total anthocyanins and ascorbic acid levels than the corresponding non-organic oranges (all p < 0.05). Moreover, the organic orange extracts had a higher total antioxidant activity than non-organic orange extracts (p < 0.05). In addition, our results indicate that red oranges have a strong capacity of inhibiting the production of conjugated diene containing lipids and free radicals in rat cardiomyocytes and differentiated Caco-2 cells, respectively. Statistically higher levels of antioxidant activity in both cell models were found in organically grown oranges as compared to those produced by integrated agriculture practice. Our results clearly show that organic red oranges have a higher phytochemical content (i. e., phenolics, anthocyanins and ascorbic acid), total antioxidant activity and bioactivity than integrated red oranges. Further studies are needed to confirm whether the organic agriculture practice is likely to increase the antioxidant activity of

21 CFR 26.18 - Regulatory collaboration.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Regulatory collaboration. 26.18 Section 26.18 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL MUTUAL... Specific Sector Provisions for Pharmaceutical Good Manufacturing Practices § 26.18 Regulatory collaboration...

49 CFR 389.5 - Regulatory docket.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 5 2011-10-01 2011-10-01 false Regulatory docket. 389.5 Section 389.5...-FEDERAL MOTOR CARRIER SAFETY REGULATIONS General § 389.5 Regulatory docket. (a) Information and data... § 389.25; and final rules are maintained at headquarters, Federal Motor Carrier Safety Administration...

49 CFR 389.5 - Regulatory docket.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false Regulatory docket. 389.5 Section 389.5...-FEDERAL MOTOR CARRIER SAFETY REGULATIONS General § 389.5 Regulatory docket. (a) Information and data... § 389.25; and final rules are maintained at headquarters, Federal Motor Carrier Safety Administration...

Alcoholic fermentation induces melatonin synthesis in orange juice.

PubMed

Fernández-Pachón, M S; Medina, S; Herrero-Martín, G; Cerrillo, I; Berná, G; Escudero-López, B; Ferreres, F; Martín, F; García-Parrilla, M C; Gil-Izquierdo, A

2014-01-01

Melatonin (N-acetyl-5-methoxytryptamine) is a molecule implicated in multiple biological functions. Its level decreases with age, and the intake of foods rich in melatonin has been considered an exogenous source of this important agent. Orange is a natural source of melatonin. Melatonin synthesis occurs during alcoholic fermentation of grapes, malt and pomegranate. The amino acid tryptophan is the precursor of all 5-methoxytryptamines. Indeed, melatonin appears in a shorter time in wines when tryptophan is added before fermentation. The aim of the study was to measure melatonin content during alcoholic fermentation of orange juice and to evaluate the role of the precursor tryptophan. Identification and quantification of melatonin during the alcoholic fermentation of orange juice was carried out by UHPLC-QqQ-MS/MS. Melatonin significantly increased throughout fermentation from day 0 (3.15 ng/mL) until day 15 (21.80 ng/mL) reaching larger amounts with respect to other foods. Melatonin isomer was also analysed, but its content remained stable ranging from 11.59 to 14.18 ng/mL. The enhancement of melatonin occurred mainly in the soluble fraction. Tryptophan levels significantly dropped from 13.80 mg/L (day 0) up to 3.19 mg/L (day 15) during fermentation. Melatonin was inversely and significantly correlated with tryptophan (r = 0.907). Therefore, the enhancement in melatonin could be due to both the occurrence of tryptophan and the new synthesis by yeast. In summary, the enhancement of melatonin in novel fermented orange beverage would improve the health benefits of orange juice by increasing this bioactive compound. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Effects of photochemical smog on lemons and navel oranges

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, C.R.; Taylor, O.C.; Richards, B.L.

1970-05-01

Experiments were carried out on lemon and Navel orange trees to determine the kind and extent of damage caused by air pollution in the Los Angeles Basin. Trees were enclosed in filter-equipped greenhouses and compared with control trees which were exposed to ambient air. Yield of lemons was about one third more in filtered trees, and with oranges, the yield was about doubled. Fruit drop in oranges was a major problem associated with the exposure to ambient air pollution. Trees in ambient air were reduced in photosynthesis to 66% of filtered-air treatments. Fluoride, while present in the atmosphere was ofmore » minor importance to the health and performance of the trees. 2 tables.« less

National Wetland Mitigation Banking Study Wetland Migitation Banking.

DTIC Science & Technology

1994-02-01

the rest, but granted easements to HBWC 4. Mid City Ranch Humboldt CA Fish & Game CA Fish & Game, Humboldt CA Fish & Game County , CA City of...Eureka, Humboldt County County , City of Eureka 5. Mission Viejo/ Orange Mission Viejo USFWS, CA Dept. multiple - public- Orange ACWHEP...Broadway Wetlands Restoration Conceptual Plan yes in Humboldt County 6 - acre bank on 13-acre parcel mitigates for ’pockef marshes (2 acres

Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol.

PubMed

Lilja, Jari J; Juntti-Patinen, Laura; Neuvonen, Pertti J

2004-03-01

Grapefruit juice was recently found to decrease plasma concentrations of the beta-adrenergic receptor-blocking agent celiprolol. Our objective was to investigate the effect of orange juice on the pharmacokinetics of celiprolol in healthy subjects. In a randomized crossover study with 2 phases and a washout of 2 weeks, 10 healthy volunteers ingested either 200 mL normal-strength orange juice or water 3 times a day for 2 days. On the morning of day 3, 1 hour after ingestion of 200 mL orange juice or water, each subject ingested 100 mg celiprolol with either 200 mL orange juice or water. In addition, 200 mL orange juice or water was ingested at 4, 10, 22, and 27 hours after celiprolol intake. The concentrations of celiprolol in plasma and its excretion into urine were measured up to 33 hours after its dosing. Systolic and diastolic blood pressures and heart rate were recorded up to 10 hours. Orange juice reduced the mean peak plasma concentration of celiprolol by 89% (P <.01) and the mean area under the plasma celiprolol concentration-time curve by 83% (P <.01). The time to peak concentration of celiprolol increased from 4 to 6 hours (P <.05), and the half-life was prolonged from 4.6 to 10.8 hours (P =.05) after ingestion of orange juice. Orange juice reduced the urinary excretion of celiprolol by 77% (P <.01). No significant differences were observed in the hemodynamic variables between the phases. Orange juice substantially reduces the bioavailability of celiprolol, but the mechanism of this interaction remains to be resolved. For example, modulation of intestinal pH and of function of transporters implicated in the absorption of celiprolol may be involved. Because of the great extent of the orange juice-celiprolol interaction and a wide use of orange juice, this interaction is likely to have clinical importance in some patients, although hemodynamic consequences were not seen in young healthy subjects.

The Real Libraries of the OC

ERIC Educational Resources Information Center

Oder, Norman

2008-01-01

Sandwiched between Los Angeles and San Diego counties, nudging up to Riverside and San Bernardino to the east, Orange County, California is far more diverse than the stereotype. Orange County has no dominant city; its two largest, Santa Ana and Anaheim--each with populations around 350,000--are, respectively, home to lower-income Latinos and a…

77 FR 29750 - Notice of Intent To Prepare an Environmental Impact Statement: Milwaukee County

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-18

... Environmental Impact Statement: Milwaukee County AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of Intent. SUMMARY: The FHWA is issuing this notice to advise the public that an Environmental... Milwaukee County, Wisconsin. FOR FURTHER INFORMATION CONTACT: Bethaney Bacher-Gresock, Environmental Major...

Photoluminescence Properties of Ca3Si2O7: Pr3+ Orange-Red Phosphors Prepared by High-Temperature Solid-State Method

NASA Astrophysics Data System (ADS)

Peng, Zhi-Qing; Chen, Rong; Feng, Wen-Lin

2018-06-01

Novel luminescent materials Ca3-xSi2O7: xPr3+ were successfully prepared by the high-temperature solid-state method. The crystal structure, morphology, and optical spectrum were characterised by X-ray diffraction (XRD), scanning electron microscopy (SEM), and spectroscopy, respectively. The XRD patterns of the samples indicate that the crystal structure is monoclinic symmetry. The SEM shows that the selected sample has good crystallinity although its appearance is irregular and scalelike. The peak of the excitation spectrum of the sample is located at around 449 nm, corresponding to 3H4→3P2 transition of Pr3+. The peak of the emission spectrum of the sample is situated at around 612 nm which is attributed to 3P0→3H6 transition of Pr3+, and the colour is orange-red. The optimum concentration for Pr3+ replaced Ca2+ sites in Ca3Si2O7: Pr3+ is 0.75 mol%. The lifetime (8.48 μs) of a typical sample (Ca2.9925Pr0.0075)Si2O7 is obtained. It reveals that orange-red phosphors Ca3-xSi2O7: xPr3+ possess remarkable optical properties and can be used in white light emitting devices.

Los Angeles County Juvenile Justice Crime Prevention Act: Fiscal Year 2005-2006 Report

ERIC Educational Resources Information Center

Turner, Susan; Fain, Terry; Sehgal, Amber

2007-01-01

In 2000, the California State Legislature passed the Schiff-Cardenas Crime Prevention Act, which authorized funding for county juvenile justice programs and designated the Corrections Standards Authority (CSA), formerly named the Board of Corrections, the administrator of funding. California counties receiving state funds for Juvenile Justice…

Vietnamese Victims of Agent Orange and U.S.-Vietnam Relations

DTIC Science & Technology

2009-05-28

Hercules Inc., Monsanto Company, T-H Agricultural & Nutrition Company, Thompson Chemicals Corporation, and Uniroyal Inc. Agent Orange was one of 15...ban the import of agricultural and aquatic goods from Vietnam for health reasons. 85 Tom Fawthrop, “Agent Orange Victims Sue Monsanto ,” Corpwatch

Postharvest response of oranges of ethylene

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aharoni, Y.; Lattar, F.S.; Monselise, S.P.

1969-01-01

Since the effect of ethylene on the respiration rate of young unripe oranges has not yet been described, experiments were carried out to study the respiratory response of such fruits to ethylene. Oranges (Citrus sinensis (L.) Osbeck) of the Washington navel, Shamouti and Valencia varieties, growing on a sandy loam near Rehovot, Israel, were picked in June, July, September, December and January. Immediately after picking, they were weighed, placed in glass jars, and stored at 20/sup 0/. Each experiment comprised 12 jars, 4 for each variety. A constant stream (200 ml/min) of air containing 20 ppm of ethylene was runmore » through the jars. The respiration rate was measured by the amount of CO/sub 2/ evolved by the fruits, and based on a fresh weight unit. The results show that in all 3 varieties, ethylene caused an immediate rise in respiration rate, at all stages of development tested, regardless of whether it was applied from the beginning of the test or after a certain period of storage in air. The pattern of response to ethylene of young unripe oranges (picked in June, July, and September) was therefore similar to that of ripe ones (picked in December and January).« less

ORANGES evaluation discussion group process

DOT National Transportation Integrated Search

2003-03-24

This report describes and documents the process and methodology to be used to conduct a series of before and after discussion groups with smart card holders and participating agency employees as part of the ORANGES multiple purpose smart card Field O...

77 FR 30046 - Environmental Impact Statement: Wiscasset and Edgecomb, Lincoln County, ME

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-21

... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Environmental Impact Statement: Wiscasset and Edgecomb, Lincoln County, ME AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of Intent to Terminate (Withdraw) EIS. SUMMARY: The FHWA is issuing this notice to advise the...

75 FR 54220 - Environmental Impact Statement: Skowhegan and Madison, Somerset County, ME

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-03

... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Environmental Impact Statement: Skowhegan and Madison, Somerset County, ME AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of Intent to Terminate (Withdraw) EIS. SUMMARY: The FHWA is issuing this notice to advise the...

Real World Evidence for Regulatory Decisions: Concomitant Administration of Zoster Vaccine Live and Pneumococcal Polysaccharide Vaccine.

PubMed

Bruxvoort, Katia; Sy, Lina S; Luo, Yi; Tseng, Hung Fu

2018-04-11

The US Food and Drug Administration is charged with expanding the use of real world evidence (RWE) for regulatory decisions. As a test case for RWE to support regulatory decisions, we present the scenario of concomitant vaccination with zoster vaccine live (ZVL) and 23-valent pneumococcal polysaccharide vaccine (PPSV23). The prescribing information states that these vaccines should not be given concurrently, based on a small trial using varicella zoster virus antibody levels as a correlate of ZVL efficacy, even though ZVL protects against herpes zoster via cell-mediated immunity. We conducted an observational cohort study involving >30,000 members of Kaiser Permanente Southern California receiving concomitant ZVL and PPSV23 versus PPSV23 prior to ZVL. Occurrence of herpes zoster was assessed through electronic health records from January 1, 2007 to June 30, 2016. The adjusted hazard ratio comparing incidence rates of herpes zoster in the concomitant vaccination cohort and the prior vaccination cohort was 1.04 (95% CI: 0.92, 1.16). This RWE study provides direct evidence for a lack of vaccine interference, relying on herpes zoster occurrence rather than an intermediate marker of immunity. RWE is essential for regulators and policy makers in addressing evidentiary gaps regarding safety, effectiveness, compliance, and vaccine interactions for the new recombinant zoster vaccine.

Cold plasma treatment of valencia oranges reduces persistence of salmonella

USDA-ARS?s Scientific Manuscript database

Introduction: Fresh fruits such as oranges are an increasingly popular food, consumed directly or as ingredients in “raw” juice blends prepared at home or commercially at the point of consumption. However, because of past outbreaks associated with orange juice, and the risk of cross-contamination du...

Diversion of Airport Revenue Dade County Aviation Department

DOT National Transportation Integrated Search

1997-06-25

On February 13, 1996, the Federal Aviation Administration (FAA) Orlando : Airports District Office requested the Office of Inspector General to make an audit of airport revenue at the Dade County Aviation Department. The audit objective was to determ...

78 FR 26416 - Environmental Impact Statement: City of Buffalo, Erie County, New York

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-06

... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Environmental Impact Statement: City... statement will be prepared for a proposed highway project in the City of Buffalo, Erie County, New York. FOR... from the US Border Port of Entry/Peace Bridge Plaza (Plaza), in the City of Buffalo, Erie County, New...

Synthesis and Optical Spectroscopy of YPO4:Eu3+ Orange-Red Phosphors

NASA Astrophysics Data System (ADS)

Yahiaoui, Z.; Hassairi, M. A.; Dammak, M.

2017-08-01

YPO4: x mol.% Eu3+ phosphors with different dopant concentrations ( x = 3, 5, 8, 11, 13) have been synthesized via high-temperature solid-state reaction. X-ray diffraction analysis and Raman and infrared (IR) spectroscopy were applied for detailed structural characterization. Under excitation at wavelength of 395 nm, the photoluminescence spectra displayed the 5D0 → 7F J ( J = 1, 2, 3, 4) intra-4 f shell transitions related to Eu3+ ion. The radiative lifetime was estimated using the Ω 2 and Ω 4 Judd-Ofelt intensity parameters. The highest luminescence intensity was achieved for an optimal europium concentration of 11 mol.%. The critical energy-transfer distance for Eu3+ ions was evaluated to be 10.74 Å. We also studied the temperature-dependent photoluminescence and Commission Internationale de l'Éclairage chromaticity diagram. It was found that Eu3+-doped YPO4 exhibited good thermal stability and its emission intensity decreased slightly above room temperature. In addition, the color purity of this phosphor was as high as 91% for the YPO4:13% Eu3+ sample, making it a potential orange-red phosphor for application in ultraviolet-pumped white light-emitting diodes.

Gene coexpression network analysis of fruit transcriptomes uncovers a possible mechanistically distinct class of sugar/acid ratio-associated genes in sweet orange.

PubMed

Qiao, Liang; Cao, Minghao; Zheng, Jian; Zhao, Yihong; Zheng, Zhi-Liang

2017-10-30

The ratio of sugars to organic acids, two of the major metabolites in fleshy fruits, has been considered the most important contributor to fruit sweetness. Although accumulation of sugars and acids have been extensively studied, whether plants evolve a mechanism to maintain, sense or respond to the fruit sugar/acid ratio remains a mystery. In a prior study, we used an integrated systems biology tool to identify a group of 39 acid-associated genes from the fruit transcriptomes in four sweet orange varieties (Citrus sinensis L. Osbeck) with varying fruit acidity, Succari (acidless), Bingtang (low acid), and Newhall and Xinhui (normal acid). We reanalyzed the prior sweet orange fruit transcriptome data, leading to the identification of 72 genes highly correlated with the fruit sugar/acid ratio. The majority of these sugar/acid ratio-related genes are predicted to be involved in regulatory functions such as transport, signaling and transcription or encode enzymes involved in metabolism. Surprisingly, only three of these sugar/acid ratio-correlated genes are weakly correlated with sugar level and none of them overlaps with the acid-associated genes. Weighted Gene Coexpression Network Analysis (WGCNA) has revealed that these genes belong to four modules, Blue, Grey, Brown and Turquoise, with the former two modules being unique to the sugar/acid ratio control. Our results indicate that orange fruits contain a possible mechanistically distinct class of genes that may potentially be involved in maintaining fruit sugar/acid ratios and/or responding to the cellular sugar/acid ratio status. Therefore, our analysis of orange transcriptomes provides an intriguing insight into the potentially novel genetic or molecular mechanisms controlling the sugar/acid ratio in fruits.

Credit BG. Northwest and southwest facades of Administration Building for ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit BG. Northwest and southwest facades of Administration Building for Building 4505 area. Construction began on this building in 1967 - Edwards Air Force Base, North Base, Administration Building, Northeast of A Street, Boron, Kern County, CA

Rare earth element transfer from soil to navel orange pulp (Citrus sinensis Osbeck cv. Newhall) and the effects on internal fruit quality.

PubMed

Cheng, Jinjin; Ding, Changfeng; Li, Xiaogang; Zhang, Taolin; Wang, Xingxiang

2015-01-01

The effects of soil rare earth element (REE) on navel orange quality and safety in rare earth ore areas have gained great attention. This study investigated the transfer characteristics of REE from soil to navel orange pulp (Citrus sinensis Osbeck cv. Newhall) and examined the effects of soil REE on internal fruit quality in Xinfeng County, Jiangxi province, China. Path analysis showed that soil REE, pH, cation exchange capacity (CEC), and Fe oxide (Feox) significantly affected pulp REE concentrations. A Freundlich-type prediction model for pulp REE was established: log[REEpulp] = -1.036 + 0.272 log[REEsoil] - 0.056 pH - 0.360 log[CEC] + 0.370 log[Feox] (n = 114, R2 = 0.60). From the prediction model, it was inferred that even when soil REE and Feox were as high as 1038 mg kg-1 and 96.4 g kg-1, respectively, and pH and CEC were as low as 3.75 and 5.08 cmol kg-1, respectively, pulp REE concentrations were much lower than the food limit standard. Additionally, soil REE levels were significantly correlated with selected fruit quality indicators, including titratable acidity (r = 0.52, P < 0.01), total soluble solids (r = 0.48, P < 0.01) and vitamin C (r = 0.56, P < 0.01). Generally, under routine methods of water and fertilization management, the cultivation of navel oranges in rare earth ore areas of south China with soil REE ranging from 38.6 to 546 mg kg-1 had improved in internal fruit quality.

Rare Earth Element Transfer from Soil to Navel Orange Pulp (Citrus sinensis Osbeck cv. Newhall) and the Effects on Internal Fruit Quality

PubMed Central

Cheng, Jinjin; Ding, Changfeng; Li, Xiaogang; Zhang, Taolin; Wang, Xingxiang

2015-01-01

The effects of soil rare earth element (REE) on navel orange quality and safety in rare earth ore areas have gained great attention. This study investigated the transfer characteristics of REE from soil to navel orange pulp (Citrus sinensis Osbeck cv. Newhall) and examined the effects of soil REE on internal fruit quality in Xinfeng County, Jiangxi province, China. Path analysis showed that soil REE, pH, cation exchange capacity (CEC), and Fe oxide (Feox) significantly affected pulp REE concentrations. A Freundlich-type prediction model for pulp REE was established: log[REEpulp] = -1.036 + 0.272 log[REEsoil] - 0.056 pH - 0.360 log[CEC] + 0.370 log[Feox] (n = 114, R2 = 0.60). From the prediction model, it was inferred that even when soil REE and Feox were as high as 1038 mg kg-1 and 96.4 g kg-1, respectively, and pH and CEC were as low as 3.75 and 5.08 cmol kg-1, respectively, pulp REE concentrations were much lower than the food limit standard. Additionally, soil REE levels were significantly correlated with selected fruit quality indicators, including titratable acidity (r = 0.52, P < 0.01), total soluble solids (r = 0.48, P < 0.01) and vitamin C (r = 0.56, P < 0.01). Generally, under routine methods of water and fertilization management, the cultivation of navel oranges in rare earth ore areas of south China with soil REE ranging from 38.6 to 546 mg kg-1 had improved in internal fruit quality. PMID:25806821

Educating the Orang Asli Children: Exploring Indigenous Children's Practices and Experiences in Schools

ERIC Educational Resources Information Center

Renganathan, Sumathi

2016-01-01

The author is concerned with the education available for the Orang Asli, an indigenous minority community in Malaysia. Literature written about Orang Asli and education mostly assumes a deficit perspective where the lack of educational achievement among the Orang Asli children is often attributed to their culture and community. Therefore, rather…

75 FR 55968 - Special Local Regulations, Sabine River; Orange, TX

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-15

...-AA08 Special Local Regulations, Sabine River; Orange, TX AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary Special Local Regulation in the Port Arthur Captain of the Port Zone on the Sabine River, Orange, Texas. This Special Local Regulation is...

10 CFR 580.04 - Administrative procedures. [Reserved

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Administrative procedures. [Reserved] 580.04 Section 580.04 Energy DEPARTMENT OF ENERGY (CONTINUED) NATURAL GAS (ECONOMIC REGULATORY ADMINISTRATION) CURTAILMENT PRIORITIES FOR ESSENTIAL AGRICULTURAL USES § 580.04 Administrative procedures. [Reserved] ...

Environmental analysis of geopressured-geothermal prospect areas, Brazoria and Kenedy Counties, Texas

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, W.A.; McGraw, M.; Gustavson, T.C.

Preliminary environmental data, including current land use, substrate lithology, soils, natural hazards, water resources, biological assemblages, meteorological data, and regulatory considerations have been collected and analyzed for approximately 150 km/sup 2/ of land: (1) near Chocolate Bayou, Brazoria County, Texas, where a geopressured-geothermal test well was drilled in 1978, and (2) near the rural community of Armstrong, Kenedy County, Texas, where future geopressured-geothermal test well development may occur. The study was designed to establish an environmental data base and to determine, within spatial constraints set by subsurface reservoir conditions, environmentally suitable sites for geopressured-geothermal wells.

76 FR 8726 - Western Area Power Administration; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-15

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EF11-4-000] Western Area Power Administration; Notice of Filing Take notice that on February 3, 2011, the Western Area Power Administration, pursuant to Order No. 714,\\1\\ and the Federal Energy Regulatory Commission's (Commission) Order...

Aroma Leakage from Orange Juice Packed in Gable-Top Paper Containers for Chilled Distribution.

PubMed

Aoki, Risa; Tokuda, Aika; Shigemura, Yasutaka; Mineki, Machiko; Sato, Yoshio

2017-01-01

We conducted a study to examine aroma leakage from orange juice packed in gable-top paper containers for chilled distribution. Limonene, an aromatic component of orange juice, was considered as an index compound of aroma leakage, and its seepage on the surface of the container and concentration in the orange juice were measured by GC-MS for 12 commercial samples. After 3 days of storage, limonene was detected on the surface of 8 orange juice containers, and the concentration of limonene in the orange juice was found to have decreased. Thus, limonene leaked through the container within a few days, and the extent of leakage differed between containers, presumably depending upon their barrier properties. In addition, limonene was detected in green tea and milk that was stored together with the unopened orange juice containers at 4℃. The transference of orange aroma into milk was significant, because the contamination of the milk was confirmed by subjective sensory evaluation. This study suggests the possibility of transfer of aroma compounds through paper containers to other beverages.

Variability of Carotenoid Biosynthesis in Orange Colored Capsicum spp.

PubMed Central

Guzman, Ivette; Hamby, Shane; Romero, Joslynn; Bosland, Paul W.; O’Connell, Mary A.

2010-01-01

Pepper, Capsicum spp., is a worldwide crop valued for heat, nutrition, and rich pigment content. Carotenoids, the largest group of plant pigments, function as antioxidants and as vitamin A precursors. The most abundant carotenoids in ripe pepper fruits are β-carotene, capsanthin, and capsorubin. In this study, the carotenoid composition of orange fruited Capsicum lines was defined along with the allelic variability of the biosynthetic enzymes. The carotenoid chemical profiles present in seven orange pepper varieties were determined using a novel UPLC method. The orange appearance of the fruit was due either to the accumulation of β-carotene, or in two cases, due to only the accumulation of red and yellow carotenoids. Four carotenoid biosynthetic genes, Psy, Lcyb, CrtZ-2, and Ccs were cloned and sequenced from these cultivars. This data tested the hypothesis that different alleles for specific carotenoid biosynthetic enzymes are associated with specific carotenoid profiles in orange peppers. While the coding regions within Psy and CrtZ-2 did not change in any of the lines, the genomic sequence contained introns not previously reported. Lcyb and Ccs contained no introns but did exhibit polymorphisms resulting in amino acid changes; a new Ccs variant was found. When selectively breeding for high provitamin A levels, phenotypic recurrent selection based on fruit color is not sufficient, carotenoid chemical composition should also be conducted. Based on these results, specific alleles are candidate molecular markers for selection of orange pepper lines with high β-carotene and therefore high pro-vitamin A levels. PMID:20582146

Citrus sinensis annotation project (CAP): a comprehensive database for sweet orange genome.

PubMed

Wang, Jia; Chen, Dijun; Lei, Yang; Chang, Ji-Wei; Hao, Bao-Hai; Xing, Feng; Li, Sen; Xu, Qiang; Deng, Xiu-Xin; Chen, Ling-Ling

2014-01-01

Citrus is one of the most important and widely grown fruit crop with global production ranking firstly among all the fruit crops in the world. Sweet orange accounts for more than half of the Citrus production both in fresh fruit and processed juice. We have sequenced the draft genome of a double-haploid sweet orange (C. sinensis cv. Valencia), and constructed the Citrus sinensis annotation project (CAP) to store and visualize the sequenced genomic and transcriptome data. CAP provides GBrowse-based organization of sweet orange genomic data, which integrates ab initio gene prediction, EST, RNA-seq and RNA-paired end tag (RNA-PET) evidence-based gene annotation. Furthermore, we provide a user-friendly web interface to show the predicted protein-protein interactions (PPIs) and metabolic pathways in sweet orange. CAP provides comprehensive information beneficial to the researchers of sweet orange and other woody plants, which is freely available at http://citrus.hzau.edu.cn/.

Purple is the new Orange

USDA-ARS?s Scientific Manuscript database

Blood orange and Cara cara-like citrus varieties with purple or red fruit color, increased antioxidants and modified flavor could be the next generation of cultivars produced via genetic engineering. These varieties are being developed by enhancing the presence of anthocyanin and lycopene pigments...

The CaO orange system in meteor spectra

NASA Astrophysics Data System (ADS)

Berezhnoy, A. A.; Borovička, J.; Santos, J.; Rivas-Silva, J. F.; Sandoval, L.; Stolyarov, A. V.; Palma, A.

2018-02-01

The CaO orange band system was simulated in the region 5900-6300 Å and compared with the experimentally observed spectra of Benešov bolide wake. The required vibronic Einstein emission coefficients were estimated by means of the experimental radiative lifetimes under the simplest Franck-Condon approximation. A moderate agreement was achieved, and the largest uncertainties come from modeling shape of FeO orange bands. Using a simple model the CaO column density in the wake of the Benešov bolide at the height of 29 km was estimated as (5 ± 2) × 1014 cm-2 by a comparison of the present CaO spectra with the AlO bands nicely observed at 4600-5200 Å in the same spectrum. The obtained CaO content is in a good agreement with the quenching model developed for the impact-produced cloud, although future theoretical and experimental studies of both CaO and FeO orange systems contribution would be needed to confirm these results.

76 FR 411 - Regulatory Guidance Concerning Electronic Signatures and Documents

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-04

... Concerning Electronic Signatures and Documents AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of regulatory guidance. SUMMARY: FMCSA issues regulatory guidance concerning the... regulatory guidance concerning the use of electronic signatures and documents to comply with FMCSA...

Absence of furanocoumarins in Advantra Z® (Citrus aurantium, bitter orange) extracts.

PubMed

Stohs, Sidney J; Miller, Howard; Romano, Felice

2014-09-01

Grapefruit (Citrus paradisi) juice is known for its ability to alter drug metabolism through inhibition of the cytochrome P450-3A4 (CYP3A4) system, and result in drug-food interactions that may be life threatening. The primary active ingredients in grapefruit responsible for these effects are the furanocoumarins bergapten, bergamottin, and 6',7'-dihydroxybergamottin (DHB). Bergamottin and DHB appear to be the most important in terms of adverse drug interactions. Furanocoumarins are present in the juices and fruits of other Citrus species including C. aurantium (bitter oranges). Bergapten is the predominant furanocoumarin in bitter orange. Bitter orange extracts are widely used in products associated with weight loss, sports performance, and energy production. Questions have been raised about the potential of bitter orange extracts to cause drug interactions. This study examined the furanocoumarin content of four standardized bitter orange extracts (Advantra Z®) by liquid chromatography-mass spectroscopy. The results indicated that the total furanocoumarin content of each of the four extracts was less than 20 μg/g, amounts insufficient to exert significant effects on the metabolism of susceptible drugs in human subjects at the doses commonly used for these extracts.

A reconnaissance of hydrogeologic conditions in Lehigh Acres and adjacent areas of Lee County, Florida

USGS Publications Warehouse

Boggess, Durward Hoye; Missimer, T.M.

1975-01-01

Lehigh Acres, a residential community with a population of about 13,500 and comprising an area of about 94 square miles (243 square kilometres) in the eastern part of Lee County, has been under development since 1954. Prior to development the area was poorly drained. By 1974, more than 150 miles (241 kilometres) of drainageways had been constructed to drain the area. The water-bearing formations underlying Lehigh Acres include the water-table, sandstone, lower Hawthorn, and Suwannee aquifers. The water-table aquifer is usually not more than 30 feet (9 metres) thick; it contains water of relatively good quality, except for iron and color. Water levels in this aquifer probably have been affected by construction of drainage canals. The sandstone aquifer, used extensively throughout the area as a source of water supply usually contains water of good quality although the water is hard and in places may contain concentrations of dissolved solids and iron which exceed the recommended limits of the U.S. Public Health Service and the State of Florida for drinking water. The lower Hawthorn and Suwannee aquifers, usually encountered at depths between 440 and 850 feet (135 and 262 metres), contains water with relatively high concentrations of sodium, sulfate, chloride, and dissolved solids. Three streams, the Orange River, Hickey Creek, and Bedman Creek and the canals connected to them, provide drainage of the area. Except for the Orange River, where the water is of good chemical quality, little is known of the water quality. Similarly, little information is available on stream discharge except for the Orange River where the average annual discharge was 41.1 cubic feet per second (11.6 cubic metres per second) between 1935-46. Most lakes and ponds in Lehigh Acres are hydraulically connected to the water-table aquifer such that factors which affect one also affect the other. Theoretical drawdown curves indicate that the drainage canals may affect ground-water levels to a

Tracking the degradation of fresh orange juice and discrimination of orange varieties: an example of NMR in coordination with chemometrics analyses.

PubMed

de Oliveira, Clayton R; Carneiro, Renato L; Ferreira, Antonio G

2014-12-01

Brazil is currently the largest exporter of concentrated orange juice and, unlike the other exporter countries, the domestic consumption is mainly based on the fresh orange juice. The quality control by evaluating the major chemical constituents under the influence of the most important factors, such as temperature and storage time of the product, is very important in this context. Therefore, the objective of this study was to evaluate the influence of temperature and time on the degradation of fresh orange juice for 24h, by using (1)H NMR technique and chemometric tools for data mining. The storage conditions at 24h led to the production of the formic, fumaric and acetic acids; and an increase of succinic and lactic acids and ethanol, which were observed at low concentration at the initial time. Furthermore, analysis by PCA has successfully distinguished the juice of different species/varieties as well as the metabolites responsible for their separation. Copyright © 2014 Elsevier Ltd. All rights reserved.

A review of Agent Orange and its associated oncologic risk of genitourinary cancers.

PubMed

Chang, Chrystal; Benson, Michael; Fam, Mina M

2017-11-01

Agent Orange is an herbicide sprayed widely in Vietnam that is linked to a variety of malignancies in as early as 1991.Since then, there has been concern for, and subsequent interest in studying, the potential connection between Agent Orange and other malignancies. In the past 2 decades, there have been significant changes in the opinion of the National Academy of Science regarding Agent Orange and certain genitourinary malignancies. Herein, we review the literature regarding the potential link between Agent Orange and various urological cancers, including prostate, bladder, testicular, and renal cancers. Copyright © 2017 Elsevier Inc. All rights reserved.

1. View looking southwest showing from left to right: Administration/Terminal ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. View looking southwest showing from left to right: Administration/Terminal Building and brick hangar. - Manchester Airport, Administration-Terminal Building, East of Pine Island Pond, south of North Perimeter Road, Manchester, Hillsborough County, NH

5 CFR 1315.19 - Regulatory references to OMB Circular A-125.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Regulatory references to OMB Circular A-125. 1315.19 Section 1315.19 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES PROMPT PAYMENT § 1315.19 Regulatory references to OMB Circular A-125. This part supercedes OMB Circular A...

28 CFR 55.9 - Coverage of political units within a county.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Coverage of political units within a county. 55.9 Section 55.9 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) IMPLEMENTATION OF THE PROVISIONS OF THE VOTING RIGHTS ACT REGARDING LANGUAGE MINORITY GROUPS Nature of Coverage § 55.9 Coverage of...

28 CFR 55.9 - Coverage of political units within a county.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Coverage of political units within a county. 55.9 Section 55.9 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) IMPLEMENTATION OF THE PROVISIONS OF THE VOTING RIGHTS ACT REGARDING LANGUAGE MINORITY GROUPS Nature of Coverage § 55.9 Coverage of...

Garen Goebel, Washington County, KS - Public Notice Document

EPA Pesticide Factsheets

Environmental Protection Agency (“EPA”) is providing notice of a proposed Administrative Penalty Assessment against Garen Goebel for alleged violations of Section 301of the Clean Water Act, 33 U.S.C. § 1311 at a site located in Washington County, Kansas.

Metabolic engineering of β-carotene in orange fruit increases its in vivo antioxidant properties.

PubMed

Pons, Elsa; Alquézar, Berta; Rodríguez, Ana; Martorell, Patricia; Genovés, Salvador; Ramón, Daniel; Rodrigo, María Jesús; Zacarías, Lorenzo; Peña, Leandro

2014-01-01

Orange is a major crop and an important source of health-promoting bioactive compounds. Increasing the levels of specific antioxidants in orange fruit through metabolic engineering could strengthen the fruit's health benefits. In this work, we have afforded enhancing the β-carotene content of orange fruit through blocking by RNA interference the expression of an endogenous β-carotene hydroxylase gene (Csβ-CHX) that is involved in the conversion of β-carotene into xanthophylls. Additionally, we have simultaneously overexpressed a key regulator gene of flowering transition, the FLOWERING LOCUS T from sweet orange (CsFT), in the transgenic juvenile plants, which allowed us to obtain fruit in an extremely short period of time. Silencing the Csβ-CHX gene resulted in oranges with a deep yellow ('golden') phenotype and significant increases (up to 36-fold) in β-carotene content in the pulp. The capacity of β-carotene-enriched oranges for protection against oxidative stress in vivo was assessed using Caenorhabditis elegans as experimental animal model. Golden oranges induced a 20% higher antioxidant effect than the isogenic control. This is the first example of the successful metabolic engineering of the β-carotene content (or the content of any other phytonutrient) in oranges and demonstrates the potential of genetic engineering for the nutritional enhancement of fruit tree crops. © 2013 Society for Experimental Biology, Association of Applied Biologists and John Wiley & Sons Ltd.

21 CFR 146.148 - Reduced acid frozen concentrated orange juice.

Code of Federal Regulations, 2014 CFR

2014-04-01

... that the ratio of the Brix reading to the grams of acid, expressed as anhydrous citric acid, per 100... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Reduced acid frozen concentrated orange juice. 146... Canned Fruit Juices and Beverages § 146.148 Reduced acid frozen concentrated orange juice. (a) Reduced...

21 CFR 146.148 - Reduced acid frozen concentrated orange juice.

Code of Federal Regulations, 2012 CFR

2012-04-01

... that the ratio of the Brix reading to the grams of acid, expressed as anhydrous citric acid, per 100... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Reduced acid frozen concentrated orange juice. 146... Canned Fruit Juices and Beverages § 146.148 Reduced acid frozen concentrated orange juice. (a) Reduced...

21 CFR 146.148 - Reduced acid frozen concentrated orange juice.

Code of Federal Regulations, 2011 CFR

2011-04-01

... that the ratio of the Brix reading to the grams of acid, expressed as anhydrous citric acid, per 100... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Reduced acid frozen concentrated orange juice. 146... Canned Fruit Juices and Beverages § 146.148 Reduced acid frozen concentrated orange juice. (a) Reduced...

21 CFR 146.148 - Reduced acid frozen concentrated orange juice.

Code of Federal Regulations, 2013 CFR

2013-04-01

... that the ratio of the Brix reading to the grams of acid, expressed as anhydrous citric acid, per 100... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Reduced acid frozen concentrated orange juice. 146... Canned Fruit Juices and Beverages § 146.148 Reduced acid frozen concentrated orange juice. (a) Reduced...

Navel orange peel hydroethanolic extract, naringin and naringenin have anti-diabetic potentials in type 2 diabetic rats.

PubMed

Ahmed, Osama M; Hassan, Mohamed A; Abdel-Twab, Sanaa M; Abdel Azeem, Manal N

2017-10-01

The therapy of Type 2 Diabetes Mellitus (T2DM) stays a challenging issue. During the last decade, there has been an interest in the expansion of anti-diabetic drugs especially those of natural sources. Thus, the aim of this study was to assess the anti-hyperglycemic and the anti-hyperlipidemic effects as well as the anti-oxidant activities of navel orange hydroethanolic extract and its constituting flavonoids naringin and naringenin on nicotineamide (NA)/streptozotocin (STZ)-induced type 2 diabetic rats. To induce T2DM, 16h-fasted rats were intraperitoneally injected with STZ at dose of 50mg/kg body weight (b. w.), 15min after the intraperitoneal administration of NA (120mg/kg b. w.). The NA/STZ-induced type 2 diabetic rats were orally treated with navel orange peel hydroethanolic extract, naringin and narengenin at dose level of 100mg/kg b. w./day for 4 weeks. The treatments with navel orange peel hydroethanolic extract, naringin and narengenin potentially alleviated the lowered serum insulin and C-peptide levels, the depleted liver glycogen content, the elevated liver glucose-6-phosphatase and glycogen phosphorylase activities, the deteriorated serum lipid profile, and the suppressed liver antioxidant defense system of NA/STZ-induced type 2 diabetic rats. The treatments also enhanced the mRNA expression of insulin receptor β-subunit, GLUT4 and adiponectin in adipose tissue of STZ/NA-induced type 2 diabetic rats. In conclusion, the navel orange peel hydroethanolic extract, naringin and naringenin have potent anti-diabetic effects in NA/STZ-induced type 2 diabetic rats via their insulinotropic effects and insulin improving action which in turn may be mediated through enhancing insulin receptor, GLUT4 and adiponectin expression in adipose tissue. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

View from southeast to northwest of administration building. Community center ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View from southeast to northwest of administration building. Community center can be seen in far left background - Stanley R. Mickelsen Safeguard Complex, Administrative Headquarters Building, In Controlled Area just off Avenue A & East of Pump House, Nekoma, Cavalier County, ND

76 FR 4919 - Regulatory Site Visit Training Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-27

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2011-N-0046] Regulatory Site Visit Training Program AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration's (FDA's) Center for Biologics Evaluation and Research (CBER) is...

75 FR 6404 - Regulatory Site Visit Training Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-09

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2008-N-0045] (formerly Docket No. 2004N-0408) Regulatory Site Visit Training Program AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration's (FDA's) Center for Biologics...

75 FR 77938 - Notice of Intent To Release Certain Properties From Federal Obligations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-14

... the property for other than aeronautical purposes. The property is located adjacent to Crystal Lake Drive in Orange County, Florida. The parcel is currently designated as non-aeronautical use. The....71 acre parcels to be acquired is also located adjacent to Crystal Lake Drive in Orange County...

Low temperature solution process-based defect-induced orange-red light emitting diode

PubMed Central

Biswas, Pranab; Baek, Sung-Doo; Hoon Lee, Sang; Park, Ji-Hyeon; Jeong Lee, Su; Il Lee, Tae; Myoung, Jae-Min

2015-01-01

We report low-temperature solution-processed p-CuO nanorods (NRs)/n-ZnO NRs heterojunction light emitting diode (LED), exploiting the native point defects of ZnO NRs. ZnO NRs were synthesized at 90 °C by using hydrothermal method while CuO NRs were synthesized at 100 °C by using microwave reaction system. The electrical properties of newly synthesized CuO NRs revealed a promising p-type nature with a hole concentration of 9.64 × 1018 cm−3. The current-voltage characteristic of the heterojunction showed a significantly high rectification ratio of 105 at 4 V with a stable current flow. A broad orange-red emission was obtained from the forward biased LED with a major peak at 610 nm which was attributed to the electron transition from interstitial zinc to interstitial oxygen point defects in ZnO. A minor shoulder peak was also observed at 710 nm, corresponding to red emission which was ascribed to the transition from conduction band of ZnO to oxygen vacancies in ZnO lattice. This study demonstrates a significant progress toward oxide materials based, defect-induced light emitting device with low-cost, low-temperature methods. PMID:26648420

Characterization and luminescence properties of Sr3Gd): Sm3+ orange-red phosphor

NASA Astrophysics Data System (ADS)

Yang, Zaifa; Xu, Denghui; Sun, Jiayue; Sun, Yumei; Du, Haiyan

2015-10-01

Reddish-orange emitting phosphors, Sr3Gd): Sm3+, were successfully synthesized by a conventional solid-state reaction. The crystal structure of the phosphors was characterized by x-ray diffraction. The excitation spectra and emission spectra were utilized to characterize the luminescence properties of the as-prepared phosphors. The results show that the phosphor consisted of some sharp emission peaks of Sm3+ ions centered at 564, 600, 647, and 707 nm, respectively. The critical distance of Sr3Gd0.93): 0.07Sm3+ was calculated to be 19.18 Å and the lifetime value of the sample was 1.63 ms. The band gap of Sr3Gd) was estimated to be about 2.74 eV from the diffuse reflection spectrum. The optimum doping concentration is 7 mol. % and the quenching occurs via dipole-dipole interaction according to Dexter's theory. The Commission Internationale de L'Eclairage value of Sr3Gd): Sm3+ phosphors presented that it has high color purity. These results indicated that the Sr3Gd): Sm3+ may be a promising reddish-orange emitting phosphor for cost-effective near ultraviolet white light-emitting diodes.

Lunar volcanism - Age of the glass in the Apollo 17 orange soil.

NASA Technical Reports Server (NTRS)

Husain, L.; Schaeffer, O. A.

1973-01-01

Glasses on the moon can form either by impact or by volcanic processes. An age determination indicates that the glass of the orange soil formed close in time to the volcanic activity in the Sea of Serenity about 3,750 million years ago. The orange soil was certainly not formed by a recent fumarole. The young exposure age, about 32 million years, found for the glass of the orange soil is in agreement with its fresh appearance on the lunar surface.

Interleukin-35 administration counteracts established murine type 1 diabetes--possible involvement of regulatory T cells.

PubMed

Singh, Kailash; Kadesjö, Erik; Lindroos, Julia; Hjort, Marcus; Lundberg, Marcus; Espes, Daniel; Carlsson, Per-Ola; Sandler, Stellan; Thorvaldson, Lina

2015-07-30

The anti-inflammatory cytokine IL-35 is produced by regulatory T (Treg) cells to suppress autoimmune and inflammatory responses. The role of IL-35 in type 1 diabetes (T1D) remains to be answered. To elucidate this, we investigated the kinetics of Treg cell response in the multiple low dose streptozotocin induced (MLDSTZ) T1D model and measured the levels of IL-35 in human T1D patients. We found that Treg cells were increased in MLDSTZ mice. However, the Treg cells showed a decreased production of anti-inflammatory (IL-10, IL-35, TGF-β) and increased pro-inflammatory (IFN-γ, IL-2, IL-17) cytokines, indicating a phenotypic shift of Treg cells under T1D condition. IL-35 administration effectively both prevented development of, and counteracted established MLDSTZ T1D, seemingly by induction of Eos expression and IL-35 production in Treg cells, thus reversing the phenotypic shift of the Treg cells. IL-35 administration reversed established hyperglycemia in NOD mouse model of T1D. Moreover, circulating IL-35 levels were decreased in human T1D patients compared to healthy controls. These findings suggest that insufficient IL-35 levels play a pivotal role in the development of T1D and that treatment with IL-35 should be investigated in treatment of T1D and other autoimmune diseases.

Effect of orange rust on sugarcane breeding program at canal Point

USDA-ARS?s Scientific Manuscript database

Orange rust of sugarcane (Saccharum spp. hybrids), caused by Puccinia kuehnii (W. Krüger) E.J. Butler, appeared in the Western Hemisphere ten years ago. Orange rust substantially reduces yields in susceptible sugarcane genotypes. Majority of the commercial cultivars were susceptible at the time of o...

76 FR 71108 - Applications of Orange Air, LLC for Certificate Authority

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-16

... DEPARTMENT OF TRANSPORTATION Office of the Secretary Applications of Orange Air, LLC for Certificate Authority AGENCY: Department of Transportation. ACTION: Notice of Order to Show Cause (Order 2011... directing all interested persons to show cause why it should not issue orders finding Orange Air, LLC, fit...

Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins.

PubMed

Malhotra, S; Bailey, D G; Paine, M F; Watkins, P B

2001-01-01

Our objective was to determine whether Seville orange juice produces a grapefruit juice-like interaction with felodipine and whether bergamottin, 6',7'-dihydroxybergamottin, or other furocoumarins are involved. In a randomized three-way crossover design, 10 volunteers received a felodipine 10-mg extended-release tablet with 240 mL of Seville orange juice, dilute grapefruit juice (that contained equivalent total molar concentrations of bergamottin plus 6',7'-dihydroxybergamottin), or common orange juice (negative control). The pharmacokinetics of felodipine and its dehydrofelodipine metabolite were determined. Juice concentrations of furocoumarins were measured. CYP3A4 inhibitory activity of newly identified furocoumarins was assessed. The felodipine area under the plasma concentration-time curve was increased by 76% and 93% after Seville orange juice and grapefruit juice ingestion, respectively, compared with common orange juice. The effects of Seville orange juice and grapefruit juice were similar in that the felodipine maximum concentration was augmented while the terminal elimination half-life was unchanged and the dehydrofelodipine area under the plasma concentration time-curve was increased, but the dehydrofelodipine-felodipine area under the plasma concentration-time curve ratio was reduced. Bergamottin and 6',7'-dihydroxybergamottin concentrations were 5 and 36 micromol/L, respectively, in Seville orange juice and were 16 and 23 micromol/L, respectively, in dilute grapefruit juice. A newly identified furocoumarin, bergapten, was detected only in Seville orange juice (31 micromol/L), and it was found to be a mechanism-based inhibitor of recombinant CYP3A4. Relative to the control, 6',7'-dihydroxybergamottin (10 micromol/L) inhibited CYP3A4 activity in cultured intestinal epithelial cells by 93%, whereas bergapten (10 micromol/L) inhibited the activity by only 34%. Seville orange juice and grapefruit juice interact with felodipine by a common mechanism, which

Federal Highway Administration finding of no significant impact for the Iowa Highway 86 (IA 86) from IA 9 to 700 feet south of 110th Street Dickinson County STP-086-1(10)--2C-30.

DOT National Transportation Integrated Search

2011-08-08

The Iowa Department of Transportation (Iowa DOT) and the Federal Highway Administration (FHWA) propose to improve a 3.9-mile segment of Iowa Highway 86 (IA 86) from Iowa Highway 9 (IA 9) to near the Minnesota border within Dickinson County, Iowa (the...

Federal Highway Administration finding of no significant impact for the Iowa highway 86 (IA 86) from IA 9 to 700 feet south of 110th street Dickinson County STP-086-1(10)--2C-30.

DOT National Transportation Integrated Search

2011-09-08

The Iowa Department of Transportation (Iowa DOT) and the Federal Highway Administration (FHWA) propose to improve a 3.9-mile segment of Iowa Highway 86 (IA 86) from Iowa Highway 9 (IA 9) to near the Minnesota border within Dickinson County, Iowa (the...

Geophysical investigation of sentinel lakes in Lake, Seminole, Orange, and Volusia Counties, Florida

USGS Publications Warehouse

Reich, Christopher; Flocks, James; Davis, Jeffrey

2012-01-01

This study was initiated in cooperation with the St. Johns River Water Management District (SJRWMD) to investigate groundwater and surface-water interaction in designated sentinel lakes in central Florida. Sentinel lakes are a SJRWMD established set of priority water bodies (lakes) for which minimum flows and levels (MFLs) are determined. Understanding both the structure and lithology beneath these lakes can ultimately lead to a better understanding of the MFLs and why water levels fluctuate in certain lakes more so than in other lakes. These sentinel lakes have become important water bodies to use as water-fluctuation indicators in the SJRWMD Minimum Flows and Levels program and will be used to define long-term hydrologic and ecologic performance measures. Geologic control on lake hydrology remains poorly understood in this study area. Therefore, the U.S. Geological Survey investigated 16 of the 21 water bodies on the SJRWMD priority list. Geologic information was obtained by the tandem use of high-resolution seismic profiling (HRSP) and direct-current (DC) resistivity profiling to isolate both the geologic framework (structure) and composition (lithology). Previous HRSP surveys from various lakes in the study area have been successful in identifying karst features, such as subsidence sinkholes. However, by using this method only, it is difficult to image highly irregular or chaotic surfaces, such as collapse sinkholes. Resistivity profiling was used to complement HRSP by detecting porosity change within fractured or collapsed structures and increase the ability to fully characterize the subsurface. Lake Saunders (Lake County) is an example of a lake composed of a series of north-south-trending sinkholes that have joined to form one lake body. HRSP shows surface depressions and deformation in the substrate. Resistivity data likewise show areas in the southern part of the lake where resistivity shifts abruptly from approximately 400 ohm meters (ohm-m) along the

78 FR 21703 - Environmental Impact Statement: Cherokee and Forsyth Counties, Georgia

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-11

... transportation project (State Route 20) located in Cherokee and Forsyth Counties, Georgia. FOR FURTHER... this program.) Issued on: April 5, 2013. Rodney N. Barry, Division Administrator, Atlanta, Georgia. [FR...

18 CFR 401.33 - Administrative agreements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... agreements. 401.33 Section 401.33 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION... Administrative agreements. The Executive Director is authorized and directed to enter into cooperative Administrative Agreements with federal and state regulatory agencies concerned with the review of projects under...

18 CFR 401.33 - Administrative agreements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... agreements. 401.33 Section 401.33 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION... Administrative agreements. The Executive Director is authorized and directed to enter into cooperative Administrative Agreements with federal and state regulatory agencies concerned with the review of projects under...

18 CFR 401.33 - Administrative agreements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... agreements. 401.33 Section 401.33 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION... Administrative agreements. The Executive Director is authorized and directed to enter into cooperative Administrative Agreements with federal and state regulatory agencies concerned with the review of projects under...

49 CFR 372.225 - Lexington-Fayette Urban County, KY.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false Lexington-Fayette Urban County, KY. 372.225 Section 372.225 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS...

Subspecies identification of captive Orang Utan in Melaka based on D-loop mitochondria DNA

NASA Astrophysics Data System (ADS)

Kamaluddin, Siti Norsyuhada; Yaakop, Salmah; Idris, Wan Mohd Razi; Rovie-Ryan, Jeffrine Japning; Md-Zain, Badrul Munir

2018-04-01

Mitochondrial DNA of Bornean Orang Utan populations suggests that there are three different subspecies (Pongo pygmaeus pygmaeus; Sarawak & Northwest Kalimantan, P. p. wurmbii; Southern West Kalimantan and Central Kalimantan, P. p. morio; East Kalimantan and Sabah). The subspecies of Orang Utans in captivity are difficult to determine through morphological observation. Thus, misidentification by ranger or zoo staffs leads to unwanted consequences especially towards conservation efforts of Orang Utan. The main objective of this study was to identify the subspecies and the geographic origin of 10 Orang Utans in Zoo Melaka and A' Famosa by using partial mitochondrial D-loop gene sequences. DNA of all individuals was extracted from FTA Card. Data analyses were performed using Maximum Parsimony, MP and Neighbor Joining, NJ. Molecular phylogeny analysis revealed that all the samples likely belong to one species of Sumatran Orang Utan (P. abelii) and three different subspecies of Bornean Orang Utans (P. p. pygmaeus, P. p. morio, and P. p. wurmbii). The results obtained in this study indirectly help the management of zoos in term of conservation and visitor's education.

32. Second floor, hallway, looking north Veterans Administration Center, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

32. Second floor, hallway, looking north - Veterans Administration Center, Officers Duplex Quarters, 5302 East Kellogg (Legal Address); 5500 East Kellogg (Common Address), Wichita, Sedgwick County, KS

22. First floor, staircase, looking east Veterans Administration Center, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. First floor, staircase, looking east - Veterans Administration Center, Officers Duplex Quarters, 5302 East Kellogg (Legal Address); 5500 East Kellogg (Common Address), Wichita, Sedgwick County, KS

Acidification of apple and orange hosts by Penicillium digitatum and Penicillium expansum.

PubMed

Vilanova, L; Viñas, I; Torres, R; Usall, J; Buron-Moles, G; Teixidó, N

2014-05-16

New information about virulence mechanisms of Penicillium digitatum and Penicillium expansum could be an important avenue to control fungal diseases. In this study, the ability of P. digitatum and P. expansum to enhance their virulence by locally modulating the pH of oranges and apples was evaluated. For each host, pH changes with a compatible pathogen and a non-host pathogen were recorded, and the levels of different organic acids were evaluated to establish possible relationships with host pH modifications. Moreover, fruits were harvested at three maturity stages to determine whether fruit maturity could affect the pathogens' virulence. The pH of oranges and apples decreased when the compatible pathogens (P. digitatum and P. expansum, respectively) decayed the fruit. The main organic acid detected in P. digitatum-decayed oranges was galacturonic acid produced as a consequence of host maceration in the rot development process. However, the obtained results showed that this acid was not responsible for the pH decrease in decayed orange tissue. The mixture of malic and citric acids could at least contribute to the acidification of P. digitatum-decayed oranges. The pH decrease in P. expansum decayed apples is related to the accumulation of gluconic and fumaric acids. The pH of oranges and apples was not affected when the non-host pathogen was not able to macerate the tissues. However, different organic acid contents were detected in comparison to healthy tissues. The main organic acids detected in P. expansum-oranges were oxalic and gluconic and in P. digitatum-apples were citric, gluconic and galacturonic. Further research is needed to identify the pathogenicity factors of both fungi because the contribution of organic acids has profound implications. Copyright © 2014 Elsevier B.V. All rights reserved.

Structuring Disaster Recovery Infrastructure Decisions: Lessons from Boulder County's 2013 Flood Recovery

NASA Astrophysics Data System (ADS)

Clavin, C.; Petropoulos, Z.

2017-12-01

Recovery phase decision making processes, as compared to mitigation and response phase decision making processes, require communities make significant financial and capital decisions in the months after a disaster. Collectively, these investments may significantly contribute to the resilience of a community to future hazards. Pre-disaster administrative decisions are well-established within existing planning processes. Post-event recovery requires community decision makers to quickly evaluate technical proposals and manage significant recovery financial resources to ensure their community rebuilds in a manner that will be more resilient to future events. These technical and administrative hurdles in the aftermath of a disaster create a challenging atmosphere to make sound, scientifically-informed decisions leading to resilient recovery. In September 2013, a 1,000-year rain event that resulted in flooding throughout the Front Range of Colorado, significantly impacting Boulder County. While the event is long past, disaster recovery efforts still continue in parts of Boulder County. Boulder County officials formed a county collaborative that adapted the NIST Community Resilience Planning Guide for Buildings and Infrastructure Systems to facilitate a goals-based multi-criteria decision making process. Rather than use hazard-based information to guide infrastructure design, the county's decision process established time-to-recovery goals for infrastructure systems that were used as criteria for project design. This presentation explores the decision-making process employed by Boulder County to specify design standards for resilient rebuilding of infrastructure systems and examine how this infrastructure planning model could be extrapolated to other situations where there is uncertainty regarding future infrastructure design standards.

Improvement of biogas production from orange peel waste by leaching of limonene.

PubMed

Wikandari, Rachma; Nguyen, Huong; Millati, Ria; Niklasson, Claes; Taherzadeh, Mohammad J

2015-01-01

Limonene is present in orange peel wastes and is known as an antimicrobial agent, which impedes biogas production when digesting the peels. In this work, pretreatment of the peels to remove limonene under mild condition was proposed by leaching of limonene using hexane as solvent. The pretreatments were carried out with homogenized or chopped orange peel at 20-40°C with orange peel waste and hexane ratio (w/v) ranging from 1 : 2 to 1 : 12 for 10 to 300 min. The pretreated peels were then digested in batch reactors for 33 days. The highest biogas production was achieved by treating chopped orange peel waste and hexane ratio of 12 : 1 at 20°C for 10 min corresponding to more than threefold increase of biogas production from 0.061 to 0.217 m(3) methane/kg VS. The solvent recovery was 90% using vacuum filtration and needs further separation using evaporation. The hexane residue in the peel had a negative impact on biogas production as shown by 28.6% reduction of methane and lower methane production of pretreated orange peel waste in semicontinuous digestion system compared to that of untreated peel.

Prediction and functional analysis of the sweet orange protein-protein interaction network.

PubMed

Ding, Yu-Duan; Chang, Ji-Wei; Guo, Jing; Chen, Dijun; Li, Sen; Xu, Qiang; Deng, Xiu-Xin; Cheng, Yun-Jiang; Chen, Ling-Ling

2014-08-05

Sweet orange (Citrus sinensis) is one of the most important fruits world-wide. Because it is a woody plant with a long growth cycle, genetic studies of sweet orange are lagging behind those of other species. In this analysis, we employed ortholog identification and domain combination methods to predict the protein-protein interaction (PPI) network for sweet orange. The K-nearest neighbors (KNN) classification method was used to verify and filter the network. The final predicted PPI network, CitrusNet, contained 8,195 proteins with 124,491 interactions. The quality of CitrusNet was evaluated using gene ontology (GO) and Mapman annotations, which confirmed the reliability of the network. In addition, we calculated the expression difference of interacting genes (EDI) in CitrusNet using RNA-seq data from four sweet orange tissues, and also analyzed the EDI distribution and variation in different sub-networks. Gene expression in CitrusNet has significant modular features. Target of rapamycin (TOR) protein served as the central node of the hormone-signaling sub-network. All evidence supported the idea that TOR can integrate various hormone signals and affect plant growth. CitrusNet provides valuable resources for the study of biological functions in sweet orange.

76 FR 18165 - Request for Public Comments Concerning Regulatory Cooperation Activities That Would Help...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-01

... DEPARTMENT OF COMMERCE International Trade Administration Request for Public Comments Concerning Regulatory Cooperation Activities That Would Help Eliminate or Reduce Unnecessary Regulatory Divergences in North America That Disrupt U.S. Exports AGENCY: International Trade Administration, Commerce. ACTION...

Carbon isotope ratios of selected volatiles in Citrus sinensis and in orange-flavoured food.

PubMed

Schipilliti, Luisa; Bonaccorsi, Ivana; Cotroneo, Antonella; Dugo, Paola; Mondello, Luigi

2015-11-01

Twenty genuine samples of industrially cold-pressed sweet orange essential oils, were analysed by gas chromatography-combustion-isotope ratio mass spectrometry to determine the values of the carbon isotope ratios (δ(13)C(VPDB)) of selected volatiles and assess the corresponding range of authenticity. Successively, four commercial orange-flavoured products were analysed under identical conditions to evaluate the authenticity of the orange flavour. The samples were extracted by solid-phase microextraction under optimised conditions. The evaluation was performed by using an internal standard procedure to neglect the contribution due to the original environment to the isotopic abundance of (13)C. The composition of the volatile fraction of the essential oils and of the flavoured products was determined by gas chromatography coupled to mass spectrometry with linear retention indices, and by gas chromatography with a flame ionisation detector. The δ(13)C(VPDB) values of seven secondary metabolites determined here were successfully used to characterise genuine orange essential oil. These values were used to evaluate the quality of orange-flavoured products, revealing the presence of compounds of different origin, not compatible with the values of genuine orange secondary metabolites. This study provides the range of authenticity of δ(13)C(VPDB) of seven different secondary metabolites in sweet orange genuine essential oil, useful for evaluating the genuineness of orange flavour. In accord with a previous study on different essential oils, the values determined here can be successfully applied for the evaluation of a large number of flavoured food stuffs and correlated with their origins. © 2014 Society of Chemical Industry.

15. First floor, south wall, looking south Veterans Administration ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. First floor, south wall, looking south - Veterans Administration Center, Officers Duplex Quarters, 5302 East Kellogg (Legal Address); 5500 East Kellogg (Common Address), Wichita, Sedgwick County, KS

14. First floor, west wall, looking south Veterans Administration ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. First floor, west wall, looking south - Veterans Administration Center, Officers Duplex Quarters, 5302 East Kellogg (Legal Address); 5500 East Kellogg (Common Address), Wichita, Sedgwick County, KS

34. Attic, from folding ladder, looking north Veterans Administration ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

34. Attic, from folding ladder, looking north - Veterans Administration Center, Officers Duplex Quarters, 5302 East Kellogg (Legal Address); 5500 East Kellogg (Common Address), Wichita, Sedgwick County, KS

37. Attic, south wall, detail of radiator Veterans Administration ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

37. Attic, south wall, detail of radiator - Veterans Administration Center, Officers Duplex Quarters, 5302 East Kellogg (Legal Address); 5500 East Kellogg (Common Address), Wichita, Sedgwick County, KS

78 FR 28115 - Oranges, Grapefruit, Tangerines, and Tangelos Grown in Florida; Relaxing Size and Grade...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-14

... Requirements on Valencia and Other Late Type Oranges AGENCY: Agricultural Marketing Service, USDA. ACTION...). This rule reduces the minimum size requirement for Valencia and other late type oranges shipped to... also reduces the minimum grade requirement for Valencia and other late type oranges shipped to...

Orange interventions for symptoms associated with dimethyl sulfoxide during stem cell reinfusions: a feasibility study.

PubMed

Potter, Pamela; Eisenberg, Seth; Cain, Kevin C; Berry, Donna L

2011-01-01

For over 2 decades, oncology nurses at a regional comprehensive cancer center offered sliced oranges to patients during the reinfusion of autologous hematopoietic progenitor cells (HPCs) to relieve symptoms associated with the preservative dimethyl sulfoxide (DMSO). This randomized pilot study examined feasibility and efficacy of sliced orange intervention (OI), orange aromatherapy intervention (OAI), or deep breathing (control) to address unpleasant adverse effects during HPC infusion. Orange intervention sniffed or tasted a quartered orange, OAI sniffed orange aromatherapy, and control took deep breaths. Perceived "symptom intensity" for tickle/cough urge, nausea, retching, and perceived "relief" were measured on 0- to 10-point numerical scales. Sixty of 72 eligible patients consented to participate and were randomized to OI (n = 19), OAI (n = 23), or control (n = 18). Study personnel successfully administered study procedures. Over the course of 2 bags of cells infused, the OI group reported significantly greater relief with the intervention (P = .032). Among participants less than 90 kg, OI group reported significantly lower symptom intensity (P = .012). Results suggest a feasible protocol and potential efficacy of sliced oranges for treating symptoms associated with DMSO-preserved stem cells. Study procedures provide a tested protocol for future studies. Follow-up study is warranted to confirm these findings and evaluate other treatment options. Oranges offer a simple, noninvasive intervention for relieving symptoms associated with DMSO preservative during autologous HPC infusion.

76 FR 16852 - Public Notice for Waiver of Aeronautical Land-Use Assurance; Marv Skie-Lincoln County Airport...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-25

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Public Notice for Waiver of Aeronautical Land-Use Assurance; Marv Skie-Lincoln County Airport; Tea, SD AGENCY: Federal Aviation... the Marv Skie-Lincoln County Airport, Tea, South Dakota. The proposal consists of the trade of...

77 FR 4617 - Environmental Impact Statement: Pennington County, SD

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-30

...: Pennington County, SD AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of Intent. SUMMARY..., Suite A, Pierre, SD 57501, (605) 226-7326; Mr. Terry Keller, Environmental Supervisor, Project Development, South Dakota Department of Transportation, 700 E. Broadway Avenue, Pierre, SD 57501, (605) 773...

78 FR 52079 - Oranges, Grapefruit, Tangerines, and Tangelos Grown in Florida; Relaxing Size and Grade...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-22

... Requirements on Valencia and Other Late Type Oranges AGENCY: Agricultural Marketing Service, USDA. ACTION...). The interim rule reduced the minimum size for Valencia and other late type oranges shipped to... interim rule also lowered the minimum grade for Valencia and other late type oranges shipped to interstate...

Orange juice modulates proinflammatory cytokines after high-fat saturated meal consumption.

PubMed

Rocha, Daniela M U P; Lopes, Lílian L; da Silva, Alessandra; Oliveira, Leandro L; Bressan, Josefina; Hermsdorff, Helen Hermana M

2017-12-13

We aimed to evaluate the postprandial secretion of inflammatory markers induced by SFA or MUFA high-fat meal consumption and whether orange juice intake could modulate this induction. This study included 55 healthy women (aged 20 to 40 years): 33 participants received an SFA high-fat meal (≈1000 kcal, 37.6% of energy intake (E) from SFA) and 22 participants received an MUFA high-fat meal (≈1000 kcal, 56.3% E from MUFA). Both interventions were accompanied by 500 ml of orange juice (test) or water (control). The plasma concentrations of inflammatory cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-γ, and TNF-α) and CRP were determined before (fasting) and 2, 3 and 5 hours after the test meal intake. The SFA high-fat meal induced a significant increase in AUC values (for TNF-α, IL-12, IL-10, IL-6 and IL-2 adjusted for baseline concentrations) in comparison with MUFA high-fat meal intervention. The results were independent of the drink which accompanied the meal (water or orange juice). Both IL-4 and IL-17A AUC values were significantly increased after an SFA high-fat meal intake, accompanied by water, but not by orange juice. In addition, these values were higher in relation to MUFA high-fat meal interventions. Also, IL-17A significantly increased at 3 h after an SFA high-fat meal intake accompanied by water, but not by orange juice. Overall, our conclusions indicate an anti-inflammatory effect of MUFA compared to SFA high-fat meal intake, while orange juice intake was able to mitigate the subclinical increase of postprandial inflammation, induced by SFA high-fat meal consumption, for a particular biomarker (IL-17A).

Orange-Pigmented Sputum as a Manifestation of Smoke Grenade Inhalation Injury.

PubMed

Chatzivasiloglou, Fotini; Katsenos, Stamatis; Psara, Anthoula; Tsintiris, Konstantinos

2016-01-01

A 34-year-old man presented with scanty hemoptysis, orange-colored expectoration, and mild dyspnea. He was in an enclosed building taking part in a military training exercise inhaling an orange-colored smoke from a smoke grenade ignition. His symptoms developed immediately after the initial exposure but he sought medical assistance 20 hours later because of their persistence. Fiberoptic bronchoscopy was performed revealing diffuse inflammatory tracheobronchial tree with streaky orange-pigmented secretions in the trachea and both main-stem bronchi. Acute tracheobronchitis was diagnosed and the patient was treated with nebulized bronchodilators and intravenous corticosteroids showing complete recovery. To our knowledge, this is the first well-documented report of inhalation injury induced by a smoke bomb explosion including potassium chlorate oxidizer and Sudan I and presenting with orange-pigmented sputum production. Smoke inhalation injury is associated with significant morbidity and mortality. The heterogeneity of the smoke and the large variety of the resulting symptoms may be the reason why a definition, specific diagnostic criteria, and therapeutic guidelines are still lacking.

Toxic Epidemics: Agent Orange Sickness in Vietnam and the United States.

PubMed

Uesugi, Tak

2016-01-01

Social scientists studying toxic epidemics have often endeavored to shed light on the differences between scientists' and nonscientists' epistemic perspectives. Yet, little attention has been paid to the processes through which a toxic epidemic emerges as a phenomenon. A Luoi Valley of Central Vietnam was extensively sprayed with chemical defoliants (including Agent Orange) during the Vietnam War. The latent toxic effects of these chemicals, however, went largely unnoticed until the late 1990s. By juxtaposing the history through which the notion of "Agent Orange Sickness" emerged in the United States with an ethnographic study of A Luoi, I explore the notion of poison under which Agent Orange became recognizable as a poison.

National Credit Union Administration Semiannual Regulatory Agenda

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-26

... only the minimum required burdens on credit unions, consumers, and the public; are appropriate for the... Administration--Completed Actions Regulation Sequence Title Identifier Number Number 412 Privacy of Consumer... Actions 412. PRIVACY OF CONSUMER FINANCIAL INFORMATION Legal Authority: 15 USC 6801 et seq Abstract: NCUA...

A bright cyan-excitable orange fluorescent protein facilitates dual-emission microscopy and enhances bioluminescence imaging in vivo

PubMed Central

Chu, Jun; Oh, Young-Hee; Sens, Alex; Ataie, Niloufar; Dana, Hod; Macklin, John J.; Laviv, Tal; Welf, Erik S.; Dean, Kevin M.; Zhang, Feijie; Kim, Benjamin B.; Tang, Clement Tran; Hu, Michelle; Baird, Michelle A.; Davidson, Michael W.; Kay, Mark A.; Fiolka, Reto; Yasuda, Ryohei; Kim, Douglas S.; Ng, Ho-Leung; Lin, Michael Z.

2016-01-01

Orange-red fluorescent proteins (FPs) are widely used in biomedical research for multiplexed epifluorescence microscopy with GFP-based probes, but their different excitation requirements make multiplexing with new advanced microscopy methods difficult. Separately, orange-red FPs are useful for deep-tissue imaging in mammals due to the relative tissue transmissibility of orange-red light, but their dependence on illumination limits their sensitivity as reporters in deep tissues. Here we describe CyOFP1, a bright engineered orange-red FP that is excitable by cyan light. We show that CyOFP1 enables single-excitation multiplexed imaging with GFP-based probes in single-photon and two-photon microscopy, including time-lapse imaging in light-sheet systems. CyOFP1 also serves as an efficient acceptor for resonance energy transfer from the highly catalytic blue-emitting luciferase NanoLuc. An optimized fusion of CyOFP1 and NanoLuc, called Antares, functions as a highly sensitive bioluminescent reporter in vivo, producing substantially brighter signals from deep tissues than firefly luciferase and other bioluminescent proteins. PMID:27240196

Effects of tooth whitening and orange juice on surface properties of dental enamel.

PubMed

Ren, Yan-Fang; Amin, Azadeh; Malmstrom, Hans

2009-06-01

To study the effects of 6% H2O2 activated with LED light on surface enamel as compared to orange juice challenges in vitro. A total of 40 human enamel discs were incubated in saliva overnight to allow pellicle formation and then divided into three groups: 15 for whitening treatments, 15 for orange juice immersions and 10 for normal saline controls. Baseline microhardness was measured with a microhardness Knoop indenter (50g, 10s) and surface topography was evaluated with a focus-variation 3D scanning microscopy. Enamel discs were treated with H2O2 or orange juice for 20 min each cycle for five cycles to simulate daily treatment with the products for 5 days. The discs were stored in saliva between treatment cycles. Microhardness and surface topography were evaluated again after treatments. Changes in microhardness and in surface area roughness (Sa), mean maximum peak-to-valley distance (Sz) and the developed surface area ratio (Sdr) were compared before and after treatments (t-test) and among groups (ANOVA). Enamel surface hardness decreased by 84% after orange juice immersion but no statistically significant changes were observed in the whitening and control groups. Surface topography changed significantly only in the orange juice group as shown by increased Sa (1.2 microm vs. 2.0 microm), Sz (7.7 microm vs. 10.2 microm) and Sdr (2.8% vs. 6.0%). No such changes were observed in the whitening and control groups. In comparison to orange juice challenges, the effects of 6% H2O2 on surface enamel are insignificant. Orange juice erosion markedly decreased hardness and increased roughness of enamel.

Agent Orange exposure and attributed health effects in Vietnam veterans.

PubMed

Young, Alvin L; Cecil, Paul F

2011-07-01

Serum dioxin studies of Vietnam (VN) veterans, military historical records of tactical herbicide use in Vietnam, and the compelling evidence of the photodegradation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other aspects of environmental fate and low bioavailability of TCDD are consistent with few, if any, ground troop veterans being exposed to Agent Orange. That conclusion, however, is contrary to the presumption by the Department of Veterans Affairs (DVA) that military service in Vietnam anytime from January 9, 1962 to May 7, 1975 is a proxy for exposure to Agent Orange. The DVA assumption is inconsistent with the scientific principles governing determinations of disease causation. The DVA has nonetheless awarded Agent Orange-related benefits and compensation to an increasing number of VN veterans based on the presumption of exposure and the published findings of the Institute of Medicine that there is sufficient evidence of a "statistical association" (a less stringent standard than "causal relationship") between exposure to tactical herbicides or TCDD and 15 different human diseases. A fairer and more valid approach for VN veterans would have been to enact a program of "Vietnam experience" benefits for those seriously ill, rather than benefits based on the dubious premise of injuries caused by Agent Orange.

The monoterpene limonene in orange peels attracts pests and microorganisms

PubMed Central

Rodríguez, Ana; Andrés, Victoria San; Cervera, Magdalena; Redondo, Ana; Alquézar, Berta; Shimada, Takehiko; Gadea, José; Rodrigo, María; Zacarías, Lorenzo; Palou, Lluís; López, María M.; Castañera, Pedro; Peña, Leandro

2011-01-01

Plant volatiles include terpenoids, which are generally involved in plant defense, repelling pests and pathogens and attracting insects for herbivore control, pollination and seed dispersal. Orange fruits accumulate the monoterpene limonene at high levels in the oil glands of their fruit peels. When limonene production was downregulated in orange fruits by the transgenic expression of a limonene synthase (CitMTSE1) in the antisense configuration, these fruits were resistant to the fungus Penicillium digitatum (Pers.) Sacc. and the bacterium Xanthomonas citri subsp. citri and were less attractive to the medfly pest Ceratitis capitata. These responses were reversed when the antisense transgenic orange fruits were treated with limonene. To gain more insight into the role of the limonene concentration in fruit responses to pests and pathogens, we attempted to overexpress CitMTSE1 in the sense configuration in transgenic orange fruits. Only slight increases in the amount of limonene were found in sense transgenic fruits, maybe due to the detrimental effect that excessive limonene accumulation would have on plant development. Collectively, these results suggest that when limonene reaches peak levels as the fruit develops, it becomes a signal for pest and pathogen attraction, which facilitate access to the fruit for pulp consumers and seed dispersers. PMID:22212123

13 CFR 108.585 - Voluntary decrease in NMVC Company's Regulatory Capital.

Code of Federal Regulations, 2010 CFR

2010-01-01

...'s Regulatory Capital. 108.585 Section 108.585 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NEW MARKETS VENTURE CAPITAL (âNMVCâ) PROGRAM Managing the Operations of a NMVC Company Voluntary Decrease in Regulatory Capital § 108.585 Voluntary decrease in NMVC Company's Regulatory Capital. You must...

Improvement of Biogas Production from Orange Peel Waste by Leaching of Limonene

PubMed Central

Wikandari, Rachma; Nguyen, Huong; Millati, Ria; Niklasson, Claes; Taherzadeh, Mohammad J.

2015-01-01

Limonene is present in orange peel wastes and is known as an antimicrobial agent, which impedes biogas production when digesting the peels. In this work, pretreatment of the peels to remove limonene under mild condition was proposed by leaching of limonene using hexane as solvent. The pretreatments were carried out with homogenized or chopped orange peel at 20–40°C with orange peel waste and hexane ratio (w/v) ranging from 1 : 2 to 1 : 12 for 10 to 300 min. The pretreated peels were then digested in batch reactors for 33 days. The highest biogas production was achieved by treating chopped orange peel waste and hexane ratio of 12 : 1 at 20°C for 10 min corresponding to more than threefold increase of biogas production from 0.061 to 0.217 m3 methane/kg VS. The solvent recovery was 90% using vacuum filtration and needs further separation using evaporation. The hexane residue in the peel had a negative impact on biogas production as shown by 28.6% reduction of methane and lower methane production of pretreated orange peel waste in semicontinuous digestion system compared to that of untreated peel. PMID:25866787

Metabolomic comparative analysis of the phloem sap of curry leaf tree (Bergera koenegii), orange jasmine (Murraya paniculata), and Valencia sweet orange (Citrus sinensis) supports their differential responses to Huanglongbing

PubMed Central

Killiny, Nabil

2016-01-01

ABSTRACT Orange jasmine, Murraya paniculata and curry leaf tree, Bergera koenegii are alternative hosts for Diaphorina citri, the vector of Candidatus Liberibacter asiaticus (CLas), the pathogen of huanglongbing (HLB) in citrus. D. citri feeds on the phloem sap where CLas grows. It has been shown that orange jasmine was a better host than curry leaf tree to D. citri. In addition, CLas can infect orange jasmine but not curry leaf tree. Here, we compared the phloem sap composition of these 2 plants to the main host, Valencia sweet orange, Citrus sinensis. Phloem sap was analyzed by gas chromatography-mass spectrometry after trimethylsilyl derivatization. Orange jasmine was the highest in proteinogenic, non-proteinogenic amino acids, organic acids, as well as total metabolites. Valencia was the highest in mono- and disaccharides, and sugar alcohols. Curry leaf tree was the lowest in most of the metabolites as well as total metabolites. Interestingly, malic acid was high in Valencia and orange jasmine but was not detected in the curry leaf. On the other hand, tartaric acid which can prevent the formation of malic acid in Krebs cycle was high in curry leaf. The nutrient inadequacy of the phloem sap in curry leaf tree, especially the amino acids could be the reason behind the longer life cycle and the low survival of D. citri and the limitation of CLas growth on this host. Information obtained from this study may help in cultivation of CLas and development of artificial diet for rearing of D. citri. PMID:27763819

Metabolomic comparative analysis of the phloem sap of curry leaf tree (Bergera koenegii), orange jasmine (Murraya paniculata), and Valencia sweet orange (Citrus sinensis) supports their differential responses to Huanglongbing.

PubMed

Killiny, Nabil

2016-11-01

Orange jasmine, Murraya paniculata and curry leaf tree, Bergera koenegii are alternative hosts for Diaphorina citri, the vector of Candidatus Liberibacter asiaticus (CLas), the pathogen of huanglongbing (HLB) in citrus. D. citri feeds on the phloem sap where CLas grows. It has been shown that orange jasmine was a better host than curry leaf tree to D. citri. In addition, CLas can infect orange jasmine but not curry leaf tree. Here, we compared the phloem sap composition of these 2 plants to the main host, Valencia sweet orange, Citrus sinensis. Phloem sap was analyzed by gas chromatography-mass spectrometry after trimethylsilyl derivatization. Orange jasmine was the highest in proteinogenic, non-proteinogenic amino acids, organic acids, as well as total metabolites. Valencia was the highest in mono- and disaccharides, and sugar alcohols. Curry leaf tree was the lowest in most of the metabolites as well as total metabolites. Interestingly, malic acid was high in Valencia and orange jasmine but was not detected in the curry leaf. On the other hand, tartaric acid which can prevent the formation of malic acid in Krebs cycle was high in curry leaf. The nutrient inadequacy of the phloem sap in curry leaf tree, especially the amino acids could be the reason behind the longer life cycle and the low survival of D. citri and the limitation of CLas growth on this host. Information obtained from this study may help in cultivation of CLas and development of artificial diet for rearing of D. citri.

[Orange Platform].

PubMed

Toba, Kenji

2017-07-01

The Organized Registration for the Assessment of dementia on Nationwide General consortium toward Effective treatment in Japan (ORANGE platform) is a recently established nationwide clinical registry for dementia. This platform consists of multiple registries of patients with dementia stratified by the following clinical stages: preclinical, mild cognitive impairment, early-stage, and advanced-stage dementia. Patients will be examined in a super-longitudinal fashion, and their lifestyle, social background, genetic risk factors, and required care process will be assessed. This project is also notable because the care registry includes information on the successful, comprehensive management of patients with dementia. Therefore, this multicenter prospective cohort study will contribute participants to all clinical trials for Alzheimer's disease as well as improve the understanding of individuals with dementia.

Fitzsimons General Hospital, Women's Army Corps Recreation & Administration Building, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Fitzsimons General Hospital, Women's Army Corps Recreation & Administration Building, North Hickey Street, west side, 75 feet north of intersection of West Pennington Avenue & North Hickey Street, Aurora, Adams County, CO

Credit BG. View looks north northwest (325°) towards Administration Building ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Credit BG. View looks north northwest (325°) towards Administration Building across aircraft apron east of Building 4505. Building 4507 (Storage Building) appears at extreme right of view - Edwards Air Force Base, North Base, Administration Building, Northeast of A Street, Boron, Kern County, CA

78 FR 59919 - Pershing County Water Conservation District; Notice of Application Accepted for Filing With the...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-30

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 14327-000] Pershing County Water Conservation District; Notice of Application Accepted for Filing With the Commission, Intent to Waive Scoping, Soliciting Motions to Intervene and Protests, Ready For Environmental Analysis, and Soliciting Comments, Terms and Conditions,...

Glyphosate Control of Orange and Brown Rusts in Glyphosate-Sensitive Sugarcane Cultivars

USDA-ARS?s Scientific Manuscript database

Technical Abstract: Brown and orange rust diseases cause substantial yield reductions on sugarcane (Saccharum spp.) in Florida and other regions where sugarcane is grown. Brown rust caused by Puccinia melanocephala Syd. & P. Syd has been present in Florida since 1978 and orange rust caused by Pucci...

Recentralization within decentralization: County hospital autonomy under devolution in Kenya

PubMed Central

Manyara, Anthony M.; Molyneux, Sassy; Tsofa, Benjamin

2017-01-01

Background In 2013, Kenya transitioned into a devolved system of government with a central government and 47 semi-autonomous county governments. In this paper, we report early experiences of devolution in the Kenyan health sector, with a focus on public county hospitals. Specifically, we examine changes in hospital autonomy as a result of devolution, and how these have affected hospital functioning. Methods We used a qualitative case study approach to examine the level of autonomy that hospitals had over key management functions and how this had affected hospital functioning in three county hospitals in coastal Kenya. We collected data by in-depth interviews of county health managers and hospital managers in the case study hospitals (n = 21). We adopted the framework proposed by Chawla et al (1995) to examine the autonomy that hospitals had over five management domains (strategic management, finance, procurement, human resource, and administration), and how these influenced hospital functioning. Findings Devolution had resulted in a substantial reduction in the autonomy of county hospitals over the five key functions examined. This resulted in weakened hospital management and leadership, reduced community participation in hospital affairs, compromised quality of services, reduced motivation among hospital staff, non-alignment of county and hospital priorities, staff insubordination, and compromised quality of care. Conclusion Increasing the autonomy of county hospitals in Kenya will improve their functioning. County governments should develop legislation that give hospitals greater control over resources and key management functions. PMID:28771558

Effect of fermentation and subsequent pasteurization processes on amino acids composition of orange juice.

PubMed

Cerrillo, I; Fernández-Pachón, M S; Collado-González, J; Escudero-López, B; Berná, G; Herrero-Martín, G; Martín, F; Ferreres, F; Gil-Izquierdo, A

2015-06-01

The fermentation of fruit produces significant changes in their nutritional composition. An orange beverage has been obtained from the controlled alcoholic fermentation and thermal pasteurization of orange juice. A study was performed to determine the influence of both processes on its amino acid profile. UHPLC-QqQ-MS/MS was used for the first time for analysis of orange juice samples. Out of 29 amino acids and derivatives identified, eight (ethanolamine, ornithine, phosphoethanolamine, α-amino-n-butyric acid, hydroxyproline, methylhistidine, citrulline, and cystathionine) have not previously been detected in orange juice. The amino acid profile of the orange juice was not modified by its processing, but total amino acid content of the juice (8194 mg/L) was significantly increased at 9 days of fermentation (13,324 mg/L). Although the pasteurization process produced partial amino acid degradation, the total amino acid content was higher in the final product (9265 mg/L) than in the original juice, enhancing its nutritional value.

Limonoid content of sour orange varieties

USDA-ARS?s Scientific Manuscript database

Modern Citrus cultivars are thought to have arisen from three parents- the (pummelo), the mandarin, and citron. Taxological and genetic data support that sweet and sour oranges share a common parentage. However, as their name suggests the organoleptic properties of the fruit from these two familie...

Agent Orange exposure and cancer incidence in Korean Vietnam veterans: a prospective cohort study.

PubMed

Yi, Sang-Wook; Ohrr, Heechoul

2014-12-01

During the Vietnam War, US and allied military sprayed approximately 77 million liters of tactical herbicides including Agent Orange, contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. To the authors' knowledge, few studies to date have examined the association between Agent Orange exposure and cancer incidence among Korean veterans who were exposed to Agent Orange during the Vietnam War. An Agent Orange exposure index, based on the proximity of the veteran's military unit to the area that was sprayed with Agent Orange, was developed using a geographic information system-based model. Cancer incidence was followed for 180,251 Vietnam veterans from 1992 through 2003. After adjustment for age and military rank, high exposure to Agent Orange was found to significantly increase the risk of all cancers combined (adjusted hazards ratio [aHR], 1.08). Risks for cancers of the mouth (aHR, 2.54), salivary glands (aHR, 6.96), stomach (aHR, 1.14), and small intestine (aHR, 2.30) were found to be significantly higher in the high-exposure group compared with the low-exposure group. Risks for cancers of all sites combined (aHR, 1.02) and for cancers of the salivary glands (aHR, 1.47), stomach (aHR, 1.03), small intestine (aHR, 1.24), and liver (aHR, 1.02) were elevated with a 1-unit increase in the exposure index. Exposure to Agent Orange several decades earlier may increase the risk of cancers in all sites combined, as well as several specific cancers, among Korean veterans of the Vietnam War, including some cancers that were not found to be clearly associated with exposure to Agent Orange in previous cohort studies primarily based on Western populations. © 2014 American Cancer Society.

Impact of patient-centered medical home assignment on emergency room visits among uninsured patients in a county health system.

PubMed

Roby, Dylan H; Pourat, Nadereh; Pirritano, Matthew J; Vrungos, Shelley M; Dajee, Himmet; Castillo, Dan; Kominski, Gerald F

2010-08-01

The Medical Services Initiative program--a safety net-based system of care--in Orange County included assignment of uninsured, low-income residents to a patient-centered medical home. The medical home provided case management, a team-based approach for treating disease, and increased access to primary and specialty care among other elements of a patient-centered medical home. Providers were paid an enhanced fee and pay-for-performance incentives to ensure delivery of comprehensive treatment. Medical Services Initiative enrollees who were assigned to a medical home for longer time periods were less likely to have any emergency room (ER) visits or multiple ER visits. Switching medical homes three or more times was associated with enrollees being more likely to have any ER visits or multiple ER visits. The findings provide evidence that successful implementation of the patient-centered medical home model in a county-based safety net system is possible and can reduce unnecessary ER use.

76 FR 36613 - Environmental Impact Statement; Nueces County, TX

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-22

... County, TX AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of Intent (NOI). SUMMARY... (TxDOT) are issuing this notice to advise the public that an environmental impact statement (EIS) will...--Texas Division, 300 East 8th Street, Austin, Texas 78701. Telephone: 512-536-5960. SUPPLEMENTARY...

Estimated land-surface subsidence in Harris County, Texas, 1915-17 to 2001

USGS Publications Warehouse

Kasmarek, Mark C.; Gabrysch, Robert K.; Johnson, Michaela R.

2009-01-01

Land-surface subsidence, or land subsidence, in Harris County, Texas, which encompasses much of the Houston area, has been occurring for decades. Land subsidence has increased the frequency and extent of flooding, damaged buildings and transportation infrastructure, and caused adverse environmental effects. The primary cause of land subsidence in the Houston area is withdrawal of groundwater, although extraction of oil and gas also has contributed. Throughout most of the 20th century, groundwater was the primary source of municipal, agricultural, and industrial water supply for Harris County. Currently (2009) a transition to surface water as the primary source of supply, guided by a groundwater regulatory plan developed by the Harris-Galveston Subsidence District (2001), is in effect. The aquifers in Harris County contain an abundant amount of potable groundwater, but they also contain layers of clay. Groundwater withdrawals caused compaction of the clay layers, which in turn resulted in the widespread, substantial land-surface subsidence that has occurred in the Houston area.

Effects of administrative license revocation on employment.

PubMed

Knoebel, K Y; Ross, H L

1997-09-01

This study addresses the impact of administrative license revocation (ALR) on the employment and income of first and multiple drunk-driving (DUI) offenders. It also inquires into the impact of alcohol-related crashes on the employment of other persons involved in such crashes (i.e. innocent drivers, passengers and pedestrians). Questionnaires were completed by 579 first-time offenders and 233 multiple offenders at alcohol education schools and treatment programs in four counties in four states, which represented varying ALR laws: Chester County, PA (without ALR); Anne Arundel County, MD (ALR with immediate hardship license available); Marin County, CA (30-day hard license suspension); and New Castle County, DE (90-day hard license suspension). Completed crash 'victim' surveys were returned by 146 crash victims from Pennsylvania, California and Delaware. The study found that ALR does not have a major impact on the DUI offender's job and income. Alcohol-involved crashes can have a great impact on seriously injured victims, but the proportion of DUI crashes producing serious injury is quite low. Most DUI is crash-free, and most crashes do not involve injury. The vast bulk of the impact of DUI events falls on the offenders rather than innocent victims.

Increased risks of cardiovascular diseases and insulin resistance among the Orang Asli in Peninsular Malaysia.

PubMed

Tuan Abdul Aziz, Tuan Azlin; Teh, Lay Kek; Md Idris, Muhd Hanis; Bannur, Zakaria; Ashari, Lydiatul Shima; Ismail, Adzrool Idzwan; Ahmad, Aminuddin; Isa, Kamarudzaman Md; Nor, Fadzilah Mohd; Rahman, Thuhairah Hasrah Abdul; Shaari, Syahrul Azlin Binti; Jan Mohamed, Hamid Jan; Mohamad, Nornazliya; Salleh, Mohd Zaki

2016-03-24

Despite the strategic development plan by the authorities for the Orang Asli, there are six subtribes of which their population numbers are small (less than 700). These minorities were not included in most of the health related studies published thus far. A comprehensive physiological and biomedical updates on these small subtribes in comparison to the larger subtribes and the urban Malay population is timely and important to help provide appropriate measures to prevent further reduction in the numbers of the Orang Asli. A total of 191 Orang Asli from different villages in Peninsular Malaysia and 115 healthy urban Malays were recruited. Medical examinations and biochemical analyses were conducted. Framingham risk scores were determined. Data was analyzed using IBM SPSS Statistics, Version 20.0. A higher percentage of the Orang Asli showed high insulin levels and hsCRP compared to the healthy Malays denoting possible risk of insulin resistance. High incidences of low HDL-c levels were observed in all the Orang Asli from the six subtribes but none was detected among the urban Malays. A higher percentage of inlanders (21.1% of the males and 4.2% of the females) were categorized to have high Framingham Risk Score. Orang Asli staying both in the inlands and peripheries are predisposed to cardiovascular diseases and insulin resistance diabetes mellitus. The perception of Orang Asli being healthier than the urban people no longer holds. We believed that this information is important to the relevant parties in strategizing a healthier community of the Orang Asli to avoid the vanishing of the vulnerable group(s).

Ratiometric analysis of Acridine Orange staining in the study of acidic organelles and autophagy.

PubMed

Thomé, Marcos P; Filippi-Chiela, Eduardo C; Villodre, Emilly S; Migliavaca, Celina B; Onzi, Giovana R; Felipe, Karina B; Lenz, Guido

2016-12-15

Acridine Orange is a cell-permeable green fluorophore that can be protonated and trapped in acidic vesicular organelles (AVOs). Its metachromatic shift to red fluorescence is concentration-dependent and, therefore, Acridine Orange fluoresces red in AVOs, such as autolysosomes. This makes Acridine Orange staining a quick, accessible and reliable method to assess the volume of AVOs, which increases upon autophagy induction. Here, we describe a ratiometric analysis of autophagy using Acridine Orange, considering the red-to-green fluorescence intensity ratio (R/GFIR) to quantify flow cytometry and fluorescence microscopy data of Acridine-Orange-stained cells. This method measured with accuracy the increase in autophagy induced by starvation or rapamycin, and the reduction in autophagy produced by bafilomycin A1 or the knockdown of Beclin1 or ATG7. Results obtained with Acridine Orange, considering R/GFIR, correlated with the conversion of the unlipidated form of LC3 (LC3-I) into the lipidated form (LC3-II), SQSTM1 degradation and GFP-LC3 puncta formation, thus validating this assay to be used as an initial and quantitative method for evaluating the late step of autophagy in individual cells, complementing other methods. © 2016. Published by The Company of Biologists Ltd.

78 FR 20664 - 2013 Medical Countermeasures Initiative Regulatory Science Symposium

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-05

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0001] 2013 Medical Countermeasures Initiative Regulatory Science Symposium AGENCY: Food and Drug... following meeting: 2013 Medical Countermeasures initiative (MCMi) Regulatory Science Symposium. The...

Detection of mandarin in orange juice by single-nucleotide polymorphism qPCR assay.

PubMed

Aldeguer, Miriam; López-Andreo, María; Gabaldón, José A; Puyet, Antonio

2014-02-15

A dual-probe real time PCR (qPCR) DNA-based analysis was devised for the identification of mandarin in orange juice. A single nucleotide polymorphism at the trnL-trnF intergenic region of the chloroplast chromosome was confirmed in nine orange (Citrus sinensis) and thirteen commercial varieties of mandarin, including Citrus reticulata and Citrus unshiu species and a mandarin × tangelo hybrid. Two short minor-groove binding fluorescent probes targeting the polymorphic sequence were used in the dual-probe qPCR, which allowed the detection of both species in single-tube reactions. The similarity of PCR efficiencies allowed a simple estimation of the ratio mandarin/orange in the juice samples, which correlated to the measured difference of threshold cycle values for both probes. The limit of detection of the assay was 5% of mandarin in orange juice, both when the juice was freshly prepared (not from concentrate) or reconstituted from concentrate, which would allow the detection of fraudulently added mandarin juice. The possible use of the dual-probe system for quantitative measurements was also tested on fruit juice mixtures. qPCR data obtained from samples containing equal amounts of mandarin and orange juice revealed that the mandarin target copy number was approximately 2.6-fold higher than in orange juice. The use of a matrix-adapted control as calibrator to compensate the resulting C(T) bias allowed accurate quantitative measurements to be obtained. Copyright © 2013 Elsevier Ltd. All rights reserved.

75 FR 32479 - Determination of Regulatory Review Period for Purposes of Patent Extension; ABLAVAR

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket Nos. FDA-2009-E-0165 and FDA-2009-E-0169] Determination of Regulatory Review Period for Purposes of Patent Extension... Administration (FDA) has determined the regulatory review period for ABLAVAR (previously the trade name of the...

Effect of land-applied biosolids on surface-water nutrient yields and groundwater quality in Orange County, North Carolina

USGS Publications Warehouse

Wagner, Chad R.; Fitzgerald, Sharon A.; McSwain, Kristen Bukowski; Harden, Stephen L.; Gurley, Laura N.; Rogers, Shane W.

2015-01-01

The data, analysis, and conclusions associated with this study can be used by regulatory agencies, resource managers, and wastewater-treatment operators to (1) better understand the quantity and characteristics of nutrients, bacteria, metals, and contaminants of emerging concern that are transported away from biosolids land-application fields to surface water and groundwater under current regulations for the purposes of establishing effective total maximum daily loads (TMDLs) and restoring impaired water resources, (2) assess how well existing regulations protect waters of the State and potentially recommend effective changes to regulations or land-application procedures, and (3) establish a framework for developing guidance on effective techniques for monitoring and regulatory enforcement of permitted biosolids land-application fields.

Red Orange: Experimental Models and Epidemiological Evidence of Its Benefits on Human Health

PubMed Central

Galvano, Fabio; Mistretta, Antonio; Marventano, Stefano; Nolfo, Francesca; Calabrese, Giorgio; Buscemi, Silvio; Drago, Filippo; Veronesi, Umberto; Scuderi, Alessandro

2013-01-01

In recent years, there has been increasing public interest in plant antioxidants, thanks to the potential anticarcinogenic and cardioprotective actions mediated by their biochemical properties. The red (or blood) orange (Citrus sinensis (L.) Osbeck) is a pigmented sweet orange variety typical of eastern Sicily (southern Italy), California, and Spain. In this paper, we discuss the main health-related properties of the red orange that include anticancer, anti-inflammatory, and cardiovascular protection activities. Moreover, the effects on health of its main constituents (namely, flavonoids, carotenoids, ascorbic acid, hydroxycinnamic acids, and anthocyanins) are described. The red orange juice demonstrates an important antioxidant activity by modulating many antioxidant enzyme systems that efficiently counteract the oxidative damage which may play an important role in the etiology of numerous diseases, such as atherosclerosis, diabetes, and cancer. The beneficial effects of this fruit may be mediated by the synergic effects of its compounds. Thus, the supply of natural antioxidant compounds through a balanced diet rich in red oranges might provide protection against oxidative damage under differing conditions and could be more effective than, the supplementation of an individual antioxidant. PMID:23738032

Suicide Among Military Personnel and Veterans Aged 18-35 Years by County-16 States.

PubMed

Logan, Joseph E; Fowler, Katherine A; Patel, Nimeshkumar P; Holland, Kristin M

2016-11-01

Suicide among military personnel and young Veterans remains a health concern. This study examined stateside distribution of suicides by U.S. county to help focus prevention efforts. Using 2005-2012 National Violent Death Reporting System data from 16 states (963 counties, or county-equivalent entities), this study mapped the county-level distribution of suicides among current military and Veteran decedents aged 18-35 years. This study also compared incident circumstances of death between decedents in high-density counties (i.e., counties with the highest proportion of deaths) versus those in medium/low-density counties to better understand the precipitators of suicide in counties most affected. Last, this study identified potential military and Veteran Health Administration intervention sites. All analyses were conducted in 2015. Within the National Violent Death Reporting System participating states, an estimated 262 (33%) current military suicides occurred in just ten (1.0%) counties, and 391 (33%) Veteran suicides occurred in 33 (3.4%) counties. Mental health and intimate partner problems were common precipitating circumstances, and some circumstances differed between cases in high- versus those in medium/low-density counties. Multiple potential intervention sites were identified in high-density counties. These findings suggest that military and Veteran suicides are concentrated in a small number of counties. Increased efforts at these locales might be beneficial. Published by Elsevier Inc.

78 FR 41390 - Pershing County Water Conservation District; Notice of Application Tendered for Filing with the...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-10

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 14327-000] Pershing County Water Conservation District; Notice of Application Tendered for Filing with the Commission and Soliciting Additional Study Requests Take notice that the following hydroelectric application has been filed with the Commission and is available for...

Exposure to TCDD from base perimeter application of Agent Orange in Vietnam.

PubMed

Ross, John H; Hewitt, Andrew; Armitage, James; Solomon, Keith; Watkins, Deborah K; Ginevan, Michael E

2015-04-01

Using recognized methods routinely employed by pesticide regulatory agencies, the exposures of military personnel that were mixer/loader/applicators (M/L/A) of Agent Orange (AO) for perimeter foliage at bases during the Vietnam War were estimated. From the fraction of TCDD in AO, absorbed dosage of the manufacturing contaminant was estimated. Dermal exposure estimated from spray drift to residents of the bases was calculated using internationally recognized software that accounted for proximity, foliar density of application site, droplet size and wind speed among other factors, and produced estimates of deposition. Those that directly handled AO generally had much higher exposures than those further from the areas of use. The differences in exposure potential varied by M/L/A activity, but were typically orders of magnitude greater than bystanders. However, even the most-exposed M/L/A involved in perimeter application had lifetime exposures comparable to persons living in the U.S. at the time, i.e., ~1.3 to 5 pg TCDD/kg bodyweight. Copyright © 2014 Elsevier B.V. All rights reserved.

Decreasing institutionally imposed regulatory burden for animal research.

PubMed

Pritt, Stacy; McNulty, Justin A; Greene, Molly; Light, Sally; Brown, Marcy

2016-07-20

With the ever-increasing call to reduce self-imposed regulatory and administrative burden in the animal research oversight process, knowledge of the regulations and a desire to streamline policies and procedures are needed to affect a change in culture. In this opinion piece, we provide details on why institutionally imposed regulatory burden can arise.

Carotenoid accumulation in orange-pigmented Capsicum annuum fruit, regulated at multiple levels.

PubMed

Rodriguez-Uribe, Laura; Guzman, Ivette; Rajapakse, Wathsala; Richins, Richard D; O'Connell, Mary A

2012-01-01

The pericarp of Capsicum fruit is a rich dietary source of carotenoids. Accumulation of these compounds may be controlled, in part, by gene transcription of biosynthetic enzymes. The carotenoid composition in a number of orange-coloured C. annuum cultivars was determined using HPLC and compared with transcript abundances for four carotenogenic enzymes, Psy, LcyB, CrtZ-2, and Ccs determined by qRT-PCR. There were unique carotenoid profiles as well as distinct patterns of transcription of carotenogenic enzymes within the seven orange-coloured cultivars. In one cultivar, 'Fogo', carrying the mutant ccs-3 allele, transcripts were detected for this gene, but no CCS protein accumulated. The premature stop termination in ccs-3 prevented expression of the biosynthetic activity to synthesize the capsanthin and capsorubin forms of carotenoids. In two other orange-coloured cultivars, 'Orange Grande' and 'Oriole', both with wild-type versions of all four carotenogenic enzymes, no transcripts for Ccs were detected and no red pigments accumulated. Finally, in a third case, the orange-coloured cultivar, Canary, transcripts for all four of the wild-type carotenogenic enzymes were readily detected yet no CCS protein appeared to accumulate and no red carotenoids were synthesized. In the past, mutations in Psy and Ccs have been identified as the loci controlling colour in the fruit. Now there is evidence that a non-structural gene may control colour development in Capsicum.

75 FR 63533 - Environmental Impact Statement: Cameron County, TX

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-15

...: Cameron County, TX AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Rescind Notice of Intent..., 300 East 8th Street, Room 826, Austin, Texas 78701, Telephone (512) 536-5960. SUPPLEMENTARY INFORMATION: On April 6, 2007, TxDOT and FHWA announced their revised Notice of Intent to prepare an EIS...

75 FR 62627 - Environmental Impact Statement; Davis County, UT

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-12

... County, UT AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of Intent. SUMMARY: FWHA is... cooperation with the Utah Department of Transportation (UDOT), will prepare an EIS on a proposal to address... and need and are based on agency and public input. These alternatives include: (1) Taking no action...

Effect of sweet orange aroma on experimental anxiety in humans.

PubMed

Goes, Tiago Costa; Antunes, Fabrício Dias; Alves, Péricles Barreto; Teixeira-Silva, Flavia

2012-08-01

The objective of this study was to evaluate the potential anxiolytic effect of sweet orange (Citrus sinensis) aroma in healthy volunteers submitted to an anxiogenic situation. Forty (40) male volunteers were allocated to five different groups for the inhalation of sweet orange essential oil (test aroma: 2.5, 5, or 10 drops), tea tree essential oil (control aroma: 2.5 drops), or water (nonaromatic control: 2.5 drops). Immediately after inhalation, each volunteer was submitted to a model of anxiety, the video-monitored version of the Stroop Color-Word Test (SCWT). Psychologic parameters (state-anxiety, subjective tension, tranquilization, and sedation) and physiologic parameters (heart rate and gastrocnemius electromyogram) were evaluated before the inhalation period and before, during, and after the SCWT. Unlike the control groups, the individuals exposed to the test aroma (2.5 and 10 drops) presented a lack of significant alterations (p>0.05) in state-anxiety, subjective tension and tranquillity levels throughout the anxiogenic situation, revealing an anxiolytic activity of sweet orange essential oil. Physiologic alterations along the test were not prevented in any treatment group, as has previously been observed for diazepam. Although more studies are needed to find out the clinical relevance of aromatherapy for anxiety disorders, the present results indicate an acute anxiolytic activity of sweet orange aroma, giving some scientific support to its use as a tranquilizer by aromatherapists.

Generalized potentiometric surface of the Arikaree aquifer, Pine Ridge Indian Reservation and Bennett County, South Dakota

USGS Publications Warehouse

Carter, Janet M.; Heakin, Allen J.

2007-01-01

INTRODUCTION The Pine Ridge Indian Reservation and Bennett County are located in southwest South Dakota. The Pine Ridge Indian Reservation includes all of Shannon County and the part of Jackson County south of the White River. Extensive Indian trust lands are in Bennett County. For purposes of this map, the Pine Ridge Indian Reservation and all of Bennett County are included in the study area (sheet 1). Ground water from wells and springs is the predominant source of public and domestic supply within the study area. The Arikaree aquifer is the largest source of ground water throughout this area. The Oglala Sioux Tribe is developing a ground-water management plan designed to “preserve, protect and maintain the quality of ground water for living and future members and non-members of the Oglala Sioux Indian Tribe within the internal and external boundaries of the Pine Ridge Reservation” (Michael Catches Enemy, Oglala Sioux Tribe Natural Resources Regulatory Agency, oral commun., 2007). Hydrologic information about the Arikaree aquifer is important to managing this resource. In 1998, the U.S. Geological Survey (USGS) began working in cooperation with the Oglala Sioux Tribe to develop a potentiometric map of the Arikaree aquifer in Jackson and Shannon Counties, with a primary component of that effort being a well inventory in those counties. In 2003, the study area was expanded to include Bennett County.

A role for the deep orange and carnation eye color genes in lysosomal delivery in Drosophila.

PubMed

Sevrioukov, E A; He, J P; Moghrabi, N; Sunio, A; Krämer, H

1999-10-01

Deep orange and carnation are two of the classic eye color genes in Drosophila. Here, we demonstrate that Deep orange is part of a protein complex that localizes to endosomal compartments. A second component of this complex is Carnation, a homolog of Sec1p-like regulators of membrane fusion. Because complete loss of deep orange function is lethal, the role of this complex in intracellular trafficking was analyzed in deep orange mutant clones. Retinal cells devoid of deep orange function completely lacked pigmentation and exhibited exaggerated multivesicular structures. Furthermore, a defect in endocytic trafficking was visualized in developing photoreceptor cells. These results provide direct evidence that eye color mutations of the granule group also disrupt vesicular trafficking to lysosomes.

Influence of the protonation state on the binding mode of methyl orange with cucurbiturils

NASA Astrophysics Data System (ADS)

He, Suhang; Sun, Xuzhuo; Zhang, Haibo

2016-03-01

Binding modes of methyl orange (MO) with cucurbiturils (CBs) have been investigated by Single Crystal X-ray Diffraction and NMR Spectroscopy. Detailed study of intermolecular interactions was supported by the Hirshfeld surface analysis. Protonation state of the anionic part of methyl orange has greatly influenced the binding mode of the complex. Stabilized by hydrogen bonding at the portal, hydrophobic and dispersion interactions in the cavity, the protonated methyl orange was deeply inserted into the cavity. On the contrary, the anionic methyl orange has been pushed towards the outside of the cavity by the electrostatic repulsion between the azo group and the portal oxygen. A ;water bridge; was found in MO@CB8 linking both host and guest via hydrogen bonds.

Trapping characteristic of halloysite lumen for methyl orange

NASA Astrophysics Data System (ADS)

Chen, Hao; Yan, Hua; Pei, Zhenzhao; Wu, Junyong; Li, Rongrong; Jin, Yanxian; Zhao, Jie

2015-08-01

The interaction of clay minerals and dyes is an area of great interest especially in the development of novel adsorbents. In this report, we demonstrated interaction of halloysite nanotubes (HNTs) and an anionic dye, methyl orange (MO), through a electrostatic attraction. Halloysite lumen has a trapping characteristic for methyl orange, which is mainly determined by the positively charged nature of the inner surface of HNTs. XRD results confirmed that intercalation of methyl orange into HNTs did not occur. SEM-EDS and photostability results showed that MO molecules were primarily in HNTs lumen. Adsorption isotherm studies revealed an interesting phenomenon, i.e., a sudden increase of adsorption capacity occurred in the initial dye concentration of about 75 mg/L, which was just the dye concentration corresponding to the onset of dye oligomer formation. This suggested dye aggregation state had a decisive influence to the adsorption behavior of MO on the halloysite. BET results demonstrated at low and high dye concentrations, single MO molecule and aggregation of several dimers through hydrophobic interaction, interacted with Al-OH2+ sites on the inner wall, respectively. Desorption experiments showed that MO in HNTs can be completely removed with deionized water, indicating halloysite is a low-cost and efficient adsorbent for anionic dye.

A Merger Feasibility Study: Greenville City and Pitt County (North Carolina) Schools. Final Report, 22N-2572.

ERIC Educational Resources Information Center

Pyecha, John N.; And Others

This report contains findings and recommendations based on a study conducted to determine the feasibility of merging the Pitt County and Greenville County (North Carolina) school systems. Each school system is described in terms of pupil population patterns, building use, and educational and administrative services; issues related to these…

Management of invading pathogens should be informed by epidemiology rather than administrative boundaries.

PubMed

Thompson, Robin N; Cobb, Richard C; Gilligan, Christopher A; Cunniffe, Nik J

2016-03-24

Plant and animal disease outbreaks have significant ecological and economic impacts. The spatial extent of control is often informed solely by administrative geography - for example, quarantine of an entire county or state once an invading disease is detected - with little regard for pathogen epidemiology. We present a stochastic model for the spread of a plant pathogen that couples spread in the natural environment and transmission via the nursery trade, and use it to illustrate that control deployed according to administrative boundaries is almost always sub-optimal. We use sudden oak death (caused by Phytophthora ramorum ) in mixed forests in California as motivation for our study, since the decision as to whether or not to deploy plant trade quarantine is currently undertaken on a county-by-county basis for that system. However, our key conclusion is applicable more generally: basing management of any disease entirely upon administrative borders does not balance the cost of control with the possible economic and ecological costs of further spread in the optimal fashion.