Science.gov

Sample records for adulto um conceito

  1. Sky Observation with the Use of the Software Stellarium for Teaching Astronomy in Classes of Youth and Adult Education. (Spanish Title: Observación del Cielo con la Utilización del Software Stellarium en Las Clases de Educación de Jóvenes y Adultos.) Observação do Céu Aliada À Utilização do Software Stellarium no Ensino de Astronomia em Turmas de Educação de Jovens e Adultos (EJA)

    NASA Astrophysics Data System (ADS)

    Oliveira Bernardes, Adriana

    2010-12-01

    en las ciencias, o sea, elaborar y desarrollar un plan de alfabetización científica. Se describe en detalle este plan, las actividades realizadas y los resultados obtenidos hasta el presente. O objetivo do presente artigo é apresentar um projeto desenvolvido através de parceria entre o Clube de Astronomia de Itaocara Marcos Pontes (CAIMP) e o Colégio Estadual Jaime Queiroz de Souza, ambos localizados na cidade de Itaocara, no Noroeste Fluminense, no sentido de divulgar junto às turmas de EJA (Ensino de Jovens e Adultos) a disciplina Astronomia. Conhecendo o caráter interdisciplinar da Astronomia, desenvolvemos este trabalho para motivar o aprendizado de Ciências junto a alunos de EJA do Ensino Médio que cursam as disciplinas Química, Física e Biologia. Inicialmente, realizamos na escola pesquisa sobre o conhecimento prévio de Astronomia da turma de EJA, observando que é escasso o conhecimento de conceitos básicos do tema, muitos dos quais deveriam ser assimilados através do conteúdo da disciplina Física. Com esses dados, foi possível elaborar várias atividades que possibilitassem um maior envolvimento dos estudantes com a Ciência, realizando dentro da escola um trabalho de alfabetização científica, cujas atividades serão apresentadas neste artigo.

  2. Educacao Fisica Escolar: A Construcao de um Conceito (School Physical Education: The Construction of a Concept).

    ERIC Educational Resources Information Center

    Colpas, Ricardo Ducatti

    2000-01-01

    Seeks to understand school physical education praxis in light of the human development theories of Lev Vygotsky. Develops a methodology of teaching and a conception of learning that enables students to recognize physical education as a school discipline connected to a dynamic curriculum. (BT)

  3. Análise dos Conceitos Astronômicos Apresentados por Professores de Algumas Escolas Estaduais Brasileiras

    NASA Astrophysics Data System (ADS)

    Voelzke, Marcos Rincon; Gonzaga, Edson Pereira

    2011-12-01

    A razão para o desenvolvimento deste trabalho baseia-se no fato de que muitos professores da Educação Básica (EB) não lidam com conceitos relacionados à astronomia, e quando o fazem eles simplesmente seguem livros didáticos que podem conter erros conceituais. Como é de conhecimento geral a astronomia é um dos conteúdos a serem ensinados na EB fazendo parte dos Parâmetros Curriculares Nacionais e das Propostas Curriculares do Estado de São Paulo, mas é um fato, que vários pesquisadores apontam, a existência de muitos problemas no ensino da astronomia. Com o propósito de minimizar algumas dessas deficiências foi realizado um trabalho de pesquisa com a utilização de questionários pré e pós pesquisa, para tanto foi desenvolvido um Curso de Extensão Universitária para professores da Diretoria de Ensino Regional (DE) que abrange Mauá, Ribeirão Pires e Rio Grande da Serra (no Estado de São Paulo) com os seguintes objetivos: levantar concepções alternativas; subsidiar os professores por meio de palestras, debates e workshops, e verificar o sucesso da aprendizagem após o curso, adotando-se como referência, para a análise dos resultados, os dicionários de Língua Portuguesa (FERREIRA, 2004) e Enciclopédico de Astronomia e Astronáutica (MOURĀO, 1995). Portanto, dezesseis questões foram aplicadas antes e após o curso, assim pode-se verificar após a pesquisa que 100,0% dos professores sabiam os nomes das fases da Lua, 97,0% entenderam que o Sistema Solar é composto por oito planetas, 78,1% foram capazes de explicar como ocorre um eclipse lunar, um eclipse solar e um solstício, 72,7% sabiam como explicar a ocorrência das estações do ano; 64,5% explicaram corretamente a ocorrência do equinócio, 89,7% foram capazes de definir adequadamente o termo cometa; 63,6% definiram asteróide, 54,5% meteoro, 58,1% galáxia, e 42,4% planeta. Os resultados obtidos indicam uma aprendizagem significativa por parte dos participantes.

  4. Revista Interamericana de Educacion de Adultos, 2003 (Interamerican Review of Adult Education, 2003).

    ERIC Educational Resources Information Center

    Guerra, Alfonso Rangel, Ed.

    2003-01-01

    This journal offers a collection of Spanish-language articles, including: "Educacion a Distancia y Uso de las Tecnologias: Experiencias Desafios y Oportunidades Educativas para Jovenes y Adultos" (Ma. Mercedes Ruiz); "Volver a a Educacion Fundamental? Notas para una Arquelogia de los Mandatos Fundacionales del CREFAL" (Jorge Rivas Diaz); "Una…

  5. Revista Interamericana de Educacion de Adultos, 1999 (Interamerican Review of Adult Education, 1999).

    ERIC Educational Resources Information Center

    Soberanes, Juan F. Millan, Ed.

    1999-01-01

    This journal, written in Spanish, is a publication of the Centro de Cooperacion Regional para la Educacion de Adultos en America Latina y el Caribe (CREFAL), published in conjunction with the OAS. Its main objective is the dissemination of information on research and theoretical and methodological innovation in the field of adult education.…

  6. RELACIÓN MÉDICO PACIENTE: DERECHOS DEL ADULTO MAYOR

    PubMed Central

    Barrantes-Monge, Melba; Rodríguez, Eduardo; Lama, Alexis

    2009-01-01

    Existen prejuicios en relación con la vejez, incluso entre los profesionales que se dedican a la gerontología. Uno común y peligroso es considerar que los viejos son todos enfermos o discapacitados. La relación médico-paciente es la piedra angular de la práctica y ética médicas. Para alcanzar el respeto por los adultos mayores es necesaria una medicina prudente, basada en una práctica en la cual la reflexión ética y clínica pueda contribuir. Esto último es posible si se hacen valer los derechos del adulto mayor, en particular como paciente para la toma de decisiones. PMID:20379380

  7. Basic Concepts of Astronomy: a Methodological Proposal. (Spanish Title: Conceptos Básicos de Astronomía: Una Propuesta Metodológica.) Conceitos Básicos de Astronomia: Uma Proposta Metodológica

    NASA Astrophysics Data System (ADS)

    Darroz, Luiz Marcelo; Heineck, Renato; Samudio Pérez, Carlos Ariel

    2011-12-01

    obtenidos en diferentes momentos, por los comentarios efectuados por los participantes durante las actividades y por los altos índices de aprobación al final de la etapa, consideramos que la propuesta atingió los objetivos establecidos y puede ser repetida con certeza de éxito. Neste relato, descreve-se o desenvolvimento de uma proposta metodológica que aborda conceitos básicos de astronomia fundamentada pedagogicamente na Aprendizagem Significativa. A proposta, que compreende quatro encontros, foi desenvolvida por professores e acadêmicos do curso de Licenciatura em Física da Universidade de Passo Fundo (UPF), através de um curso de extensão, a um grupo de dez estudantes do ensino médio de uma escola pública da cidade de Passo Fundo, RS. O trabalho centrou-se em conceitos básicos de astronomia. Os indícios da aprendizagem significativa foram obtidos por instrumentos de pesquisa e avaliação aplicados ao término de cada encontro. A avaliação da proposta foi efetuada através de um questionário final respondido pelos participantes ao término do desenvolvimento das atividades. Pelos resultados obtidos nos diferentes instrumentos, pelos comentários efetuados pelos participantes durante as atividades e pelos altos índices de aprovação alcançados no questionário final, consideramos que a proposta atingiu os objetivos estabelecidos e pode ser repetida com convicção de sucesso.

  8. Salud mental en desastres naturales: estrategias interventivas con adultos mayores en sectores rurales de Chile.

    PubMed

    Osorio-Parraguez, Paulina; Espinoza, Adriana

    2016-06-01

    En el presente artículo se da a conocer una estrategia de intervención llevada a cabo con adultos mayores en la comuna de Paredones, sexta región de Chile, con posterioridad al terremoto y tsunami del 27 de febrero 2010 en Chile, en el contexto de una investigación sobre fortalezas y vulnerabilidades desplegadas por este grupo etario, con posterioridad a un desastre natural. Se presenta una descripción del desarrollo metodológico de la intervención y de los sustentos teóricos y conceptuales en los que se basa. Como resultado de este proceso, se propone una estrategia que trabaje a través de la identificación de las propias experiencias y fortalezas de los sujetos. De tal forma se minimizan los efectos negativos de los determinantes sociales de la salud (como la edad y el lugar de residencia) en contexto de crisis; permitiendo a los adultos mayores fortalecer sus recursos individuales y colectivos, en pro de su bienestar psicosocial. PMID:25724751

  9. Um Infixation and Prefixation in Toba Batak.

    ERIC Educational Resources Information Center

    Crowhurst, Megan J.

    1998-01-01

    Examines the behavior of the morpheme, um, in Toba Batak and Tagalog, which alternates as a prefix or an infix, arguing that the variation is conditioned by constraints on consonant clusters. Three patterns of variation that occur with um are described, noting that the stages involved in changing from infixed to prefixed positions over time are…

  10. Factor Analysis of the Spanish Version of the WAIS: The Escala de Inteligencia Wechsler para Adultos (EIWA).

    ERIC Educational Resources Information Center

    Gomez, Francisco C., Jr.; And Others

    1992-01-01

    The standardization of the Escala de Inteligencia Wechsler para Adultos (EIWA) and the original Wechsler Adult Intelligence Scale (WAIS) were subjected to principal components analysis to examine their comparability for 616 EIWA subjects and 800 WAIS subjects. Similarity of factor structures of both scales is supported. (SLD)

  11. Lecturas sobre educacion de adultos en America latina (Readings on Adult Education in Latin America). Serie: Retablo de Papel 14.

    ERIC Educational Resources Information Center

    Latapi, Pablo, Comp.; Castillo, Alfonso, Comp.

    Twelve essays written in Spanish on the state of adult education in Latin America are presented. The essays are organized into three main sections, including: "Concepto y evolucion historica de la educacion de adultos" (Conception and Historical Evolution of Adult Education); "Aspectos particulares" (Specific Subjects); and "Tendencias y…

  12. Muchos adolescentes y adultos jóvenes supervivientes de cáncer tienen problemas crónicos de salud

    Cancer.gov

    Artículo sobre los resultados de un estudio realizado en 2012 que subrayan la importancia de abordar las necesidades especiales e inquietudes de los adolescentes y adultos jóvenes supervivientes de cáncer.

  13. Uma Visão do Universo Segundo um Grupo de Alunos do Ensino Médio de São Paulo

    NASA Astrophysics Data System (ADS)

    Elias, D. S.; Araújo, M.; Amaral, L. H.; Voelzke, M. R.; Araújo, M.

    2005-08-01

    A astronomia, embora seja uma ciência popular, com inúmeras descobertas de interesse público, ainda é apresentada desconsiderando-se os aspectos históricos e científicos relacionados ao seu desenvolvimento, sendo geralmente veiculada nos meios de comunicação de maneira pouco esclarecedora e não raro com imprecisões. Neste trabalho analisou-se a concepção de um grupo de estudantes de Ensino Médio sobre conceitos de astronomia, visando identificar sua visão de mundo a respeito do Universo, envolvendo idéias sobre espaço e tempo. Para issso, foi aplicado um questionário em três escolas da grande São Paulo em um espaço amostral de 270 alunos. Constatou-se que, embora o ensino de astronomia esteja previsto nos PCNEM, os resultados obtidos na pesquisa mostram que há grande deficiência no conhecimento dos temas investigados. Nesse sentido, verificou-se que apenas 20% dos alunos eram capazes de relacionar a sucessão das semanas com as fases da lua, enquanto 28% associaram as estações do ano à inclinação do eixo de rotação da Terra. Por outro lado, somente 23% dos alunos tinham noções das distâncias entre os objetos celestes próximos da Terra e 56% conseguiram relacionar o Big Bang com a origem do Universo. Finalmente, constatou-se que 37% reconheciam o ano-luz como uma unidade de distância e 60% reconheciam o Sol como sendo uma estrela. Apesar de 60% dos alunos indicarem que a escola é a principal fonte para aquisição dos conhecimentos de astronomia, conclui-se que seus conceitos nessa área ainda são inadequados, havendo necessidade de ampliação e aprimoramento da abordagem desses conteúdos nos ambientes escolares.

  14. Añadir quimioterapia después de la radioterapia mejora la supervivencia de adultos con un tipo de tu

    Cancer.gov

    Adultos con gliomas de grado bajo, una forma de tumor cerebral, que recibieron tratamiento con quimioterapia después de la radioterapia vivieron más tiempo que pacientes que recibieron solo radioterapia, según los resultados de seguimiento a largo plazo d

  15. Comparison of Scores on the WAIS and Its Puerto Rican Counterpart, Escala de Inteligencia Wechsler para Adultos, in an Institutionalized Latin American Psychiatric Population.

    ERIC Educational Resources Information Center

    Davis, Todd McLin; Rodriguez, Vene L.

    1979-01-01

    Compared vocabulary and block design subtests of the Wechsler Adult Intelligence Scale (WAIS) and its Puerto Rican counterpart, the Escala de Inteligencia Wechsler para Adultos (EIWA), in hospitalized Latins and Trans-Caribbean Blacks. EIWA scores were significantly higher than WAIS scores. Equivalence of EIWA and WAIS estimates is questioned.…

  16. Parylene supported 20um*20um uncooled thermoelectric infrared detector with high fill factor

    NASA Astrophysics Data System (ADS)

    Modarres-Zadeh, Mohammad J.; Carpenter, Zachary S.; Rockley, Mark G.; Abdolvand, Reza

    2012-06-01

    Presented is a novel design for an uncooled surface-micromachined thermoelectric (TE) infrared (IR) detector. The detector features a P-doped polysilicon/Nichrome (Cr20-Ni80) thermocouple, which is embedded into a thin layer of Parylene-N to provide structural support. The low thermal conductivity (~0.1W/m.K), chemical resistance, and ease of deposition/patterning of Parylene-N make it an excellent choice of material for use in MEMS thermal detectors. This detector also features an umbrella-like IR absorber composed of a three layer stack of NiCr/SiN/NiCr to optimize IR absorption. The total device area is 20 um * 20 um per pixel with an absorber area of ~19 um * 19 um resulting in a fill factor of 90%. At room temperature, a DC responsivity of ~170V/W with a rise time of less than 8 ms is measured from the fabricated devices in vacuum when viewing a 500K blackbody without any concentrating optics. The dominant source of noise in thermoelectric IR detectors is typically Johnson noise when the detectors are operating in an open circuit condition. The fabricated detectors have resistances about 85KOhm which results in Johnson noise of about 38nV/Hz^0.5. The D* is calculated to be 9 * 106 cm*Hz0.5/ W. Preliminary finite element analysis indicates that the thermal conduction from the hot junction to the substrate through the TE wires is dominant ( GTE >> Gparylene) considering the fabricated dimensions of the parylene film and the TE wires. Thus, by further reducing the size of the TE wires, GTE can be decreased and hence, responsivity can be improved while the parylene film sustains the structural integrity of the cell.

  17. "Uh" and "Um" Revisited: Are They Interjections for Signaling Delay?

    ERIC Educational Resources Information Center

    O'Connell, Daniel C.; Kowal, Sabine

    2005-01-01

    Clark and Fox Tree (2002) have presented empirical evidence, based primarily on the London-Lund corpus (LL; Svartvik & Quirk, 1980), that the fillers "uh" and "um" are conventional English words that signal a speaker's intention to initiate a minor and a major delay, respectively. We present here empirical analyses of "uh" and "um" and of silent…

  18. Evolution of the Astronomy Concepts Along Basic Education Cycle. (Breton Title: Evolução dos Conceitos de Astronomia no Decorrer da Educação Básica.) La Evolución de los Conceptos de Astronomía Durante la Educación Básica

    NASA Astrophysics Data System (ADS)

    Darroz, Luiz Marcelo; da Rosa, Cleci Werner; Becker da Rosa, Álvaro; Samudio Pèrez, Carlos Ariel

    2014-07-01

    learning of astronomy in basic education. Embora a astronomia seja considerada uma das ciências mais antigas da humanidade e ainda que a compreensão de seus conceitos tenha trazido enormes avanços para a Ciência e, consequentemente, para a sociedade, observa-se que uma parcela significativa de pessoas encontra-se à margem desses conhecimentos. De acordo com os Parâmetros Curriculares Nacionais para a Educação Básica, cabe à escola a difusão dos conceitos cientificamente corretos, entre eles os relacionados à área de astronomia. Pertinente a essa questão, apresenta-se uma pesquisa realizada com 140 estudantes do nono ano do ensino fundamental e com 120 estudantes da terceira série do ensino médio de quatro escolas da região de Passo Fundo/RS. Buscou-se averiguar, por meio de um questionário composto de questões abertas e de múltipla escolha, o conhecimento desse grupo de estudantes acerca de termos e fenômenos astronômicos básicos e, também, verificar se o índice de acertos cresce à medida que eles avançam nas diferentes e gradativas séries dos ensinos fundamental e médio. De modo geral, os resultados apresentados demonstram que o ensino de astronomia na educação básica enfrenta deficiências. Das 20 questões investigadas, em 17 os índices de acertos são semelhantes nas respostas dadas por estudantes de nível fundamental e médio, revelando que muitas concepções equivocadas permanecem ao longo da educação básica. Isso evidencia que tais temas não são - ou são pouco - abordados durante esses dois níveis de escolarização. Assim, conclui-se que a discussão dos conceitos relacionados com a astronomia deve receber maior ênfase na abordagem dos diferentes conteúdos, sendo necessária uma ação nacional em prol do seu ensino. Acredita-se que essa ação nacional deve estar apoiada em um pilar triplo de atores coletivos: comunidade científica, comunidade astronômica semiprofissional e comunidade escolar. Por fim, esse pilar seria

  19. Ultra-high resolution polarization-sensitive optical coherence microscopy for brain imaging at 6 um, 3.4 um and 1.3 um resolution (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Wang, Hui; Akkin, Taner; Magnain, Caroline V.; Yaseen, Mohammad A.; Cramer, Avilash; Wang, Ruopeng; Sakadžic, Sava; Boas, David A.

    2016-03-01

    Neuroanatomical pathways form the basis for functional activity of brain circuits. In the past, we developed a polarization-sensitive optical coherence tomography with serial scanning to achieve large-scale brain imaging. The system was able to visualize 3D fiber tracts of ~20 um in diameter. To investigate the neuroanatomical pathways at finer scales, we have now built a polarization-maintaining fiber based ultra-high resolution polarization-sensitive optical coherence microscope (PS-OCM) at 1300 nm. The PS-OCM has an axial resolution of 3.5 um in tissue. The detection setup consists of two spectrometers, acquiring spectral interference on orthogonal polarization channels. With a single measurement, the setup generates four contrasts: reflectivity, cross-polarization, retardance and optic axis orientation. To investigate the capability of PS-OCM at different resolutions, we used three microscope objectives that yield lateral resolutions of 6.0 um, 3.4 um and 1.3 um. Blocks of formalin fixed mouse brain and human brain were scanned. The cross-polarization and retardance images clearly depict the neuronal fiber structures, which are comparable with that generated by the maximum projection of volumetric reflectivity data. The optic axis orientation quantifies the in-plane fiber orientation. With the lateral resolution of 1.3 um, the retardance contrast is weak in white matter due to the shallow depth of focus. Overall, the ultra-high resolution PS-OCM provides a new tool to reveal neuroanatomical maps in the brain at cellular resolution.

  20. Uh and um revisited: are they interjections for signaling delay?

    PubMed

    O'Connell, Daniel C; Kowal, Sabine

    2005-11-01

    Clark and Fox Tree (2002) have presented empirical evidence, based primarily on the London-Lund corpus (LL; Svartvik & Quirk, 1980), that the fillers uh and um are conventional English words that signal a speaker's intention to initiate a minor and a major delay, respectively. We present here empirical analyses of uh and um and of silent pauses (delays) immediately following them in six media interviews of Hillary Clinton. Our evidence indicates that uh and um cannot serve as signals of upcoming delay, let alone signal it differentially: In most cases, both uh and um were not followed by a silent pause, that is, there was no delay at all; the silent pauses that did occur after um were too short to be counted as major delays; finally, the distributions of durations of silent pauses after uh and um were almost entirely overlapping and could therefore not have served as reliable predictors for a listener. The discrepancies between Clark and Fox Tree's findings and ours are largely a consequence of the fact that their LL analyses reflect the perceptions of professional coders, whereas our data were analyzed by means of acoustic measurements with the PRAAT software (www.praat.org). A comparison of our findings with those of O'Connell, Kowal, and Ageneau (2005) did not corroborate the hypothesis of Clark and Fox Tree that uh and um are interjections: Fillers occurred typically in initial, interjections in medial positions; fillers did not constitute an integral turn by themselves, whereas interjections did; fillers never initiated cited speech, whereas interjections did; and fillers did not signal emotion, whereas interjections did. Clark and Fox Tree's analyses were embedded within a theory of ideal delivery that we find inappropriate for the explication of these phenomena. PMID:16341914

  1. Análise sobre o Conhecimento de um Grupo de Alunos do Ensino Médio da Rede Estadual de São Paulo sobre Termos e Fenômenos Astronômicos do Cotidiano

    NASA Astrophysics Data System (ADS)

    de Oliveira, E. F.; Voelzke, M. R.; Amaral, L. H.

    2007-08-01

    Embora os Parâmetros Curriculares Nacionais do Ensino Médio (PCN-EM) e as orientações complementares a esses Parâmetros (PCN+) apontem a importância de uma abordagem significativa de conceitos relacionados à astronomia nas aulas de Física, muitos estudantes terminam o Ensino Médio (EM) sem compreender a razão de certos acontecimentos de origem celeste, ainda que estes façam parte de seu cotidiano. Este trabalho tem por objetivo analisar os conhecimentos básicos em astronomia dos alunos de EM da escola estadual Batista Renzi, bem como investigar os meios através dos quais estes conhecimentos foram adquiridos. Para tanto foi elaborado um questionário de múltipla escolha aplicado a 310 alunos distribuídos entre as três séries do EM dos períodos matutino e noturno. Dessa forma, observou-se que apenas 34,5% relacionaram as estações do ano à inclinação do eixo de rotação da Terra, 21,3% indicaram a influência gravitacional da Lua e do Sol como responsáveis pelo fenômeno das marés, 24,5% indicaram corretamente quais são os objetos celestes mais próximos da Terra, 36,1% identificaram ano-luz como uma medida de distância e 34,2% reconheceram uma estrela cadente como meteoro. Em contrapartida, 67,1% compreendiam a sucessão entre dia e noite, 73,9% identificaram o Sol como estrela e 52,3% relacionaram o Big Bang à origem do Universo. Além disso, foram comparadas as respostas de alunos de diferentes séries e períodos, observando-se, dentre outras coisas, que os estudantes do terceiro ano apresentam um percentual de acertos semelhante ao dos alunos do primeiro, caracterizando que a abordagem de tópicos relacionados à astronomia no EM não tem contribuído para uma maior compreensão dos fenômenos e conceitos.

  2. A Reappraising of Cosmography: the Interface Between Astronomical and Geographic Studies. (Breton Title: Releitura do Conceito de Cosmografia: a Interface Entre os Estudos Astronômicos e Geográficos.) Una Relectura del Concepto de Cosmografía: la Interfase Entre los Estudios Astronómicos y Geográficos

    NASA Astrophysics Data System (ADS)

    Azevedo Sobreira, Paulo Henrique

    2012-12-01

    The concept of "Cosmography" is in disuse since the 80s of the last century, but the astronomical themes previously discussed in the school subjects of Geography and Cosmography remain in current textbooks. The use of term "Cosmography" was rescued in this research, and the study of its re-signification prompted the appearance of the term Geographic Cosmography. The Geographic Cosmography is a field of studies of the Geography, whose set of knowledge and skills is predominantly scholar. It studies the interface between terrestrial and celestial knowledge, and assigns a geographic significance to them. It examines human and natural relationships with Sidereal Space and its consequences for society and nature. O conceito de "Cosmografia" está em desuso desde os anos 80 do século XX, mas os temas astronômicos anteriormente abordados nas disciplinas escolares de Cosmografia e de Geografia permanecem nos atuais livros didáticos. O uso do termo "Cosmografia" foi resgatado nesta pesquisa e o estudo de sua ressignificação proporcionou o surgimento do termo Cosmografia Geográfica. A Cosmografia Geográfica é um campo de estudos da Geografia, cujo conjunto de conhecimentos e habilidades é predominantemente escolar. Estuda a interface entre os conhecimentos terrestres e os celestes e lhes atribui significância geográfica. Analisa as relações humanas e naturais com o Espaço Sideral e suas consequências para a sociedade e a natureza.

    Aunque el concepto de "Cosmografía" no se usa desde la década de los '80 del siglo pasado, los temas astronómicos que se enseñaban anteriormente en las asignaturas escolares de Cosmografía y de Geografía permanecen en los actuales libros didácticos. El uso del término "Cosmografía" fue rescatado en esta investigación y el estudio de su resignificación proporcionó el surgimiento del término Cosmografía Geográfica. La Cosmografía Geográfica es un campo de estudio de la Geografía, donde

  3. QuorUM: An Error Corrector for Illumina Reads

    PubMed Central

    Marçais, Guillaume; Yorke, James A.; Zimin, Aleksey

    2015-01-01

    Motivation Illumina Sequencing data can provide high coverage of a genome by relatively short (most often 100 bp to 150 bp) reads at a low cost. Even with low (advertised 1%) error rate, 100 × coverage Illumina data on average has an error in some read at every base in the genome. These errors make handling the data more complicated because they result in a large number of low-count erroneous k-mers in the reads. However, there is enough information in the reads to correct most of the sequencing errors, thus making subsequent use of the data (e.g. for mapping or assembly) easier. Here we use the term “error correction” to denote the reduction in errors due to both changes in individual bases and trimming of unusable sequence. We developed an error correction software called QuorUM. QuorUM is mainly aimed at error correcting Illumina reads for subsequent assembly. It is designed around the novel idea of minimizing the number of distinct erroneous k-mers in the output reads and preserving the most true k-mers, and we introduce a composite statistic π that measures how successful we are at achieving this dual goal. We evaluate the performance of QuorUM by correcting actual Illumina reads from genomes for which a reference assembly is available. Results We produce trimmed and error-corrected reads that result in assemblies with longer contigs and fewer errors. We compared QuorUM against several published error correctors and found that it is the best performer in most metrics we use. QuorUM is efficiently implemented making use of current multi-core computing architectures and it is suitable for large data sets (1 billion bases checked and corrected per day per core). We also demonstrate that a third-party assembler (SOAPdenovo) benefits significantly from using QuorUM error-corrected reads. QuorUM error corrected reads result in a factor of 1.1 to 4 improvement in N50 contig size compared to using the original reads with SOAPdenovo for the data sets investigated

  4. The International Space Station Urine Monitoring System (UMS)

    NASA Technical Reports Server (NTRS)

    Feeback, Daniel L.; Cibuzar, Branelle R.; Milstead, Jeffery R.; Pietrzyk,, Robert A.; Clark, Mark S.F.

    2009-01-01

    A device capable of making in-flight volume measurements of single void urine samples, the Urine Monitoring System (UMS), was developed and flown on seven U.S. Space Shuttle missions. This device provided volume data for each urine void from multiple crewmembers and allowed samples of each to be taken and returned to Earth for post-flight analysis. There were a number of design flaws in the original instrument including the presence of liquid carry-over producing invalid "actual" micturition volumes and cross-contamination between successive users from residual urine in "dead" spots". Additionally, high or low volume voids could not be accurately measured, the on-orbit calibration and nominal use sequence was time intensive, and the unit had to be returned and disassembled to retrieve the volume data. These problems have been resolved in a new version, the International Space Station (ISS) UMS, that has been designed to provide real-time in-flight volume data with accuracy and precision equivalent to measurements made on Earth and the ability to provide urine samples that are unadulterated by the device. Originally conceived to be interfaced with a U.S.-built Waste Collection System (WCS), the unit now has been modified to interface with the Russian-supplied Sanitary Hygiene Device (ASY). The ISS UMS provides significant advantages over the current method of collecting urine samples into Urine Collection Devices (UCDs), from which samples are removed and returned to Earth for analyses. A significant future advantage of the UMS is that it can provide an interface to analytical instrumentation that will allow real-time measurement of urine bioanalytes allowing monitoring of crewmember health status during flight and the ability to provide medical interventions based on the results of these measurements. Currently, the ISS UMS is scheduled to launch along with Node-3 on STS-130 (20A) in December 2009. UMS will be installed and scientific/functional verification

  5. Genome analysis of Daldinia eschscholtzii strains UM 1400 and UM 1020, wood-decaying fungi isolated from human hosts

    SciTech Connect

    Chan, Chai Ling; Yew, Su Mei; Ngeow, Yun Fong; Na, Shiang Ling; Lee, Kok Wei; Hoh, Chee-Choong; Yee, Wai-Yan; Ng, Kee Peng

    2015-11-18

    Background: Daldinia eschscholtzii is a wood-inhabiting fungus that causes wood decay under certain conditions. It has a broad host range and produces a large repertoire of potentially bioactive compounds. However, there is no extensive genome analysis on this fungal species. Results: Two fungal isolates (UM 1400 and UM 1020) from human specimens were identified as Daldinia eschscholtzii by morphological features and ITS-based phylogenetic analysis. Both genomes were similar in size with 10,822 predicted genes in UM 1400 (35.8 Mb) and 11,120 predicted genes in UM 1020 (35.5 Mb). A total of 751 gene families were shared among both UM isolates, including gene families associated with fungus-host interactions. In the CAZyme comparative analysis, both genomes were found to contain arrays of CAZyme related to plant cell wall degradation. Genes encoding secreted peptidases were found in the genomes, which encode for the peptidases involved in the degradation of structural proteins in plant cell wall. In addition, arrays of secondary metabolite backbone genes were identified in both genomes, indicating of their potential to produce bioactive secondary metabolites. Both genomes also contained an abundance of gene encoding signaling components, with three proposed MAPK cascades involved in cell wall integrity, osmoregulation, and mating/filamentation. Besides genomic evidence for degrading capability, both isolates also harbored an array of genes encoding stress response proteins that are potentially significant for adaptation to living in the hostile environments. In conclusion: Our genomic studies provide further information for the biological understanding of the D. eschscholtzii and suggest that these wood-decaying fungi are also equipped for adaptation to adverse environments in the human host.

  6. Genome analysis of Daldinia eschscholtzii strains UM 1400 and UM 1020, wood-decaying fungi isolated from human hosts

    DOE PAGESBeta

    Chan, Chai Ling; Yew, Su Mei; Ngeow, Yun Fong; Na, Shiang Ling; Lee, Kok Wei; Hoh, Chee-Choong; Yee, Wai-Yan; Ng, Kee Peng

    2015-11-18

    Background: Daldinia eschscholtzii is a wood-inhabiting fungus that causes wood decay under certain conditions. It has a broad host range and produces a large repertoire of potentially bioactive compounds. However, there is no extensive genome analysis on this fungal species. Results: Two fungal isolates (UM 1400 and UM 1020) from human specimens were identified as Daldinia eschscholtzii by morphological features and ITS-based phylogenetic analysis. Both genomes were similar in size with 10,822 predicted genes in UM 1400 (35.8 Mb) and 11,120 predicted genes in UM 1020 (35.5 Mb). A total of 751 gene families were shared among both UM isolates,more » including gene families associated with fungus-host interactions. In the CAZyme comparative analysis, both genomes were found to contain arrays of CAZyme related to plant cell wall degradation. Genes encoding secreted peptidases were found in the genomes, which encode for the peptidases involved in the degradation of structural proteins in plant cell wall. In addition, arrays of secondary metabolite backbone genes were identified in both genomes, indicating of their potential to produce bioactive secondary metabolites. Both genomes also contained an abundance of gene encoding signaling components, with three proposed MAPK cascades involved in cell wall integrity, osmoregulation, and mating/filamentation. Besides genomic evidence for degrading capability, both isolates also harbored an array of genes encoding stress response proteins that are potentially significant for adaptation to living in the hostile environments. In conclusion: Our genomic studies provide further information for the biological understanding of the D. eschscholtzii and suggest that these wood-decaying fungi are also equipped for adaptation to adverse environments in the human host.« less

  7. A Visão do Universo Segundo a Concepção de um Grupo de Alunos do Ensino Médio de São Paulo

    NASA Astrophysics Data System (ADS)

    Araújo, M. A. A.; Elias, D. C. N.; Amaral, L. H.; Araújo, M. S. T.; Voelzke, M. R.

    2005-12-01

    Nesse trabalho foi identificada por meio de um questionário a visão de mundo sobre o Universo espaço e tempo entre 270 estudantes de Ensino Médio de três escolas de São Paulo. Constatou-se pouco conhecimento dos temas investigados sendo que apenas 20% dos alunos relacionaram as semanas com as fases da lua enquanto 28% associaram as estações do ano à inclinação do eixo de rotação da Terra e 23% tinham noções das distâncias entre objetos celestes próximos da Terra. Enquanto 56% conseguiram relacionar o Big Bang com a origem do Universo verificou-se que 37% reconheciam ano-luz como unidade de distância e 60% reconheciam o Sol como uma estrela. Apesar de 60% dos alunos indicarem a escola como principal fonte dos conhecimentos de astronomia seus conceitos ainda são inadequados havendo necessidade de aprimoramento da abordagem desses conteúdos pois apesar de popular a astronomia é veiculada de maneira pouco esclarecedora e com imprecissões.

  8. Preparación de los adultos mayores en los Estados Unidos para hacer frente a los desastres naturales: encuesta a escala nacional*

    PubMed Central

    Al-rousan, Tala M.; Rubenstein, Linda M.; Wallace, Robert B.

    2015-01-01

    Objetivos. Nos propusimos determinar el grado de preparación frente a los desastres naturales de los adultos mayores en los Estados Unidos y evaluar los factores que pueden afectar negativamente la salud y la seguridad durante este tipo de incidentes. Métodos. Obtuvimos una muestra de adultos de 50 años en adelante (n = 1 304) de la encuesta del 2010 del Estudio de la Salud y la Jubilación (HRS por su sigla en inglés). La encuesta recogió datos sobre las características demográficas generales, el estado de discapacidad o las limitaciones funcionales, y también sobre factores y comportamientos relacionados con la preparación frente a los desastres. Calculamos una puntuación global de preparación mediante indicadores individuales a fin de evaluar el grado de preparación general. Resultados. La media de la edad de los participantes (n = 1 304) fue de 70 años (desviación estándar [DE] = 9,3). Solo 34,3% informaron que habían participado en un programa formativo o que habían leído materiales sobre la preparación para los desastres. Casi 15% indicaron que usaban dispositivos médicos eléctricos que podían correr riesgo de no funcionar si se interrumpiera el suministro eléctrico. La puntuación de preparación indicó que la edad más avanzada, la discapacidad física y el menor nivel de escolaridad y de ingresos se asociaban independiente y significativamente a un grado de preparación general inferior. Conclusiones. A pesar de la mayor vulnerabilidad ante los desastres y del número cada vez mayor de adultos mayores en los Estados Unidos, muchos de los problemas sustanciales que encontramos son remediables y requieren atención en los sectores de la sociedad dedicados a la atención clínica, a la salud pública y al manejo de situaciones de emergencia.

  9. Assessment of Tropical Cyclone Track Forecast Errors using GDAPS (UM)

    NASA Astrophysics Data System (ADS)

    Kim, D.; Kim, J.; Chang, K.; Byun, K.; Lee, J.

    2013-12-01

    After the Joint Typhoon Warning Center (JTWC) began issuing official five-day tropical cyclone (TC) forecasts in 2003, the Korea Meteorological Administration (KMA) started issuing official five-day forecasts of TCs in May 2012 after 2 year of beta test. Forming a selective consensus (SCON) by proper removal of a likely erroneous track forecast is hypothesized to be more accurate than the non-selective consensus (NCON) of all model tracks that are used for the five-day forecasts. Conceptual models describing large track error mechanisms, which are related to known tropical cyclone motion processes being misrepresented in the dynamical models, are applied to forecasts during the 2012 western North Pacific typhoon season by the Global Data Assimilation and Prediction System (GDAPS (UM N512 L70)) which is KMA's main operational model. GDAPS (UM) is one of consensus members used in making KMA's five-day forecasts and thus analysis of its track error tendencies would be useful for forming a SCON forecast. All 72-h track errors greater than 320 km are examined on the basis of the approach developed by Carr and Elsberry (2000a, b). Tropical-influenced error sources caused 37% (47 times / 126 erroneous forecasts) of the GDAPS (UM) large track forecast errors primarily because an incorrect beta effect-related process depicted by the model contributed to the erroneous forecasts. Midlatitude-influenced error sources accounted for 63% (79 times / 126 error cases) in the GDAPS (UM) erroneous forecasts mainly due to an incorrect forecast of the midlatitude system evolutions. It is proposed that KMA will be able to issue more reliable TC track information if a likely model track error is recognized by optimum use of conceptual models by Carr and Elsberry (2000a, b) and a selective consensus track is then the basis for an improved warning.

  10. STAR CLUSTER COMPLEXES AND THE HOST GALAXY IN THREE H II GALAXIES: Mrk 36, UM 408, AND UM 461

    SciTech Connect

    Lagos, P.; Telles, E.; Nigoche-Netro, A.

    2011-11-15

    We present a stellar population study of three H II galaxies (Mrk 36, UM 408, and UM 461) based on the analysis of new ground-based high-resolution near-infrared J, H, and K{sub p} broadband and Br{gamma} narrowband images obtained with Gemini/NIRI. We identify and determine the relative ages and masses of the elementary star clusters and/or star cluster complexes of the starburst regions in each of these galaxies by comparing the colors with evolutionary synthesis models that include the contribution of stellar continuum, nebular continuum, and emission lines. We found that the current star cluster formation efficiency in our sample of low-luminosity H II galaxies is {approx}10%. Therefore, most of the recent star formation is not in massive clusters. Our findings seem to indicate that the star formation mode in our sample of galaxies is clumpy, and that these complexes are formed by a few massive star clusters with masses {approx}>10{sup 4} M{sub Sun }. The age distribution of these star cluster complexes shows that the current burst started recently and likely simultaneously over short timescales in their host galaxies, triggered by some internal mechanism. Finally, the fraction of the total cluster mass with respect to the low surface brightness (or host galaxy) mass, considering our complete range in ages, is less than 1%.

  11. Recovery Act: Novel Kerf-Free PV Wafering that provides a low-cost approach to generate wafers from 150um to 50um in thickness

    SciTech Connect

    Fong, Theodore E.

    2013-05-06

    The technical paper summarizes the project work conducted in the development of Kerf-Free silicon wafering equipment for silicon solar wafering. This new PolyMax technology uses a two step process of implantation and cleaving to exfoliate 50um to 120um wafers with thicknesses ranging from 50um to 120um from a 125mm or 156mm pseudo-squared silicon ingot. No kerf is generated using this method of wafering. This method of wafering contrasts with the current method of making silicon solar wafers using the industry standard wire saw equipment. The report summarizes the activity conducted by Silicon Genesis Corporation in working to develop this technology further and to define the roadmap specifications for the first commercial proto-type equipment for high volume solar wafer manufacturing using the PolyMax technology.

  12. Percepção astronómica de um grupo de alunos do ensino médio de uma escola da rede estadual de São Paulo

    NASA Astrophysics Data System (ADS)

    de Oliveria, E. F.; Voelzke, M. R.

    2009-03-01

    Sendo a Astronomia uma das cièncias mais antigas da humanidade, e considerando sua importáncia histórica e cultural, é de extrema releváncia que tópicos relacionados a ela sejam tratados nas escolas. Embora os Parámetros Curriculares Nacionais do Ensino Médio (PCN-EM) e as Orientaçiacute;es Complementares aos Parámetros (PCN+) apontem a importáncia de uma abordagem significativa de conceitos relacionados à Astronomia nas aulas de Física, muitos estudantes terminam o Ensino Médio (EM) sem compreender a razão de certos acontecimentos de origem celeste, ainda que estes façam parte de seu cotidiano e sejam alvos da curiosidade natural dos jovens. Da observação dessa curiosidade em alunos de uma escola pública paulista, na cidade de Suzano, surgiu o interesse em investigar os conhecimentos básicos em Astronomia dos alunos do Ensino Médio desta escola, constituindo-se este como principal objetivo desta pesquisa. Para tanto foi elaborado um questionário de múltipla escolha aplicado inicialmente a 34 alunos do primeiro ano e, posteriormente, a mais 310, distribuídos entre as très séries do Ensino Médio dos períodos matutino e noturno. Dessa forma, observou-se que 73,9% dos estudantes identificaram o Sol como sendo uma estrela, 67,1% mostraram compreender a sucessão entre dia e noite e 52,3% relacionaram o Big Bang à origem do Universo. Em contrapartida, apenas 34,5% relacionaram as estaçíes do ano à inclinação do eixo de rotação da Terra, 21,3% indicaram a influència gravitacional simultánea da Lua e do Sol como responsável pelo fenòmeno das marés, 24,5% indicaram corretamente quais são os objetos celestes mais próximos da Terra, 36,1% identificaram ano-luz como uma medida de distáncia e 34,2% reconheceram as estrelas cadentes como meteoros, evidenciando-se assim o pequeno discernimento dos estudantes quanto aos fenòmenos e termos astronòmicos do cotidiano. Além disso, foram comparadas as respostas de alun! os de diferentes s

  13. The Understanding of Astronomy Concepts by Students from Basic Education of a Public School. (Spanish Title: El Entendimiento de Conceptos de Aastronmía Por Los Alumnos de Educación Básica en Una Escuela Pública.) O Entendimento de Conceitos de Astronomia Por Alunos da Educação Básica: O Caso de Uma Escola Pública Brasileira

    NASA Astrophysics Data System (ADS)

    Iria Machado, Daniel; dos Santos, Carlos

    2011-07-01

    movimiento de la Luna, el movimiento aparente del Sol sobre la esfera celeste, los eclipses, las dimensiones y las distancias en el Universo, el brillo de las estrellas y su observación de la Tierra. Si bien ha habido un pequeño progreso en la proporción de respuestas aceptables científicamente cuando se cotejó el octavo grado de la enseñanza primaria con el quinto, y el último año de la enseñanza secundaria con el primero, se observó un predominio de las concepciones alternativas en relación a la mayoría de los temas explorados, que continuó hasta los últimos años de la educación básica. Una comparación con los datos encontrados en investigaciones realizadas en otros contextos socioculturales revelaron, en muchos aspectos, conceptos y dificultades similares expresadas por los estudiantes. Apresentam-se os resultados de uma investigação sobre a compreensão de conceitos astronômicos básicos, da qual participaram 561 estudantes da quinta série do Ensino Fundamental ao terceiro ano do Ensino Médio de uma escola pública da cidade de Foz do Iguaçu. Um teste com 20 questões de múltipla escolha foi aplicado para identificar as concepções mais comuns expressadas pelos alunos. Esse instrumento de coleta de dados foi elaborado com base na literatura sobre concepções alternativas e abordou os seguintes temas: o ciclo dia-noite; os fusos horários; as estações do ano; as fases da Lua; o movimento da Lua; o movimento aparente do Sol na esfera celeste; os eclipses; as dimensões e distâncias no Universo; o brilho das estrelas e sua observação da Terra. Embora se tenha verificado um pequeno progresso na proporção de respostas cientificamente aceitáveis ao se cotejar a oitava série do Ensino Fundamental com a quinta, e a terceira série do Ensino Médio com a primeira, houve o predomínio de concepções alternativas em relação à maior parte dos temas explorados, as quais persistiram até o último ano da Educação Básica. A comparação com

  14. The Understanding of Astronomy Concepts by Students from Basic Education of a Public School. (Spanish Title: El Entendimiento de Conceptos de Aastronmía Por Los Alumnos de Educación Básica en Una Escuela Pública.) O Entendimento de Conceitos de Astronomia Por Alunos da Educação Básica: O Caso de Uma Escola Pública Brasileira

    NASA Astrophysics Data System (ADS)

    Iria Machado, Daniel; dos Santos, Carlos

    2011-07-01

    movimiento de la Luna, el movimiento aparente del Sol sobre la esfera celeste, los eclipses, las dimensiones y las distancias en el Universo, el brillo de las estrellas y su observación de la Tierra. Si bien ha habido un pequeño progreso en la proporción de respuestas aceptables científicamente cuando se cotejó el octavo grado de la enseñanza primaria con el quinto, y el último año de la enseñanza secundaria con el primero, se observó un predominio de las concepciones alternativas en relación a la mayoría de los temas explorados, que continuó hasta los últimos años de la educación básica. Una comparación con los datos encontrados en investigaciones realizadas en otros contextos socioculturales revelaron, en muchos aspectos, conceptos y dificultades similares expresadas por los estudiantes. Apresentam-se os resultados de uma investigação sobre a compreensão de conceitos astronômicos básicos, da qual participaram 561 estudantes da quinta série do Ensino Fundamental ao terceiro ano do Ensino Médio de uma escola pública da cidade de Foz do Iguaçu. Um teste com 20 questões de múltipla escolha foi aplicado para identificar as concepções mais comuns expressadas pelos alunos. Esse instrumento de coleta de dados foi elaborado com base na literatura sobre concepções alternativas e abordou os seguintes temas: o ciclo dia-noite; os fusos horários; as estações do ano; as fases da Lua; o movimento da Lua; o movimento aparente do Sol na esfera celeste; os eclipses; as dimensões e distâncias no Universo; o brilho das estrelas e sua observação da Terra. Embora se tenha verificado um pequeno progresso na proporção de respostas cientificamente aceitáveis ao se cotejar a oitava série do Ensino Fundamental com a quinta, e a terceira série do Ensino Médio com a primeira, houve o predomínio de concepções alternativas em relação à maior parte dos temas explorados, as quais persistiram até o último ano da Educação Básica. A comparação com

  15. Heterogeneity in the therapeutic approach to relapsed elderly patients with acute myeloid leukaemia: a survey from the Gruppo Italiano Malattie Ematologiche dell' Adulto (GIMEMA) Acute Leukaemia Working Party.

    PubMed

    Ferrara, Felicetto; Fazi, Paola; Venditti, Adriano; Pagano, Livio; Amadori, Sergio; Mandelli, Franco

    2008-06-01

    The percentage of long-term survivors in acute myeloid leukaemia (AML) in the elderly does not exceed 10-15% of patients enrolled into clinical trials because of lower complete remission (CR) rates and higher incidence of relapse. However, few data are available as the treatment of elderly patients with relapsed disease is concerned. The aim of this study was of collecting data on criteria adopted for the treatment of these patients. A questionnaire was e-mailed to 32 haematologic institutions involved in the Gruppo Italiano per le Malattie Ematologiche dell'Adulto (GIMEMA) group. Questions to be addressed regarded: (1) per cent of relapsed elderly patients treated with aggressive salvage chemotherapy; (2) the selection criteria adopted for inclusion into intensive reinduction; (3) the specific treatment adopted; (4) the treatment given to patients not eligible for intensive salvage. Per cent of patients enrolled into aggressive salvage regimens varied from 10 to 80% (median 50%). The most frequent factor influencing the therapeutic choice was performance status (97%). Additional factors were age >70 years (44%) and duration of first CR (53%). Fludarabine including regimens were most frequently used as aggressive salvage therapy (59%), while gemtuzumab ozogamicin was adopted in various combinations at 11 out of 32 institutions (34%). For patients not eligible to aggressive therapy, the most frequent approach included hydroxyurea (59%). Low dose ARA-C (LDARA-C) was adopted at five centres: as single agent (n = 1), with 6-thioguanine (n = 1), with vitamin D3 and all-trans retinoic acid (ATRA) (n = 2), or with ATRA alone (n = 1). The FLT3 inhibitor CEP-701 was used at one centre. We conclude that the treatment of AML in elderly relapsed patients is extremely heterogeneous. A marked selection is operated as to inclusion into aggressive salvage regimens and only a small minority of patients are offered experimental approaches. PMID:18271064

  16. A VLT VIMOS integral-field spectroscopic study of perturbed blue compact galaxies: UM 420 and UM 462

    NASA Astrophysics Data System (ADS)

    James, B. L.; Tsamis, Y. G.; Barlow, M. J.

    2010-01-01

    We report on optical integral-field spectroscopy of two unrelated blue compact galaxies mapped with the 13× 13 arcsec2 Visible Multi-Object Spectrograph integral field unit at a resolution of 0.33× 0.33 arcsec2. Continuum and background subtracted emission line maps in the light of [OIII] λ5007, Hα and [NII] λ6584 are presented. Both galaxies display signs of ongoing perturbation and/or interaction. UM 420 is resolved for the first time to be a merging system composed of two starbursting components with an `arm-like' structure associated with the largest component. UM 462 which is a disrupted system of irregular morphology is resolved into at least four starbursting regions. Maps of the Hα radial velocity and full width at half-maximum are discussed. No underlying broad-line region was detected from either galaxy as the emission lines are well fitted with single Gaussian profiles only. Electron temperatures and densities as well as the abundances of helium, oxygen, nitrogen and sulphur were computed from spectra integrated over the whole galaxies and for each area of recent star formation. Maps of the O/H ratio are presented: these galaxies show oxygen abundances that are ~20 per cent solar. No evidence of substantial abundance variations across the galaxies that would point to significant nitrogen or oxygen self-enrichment is found (<~0.2 dex limit). Contrary to previous observations, this analysis does not support the classification of these blue compact dwarf galaxies as Wolf-Rayet galaxies as the characteristic broad-emission-line features have not been detected in our spectra. Baldwin-Phillips-Terlevich emission-line-ratio diagrams which were constructed on a pixel-by-pixel basis indicate that the optical spectra of these systems are predominantly excited by stellar photoionization. Based on observations collected at the European Southern Observatory (ESO), Chile, under programmes 078.B-0353(B, E). E-mail: bj@star.ucl.ac.uk

  17. Influence of a Novel Inhibitor (UM8190) of Prolylcarboxypeptidase (PRCP) on Appetite and Thrombosis

    PubMed Central

    Rabey, F. M.; Gadepalli, R.S.V.S.; Diano, S.; Cheng, Q.; Tabrizian, T.; Gailani, D.; Rimoldi, J.M.; Shariat-Madar, Z.

    2015-01-01

    Preclinical pharmacological characterization of a novel inhibitor (UM8190) of prolylcarboxypeptidase (PRCP) was investigated. We synthesized and evaluated a library of proline-based analogs as prospective recombinant PRCP (rPRCP) inhibitors and inhibitors of PRCP-dependent prekallikrein (PK) activation on human pulmonary artery endothelial cells (HPAEC). Among the newly synthesized compounds, UM8190 was further characterized in vivo using methods that encompassed a mouse carotid artery thrombosis model and animal model of food consumption. (S)-N-dodecyl-1-((S)-pyrrolidine-2-carbonyl) pyrrolidine-2-carboxamide [Compound 3 (UM8190)] was selected for further evaluation from the initial assessment of its PRCP inhibitory action (Ki= 43 µM) coupled with its ability to block PRCP-dependent PK activation on HPAEC (Ki= 34 µM). UM8190 demonstrated excellent selectivity against a panel of carboxypeptidases and serine proteases and blocked bradykinin (BK) generation and BK-induced permeability by 100%, suggesting that it may be useful in preventing the local production of large amounts of BK. Furthermore, UM8190 showed an anorexigenic effect when systemically administered to fasted mice, reducing food intake in a dose- and time-dependent manner. In a mouse carotid artery thrombosis model, it also demonstrated an antithrombotic effect. UM8190 is a selective PRCP inhibitor and it may represent a new anorexigenic, and antithrombotic drug, that works by inhibiting PRCP–mediated mechanisms. PMID:22664251

  18. UM-PRS: An implementation of the procedural reasoning system for multirobot applications

    NASA Technical Reports Server (NTRS)

    Lee, Jaeho; Huber, Marcus J.; Durfee, Edmund H.; Kenny, Patrick G.

    1994-01-01

    The Procedural Reasoning System (PRS) is used in applications where predetermined situations might arise. The UM-PRS provides a reasoning system that represents robotic applications even in unpredictable domains, such as the robotic reconnaissance task domain outlined here. UM-PRS incorporates a changing context, rather than relying solely on a prearranged plan. The UM-PRS here provides representation important in the reasoning and interface between a mission plan and the executable map of an outdoor vehicle that changes its behavior based on what it comes in contact with in its environment. PRS is thus used in the dynamic control of such a vehicle, providing the basis for coordinating the joint task of multiple robotic vehicles by the their individual observations and representation.

  19. Protective Effects of Ultramicronized Palmitoylethanolamide (PEA-um) in Myocardial Ischaemia and Reperfusion Injury in VIVO.

    PubMed

    Di Paola, Rosanna; Cordaro, Marika; Crupi, Rosalia; Siracusa, Rosalba; Campolo, Michela; Bruschetta, Giuseppe; Fusco, Roberta; Pugliatti, Pietro; Esposito, Emanuela; Cuzzocrea, Salvatore

    2016-08-01

    Myocardial infarction is the leading cause of death, occurs after prolonged ischemia of the coronary arteries. Restore blood flow is the first intervention help against heart attack. However, reperfusion of the arteries leads to ischemia/reperfusion injury (I/R). The fatty acid amide palmitoylethanolamide (PEA) is an endogenous compound widely present in living organisms, with analgesic and anti-inflammatory properties. The present study evaluated the effect of ultramicronized palmitoylethanolamide (PEA-um) treatment on the inflammatory process associated with myocardial I/R. Myocardial ischemia reperfusion injury was induced by occlusion of the left anterior descending coronary artery for 30 min followed by 2 h of reperfusion. PEA-um, was administered (10 mg/kg) 15 min after ischemia and 1 h after reperfusion. In this study, we demonstrated that PEA-um treatment reduces myocardial tissue injury, neutrophil infiltration, adhesion molecules (ICAM-1, P-selectin) expression, proinflammatory cytokines (TNF-α, IL-1β) production, nitrotyrosine and PAR formation, nuclear factor kB expression, and apoptosis (Fas-L, Bcl-2) activation. In addition to study whether the protective effect of PEA-um on myocardial ischemia reperfusion injury is also related to the activation of PPAR-α, in a separate set of experiments it has been performed myocardial I/R in PPARα mice. Genetic ablation of peroxisome proliferator activated receptor (PPAR)-α in PPAR-αKO mice exacerbated Myocardial ischemia reperfusion injury when compared with PPAR-αWT mice. PEA-um induced cardioprotection in PPAR-α wild-type mice, but the same effect cannot be observed in PPAR-αKO mice. Our results have clearly shown a modulation of the inflammatory process, associated with myocardial ischemia reperfusion injury, following administration of PEA-um. PMID:26844976

  20. METHOD 100.2 - DETERMINATION OF ASBESTOS STRUCTURES OVER 10 UM IN LENGTH IN DRINKING WATER

    EPA Science Inventory

    Water is collected in a polyethylene or glass container and shipped to the laboratory. nown aliquots of the sample are filtered through a 0.1 to 0.22 um pore mixed cellulose ester (MCE). arbon extraction replica is prepared from a portion of the filter and is examined in the TEM ...

  1. Use of "um" in the Deceptive Speech of a Convicted Murderer

    ERIC Educational Resources Information Center

    Villar, Gina; Arciuli, Joanne; Mallard, David

    2012-01-01

    Previous studies have demonstrated a link between language behaviors and deception; however, questions remain about the role of specific linguistic cues, especially in real-life high-stakes lies. This study investigated use of the so-called filler, "um," in externally verifiable truthful versus deceptive speech of a convicted murderer. The data…

  2. Descoberta de um aglomerado estelar massivo associado a fonte IRAS 16177-5018

    NASA Astrophysics Data System (ADS)

    Roman Lopes, A.; Abraham, Z.; Lépine, J. R. D.

    2003-08-01

    Neste trabalho apresentamos a descoberta de um aglomerado de estrelas jovens e massivas embebido em uma região HII extensa associado com a fonte IRAS 16177-5018, que se apresenta invisível na faixa óptica do espectro eletromagnético, onde a extinção é da ordem de AV = 26 magnitudes. As observações foram feitas com a camera infravermelha (CamIV) do Laboratório Nacional de Astrofísica, Brasil, equipada com um detector Hawaii de HgCdTe de 1024´1024 pixel acoplada ao telescópio de 60 cm Boller & Chivens do IAG. A fotometria obtida a partir das imagens nas bandas J, H e K (filtro estreito) mostrou a presença de fontes com excesso de emissão no infravermelho em 2.2 mm, concentradas em uma área de aproximadamente um minuto de arco quadrado em torno da nebulosa na qual esta embebido o objeto identificado como a fonte IRAS. A fonte IRAS apresenta um índice espectral (entre 2.2 21.3 mm) a = d log(l Fl) / d log l = 4.78, característico de um objeto extremamente jovem com luminosidade bolométrica (obtida da integral da densidade de fluxo entre o infravermelho próximo (1.25mm) e o infravermelho distante (100mm)) de 2.8´105L¤, o qual corresponde a uma estrela da sequência principal de idade zero de cerca de 42 M¤. A partir do diagrama cor-magnitude foi possível classificar a maioria dos membros do aglomerado como estrelas massivas mais luminosas que tipo espectral B5.

  3. Uh, Um, and Autism: Filler Disfluencies as Pragmatic Markers in Adolescents with Optimal Outcomes from Autism Spectrum Disorder.

    PubMed

    Irvine, Christina A; Eigsti, Inge-Marie; Fein, Deborah A

    2016-03-01

    Filler disfluencies--uh and um--are thought to serve distinct discourse functions. We examined fillers in spontaneous speech by youth with autism spectrum disorder (ASD), who struggle with pragmatic language, and by youth with ASD who have achieved an 'optimal outcome' (OO), as well as in peers with typical development (TD). While uh rates did not differ, participants with ASD produced um less frequently than OO or TD groups. Um rate was associated with autism symptom severity, but not executive function or language abilities, suggesting that um serves a pragmatic, listener-oriented function. Moreover, in contrast to minimal production in ASD, the typical OO um production substantiates the normalization of subtle social communication in this population. PMID:26586555

  4. The merging dwarf galaxy UM 448: chemodynamics of the ionized gas from VLT integral field spectroscopy

    NASA Astrophysics Data System (ADS)

    James, B. L.; Tsamis, Y. G.; Barlow, M. J.; Walsh, J. R.; Westmoquette, M. S.

    2013-01-01

    Using Very Large Telescope/Fibre Large Array Multi Element Spectrograph optical integral field unit observations, we present a detailed study of UM 448, a nearby blue compact galaxy (BCG) previously reported to have an anomalously high N/O abundance ratio. New Technology Telescope/Superb-Seeing Imager images reveal a morphology suggestive of a merger of two systems of contrasting colour, whilst our Hα emission maps resolve UM 448 into three separate regions that do not coincide with the stellar continuum peaks. UM 448 exhibits complex emission line profiles, with most lines consisting of a narrow [full width at half-maximum (FWHM) ≲ 100 km s-1], central component, an underlying broad component (FWHM ˜ 150-300 km s-1) and a third, narrow blueshifted component. Radial velocity maps of all three components show signs of solid body rotation across UM 448, with a projected rotation axis that correlates with the continuum morphology of the galaxy. A spatially resolved, chemodynamical analysis, based on the [O iii] λλ4363, 4959, [N ii] λ6584, [S ii] λλ6716, 6731 and [Ne iii] λ3868 line maps, is presented. Whilst the eastern tail of UM 448 has electron temperatures (Te) that are typical of BCGs, we find a region within the main body of the galaxy where the narrow and broad [O iii] λ4363 line components trace temperatures differing by 5000 K and oxygen abundances differing by 0.4 dex. We measure spatially resolved and integrated ionic and elemental abundances for O, N, S and Ne throughout UM 448, and find that they do not agree, possibly due the flux weighting of Te from the integrated spectrum. This has significant implications for abundances derived from long-slit and integrated spectra of star-forming galaxies in the nearby and distant universe. A region of enhanced N/O ratio is indeed found, extended over a ˜0.6 kpc2 region within the main body of the galaxy. Contrary to previous studies, however, we do not find evidence for a large Wolf-Rayet (WR

  5. Observations of the new gravitational lens system UM 673 = Q 0142-100

    NASA Astrophysics Data System (ADS)

    Surdej, J.; Magain, P.; Swings, J.-P.; Borgeest, U.; Courvoisier, T. J.-L.; Kayer, R.; Kellermann, K. I.; Kuhr, H.; Refsdal, S.

    1988-06-01

    The authors have recently initiated a high resolution direct imaging survey of a selected sample of highly luminous quasars (HLQs). The observations are carried out with the 2.2 m telescope at ESO, and with the VLA at the NRAO, New Mexico. Following the first observing run at ESO, the authors have reported the discovery of a new gravitational lens system for the HLQ UM 673 = Q 0142-100. Additional observations supporting this interpretation are discussed here. Application of gravitational optometry to this system is given: a value of M0 = 2.4×1011M_sun; is derived for the mass of the lensing galaxy located between UM 673 A and B and a most likely estimate of Δt = 7 weeks is found for the expected delay between the arrival times of a similar variability event in the two lensed images of the quasar (H0 = 75 km s-1Mpc-1, q0 = 0).

  6. VizieR Online Data Catalog: Subaru H images of UM673 (Koptelova+, 2014)

    NASA Astrophysics Data System (ADS)

    Koptelova, E.; Chiueh, T.; Chen, W. P.; Chan, H.-H.

    2014-05-01

    We carried out H-band observations of UM673 with the Subaru Infra-Red Camera and Spectrograph (IRCS) using an adaptive optics system with 188 control elements (AO188). The images were reduced following the procedure described in "Subaru Data Reduction CookBook: Imaging Observation with IRCS" by Y. Minowa (see also Minowa et al. 2005ApJ...629...29M). The final Subaru H-band stack image of UM673 was created by coadding 22 reduced single exposure images. We also created the exposure time map of the stack image. The 17x10arcsec subframe of the stack image and the corresponding exposure map displayed in Figures 1 and 2 of the paper are available as fits files. (2 data files).

  7. Fermentation optimization for the production of bioactive polysaccharides from Cordyceps sinensis fungus UM01.

    PubMed

    Wang, Lan-Ying; Cheong, Kit-Leong; Wu, Ding-Tao; Meng, Lan-Zhen; Zhao, Jing; Li, Shao-Ping

    2015-08-01

    The optimal fermentation conditions and medium for the production of bioactive polysaccharides from the mycelium of Cordyceps sinensis fungus UM01 were investigated by using orthogonal design and high performance size exclusion chromatography coupled with multi-angel laser light scattering and refractive index detector (HPSEC-MALLS-RID). Results showed that the optimal temperature, initial pH, rotation speed, medium capacity (ratio of medium volume to the volume of flask bottle) and inoculums volume for the mycelium growth were 15 °C, pH 6.0, 150 rpm, 2/5 (v/v), and 3% (v/v), respectively. Furthermore, bioactive polysaccharides from the mycelium of C. sinensis fungus UM01 were determined as polysaccharide fractions with the molecular weight above 10 kDa. The optimal fermentation medium was determined as a composition of glucose 30.0 g/L, sucrose 30.0 g/L, KH2PO4 1.0 g/L, CaCl2 0.5 g/L, yeast extract 3.0 g/L, and MgCl2 0.1g/L according to the maximum amount of the bioactive polysaccharides (486.16±19.60 mg/L) measured by HPSEC-MALLS/RID. Results are helpful to establish an efficient and controllable fermentation process for the industrial production of bioactive polysaccharides from C. sinensis UM01, and beneficial to develop a unique health and functional product in future. PMID:25936285

  8. Implementação de um algoritmo para a limpeza de mapas da RCFM

    NASA Astrophysics Data System (ADS)

    Souza, C. L.; Wuensche, C. A.

    2003-08-01

    A Radiação Cósmica de Fundo em Microondas (RCFM), descoberta por Penzias e Wilson em 1965, é uma das ferramentas mais poderosas para o estudo da cosmologia. Com a descoberta de flutuações de temperatura na RCFM, da ordem de uma parte em 105, pelo COBE (1992), uma nova era teve início. Nos últimos onze anos, diversos instrumentos fizeram novas medidas de alta precisão, refinando os resultados apresentados pelo COBE, culminando com os resultados recentes do satélite WMAP. A análise de dados da RCFM, especialmente no caso de experimentos com pequena cobertura do céu, apresenta uma série de dificuldades devido a emissões de contaminantes externos, tais como a emissão da Galáxia e de fontes pontuais, e de ruídos intrínsecos tanto ao sistema de detecção quanto à estratégia de observação do céu. Uma das soluções típicas para a filtragem de dados brutos de um experimento para medir flutuações de temperatura é aplicar um gabarito (template) e um filtro passa alta ao produzir mapas simplificados (sem considerar matrizes de correlação ou covariância). No caso de experimentos que utilizam detectores HEMT, essa combinação de filtros remove, satisfatoriamente, ruídos do tipo 1/f gerados pela instabilidade no ganho do detector acoplado ao movimento do instrumento, definido pela estratégia de observação. Entretanto, o sinal resultante medido, tanto em simulações quanto em séries temporais reais, sugere que parte do sinal cosmológico pode estar sendo removido junto com o ruído dos detectores. Este trabalho descreve as etapas para a produção de um mapa típico (simulado) e os testes preliminares de um algoritmo para remover ruídos do tipo 1/f introduzidos pela estratégia de observação sem prejudicar a qualidade do sinal cosmológico presente no mapa.

  9. Seminario Tecnico Regional Sobre Alternativas de Educacion Basica de Adultos en el Marco de la REDALF del Proyecto Principal de Educacion en America Latina y el Caribe (Colonia Tovar, Venezuela, 29 de Septiembre al 3 de Octubre, 1986). Documento Final. (Regional Seminar on Alternatives for Basic Adult Education in the REDALF Project for Education in Latin America and the Caribbean (Colonia Tovar, Venezuela, September 29-October 3, 1986). Final Document.)

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Santiago (Chile). Regional Office for Education in Latin America and the Caribbean.

    The final report of a conference concerning adult basic education de Adultos en el Marco de la REDALF del related to innovative projects in adult education in nine countries. A wide spectrum of issues related to adult basic education, curriculum, methodology, evaluation, and research are analyzed in the context of educational planning. Among the…

  10. VizieR Online Data Catalog: 11.5um image of NGC 835 (Gonzalez-Martin+, 2016)

    NASA Astrophysics Data System (ADS)

    Gonzalez-Martin, O.; Hernandez-Garcia, L.; Masegosa, J.; Marquez, I.; Rodriguez-Espinosa, J. M.; Acosta-Pulido, J. A.; Alonso-Herrero, A.; Dultzin, D.; Espaza Arredondo, D.

    2015-11-01

    We present the first sub-arcsecond resolution mid-infrared imaging of NGC 835. This nucleus was observed with Canari-cam/GTC on 23 September 2014. Images were taken using the Si5 filter (at 11.5um with an effective width of 0.9um) in two separate observing blocks with a total on-source time of 993s. (2 data files).

  11. Design of a ROIC with 15um pitch for MWIR FPAs

    NASA Astrophysics Data System (ADS)

    Liang, Qinghua; Jiang, Dazhao; Chen, Honglei; Zhang, Qiwen; Ding, Ruijun

    2015-10-01

    A 640×512 readout integrated circuit (ROIC) with 15um pixel pitch for middle-wave infrared focal plane arrays (MWIR FPAs) is designed in this paper. The 15um pixel pitch presents several challenges to the ROIC design, such as achieving the required charge storage capacity to preserve the high SNR and reading or processing the pixel signals correctly to achieve the required frame rate. A novel structure that four neighboring pixels share one integration capacitor is presented as a feasible approach to getting a large charge capacity in the limited pixel area. Meanwhile, the pixel circuit chooses the direct injection (DI) which occupies the small layout area as the input stage for MW and contains two sample and hold modules to further increase the charge capacity. Moreover,the peripheral analog signal chain circuit, which is composed of a PMOS source follower, a column amplifier and the complementary output stage, is designed to transfer the signals from unit cell with less voltage loss,lower power consumption, lower noise and higher linearity. More importantly, in our design, only half chain circuit are required therefore the corresponding power consumption will be reduced greatly. In order to accommodate this design, two kinds of pixel signal readout sequences are compared. By adopting the 0.18um 1P6M mixed signal CMOS process, the circuit architecture can make the effective charge capacity of 13Me- per pixel with 1.38V final output range. The 4×4 circuit layout will be fulfilled as a whole and in this way the effective integration capacitor can be increased. According to the simulation results, this circuit works well under 3.3V power supply and achieves 10MHZ readout rate and less than 0.1% nonlinearity.

  12. Isoalantolactone Inhibits UM-SCC-10A Cell Growth via Cell Cycle Arrest and Apoptosis Induction

    PubMed Central

    Wu, Minjun; Zhang, Hua; Hu, Jiehua; Weng, Zhiyong; Li, Chenyuan; Li, Hong; Zhao, Yan; Mei, Xifan; Ren, Fu; Li, Lihua

    2013-01-01

    Isoalantolactone is a sesquiterpene lactone compound isolated from the roots of Inula helenium L. Previous studies have demonstrated that isoalantolactone possesses antifungal, anti-bacterial, anti-helminthic and anti-proliferative properties in a variety of cells, but there are no studies concerning its effects on head and neck squamous cell carcinoma (HNSCC). In the present study, an MTT assay demonstrated that isoalantolactone has anti-proliferative activity against the HNSCC cell line (UM-SCC-10A). Immunostaining identified that this compound induced UM-SCC-10A cell apoptosis but not necrosis. To explain the molecular mechanisms underlying its effects, flow cytometry and western blot analysis showed that the apoptosis was associated with cell cycle arrest during the G1 phase, up-regulation of p53 and p21, and down-regulation of cyclin D. Furthermore, our results revealed that induction of apoptosis through a mitochondrial pathway led to up-regulation of pro-apoptotic protein expression (Bax), down-regulation of anti-apoptotic protein expression (Bcl-2), mitochondrial release of cytochrome c (Cyto c), reduction of mitochondrial membrane potential (MMP) and activation of caspase-3 (Casp-3). Involvement of the caspase apoptosis pathway was confirmed using caspase inhibitor Z-VAD-FMK pretreatment. Together, our findings suggest that isoalantolactone induced caspase-dependent apoptosis via a mitochondrial pathway and was associated with cell cycle arrest in the G1 phase in UM-SCC-10A cells. Therefore, isoalantolactone may become a potential drug for treating HNSCC. PMID:24098753

  13. Traitement chirurgical des fractures articulaires du calcanéum par plaque vissée

    PubMed Central

    Hammou, Nassreddine; Abid, Hatim; Shimi, Mohammed; El Ibrahimi, Abdelhalim; El Mrini, Abdelmajid

    2015-01-01

    Les fractures du calcanéum sont peu fréquentes mais le plus souvent graves. Le traitement chirurgical par plaque vissée est ardemment défendu. L'objectif de notre travail rétrospectif est d’évaluer les résultats du traitement chirurgical des fractures articulaires du calcanéum à travers une série de 12 patients opérée aux service d'orthopédie du CHU Hassan II de Fès sur une durée de 3 ans, et les comparer aux données de la littérature. L’âge moyen dans notre série était de 34 ans, le geste opératoire était réalisé au 7ème jour. Tous nos patient ont bénéficie d'une réduction à foyer ouvert avec une ostéosynthèse par plaques vissées. Le recul moyen était de 12 mois et les résultats fonctionnels ont été évaluer selon le score de Kitaoka. PMID:26161214

  14. Uh and um in children with autism spectrum disorders or language impairment.

    PubMed

    Gorman, Kyle; Olson, Lindsay; Hill, Alison Presmanes; Lunsford, Rebecca; Heeman, Peter A; van Santen, Jan P H

    2016-08-01

    Atypical pragmatic language is often present in individuals with autism spectrum disorders (ASD), along with delays or deficits in structural language. This study investigated the use of the "fillers" uh and um by children ages 4-8 during the autism diagnostic observation schedule. Fillers reflect speakers' difficulties with planning and delivering speech, but they also serve communicative purposes, such as negotiating control of the floor or conveying uncertainty. We hypothesized that children with ASD would use different patterns of fillers compared to peers with typical development or with specific language impairment (SLI), reflecting differences in social ability and communicative intent. Regression analyses revealed that children in the ASD group were much less likely to use um than children in the other two groups. Filler use is an easy-to-quantify feature of behavior that, in concert with other observations, may help to distinguish ASD from SLI. Autism Res 2016, 9: 854-865. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. PMID:26800246

  15. Wissenschaft, die unsere Kultur verändert. Tiefenschichten des Streits um die Evolutionstheorie

    NASA Astrophysics Data System (ADS)

    Patzelt, Werner J.

    Die Evolutionstheorie ist eine der erfolgreichsten wissenschaftlichen Theorien. Sie erlaubt es, unsere Herkunft zu verstehen und riskante Merkmale gerade der menschlichen Spezies zu begreifen. Zugleich ist die Evolutionstheorie eine der umstrittensten Theorien. Das liegt nicht an ihrer empirischen Tragfähigkeit, sondern an ihrem Gegenstand. Sie handelt nämlich nicht nur - wie Hunderte andere wissenschaftliche Theorien - von der "Welt da draußen“, sondern vor allem auch von uns selbst und von unserem Platz in dieser Welt. Den einen gilt sie obendrein als Überwinderin religiösen Aberglaubens, den anderen als neuer Zugang zu Gott und seinem Wirken in der Welt. Ferner sehen die einen in der Evolution eine unbezweifelbare Tatsache gleich der Schwerkraft oder dem Holocaust, die anderen aber eine - noch oder dauerhaft - unbewiesene Hypothese oder gar eine falsche Schöpfungslehre. Und während die meisten Streitfragen solcher Art nach wechselseitig akzeptierten Regeln ‚normaler Wissenschaft‘ geklärt werden, wird bei der Frage nach dem Woher unserer Spezies und Kultur die intellektuelle Zuständigkeit von Wissenschaft mitunter überhaupt bezweifelt. Anscheinend geht es schon um recht tiefe Schichten unserer Kultur und nicht nur der wissenschaftlichen, wenn - wie seit 150 Jahren - um die Evolutionstheorie gestritten wird. Wie sehen diese Schichten aus?

  16. Factores socio-económicos asociados a la percepción de situación socioeconómica entre adultos mayores de dos países latinoamericanos

    PubMed Central

    Brenes-Camacho, Gilbert

    2014-01-01

    El objetivo principal del artículo es estudiar la asociación entre la percepción subjetiva sobre la situación económica propia y una serie de medidas objetivas de bienestar socioeconómico –fuentes de ingresos, tenencia de vivienda, nivel educativo y transferencias familiares informales de dinero- entre adultos mayores de dos países Latinoamericanos: México y Costa Rica. Los datos se obtienen de las primeras rondas de dos encuestas sobre envejecimiento: CRELES para Costa Rica y ENASEM para México. La variable dependiente más importante se obtiene de las respuestas a las pregunta “¿Cómo califica su situación económica actual?” en Costa Rica y “¿Diría usted que su situación económica es…?” en México. Para ambas encuestas, las respuestas se codificaron en forma binaria; el código 0 representa las categorías Excelente, Muy buena y Buena, y el código 1 representa a las categorías Regular y Mala. Se encontró que el ingreso por jubilación es un importante determinante de la percepción de bienestar en ambos países. En Costa Rica, el ingreso del cónyuge y la tenencia de vivienda son importantes predictores de la percepción de bienestar, mientras que en México, los ingresos por transferencias están fuertemente asociados con dicha percepción. PMID:25360057

  17. Clinical Performance and Management Outcomes with the DecisionDx-UM Gene Expression Profile Test in a Prospective Multicenter Study

    PubMed Central

    Plasseraud, Kristen Meldi; Tsai, Tony; Shildkrot, Yevgeniy; Middlebrook, Brooke; Maetzold, Derek; Wilkinson, Jeff; Stone, John; Johnson, Clare; Oelschlager, Kristen; Aaberg, Thomas M.

    2016-01-01

    Uveal melanoma management is challenging due to its metastatic propensity. DecisionDx-UM is a prospectively validated molecular test that interrogates primary tumor biology to provide objective information about metastatic potential that can be used in determining appropriate patient care. To evaluate the continued clinical validity and utility of DecisionDx-UM, beginning March 2010, 70 patients were enrolled in a prospective, multicenter, IRB-approved study to document patient management differences and clinical outcomes associated with low-risk Class 1 and high-risk Class 2 results indicated by DecisionDx-UM testing. Thirty-seven patients in the prospective study were Class 1 and 33 were Class 2. Class 1 patients had 100% 3-year metastasis-free survival compared to 63% for Class 2 (log rank test p = 0.003) with 27.3 median follow-up months in this interim analysis. Class 2 patients received significantly higher-intensity monitoring and more oncology/clinical trial referrals compared to Class 1 patients (Fisher's exact test p = 2.1 × 10−13 and p = 0.04, resp.). The results of this study provide additional, prospective evidence in an independent cohort of patients that Class 1 and Class 2 patients are managed according to the differential metastatic risk indicated by DecisionDx-UM. The trial is registered with Clinical Application of DecisionDx-UM Gene Expression Assay Results (NCT02376920). PMID:27446211

  18. Clinical Performance and Management Outcomes with the DecisionDx-UM Gene Expression Profile Test in a Prospective Multicenter Study.

    PubMed

    Plasseraud, Kristen Meldi; Cook, Robert W; Tsai, Tony; Shildkrot, Yevgeniy; Middlebrook, Brooke; Maetzold, Derek; Wilkinson, Jeff; Stone, John; Johnson, Clare; Oelschlager, Kristen; Aaberg, Thomas M

    2016-01-01

    Uveal melanoma management is challenging due to its metastatic propensity. DecisionDx-UM is a prospectively validated molecular test that interrogates primary tumor biology to provide objective information about metastatic potential that can be used in determining appropriate patient care. To evaluate the continued clinical validity and utility of DecisionDx-UM, beginning March 2010, 70 patients were enrolled in a prospective, multicenter, IRB-approved study to document patient management differences and clinical outcomes associated with low-risk Class 1 and high-risk Class 2 results indicated by DecisionDx-UM testing. Thirty-seven patients in the prospective study were Class 1 and 33 were Class 2. Class 1 patients had 100% 3-year metastasis-free survival compared to 63% for Class 2 (log rank test p = 0.003) with 27.3 median follow-up months in this interim analysis. Class 2 patients received significantly higher-intensity monitoring and more oncology/clinical trial referrals compared to Class 1 patients (Fisher's exact test p = 2.1 × 10(-13) and p = 0.04, resp.). The results of this study provide additional, prospective evidence in an independent cohort of patients that Class 1 and Class 2 patients are managed according to the differential metastatic risk indicated by DecisionDx-UM. The trial is registered with Clinical Application of DecisionDx-UM Gene Expression Assay Results (NCT02376920). PMID:27446211

  19. Detector Technologies for Sub-500um High-Sensitivity PET Imaging via a Novel PET Insert Approach

    SciTech Connect

    Tai, Yuan-Chuan

    2011-12-21

    The objective of this project was to develop detector technologies that would enable an ultrahigh resolution Virtual Pinhole (VP) PET insert device to provide sub-500 um resolution high-sensitivity PET imaging of a mouse in the future. To achieve this goal, we proposed to develop and characterize finely pixellated cadmium zinc telluride (CZT) detectors and the associated readout electronics with the following specific aims: 1. Develop pixellated CZT detectors with 350um pitches using 2-5 mm substrates; characterize their spatial, energy and timing performance through experiments; and optimize the anode design with steering grid if found necessary. 2. Develop a high-bandwidth readout system using a novel ASIC that can be directly bonded to CZT detectors with 2048 anodes of 350um pitches; optimize its overall performance for VP-PET applications considering the tradeoffs between spatial resolution (in 3D), count rate capability, timing and energy resolutions. 3. Evaluate the performance of a VP-PET insert based on the proposed detector technology through Monte Carlo simulation and experimental validation. Overall, we have completed all three specific aims and demonstrated that pixelated CZT detectors of 350um pitches, combined with VP-PET geometry, can provide PET image resolution of ~460 um FWHM for small animal imaging applications.

  20. Draft Genome Sequence of the Biocontrol and Plant Growth-Promoting Rhizobacterium Pseudomonas fluorescens strain UM270.

    PubMed

    Hernández-Salmerón, Julie E; Hernández-León, Rocio; Orozco-Mosqueda, Ma Del Carmen; Valencia-Cantero, Eduardo; Moreno-Hagelsieb, Gabriel; Santoyo, Gustavo

    2016-01-01

    The Pseudomonas fluorescens strain UM270 was isolated form the rhizosphere of wild Medicago spp. A previous work has shown that this pseudomonad isolate was able to produce diverse diffusible and volatile compounds involved in plant protection and growth promotion. Here, we present the draft genome sequence of the rhizobacterium P. fluorescens strain UM270. The sequence covers 6,047,974 bp of a single chromosome, with 62.66 % G + C content and no plasmids. Genome annotations predicted 5,509 genes, 5,396 coding genes, 59 RNA genes and 110 pseudogenes. Genome sequence analysis revealed the presence of genes involved in biological control and plant-growth promoting activities. We anticipate that the P. fluorescens strain UM270 genome will contribute insights about bacterial plant protection and beneficial properties through genomic comparisons among fluorescent pseudomonads. PMID:26767092

  1. Comparative genomic analysis of Mycobacterium iranicum UM_TJL against representative mycobacterial species suggests its environmental origin

    PubMed Central

    Tan, Joon Liang; Ngeow, Yun Fong; Wee, Wei Yee; Wong, Guat Jah; Ng, Hien Fuh; Choo, Siew Woh

    2014-01-01

    Mycobacterium iranicum is a newly reported mycobacterial species. We present the first comparative study of M. iranicum UM_TJL and other mycobacteria. We found M. iranicum to have a close genetic association with environmental mycobacteria infrequently associated with human infections. Nonetheless, UM_TJL is also equipped with many virulence genes (some of which appear to be the consequence of transduction-related gene transfer) that have been identified in established human pathogens. Taken all together, our data suggest that M. iranicum is an environmental bacterium adapted for pathogenicity in the human host. This comparative study provides important clues and forms the basis for future functional studies on this mycobacterium. PMID:25417557

  2. Localization of the 5f level across the UM 5-xT x series

    NASA Astrophysics Data System (ADS)

    Zoł; nierek, Z̵.; Troc, R.; Tran, V. H.

    1990-04-01

    We review the results of bulk measurements on selected pseudoternary compounds within the UM 5- xT x system where M = Cu, Ni and Pt, and T = Ag, Au, Pd and Ir. These ternary compounds crystallize in the cubic AuBe 5 crystal structure. The results obtained on about 20 specimens clearly show that the 5f-localization of the uranium depends on the degree of f-d and/or f-s hybridization. The strength of the hybridization is a function of the concentration of s- and d-conduction electrons and is controlled chemically by the extent of the “M 5- xT x” alloying.

  3. Ensino de astronomia no 1o. e 2o. ciclos do nível fundamental e na educação de jovens e adultos: exemplos e discussões

    NASA Astrophysics Data System (ADS)

    Queiroz, A. S. B.; Jafelice, L. C.

    2003-08-01

    Tem-se constatado uma preocupante carência no ensino de astronomia nos diversos níveis de escolaridade. Neste trabalho discutimos várias práticas didático-pedagógicas que vimos desenvolvendo para crianças, jovens e adultos em processo de alfabetização, visando contribuir para reparar aquela carência. Propomos uma metodologia que incorpora as recentes exigências das políticas públicas educacionais, estimula o desenvolvimento de textos e materiais instrucionais, é compatível com a realidade desse público e é adaptável às respectivas faixas etárias. A observação do céu sempre esteve presente na vida de nossos antepassados, dando suporte à compreensão do ser humano como integrante da natureza. Visamos com este trabalho suprir a deficiência encontrada para se tratar a relação do ser humano com o céu, no ambiente escolar. Os resultados são animadores e envolvem práticas e textos que desenvolvemos e atividades realizadas pelos alunos. No primeiro grupo destacamos o desenvolvimento de várias práticas: "viagem aos planetas" (construímos o "foguete", os planetas em escala, contamos história e redigimos texto de orientação para os professores); "gnômon humano" (os próprios corpos dos alunos são usados para registrar o movimento aparente do Sol); "crateras da Lua" (concretização de "meteoritos" e "solo lunar" de gesso e exploração da relação entre energia cinética do bólido e tamanho da cratera formada); etc. No segundo grupo, produções de desenhos e redações e discussões dos alunos após a realização de cada prática, revelam que estas têm se mostrado muito eficientes, tanto para estimular a imaginação e a fantasia dos envolvidos, como para trabalhar-se habilidades, competências e conteúdos relacionados à astronomia, segundo uma perspectiva interdisciplinar contextualizada. (PPGECNM/UFRN; NUPA/USP; Temáticos/FAPESP)

  4. Correlated magnetic resonance imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis

    PubMed Central

    Breckwoldt, Michael O; Bode, Julia; Kurz, Felix T; Hoffmann, Angelika; Ochs, Katharina; Ott, Martina; Deumelandt, Katrin; Krüwel, Thomas; Schwarz, Daniel; Fischer, Manuel; Helluy, Xavier; Milford, David; Kirschbaum, Klara; Solecki, Gergely; Chiblak, Sara; Abdollahi, Amir; Winkler, Frank; Wick, Wolfgang; Platten, Michael; Heiland, Sabine; Bendszus, Martin; Tews, Björn

    2016-01-01

    Neoangiogenesis is a pivotal therapeutic target in glioblastoma. Tumor monitoring requires imaging methods to assess treatment effects and disease progression. Until now mapping of the tumor vasculature has been difficult. We have developed a combined magnetic resonance and optical toolkit to study neoangiogenesis in glioma models. We use in vivo magnetic resonance imaging (MRI) and correlative ultramicroscopy (UM) of ex vivo cleared whole brains to track neovascularization. T2* imaging allows the identification of single vessels in glioma development and the quantification of neovessels over time. Pharmacological VEGF inhibition leads to partial vascular normalization with decreased vessel caliber, density, and permeability. To further resolve the tumor microvasculature, we performed correlated UM of fluorescently labeled microvessels in cleared brains. UM resolved typical features of neoangiogenesis and tumor cell invasion with a spatial resolution of ~5 µm. MR-UM can be used as a platform for three-dimensional mapping and high-resolution quantification of tumor angiogenesis. DOI: http://dx.doi.org/10.7554/eLife.11712.001 PMID:26830460

  5. "Uh," "Um," and Autism: Filler Disfluencies as Pragmatic Markers in Adolescents with Optimal Outcomes from Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Irvine, Christina A.; Eigsti, Inge-Marie; Fein, Deborah A.

    2016-01-01

    Filler disfluencies--"uh" and "um"--are thought to serve distinct discourse functions. We examined fillers in spontaneous speech by youth with autism spectrum disorder (ASD), who struggle with pragmatic language, and by youth with ASD who have achieved an "optimal outcome" (OO), as well as in peers with typical…

  6. "Um, I Can Tell You're Lying": Linguistic Markers of Deception versus Truth-Telling in Speech

    ERIC Educational Resources Information Center

    Arciuli, Joanne; Mallard, David; Villar, Gina

    2010-01-01

    Lying is a deliberate attempt to transmit messages that mislead others. Analysis of language behaviors holds great promise as an objective method of detecting deception. The current study reports on the frequency of use and acoustic nature of "um" and "like" during laboratory-elicited lying versus truth-telling. Results obtained using a…

  7. Microwave-Assisted Extraction, Chemical Structures, and Chain Conformation of Polysaccharides from a Novel Cordyceps Sinensis Fungus UM01.

    PubMed

    Cheong, Kit-Leong; Wang, Lan-Ying; Wu, Ding-Tao; Hu, De-Jun; Zhao, Jing; Li, Shao-Ping

    2016-09-01

    Cordyceps sinensis is a well-known tonic food with broad medicinal properties. The aim of the present study was to investigate the optimization of microwave-assisted extraction (MAE) and characterize chemical structures and chain conformation of polysaccharides from a novel C. sinensis fungus UM01. Ion-exchange and gel filtration chromatography were used to purify the polysaccharides. The chemical structure of purified polysaccharide was determined through gas chromatography-mass spectrometry. Moreover, high performance size exclusion chromatography combined with refractive index detector and multiangle laser light scattering were conducted to analyze the molecular weight (Mw ) and chain conformation of purified polysaccharide. Based on the orthogonal design L9 , optimal MAE conditions could be obtained through 1300 W of microwave power, with a 5-min irradiation time at a solid to water ratio of 1:60, generating the highest extraction yield of 6.20%. Subsequently, the polysaccharide UM01-S1 was purified. The UM01-S1 is a glucan-type polysaccharide with a (1→4)-β-d-glucosyl backbone and branching points located at O-3 of Glcp with a terminal-d-Glcp. The Mw , radius of gyration (Rg ) and hydrodynamic radius (Rh ) of UM01-S1 were determined as 5.442 × 10(6)  Da, 21.8 and 20.2 nm, respectively. Using the polymer solution theory, the exponent (ν) value of the power law function was calculated as 0.38, and the shape factor (ρ = Rg /Rh ) was 1.079, indicating that UM01-S1 has a sphere-like conformation with a branched structure in an aqueous solution. These results provide fundamental information for the future application of polysaccharides from cultured C. sinensis in health and functional food area. PMID:27514485

  8. Ford/BASF/UM Activities in Support of the Hydrogen Storage Engineering Center of Excellence

    SciTech Connect

    Veenstra, Mike; Purewal, Justin; Xu, Chunchuan; Yang, Jun; Blaser, Rachel; Sudik, Andrea; Siegel, Don; Ming, Yang; Liu, Dong'an; Chi, Hang; Gaab, Manuela; Arnold, Lena; Muller, Ulrich

    2015-06-30

    Widespread adoption of hydrogen as a vehicular fuel depends critically on the development of low-cost, on-board hydrogen storage technologies capable of achieving high energy densities and fast kinetics for hydrogen uptake and release. As present-day technologies -- which rely on physical storage methods such as compressed hydrogen -- are incapable of attaining established Department of Energy (DOE) targets, development of materials-based approaches for storing hydrogen have garnered increasing attention. Material-based storage technologies have potential to store hydrogen beyond twice the density of liquid hydrogen. To hasten development of these ‘hydride’ materials, the DOE previously established three centers of excellence for materials storage R&D associated with the key classes of materials: metal hydrides, chemical hydrogen, and adsorbents. While these centers made progress in identifying new storage materials, the challenges associated with the engineering of the system around a candidate storage material are in need of further advancement. In 2009 the DOE established the Hydrogen Storage Engineering Center of Excellence with the objective of developing innovative engineering concepts for materials-based hydrogen storage systems. As a partner in the Hydrogen Storage Engineering Center of Excellence, the Ford-UM-BASF team conducted a multi-faceted research program that addresses key engineering challenges associated with the development of materials-based hydrogen storage systems. First, we developed a novel framework that allowed for a material-based hydrogen storage system to be modeled and operated within a virtual fuel cell vehicle. This effort resulted in the ability to assess dynamic operating parameters and interactions between the storage system and fuel cell power plant, including the evaluation of performance throughout various drive cycles. Second, we engaged in cost modeling of various incarnations of the storage systems. This analysis

  9. Origin and characteristics of yardangs in the Um Al-Rimam depressions (N Kuwait)

    NASA Astrophysics Data System (ADS)

    Al-Dousari, Ali. M.; Al-Elaj, Maraheb; Al-Enezi, Eqbal; Al-Shareeda, Abdulaziz

    2009-03-01

    Although Arabia hosts one of the largest deserts in the world, studies regarding aeolian erosional features in general and yardangs in particular are rare. The principal aim of this study is to delineate and investigate the various forms of yardangs in the Um Al-Rimam depressions in the northern part of Kuwait. The study area consists of two main depressions connected by neck area made up of continental sediments. Both depressions are surrounded by a dissected escarpment and their floors host muddy playas. On lithological bases, three main types of yardang have been identified: 7 yardangs are sculptured in sandstones of Lower Fars Formation (Lower to Middle Miocene), 23 are carved in calcretic rocks of Ghar Formation (Oligocene to Lower Miocene), and 11 yardangs are developed in Quaternary sediments. Their mean orientation NW (297°) coincides with the prevailing direction of the strong local northwesterly wind called the shamal. The average length/width ratio is 1.5:1. The wide geographic distribution of yardangs around the margins of the northern depression is due to sand blasting. This is explained by the annual sand accumulation measured in the study area where the northern depression shows 143 times higher accumulation than the southern depression, the neck area and the platform above the depressions. Also, the field measurements for annual erosional rates show that the sides of the yardangs are more affected by erosion compared to their middle parts. Remarkably slight mineralogical variations were detected within the surface sediments of Um Al-Rimam depressions and the Quaternary muddy yardangs which indicate a common origin. The age of yardangs is unknown but annual erosional rates on a small Quaternary muddy yardang suggest that they range in age between 44 and 1500 years depending on yardang size. It is believed, as indicated from field observation and interpretation of aerial photos, that the majority of yardangs are pre-existing bedrock forms. These

  10. Estimation of broadband emissivity (8-12 um) from ASTER data by using RM-NN.

    PubMed

    Mao, K B; Ma, Y; Shen, X Y; Li, B P; Li, C Y; Li, Z L

    2012-08-27

    Land surface window emissivity is a key parameter for estimating the longwave radiative budget. The combined radiative transfer model (RM) with neural network (NN) algorithm is utilized to directly estimate the window (8-12 um) emissivity from the brightness temperature of the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) with 90 m spatial resolution. Although the estimation accuracy is very high when the broadband emissivity is estimated from AST05 (ASTER Standard Data Product) by using regression method, the accuracy of AST05 is about ± 0.015 for 86 spectra which is determined by the atmosphere correction for ASTER 1B data. The MODTRAN 4 is used to simulate the process of radiance transfer, and the broadband emissivity is directly estimated from the brightness temperature of ASTER 1B data at satellite. The comparison analysis indicates that the RM-NN is more competent to estimate broadband emissivity than other method when the brightness temperatures of band 11, 12, 13, 14 are made as input nodes of dynamic neural network. The estimation average accuracy is about 0.009, and the estimation results are not sensitive to instrument noise. The RM-NN is applied to extract broadband emissivity from an image of ASTER 1B data in China, and the comparison against a classification based multiple bands with 15 m spatial resolution shows that the estimation results from RM-NN are very good. PMID:23037062

  11. Evaluation of natural radionuclides at Um-Greifat area, eastern desert of Egypt.

    PubMed

    Nada, A

    2003-02-01

    Air borne radiometric maps and remote sensing techniques were used to explore for the occurrence of radioactive materials. The previous techniques recorded radioactive mineralization for the first time along the NW-SE trending fault zones within the Miocene clastic-carbonate sediments. In the present study, gamma-ray spectrometry was used to confirm the presence of this mineralization. Concentrations of radionuclides, associated within the iron ochre at Um-Greifat area, have been measured, using a hyper-pure germanium spectrometer. The variation in concentration of radionuclides for the area under investigation can be classified into A, B and C regions of high, medium and low natural radioactivity. In region A, average concentration in Bqkg(-1) has been observed to range from 1858 to 4062 for 238U, between 29 and 151 for 232Th, from 60 to 136 for 235U and between 46 and 409 Bqkg(-1) for 40K. Radium equivalent activities (Ra(eq)) in addition to external and internal hazard indices (H(ex), H(in)) have also been determined. Ra(eq) varies between 1901 and 4307Bqkg(-1), which exceeds the permitted value (370Bqkg(-1)) and H(ex) and H(in) are higher than 1. The high activity concentration within region A points to an environmental hazard, while regions B and C have less exposure effect on human beings. PMID:12573328

  12. An evaluation of China's water cycle in the MetUM-GC2 coupled model

    NASA Astrophysics Data System (ADS)

    Rodriguez, Jose; Marzin, Charline

    2015-04-01

    There is a general consensus in climate projections that the global hydrological cycle is likely to experience significant changes in the future, in response to increased concentrations of greenhouse gases. At the regional scale, model simulations show large variations in the predictions of changes in the components of the water cycle. Increasing confidence in regional prediction of the water cycle is at the top of the NWP and climate research agenda, requiring a comprehensive evaluation of the physical processes which may play an important role. Here we present preliminary results of an evaluation of the capacity of the MetUM-GC2 coupled model to reproduce the characteristics of the water cycle in the region of China. Using water budget techniques in the atmospheric and terrestrial branches we test the water cycle components and the model's ability to replicate the climatological annual cycle and its interannual variability. Recent drought and flood events are evaluated and various metrics are employed to compare the role played by the atmospheric general circulation including the boreal summer and winter monsoon regimes and soil moisture feedback in model and observations.

  13. VizieR Online Data Catalog: [NII]205um emission in local luminous IR galaxies (Zhao+, 2016)

    NASA Astrophysics Data System (ADS)

    Zhao, Y.; Lu, N.; Xu, C. K.; Gao, Y.; Lord, S. D.; Charmandaris, V.; Diaz-Santos, T.; Evans, A.; Howell, J.; Petric, A. O.; van der Werf, P. P.; Sanders, D. B.

    2016-05-01

    The primary sample studied in this paper is from the Herschel open time project Herschel Spectroscopic Survey of Warm Molecular Gas in Local Luminous Infrared Galaxies (OT1nlu1; PI: N. Lu). The observations were conducted with the Herschel SPIRE/FTS in its point source spectroscopy mode and high spectral resolution configuration, yielding a spectral resolution of 0.04/cm (or 1.2GHz) over the spectral coverage of 194-672um. (1 data file).

  14. UM 625 REVISITED: MULTIWAVELENGTH STUDY OF A SEYFERT 1 GALAXY WITH A LOW-MASS BLACK HOLE

    SciTech Connect

    Jiang Ning; Dong Xiaobo; Yang Huan; Wang Junxian; Ho, Luis C. E-mail: xbdong@ustc.edu.cn

    2013-06-10

    UM 625, previously identified as a narrow-line active galactic nucleus (AGN), actually exhibits broad H{alpha} and H{beta} lines whose width and luminosity indicate a low black hole (BH) mass of 1.6 Multiplication-Sign 10{sup 6} M{sub Sun }. We present a detailed multiwavelength study of the nuclear and host galaxy properties of UM 625. Analysis of Chandra and XMM-Newton observations suggests that this system contains a heavily absorbed and intrinsically X-ray weak ({alpha}{sub ox} = -1.72) nucleus. Although not strong enough to qualify as radio loud, UM 625 does belong to a minority of low-mass AGNs detected in the radio. The broadband spectral energy distribution constrains the bolometric luminosity to L{sub bol} Almost-Equal-To (0.5-3) Multiplication-Sign 10{sup 43} erg s{sup -1} and L{sub bol}/L{sub Edd} Almost-Equal-To 0.02-0.15. A comprehensive analysis of Sloan Digital Sky Survey and Hubble Space Telescope images shows that UM 625 is a nearly face-on S0 galaxy with a prominent, relatively blue pseudobulge (Sersic index n = 1.60) that accounts for {approx}60% of the total light in the R band. The extended disk is featureless, but the central {approx}150-400 pc contains a conspicuous semi-ring of bright, blue star-forming knots, whose integrated ultraviolet luminosity suggests a star formation rate of {approx}0.3 M{sub Sun} yr{sup -1}. The mass of the central BH roughly agrees with the value predicted from its bulge velocity dispersion but is significantly lower than that expected from its bulge luminosity.

  15. VizieR Online Data Catalog: ALMA 870um obs. of HerMES galaxies (Bussmann+, 2015)

    NASA Astrophysics Data System (ADS)

    Bussmann, R. S.; Riechers, D.; Fialkov, A.; Scudder, J.; Hayward, C. C.; Cowley, W. I.; Bock, J.; Calanog, J.; Chapman, S. C.; Cooray, A.; de Bernardis, F.; Farrah, D.; Fu, H.; Gavazzi, R.; Hopwood, R.; Ivison, R. J.; Jarvis, M.; Lacey, C.; Loeb, A.; Oliver, S. J.; Perez-Fournon, I.; Rigopoulou, D.; Roseboom, I. G.; Scott, D.; Smith, A. J.; Vieira, J. D.; Wang, L.; Wardlow, J.

    2016-02-01

    ALMA 870um data were obtained during Cycle 0 from 2012 June to December (Program 2011.0.00539.S; PI: D. Riechers). Optical imaging observations (ugriz) using the Gemini Multi-Object Spectrograph-South (GMOS-S) were conducted in queue mode during the 2013B semester as part of program GS-2013B-Q-77 (PI: R. S. Bussmann). (3 data files).

  16. Genome Anatomy of Pyrenochaeta unguis-hominis UM 256, a Multidrug Resistant Strain Isolated from Skin Scraping.

    PubMed

    Toh, Yue Fen; Yew, Su Mei; Chan, Chai Ling; Na, Shiang Ling; Lee, Kok Wei; Hoh, Chee-Choong; Yee, Wai-Yan; Ng, Kee Peng; Kuan, Chee Sian

    2016-01-01

    Pyrenochaeta unguis-hominis is a rare human pathogen that causes infection in human skin and nail. P. unguis-hominis has received little attention, and thus, the basic biology and pathogenicity of this fungus is not fully understood. In this study, we performed in-depth analysis of the P. unguis-hominis UM 256 genome that was isolated from the skin scraping of a dermatitis patient. The isolate was identified to species level using a comprehensive multilocus phylogenetic analysis of the genus Pyrenochaeta. The assembled UM 256 genome has a size of 35.5 Mb and encodes 12,545 putative genes, and 0.34% of the assembled genome is predicted transposable elements. Its genomic features propose that the fungus is a heterothallic fungus that encodes a wide array of plant cell wall degrading enzymes, peptidases, and secondary metabolite biosynthetic enzymes. Antifungal drug resistance genes including MDR, CDR, and ERG11/CYP51 were identified in P. unguis-hominis UM 256, which may confer resistance to this fungus. The genome analysis of P. unguis-hominis provides an insight into molecular and genetic basis of the fungal lifestyles, understanding the unrevealed biology of antifungal resistance in this fungus. PMID:27626635

  17. UM-SCC-104: a new human papillomavirus-16 containing head and neck squamous cell carcinoma cell line

    PubMed Central

    Tang, Alice L.; Davis, Samantha J.; Owen, John H.; Graham, Martin P.; Czerwinski, Michael J.; Park, Jung Je; Walline, Heather; Stoerker, Jay; McHugh, Jonathan B.; Chepeha, Douglas; Bradford, Carol R.; Carey, Thomas E.; Prince, Mark E.

    2012-01-01

    BACKGROUND Few human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) cell lines exist. We established UM-SCC-104, a new HPV(+) HNSCC cell linefrom a recurrent oral cavity tumor, and characterized it for the presence of cancer stem cells (CSC). METHODS Tumor cells were tested for biomarker expression by immunohistology and the presence of HPV was assessed by several methods. RESULTS UM-SCC-104 has a unique genotype, contains HPV-16 and expresses E6/E7. Inoculation of (Aldehyde Dehydrogenase) ALDH(+) and ALDH(−) cells in an immunocompromised mouse resulted in tumor growth from the ALDH(+) cells after 6 weeks that recapitulated the histology of the primary, while ALDH(−) cells did not produce tumors. CONCLUSIONS UM-SCC-104, a new HPV-16, CSC-containing HNSCC cell line will aid in studying recurrent HPV(+) tumors. The aggressive nature of this tumor is consistent with high uniform expression of EGFR and a functionally significant proportion of ALDH(+) CSC. PMID:22162267

  18. Design, fabrication and testing of 17um pitch 640x480 uncooled infrared focal plane array detector

    NASA Astrophysics Data System (ADS)

    Jiang, Lijun; Liu, Haitao; Chi, Jiguang; Qian, Liangshan; Pan, Feng; Liu, Xiang

    2015-10-01

    Uncooled infrared focal plane array (UIRFPA) detectors are widely used in industrial thermography cameras, night vision goggles, thermal weapon sights, as well as automotive night vision systems. To meet the market requirement for smaller pixel pitch and higher resolution, we have developed a 17um pitch 640x480 UIRFPA detector. The detector is based on amorphous silicon (a-Si) microbolometer technology, the readout integrated circuit (ROIC) is designed and manufactured with 0.35um standard CMOS technology on 8 inch wafer, the microbolometer is fabricated monolithically on the ROIC using an unique surface micromachining process developed inside the company, the fabricated detector is vacuum packaged with hermetic metal package and tested. In this paper we present the design, fabrication and testing of the 17um 640x480 detector. The design trade-off of the detector ROIC and pixel micro-bridge structure will be discussed, by comparison the calculation and simulation to the testing results. The novel surface micromachining process using silicon sacrificial layer will be presented, which is more compatible with the CMOS process than the traditional process with polyimide sacrificial layer, and resulted in good processing stability and high fabrication yield. The performance of the detector is tested, with temperature equivalent temperature difference (NETD) less than 60mK at F/1 aperture, operability better than 99.5%. The results demonstrate that the detector can meet the requirements of most thermography and night vision applications.

  19. Project UM-HAUL: A self-unloading reusable lunar lander

    NASA Astrophysics Data System (ADS)

    The establishment of a lunar base is technologically and financially challenging. Given the necessary resources and political support, it can be done. In addition to the geopolitical obstacles, however, there are logistical problems involved in establishing such bases that can only be overcome with the acquisition of a significant transportation and communications network in the Earth-Moon spatial region. Considering the significant number of payloads that will be required in this process, the mass-specific cost of launching these payloads, and the added risk and cost of human presence in space, it is clearly desirable to automate major parts of such an operation. One very costly and time-consuming factor in this picture is the delivery of payloads to the Moon. Foreseeable payloads would include atmospheric modules, inflatable habitat kits, energy and oxygen plant elements, ground vehicles, laboratory modules, crew supplies, etc. The duration of high-risk human presence on the Moon could be greatly reduced if all such payloads were delivered to the prospective base site in advance of crew arrival. In this view, the idea of a 'Self-Unloading Reusable Lunar Lander' (SURLL) arises naturally. The general scenario depicts the lander being brought to low lunar orbit (LLO) from Earth atop a generic Orbital Transfer Vehicle (OTV). From LLO, the lander shuttles payloads down to the lunar surface, where, by means of some resident, detachable unloading device, it deploys the payloads and returns to orbit. The general goal is for the system to perform with maximum payload capability, automation, and reliability, while also minimizing environmental hazards, servicing needs, and mission costs. Our response to this demand is UM-HAUL, or the UnManned Heavy pAyload Unloader and Lander. The complete study includes a system description, along with a preliminary cost analysis and a design status assessment.

  20. OV-Wav: um novo pacote para análise multiescalar em astronomia

    NASA Astrophysics Data System (ADS)

    Pereira, D. N. E.; Rabaça, C. R.

    2003-08-01

    Wavelets e outras formas de análise multiescalar têm sido amplamente empregadas em diversas áreas do conhecimento, sendo reconhecidamente superiores a técnicas mais tradicionais, como as análises de Fourier e de Gabor, em certas aplicações. Embora a teoria dos wavelets tenha começado a ser elaborada há quase trinta anos, seu impacto no estudo de imagens astronômicas tem sido pequeno até bem recentemente. Apresentamos um conjunto de programas desenvolvidos ao longo dos últimos três anos no Observatório do Valongo/UFRJ que possibilitam aplicar essa poderosa ferramenta a problemas comuns em astronomia, como a remoção de ruído, a detecção hierárquica de fontes e a modelagem de objetos com perfis de brilho arbitrários em condições não ideais. Este pacote, desenvolvido para execução em plataforma IDL, teve sua primeira versão concluída recentemente e está sendo disponibilizado à comunidade científica de forma aberta. Mostramos também resultados de testes controlados ao quais submetemos os programas, com a sua aplicação a imagens artificiais, com resultados satisfatórios. Algumas aplicações astrofísicas foram estudadas com o uso do pacote, em caráter experimental, incluindo a análise da componente de luz difusa em grupos compactos de galáxias de Hickson e o estudo de subestruturas de nebulosas planetárias no espaço multiescalar.

  1. The response of chemistry and climate to the 11-year solar cycle in UM-UKCA

    NASA Astrophysics Data System (ADS)

    Bednarz, Ewa; Telford, Paul; Maycock, Amanda; Abraham, Luke; Braesicke, Peter; Pyle, John

    2014-05-01

    It is now generally agreed that the UV variability associated with the 11-year solar cycle leads to changes in ozone and temperature in the upper stratosphere. In addition, a range of observational and modelling studies suggest that such changes are the starting point for a chain of processes (including feedbacks) resulting in circulation changes in many areas of the atmosphere. However, precise details of the interactions between chemistry and meteorology induced by solar variability remain under question. In our study, we use a version of the UM-UKCA chemistry-climate model with consistent spectrally-resolved solar variability. While the solar cycle in heating rates has been applied with the method used in HadGEM2-ES, fine spectrally-resolved solar variability has been uniquely incorporated into the Fast-JX photolysis scheme. We perform two 50-year-long perpetual year solar maximum and solar minimum integrations and complement them with a three member ensemble of a transient 1960-2010 integration in which boundary conditions correspond by and large to the CCMI Ref-C1 scenario. We show how the inferred solar signals vary between the individual experiments. This indicates high natural variability and the resulting contamination of the solar signal with contributions from other processes as well as the existence of possible non-linearities between the solar cycle and other atmospheric forcings. Therefore, we highlight that long data series are needed to ensure correct attribution of the modelled and observed anomalies. In addition, we present results from two perpetual year experiments in which the solar cycle was applied exclusively in either short-wave heating or photolysis. We find large non-linearities in the modelled anomalies as compared to the realistic integration with both modulations included. This highlights the subtle nature of the dynamical response to the solar cycle forcing and indicates the need for interactive chemistry with a detailed photolysis

  2. Project UM-HAUL: A self-unloading reusable lunar lander

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The establishment of a lunar base is technologically and financially challenging. Given the necessary resources and political support, it can be done. In addition to the geopolitical obstacles, however, there are logistical problems involved in establishing such bases that can only be overcome with the acquisition of a significant transportation and communications network in the Earth-Moon spatial region. Considering the significant number of payloads that will be required in this process, the mass-specific cost of launching these payloads, and the added risk and cost of human presence in space, it is clearly desirable to automate major parts of such an operation. One very costly and time-consuming factor in this picture is the delivery of payloads to the Moon. Foreseeable payloads would include atmospheric modules, inflatable habitat kits, energy and oxygen plant elements, ground vehicles, laboratory modules, crew supplies, etc. The duration of high-risk human presence on the Moon could be greatly reduced if all such payloads were delivered to the prospective base site in advance of crew arrival. In this view, the idea of a 'Self-Unloading Reusable Lunar Lander' (SURLL) arises naturally. The general scenario depicts the lander being brought to low lunar orbit (LLO) from Earth atop a generic Orbital Transfer Vehicle (OTV). From LLO, the lander shuttles payloads down to the lunar surface, where, by means of some resident, detachable unloading device, it deploys the payloads and returns to orbit. The general goal is for the system to perform with maximum payload capability, automation, and reliability, while also minimizing environmental hazards, servicing needs, and mission costs. Our response to this demand is UM-HAUL, or the UnManned Heavy pAyload Unloader and Lander. The complete study includes a system description, along with a preliminary cost analysis and a design status assessment.

  3. NE VIII lambda 774 and time variable associated absorption in the QSO UM 675

    NASA Technical Reports Server (NTRS)

    Hamann, Fred; Barlow, Thomas A.; Beaver, E. A.; Burbidge, E. M.; Cohen, Ross D.; Junkkarinen, Vesa; Lyons, R.

    1995-01-01

    We discuss measurements of Ne VIII lambda 774 absorption and the time variability of other lines in the z(sub a) approximately equal z(sub e) absorption system of the z(sub e) = 2.15 QSO UM 675 (0150-203). The C IV lambda 1549 and N V 1240 doublets at z(sub a) = 2.1340 (shifted approximately 1500 km/s from z(sub e) strengthened by a factor of approximately 3 between observations by Sargent, Boksenberg and Steidel (1981 November) and our earliest measurements (1990 November and December). We have no information on changes in other z(sub a) approximately equal z(sub e) absorption lines. Continued monitoring since 1990 November shows no clear changes in any of the absorptions between approximately 1100 and 1640 A rest. The short timescale of the variability (less than or approximately equal to 2.9 yr rest) strongly suggests that the clouds are dense, compact, close to the QSO, and photoionized by the QSO continuum. If the line variability is caused by changes in the ionization, the timescale requires densities greater than approximately 4000/cu cm. Photoionization calculations place the absorbing clouds within approximately 200 pc of the continuum source. The full range of line ionizations (from Ne VIII lambda 774 to C III lambda 977) in optically thin gas (no Lyman limit) implies that the absorbing regions span a factor of more than approximately 10 in distance or approximately 100 in density. Across these regions, the total hydrogen (H I + H II) column ranges from a few times 10(exp 18)/sq cm in the low-ionization gas to approximately 10(exp 20)/sq cm where the Ne VIII doublet forms. The metallicity is roughly solar or higher, with nitrogen possibly more enhanced by factors of a few. The clouds might contribute significant line emission if they nearly envelop the QSO. The presence of highly ionized Ne VIII lambda 774 absorption near the QSO supports recent studies that link z(sub a) approximately equal to z(sub e) systems with X-ray 'wamr absorbers. We show that the

  4. BSSDATA - um programa otimizado para filtragem de dados em radioastronomia solar

    NASA Astrophysics Data System (ADS)

    Martinon, A. R. F.; Sawant, H. S.; Fernandes, F. C. R.; Stephany, S.; Preto, A. J.; Dobrowolski, K. M.

    2003-08-01

    A partir de 1998, entrou em operação regular no INPE, em São José dos Campos, o Brazilian Solar Spectroscope (BSS). O BSS é dedicado às observações de explosões solares decimétricas com alta resolução temporal e espectral, com a principal finalidade de investigar fenômenos associados com a liberação de energia dos "flares" solares. Entre os anos de 1999 e 2002, foram catalogadas, aproximadamente 340 explosões solares classificadas em 8 tipos distintos, de acordo com suas características morfológicas. Na análise detalhada de cada tipo, ou grupo, de explosões solares deve-se considerar a variação do fluxo do sol calmo ("background"), em função da freqüência e a variação temporal, além da complexidade das explosões e estruturas finas registradas superpostas ao fundo variável. Com o intuito de realizar tal análise foi desenvolvido o programa BSSData. Este programa, desenvolvido em linguagem C++, é constituído de várias ferramentas que auxiliam no tratamento e análise dos dados registrados pelo BSS. Neste trabalho iremos abordar as ferramentas referentes à filtragem do ruído de fundo. As rotinas do BSSData para filtragem de ruído foram testadas nos diversos grupos de explosões solares ("dots", "fibra", "lace", "patch", "spikes", "tipo III" e "zebra") alcançando um bom resultado na diminuição do ruído de fundo e obtendo, em conseqüência, dados onde o sinal torna-se mais homogêneo ressaltando as áreas onde existem explosões solares e tornando mais precisas as determinações dos parâmetros observacionais de cada explosão. Estes resultados serão apresentados e discutidos.

  5. Microwave window breakdown experiments and simulations on the UM/L-3 relativistic magnetron.

    PubMed

    Hoff, B W; Mardahl, P J; Gilgenbach, R M; Haworth, M D; French, D M; Lau, Y Y; Franzi, M

    2009-09-01

    Experiments have been performed on the UM/L-3 (6-vane, L-band) relativistic magnetron to test a new microwave window configuration designed to limit vacuum side breakdown. In the baseline case, acrylic microwave windows were mounted between three of the waveguide coupling cavities in the anode block vacuum housing and the output waveguides. Each of the six 3 cm deep coupling cavities is separated from its corresponding anode cavity by a 1.75 cm wide aperture. In the baseline case, vacuum side window breakdown was observed to initiate at single waveguide output powers close to 20 MW. In the new window configuration, three Air Force Research Laboratory-designed, vacuum-rated directional coupler waveguide segments were mounted between the coupling cavities and the microwave windows. The inclusion of the vacuum side power couplers moved the microwave windows an additional 30 cm away from the anode apertures. Additionally, the Lucite microwave windows were replaced with polycarbonate windows and the microwave window mounts were redesigned to better maintain waveguide continuity in the region around the microwave windows. No vacuum side window breakdown was observed in the new window configuration at single waveguide output powers of 120+MW (a factor of 3 increase in measured microwave pulse duration and factor of 3 increase in measured peak power over the baseline case). Simulations were performed to investigate likely causes for the window breakdown in the original configuration. Results from these simulations have shown that in the original configuration, at typical operating voltage and magnetic field ranges, electrons emitted from the anode block microwave apertures strike the windows with a mean kinetic energy of 33 keV with a standard deviation of 14 keV. Calculations performed using electron impact angle and energy data predict a first generation secondary electron yield of 65% of the primary electron population. The effects of the primary aperture electron

  6. Community structure and activity of a highly dynamic and nutrient-limited hypersaline microbial mat in Um Alhool Sabkha, Qatar.

    PubMed

    Al-Thani, Roda; Al-Najjar, Mohammad A A; Al-Raei, Abdul Munem; Ferdelman, Tim; Thang, Nguyen M; Al Shaikh, Ismail; Al-Ansi, Mehsin; de Beer, Dirk

    2014-01-01

    The Um Alhool area in Qatar is a dynamic evaporative ecosystem that receives seawater from below as it is surrounded by sand dunes. We investigated the chemical composition, the microbial activity and biodiversity of the four main layers (L1-L4) in the photosynthetic mats. Chlorophyll a (Chl a) concentration and distribution (measured by HPLC and hyperspectral imaging, respectively), the phycocyanin distribution (scanned with hyperspectral imaging), oxygenic photosynthesis (determined by microsensor), and the abundance of photosynthetic microorganisms (from 16S and 18S rRNA sequencing) decreased with depth in the euphotic layer (L1). Incident irradiance exponentially attenuated in the same zone reaching 1% at 1.7-mm depth. Proteobacteria dominated all layers of the mat (24%-42% of the identified bacteria). Anoxygenic photosynthetic bacteria (dominated by Chloroflexus) were most abundant in the third red layer of the mat (L3), evidenced by the spectral signature of Bacteriochlorophyll as well as by sequencing. The deep, black layer (L4) was dominated by sulfate reducing bacteria belonging to the Deltaproteobacteria, which were responsible for high sulfate reduction rates (measured using 35S tracer). Members of Halobacteria were the dominant Archaea in all layers of the mat (92%-97%), whereas Nematodes were the main Eukaryotes (up to 87%). Primary productivity rates of Um Alhool mat were similar to those of other hypersaline microbial mats. However, sulfate reduction rates were relatively low, indicating that oxygenic respiration contributes more to organic material degradation than sulfate reduction, because of bioturbation. Although Um Alhool hypersaline mat is a nutrient-limited ecosystem, it is interestingly dynamic and phylogenetically highly diverse. All its components work in a highly efficient and synchronized way to compensate for the lack of nutrient supply provided during regular inundation periods. PMID:24658360

  7. Community Structure and Activity of a Highly Dynamic and Nutrient-Limited Hypersaline Microbial Mat in Um Alhool Sabkha, Qatar

    PubMed Central

    Al-Thani, Roda; Al-Najjar, Mohammad A. A.; Al-Raei, Abdul Munem; Ferdelman, Tim; Thang, Nguyen M.; Shaikh, Ismail Al; Al-Ansi, Mehsin; de Beer, Dirk

    2014-01-01

    The Um Alhool area in Qatar is a dynamic evaporative ecosystem that receives seawater from below as it is surrounded by sand dunes. We investigated the chemical composition, the microbial activity and biodiversity of the four main layers (L1–L4) in the photosynthetic mats. Chlorophyll a (Chl a) concentration and distribution (measured by HPLC and hyperspectral imaging, respectively), the phycocyanin distribution (scanned with hyperspectral imaging), oxygenic photosynthesis (determined by microsensor), and the abundance of photosynthetic microorganisms (from 16S and 18S rRNA sequencing) decreased with depth in the euphotic layer (L1). Incident irradiance exponentially attenuated in the same zone reaching 1% at 1.7-mm depth. Proteobacteria dominated all layers of the mat (24%–42% of the identified bacteria). Anoxygenic photosynthetic bacteria (dominated by Chloroflexus) were most abundant in the third red layer of the mat (L3), evidenced by the spectral signature of Bacteriochlorophyll as well as by sequencing. The deep, black layer (L4) was dominated by sulfate reducing bacteria belonging to the Deltaproteobacteria, which were responsible for high sulfate reduction rates (measured using 35S tracer). Members of Halobacteria were the dominant Archaea in all layers of the mat (92%–97%), whereas Nematodes were the main Eukaryotes (up to 87%). Primary productivity rates of Um Alhool mat were similar to those of other hypersaline microbial mats. However, sulfate reduction rates were relatively low, indicating that oxygenic respiration contributes more to organic material degradation than sulfate reduction, because of bioturbation. Although Um Alhool hypersaline mat is a nutrient-limited ecosystem, it is interestingly dynamic and phylogenetically highly diverse. All its components work in a highly efficient and synchronized way to compensate for the lack of nutrient supply provided during regular inundation periods. PMID:24658360

  8. Um enfoque antropológico para o ensino de astronomia no nível médio

    NASA Astrophysics Data System (ADS)

    Costa, G. B.; Jafelice, L. C.

    2003-08-01

    Há uma enorme carência de materiais didático-pedagógicos em astronomia para professores do ensino médio, sobretudo materiais que explorem também aspectos humanísticos. A origem do Universo é um bom exemplo desta constatação central. Embora tal origem teve explicações culturais diversas, os professores não têm informações sobre isso e muito menos material que trabalhe diferentes visões de mundo e treinamento que os capacite a abordá-las devidamente. Conseqüentemente o ensino de astronomia costuma ser tecnicista e dissociado do aspecto humano que alimenta o grande interesse e curiosidade que esses temas despertam. Aqui apresentamos propostas visando contribuir para reverter esse quadro e trabalhamos distintas visões de Universo: espontâneas, autóctones e científicas. Desenvolvemos práticas, materiais instrucionais e textos para viabilizar a adoção de um enfoque antropológico para o ensino de astronomia no nível médio, no qual as culturas humanística e científica sejam integradas de uma maneira contextualizada e eficaz para aquele ensino. Estas propostas foram aplicadas em um curso de treinamento para professores da rede pública de diferentes disciplinas. A receptividade dos professores à abordagem proposta e os resultados alcançados foram muito estimulantes. Destes, destacamos: produção de roteiros de atividades; desenvolvimento de práticas didático-pedagógicas específicas (e.g., encenação de mitos; dança primordial guarani; "criação" de constelações e interpretações pluriculturais; etc.); e sugestões concretas para a efetiva realização de um ensino interdisciplinar contextualizado, onde questões cosmogônicas servem de mote para iniciar tal ensino. Discutimos estes resultados e como o enfoque adotado pode instrumentalizar os professores para leituras de mundo que incluem naturalmente aspectos culturais, sociais e históricos associados aos temas estudados. (PPGECNM/UFRN; PRONEX/FINEP; NUPA/USP; Temáticos/FAPESP)

  9. The U. S. Geological Survey, Digital Spectral Library: Version 1 (0.2 to 3.0um)

    USGS Publications Warehouse

    Clark, Roger N.; Swayze, Gregg A.; Gallagher, Andrea J.; King, Trude V.V.; Calvin, Wendy M.

    1993-01-01

    We have developed a digital reflectance spectral library, with management and spectral analysis software. The library includes 498 spectra of 444 samples (some samples include a series of grain sizes) measured from approximately 0.2 to 3.0 um . The spectral resolution (Full Width Half Maximum) of the reflectance data is <= 4 nm in the visible (0.2-0.8 um) and <= 10 nm in the NIR (0.8-2.35 um). All spectra were corrected to absolute reflectance using an NIST Halon standard. Library management software lets users search on parameters (e.g. chemical formulae, chemical analyses, purity of samples, mineral groups, etc.) as well as spectral features. Minerals from borate, carbonate, chloride, element, halide, hydroxide, nitrate, oxide, phosphate, sulfate, sulfide, sulfosalt, and the silicate (cyclosilicate, inosilicate, nesosilicate, phyllosilicate, sorosilicate, and tectosilicate) classes are represented. X-Ray and chemical analyses are tabulated for many of the entries, and all samples have been evaluated for spectral purity. The library also contains end and intermediate members for the olivine, garnet, scapolite, montmorillonite, muscovite, jarosite, and alunite solid-solution series. We have included representative spectra of H2O ice, kerogen, ammonium-bearing minerals, rare-earth oxides, desert varnish coatings, kaolinite crystallinity series, kaolinite-smectite series, zeolite series, and an extensive evaporite series. Because of the importance of vegetation to climate-change studies we have include 17 spectra of tree leaves, bushes, and grasses. The library and software are available as a series of U.S.G.S. Open File reports. PC user software is available to convert the binary data to ascii files (a separate U.S.G.S. open file report). Additionally, a binary data files are on line at the U.S.G.S. in Denver for anonymous ftp to users on the Internet. The library search software enables a user to search on documentation parameters as well as spectral features. The

  10. ON THE COMPACT H II GALAXY UM 408 AS SEEN BY GMOS-IFU: PHYSICAL CONDITIONS

    SciTech Connect

    Lagos, Patricio; Telles, Eduardo; Munoz-Tunon, Casiana; Tenorio-Tagle, Guillermo E-mail: etelles@on.br E-mail: rcarrasco@gemini.edu E-mail: gtt@inaoep.mx

    2009-06-15

    We present Integral Field Unit GMOS-IFU data of the compact H II galaxy UM 408, obtained at the Gemini South telescope, in order to derive the spatial distribution of emission lines and line ratios, kinematics, plasma parameters, and oxygen abundances as well the integrated properties over an area of 3''x4.''4 equivalent with {approx}750 pc x 1100 pc located in the central part of the galaxy. The starburst in this area is resolved into two giant regions of about 1.''5 and 1'' ({approx}375 and {approx}250 pc) diameter, respectively and separated 1.5-2'' ({approx}500 pc). The extinction distribution concentrate its highest values close but not coincident with the maxima of H{alpha} emission around each one of the detected regions. This indicates that the dust has been displaced from the exciting clusters by the action of their stellar winds. The ages of these two regions, estimated using H{beta} equivalent widths, suggest that they are coeval events of {approx}5 Myr with stellar masses of {approx}10{sup 4} M {sub sun}. We have also used [O III]/H{beta} and [S II]/H{alpha} ratio maps to explore the excitation mechanisms in this galaxy. Comparing the data points with theoretical diagnostic models, we found that all of them are consistent with excitation by photoionization by massive stars. The H{alpha} emission line was used to measure the radial velocity and velocity dispersion. The heliocentric radial velocity shows an apparent systemic motion where the east part of the galaxy is blueshifted, while the west part is redshifted, with a relative motion of {approx}10 km s{sup -1}. The velocity dispersion map shows supersonic values typical for extragalactic H II regions. We derived an integrated oxygen abundance of 12+log(O/H) = 7.87 summing over all spaxels in our field of view. An average value of 12+log(O/H) = 7.77 and a difference of {delta}(O/H) = 0.47 between the minimum and maximum values (7.58 {+-} 0.06-8.05 {+-} 0.04) were found, considering all data points

  11. Geochemistry of the Neoproterozoic metasediments of Malhaq and Um Zariq formations, Kid metamorphic complex, Sinai, Egypt: Implications for source-area weathering, provenance, recycling, and depositional tectonic setting

    NASA Astrophysics Data System (ADS)

    El-Bialy, Mohammed Zaky

    2013-08-01

    The Um Zariq and Malhaq formations occupy roughly the northern half of the Kid metamorphic complex of SE Sinai, in the NE part of the Arabian-Nubian Shield. The Um Zariq Formation metasediments are relicts of an old sedimentary sequence (Cryogenian; 813 ± 6 Ma), whereas the Malhaq Formation records several phases of Ediacaran sedimentation and volcanic activity (615-607 Ma). The Um Zariq Formation is mainly represented by well-bedded metapelitic schists, while the Malhaq Formation comprises a series of structureless to schistose felsic to intermediate metavolcanics interbedded with mica-rich phyllites and schists. The Um Zariq metasediments are depleted in SiO2, CaO and K2O and enriched in TiO2, Al2O3 and K2O relative to those of the Malhaq Formation. Aside from the relatively low Ni and Cr concentrations, compatible transition elements of these metasediments are comparable to average crustal contents. Except for marked Sr depletion, LILEs are around average continental crust values. Pronounced negative Nb-Ta anomalies and enrichment of Um Zariq samples in Th, U, Zr, Ti and Y relative to Malhaq ones are the main features of HFSEs. The REE patterns of all samples are parallel to sub-parallel LREE-enriched, with distinct negative Eu anomalies and weakly fractionated HREE segments. The source rocks of the Malhaq Formation metasediments underwent mild to moderate chemical weathering, whereas those of the Um Zariq Formation have suffered severe chemical weathering. These metasediments are predominately derived from felsic to intermediate igneous sources, with a particular slight addition from recycled sedimentary source to the Malhaq Formation metasediments. They are collectively geochemically immature and have suffered minor sedimentary recycling, with the experience of the Malhaq Formation metasediments from higher degree of sorting and reworking. The Malhaq and Um Zariq metasediments were originally deposited in a continental arc setting, most probably back

  12. Quantitation of deposition, clearance and routes of elimination of 3 um insoluble particles in the sheep lung

    SciTech Connect

    Langenback, E.G.

    1984-01-01

    This study is the first to completely determine the number of particles deposited in the lung, the number of particles cleared over a period of a hundred days and the pathways by which the particles exit the lungs. The study uses long lived radioactively (/sup 57/Co) tagged 3 um insoluble polystyrene particles to follow clearance in a sheep animal model. Particle clearance was characterized by 4 phases. Periodic sacrifice and autopsy showed no particle accumulation in regional lymph nodes draining the lung and no particle accumulation in the liver, spleen or kidneys. Urine and blood samples throughout clearance were devoid of particles, but fecal excretion of particles matched lung elimination of particles and mirrored clearance closely. Thus the avenues of long-term clearance of a 3 um polystrene particle has been established from the alveolar portion of the lung: virtually all particles cleared in 101 days were removed by transport from the alveoli to the mucociliary escalator, either as free particles and/or associated with macrophages and subsequently swallowed and excreted. Particles remaining in the lungs after 101 days continued to be cleared from the lungs via the mucociliary escalator with a t/sub 1/2/ = 38 days. This suggests that particles leave a sequestered state, re-enter the airways and are cleared.

  13. Um satélite brasileiro para observação do diâmetro solar

    NASA Astrophysics Data System (ADS)

    Emilio, M.; Leister, N. V.; Benevides Soares, P.; Teixeira, R.; Kuhn, J.

    2003-08-01

    Propomos uma missão espacial para medir a forma e o diâmetro solar com o objetivo de ajudar a determinar o potencial gravitacional do Sol e a sua rotação com precisão, testar modelos teóricos de variação de energia e pela primeira vez medir os modos g de oscilação. As observações serão obtidas através do instrumento denominado APT (Astrometric and Photometric Telescope) descrito por Kuhn(1983). A sensibilidade do instrumento é de 0,2 mas em 27 dias para as observações do diâmetro solar feitas a cada minuto. Esta é uma missão de três anos de duração e pode complementar as medidas que serão feitas pelo satélite PICARD (a ser lançado em 2007). Outros parâmetros físicos podem ser obtidos com as mesmas imagens o que certamente interessará à comunidade de física solar. Um primeiro contato foi realizado com a agência espacial brasileira que pretende lançar um satélite científico a cada dois anos.

  14. Reducing Striping and Near Field Response Influence in the MODIS 1.38um Cirrus Detection Band.

    NASA Astrophysics Data System (ADS)

    Ackerman, S. A.; Moeller, C. C.; Frey, R. A.; Gumley, L. E.; Menzel, W. P.

    2002-05-01

    Since first light in February 2000, the MODIS L1B data from Terra has exhibited detector striping in the cirrus detection band at 1.38 um (B26). This band's unique characteristic is that it is potentially able to discriminate very thin cirrus (optical depth of 0.1) because water vapor absorption effectively attenuates the upwelling signal from the earth's surface, leaving a flat dark background underneath the thin cirrus. The striping has diminished the power of this band for detecting thin cirrus in the MODIS Cloud Mask (MOD35) over the global environment by imparting a structure on the background. The striping amplitude (valley to peak) is 10 - 15% of the MODIS Ltyp radiance in B26 over land backgrounds, thus exceeding the 5% radiance prelaunch accuracy specification for the band. Also unexpected has been the presence of earth surface reflectance in B26. Forward model calculations indicate that the two-way transmittance of B26 in-band (1% to 1% response) should be < .003 when total precipitable water (TPW) exceeds about 12 mm. However, MODIS B26 imagery has routinely shown land surface reflectance, such as Florida, even in very moist (TPW > 30 mm) tropical air masses. MODIS prelaunch test data suggests that a near field response (NFR) at about 1.3 um in the B26 filter may be contributing to this behavior. A destriping and out-of-band correction algorithm has been under development at the University of Wisconsin to address the these issues. The simple linear algorithm is based on tuning detector dependent influence coefficients for B26 as a function of B5 (1.24 um) radiance so that the corrected B26 radiance is near zero for all B26 detectors in moist atmospheric conditions. B5 was chosen as a surrogate to characterize the NFR leak in the B26 filter because of its close spectral proximity to the NFR leak. Real MODIS L1B data is being used to estimate the influence coefficients. The paper will describe the B5 based destriping and NFR correction algorithm and

  15. Um estudo espectrofotométrico da variável cataclísmica V3885 Sgr

    NASA Astrophysics Data System (ADS)

    Ribeiro, F. M. A.; Diaz, M. P.

    2003-08-01

    Variáveis Cataclísmicas são sistemas binários cerrados compostos de uma anã vermelha que transfere matéria para uma anã branca, em sistemas não magnéticos ocorre a formação de um disco de acresção em torno da anã branca. V3885 Sgr é uma variável cataclísmica classificada como sendo do tipo nova-like. É apresentado um estudo espectrofotométrico de V3885 Sgr de alta resolução temporal feito na região do visível. A região observada é centrada em Ha e abrange também a linha de HeI 6678. O primeiro resultado obtido neste estudo é a determinação do período orbital a partir de medidas da velocidade radial da linha de Ha como sendo 0,20716071(22) dias, resolvendo inconsistências quanto a esse valor na literatura e definindo uma efeméride a longo prazo para o sistema. Com este período e as medidas de velocidade radial do perfil de linha de Ha foi construído um diagrama de massas, através do qual restringimos as massas das componentes estelares do sistema e limitamos a inclinação orbital do sistema. Foram construídos diagramas de Greenstein para as linhas de Ha e HeI, onde os espectros médios em cada intervalo de fase são representados lado a lado em escala de cinza, indicando a existência de uma emissão intensa proveniente da parte posterior do disco. A partir da tomografia Doppler obtivemos perfis de emissividade radial para o disco tanto para a linha de Ha como para HeI. Os resultados obtidos são comparados com os de outros sistemas estudados com a mesma técnica. Serão apresentados também resultados da tomografia de flickering para o sistema.

  16. Mental health problems of undocumented migrants (UMs) in the Netherlands: a qualitative exploration of help-seeking behaviour and experiences with primary care

    PubMed Central

    Teunissen, Erik; Sherally, Jamilah; van den Muijsenbergh, Maria; Dowrick, Chris; van Weel-Baumgarten, Evelyn; van Weel, Chris

    2014-01-01

    Objective To explore health-seeking behaviour and experiences of undocumented migrants (UMs) in general practice in relation to mental health problems. Design Qualitative study using semistructured interviews and thematic analysis. Participants 15 UMs in the Netherlands, varying in age, gender, country of origin and education; inclusion until theoretical saturation was reached. Setting 4 cities in the Netherlands. Results UMs consider mental health problems to be directly related to their precarious living conditions. For support, they refer to friends and religion first, the general practitioner (GP) is their last resort. Barriers for seeking help include taboo on mental health problems, lack of knowledge of and trust in GPs competencies regarding mental health and general barriers in accessing healthcare as an UM (lack of knowledge of the right to access healthcare, fear of prosecution, financial constraints and practical difficulties). Once access has been gained, satisfaction with care is high. This is primarily due to the attitude of the GPs and the effectiveness of the treatment. Reasons for dissatisfaction with GP care are an experienced lack of time, lack of personal attention and absence of physical examination. Expectations of the GP vary, medication for mental health problems is not necessarily seen as a good practice. Conclusions UMs often see their precarious living conditions as an important determinant of their mental health; they do not easily seek help for mental health problems and various barriers hamper access to healthcare for them. Rather than for medication, UMs are looking for encouragement and support from their GP. We recommend that barriers experienced in seeking professional care are tackled at an institutional level as well as at the level of GP. PMID:25416057

  17. Das Märchen vom Zauberer im weißen Kittel: Mythen um berühmte Experimente und Experimentatoren

    NASA Astrophysics Data System (ADS)

    Hentschel, Klaus

    2003-09-01

    Um berühmte Experimentatoren und Experimente ranken sich ebenso Mythen wie um geniale Theoretiker. Sie sind in populärwissenschaftlichen Büchern, Lehrbüchern und sogar in wissenschaftshistorischen Texten verbreitet. Die durch die Aufklärung etablierte Kultur des eleganten Schauexperiments vermittelt ein schiefes Bild vom mühsamen Weg vieler Experimentatoren zum dargestellten Ergebnis. Auch der Mythos des einsamen, genialen Experimentators ohne Helfer widerspricht dem historischen Befund. Gleiches gilt für das experimentum crucis, das eine Theorie als entscheidendes Experiment belegen soll. Die historische Forschung zeigt, dass es eine lange, eigenständige Tradition der experimentellen und instrumentellen Arbeit gibt.

  18. Attitudes of Psychiatric Nurses about the Request for Euthanasia on the Basis of Unbearable Mental Suffering(UMS)

    PubMed Central

    Wampers, Martien; De Lepeleire, Jan; Correll, Christophe U.

    2015-01-01

    Introduction When psychiatric patients express a wish for euthanasia, this should first and foremost be interpreted as a cry for help. Due to their close day-to-day relationship, psychiatric nurses may play an important and central role in responding to such requests. However, little is known about nurses’ attitudes towards euthanasia motivated by unbearable mental suffering. Objectives The aim of this study was to provide insight into the attitudes and actions taken by psychiatric nurses when confronted with a patient’s euthanasia request based on unbearable mental suffering (UMS). Method A questionnaire was sent to 11 psychiatric hospitals in the Flemish part of Belgium. Results The overall response rate was 70% (N = 627). Psychiatric nurses were frequently confronted with a request for euthanasia, either directly (N = 329, 53%) or through a colleague (N = 427, 69%). A majority (N = 536, 84%) did not object to euthanasia in a psychiatrically ill population with UMS. Confounding factors were the psychiatric diagnosis and the type of ward where the nurses were working. Most participants acknowledged a lack of knowledge and skills to adequately address the euthanasia request (N = 434, 71%). Nearly unanimously (N = 618, 99%), study participants indicated that dealing with euthanasia requests and other end-of-life issues should be part of the formal training of nurses. Conclusion The results highlight the need for ethically sound and comprehensive provision of care. Psychiatric nurses play an important role in dealing with the complex issue of requests for euthanasia. There is also a need for education, training and clear guidelines on the level of health care organizations. PMID:26700007

  19. Integration of geophysical and geological data for delimitation of mineralized zones in Um Naggat area, Central Eastern Desert, Egypt

    NASA Astrophysics Data System (ADS)

    Gaafar, Ibrahim

    2015-06-01

    An integrated approach for geophysical, geological and mineralogical data was followed for Um Naggat area, Central Eastern Desert, Egypt, in order to delineate its mineralized zones. The albitized granites are well-defined on the Th- and U-channel images, by their anomalous shapes, reaching 150 ppm and 90 ppm respectively, beside low K content. Interpretations of the aeromagnetic maps delineated four regional structural trends oriented due NNW, NW, ENE and E-W directions. They are identified as strike-slip faults, which coincide well with field observations, where NW-trending faults cut and displace right laterally ENE-trending older ones. The interaction between these two strike-slip fault systems confining the albite granite is easily identified on the regional data presenting longer wavelength anomalies, implying deep-seated structures. They could represent potential pathways for migration of enriched mineralized fluids. Geochemically, albite granites of peraluminous characteristics that had suffered extensive post-magmatic metasomatic reworking, resulted into development of (Zr, Hf, Nb, Ta, U, Th, Sn) and albite-enriched and greisenized granite body of about 600 m thick, and more than 3 km in strike length. The albite granite is characterized by sharp increase in average rare metal content: Zr (830 ppm), Hf (51 ppm), Nb (340 ppm), Ta (44 ppm), and U (90 ppm). Thorite, uranothorite, uraninite and zircon are the main uranium-bearing minerals of magmatic origin within the enclosing granite. However, with respect to Zr, Nb, and Ta, the albitized granite can be categorized as rare metal granite. The integration of airborne geophysical (magnetic and γ-ray spectrometric), geological, geochemical and mineralogical data succeeded in assigning the albite granite of Um Naggat pluton as a mineralized zone. This zone is characterized by its high thorium and uranium of hydrothermal origin as indicated by its low Th/U ratio, with rare metals mineralization controlled by two

  20. Technology Development for High-Efficiency Solar Cells and Modules Using Thin (<80 um) Single-Crystal Silicon Wafers Produced by Epitaxy: June 11, 2011 - April 30, 2013

    SciTech Connect

    Ravi, T. S.

    2013-05-01

    Final technical progress report of Crystal Solar subcontract NEU-31-40054-01. The objective of this 18-month program was to demonstrate the viability of high-efficiency thin (less than 80 um) monocrystalline silicon (Si) solar cells and modules with a low-cost epitaxial growth process.

  1. VizieR Online Data Catalog: 70um-1.2mm and N2H+ maps of IRDC18454 (W43) (Beuther+,

    NASA Astrophysics Data System (ADS)

    Beuther, H.; Tackenberg, J.; Linz, H.; Henning, T.; Krause, O.; Ragan, S.; Nielbock, M.; Launhardt, R.; Schmiedeke, A.; Schuller, F.; Carlhoff, P.; Nguyen-Luong, Q.; Sakai, T.

    2011-11-01

    The cloud complex with a size of ~6'x6' was observed with PACS on Herschel on 2010 March 9. Maps at 250, 350, and 500um were obtained with SPIRE 2010) on 2010 March 11. We observed IRDC18454-1 with the Plateau de Bure Interferometer during five nights in October and November 2009 at 93GHz in the C and D configurations. The N2H+ data has been observed using the BEARS receiver at the NRO 45m telescope in Nobeyama, Japan. The different velocity components have been observed one in April 2010 with an average system temperature of Tsys=206K, the second in June, at slightly lower Tsys. The MIPS 24um data (from MIPSGAL) as well as the IRAC 8um observations (from GLIMPSE) are taken from the Spitzer archive. The 1.2mm continuum data were first presented in Beuther et al. (2002, Cat. J/ApJ/566/945) and the APEX 870um data are part of the ATLASGAL survey of the Galactic plane (Schuller et al., 2009A&A...504..415S). (2 data files).

  2. Geochemistry of the Neoproterozoic metasediments of Malhaq and Um Zariq formations, Kid Metamorphic Complex, Sinai, Egypt: implications for source-area weathering, provenance, recycling, and depositional tectonic setting

    NASA Astrophysics Data System (ADS)

    El-Bialy, Mohammed Z.

    2013-04-01

    The Kid Metamorphic Complex of SE Sinai represents a thick volcano-sedimentary succession that underwent polyphase deformation and greenschist to upper amphibolite facies metamorphism in the NE part of the Arabian-Nubian Shield (ANS). The Malhaq and Um Zariq Formations, the target of this study, occupy roughly the northern half of this complex. The Malhaq Formation records several phases of Ediacaran sedimentation and volcanic activity (615-607 Ma), whereas Um Zariq Formation metasediments are relicts of an older sedimentary sequence (Cryogenian; 813±6 Ma). The Malhaq Formation comprises a series of dark gray structureless to schistose felsic to intermediate metavolcanics interbedded and intercalated with fine- to medium-grained foliated mica-rich phyllites and schists, while the Um Zariq Formation is a dominantly metasedimentary sequence, mainly represented by well-bedded metapelitic schists. Malhaq metasediments are enriched in SiO2, CaO and K2O and depleted in TiO2, Al2O3 and K2O relative to those of Um Zariq Formation. Aside from the relatively low Ni and Cr concentrations, compatible transition elements of these metasediments are comparable to average crustal contents. Except for marked Sr depletion, LILEs are around average continental crust values. Pronounced negative Nb-Ta anomalies in all samples, and general enrichment of Um Zariq samples in Th, U, Zr, Ti and Y relative to Malhaq ones are the main features of HFSEs. The REE patterns of all samples are parallel to sub-parallel LREE-enriched, with distinct negative Eu anomalies and weakly fractionated HREE segments. Geochemical investigations have revealed that the source rocks of Malhaq Formation metasediments underwent mild to moderate chemical weathering, whereas those of Um Zariq Formation have suffered severe chemical weathering. These metasediments are predominately derived from felsic to intermediate igneous sources, with a particular slight addition from recycled sedimentary source to the Malhaq

  3. The Shadow of a Gnomon Along a Year: Routine Observations and Teaching of Apparent Motion of the Sun and the Four Seasons. (Spanish Title: La Sombra de un Gnomon lo Largo de un Año: Observaciones de Rutina y la Enseñanza del Movimiento Aparente del Sol y Las Cuatro Estaciones.) A Sombra de um Gnômon ao Longo de um Ano: Observações Rotineiras e o Ensino do Movimento Aparente do Sol E das Quatro Estações

    NASA Astrophysics Data System (ADS)

    Trogello, Anderson Giovani; Danhoni Neves, Marcos Cesar; de Carvalho Rutz da Silva, Sani

    2013-12-01

    , al solsticio de junio, al equinoccio de septiembre y al solsticio de diciembre. Además, se dictaron clases teóricas en la sala de aula. Estos métodos buscaron construir conceptos en torno al movimiento aparente del Sol y la sucesión de las estaciones. Teniendo en cuenta los resultados de las actividades se aplicó una evaluación cuyos datos demuestran la existencia de un aprendizaje deseado por los estudiantes en cuanto a: el reconocimiento de los puntos cardinales, la descripción del movimiento solar aparente y la aparición de las estaciones y su alternancia a partir de observaciones astronómicas visuales sin instrumentos. Muitas concepções alternativas são reconhecidas entre os diversos grupos de estudantes, em especial nos da educação básica. Dentre elas, o movimento aparente do Sol, por mais quotidiano que seja, proporciona variadas interpretações. Deste modo, observar e registrar o movimento dos astros na abóboda celeste é uma tarefa necessária ao ensino de Astronomia. O trabalho que ora se apresenta propõe a apresentação dos resultados da observação do movimento aparente do Sol por intermédio da marcação da sombra de um gnômon vertical por alunos de uma turma do sexto ano do ensino fundamental de uma escola do campo do Paraná. O projeto em si ocorreu em quatro etapas, em datas próximas do equinócio de março, do solstício de junho, do equinócio de setembro e do solstício de dezembro. Além disso, foram desenvolvidas aulas teóricas em sala de aula. Tais métodos buscaram construir conceitos em torno da movimentação aparente do Sol e da alternância das estações do ano. Diante dos resultados provenientes das atividades desenvolvidas foi aplicada uma avaliação e os dados demonstraram um aprendizado desejado dos alunos quanto: ao reconhecimento dos pontos cardeais; à descrição do movimento solar aparente e a ocorrência das estações do ano e sua alternância a partir de observações astronômicas a olho nu.

  4. Evaluation of high-resolution MetUM and AMPS forecasts of near-surface meteorological variables over Larsen C ice shelf and northern Antarctic Peninsula

    NASA Astrophysics Data System (ADS)

    Orr, Andrew; Kirchgaessner, Amelie; King, John; Weeks, Mark; Gadian, Alan; Kuipers Munneke, Peter; van den Broeke, Michiel; Steffen, Konrad

    2016-04-01

    High-resolution weather forecasts are an important tool for understanding the detailed patterns of surface melt on the Larsen C ice shelf (LCIS), Antarctic Peninsula. We investigate the skill of UK Met Office Unified Model (MetUM) and Antarctic Mesoscale Prediction System (AMPS) forecasts with horizontal grid spacing of 4-5 km for a 1 month period during January-February 2011 by comparing near-surface model output to automatic weather station measurements at 5 sites on the LCIS and 3 on the northern Antarctic Peninsula. Forecasts for the range 12-24 h showed a fairly homogeneous performance over the LCIS. The 2 m temperature simulated by AMPS has a correlation with observations of 0.5-0.6 and a systematic cold bias of around -1 degrees centigrade. By comparison, the MetUM had a higher correlation and was less negatively biased. The simulated surface pressure has a correlation of 0.99 and small biases in both models. AMPS yielded better results than the MetUM for 10 m wind speed, being able to capture particularly well synoptically-driven high wind speeds which the MetUM systematically underestimated. Both models struggle to simulate the 10 m wind direction when the wind conditions are highly variable. The simulation of specific humidity by both models was poor. Both models showed a general reduction in performance over the northern Antarctic Peninsula compared to the LCIS. Extending the analysis to consider the 12-36 h forecast range demonstrated a relatively weak dependence of model skill to the length of the forecast. The study focuses particularly on the representation of foehn wind events, which are an important contributor to surface melt over the LCIS, by examining additional ~1 km scale forecasts using the MetUM.

  5. The dependence of land-atmosphere interactions on atmospheric parametrizations in the JULES/UM modelling system

    NASA Astrophysics Data System (ADS)

    Johnson, Helen; Best, Martin

    2015-04-01

    It has been understood for a while now that atmospheric behaviour is affected by land surface processes, modelling this relationship however still presents challenges. Most numerical weather prediction (NWP) models couple an atmospheric model to a land surface model in order to forecast the weather and/or climate. The Global Land-Atmosphere Coupling Experiment (GLACE) demonstrated that soil moisture variability has considerable control over atmospheric behaviour, particularly impacting on precipitation and temperature variability. The study also suggested that differences in coupling strengths between models may be due to differences in atmospheric parametrizations. There have since been other studies which support this claim but it is not yet clear which parameters control the land-atmosphere coupling strength or indeed what it should be. In this study we investigate whether certain atmospheric parameters hold more control than others over model sensitivity to land surface changes. We focus on the interaction of the JULES (Joint UK Land Environment Simulator) land surface model with the Met Office Unified Model (UM) that is used for operational NWP and climate prediction. For computational efficiency we ran the UM at a single site using a single column model (SCM) rather than running a global model simulation. A site in the Sahel region of West Africa was chosen as this is an area that was identified by GLACE as being especially responsive to changes in soil moisture. JULES was run several times with various different initial soil moisture profiles to create an ensemble of surface sensible and latent heat fluxes that could be used to force a set of different SCM runs in order to simulate a range of different atmospheric conditions. Various atmospheric parameters in the SCM were then perturbed to create additional sets of SCM runs with different sensitivities to soil moisture changes. By analysing the difference in spread between the standard configuration and the

  6. Calcareous benthonic foraminifera across the Cretaceous/Paleocene transition of Gebel Um El-Ghanayem, Kharga Oasis, Egypt

    NASA Astrophysics Data System (ADS)

    Orabi, Orabi H.; Khalil, Hamza M.

    2014-08-01

    The studies of benthic calcareous foraminifera of the Maastrichtian-early Paleocene Dakhla Formation in Gebel Um El-Ghanayem (Western Desert, Egypt), improve reconstruction of depositional environments of these successions. In total, 68 taxa of benthic foraminifera were identified in the studied succession. The late Maastrichtian assemblages (Zone CF3) are dominated by calcareous foraminifera with tapered tests, this tapered taxon Loxostomum applinae, Lox. tegulatum various dentalinid taxa, and Buliminella cushmani dominate in CF3 Biozone. We thus interpret these faunas as being dominated by infaunal morphogroups, suggesting a moderately eutrophic environment. Danian assemblages are characterized by abundant epifaunal trochospiral species, such as Cibicidoides abudurbensis, Cibicidoides farafraensis, and Gyroidinoides girardanus. The infaunal morphogroups make up 25-47% of fauna in the Danian, in contrast to 62-76% in the Upper Maastrichtian. This dominance of the Danian benthic foraminiferal assemblages by epifaunal or mixed epifaunal/infaunal morphogroups suggests that the food supply to the benthos was less abundant than in the latest Cretaceous. The Cretaceous/Paleocene boundary (K/Pg) is within the upper unit of the Lower Kharga Member and marked by a hiatus in at least the top of CF3 Zone of the Upper Maastrichtian to the Lower Paleocene (base Plc Zone).

  7. THE TYPES OF PALAEARCTIC HIPPORHININI (Coleoptera, Curculionidae, Cyclominae) CONSERVED AT THE MUSÉUM NATIONAL D'HISTOIRE NATURELLE, PARIS.

    PubMed

    Meregalli, Massimo; Perrin, Hélène

    2015-01-01

    The Palaearctic species of Curculionidae: Cyclominae: Hipporhinini conserved at the Muséum national d'Histoire Naturelle, Paris were critically revised in order to recognise the type specimens, select lectotypes or, where necessary, designate neotypes. Out of 135 species whose types were presumably preserved in the MNHN, original type specimens of 116 could be found. The holotypes of 21 species were available, either because originally designated as such, or because the species was unequivocally based on a single specimen; a paratype of another taxon, whose holotype is preserved in another collection, was also examined. The lectotypes of 93 species were designated, and a syntype of another species was also seen. Neotypes of 10 more species were designated, thus leading to a total number of species whose type is conserved at the MNHN to 126. Type specimens of five more species described by French authors, not present in the MNHN but conserved in other museums, were found as well and were included in the paper, with the further designation of three lectotypes. All types treated herein were labelled and photographed. PMID:26624774

  8. The UmGcn5 gene encoding histone acetyltransferase from Ustilago maydis is involved in dimorphism and virulence.

    PubMed

    González-Prieto, Juan Manuel; Rosas-Quijano, Raymundo; Domínguez, Angel; Ruiz-Herrera, José

    2014-10-01

    We isolated a gene encoding a histone acetyltransferase from Ustilago maydis (DC.) Cda., which is orthologous to the Saccharomyces cerevisiae GCN5 gene. The gene was isolated from genomic clones identified by their specific hybridization to a gene fragment obtained by the polymerase chain reaction (PCR). This gene (Umgcn5; um05168) contains an open reading frame (ORF) of 1421bp that encodes a putative protein of 473 amino acids with a Mr. of 52.6kDa. The protein exhibits a high degree of homology with histone acetyltransferases from different organisms. Null a2b2 ΔUmgcn5 mutants were constructed by substitution of the region encoding the catalytic site with a hygromycin B resistance cassette. Null a1b1 ΔUmgcn5 mutants were isolated from genetic crosses of a2b2 ΔUmgcn5 and a1b1 wild-type strains in maize. Mutants displayed a slight reduction in growth rate under different conditions, and were more sensitive than the wild type to stress conditions, but more important, they grew as long mycelial cells, and formed fuzz-like colonies under all conditions where wild-type strains grew in the yeast-like morphology and formed smooth colonies. This phenotype was not reverted by cAMP addition. Mutants were not virulent to maize plants, and were unable to form teliospores. These phenotypic alterations of the mutants were reverted by their transformation with the wild-type gene. PMID:25242418

  9. The Myriapoda and Onychophora collection (MY) of the Muséum national d’Histoire naturelle (MNHN, Paris)

    PubMed Central

    Bras, Gwenaël Le; Geoffroy, Jean-Jacques; Albenga, Laurent; Mauriès, Jean-Paul

    2015-01-01

    Abstract The Myriapoda and Onychophora collection dataset inventories the occurrence records of the collection of myriapods and onychophorans in the Muséum national d’Histoire naturelle, Paris. The dataset currently consists of 202 lots of onychophorans, representing all of those present, and almost ten thousand (9 795) lots of myriapods, representing 33 to 40% of the MNHN Myriapoda collection. This collection, which is of key historic importance, represents the results of two centuries of myriapod and onychophoran studies. The sources of the collection are worldwide, with a high representation for metropolitan France for the myriapods. None of the occurrences are yet georeferenced. Access to the dataset via the data portals of the MNHN and the GBIF has been made possible through the e-ReColNat project (ANR-11-INBS-0004). The Myriapoda and Onychophora collection of MNHN is actively expanding, hence both the collection and dataset are in continuous growth. The dataset can be accessed through the portals of GBIF at http://www.gbif.org/dataset/3287044c-8c48-4ad6-81d4-4908071bc8db and the MNHN at http://science.mnhn.fr/institution/mnhn/collection/my/item/search/form. PMID:26448704

  10. The Myriapoda and Onychophora collection (MY) of the Muséum national d'Histoire naturelle (MNHN, Paris).

    PubMed

    Bras, Gwenaël Le; Geoffroy, Jean-Jacques; Albenga, Laurent; Mauriès, Jean-Paul

    2015-01-01

    The Myriapoda and Onychophora collection dataset inventories the occurrence records of the collection of myriapods and onychophorans in the Muséum national d'Histoire naturelle, Paris. The dataset currently consists of 202 lots of onychophorans, representing all of those present, and almost ten thousand (9 795) lots of myriapods, representing 33 to 40% of the MNHN Myriapoda collection. This collection, which is of key historic importance, represents the results of two centuries of myriapod and onychophoran studies. The sources of the collection are worldwide, with a high representation for metropolitan France for the myriapods. None of the occurrences are yet georeferenced. Access to the dataset via the data portals of the MNHN and the GBIF has been made possible through the e-ReColNat project (ANR-11-INBS-0004). The Myriapoda and Onychophora collection of MNHN is actively expanding, hence both the collection and dataset are in continuous growth. The dataset can be accessed through the portals of GBIF at http://www.gbif.org/dataset/3287044c-8c48-4ad6-81d4-4908071bc8db and the MNHN at http://science.mnhn.fr/institution/mnhn/collection/my/item/search/form. PMID:26448704

  11. The Workload of the UMS Faculty. A Report to the Joint Chairs of the Senate Budget and Taxation Committee and the House Appropriations Committee.

    ERIC Educational Resources Information Center

    Maryland Univ. System Administration, Adelphi.

    This report provides the results of a study of faculty workloads in the University of Maryland System (UMS) during the 1994-95 academic year. It was found that 19,446 course units were taught by full-time (FT) faculty at degree-granting institutions, an increase of 158 course units from the previous year while the number of FT faculty decreased by…

  12. Remote sensing detection of gold related alteration zones in Um Rus area, Central Eastern Desert of Egypt

    NASA Astrophysics Data System (ADS)

    Amer, Reda; Kusky, Timothy; El Mezayen, Ahmed

    2012-01-01

    Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) and Phased Array L-band Synthetic Aperture Radar (PALSAR) images covering the Um Rus area in the Central Eastern Desert of Egypt were evaluated for mapping geologic structure, lithology, and gold-related alteration zones. The study area is covered by Pan-African basement rocks including gabbro and granodiorite intruded into a variable mixture of metavolcanics and metasediments. The first three principal component analyses (PCA1, PCA2, PCA3) in a Red-Green-Blue (RGB) of the visible through shortwave-infrared (VNIR + SWIR) ASTER bands enabled the discrimination between lithological units. The results show that ASTER band ratios ((2 + 4)/3, (5 + 7)/6, (7 + 9)/8) in RGB identifies the lithological units and discriminates the granodiorite very well from the adjacent rock units.The granodiorites are dissected by gold-bearing quartz veins surrounded by alteration zones. The microscopic examination of samples collected from the alteration zones shows sericitic and argillic alteration zones. The Spectral Angle Mapper (SAM) and Spectral Information Divergence (SID) supervised classification methods were applied using the reference spectra of the USGS spectral library. The results show that these classification methods are capable of mapping the alteration zones as indicated by field verification work. The PALSAR image was enhanced for fracture mapping using the second moment co-occurrence filter. Overlying extracted faults and alteration zone classification images show that the N30E and N-S fractures represent potential zones for gold exploration. It is concluded that the proposed methods can be used as a powerful tool for ore deposit exploration.

  13. BUDDA (Bulge/Disk Decomposition Analysis) - um novo programa para análise estrutural de galáxias

    NASA Astrophysics Data System (ADS)

    Gadotti, D. A.; de Souza, R. E.; Dos Anjos, S.

    2003-08-01

    Tem sido prática comum nos últimos anos estudar a distribuição de luminosidade em galáxias fazendo uso da informação contida em toda a imagem da galáxia, já que esta técnica tem se mostrado muito mais confiável do que o simples ajuste de perfis radiais de luminosidade. Através destes estudos bidimensionais, melhores resultados tem sido obtidos na análise e.g. do Plano Fundamental, de correlações entre os parâmetros estruturais de galáxias, de sub-estruturas como barras e anéis nucleares etc. Apresentamos um novo código bidimensional, o BUDDA, de análise estrutural de galáxias, que será disponibilizado para a comunidade. Desenvolvido por nós, o código determina os parâmetros estruturais de galáxias de forma prática e robusta, e pode ser aplicado genericamente em qualquer estudo sobre a formação, evolução e estrutura de galáxias. O programa ainda permite a avaliação direta de sub-estruturas, através de imagens residuais que são obtidas ao se subtrair, das imagens originais, bojo e disco sintéticos que melhor representam essas componentes da galáxia sob consideração. Será apresentada a forma de utilização do código, bem como séries de testes que atestam a sua funcionalidade. Além disso, os resultados da aplicação do código em uma amostra de 51 galáxias serão expostos como exemplo prático, e do seu enorme potencial de uso.

  14. Usina de ciências: um espaço pedagógico para aprendizagens múltiplas

    NASA Astrophysics Data System (ADS)

    Martin, V. A. F.; Poppe, P. C. R.; Orrico, A. C. P.; Pereira, M. G.

    2003-08-01

    Entendemos que o Ensino de Astronomia é especialmente apropriado para motivar os alunos e aprofundar conteúdos em diversas áreas do conhecimento, pois envolve temas ligados à Física, Matemática, Química, Computação, Tratamento de Imagens e Instrumentação de Alta Precisão, além daqueles pertinentes as áreas de Geografia, História e Antropologia. Contudo, apesar do caráter interdisciplinar que esta ciência possui, a realidade atual é que a maioria dos professores em sala de aula não foram devidamente capacitados, durante o período de formação acadêmica, para ministrar conteúdos de Astronomia nos atuais Ensinos Fundamental e Médio. Neste trabalho, discutiremos de maneira ampla, num primeiro momento, a realidade do atual ensino de ciências praticado no Estado da Bahia, apontando por dependência administrativa, o crescimento e a redução do número de escolas, da taxa de analfabetismo por faixa etária, da escolarização, do atendimento, da aprovação, reprovação e abandono, de equipamentos e laboratórios e o grau de formação dos nossos atuais professores em pleno exercício de atividade docente. Num segundo momento, discutiremos o papel do Observatório Astronômico Antares/UEFS dentro desse contexto, ou seja, suas ações implementadas ao longo dos últimos anos e em particular, o recente projeto de extensão Ensino e Difusão de Astronomia, financiado pela Fundação Vitae, que procura traduzir no lúdico, no brincar de ciências, um espaço pedagógico para aprendizagens múltiplas. Neste, o papel do professor multiplicador associado ao laboratório de kits didáticos, de fácil construção e manipulação (alguns dos quais serão mostrados), perfazem os principais veículos para o desenvolvimento de conhecimentos, atitudes, habilidades e valores que preparam os nossos alunos para a carreira técnico-científica e para sua participação crítica e criativa na Sociedade.

  15. VizieR Online Data Catalog: 3.6um S4G Galactic bars characterization (Diaz-Garcia+, 2016)

    NASA Astrophysics Data System (ADS)

    Diaz-Garcia, S.; Salo, H.; Laurikainen, E.; Herrera-Endoqui, M.

    decomposition model ('rotationcurve_decomposition.dat'), with the stellar component inferred from the 3.6~um imaging and the halo component estimated using the universal rotation curve models). (5 data files).

  16. Performance of immersion lithography for 45-nm-node CMOS and ultra-high density SRAM with 0.25um2

    NASA Astrophysics Data System (ADS)

    Mimotogi, Shoji; Uesawa, Fumikatsu; Tominaga, Makoto; Fujise, Hiroharu; Sho, Koutaro; Katsumata, Mikio; Hane, Hiroki; Ikegami, Atsushi; Nagahara, Seiji; Ema, Tatsuhiko; Asano, Masafumi; Kanai, Hideki; Kimura, Taiki; Iwai, Masaaki

    2007-03-01

    Immersion lithography was applied to 45nm node logic and 0.25um2 ultra-high density SRAM. The predictable enhancement of focus margin and resolution were obtained for all levels which were exposed by immersion tool. In particular, the immersion lithography enabled to apply the attenuating phase shift mask to the gate level. The enough lithography margin for the alternating phase shift mask was also obtained by using not only immersion tool but also dry tool for gate level. The immersion lithography shrunk the minimum hole pitch from 160nm to 140nm. Thus, the design rule for 45nm node became available by using immersion lithography.

  17. MOBRAL: Un Modelo para la Educacion de Adultos?

    ERIC Educational Resources Information Center

    Convergence, 1974

    1974-01-01

    Written in Spanish, the article explains that expanding an adult basic education program, the Brazilian Literacy Movement (MOBRAL), necessitates considering the social orientation of MOBRAL in the context of Brazil and of Latin America as a whole. (AG)

  18. Astronomical Perception of the Secondary School's Students in São Paulo's State School in Suzano City. (Spanish Title: Percepción Astronómica de Alumnos de la Enseñanza Media de la Red Estatal de San Pablo en la Ciudad de Suzano.) Percepção Astronômica de um Grupo de Alunos do Ensino Médio da Rede Estadual de São Paulo da Cidade de Suzano

    NASA Astrophysics Data System (ADS)

    França de Oliveira, Edilene; Voelzke, Marcos Rincon; Amaral, Luis Henrique

    2007-12-01

    año y 20,6% tenían la idea de cuales son los objetos celestes más cercanos de la Tierra. En contraposición, 67,6% clasificaron correctamente el Sol como una estrella; 55,9% relacionaron el Big Bang al origen del Universo; solamente 20,6% identificaron un año-luz como unidad de distancia y 32,4% reconocieron una estrella fugaz como meteoro. El presente análisis fue expandido para otros grupos de la Enseñanza Media, no solamente del período nocturno, sino también diurno de la misma escuela. En esta primera fase se nota el pequeño conocimiento de los alumnos sobre eventos astronómicos y principalmente la gran confusión sobre el significado correcto de los términos astronómicos populares. Embora a Astronomia seja uma das ciências mais antigas da humanidade e muitos dos conceitos astronômicos serem populares, observa-se que uma parcela significativa dos estudantes encontra-se à margem dessas informações. O presente trabalho visa analisar o nível de conhecimento básico dos alunos do Ensino Médio da Rede Estadual da cidade de Suzano quanto aos fenômenos astronômicos que os rodeiam. Para tanto foi elaborado um formulário constando de questões de múltipla escolha, aplicado no primeiro ano noturno da Escola Estadual Batista Renzi. Num espaço amostral de 34 alunos constatou-se que apenas 29,4% compreendiam a sucessão dos dias; 20,6% explicaram corretamente as estações do ano e 20,6% tinham idéia de quais são os objetos celestes mais próximos da Terra. Em contraposição, 67,6% classificaram corretamente o Sol como estrela; 55,9% relacionaram o Big Bang à origem do Universo; apenas 20,6% identificaram um ano-luz como unidade de distância e 32,4% reconheceram uma estrela cadente como meteoro. A presente análise foi expandida para mais 310 alunos de outras classes de Ensino Médio, não somente do período noturno, mas também diurno da mesma escola. Nesta primeira fase nota-se o pequeno discernimento dos alunos sobre eventos astronômicos e

  19. Structural evolution and Cenozoic tectonostratigraphy of the Cairo-Suez district, north Eastern Desert of Egypt: Field-structural data from Gebel Qattamiya-Gebel Um Reheiat area

    NASA Astrophysics Data System (ADS)

    Hagag, Wael

    2016-06-01

    Detailed field mapping reveals that continental rifting is strongly deforming the Gebel Qattamiya-Gebel Um Reheiat area and the entire Cairo-Suez district, in north Eastern Desert of Egypt. Rift-related structures are predominantly represented by E to WNW, NNW and NW oriented faults. The E to WNW oriented faults are small and build up the Gebel Qattamiya en echelon fault belt, whereas the faults trending NNW and NW establish a pervasive horst and graben structural style involving some rhomb-shape horsts as Gebel Qattamiya (GQRH), Gebel Um Reheiat (GURRH) and south Gebel Um Reheiat (SGURRH). Rock units of the Eocene succession and Oligocene sediments are well exposed and highly controlled by rift-related structures. Rifting was developed through two rift-phases; initial and major ones. The initial phase (a newly recognized phase in this contribution) has been occurred in Late Eocene (Priabonian), while the main phase was prevailing during Late Oligocene-Early Miocene time and is characterized by hydrothermal veins and basaltic eruptions. Continental transtension in the Cairo-Suez district, including the study area, was probably synchronous with a major tectonic stage (Pyrenean-Atlasic movement) of continental collision between African-Arabian and Eurasian plates in Late Eocene-Oligocene time. Field investigation suggests that the transfer of displacement (slip) from the Gulf of Suez proto-rift into the E-W oriented faults ''relays'' is an important mechanism, which helps to explain the current structural framework and tectonic evolution of the Cairo-Suez district. Reactivation of such faults with right-lateral divergent wrenching with NE-SW oriented extension deformed the Cairo-Suez district with several E-W oriented en echelon fault belts (e.g. Gebel Qattamiya fault belt in the study area). Thus the Cairo-Suez district represents an accommodation or transfer zone in northeastern Egypt, intercepting the ''far-field stresses'' from the Arabian-Nubian Shield, the Red

  20. Imagens do céu ontem e hoje - um multimídia interativo de astronomia e uma nova exposição no MAST

    NASA Astrophysics Data System (ADS)

    Caretta, C. A.; Lima, F. P.; Requeijo, F.; Vieira, G. G.; Alves, F.; Valente, M. E. A.; de Almeida, R.; de Garcia, G. C.; Quixadá, A. C.

    2003-08-01

    "Imagens do Céu Ontem e Hoje" é o título de uma nova exposição que está sendo inaugurada no Museu de Astronomia e Ciências Afins (MCT), que inclui experimentos interativos, maquetes, réplicas e 8 terminais de computador com um multimídia interativo sobre Astronomia para consulta dos visitantes. O multimídia apresenta um conteúdo bastante extenso, que engloba quase todos os temas em Astronomia, consistindo numa fonte de divulgação e pesquisa para um público que vai das crianças até estudantes universitários. O conteúdo está distribuído em mais de 500 páginas de texto divididas em 4 módulos: "O Universo", "Espectroscopia", "Telescópios" e "Observando o Céu". Cada módulo é subdividido em 5 seções, em média, cada uma iniciada por uma animação que ilustra os temas a serem abordados na seção. Ao final da animação, uma lista de temas é apresentada sob o título "Saiba Mais". Para exemplificar, o módulo "O Universo" contém as seguintes seções: "O Universo visto pelo homem", "Conhecendo o Sistema Solar", "Indo além do Sistema Solar", "Nossa Galáxia, a Via-Láctea" e "Indo mais além, a imensidão do Universo". A seção "Conhecendo o Sistema Solar", por sua vez, tem os seguintes temas: "A origem do Sistema Solar", "O Sol", "Os planetas", "Satélites, asteróides, cometas e outros bichos..." e "O Sistema Solar em números". Cada texto é repleto de imagens, quadros, desenhos, esquemas, etc, além de passatempos ao final de cada seção, incluindo jogos interativos, quadrinhos e curiosidades, que auxiliam o aprendizado de forma divertida. Apresentamos neste trabalho as idéias gerais que permearam a produção da exposição, e uma viagem pelo multimídia para exemplificar sua estrutura e conteúdo. O multimídia será posteriormente disponibilizado para o público externo pela página eletrônica do MAst e/ou por intermédio de uma publicação comercial.

  1. Um Projeto de Intervenção nos Espaços de Exposições do Planetário do Parque do Ibirapuera

    NASA Astrophysics Data System (ADS)

    Elias, D. S.; Amaral, L. H.; de Araújo, C. F., Jr.; Matsuura, O. T.; Voelzke, M. R.

    2005-08-01

    Cada vez mais a humanidade, em sua imensa maioria, está alheia às próprias conquistas. A insatisfação com esta realidade tem levado muitos pesquisadores, instituições, empresas e governos a procurar formas alternativas de acompanhar e transmitir todo este acervo científico cultural à sociedade, buscando a melhoria da qualidade da divulgação científica e contribuindo para o processo de cultura e alfabetização científica. Não há tempo nem espaço nos limitados planos curriculares do ensino médio e mesmo nos programas de ensino que propiciem a cultura científica e o acompanhamento do vertiginoso progresso científico e tecnológico atual. Neste sentido, a educação formal escolar precisa ser complementada ou acrescida de uma educação informal, extra-escolar, que possa oferecer à sociedade o que a escola não pode oferecer. A interação do público com museus, feiras de ciências, planetários, exposições científicas e/ou culturais é de grande importância para a aquisição e difusão de conhecimentos relacionados ao mundo científico. Reconhecidamente como um modelo de alfabetização científica esses ambientes promovem uma interação social capaz de propiciar de forma efetiva uma melhor relação ensino-aprendizagem com o público. Partindo desta realidade a Universidade Cruzeiro do Sul e a Escola Municipal de Astronomia (EMA) vêm desenvolvendo um projeto de intervenção no espaço em torno do Planetário do Parque do Ibirapuera com o objetivo de se implantar um ambiente de aprendizagem motivador e desafiador que promova a popularização de conteúdos relacionados à astronomia, astrofísica e cosmologia. Busca-se, também, a aproximação e interação do público com exposições que estão sendo implementadas no planetário. Considerando que se trata de um projeto de mestrado em fase inicial o objetivo do presente trabalho é apresentar a concepção básica e os critérios que estão sendo utilizados do ponto de vista pedag

  2. Otimização de procedimento de manobra para indução de reentrada de um satélite retornável

    NASA Astrophysics Data System (ADS)

    Schulz, W.; Suarez, M.

    2003-08-01

    Veículos espaciais que retornam à Terra passam por regimes de velocidade e condições de vôo distintos. Estas diferenças dificultam sua concepção aerodinâmica e o planejamento de seu retorno. A partir de uma proposta de um veículo orbital retornável (satélite SARA, em desenvolvimento no IAE/CTA) para realização de experimentos científicos e tecnológicos em ambiente de baixa gravidade, surge a necessidade de realizarem-se estudos considerando-se os aspectos relativos à sua aerodinâmica. Após o lançamento, o veículo deve permanecer em órbita pelo tempo necessário para a condução de experimentos, sendo depois direcionado à Terra e recuperado em solo. A concepção aerodinâmica é de importância para o vôo em suas diversas fases e deve considerar aspectos relativos à estabilização Aerodinâmica e ao arrasto atmosférico, sendo este último de importância crucial na análise do aquecimento a ser enfrentado. A manobra de retorno inclui considerações sobre as condições atmosféricas e dinâmica de reentrada, devendo ser calculada de forma mais precisa possível. O trabalho proposto avalia estudos da dinâmica de vôo de um satélite recuperável considerando aspectos relativos à determinação orbital com GPS, técnica utilizada com sucesso na CONAE, e seu comportamento aerodinâmico em vôo balístico de retorno, com ênfase em sua fase de reentrada atmosférica. Busca-se otimizar a manobra de reentrada de tal forma que a utilização do sistema GPS garanta minimizar a área de impacto com o solo.

  3. The genus Aphidura (Hemiptera, Aphididae) in the collection of the Muséum national d'Histoire naturelle of Paris, with six new species.

    PubMed

    Nieto Nafría, Juan-Manuel; Mier Durante, Milagros-Pilar; Remaudière, Georges

    2013-01-01

    Specimens were studied of 65 samples of the genus Aphidura (Aphididae, Aphidinae, Macrosiphini) from the collection of the Muséum national d'Histoire naturelle (Paris). The possible synonymies of three pairs of species are discussed. New aphid host plant relationships are reported for Aphidura bozhkoae, Aphidura delmasi, Aphidura ornata, Aphidura pannonica and Aphidura picta; this last species is recorded for first time from Afghanistan. The record of Aphidura pujoli from Pakistan is refuted. The fundatrices, oviparous females and males of Aphidura delmasi are described. Six new species are established: Aphidura gallica sp. n. and Aphidura amphorosiphon sp. n. from specimens caught on species of Silene (Caryophyllaceae) from France and Iran, respectively, Aphidura pakistanensis sp. n., Aphidura graeca sp. n. and Aphidura urmiensis sp. n. from specimens caught on species of Dianthus, Gypsophila and Spergula (Caryophyllaceae) from Pakistan, Greece and Iran, respectively, and Aphidura iranensis sp. n. from specimens caught on Prunus sp. from Iran. Modifications are made to the keys by Blackman and Eastop to aphids living on Dianthus, Gypsophyla, Silene, Spergula and Prinsepia and Prunus (Rosaceae). An identification key to apterous viviparous females of species of Aphidura is also provided. PMID:23950674

  4. The genus Aphidura (Hemiptera, Aphididae) in the collection of the Muséum national d’Histoire naturelle of Paris, with six new species

    PubMed Central

    Nieto Nafría, Juan-Manuel; Mier Durante, Milagros-Pilar; Remaudière, Georges

    2013-01-01

    Abstract Specimens were studied of 65 samples of the genus Aphidura (Aphididae, Aphidinae, Macrosiphini) from the collection of the Muséum national d’Histoire naturelle (Paris). The possible synonymies of three pairs of species are discussed. New aphid host plant relationships are reported for Aphidura bozhkoae, Aphidura delmasi, Aphidura ornata, Aphidura pannonica and Aphidura picta; this last species is recorded for first time from Afghanistan. The record of Aphidura pujoli from Pakistan is refuted. The fundatrices, oviparous females and males of Aphidura delmasi are described. Six new species are established: Aphidura gallica sp. n. and Aphidura amphorosiphon sp. n. from specimens caught on species of Silene (Caryophyllaceae) from France and Iran, respectively, Aphidura pakistanensis sp. n., Aphidura graeca sp. n. and Aphidura urmiensis sp. n. from specimens caught on species of Dianthus, Gypsophila and Spergula (Caryophyllaceae) from Pakistan, Greece and Iran, respectively, and Aphidura iranensis sp. n. from specimens caught on Prunus sp. from Iran. Modifications are made to the keys by Blackman and Eastop to aphids living on Dianthus, Gypsophyla, Silene, Spergula and Prinsepia and Prunus (Rosaceae). An identification key to apterous viviparous females of species of Aphidura is also provided. PMID:23950674

  5. Project UM-HAUL (UnManned Heavy pAyload Unloader and Lander): The design of a reusable lunar lander with an independent cargo unloader

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Project UM-Haul is the preliminary design of a reusable lunar transportation vehicle that travels between a lunar parking orbit and the lunar surface. This vehicle is an indispensible link in the overall task of establishing a lunar base as defined by the NASA Space Exploration Initiative. The response to this need consists of two independent vehicles: a lander and an unloader. The system can navigate and unload itself with a minimum amount of human intervention. The design addresses structural analysis, propulsion, power, controls, communications, payload handling and orbital operations. The Lander has the capacity to decend from low lunar orbit (LLO) to the lunar surface carrying a 7000 kg payload, plus the unloader, plus propellant for ascent to LLO. The Lander employs the Unloader by way of a motorized ramp. The Unloader is a terrain vehicle capable of carrying cargoes of 8,500 kg mass and employs a lift system to lower payloads to the ground. The system can perform ten missions before requiring major servicing.

  6. Modelling future changes in climate, ozone-depleting substances and ozone precursor emissions using the whole-atmosphere UM-UKCA model

    NASA Astrophysics Data System (ADS)

    Banerjee, A.; Archibald, A. T.; Maycock, A. C.; Abraham, L.; Telford, P.; Braesicke, P.; Pyle, J. A.

    2013-12-01

    Using the recently upgraded whole-atmosphere UM-UKCA chemistry-climate model, we investigate the atmospheric response to future changes in a) greenhouse gases under the RCP4.5 and 8.5 scenarios for climate change, b) ozone-depleting substances (ODS) and a recovery of the ozone layer and c) ozone precursor emissions and tropospheric oxidising capacity. In addition, we combine theses scenarios in order to explore the interactions between individual perturbations. Within this framework, the coupled stratosphere-troposphere system and whole-atmosphere chemistry allows us to study the impacts of changes in composition of the stratosphere on the troposphere and vice versa. Under a scenario for moderate climate change (RCP4.5), we find that by the year 2100: 1) the stratosphere significantly impacts the troposphere via changes in stratosphere-troposphere exchange (STE) but the chemical changes induced in the troposphere do not impact the stratosphere, 2) perturbations are linearly additive with regard to the total ozone column and tropospheric odd oxygen budget, 3) while the Brewer-Dobson circulation strengthens under climate change (with an increase in the tropical upward mass flux at 70hPa of 17%), this strengthening is offset by ozone recovery (which on its own leads to a decrease in the mass flux of 9%) and 4) the tropospheric ozone burden decreases by 10% given mitigation of its precursor emissions but this is offset by climate change and stratospheric ozone recovery (9% and 6% increases in the burden respectively).

  7. Age-related Changes in Auditory Nerve – Inner Hair Cell Connections, Hair Cell Numbers, Auditory Brain Stem Response and Gap Detection in UM-HET4 Mice

    PubMed Central

    Altschuler, RA; Dolan, DF; Halsey, K; Kanicki, A; Deng, N; Martin, C; Eberle, J; Kohrman, DC; Miller, RA; Schacht, J

    2015-01-01

    This study compared the timing of appearance of three components of age-related hearing loss that determine the pattern and severity of presbycusis: the functional and structural pathologies of sensory cells and neurons and changes in Gap Detection, the latter as an indicator of auditory temporal processing. Using UM-HET4 mice, genetically heterogeneous mice derived from four inbred strains, we studied the integrity of inner and outer hair cells by position along the cochlear spiral, inner hair cell-auditory nerve connections, spiral ganglion neurons, and determined auditory thresholds, as well as pre-pulse and gap inhibition of the acoustic startle reflex (ASR). Comparisons were made between mice of 5-7, 22-24 and 27-29 months of age. There was individual variability among mice in the onset and extent of age-related auditory pathology. At 22-24 months of age a moderate to large loss of outer hair cells was restricted to the apical third of the cochlea and threshold shifts in auditory brain stem response were minimal. There was also a large and significant loss of inner hair cell – auditory nerve connections and a significant reduction in Gap Detection. The expression of Ntf3 in the cochlea was significantly reduced. At 27-29 months of age there was no further change in the mean number of synaptic connections per inner hair cell or in gap detection, but a moderate to large loss of outer hair cells was found across all cochlear turns as well as significantly increased ABR threshold shifts at 4, 12, 24 and 48 kHz. A statistical analysis of correlations on an individual animal basis revealed that neither the hair cell loss nor the ABR threshold shifts correlated with loss of gap detection or with the loss of connections, consistent with independent pathological mechanisms. PMID:25665752

  8. Age-related changes in auditory nerve-inner hair cell connections, hair cell numbers, auditory brain stem response and gap detection in UM-HET4 mice.

    PubMed

    Altschuler, R A; Dolan, D F; Halsey, K; Kanicki, A; Deng, N; Martin, C; Eberle, J; Kohrman, D C; Miller, R A; Schacht, J

    2015-04-30

    This study compared the timing of appearance of three components of age-related hearing loss that determine the pattern and severity of presbycusis: the functional and structural pathologies of sensory cells and neurons and changes in gap detection (GD), the latter as an indicator of auditory temporal processing. Using UM-HET4 mice, genetically heterogeneous mice derived from four inbred strains, we studied the integrity of inner and outer hair cells by position along the cochlear spiral, inner hair cell-auditory nerve connections, spiral ganglion neurons (SGN), and determined auditory thresholds, as well as pre-pulse and gap inhibition of the acoustic startle reflex (ASR). Comparisons were made between mice of 5-7, 22-24 and 27-29 months of age. There was individual variability among mice in the onset and extent of age-related auditory pathology. At 22-24 months of age a moderate to large loss of outer hair cells was restricted to the apical third of the cochlea and threshold shifts in the auditory brain stem response were minimal. There was also a large and significant loss of inner hair cell-auditory nerve connections and a significant reduction in GD. The expression of Ntf3 in the cochlea was significantly reduced. At 27-29 months of age there was no further change in the mean number of synaptic connections per inner hair cell or in GD, but a moderate to large loss of outer hair cells was found across all cochlear turns as well as significantly increased ABR threshold shifts at 4, 12, 24 and 48 kHz. A statistical analysis of correlations on an individual animal basis revealed that neither the hair cell loss nor the ABR threshold shifts correlated with loss of GD or with the loss of connections, consistent with independent pathological mechanisms. PMID:25665752

  9. Espectroscopia multi-objeto e imageamento de Abell 586 com GMOS - o estado dinâmico de um aglomerado de galáxias com arcos gravitacionais

    NASA Astrophysics Data System (ADS)

    Cypriano, E. S.; Sodrã©, L., Jr.; Kneib, J.-P.; Campusano, L.

    2003-08-01

    Nesse trabalho é apresentado um estudo do conteúdo de massa do aglomerado de galáxias A586 (z = 0.171) bem como sua distribuição espacial. Isso foi feito a partir de dados de espectroscopia multi-objeto e imageamento obtidos com o instrumento GMOS acoplado ao telescópio Gemini-Norte. A massa desse aglomerado foi estudada a partir da posição dos seus arcos gravitacionais (lentes fortes), da medida estatística da distorção na forma das galáxias de fundo (lentes fracas) e através da dispersão de velocidades de uma amostra de cerca de 30 galáxias pertencentes ao aglomerado (teorema do virial). Os dois primeiros métodos não dependem do estado dinâmico do aglomerado, enquanto que o terceiro sim. Desse modo, comparando seus resultados pode-se estimar o grau de relaxamento desse sistema. Dados de raios X presentes na literatura também serão incluídos nessa análise. Nossos resultados preliminares a partir das técnicas de lentes fracas, mostram que, supondo que a distribuição de massa desse aglomerado seja a de uma esfera isotérmica, espera-se que ele apresente uma dispersão de velocidades de 1330+/-78 km s-1, em contradicao com medidas similares feitas por Dahle et al. 2002 que encontram valores tão altos quanto 1680 km s-1. Já o estudo dinâmico resultou numa dispersão de velocidades de ~950 km s-1.

  10. Modelling future changes in climate, ozone-depleting substances and ozone precursor emissions using the whole-atmosphere UM-UKCA model

    NASA Astrophysics Data System (ADS)

    Banerjee, Antara; Maycock, Amanda; Archibald, Alexander; Telford, Paul; Abraham, Luke; Braesicke, Peter; Pyle, John

    2014-05-01

    Using the recently upgraded whole-atmosphere UM-UKCA chemistry-climate model, we investigate the atmospheric response to future changes in a) greenhouse gases under the RCP4.5 and 8.5 scenarios for climate change, b) ozone-depleting substances (ODS) and a recovery of the ozone layer and c) ozone precursor emissions and tropospheric oxidising capacity. In addition, we combine these scenarios in order to explore the interactions between individual perturbations. Within this framework, the coupled stratosphere-troposphere system and whole-atmosphere chemistry allows us to study the impact of changes in composition of the stratosphere on the troposphere and vice versa. We find that by the year 2100: 1) the stratosphere significantly impacts the troposphere via changes in stratosphere-troposphere exchange (STE) but the chemical changes induced in the troposphere do not impact the stratosphere, 2) perturbations are linearly additive with regard to the total ozone column and tropospheric odd oxygen budget, 3) while the Brewer-Dobson Circulation strengthens under climate change (with an increase in the DJF 70hPa tropical upwards mass flux of ~20% at RCP4.5 and exceeding 30% at RCP8.5), this strengthening is offset by ozone recovery (which on its own leads to a decrease in the mass flux of ~10%) and 4) tropospheric ozone decreases given mitigation of its precursor emissions (with a 10% decrease in ozone burden) but this can be offset by climate change at both RCP4.5 and 8.5 and stratospheric ozone recovery (increasing the burden by 6-13%).

  11. Ho-Nee-Um Trail.

    ERIC Educational Resources Information Center

    Irwin, Harriet; And Others

    Appreciation and concern for the preservation of our natural resources by all citizens is the primary concern of this teacher's guide for use in the elementary grades. It employes the use of a filmstrip in conjunction with a local nature trail, to guide students in developing awareness - by looking closely, listening, touching, and smelling. Major…

  12. Plan de estudios de nivel secundario para adultos (Study Plan for Adult Secondary Education).

    ERIC Educational Resources Information Center

    Boletin del Centro Nacional de Documentacion e Informacion Educativa, Parte II: Informaciones, 1970

    1970-01-01

    This document describes an experimental, multinational plan for adult secondary education sponsored through the Organization of American States and the Argentine Ministry of Culture and Education. General and specific goals of the program are listed here along with details of the proposed curriculum and areas of study, entrance requirements,…

  13. Revista Interamericana de Educacion de Adultos, 2002 (Interamerican Review of Adult Education, 2002).

    ERIC Educational Resources Information Center

    Guerra, Alfonso Rangel, Ed.

    2002-01-01

    This collection of Spanish-language articles includes the following: "La Importancia del Contexto en la Alfabetizacion" (Judith Kalman); "Profesorodo y Formadores: La Formacion para la Transformation de los Distritos y las Comunidades" (Concepcion Dominquez Garrido and Antonio Medina Rivilla); "Valoracion de los Resultados del Proyecto: 'Mujeres…

  14. Mecanismos de plasticidad (funcional y dependiente de actividad) en el cerebro auditivo adulto y en desarrollo

    PubMed Central

    Izquierdo, M.A.; Oliver, D.L.; Malmierca, M.S.

    2010-01-01

    Summary Introduction and development Sensory systems show a topographic representation of the sensory epithelium in the central nervous system. In the auditory system this representation originates tonotopic maps. For the last four decades these changes in tonotopic maps have been widely studied either after peripheral mechanical lesions or by exposing animals to an augmented acoustic environment. These sensory manipulations induce plastic reorganizations in the tonotopic map of the auditory cortex. By contrast, acoustic trauma does not seem to induce functional plasticity at subcortical nuclei. Mechanisms that generate these changes differ in their molecular basis and temporal course and we can distinguish two different mechanisms: those involving an active reorganization process, and those that show a simple reflection of the loss of peripheral afferences. Only the former involve a genuine process of plastic reorganization. Neuronal plasticity is critical for the normal development and function of the adult auditory system, as well as for the rehabilitation needed after the implantation of auditory prostheses. However, development of plasticity can also generate abnormal sensation like tinnitus. Recently, a new concept in neurobiology so-called ‘neuronal stability’ has emerged and its implications and conceptual basis could help to improve the treatments of hearing loss. Conclusion A combination of neuronal plasticity and stability is suggested as a powerful and promising future strategy in the design of new treatments of hearing loss. PMID:19340783

  15. Revista Interamericana de Educacion de Adultos, 2001 (Interamerican Journal of Adult Education, 2001).

    ERIC Educational Resources Information Center

    Guerra, Alfonso Rangel, Ed.

    2001-01-01

    Articles in this volume, written in Spanish, focus on the following: high school education in rural areas; adult and popular education in the 90s; systemizing educational processes in rural communities based on a restoration of their cultural heritage (case Tzintzuntzan, Michoacan); fostering sustainable communities; human rights and human…

  16. Revista Interamericana de Educacion de Adultos, 2000 (Interamerican Review of Adult Education, 2000).

    ERIC Educational Resources Information Center

    Soberanes, Juan F. Millan, Ed.

    2000-01-01

    This collection of Spanish language papers on adult literacy education includes the following: "Sistematizacion: Un Instrumento Pedagogico en los Proyectos de Desarrollo Sustenable" [Systematization: A Pedagogic Instrument in Projects of Sustainable Development] (Joao Francisco de Souza); "Estudio Cualitativo de la Investigacion Sobre Niveles de…

  17. Revista Interamericana de Educacion de Adultos (Interamerican Journal of Adult Education).

    ERIC Educational Resources Information Center

    Revista Interamericana de Educacion de Adultos, 1993

    1993-01-01

    The two issues of this serial include the following articles: "Seminar-Workshop on Regional Diagnostics, Program Development, and Evaluation" (Beatrice Edwards); "Training as a Factor of Stability" (Francisco Largaespada Pereira); "Workplace, Society, and Culture. Viewpoint from Social Interaction" (Nuria Torres Latorre); "Global Vision of Adult…

  18. Interaccion adulto-nino en la escuela infantil (Adult-Child Interaction in Nursery School).

    ERIC Educational Resources Information Center

    Angel, C.; And Others

    1993-01-01

    Examined teacher-child interactions in 2 nursery schools in Barcelona, Spain, when the children (15 2-year olds and 15 4-year olds) were alone or in a group, observing a group in which they were a member, and not part of a group. For these conditions, compared differences in age, gender, and the forms of verbal and nonverbal communication used.…

  19. Sternbilder - Sternsagen. Mythen und Legenden um Sternbilder.

    NASA Astrophysics Data System (ADS)

    Bonov, A.

    This book is a German translation (translator L. Korniljew) of the Bulgarian original "Mitove i legendi za s'zvezdiyata"; Sofia 1978.It describes in detail how starsand star constellations were named and presents accounts of the mythological legends associated with these names.

  20. Determinação da massa de júpiter a partir das órbitas de seus satélites: um experimento didático

    NASA Astrophysics Data System (ADS)

    Schlickmann, M. S.; Saito, R. K.; Becker, D. A.; Rezende, M. F., Jr.; Cid Fernandes, R.

    2003-08-01

    Este trabalho apresenta o roteiro piloto de uma prática observacional em astronomia, junto com os primeiros resultados obtidos nesta fase de implementacão. O projeto, que será executado em duas etapas, visa introduzir noções de Astronomia a alunos do Ensino Médio e iniciantes nos cursos de Física. O experimento consiste em medir as órbitas dos satélites Galileanos e, a partir da análise dos dados coletados, verificar a validade da Lei das órbitas de Kepler, determinando a massa do planeta Júpiter. Em uma primeira etapa, as observações serão feitas utilizando um telescópio Meade LX200 10" e câmera CCD para obter uma seqüência de imagens do planeta, que possibilitará medir o movimento de seus satélites. A segunda etapa terá início a partir do funcionamento do telescópio em modo robótico, com a possibilidade de observações via internet por instituições de ensino. Para o desenvolvimento deste experimento foram inicialmente coletadas várias imagens de Júpiter obtidas com os instrumentos citados acima. Estas imagens serviram como base para confecção dos roteiros para a experiência no nível médio e superior. Os roteiros serão inicialmente apresentados em uma home-page. Nela também se buscará uma contextualização histórica da experiência bem como o estabelecimento de relações com professores e alunos, propostas metodológicas e a disponibilização dos programas computacionais necessários para a utilização "on-line" pelos usuários. O projeto conta com apoio da Fundação VITAE.

  1. Uma análise do fenômeno “alternância de línguas” na fala de bilíngues intermodais (Libras e Português)

    PubMed Central

    de Sousa, Aline Nunes; de Quadros, Ronice Müller

    2013-01-01

    Um interessante fenômeno lingüístico presente nas interações das pessoas bilíngues é a alternância de línguas. Neste trabalho, estamos investigando a alternância entre a língua portuguesa oral e a língua de sinais brasileira – Libras, numa mesma cadeia enunciativa, com o objetivo de identificar e analisar o uso dessa alternância na fala de uma criança e de um adulto (ambos ouvintes, filhos de pais surdos), interagindo em uma situação de bilinguismo intermodal, com interlocutores surdos e ouvintes. A alternância de línguas, nesse caso, ocorre quando se para de falar em português e se alterna para sinalizar. O presente trabalho se caracteriza como um estudo inicial, com análise qualitativa de dados. Fazem parte do nosso corpus nove sessões de interações em Libras e em português oral, gravadas em vídeo, que fazem parte do Projeto Desenvolvimento Bilíngue Bimodal da UFSC. Os dados revelam que as características da alternância de línguas pelo adulto e pela criança parecem ter semelhanças e diferenças. O sujeito adulto parece ter feito um uso da alternância mais preocupado com o curso da interação. A criança, por sua vez, não parece tê-la usado com propósitos pragmáticos específicos. Quanto à extensão das alternâncias, pode-se perceber que tanto a criança quanto o adulto utilizaram enunciados maiores do que uma única palavra isolada. O papel dos interlocutores parece ter sido decisivo nas interações aqui investigadas – especialmente nas do adulto, já que a criança ainda está em processo de tomada de consciência do papel do interlocutor na interação. PMID:24379831

  2. Vínculos sobre um modelo de quartessência de Chaplygin usando observações do satélite chandra da fração de massa de gás em aglomerados de galáxias

    NASA Astrophysics Data System (ADS)

    de Souza, R. S.

    2003-08-01

    Observações de Supernovas do tipo Ia mostram que a expansão do Universo está acelerando. Segundo as equações de Einstein uma componente com pressão negativa (energia escura) é necessária para explicar a aceleração cósmica. Além da energia escura é usualmente admitido que no Universo há também uma matéria exótica com pressão zero, que é chamada de matéria escura. Essa componente possui um papel fundamental na formação de estruturas no Universo. Recentemente tem se explorado a possibilidade de que matéria e energia escura poderiam ser unificadas através de uma única componente, que tem sido denominada de quartessência. Um exemplo de fluido com essas características é o Gás de Chaplygin Generalizado, que possui uma equação de estado da forma p = -A/ra. Inicialmente consideramos o caso especial a = 1 (gás de Chaplygin) e vinculamos parâmetros do modelo utilizando observações em raios-X do satélite Chandra da fração de massa de gás em aglomerados de galáxias. Uma comparação dos vínculos obtidos com esse teste com outros testes, tais como supernovas e idade do Universo, mostra que esse teste é bastante restritivo. Exibiremos ainda resultados para o caso em que a curvatura é nula e o parâmetro a está compreendido no intervalo -1 < a 1.

  3. Modelo Pedagogico de Educacion Primaria para Adultos: Manual para la Vinculacion y Funcionamiento de los Comites de Educacion para Adultos (A Teaching Model for Adult Primary Education: Manual for the Continuation and Operation of Adult Education Committees).

    ERIC Educational Resources Information Center

    Instituto Nacional para la Educacion de los Adultos, Mexico City (Mexico).

    This manual is part of a Mexican series of instructional materials designed for Spanish speaking adults who are in the process of becoming literate or have recently become literate in their native language. This document describes the concept of a model for community adult education for the purpose of supporting local educational committees…

  4. Nuestra Familia: Primaria para Adultos. Segunda Parte. Edicion Experimental (Our Family: Primer for Adults. Part Two. Experimental Edition).

    ERIC Educational Resources Information Center

    Instituto Nacional para la Educacion de los Adultos, Mexico City (Mexico).

    This textbook is part of a Mexican series of instructional materials designed for Spanish speaking adults who are in the process of becoming literate or have recently become literate in their native language. It is designed to orient people with little education or developing literacy skills to a sense of responsibility toward their families.…

  5. Nuestro Trabajo: Primaria para Adultos. Segunda Parte. Edicion Experimental (Our Work: Primer for Adults. Part Two. Experimental Edition).

    ERIC Educational Resources Information Center

    Instituto Nacional para la Educacion de los Adultos, Mexico City (Mexico).

    This workbook is part of a Mexican series of instructional materials designed for Spanish speaking adults who are in the process of becoming literate or have recently become literate in their native language. This workbook is designed to orient people who are only recently literate to the world of work and business. Topics covered include worker…

  6. MOBRAL--Seminario Interamericano de Educacion de Adultos (MOBRAL--Interamerican Seminar on Adult Education). Final Report.

    ERIC Educational Resources Information Center

    Ministerio da Educacao e Cultura, Rio de Janeiro (Brazil). Movimento Brasileiro de Alfabetizacao.

    The report contains the substance of the MOBRAL (Movimento Brasileiro de Alfabetizacao)--Interamerican Seminar on Adult Education held in Rio de Janeiro from April 9th to 18th, 1973, for invited representatives from 21 Latin America and Caribbean countries. The object was to make a contribution to the collective task of identifying, defining, and…

  7. La Communicacion en la educacion de Adultos y el Desarrollo Rural (Adult Literacy and Rural Development). Cuadernos del CREFAL 14.

    ERIC Educational Resources Information Center

    Vejarano, Gilberto M.; And Others

    This booklet presents the ideas that came out of the Regional Meeting for Adult Literacy and Rural Development. The meeting took place in September 1981 at the Regional Center for Adult Education and Functional Literacy for Latin America (CREFAL) in Mexico. Basically, a discussion of adult literacy in the rural areas of Latin America is presented.…

  8. Nuestra Comunidad: Primaria para Adultos. Segunda Parte. Edicion Experimental (Our Community: Primer for Adults. Part Two. Experimental Edition).

    ERIC Educational Resources Information Center

    Instituto Nacional para la Educacion de los Adultos, Mexico City (Mexico).

    This textbook is part of a Mexican series of instructional materials designed for Spanish speaking adults who are in the process of becoming literate or have recently become literate in their native language. It is designed to teach people with developing literacy skills to participate in a meaningful way in the life of their community. Topics…

  9. Comparative research on medicine application with 0.53-um, 1.06-um, and 1.32-um Nd:YAG lasers

    NASA Astrophysics Data System (ADS)

    Li, Yahua; Li, Zhenjia; Zhu, Changhong; Huang, Yizhong

    1996-09-01

    Because of its high power and excellent optical features, laser has almost been applied to everywhere of medical research and clinic. Over the past several years, laser medical has achieved a rapid progress, and laser medical instruments has developed promptly, each new wavelength can be successfully applied in diagnostic and treatment of diseases. Among the medical lasers, Nd:YAG solid-state laser systems have proven useful in surgical use operate, such as neurosurgery, gastroenterology, cardioangiology, urology, gynecology, dermatology and ENT. As with other solid-state lasers, the Nd:YAG laser can be made to emit various wavelengths by means of suitable resonator configurations and some newest solid-state laser technology, pumped by the Krypton lamp, the Nd:YAG laser at room temperature exhibits transition at 1.06 micrometer Nd:YAG, using nonlinear crystal and Q-switch to double its frequency can attain 0.53 micrometer green beam. In our laser systems, the efficiency at 1.06 micrometer is more than 3 percent, an efficiency of 0.5 percent at 1.32 micrometer and 0.53 micrometer can be attained. For a power of 100w at 1.06 micrometer, 15w at 1.32 micrometer and 0.53 micrometer can therefore be produced. All of three kinds Nd:YAG laser hold these characteristics: high output power; optical fiber transition that can be cooperated with endoscope. The paper mainly discusses laser operating characteristics and clinic applications of three kinds wavelengths at 0.53 micrometer 1.06 micrometer and 1.32 micrometer Nd:YAG laser systems.

  10. Astronomy in High School: Using a Mini-Planetarium to Understand Details of the Apparent Movement of Stars. (Spanish Title: Astronomía en la Escuela Secundaria: Comprendiendo los Detalles del Movimiento Aparente de Las Estrellas con un Miniplanetario.) Astronomia no Ensino Médio: Compreendendo Detalhes do Movimento Aparente das Estrelas com um Miniplanetário

    NASA Astrophysics Data System (ADS)

    dos Santos Leão, Demetrius

    2013-07-01

    en la comprensión de estas cuestiones y demostraron un gran interés por esta metodología. O objetivo deste artigo é apresentar parte dos resultados obtidos com a intervenção feita como projeto da dissertação de mestrado do autor, que consistiu no desenvolvimento de um conjunto de aulas de Astronomia, com alunos do 1º Ano do Ensino Médio de uma escola da rede privada do Distrito Federal (Brasília, Brasil), empregando como recurso principal um material didático chamado miniplanetário (MP). Utilizando como pressuposto teórico norteador dessas aulas as ideias de contextualização e dialogicidade de Paulo Freire, foi proposta aos estudantes a montagem e utilização desse recurso em uma sessão de planetário. Durante o projeto, enfatizaram-se assuntos como a trajetória aparente das estrelas para o céu de Brasília, a localização dos pontos cardeais a partir da constelação do Cruzeiro do Sul, as cores das estrelas e as estrelas vistas de uma determinada localidade. Apurou-se que os alunos apresentaram melhoria na compreensão desses assuntos, bem como demonstraram expressiva empolgação com essa metodologia desenvolvida.

  11. Thermal levitation of 10 um size particles in low vacuum

    NASA Astrophysics Data System (ADS)

    Fung, Long Fung Frankie; Kowalski, Nicholas; Parker, Colin; Chin, Cheng

    2016-05-01

    We report on experimental methods for trapping 10 micron-sized ice, glass, ceramic and polyethylene particles with thermophoresis in medium vacuum, at pressures between 5 Torr and 25 Torr. Under appropriate conditions particles can launch and levitate robustly for up to an hour. We describe the experimental setup used to produce the temperature gradient necessary for the levitation, as well as our procedure for generating and introducing ice into the experimental setup. In addition to analyzing the conditions necessary for levitation, and the dependence of levitation on the experimental parameters, we report on the behavior of particles during levitation and ejection, including position and stability, under different pressures and temperatures. We also note a significant discrepancy between theory and data, suggesting the presence of other levitating forces.

  12. Grant UM1CA167462 | Division of Cancer Prevention

    Cancer.gov

    The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

  13. Spatial deconvolution of IRAS galaxies at 60 UM

    NASA Technical Reports Server (NTRS)

    Low, Frank J.

    1987-01-01

    Using IRAS in a slow scan observing mode to increase the spatial sampling rate and a deconvolution analysis to increase the spatial resolution, several bright galaxies were resolved at 60 micron. Preliminary results for M 82, NGC 1068, NGC 3079 and NGC 2623 show partially resolved emission from 10 to 26 arcsec., full width at half maximum, and extended emission from 30 to 90 arcsec. from the center. In addition, the interacting system, Arp 82, along with Mark 231 and Arp 220 were studied using the program ADDSCAN to average all available survey mode observations. The Arp 82 system is well resolved after deconvolution and its brighter component is extended; the two most luminous objects are not resolved with an upper limit of 15 arcsec. for Arp 220.

  14. Exploring Ho-Nee-Um in the Spring.

    ERIC Educational Resources Information Center

    Madison Public Schools, WI.

    Appreciation and concern for the preservation of our natural resources by all citizens is the primary concern of this teacher's guide for use in grades three and four. It employs the use of a filmstrip in conjunction with a local nature trail, to guide students in developing awareness--by looking closely, listening, touching, and smelling. The…

  15. A Winter Walk at Ho-Nee-Um.

    ERIC Educational Resources Information Center

    Irwin, Harriet; And Others

    Appreciation and concern for the preservation of our natural resources by all citizens is the primary concern of this teacher's guide for use in the lower primary grades. It employs the use of a filmstrip in conjunction with a local nature trail, to guide students in developing awareness - by looking closely, listening, touching, and smelling. The…

  16. Um Olhar sobre "Beleza Americana" (A Look at "American Beauty").

    ERIC Educational Resources Information Center

    Bissoto, Maria Luisa

    2000-01-01

    Discusses the film "American Beauty" in light of a reading of Karl Marx. Finds that the film shows the circularity which marks bourgeois society, even though the rhythm of industry and renovation of the society masks it. States that Marx praises the industry, invention, and innovation of the bourgeoisie. (BT)

  17. Grant UM1CA182883 | Division of Cancer Prevention

    Cancer.gov

    The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

  18. Astronomy around 1700. (German Title: Astronomie um 1700)

    NASA Astrophysics Data System (ADS)

    Herbst, Klaus-Dieter

    The book focuses on Gottfried Kirch und Olaus Römer, two scholars who played a leading role in astronomy around 1700. It contains an annotated edition of the letter by Gottfried Kirch to Olaus Römer of October 25, 1703. Kirch was the astronomer of the Berlin Academy of Sciences since 1700, recognized both as astronomical calculator and as observer - Römer was director of the Copenhagen Observatory and was the first who determined the speed of light. Kirch's letter to Römer of October 1703, given here together with several addenda, was not a letter in the modern sense, but a treatise of broad contents, dealing with different astronomical items of that time: the problem of determining stellar and planetary positions, the subjective view on contemporaries, the methods of astronomical calculations, the discovery of comets and other questions are described in Kirch's vivid words. Numerous annotations by the editor explain the astronomy of that time. The editor leads the reader step by step through the methods of astronomical calculations, which become clear and understandable. A complete bibliography of works by and about Kirch and a list of known archival sources are added.

  19. GEO-CAPE application, demonstrated for CO by the IIP Tropospheric Infrared Mapping Spectrometers (TIMS), and scaled to an expanded application that adds the 9.6, 3.3 and 3.6 um bands for multi-layer tropospheric ozone and for HCHO

    NASA Astrophysics Data System (ADS)

    Kumer, J. B.; Roche, A. E.; Rairden, R. L.; Jamieson, T. H.; Mergenthaler, J. L.; Chatfield, R. B.

    2008-12-01

    The NASA Earth Science Technology Office (ESTO) Instrument Incubator Program (IIP) Tropospheric Infrared Mapping Spectrometers (TIMS) have been developed to demonstrate measurement capability, when deployed in space, for multi-layer retrieval of CO from spectral measurements acquired in the solar reflective (SR) region ~ 4281 to 4301 cm-1 and in the thermal InfraRed (TIR) region ~ 2110 to 2165 cm 1. As presented at this meeting in our poster "...multi-layer CO retrieval from atmospheric data..." very encouraging retrieval for CO, H2O, CH4 and albedo were obtained in an operational mode of ground based atmospheric observations that simulated space based operations in an application that would meet Decadal Survey GEO- CAPE air quality observation requirements for coverage, footprint size and refresh time. In this presentation we'll describe the details of how the ground based operations map to the space based operations. We will discuss concept details including [a] the approach for instrument cooling, [b] the scanning mirror and telescope system that would provide input to the TIMS in a way that meets the GEO-CAPE measurement requirements, [c] telemetry requirements, and [d] the scaling of retrieval precision from the ground based actuals to the space based operations. For example, the ground based actual TIMS column precisions for retrieval from the SR data scale to space deployed TIMS column retrieval precisions for CO(=8.6%), H2O(=3.7%), CH4(=0.9%) and for albedo(=0.2%) on the GEO-CAPE minimum footprint. We'll also present the actuals, and the scaling to the GEO-CAPE case, for multi-layer CO and H2O retrieval from the combined SR and TIR data sets. The required aperture is quite small, 7.5 cm. We will also present a straight forward approach to expand the GEO-CAPE TIMS concept to additional spectral regions near 3.3, 3.6 and 9.6 um that will provide for multi-layer retrieval of tropospheric ozone, and for HCHO column. The approach adds relatively small mass, but

  20. Discussions about the Nature of Science in a Course on the History of Astronomy. (Spanish Title: Discusiones sobre la Naturaleza de la Ciencia en un Curso sobre Historia de la Astronomía.) Discussões sobre a Natureza da Ciência em um Curso sobre a História da Astronomia

    NASA Astrophysics Data System (ADS)

    Pires de Andrade, Victória Flório; L'Astorina, Bruno

    2010-07-01

    There are an increasing number of researches in science education that affirm the importance of discussions on the "nature of science" in basic education level as well as in teacher training. The history of science applied to education is a way to contextualize epistemological discussions, allowing both the understanding of scientific content and learning about science concepts. We present some reasonably consensual definitions on the nature of science that have been widely discussed by the academic community. We show also some episodes in the history of astronomy which can lead to discussions involving some aspects of the nature of science, and how they can do it. Hay un número creciente de investigaciones en la enseñanza de las ciencias que afirman la importancia de debates sobre la "naturaleza de la ciencia" en la educación básica y formación del profesorado. La historia de la ciencia aplicada a la educación es una manera de contextualizar los debates de la epistemología, lo que permite tanto la comprensión de los contenidos científicos como el aprendizaje de conceptos científicos. En esto trabajo, presentamos algunas definiciones bastante consensuales sobre la naturaleza de la ciencia que han sido ampliamente discutidas por la comunidad académica y mostramos cómo algunos episodios en la historia de la astronomía pueden llevar a discusiones sobre algunos aspectos de la naturaleza de la ciencia. Há um número crescente de pesquisas na área de ensino de ciências que afirmam a importância de discussões sobre a "natureza da ciência" na educação básica e na formação de professores. A história da ciência aplicada ao ensino é uma maneira de contextualizar discussões epistemológicas, permitindo tanto a compreensão de conteúdos científicos quanto o aprendizado de noções sobre as ciências. Neste trabalho apresentamos algumas definições razoavelmente consensuais sobre a natureza da ciência que foram amplamente discutidas pela

  1. Astronomy Teaching and Teachers Continuing Education: the Interdisciplinarity during a Total Lunar Eclipse. (Spanish Title: Enseñanza de la Astronomía y la Formación Continua de Profesores: la Interdisciplinariedad Durante un Eclipse Total de Luna.) Educação EM Astronomia E Formação Continuada de Professores: a Interdisciplinaridade Durante um Eclipse Lunar TOTAL

    NASA Astrophysics Data System (ADS)

    Langhi, Rodolfo

    2009-07-01

    This paper describes how 67 teachers from 23 cities, could awaken, in students, the scientific interest, using a natural astronomical phenomenon: a total lunar eclipse. Before and after of eclipse, meetings for continuing education were characterized by interdisciplinarity of astronomy and the importance of these observations. Working groups were formed by teachers and students, who organized the survey data, mobilizing the people in their cities. The results point ways about how to provide the scientific culture and the motivation to learn science in students, using approaches between the following communities: scientific, amateur and school. En este artículo se describe cómo 67 profesores de 23 ciudades, despertó el interés científico en los estudiantes mediante un fenómeno astronómico: un eclipse total de Luna. Antes y después del eclipse, reuniones para la formación continua se centraron en la interdisciplinariedad de la astronomía, y la importancia de las observaciones de este tipo de fenómeno. Profesores y estudiantes formaron grupos de trabajo para investigar datos durante el eclipse, con el participación de la comunidad en sus ciudades. Los resultados apuntan a las opciones que conducen a la cultura científica y la motivación para aprender la ciencia, utilizando las relaciones de los siguientes grupos: científicos, aficionados y la escuela. Este texto relata como 67 professores, provenientes de 23 cidades, puderam despertar, nos alunos, o interesse científico utilizando um fenômeno natural astronômico: um eclipse lunar total. O evento foi precedido e procedido por encontros de formação continuada, onde se caracterizou a interdisciplinaridade da astronomia e a importância das observações de fenômenos como estes. Grupos de trabalho foram formados por professores e alunos, que se organizaram para o levantamento conjunto de dados durante o fenômeno, além do envolvimento da comunidade em suas respectivas cidades. Os resultados apontam

  2. Essays on Eclipses, Transits and Occultations as Teaching Tools in the Introductory Astronomy College Course. (Spanish Title: Ensayos sobre Eclipses, Tránsitos y Ocultaciones Como Herramientas de Enseñanza en el Curso Universitario Introductorio a la Astronomía.) Ensaios sobre Eclipses, Trânsitos e Ocultações Como Ferramentas de Ensino em um Curso Universitário Introdutório de Astromomia

    NASA Astrophysics Data System (ADS)

    Dcruz, Noella L.

    2014-07-01

    estudiantes que escribieran dos ensayos cortos de tres que se proponían. Los ensayos contenían partes descriptivas y conceptuales. Los mismos estaban destinados a servir como herramientas de enseñanza. 62% de los 106 ensayos de 55 estudiantes obtuvo grados A, B o C. 21% de los 47 encuestados que respondieron al cuestionario posterior consideró que los ensayos aumentaron su interés por la astronomía. 49% de los encuestados consideró que los ensayos no eran educacionalmente útiles y que no deben ser propuestos de nuevo. Las respuestas escritas más comunes a nuestra encuesta indicaran que los estudiantes necesitan más orientación y una mejor preparación en la redacción de ensayos exitosos. Dado que los estudiantes encontraron las piezas conceptuales de los ensayos difíciles, en el futuro vamos a ofrecer actividades pertinentes antes de los plazos de redacción para ayudar a los estudiantes a crear ensayos de mayor calidad. Nós ocasionalmente incluímos projetos em nosso curso universitário introdutório centrado no aluno para permitir aos estudantes que pertencem às carreiras não científicas explorar alguns conceitos astronômicos em mais detalhes do que o normal. Tais projetos também enfatizam eventos astronômicos em curso ou futuros. Esperamos que os alunos se sintam mais interessados na astronomia através de projetos ligados a eventos astronômicos. No termo de Primavera de 2012 (EUA), propomos ensaios curtos focados em eclipses, trânsitos e ocultações para promover o raro trânsito de Vênus que ocorreu no dia 5 de junho de 2012. Pedimos aos alunos que escrevessem dois ensaios curtos dentre três que foram propostos. Os ensaios continham partes descritivas e conceituais. Eles foram feitos para servir como ferramentas de ensino. 62% de 106 ensaios de 55 alunos ganhou graus A, B ou C. 21% dos 47 entrevistados que responderam ao levantamento posterior sentiu que os ensaios aumentaram seu interesse na astronomia. 49% dos inquiridos consideraram que os

  3. Solar Physics Topics in High School: Analysis of a Course with Practical Activities at Dietrich Schiel Observatory. (Spanish Title: Temas de Física Solar Para Estudiantes de Escuelas Secundarias: un Análisis de un Curso con Enfoque Práctico en el Observatorio Dietrich Schiel.) Tópicos de Física Solar no Ensino Médio: Análise de um Curso com Atividades Práticas no Observatório Dietrich Schiel

    NASA Astrophysics Data System (ADS)

    Calbo Aroca, Silvia; Donizete Colombo, Pedro, Jr.; Celestino Silva, Cibelle

    2012-12-01

    algunos estudiantes sabían que un espectro puede estar formado por un prisma o red de difracción, la mayor parte de ellos desconocía la naturaleza de las líneas espectrales. A lo largo del curso, esta cuestión fue trabajada con un enfoque práctico mediante la observación del espectro solar y de las lámparas durante clases expositivas/dialogadas. Los resultados obtenidos en el curso mustran la importancia de los centros de ciencia como un apoyo en la educación formal. En este caso en particular, la Sala Solar del Observatorio Dietrich Schiel se destaca como un entorno favorable para la enseñanza de la física moderna en la escuela secundaria. Este trabalho analisa resultados obtidos em um curso sobre física solar para alunos do ensino médio promovido pelo Observatório Dietrich Schiel da USP. O curso foi elaborado pelos autores com a intenção de investigar concepções sobre o Sol, ensinar tópicos de física moderna relacionados ao Sol e conhecimentos gerais sobre o astro rei. A metodologia de coleta de dados consistiu em gravação em áudio e vídeo das aulas e das entrevistas semi-estruturadas, e respostas a questionários escritos. Os resultados mostraram que a maioria dos participantes concebeu o Sol como constituído por fogo e as manchas solares como buracos na superfície solar. Embora alguns alunos soubessem que um espectro pode ser formado por um prisma ou rede de difração, a maior parte deles desconhecia a natureza das linhas espectrais. Ao longo do curso, este tema foi trabalhado com uma abordagem prática com observação do espectro solar e de lâmpadas e em aulas expositivo-dialogadas. Os resultados obtidos no curso apontam para a importância dos centros de ciências como parceiros da educação formal. Neste caso específico, a Sala Solar do Observatório Dietrich Schiel é um ambiente propício para o ensino de física moderna no ensino médio.

  4. The Practice of Research of a Basic Education Teacher Involving Mental Models of the Phases of the Moon and Eclipses. (Spanish Title: La Práctica de Investigación de un Maestro de Educación BÁsica con El Uso de los Modelos Mentales de Las Fases de la Luna Y Eclipses.) A Prática de Pesquisa de um Professor do Ensino Fundamental Envolvendo Modelos Mentais de Fases da Lua e Eclipses

    NASA Astrophysics Data System (ADS)

    Pessôa Queiroz, Glória; Jubitipan Borges de Sousa, Carlos; Auxiliadora Delgado Machado, Maria

    2009-12-01

    docente. La formación de grupos interinstitucionales para la planificación de la acción y la investigación ha resultado productiva para el trabajo de construcción de conocimiento de apoyo a los procesos educativos en la escuela, mientras que la universidad enriquece su colección de experiencias validadas, considerando los resultados de la educación inicial y continua de maestros. La participación activa del maestro en un grupo de investigación en la universidad lo llevó a reflexiones sobre los posibles caminos didácticos que pueden ser descriptos, analizados y comunicados a los demás docentes. La construcción de una pedagogía propia, que tuvo en cuenta los modelos mentales de los estudiantes sobre los temas básicos de astronomía, y los cambios desarrollados a partir de las lecciones que enseñó, trajeron consecuencias de largo alcance sobre la pedagogía adoptada por el maestro, que ahora incorpora una nueva visión de la ciencia y formas alternativas al diálogo con los estudiantes, los componentes esenciales para un investigador en Educaciónen Ciencias. A inclusão do professor da escola básica no universo da pesquisa é questão controvertida e em pleno debate no meio acadêmico. A oportunidade de trabalho coletivo que incorporou professores de uma escola municipal no Rio de Janeiro a um grupo de ensino de Física da universidade nos possibilitou vislumbrar a ressignificação da função de um professor de Ciências (co-autor deste trabalho) por ele próprio, agora passando a incluir a pesquisa sobre a construção de conhecimento pelos alunos em sua prática como docente. A formação de grupos interinstitucionais para o planejamento de ações e de pesquisas tem-se mostrado produtiva para um trabalho de construção de conhecimentos a fim de subsidiar processos educativos na escola, ao mesmo tempo em que a universidade enriquece seu acervo de experiências validadas criticamente, podendo considerar seus resultados na formação inicial e

  5. Evaluacion de la Interaccion Adulto-Nino en Aulas Pre-escolares de Concepcion, Chile. [Evaluation Adult-Child Interaction in Preschool Classrooms of Concepcion, Chile.

    ERIC Educational Resources Information Center

    Mathiesen De G., Maria Elena; Herrera G., Maria Olivia; Villalon B., Malva; Suzuky S., Emy

    2000-01-01

    Presents findings from investigation of the validity of the Arnett Caregiver Interaction Scale, CIS (1989), in preschools in Concepcion, Chile. Demonstrates the reliability and validity of the scale to evaluate the interaction of the childhood educator with young children, suggesting changes to the scale. Notes differences found for school type.…

  6. The Portugal Project: Adult Education in a Socio-economic Perspective. Paper for the Course, "Curso sobre Educacao de Adultos." Document No. 1.

    ERIC Educational Resources Information Center

    Erasmie, Thord

    Education is one of the major problems connected with the economic and social distribution of the total resources of the world. Examples of the educational gap between rich and poor countries can be seen by statistical comparisons between Peru and Czechoslavakia and between Guatemala and Denmark which show how unevenly educational resources are…

  7. Revista interamericana de educacion de adultos, volumen 12, numero 1, 2 = International Review of Adult Education, Volume 12, Numbers 1 and 2.

    ERIC Educational Resources Information Center

    Benavides, Luis G., Ed.

    1989-01-01

    Two issues of this journal on adult education contain articles on the following: administration, adult education, and democracy; native cultural diversity, cultural differences, and education; a profile of a popular educator; institutionalization of adult education; rural education in Mexico; projects in adult education; the necessity of and…

  8. Modelo Pedagogico de Educacion Primaria para Adultos: Guia General de Apoyo para el Estudiante de Primaria (Pedagogical Model for Adult Primary Education: General Guide for the Student).

    ERIC Educational Resources Information Center

    Instituto Nacional para la Educacion de los Adultos, Mexico City (Mexico).

    This book, part of a Mexican series of instructional materials, is directed toward people over the age of 15 who are interested in beginning, continuing or finishing their basic education. It explains the pedagogical model developed for adult education in Mexico based on the following features: (1) the content of the textbooks must be useful for…

  9. La formacion civica y la educacion de adultos; discurso de inauguracion y recomendaciones (Adult Training for Citizenship and Education; Opening Address and Recommendations).

    ERIC Educational Resources Information Center

    El Maestro, Mexico, 1970

    1970-01-01

    This document is an English-language abstract (approximately 1,500 words) of the Mexican Education Minister's remarks at a conference for adult education. He stated that educational reform was part of a far reaching plan for social reform; he characterized civic training as an all-sector task, transcending confinement to the classroom and…

  10. Educacion de Adultos en America Latina. Estudio Bibliografico. Serie Bibliografica # 3 (Adult Education in Latin America: Bibliographical Study. Bibliographical Series # 3).

    ERIC Educational Resources Information Center

    Schlaen, Norah

    This analytical bibliography describes a group of selected documents that examine the current status and extent of development of adult education in Latin America. Documents were selected for inclusion based upon their focus on and concern for international and national goals and needs of adult education programs and for distribution to countries…

  11. Providing Meaningful Learning for Students of the Sixth Grade of Middle School: a Study on the Moon Phases. (Breton Title: Propiciando Aprendizagem Significativa Para Alunos do Sexto Ano do Ensino Fundamental: um Estudo sobre as Fases da Lua.) Propiciando el Aprendizaje Significativo Para Alumnos del Sexto Nivel de la Educación General Básica: un Estudio sobre Las Fases de la Luna

    NASA Astrophysics Data System (ADS)

    Darroz, Luiz Marcelo; Samudio Pérez, Carlos Ariel; da Rosa, Cleci Werner; Heineck, Renato

    2012-07-01

    We relate in this article a didactic experience studying the moon phases with a group of middle school students of a private school of the municipality of Passo Fundo, RS. Based on David Ausubel's Meaningful Learning Theory, we have sought to develop a proposal following a didactic model which simulates the phases of the Moon, as based on the previous conceptions of the students. The signs of learning were evidenced by means of memory registries of the activity. From the obtained results we believe that the proposal achieved its goals, since the students were able to identify, differentiate and transfer the phenomenon of the moon phases to new contexts. Thus, it is concluded that a methodology focused on a meaningful content for the students is fundamental to the construction and genuine grasping of what is being learned. Neste artigo, relata-se uma experiência didática de estudo das fases da Lua com uma turma do 6° ano do Ensino Fundamental, de uma escola privada do município de Passo Fundo, RS. Tendo como fundamentação teórica a Teoria da Aprendizagem Significativa de David Ausubel, buscou-se desenvolver a proposta a partir de um modelo didático que simula as fases da Lua e com base nas concepções prévias dos estudantes. Os indícios da aprendizagem foram constatados através de registros de memórias da atividade. Pelos resultados apresentados, acredita-se que a proposta alcançou seus objetivos, uma vez que os estudantes conseguiram identificar, diferenciar e transferir o fenômeno das fases da Lua para novos contextos. Assim, conclui-se que uma metodologia com enfoque em um conteúdo significativo ao estudante é fundamental para a construção e compreensão genuína do que está sendo aprendido. En este artículo se relata una experiencia didáctica de estudio de las fases de la Luna con una clase de 6º año de la educación general básica de una escuela privada del municipio de Passo Fundo, RS. Teniendo como fundamentación teórica la Teor

  12. The Practice of Research of a Basic Education Teacher Involving Mental Models of the Phases of the Moon and Eclipses. (Spanish Title: La Práctica de Investigación de un Maestro de Educación BÁsica con El Uso de los Modelos Mentales de Las Fases de la Luna Y Eclipses.) A Prática de Pesquisa de um Professor do Ensino Fundamental Envolvendo Modelos Mentais de Fases da Lua e Eclipses

    NASA Astrophysics Data System (ADS)

    Pessôa Queiroz, Glória; Jubitipan Borges de Sousa, Carlos; Auxiliadora Delgado Machado, Maria

    2009-12-01

    docente. La formación de grupos interinstitucionales para la planificación de la acción y la investigación ha resultado productiva para el trabajo de construcción de conocimiento de apoyo a los procesos educativos en la escuela, mientras que la universidad enriquece su colección de experiencias validadas, considerando los resultados de la educación inicial y continua de maestros. La participación activa del maestro en un grupo de investigación en la universidad lo llevó a reflexiones sobre los posibles caminos didácticos que pueden ser descriptos, analizados y comunicados a los demás docentes. La construcción de una pedagogía propia, que tuvo en cuenta los modelos mentales de los estudiantes sobre los temas básicos de astronomía, y los cambios desarrollados a partir de las lecciones que enseñó, trajeron consecuencias de largo alcance sobre la pedagogía adoptada por el maestro, que ahora incorpora una nueva visión de la ciencia y formas alternativas al diálogo con los estudiantes, los componentes esenciales para un investigador en Educaciónen Ciencias. A inclusão do professor da escola básica no universo da pesquisa é questão controvertida e em pleno debate no meio acadêmico. A oportunidade de trabalho coletivo que incorporou professores de uma escola municipal no Rio de Janeiro a um grupo de ensino de Física da universidade nos possibilitou vislumbrar a ressignificação da função de um professor de Ciências (co-autor deste trabalho) por ele próprio, agora passando a incluir a pesquisa sobre a construção de conhecimento pelos alunos em sua prática como docente. A formação de grupos interinstitucionais para o planejamento de ações e de pesquisas tem-se mostrado produtiva para um trabalho de construção de conhecimentos a fim de subsidiar processos educativos na escola, ao mesmo tempo em que a universidade enriquece seu acervo de experiências validadas criticamente, podendo considerar seus resultados na formação inicial e

  13. Learning about the Sky from the Environment: An Experience Working Along One Year with Students of Elementary Education. (Spanish Title: Aprendiendo sobre EL Cielo Desde el Entorno: Una Experiencia Trabajando Durante un Año Junto a Estudiantes del Primario.) Aprendendo sobre o Céu a Partir do Entorno: Uma Experiência de Trabalho ao Longo de um Ano com Alunos de Ensino Fundamental

    NASA Astrophysics Data System (ADS)

    Longhini, Marcos Daniel; Gomide, Hanny Angeles

    2014-12-01

    percepción limitada que los estudiantes tienen de su alrededor la cual, sin embargo, se expandió debido a las actividades llevadas a cabo, sobre todo en relación con la Luna. Trabajar con medidas sistemáticas revela el manejo cuidadoso de los datos para que sean comprensibles para los estudiantes, así como el trabajo con las sombras para que comprendan primero como se forman estas para después trabajarlas en Astronomía. Por último, llegamos a la conclusión de que el proceso desarrollado consistió en una etapa inicial de una obra que debe ser profundizado en los años posteriores de la formación de estos estudiantes. Projeto de pesquisa desenvolvido com 95 alunos do 6º ano do Ensino Fundamental de uma escola pública estadual de Uberlândia, Minas Gerais. Foi um trabalho contínuo, de fevereiro a dezembro de 2013, o qual levou os alunos a participarem de atividades de observação do entorno, dentre ele, o céu, analisando as mudanças ocorridas. Focamos no estudo das variações de temperaturas, chuvas, duração do dia, variações do tamanho das sombras e mudanças nos aspectos da Lua. Nosso foco de análise centrou-se em discutir os conhecimentos que os referidos alunos tinham acerca dos temas indicados no início e ao término da implementação da proposta. Os resultados mostraram a percepção limitada que os estudantes possuem de seu entorno, todavia, ampliada em função das atividades desenvolvidas, principalmente no que se refere à Lua. O trabalho com medidas sistemáticas revela o cuidado no tratamento dos dados para que eles se tornem compreensíveis aos alunos, assim como o trabalho com as sombras sinaliza para que os alunos primeiramente compreendam como as sombras são formadas para depois trabalhar isso em Astronomia. Por fim, concluímos que o processo vivido constituiu-se em uma etapa inicial de um trabalho que deve ser estimulado para os anos subsequentes da formação desses alunos.

  14. Mild steels coated with 14% manganese covered electrodes (E7-UM-200-K and E1-UM-350): Phenomena at the steel-coating interface

    SciTech Connect

    Molleda, F. . E-mail: fmolleda@etsin.upm.es; Mora, J.; Molleda, F.J.; Carrillo, E.; Mora, E.; Mellor, B.G.

    2006-12-15

    In this work the authors have studied the phenomena in the interface of the coating made on soft carbon steel with electrodes with a high content of manganese. The study has been done with scanning electron microscope and X-rays mapping images. These images show how the alloy elements are distributed in each of the constituent elements presented in the interface, and the nature of these constituents. These results have allowed us to verify that many of the problems that arise in homogeneous joints, as such localised corrosion, low interface resistance, etc., happened, precisely in these regions. As a help to determine the nature of the constituent elements, microhardness measurements have also been made.

  15. Comparing the use of 4.6 um lasers versus 10.6 um lasers for mitigating damage site growth on fused silica surfaces

    SciTech Connect

    Yang, S T; Matthews, M J; Elhadj, S; Cooke, D; Guss, G M; Draggoo, V G; Wegner, P J

    2010-10-21

    The advantage of using mid-infrared (IR) 4.6 {micro}m lasers, versus far-infrared 10.6 {micro}m lasers, for mitigating damage growth on fused silica is investigated. In contrast to fused silica's high absorption at 10.6 {micro}m, silica absorption at 4.6 {micro}m is two orders of magnitude less. The much reduced absorption at 4.6 {micro}m enables deep heat penetration into fused silica when it is heated using the mid-IR laser, which in turn leads to more effective mitigation of damage sites with deep cracks. The advantage of using mid-IR versus far-IR laser for damage growth mitigation under non-evaporative condition is quantified by defining a figure of merit (FOM) that relates the crack healing depth to laser power required. Based on our FOM, we show that for damage cracks up to at least 500 {micro}m in depth, mitigation using a 4.6 {micro}m mid-IR laser is more efficient than mitigation using a 10.6 {micro}m far-IR laser.

  16. Comparison of atmospheric transmittance measurements in the 3- to 5-um and 8- to 12-um spectral regions with MODTRAN: considerations for long near-horizontal path geometries

    NASA Astrophysics Data System (ADS)

    Ratkowski, Anthony J.; Anderson, Gail P.; Chetwynd, James H.; Nadile, Richard M.; Devir, Adam D.; Conley, T. D.

    1998-01-01

    Radiance measurements conducted during tropospheric operations to detect objects on the Earth's surface from a manned aircraft or from an unmanned airborne vehicle (UAV) will involve long, near-horizontal viewing geometries. The computer code MODTRAN is widely used for the prediction of the propagation of infrared radiation through the lower atmosphere. Consequently, we have undertaken to test the predictions of MODTRAN for the 3 - 5 and 8 - 12 micron spectral regions under mid-Eastern desert conditions.

  17. Properties of Interstellar Medium In Infrared-bright QSOs Probed by [O i] 63 um and [C ii] 158 um Emission Lines

    NASA Astrophysics Data System (ADS)

    Zhao, Yinghe; Yan, Lin; Tsai, Chao-Wei

    2016-06-01

    We present a study of the interstellar medium (ISM) in the host galaxies of nine QSOs at 0.1 < z < 0.2 with black hole masses of 3× {10}7 {M}ȯ to 3× {10}9 {M}ȯ based on the far-IR spectroscopy taken with Herschel Space Observatory. We detect the [O i] 63 μm ([C ii] 158 μm) emission in 6 (8) out of 8 (9) sources. Our QSO sample has far-infrared luminosities ({L}{{FIR}}) ˜ several times {10}11{L}ȯ . The observed line-to-{L}{{FIR}} ratios ({L}[{{O}{{I}}]63μ {{m}}}/{L}{{FIR}} and {L}[{{C}{{II}}]}/{L}{{FIR}}) are in the ranges of 2.6 × 10‑4 to 10‑2 and 2.8 × 10‑4 to 2 × 10‑3, respectively (including upper limits). These ratios are comparable to the values found in local ULIRGs, but higher than the average value published so far for z\\gt 1 IR-bright QSOs. One target, W0752+19, shows an additional broad velocity component (˜720 km s‑1) and exceptionally strong [O i] 63 μm emission with {L}[{{O}{{I}}]63μ {{m}}}/{L}{{FIR}} of 10‑2, an order of magnitude higher than the average value found among local (U)LIRGs. Combining with the analyses of the Sloan Digital Sky Survey optical spectra, we conclude that the [O i] 63 μm emission in these QSOs is unlikely excited by shocks. We infer that the broad [O i] 63 μm emission in W0752+19 could arise from the warm and dense ISM in the narrow-line region of the central active galactic nucleus. Another possible explanation is the existence of a dense gas outflow with {n}{{H}}˜ {10}4 cm‑3, where the corresponding broad [C ii] emission is suppressed. Based on the far-IR [O i] and [C ii] line ratios, we estimate constraints on the ISM density and UV radiation field intensity of {n}{{H}}≲ {10}3.3 cm‑3 and {10}3\\lt {G}0≲ {10}4.2, respectively. These values are consistent with those found in local Seyfert 1 ULIRGs. In contrast, the gas with broad velocity width in W0752+19 has {n}{{H}}≳ {10}4.3 cm‑3 and {G}0\\gt {10}4. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.

  18. On Ensino da Astronomia no Ensino Médio sob Diferentes Abordagens Metodológicas

    NASA Astrophysics Data System (ADS)

    Voelzke, Marcos Rincon; Albrecht, Evonir

    2011-12-01

    O presente trabalho, sobre a intervenção de metodologias de ensino, foi desenvolvido na Escola Estadual Colônia dos Pescadores, na cidade de Caraguatatuba - SP, em três turmas do terceiro ano do Ensino Médio, perfazendo um total de 119 educandos, entre 16 e 19 anos. Antes de iniciar-se a intervenção, um questionário de vinte perguntas objetivas e dissertativas foi desenvolvido, aplicado pelo professor da classe, que ministrou as aulas correspondentes. Este questionário foi o mesmo em todas as três classes com o objetivo de diagnosticar o conhecimento prévio dos alunos sobre Astronomia. Começando a intervenção nas turmas, o professor envolvido usou três diferentes metodologias de ensino: (A) em forma de seminários, elaborados e apresentados pelos alunos, nos quais o professor fazia apenas as intervenções necessárias, (B) na forma tradicional, com a ajuda de multimídia para o desenvolvimento das aulas e a terceira (C) a tradicional, fazendo uso exclusivo de lousa e giz. No final do trabalho os alunos responderam o mesmo questionário novamente, de modo que os três métodos utilizados puderam ser comparados. Os resultados apresentados após a intervenção foram melhores que os resultados iniciais indicando a ocorrência de uma aprendizagem significativa. Quando os estudantes foram inicialmente questionados sobre quantos planetas existem no nosso sistema solar, a classe A obteve 39% de respostas certas, a classe B 48% e a classe C 46%, mas após o desenvolvimento das atividades, as classes obtiveram respectivamente 94%, 97 % e 90% de aproveitamento. No término do bimestre, foi sugerido aos educandos que elaborassem uma história em quadrinhos, a qual serviu para averiguar se os conceitos inicialmente observados foram alterados e se novos foram agregados. A análise das histórias foi dividida em três partes: Criatividade; Temas abordados; Emprego correto dos conceitos estudados. Ao final quatorze histórias foram confeccionadas. O aprendizado

  19. A Influência da Escola e da Mídia na Obtenção dos Conhecimentos Astronômicos

    NASA Astrophysics Data System (ADS)

    da Cunha, W. S.; Voelzke, M. R.; Amaral, L. H.

    2006-08-01

    O universo em que vivemos possui segredos jamais imaginados pelo homem, fruto da pequena proporção que ocupamos diante de um cosmos infinito. A astronomia funciona como um instrumento que sacia a sede humana em desvendar esses segredos, estudando as galáxias, quasares, pulsares além da existência de todos os elementos que preenchem o espaço cósmico, o vácuo, não mais vazio como se pensou em outros tempos. A mídia explora esse campo de forma mística e também científica. A difusão adequada e dentro dos padrões educacionais vigentes, de conceitos astronômicos, se faz necessária, devido sua presença nos conteúdos escolares, centros de ciência e na mídia, de modo geral. A reforma do Currículo Básico da Escola Pública da maioria dos Estados brasileiros introduziu conceitos astronômicos desde a pré-escola até o Ensino Médio. Num estudo realizado com 1.032 alunos do Ensino Médio de seis escolas estaduais, revelou-se através da aplicação de um questionário que abordava conheciment os básicos em astronomia, como estes foram adquiridos e qual era a infra-estrutura oferecida pela escola: para 66,2% dos entrevistados o professor já fez alguma apresentação a respeito de astronomia. O presente estudo revelou também que 44,5% dos alunos entrevistados adquiriram seus conhecimentos astronômicos na escola, 28,1% através da televisão e 27,4% afirmaram que seus conhecimentos foram obtidos através de outros tipos de mídia (internet, filmes e revistas). Embora o estudo revele claramente que há certo equilíbrio na forma em que os alunos obtiveram seus conhecimentos astronômicos, a mídia ainda explora e muitas vezes desperta o interesse pela astronomia com assuntos que não fazem parte de nosso cotidiano como, por exemplo, o homem na Lua, os projetos espaciais e a primeira viagem de um astronauta brasileiro no espaço. Porém, em certos casos, a mídia pode promover conhecimentos incompletos ou mesmo equivocados sobre os conceitos que envolvam

  20. Synchronous and asynchronous multiplexer circuits for medical imaging realized in CMOS 0.18um technology

    NASA Astrophysics Data System (ADS)

    Długosz, R.; Iniewski, K.

    2007-05-01

    Multiplexers are one of the most important elements in readout front-end ASICs for multi-element detectors in medical imaging. The purpose of these ASICs is to detect signals appearing randomly in many channels and to collect the detected data in an ordered fashion (de-randomization) in order to send it to an external ADC. ASIC output stage functionality can be divided into two: pulse detection and multiplexing. The pulse detection block is responsible for detecting maximum values of signals arriving from the shaper, sending a flag signal indicating that the peak signal has been detected and storing the pulse in an analog memory until read by ADC. The multiplexer in turn is responsible for searching for active flags, controlling the channel that has detected the peak signal and performing reset functions after readout. There are several types of multiplexers proposed in this paper, which can be divided into several classes: synchronous, synchronized and asynchronous. Synchronous circuits require availability of the multiphase clock generator, which increases the power dissipation, but simultaneously provide very convenient mechanism that enables unambiguous choice of the active channel. This characteristics leads to 100% effectiveness in data processing and no data loss. Asynchronous multiplexers do not require clock generators and because of that have simpler structure, are faster and more power efficient, especially when data samples occur seldom at the ASIC's inputs. The main problem of the asynchronous solution is when data on two or more inputs occur almost at the same time, shorter than the multiplexer's reaction time. In this situation some data can be lost. In many applications loss of the order of 1% of the data is acceptable, which makes use of asynchronous multiplexers possible. For applications when the lower loss is desirable a new hierarchy mechanism has been introduced. One of proposed solutions is a synchronized binary tree structure, that uses many simple asynchronous clock generators. This circuit joins advantages of synchronous and asynchronous solutions resulting in low power dissipation, high speed of operation and 100% effectiveness.

  1. High-performance 0.25-um CMOS technology for fast SRAMs

    NASA Astrophysics Data System (ADS)

    Hayden, James D.; McNelly, T. F.; Perera, Asanga H.; Pfiester, Jim R.; Subramanian, C. K.; Thompson, Matthew A.

    1996-09-01

    A high performance 0.25 micrometers CMOS process has been developed for fast static RAMs. This technology features retrograde wells, shallow trench isolation scalable to a 0.45 micrometers active pitch, surface channel 0.25 micrometers NMOS and PMOS transistors with a 55 angstroms nitrided gate oxide providing drive currents of 630 and 300 (mu) A/micrometers respectively at off-leakages of 10 pA/micrometers , overgated TFTs with an on/off ratio greater than 6(DOT)105, stacked capacitors for improved SER protection, five levels of polysilicon planarized by chemical-mechanical polishing with two self-aligned interpoly contacts, 0.35 micrometers contacts and a 0.625 metal pitch. In this technology, a triple well structure was used for SER protection. High energy retrograde wells were integrated with shallow trench isolation and epi providing excellent interwell isolation for both leakage and latch-up down to n+/p+ spaces of 0.60 micrometers . PMOS transistors were scaled to a physical gate length of 0.1 micrometers while maintaining excellent short channel characteristics. A split word-line bitcell was scaled to 1.425 micrometers X 2.625 micrometers equals 3.74 micrometers 2 using 0.25 micrometers rules. A tungsten interpoly plug was used to connect the PMOS TFT loads to the underlying NMOS latch gates without a parasitic diode or dopant interdiffusion, connecting 3 polysilicon layers with self-aligned isolation from an intervening polysilicon layer used as a local interconnect. With this plug, TFT drive currents were greatly improved, particularly at low voltages and the memory nodes pulled to the fully supply voltage. Functional 0.25 micrometers bitcells were demonstrated and with an LDD resistor it was possible to double the cell stability. Bitcell simulation was used to demonstrate that a 4T bitcell will be stable at 2.5 V but that a word-line boost will be required for 1.8 V operation.

  2. High-reliability nonhermetic 1.3-um InP-based uncooled lasers

    NASA Astrophysics Data System (ADS)

    Chand, Naresh; Osenbach, John W.; Evanosky, T. L.; Comizzoli, Robert B.; Tsang, Won-Tien

    1996-01-01

    We report the first uncooled non-hermetic 1.3 micrometer InP-based communication lasers that have reliability comparable to their hermetically packaged counterparts for possible applications in fiber in the loop and cable TV. The development of reliable non-hermetic semiconductor lasers would not only lead to the elimination of the costs specifically associated with hermetic packaging but also lead the way for possible revolutionary low cost optoelectronic packaging technologies. We have used Fabry-Perot capped mesa buried heterostructure (CMBH) uncooled lasers with both bulk and MQW active regions grown on n- type InP substrates by VPE and MOCVD. We find that the proper dielectric facet passivation is the key to obtain high reliability in a non-hermetic environment. The passivation protects the laser from the ambient and maintains the proper facet reflectivity to achieve desired laser characteristics. The SiO facet passivation formed by molecular beam deposition (MBD) has resulted in lasers with lifetime well in excess of the reliability goal of 3,000 hours operation at 85 degrees Celsius/90% RH/30 mA aging condition. Based on extrapolations derived experimentally, we calculate a 15 year average device hazard rate of less than 300 FITs (as against the desired 1,500 FITs) for the combination of thermal and humidity induced degradation at an ambient condition of 45 degrees Celsius/50% RH. For comparison, the average hazard rate at 45 degrees Celsius and 15 years of service is approximately 250 FITs for hermetic lasers of similar construction. A comparison of the thermal only degradation (hermetic) to the thermal plus humidity induced degradation (non-hermetic) indicates that the reliability of these nonhermetic lasers is controlled by thermal degradation only and not by moisture-induced degradation. In addition to device passivation for a non-hermetic environment, MBD-SiO maintains the optical, electrical and mechanical properties needed for high-performance laser systems.

  3. Implementation of i-line lithography to 0.30 um design rules

    NASA Astrophysics Data System (ADS)

    Kim, KeunYoung; Kim, Hung-Eil; Lee, Il-Ho; Kim, Jin-Soo; Chun, Jun-Sung; Hur, Ikboum; Moon, Seung-Chan; Baik, Ki-Ho; Choi, Soo-Han

    1995-05-01

    The optical lithography is extending its life by combining high numerical aperture (NA) optics and shorter wavelength. The shorter wavelength lithography has required the new developments of related technologies. In particular, DUV resists require an entirely different resist chemistry. Much progress has been demonstrated in the field of transparent chemically amplified resists with high sensitivity. However, this DUV lithography ((lambda) equals 248 nm) has been delayed for mass production due to their limitations, such as (i) delay time effects, (ii) high cost ownership due to expensive resist materials and laser maintenance, and (iii) critical dimension (CD) variation over topography caused by multireflection of topographic features. On the other hand, i- line lithography ((lambda) equals 365 nm) has apparently been applied to 64M DRAM of 0.35 micrometers design rule, and attempted to 0.30 micrometers technology which corresponds to 2nd generation 64M DRAM or 1st generation 256 M DRAM. It might be achieved by combination of off-axis illumination (OAI), phase shift mask (PMS) and advanced resist process technique of i-line lithography. Therefore, i-line lithography can be more practical method rather than DUV lithography for the mass production. In this paper, we have optimized the i-line lithographic techniques for the various pattern shape and density for 0.30 micrometers design rule. Optimum duty ratio was tried to find for line and space, contact hole patterns. The basic rule is to keep the minimum Cr width over 0.30 micrometers mask. OAI have been applied to get higher contrast of line and space, and even contact hole patterns, and achieve good pattern fidelities of island patterns. By the implementation of OAI, process latitudes were greatly improved compared to that of conventional techniques. In order to optimize the process over the actual topography, optimum numerical aperture (NA) and aperture of the OAI were selected. In conclusion, 0.30 micrometers design rule device was successfully fabricated by optimizing the advanced i-line lithographic techniques.

  4. Process control for 0.25 um GaAs microwave monolithic integrated circuits

    NASA Astrophysics Data System (ADS)

    Hudgens, Rick D.; Meyers, Shirley; Small, Bret A.; Salzman, Keith; Rhine, David; Class, Randy

    1994-05-01

    Gallium arsenide metal semiconductor field effect transistors (GaAs MESFETs) are used in analog microwave monolithic integrated circuits (MMICs) because of their high frequency response. Common applications for MMICs include low noise and power amplifiers for use in satellite communication and missile guidance systems. The performance of MESFETs is improved with smaller gate lengths, but to consistently achieve the highest performance, control methods must be in place for the critical processes. Gate length control is the key parameter in maintaining the rf performance and a lack of gate pinch off is the major yield loss category. This paper describes the process and the tools that Texas Instruments uses to monitor the critical parameters. It also describes the control methods and reviews the major contributors to variations in the process.

  5. A Catalog of 1.5273 um Diffuse Interstellar Bands Based on APOGEE Hot Telluric Calibrators

    NASA Astrophysics Data System (ADS)

    Elyajouri, M.; Monreal-Ibero, A.; Remy, Q.; Lallement, R.

    2016-08-01

    High resolution stellar spectroscopic surveys provide massive amounts of diffuse interstellar bands (DIBs) measurements. Data can be used to study the distribution of the DIB carriers and those environmental conditions that favor their formation. In parallel, recent studies have also proved that DIBs extracted from stellar spectra constitute new tools for building the 3D structure of the Galactic interstellar medium (ISM). The amount of details on the structure depends directly on the quantity of available lines of sight. Therefore there is a need to construct databases of high-quality DIB measurements as large as possible. We aim at providing the community with a catalog of high-quality measurements of the 1.5273 μm DIB toward a large fraction of the Apache Point Observatory Galactic Evolution Experiment (APOGEE) hot stars observed to correct for the telluric absorption and not used for ISM studies so far. This catalog would complement the extensive database recently extracted from the APOGEE observations and used for 3D ISM mapping. We devised a method to fit the stellar continuum of the hot calibration stars and extracted the DIB from the normalized spectrum. Severe selection criteria based on the absorption characteristics are applied to the results. In particular limiting constraints on the DIB widths and Doppler shifts are deduced from the H i 21 cm measurements, following a new technique of decomposition of the emission spectra. From ∼16,000 available hot telluric spectra we have extracted ∼6700 DIB measurements and their associated uncertainties. The statistical properties of the extracted absorptions are examined and our selection criteria are shown to provide a robust dataset. The resulting catalog contains the DIB total equivalent widths, central wavelengths and widths. We briefly illustrate its potential use for the stellar and interstellar communities.

  6. VizieR Online Data Catalog: Chamaeleon I 870um sources (Belloche+, 2011)

    NASA Astrophysics Data System (ADS)

    Belloche, A.; Schuller, F.; Parise, B.; Andre, P.; Hatchell, J.; Jorgensen, J. K.; Bontemps, S.; Weiss, A.; Menten; K. M.; Muders, D.

    2011-01-01

    Table 2 lists the sources extracted with GAUSSCLUMPS from the filtered 870 micron continuum emission map of Chamaeleon I obtained with the bolometer camera LABOCA at the APEX telescope. These sources are listed in the order in which they were found by GAUSSCLUMPS, i.e. roughly in order of decreasing peak flux density. The 870 micron dust continuum emission map of the Chamaeleon I molecular cloud is available in FITS format. The data were obtained with the bolometer camera LABOCA at the APEX telescope. They were calibrated, reduced, co-added, gridded, smoothed to an effective angular resolution of 21.2" (FWHM), and written in FITS format with the BoA software. The flux density unit is Jy/21.2"-beam. The coordinates are equatorial (J2000) and the offsets are in RADIO projection. (6 data files).

  7. VizieR Online Data Catalog: Chamaeleon III 870um sources maps (Belloche+, 2011)

    NASA Astrophysics Data System (ADS)

    Belloche, A.; Parise, B.; Schuller, F.; Andre, P.; Bontemps, S.; Menten, K. M.

    2011-06-01

    The 870 micron dust continuum emission map of the Chamaeleon III molecular cloud displayed in Fig. 2 is available at CDS in FITS format. The data were obtained with the bolometer camera LABOCA at the APEX telescope. They were calibrated, reduced, co-added, gridded, smoothed to an effective angular resolution of 21.2" (FWHM), and written in FITS format with the BoA software. The flux density unit is Jy/21.2"-beam. The coordinates are equatorial (J2000) and the offsets are in RADIO projection. (1 data file).

  8. Earth's spectral albedo from 0.5 to 4.4 um

    NASA Astrophysics Data System (ADS)

    Montanes-Rodrig, P.; Palle, E.; Goode, P. R.; Koonin, S. E.

    2005-12-01

    We have analyzed spectroscopic earthshine data to determine Earth's nightly spectral albedos covering the visible, near and middle infrared spectral ranges. Observations in the visible were undertaken from Palomar Observatory with the spectrograph in the Palomar 60" telescope and with the echelle spectrograph of the InfraRed Telescope Facility (IRTF) on Mauna Kea in Hawaii. The observing runs were chosen near the quarter moon to reduce the background glow produced by the moonshine (bright side of the Moon). Although observations were taken on different nights, the similarity of lunar phases and comparable cloud cover conditions for the monitored part of the Earth's surface, allow us to derive, for the first time, an apparent albedo of the Earth covering the entire spectral range from 0.5 to 4.4 microns.

  9. 1.55 um aluminum gallium indium arsenide strained MQW laser diodes

    NASA Astrophysics Data System (ADS)

    Yang, Chi

    At the 1.55 mum eye-safe, telecommunications operating wavelength, semiconductor diode lasers must have low threshold currents and operate at high temperatures without thermoelectric coolers. Existing diode lasers in this wavelength range based on the GaInAsP/InP materials system are very sensitive to operating temperature. To obtain high temperature, high power 1.55 mum semiconductor diode lasers, the AlGaInAs/InP materials system with strained quantum well (QW) active regions was investigated with the goal of improving temperature performance. A set of lasers with active regions consisting of different numbers of QWs (2 to 4) and different QW strains (1.2% and 1.6%) were designed taking into account the quaternary alloy bandgap of AlGaInAs, the effect of strain on the bandgap, and the quantum size effects within the QW. The active region growth temperature was optimized using photoluminescence intensity. The wafers were first processed into broad-area lasers and measured under pulsed injection. The characteristic threshold current temperature, T0, for all AlGaInAs lasers was higher (60-70 K) than for GaInAsP lasers. No strong dependence of temperature parameters on strain was observed, while properties varied significantly with the number of QWs. With more QWs, both internal efficiency and T0 increases, but internal loss increases, reducing the characteristic temperature of the differential efficiency T1. The results show that uncooled laser operation at 1.55 mum is very promising with strained AlGaInAs QWs. Ridge waveguide devices demonstrated low threshold and high output power as well as good temperature performance under continuous wave operation. Devices with different ridge heights were fabricated from one wafer and their performance was compared. It was found that current spreading was significant in these devices and a simple current density-versus-applied voltage analysis was developed to determine the spreading factor. The analysis shows that the current spreading was not effectively limited until etching went below the doped cladding layer. A recombination coefficient analysis was performed to investigate the effect of strain on Auger recombination predicted by theory. An indirect method to infer both the nonradiative recombination coefficient and the Auger recombination coefficient was initially used. The measured values of the recombination coefficients were consistent with theoretical predictions and measurements based on other material systems. The Auger recombination was lower than expected, indicating that Auger recombination is reduced in these strained QWs. To understand the carrier dynamics, impedance measurements were carried out for the first time in AlGaInAs strained QW lasers. A small-signal, sub-threshold equivalent circuit model was derived from the laser rate equations to model the measured laser impedance. Several characteristic carrier lifetimes were obtained directly from these electrical impedance measurements. From the temperature dependence of the QW escape time, it was found that hole rather than electron leakage is dominant in the AlGaInAs system due to the relatively low valence band offset. This may explain why the improvement of T0 in AlGaInAs QW 1.55 mum active regions is limited.

  10. VizieR Online Data Catalog: Dimethyl sulfide laboratory um, mm & FIR spectra (Jabri+, 2016)

    NASA Astrophysics Data System (ADS)

    Jabri, A.; Nguyen, H. V. L.; Mouhib, H.; Tchana, F. K.; Manceron, L.; Stahl, W.; Kleiner, I.

    2016-02-01

    DMS was purchased from Alfa Aesar GmbH & Co KG, Karlsruhe, Germany and used without further purification. The microwave spectrum was measured in the frequency range 2-40GHz using two Molecular Beam Fourier Transform MicroWave (MB-FTMW) spectrometers in Aachen, Germany. The millimeter spectrum was recorded in the 50-110GHz range. The FIR spectrum was measured for the first time at high resolution using the FT spectrometer and the newly built cryogenic cell at the French synchrotron SOLEIL. (3 data files).

  11. High-speed interconnect using 1.3 um laser and fiber array

    NASA Astrophysics Data System (ADS)

    Zhu, Sherman; Uchida, Toshi; Tani, Takuhori

    1997-04-01

    Multifiber optic interconnects are attractive for high- throughput computer systems and asynchronous transfer mode (ATM) switching systems. We have developed a high- performance 10-fiber interconnect with each fiber operating at a high speed of 1 Gb/s. The modules have a receptacle for mechanically transferred push-on (MTP) multifiber push pull connector. The hermetic package is surface mount type and solder reflowable. The transmitter (Tx) is dc-coupled and the receiver (Rx) is ac-coupled with a cutoff of 7 kHz. The electrical interface is differential current mode logic (CML) or emitter coupled logic (ECL), and the optical interface is a 12-fiber connector. Single-mode glass fibers (9.5 micrometer) or multimode glass graded-index fibers (62.5 micrometer) were used. Tx contains a laser-driver IC, while Rx contains pre-amplifier and postamplifier, and comparator circuits. All the ICs are minus 5.2 V bipolar GaAs, and Tx plus RX consumes 4 W. The power in a fiber is about 100 (mu) W. The back-to-back skew is less than 80 ps. For a non-return-to-zero (NRZ) 223-1 pseudo-random bit stream, the error rate was less than 10 -12 with all the channels transmitting different signals simultaneously and a 100-m small-skew (1.2 ps/m) fiber ribbon. The link worked up to an atmosphere temperature of 80 degrees Celsius.

  12. Distribution of benthic foraminifers (>125 um) in the surface sediments of the Arctic Ocean

    USGS Publications Warehouse

    Osterman, Lisa E.; Poore, Richard Z.; Foley, Kevin M.

    1999-01-01

    Census data on benthic foraminifers (>125 ?m) in surface sediment samples from 49 box cores are used to define four depth-controlled biofacies, which will aid in the paleoceanographic reconstruction of the Arctic Ocean. The shelf biofacies contains a mix of shallow-water calcareous and agglutinated species from the continental shelves of the Beaufort and Chukchi Seas and reflects the variable sedimentologic and oceanic conditions of the Arctic shelves. The intermediate-depth calcareous biofacies, found between 500 and 1,100 meters water depth (mwd), contains abundant Cassidulina teretis , presumably indicating the influence of Atlantic-derived water at this depth. In water depths between 1,100 and 3,500 m, a deepwater calcareous biofacies contains abundant Oridorsalis umbonatus . Below 3,500 mwd, the deepwater mixed calcareous/agglutinated biofacies of the Canada, Makarov, and Eurasian Basins reflects a combination of low productivity, dissolution, and sediment transport. Two other benthic foraminiferal species show specific environmental preferences. Fontbotia wuellerstorfi has a depth distribution between 900 and 3,500 mwd, but maximum abundance occurs in the region of the Mendeleyev Ridge. The elevated abundance of F. wuellerstorfi may be related to increased food supply carried by a branch of Atlantic water that crosses the Lomonosov Ridge near the Russian Continental Shelf. Triloculina frigida is recognized to be a species preferring lower slope sediments commonly disturbed by turbidites and bottom currents. INTRODUCTION At present, our understanding of the Arctic Ocean lags behind our understanding of other oceans, and fundamental questions still exist about its role in and response to global climate change. The Arctic Ocean is particularly sensitive to climatic fluctuations because small changes in the amounts of sea-ice cover can alter global albedo and thermohaline circulation (Aagaard and Carmack, 1994). Numerous questions still exist regarding the nature and timing of paleoclimatic events in the Arctic Ocean. In order to attempt to answer some of these questions, baseline studies are imperative. This report discusses the distribution of benthic foraminifers in surface sediment samples from 49 box cores (figs. 1 and 2, table 1) collected by the U.S. Geological Survey (USGS) with the assistance of the U.S. Coast Guard (USCG). A modern data set of benthic foraminiferal distribution is necessary for interpreting the paleoclimatic and oceanographic history of the Arctic Ocean.

  13. Experimental study of biological effect by Nd:YAP laser (1.34um)

    NASA Astrophysics Data System (ADS)

    Zhu, Jing; Zhang, Hui-Guo; Lu, Liping

    2005-07-01

    Objective: To evaluate the biological effect of different power, irradiation time of Nd: YAP laser (1341nm). Method: The canine skin, bronchia, stomach, bladder, uterus were irradiated with different irradiation power and time. The effect was observed by naked eyes, light microscope, and electric microscope. Result: Having positive correlation with power and irradiating time, the biological effect of Nd: YAP laser is mainly thermal coagulation effect with some gasified ablation effect. Under the condition where the diameter of faculae irradiating on canine skin was 3 mm, the thermal coagulation dose reaching deep derma was 5W 4s, 10w 1s;the thermal coagulation dose puncturing the whole layer was 5W, 6s, 10W, 4s; the thermal coagulation dose reaching whole stratum was 10W 5s, 20W 4s, 30W 2s, 40-60W 1s on stomach (Thickness 6mm), was 40W, 2s, 30W, 3s, 20W, 4s, 10W, 6s on bladder (Thickness 6mm ,irradiation underwater), was 10W, 4s on bronchia (Thickness 2 mm) and was 30W 3s, 20W 5s, 10W 6s on uterus (Thickness 6mm). Conclusion: Having positive correlation with power and irradiating time, the biological effect of Nd: YAP laser is mainly thermal coagulation effect with some gasified ablation effect. Under the condition where the diameter of faculae irradiating on canine skin was 3 mm, it is safe when the dose is 5W, and the irradiating time is less than 4s; the dose is 10W, and the irradiating time is less than 1 s. Under these conditions, the gastric area is used to coagulating and ablating. It is safe when the dose is less than 10W 5s, 20W 4s, 30W 2s. Under these condition, The bladder (thickness 6mm) is coagulated and ablated. It is safe when the dose is no more than 40W, 1s, 30W, 2s, 20W, 3s, 10W, 5s.Under the condition where bronchia (thickness 2mm) is coagulated and ablated, it is safe when the dose is less than 10W, 3s.Under the condition where uterus (thickness 6mm) is coagulated and ablated, it is safe when the dose is less than 30W, 2s, 20W, 4s, 10W, 5s.

  14. A Catalog of 1.5273 um Diffuse Interstellar Bands Based on APOGEE Hot Telluric Calibrators

    NASA Astrophysics Data System (ADS)

    Elyajouri, M.; Monreal-Ibero, A.; Remy, Q.; Lallement, R.

    2016-08-01

    High resolution stellar spectroscopic surveys provide massive amounts of diffuse interstellar bands (DIBs) measurements. Data can be used to study the distribution of the DIB carriers and those environmental conditions that favor their formation. In parallel, recent studies have also proved that DIBs extracted from stellar spectra constitute new tools for building the 3D structure of the Galactic interstellar medium (ISM). The amount of details on the structure depends directly on the quantity of available lines of sight. Therefore there is a need to construct databases of high-quality DIB measurements as large as possible. We aim at providing the community with a catalog of high-quality measurements of the 1.5273 μm DIB toward a large fraction of the Apache Point Observatory Galactic Evolution Experiment (APOGEE) hot stars observed to correct for the telluric absorption and not used for ISM studies so far. This catalog would complement the extensive database recently extracted from the APOGEE observations and used for 3D ISM mapping. We devised a method to fit the stellar continuum of the hot calibration stars and extracted the DIB from the normalized spectrum. Severe selection criteria based on the absorption characteristics are applied to the results. In particular limiting constraints on the DIB widths and Doppler shifts are deduced from the H i 21 cm measurements, following a new technique of decomposition of the emission spectra. From ˜16,000 available hot telluric spectra we have extracted ˜6700 DIB measurements and their associated uncertainties. The statistical properties of the extracted absorptions are examined and our selection criteria are shown to provide a robust dataset. The resulting catalog contains the DIB total equivalent widths, central wavelengths and widths. We briefly illustrate its potential use for the stellar and interstellar communities.

  15. 250 um inner diameter hollow waveguide for Er:YAG laser radiation

    NASA Astrophysics Data System (ADS)

    Němec, Michal; Jelínková, Helena; Miyagi, Mitsunobu; Iwai, Katsumasa; Matsuura, Yuji

    2009-02-01

    Advanced application of Er:YAG laser radiation in medical treatment requires a suitable, very precise delivery of this light to a target. In some cases (urology, cardiology, or endodontic treatments), thin waveguides are needed. Therefore a preliminary investigation was conducted with 250/360 μm inner/outer diameter hollow glass waveguides. The waveguide has inner coating made from cyclic olefin polymer and silver layers. All delivery systems were simple and consisted of lens, protector, and the waveguide. The laser source was the Er:YAG system working in a free-running regime and generating radiation at 2.94 μm wavelength. For testing, output laser energy up to 100 mJ with a repetition rate of 1 Hz was chosen. The output laser spatial profile was approximately TEM00 mode, so the structure changes behind the delivery system were readily detected. The energy delivery characteristics were also checked, and the transmission reached 77%. The maximum input fluence into the waveguide was 200 mJ/cm2, and no significant damages to waveguides were observed after the measurements.

  16. Zum Auf und Ab des Meeresspiegels in Skandinavien: Langer Streit um Eustasie oder Isostasie

    NASA Astrophysics Data System (ADS)

    Seibold, Eugen; Seibold, Ilse

    2012-03-01

    The phenomenon of the rise of the Scandinavian shield during the Holocene and the concomitant fall in level of the Baltic Sea has been investigated for centuries. Already in medieval times, there were reports about the coastlines of the Gulf of Bothnia that are full of relevant observations. During the eighteenth century, scientists such as Celsius and Linnaeus collected observations such as these. The result was that the search for the possible explanations of this rise-and-fall phenomenon intensified. The generally favoured explanation was that there was an active sinking of sea level in the Baltic rather than an active rising of the land surface in Fennoscandia. This was because water was seen as mobile, in contrast to a „terra firma". The relevant discussion was often emotional, and here, we try to illustrate it using material from the Geologenarchiv Freiburg (von Hoff, von Buch and Goethe). No more than a few decades later, it became obvious by the theory of Ice Age that both the sea level and the land could be mobile (eustatic sea level changes—glacial isostasy). Additionally, of course, plate tectonics had some influence: Norway is situated at the western end of the Eurasian plate and is part of a passive continental margin. There are still open research problems, many of which can be addressed using modern methods of satellite-based geophysics and geodesy. Some other aspects as the permanent uplift trend of Scandinavia since the Cambrium or the rhythmic to and fro of magma in the upper mantle during the Pleistocene are mentioned.

  17. Application of 2-um wavelength holmium lasers for treatment of skin diseases

    NASA Astrophysics Data System (ADS)

    Shcherbakov, Ivan A.; Klimov, Igor V.; Tsvetkov, Vladimir B.; Nerobeev, Alexander I.; Sadovnikova, Lija B.; Eliseenko, Vladimir I.

    1994-09-01

    Theoretical and experimental analysis of the efficiency of application of 2 micrometers pulsed holmium laser for cosmetic and plastic surgery and dermatology is carried out. Preliminary experiments were carried out on rats. Solid state 2 micrometers pulsed laser was allowed to operate in free running mode with pulse energy up to 1.5 J and pulse repetition rate up to 5 Hz. To deliver emission to the object a flexible quartz fiber without further focusing of 2.5 m in length and 400 micrometers of the core diameter was used. The effect of the different power density emission on the skin was studied. The second stage was the study of the influence of 2 micrometers emission on human skin. The results of the removal of hemangioma, papilloma, telangiectasia, nevus, nevus acantholytic, xanthelasma palpebral, verruca, chloasma, pigmental spots, tattoos, etc. are presented. Precision, simplicity, efficiency, and the high cosmetic effect of these operations is noted.

  18. [The life story of Joaquim Alberto Cardoso de Melo: Quincas, Um berro à vida].

    PubMed

    Zancan, Lenira; Matida, Álvaro Hideyoshi

    2015-10-01

    The article seeks to reflect on the contribution of Joaquim Alberto Cardoso de Melo (1936-1993) to the field of public health relating his life story and his scientific production with core issues of education and health, present in his time and which remain in debate to this day. His contribution resulted in the production of new meanings for health practices, with the understanding as social and transdisciplinary phenomena. Based on conversations with co-authors and friends and rereading of his texts, it was decided to approach his biography from: (i) his skills and participation in initiatives and practices of preventive medicine and popular education, which fomented the critical analysis of health education; (ii) his presence as an educator in public health courses throughout the country, eliciting the deconstruction of the theories and practices of education and health with managers, students, professionals and teachers; (iii) his availability for transdisciplinary dialogue with the humanities and social sciences in the search for "epistemological sutures" between reason and passion, capable of responding to the dilemmas and challenges of healthcare work. These three trajectories indicate that the performance of "Quincas" must be understood from his restlessness as a health professional and educator, engaged in the production of knowledge and practices related to the complexity of the phenomenon of life. PMID:26465867

  19. Comparative study of i-line and DUV lithography for 0.35 um and beyond

    NASA Astrophysics Data System (ADS)

    Samarakone, Nandasiri; Chang, Wayne H.; Tandberg, Erik; Elliot, Christina; Wang, Timothy Y.

    1995-05-01

    New I-line resists are claimed to be usable at 0.35 micrometers design rules. We have examined the suitability of several such materials (JSR IX750, Sumitomo PFi-38a, OCG RX64I) for this purpose and compared them with our production 0.5 micrometers resist, JSR IX700. A variety of criteria have been used, including the measured focus exposure windows at e-min and e-max, DOF vs. CD for grouped and isolated lines as well as contacts, linearity, and proximity response as a function of pitch. A limited study has been done on the impact of embedded phase shift reticles on printing small geometry contacts. We report upon the process improvements observed with two different reticle transmissions, their impact on isofocal bias, as well as the issue of sidelobe formation. Proponents of DUV claim that modern DUV materials exhibit significant advantages in terms of process window and more over are applicable to smaller geometries without the need for supplementary techniques such as phase shifting or modified illumination. In this study, we have examined the performance of a number of DUV materials (BASF ST3.5, OCG ARCH, JSR KRFL2 and an as yet experimental JSR resists) on ASM-L and Nikon excimer laser steppers. Limited results were also obtained using Shipley 2408 and dyed XP-9444 (0.8) on the SVG Micrascan II. Our studies conclude with a comparison of the CD swing observed over a variety of chemically mechanically planarized steps. This has been done for selected I-line and DUV resists with the aid of a TAR or BARC or as in the case of the broad band SVG system either a BARC or a dyed resist.

  20. The impact of atmospheric waves on the O2 1.27-um nightglow distribution

    NASA Astrophysics Data System (ADS)

    Hoshino, Naoya; Fujiwara, Hitoshi; Takagi, Masahiro; Kasaba, Yasumasa; Takahashi, Yukihiro

    O2 -1.27µm nightglow is the indicator of the general circulation at about 95 km in Venus. Recent nightglow observations reported that the nightglow emission showed the temporal variations with a timescale of a few hours and days [e.g.,Gerard et al., 2008]. The temporal variations are thought to be caused by wind fluctuations due to atmospheric waves propagating from the lower atmosphere. In recent years, the importance of planetary-scale waves on the general circulation of the Venusian atmosphere has been recognized. Forbes and Konopliv [2007] suggested the propagation of planetary-scale waves originated in the cloud deck into the upper atmosphere. However, the impact of the planetary-scale waves on the Venusian upper atmosphere has not been investigated yet. In this study, we have performed numerical simulations with a general circulation model (GCM), which includes the altitude region of 80 -about 200 km in order to understand the impact of atmospheric waves on the nightglow distribution. Our model considers the chemical processes and calculates the O2 -1.27µm nightglow intensity. The planetary-scale waves (thermal tides, Kelvin wave, and Rosbby wave) are imposed at the lower boundary. The amplitudes and phase velocities of the waves are assumed from the study by Del Genio and Rossow [1990]. The simulation results show dominance of the Kelvin wave at about 80 -120 km with a vertical wavelength of about 40 -50 km. The amplitude of the zonal wind fluctuation caused by the Kelvin wave has a maximum value of about 9 m/s at about 95 km. Our results suggest that the Kelvin wave would cause the wind variation of the nightglow emission region between the 00:00LT -00:40LT with a period of 4 days. In this presentation, we will show the details of our simulation results considering the planetary-scale waves. In addition, we will present the initial results of a simulation considering the small-scale gravity wave.

  1. Alice's adventures in um-derland: Psycholinguistic sources of variation in disfluency production

    PubMed Central

    Fraundorf, Scott H.; Watson, Duane G.

    2013-01-01

    This study tests the hypothesis that three common types of disfluency (fillers, silent pauses, and repeated words) reflect variance in what strategies are available to the production system for responding to difficulty in language production. Participants' speech in a storytelling paradigm was coded for the three disfluency types. Repeats occurred most often when difficult material was already being produced and could be repeated, but fillers and silent pauses occurred most when difficult material was still being planned. Fillers were associated only with conceptual difficulties, consistent with the proposal that they reflect a communicative signal whereas silent pauses and repeats were also related to lexical and phonological difficulties. These differences are discussed in terms of different strategies available to the language production system. PMID:25339788

  2. Teaching Advanced Concepts in Computer Networks: VNUML-UM Virtualization Tool

    ERIC Educational Resources Information Center

    Ruiz-Martinez, A.; Pereniguez-Garcia, F.; Marin-Lopez, R.; Ruiz-Martinez, P. M.; Skarmeta-Gomez, A. F.

    2013-01-01

    In the teaching of computer networks the main problem that arises is the high price and limited number of network devices the students can work with in the laboratories. Nowadays, with virtualization we can overcome this limitation. In this paper, we present a methodology that allows students to learn advanced computer network concepts through…

  3. Isolation of UmRrm75, a gene involved in dimorphism and virulence of Ustilago maydis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Ustilago maydis displays dimorphic growth, alternating between a saprophytic haploid yeast form and a filamentous dikaryon, generated by mating of haploid cells and which is an obligate parasite. Induction of the dimorphic transition of haploid strains in vitro by change in ambient pH has been used...

  4. Are "physiological" and "psychological" addiction really different? well, no! ... um, er, yes?

    PubMed

    Newlin, David B

    2008-01-01

    The distinction often made between psychological and physiological addiction is a form of mind-body dualism. Therefore, it is a false distinction. However, this does not imply that behavioral and autonomic symptoms of addiction have the same brain substrates. In fact, they likely do not, although there is some overlap. PMID:18570028

  5. High-quantum-efficiency 2.2-um InGaAs MOCVD photodiodes

    NASA Astrophysics Data System (ADS)

    Wojtczuk, Steven; Colter, Peter C.; Jhabvala, Murzy D.

    1997-04-01

    Photodiodes responding in the 0.8-2.3 micrometers wavelength range are of interest in a wide range of applications, from wind- shear detection systems which use eyesafe 2.1 micrometers lasers to differential absorption LIDAR aerosol measurements of CO2. In this paper, we report on uncooled, broadband, 2.25 micrometers lattice-mismatched 0.55eV In0.72Ga0.28As photodiode arrays, in which the cutoff wavelength has been 'extended' from the 1.65 micrometers which is standard for 0.74eV In0.53Ga0.47As lattice-matched to InP wafers. InxGa1-xAs step-grading layers were used to transition from the InP wafer to the final In0.72Ga0.28As photodiode material during the metal organic chemical vapor deposition epitaxial growth. Linear 64 X 1 photodiode arrays were made with an independently-verified external quantum efficiency above 50 percent from 0.8 to 2.2 micrometers using MgF2/ZnS dual layer antireflection coating. Average 300 degree K area-normalized dark current for these N/P diodes was 5 X 10-5 A/cm2 at 10mV reverse bias.

  6. On Ensino de Astronomia: Desafios para Implantação

    NASA Astrophysics Data System (ADS)

    Faria, R. Z.; Voelzke, M. R.

    2008-09-01

    Em 2002 o ensino de Astronomia foi proposto como um dos temas estruturadores pelos Parâmetros Curriculares Nacionais e sugerido como facilitador para que o aluno compreendesse a Física como construção humana e parte do seu mundo vivencial, mas raramente seus conceitos foram ensinados. A presente pesquisa discute dois aspectos relacionados à abordagem de Astronomia. O primeiro aspecto é se ela está sendo abordada pelos professores do Ensino Médio e o segundo, aborda a maneira como ela está sendo ensinada. Optou-se pela aplicação de um questionário a partir do 2° semestre de 2006 e durante o ano de 2007 com professores que ministram a disciplina de Física, os quais trabalham em escolas estaduais em Rio Grande da Serra, Ribeirão Pires e Mauá no estado São Paulo. Dos 66,2% dos professores que responderam ao questionário nos municípios de Rio Grande da Serra, Ribeirão Pires e Mauá, 57,4% não aplicaram nenhum tópico de astronomia, 70,2% não utilizaram laboratório, 89,4% não utilizaram qualquer tipo de programa computacional, 83,0% nunca fizeram visitas com alunos a museus e planetários e 38,3% não indicaram qualquer tipo de livro ou revista referente à astronomia aos seus alunos. Mesmo considerando a Astronomia um conteúdo potencialmente significativo, esta não fez parte dos planejamentos escolares. Portanto são necessárias propostas que visem estratégias para a educação continuada dos professores como, por exemplo, cursos específicos sobre o ensino em Astronomia.

  7. Aquisição de Estreptococos Mutans e Desenvolvimento de Cárie Dental em Primogênitos

    PubMed Central

    NOCE, Erica; RUBIRA, Cassia Maria Fischer; da Silva ROSA, Odila Pereira; da SILVA, Salete Moura Bonifácio; BRETZ, Walter Antonio

    2011-01-01

    Objetivo Avaliar o momento de aquisição de estreptococos mutans (EM), desenvolvimento de cárie dental e as variáveis a eles associadas no decorrer de 23 meses, em primogênitos de famílias de baixo nível socioeconômico, desde os sete meses de idade. Método A amostra foi selecionada com base em mães densamente colonizadas por EM, incluindo todos os membros de 14 famílias que conviviam na mesma casa. Foram envolvidos no estudo 14 mães, pais e primogênitos e 8 parentes, na maioria avós. Exames clínicos e radiográficos iniciais determinaram os índices de cárie e condição periodontal dos adultos. Contagens de EM foram feitas em todos os adultos nas duas primeiras visitas. Nas crianças foram avaliados os níveis de EM, o número de dentes e de cáries, em quatro visitas. Resultados A prevalência de EM nos adultos foi alta, estando ausente em apenas um dos pais. EM foram detectados em 1, 2, 3 e 10 crianças, respectivamente nas visitas #1, 2, 3 e 4. A cárie dental foi detectada em apenas três crianças na última visita (aos 30 meses de idade), as quais apresentaram escores de EM significantemente maiores que as crianças sem cárie, na mesma visita. Conclusão Exclusivamente a condição social de baixa renda e mães densamente colonizadas por EM não são sinônimo de colonização precoce e alta atividade de cárie em crianças cuidadas em casa. O desenvolvimento de cárie está significantemente associado a escores elevados de EM nas crianças. PMID:22022218

  8. Lo que da buen resultado en casa. Resultados de la investigacion y Actividades de aprendizaje: Sentido comun y diversion para ninos y adultos (What Works at Home. Research Findings and Learning Activities: Common Sense and Fun for Adults and Children).

    ERIC Educational Resources Information Center

    Crook, Shirley, Ed.

    As part of an effort to encourage Hispanic parents to help their children in school, this home learning guide, which can also be obtained in taped versions, provides parents with learning activities with which to engage their children. Based on research findings, the activities are divided into the following categories: curriculum of the home,…

  9. Instructional Technology and the Adult Learner. Theory, Innovation, and Practice in Andragogy. No. 2. = La Technologia Educativa y el Aprendiz Adulto. Teoria, Innovacion y Practica en Andragogia. No. 2.

    ERIC Educational Resources Information Center

    Wager, Walter

    This second issue of a series on theory, innovation, and practice in andragogy analyzes some of the instructional variables in adult learning and discusses ways to influence the degree of learning through the application of instructional and behavioral technologies. It unites theory and practice, generating recommendations from the abstract…

  10. Directory of Adult Education Periodicals. Seventh Revised Edition. = Repertoire des Periodiques sur l'Education des Adultes. Septieme Edition Revisee. = Repertorio de Periodicos sobre Educacion de Adultos. Septima Edicion Revisada.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). Div. of Primary Educ., Literacy & Adult Educ., Educ. in Rural Areas

    Intended as a reference for persons seeking documentation on adult education, this directory provides a list of professional journals and newsletters--international, national, and regional--appearing regularly and dealing either exclusively or substantially with information and activities relating to adult education. This seventh revised edition…

  11. Directory of Adult Education Periodicals. Sixth Revised Edition = Repertoire des Periodiques sur l'Education des Adultes. Sixieme Edition Revisee = Repertorio de Periodicos sobre Educacion de Adultos. Sexta Edicion Revisada.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). Div. of Literacy, Adult Education and Rural Development.

    This directory lists approximately 175 adult education periodicals published in Africa, Arab states, Asia and the Pacific, Europe, North America, Latin America and the Caribbean, and other international areas. Within each category, periodicals are further divided into the individual countries in which they are published. Each entry may provide…

  12. Adult EFL Reading Selection: Influence on Literacy (Procesos de selección de lecturas en estudiantes adultos de inglés como lengua extranjera y su influencia en la habilidad lectora)

    ERIC Educational Resources Information Center

    Basallo Gómez, Juan Sebastián

    2016-01-01

    This paper is about the impact of systematic reading selection used to promote English as foreign language learning in adult students. A qualitative action research methodology was used to carry out this project. Ten class sessions were designed to provide students an opportunity to select texts according to criteria based upon their language…

  13. Nuestras cuentas diarias: Matematicas. Primaria para adultos, Primera parte, Volumens 1 y 2. Edicion Experimental (Our Daily Accounting: Mathematics. Primer for Adults, Part One, Volumes 1 and 2. Experimental Edition).

    ERIC Educational Resources Information Center

    Instituto Nacional para la Educacion de los Adultos, Mexico City (Mexico).

    These workbooks are part of a Mexican series of instructional materials designed for Spanish speaking adults who are in the process of becoming literate or have recently become literate in their native language. The workbooks, divided in two volumes, are designed to teach skills required in managing ordinary financial transactions and daily tasks…

  14. Nuestras cuentas diarias: Matematicas. Primaria para adultos, Segunda parte, Volumens 1 y 2. Edicion Experimental (Our Daily Accounting: Mathematics. Primer for Adults, Part Two, Volumes 1 and 2. Experimental Edition).

    ERIC Educational Resources Information Center

    Instituto Nacional para la Educacion de los Adultos, Mexico City (Mexico).

    These workbooks are part of a Mexican series of instructional materials designed for Spanish speaking adults who are in the process of becoming literate or have recently become literate in their native language. The workbooks are designed to teach skills needed to manage ordinary financial transactions and daily tasks requiring a knowledge of…

  15. La Palabra es Nuestra: Primaria para Adultos. Segunda Parte, Volumen 1-2. Edicion Experimental (The Language Is Ours: Primer for Adults. Part Two, Volumes 1-2. Experimental Edition).

    ERIC Educational Resources Information Center

    Instituto Nacional para la Educacion de los Adultos, Mexico City (Mexico).

    These workbooks are part of a Mexican series of instructional materials designed for Spanish speaking adults who are in the process becoming literate or have recently become literate in their native language. They provide readings and exercises for developing literacy skills. Pictures and fill-in-the blank exercises appear frequently. Volume 1…

  16. Modelo Pedagogico de Educacion Primaria para Adultos: Manual para el Asesor de Estudiantes Libres. Primera Parte (A Pedagogical Model for Adult Primary Education: Manual for the Student Advisor. Part One).

    ERIC Educational Resources Information Center

    Instituto Nacional para la Educacion de los Adultos, Mexico City (Mexico).

    This guide, part of a Mexican series of instructional materials, is intended for advisors of students participating in an adult education program offered through public and private organizations in communities in Mexico. The first part of the program comprises Spanish and math; the second, education for family life, education for community life,…

  17. La Palabra es Nuestra: Primaria para Adultos. Primera Parte, Volumen 1-2. Edicion Experimental. (The Language Is Ours: Primer for Adults. Part One, Volumes 1-2. Experimental Edition).

    ERIC Educational Resources Information Center

    Instituto Nacional para la Educacion de los Adultos, Mexico City (Mexico).

    These workbooks are part of a Mexican series of instructional materials designed for Spanish speaking adults who are in the process of becoming literate or have recently become literate in their native language. These workbooks, designed to continue developing literacy skills, include pictures, dialogues, crossword puzzles, and fill-in-the blank…

  18. Analysis of astronomy knowledge of the students in the Federal Institute Sao Paulo

    NASA Astrophysics Data System (ADS)

    Moraes, A. C.; Voelzke, M. R.

    2014-08-01

    Este trabalho é parte integrante da pesquisa de mestrado acadêmico em ensino de ciências. Nele, busca-se apresentar os resultados da pesquisa realizada entre os 106 alunos do curso superior de tecnologia em automação industrial do Instituto Federal de Educação, Ciência e Tecnologia de São Paulo campus Cubatão, divididos em cinco turmas, duas no período matutino e três no período noturno. A análise dos resultados deste pré questionárioconstatou a falta de conhecimento básico dos discentes, sobre assuntos relacionados à astronomia, o que pode ser atribuído ao ineficiente processo de aprendizado pelo qual eles passaram tanto no ensino médio como no ensino fundamental, em escolas municipais, estaduais e particulares onde estudaram. No ensino de astronomia, têm-se diagnosticado constantemente diversas dificuldades conceituais tanto por parte de alunos como de professores de todas as áreas e níveis de ensino e poucos de fato a compreendem (ALBRECHT; VOELZKE, 2010). Demonstra-se as duas etapas concluídas do trabalho. A primeira etapa indica a análise dos conhecimentos prévios sobre conceitos astronômicos, através do questionário com 25 perguntas. A fim de corrigir as falhas constatadas, experimentalmente ministrou-se, externo ao conteúdo programático, um curso básico em astronomia, com diferentes estratégias de ensino, tais como, utilização de aulas expositivas dialogadas, recursos audiovisuais e palestras, para corrigir as dificuldades diagnosticadas. Essas estratégias de ensino se comprovaram adequadas às necessidades dos alunos e os conceitos foram finalmente compreendidos. Ao término do curso, completado o interstício de 120 dias, para caracterizar que houve a aprendizagem significativa, realizou-se uma nova pesquisa, quando, exatamente os mesmos 106 alunos responderam as mesmas 25 questões aplicadas na primeira etapa. Constata-se na segunda etapa, após análise, que em todas as questões, houve maior compreensão dos assuntos

  19. Ensino de astronomia e óptica: é possível fazê-lo de forma contextualizada no nível médio?

    NASA Astrophysics Data System (ADS)

    Sobrinho, A. A.; Jafelice, L. C.

    2003-08-01

    Discutimos nossa participação em um curso de treinamento para professores de diversas disciplinas do ensino médio. Nossa preocupação básica foi desenvolver instrumentos educacionais adequados para levar à sala de aula, nesse nível de ensino, de forma contextualizada, questionamentos freqüentes dos alunos sobre astronomia e sua relação com tecnologia e sociedade. Encaminhamos questões como: a evolução da astronomia, suas relações com outros ramos do conhecimento humano e conseqüentes aplicações; avanços na tecnologia dos instrumentos ópticos versus a importância da observação do céu a olho nu; a relação entre olho humano, luneta e telescópio; e desenvolvimento da tecnologia espacial e sua influência em nosso cotidiano. Objetivamos com isto fazer um resgate histórico e pedagógico das aplicações e observações do céu no cenário escolar, destacando a relação entre eventos astronômicos, olho humano, instrumentos mediadores e suas contextualizações históricas e sociais. Produtos desta abordagem foram o desenvolvimento e a adaptação de práticas e materiais instrucionais diversos (e.g., "espelhos" de isopor e "raios luminosos" de bolinhas de gude; montagens envolvendo velas, lasers, lentes e espelhos; desmonte e análise de peças de um telescópio; etc.). Além disto, como outro resultado deste trabalho, elaboramos textos sobre história da astronomia e da óptica para atividades em classe. Com estas ações visamos facilitar a concretização de conceitos físicos envolvidos, exemplificar um ensino contextualizado e interdisciplinar motivado por temas astronômicos e favorecer que práticas e discussões feitas com os treinandos possam ser transpostas para a sala de aula. A reação dos professores às práticas propostas foi bastante positiva. Todos esses aspectos são discutidos em detalhe neste trabalho. (PPGECNM/UFRN; PRONEX/FINEP; NUPA/USP; Temáticos/FAPESP)

  20. Cosmoeducação: uma proposta para o ensino de astronomia

    NASA Astrophysics Data System (ADS)

    Medeiros, L. A. L.; Jafelice, L. C.

    2003-08-01

    Entende-se por cosmoeducação o desenvolvimento vivencial da unidade homem-cosmo. Este conceito é norteado pela psicologia transpessoal, que estuda o ser humano em sua totalidade, onde suas relações ecológicas e cósmicas são de grande importância. Constata-se uma necessidade latente no ser humano moderno em resgatar uma relação holística com o Universo. Neste trabalho exploramos meios de cultivar a consciência de que o ser humano constitui parte integrante do cosmo e se relaciona com este com o objetivo de promover em si uma percepção ambiental mais ampla. Nossa hipótese de trabalho inicial foi que o ensino de conteúdos básicos em astronomia realizado através de uma abordagem holística, que incorpore práticas vivenciais correlacionadas àqueles conteúdos, pode despertar no indivíduo sua identidade cósmica. O método que utilizamos é o fenomenológico e o universo desta pesquisa é um grupo de estudantes da disciplina de Astronomia (Curso de Licenciatura em Geografia/UFRN), onde realizamos observação participante, entrevistas, depoimentos e as práticas vivenciais mencionadas. Neste caso estamos desenvolvendo e adaptando exercícios de algumas técnicas terapêuticas de psicologia transpessoal, que um de nós (LALM) tem aplicado no contexto clínico, para trabalhar aspectos cognitivos envolvidos naquele processo de conscientização cósmica. Resultados parciais claramente referendam a hipótese inicial. Um resultado a destacar é fruto de uma dinâmica de representação corporal interiorizada do eclipse lunar, envolvendo um pequeno grupo daqueles estudantes, na qual conteúdos míticos afloraram de maneira espontânea e contundente para todos, sugerindo ressonância, ou pelo menos isomorfismo, entre o macro e o microcosmo. Este e outros resultados são discutidos em detalhe neste trabalho. (PPGECNM/UFRN; PRONEX/FINEP; NUPA/USP; Temáticos/FAPESP).

  1. A Concepção de Universo entre Alunos do Ensino Médio de São Paulo e suas Fontes de Aquisição

    NASA Astrophysics Data System (ADS)

    Araújo, M. A. A.; Elias, D. C. N.; Amaral, L. H.; Araújo, M. S. T.; Voelzke, M. R.

    2006-08-01

    Nesse trabalho procurou-se identificar por meio de um questionário as concepções de Universo, de espaço e tempo que sustentam a visão de mundo de um grupo de 270 estudantes de Ensino Médio, pertencentes a três escolas de São Paulo. As questões relacionadas aos conhecimentos prévios dos estudantes permitiram constatar que há pouco conhecimento acerca dos temas investigados, destacando-se que apenas 20% dos alunos foram capazes de relacionar as semanas com as fases da lua, enquanto 28% associaram as estações do ano à inclinação do eixo de rotação da Terra e 23% tinham noções das distâncias entre objetos celestes próximos da Terra. Enquanto 56% conseguiram relacionar o Big Bang com a origem do Universo, verificou-se que 37% reconheciam ano-luz como unidade de distância e 60% concebiam o Sol como uma estrela. No que se refere às fontes de aquisição que proporcionaram esses conhecimentos, apesar de 60% dos alunos indicarem a escola como principal fonte dos conhecimentos de Ast! ronomia, verificou-se claramente que para a maioria dos alunos seus conceitos ainda são inadequados, havendo necessidade de aprimoramento da abordagem desses conteúdos, pois apesar de popular, a Astronomia ainda é veiculada de maneira pouco esclarecedora e com imprecisões. Nesse contexto, são discutidas algumas possíveis contribuições que podem ser dadas para o ensino de Astronomia pelo uso das ferramentas computacionais nas escolas.

  2. Laser activity at 1.18 um, 1.07 um, and 0.97 umin the low phonon energy crystalline hosts KPb2Br5 and RbPb2Br5 doped with Nd3+

    SciTech Connect

    Rademaker, K; Heumann, E; Payne, S A; Huber, G; Krupke, W F; Isaenko, L I; Burger, A

    2004-09-15

    For the first time laser activity has been achieved in the low phonon energy, moisture-resistant bromide host crystals, neodymium-doped potassium lead bromide (Nd{sup 3+}:KPb{sub 2}Br{sub 5}) and rubidium lead bromide (Nd{sup 3+}:RbPb{sub 2}Br{sub 5}). Laser activity at 1.07 {micro}m was observed for both crystalline materials. Laser operation at the new wavelengths 1.18 {micro}m and 0.97 {micro}m resulting from the {sup 4}F{sub 5/2} + {sup 2}H{sub 9/2} {yields} {sup 4}I{sub J} transitions (J=13/2 and 11/2) in Nd:RPB was achieved for the first time in a solid state laser material. Rare earth- doped MPb{sub 2}Br{sub 5} (M=K, Rb) is a promising candidate for long wavelength infrared applications because of its low phonon frequencies and other favorable features. In principle, Nd{sup 3+}:MPb{sub 2}Br{sub 5} has high potential for laser operation at new wavelengths as well as for the realization of short-wavelength lasing due to upconversion processes.

  3. IIP Tropospheric Infrared Mapping Spectrometers (TIMS) demonstration of CO retrieval, including multi-layer, from atmospheric data acquired simultaneously in the solar reflective region near 2.3 um and the thermal emissive region near 4.7 um

    NASA Astrophysics Data System (ADS)

    Mergenthaler, J. L.; Kumer, J.; Roche, A. E.; Rairden, R. L.; Blatherwick, R.; Hawat, T.; Desouza-Machado, S.; Hannon, S.; Chatfield, R. B.

    2008-12-01

    The NASA Earth Science Technology Office (ESTO) Instrument Incubator Program (IIP) Tropospheric Infrared Mapping Spectrometers (TIMS) have been developed to demonstrate measurement capability, when deployed in space, for multi-layer retrieval of CO from spectral measurements acquired in the solar reflective (SR) region ~ 4281 to 4301 cm-1 and in the thermal InfraRed (TIR) region ~ 2110 to 2165 cm-1. We describe joint deployment at Denver University (DU) with co-investigators there of the TIMS, and of the DU colleagues FTS, to acquire simultaneous measurements of atmospheric spectra in the SR and the TIR. The FTS provided validation radiance data for the TIMS. The TIMS retrievals of CO, H2O and CH4 agreed well with validation vs these as retrieved from the DU data, AIRS retrieval, standard models and ECMWF. The TIMS CO retrievals included column retrieved from the just the SR data, column retrieved from just the TIR data, and a simple two-layer retrieval from the combined data sets. The data were acquired in an operational mode that mimicked the operations in a conceptual application that would provide footprints, coverage, refresh time as in the Decadal Survey GEO-CAPE mission statement. Very encouraging CO precisions were achieved, e.g., the TIMS CO column retrieval from the SR data demonstrated better than the 10% precision requirement as listed on slide 32 of the GEO-CAPE Reference document http://geo- cape.larc.nasa.gov/docs/GEOMAC_FinalReport_no_costs.ppt

  4. Spectrally Consistent Scattering, Absorption, and Polarization Properties of Atmospheric Ice Crystals at Wavelengths from 0.2 to 100 um

    NASA Technical Reports Server (NTRS)

    Yang, Ping; Bi, Lei; Baum, Bryan A.; Liou, Kuo-Nan; Kattawar, George W.; Mishchenko, Michael I.; Cole, Benjamin

    2013-01-01

    A data library is developed containing the scattering, absorption, and polarization properties of ice particles in the spectral range from 0.2 to 100 microns. The properties are computed based on a combination of the Amsterdam discrete dipole approximation (ADDA), the T-matrix method, and the improved geometric optics method (IGOM). The electromagnetic edge effect is incorporated into the extinction and absorption efficiencies computed from the IGOM. A full set of single-scattering properties is provided by considering three-dimensional random orientations for 11 ice crystal habits: droxtals, prolate spheroids, oblate spheroids, solid and hollow columns, compact aggregates composed of eight solid columns, hexagonal plates, small spatial aggregates composed of 5 plates, large spatial aggregates composed of 10 plates, and solid and hollow bullet rosettes. The maximum dimension of each habit ranges from 2 to 10,000 microns in 189 discrete sizes. For each ice crystal habit, three surface roughness conditions (i.e., smooth, moderately roughened, and severely roughened) are considered to account for the surface texture of large particles in the IGOM applicable domain. The data library contains the extinction efficiency, single-scattering albedo, asymmetry parameter, six independent nonzero elements of the phase matrix (P11, P12, P22, P33, P43, and P44), particle projected area, and particle volume to provide the basic single-scattering properties for remote sensing applications and radiative transfer simulations involving ice clouds. Furthermore, a comparison of satellite observations and theoretical simulations for the polarization characteristics of ice clouds demonstrates that ice cloud optical models assuming severely roughened ice crystals significantly outperform their counterparts assuming smooth ice crystals.

  5. VizieR Online Data Catalog: 24um fluxes of GOODS-S AGN (Garcia-Gonzalez+, 2015)

    NASA Astrophysics Data System (ADS)

    Garcia-Gonzalez, J.; Alonso-Herrero, A.; Perez-Gonzalez, P. G.; Hernan-Caballero, A.; Sarajedini, V. L.; Villar, V.

    2015-06-01

    We compiled all the data taken around the GOODS South field with the MIPS instrument at 24μm by querying the Spitzer Heritage Archive.1 This field was observed by Spitzer during several campaigns from 2004 January to 2007 March. We focused our study on a region around RA=03:32:36 (J2000) and DE=-27:48:39 (J2000). These data correspond to different observing proposals from different PI, including the Guaranteed Time Observations programme (GTO, PI: G. Rieke) and the GOODS programme (PI: M. Dickinson). We have obtained 151 AORs (Astronomical Observation Request) but only downloaded 127 because the others were from the SWIRE (Spitzer Wide-area InfraRed Extragalactic) survey and were not sufficiently deep. (2 data files).

  6. DETERMINATION OF THE STRONG ACIDITY OF ATMOSPHERIC FINE PARTICLES (<2.5 UM) USING ANNULAR DENUDER TECHNOLOGY

    EPA Science Inventory

    This report is a standardized methodology description for the determination of strong acidity of fine particles (less than 2.5 microns) in ambient air using annular denuder technology. his methodology description includes two parts: art A - Standard Method and Part B - Enhanced M...

  7. IN Like Flint: How the Innovation Incubator at UM-Flint Fosters Social Entrepreneurship in a City Remaking Itself

    ERIC Educational Resources Information Center

    Custer, Nic

    2015-01-01

    This paper focuses on how the University of Michigan-Flint's Innovation Incubator supports emerging for-profit businesses and nonprofit organizations through programming, business plan development, and ongoing mentorship. The Incubator is especially interested in supporting start-ups that address key social issues in the surrounding community,…

  8. The relationship between English language learning strategies and gender among pre-university students: An overview of UMS

    NASA Astrophysics Data System (ADS)

    Kiram, Johannah Jamalul; Sulaiman, Jumat; Swanto, Suyansah; Din, Wardatul Akmam

    2014-06-01

    This study aims to analyze the effects psychological gender differences on the relationship between language learning strategies and their proficiency in English language for pre-university students. Previous researchers found that the more employment of language learning strategies, the more successful the learners are and those with higher level of strategy use are female rather than male. In this study, fifty-six pre-university students (22 males, 34 females) of University Malaysia Sabah participated in this study. Oxford's Strategy Inventory for Language Learning (SILL) self-report questionnaire was adopted to identify the students' language learning strategies, whereas their proficiencies were based on their Malaysian University English Test (MUET) results. Pearson's correlation coefficient, one-way analysis of variance (ANOVA) and the t-test were utilized to make statistical interpretation about the relationship. The knowledge obtained from this study will be helpful for future studies on how to improve the quality of learning and proficiency in English.

  9. VizieR Online Data Catalog: Galaxy structural parameters from 3.6um images (Kim+, 2014)

    NASA Astrophysics Data System (ADS)

    Kim, T.; Gadotti, D. A.; Sheth, K.; Athanassoula, E.; Bosma, A.; Lee, M. G.; Madore, B. F.; Elmegreen, B.; Knapen, J. H.; Zaritsky, D.; Ho, L. C.; Comeron, S.; Holwerda, B.; Hinz, J. L.; Munoz-Mateos, J.-C.; Cisternas, M.; Erroz-Ferrer, S.; Buta, R.; Laurikainen, E.; Salo, H.; Laine, J.; Menendez-Delmestre, K.; Regan, M. W.; de Swardt, B.; Gil de, Paz A.; Seibert, M.; Mizusawa, T.

    2016-03-01

    We select our samples from the Spitzer Survey of Stellar Structure in Galaxies (S4G; Sheth et al. 2010, cat. J/PASP/122/1397). We chose galaxies that had already been processed by the first three S4G pipelines (Pipelines 1, 2, and 3; Sheth et al. 2010, cat. J/PASP/122/1397) at the moment of this study (2011 November). In brief, Pipeline processes images and provides science-ready images. Pipeline 2 prepares mask images (to exclude foreground and background objects) for further analysis, and Pipeline 3 derives surface brightness profiles and total magnitudes using IRAF ellipse fits. We excluded highly inclined (b/a<0.5), significantly disturbed, very faint, or irregular galaxies. Galaxies were also discarded if their images are unsuitable for decomposition due to contamination such as a bright foreground star or significant stray light from stars in the IRAC scattering zones. Then we chose barred galaxies from all Hubble types from S0 to Sdm using the numerical Hubble types from Hyperleda (Paturel et al. 2003, cat. VII/237, VII/238). The assessment of the presence of a bar was done visually by K. Sheth, T. Kim, and B. de Swardt. Later, we also confirmed the presence of a bar by checking the mid-infrared classification (Buta et al. 2010, cat. J/ApJS/190/147; Buta et al. 2015, cat. J/ApJS/217/32). A total of 144 barred galaxies were selected that satisfy our criteria, and we list our sample in Table1 with basic information. Table2 presents the measures of structural parameters for all galaxies in the sample obtained from the 2D model fit with BUDDA (BUlge/disk Decomposition Analysis, de Souza et al., 2004ApJS..153..411D; Gadotti, 2008MNRAS.384..420G) code. (2 data files).

  10. Photocathodes based on semiconductor superlattices for streak tubes for IR region of 0.9-1.0 um

    NASA Astrophysics Data System (ADS)

    Nolle, Eduard L.

    1995-05-01

    A possibility of temporal analysis of picosecond light pulses in the IR region with the help of photocathodes based on semiconductor superlattices (SL) of type I (InP/InGaAs) with Schottky barrier is discussed. A new principle of avalanche photoelectron emission from such an SL at interband absorption of light is suggested. The principle is based on the electrons free length path increasing in a SL with narrow quantum wells under high electric field applied to the SL. The idea makes it possible to develop a new device - avalanche photocathode with internal amplification for the IR region of 0.9-2 micrometers and temporal resolution better than 30 ps. It is proposed to use doped as well as undoped SL as basis for photocathodes sensitive to the IR radiation in the range of up to 10 micrometers . The photoemission from such structures is caused by the intersubband absorption of light in quantum wells. The use of undoped SL greatly reduced the thermoemission current of the photocathode but requires additional excitation of the SL by light pulses with energy approximately corresponding to the band gap of the narrow band gap material of the SL. The temporal resolution of such photocathodes is supposed to be less than 30 ps. The conditions for the avalanche photoelectron emission obtaining are determined, and the SL parameters which meet the requirement of maximum quantum efficiency of the photocathode are calculated.

  11. 1.9-um diode-laser-assisted anastomoses in reconstructive microsurgery: preliminary results in 12 patients

    NASA Astrophysics Data System (ADS)

    Mordon, Serge R.; Schoffs, Michel; Martinot, Veronique L.; Buys, Bruno; Patenotre, Philippe; Lesage, Jean C.; Dhelin, Guy

    1998-01-01

    The authors reported an original 1.9 micrometer diode laser assisted microvascular anastomosis (LAMA) in human. This technique has been applied in 12 patients during reconstructive surgery for digital replantations (n equals 2), for digital revascularizations (n equals 3) and for free flap transfers (n equals 7). Fourteen end-to-end anastomoses (10 arteries, 4 veins) were performed. LAMA were always performed on vessel which did not impede the chance of success of the surgical procedure in case of thrombosis. LAMA was performed with a 1.9 micrometer diode laser after placement of 2 equidistant stitches. The didoes spot was obtained by means of an optic fiber transmitted to the vessel wall via a pencil size hand piece. The used parameters were as followed: spot size equals 400 micrometer, power equals 70 to 220 mW, time equals 0.7 to 2 seconds, mean fluence equals 115 J/cm2. The mechanism involved is a thermal effect on the collagen of the adventitia and media leading to a phenomena which the authors have termed 'heliofusion.' This preliminary trial has permitted to define the modalities of its use in human. The technique is simple, rapid and easily learned. The equipment is not cumbersome, sterilizable and very ergonomic. LAMA does not replace sutures but is complementary, thanks to a reduction in the number of stitches used and to an access to surgical areas which are not easily accessible. This study must be completed by a larger scale study to confirm this technique and its reliability. Others uses could performed on different tissues such as biliary and urinary track, specially under laparoscopic conditions.

  12. Espectroscopia infravermelha para a determinacao de carbono do solo: Perspectiva de um metodo economicamente viavel e ambientalmente seguro

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Kyoto Protocol is an agreement among many of the world’s nations to, among other things, reduce atmospheric carbon dioxide concentrations in order to reduce global warming. One potential method to do so is to sequester carbon in soils. This has had the effect of stimulating the establishment of ...

  13. Elemental analysis of natural quartz from Um Higlig, Red Sea Aea, Egypt by instrumental neutron activation analysis.

    PubMed

    El-Taher, A; Alharbi, Abdulaziz

    2013-12-01

    A scheme for INAA of 25 elements: As, Ba, Ca, Ce, Co, Cr, Cs, Eu, Fe, Hf, K, La, Lu, Mg, Mn, Na, Nd, Rb, Sc, Sm, Th, U, Yb, Zn and Zr in quartz collected from the eastern desert along the Egyptian Red Sea coast is proposed. The samples were prepared together with standard reference material and irradiated in a neutron flux of 7×10(11)n/cm(2)s in the TRIGA Mainz research reactor facilities. The gamma spectra were collected by a HPGe detector and the analysis was done by a computerized multichannel analyzer.The accuracy of the procedure is evaluated by the analysis of two geo-standard reference materials (Dolerite WSE and Microgabro PMS). The choice of the nuclear reaction, irradiation and decay times and of the proper gamma radiation in counting are presented and discussed. The data presented here are our contribution to understanding the elemental composition of the quartz rock. Because there are no existing databases for the elemental analysis of quartz, our results are a start to establishing a database for the Egyptian quartz. It is hoped that the data presented here will be useful to those dealing with geochemistry, quartz chemistry and related fields. PMID:23954747

  14. Design of a new 1-5.5-um infrared camera for the NASA Infrared Telescope Facility

    NASA Astrophysics Data System (ADS)

    Rayner, John T.; Shure, Mark A.; Toomey, Douglas W.; Onaka, Peter M.; Denault, Anthony J.; Stahlberger, Werner E.; Watanabe, Darryl; Criez, K.; Robertson, L.; Cook, D.; Kidger, Michael J.

    1993-10-01

    The design of a multipurpose 1 - 5.5 micrometers infrared camera (NSFCAM) for the NASA Infrared Telescope Facility (IRTF) on Mauna Kea, Hawaii, is described. The camera is built around the new 256 X 256 InSb array manufactured by Santa Barbara Research Center (SBRC) and incorporates a variety of observing modes to fulfill its role as a major facility instrument. These include three remotely-selectable image scales, a selection of fixed bandpass filters, R equals 50 - 100 spectral resolution circularly variable filters, a grism, coronographic masks, and a polarization imaging capability. Through the use of flexible array clocking schemes, driven by programmable digital signal processors (DSPs), we plan to implement several new operating modes, including real-time shift and add for image stabilization, and fast subarray readouts for occultations. Simultaneous optical and infrared imaging of the same field will be possible through the use of a cold dichroic beamsplitter. This feature is primarily intended for use with the IRTF tip-tilt image stabilization system currently being built. Given a suitable guide star, the camera should achieve near-diffraction limited imaging at 2 - 5 micrometers . In this paper we discuss the design of the optics, cryogenic, electronics and software needed to provide the camera with these capabilities.

  15. Epitaxial growth of HgCdTe 1.55-um avalanche photodiodes by molecular beam epitaxy

    NASA Astrophysics Data System (ADS)

    de Lyon, Terence J.; Baumgratz, B.; Chapman, G. R.; Gordon, E.; Hunter, Andrew T.; Jack, Michael D.; Jensen, John E.; Johnson, W.; Johs, Blaine D.; Kosai, K.; Larsen, W.; Olson, G. L.; Sen, M.; Walker, B.

    1999-04-01

    Separate absorption and multiplication avalanche photodiode (SAM-APD) device structures, operating in the 1.1 - 1.6 micrometer spectral range, have been fabricated in the HgCdTe material system by molecular-beam epitaxy. These HgCdTe device structures, which offer an alternative technology to existing III-V APD detectors, were grown on CdZnTe(211)B substrates using CdTe, Te, and Hg sources with in situ In and As doping. The alloy composition of the HgCdTe layers was adjusted to achieve both efficient absorption of IR radiation in the 1.1 - 1.6 micrometer spectral range and low excess-noise avalanche multiplication. To achieve resonant enhancement of hole impact ionization from the split-off valence band, the Hg(subscript 1-x)Cd(subscript x)Te alloy composition in the gain region of the device, x equals 0.73, was chosen to achieve equality between the bandgap energy and spin-orbit splitting. The appropriate value of this alloy composition was determined from analysis of the 300 K bandgap and spin-orbit splitting energies of a set of calibration layers, using a combination of IR transmission and spectroscopic ellipsometry measurements. MBE-grown APD epitaxial wafers were processed into passivated mesa-type discrete device structures and diode mini-arrays using conventional HgCdTe process technology. Device spectral response, dark current density, and avalanche gain measurements were performed on discrete diodes and diode mini- arrays on the processed wafers. Avalanche gains in the range of 30 - 40 at reverse bias of 85 - 90 V and array-median dark current density below 2 X 10(superscript -4) A/cm(superscript 2) at 40 V reverse bias have been demonstrated.

  16. Modeling the language learning strategies and English language proficiency of pre-university students in UMS: A case study

    NASA Astrophysics Data System (ADS)

    Kiram, J. J.; Sulaiman, J.; Swanto, S.; Din, W. A.

    2015-10-01

    This study aims to construct a mathematical model of the relationship between a student's Language Learning Strategy usage and English Language proficiency. Fifty-six pre-university students of University Malaysia Sabah participated in this study. A self-report questionnaire called the Strategy Inventory for Language Learning was administered to them to measure their language learning strategy preferences before they sat for the Malaysian University English Test (MUET), the results of which were utilised to measure their English language proficiency. We attempted the model assessment specific to Multiple Linear Regression Analysis subject to variable selection using Stepwise regression. We conducted various assessments to the model obtained, including the Global F-test, Root Mean Square Error and R-squared. The model obtained suggests that not all language learning strategies should be included in the model in an attempt to predict Language Proficiency.

  17. Chemical optimization of resist/developer systems tuned for sub-0.4-um process window expansion

    NASA Astrophysics Data System (ADS)

    Toukhy, Medhat A.; Schlicht, Karin R.; Tarbox, Kimberly

    1997-07-01

    In order to perform 0.2 micrometer processes, one needs to study the diffusion of photoacid generators within the photoresist system, since diffusion during post exposure bake time has an influence on the critical dimension (CD). We have developed a new method to study the diffusion of photoacid generators within a polymer film. This new method is based on monitoring the change of the fluorescence intensity of a pH- sensitive fluorescent dye caused by the reaction with photoacid. A simplified version of this experiment has been conducted by introducing acid vapor to quench the fluorescence intensity of this pH sensor. A thin polymer film is spin cast onto the sensor to create a barrier to the acid diffusion process. During the acid diffusion process, the fluorescence intensity of this pH sensor is measured in situ, using excitation and emission wavelengths at 466 nm and 516 nm, respectively. Fluoresceinamine, the pH sensitive fluorescent dye, is covalently bonded onto the treated quartz substrate to form a single dye layer. Poly(hydroxystyrene) (Mn equals 13k, Tg equals 180 degrees Celsius) in PGMEA (5% - 18% by weight) is spin cast onto this quartz substrate to form films with varying thickness. The soft bake time is 60 seconds at 90 degrees Celsius and a typical film has a thickness of 1.4 micrometers. Trifluoroacetic acid is introduced into a small chamber while the fluorescence from this quartz window is observed. Our study focuses on finding the diffusion constant of the vaporized acid (trifluoroacetic acid) in the poly(hydroxystyrene) polymer film. By applying the Fick's second law, (It - Io)/(I(infinity ) - Io) equals erfc [L/(Dt)1/2] is obtained. The change of fluorescence intensity with respect to the diffusion time is monitored. The above equation is used for the data analysis, where L represents the film thickness and t represents the average time for the acid to diffuse through the film. The diffusion constant is calculated to be at the order of 10-10 cm2/s to 10-12 cm2/s. All the experiments are conducted at room temperature and are valid only for acid vapor. With different film thickness, it was found that the acid diffuses through the film with a similar diffusion constant. The diffusion is faster with increased solvent residue in the film (controlled by spin coating speed). The theoretical computer modeling of the local acid concentration with respect to acid diffusion is also performed.

  18. Room temperature continuous wave InGaAsN quantum well vertical cavity lasers emitting at 1.3 um

    SciTech Connect

    CHOQUETTE,KENT D.; KLEM,JOHN F.; FISCHER,ARTHUR J.; SPAHN,OLGA B.; ALLERMAN,ANDREW A.; FRITZ,IAN J.; KURTZ,STEVEN R.; BREILAND,WILLIAM G.; SIEG,ROBERT M.; GEIB,KENT M.; SCOTT,J.W.; NAONE,R.L.

    2000-06-05

    Selectively oxidized vertical cavity lasers emitting at 1294 nm using InGaAsN quantum wells are reported for the first time which operate continuous wave at and above room temperature. The lasers employ two n-type Al{sub 0.94}Ga{sub 0.06}As/GaAs distributed Bragg reflectors each with a selectively oxidized current aperture adjacent to the optical cavity, and the top output mirror contains a tunnel junction to inject holes into the active region. Continuous wave single mode lasing is observed up to 55 C. These lasers exhibit the longest wavelength reported to date for vertical cavity surface emitting lasers grown on GaAs substrates.

  19. Genetic mapping of MlUM15: an Aegilops neglecta-derived powdery mildew resistance gene in common wheat

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Powdery mildew, caused by Blumeria graminis DC f. sp. tritici, is a major fungal disease of wheat (Triticum aestivum L.) in cool and humid climates. Race-specific host plant resistance is a reliable, economical, and environmentally benign form of disease prevention. The identification of molecular m...

  20. Near-achromatic retardance behavior of HN22 Polaroid 3.6 to 5.4 um

    NASA Astrophysics Data System (ADS)

    Lompado, Arthur; Sornsin, Elizabeth A.; Chipman, Russell A.

    1997-10-01

    Polaroid HN22, a popular sheet polarizer, has been measured to be a nearly half wave retarder in the 3.6 to 5.4 micrometers spectral band with a transmittance of approximately 20 percent. The exact retardance value may be tuned to the range of 60 degrees - 260 degrees by tilting the HN22 with respect to the incident beam. The material's polarizing effects have been shown to be minimal in this waveband. Its availability, relatively large available aperture, large filed of view, and low cost make HN22 an excellent candidate for use as an IR retarder for systems operating from 3.6 to 5.4 micrometers . As such, HN22 may be used for rotating the plane of polarization of an incident linearly polarized beam as well as to convert between circular polarization states.

  1. High resolution analysis of the ethylene-1-13C spectrum in the 8.4-14.3 um region

    SciTech Connect

    Flaud, Jean Marie; Lafferty, Walter J.; Sams, Robert L.; Devi, V. M.

    2010-01-29

    Fourier transform spectra of mono-13C ethylene have been recorded in the 8.4-14.3- μm spectral region (700 cm-1 to 1190 cm-1) using a Bruker 120 HR interferometer at a resolution of 0.0017 cm-1 allowing the extensive study of the set of resonating states {101, 81, 71,41,61}. Due to the high resolution available as well as the extended spectral range involved in this study, a much larger set of line assignments are now available. The present analysis has leads to the determination of more accurate spectroscopic constants including interaction constants than were obtained in earlier studies. In particular, the following band centers were derived: ν0(ν10) = 825.40602(30) cm-1, ν0(ν8) = 932.19572(15) cm-1, ν0(ν7) = 937.44452(10) cm-1, ν0(ν4) = 1025.6976(14) cm-1. Finally a synthetic spectrum was generated leading to the assignment of a number of 13C12CH4 lines observed through an earlier heterodyne spectroscopic study.

  2. Cozinha: Um Lugar para a "bildung" dos Educadores (The Kitchen: A Place for the "bildung" of Educators).

    ERIC Educational Resources Information Center

    Damiano, Gilberto

    2000-01-01

    Uses a kitchen metaphor for philosophy of education, in dialogue with Augustine, Erasmus of Rotterdam, Brillat-Savarin, and others. Mixes and cooks ingredients in thinking: the centrality of the human being, corporeality, historicity, and transcendency; food as sign-symbol; eating-linguistic habits; educator-cook; space of the kitchen; sensuality,…

  3. CONTINUOUS MEASUREMENT OF PARTICLES (0.01-20.0 UM) IN AN OCCUPIED HOME, REED AND WALLACE, AAAR.

    EPA Science Inventory

    To better understand the contribution of outdoor and indoor sources to particle concentrations found in residential indoor air, an extensive monitoring effort has been undertaken in a three-story townhouse located in Reston, VA. Of particular interest was the determination of i...

  4. Spectral Irradiance Calibration in the Infrared. 4; 1.2-35um Spectra of Six Standard Stars

    NASA Technical Reports Server (NTRS)

    Cohen, Martin; Witteborn, Fred C.; Walker, Russell G.; Bregman, Jesse D.; Wooden, Diane H.

    1995-01-01

    We present five new absolutely calibrated continuous stellar spectra from 1.2 to 35 microns, constructed as far as possible from actual observed spectral fragments taken from the ground, the Kuiper Airborne Observatory (KAO), and the IRAS Low Resolution Spectrometer (LRS). These stars, Beta Peg, Delta Boo, Beta And, Beta Gem, and Delta Hya, augment our already created complete absolutely calibrated spectrum for a Tau. All these spectra have a common calibration pedigree. The wavelength coverage is ideal for calibration of many existing and proposed ground-based, airborne, and satellite sensors.

  5. The relationship between English language learning strategies and proficiency of pre-university students: A study case of UMS

    NASA Astrophysics Data System (ADS)

    Kiram, Johannah Jamalul; Sulaiman, Jumat; Swanto, Suyansah; Din, Wardatul Akmam

    2014-07-01

    This paper seeks to investigate the relationship between language learning strategies and proficiency in English. Fifty-six pre-university students (22 males, 34 females) of University Malaysia Sabah participated in this study. Oxford's Strategy Inventory for Language Learning (SILL) self-report questionnaire was adopted to identify the students' language learning strategies, whereas their proficiencies were judged based on their Malaysian University English Test (MUET) Results. Pearson's correlation coefficient, Spearman's rank correlation coefficient and the t-test were utilized to make statistical interpretation about the relationship. The knowledge obtained from this study will be helpful for future studies on how to improve the quality of learning and proficiency in English.

  6. Substrate-removed 850-nm RCLEDs and small core (63/125 um) plastic optical fibers for optical data communication

    NASA Astrophysics Data System (ADS)

    Coosemans, Thierry; Bockstaele, Ronny; Van Hove, An; Naessens, Kris; Derluyn, Joff; Vanwassenhove, Luc; Van Daele, Peter; Moerman, Ingrid; Baets, Roel G.

    2000-04-01

    Current developments in computer technology give rise to increasing data communication over relatively short distances at backplane- and inter MCM interconnect level. It is foreseen that electrical interconnect will not be able to accommodate the necessary data traffic in advanced data processing systems in the future and hence a bottleneck will be created. A potential remedy for this interconnect problem is the use of parallel optical datalinks. In this paper we propose small diameter step index plastic optical fiber ribbons in combination with high efficient resonant cavity LED's as a cheap and feasible option for these optical links. A design for such an optical link is presented with special attention for the optical pathway. Experimental results on the optical properties of the used POF are shown. We describe the development of RCLED's at 850 nm specially designed for efficient coupling into POF. We measured a RCLED to POF coupling efficiency up to 40%. Additionally we report on the technologies used for the fabrication and assembly of the optical pathways and finally some experiments were carried out on the first realized assemblies.

  7. Network as transconcept: elements for a conceptual demarcation in the field of public health.

    PubMed

    Amaral, Carlos Eduardo Menezes; Bosi, Maria Lúcia Magalhães

    2016-06-10

    The main proposal to set up an articulated mode of operation of health services has been the concept of network, which has been appropriated in different ways in the field of public health, as it is used in other disciplinary fields or even taking it from common sense. Amid the diversity of uses and concepts, we recognize the need for rigorous conceptual demarcation about networks in the field of health. Such concern aims to preserve the strategic potential of this concept in the research and planning in the field, overcoming uncertainties and distortions still observed in its discourse-analytic circulation in public health. To this end, we will introduce the current uses of network in different disciplinary fields, emphasizing dialogues with the field of public health. With this, we intend to stimulate discussions about the development of empirical dimensions and analytical models that may allow us to understand the processes produced within and around health networks. RESUMO A principal proposta para configurar um modo articulado de funcionamento dos serviços de saúde tem sido o conceito de rede, que vem sendo apropriado de diferentes formas no campo da saúde coletiva, conforme seu emprego em outros campos disciplinares ou mesmo tomando-o do senso comum. Em meio à pluralidade de usos e concepções, reconhecemos a necessidade de rigorosa demarcação conceitual acerca de redes no campo da saúde. Tal preocupação visa a preservar o potencial estratégico desse conceito na investigação e planificação no campo, superando precariedades e distorções ainda observadas em sua circulação discursivo-analítica na saúde coletiva. Para tanto, apresentaremos os usos correntes de rede em diferentes campos disciplinares, destacando interlocuções com o campo da saúde coletiva. Com isso, pretendemos estimular o debate acerca do desenvolvimento de dimensões empíricas e modelos de análise que permitam compreender os processos produzidos no interior e ao redor

  8. Qual o Papel da Escola e da Mídia na Obtenção dos Conhecimentos Astronômicos?

    NASA Astrophysics Data System (ADS)

    da Cunha, W. S.; Voelzke, M. R.; Amaral, L. H.

    2007-08-01

    É amplamente reconhecido que as pessoas em geral têm grande fascínio e interesse pela Astronomia. Por outro lado, o conteúdo dessa área incluído no ensino formal está longe de ser abrangente e suficiente para suprir a demanda. Esse interesse permite aperfeiçoar a divulgação e o ensino não formal de Astronomia através da mídia aliando a adequação do conteúdo à expectativa das pessoas. A reforma do Currículo Básico da Escola Pública da maioria dos Estados brasileiros tem introduzido Astronomia desde a pré-escola até o Ensino Médio. Num estudo realizado com 1180 alunos do Ensino Médio de seis escolas estaduais, revelou-se através da aplicação de um formulário contendo questões que abordavam conhecimentos básicos em Astronomia, como foram adquiridos tais conhecimentos e à infra-estrutura da escola. Para 66,1% dos entrevistados o professor já fez alguma apresentação a respeito de Astronomia. O presente estudo revelou também que 54,4% dos alunos entrevistados adquiriram seus conhecimentos astronômicos na escola, 18,4% através da televisão e 27,1% afirmaram que seus conhecimentos foram obtidos através de outros tipos de mídia (internet, livros didáticos, filmes e revistas). Embora o estudo revele claramente que há certo equilíbrio no meio em que os alunos obtiveram seus conhecimentos astronômicos, a mídia busca não somente sua difusão, mas a disponibilização desse conhecimento de maneira correta, que às vezes, não é atingido, apresentando conceitos sem fundamentação e incorretos. Por outro lado, no dia-a-dia escolar, é comum encontrar professores que vêm para as aulas com concepções prévias, que podem diferir substancialmente das idéias a serem ensinadas, dificultando o aprendizado de futuros conceitos científicos. Uma avaliação criteriosa, avaliando as dificuldades dos professores em determinar o sentido correto dos conceitos e observando a metodologia que utilizam no ensino, poderá proporcionar uma melhor

  9. Diferentes metodologias aplicadas ao ensino de astronomia no Ensino Médio

    NASA Astrophysics Data System (ADS)

    Albrecht, E.; Voelzke, M. R.

    2009-03-01

    O presente trabalho de intervenção foi realizado junto à Escola Estadual Colònia dos Pescadores na cidade de Caraguatatuba, com très turmas do terceiro ano do Ensino Médio, envolvendo 119 alunos com idades entre 16 e 19 anos. A fase inicial foi composta de um questionário de vinte questíes dissertativas e objetivas, aplicado pelo professor titular da sala, que era o mesmo nas très turmas, para diagnosticar nos educandos os conceitos prévios sobre Astronomia e, partindo destes realizar um trabalho de intervenção nas classes envolvidas utilizando, em cada uma, metodologias diferentes: (A) sob forma de seminários, elaborados e apresentados pelos educandos, no qual o educador faz apenas as intervençíes necessárias; (B) de forma tradicional, com auxílio de multimídias para desenvolvimento das aulas e a terceira (C) tradicional, fazendo uso exclusivo de lousa e giz. Ao final do trabalho os alunos responderam novamente o questionário inicial para diagnosticar dentre as très metodologias utilizadas qual apresentou melhores aplicaçíes, os resultados iniciais foram comparados com os finais. Quando questionados a respeito do significado de Astronomia observou-se inicialmente que os acertos na turma A foram de 100%, turma B: 64%, turma C: 84%, após a intervenção os acertos foram: 100%, 97% e 85% respectivamente, demonstrando que houve um avanço significativo na turma B, a turma A manteve seu índice e a turma C evoluiu, porém não tanto quanto a B. Quando interrogados sobre quantos planetas vocè acha que existem em nosso Sistema Solar? os acertos foram: turma A: 39%, turma B: 48% e turma C: 46%, após o desenvolvimento do trabalho os acertos foram 94%, 97% e 90% respectivamente. Dentro das respostas obtidas observa-se que a metodologia tradicional com o auxílio de multimeios, aplicada na turma B, demonstrou melhores resultados, sendo a mais significativa. Outra conclusão muito importante é que apesar de o tema Astronomia ser amplamente

  10. A cosmologia no ensino da geografia

    NASA Astrophysics Data System (ADS)

    Santos, S. C.; Chiaradia, A. P. M.

    2003-08-01

    O principal objetivo deste trabalho é auxiliar o professor de Geografia em sala de aula no ensino de tópicos relacionados com a Cosmologia. A idéia deste trabalho surgiu quando foi constatado que o professor de Geografia tem dificuldades de ensinar este tópico. Esta constatação foi feita por uma das autoras ao lecionar este tópico no ensino fundamental e em discussões com outros professores de Geografia. Da mesma maneira que ocorria desde os tempos mais antigos, os alunos têm muito interesse em conhecer os fenômenos que ocorrem no Cosmo, porém os livros didáticos de Geografia utilizados em sala de aula não são ricos em informações sobre este assunto. Assim, o professor de Geografia tem poucas informações para discutir este assunto em sala de aula e não dá a devida importância para este tópico. Então, foi desenvolvido um material de apoio para professores de Geografia sobre a origem do Universo, sua evolução e seu possível futuro evolutivo segundo as mais recentes teorias, com base em perguntas feitas pelos alunos de ensino fundamental e as informações trazidas nos livros didáticos Não cabe a este material inovar e tão pouco trazer uma metodologia de ensino de Cosmologia. Neste material o professor de Geografia pode encontrará um banco de informações, que constitui no estabelecimento de conceitos, teorias e hipóteses, sobre a Cosmologia, em linguagem simples e de fácil entendimento. Para desenvolvê-lo, foram feitas pesquisas não exaustivas em livros e revistas científicas, compilação e discussão em forma cronológica das teorias aceitas sobre modelos cosmológicos. Portanto, este material será apresentado neste trabalho.

  11. Ensino de Astronomia no Ensino Médio

    NASA Astrophysics Data System (ADS)

    Albrecht, E.; Voelzke, M. R.

    2008-09-01

    O presente trabalho de intervenção foi realizado junto a Escola Estadual Colônia dos Pescadores na cidade de Caraguatatuba, com três turmas do terceiro ano do Ensino Médio, envolvendo 119 alunos, 40 na turma A, 40 na turma B e 39 na turma C. A fase inicial foi composta de um questionário de vinte questões dissertativas e objetivas para diagnosticar nos educandos os conceitos prévios sobre Astronomia e, partindo destes realizar uma interferência nas classes envolvidas utilizando metodologias diferentes sendo elas: a tradicional, onde o professor é um repassador de informações, fazendo uso exclusivo de lousa e giz; a segunda também de forma tradicional, porém com auxílio de multimídia para desenvolvimento das aulas e a terceira sob forma de seminários, elaborados e apresentados pelos educandos, no qual o educador faz apenas as intervenções necessárias. Ao final do trabalho as mesmas turmas da fase inicial orientadas pelo mesmo professor responderam novamente ao questionário proposto para diagnosticar dentre as três metodologias utilizadas qual apresentou melhores resultados, sendo os iniciais comparados com os finais. Quando questionados a respeito do significado de Astronomia observou-se inicialmente que os acertos na turma A foram de 100%,turma B: 64%, turma C: 84%, após a intervenção os acertos foram: 100%, 97% e 85% respectivamente, demonstrando claramente uma absorção de conhecimentos. Quando interrogados sobre quantos planetas você acha que existem em nosso Sistema Solar? os acertos foram: turma A: 39%, turma B: 48% e turma C: 46%, após o desenvolvimento do trabalho os acertos foram 94%, 97% e 90% respectivamente.Dentro das respostas obtidas observa-se que a metodologia tradicional com o auxílio de multimeios, aplicada na turma B, demonstrou melhores resultados, foi a mais significativa.

  12. Capacitacion de educadores para areas marginales--I: Caracteristicas y necesidades educativas de los ninos, jovenes y adultos en las poblaciones menos favorecidas, rurales y urbanas. Tercera edicion (Preparation of Educators for Marginal Areas--I: Educational Needs and Characteristics of Children, Youth and Adults in Disadvantaged Populations, Rural and Urban. Third Edition).

    ERIC Educational Resources Information Center

    Tedesco, Juan Carlos

    Forty percent of the families in Latin America have an income which does not provide essential necessities. Two-thirds of poor families live in the countryside, while the remainder reside in urban slums. The key variable in explaining poverty is education. Without education these families have irregular, unstable, and low paying employment…

  13. Building Adult Relationships: Are You Treated as an Equal in Your Family? (A Pamphlet for People with Disbilities) [and] Como Establecer Relaciones Adultas: Se Lo Trata a UD. Igual que a Los Demas Adultos en Su Familia? (Un Panfleto para las Personas con Impedimentos).

    ERIC Educational Resources Information Center

    Baron, Carla

    Two booklets, in English and Spanish, are addressed to disabled adults and offer guidelines for building adult relationships within the family. Stressed are the importance of feeling good about oneself, learning to make decisions, and developing good communication skills so that family balance is maintained. Also included are lists of the types of…

  14. A Diagnostic Assessment for the Teaching of Astronomy. (Spanish Title: Una Evaluación Diagnóstica Para la Enseñanza de la Astronomia.) Uma Avaliação Diagnóstica Para o Ensino da Astronomia

    NASA Astrophysics Data System (ADS)

    Pacifico Ribeiro de Assis Silveira, Felipa; Soares Gomes de Sousa, Célia Maria; Moreira, Antonio

    2011-07-01

    interpretación, lo que nos permite comprender los significados asignados por el estudiante a estos conceptos. Se desprende de la evaluación diagnóstica que la mayoría de los encuestados ha tenido dificultades para exponer los conceptos científicos sobre el Universo y la Tierra, para iniciar el 6 º grado. Sin embargo, se identificaron ideas relevantes y las representaciones que contribuyeron a la re-significación de los conceptos científicos propuestos para la enseñanza del tema en esta serie. Los resultados de la evaluación diagnóstica han servido como referencia para la organización del Programa, facilitando el proceso de aprendizaje, haciendo coincidir la secuencia didáctica a las características de los estudiantes y el contexto del aula. Se espera que el instrumento presentado en este documento también pueda ser utilizado por otros investigadores en investigaciones relacionadas con el tema. Este artigo tem como objetivo apresentar os resultados de uma avaliação diagnóstica, utilizada como instrumento para a coleta de dados sobre o conhecimento prévio de conceitos científicos, necessários à compreensão do tema Terra e Universo, de um grupo composto por 47 estudantes, da 6ª série do Ensino Fundamental. A ação pedagógica de diagnosticar os conhecimentos prévios, do estudante, antes de ensiná-los, tem fundamento na teoria da Aprendizagem Significativa, proposta por David Ausubel. Essa avaliação diagnóstica foi composta por 25 questões, cujas respostas foram analisadas e categorizadas visando sua interpretação, o que permitiu compreender os significados atribuídos pelo estudante a esses conceitos. Conclui-se, a partir da avaliação diagnóstica, que a maioria dos estudantes pesquisados apresentou dificuldades em expor conceitos científicos sobre o tema Terra e Universo ao iniciar a 6ª série. Entretanto, foram identificadas ideias e representações relevantes que contribuíram para a (re)significação dos conceitos científicos propostos

  15. A Diagnostic Assessment for the Teaching of Astronomy. (Spanish Title: Una Evaluación Diagnóstica Para la Enseñanza de la Astronomia.) Uma Avaliação Diagnóstica Para o Ensino da Astronomia

    NASA Astrophysics Data System (ADS)

    Pacifico Ribeiro de Assis Silveira, Felipa; Soares Gomes de Sousa, Célia Maria; Moreira, Antonio

    2011-07-01

    interpretación, lo que nos permite comprender los significados asignados por el estudiante a estos conceptos. Se desprende de la evaluación diagnóstica que la mayoría de los encuestados ha tenido dificultades para exponer los conceptos científicos sobre el Universo y la Tierra, para iniciar el 6 º grado. Sin embargo, se identificaron ideas relevantes y las representaciones que contribuyeron a la re-significación de los conceptos científicos propuestos para la enseñanza del tema en esta serie. Los resultados de la evaluación diagnóstica han servido como referencia para la organización del Programa, facilitando el proceso de aprendizaje, haciendo coincidir la secuencia didáctica a las características de los estudiantes y el contexto del aula. Se espera que el instrumento presentado en este documento también pueda ser utilizado por otros investigadores en investigaciones relacionadas con el tema. Este artigo tem como objetivo apresentar os resultados de uma avaliação diagnóstica, utilizada como instrumento para a coleta de dados sobre o conhecimento prévio de conceitos científicos, necessários à compreensão do tema Terra e Universo, de um grupo composto por 47 estudantes, da 6ª série do Ensino Fundamental. A ação pedagógica de diagnosticar os conhecimentos prévios, do estudante, antes de ensiná-los, tem fundamento na teoria da Aprendizagem Significativa, proposta por David Ausubel. Essa avaliação diagnóstica foi composta por 25 questões, cujas respostas foram analisadas e categorizadas visando sua interpretação, o que permitiu compreender os significados atribuídos pelo estudante a esses conceitos. Conclui-se, a partir da avaliação diagnóstica, que a maioria dos estudantes pesquisados apresentou dificuldades em expor conceitos científicos sobre o tema Terra e Universo ao iniciar a 6ª série. Entretanto, foram identificadas ideias e representações relevantes que contribuíram para a (re)significação dos conceitos científicos propostos

  16. Morphofunctional variation of the tooth pulp under the action of the erbium laser radiation with the wavelength 2.69 um

    NASA Astrophysics Data System (ADS)

    Balin, Victor N.; Guk, Alexey S.; Jordanishwily, A. K.; Kropotov, Sergey P.; Maday, Dimitry Y.; Kusovkova, Tatyana A.; Serebryakov, Victor A.; Frolov, Sergey V.

    1995-04-01

    The paper presents the investigation results of the morphofunctional state of the mouth cavity tissues after teeth processing by the laser radiation with the wavelength 2.69 micrometers . Teeth preparation down to the state of the deep or intermediate caries as well as pulp trepanation cases are discussed. No pulp necrosis was observed.

  17. Commissioning results of MMT-POL: the 1-5um imaging polarimeter leveraged from the AO secondary of the 6.5m MMT

    NASA Astrophysics Data System (ADS)

    Packham, C.; Jones, T. J.; Warner, C.; Krejny, M.; Shenoy, D.; Vonderharr, T.; Lopez-Rodriguez, E.; DeWahl, K.

    2012-09-01

    MMT-POL is an adaptive optics optimized imaging polarimeter designed for use at the 6.5m MMT. By taking full advantage of the adaptive optics secondary mirror of the MMT, this polarimeter offers diffraction-limited polarimetry with very low instrumental polarization and minimal thermal background. MMT-POL permits observations as diverse as protoplanetary discs, comets, red giant winds, (super)novae and ejecta, galaxies, and AGN. We report on the initial on-sky commissioning results of the instrument including a description of the instrument.

  18. Confusion about a little observatory: the history of the first high school observatory (German Title: Verwirrung um eine kleine Sternwarte: Die Geschichte der ersten Chemnitzer Schulsternwarte )

    NASA Astrophysics Data System (ADS)

    Pfitzner, Elvira

    By means of a small watercolor, painted by a musicologist, the existence of the highschool observatory of Chemnitz was rediscovered. The small observatory was build in 1893 by means of funds and a donation: after WW I it was also used for popular education. During Nazi times, the observatory fell into neglect, and the mechanical damage made it impossible to put it back into operation after WW II The building was torn down in 1964 and forgotten.

  19. Prolegomenos a um estudo da lingua brasileira nos terreiros de origem africana (Prolegomena to a Study of the Brazilian Language of the Voodoo Rites of African Origin).

    ERIC Educational Resources Information Center

    Megenney, William W.

    Determination of the authenticity of lexical items with Sub-Saharan origin in the voodoo rites of candomble and umbanda in Brazil requires establishing a socio-historical basis for the African diaspora and the current configuration of terreiros. The terreiros demonstrate varying linguistic repertoires according to their affiliation with candomble…

  20. Measurements of Diffuse Sky Emission Components in High Galactic Latitudes at 3.5 and 4.9 um Using Dirbe and WISE Data

    NASA Astrophysics Data System (ADS)

    Sano, K.; Kawara, K.; Matsuura, S.; Kataza, H.; Arai, T.; Matsuoka, Y.

    2016-02-01

    Using all-sky maps obtained from the Cosmic Background Explorer/Diffuse Infrared Background Experiment (DIRBE) at 3.5 and 4.9 μm, we present a reanalysis of diffuse sky emissions such as zodiacal light (ZL), diffuse Galactic light (DGL), integrated starlight (ISL), and isotropic residual emission including the extragalactic background light (EBL). Our new analysis, which includes an improved estimate of ISL using the Wide-field Infrared Survey Explorer data, enabled us to find the DGL signal in a direct linear correlation between diffuse near-infrared and 100 μm emission at high Galactic latitudes (| b| \\gt 35^\\circ ). At 3.5 μm, the high-latitude DGL result is comparable to the low-latitude value derived from the previous DIRBE analysis. In comparison with models of the DGL spectrum assuming a size distribution of dust grains composed of amorphous silicate, graphite, and polycyclic aromatic hydrocarbon (PAH), the measured DGL values at 3.5 and 4.9 μm constrain the mass fraction of PAH particles in the total dust species to be more than ˜2%. This was consistent with the results of Spitzer/IRAC toward the lower Galactic latitude regions. The derived residual emission of 8.9 ± 3.4 nWm-2 sr-1 at 3.5 μm is marginally consistent with the level of integrated galaxy light and the EBL constraints from the γ-ray observations. The residual emission at 4.9 μm is not significantly detected due to the large uncertainty in the ZL subtraction, the same as in previous studies. Combined with our reanalysis of the DIRBE data at 1.25 and 2.2 μm, the residual emission in the near-infrared exhibits the Rayleigh-Jeans spectrum.

  1. Derivation of a Large Isotopic Diffuse Sky Emission Component at 1.25 and 2.2um from the COBE/DIRBE Data

    NASA Astrophysics Data System (ADS)

    Sano, K.; Kawara, K.; Matsuura, S.; Kataza, H.; Arai, T.; Matsuoka, Y.

    2015-10-01

    Using all-sky maps obtained with COBE/DIRBE, we reanalyzed the diffuse sky brightness at 1.25 and 2.2 μ {{m}}, which consists of zodiacal light, diffuse Galactic light (DGL), integrated starlight (ISL), and isotropic emission including the extragalactic background light. Our new analysis including an improved estimate of the DGL and the ISL with the 2MASS data showed that deviations of the isotropic emission from isotropy were less than 10% in the entire sky at high Galactic latitude (| b| \\gt 35^\\circ ). We derived the DGL to 100 μm brightness ratios of ∼4.79 and ∼1.49 n W m‑2 MJy‑1 at 1.25 and 2.2 μm, respectively. The result of our analysis revealed a significantly large isotropic component at 1.25 and 2.2 μ {{m}} with intensities of 60.15 ± 16.14 and 27.68+/- 6.21 {{n}} {{W}} {{{m}}}-2 {{sr}}-1, respectively. This intensity is larger than the integrated galaxy light, upper limits from γ-ray observation, and potential contribution from exotic sources (i.e., Population III stars, intrahalo light, direct collapse black holes, and dark stars). We therefore conclude that the excess light may originate from the local universe: the Milky Way and/or the solar system.

  2. Heavy-ion broad-beam and microprobe studies of single-event upsets in 0.20 um SiGe heterojunction bipolar transistors and circuits.

    SciTech Connect

    Fritz, Karl; Irwin, Timothy J.; Niu, Guofu; Fodness, Bryan; Carts, Martin A.; Marshall, Paul W.; Reed, Robert A.; Gilbert, Barry; Randall, Barbara; Prairie, Jason; Riggs, Pam; Pickel, James C.; LaBel, Kenneth; Cressler, John D.; Krithivasan, Ramkumar; Dodd, Paul Emerson; Vizkelethy, Gyorgy

    2003-09-01

    Combining broad-beam circuit level single-event upset (SEU) response with heavy ion microprobe charge collection measurements on single silicon-germanium heterojunction bipolar transistors improves understanding of the charge collection mechanisms responsible for SEU response of digital SiGe HBT technology. This new understanding of the SEU mechanisms shows that the right rectangular parallele-piped model for the sensitive volume is not applicable to this technology. A new first-order physical model is proposed and calibrated with moderate success.

  3. Historia Oral, Experiencias de Aprendizagem e Enraizamento Sociocultural--Um Projeto em Curso (Oral History, Learning Experiences, and Sociocultural Setting--A Project in Process).

    ERIC Educational Resources Information Center

    Vidigal, Luis

    1995-01-01

    Examines education and childhood in Portugal. Uses oral history methods in an educational context, exploring oral statements pedagogically. Considers these statements especially suitable to maintaining aspects of collective memory and social identity, reinforcing students' national and regional identities. Suggests this is very important in…

  4. A temperature-controlled cell for X-ray study of liquid systems using a commercial DRON-UM1 diffractometer

    SciTech Connect

    Petrun`kin, S.P.; Garavina, E.V.; Trostin, V.N.

    1995-02-01

    A container (cell) and a temperature-control system have been designed enabling one to carry out x-ray diffraction study of liquid samples both at a fixed temperature and within a certain temperature range using a commercial DRON-UMl x-ray diffractometer. Special features of the cell and the materials used for it allow one to study both chemically inert and corrosive liquids.

  5. "O Ensaio como Forma" ou Um Ensaio acerca da Teoria Critica da Sociedade ("The Essay as Form" or An Essay about the Critical Theory of Society).

    ERIC Educational Resources Information Center

    Giordano, Rosely

    2000-01-01

    Illuminates the critical theory project, with themes permeating the theoretical constructions of Frankfurt (Germany). Debates the predominance of positivism in the production of knowledge. Speculates that "the essay as form" constitutes itself as a representation of the concept of the Enlightenment. Concludes with a dialogue between Theodor Adorno…

  6. Utilizing contrast enhancement material as a topside antireflective coating (TARC) for maximizing an i-line 0.35-um process window

    NASA Astrophysics Data System (ADS)

    Moynihan, Matthew L.; Markowski, Mark S.

    1995-06-01

    As critical dimensions become smaller, a greater demand is being placed on existing i-line lithographic capability to support 0.35 micrometers technology. One method that is gaining wider acceptance is the use of a top side anti reflective coating (TARC). The effect of the TARC is to reduce the interference effects occurring in the film stack so that critical dimension (CD) variation as a result of topography is minimized. Unfortunately, the TARC provides no improvement with other lithographic responses that define the process window of a resist. Another approach is to use a contrast enhancement material (CEM). It is well known that a CEM can improve the depth of focus and resolution of a given resist system, and it is suspected that it may also possess some of the interference reduction properties of conventional TARCs. The purpose of this work is to investigate how effective the CEM acts as a TARC, and to determine any additional lithographic improvements which will increase the overall 0.35 micrometers process window. Process optimization of the CEM and TARC revealed that similar processing schemes could be used for both materials, but that it was necessary to remove the CEM (w/ a water rinse) prior to post exposure bake (PEB). The bulk photospeed swing ratio of the SPR3000 alone, was compared to SPR3000/Aquatar and SPR3000/CEM. Results showed that the Aquatar reduced the Eo swing ratio by 75%, while the CEM reduced the Eo swing ratio by about 55%. Similar improvements were seen with 0.35 micrometers CD swing ratio data. Exposure latitude and focus latitude (0.35 micrometers lines/spaces) data was generated using the same resist/enhancement schemes mentioned above at thicknesses corresponding to an Emax and Emin. Results of the lithography at each thickness were overlaid to determine the process window. Results showed the Aquatar and CEM processes to provide improved 0.35 micrometers windows, and that using a contrast enhancement material as a TARC is another alternative which can be used to increase the capability of commercially available i-line resists.

  7. Dental hard tissue modification and removal using sealed transverse excited atmospheric-pressure lasers operating at lambda=9.6 and 10.6 um

    NASA Astrophysics Data System (ADS)

    Fried, Daniel; Ragadio, Jerome N.; Akrivou, Maria; Featherstone, John D.; Murray, Michael W.; Dickenson, Kevin M.

    2001-04-01

    Pulsed CO2 lasers have been shown to be effective for both removal and modification of dental hard tissue for the treatment of dental caries. In this study, sealed transverse excited atmospheric pressure (TEA) laser systems optimally tuned to the highly absorbed 9.6 micrometers wavelength were investigated for application on dental hard tissue. Conventional TEA lasers produce an initial high energy spike at the beginning of the laser pulse of submicrosecond duration followed by a long tail of about 1 - 4 microsecond(s) . The pulse duration is well matched to the 1 - 2 microsecond(s) thermal relaxation time of the deposited laser energy at 9.6 micrometers and effectively heats the enamel to the temperatures required for surface modification at absorbed fluences of less than 0.5 J/cm2. Thus, the heat deposition in the tooth and the corresponding risk of pulpal necrosis from excessive heat accumulation is minimized. At higher fluences, the high peak power of the laser pulse rapidly initiates a plasma that markedly reduces the ablation rate and efficiency, severely limiting applicability for hard tissue ablation. By lengthening the laser pulse to reduce the energy distributed in the initial high energy spike, the plasma threshold can be raised sufficiently to increase the ablation rate by an order of magnitude. This results in a practical and efficient CO2 laser system for caries ablation and surface modification.

  8. A Synchrotron-Based Facility for the in-situ Location, Chemical and Mineralogical Characterization of ~10 um Particles Captured in Aerogel

    SciTech Connect

    Flynn, G.; Sutton, S; Lanzirotti, A

    2009-01-01

    NASA's Stardust mission collected dust from the coma of Comet Wild-2 on January 2nd, 2004, by direct capture into aerogel cells that flew through the dust coma at 6 km/s. Stardust collected several hundred comet particles >10 {mu}m in size. These comet samples were delivered to Earth on January 15th, 2006. We developed a facility at the National Synchrotron Light Source at Brookhaven National Laboratory (Upton, NY, USA) for the in-situ characterization of 10 {mu}m particles collected in aerogel. These analytical instruments allow us to perform extensive chemical, mineralogical, and size-frequency characterization of particles captured in aerogel. These analyses are conducted without any invasive extraction, minimizing the possibility of contamination or particle loss during preparation. This facility was used to determine the chemical composition, the oxidation state, the mineralogy and to provide an indication of the grain size of the Wild-2 particles before they were removed from the aerogel. This information provides a catalog of particle types, allowing a more reasoned allocation of the particles to subsequent investigators based on a relatively detailed knowledge of the chemical composition and mineralogy of each particle. These measurements allowed a comparison of the chemical and mineralogical properties of the Wild-2 particles with other types of extraterrestrial materials, including interplanetary dust particles and meteorites. The success of in-situ analysis for Wild 2 particles demonstrates that synchrotron-based facilities will be important for the analysis of particles collected in aerogel on future earth-orbiting satellites and spacecraft.

  9. High Resolution Spectroscopy of H212C16O in the 1.9 to 2.56 um Spectral Range

    SciTech Connect

    Flaud, J-M; Lafferty, Walter J.; Sams, Robert L.; Sharpe, Steven W.

    2006-06-20

    Infrared spectra of H2CO covering the 1.9 ? 2.5 ?m spectral domain have been recorded at very high resolution (0.005 cm-1) using Fourier transform spectroscopy. A thorough analysis of this spectral region has led to the observation and analysis of the v1+v6, v2+v4+v6, 2v3+ v6, v3+v5, v1+v2, v2+v5, 2v2+ v6 and 3v2 bands. The line frequencies were calculated using effective (empirical) Hamiltonian models which account for the main Coriolis and vibrational interactions. Using an interactive scheme it was then possible to least-squares fit the observed energy levels to within a few thousandths of a wavenumber. The Obs. ? Calc. differences do not match the spectral precision ({approx}0.0008 cm-1), but given the congestion in the spectrum resulting from the density of the vibrational states as well as the large centrifugal distortion and Coriolis and anharmonic coupling effects, we believe that a reasonable agreement was obtained.

  10. Antarktische benthische Ostracoden. VIII. Auswertung der Reise der ``Meteor'' (Ant. 11/4) in die Gewässer um Elephant Island und der Antarktischen Halbinsel

    NASA Astrophysics Data System (ADS)

    Hartmann, Gerd

    1992-12-01

    The present paper deals with ostracods collected in Antarctica during the voyage of R.V. “Meteor” (11/4) in December and January 1989/90 in waters around Elephant Island and west of the Antarctic Peninsula between 61° and 67°S and 54° and 69°W. 38 of the 50 species sampled were already known to science, but again 4 new species have been found, while 8 have to remain in open nomenclature. For the first time, a species of the subfamily Paracytherideinae was discovered in Antarctica. Additional material from Cytheropteron insulelephantensis, described by the author (Hartmann, 1989) from Elephant Island and rediscovered now at two further stations, shows that this species has to be placed into the genus Nodobythere. The systematical part of the paper contains the description of the new species and new data for species already previously treated (see Hartmann, 1986 1991), while the list of species and the list of stations (see appendix) contains all the species that were collected.

  11. VizieR Online Data Catalog: Combined ArTeMiS+SPIRE 350um image of NGC6334 (Andre+, 2016)

    NASA Astrophysics Data System (ADS)

    Andre, P.; Reveret, V.; Konyves, V.; Arzoumanian, D.; Tige, J.; Gallais, P.; Roussel, H.; Le Pennec, J.; Rodriguez, L.; Doumayrou, E.; Dubreuil, D.; Lortholary, M.; Martignac, J.; Talvard, M.; Delisle, C.; Visticot, F.; Dumaye, L.; De Breuck, C.; Shimajiri, Y.; Motte, F.; Bontemps, S.; Hennemann, M.; Zavagno, A.; Russeil, D.; Schneider, N.; Palmeirim, P.; Peretto, N.; Hill, T.; Minier, V.; Roy, A.; Rygl, K. L. J.

    2016-05-01

    High dynamic range dust continuum map of the NGC 6334 star-forming complex at 350 microns obtained by combining high-resolution ground-based observations taken with the ArTeMiS camera on the APEX telescope and Herschel Space Observatory data from the HOBYS key project (Motte et al., 2010A&A...518L..77M; Russeil et al. 2013A&A...554A..42R). The effective angular resolution is ~ 8" (HPBW). (2 data files).

  12. Thermodynamic and transport properties of single-crystalline UM Ga5 (M=Fe,Co,Ni,Ru,Rh,Pd,Os,Ir,Pt)

    NASA Astrophysics Data System (ADS)

    Moreno, N. O.; Bauer, E. D.; Sarrao, J. L.; Hundley, M. F.; Thompson, J. D.; Fisk, Z.

    2005-07-01

    We report the results of magnetic susceptibility, specific heat, and electrical resistivity measurements on UMGa5 (M=Fe,Co,Ni,Ru,Rh,Pd,Os,Ir,Pt) single crystals. Antiferromagnetic ordering was observed for M=Ni , Pd, and Pt, with ordering temperatures TN=80K , 28K , and 23.5K , respectively. For the UMGa5 compounds with transition metals from the Fe and Co columns, itinerant paramagnetic behavior is observed. The evolution of this behavior is discussed in terms of f -ligand interaction with an emphasis on the role played by f-d hybridization.

  13. Increased efficiency of silicon light-emitting diodes in a standard 1.2-um silicon complementary metal oxide semiconductor technology

    NASA Astrophysics Data System (ADS)

    Snyman, Lukas W.; Aharoni, Herzl; du Plessis, Monuko; Gouws, Rudolph B.

    1998-07-01

    Scaled versions of a variety of silicon light-emitting diode elements (Si LEDs) have been realized using a standard 1.2- micrometers , double-polysilicon, double-metal, n-well CMOS fabrication process. The devices operated with a n+p junction biased in the avalanche breakdown mode and were realized by using standard features of the ORBIT FORESIGHT design rules. The elements emit optical radiation in a broad band in the 450- to 850-nm range. An emitted intensity of up to 7.1 (mu) W/cm2 has been obtained with 5 mA of current at an operating voltage of 18.5 V. Excellent uniformity in emission intensity of better than 1 percent variation was obtained over areas as large as 100 X 500 micrometers . A best power conversion efficiency of 8.7 X 10-8 and a quantum efficiency of 7.8 X 10-7 were measured. All of these values are about one order of magnitude better than previously reported values for Si LED avalanche devices. Coupling between the elements as well as electro- optical coupling between an element and an optical fiber was realized.

  14. Leo de Ball and his contributions to international astronomical projects around 1900. (German Title: Leo de Ball und seine Beiträge zu internationalen Astronomieprojekten um 1900)

    NASA Astrophysics Data System (ADS)

    Habison, Peter

    From 1891 until 1916 Leo de Ball was the director of the Kuffner Observatory in Vienna. Born in Germany in 1853, he studied at Berlin and Bonn. After having received his doctorate in 1877, he became assistant at Gotha. From 1881 to 1882 he worked at the observatory in Bothkamp, where he discovered the minor planet ``Athamantis''. In 1883, he followed an invitation to the Ougrée Observatory in Belgium. Here he published some quite remarkable papers on the mass of Saturn and was also introduced to meridian circle astronomy. In 1891 he received a call to Moriz von Kuffner's observatory in Vienna. During that time the Astronomische Gesellschaft called for an extension of the ``Zonenunternehmen'' to southern declinations from -2 ° to -23°. De Ball took over the zone -5°50´ to -10°50´. This work occupied most of his time from 1892 to 1896. In 1900 Leo de Ball initiated a project for determining relative parallaxes of 252 stars in collaboration with four observatories. Although the project was only partly executed, Leo de Ball published relative parallaxes of 16 stars, observed from 1901 to 1907 with the Vienna heliometer.

  15. Percepção Astronômica de Alunos do Ensino Médio da Rede Estadual de São Paulo

    NASA Astrophysics Data System (ADS)

    de Oliveira, E. F.; Voelzke, M. R.; Amaral, L. H.

    2005-08-01

    Embora a astronomia seja uma das ciências mais antigas da humanidade e muitos dos conceitos astronômicos serem populares, principalmente nesta época de alta globalização do conhecimento por intermédio de eficientes meios de comunicação e de obtenção da informação, notadamente através da internet, observa-se que uma parcela significativa dos estudantes encontra-se à margem dessas informações. O presente trabalho visa analisar o nível de conhecimento básico dos alunos de Ensino Médio da rede estadual da cidade de Suzano quanto aos fenômenos astronômicos que os rodeiam, tais como a sucessão dos dias e das estações do ano, além de questioná-los sobre fatos genéricos tais como: quais são os astros que se encontram mais próximos do planeta Terra, o que vem a ser o Sol, o Big Bang, um ano-luz, uma estrela cadente, a estrela de Bélem e o que ocasionou a extinção dos dinossauros. Para tanto foi elaborado um formulário constando de questões de múltipla escolha, o qual foi aplicado no primeiro colegial noturno da Escola Estadual Batista Renzi. Num espaço amostral de 34 alunos constatou-se que apenas 29,4% compreendiam a sucessão dos dias da semana, que apenas 20,6% explicaram corretamente as estações do ano, que apenas 20,6% tinham idéia de quais são os objetos celestes mais próximos da Terra, em contraposição 67,6% sabiam classificar corretamente o Sol como estrela, 55,9% relacionavam o Big Bang à origem do universo, apenas 20,6% identificavam um ano-luz como unidade de distância, 32,4% reconheciam uma estrela cadente como meteoro, 41,2% consideravam a estrela de Belém como um cometa e 50,0% explicaram corretamente a extinção dos dinossauros. A presente análise será expandida para as demais classes de primeiro colegial, não somente do período noturno, mas também do diurno da Escola Estadual Batista Renzi, bem como o formulário será devidamente ampliado. Já nesta primeira fase nota-se claramente o pequeno discernimento

  16. What Vaccines Do You Need?

    MedlinePlus

    ... Why Immunize? Vaccines: The Basics Adolescent and Adult Vaccine Quiz Recommend on Facebook Tweet Share Compartir Españ ... adolescentes y adultos Did you know that certain vaccines are recommended for adults and adolescents?* Take this ...

  17. Astronomy in the Classroom: Why? (Spanish Title: Astronomía en la Clase: ¿Por Qué?) Astronomia na Sala de Aula: Por Quê?

    NASA Astrophysics Data System (ADS)

    Daros Gama, Leandro; Bagdonas Henrique, Alexandre

    2010-07-01

    particular, é foco deste ensaio: a astronomia. Em que sentido e em que medida valeria a pena abordá-la em aulas, seja de ciências, seja de astronomia especificamente, ou em disciplinas afins? Discutimos neste texto alguns aspectos das vantagens de se tratar essa área do conhecimento nas escolas, levando em conta as dimensões epistemológica e axiológica da astronomia, à luz da visão da ciência como um diálogo inteligente com o mundo, de Bachelard, além da proposta de problematização do conhecimento, de Paulo Freire. Proporemos que de fato a astronomia não precisa ser vista como apenas um novo conjunto de conteúdos a serem ensinados, mas figura como conjunto de temas motivadores para discussões histórico-filosóficas, além de permitir a abordagem de conceitos típicos de outras disciplinas.

  18. The Moon Phases in a Paper Box. (Spanish Title: Las Fases de la Luna en Una Caja de Cartón.) As Fases da Lua Numa Caixa de Papelão

    NASA Astrophysics Data System (ADS)

    de Fátima O. Saraiva, Maria; Amador, Cláudio B.; Kemper, Érico; Goulart, Paulo; Muller, Angela

    2007-12-01

    material didático de baixo custo para demonstração do conceito de fases de um corpo iluminado. O principal objetivo de nosso material é facilitar a compreensão das fases da Lua da perspectiva de um observador na Terra. O material ajuda na visualização de dois efeitos importantes: (1º) mesmo tendo sempre a metade da "Lua" (representada por uma bolinha de isopor ou de ping-pong) iluminada pelo "Sol" (representado por uma fonte de luz natural ou artificial), nós vemos diferentes frações de sua superfície iluminada, dependendo do ângulo pelo qual a olhamos; (2º) a orientação da borda convexa da Lua nas fases Crescente e Minguante também depende da perspectiva pela qual a olhamos da Terra. O uso de uma caixa fechada permite observar o contraste entre as diferentes fases sem necessidade de estar em uma sala escurecida. Apresentamos também um texto explicativo sobre fases da Lua, enfatizando a dependência da aparência da parte iluminada com o ângulo de visada.

  19. Astronomy, Art and Mythology in a Public Elementary School in Itaocara/rj. (Spanish Title: Astronomía, Arte y Mitologia en el Ensino Fundamental en Una Escuela de la Red Estatal en ITAOCARA/RJ.) Astronomia, Arte e Mitologia no Ensino Fundamental em Escola da Rede Estadual em ITAOCARA/RJ

    NASA Astrophysics Data System (ADS)

    Oliveira Bernardes, Adriana; Ramos dos Santos, Arleidimar

    2008-12-01

    conocimientos recibidos. El trabajo en sí ha mostrado además de la posibilidad de la inclusión de la Astronomía en la Educación Primaria, la posibilidad de un trabajo interdisciplinario en los niveles iniciales incluyendo Astronomía, Arte y Mitología. Los resultados presentados por los estudiantes en las Olimpiadas promovidas en la escuela y por la OBA (Olimpiada Brasilera de Astronomía) permitieron verificar un creciente aprendizaje y estimulo hacia las materias científicas, comprobados por la apropiada expresión de los conceptos adquiridos de astronomía y presentados en evaluaciones o en informes obtenidos de ellos mismos, sus familias y profesores. Desenvolvendo um trabalho voluntário junto aos alunos do ensino fundamental no 1º ciclo (1ª a 4ª série), os monitores de Astronomia membros do CAIMP (Clube de Astronomia de Itaocara Marcos Pontes), que eram em sua maioria alunos do ensino médio, desenvolveram um trabalho de aproximação entre os alunos do Colégio Estadual Teotônio Brandão Vilela e os temas envolvendo Ciências e Astronomia. Através de oficinas de informática, artes, vídeos educativos e teatros de fantoches, os alunos puderam expressar seus conhecimentos e emoções diante das lendas mitológicas com as quais começaram a ter contato. O trabalho desenvolvido pelos monitores junto aos alunos proporcionou a integração entre as turmas do colégio e os levou a participação em atividades de maneira a estimular sua oralidade e aumentar sua auto-estima. Trabalhando várias formas de expressões, os alunos puderam realizar seus experimentos e conhecer alguns conceitos de Física e Astronomia, enquanto adquiriam autonomia para se expressarem de acordo com seus sentimentos e conhecimentos adquiridos. O trabalho em si mostrou além da possibilidade de inserção de Astronomia no Ensino Fundamental, a possibilidade de realização de um trabalho interdisciplinar nas séries iniciais envolvendo Astronomia, Arte e Mitologia. Os resultados apresentados

  20. Ensino de gravitação clássica no nível médio: uma proposta de abordagem e resultados preliminares

    NASA Astrophysics Data System (ADS)

    Medeiros, G. C. M.; Jafelice, L. C.

    2003-08-01

    O ensino de gravitação clássica é comumente realizado de maneira formal e descontextualizado da experiência com a força-peso e da história do tema. Fustigados por anos de experiência de ensino no assunto, nem sempre com bons resultados, propomos uma abordagem ancorada nos eixos: a) contextualização histórica; e b) reconhecimento do peso como a força de atração gravitacional. O primeiro eixo integra o tema no desenvolvimento cultural do ser humano, praticando a interdisciplinaridade. O segundo eixo embasa construtivamente a abordagem, levando o aluno a realizar experiências e a vivenciar o reconhecimento de uma força universal. A abordagem foi construída através das etapas: 1) análise crítica do tema em livros didáticos; 2) elaboração de um curso para professores das várias disciplinas do ensino médio, identificando conexões para a prática da interdisciplinaridade; 3) elaboração de material didático; e 4) avaliação da eficácia da abordagem. No trabalho discutimos em detalhe as quatro etapas. Como resultados, adiantamos que: tabulamos a abordagem de gravitação nos livros didáticos, ainda muito tradicional e carecedora de atividades criativas que poderiam melhor explorar esse assunto; mapeamos, junto aos professores, padrões de conceitos espontâneos e erros associados ao tema; e, no curso, adaptamos e testamos a eficiência de materiais instrucionais existentes e criamos outros novos (e.g., para trabalhar excentricidades das órbitas planetárias), além disto elaboramos roteiros e figuras para tratamentos qualitativo e quantitativo da lei da gravitação universal. As avaliações feitas pelos professores foram muito animadoras. O espaço da presente reunião será aproveitado para socializar a proposta e os resultados obtidos e para submeter o projeto à análise crítica. (PPGECNM/UFRN; PRONEX/FINEP; NUPA/USP; Temáticos/FAPESP)

  1. Creativity and Democratic Governance. Adult Learning: A Strategic Choice. Proceedings of the ICAE World Assembly (6th, Ocho Rios, Jamaica, August 9-12, 2001) = Creativite et Gouvernance Democratique. L'apprentissage des Adultes: Un Choix Strategique. Actes de la Assemblee Mondiale du CIEA (6th, Ocho Rios, Jamaique, 9 au 12 aout 2001) = Creatividad y Gobernabilidad Democratica. Educacion de Adultos: Una Eleccion Estrategica. Actas de la Asamblea Mundial del ICAE (6th, Ocho Rios, Jamaica, Agosto 9-12, 2001).

    ERIC Educational Resources Information Center

    Dobson, Stephan, Ed.

    This document contains information from and about a world assembly on creativity and democratic governance in adult learning that was held by the International Council for Adult Education (ICAE) and its partner organizations in the Caribbean. The proceedings begin with English, French, and Spanish translations of the address…

  2. Establishing the Empirical Relationship Between Non-Science Majoring Undergraduate Learners' Spatial Thinking Skills and Their Conceptual Astronomy Knowledge. (Spanish Title: Estableciendo Una Relación Empírica Entre el Razonamiento Espacial de los Estudiantes de Graduación de Carreras no Científicas y su Conocimento Conceptual de la Astronomía.) Estabelecendo Uma Relação Empírica Entre o RacioCínio Espacial dos Estudantes de Graduação EM Carreiras Não Científicas e Seu Conhecimento Conceitual da Astronomia

    NASA Astrophysics Data System (ADS)

    Heyer, Inge; Slater, Stephanie J.; Slater, Timothy F.

    2013-12-01

    normalizadas, en el desempeño de los estudiantes en estos dos asuntos foram pequenas, 0.26 e 0.13 respectivamente. El razonamiento espacial de los estudiantes fue medido utilizando un instrumento específico desarrollado para este trabaljo. Las correlaciones entre los resultados de los tests astronómicos y este instrumento específico, antes y después del curso mostraron una relación entre moderada y fuerte, sugiriendo que la relación entre el razonamiento espacial y el conocimiento astronómico puede explicar hasta un 25% de la variación em el desempeño de los estudiantes. A comunidade da educação em astronomia tem suposto de forma implícita que o aprendizado da astronomia consiste em um domínio conceitual fundamentado no raciocínio espacial. Como um primeiro passo para identificar formalmente uma relação empírica entre estas duas coisas, utilizamos como amostra os estudantes de graduação de carreiras não científicas de um curso exploratório em uma universidade norte-americana do meio-oeste de médio porte com programa de Doutorado em andamento, onde estes estudantes foram submetidos a um diagnóstico de raciocino espacial e conceitos astronômicos antes e depois do mesmo. As ferramentas utilizadas foram o Test Of Astronomy Standards (TOAST) e o questionário What do you know? Utilizando somente dados completamente consistentes para esta análise, nossa amostra consistiu de 86 estudantes de graduação. As melhoras, depois de normalizadas, do desempenho dos estudantes nos dois quesitos foram pequenas, 0.26 e 0.13 respectivamente. O raciocínio espacial dos estudantes foi medido utilizando um instrumento específico desenhado para este trabalho. As correlações entre os resultados dos testes astronômicos e este instrumento específico antes e depois do curso mostraram uma relação entre moderada e forte, sugerindo que a relação entre o raciocínio espacial e o conhecimento astronômico pode explicar até um 25% na variação no desempenho dos

  3. Apparent Motion of the Sun, Shadows of Objects and Measurement of Time in the View of Seventh Grade Students of Middle School. (Breton Title: Movimento Aparente do Sol, Sombras dos Objetos e Medição do Tempo na Visão de Alunos do Sétimo Ano do Ensino Fundamental.) Movimiento Aparente del Sol, Sombras de los Objetos y Medición del Tiempo en la Visión de Estudiantes del Séptimo Grado del Ciclo Pirmario

    NASA Astrophysics Data System (ADS)

    Iria Machado, Daniel

    2013-07-01

    analemático, conduzida por um monitor. Uma proporção significativa de estudantes desconhecia inicialmente a maioria dos fenômenos tratados. A intervenção realizada colaborou para uma parte dos alunos assimilar novos conceitos, propiciando o contato com novos fenômenos e, em menor grau, a elaboração de explicações a respeito destes, indicando um potencial educativo dessa ação. Porém, a contribuição para o entendimento de algumas das ideias exploradas foi pequena, apontando para a necessidade de se fazer observações, estudos e discussões complementares. El movimiento aparente del Sol en la esfera celeste y el comportamiento de las sombras de los objetos a lo largo del tiempo son fenómenos observables en la vida cotidiana. Sin embargo, los estudiantes a menudo no tienen una adecuada comprensión de dichos problemas, e incluso pueden mostrar conceptos erróneos acerca de ellos. Por lo tanto, se realizó una investigación a fin de conocer las nociones de los estudiantes acerca de estas cuestiones y evaluar la contribución a su comprensión proporcionada por una actividad realizada con un reloj de Sol interactivo, en un entorno informal de aprendizaje. Se investigaron las ideas de 43 estudiantes del séptimo grado del ciclo primario mediante la aplicación de un test con preguntas abiertas antes y después de una actividad con un reloj de Sol analemático, dirigida por un monitor. Una proporción significativa de los estudiantes inicialmente desconocía la mayoría de los fenómenos tratados. La intervención realizada contribuyó para que los estudiantes asimilasen nuevos conceptos, proporcionando el contacto con nuevos fenómenos y, en menor medida, desarrollasen explicaciones acerca de estos, lo que indica un potencial educativo de esta acción. Sin embargo, la contribución a la comprensión de algunas de las ideas exploradas fue pequeña, lo que apunta a la necesidad de hacer observaciones, estudios y debates adicionales.

  4. University Students' Conceptions about the Moon Phases. (Spanish Title: Concepciones de Estudiantes Universitários sobre Las Fases de la Luna.) Concepções de Estudantes Universitários sobre as Fases da Lua

    NASA Astrophysics Data System (ADS)

    de Fátima Oliveira Saraiva, Maria; da Silveira, Fernando Lang; Steffani, Maria Helena

    2011-07-01

    teste notamos que a porcentagem de acertos a respeito de alguns conceitos teve um aumento significativo associado à reformulação da pergunta, ressaltando a importância de tomar cuidado para evitar respostas erradas geradas por perguntas pouco claras e não por ignorância do respondente sobre o assunto. Confirmamos os resultados de outros estudos de que as maiores dificuldades dos alunos sobre o tema Fases da Lua dizem respeito a relacionar a fase que a Lua apresenta com a sua posição no céu em determinada hora. Por outro lado, nossos resultados sugerem que, em geral, os estudantes de Física entendem melhor o fenômeno das fases lunares do que a média dos estudantes universitários.

  5. Forms of Appropriation of Tools for the Astronomy Education in Continuous Training of Teachers. (Spanish Title: Formas de Apropriación de Herramientas Para la Enseñanza de la Astronomía en la Formación Docente Continua.) Formas de Apropriação de Instrumentos Para o Ensino de Astronomia na Formação Continuada de Professores

    NASA Astrophysics Data System (ADS)

    Marques Soares, Leonardo; Sousa Nascimento, Silvania

    2012-07-01

    siete relatos. O objetivo principal desse artigo é apresentar algumas reflexões sobre a maneira como um grupo de professores se apropriaram dos instrumentos do KIT PARA O ENSINO DE ASTRONOMIA (KITPEA). Os sujeitos dessa pesquisa participaram do curso de especialização em ensino de astronomia oferecido pelo Projeto de Formação Continuada (Foco) no Centro de Ensino de Ciências e Matemática (CECIMIG) da Faculdade de Educação da Universidade Federal de Minas Gerais (FaE/UFMG). Coletamos as informações por meio de um questionário e de uma entrevista, aplicados a esses professores. Estruturamos a análise dessas informações com a ajuda da Teoria da Atividade e da Teoria da Ação Mediada. Interpretamos as falas dos professores usando como dispositivo analítico os elementos constituintes do sistema de atividade e os conceitos de apropriação e domínio. Dentre os 11 sujeitos que participaram da pesquisa, foi possível identificar a apropriação dos instrumentos em 7 narrativas.

  6. A proposed contents astronomy for basic education

    NASA Astrophysics Data System (ADS)

    Albrecht, E.; Voelzke, M. R.

    2014-08-01

    quatro anos, nos quais, aparecem timidamente alguns conteúdos de Astronomia. Para o Ensino Médio, as propostas curriculares do Paraná e de Santa Catarina parecem que se repetem, apresentando apenas o conteúdo Gravitação Universal, na primeira série do Ensino Médio, já a proposta curricular do Rio Grande do Sul, traz uma sequência que é proposta nos PCN (Brasil, 1998; 1999; 2002), na qual aparece o tema em questão, porém, em todos os anos, em todas as propostas, não há um detalhamento do que, de como trabalhar os conteúdos. O detalhamento facilita a prática pedagógica, pois, conteúdos simples como as Estações do Ano, Fases da Lua, sequer são citados nas propostas curriculares pesquisadas. Outro aspecto observado é que os conteúdos de um modo geral não trazem uma sequência e não primam por partir do entorno do aluno, daquilo que ele conhece para estruturar novos conceitos. Tais aspectos dificultam o fazer pedagógico, pois, por ser uma região com características culturais semelhantes, era esperado que as propostas fossem mais próximas, o! que facilitaria em muito, por exemplo, transferências dentro de um mesmo estado ou interestaduais. Pautando-se no que foi observado, na falta de especificidade dos conteúdos, clareza, sequência dos conteúdos e propostas de trabalho é proposto uma sequência de conteúdos de Astronomia, com materiais e recursos, pois, como apontado por Langhi e Nardi (2009), é necessário fornecer além da informação, do conteúdo, o como fazer. Tal proposta não visa estabelecer-se como regra, mas como suporte ao professor para facilitar sua prática pedagógica e tornar o trabalho com Astronomia presente nas escolas brasileiras. Bardin, L. Análise de conteúdo. Tradução Luís Antero Reto, Augusto Pinheiro. São Paulo: Edições 70, 2011. 279 p. Langhi, R; Nardi, R. Ensino da astronomia no Brasil: educação formal, informal, não-formal e divulgação científica. Revista Brasileira de Ensino de Física, v. 31, n

  7. The controversy between Alexander Friedmann and Albert Einstein about the possibility of a non-static world (German Title: Die Kontroverse zwischen Alexander Friedmann und Albert Einstein um die Möglichkeit einer nichtstatischen Welt)

    NASA Astrophysics Data System (ADS)

    Singer, Georg

    Einstein's treatment of the cosmological problem as well as his unshakeable adherence to his own static solution of the complete field equations was throughout determined by Ernst Mach's idea of relativity of inertia. Friedmann, however, like Eddington, Weyl and others did not consider Mach's principle to be a part of general relativity, and so he regarded a time dependent developing spatial geometry as being consistent with world matter at relative rest. In his final statement to the controversy, Einstein acknowledged just formal correctness of Friedmann's results. Actually his criticism was not due ``to a miscalculation'', as he was ready to admit, but was owed to a fundamental fixed idea which continued to exist and which was the cause of his disavowal of physical significance of dynamical solutions.

  8. "Cos Um It like Put a Picture in My Mind of What I Should Write": An Exploration of How Home-School Partnership Might Support the Writing of Lower-Achieving Boys

    ERIC Educational Resources Information Center

    Scanlan, Mary

    2012-01-01

    This article outlines how home and school working together supported the writing of lower-achieving boys. It describes an activity in which parents and children selected artefacts at home to inspire writing in school. This model of home-school partnership permitted different levels of parental involvement and also allowed the child to take a key…

  9. O Imperio como Argumento: Um Contraponto entre Joaquim Nabuco e o Bispo D. Jose Mauricio da Rocha (The Empire as Argument: A Counterpoint between Joaquim Nabuco and the Bishop Dom Jose Mauricio da Rocha).

    ERIC Educational Resources Information Center

    Marson, Izabel Andrade

    1998-01-01

    Dialogs with the previous article establishing a comparative analysis between the political acceptance present in the reactionary speech of Dom Jose Mauricio da Rocha and in the monarchist words of Joaquim Nabuco. (PA)

  10. Michael Mästlin's role in the polemic against the calendar reform of pope Gregor XIII. (German Title: Die Rolle Michael Mästlins in der Polemik um die Kalenderreform von Papst Gregor XIII)

    NASA Astrophysics Data System (ADS)

    Hamel, Jürgen

    Because of theological resistance, the calendar reform of 1582 was introduced only in countries under catholic rule. Michael Mästlin is found among the spokesmen of opposition against this feared attempted of the pope to gain influence in the protestant church, nevertheless, Mästlin had no doubt that a calendar reform was necessary. This article retraces Mästlin's argumentation and puts it into context with contemporary discussions about a calendar reform.

  11. Percepção Astronômica de um Grupo de Alunos do Ensino Médio de uma Escola da Rede Estadual de São Paulo

    NASA Astrophysics Data System (ADS)

    de Oliveira, E. F.

    2007-06-01

    Being the Astronomy one of the oldest sciences of the humanity, and considering its historical and cultural importance, it is of extreme relevance that topics related to it are taught and studied at schools. Although the National Curriculum Parameters of the Senior High School (PCN-EM) and the Complementary Orientations to the Parameters (PCN+) indicate the importance of a significant approach of concepts related to the Astronomy in the Physics classes, many students finish the Senior High School (EM) without understanding the reason of certain events of celestial origin, although these are part of their daily lives and are a subject of natural curiosity for the youngsters. From the perception of the natural curiosity of the students of a São Paulo's Public School in the city of Suzano, came up the interest to investigate the basic knowledge in Astronomy of the Senior High School students at this school, becoming this the main goal of this research. A questionnaire of multiple choices was elaborated and initially applied to 34 students of the first grade and later, to more 310 students. It was distributed among the three grades of the Senior High School in the morning and night periods. In the way, it was observed that 73.9% of the students identified the Sun as a star, 67.1% demonstrated to understand the succession between the day and the night and 52.3% related the Big Bang to the origin of the Universe. In compensation, only 34.5% related the seasons of the year to the inclination of the rotation axis of the Earth, 21.3% indicated the simultaneous gravitational influence of the Moon and the Sun as responsible for the tides phenomenon, 24.5% correctly indicated which are the closest celestial objects to the Earth, 36.1% identified the light-year as a distance measure and only 34.2% recognized the shooting stars as meteors, being evidenced the small discernment of the students about the phenomena and astronomical terms of the daily life. Besides, the answers of different grade students and periods were compared, being observed, among other things, that the third grade students present a percentile of correct answers similar to the performance of the first grade students, demonstrating that the approach of topics related to the astronomy in the Senior High School has not been contributing in a significant way to a better understanding of the phenomena and the concepts.

  12. Uncooled 10μm FPA development at DRS

    NASA Astrophysics Data System (ADS)

    Skidmore, George D.

    2016-05-01

    The benefit of 10um pitch uncooled detectors is demonstrated through the use of image emulation. The image emulation uses the theoretical image of point sources for 10um wavelength radiation, then integrates the energy from multiple sources which fall into FPA pixel areas and produces representative images. Arrays of pixel pitches of 25um, 17um, 12um, 10um, 5um, and 4um are included. These images, and movies when presented live at the conference, make evident why array pitches smaller than the wavelength of radiation are useful and being considered. While the argument for sub-wavelength pixel pitches is already made by other authors, this representation might be clearer to a larger audience. Representative images, and movies when presented live at the conference, from a DRS 1280x1024 format, 10um pitch array are shown. Details of the DRS 10um pitch UFPA family are shown.

  13. Adherence to a Physical Activity Program by Older Adults in Brazil

    ERIC Educational Resources Information Center

    de Souza, Doralice Lange; Vendruscolo, Rosecler

    2010-01-01

    This paper discusses the results of a qualitative research project in which we investigated adherence factors to a physical activity (PA) program for older adults in Brazil named "Sem Fronteiras: Atividades Corporais Para Adultos Maduros e Idosos", which translated into English means "Without Borders: Physical Activities for Mature and Older…

  14. Cuidados médicos de apoyo en niños (PDQ®)—Versión para profesionales de salud

    Cancer.gov

    Resumen de información revisada por expertos acerca de la peculiaridad de los asuntos que surgen durante y después del tratamiento en los niños con cáncer y como sobrevivientes adultos de cáncer.

  15. Estudio del NCI revela que la obesidad extrema puede acortar la esperanza de vida hasta en 14 años

    Cancer.gov

    Los adultos con obesidad extrema tienen mayor riesgo de morir a edad más joven por cáncer y muchas otras causas entre ellas, enfermedades cardíacas, accidentes cerebrovasculares, diabetes y enfermedades del hígado y los riñones, según estudio del NCI.

  16. Optimal Short Forms of the Spanish WAIS (EIWA).

    ERIC Educational Resources Information Center

    Demsky, Yvonne; Gass, Carlton; Edwards, William T.; Golden, Charles J.

    1998-01-01

    Investigated optimal two-, three-, four-, and five-test short forms of the Escala de Inteligencia Wechsler para Adultos (EIWA), the Spanish form of the Wechsler Adult Intelligence Scale (D. Wechsler, 1956). Results with 616 adults suggest that use of the EIWA should be limited to research and tracking cognitive changes over time. (SLD)

  17. Estudio de los Institutos Nacionales de la Salud indica que quienes toman café tienen un riesgo meno

    Cancer.gov

    Los adultos mayores que tomaron café, con o sin cafeína, tuvieron un riesgo menor de muerte en general que quienes no tomaron café, según un estudio llevado a cabo por investigadores del Instituto Nacional del Cáncer (NCI), parte de los Institutos Naciona

  18. Para muchos jóvenes supervivientes de cáncer, los efectos tardíos representan problemas duraderos

    Cancer.gov

    Artículo sobre los efectos tardíos en la salud que afectan a ciertos adolescentes y adultos jóvenes supervivientes de cáncer, y la necesidad de aumentar la concientización y la vigilancia de estos efectos tardíos.

  19. Literacy for Citizenship: Gender and Grassroots Dynamics in Brazil. SUNY Series, Literacy, Culture, and Learning.

    ERIC Educational Resources Information Center

    Stromquist, Nelly P.

    This book presents a case study of the MOVA (Movimento de Alfabetizacao de Jovens e Adultos) literacy program in Sao Paulo, Brazil, in 1989-1993. It examines the meaning and uses of literacy at the micro- and macro-levels, the interplay between both levels, and forces influencing educational policy formation and outcome. The foreword provides…

  20. Cuidados médicos de apoyo en niños (PDQ®)—Versión para pacientes

    Cancer.gov

    Resumen de información revisada por expertos acerca de la peculiaridad de los asuntos que surgen durante y después del tratamiento en los niños con cáncer, y como sobrevivientes adultos de cáncer.

  1. MOBRAL--The Brazilian Adult Literacy Experiment. Educational Studies and Documents No. 15.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France).

    The Brazilian Literacy Movement (MOBRAL-El Movimento Brasileno de Alfabetizacion de Adultos) is discussed in terms of its legal and conceptual bases, organization, participants, technical aspects, and effectiveness. Established by law December 15, 1967 to lower the illiteracy rate in Brazil by improving educational opportunities for the…

  2. New Paradigms for Adult Learning: Building on Mexican Immigrants' Prior Experience To Develop Basic Skills for the Information Society.

    ERIC Educational Resources Information Center

    Kissam, Edward

    This paper examines basic skills competencies developed by Mexican immigrant adult learners through participation in (although not always completion of) adult basic education programs conducted by the Mexican, Instituto Nacional para la Educacion de los Adultos (INEA). The comparison provides the conceptual basis for configuring instructional…

  3. Estudio de NIH señala relación de la TC en la infancia con leucemia y cáncer de cerebro más tarde

    Cancer.gov

    Niños y adultos jóvenes a quienes se les hicieron exploraciones muchas veces con tomografía computarizada (TC), una herramienta de diagnóstico de uso frecuente, tienen un riesgo ligeramente mayor de padecer leucemia y tumores cerebrales en la década poste

  4. Determining the Shape of the Orbit of Mars in the High School. (Spanish Title: Determinación de la Forma de la Órbita de Marte en la Escuela Secundaria.) Determinando a Forma da Órbita de Marte no Ensino Médio

    NASA Astrophysics Data System (ADS)

    Dutra, Carlos Maximiliano; Rossini Goulart, Andressa

    2014-12-01

    In the present work, in order to supply the lacks of practical activities related to the content of Kepler's Laws in high school physics textbooks, we present a practical activity to determine the shape of the orbit of Mars. In this activity the student can experience the discovery the shape of the orbit of Mars in a way similar to that realized by Johannes Kepler combining the physical concepts with geometry. We applied the activity to eighteen high school teachers participating in a Postgraduate Course in Science Education. After two hours of work the group obtained the shape of the orbit of Mars and estimated its orbital parameters with a relative error less than 14%. En el presente trabajo y con el objetivo de reducir la escasez de actividades prácticas relacionadas con el contenido de las leyes de Kepler en libros de texto de física de la escuela secundaria, se presenta una actividad práctica para determinar la forma de la órbita de Marte. En esta actividad el estudiante puede vivir la experiencia de descubrir la forma de la órbita de Marte de una manera similar a la realizada por Johannes Kepler combinando los conceptos físicos con la geometría. Aplicamos la actividad a dieciocho maestros de escuelas secundarias en un Curso de Especialización en Enseñanza de las Ciencias. Después de dos horas de trabajo el grupo obtuvo la forma de la órbita de Marte com error inferior al 14% en los parámetros orbitales. No presente trabalho, visando suprir a deficiência de atividades práticas relacionadas ao conteúdo de Leis de Kepler nos livros-textos de Física do 1º ano do Ensino Médio, apresentamos uma atividade prática de determinação da órbita de Marte. O aluno, combinando conceitos físicos com a geometria poderá vivenciar a experiência da descoberta da forma da órbita de Marte de modo similar ao realizado por Johannes Kepler. Aplicamos a metodologia proposta junto a dezoito professores do Curso de Especialização em Educação em Ciências e

  5. Reviving Erathostenes. (Breton Title: Revivendo Eratóstenes.) Reviviendo a Eratóstenes.

    NASA Astrophysics Data System (ADS)

    Pereira, Paulo Cesar R.

    2006-12-01

    As part of the commemorations of the International Year of the Physics and having as its main objective to introduce students to the scientific method, the Rio de Janeiro Planetarium Foundation, in partnership with many institutions of Brazil and Europe, coordinated the activity "Reviving Eratosthenes" whose objective was the determination of the Earth's circumference. We used the famous procedure adopted by Eratosthenes more than 2000 years ago, with some adaptations. This work considers and analyzes the method used by us, aiming the application in schools. The use of places in different meridians allows a better understanding of the abstract concepts such as geographic coordinate and time zones. We obtained reasonably precise results, which improve for pairs of distant cities. Finally, one of the most important conclusions achieved by the students involved is the importance of the cooperation (international in this case) to solve problems. Fazendo parte das comemorações do Ano Internacional da Física e tendo como principal objetivo introduzir estudantes do ensino médio ao método científico, a Fundação Planetário da Cidade do Rio de Janeiro, em parceria com diversas instituições do Brasil e da Europa, coordenou a atividade "Revivendo Eratóstenes" cujo objetivo foi a determinação da circunferência da Terra. Para isso, utilizou-se um procedimento semelhante ao empregado pelo sábio Eratóstenes há mais de 2.000 anos, com algumas adaptações. Este trabalho propõe e analisa o método que empregamos, visando a aplicação em escolas. A possibilidade de se trabalhar com locais em diferentes meridianos permite uma melhor compreensão dos conceitos mas abstratos, como coordenadas e fusos horários. A precisão dos resultados é bastante razoável, melhorando para cidades bem afastadas. Finalmente, uma das conclusões mais importantes é a percepção, por parte dos estudantes, da importância da colaboração (neste caso, internacional) para resolver

  6. Astronomy, Art and Mythology in a Public Elementary School in Itaocara/rj. (Spanish Title: Astronomía, Arte y Mitologia en el Ensino Fundamental en Una Escuela de la Red Estatal en ITAOCARA/RJ.) Astronomia, Arte e Mitologia no Ensino Fundamental em Escola da Rede Estadual em ITAOCARA/RJ

    NASA Astrophysics Data System (ADS)

    Oliveira Bernardes, Adriana; Ramos dos Santos, Arleidimar

    2008-12-01

    conocimientos recibidos. El trabajo en sí ha mostrado además de la posibilidad de la inclusión de la Astronomía en la Educación Primaria, la posibilidad de un trabajo interdisciplinario en los niveles iniciales incluyendo Astronomía, Arte y Mitología. Los resultados presentados por los estudiantes en las Olimpiadas promovidas en la escuela y por la OBA (Olimpiada Brasilera de Astronomía) permitieron verificar un creciente aprendizaje y estimulo hacia las materias científicas, comprobados por la apropiada expresión de los conceptos adquiridos de astronomía y presentados en evaluaciones o en informes obtenidos de ellos mismos, sus familias y profesores. Desenvolvendo um trabalho voluntário junto aos alunos do ensino fundamental no 1º ciclo (1ª a 4ª série), os monitores de Astronomia membros do CAIMP (Clube de Astronomia de Itaocara Marcos Pontes), que eram em sua maioria alunos do ensino médio, desenvolveram um trabalho de aproximação entre os alunos do Colégio Estadual Teotônio Brandão Vilela e os temas envolvendo Ciências e Astronomia. Através de oficinas de informática, artes, vídeos educativos e teatros de fantoches, os alunos puderam expressar seus conhecimentos e emoções diante das lendas mitológicas com as quais começaram a ter contato. O trabalho desenvolvido pelos monitores junto aos alunos proporcionou a integração entre as turmas do colégio e os levou a participação em atividades de maneira a estimular sua oralidade e aumentar sua auto-estima. Trabalhando várias formas de expressões, os alunos puderam realizar seus experimentos e conhecer alguns conceitos de Física e Astronomia, enquanto adquiriam autonomia para se expressarem de acordo com seus sentimentos e conhecimentos adquiridos. O trabalho em si mostrou além da possibilidade de inserção de Astronomia no Ensino Fundamental, a possibilidade de realização de um trabalho interdisciplinar nas séries iniciais envolvendo Astronomia, Arte e Mitologia. Os resultados apresentados

  7. Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma

    PubMed Central

    Rodrigues, Murilo; Deshpande, Monika; Puchner, Brooks; Kashiwabuchi, Fabiana; Hassan, Syed Junaid; Asnaghi, Laura; Handa, James T.; Merbs, Shannath; Eberhart, Charles G.; Semenza, Gregg L.; Montaner, Silvia; Sodhi, Akrit

    2016-01-01

    Purpose Expression of the hypoxia-inducible factor (HIF)-1-regulated gene product, vascular endothelial growth factor (VEGF), correlates with tumor vascularity in patients with uveal melanoma (UM). While the relationship between HIF-1 and VEGF in cancer is well-studied, their relative contribution to the angiogenic phenotype in UM has not previously been interrogated. Here we evaluate the contribution of HIF-1, VEGF, and a second HIF-1-regulated gene product, angiopoietin-like 4 (ANGPTL4), to angiogenesis in UM. Experimental Design UM cells were examined for expression of HIF-1α, VEGF, and ANGPTL4. Their contribution to the angiogenic potential of UM cells was assessed using the endothelial cell tubule formation and directed in vivo angiogenesis assays. These results were corroborated in tissue from UM animal models and in tissue from patients with UM. Results Inhibition of VEGF partially reduced tubule formation promoted by conditioned medium from UM cells. Inhibition of ANGPTL4, which was highly expressed in hypoxic UM cells, a UM orthotopic transplant model, a UM tumor array, and vitreous samples from UM patients, inhibited the angiogenic potential of UM cells in vitro and in vivo; this effect was additive to VEGF inhibition. Conclusions Targeting both ANGPTL4 and VEGF may be required for the effective inhibition of angiogenesis in UM. PMID:26761211

  8. Focused Cardiac Ultrasound Using a Pocket-Size Device in the Emergency Room.

    PubMed

    Mancuso, Frederico José Neves; Siqueira, Vicente Nicoliello; Moisés, Valdir Ambrósio; Gois, Aécio Flavio Teixeira; Paola, Angelo Amato Vincenzo de; Carvalho, Antonio Carlos Camargo; Campos, Orlando

    2014-10-28

    direcionada como complemento diagnóstico ao exame físico em um serviço terciário de emergências clínicas. Métodos: Foram incluídos cem pacientes adultos sem doenças cardíacas ou pulmonares conhecidas que procuraram atendimento de urgência com queixas cardiológicas. Foram excluídos pacientes com alterações isquêmicas no eletrocardiograma ou febre. A ecocardiografia direcionada foi realizada logo após a avaliação inicial do paciente na sala de emergência, com aparelho ultraportátil GE Vscan, avaliando subjetivamente: dimensões das cavidades, função sistólica ventricular, fluxos intracardíacos pelo mapeamento de fluxo em cores, pericárdio e aorta. Resultados: A idade média dos pacientes foi 61 ± 17 anos. O quadro clínico inicial foi dor torácica (52 pacientes), dispneia (32 pacientes), arritmia/avaliação da função ventricular (dez pacientes), hipotensão/tontura (cinco pacientes) e edema periférico (um paciente). Em 28 pacientes a ecocardiografia direcionada confirmou a hipótese diagnóstica inicial: 19 pacientes com insuficiência cardíaca, cinco com síndrome coronariana aguda, dois com tromboembolismo pulmonar e dois com tamponamento cardíaco. Em 17 pacientes, a ecocardiografia direcionada alterou o diagnóstico, afastando a hipótese clínica inicial em dez casos com suspeita de insuficiência cardíaca, dois com suspeita de tromboembolismo pulmonar, dois com hipotensão a esclarecer, e em cada um dos três restantes com suspeitas de síndrome coronariana aguda, tamponamento cardíaco e dissecção de aorta. Conclusão: A ecocardiografia direcionada ultraportátil em serviço de emergências clínicas pode definir rapidamente o diagnóstico e, com isso, é possível iniciar mais precocemente o tratamento adequado. PMID:25352461

  9. Isolation and characterization of genetic variability in bacteria with β-hemolytic and antifungal activity isolated from the rhizosphere of Medicago truncatula plants.

    PubMed

    Hernández-Salmerón, J E; Prieto-Barajas, C M; Valencia-Cantero, E; Moreno-Hagelsieb, G; Santoyo, G

    2014-01-01

    In the present study, we analyzed the frequency of hemolytic and antifungal activities in bacterial isolates from the rhizosphere of Medicago truncatula plants. Of the 2000 bacterial colonies, 96 showed β-hemolytic activities (frequency, 4.8 x 10(-2)). Hemolytic isolates were analyzed for their genetic diversity by using random amplification of polymorphic DNA, yielding 88 haplotypes. The similarity coefficient of Nei and Li showed a polymorphic diversity ranging from 0.3 to 1. Additionally, 8 of the hemolytic isolates showed antifungal activity toward plant pathogens, Diaporthe phaseolorum, Colletotrichum acutatum, Rhizoctonia solani, and Fusarium oxysporum. The 16S ribosomal sequencing analysis showed that antagonistic bacterial isolates corresponded to Bacillus subtilis (UM15, UM33, UM42, UM49, UM52, and UM91), Bacillus pumilus (UM24), and Bacillus licheniformis (UM88). The present results revealed a higher genetic diversity among hemolytic isolates compared to that of isolates with antifungal action. PMID:25062484

  10. VizieR Online Data Catalog: IAS Stacking Library in IDL (Bethermin+, 2010)

    NASA Astrophysics Data System (ADS)

    Bethermin, M.; Dole, H.; Beelen, A.; Aussel, H.

    2010-04-01

    Number counts reach 35uJy, 3.5mJy and 40mJy at 24um, 70um, and 160um, respectively. We reach deeper flux densities of 0.38mJy at 70, and 3.1 at 160um with a stacking analysis. Products (point spread function, counts, CIB, contributions, software) are publicly available for download at http://www.ias.u-psud.fr/irgalaxies/ (2 data files).

  11. PubMed

    Barrantes-Monge, Melba; Rodríguez, Eduardo; Lama, Alexis

    2009-01-01

    Existen prejuicios en relación con la vejez, incluso entre los profesionales que se dedican a la gerontología. Uno común y peligroso es considerar que los viejos son todos enfermos o discapacitados.La relación médico-paciente es la piedra angular de la práctica y ética médicas. Para alcanzar el respeto por los adultos mayores es necesaria una medicina prudente, basada en una práctica en la cual la reflexión ética y clínica pueda contribuir. Esto último es posible si se hacen valer los derechos del adulto mayor, en particular como paciente para la toma de decisiones. PMID:20379380

  12. Assessment of Teams and Teamwork in the University of Maryland Libraries

    ERIC Educational Resources Information Center

    Baughman, M. Sue

    2008-01-01

    Teams play an important role in the University of Maryland (UM) Libraries. Since 1998, teams and collaborative teamwork have become the way librarians address the myriad of issues affecting the needs of UM's faculty, students, and staff. There has been much change in the UM Libraries over the past nine years, and the development is ongoing.…

  13. REDUCTIVE DEHALOGENATION OF HEXACHLOROETHANE, CARBON TETRACHLORIDE, AND BROMOFORM BY ANAHYDROQUINONE DISULFONATE AND HUMIC ACID

    EPA Science Inventory

    The reductive dehalogenation of hexachloroethane (C2CI6), carbon tetrachloride (CC14), and bromoform (CHBr3) was examined at 50 degrees C in aqueous solutions containing either (1) 500 uM of 2,6-anthrahydroquinone disulfonate (AHQDS), (2) 250 uM Fe2+, or (3) 250 uM HS. The pH ran...

  14. Portal Monitor Future Development Work: Hardware Improvements

    SciTech Connect

    Browne, Michael C.

    2012-07-03

    LANL portal monitor was a modification of a previously installed (permanent) unattended monitoring system (UMS). Modifications to the UMS to make the portal were sometimes based on mistaken assumptions about exercise-specific installation and access. Philosophical approach to real-time portal differs in some areas from UMS.

  15. Utopia Middle School

    ERIC Educational Resources Information Center

    Cloud, Michelle

    2006-01-01

    The following excerpt allows the reader to briefly peer into an ideal school setting: For the purposes of this paper, the fictitious school will be named Utopia Middle School or U.M.S. U.M.S embodies and exemplifies the perfect school. At U.M.S., the campus administrators perform at a level of excellence that motivates, empowers and supports all…

  16. Clinical Outcomes in Patients with Intermediate Coronary Stenoses: MINIATURE Investigators (Korea MultIceNter TrIal on Long-Term Clinical Outcome According to the Plaque Burden and Treatment Strategy in Lesions with MinimUm Lumen ARea lEss Than 4 mm2 Using Intravascular Ultrasound)

    PubMed Central

    Hong, Young Joon; Choi, Yun Ha; Park, Soo Young; Nam, Chang Wook; Cho, Jang Hyun; Kang, Won Yu; Lee, Sang Rok; Lee, Sung Yun; Kim, Sang Wook; Lim, Sang Yeob; Yun, Kyung Ho; Kim, Jung Sun; Kim, Jin Won; Kang, Woong Chol; Kim, Ki Seok; Choi, Jin Ho; Chung, Joong Wha; Kim, Soo Joong; Ahn, Youngkeun

    2014-01-01

    Background and Objectives We evaluated the two-year clinical outcomes in patients with angiographically intermediate lesions according to the plaque burden and treatment strategy. Subjects and Methods We prospectively enrolled patients with angiographically intermediate lesions (diameter stenosis 30-70%) with an intravascular ultrasound (IVUS) minimum lumen area (MLA) <4 mm2 with 50-70% plaque burden of 16 Korean percutaneous coronary intervention centers. Patients were divided into medical therapy group (n=85) and zotarolimus-eluting stent group (ZES; Resolute) group (n=74). We evaluated the incidences of two-year major adverse cardiovascular events (MACE). Results A two-year clinical follow-up was completed in 143 patients and MACE occurred in 12 patients. There were no significant differences in the incidences of death (1.3% vs. 3.0%, p=0.471), target vessel-related non-fatal myocardial infarction (0.0% vs. 0.0%, p=1.000) and target vessel revascularizations (7.8% vs. 4.5%, p=0.425) between medical and ZES groups. Independent predictors of two-year MACE included acute myocardial infarction {odds ratio (OR)=2.87; 95% confidence interval (CI) 1.43-6.12, p=0.014}, diabetes mellitus (OR=2.46; 95% CI 1.24-5.56, p=0.028) and non-statin therapy (OR=2.32; 95% CI 1.18-5.24, p=0.034). Conclusion Medical therapy shows comparable results with ZES, and myocardial infarction, diabetes mellitus and non-statin therapy were associated with the occurrence of two-year MACE in patients with intermediate lesion with IVUS MLA <4 mm2 with 50-70% of plaque burden. PMID:24876855

  17. "Was für Grün in der Stadt?". Politische Aushandlungsprozesse um städtische Grün- und Freiräume am Beispiel des urbanen Gärtnerns in Schweizer Städten

    NASA Astrophysics Data System (ADS)

    Klöti, Tanja; Tappert, Simone; Drilling, Matthias

    2016-06-01

    Urban green space is a key subject of actual urban negotiation processes on how the city shall develop. Visions of the ideal city are reflected in the meanings currently ascribed to urban gardening. Thereby the relation between human and nature as well as between build and natural environment in the city plays a central role. Results from different Swiss cities show that allotment gardens as well as newer forms of urban gardening are oscillating between a compensatory and a complementary understanding of nature, and they equally combine the desire for pristine nature with the demand for functional green space in the city.

  18. Resolving the Youngest Episode of Zircon Rim Growth with High-Spatial Resolution SIMS: U-Pb Ages and Trace Element Analyses from <1 um Thick Metamorphic Zircon Rims from the Zanskar Shear Zone and Tso Morari UHP Complex, NW Himalaya

    NASA Astrophysics Data System (ADS)

    Coble, M. A.; Leech, M. L.

    2014-12-01

    Dating the youngest phase of metamorphic or magmatic zircon growth by in-situ techniques on sectioned zircons can be challenging when rims are only a few microns thick; in the worst case, geologically meaningless measurements result from mixing between different age and/or compositional growth domains. This is especially true for zircons from the Zanskar Shear Zone and Tso Morari UHP Complex, NW Himalaya, which contain Eocene to Miocene rims that grew over Paleozoic and Proterozoic protolith cores during peak and retrograde metamorphism. These metamorphic rims are typically only 0.5 to 3.0 microns thick and require high-spatial resolution to resolve. We used the SHRIMP-RG ion-microprobe to perform new U-Pb depth-profiling analyses on zircon surfaces (non-polished) pressed into indium metal. Zircons from a leucogranite dike from Malung Tokpo along the Zanskar Shear Zone, which have 2000-5000 ppm U rims, were selected for detailed depth-profiling to evaluate the depth-resolution by SIMS for U-Pb and trace element analyses. Due to the high U concentration, we were able to decrease the primary beam intensity (sputter rate) and the count times for U and Pb isotopes, and increase the number of cycles through the run-table (45 peak-hopping scans). As a result, each cycle yielded a 0.04 micron depth-resolved zircon age and trace element composition. The youngest 13 scans yielded a U-Pb age of 21.3 ± 0.5 Ma, representing a 0.6 micron rim with uniform U, Th, and Hf concentrations. At 1.15 microns, the primary beam sputtered into a ~600 Ma core; this older age is complicated by the fact that it reflects mixing between the bottom of the sputter volume and the Miocene ages of the pit margins and rim, because the diameter of the spot tends to increase with time. Trace element analyses on zircon surfaces from the Tso Morari UHP Complex are highly reproducible, showing enriched HREE profiles with negative Eu anomalies - a result that is difficult to reproduce by analyses of sectioned crystals.

  19. "Was für Grün in der Stadt?" - Politische Aushandlungsprozesse um städtische Grün- und Freiräume am Beispiel des urbanen Gärtnerns in Schweizer Städten

    NASA Astrophysics Data System (ADS)

    Klöti, Tanja; Tappert, Simone; Drilling, Matthias

    2016-06-01

    Urban green space is a key subject of actual urban negotiation processes on how the city shall develop. Visions of the ideal city are reflected in the meanings currently ascribed to urban gardening. Thereby the relation between human and nature as well as between build and natural environment in the city plays a central role. Results from different Swiss cities show that allotment gardens as well as newer forms of urban gardening are oscillating between a compensatory and a complementary understanding of nature, and they equally combine the desire for pristine nature with the demand for functional green space in the city.

  20. VizieR Online Data Catalog: Perseus dust optical depth and column density maps (Zari+, 2016)

    NASA Astrophysics Data System (ADS)

    Zari, E.; Lombardi, M.; Alves, J.; Lada, C.; Bouy, H.

    2015-11-01

    We present optical depth and temperature maps of the Perseus Molecular Cloud, created combining Planck and Herschel data. The maps were obtained using Herschel SPIRE 250um, SPIRE 350um, SPIRE 500um, and, where available, PACS 160um data. The file planckherschelfit.fits reports the results of a full SED fit (with free parameters the optical depth and the temperature), at the SPIRE 500um resolution (36-arcsec). The file planckherschelfit2-a.fits uses the temperature from planckherschelfit.fits and the flux at SPIRE 250um to infer the optical depth with a resolution of 18 arcsec. Finally, the catalogue of Class I/0 protostars reports WISE magnitudes for the sources used to estimate the Schmidt law. (3 data files).

  1. VizieR Online Data Catalog: Spitzer/IRS debris disk catalog. I. (Chen+, 2014)

    NASA Astrophysics Data System (ADS)

    Chen, C. H.; Mittal, T.; Kuchner, M.; Forrest, W. J.; Lisse, C. M.; Manoj, P.; Sargent, B. A.; Watson, D. M.

    2014-05-01

    In Chen et al. (2006ApJS..166..351C), we obtained IRS spectra of 59 main-sequence stars with previously reported IRAS 60um excesses. We augment those data with newly obtained IRS spectra of 64 main-sequence stars with MIPS 24um and/or IRAS 25um excesses using the SL (5.2-14.0um) and LL (14.0-38.0um; λ/Δλ~60) modules as part of the program "Characterizing Warm Debris around Main Sequence Stars" (PID 40651 led by PI: J. Houck). For targets not observed as part of our programs, we downloaded Cornell Atlas of Spitzer/Infrared Spectrograph Sources (CASSIS; Lebouteiller et al. 2011ApJS..196....8L) spectra wherever possible. We assembled MIPS 24 and/or 70um photometry for 473 IRS sources to calibrate the IRS spectra and better constrain our targets' global SEDs (see Table 2). (4 data files).

  2. Resonances and Tides in Natural Satellites Systems. (Breton Title: Ressonâncias e Marés em Sistemas de Satélites Naturais.) Resonancias y Mareas en Sistemas de Satélites Naturales

    NASA Astrophysics Data System (ADS)

    Callegari, Nelson, Jr.

    2006-12-01

    In this work we describe some aspects of the dynamics of the mean-motion resonances. Emphasis to the case of resonances between regular satellites of the giant planets will be given, even so some aspects of the physics of the resonances in extra-solar planetary systems are also briefly treated. The role of the resonances in satellites systems is discussed through examples, showing how certain resonances, and its relations with the tidal dissipation effects, can be the key of the explanation of some phenomena still not explained in the Solar System. Amongst some examples we highlight the problem of the resurfacing of Enceladus, the existence of active volcanoes in Io, and the possible existence of the subsurface ocean in Europe. This work has as objective the divulgation of some topics in Celestial Mechanics and Planetary Sciences for an undergraduate public in exact sciences, as Astronomy and Physics, and not their detailed description. Neste trabalho descrevemos alguns aspectos da dinâmica de ressonâncias de movimentos médios. Será dada ênfase maior ao caso de ressonâncias entre satélites regulares dos planetas gigantes, embora alguns aspectos da física das ressonâncias em sistemas planetários extra-solares também sejam discutidos brevemente. A importância do estudo de ressonâncias em sistemas de satélites é discutida mais detalhadamente através de exemplos, mostrando como certas ressonâncias e suas relações com efeitos de dissipação de maré podem ser a chave de parte da explicação de alguns fenômenos ainda não explicados no Sistema Solar. Dentre vários exemplos destacamos o problema da remodelagem da superfície do satélite Enceladus, a existência de vulcões ativos em Io, e a possível existência do oceano subterrâneo em Europa. Este trabalho tem como objetivo a divulgação de alguns tópicos de Mecânica Celeste e Planetologia para um público de nível de graduação em disciplinas na área de exatas, em especial Astronomia e F

  3. VizieR Online Data Catalog: NIR sources in the northeastern part of LMC (Kim+, 2016)

    NASA Astrophysics Data System (ADS)

    Kim, J.; Jeong, W.-S.; Pak, S.; Park, W.-K.; Tamura, M.

    2016-02-01

    We observed the northeastern regions of the LMC using the infrared camera SIRIUS and the polarimeter SIRPOL at the Infrared Survey Facility (IRSF) 1.4m telescope at the South African Astronomical Observatory (SAAO) on 2008 December 25-30 and 2011 December 2-11; in the J (1.25um), H (1.63um), and Ks (2.14um) bands. (1 data file).

  4. VizieR Online Data Catalog: DR 21 Chandra source catalogue (Rivilla+, 2014)

    NASA Astrophysics Data System (ADS)

    Rivilla, V. M.; Jimenez-Serra, I.; Martin-Pintado, J.; Sanz-Forcada, J.

    2014-11-01

    In our analysis, we used archival stellar catalogues in X-rays, optical and IR wavelengths. We also made use of the Spitzer 4.6um and 8um images (Cygnus-X Legacy Project), and the Submillimetre Common-User Bolometer Array (SCUBA) 850um data (Matthews et al. 2009ApJS..182..143M, Cat. J/ApJS/182/143). (1 data file).

  5. Utilization management for residential programs.

    PubMed

    Kidd, Sean A; Styron, Thomas H; Carlson, Shelly; Hoge, Michael

    2004-07-01

    This paper reviews recent literature on utilization management (UM) in community-based supportive residential programs for people with behavioral disorders. Various approaches for facilitating placement and movement are discussed in the context of an effort to develop a residential UM process in New Haven, Connecticut. Recommendations are made for a residential UM process that may be applied to a range of service systems. It takes into account the methodological difficulties inherent in the development of generalizable decision tools. PMID:15478874

  6. Rhizotoxic effects of silver in cowpea seedlings

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Silver (Ag) is highly toxic to aquatic organisms, including algae, invertebrate animals and fish, but there is little information on Ag rhizotoxicity in higher plants. In two solution culture experiments with ca. 1000 uM Ca(NO3)2 and 5 uM H3BO3 (pH 5.4), 20 to 37 % of added Ag (= 2 uM) was lost fro...

  7. Somatic embryogenesis in immature cotyledons of Manchurian ash (Fraxinus mandshurica Rupr.)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Somatic embryogenesis was obtained from immature cotyledon explants that were cultured on half-strength Murashige and Skoog (MS) salts and vitamins with 5.4 uM naphthaleneacetic acid (NAA) and 0.2 uM thidiazuron (TDZ) plus a 4x4 factorial combination of 0,9.8, 34.6, or 49.2 uM indole-3-butyric acid ...

  8. Using optical coherence tomography to assess the role of age and region in corneal epithelium and palisades of vogt

    PubMed Central

    Lin, Hsuan-Chieh; Tew, Teck Boon; Hsieh, Yi-Ting; Lin, Szu-Yuan; Chang, Huai-Wen; Hu, Fung-Rong; Chen, Wei-Li

    2016-01-01

    Abstract Using spectral-domain optical coherence tomography (OCT) to observe the morphology and epithelial thickness (ET) of the palisades of Vogt (POV), and to evaluate the role of age and region on these structures. One hundred twelve eyes of 112 healthy subjects were enrolled and divided into 4 groups: A (0–19), B (20–39), C (40–59), and D (≥60 years old). RTvue-100 OCT was applied on the cornea and the limbus. The morphology of the subepithelial stroma underneath the epithelium of POV was classified into typical and atypical types. Maximum ET of POV was measured manually from OCT images. The positive rate of typical POV in superior, nasal, temporal, and inferior limbus was: Group A: 100%, 69.2%, 65.4%, 100%; Group B: 100%, 73.5%, 61.8%, 94.1%; Group C: 95.8%, 41.7%, 37.5%, 83.3%; Group D: 67.9%, 0%, 3.6%, 25%, showing a significant decreasing tendency with age. The maximum ET of POV in superior, nasal, temporal, and inferior limbus was: Group A: 103.5 ± 10.1 um, 89.2 ± 9.7 um, 87.9 ± 13.6 um, 104.7 ± 14.1 um; Group B: 111.4 ± 15.8 um, 85.3 ± 9.9 um, 88.2 ± 8.6 um, 112.6 ± 19.7 um; Group C: 116.4 ± 16.4 um, 82.8 ± 11.6 um, 87.0 ± 11.6 um, 120.0 ± 25.6 um; Group D: 96.3 ± 17.9 um, 73.8 ± 15.9 um, 79.2 ± 16.7 um, 87.4 ± 18.5 um. Age-dependent change was observed. In general, the maximum ET of POV in superior/inferior quadrants was thicker than the other 2 quadrants. Spectral-domain OCT is a useful tool to observe the limbal microstructure and provide invaluable information. Aging and anatomic regions had significant effects on the microstructure of these areas. PMID:27583846

  9. 77 FR 69498 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... & Columbia Aves., Calvert Rd., & UM Campus, College Park, 12000993 MASSACHUSETTS Hampshire County Northampton..., Auburn, Bird, Claremont, Elmwood, Forest, Highland, Hodge, Lafayette, Lexington, Norwood Aves.,...

  10. Cataloging the Youngest Protostars in NGC2264

    NASA Astrophysics Data System (ADS)

    Barnes, Jonathan; Brown, Arianna; Terebey, Susan; CSI2264

    2016-06-01

    Protostars are young stars in their earliest stages of development. We can determine the current stage of development of a young star depending on its relative brightness at varying wavelengths. Protostars are brightest at far-infrared wavelengths, typically peaking at 70-100um. A previous catalog of young stars in NGC 2264 is based on Spitzer data with 24um being the longest available wavelength data. Herschel data at 70um was used to improve the census of protostars. We found 11 new class 0 and 1 protostar candidates that were previously not found in the Spitzer catalog and are bright at 70um. We describe the properties of these candidates.

  11. VizieR Online Data Catalog: Young clumps embedded in IRDC (Traficante+, 2015)

    NASA Astrophysics Data System (ADS)

    Traficante, A.; Fuller, G. A.; Peretto, N.; Pineda, J. E.; Molinari, S.

    2015-06-01

    Photometric parameters for 667 starless clumps (sources identified at 160um with a counterpart at 250 and 350um) and 1056 protostellar clumps (sources identified at 160um with a counterpart at 70, 250 and 350um). Photometric parameters obtained with Hyper photometry code (2015A&A...574A.119T). The photometry is corrected for aperture and colour corrections. The parameter list is the standard Hyper output (see description below). SED fit parameters for 650 starless clumps and 1034 protostellar clumps (all clumps with good SED fitting: Chi2<10, Temperature<40K. See the paper for details) (4 data files).

  12. Biological properties and molecular targets of umbelliprenin--a mini-review.

    PubMed

    Shakeri, Abolfazl; Iranshahy, Milad; Iranshahi, Mehrdad

    2014-01-01

    7-Prenyloxycoumarins are a group of secondary metabolites found mainly in plants belonging to the families Rutaceae and Apiaceae. Auraptene, umbelliprenin (UM), and 7-isopentenyloxycoumarin are some examples of prenylated coumarins. UM occurs in various edible plant species including celery, coriander, angelica, lemon, and particularly, Ferula species. Although UM was isolated more than 50 years ago, its biological activities have been studied since the last two decades. Besides anticancer activities, biological activities including anti-inflammatory, antioxidant, and antileishmanial activities have been reported from this natural compound. The present mini-review deals with the biological activities and mechanism of actions reported for UM. PMID:24852499

  13. An elementary calculus method for evaluating ?

    NASA Astrophysics Data System (ADS)

    Lee, Tuo Yeong; Xiong, Yuxuan

    2014-08-01

    We use freshman calculus to prove that um0001">um0001.gif"/> for θ ∈ (0, π) and n = 0, 1, 2, … ; in particular, we obtain a simple unified method for evaluating the following infinite series: um0002">um0002.gif"/>

  14. Automated metal-free multiple-column nanoLC for improved phosphopeptide analysis sensitivity and throughput

    SciTech Connect

    Zhao, Rui; Ding, Shi-Jian; Shen, Yufeng; Camp, David G.; Livesay, Eric A.; Udseth, Harold R.; Smith, Richard D.

    2009-03-15

    We report on the development and characterization of an automated metal-free nanoscale multiple-capillary system for reversed-phase liquid chromatography-mass spectrometry analysis of phosphopeptides. The system incorporates a capillary column (50 um i.d. × 30 cm, packed with 5 um C18 particles) coupled on-line to a solid phase extraction column (150 um i.d. × 4 cm, packed with 5 um C18 particles). Electrospray ionization tips are constructed on the packed capillary column to couple the reversed-phase liquid chromatographic separation to a linear ion trap tandem mass spectrometer.

  15. Using optical coherence tomography to assess the role of age and region in corneal epithelium and palisades of vogt.

    PubMed

    Lin, Hsuan-Chieh; Tew, Teck Boon; Hsieh, Yi-Ting; Lin, Szu-Yuan; Chang, Huai-Wen; Hu, Fung-Rong; Chen, Wei-Li

    2016-08-01

    Using spectral-domain optical coherence tomography (OCT) to observe the morphology and epithelial thickness (ET) of the palisades of Vogt (POV), and to evaluate the role of age and region on these structures.One hundred twelve eyes of 112 healthy subjects were enrolled and divided into 4 groups: A (0-19), B (20-39), C (40-59), and D (≥60 years old). RTvue-100 OCT was applied on the cornea and the limbus. The morphology of the subepithelial stroma underneath the epithelium of POV was classified into typical and atypical types. Maximum ET of POV was measured manually from OCT images.The positive rate of typical POV in superior, nasal, temporal, and inferior limbus was: Group A: 100%, 69.2%, 65.4%, 100%; Group B: 100%, 73.5%, 61.8%, 94.1%; Group C: 95.8%, 41.7%, 37.5%, 83.3%; Group D: 67.9%, 0%, 3.6%, 25%, showing a significant decreasing tendency with age. The maximum ET of POV in superior, nasal, temporal, and inferior limbus was: Group A: 103.5 ± 10.1 um, 89.2 ± 9.7 um, 87.9 ± 13.6 um, 104.7 ± 14.1 um; Group B: 111.4 ± 15.8 um, 85.3 ± 9.9 um, 88.2 ± 8.6 um, 112.6 ± 19.7 um; Group C: 116.4 ± 16.4 um, 82.8 ± 11.6 um, 87.0 ± 11.6 um, 120.0 ± 25.6 um; Group D: 96.3 ± 17.9 um, 73.8 ± 15.9 um, 79.2 ± 16.7 um, 87.4 ± 18.5 um. Age-dependent change was observed. In general, the maximum ET of POV in superior/inferior quadrants was thicker than the other 2 quadrants.Spectral-domain OCT is a useful tool to observe the limbal microstructure and provide invaluable information. Aging and anatomic regions had significant effects on the microstructure of these areas. PMID:27583846

  16. Mathematik semantologisch verstehen

    NASA Astrophysics Data System (ADS)

    Wille, Rudolf

    Um zu verstehen, was Mathematik ist und bedeutet, reicht es nicht aus, mathematisches Denken und Wissen vielseitig zu erwerben. Hinzukommen muss stets ein angemessenes Verständnis der jeweiligen Bedeutungen mathematischer Denkformen, die in der aktual-realen Welt wirksam werden können. Beim Mathematik-Verstehen sollte es vor allem um ein Vermitteln des Selbstverständnisses der Mathematik, um ein Reflektieren des Bezugs der Mathematik zur realen Welt und um ein Beurteilen von Sinn, Bedeutung und Zusammenhang des Mathematischen in der Welt gehen.

  17. Estimaciones de Prevalencia del VIH por Género y Grupo de Riesgo en Tijuana, México: 2006

    PubMed Central

    Iñiguez-Stevens, Esmeralda; Brouwer, Kimberly C.; Hogg, Robert S.; Patterson, Thomas L.; Lozada, Remedios; Magis-Rodriguez, Carlos; Elder, John P.; Viani, Rolando M.; Strathdee, Steffanie A.

    2010-01-01

    OBJETIVO Estimar la prevalencia del VIH en adultos de 15-49 años de edad en Tijuana, México - en la población general y en subgrupos de riesgo en el 2006. METODOS Se obtuvieron datos demográficos del censo Mexicano del 2005, y la prevalencia del VIH se obtuvo de la literatura. Se construyó un modelo de prevalencia del VIH para la población general y de acuerdo al género. El análisis de sensibilidad consistió en estimar errores estándar del promedio-ponderado de la prevalencia del VIH y tomar derivados parciales con respecto a cada parámetro. RESULTADOS La prevalencia del VIH es 0.54%(N = 4,347) (Rango: 0.22%–0.86%, (N = 1,750–6,944)). Esto sugiere que 0.85%(Rango: 0.39%–1.31%) de los hombres y 0.22%(Rango: 0.04%–0.40%) de las mujeres podrían ser VIH-positivos. Los hombres que tienen sexo con hombres (HSH), las trabajadoras sexuales usuarias de drogas inyectables (MTS-UDI), MTS-noUDI, mujeres UDI, y los hombres UDI contribuyeron las proporciones más elevadas de personas infectadas por el VIH. CONCLUSIONES El número de adultos VIH-positivos entre subgrupos de riesgo en la población de Tijuana es considerable, marcando la necesidad de enforcar las intervenciones de prevención en sus necesidades específicas. El presente modelo estima que hasta 1 en cada 116 adultos podrían ser VIH-positivos. PMID:19685824

  18. Resistance of uveal melanoma to the interstrand cross-linking agent mitomycin C is associated with reduced expression of CYP450R

    PubMed Central

    Gravells, P; Hoh, L; Canovas, D; Rennie, I G; Sisley, K; Bryant, H E

    2011-01-01

    Background: Uveal melanoma (UM) is the most common primary intraocular tumour of adults, frequently metastasising to the liver. Hepatic metastases are difficult to treat and are mainly unresponsive to chemotherapy. To investigate why UM are so chemo-resistant we explored the effect of interstrand cross-linking agents mitomycin C (MMC) and cisplatin in comparison with hydroxyurea (HU). Methods: Sensitivity to MMC, cisplatin and HU was tested in established UM cell lines using clonogenic assays. The response of UM to MMC was confirmed in MTT assays using short-term cultures of primary UM. The expression of cytochrome P450 reductase (CYP450R) was analysed by western blotting, and DNA cross-linking was assessed using COMET analysis supported by γ-H2AX foci formation. Results: Both established cell lines and primary cultures of UM were resistant to the cross-linking agent MMC (in each case P<0.001 in Student's t-test compared with controls). In two established UM cell lines, DNA cross-link damage was not induced by MMC (in both cases P<0.05 in Students's t-test compared with damage induced in controls). In all, 6 out of 6 UMs tested displayed reduced expression of the metabolising enzyme CYP450R and transient expression of CYP450R increased MMC sensitivity of UM. Conclusion: We suggest that reduced expression of CYP450R is responsible for MMC resistance of UM, through a lack of bioactivation, which can be reversed by complementing UM cell lines with CYP450R. PMID:21386838

  19. Closing the Math Achievement Gap: Institutions Find Success with MyMathLab

    ERIC Educational Resources Information Center

    Stewart, Pearl

    2012-01-01

    Institutions find success with Pearson Education's MyMathLab. The Department of Mathematical Sciences at the University of Memphis (UM) reported a narrowing of the achievement gap between Black and White students. According to the study conducted by UM professors and titled "The Effectiveness of Blended Instruction in Postsecondary General…

  20. ALUMINUM DECREASES MUSCARINIC, ADRENERGIC, AND METABOTROPIC RECEPTOR-STIMULATED PHOSPHOINOSITIDE HYDROLYSIS IN HIPPOCAMPAL AND CORTICAL SLICES FROM RAT BRAIN

    EPA Science Inventory

    Effects of aluminum chloride (AlCl3) (0.1 to 1000 um) on inositol phosphate (IP) accumulation stimulated by carbachol (CARB), norepinephrine (NE) or quisqualate (QUIS) were examined in rat hippocampal and cortical slices. n the absence of agonist, only 1000 um AIC1 significantly ...

  1. THE BIMODAL DISTRIBUTION: DEVELOPMENT OF THE CONCEPT OF FINE AND COARSE PARTICLES AS SEPARATE AND DISTINCT COMPONENTS OF AIRBORNE PARTICULATE MATTER

    EPA Science Inventory

    In the early 1970s, it was understood that combustion particles were formed mostly in sizes below 1 um diameter, and windblown dust was suspended in sizes mostly above 1 um diameter. However, particle size distribution was thought of as a single mode. Particles were thought to f...

  2. Measuring cattle feedlot dust using laser diffraction analysis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Considerable amounts of particulate matter (PM), including total suspended particulates (TSP), particulates with equivalent aerodynamic diameter less than or equal to 10 um (PM10), and particulates with equivalent aerodynamic diameter less than or equal to 2.5 um (PM2.5), are emitted from large beef...

  3. NUTRIENT LIMITATION OF PHYTOPLANKTON GROWTH AND PHYSIOLOGY IN A SUBTROPICAL ESTUARY (PENSACOLA BAY, FL)

    EPA Science Inventory

    Phytoplankton nutrient limitation was studied in a sub-estuary of lower Pensacola Bay using several techniques. Results for <5 um and . 5 um phytoplankton were similar. Nutrient-addition bioassays indicated year-round nutrient limitation, in contrast to seasonal patterns often ...

  4. CHARACTERIZATION OF A NEW THERMOPHILIC SULFATE-REDUCING BACTERIUM THERMODESULFOVIBRIO YELLOWSTONII GEN. NOV. AND SP. NOV.: ITS PHYLOGENETIC RELATIONSHIP TO THERMODESULFOBACTERIUM COMMUNE AND THEIR ORIGINS DEEP WITHIN THE BACTERIAL DOMAIN

    EPA Science Inventory

    A thermophilic sulfate-reducing vibrio isolated from thermal vent water in Yellowstone Lake, Wyoming USA, is described. he Gram-negative, curve rod-shaped cells averaged 0.3 um wide and 1.5 um long. hey were motile by means of a single polar flagellum. rowth was observed between ...

  5. Study of factors affecting growth and cold acclimation of Vitis callus cultures

    SciTech Connect

    Deng, L.

    1987-01-01

    In vitro grape tissue culture initiation, growth, and cold acclimation were studied. Factors involved were genotypes, media, plant growth regulators, age, light, temperature, antioxidant, clearing and adsorbing agents, sucrose level, osmotic potential, ABA, chilling and freezing treatments. Murashige and Skoog (MS) medium containing 1 ..mu..M 2,4-d + 0.1 uM Ba, MS containing 1 uM 2,4-D, and woody plant medium containing 1 uM 2,4-D + 0.1 uM BA produced abundant callus tissue for most grape genotypes; either WPM or MS containing 1 uM BA stimulated shoot growth in all the 12 genotypes tested. Adding 1 uM abscisic acid (ABA) to the B5 medium with 1 uM 2,4-D and 0.5 uM BA enhanced growth and quality of Chancellor callus. /sup 3/H-ABA was taken up actively by callus tissue at 12 days after subculture, but by 20 d this effect disappeared. When /sup 14/C-sucrose was added to the medium. /sup 14/C level of cells reached a plateau after 48 h; this plateau was higher if ABA was also present in the medium. Cells on media containing ABA were larger in size, lighter in color, and more loosely connected.

  6. Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma

    PubMed Central

    Dai, Wei; Zhou, Jingfeng; Jin, Bei; Pan, Jingxuan

    2016-01-01

    Uveal melanoma (UM) is the most common intraocular malignancy in adults. Despite improvements in surgical, radiation and chemotherapy treatments, the overall survival of UM and prognosis remain poor. In the present study, we hypothesized that Sirtuin 1 and 2 (SIRT1/2), class III histone deacetylases (HDACs), were critical in controlling the destiny of bulk tumor cells and cancer stem cells (CSCs) of UM. We testified this hypothesis in four lines of UM cells (92.1, Mel 270, Omm 1 and Omm 2.3). Our results showed that inhibition of SIRT1/2 by Tenovin-6 induced apoptosis in UM cells by activating the expression of tumor suppressor genes such as p53 and elevating reactive oxygen species (ROS). Tenovin-6 inhibited the growth of UM cells. Tenovin-6 and vinblastine was synergistic in inducing apoptosis of UM cell line 92.1 and Mel 270. Furthermore, Tenovin-6 eliminated cancer stem cells in 92.1 and Mel 270 cells. In conclusion, our findings suggest that Tenovin-6 may be a promising agent to kill UM bulk tumor cells and CSCs. PMID:26940009

  7. Study Abroad for Chinese University Presidents: How China Is Reforming Higher Education

    ERIC Educational Resources Information Center

    Cook, Constance Ewing

    2008-01-01

    In 2006, the Chinese Ministry of Education sent presidents and party secretaries from its top-ranked universities to the University of Michigan (UM) to learn more about the leadership of research universities. Both the ministry and UM worked hard to make the visit productive, and both parties gained from it. A year later, with the support of the…

  8. USING CERAMIC MEMBRANES TO RECYCLE TWO NONIONIC ALKALINE METAL-CLEANING SOLUTIONS

    EPA Science Inventory

    One ZrO2 ultrafilter (0.05 um pore size) and two a-Al2O3 microfilters (0.2 and 0.8 um) were used to remove one synthetic ester oil and two polyalphaolefin-based and two petroleum hydrocarbon-based oils and greases from two nonionic alkaline cleaning solutions (e.g., Turco 4215-NC...

  9. Taming the "Beast": An Archival Management System Based on EAD

    ERIC Educational Resources Information Center

    Levine, Jennie A.; Evans, Jennifer; Kumar, Amit

    2006-01-01

    In April 2005, the University of Maryland Libraries launched "ArchivesUM" (www.lib.umd.edu/archivesum), an online database of finding aids for manuscript and archival collections using Encoded Archival Description (EAD). "ArchivesUM," however, is only the publicly available end-product of a much larger project-an integrated system that ties…

  10. DEVELOPMENT OF A SAMPLING PROCEDURE FOR LARGE NITROGEN- AND SULFUR-BEARING AEROSOLS

    EPA Science Inventory

    A single-stage impactor was modified to utilize a removable TFE impaction surface mounted on the end of an annular denuder. hen used with a polycarbonate filter coated with silicone oil, its cut point was 2.5 um and bounce was <1% for 8-um particles. ignificant bounce occurred wi...

  11. DIRECT-DEPOSITION INFRARED SPECTROMETRY WITH GAS AND SUPERCRITICAL FLUID CHROMATOGRAPHY

    EPA Science Inventory

    A direct-deposition Fourier transform infrared (FT-IR) system has been evaluated for applicability to gas chromatography (GC) and supercritical fluid chromatography (SFC) of environmental analytes. A 100-um i.d. fused-silica transfer line was used for GC, and a 50-um transfer lin...

  12. Students' Perceptions of Blackboard and Moodle in a Portuguese University

    ERIC Educational Resources Information Center

    Carvalho, Ana; Areal, Nelson; Silva, Joaquim

    2011-01-01

    The use of learning management systems (LMS) has grown considerably in universities around the world. The University of Minho (UM) has pioneered in this area in Portugal, adopting Blackboard as its official LMS. Moodle is also used in UM in scattered initiatives, allowing for interesting comparisons. Previous studies comparing Blackboard and…

  13. The Role of Iron in Libby Amphibole-Induced Lung Injury and Inflammation

    EPA Science Inventory

    Complexation of host iron (Fe) on the surface of inhaled asbestos fibers has been postulated to cause oxidative stress contributing to in vivo pulmonary injury and inflammation. We examined the role of Fe in Libby amphibole (LA; mean length 4.99um ± 4.53 and width 0.28um ± 0.19)...

  14. Description of Globodera ellingtonae n. sp. (Nematoda: Heteroderidae) from Oregon

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A new species of cyst nematode, Globodera ellingtoni, is described from soil collected from a field with a cropping history including potatoes in Oregon. It is characterized in having second-stage juveniles (J2) with a body length of 450 um (365-515), stylet length of 20.9 um (19-22.5) with basal kn...

  15. New forms of Stolz-Cesaró lemma

    NASA Astrophysics Data System (ADS)

    Mortici, Cristinel

    2011-07-01

    The aim of this article is to give new forms of Stolz-Cesaró lemma involving the limit UM0001"> um0001.gif"/>

  16. Elementary proofs of the identities ?, ? and ?

    NASA Astrophysics Data System (ADS)

    Lee, Tuo Yeong; Xiong, Yuxuan

    2014-10-01

    We use a trigonometric identity and elementary calculus to obtain simple proofs of the following identities: UM0001">um0001.gif"/> and ?.

  17. U.S.-MEXICO BORDER PROGRAM ARIZONA BORDER STUDY--PARTICULATE MATTER IN AIR ANALYTICAL RESULTS

    EPA Science Inventory

    The Particulate Matter in Air data set contains analytical results for measurements of 2 particle sizes in 344 air samples over 86 households. Samples were taken by pumping standardized air volumes through filters using impactors with a 10-um outpoint or with a 2.5-um outpoint. ...

  18. Toward a State of Learning (Achieving the Vision III). Strategic Planning for the University of Maryland System.

    ERIC Educational Resources Information Center

    Maryland Univ. System Administration, Adelphi.

    This report provides an overview of the challenges facing the University of Maryland System (UMS) institutions in the coming years and of strategic planning efforts that administrators and faculty must take to meet these challenges. By the year 2002, UMS will need to increase enrollment by 20 percent, increase productivity by 20 percent, and…

  19. SIZE FRACTIONATION OF METALS IN RUNOFF FROM RESIDENTIAL AND HIGHWAY STORM SEWERS

    EPA Science Inventory

    Stormwater sampling for particulate, colloidal and dissolved metals and organic carbon was conducted for several storms at six outfalls draining locally-designated, nonindustrial land uses in Monmouth County, NJ. Samples were initially sequentially filtered through 5 um, 0.45 um...

  20. Darwin als Sehhilfe für die Psychologie - Evolutionspsychologie

    NASA Astrophysics Data System (ADS)

    Schwab, Frank

    Im Folgenden geht es um Einäugige, stereoskopisches Sehen, weite und enge Horizonte, Monokel und Sonnenbrillen. Der Beitrag versucht die Metapher des Sehens und der Sehhilfen anzuwenden, um so zu verdeutlichen, welchen Gewinn die herkömmliche Psychologie durch die Verwendung einer Darwin'schen Brille erlangen kann.

  1. TRIBUTYLTIN AND DEXAMETHASONE INDUCE APOPTOSIS IN RAT THYMOCYTES BY MUTUALLY ANTAGONISTIC MECHANISMS

    EPA Science Inventory

    We observed that rat thymocyte cultures exposed to 1.O'- 2. 5 uM tri-n-butyltin methoxide (TBT) exhibiteda rapid time- and concentration-dependent induction of apoptosis, with > 85% of cells exhibiting reduced DNAcontent within 1 hr after ensure to 2.0 - 2,5 uM TBT. Moreover, wit...

  2. Mode-Area Scaling of Helical-Core Dual-Clad Fiber Lasers and Amplifiers

    SciTech Connect

    Jiang, Z.; Marciante, J.R.

    2005-09-30

    Helical-core, dual-clad fibers have been designed for single-mode operation with 60-um cores and 0.10 NA. Helical fibers are shown to perform where conventional coiled fibers cannot operate, with possible scaling to 200-um-diameter helical cores.

  3. Vienna in the Early Twentieth Century: The Cultural Response to Modernization. Curriculum Units, NEH Institute, Summer 1993.

    ERIC Educational Resources Information Center

    Oregon Univ., Eugene.

    These curriculum units were developed by participants in the National Endowment for the Humanities seminar at the University of Oregon in 1993. The lessons include: (1) "Schule, Freunde, Liebe: Wien um die Jahrhundertwende (School, Friends, Love: Vienna at the Turn of the Century)" (Linda Hansen; Glenn Tetterton-Opheim); (2) "Kultur in Wien um die…

  4. First Results from the ISO-IRAS Faint Galaxy Survey

    NASA Technical Reports Server (NTRS)

    Wolstencroft, R. D.; Wehrle, A. E.; Levine, D. A.

    1997-01-01

    We present the first result from the ISO-IRAS Faint Galaxy Survey (IIFGS), a program designed to obtain ISO observations of the most distant and luminous galaxies in the IRAS Faint Source Survey by filling short gaps in the ISO observing schedule with pairs of 12um ISOCAM AND 90um ISOPHOT observation.

  5. Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers

    PubMed Central

    Abdel-Rahman, Mohamed H; Pilarski, Robert; Cebulla, Colleen M; Massengill, James B; Christopher, Benjamin N; Boru, Getachew; Hovland, Peter; Davidorf, Frederick H

    2013-01-01

    Objective To investigate the potential contribution of germline sequence alterations in the BAP1 gene in uveal melanoma (UM) patients with possible predisposition to hereditary cancer. Design A total of 53 unrelated UM patients with high risk for hereditary cancer and five additional family members of one proband were studied. Mutational screening was carried out by direct sequencing. Results Of the 53 UM patients studied, a single patient was identified with a germline BAP1 truncating mutation, c. 799 C→T (p.Q267X), which segregated in several family members and was associated with UM and other cancers. Biallelic inactivation of BAP1 and decreased BAP1 expression were identified in the UM, lung adenocarcinoma and meningioma tumours from three family members with this germline BAP1 mutation. Germline BAP1 variants of uncertain significance, likely non-pathogenic, were also identified in two additional UM patients. Conclusion This study reports a novel hereditary cancer syndrome caused by a germline BAP1 mutation that predisposes patients to UM, lung carcinoma, meningioma, and possibly other cancers. The results indicate that BAP1 is the candidate gene in only a small subset of hereditary UM, suggesting the contribution of other candidate genes. PMID:21941004

  6. Thermodynamics of Anharmonic Systems: Uncoupled Mode Approximations for Molecules.

    PubMed

    Li, Yi-Pei; Bell, Alexis T; Head-Gordon, Martin

    2016-06-14

    The partition functions, heat capacities, entropies, and enthalpies of selected molecules were calculated using uncoupled mode (UM) approximations, where the full-dimensional potential energy surface for internal motions was modeled as a sum of independent one-dimensional potentials for each mode. The computational cost of such approaches scales the same with molecular size as standard harmonic oscillator vibrational analysis using harmonic frequencies (HO(hf)). To compute thermodynamic properties, a computational protocol for obtaining the energy levels of each mode was established. The accuracy of the UM approximation depends strongly on how the one-dimensional potentials of each modes are defined. If the potentials are determined by the energy as a function of displacement along each normal mode (UM-N), the accuracies of the calculated thermodynamic properties are not significantly improved versus the HO(hf) model. Significant improvements can be achieved by constructing potentials for internal rotations and vibrations using the energy surfaces along the torsional coordinates and the remaining vibrational normal modes, respectively (UM-VT). For hydrogen peroxide and its isotopologs at 300 K, UM-VT captures more than 70% of the partition functions on average. By contrast, the HO(hf) model and UM-N can capture no more than 50%. For a selected test set of C2 to C8 linear and branched alkanes and species with different moieties, the enthalpies calculated using the HO(hf) model, UM-N, and UM-VT are all quite accurate comparing with reference values though the RMS errors of the HO model and UM-N are slightly higher than UM-VT. However, the accuracies in entropy calculations differ significantly between these three models. For the same test set, the RMS error of the standard entropies calculated by UM-VT is 2.18 cal mol(-1) K(-1) at 1000 K. By contrast, the RMS error obtained using the HO model and UM-N are 6.42 and 5.73 cal mol(-1) K(-1), respectively. For a test set

  7. The SDF-1/CXCR4 chemokine axis in uveal melanoma cell proliferation and migration.

    PubMed

    Bi, Jianjun; Li, Peng; Li, Chuanyin; He, Jie; Wang, Ying; Zhang, He; Fan, Xianqun; Jia, Renbing; Ge, Shengfang

    2016-03-01

    The stromal-cell-derived factor 1 (SDF-1)/chemokine receptor 4 (CXCR4) chemokine axis plays a key role in tumor migration. Here, we analyzed the axis in uveal melanoma (UM) proliferation and migration and investigated the effect of a chemical inhibitor of CXCR4, AMD3100, on UM. We found that CXCR4 was expressed in all five UM cell lines tested as well as the retinal pigment epithelium cell line ARPE-19 cells, while CXCR7 was only detected in OM290 and VUP cell lines. SDF-1 promotes the proliferation and migration of OCM-1 and OCM431 cell lines, while AMD3100 weakens this function. Taken together, our results show that the SDF-1/CXCR4 chemokine axis plays a key role in UM cell proliferation and migration and that AMD3100 can alleviate this function, which may offer a hint for UM treatment. PMID:26490988

  8. The mental health of unaccompanied refugee minors on arrival in the host country.

    PubMed

    Vervliet, Marianne; Meyer Demott, Melinda A; Jakobsen, Marianne; Broekaert, Eric; Heir, Trond; Derluyn, Ilse

    2014-02-01

    Despite increasing numbers of unaccompanied refugee minors (UM) in Europe and heightened concerns for this group, research on their mental health has seldom included the factor "time since arrival." As a result, our knowledge of the mental health statuses of UM at specific points in time and over periods in their resettlement trajectories in European host countries is limited. This study therefore examined the mental health of UM shortly after their arrival in Norway (n = 204) and Belgium (n = 103) through the use of self-report questionnaires (HSCL-37A, SLE, RATS, HTQ). High prevalence scores of anxiety, depression and posttraumatic stress disorder (PTSD) symptoms were found. In addition, particular associations were found with the number of traumatic events the UM reported. The results indicate that all UM have high support needs on arrival in the host country. Longitudinal studies following up patterns of continuity and change in their mental health during their trajectories in the host country are necessary. PMID:25130065

  9. In vivo analysis of Caenorhabditis elegans noncoding RNA promoter motifs

    PubMed Central

    Li, Tiantian; He, Housheng; Wang, Yunfei; Zheng, Haixia; Skogerbø, Geir; Chen, Runsheng

    2008-01-01

    Background Noncoding RNAs (ncRNAs) play important roles in a variety of cellular processes. Characterizing the transcriptional activity of ncRNA promoters is therefore a critical step toward understanding the complex cellular roles of ncRNAs. Results Here we present an in vivo transcriptional analysis of three C. elegans ncRNA upstream motifs (UM1-3). Transcriptional activity of all three motifs has been demonstrated, and mutational analysis revealed differential contributions of different parts of each motif. We showed that upstream motif 1 (UM1) can drive the expression of green fluorescent protein (GFP), and utilized this for detailed analysis of temporal and spatial expression patterns of 5 SL2 RNAs. Upstream motifs 2 and 3 do not drive GFP expression, and termination at consecutive T runs suggests transcription by RNA polymerase III. The UM2 sequence resembles the tRNA promoter, and is actually embedded within its own short-lived, primary transcript. This is a structure which is also found at a few plant and yeast loci, and may indicate an evolutionarily very old dicistronic transcription pattern in which a tRNA serves as a promoter for an adjacent snoRNA. Conclusion The study has demonstrated that the three upstream motifs UM1-3 have promoter activity. The UM1 sequence can drive expression of GFP, which allows for the use of UM1::GFP fusion constructs to study temporal-spatial expression patterns of UM1 ncRNA loci. The UM1 loci appear to act in concert with other upstream sequences, whereas the transcriptional activities of the UM2 and UM3 are confined to the motifs themselves. PMID:18680611

  10. Total Proteome Analysis Identifies Migration Defects as a Major Pathogenetic Factor in Immunoglobulin Heavy Chain Variable Region (IGHV)-unmutated Chronic Lymphocytic Leukemia*

    PubMed Central

    Eagle, Gina L.; Zhuang, Jianguo; Jenkins, Rosalind E.; Till, Kathleen J.; Jithesh, Puthen V.; Lin, Ke; Johnson, Gillian G.; Oates, Melanie; Park, Kevin; Kitteringham, Neil R.; Pettitt, Andrew R.

    2015-01-01

    The mutational status of the immunoglobulin heavy chain variable region defines two clinically distinct forms of chronic lymphocytic leukemia (CLL) known as mutated (M-CLL) and unmutated (UM-CLL). To elucidate the molecular mechanisms underlying the adverse clinical outcome associated with UM-CLL, total proteomes from nine UM-CLL and nine M-CLL samples were analyzed by isobaric tags for relative and absolute quantification (iTRAQ)-based mass spectrometry. Based on the expression of 3521 identified proteins, principal component analysis separated CLL samples into two groups corresponding to immunoglobulin heavy chain variable region mutational status. Computational analysis showed that 43 cell migration/adhesion pathways were significantly enriched by 39 differentially expressed proteins, 35 of which were expressed at significantly lower levels in UM-CLL samples. Furthermore, UM-CLL cells underexpressed proteins associated with cytoskeletal remodeling and overexpressed proteins associated with transcriptional and translational activity. Taken together, our findings indicate that UM-CLL cells are less migratory and more adhesive than M-CLL cells, resulting in their retention in lymph nodes, where they are exposed to proliferative stimuli. In keeping with this hypothesis, analysis of an extended cohort of 120 CLL patients revealed a strong and specific association between UM-CLL and lymphadenopathy. Our study illustrates the potential of total proteome analysis to elucidate pathogenetic mechanisms in cancer. PMID:25645933

  11. Genetic markers of pigmentation are novel risk loci for uveal melanoma.

    PubMed

    Ferguson, Robert; Vogelsang, Matjaz; Ucisik-Akkaya, Esma; Rai, Karan; Pilarski, Robert; Martinez, Carlos N; Rendleman, Justin; Kazlow, Esther; Nagdimov, Khagay; Osman, Iman; Klein, Robert J; Davidorf, Frederick H; Cebulla, Colleen M; Abdel-Rahman, Mohamed H; Kirchhoff, Tomas

    2016-01-01

    While the role of genetic risk factors in the etiology of uveal melanoma (UM) has been strongly suggested, the genetic susceptibility to UM is currently vastly unexplored. Due to shared epidemiological risk factors between cutaneous melanoma (CM) and UM, in this study we have selected 28 SNPs identified as risk variants in previous genome-wide association studies on CM or CM-related host phenotypes (such as pigmentation and eye color) and tested them for association with UM risk. By logistic regression analysis of 272 UM cases and 1782 controls using an additive model, we identified five variants significantly associated with UM risk, all passing adjustment for multiple testing. The three most significantly associated variants rs12913832 (OR = 0.529, 95% CI 0.415-0.673; p = 8.47E-08), rs1129038 (OR = 0.533, 95% CI 0.419-0.678; p = 1.19E-07) and rs916977 (OR = 0.465, 95% CI 0.339-0.637; p = 3.04E-07) are correlated (r(2) > 0.5) and map at 15q12 in the region of HERC2/OCA2, which determines eye-color in the human population. Our data provides first evidence that the genetic factors associated with pigmentation traits are risk loci of UM susceptibility. PMID:27499155

  12. Identification of chemoresistant factors by protein expression analysis with iTRAQ for head and neck carcinoma

    PubMed Central

    Nishimura, K; Tsuchiya, Y; Okamoto, H; Ijichi, K; Gosho, M; Fukayama, M; Yoshikawa, K; Ueda, H; Bradford, C R; Carey, T E; Ogawa, T

    2014-01-01

    Background: Cisplatin and other anticancer drugs are important in the treatment of head and neck squamous cell carcinoma; however, some tumours develop drug resistance. If chemoresistance could be determined before treatment, unnecessary drug administration would be avoided. Here, we investigated chemoresistance factors by comprehensive analyses at the protein level. Methods: Four human carcinoma cell lines were used: cisplatin-sensitive UM-SCC-23, UM-SCC-23-CDDPR with acquired cisplatin resistance, naturally cisplatin-resistant UM-SCC-81B, and UM-SCC-23/WR with acquired 5-fluorouracil resistance. Extracted proteins were labelled with iTRAQ and analysed by tandem mass spectrometry to identify resistance. Protein expression was confirmed by western blotting and functional analysis was carried out using siRNA. Results: Thirteen multiple-drug resistance proteins were identified, as well as seven proteins with specific resistance to cisplatin, including α-enolase. Differential expression of these proteins in cisplatin-resistant and -sensitive cell lines was confirmed by western blotting. Functional analysis for α-enolase by siRNA showed that cisplatin sensitivity significantly was increased in UM-SCC-81B and slightly in UM-SCC-23-CDDPR but not in UM-SCC-23/WR cells. Conclusions: We identified proteins thought to mediate anticancer drug resistance using recent proteome technology and identified α-enolase as a true cisplatin chemoresistance factor. Such proteins could be used as biomarkers for anticancer agent resistance and as targets of cancer therapy. PMID:25032734

  13. VizieR Online Data Catalog: MILO. I. HD 7449 radial velocities (Rodigas+, 2016)

    NASA Astrophysics Data System (ADS)

    Rodigas, T. J.; Arriagada, P.; Faherty, J.; Anglada-Escude, G.; Kaib, N.; Butler, R. P.; Shectman, S.; Weinberger, A.; Males, J. R.; Morzinski, K. M.; Close, L. M.; Hinz, P. M.; Crane, J. D.; Thompson, I.; Teske, J.; Diaz, M.; Minniti, D.; Lopez-Morales, M.; Adams, F. C.; Boss, A. P.

    2016-04-01

    We observed HD 7449 using the Magellan Clay Telescope at the Las Campanas Observatory in Chile on the nights of UT 2014 November 5 and 22. We observed the star with VisAO at Ys (0.99um) and with Clio-2 at H (1.65um) and Ks (2.15um) on the first night and with VisAO at r' (0.63um), i' (0.77um), z' (0.91um), and with Clio-2 at J (1.1um) on the second night. RV data on HD 7449 were first acquired as part of the Magellan Planet Search Program, which originally made use of the MIKE echelle spectrometer (R~70000 in the blue and ~50000 in the red; wavelength coverage ranges from 3900 to 6200Å) on the Magellan Clay telescope until 2009 September. HD 7449 was subsequently observed using the Carnegie Magellan/PFS (3880-6680Å with R~80000 in the iodine region). We also included in our analysis RVs measured with HARPS and CORALIE. These RVs were originally reported in Dumusque et al. (2011, J/A+A/535/A55). HARPS data on HD 7449 has been supplemented by the ESO archive. See section 2.2 for further explanations. (1 data file).

  14. Genetic markers of pigmentation are novel risk loci for uveal melanoma

    PubMed Central

    Ferguson, Robert; Vogelsang, Matjaz; Ucisik-Akkaya, Esma; Rai, Karan; Pilarski, Robert; Martinez, Carlos N.; Rendleman, Justin; Kazlow, Esther; Nagdimov, Khagay; Osman, Iman; Klein, Robert J.; Davidorf , Frederick H.; Cebulla, Colleen M.; Abdel-Rahman, Mohamed H.; Kirchhoff , Tomas

    2016-01-01

    While the role of genetic risk factors in the etiology of uveal melanoma (UM) has been strongly suggested, the genetic susceptibility to UM is currently vastly unexplored. Due to shared epidemiological risk factors between cutaneous melanoma (CM) and UM, in this study we have selected 28 SNPs identified as risk variants in previous genome-wide association studies on CM or CM-related host phenotypes (such as pigmentation and eye color) and tested them for association with UM risk. By logistic regression analysis of 272 UM cases and 1782 controls using an additive model, we identified five variants significantly associated with UM risk, all passing adjustment for multiple testing. The three most significantly associated variants rs12913832 (OR = 0.529, 95% CI 0.415–0.673; p = 8.47E-08), rs1129038 (OR = 0.533, 95% CI 0.419–0.678; p = 1.19E-07) and rs916977 (OR = 0.465, 95% CI 0.339–0.637; p = 3.04E-07) are correlated (r2 > 0.5) and map at 15q12 in the region of HERC2/OCA2, which determines eye-color in the human population. Our data provides first evidence that the genetic factors associated with pigmentation traits are risk loci of UM susceptibility. PMID:27499155

  15. Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma

    PubMed Central

    Landreville, Solange; Agapova, Olga A.; Matatall, Katie A.; Kneass, Zachary T.; Onken, Michael D.; Lee, Ryan S.; Bowcock, Anne M.; Harbour, J. William

    2011-01-01

    Purpose Metastasis is responsible for the death of most cancer patients, yet few therapeutic agents are available which specifically target the molecular events that lead to metastasis. We recently showed that inactivating mutations in the tumor suppressor gene BAP1 are closely associated with loss of melanocytic differentiation in uveal melanoma and metastasis (UM). The purpose of this study was to identify therapeutic agents that reverse the phenotypic effects of BAP1 loss in UM. Experimental Design In silico screens were performed to identify therapeutic compounds predicted to differentiate UM cells using Gene Set Enrichment Analysis and Connectivity Map databases. Valproic acid, trichostatin A, LBH-589 and suberoylanilide hydroxamic acid were evaluated for their effects on UM cells using morphologic evaluation, MTS viability assays, BrdU incorporation, flow cytometry, clonogenic assays, gene expression profiling, histone acetylation and ubiquitination assays, and a murine xenograft tumorigenicity model. Results HDAC inhibitors induced morphologic differentiation, cell cycle exit, and a shift to a differentiated, melanocytic gene expression profile in cultured UM cells. Valproic acid inhibited the growth of UM tumors in vivo. Conclusions These findings suggest that HDAC inhibitors may have therapeutic potential for inducing differentiation and prolonged dormancy of micrometastatic disease in UM. PMID:22038994

  16. Combined PKC and MEK inhibition for treating metastatic uveal melanoma.

    PubMed

    Sagoo, M S; Harbour, J W; Stebbing, J; Bowcock, A M

    2014-09-25

    Uveal melanoma (UM) is the most common primary intraocular malignancy and the second most common form of melanoma. UM has a strong tendency for metastatic disease, and no effective treatments have yet been identified. Activating oncogenic mutations are commonly found in GNAQ and GNA11 in UM, and inhibiting key downstream effectors of the GNAQ/11 signaling pathway represents a rational therapeutic approach for treating metastatic UM. Chen et al., doi:10.1038/onc.2013.418, now confirm activation of the MAPK and PKC pathways as a result of GNAQ and GNA11 activating mutations in melanocytes, and they demonstrate that MAPK activation occurs downstream of PKC activation. PKC inhibitors disrupt MAPK signaling and block proliferation of GNAQ/11 mutant UM cell lines and slow the in vivo growth of xenografted UM tumors without inducing their shrinkage. However, a combination of PKC and MEK inhibition led to sustained MAPK pathway inhibition and tumor regression in vivo. Hence, the authors concluded that MEK and PKC inhibition is synergistic, with superior efficacy to treatment of GNAQ/GNA11 mutant UMs with either drug alone. PMID:24413085

  17. Combined PKC and MEK inhibition for treating metastatic uveal melanoma

    PubMed Central

    Sagoo, MS; Harbour, JW; Stebbing, J; Bowcock, AM

    2015-01-01

    Uveal melanoma (UM) is the most common primary intraocular malignancy and the second most common form of melanoma. UM has a strong tendency for metastatic disease, and no effective treatments have yet been identified. Activating oncogenic mutations are commonly found in GNAQ and GNA11 in UM, and inhibiting key downstream effectors of the GNAQ/11 signaling pathway represents a rational therapeutic approach for treating metastatic UM. Chen et al., doi:10.1038/onc.2013.418, now confirm activation of the MAPK and PKC pathways as a result of GNAQ and GNA11 activating mutations in melanocytes, and they demonstrate that MAPK activation occurs downstream of PKC activation. PKC inhibitors disrupt MAPK signaling and block proliferation of GNAQ/11 mutant UM cell lines and slow the in vivo growth of xenografted UM tumors without inducing their shrinkage. However, a combination of PKC and MEK inhibition led to sustained MAPK pathway inhibition and tumor regression in vivo. Hence, the authors concluded that MEK and PKC inhibition is synergistic, with superior efficacy to treatment of GNAQ/GNA11 mutant UMs with either drug alone. PMID:24413085

  18. Total proteome analysis identifies migration defects as a major pathogenetic factor in immunoglobulin heavy chain variable region (IGHV)-unmutated chronic lymphocytic leukemia.

    PubMed

    Eagle, Gina L; Zhuang, Jianguo; Jenkins, Rosalind E; Till, Kathleen J; Jithesh, Puthen V; Lin, Ke; Johnson, Gillian G; Oates, Melanie; Park, Kevin; Kitteringham, Neil R; Pettitt, Andrew R

    2015-04-01

    The mutational status of the immunoglobulin heavy chain variable region defines two clinically distinct forms of chronic lymphocytic leukemia (CLL) known as mutated (M-CLL) and unmutated (UM-CLL). To elucidate the molecular mechanisms underlying the adverse clinical outcome associated with UM-CLL, total proteomes from nine UM-CLL and nine M-CLL samples were analyzed by isobaric tags for relative and absolute quantification (iTRAQ)-based mass spectrometry. Based on the expression of 3521 identified proteins, principal component analysis separated CLL samples into two groups corresponding to immunoglobulin heavy chain variable region mutational status. Computational analysis showed that 43 cell migration/adhesion pathways were significantly enriched by 39 differentially expressed proteins, 35 of which were expressed at significantly lower levels in UM-CLL samples. Furthermore, UM-CLL cells underexpressed proteins associated with cytoskeletal remodeling and overexpressed proteins associated with transcriptional and translational activity. Taken together, our findings indicate that UM-CLL cells are less migratory and more adhesive than M-CLL cells, resulting in their retention in lymph nodes, where they are exposed to proliferative stimuli. In keeping with this hypothesis, analysis of an extended cohort of 120 CLL patients revealed a strong and specific association between UM-CLL and lymphadenopathy. Our study illustrates the potential of total proteome analysis to elucidate pathogenetic mechanisms in cancer. PMID:25645933

  19. Uncooled infrared detectors toward smaller pixel pitch with newly proposed pixel structure

    NASA Astrophysics Data System (ADS)

    Tohyama, Shigeru; Sasaki, Tokuhito; Endoh, Tsutomu; Sano, Masahiko; Katoh, Kouji; Kurashina, Seiji; Miyoshi, Masaru; Yamazaki, Takao; Ueno, Munetaka; Katayama, Haruyoshi; Imai, Tadashi

    2011-06-01

    Since authors have successfully demonstrated uncooled infrared (IR) focal plane array (FPA) with 23.5 um pixel pitch, it has been widely utilized for commercial applications such as thermography, security camera and so on. One of the key issues for uncooled IR detector technology is to shrink the pixel size. The smaller the pixel pitch, the more the IR camera products become compact and the less cost. This paper proposes a new pixel structure with a diaphragm and beams which are placed in different level, to realize an uncooled IRFPA with smaller pixel pitch )<=17 μm). The upper level consists of diaphragm with VOx bolometer and IR absorber layers, while the lower level consists of the two beams, which are designed to place on the adjacent pixels. The test devices of this pixel design with 12 um, 15 um and 17 um pitch have been fabricated on the Si ROIC of QVGA (320 × 240) with 23.5 um pitch. Their performances reveal nearly equal to the IRFPA with 23.5 um pitch. For example, noise equivalent temperature difference (NETD) of 12 μm pixel is 63.1 mK with thermal time constant of 14.5 msec. In addition, this new structure is expected to be more effective for the existing IRFPA with 23.5 um pitch in order to improve the IR responsivity.

  20. Heightened BTK-dependent cell proliferation in unmutated chronic lymphocytic leukemia confers increased sensitivity to ibrutinib

    PubMed Central

    Galanina, Natalie; Nabhan, Chadi; Smith, Sonali M.; Coleman, Morton; Wang, Y. Lynn

    2016-01-01

    In chronic lymphocytic leukemia (CLL), patients with unmutated immunoglobulin heavy chain variable region gene (UM-CLL) have worse outcomes than mutated CLL (M-CLL) following chemotherapy or chemoimmunotherapy. However, in the era of BCR-targeted therapies, the adverse prognostic impact of unmutated IGHV seems to be diminishing, and there are clinical datasets showing unexpected improved responses in UM-CLL. We investigated the biological differences of BTK activity between these subgroups and further compared the impact of ibrutinib on molecular and cellular behaviors. Immunoblotting analysis revealed that phosphorylated active BTK is significantly higher in UM-CLL. Moreover, UM-CLL, compared to M-CLL, displayed a much higher proliferative capacity that was correlated with higher phospho-BTK and greater sensitivity to ibrutinib. In addition, BTK depletion with siRNA led to a more prominent reduction in the proliferation of UM-CLL, suggesting that elevated BTK activity is responsible for increased cell proliferation. Further, cell signaling activity by multiple measurements was consistently higher in UM-CLL accompanied by a higher sensitivity to ibrutinib. These studies link UM-CLL to elevated BCR signaling, heightened BTK-dependent cell proliferation and increased sensitivity to ibrutinib. The prognostic significance of IGHV mutation should be reevaluated in the era of new therapies targeting BCR signaling. PMID:26717038

  1. Expression of EpCAM in uveal melanoma

    PubMed Central

    Odashiro, Danilo N; Odashiro, Alexandre N; Pereira, Patrícia R; Godeiro, Katyanne; Antecka, Emilia; Di Cesare, Sebastian; Burnier, Miguel N

    2006-01-01

    Background Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults, and nearly 40% of UM will develop metastasis that will ultimately lead to death. The Epithelial Cell Adhesion Molecule (EpCAM) is a type I transmembrane glycoprotein expressed by carcinomas of head and neck, ovary, colon, breast, kidney and lung. Recently, antibodies against EpCAM such as Edrecolomab and Catumaxomab were developed, and clinical trials with these antibodies have been used in several types of neoplasia. We studied the expression of EpCAM in UM. Methods 25 enucleated formalin-fixed, paraffin-embedded UM specimens were immunostained for EpCAM. Histopathological analysis of the specimens with regards to prognostic factors such as cell type, largest (linear) tumor dimension, number of mitotic figures, scleral invasion and tumor infiltrating lymphocytes were done. Results None of them was positive for this EpCAM. Conclusion In our report, UM did not express EpCAM. Therefore, it is not a helpful immunohistochemical marker to predict the behavior of UM. Further studies are needed to verify if EpCAM could also be related with prognosis and treatment of UM. PMID:17125516

  2. Bevacizumab and intraocular tumors: an intriguing paradox

    PubMed Central

    Ly, Long V.; Luyten, Gregorius P.M.; Versluis, Mieke; Grossniklaus, Hans E.; van der Velden, Pieter A.; Jager, Martine J.

    2012-01-01

    Purpose Bevacizumab, a humanized monoclonal antibody to vascular endothelial growth factor-A (VEGF-A), was originally developed as an anti-tumor treatment. In ocular oncology, it is being used to treat macular edema due to radiation retinopathy, but it may also be useful for the treatment of primary uveal melanoma (UM) or its metastases. We determined the effect of bevacizumab on the growth of B16F10 cells inside the eye and on B16F10 and UM cells cultured in vitro. Methods B16F10 melanoma cells were placed into the anterior chamber of the eye of C57Bl/6 mice and tumor growth was monitored after injection of different doses of bevacizumab or mock injection. In addition, the effect of bevacizumab on in vitro growth of B16F10 and human UM cells and on the expression of VEGF-A, GLUT-1, and HIF-1α was evaluated. Results Following intraocular injection of bevacizumab into murine B16 tumor-containing eyes, an acceleration of tumor growth was observed, with the occurrence of anterior chamber hemorrhages. Bevacizumab did not affect proliferation of B16F10 cells in vitro, while it inhibited UM cell proliferation. Expression analysis demonstrated that addition of bevacizumab under hypoxic conditions induced VEGF-A, GLUT-1 and HIF-1α in B16F10 cells as well as in UM cell lines and two of four primary UM tumor cultures. Conclusions In contrast with expectations, intraocular injection of bevacizumab stimulated B16F10 melanoma growth in murine eyes. In vitro exposure of B16 and human UM cells to bevacizumab led to paradoxical VEGF-A upregulation. The use of VEGF inhibitors for treatment of macular edema (due to radiation retinopathy) after irradiation of UM should be considered carefully, because of the possible adverse effects on residual UM cells. PMID:23077404

  3. Two Phosphodiesterases from Ustilago Maydis Share Structural and Biochemical Properties with Non-Fungal Phosphodiesterases

    PubMed Central

    Agarwal, Charu; Schultz, David J.; Perlin, Michael H.

    2010-01-01

    The dependence of Protein Kinase A (PKA) activity on cAMP levels is an important facet of the dimorphic switch between budding and filamentous growth as well as for pathogenicity in some fungi. To better understand these processes in the pathogenic fungus Ustilago maydis, we characterized the structure and biochemical functions of two phosphodiesterase (PDE) genes. Phosphodiesterases are enzymes involved in cAMP turnover and thus, contribute to the regulation of the cAMP-PKA signaling pathway. Two predicted homologs of PDEs were identified in the genome of U. maydis and hypothesized to be involved in cAMP turnover, thus regulating activity of the PKA catalytic subunit. Both umpde1 and umpde2 genes contain domains associated with phosphodiesterase activity predicted by InterPro analysis. Biochemical characterization of recombinantly produced UmPde1 (U. maydis Phosphodiesterase I) and UmPde2 demonstrated that both enzymes have phosphodiesterase activity in vitro, yet neither was inhibited by the phosphodiesterase inhibitor IBMX. Moreover, UmPde1 is specific for cAMP, while UmPde2 has broader substrate specificity, utilizing cAMP and cGMP as substrates. In addition, UmPde2 was also found to have nucleotide phosphatase activity that was higher with GMP compared to AMP. These results demonstrate that UmPde1 is a bona fide phosphodiesterase, while UmPde2 has more general activity as a cyclic nucleotide phosphodiesterase and/or GMP/AMP phosphatase. Thus, UmPde1 and UmPde2 likely have important roles in cell morphology and development and share some characteristics with a variety of non-fungal phosphodiesterases. PMID:21687762

  4. Towards reducing the impacts of unwanted movements on identification of motion intentions.

    PubMed

    Li, Xiangxin; Chen, Shixiong; Zhang, Haoshi; Samuel, Oluwarotimi Williams; Wang, Hui; Fang, Peng; Zhang, Xiufeng; Li, Guanglin

    2016-06-01

    Surface electromyogram (sEMG) has been extensively used as a control signal in prosthesis devices. However, it is still a great challenge to make multifunctional myoelectric prostheses clinically available due to a number of critical issues associated with existing EMG based control strategy. One such issue would be the effect of unwanted movements (UMs) that are inadvertently done by users on the performance of movement classification in EMG pattern recognition based algorithms. Since UMs are not considered in training a classifier, they would decay the performance of a trained classifier in identifying the target movements (TMs), which would cause some undesired actions in control of multifunctional prostheses. In this study, the impact of UMs was systemically investigated in both able-bodied subjects and transradial amputees. Our results showed that the UMs would be unevenly classified into all classes of the TMs. To reduce the impact of the UMs on the performance of a classifier, a new training strategy that would categorize all possible UMs into a new movement class was proposed and a metric called Reject Ratio that is a measure of how many UMs is rejected by a trained classifier was adopted. The results showed that the average Reject Ratio across all the participants was greater than 91%, meanwhile the average classification accuracy of TMs was above 99% when UMs occurred. This suggests that the proposed training strategy could greatly reduce the impact of UMs on the performance of the trained classifier in identifying the TMs and may enhance the robustness of myoelectric control in clinical applications. PMID:27093136

  5. DemaDb: an integrated dematiaceous fungal genomes database

    PubMed Central

    Kuan, Chee Sian; Yew, Su Mei; Chan, Chai Ling; Toh, Yue Fen; Lee, Kok Wei; Cheong, Wei-Hien; Yee, Wai-Yan; Hoh, Chee-Choong; Yap, Soon-Joo; Ng, Kee Peng

    2016-01-01

    Many species of dematiaceous fungi are associated with allergic reactions and potentially fatal diseases in human, especially in tropical climates. Over the past 10 years, we have isolated more than 400 dematiaceous fungi from various clinical samples. In this study, DemaDb, an integrated database was designed to support the integration and analysis of dematiaceous fungal genomes. A total of 92 072 putative genes and 6527 pathways that identified in eight dematiaceous fungi (Bipolaris papendorfii UM 226, Daldinia eschscholtzii UM 1400, D. eschscholtzii UM 1020, Pyrenochaeta unguis-hominis UM 256, Ochroconis mirabilis UM 578, Cladosporium sphaerospermum UM 843, Herpotrichiellaceae sp. UM 238 and Pleosporales sp. UM 1110) were deposited in DemaDb. DemaDb includes functional annotations for all predicted gene models in all genomes, such as Gene Ontology, EuKaryotic Orthologous Groups, Kyoto Encyclopedia of Genes and Genomes (KEGG), Pfam and InterProScan. All predicted protein models were further functionally annotated to Carbohydrate-Active enzymes, peptidases, secondary metabolites and virulence factors. DemaDb Genome Browser enables users to browse and visualize entire genomes with annotation data including gene prediction, structure, orientation and custom feature tracks. The Pathway Browser based on the KEGG pathway database allows users to look into molecular interaction and reaction networks for all KEGG annotated genes. The availability of downloadable files containing assembly, nucleic acid, as well as protein data allows the direct retrieval for further downstream works. DemaDb is a useful resource for fungal research community especially those involved in genome-scale analysis, functional genomics, genetics and disease studies of dematiaceous fungi. Database URL: http://fungaldb.um.edu.my PMID:26980516

  6. Prospecting from Space Using ASTER

    NASA Technical Reports Server (NTRS)

    2002-01-01

    15 meter resolution Visible and Near Infrared image (1.2 MB) 30 meter resolution Shortwave Infrared image (1 MB) 90 meter Thermal Infrared image (628 KB) These images of the Saline Valley area, California, were acquired March 30, 2000, by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER). ASTER is the highest resolution instrument aboard NASA's Terra satellite. The images cover a full ASTER scene (60 by 60 km). Each image displays data from a different spectral region, and illustrates the information gained by looking at the Earth's surface in different wavelengths of light. The top image displays visible and near infrared bands 3 (.81um), 2 (.56um), and 1 (.66um) in red, green, and blue (RGB). Vegetation appears red, snow and dry salt lakes are white, and exposed rocks are brown, gray, yellow, and blue. Rock colors mainly reflect the presence of iron minerals, and variations in albedo. The middle image displays short wavelength infrared bands 4 (1.65um), 6 (2.205um), and 8 (2.33um) as RGB. In this wavelength region, clay, carbonate, and sulfate minerals have unique absorption features, resulting in distinct colors in the image. For example, limestones are yellow-green, and purple areas are kaolinite-rich (kaolinite is a clay mineral). The bottom image displays thermal infrared bands 13 (10.6um), 12 (9.1um) and 10 (8.3um) as RGB. In these wavelengths, variations in quartz content are more or less red; carbonate rocks are green, and mafic volcanic rocks are purple (mafic rocks have high proportions of elements like magnesium and iron). ASTER's ability to identify different types of rock and soil from space using thermal infrared wavelengths of light is one of its unique capabilities. Image courtesy NASA, GSFC, MITI, ERSDAC, JAROS, and the U.S./Japan ASTER Science Team.

  7. DemaDb: an integrated dematiaceous fungal genomes database.

    PubMed

    Kuan, Chee Sian; Yew, Su Mei; Chan, Chai Ling; Toh, Yue Fen; Lee, Kok Wei; Cheong, Wei-Hien; Yee, Wai-Yan; Hoh, Chee-Choong; Yap, Soon-Joo; Ng, Kee Peng

    2016-01-01

    Many species of dematiaceous fungi are associated with allergic reactions and potentially fatal diseases in human, especially in tropical climates. Over the past 10 years, we have isolated more than 400 dematiaceous fungi from various clinical samples. In this study, DemaDb, an integrated database was designed to support the integration and analysis of dematiaceous fungal genomes. A total of 92 072 putative genes and 6527 pathways that identified in eight dematiaceous fungi (Bipolaris papendorfii UM 226, Daldinia eschscholtzii UM 1400, D. eschscholtzii UM 1020, Pyrenochaeta unguis-hominis UM 256, Ochroconis mirabilis UM 578, Cladosporium sphaerospermum UM 843, Herpotrichiellaceae sp. UM 238 and Pleosporales sp. UM 1110) were deposited in DemaDb. DemaDb includes functional annotations for all predicted gene models in all genomes, such as Gene Ontology, EuKaryotic Orthologous Groups, Kyoto Encyclopedia of Genes and Genomes (KEGG), Pfam and InterProScan. All predicted protein models were further functionally annotated to Carbohydrate-Active enzymes, peptidases, secondary metabolites and virulence factors. DemaDb Genome Browser enables users to browse and visualize entire genomes with annotation data including gene prediction, structure, orientation and custom feature tracks. The Pathway Browser based on the KEGG pathway database allows users to look into molecular interaction and reaction networks for all KEGG annotated genes. The availability of downloadable files containing assembly, nucleic acid, as well as protein data allows the direct retrieval for further downstream works. DemaDb is a useful resource for fungal research community especially those involved in genome-scale analysis, functional genomics, genetics and disease studies of dematiaceous fungi. Database URL: http://fungaldb.um.edu.my. PMID:26980516

  8. Building a better warbot: ethical issues in the design of unmanned systems for military applications.

    PubMed

    Sparrow, Robert

    2009-06-01

    Unmanned systems in military applications will often play a role in determining the success or failure of combat missions and thus in determining who lives and dies in times of war. Designers of UMS must therefore consider ethical, as well as operational, requirements and limits when developing UMS. I group the ethical issues involved in UMS design under two broad headings, Building Safe Systems and Designing for the Law of Armed Conflict, and identify and discuss a number of issues under each of these headings. As well as identifying issues, I offer some analysis of their implications and how they might be addressed. PMID:19048395

  9. Unconsummated marriages: a separate and different clinical entity.

    PubMed

    Gindin, Leon Roberto; Resnicoff, Diana

    2002-01-01

    We bring our experience in the treatment of unconsummated marriages (UM). We postulate that it is an independent clinical entity. Since 1991, 199 couples with UM have sought treatment in our center in Buenos Aires. A new approach to this problem is based on an intensive treatment session that lasts a whole day and a pledge to pay only if therapy succeeds. The outcome was a success (97%) with coitus consummation. We make a long-term follow up. The advantages are the brevity of the treatment and lack of desertions. We postulate that UM cannot be approached with an individual perspective or with the usual psychotherapy techniques. PMID:11898713

  10. Landsat 7 - First Cloud-free Image of Yellowstone National Park

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This image of Yellowstone Lake, in the center of Yellowstone National Park, was taken by Landsat 7 on July 13, 1999. Bands 5 (1.65um),4 (.825um), and 2 (.565um) were used for red, green, and blue, respectively. Water appears blue/black, snow light blue, mature forest red/green, young forest pink, and grass and fields appear light green. Southwest of the lake is young forest that is growing in the wake of the widespread fires of 1988. For more information, see: Landsat 7 Fact Sheet Landsat 7 in Mission Control Image by Rich Irish, NASA GSFC

  11. Raízes pós-mitológicas da Astronomia Clássica

    NASA Astrophysics Data System (ADS)

    di Bartolo, L.; Villas da Rocha, J. F.

    2004-02-01

    Apresentamos como a invenção de um modelo astronômico e cosmológico fundado em causas naturais foi um processo gestado num ambiente cultural específico, o do advento do pensamento pós-mitológico, que tem como sua raiz mais funda a trajetória particular da Grécia Antiga, com ênfase na resolução de uma grave crise social e a evolução do mundo clássico para o contexto espiritual de um império universal.

  12. VizieR Online Data Catalog: Spitzer quasar and ULIRG evolution study (Veilleux+, 2009)

    NASA Astrophysics Data System (ADS)

    Veilleux, S.; Rupke, D. S. N.; Kim, D.-C.; Genzel, R.; Sturm, E.; Lutz, D.; Contursi, A.; Schweitzer, M.; Tacconi, L. J.; Netzer, H.; Sternberg, A.; Mihos, J. C.; Baker, A. J.; Mazzarella, J. M.; Lord, S.; Sanders, D. B.; Stockton, A.; Joseph, R. D.; Barnes, J. E.

    2010-01-01

    Galaxies from our own program (#3187; P.I. Veilleux) were observed in the IRS modules SL, SH, and LH, using staring mode. Together, these modules cover observed wavelengths of 5-35um. The high resolution data at observed wavelengths of 10-35um (SH and LH modules, with resolution R~600) allow sensitive measurements of important atomic and molecular emission lines. The ULIRG component of our program focuses on the 1Jy sample, a complete flux-limited sample of 118 ULIRGs selected at 60um from a redshift survey of the IRAS faint source catalog (Kim & Sanders, 1998ApJS..119...41K). (9 data files).

  13. VizieR Online Data Catalog: VY CMa molecular line spectra (Matsuura+, 2014)

    NASA Astrophysics Data System (ADS)

    Matsuura, M.; Yates, J. A.; Barlow, M. J.; Swinyard, B. M.; Royer, P.; Cernicharo, J.; Decin, L.; Wesson, R.; Polehampton, E. T.; Blommaert, J. A. D. L.; Groenewegen, M. A. T.; van de Steene, G. C.; van Hoof, P. A. M.

    2015-03-01

    The Herschel Space Observatory (hereafter Herschel) was launched in 2009 May with three instruments on board: SPIRE, PACS and HIFI . We report here observations made with the SPIRE Fourier Transform Spectrometer (FTS) and with the PACS grating spectrometer, which together cover the wavelength range from 55 to 650um. The SPIRE FTS covers the 190-650um wavelength range, simultaneously, while the PACS spectrometer covers the 55-210um spectral range, similar to that covered by the Long Wavelength Spectrometer (LWS) on board the Infrared Space Observatory (ISO), although with higher spectral resolution and greater sensitivity. (2 data files).

  14. [In Process Citation].

    PubMed

    Petter da Silva, Fhaira; Beatriz Dallepiane, Loiva; Ramos Kirsten, Vanessa; Maria Kirchner, Rosane

    2016-01-01

    Introducción: la esperanza de vida está aumentando y convirtiéndose en un fenómeno característico de los países desarrollados y, cada vez más, de los países en desarrollo, como Brasil. El proceso de envejecimiento produce cambios en algunas funciones fisiológicas, como la pérdida del olfato o gusto o pérdida de apetito, entre otros, que terminan alterando la ingesta de alimentos de estos individuos.Objetivos: este estudio tuvo como objetivo evaluar el consumo de alimentos de los ancianos y de los ancianos más longevos en una ciudad del sur de Brasil.Métodos: un estudio transversal realizado mediante visitas a domicilio en Palmeira das Missões - RS, Brasil. Los datos sociodemográficos, antropométricos y dietéticos fueron recogidos a través de cuestionarios y recordatorio de 24 horas. La adecuación de nutrientes se evaluó de acuerdo con las ingestas de referencia en la dieta. Los datos fueron analizados utilizando el software SPSS 18.0.Resultados: el estudio incluyó a 424 adultos mayores, el 84.4% (n = 358) de ellos menores de 80 años y el 15.6% (n = 66) con más de 80 años. La ingesta de energía y proteínas fue insuficiente tanto para jóvenes adultos como para los más ancianos. El consumo de vitaminas y minerales ha sido insuficiente en todos los adultos mayores a excepción del hierro, que presentaba una ingesta excesiva. Hubo una diferencia estadísticamente significativa entre las personas de edad y mayores sólo en cuanto al consumo de lípidos y vitamina B12. Conclusión: la mayoría de los estudios con personas mayores corrobora los resultados obtenidos en este artículo. Una ingesta inadecuada de nutrientes puede dar lugar a deficiencias nutricionales y, por lo tanto, a cambios fisiológicos y patológicos que pondrían en peligro la capacidad funcional de los ancianos. El consumo de energía y de macronutrientes resultó insuficiente tanto para los ancianos como para los ancianos más longevos. Además, el consumo de vitaminas y

  15. On the Formation of a Study Group to the Realization of Workshops for Teachers: Astronomy in Basic Education in Umuarama-Pr (Spanish Title: De la Formación de un Grupo de Estudios a la Realización de los Talleres Para los Profesores: la Astronomía en la Educación Básica en Umuarama-Pr ) Da Formação de um Grupo de Estudos À Realização de Oficinas Para Professores: a Astronomia na Educação Básica em Umuarama-Pr

    NASA Astrophysics Data System (ADS)

    Belusso, Diane; Akira Sakai, Otávio

    2013-12-01

    In this article, we aimed to present the activities developed by the Astronomy Study Group (ASG) to contribute to the dissemination and improvement of the astronomy teaching-learning. The results of a research carried out in schools of Umuarama-PR are shown, with the intention of checking the students' knowledge and interest in relation to Astronomy. It is reported the realization of workshops for Science teachers linked to the Education Regional Nucleus. The research and the workshop execution promoted the direct contact of the study group with the community; the results were used to diagnose the state of astronomy teaching-learning, in the basic education in Umuarama-PR. En este artículo se intenta presentar las actividades desarrolladas por el Grupo de Estudios de Astronomía (GEA) y contribuir para la divulgación y mejoría de la enseñanza-aprendizaje de la Astronomía. Se presentan los resultados de una investigación realizada en las escuelas de Umuarama-PR, con la intención de determinar el grado de conocimiento y el interés de los estudiantes en relación a la astronomía. Se relata la realización de talleres de capacitación para los profesores de ciencias vinculados al Núcleo Regional del Educación. La ejecución de la investigación y de los talleres promovió el contacto directo del grupo de estudios con la comunidad; los resultados sirvieron de diagnóstico de la enseñanza aprendizaje de la astronomía en la educación básica en Umuarama-PR. Neste artigo, objetiva-se apresentar as atividades desenvolvidas pelo Grupo de Estudos de Astronomia (GEA) e contribuir para a divulgação e melhoria do ensino-aprendizagem de astronomia. São apresentados os resultados de uma pesquisa realizada nas escolas de Umuarama-PR, com o intuito de averiguar o conhecimento e o interesse dos estudantes em relação à astronomia. Relata-se a realização de oficinas de capacitação para professores de ciências vinculados ao Núcleo Regional de Educação. A execução da pesquisa e das oficinas promoveu o contato direto do grupo de estudos com a comunidade; os resultados serviram de diagnóstico do ensino-aprendizagem de astronomia, na educação básica, em Umuarama-PR.

  16. Urine Monitoring System

    NASA Technical Reports Server (NTRS)

    Feedback, Daniel L.; Cibuzar, Branelle R.

    2009-01-01

    The Urine Monitoring System (UMS) is a system designed to collect an individual crewmember's void, gently separate urine from air, accurately measure void volume, allow for void sample acquisition, and discharge remaining urine into the Waste Collector Subsystem (WCS) onboard the International Space Station. The Urine Monitoring System (UMS) is a successor design to the existing Space Shuttle system and will resolve anomalies such as: liquid carry-over, inaccurate void volume measurements, and cross contamination in void samples. The crew will perform an evaluation of airflow at the ISS UMS urinal hose interface, a calibration evaluation, and a full user interface evaluation. o The UMS can be used to facilitate non-invasive methods for monitoring crew health, evaluation of countermeasures, and implementation of a variety of biomedical research protocols on future exploration missions.

  17. WAKE ISLAND AIRFIELD TERMINAL, BUILDING 1502 LOOKING EAST WITH PHOTO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    WAKE ISLAND AIRFIELD TERMINAL, BUILDING 1502 LOOKING EAST WITH PHOTO SCALE CENTERED ON BUILDING (12/30/2008) - Wake Island Airfield, Terminal Building, West Side of Wake Avenue, Wake Island, Wake Island, UM

  18. VizieR Online Data Catalog: IRDC cores in SCUBA Legacy Catalogue (Parsons+, 2009)

    NASA Astrophysics Data System (ADS)

    Parsons, H.; Thompson, M. A.; Chrysostomou, A.

    2011-08-01

    We present an investigation of candidate infrared dark cloud (IRDC) cores as identified by Simon et al. (2006, Cat. J/ApJ/639/227) located within the Submillimetre Common User Bolometer Array (SCUBA) Legacy Catalogue. After applying a uniform noise cut to the catalogue data, we identify 154 IRDC cores that were detected at 850um and 51 cores that were not. We derive column densities for each core from their 8um extinction and find that the IRDCs detected at 850um have higher column densities (a mean of 1.7x1022cm-2) compared to those cores not detected at 850um (a mean of 1.0x1022cm-2). (3 data files).

  19. 24 CFR 200.942 - Supplementary specific procedural requirements under HUD building product standards and...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... identifying the manufacturing plant location; and (ii) Manufacturer's statement of compliance with UM 44d. (2... administrator-approved laboratory. Three samples of each certified quality shall be taken from the...

  20. 24 CFR 200.942 - Supplementary specific procedural requirements under HUD building product standards and...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... identifying the manufacturing plant location; and (ii) Manufacturer's statement of compliance with UM 44d. (2... administrator-approved laboratory. Three samples of each certified quality shall be taken from the...

  1. Ambipolar Black Phosphorus MOSFETs With Record n-Channel Transconductance

    NASA Astrophysics Data System (ADS)

    Haratipour, Nazila; Koester, Steven J.

    2016-01-01

    Ambipolar black phosphorus MOSFETs with record n-channel extrinsic transconductance are reported. The devices consist of multi-layer black phosphorus aligned to a local back-gate electrode with 10-nm-thick HfO2 gate dielectric. Before passivation, devices with 0.3-um gate length behaved as p-MOSFETs with peak extrinsic transconductance, gm, of 282 uS/um at VDS = -2 V. After passivation, the same devices displayed ambipolar behavior, and when tested as n-MOSFETs, had peak gm = 66 uS/um at VDS = +2 V, and similar devices on the same wafer had gm as high as 80 uS/um. These results are an important step toward realization of high-performance black phosphorus complementary logic circuits.

  2. FIBER OPTIC POINT QUADRAT SYSTEM FOR IMPROVED ACCURACY IN VEGETATION SAMPLING

    EPA Science Inventory

    An automated, fiber optic point quadrat system for vegetation sampling is described. Because the effective point diameter of the system never exceeds 25um it minimizes the substantial errors which can arise with conventional point quadrats. Automatic contact detection eliminates ...

  3. A student authored online medical education textbook: editing patterns and content evaluation of a medical student wiki.

    PubMed

    Thompson, C L; Schulz, Wade L; Terrence, Adam

    2011-01-01

    The University of Minnesota medical student wiki (UMMedWiki) allows students to collaboratively edit classroom notes to support medical education. Since 2007, UMMedWiki has grown to include 1,591 articles that have collectively received 1.2 million pageviews. Although small-scale wikis have become increasingly important, little is known about their dynamics compared to large wikis, such as Wikipedia. To better understand UMMedWiki's management and its potential reproducibility at other medical schools, we used an edit log with 28,000 entries to evaluate the behavior of its student editors. The development of tools to survey UMMedwiki allows for quality comparisons that improve both the wiki and the curriculum itself. We completed a content survey by comparing the UMMedWiki with two types of rubric data: TIME, a medical education taxonomy consisting of 1500 terms and national epidemiological data on 2,100 diseases. PMID:22195202

  4. 76 FR 57748 - National Cancer Institute Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ... HUMAN SERVICES National Institutes of Health National Cancer Institute Notice of Closed Meetings... clearly unwarranted invasion of personal privacy. Name of Committee: National Cancer Institute Special Emphasis Panel; Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts (UM1)....

  5. Basic Physics Data: Measurement of Neutron Multiplicity from Induced Fission

    SciTech Connect

    Pozzi, Sara; Haight, Robert

    2015-05-04

    From October 1 to October 17 a team of researchers from UM visited the LANSCE facility for an experiment during beam-time allotted from October 4 to October 17. A total of 24 detectors were used at LANSCE including liquid organic scintillation detectors (EJ-309), NaI scintillation detectors, and Li-6 enriched glass detectors. It is a double time-offlight (TOF) measurement using spallation neutrons generated by a target bombarded with pulsed high-energy protons. The neutrons travel to an LLNL-manufactured parallel plate avalanche chamber (PPAC) loaded with thin U-235 foils in which fission events are induced. The generated fission neutrons and photons are then detected in a detector array designed and built at UM and shipped to LANSCE. Preparations were made at UM, where setup and proposed detectors were tested. The UM equipment was then shipped to LANSCE for use at the 15L beam of the weapons neutron research (WNR) facility.

  6. EFFECT OF BODY SIZE ON BREATHING PATTERN AND FINE PARTICLE DEPOSITION IN CHILDREN

    EPA Science Inventory

    Inter-child variability in breathing patterns may contribute to variability in fine particle, lung deposition and morbidity in children associated with those particles. Fractional deposition (DF) of fine particles (2um monodisperse, carnauba wax particles) was measured in healthy...

  7. Differences in Hospital Managers', Unit Managers', and Health Care Workers' Perceptions of the Safety Climate for Respiratory Protection.

    PubMed

    Peterson, Kristina; Rogers, Bonnie M E; Brosseau, Lisa M; Payne, Julianne; Cooney, Jennifer; Joe, Lauren; Novak, Debra

    2016-07-01

    This article compares hospital managers' (HM), unit managers' (UM), and health care workers' (HCW) perceptions of respiratory protection safety climate in acute care hospitals. The article is based on survey responses from 215 HMs, 245 UMs, and 1,105 HCWs employed by 98 acute care hospitals in six states. Ten survey questions assessed five of the key dimensions of safety climate commonly identified in the literature: managerial commitment to safety, management feedback on safety procedures, coworkers' safety norms, worker involvement, and worker safety training. Clinically and statistically significant differences were found across the three respondent types. HCWs had less positive perceptions of management commitment, worker involvement, and safety training aspects of safety climate than HMs and UMs. UMs had more positive perceptions of management's supervision of HCWs' respiratory protection practices. Implications for practice improvements indicate the need for frontline HCWs' inclusion in efforts to reduce safety climate barriers and better support effective respiratory protection programs and daily health protection practices. PMID:27056750

  8. Use of the University of Minnesota Biocatalysis/Biodegradation Database for study of microbial degradation

    PubMed Central

    2012-01-01

    Microorganisms are ubiquitous on earth and have diverse metabolic transformative capabilities important for environmental biodegradation of chemicals that helps maintain ecosystem and human health. Microbial biodegradative metabolism is the main focus of the University of Minnesota Biocatalysis/Biodegradation Database (UM-BBD). UM-BBD data has also been used to develop a computational metabolic pathway prediction system that can be applied to chemicals for which biodegradation data is currently lacking. The UM-Pathway Prediction System (UM-PPS) relies on metabolic rules that are based on organic functional groups and predicts plausible biodegradative metabolism. The predictions are useful to environmental chemists that look for metabolic intermediates, for regulators looking for potential toxic products, for microbiologists seeking to understand microbial biodegradation, and others with a wide-range of interests. PMID:22587916

  9. What Are Asbestos-Related Lung Diseases?

    MedlinePlus

    ... the NHLBI on Twitter. What Are Asbestos-Related Lung Diseases? Asbestos-related lung diseases are diseases caused ... peritoneum (PER-ih-to-NE-um). Asbestos-Related Lung Diseases Figure A shows the location of the ...

  10. NEI for Kids: Glossary

    MedlinePlus

    ... Astigmatism (uh-STIG-muh-tiz-um) occurs when light is bent differently depending on where it strikes ... of your eye. It helps your eye focus light so things look sharp and clear. D Diabetes ( ...

  11. Separation of pineal extracts by gelfiltration. VI. Isolation and identification from sheep pineals of biopterin; comparison of the isolated compound with some synthetic pteridines and the biological activity in in vitro and in vivo bioassays.

    PubMed

    van der Have-Kirchberg, M L; de Morée, A; van Laar, J F; Gerwig, G J; Versluis, C; Ebels, I

    1977-01-01

    Aqueous extracts of sheep pineal bodies were separated on Sephadex G-25. Two low molecular weight Sephadex G-25 fractions, F2 and F3, were ultrafiltrated through the Amicon membrane UM-2. The UM-2 filtrate was subsequently filtrated through the ultramembrane UM-05 and the UM-05 filtrate was separated on Sephadex G-10 columns. After paper electrophoresis, preparative paper chromatography was carried out. The fluorescent band showing a Rf value identical with synthetic 6-biopterin was eluted; gas liquid chromatography and mass spectrometry of the isolated compound were carried out. The mass spectra of the isolated compound were shown to be identical with synthetic 6-biopterin. The results of the Crithidia fasciculata test and thinlayer chromatography study revealed that the isolated compound is identical with 6-L-erythro-biopterin. The activities of the isolated compound and of synthetic biopterin in in vitro and in vivo bioassays are demonstrated. PMID:874473

  12. Is there a metabolism of an urban ecosystem? An ecological critique.

    PubMed

    Golubiewski, Nancy

    2012-11-01

    The energy and material flows of a city are often described as urban metabolism (UM), which is put forward as a way to link a city's ecology and economy. UM draws parallels to the biology of individual organisms, yet the analogy is misapplied. In striving to be interdisciplinary, UM makes this organismic comparison rather than identifying the city as an ecosystem, thereby ignoring developments in ecological theory. Using inappropriate rhetoric misdirects researchers, which influences scientific investigation-from problem statements to interpretations. UM is valuable in quantifying the city's use of natural resources but does not achieve a comprehensive, integrated analysis of the urban ecosystem. To realize an interdisciplinary, perhaps transdisciplinary, understanding of urban ecology, researchers need to emphasize the essential tenets of material flows analysis, view the city as an ecosystem, and use language that properly reflects current knowledge, theory, and conceptual frameworks in the foundational disciplines. PMID:22262347

  13. Inflammatory Bowel Disease (For Children)

    MedlinePlus

    ... cases, doctors will do a test called a barium (say: BAIR-ee-um) swallow or an upper ... drink a thick liquid containing a substance called barium. (It can be chalky, but sometimes it's flavored.) ...

  14. Misalignment tolerant efficient inverse taper coupler for silicon waveguide

    NASA Astrophysics Data System (ADS)

    Wang, Peng; Michael, Aron; Kwok, Chee Yee; Chen, Ssu-Han

    2015-12-01

    This paper describes an efficient fiber to submicron silicon waveguide coupling based on an inversely tapered silicon waveguide embedded in a SiO2 waveguide that is suspended in air. The inverse taper waveguide consist of a 50um long and 240nm thick silicon that linearly taper in width from 500nm to 120nm, which is embedded in SiO2. The SiO2 waveguide is 6um wide and 10um long. The simulation results show that the coupling loss of this new approach is 2.7dB including the interface loss at the input and output. The tolerance to fiber misalignment at the input of the coupler is 2um in both horizontal and vertical directions for only 1.5dB additional loss.

  15. The role of Bax and Bcl-2 in gemcitabine-mediated cytotoxicity in uveal melanoma cells.

    PubMed

    Wang, Jing; Jia, Renbing; Zhang, Yidan; Xu, Xiaofang; Song, Xin; Zhou, Yixiong; Zhang, He; Ge, Shengfang; Fan, Xianqun

    2014-02-01

    Gemcitabine (GEM), a new cytotoxic agent, was shown to be effective against uveal melanoma (UM) which is noted for its resistance to chemotherapy. In this study, we found the different sensitivities to GEM in UM cell lines and identified apoptotic cell death as the cause of GEM cytotoxicity. Both UM cell lines showed an increase in Bax protein levels and activation of cleaved Caspase 3. Additionally, SP6.5 cells showed a gradual increase in Bcl-2 expression over time, whereas VUP cells showed almost none. After interfering in the expression of Bcl-2, the sensitivity to GEM was obviously enhanced in SP6.5 cells. These results suggest that an increase in Bax plays a crucial role in apoptotic cell death induced by GEM in the absence of p53. Moreover, inhibition of Bcl-2 expression can efficiently enhance the cytotoxic effect of, and sensitivity to, GEM in UM cells. PMID:24014050

  16. Endocarditis

    MedlinePlus

    ... page from the NHLBI on Twitter. What Is Endocarditis? Endocarditis (EN-do-kar-DI-tis) is an infection ... de-um). The condition also is called infective endocarditis (IE). The term "endocarditis" also is used to ...

  17. VizieR Online Data Catalog: NGC 2264 SCUBA-2 observations (Buckle+, 2015)

    NASA Astrophysics Data System (ADS)

    Buckle, J. V.; Richer, J. S.

    2016-03-01

    The SCUBA-2 observations presented comprise 11h of data collected from 2013 January to December. Continuum observations at 850 and 450um were made using fully sampled 1° diameter circular regions (PONG3600 mapping mode). (2 data files).

  18. ARCHITECTURAL DRAWING, MILITARY AIR COMMAND COMMUNICATION CENTER PRECAST CONCRETE WALL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ARCHITECTURAL DRAWING, MILITARY AIR COMMAND COMMUNICATION CENTER PRECAST CONCRETE WALL DETAILS. DATED 03/15/1971 - Wake Island Airfield, Terminal Building, West Side of Wake Avenue, Wake Island, Wake Island, UM

  19. A VIEW OF FOUNDATION (SLAB ON GRADE) WITH SCALE POLE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    A VIEW OF FOUNDATION (SLAB ON GRADE) WITH SCALE POLE LOOKING INTO SPRINKLER BOX ON EAST SIDE OF BUILDING (01/03/2008) - Wake Island Airfield, Terminal Building, West Side of Wake Avenue, Wake Island, Wake Island, UM

  20. Ultrahigh-resolution OCT of prostate pathology in the clinic using a portable Cr:forsterite laser

    NASA Astrophysics Data System (ADS)

    Hsiung, Pei-Lin; Schneider, Karl; Herz, Paul R.; Bourquin, Stephane; Ko, Tony H.; Li, Xing D.; Fujimoto, James G.; Weinstein, Michael E.; Hirsch, Michelle S.; D'Amico, Anthony V.; Richie, Jerome P.

    2003-07-01

    We demonstrate real time, ultrahigh resolution OCT imaging using a portable mode-locked Cr:forsterite laser. OCT imaging at 5.5 um axial resolution was performed of normal and cancerous human prostate tissue and correlated with histology.

  1. Ultrahigh resolution OCT imaging with a two-dimensional MEMS scanning endoscope

    NASA Astrophysics Data System (ADS)

    Aguirre, Aaron D.; Herz, Paul R.; Chen, Yu; Fujimoto, James G.; Piyawattanametha, Wibool; Fan, Li; Hsu, ShuTing; Fujino, Makoto; Wu, Ming C.; Kopf, Daniel

    2005-04-01

    This paper reports preliminary results from the development and application of a two-dimensional MEMS endoscopic scanner for OCT imaging. A 1 mm diameter mirror provides high aperture over large scan angle and can scan at rates of hundreds of Hz in both axes. The mirror is integrated with focusing optics and a fiber-optic collimator into a package of ~5 mm diameter. Using a broadband femtosecond laser light source, ultrahigh axial image resolution of < 5 um in tissue is achieved at 1.06 um center wavelength. Ultrahigh resolution cross-sectional and three-dimensional OCT imaging is demonstrated with the endoscope with ~12 um transverse resolution and < 5 um axial resolution.

  2. OXIDATION OF NITROPYRIN TO 6-CHOLORPICOLINIC ACID BY THE AMMONIA-OXIDIZING BACTERIUM NOSTROSOMAS EUROPAEA

    EPA Science Inventory

    Suspensions of Nitrosomonas europaea catalyzed the oxidation of the commercial nitrification inhibitor nitrapyrin [2-chloro-6-(trichloromethyl)-pyridine]. apid oxidation of nitrapyrin (at a concentration of 10 uM) required the concomitant oxidation of ammonia, hydroxylamine, or h...

  3. 77 FR 20645 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-05

    ... Panel; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) (UM1). Date: April 24....nih.gov . (Catalogue of Federal Domestic Assistance Program Nos. 93.855, Allergy, Immunology,...

  4. Oncogenic role of microRNA-20a in human uveal melanoma

    PubMed Central

    Zhou, Jinzi; Jiang, Jian; Wang, Shuhong; Xia, Xiaobo

    2016-01-01

    As a member of the microRNA (miR)-17-92 cluster, miR-20a has been indicated to be involved in the regulation of the proliferation and invasion of various cancer cells. Previous studies have observed elevated plasma levels of miR-20a in patients with uveal melanoma (UM), compared with normal controls. In the present study, the potential function of miR-20a in UM was investigated. Reverse transcription-quantitative polymerase chain reaction analysis was performed to detect the expression levels of miR-20a in UM cells and tissues. The functions of miR-20a on cell proliferation, migration and invasion were determined in vitro using 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide and Transwell assays, respectively. The expression levels of miR-20a were significantly increased in the UM cells and tissues (P<0.05). Subsequently, miR-20a mimics were transfected into UM cells, which led to increases in cell growth, migration and invasion activities. By contrast, miR-20a inhibition markedly suppressed the viability and motility of UM cells in vitro. These data provided convincing evidence that miR-20a may function as an oncogenic miRNA, and may be involved in promoting cell growth and motility in the molecular etiology of UM, suggesting its potential as a candidate therapeutic target for the treatment of patients with UM. PMID:27356499

  5. VizieR Online Data Catalog: Orion A North prestellar core properties (Salji+, 2015)

    NASA Astrophysics Data System (ADS)

    Salji, C. J.; Richer, J. S.; Buckle, J. V.; Hatchell, J.; Kirk, H.; Beaulieu, S. F.; Berry, D. S.; Broekhoven-Fiene, H.; Currie, M. J.; Fich, M.; Jenness, T.; Johnstone, D.; Mottram, J. C.; Nutter, D.; Pattle, K.; Pineda, J. E.; Quinn, C.; Tisi, S.; Walker-Smith, S.; Di Francesco, J.; Hogerheijde, M. R.; Ward-Thompson, D.; Bastien, P.; Butner, H.; Chen, M.; Chrysostomou, A.; Coude, S.; Davis, C. J.; Drabek-Maunder, E.; Duarte-Cabral, A.; Fiege, J.; Friberg, P.; Friesen, R.; Fuller, G. A.; Graves, S.; Greaves, J.; Gregson, J.; Holland, W.; Joncas, G.; Kirk, J. M.; Knee, L. B. G.; Mairs, S.; Marsh, K.; Matthews, B. C.; Moriarty-Schieven, G.; Rawlings, J.; Robertson, D.; Rosolowsky, E.; Rumble, D.; Sadavoy, S.; Thomas, H.; Tothill, N.; Viti, S.; White, G. J.; Wilson, C. D.; Wouterloot, J.; Yates, J.; Zhu, M.

    2015-11-01

    Between 2011 November and 2013 October, a total of 23, ~40min observations at 850um and 450um were made of fully sampled 30 and 15 arcmin diameter circular regions using PONG1800 and 900 mapping modes. All observations of Orion A North were conducted during grade 1 or 2 weather defined according to the opacity at 225GHz {tau}225<0.08 and were made under Project IDs MJLSG22 and MJLSG31. (2 data files).

  6. Measuring Broadband IR Irradiance in the Direct Solar Beam (Presentation)

    SciTech Connect

    Reda, I.

    2015-03-01

    Solar and atmospheric science radiometers, e.g. pyranometers, pyrheliometers, and photovoltaic cells are calibrated with traceability to a consensus reference, which is maintained by Absolute Cavity Radiometers (ACRs). The ACR is an open cavity with no window, developed to measure extended broadband direct solar irradiance beyond the ultraviolet and infrared bands below and above 0.2 um and 50 um, respectively. On the other hand, pyranometers and pyrheliometers are developed to measure broadband shortwave irradiance from approximately 0.3 um to 3 um, while the present photovoltaic cells are limited to approximately 0.3 um to 1 um. The broadband mismatch of ACR versus such radiometers causes discrepancy in radiometers' calibration methods that has not been discussed or addressed in the solar and atmospheric science literature. Pyrgeometers are also used for solar and atmospheric science applications and are calibrated with traceability to consensus reference, yet are calibrated during nighttime only, because no consensus reference has yet been established for the daytime longwave irradiance. This poster shows a method to measure the broadband IR irradiance in the direct solar beam from 3 um to 50 um, as a first step that might be used to help develop calibration methods to address the mismatch between broadband ACR and shortwave radiometers, and the lack of a daytime reference for pyrgeometers. The irradiance was measured from sunrise to sunset for 5 days when the sun disk was cloudless; the irradiance varied from approximately 1 Wm-2 to 16 Wm-2 for solar zenith angle from 80 degrees to 16 degrees respectively; estimated uncertainty is 1.5 Wm-2.

  7. Oncogenic mutations in GNAQ occur early in uveal melanoma

    PubMed Central

    Onken, Michael D.; Worley, Lori A.; Long, Meghan D.; Duan, Shenghui; Council, M. Laurin; Bowcock, Anne M.; Harbour, J. William

    2008-01-01

    Purpose Early/initiating oncogenic mutations have been identified for many cancers, but such mutations remain unidentified in uveal melanoma (UM). An extensive search for such mutations was undertaken, focusing on the RAF/MEK/ERK pathway, which is often the target of initiating mutations in other types of cancer. Methods DNA samples from primary UMs were analyzed for mutations in 24 potential oncogenes that affect the RAF/MEK/ERK pathway. For GNAQ, a stimulatory αq G-protein subunit which was recently found to be mutated in uveal melanomas, re-sequencing was expanded to include 67 primary UMs and 22 peripheral blood samples. GNAQ status was analyzed for association with clinical, pathologic, chromosomal, immunohistochemical and transcriptional features. Results Activating mutations at codon 209 were identified in GNAQ in 33/67 (49%) primary UMs, including 2/9 (22%) iris melanomas and 31/58 (54%) posterior UMs. No mutations were found in the other 23 potential oncogenes. GNAQ mutations were not found in normal blood DNA samples. Consistent with GNAQ mutation being an early or initiating event, this mutation was not associated with any clinical, pathologic or molecular features associated with late tumor progression. Conclusions GNAQ mutations occur in about half of UMs, representing the most common known oncogenic mutation in this cancer. The presence of this mutation in tumors at all stages of malignant progression suggests that it is an early event in UM. Mutations in this G-protein provide new insights into UM pathogenesis and could lead to new therapeutic possibilities. PMID:18719078

  8. A Large-Telescope Natural Guide Star AO System

    NASA Technical Reports Server (NTRS)

    Redding, David; Milman, Mark; Needels, Laura

    1994-01-01

    None given. From overview and conclusion:Keck Telescope case study. Objectives-low cost, good sky coverage. Approach--natural guide star at 0.8um, correcting at 2.2um.Concl- Good performance is possible for Keck with natural guide star AO system (SR>0.2 to mag 17+).AO-optimized CCD should b every effective. Optimizing td is very effective.Spatial Coadding is not effective except perhaps at extreme low light levels.

  9. Method of producing superconducting fibers of bismuth strontium calcium copper oxide (Bi(2212) and Bi(2223))

    DOEpatents

    Schwartzkopf, Louis A.

    1991-10-01

    Fibers of Bi(2212) have been produce by pendant drop melt extraction. This technique involves the end of a rod of Bi(2212) melted with a hydrogen-oxygen torch, followed by lowering onto the edge of a spinning wheel. The fibers are up to 15 cm in length with the usual lateral dimensions, ranging from 20 um to 30 um. The fibers require a heat treatment to make them superconducting.

  10. Four derivations of an interesting bilateral series generalizing the series for zeta of 2

    NASA Astrophysics Data System (ADS)

    Wright, Cory; Osler, Thomas J.

    2013-04-01

    We present four derivations of the closed form of the partial fractions expansion UM0001a"> um0001a.gif"/> This interesting series is a generalization of the series ? made famous by Euler.

  11. An elementary proof of the identity ?

    NASA Astrophysics Data System (ADS)

    Ho, Weng Kin; Him Ho, Foo; Lee, Tuo Yeong

    2012-12-01

    This article gives an elementary proof of the famous identity UM0001"> um0001.gif"/> Using nothing more than freshman calculus, the present proof is far simpler than many existing ones. This result also leads directly to Euler's and Neville's identities, as well as the identity ? .

  12. Development and External Validation of a Prognostic Nomogram for Metastatic Uveal Melanoma

    PubMed Central

    Valpione, Sara; Moser, Justin C.; Parrozzani, Raffaele; Bazzi, Marco; Mansfield, Aaron S.; Mocellin, Simone; Pigozzo, Jacopo; Midena, Edoardo; Markovic, Svetomir N.; Aliberti, Camillo; Campana, Luca G.; Chiarion-Sileni, Vanna

    2015-01-01

    Background Approximately 50% of patients with uveal melanoma (UM) will develop metastatic disease, usually involving the liver. The outcome of metastatic UM (mUM) is generally poor and no standard therapy has been established. Additionally, clinicians lack a validated prognostic tool to evaluate these patients. The aim of this work was to develop a reliable prognostic nomogram for clinicians. Patients and Methods Two cohorts of mUM patients, from Veneto Oncology Institute (IOV) (N=152) and Mayo Clinic (MC) (N=102), were analyzed to develop and externally validate, a prognostic nomogram. Results The median survival of mUM was 17.2 months in the IOV cohort and 19.7 in the MC cohort. Percentage of liver involvement (HR 1.6), elevated levels of serum LDH (HR 1.6), and a WHO performance status=1 (HR 1.5) or 2–3 (HR 4.6) were associated with worse prognosis. Longer disease-free interval from diagnosis of UM to that of mUM conferred a survival advantage (HR 0.9). The nomogram had a concordance probability of 0.75 (SE .006) in the development dataset (IOV), and 0.80 (SE .009) in the external validation (MC). Nomogram predictions were well calibrated. Conclusions The nomogram, which includes percentage of liver involvement, LDH levels, WHO performance status and disease free-interval accurately predicts the prognosis of mUM and could be useful for decision-making and risk stratification for clinical trials. PMID:25780931

  13. Carrageenan Gum and Adherent Invasive Escherichia coli in a Piglet Model of Inflammatory Bowel Disease: Impact on Intestinal Mucosa-associated Microbiota.

    PubMed

    Munyaka, Peris M; Sepehri, Shadi; Ghia, Jean-Eric; Khafipour, Ehsan

    2016-01-01

    Inflammatory bowel diseases (IBD) including Crohn's disease (CD), and ulcerative colitis (UC), are chronic conditions characterized by chronic intestinal inflammation. Adherent invasive Escherichia coli (AIEC) pathotype has been increasingly implicated in the etiopathogenesis of IBD. In a 21-day study, we investigated the effects of AIEC strain UM146 inoculation on microbiota profile of the ileal, cecal, ascending and descending colon in a pig model of experimental colitis. Carrageenan gum (CG) was used to induce colitis in weaner piglets whereas AIEC strain UM146 previously isolated from a CD patient was included to investigate a cause or consequence effect in IBD. Treatments were: (1) control; (2) CG; (3) AIEC strain UM146; and (4) CG+UM146. Pigs in groups 2 and 4 received 1% CG in drinking water from day 1 of the study while pigs in groups 3 and 4 were inoculated with UM146 on day 8. Following euthanization on day 21, tissue mucosal scrapings were collected and used for DNA extraction. The V4 region of bacterial 16S rRNA gene was then subjected to Illumina sequencing. Microbial diversity, composition, and the predicted functional metagenome were determined in addition to short chain fatty acids profiles in the digesta and inflammatory cytokines in the intestinal tissue. CG-induced colitis decreased bacterial species richness and shifted community composition. At the phylum level, an increase in Proteobacteria and Deferribacteres and a decrease in Firmicutes, Actinobacteria, and Bacteroidetes were observed in CG and CGUM146 compared to control and UM146. The metabolic capacity of the microbiome was also altered in CG and CGUM146 compared to UM146 and control in the colon. We demonstrated that CG resulted in bacterial dysbiosis and shifted community composition similar to what has been previously observed in IBD patients. However, AIEC strain UM146 alone did not cause any clear changes compared to CG or control in our experimental IBD pig model. PMID:27092122

  14. Carrageenan Gum and Adherent Invasive Escherichia coli in a Piglet Model of Inflammatory Bowel Disease: Impact on Intestinal Mucosa-associated Microbiota

    PubMed Central

    Munyaka, Peris M.; Sepehri, Shadi; Ghia, Jean-Eric; Khafipour, Ehsan

    2016-01-01

    Inflammatory bowel diseases (IBD) including Crohn's disease (CD), and ulcerative colitis (UC), are chronic conditions characterized by chronic intestinal inflammation. Adherent invasive Escherichia coli (AIEC) pathotype has been increasingly implicated in the etiopathogenesis of IBD. In a 21-day study, we investigated the effects of AIEC strain UM146 inoculation on microbiota profile of the ileal, cecal, ascending and descending colon in a pig model of experimental colitis. Carrageenan gum (CG) was used to induce colitis in weaner piglets whereas AIEC strain UM146 previously isolated from a CD patient was included to investigate a cause or consequence effect in IBD. Treatments were: (1) control; (2) CG; (3) AIEC strain UM146; and (4) CG+UM146. Pigs in groups 2 and 4 received 1% CG in drinking water from day 1 of the study while pigs in groups 3 and 4 were inoculated with UM146 on day 8. Following euthanization on day 21, tissue mucosal scrapings were collected and used for DNA extraction. The V4 region of bacterial 16S rRNA gene was then subjected to Illumina sequencing. Microbial diversity, composition, and the predicted functional metagenome were determined in addition to short chain fatty acids profiles in the digesta and inflammatory cytokines in the intestinal tissue. CG-induced colitis decreased bacterial species richness and shifted community composition. At the phylum level, an increase in Proteobacteria and Deferribacteres and a decrease in Firmicutes, Actinobacteria, and Bacteroidetes were observed in CG and CGUM146 compared to control and UM146. The metabolic capacity of the microbiome was also altered in CG and CGUM146 compared to UM146 and control in the colon. We demonstrated that CG resulted in bacterial dysbiosis and shifted community composition similar to what has been previously observed in IBD patients. However, AIEC strain UM146 alone did not cause any clear changes compared to CG or control in our experimental IBD pig model. PMID:27092122

  15. Self-concept, self-esteem and psychopathological symptoms in persons with intellectual disability.

    PubMed

    Garaigordobil, Maite; Pérez, José Ignacio

    2007-05-01

    The purpose of this study is two-fold: (a) to analyze self-concept, self-esteem, and psychopathological symptoms in individuals with and without intellectual disability; and (b) to explore whether there were gender differences in these same variables in both groups. The sample is made up of 170 participants aged 19 to 40, 128 without disability and 42 with intellectual disability. The methodology is descriptive. To measure the variables, three assessment instruments were applied: the "Listado de adjetivos para la evaluaci6n del autoconcepto en adolescentes y adultos" (LAEA; Garaigordobil, in press), the Rosenberg Self-Esteem Scale (RSE; Rosenberg, 1965), and the Revised Symptom Checklist-90 (SCL-90; Derogatis, 1983). The ANOVA showed that participants with intellectual disability scored significantly lower in self-concept and self-esteem, and higher in all the psychopathological symptoms except for somatization. The ANOVA did not reveal significant gender differences in any variables in either of the two groups. PMID:17549887

  16. Clinical analysis of a large kindred with the pallister ulnar-mammary syndrome

    SciTech Connect

    Bamshad, M.; Root, S.; Carey, J.C.

    1996-11-11

    The ulnar-mammary syndrome (UMS) is an autosomal dominant disorder characterized by posterior limb deficiencies or duplications, apocrine/mammary gland hypoplasia and/or dysfunction, abnormal dentition, delayed puberty in males, and genital anomalies. We present the clinical descriptions of 33 members of a six generation kindred with UMS. The number of affected individuals in this family is more than the sum of all previously reported cases of UMS. The clinical expression of UMS is highly variable. While most patients have limb deficiencies, the range of abnormalities extends from hypoplasia of the terminal phalanx of the 5th digit to complete absence of the ulna and 3rd, 4th, and 5th digits. Moreover, affected individuals may have posterior digital duplications with or without contralateral limb deficiencies. Apocrine gland abnormalities range from diminished axillary perspiration with normal breast development and lactation, to complete absence of the breasts and no axillary perspiration. Dental abnormalities include misplaced or absent teeth. Affected males consistently undergo delayed puberty, and both sexes have diminished to absent axillary hair. Imperforate hymen were seen in some affected women. A gene for UMS was mapped to chromosome area 12q23-q24.1. A mutation in the gene causing UMS can interfere with limb patterning in the proximal/distal, anterior/posterior, and dorsal/ventral axes. This mutation disturbs development of the posterior elements of forearm, wrist, and hand while growth and development of the anterior elements remain normal. 24 refs., 4 figs., 1 tab.

  17. Quantification of urban metabolism through coupling with the life cycle assessment framework: concept development and case study

    NASA Astrophysics Data System (ADS)

    Goldstein, Benjamin; Birkved, Morten; Quitzau, Maj-Britt; Hauschild, Michael

    2013-09-01

    Cities now consume resources and produce waste in amounts that are incommensurate with the populations they contain. Quantifying and benchmarking the environmental impacts of cities is essential if urbanization of the world’s growing population is to occur sustainably. Urban metabolism (UM) is a promising assessment form in that it provides the annual sum material and energy inputs, and the resultant emissions of the emergent infrastructural needs of a city’s sociotechnical subsystems. By fusing UM and life cycle assessment (UM-LCA) this study advances the ability to quantify environmental impacts of cities by modeling pressures embedded in the flows upstream (entering) and downstream (leaving) of the actual urban systems studied, and by introducing an advanced suite of indicators. Applied to five global cities, the developed UM-LCA model provided enhanced quantification of mass and energy flows through cities over earlier UM methods. The hybrid model approach also enabled the dominant sources of a city’s different environmental footprints to be identified, making UM-LCA a novel and potentially powerful tool for policy makers in developing and monitoring urban development policies. Combining outputs with socioeconomic data hinted at how these forces influenced the footprints of the case cities, with wealthier ones more associated with personal consumption related impacts and poorer ones more affected by local burdens from archaic infrastructure.

  18. Reduced FANCD2 influences spontaneous SCE and RAD51 foci formation in uveal melanoma and Fanconi anaemia

    PubMed Central

    Gravells, P; Hoh, L; Solovieva, S; Patil, A; Dudziec, E; Rennie, I G; Sisley, K; Bryant, H E

    2013-01-01

    Uveal melanoma (UM) is unique among cancers in displaying reduced endogenous levels of sister chromatid exchange (SCE). Here we demonstrate that FANCD2 expression is reduced in UM and that ectopic expression of FANCD2 increased SCE. Similarly, FANCD2-deficient fibroblasts (PD20) derived from Fanconi anaemia patients displayed reduced spontaneous SCE formation relative to their FANCD2-complemented counterparts, suggesting that this observation is not specific to UM. In addition, spontaneous RAD51 foci were reduced in UM and PD20 cells compared with FANCD2-proficient cells. This is consistent with a model where spontaneous SCEs are the end product of endogenous recombination events and implicates FANCD2 in the promotion of recombination-mediated repair of endogenous DNA damage and in SCE formation during normal DNA replication. In both UM and PD20 cells, low SCE was reversed by inhibiting DNA-PKcs (DNA-dependent protein kinase, catalytic subunit). Finally, we demonstrate that both PD20 and UM are sensitive to acetaldehyde, supporting a role for FANCD2 in repair of lesions induced by such endogenous metabolites. Together, these data suggest FANCD2 may promote spontaneous SCE by influencing which double-strand break repair pathway predominates during normal S-phase progression. PMID:23318456

  19. Force of an actin spring

    NASA Astrophysics Data System (ADS)

    Shin, Jennifer; Mahadevan, L.; Matsudaira, Paul

    2003-03-01

    The acrosomal process of the horseshoe crab sperm is a novel mechanochemical molecular spring that converts its elastic stain energy to mechanical work upon the chemical activation by Ca2+. Twisted and bent, the initial state of the acrosomal bundle features a high degree of complexity in its structure and the energy is believed to be stored in the highly strained actin filaments as an elastic potential energy. When activated, the bundle relaxes from the coil of the highly twisted and bent filaments to its straight conformation at a mean velocity of 15um/s. The mean extension velocity increases dramatically from 3um/s to 27um/s when temperature of the medium is changed from 9.6C to 32C (respective viscosities of 1.25-0.75cp), yet it exhibits a very weak dependence on changes in the medium viscosity (1cp-33cp). These experiments suggest that the uncoiling of the actin spring should be limited not by the viscosity of the medium but by the unlatching events of involved proteins at a molecular level. Unlike the viscosity-limited processes, where force is directly related to the rate of the reaction, a direct measurement is required to obtain the spring force of the acrosomal process. The extending acrosomal bundle is forced to push against a barrier and its elastic buckling response is analyzed to measure the force generated during the uncoiling.

  20. Ga Lithography in Sputtered Niobium for Superconductive Micro and Nanowires.

    SciTech Connect

    Henry, Michael David; Lewis, Rupert M.; Wolfley, Steven L.; Monson, Todd C.

    2014-08-18

    This work demonstrates the use of FIB implanted Ga as a lithographic mask for plasma etching of Nb films. Using a highly collimated Ga beam of a FIB, Nb is implanted 12 nm deep with a 14 nm thick Ga layer providing etch selectivity better than 15:1 with fluorine based etch chemistry. Implanted square test patterns, both 10 um by and 10 um and 100 um by 100 um, demonstrate that doses above than 7.5 x 1015 cm-2 at 30 kV provide adequate mask protection for a 205 nm thick, sputtered Nb film. The resolution of this dry lithographic technique is demonstrated by fabrication of nanowires 75 nm wide by 10 um long connected to 50 um wide contact pads. The residual resistance ratio of patterned Nb films was 3. The superconducting transition temperature, Tc =7.7 K, was measured using MPMS. This nanoscale, dry lithographic technique was extended to sputtered TiN and Ta here and could be used on other fluorine etched superconductors such as NbN, NbSi, and NbTi.

  1. Ga Lithography in Sputtered Niobium for Superconductive Micro and Nanowires.

    DOE PAGESBeta

    Henry, Michael David; Lewis, Rupert M.; Wolfley, Steven L.; Monson, Todd C.

    2014-08-18

    This work demonstrates the use of FIB implanted Ga as a lithographic mask for plasma etching of Nb films. Using a highly collimated Ga beam of a FIB, Nb is implanted 12 nm deep with a 14 nm thick Ga layer providing etch selectivity better than 15:1 with fluorine based etch chemistry. Implanted square test patterns, both 10 um by and 10 um and 100 um by 100 um, demonstrate that doses above than 7.5 x 1015 cm-2 at 30 kV provide adequate mask protection for a 205 nm thick, sputtered Nb film. The resolution of this dry lithographic techniquemore » is demonstrated by fabrication of nanowires 75 nm wide by 10 um long connected to 50 um wide contact pads. The residual resistance ratio of patterned Nb films was 3. The superconducting transition temperature, Tc =7.7 K, was measured using MPMS. This nanoscale, dry lithographic technique was extended to sputtered TiN and Ta here and could be used on other fluorine etched superconductors such as NbN, NbSi, and NbTi.« less

  2. BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells

    PubMed Central

    Ambrosini, Grazia; Sawle, Ashley D.; Musi, Elgilda; Schwartz, Gary K.

    2015-01-01

    Uveal melanoma (UM) is an aggressive intraocular malignancy with limited therapeutic options. Both primary and metastatic UM are characterized by oncogenic mutations in the G-protein alpha subunit q and 11. Furthermore, nearly 40% of UM has amplification of the chromosomal arm 8q and monosomy of chromosome 3, with consequent anomalies of MYC copy number. Chromatin regulators have become attractive targets for cancer therapy. In particular, the bromodomain and extra-terminal (BET) inhibitor JQ1 has shown selective inhibition of c-Myc expression with antiproliferative activity in hematopoietic and solid tumors. Here we provide evidence that JQ1 had cytotoxic activity in UM cell lines carrying Gnaq/11 mutations, while in cells without the mutations had little effects. Using microarray analysis, we identified a large subset of genes modulated by JQ1 involved in the regulation of cell cycle, apoptosis and DNA repair. Further analysis of selected genes determined that the concomitant silencing of Bcl-xL and Rad51 represented the minimal requirement to mimic the apoptotic effects of JQ1 in the mutant cells, independently of c-Myc. In addition, administration of JQ1 to mouse xenograft models of Gnaq-mutant UM resulted in significant inhibition of tumor growth. Collectively, our results define BRD4 targeting as a novel therapeutic intervention against UM with Gnaq/Gna11 mutations. PMID:26397223

  3. BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells.

    PubMed

    Ambrosini, Grazia; Sawle, Ashley D; Musi, Elgilda; Schwartz, Gary K

    2015-10-20

    Uveal melanoma (UM) is an aggressive intraocular malignancy with limited therapeutic options. Both primary and metastatic UM are characterized by oncogenic mutations in the G-protein alpha subunit q and 11. Furthermore, nearly 40% of UM has amplification of the chromosomal arm 8q and monosomy of chromosome 3, with consequent anomalies of MYC copy number. Chromatin regulators have become attractive targets for cancer therapy. In particular, the bromodomain and extra-terminal (BET) inhibitor JQ1 has shown selective inhibition of c-Myc expression with antiproliferative activity in hematopoietic and solid tumors. Here we provide evidence that JQ1 had cytotoxic activity in UM cell lines carrying Gnaq/11 mutations, while in cells without the mutations had little effects. Using microarray analysis, we identified a large subset of genes modulated by JQ1 involved in the regulation of cell cycle, apoptosis and DNA repair. Further analysis of selected genes determined that the concomitant silencing of Bcl-xL and Rad51 represented the minimal requirement to mimic the apoptotic effects of JQ1 in the mutant cells, independently of c-Myc. In addition, administration of JQ1 to mouse xenograft models of Gnaq-mutant UM resulted in significant inhibition of tumor growth.Collectively, our results define BRD4 targeting as a novel therapeutic intervention against UM with Gnaq/Gna11 mutations. PMID:26397223

  4. Angiotensin II type 2 receptor-interacting protein 3a suppresses proliferation, migration and invasion in tongue squamous cell carcinoma via the extracellular signal-regulated kinase-Snai2 pathway

    PubMed Central

    ZHAO, TINGTING; HE, QIANTING; LIU, ZHONGHUA; DING, XUEQIANG; ZHOU, XIAOFENG; WANG, ANXUN

    2016-01-01

    Our previous studies demonstrated that the downregulation of microtubule-associated tumor suppressor 1/angiotensin II type 2 receptor-interacting protein (MTUS1/ATIP) is associated with poor differentiation and prognosis in tongue squamous cell carcinoma (TSCC), and that ATIP1 exerts an antiproliferative effect on TSCC. The aim of the present study was to further investigate the anticancer effect of MTUS1/ATIP3a in TSCC. It was observed that UM1 cells (a TSCC cell line with high migration and invasion ability) exhibited lower expression of ATIP3a compared with UM2 cells (a TSCC cell line with lower migration and invasion ability). Restoration of ATIP3a expression in UM1 cells exerted antiproliferative effects and inhibited migration and invasion, whereas knockdown of ATIP3a promoted proliferation, migration and invasion in UM2 cells. Restoration of ATIP3a expression inhibited the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and the expression of Snai2 and vimentin in UM1 cells, whereas knockdown of ATIP3a promoted the phosphorylation of ERK1/2 and the expression of Snai2 and vimentin in UM2 cells. Therefore, MTUS1/ATIP3a was found to suppress the proliferation, migration and invasion of TSCC cells via the ERK1/2-Snai2 pathway. PMID:26870214

  5. Encefalitis por anticuerpos contra el receptor de NMDA: experiencia con seis pacientes pediátricos. Potencial eficacia del metotrexato

    PubMed Central

    Bravo-Oro, Antonio; Abud-Mendoza, Carlos; Quezada-Corona, Arturo; Dalmau, Josep; Campos-Guevara, Verónica

    2016-01-01

    Introducción La encefalitis por anticuerpos contra el receptor de N-metil-D-aspartato (NMDA) es una entidad cada vez más diagnosticada en edad pediátrica. A diferencia de los adultos, en muchos casos no se asocia a tumores y las manifestaciones iniciales en niños más frecuentes son crisis convulsivas y trastornos del movimiento, mientras que en los adultos predominan las alteraciones psiquiátricas. Casos clínicos Presentamos seis casos pediátricos confirmados con anticuerpos contra la subunidad NR1 del receptor de NMDA en suero y líquido cefalorraquídeo. Cinco de los casos comenzaron con crisis convulsivas como manifestación clínica inicial antes de desarrollar el cuadro clásico de esta entidad. En todos los casos se utilizaron esteroides como primera línea de tratamiento, con los que sólo se observó control de las manifestaciones en uno, por lo que el resto de los pacientes requirió inmunomoduladores de segunda línea. Todos los pacientes recibieron metotrexato como tratamiento inmunomodulador para evitar recaídas y la evolución fue a la mejoría en todos ellos. Conclusiones En nuestra serie de pacientes con encefalitis por anticuerpos contra el receptor de NMDA, ninguno se asoció a tumores. Todos los casos recibieron metotrexato por lo menos durante un año, no observamos eventos adversos clínicos ni por laboratorio, ni hubo secuelas neurológicas ni recaídas durante el tratamiento. Aunque es una serie pequeña y es deseable incrementar el número y tiempo de evolución, consideramos el metotrexato una excelente alternativa como tratamiento inmunomodulador para esta patología. PMID:24150952

  6. Prognostic Implications of Tumor Diameter in Association With Gene Expression Profile for Uveal Melanoma

    PubMed Central

    Walter, Scott D.; Chao, Daniel L.; Feuer, William; Schiffman, Joyce; Char, Devron H.; Harbour, J. William

    2016-01-01

    IMPORTANCE Uveal melanoma (UM) can be divided into prognostically significant subgroups based on a prospectively validated and widely used 15-gene expression profile (GEP) test. Class 1 UMs have a low risk and class 2 UMs have a high risk for metastasis. OBJECTIVE To determine whether any clinicopathologic factors provide independent prognostic information that may enhance the accuracy of the GEP classification. DESIGN, SETTING, AND PARTICIPANTS This retrospective observational study performed at 2 ocular oncology referral centers included 339 patients in a primary cohort and 241 patients in a validation cohort. Both cohorts had a diagnosis of UM arising from the ciliary body and/or choroid. All patients underwent tumor biopsy for GEP prognostic testing. Clinicopathologic variables included patient age and sex, tumor thickness, largest basal tumor diameter (LBD), ciliary body involvement, and pathologic cell type. Patients from the primary cohort were enrolled from November 1, 1998, to March 16, 2012; from the validation cohort, from November 4, 1996, to November 7, 2013. Follow-up for the primary cohort was completed on August 18, 2013; for the validation cohort, December 10, 2013. Data were analyzed from November 12, 2013, to November 25, 2015. MAIN OUTCOME AND MEASURES Progression-free survival (PFS). The secondary outcome was overall survival. RESULTS The primary cohort included 339 patients (175 women [51.6%]; mean [SD] age, 61.8 [13.6] years). The most significant prognostic factor was GEP classification (exp[b], 10.33; 95% CI, 4.30–24.84; P < .001). The only other variable that provided independent prognostic information was LBD (exp[b], 1.13; 95% CI, 1.02–1.26; P = .02). Among class 2 UMs, LBD showed a modest but significant association with PFS (exp[b], 1.13; 95% CI, 1.04–1.24; P = .005). The 5-year actuarial metastasis-free survival estimates (SE) were 97% (3%) for class 1 UMs with LBD of less than 12 mm, 90% (4%) for class 1 UMs with LBD of at

  7. Late Pan-African granite emplacement during regional deformation, evidence from magnetic fabric and structural studies in the Hammamat-Atalla area, Central Eastern Desert of Egypt

    NASA Astrophysics Data System (ADS)

    Greiling, R. O.; de Wall, H.; Sadek, M. F.; Dietl, C.

    2014-11-01

    Field investigations, microstructural observations, and magnetic fabric analyses revealed a polyphase, late Pan-African deformational evolution in the Um Sheqila-Um Had (595 Ma) composite pluton and in the Hammamat and Atalla areas of the Central Eastern Desert of Egypt in Ediacaran times. Major stages are early shortening (NNW-SSE), subsequent strike-slip (NW-SE shear zones), and late shortening (NW-SE). Strain studies on pebbles and xenoliths together with AMS data show a predominance of shallow, NW-SE trending X axes or magnetic lineations, associated with steep, NW-SE striking magnetic foliations. Magnetic fabrics and microstructures indicate a tectonic fabric in the Um Sheqila-Um Had granitoid plutons, which is dominated by steep NW-SE striking foliations and shallow NW-SE trending lineations, similar to those in the high-angle Atalla Shear Zone. There is a change of lineation directions from ESE-WNW at Um Sheqila (oldest) to NW-SE to Um Had II (youngest). This pattern may indicate an influence of strike-slip and is also consistent with NE-SW compression. This holds also true for the asymmetry of the contact aureole, which is extended towards NW, parallel with the trend of the magnetic lineation. The character and orientation of the deformation pattern in the Um Sheqila-Um Had plutons and the Atalla Shear Zone is thus similar to the pattern of the late shortening phase. The intrusion of the Um Sheqila-Um Had granitoid rocks, therefore, took place before the late shortening stage, but postdates early deformation, which, according to published data, was associated with lithospheric thinning in the Central Eastern Desert. Therefore, these Pan-African plutons do not represent the earliest post-deformational intrusions but a late stage of syn-deformational magmatic activity. At a regional scale, this deformation with steep foliations and shallow lineations may also be related with lateral escape tectonics. The pluton emplacement, the importance of transcurrent

  8. Clinico-Pathological Association of Delineated miRNAs in Uveal Melanoma with Monosomy 3/Disomy 3 Chromosomal Aberrations

    PubMed Central

    Venkatesan, Nalini; Kanwar, Jagat; Deepa, Perinkulam Ravi; Khetan, Vikas; Crowley, Tamsyn M.; Raguraman, Rajeswari; Sugneswari, Ganesan; Rishi, Pukhraj; Natarajan, Viswanathan; Biswas, Jyotirmay; Krishnakumar, Subramanian

    2016-01-01

    Purpose To correlate the differentially expressed miRNAs with clinico-pathological features in uveal melanoma (UM) tumors harbouring chromosomal 3 aberrations among South Asian Indian cohort. Methods Based on chromosomal 3 aberration, UM (n = 86) were grouped into monosomy 3 (M3; n = 51) and disomy 3 (D3; n = 35) by chromogenic in-situ hybridisation (CISH). The clinico-pathological features were recorded. miRNA profiling was performed in formalin fixed paraffin embedded (FFPE) UM samples (n = 6) using Agilent, Human miRNA microarray, 8x15KV3 arrays. The association between miRNAs and clinico-pathological features were studied using univariate and multivariate analysis. miRNA-gene targets were predicted using Target-scan and MiRanda database. Significantly dys-regulated miRNAs were validated in FFPE UM (n = 86) and mRNAs were validated in frozen UM (n = 10) by qRT-PCR. Metastasis free-survival and miRNA expressions were analysed by Kaplen-Meier analysis in UM tissues (n = 52). Results Unsupervised analysis revealed 585 differentially expressed miRNAs while supervised analysis demonstrated 82 miRNAs (FDR; Q = 0.0). Differential expression of 8 miRNAs: miR-214, miR-149*, miR-143, miR-146b, miR-199a, let7b, miR-1238 and miR-134 were studied. Gene target prediction revealed SMAD4, WISP1, HIPK1, HDAC8 and C-KIT as the post-transcriptional regulators of miR-146b, miR-199a, miR-1238 and miR-134. Five miRNAs (miR-214, miR146b, miR-143, miR-199a and miR-134) were found to be differentially expressed in M3/ D3 UM tumors. In UM patients with liver metastasis, miR-149* and miR-134 expressions were strongly correlated. Conclusion UM can be stratified using miRNAs from FFPE sections. miRNAs predicting liver metastasis and survival have been identified. Mechanistic linkage of de-regulated miRNA/mRNA expressions provide new insights on their role in UM progression and aggressiveness. PMID:26812476

  9. Non-contact optical measurement of lens capsule thickness during simulated accommodation

    NASA Astrophysics Data System (ADS)

    Ziebarth, Noel; Manns, Fabrice; Acosta, Ana-Carolina; Parel, Jean-Marie

    2005-04-01

    Purpose: To non-invasively measure the thickness of the anterior and posterior lens capsule, and to determine if it significantly changes during accommodation. Methods: Anterior and posterior capsule thickness was measured on post-mortem lenses using a non-contact optical system using a focus-detection technique. The optical system uses a 670nm laser beam delivered to a single-mode fiber coupler. The output of the fiber coupler is focused on the tissue surface using an aspheric lens (NA=0.68) mounted on a translation stage with a motorized actuator. Light reflected from the sample surface is collected by the fiber coupler and sent to a photoreceiver connected to a computer-controlled data acquisition system. Optical intensity peaks are detected when the aspheric lens is focused on the capsule boundaries. The capsule thickness is equal to the distance traveled between two peaks multiplied by the capsule refractive index. Anterior and posterior lens capsule thickness measurements were performed on 18 cynomolgus (age average: 6+/-1 years, range: 4-7 years) eyes, 1 rhesus (age: 2 years) eye, and 12 human (age average: 65+/-16, range: 47-92) eyes during simulated accommodation. The mounted sample was placed under the focusing objective of the optical system so that the light was incident on the center pole. Measurements were taken of the anterior lens capsule in the unstretched and the stretched 5mm states. The lens was flipped, and the same procedure was performed for the posterior lens capsule. Results: The precision of the optical system was determined to be +/-0.5um. The resolution is 4um and the sensitivity is 52dB. The human anterior lens capsule thickness was 6.0+/-1.2um unstretched and 4.9+/-0.9um stretched (p=0.008). The human posterior lens capsule was 5.7+/-1.2um unstretched and 5.7+/-1.4um stretched (p=0.974). The monkey anterior lens capsule thickness was 5.9+/-1.9um unstretched and 4.8+/-1.0um stretched (p=0.002). The monkey posterior lens capsule was 5

  10. Ultrahigh resolution optical coherence tomography imaging of lung structure using Gaussian shaped super continuum sources

    NASA Astrophysics Data System (ADS)

    Nishizawa, N.; Ishida, S.; Ohta, T.; Itoh, K.; Kitatsuji, M.; Ohshima, H.; Hasegawa, Y.; Matsushima, M.; Kawabe, T.

    2011-03-01

    Optical coherence tomography (OCT) is an emerging technology for non-invasive cross-sectional imaging of biological tissue and material with um resolution. In the field of pulmonary medicine, non-invasive high resolution cross-sectional imaging is desired for investigation of diseases in lung. So far, a few works have been reported about OCT imaging of lung. Since the lung consists of alveoli separated by thin wall, ultrahigh resolution (UHR) OCT is supposed to be effective for the imaging of fine structure in lung tissue. In this work, ex vivo cross-sectional imaging of isolated rat and hamster lungs was demonstrated using UHR-OCT. A 120 nm-wide, high-power, Gaussian-like supercontinuum (SC) was generated at wavelength of 0.8 um region. The generated SC was used in a time-domain OCT system, and UHR-OCT imaging was demonstrated. An ultrahigh resolution of 2.9 um in air and 2.1 um in tissue was obtained. The achieved sensitivity was 105 dB. Using this system, ex vivo UHR-OCT imaging of isolated rat and hamster lungs was demonstrated for the first time. The structures of the trachea, visceral pleura, and alveoli were observed clearly. When saline was instilled into the lung, the penetration depth was improved, and clear images of the fine structure of the lung, including alveoli, were observed owing to the index matching effect. We have also demonstrated the UHR-OCT imaging of lung tissue using 1.3 um and 1.7 um SC sources. As the results, owing to the precise structures of lung tissues and index matching by saline, the finest images were observed with 0.8 um UHR-OCT system.

  11. Development of an In-line Urine Monitoring System for the International Space Station

    NASA Technical Reports Server (NTRS)

    Broyan, James Lee, Jr.; Cibuzar, Branelle R.

    2009-01-01

    Exposure to microgravity during space flight causes bone loss when calcium and other metabolic by-products are excreted in urine voids. Frequent and accurate measurement of urine void volume and constituents is thus essential in determining crew bone loss and the effectiveness of the countermeasures that are taken to minimize this loss. Earlier space shuttle Urine Monitoring System (UMS) technology was unable to accurately measure urine void volumes due to the cross-contamination that took place between users, as well as to fluid system instabilities. Crew urine voids are currently collected manually in a flexible plastic bag that contains a known tracer quantity. A crew member must completely mix the contents of this bag before withdrawing a representative syringe sample for later ground analysis. The existing bag system accuracy is therefore highly dependent on mixing technique. The International Space Station (ISS) UMS has been developed as an automated device that collects urine from the Waste and Hygiene Compartment (WHC) urinal funnel interface, separates the urine, measures void volume, and allows for syringe sampling. After the ISS UMS has been used by a crew member, it delivers urine to the WHC for normal processing. The UMS plumbing is then flushed with a small volume of water. The current ISS UMS design incorporates an innovative rotary separator that minimizes foaming, consequently greatly reducing cross-contamination among urine voids (less than 0.5 mL urine) while also providing accurate volume measurements (less than 2 percent error for 100 to 1,000 mL void volumes). ISS UMS performance has been validated through extensive ground tests and reduced-gravity aircraft flights. The locker-sized ISS UMS is currently undergoing a design modification that will permit it to interface with the ISS Node 3 WHC Russian toilet (ACY) hardware. The operating principles, characteristics, and results of this design modification are outlined here.

  12. On telescópio remoto do Observatório Abrahão de Moraes - Obelix

    NASA Astrophysics Data System (ADS)

    Neres, N. L.; Raffaelli, J. C.; Medina Tanco, G. A.; Horvath, J. E.; Maluhy, R.; Martins, A.; Orselli, M. I. V.

    2003-08-01

    Foi desenvolvido um telescópio totalmente automático situado no Observatório Abrahão de Moraes, em Valinhos-SP, que possibilita observações remotas via Internet tanto para fins profissionais como didáticos. Usando um programa navegador da WWW, o observador tem acesso a páginas interativas que permitem não só apontar o telescópio e receber as imagens, como também controlar a abertura e o fechamento da cúpula, monitorar temperatura, umidade e orvalho e receber imagens das câmaras de segurança. O fechamento da cúpula é feito automaticamente em caso de perigo de condensação. O sistema consiste de uma câmara Apogee, uma roda de filtros SBIG modelo CFW-8 com filtros RGB e um telescópio Meade. A observação remota é feita usando programas comerciais da área. Uma caixa de controle com lógica programável controla o movimento da cúpula e a energização do telescópio. Um software em LabView adquire os dados da estação meteorológica, que inclui um sensor de chuva desenvolvido no IAG, e apresenta seus valores atuais e históricos. Usando uma facilidade do próprio LabView, a saída desse software é exportada para a Internet. Um programa em C disponibiliza as imagens das câmaras de segurança usando uma placa de captura de vídeo e um seqüencial de vídeo que foi adaptado para ser controlado pelo PC. O sistema completo já se encontra operacional.

  13. Contralateral prophylactic mastectomy rate stable at major Canadian breast cancer center

    PubMed Central

    Roberts, Amanda; Sandhu, Lakhbir; Cil, Tulin D; Hofer, Stefan O P; Zhong, Toni

    2016-01-01

    AIM: To examine trends of contralateral prophylactic mastectomy (CPM) rates at a Canadian academic breast cancer center. METHODS: A single-institution retrospective cohort study was completed. Women of any age who underwent at least a unilateral mastectomy (UM) for primary unilateral breast carcinoma between January 1, 2004 and December 31, 2010 were included. Patients who underwent CPM on the same day as UM were isolated to create two distinct cohorts. Patient and procedure characteristics were compared across groups using R software (version 3.1.0). The percentage of CPMs per year was determined. The Cochrane-Armitage test was used to assess the trend of CPMs over time. A P value of < 0.05 was considered significant. RESULTS: A total of 811 women met the inclusions/exclusion criteria; 759 (93.6%) underwent UM alone and 52 (6.4%) underwent UM with immediate CPM. The absolute number of procedures (UM and UM + CPM) increased over time, from 83 in 2004 to 147 in 2010 reflecting an increase in mastectomy volume. Annual CPM rates did not increase over time (P = 0.7) and varied between 2.6% to 10.7%. Family history of breast cancer [OR 3.6 (1.8-7.3)] and immediate reconstruction [10.0 (5.2-19.3)] were both significantly associated with CPM. Women who underwent CPM were younger (median age CPM 49 years vs UM 52 years, P < 0.0001) but age less than 50 years was not statistically associated with increased rates of CPM. CONCLUSION: CPM rates from 2004 to 2010 at a high-volume Canadian breast cancer center did not increase over time, in contrast to trends observed in the United States. PMID:27298770

  14. Calcium regulation by temperature-sensitive transient receptor potential channels in human uveal melanoma cells.

    PubMed

    Mergler, Stefan; Derckx, Raissa; Reinach, Peter S; Garreis, Fabian; Böhm, Arina; Schmelzer, Lisa; Skosyrski, Sergej; Ramesh, Niraja; Abdelmessih, Suzette; Polat, Onur Kerem; Khajavi, Noushafarin; Riechardt, Aline Isabel

    2014-01-01

    Uveal melanoma (UM) is both the most common and fatal intraocular cancer among adults worldwide. As with all types of neoplasia, changes in Ca(2+) channel regulation can contribute to the onset and progression of this pathological condition. Transient receptor potential channels (TRPs) and cannabinoid receptor type 1 (CB1) are two different types of Ca(2+) permeation pathways that can be dysregulated during neoplasia. We determined in malignant human UM and healthy uvea and four different UM cell lines whether there is gene and functional expression of TRP subtypes and CB1 since they could serve as drug targets to either prevent or inhibit initiation and progression of UM. RT-PCR, Ca(2+) transients, immunohistochemistry and planar patch-clamp analysis probed for their gene expression and functional activity, respectively. In UM cells, TRPV1 and TRPM8 gene expression was identified. Capsaicin (CAP), menthol or icilin induced Ca(2+) transients as well as changes in ion current behavior characteristic of TRPV1 and TRPM8 expression. Such effects were blocked with either La(3+), capsazepine (CPZ) or BCTC. TRPA1 and CB1 are highly expressed in human uvea, but TRPA1 is not expressed in all UM cell lines. In UM cells, the CB1 agonist, WIN 55,212-2, induced Ca(2+) transients, which were suppressed by La(3+) and CPZ whereas CAP-induced Ca(2+) transients could also be suppressed by CB1 activation. Identification of functional TRPV1, TRPM8, TRPA1 and CB1 expression in these tissues may provide novel drug targets for treatment of this aggressive neoplastic disease. PMID:24084605

  15. Duration of maternal undernutrition differentially alters fetal growth and hormone concentrations.

    PubMed

    Field, M E; Anthony, R V; Engle, T E; Archibeque, S L; Keisler, D H; Han, H

    2015-04-01

    To investigate the impact of duration of maternal undernutrition in twin sheep pregnancies, ewes were either fed 100% (C) or 50% of their nutrient requirements from 28 to 78 d gestational age (dGA) and readjusted to 100% beginning at 79 dGA (LC) or continuously restricted from 28 to 135 dGA (LL). Weights of the fetus, empty carcass, brain, and liver were greater in the LC than LL fetuses at 135 dGA (P ≤ 0.05). Although umbilical vein (UmV) glucose concentrations did not differ, the UmV:umbilical artery (UmA) glucose gradient was smaller (0.26 ± 0.03 vs 0.38 ± 0.03 and 0.39 ± 0.04 mmol L(-1); P ≤ 0.05) in LL than C and LC fetuses, respectively. Umbilical vein concentrations of IGF-1 were less (46.7 ± 5.62 vs 74.3 ± 6.71 ng/mL; P ≤ 0.05) in LL than LC fetuses. Additionally, LL fetuses tended (P ≤ 0.10) to have lower UmA concentrations of insulin (0.24 ± 0.13 vs 0.70 ± 0.15 ng/mL) and IGF-1 (66.6 ± 7.51 vs 91.4 ± 8.97 ng/mL) than LC fetuses. Although most of the observed differences occurred between LC and LL pregnancies, LC fetuses tended (P ≤ 0.10) to have greater UmV and UmA pCO2 than C fetuses. Furthermore, the UmV:UmA O2 content gradient tended to be greater (5.02 ± 0.43 vs 3.41 ± 0.47; P ≤ 0.10) in C than LL fetuses. UmA placental lactogen also tended to be greater (46.6 ± 4.40 vs 31.1 ± 4.69 ng/mL; P ≤ 0.10) in LL than C fetuses. These data suggest that in twin pregnancies, maternal undernutrition followed by realimentation induces a different fetal outcome compared with continuous nutrient restriction, and both may differ physiologically from control fed pregnancies. PMID:25460066

  16. Waves of the Future (for Mars): In-Situ Mid-infrared, Near-infrared, and Visible Spectroscopic Analysis of Antarctic Cryptoendolithic Communities.

    NASA Astrophysics Data System (ADS)

    Hand, K. P.; Calrson, R.; Sun, H.; Anderson, M.; Wynn, W.; Levy, R.

    2005-12-01

    We have analyzed both the surface expression and depth profile of cryptoendolithic microbial communities at Battleship Promontory, in the Dry Valleys of Antarctica. Data was collected on site with an active mid-infrared Fourier transform microspectrometer (2.6 - 15 um), a near-infrared spectrometer (0.9-1.8 um), and a visible spectrometer (0.4-1 um). The trio of instruments are connected to microscopes that yield ~1 mm2 spatial resolution on the sample and they are mounted on two perpendicular motorized stages that allow for spatial scanning over an area of ~2cm2. Here we present results on the surface expression of the subsurface microbes in these three spectral regions and we present results on the analysis of a colonized sample examined in cross section. The former case has direct application to the remote, robotic detection of life within the rocks of Mars and the later case provides fundamental insights into the geological and biological interactions that make the Antarctic cryptoendolithic ecosystems possible. Non-invasive surface detection of cyanobacterial dominated communities was possible through the observation of several distinct bands: the carbon-hydrogen stretching modes (symmetric and asymmetric) for CH, CH2, and CH3 in the regions of 3.3-3.6 um and 3.6-3.7 um; the NH2 scissoring and C=O stretch near 6.0 um; the amide I of beta-pleated structures at ~6.1 um; and the 6.4 um - 6.6 um bands of N-H in plane bend of the amide II functional group. In combination, these bands make a strong case for carbohydrates and proteins associated with life. Not surprisingly, as the integrity of the amorphous silica surface varnish improved, our ability to detected the subsurface biosignature decreased. We note, however, that by utilizing the JPL rock crusher in Antarctica, a device designed to fly on the Mars Science Laboratory mission, the mid-infrared biosignature was easily detected. In the cross-section analysis the mid-infrared data provide a depth profile

  17. Ultramicroscopy as a novel tool to unravel the tropism of AAV gene therapy vectors in the brain.

    PubMed

    Alves, Sandro; Bode, Julia; Bemelmans, Alexis-Pierre; von Kalle, Christof; Cartier, Nathalie; Tews, Björn

    2016-01-01

    Recombinant adeno-associated viral (AAV) vectors have advanced to the vanguard of gene therapy. Numerous naturally occurring serotypes have been used to target cells in various tissues. There is a strong need for fast and dynamic methods which efficiently unravel viral tropism in whole organs. Ultramicroscopy (UM) is a novel fluorescence microscopy technique that images optically cleared undissected specimens, achieving good resolutions at high penetration depths while being non-destructive. UM was applied to obtain high-resolution 3D analysis of AAV transduction in adult mouse brains, especially in the hippocampus, a region of interest for Alzheimer's disease therapy. We separately or simultaneously compared transduction efficacies for commonly used serotypes (AAV9 and AAVrh10) using fluorescent reporter expression. We provide a detailed comparative and quantitative analysis of the transduction profiles. UM allowed a rapid analysis of marker fluorescence expression in neurons with intact projections deep inside the brain, in defined anatomical structures. Major hippocampal neuronal transduction was observed with both vectors, with slightly better efficacy for AAV9 in UM. Glial response and synaptic marker expression did not change post transduction.We propose UM as a novel valuable complementary tool to efficiently and simultaneously unravel tropism of different viruses in a single non-dissected adult rodent brain. PMID:27320056

  18. Medusa consumption and prey selection of silver pomfret Pampus argenteus juveniles

    NASA Astrophysics Data System (ADS)

    Liu, Chunsheng; Zhuang, Zhimeng; Chen, Siqing; Shi, Zhaohong; Yan, Jingping; Liu, Changlin

    2014-01-01

    The current study explored Aurelia aurita and Rhopilema esculent um consumption by silver pomfret juveniles, as well as their prey selection between the two jellyfish species. Silver pomfret juveniles weighing 1±0.1 g actively preyed on both the species. Their daily A. aurita consumption was 11.6 times their own body weights regardless of the size of A. aurita medusae. Their daily R. esculent um consumption was 13, 9.1, 5, and 4.1 times their own body weights when the R. esculentum medusae were 10, 20, 30, and 40 mm in bell diameter, respectively. The survival rates of the R. esculent um were higher than those of the A. aurita. When the R. esculent um medusae were more than 30 mm in bell diameter, their survival rate exceeded 92%. Silver pomfrets serve as a type of potential predators on A. aurita in coastal waters, and they have little influence on R. esculent um with a size exceeding 30 mm. Besides, A. aurita may be able to be used as fish prey in silver pomfret artificial breeding.

  19. Ultramicroscopy as a novel tool to unravel the tropism of AAV gene therapy vectors in the brain

    PubMed Central

    Alves, Sandro; Bode, Julia; Bemelmans, Alexis-Pierre; von Kalle, Christof; Cartier, Nathalie; Tews, Björn

    2016-01-01

    Recombinant adeno-associated viral (AAV) vectors have advanced to the vanguard of gene therapy. Numerous naturally occurring serotypes have been used to target cells in various tissues. There is a strong need for fast and dynamic methods which efficiently unravel viral tropism in whole organs. Ultramicroscopy (UM) is a novel fluorescence microscopy technique that images optically cleared undissected specimens, achieving good resolutions at high penetration depths while being non-destructive. UM was applied to obtain high-resolution 3D analysis of AAV transduction in adult mouse brains, especially in the hippocampus, a region of interest for Alzheimer’s disease therapy. We separately or simultaneously compared transduction efficacies for commonly used serotypes (AAV9 and AAVrh10) using fluorescent reporter expression. We provide a detailed comparative and quantitative analysis of the transduction profiles. UM allowed a rapid analysis of marker fluorescence expression in neurons with intact projections deep inside the brain, in defined anatomical structures. Major hippocampal neuronal transduction was observed with both vectors, with slightly better efficacy for AAV9 in UM. Glial response and synaptic marker expression did not change post transduction.We propose UM as a novel valuable complementary tool to efficiently and simultaneously unravel tropism of different viruses in a single non-dissected adult rodent brain. PMID:27320056

  20. International Space Station Urine Monitoring System Functional Integration and Science Testing

    NASA Technical Reports Server (NTRS)

    Rodriquez, Branelle R.; Broyan, James Lee, Jr.

    2011-01-01

    Exposure to microgravity during human spaceflight needs to be better understood as the human exploration of space requires longer duration missions. It is known that long term exposure to microgravity causes bone loss. Measuring the calcium and other metabolic byproducts in a crew member s urine can evaluate the effectiveness of bone loss countermeasures. The International Space Station (ISS) Urine Monitoring System (UMS) is an automated urine collection device designed to collect urine, separate the urine and air, measure the void volume, and allow for syringe sampling. Accurate measuring and minimal cross-contamination is essential to determine bone loss and the effectiveness of countermeasures. The ISS UMS provides minimal cross-contamination (<0.7 mL urine) and has volume accuracy of 2% between 100 to 1000 mL urine voids. Designed to provide a non-invasive means to collect urine samples from crew members, the ISS UMS operates in-line with the Node 3 Waste and Hygiene Compartment (WHC). The ISS UMS has undergone modifications required to interface with the WHC, including material changes, science algorithm improvements, and software platform revisions. Integrated functional testing was performed to determine the pressure drop, air flow rate, and the maximum amount of fluid capable of being discharged from the UMS to the WHC. This paper will detail the results of the science and the functional integration tests.

  1. Embryonic Zebrafish: Different Phenotypes after Injection of Human Uveal Melanoma Cells.

    PubMed

    van der Ent, Wietske; Burrello, Claudia; de Lange, Mark J; van der Velden, Pieter A; Jochemsen, Aart G; Jager, Martine J; Snaar-Jagalska, B Ewa

    2015-04-01

    Although murine xenograft models for human uveal melanoma (UM) are available, they are of limited utility for screening large compound libraries for the discovery of new drugs. We need new preclinical models which can efficiently evaluate drugs that can treat UM metastases. The zebrafish embryonic model is ideal for drug screening purposes because it allows the investigation of potential antitumor properties of drugs within 1 week. The optical transparency of the zebrafish provides unique possibilities for live imaging of fluorescence-labelled cancer cells and their behavior. In addition, the adaptive immune response, which is responsible for the rejection of transplanted material, is not yet present in the early stages of fish development, and systemic immunosuppression is therefore not required to allow growth of tumor cells. We studied the behavior of UM cells following injection into zebrafish embryos and observed different phenotypes. We also analyzed cell migration, proliferation, formation of micrometastasis and interaction with the host microenvironment. Significant differences were noted between cell lines: cells derived from metastases showed more migration and proliferation than cells derived from the primary tumors. The addition of the c-Met inhibitor crizotinib to the water in which the larvae were kept reduced the migration and proliferation of UM cells expressing c-Met. This indicates the applicability of the zebrafish xenografts for testing novel inhibitory compounds and provides a fast and sensitive in vivo vertebrate model for preclinical drug screening to combat UM. PMID:27171126

  2. Heterologous production and characterization of a chlorogenic acid esterase from Ustilago maydis with a potential use in baking.

    PubMed

    Nieter, Annabel; Kelle, Sebastian; Takenberg, Meike; Linke, Diana; Bunzel, Mirko; Popper, Lutz; Berger, Ralf G

    2016-10-15

    Ustilago maydis, an edible mushroom growing on maize (Zea mays), is consumed as the food delicacy huitlacoche in Mexico. A chlorogenic acid esterase from this basidiomycete was expressed in good yields cultivating the heterologous host Pichia pastoris on the 5L bioreactor scale (reUmChlE; 45.9UL(-1)). In contrast to previously described chlorogenic acid esterases, the reUmChlE was also active towards feruloylated saccharides. The enzyme preferred substrates with the ferulic acid esterified to the O-5 position of arabinose residues, typical of graminaceous monocots, over the O-2 position of arabinose or the O-6 position of galactose residues. Determination of kcat/Km showed that the reUmChlE hydrolyzed chlorogenic acid 18-fold more efficiently than methyl ferulate, p-coumarate or caffeate. Phenolic acids were released by reUmChlE from natural substrates, such as destarched wheat bran, sugar beet pectin and coffee pulp. Treatment of wheat dough using reUmChlE resulted in a noticeable softening indicating a potential application of the enzyme in bakery and confectionery. PMID:27173527

  3. TOXICOLOGY STUDIES OF LEWISITE AND SULFUR MUSTARD AGENTS:GENETIC TOXICITY OF LEWISITE (L) IN CHINESE HAMSTER OVARY CELLS

    SciTech Connect

    Jostes,R.F. Jr.; Sasser, LB; Rausch, R.J.

    1989-05-31

    The cytotoxic clastogenic and mutagenic effects of the arsenic containing vesicant, Lewisite (L) [dichloro(2-chlorovinyl) arsine], have been investigated using Chinese hamster ovary cells. One hour exposures to Lewisite were cytotoxic in uM amounts. The cell survival response yields a D37 of 0.6 uM and an extrapolation number of 2.5. The mutagenic response at the hypoxantnine-guanine phosporibosyl transferase (HGPRT) locus was sporadic and not significantly greater than control values when cells were exposed over a range of 0.125 to2.0 uM. Sister chromatid exchange (SCE) induction, a measure of chromosomal rearrangement, was weakly positive over a range of 0.25 to 1.0 uM but the values were not significantly greater than the control response. Chromosomal aberrations were induced at 0.75 and 1.0 UMin one experiment and 0.5 and 0.75 uM in another experiment. The Induced values were significantly greater than the control values. Lewisite appears to be cytotoxic and clastogenic in our investigations but SCE and mutation at the HGPRT locus are not significantly greater than control values. Lewisita toxicity was in some ways similar to radiomimetic chemicals such as bleomycin.

  4. The Roles of Cloud Drop Effective Radius and LWP in Determining Rain Properties in Marine Stratocumulus

    SciTech Connect

    Rosenfeld, Daniel; Wang, Hailong; Rasch, Philip J.

    2012-07-04

    Numerical simulations described in previous studies showed that adding cloud condensation nuclei to marine stratocumulus can prevent their breakup from closed into open cells. Additional analyses of the same simulations show that the suppression of rain is well described in terms of cloud drop effective radius (re). Rain is initiated when re near cloud top is around 12-14 um. Cloud water starts to get depleted when column-maximum rain intensity (Rmax) exceeds 0.1 mm h-1. This happens when cloud-top re reaches 14 um. Rmax is mostly less than 0.1 mm h-1 at re<14 um, regardless of the cloud water path, but increases rapidly when re exceeds 14 um. This is in agreement with recent aircraft observations and theoretical observations in convective clouds so that the mechanism is not limited to describing marine stratocumulus. These results support the hypothesis that the onset of significant precipitation is determined by the number of nucleated cloud drops and the height (H) above cloud base within the cloud that is required for cloud drops to reach re of 14 um. In turn, this can explain the conditions for initiation of significant drizzle and opening of closed cells providing the basis for a simple parameterization for GCMs that unifies the representation of both precipitating and non-precipitating clouds as well as the transition between them. Furthermore, satellite global observations of cloud depth (from base to top), and cloud top re can be used to derive and validate this parameterization.

  5. Creating a full-sky map of PAH emission

    NASA Astrophysics Data System (ADS)

    Berkeley, Matthew; Kogut, Alan J.; Chuss, David T.; WISE

    2016-06-01

    Accurate characterization of foreground components has been a pressing issue in the CMB community for some time. In particular, the Anomalous Microwave Emission (AME), first detected in 1995 and confirmed by WMAP and Planck, has remained mysterious, though the leading hypothesis proposes that this excess emission is due to electric dipole emission from spinning dust grains. The leading candidate for such ‘spinning dust’ is Polycyclic Aromatic Hydrocarbons (PAHs). PAHs have characteristic emission lines in the mid-IR and can be analyzed using archived data from the WISE satellite. We have been working using publicly available data from WISE to create a full-sky map across the four WISE frequency bands: 3.4um, 4.6um, 12um and 22um. PAH emission is brightest in the 12um band; however it is possible to localize this population more accurately by linearly combining the maps across all four frequencies to create a full-sky map tracing the small-grain population of PAHs.We present preliminary results from this work.

  6. VizieR Online Data Catalog: ISOCAM survey of Serpens/G3-G6 (Djupvik+, 2006)

    NASA Astrophysics Data System (ADS)

    Djupvik, A. A.; Andre, P.; Bontemps, S.; Motte, F.; Olofsson, G.; Gaalfalk, M.; Floren, H.-G.

    2006-08-01

    We present results from an ISOCAM survey in the two broadband filters LW2 (5-8.5um) and LW3 (12-18um) of a 19'x16' field called Serp_NH3 centred on the optical group Serpens/G3-G6. A total of 186 sources were detected in the 6.7um band and/or the 14.3um band to a limiting sensitivity of ~2mJy. These have been cross-correlated with the 2MASS catalogue and are all listed in table1. Deep follow-up photometry in the Ks band obtained with Arnica at the Nordic Optical Telescope (NOT) is listed in table2. Deep L' band photometry of selected sources using SIRCA at the NOT is listed in table3. Continuum emission at 1.3mm and 3.6cm was observed with IRAM and VLA, respectively, and deep imaging in the 2.12um S(1) line of H2 was obtained with NOTCam at the NOT. We find strong evidence for a stellar population of 31 Class II sources (listed in table5), 5 flat-spectrum sources, 5 Class I sources (listed in table4), and two Class 0 sources. Our method does not sample the Class III sources. (3 data files).

  7. Fiber optic TDLAS-based multi-gas remote detection system for mine goaf fire

    NASA Astrophysics Data System (ADS)

    Wei, Yubin; Li, Yanfang; Shang, Ying; Zhang, Tingting; Song, Zhiqiang; Wang, Chang; Liu, Tongyu

    2010-10-01

    Spontaneous combustion in coal goaf area is one of major disasters in coal mines. Detection technology based on signature Gas is the primary means of spontaneous combustion forecasting of coal goaf area. A real-time remote fire gas detection system is proposed based on tunable diode laser absorption spectroscopy technology, to achieve valid test of signature gas (CO, CO2, CH4, C2H2 and C2H4). The System uses the wavelength, respectively 1.567um, 1.608um, 1.653um, 1.530um, 1.623um near-infrared band fiber-coupled distributed feedback laser (DFB) as the light source, Combined wavelength modulation spectroscopy and harmonic detection technique, developed a fiber-coupled white-type long-path gas absorption cell, to achieve high sensitivity detection of gas concentration. The system achieved a remote on-line monitoring of multi-component gas concentration,to meet the fire forecast need for Coal goaf area. There are obvious advantages Compared with the existing beam tube monitoring system in coal mine.

  8. The paradoxical role of urinary macromolecules in the aggregation of calcium oxalate: a further plea to increase diuresis in stone metaphylaxis.

    PubMed

    Baumann, J M; Affolter, B

    2016-08-01

    This study was designed to get information on aggregation (AGN) of urinary calcium oxalate crystals (CaOx) which seems to occur in stone formation despite a protecting coat of urinary macromolecules (UMs). CaOx crystallization was directly produced in urine, control and albumin solution by Ox titration and was spectrophotometrically followed. A rapid decrease of optical density indicating AGN was absent in 14 of 15 freshly voided urines of 5 healthy controls. However, in the presence of UM-coated hydroxyapatite all urines with relative high sodium concentration, being an indicator of concentrated urine, showed a pronounced AGN which was abolished when these urines were diluted. Albumin relatively found to be an inhibitor of AGN showed after temporary adsorption on Ca Phosphate (CaP) massive self-AGN and changed to a promoter of CaOx AGN. Self-AGN after adsorption on surfaces especially of CaP, being an important compound of Randall's plaques, can thus explain this paradoxical behavior of UMs. Aggregated UMs probably bridge zones of electrostatic repulsion between UM-coated crystals with identical electrical surface charge. These zones extend by urine dilution which decreases ionic strength. Diminution of urinary concentration by increasing diuresis seems, therefore, to be important in stone metaphylaxis. PMID:26920852

  9. Single spots, unipolar magnetic regions, and pairs of spots: 2. The development of sunspot pairs and the Hale boundary

    NASA Astrophysics Data System (ADS)

    Akasofu, Syun-Ichi

    2015-04-01

    Sunspot pairs develop in connection with cell networks at or near the boundaries of positive and negative unipolar magnetic (UM) field regions. In this paper, we confirm his findings by recent data. In this connection, Svalgaard and Wilcox (1976) found also that solar activities occur only at one side of UM boundaries, called the "Hale boundary," on the basis of their observation of the interplanetary magnetic field. It is shown in this paper that the Hale boundary can be recognized also on the photosphere. Further, it is shown that new UM regions grow at the beginning of a new sunspot cycle, and active regions and sunspot pairs tend to develop at or near newly developing Hale boundaries. Thus, it is suggested that UM regions and specifically Hale boundaries are very important for the formation of active regions, sunspots, and sunspot pairs. These facts suggest also that UM regions are not merely remnants of decaying old spots and active regions. Some of the essential features of sunspot pairs, as well as their relationship to the Hale boundary in both even and odd cycles are presented in one figure, illustrating several requirements for a theory of the formation of single spots and sunspot pairs.

  10. Uveal melanoma as a target for immune-therapy.

    PubMed

    Oliva, Marc; Rullan, Antonio J; Piulats, Josep M

    2016-05-01

    Uveal melanoma (UM) is a rare disease that can be deadly in spite of adequate local treatment. Systemic therapy with chemotherapy is usually ineffective and new-targeted therapies have not improved results considerably. The eye creates an immunosuppressive environment in order to protect eyesight. UM cells use similar processes to escape immune surveillance. Regarding innate immunity the production of macrophage inhibiting factor (MIF) and TGF-β, added to MHC class I upregulation, inhibits the action of natural killer (NK) cells. UM cells produce cytokines such as IL-6 and IL-10 that favor macrophage differentiation to the M2 subtype, which promote tumor growth instead of an effective immune response. UM cells also impair the adaptive immune response through production of indoleamine 2,3-dioxygenase (IDO), overexpression of programmed death ligand-1 (PD-L1), alteration of FasL expression, and resistance to perforin. This biological background suggests that immunotherapy could be effective in fighting UM. A Phase II clinical trial with Ipilimumab has shown promising results with mean Overall Survival rate of ten months, and close to 50% of the patients alive at one year. Clinical trials with anti-PD1 antibodies in monotherapy and in combination with anti-CTLA4 are currently recruiting patients worldwide. PMID:27275485

  11. Uveal melanoma as a target for immune-therapy

    PubMed Central

    Oliva, Marc; Rullan, Antonio J.

    2016-01-01

    Uveal melanoma (UM) is a rare disease that can be deadly in spite of adequate local treatment. Systemic therapy with chemotherapy is usually ineffective and new-targeted therapies have not improved results considerably. The eye creates an immunosuppressive environment in order to protect eyesight. UM cells use similar processes to escape immune surveillance. Regarding innate immunity the production of macrophage inhibiting factor (MIF) and TGF-β, added to MHC class I upregulation, inhibits the action of natural killer (NK) cells. UM cells produce cytokines such as IL-6 and IL-10 that favor macrophage differentiation to the M2 subtype, which promote tumor growth instead of an effective immune response. UM cells also impair the adaptive immune response through production of indoleamine 2,3-dioxygenase (IDO), overexpression of programmed death ligand-1 (PD-L1), alteration of FasL expression, and resistance to perforin. This biological background suggests that immunotherapy could be effective in fighting UM. A Phase II clinical trial with Ipilimumab has shown promising results with mean Overall Survival rate of ten months, and close to 50% of the patients alive at one year. Clinical trials with anti-PD1 antibodies in monotherapy and in combination with anti-CTLA4 are currently recruiting patients worldwide. PMID:27275485

  12. Analytical estimate of phase mixing time of longitudinal Akhiezer-Polovin waves

    NASA Astrophysics Data System (ADS)

    Mukherjee, Arghya; Sengupta, Sudip

    2014-11-01

    Phase mixing of a longitudinal Akhiezer-Polovin wave subjected to a small amplitude longitudinal perturbation and its eventual breaking is studied analytically. It is well known that longitudinal Akhiezer-Polovin wave subjected to arbitrarily small longitudinal perturbation breaks via the process of phase mixing at an amplitude well below its limiting amplitude [Verma et al., Phys. Rev. Lett. 108, 125005 (2012)]. We analytically show that the phase mixing time (breaking time, ωpτmix) scales with β (phase velocity) and um(maximum fluid velocity) as ωpτmi x˜2/πβ 3 δ [1 /um2-1 /4 ] , where δ is the amplitude of velocity perturbation and ωp is the non-relativistic plasma frequency. This analytical dependence of phase mixing time on β, um, and δ is further verified using numerical simulations based on Dawson sheet model.

  13. Photoluminescence Imaging of Large-Grain CdTe for Grain Boundary Characterization

    SciTech Connect

    Johnston, Steve; Allende Motz, Alyssa; Reese, Matthew O.; Burst, James M.; Metzger, Wyatt K.

    2015-06-14

    In this work, we use photoluminescence (PL) imaging to characterize CdTe grain boundary recombination. We use a silicon megapixel camera and green (532 nm) laser diodes for excitation. A microscope objective lens system is used for high spatial resolution and a field of view down to 190 um x 190 um. PL images of large-grain (5 to 50 um) CdTe samples show grain boundary and grain interior features that vary with processing conditions. PL images of samples in the as-deposited state show distinct dark grain boundaries that suggest high excess carrier recombination. A CdCl2 treatment leads to PL images with very little distinction at the grain boundaries, which illustrates the grain boundary passivation properties. Other process conditions are also shown, along with comparisons of PL images to high spatial resolution time-resolved PL carrier lifetime maps.

  14. VizieR Online Data Catalog: JCMT Gould Belt Survey: Serpens MWC 297 (Rumble+, 2015)

    NASA Astrophysics Data System (ADS)

    Rumble, D.; Hatchell, J.; Gutermuth, R. A.; Kirk, H.; Buckle, J.; Beaulieu, S. F.; Berry, D. S.; Broekhoven-Fiene, H.; Currie, M. J.; Fich, M.; Jenness, T.; Johnstone, D.; Mottram, J. C.; Nutter, D.; Pattle, K.; Pineda, J. E.; Quinn, C.; Salji, C.; Tisi, S.; Walker-Smith, S.; Di, Francesco J.; Hogerheijde, M. R.; Ward-thompson, D.; Allen, L. E.; Cieza, L. A.; Dunham, M. M.; Harvey, P. M.; Stapelfeldt, K. R.; Bastien, P.; Butner, H.; Chen, M.; Chrysostomou, A.; Coude, S.; Davis, C. J.; Drabek-Maunder, E.; Duarte-Cabral, A.; Fiege, J.; Friberg, P.; Friesen, R.; Fuller, G. A.; Graves, S.; Greaves, J.; Gregson, J.; Holland, W.; Joncas, G.; Kirk, J. M.; Knee, L. B. G.; Mairs, S.; Marsh, K.; Matthews, B. C.; Moriarty-Schieven, G.; Rawlings, J.; Richer, J.; Robertson, D.; Rosolowsky, E.; Sadavoy, S.; Thomas, H.; Tothill, N.; Viti, S.; White, G. J.; Wilson, C. D.; Wouterloot, J.; Yates, J.; Zhu, M.

    2015-09-01

    Serpens MWC 297 was observed with SCUBA-2 on the 2012 July 5 and 8 as part of the JCMT GBS MJLSG33 SCUBA-2 Serpens Campaign. Continuum observations at 850 and 450um were made using fully sampled 30 arcmin diameter circular regions centered on RA=18:28:13.8, DE=-03:44:01.7 (J2000). The MWC 297 region was observed twice by Spitzer in the mid-infrared, first as part of the Spitzer Young Clusters Survey (SYC; Gutermuth et al., 2009, Cat. J/ApJS/184/18) and secondly as part of the Spitzer legacy programme 'Gould's Belt: star formation in the solar neighbourhood' (SGBS, PID: 30574). In both surveys, mapping observations were taken at 3.6, 4.5, 5.8 and 8.0um with the Infrared Array Camera (IRAC) and at 24um with the Multiband Imaging Photometer for Spitzer (MIPS). (3 data files).

  15. Study of relationships of material properties and high efficiency solar cell performance on material composition

    NASA Astrophysics Data System (ADS)

    Sah, C. T.

    1983-07-01

    The performance improvements obtainable from extending the traditionally thin back-surface-field (BSF) layer deep into the base of silicon solar cells under terrestrial solar illumination (AM1) are analyzed. This extended BSF cell is also known as the back-drift-field cell. About 100 silicon cells were analyzed, each with a different emitter or base dopant impurity distribution whose selection was based on physically anticipated improvements. The four principal performance parameters (the open-circuit voltage, the short-circuit current, the fill factor, and the maximum efficiency) are computed using a FORTRAN program, called Circuit Technique for Semiconductor-device Analysis, CTSA, which numerically solves the six Shockley Equations under AM1 solar illumination at 88.92 mW/cm, at an optimum cell thickness of 50 um. The results show that very significant performance improvements can be realized by extending the BSF layer thickness from 2 um (18% efficiency) to 40 um (20% efficiency).

  16. Isolation and characterization of sulfite oxidase from Alligator mississipiensis

    SciTech Connect

    Robbins, A.; Neame, P.J.; Barber, M.J. )

    1991-03-11

    Sulfite oxidase has been isolated from fresh alligator liver using ammonium sulfate and acetone fractionation, DEAE chromatography and FPLC on Mono Q. The enzyme is dimeric and exhibits a subunit M. Wt. of approximately 58 kDa, larger than that of chicken SO. EPR spectroscopy of the partially-reduced enzyme revealed a single Mo(V) species while visible spectroscopy revealed the presence of cytochrome b{sub 557}. Maximal activities were obtained at pH 8 and 9, respectively. K{sub m}'s for SO{sub 3}{sup 2 {minus}}, cyt. c and Fe(CN){sub 6}{sup 3 {minus}} were 23.5 uM, 2.9 uM and 8.0 uM, respectively. Sequencing of peptides obtained by endoprotease K digestion indicated regions of extensive sequence similarity to chicken and rat enzymes in both heme and Mo-pterin domains. Regions of sequence dissimilarity were also found.

  17. VizieR Online Data Catalog: The Red MSX Source Survey: massive protostars (Lumsden+, 2013)

    NASA Astrophysics Data System (ADS)

    Lumsden, S. L.; Hoare, M. G.; Urquhart, J. S.; Oudmaijer, R. D.; Davies, B.; Mottram, J. C.; Cooper, H. D. B.; Moore, T. J. T.

    2013-10-01

    The Midcourse Space Experiment (MSX) satellite mission included an astronomy experiment (SPIRIT III) designed to acquire mid-infrared photometry of sources in the Galactic plane (b<5°). MSX had a raw resolution of 18.3", a beam size 50 times smaller than that of IRAS at 12 and 25um. MSX observed six bands between 4 and 21um, of which the four between 8 and 21um are sensitive to astronomical sources. We used v2.3 of the MSX PSC (Egan et al. 2003, Cat. V/114) as our basic input, restricting ourselves to the main Galactic plane catalog, which excludes sources seen in only a single observing pass and those seen in multiple passes but with low significance. We restricted our catalog to 10

  18. Laser Heating of Solid Matter by Light-Pressure-Driven Shocks at Ultrarelativistic Intensities

    SciTech Connect

    Akli, K.U.; Hansen, S.B.; Kemp, A.J.; Freeman, R.R.; Beg, F.N.; Clark, D.C.; Chen, S.D.; Hey, D.; Hatchett, S.P.; Highbarger, K.; Giraldez, E.; Green, J.S.; Gregori, G.; Lancaster, K.L.; Ma, T.; MacKinnon, A.J.; Norreys, P.; Patel, N.; Pasley, J.; Shearer, C.; Stephens, R.B.; Stoeckl, C.; Storm, M.; Theobald, W.; Van Woerkom, L.D.; Weber, R.; Key, M.H.

    2008-04-29

    The heating of solid targets irradiated by 5 x 10^20 W cm^-2, 0.8 ps, 1.05 um wavelength laser light is studied by x-ray spectroscopy of the K-shell emission from thin layers of Ni, Mo, and V. A surface layer is heated to ~5 keV with an axial temperature gradient of 0.6 um scale length. Images of Ni Ly sub-alpha show the hot region has <25 um diameter. These data are consistent with collisional particle-in-cell simulations using preformed plasma density profiles from hydrodynamic modeling which show that the >100 Gbar light pressure compresses the preformed plasma and dries a shock into the solid, heating a thin layer.

  19. Extremely low NA Yb doped preforms (<0.03) fabricated by MCVD

    NASA Astrophysics Data System (ADS)

    Petit, Vincent; Tumminelli, Richard P.; Minelly, John D.; Khitrov, Victor

    2016-03-01

    We report the fabrication of extremely low NA preforms (<0.03), highly doped with Yb using a conventional Modified Chemical Vapor Deposition (MCVD) system. Our lowest NA preform (0.025 NA) was drawn to a 52um core step-index double-clad fiber operating in a single mode regime (M2=1.04). The fiber had a mode field diameter (MFD) and an effective area (Aeff) greater than 35um and 1000um2 respectively. In a fiber laser configuration, the efficiency was greater than 85% without any sign of photodarkening. To the best of our knowledge, by using our extremely low NA preforms we have demonstrated the largest MFD and Aeff to date for a single-mode step index double-clad Yb doped fiber without involving any micro-structuration.

  20. VizieR Online Data Catalog: 20cm survey of the AKARI SEP (ATCA-ADFS) (White+, 2012)

    NASA Astrophysics Data System (ADS)

    White, G. J.; Hatsukade, B.; Pearson, C.; Takagi, T.; Sedgwick, C.; Matsuura, S.; Matsuhara, H.; Serjeant, S.; Nakagawa, T.; Lee, H. M.; Oyabu, S.; Jeong, W.-S.; Shirahata, M.; Kohno, K.; Yamamura, I.; Hanami, H.; Goto, T.; Makiuti, S.; Clements, D. L.; Malek, K.; Khan, S. A.

    2013-08-01

    The AKARI ADF-S survey was primarily made in the far-infrared at wavelengths of 65, 90, 140, 160um over a 12deg2 area with the AKARI Far-Infrared Surveyor (FIS) instrument, with shallower mid-infrared coverage at 9, 18um using the AKARI Infrared Camera (IRC) instrument. In addition to the wide survey, deeper mid-infrared pointed observations, using the IRC, covering ~0.8deg2 and reaching 5σ sensitivities of 16, 16, 74, 132, 280 and 580uJy at 3.2, 4.6, 7, 11, 15, 24um were also carried out. The radio observations were collected over a 13d period in 2007 July using the ATCA operated at 1.344 and 1.432GHz. (1 data file).

  1. A novel bistable thermally actuated snap-through actuator for out-of-plane deflection

    NASA Astrophysics Data System (ADS)

    Yu, Kevin; Michael, Aron; Kwok, Chee Y.

    2004-04-01

    In this paper , the importance of boundary conditions for two- way bistable thermal snapping action is analysed by Ansys simulations. Several designs are developed and modified into a novel bistable actuator for out of plane deflection. It consists of 4 long epi-silicon single layered legs , a 1200um x 40um x 3um microbeam and 4 spring-supports in which both are polysilicon/oxide/episilicon layered. Buckling of the released structure is achieved by the compressive residual stress remaining in the oxide layer as a result of the processing. The structure switches between two stable equilibrium states by heating the legs and then heating one of the polysilicon layers to produce the thermal moment needed for snapping to occur, hence achieving two-way bistable operation.

  2. Compositional shift in lipid fractions during lipid accumulation and turnover in Schizochytrium sp.

    PubMed

    Ren, Lu-Jing; Sun, Guan-Nan; Ji, Xiao-Jun; Hu, Xue-Chao; Huang, He

    2014-04-01

    Single cell oils (SCOs), a complex lipid system, contains neutral lipids (NLs), polar lipids (PLs) and unsaponifiable matters (UMs). To investigate the dynamic changes and the metabolic competition mechanism of different components of SCOs, changes in lipid composition of Schizochytrium sp. were monitored in lipid accumulation and turnover stages. Lipid content could reach 69.98% in biomass during the lipid accumulation stage, while, after the exhaustion of glucose, the content decreased to 45.51% and 20.6g/L non-oil biomass was synthesis. Polyunsaturated fatty acids (PUFAs) were easier to bind with PLs. NLs were preferentially converted to PLs during lipid turnover stage, accompanied by the degradation of saturated fatty acids and the increase of UMs. Meanwhile, a positive correlation between the synthesis of PUFAs and unsaponifiable matters exited in Schizochytrium sp., and increasing the content of UMs from 45 to 100mg/L could increase the PUFA percentage from 64% to 74% effectively. PMID:24534791

  3. Comparative Genomic Analysis Reveals a Possible Novel Non-Tuberculous Mycobacterium Species with High Pathogenic Potential

    PubMed Central

    Choo, Siew Woh; Dutta, Avirup; Wong, Guat Jah; Wee, Wei Yee; Ang, Mia Yang; Siow, Cheuk Chuen

    2016-01-01

    Mycobacteria have been reported to cause a wide range of human diseases. We present the first whole-genome study of a Non-Tuberculous Mycobacterium, Mycobacterium sp. UM_CSW (referred to hereafter as UM_CSW), isolated from a patient diagnosed with bronchiectasis. Our data suggest that this clinical isolate is likely a novel mycobacterial species, supported by clear evidence from molecular phylogenetic, comparative genomic, ANI and AAI analyses. UM_CSW is closely related to the Mycobacterium avium complex. While it has characteristic features of an environmental bacterium, it also shows a high pathogenic potential with the presence of a wide variety of putative genes related to bacterial virulence and shares very similar pathogenomic profiles with the known pathogenic mycobacterial species. Thus, we conclude that this possible novel Mycobacterium species should be tightly monitored for its possible causative role in human infections. PMID:27035710

  4. Genetic deletion and pharmacological inhibition of Akt1 isoform attenuates bladder cancer cell proliferation, motility and invasion.

    PubMed

    Sabbineni, Harika; Alwhaibi, Abdulrahman; Goc, Anna; Gao, Fei; Pruitt, Alanna; Somanath, Payaningal R

    2015-10-01

    Isoform specific expression, intracellular localization and function of Akt in bladder cancer are not known. In the current study, we identified Akt1, followed by Akt2 and Akt3 as the predominant Akt isoform in human T24 and UM-UC-3 metastatic bladder cancer cells. Whereas Akt1 is localized at the membrane, cytoplasm and nucleus, Akt2 is solely cytoplasmic and Akt3 is mostly localized in the nucleus in T24 cells. ShRNA-mediated Akt1 knockdown resulted in impaired T24 cell survival, proliferation, colony formation, migration and microinvasion. Whereas pharmacological inhibition of Akt1 resulted in impaired T24 and UM-UC-3 cell motility, viability and proliferation, effect of pharmacological inhibition by Akt2 inhibitor was limited to proliferation in T24, but not UM-UC-3 cells. Our data provide important clues on the therapeutic benefits of targeting Akt1 for bladder cancer therapy. PMID:26148825

  5. Printed Module Interconnects

    SciTech Connect

    Stockert, Talysa R.; Fields, Jeremy D.; Pach, Gregory F.; Mauger, Scott A.; van Hest, Maikel F. A. M.

    2015-06-14

    Monolithic interconnects in photovoltaic modules connect adjacent cells in series, and are typically formed sequentially involving multiple deposition and scribing steps. Interconnect widths of 500 um every 10 mm result in 5% dead area, which does not contribute to power generation in an interconnected solar panel. This work expands on previous work that introduced an alternative interconnection method capable of producing interconnect widths less than 100 um. The interconnect is added to the module in a single step after deposition of the photovoltaic stack, eliminating the need for scribe alignment. This alternative method can be used for all types of thin film photovoltaic modules. Voltage addition with copper-indium-gallium-diselenide (CIGS) solar cells using a 2-scribe printed interconnect approach is demonstrated. Additionally, interconnect widths of 250 um are shown.

  6. Stitched large format CMOS image sensors for dental x-ray digital radiography

    NASA Astrophysics Data System (ADS)

    Liu, Xinqiao (Chiao); Fowler, Boyd; Do, Hung; Jaffe, Mark; Rassel, Richard; Leidy, Bob

    2012-10-01

    In this paper, we present a family of large format CIS's designed for dental x-ray applications. The CIS areas vary from small 31.5mm x 20.1mm, to medium 34.1mm x 26.3mm, to large 37.1mm x 26.3mm. Pixel size is 19.5um x 19.5um. The sensor family was fabricated in a 0.18um CIS process. Stitching is used in the CIS fabrication for the medium and large size sensors. We present the CIS and detector system design that includes pixel circuitry, readout circuitry, x-ray trigger mechanism, scintillator, and the camera electronics. We also present characterization results including the detector performances under both visible light and x-ray radiation.

  7. CMOS digital intra-oral sensor for x-ray radiography

    NASA Astrophysics Data System (ADS)

    Liu, Xinqiao; Byczko, Andrew; Choi, Marcus; Chung, Lap; Do, Hung; Fowler, Boyd; Ispasoiu, Radu; Joshi, Kumar; Miller, Todd; Nagy, Alex; Reaves, David; Rodricks, Brian; Teeter, Doug; Wang, George; Xiao, Feng

    2011-03-01

    In this paper, we present a CMOS digital intra-oral sensor for x-ray radiography. The sensor system consists of a custom CMOS imager, custom scintillator/fiber optics plate, camera timing and digital control electronics, and direct USB communication. The CMOS imager contains 1700 x 1346 pixels. The pixel size is 19.5um x 19.5um. The imager was fabricated with a 0.18um CMOS imaging process. The sensor and CMOS imager design features chamfered corners for patient comfort. All camera functions were integrated within the sensor housing and a standard USB cable was used to directly connect the intra-oral sensor to the host computer. The sensor demonstrated wide dynamic range from 5uGy to 1300uGy and high image quality with a SNR of greater than 160 at 400uGy dose. The sensor has a spatial resolution more than 20 lp/mm.

  8. Study of relationships of material properties and high efficiency solar cell performance on material composition

    NASA Technical Reports Server (NTRS)

    Sah, C. T.

    1983-01-01

    The performance improvements obtainable from extending the traditionally thin back-surface-field (BSF) layer deep into the base of silicon solar cells under terrestrial solar illumination (AM1) are analyzed. This extended BSF cell is also known as the back-drift-field cell. About 100 silicon cells were analyzed, each with a different emitter or base dopant impurity distribution whose selection was based on physically anticipated improvements. The four principal performance parameters (the open-circuit voltage, the short-circuit current, the fill factor, and the maximum efficiency) are computed using a FORTRAN program, called Circuit Technique for Semiconductor-device Analysis, CTSA, which numerically solves the six Shockley Equations under AM1 solar illumination at 88.92 mW/cm, at an optimum cell thickness of 50 um. The results show that very significant performance improvements can be realized by extending the BSF layer thickness from 2 um (18% efficiency) to 40 um (20% efficiency).

  9. Investigation of Electron Transfer-Based Photonic and Electro-Optic Materials and Devices

    SciTech Connect

    Bromenshenk, Jerry J; Abbott, Edwin H; Dickensheets, David; Donovan, Richard P; Hobbs, J D; Spangler, Lee; McGuirl, Michele A; Spangler, Charles; Rebane, Aleksander; Rosenburg, Edward; Schmidt, V H; Singel, David J

    2008-03-28

    Montana's state program began its sixth year in 2006. The project's research cluster focused on physical, chemical, and biological materials that exhibit unique electron-transfer properties. Our investigators have filed several patents and have also have established five spin-off businesses (3 MSU, 2 UM) and a research center (MT Tech). In addition, this project involved faculty and students at three campuses (MSU, UM, MT Tech) and has a number of under-represented students, including 10 women and 5 Native Americans. In 2006, there was an added emphasis on exporting seminars and speakers via the Internet from UM to Chief Dull Knife Community College, as well as work with the MT Department of Commerce to better educate our faculty regarding establishing small businesses, licensing and patent issues, and SBIR program opportunities.

  10. Final Technical Report for University of Michigan Industrial Assessment Center

    SciTech Connect

    Atreya, Arvind

    2007-04-17

    The UM Industrial Assessment Center assisted 119 primary metals, automotive parts, metal casting, chemicals, forest products, agricultural, and glass manufacturers in Michigan, Ohio and Indiana to become more productive and profitable by identifying and recommending specific measures to improve energy efficiency, reduce waste and increase productivity. This directly benefits the environment by saving a total of 309,194 MMBtu of energy resulting in reduction of 0.004 metric tons of carbon emissions. The $4,618,740 implemented cost savings generated also saves jobs that are evaporating from the manufacturing industries in the US. Most importantly, the UM Industrial Assessment Center provided extremely valuable energy education to forty one UM graduate and undergraduate students. The practical experience complements their classroom education. This also has a large multiplier effect because the students take the knowledge and training with them.

  11. Inhibition of the effects of thrombin on guinea pig platelets by the diacylglycerol lipase inhibitor RHC 80267

    SciTech Connect

    Amin, D.; Sutherland, C.A.; Khandwala, A.S.; Jamall, I.S.; Kapoor, A.L.

    1986-10-01

    Phospholipase C (PLC) and diacylglycerol lipase (DGL) activities were found in guinea pig platelet microsome preparations. No phospholipase A2 (PLA2) activity was detected. RHC 80267 (1,6-di (0-(carbamoyl) cyclohexanone oxime)hexane) inhibited DGL activity (IC50 = 4 uM) from guinea pig platelet microsomes but had no effect on PLC. RHC 80267 inhibited platelet aggregation (IC50 = 11 uM), release of arachidonic acid (AA), its metabolites, and ATP (IC50 = 4.5 uM) when guinea pig platelets were challenged with a low concentration of thrombin. We propose that PLC-DGL is an important enzymatic pathway for the release of AA in guinea pig platelets.

  12. Characterization of NIR InGaAs imager arrays for the JDEM SNAPmission concept

    SciTech Connect

    Seshadri, S.; Cole, M.D.; Hancock, B.; Ringold, P.; Wrigley, C.; Bonati, M.; Brown, M.G.; Schubnell, M.; Rahmer, G.; Guzman, D.; Figer,D.; Tarle, G.; Smith, R.M.; Bebek, C.

    2006-05-23

    We present the results of a study of the performance of InGaAs detectors conducted for the SuperNova Acceleration Probe (SNAP) dark energy mission concept. Low temperature data from a nominal 1.7um cut-off wavelength 1kx1k InGaAs photodiode array, hybridized to a Rockwell H1RG multiplexer suggest that InGaAs detector performance is comparable to those of existing 1.7um cut-off HgCdTe arrays. Advances in 1.7um HgCdTe dark current and noise initiated by the SNAP detector research and development program makes it the baseline detector technology for SNAP. However, the results presented herein suggest that existing InGaAs technology is a suitable alternative for other future astronomy applications.

  13. Evaluation of Laser Stabilization and Imaging Systems for LCLS-II - Final Paper

    SciTech Connect

    Barry, Matthew

    2015-08-20

    By combining the top performing commercial laser beam stabilization system with the most ideal optical imaging configuration, the beamline for the Linear Accelerator Coherent Light Source II (LCLS-II) will deliver the highest quality and most stable beam to the cathode. To determine the optimal combination, LCLS-II beamline conditions were replicated and the systems tested with a He-Ne laser. The Guidestar-II and MRC active laser beam stabilization systems were evaluated for their ideal positioning and stability. Both a two and four lens optical imaging configuration was then evaluated for beam imaging quality, magnification properties, and natural stability. In their best performances when tested over fifteen hours, Guidestar-II kept the beam stable over approximately 70-110um while the MRC system kept it stable over approximately 90-100um. During short periods of time, Guidestar-II kept the beam stable between 10-20um, but was more susceptible to drift over time, while the MRC system maintained the beam between 30-50um with less overall drift. The best optical imaging configuration proved to be a four lens system that images to the iris located in the cathode room and from there, imaged to the cathode. The magnification from the iris to the cathode was 2:1, within an acceptable tolerance to the expected 2.1:1 magnification. The two lens configuration was slightly more stable in small periods of time (less than 10 minutes) without the assistance of a stability system, approximately 55um compared to approximately 70um, but the four lens configurations beam image had a significantly flatter intensity distribution compared to the two lens configuration which had a Gaussian distribution. A final test still needs to be run with both stability systems running at the same time through the four lens system. With this data, the optimal laser beam stabilization system can be determined for the beamline of LCLS-II.

  14. Endothelial derived factors inhibit anoikis of head and neck cancer stem cells

    PubMed Central

    Campos, Marcia S.; Neiva, Kathleen G.; Meyers, Kristy A.; Krishnamurthy, Sudha; Nör, Jacques E.

    2011-01-01

    Recent evidence demonstrated that cancer stem cells reside in close proximity to blood vessels in human head and neck squamous cell carcinomas (HNSCC). These findings suggest the existence of a supporting perivascular niche for cancer stem cells. Objective The purpose of this study was to evaluate the effect of endothelial cell-secreted factors on the behavior of head and neck cancer stem-like cells (HNCSC). Materials and methods HNCSC were identified by sorting UM-SCC-22A (cell line derived from a primary squamous cell carcinoma of the oropharynx) and UM-SCC-22B (derived from the metastatic lymph node of the same patient) for CD44 expression and ALDH (aldehyde dehydrogenase) activity. HNCSC (ALDH+CD44+) and control (ALDH−CD44−) cells were cultured in ultra-low attachment plates in presence of conditioned medium from primary human endothelial cells. Results ALDH+CD44+ generated more orospheres than control cells when cultured in suspension. The growth factor milieu secreted by endothelial cells protected HNCSC against anoikis. Mechanistic studies revealed that endothelial cell-secreted vascular endothelial growth factor (VEGF) induces proliferation of HNCSC derived from primary UM-SCC-22A, but not from the metastatic UM-SCC-22B. Likewise, blockade of VEGF abrogated endothelial cell-induced Akt phosphorylation in HNCSC derived from UM-SCC-22A while it had a modest effect in Akt phosphorylation in HNCSC from UM-SCC-22B. Conclusion This study revealed that endothelial cells initiate a crosstalk that protect head and neck cancer stem cells against anoikis, and suggest that therapeutic interference with this crosstalk might be beneficial for patients with head and neck cancer. PMID:22014666

  15. "INDEPENDENT CONFIRMATORY SURVEY SUMMARY AND RESULTS FOR THE FORD NUCLEAR REACTOR, REVISION 1, ANN ARBOR, MICHIGAN

    SciTech Connect

    ALTIC, NICK A

    2013-08-01

    At the NRC's request, ORAU conducted confirmatory surveys of the FNR during the period of December 4 through 6, 2012. The survey activities included visual inspections and measurement and sampling activities. Confirmatory activities also included the review and assessment of UM's project documentation and methodologies. Surface scans identified elevated activity in two areas. The first area was on a wall outside of Room 3103 and the second area was in the southwest section on the first floor. The first area was remediated to background levels. However, the second area was due to gamma shine from a neighboring source storage area. A retrospective analysis of UM's FSS data shows that for the SUs investigated by the ORAU survey team, UM met the survey requirements set forth in the FSSP. The total mean surface activity values were directly compared with the mean total surface activity reported by UM. Mean surface activity values determined by UM were within two standard deviations of the mean determined by ORAU. Additionally, all surface activity values were less than the corresponding gross beta DCGL{sub W}. Laboratory analysis of the soil showed that COC concentrations were less than the respective DCGL{sub W} values. For the inter-lab comparison, the DER was above 3 for only one sample. However, since the sum of fractions for each of the soil samples was below 1, thus none of the samples would fail to meet release guidelines. Based on the findings of the side-by-side direct measurements, and after discussion with the NRC and ORAU, UM decided to use a more appropriate source efficiency in their direct measurement calculations and changed their source efficiency from 0.37 to 0.25.

  16. INDEPENDENT CONFIRMATORY SURVEY SUMMARY AND RESULTS FOR THE FORD NUCLEAR REACTOR, ANN ARBOR, MICHIGAN

    SciTech Connect

    ALTIC, NICK A

    2013-07-25

    At the NRC's request, ORAU conducted confirmatory surveys of the FNR during the period of December 4 through 6, 2012. The survey activities included visual inspections and measurement and sampling activities. Confirmatory activities also included the review and assessment of UM's project documentation and methodologies. Surface scans identified elevated activity in two areas. The first area was on a wall outside of Room 3103 and the second area was in the southwest section on the first floor. The first area was remediated to background levels. However, the second area was due to gamma shine from a neighboring source storage area. A retrospective analysis of UM's FSS data shows that for the SUs investigated by the ORAU survey team, UM met the survey requirements set forth in the FSSP. The total mean surface activity values were directly compared with the mean total surface activity reported by UM. Mean surface activity values determined by UM were within two standard deviations of the mean determined by ORAU. Additionally, all surface activity values were less than the corresponding gross beta DCGLW. Laboratory analysis of the soil showed that COC concentrations were less than the respective DCGLW values. For the inter-lab comparison, the DER was above 3 for only one sample. However, since the sum of fractions for each of the soil samples was below 1, thus none of the samples would fail to meet release guidelines. Based on the findings of the side-by-side direct measurements, and after discussion with the NRC and ORAU, UM decided to use a more appropriate source efficiency in their direct measurement calculations and changed their source efficiency from 0.37 to 0.25.

  17. Delivering informatics capabilities to an AHC research community through public/private partnerships (PPP).

    PubMed

    Smith, Kevin A; Athey, Brian D; Chahal, Amar P S; Sahai, Priti

    2008-01-01

    Velos eResearch is a commercially-developed, regulatory-compliant, web-based clinical research information system from Velos Inc. Aithent Inc. is a software development services company. The University of Michigan (UM) has public/private partnerships with Velos and Aithent to collaborate on development of additional capabilities, modules, and new products to better support the needs of clinical and translational research communities. These partnerships provide UM with a mechanism for obtaining high-quality functionally comprehensive capabilities more quickly and at lower cost, while the corporate partners get a quality advisory and development partner--this benefits all parties. The UM chose to partner with Velos in part because of its commitment to interoperability. Velos is an active participant in the NCI caBIG project and is committed to caBIG compatibility. Velos already provides interoperability with other Velos sites in the CTSA context. One example of the partnership is co-development of integrated specimen management capabilities. UM spent more than a year defining business requirements and technical specifications for, and is funding development of, this capability. UM also facilitates an autonomous user community (20+ institutions, 7 CTSA awardees); the broad goal of the group is to share experiences, expertise, identify collaborative opportunities, and support one another as well as provide a source of future needs identification to Velos. Advantages and risks related to delivering informatics capabilities to an AHC research community through a public/private partnership will be presented. The UM, Velos and Aithent will discuss frameworks, agreements and other factors that have contributed to a successful partnership. PMID:18999086

  18. University of Malaya dental students' attitudes towards communication skills learning: implications for dental education.

    PubMed

    Nor, Nor Azlida M; Yusof, Zamros Y M; Shahidan, Mohd Noor F M

    2011-12-01

    The Ministry of Higher Education in Malaysia has called for the implementation of a soft skills module in all public universities in Malaysia. In response to this and as part of curriculum development efforts for a new integrated program for 2011, a study was undertaken to improve the University of Malaya (UM) Faculty of Dentistry's communication skills course. One of the study objectives was to investigate dental students' attitudes towards communication skills learning and the association between their attitudes and demographic and education-related characteristics. A cross-sectional survey--using a self-administered twenty-four-item adapted Communication Skills Attitude Scale (CSAS) that contained both positive (PAS) and negative (NAS) attitude subscales--was carried out targeting all final-year dental students at the UM and the Universiti Kebangsaan Malaysia (UKM). A total of 148 students completed the survey, yielding a response rate of 88.1 percent. Overall, UKM students had significantly more positive attitudes towards communication skills learning (PAS score: mean=48.69, SD=4.48, p<0.001) than UM students (mean=46.03, SD=4.22). There was no statistically significant difference in negative attitudes between the two groups. UKM students with more positive attitudes tended to be female (p<0.05). UM students with more negative attitudes perceived themselves as poor communicators (p<0.05), and UKM students with more negative attitudes tended to have poor English proficiency (p<0.05). This study found that both UM and UKM final-year dental students have positive and negative attitudes towards learning communication skills. These attitudes were significantly associated with certain background and education-related attributes. Outcomes of this study served as a valuable guide in strengthening the communication skills course for the UM's new, integrated dental curriculum. PMID:22184601

  19. Patterns of morphological variation in enamel–dentin junction and outer enamel surface of human molars

    PubMed Central

    Morita, Wataru; Yano, Wataru; Nagaoka, Tomohito; Abe, Mikiko; Ohshima, Hayato; Nakatsukasa, Masato

    2014-01-01

    Tooth crown patterning is governed by the growth and folding of the inner enamel epithelium (IEE) and the following enamel deposition forms outer enamel surface (OES). We hypothesized that overall dental crown shape and covariation structure are determined by processes that configurate shape at the enamel–dentine junction (EDJ), the developmental vestige of IEE. This this hypothesis was tested by comparing patterns of morphological variation between EDJ and OES in human permanent maxillary first molar (UM1) and deciduous second molar (um2). Using geometric morphometric methods, we described morphological variation and covariation between EDJ and OES, and evaluated the strength of two components of phenotypic variability, canalization and morphological integration, in addition to the relevant evolutionary flexibility, i.e. the ability to respond to selective pressure. The strength of covariation between EDJ and OES was greater in um2 than in UM1, and the way that multiple traits covary between EDJ and OES was different between these teeth. The variability analyses showed that EDJ had less shape variation and a higher level of morphological integration than OES, which indicated that canalization and morphological integration acted as developmental constraints. These tendencies were greater in UM1 than in um2. On the other hand, EDJ and OES had a comparable level of evolvability in these teeth. Amelogenesis could play a significant role in tooth shape and covariation structure, and its influence was not constant among teeth, which may be responsible for the differences in the rate and/or period of enamel formation. PMID:24689536

  20. Prognostic value of legumain in uveal melanoma

    PubMed Central

    WU, TONG; SUN, LEI; WU, YING; XIANG, RONG; LI, YUWEI; RONG, WEINING; SUN, FENGYUAN; WANG, NINGLI

    2016-01-01

    The present study aimed to assess the expression of legumain in uveal melanoma (UM) cell lines and primary UM specimens, and to determine the possible association between legumain expression and clinical as well as pathological characteristics to reveal its impact on the prognosis of patients with UM. Records of primary UM cases treated at Beijing Tongren Hospital and Tianjin Eye Hospital between 1996 and 2005 were retrieved for analysis and a total of 82 patients with uveal melanoma were included in the study. The expression of legumain in the formalin-fixed and paraffin-embedded surgical specimens of these 82 patients was determined using immunohistochemical analysis. In addition, the expression of legumain was examined in two uveal melanoma cell lines using polymerase chain reaction and western blot analyses. The association of legumain expression with clinical/pathological characteristics was analyzed using the χ2 and Fisher's exact test. In addition, the impact of legumain on the prognosis of patients with uveal melanoma was examined. Upregulation of legumain was more predominant in the highly invasive uveal melanoma cell line MUM-2B compared with that in the MUM-2C with low invasiveness. Of 82 primary uveal melanoma tissues, 35 exhibited high expression of legumain, while the other 47 specimens exhibited low or negative expression of legumain. High legumain expression was primarily associated with local invasion of UM. Overall survival analysis revealed that the patients with high legumain expression exhibited poorer survival than patients with low/negative legumain expression. These findings suggested that upregulation of legumain is associated with malignant behavior of UM and that legumain may be used as an negative prognostic factor as well as a therapeutic target. PMID:26846877