CHARMM-GUI PDB manipulator for advanced modeling and simulations of proteins containing nonstandard residues.

PubMed

Jo, Sunhwan; Cheng, Xi; Islam, Shahidul M; Huang, Lei; Rui, Huan; Zhu, Allen; Lee, Hui Sun; Qi, Yifei; Han, Wei; Vanommeslaeghe, Kenno; MacKerell, Alexander D; Roux, Benoît; Im, Wonpil

2014-01-01

CHARMM-GUI, http://www.charmm-gui.org, is a web-based graphical user interface to prepare molecular simulation systems and input files to facilitate the usage of common and advanced simulation techniques. Since it is originally developed in 2006, CHARMM-GUI has been widely adopted for various purposes and now contains a number of different modules designed to setup a broad range of simulations including free energy calculation and large-scale coarse-grained representation. Here, we describe functionalities that have recently been integrated into CHARMM-GUI PDB Manipulator, such as ligand force field generation, incorporation of methanethiosulfonate spin labels and chemical modifiers, and substitution of amino acids with unnatural amino acids. These new features are expected to be useful in advanced biomolecular modeling and simulation of proteins. © 2014 Elsevier Inc. All rights reserved.

Advanced Docking System With Magnetic Initial Capture

NASA Technical Reports Server (NTRS)

Lewis, James L.; Carroll, Monty B.; Morales, Ray; Le, Thang

2004-01-01

An advanced docking system is undergoing development to enable softer, safer docking than was possible when using prior docking systems. This system is intended for original use in docking of visiting spacecraft and berthing the Crew Return Vehicle at the International Space Station (ISS). The system could also be adapted to a variety of other uses in outer space and on Earth, including mating submersible vehicles, assembling structures, and robotic berthing/handling of payloads and cargo. Heretofore, two large spacecraft have been docked by causing the spacecraft to approach each other at a speed sufficient to activate capture latches - a procedure that results in large docking loads and is made more difficult because of the speed. The basic design and mode of operation of the present advanced docking system would eliminate the need to rely on speed of approach to activate capture latches, thereby making it possible to reduce approach speed and thus docking loads substantially. The system would comprise an active subsystem on one spacecraft and a passive subsystem on another spacecraft with which the active subsystem will be docked. The passive subsystem would include an extensible ring containing magnetic striker plates and guide petals. The active subsystem would include mating guide petals and electromagnets containing limit switches and would be arranged to mate with the magnetic striker plates and guide petals of the passive assembly. The electromagnets would be carried on (but not rigidly attached to) a structural ring that would be instrumented with load sensors. The outputs of the sensors would be sent, along with position information, as feedback to an electronic control subsystem. The system would also include electromechanical actuators that would extend or retract the ring upon command by the control subsystem.

Advanced ultrasonic measurement methodology for non-invasive interrogation and identification of fluids in sealed containers

NASA Astrophysics Data System (ADS)

Tucker, Brian J.; Diaz, Aaron A.; Eckenrode, Brian A.

2006-03-01

Government agencies and homeland security related organizations have identified the need to develop and establish a wide range of unprecedented capabilities for providing scientific and technical forensic services to investigations involving hazardous chemical, biological, and radiological materials, including extremely dangerous chemical and biological warfare agents. Pacific Northwest National Laboratory (PNNL) has developed a prototype portable, hand-held, hazardous materials acoustic inspection prototype that provides noninvasive container interrogation and material identification capabilities using nondestructive ultrasonic velocity and attenuation measurements. Due to the wide variety of fluids as well as container sizes and materials encountered in various law enforcement inspection activities, the need for high measurement sensitivity and advanced ultrasonic measurement techniques were identified. The prototype was developed using a versatile electronics platform, advanced ultrasonic wave propagation methods, and advanced signal processing techniques. This paper primarily focuses on the ultrasonic measurement methods and signal processing techniques incorporated into the prototype. High bandwidth ultrasonic transducers combined with an advanced pulse compression technique allowed researchers to 1) obtain high signal-to-noise ratios and 2) obtain accurate and consistent time-of-flight (TOF) measurements through a variety of highly attenuative containers and fluid media. Results of work conducted in the laboratory have demonstrated that the prototype experimental measurement technique also provided information regarding container properties, which will be utilized in future container-independent measurements of hidden liquids.

Advanced extravehicular protective systems for shuttle, space station, lunar base and Mars missions.

NASA Technical Reports Server (NTRS)

Heimlich, P. F.; Sutton, J. G.; Tepper, E. H.

1972-01-01

Advances in extravehicular life support system technology will directly influence future space mission reliability and maintainability considerations. To identify required new technology areas, an appraisal of advanced portable life support system and subsystem concepts was conducted. Emphasis was placed on thermal control and combined CO2 control/O2 supply subsystems for both primary and emergency systems. A description of study methodology, concept evaluation techniques, specification requirements, and selected subsystems and systems are presented. New technology recommendations encompassing thermal control, CO2 control and O2 supply subsystems are also contained herein.

Advanced computer architecture specification for automated weld systems

NASA Technical Reports Server (NTRS)

Katsinis, Constantine

1994-01-01

This report describes the requirements for an advanced automated weld system and the associated computer architecture, and defines the overall system specification from a broad perspective. According to the requirements of welding procedures as they relate to an integrated multiaxis motion control and sensor architecture, the computer system requirements are developed based on a proven multiple-processor architecture with an expandable, distributed-memory, single global bus architecture, containing individual processors which are assigned to specific tasks that support sensor or control processes. The specified architecture is sufficiently flexible to integrate previously developed equipment, be upgradable and allow on-site modifications.

Protection of Advanced Electrical Power Systems from Atmospheric Electromagnetic Hazards.

DTIC Science & Technology

1981-12-01

WORDS (Continue on reverse aide if neceeary and Identify by block number) Aircraft Induced Voltages Filters Composite Structures Lightning Transients...transients on the electrical systems of aircraft with metal or composite structures. These transients will be higher than the equipment inherent hardness... composite material in skin and structure. In addition, the advanced electrical power systems used in these aircraft will contain solid state components

Advanced Ultrasonic Measurement Methodology for Non-Invasive Interrogation and Identification of Fluids in Sealed Containers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tucker, Brian J.; Diaz, Aaron A.; Eckenrode, Brian A.

2006-03-16

The Hazardous Materials Response Unit (HMRU) and the Counterterrorism and Forensic Science Research Unit (CTFSRU), Laboratory Division, Federal Bureau of Investigation (FBI) have been mandated to develop and establish a wide range of unprecedented capabilities for providing scientific and technical forensic services to investigations involving hazardous chemical, biological, and radiological materials, including extremely dangerous chemical and biological warfare agents. Pacific Northwest National Laboratory (PNNL) has developed a portable, hand-held, hazardous materials acoustic inspection device (HAZAID) that provides noninvasive container interrogation and material identification capabilities using nondestructive ultrasonic velocity and attenuation measurements. Due to the wide variety of fluids as wellmore » as container sizes and materials, the need for high measurement sensitivity and advanced ultrasonic measurement techniques were identified. The HAZAID prototype was developed using a versatile electronics platform, advanced ultrasonic wave propagation methods, and advanced signal processing techniques. This paper primarily focuses on the ultrasonic measurement methods and signal processing techniques incorporated into the HAZAID prototype. High bandwidth ultrasonic transducers combined with the advanced pulse compression technique allowed researchers to 1) impart large amounts of energy, 2) obtain high signal-to-noise ratios, and 3) obtain accurate and consistent time-of-flight (TOF) measurements through a variety of highly attenuative containers and fluid media. Results of this feasibility study demonstrated that the HAZAID experimental measurement technique also provided information regarding container properties, which will be utilized in future container-independent measurements of hidden liquids.« less

NASA Advanced Exploration Systems: Advancements in Life Support Systems

NASA Technical Reports Server (NTRS)

Shull, Sarah A.; Schneider, Walter F.

2016-01-01

The NASA Advanced Exploration Systems (AES) Life Support Systems (LSS) project strives to develop reliable, energy-efficient, and low-mass spacecraft systems to provide environmental control and life support systems (ECLSS) critical to enabling long duration human missions beyond low Earth orbit (LEO). Highly reliable, closed-loop life support systems are among the capabilities required for the longer duration human space exploration missions assessed by NASA’s Habitability Architecture Team.

Advanced Distribution Management Systems | Grid Modernization | NREL

Science.gov Websites

Advanced Distribution Management Systems Advanced Distribution Management Systems Electric utilities are investing in updated grid technologies such as advanced distribution management systems to management testbed for cyber security in power systems. The "advanced" elements of advanced

Passive containment cooling system

DOEpatents

Billig, P.F.; Cooke, F.E.; Fitch, J.R.

1994-01-25

A passive containment cooling system includes a containment vessel surrounding a reactor pressure vessel and defining a drywell therein containing a non-condensable gas. An enclosed wetwell pool is disposed inside the containment vessel, and a gravity driven cooling system (GDCS) pool is disposed above the wetwell pool in the containment vessel and is vented to the drywell. An isolation pool is disposed above the GDCS pool and includes an isolation condenser therein. The condenser has an inlet line disposed in flow communication with the drywell for receiving the non-condensable gas along with any steam released therein following a loss-of-coolant accident (LOCA). The condenser also has an outlet line disposed in flow communication with the drywell for returning to the drywell both liquid condensate produced upon cooling of the steam and the non-condensable gas for reducing pressure within the containment vessel following the LOCA. 1 figure.

Passive containment cooling system

DOEpatents

Billig, Paul F.; Cooke, Franklin E.; Fitch, James R.

1994-01-01

A passive containment cooling system includes a containment vessel surrounding a reactor pressure vessel and defining a drywell therein containing a non-condensable gas. An enclosed wetwell pool is disposed inside the containment vessel, and a gravity driven cooling system (GDCS) pool is disposed above the wetwell pool in the containment vessel and is vented to the drywell. An isolation pool is disposed above the GDCS pool and includes an isolation condenser therein. The condenser has an inlet line disposed in flow communication with the drywell for receiving the non-condensable gas along with any steam released therein following a loss-of-coolant accident (LOCA). The condenser also has an outlet line disposed in flow communication with the drywell for returning to the drywell both liquid condensate produced upon cooling of the steam and the non-condensable gas for reducing pressure within the containment vessel following the LOCA.

Gear systems for advanced turboprops

NASA Technical Reports Server (NTRS)

Wagner, Douglas A.

1987-01-01

A new generation of transport aircraft will be powered by efficient, advanced turboprop propulsion systems. Systems that develop 5,000 to 15,000 horsepower have been studied. Reduction gearing for these advanced propulsion systems is discussed. Allison Gas Turbine Division's experience with the 5,000 horsepower reduction gearing for the T56 engine is reviewed and the impact of that experience on advanced gear systems is considered. The reliability needs for component design and development are also considered. Allison's experience and their research serve as a basis on which to characterize future gear systems that emphasize low cost and high reliability.

Pressure suppression containment system

DOEpatents

Gluntz, Douglas M.; Townsend, Harold E.

1994-03-15

A pressure suppression containment system includes a containment vessel surrounding a reactor pressure vessel and defining a drywell therein containing a non-condensable gas. An enclosed wetwell pool is disposed inside the containment vessel, and a gravity driven cooling system (GDCS) pool is disposed above the wetwell pool in the containment vessel. The wetwell pool includes a plenum for receiving the non-condensable gas carried with steam from the drywell following a loss-of coolant-accident (LOCA). The wetwell plenum is vented to a plenum above the GDCS pool following the LOCA for suppressing pressure rise within the containment vessel. A method of operation includes channeling steam released into the drywell following the LOCA into the wetwell pool for cooling along with the non-condensable gas carried therewith. The GDCS pool is then drained by gravity, and the wetwell plenum is vented into the GDCS plenum for channeling the non-condensable gas thereto.

Pressure suppression containment system

DOEpatents

Gluntz, D.M.; Townsend, H.E.

1994-03-15

A pressure suppression containment system includes a containment vessel surrounding a reactor pressure vessel and defining a drywell therein containing a non-condensable gas. An enclosed wetwell pool is disposed inside the containment vessel, and a gravity driven cooling system (GDCS) pool is disposed above the wetwell pool in the containment vessel. The wetwell pool includes a plenum for receiving the non-condensable gas carried with steam from the drywell following a loss-of-coolant-accident (LOCA). The wetwell plenum is vented to a plenum above the GDCS pool following the LOCA for suppressing pressure rise within the containment vessel. A method of operation includes channeling steam released into the drywell following the LOCA into the wetwell pool for cooling along with the non-condensable gas carried therewith. The GDCS pool is then drained by gravity, and the wetwell plenum is vented into the GDCS plenum for channeling the non-condensable gas thereto. 6 figures.

Research Advances in CKLFSF-like MARVEL Transmembrane Domain Containing Member 3.

PubMed

Hu, Feng-zhan; Sheng, Zheng-zuo; Qin, Cai-peng; Xu, Tao

2016-06-10

CKLF-like MARVEL transmembrane domain containing member/chemokine-like factor super family member (CKLFSF/CMTM) is a novel tumor suppressor gene. CMTM3 is broadly expressed in normal human tissues and evolutionary conserved,especially in testis,spleen,and some cells of peripheral blood mononuclear cells. However,its expression is undetectable or down-regulated in most carcinoma cell lines and tissues. Restoration of CMTM3 may inhibit the proliferation,migration,and invasion of carcinoma cells. Although the exact mechanism of its anti-tumor activity remains unclear,CKLFSF3/CMTM3 is closely connected with immune system and associated with sex during tumorigenesis. The study advances of CKLFSF3/CMTM3 are elaborated in this review as CMTM3 may be a new target in the gene therapies for tumors,especially genitourinary tumors,while further studies on CMTM3 and its anti-tumor mechanisms are warranted.

Advanced collapsible tank for liquid containment

NASA Technical Reports Server (NTRS)

Flanagan, David T.; Hopkins, Robert C.

1993-01-01

Tanks for bulk liquid containment will be required to support advanced planetary exploration programs. Potential applications include storage of potable, process, and waste water, and fuels and process chemicals. The launch mass and volume penalties inherent in rigid tanks suggest that collapsible tanks may be more efficient. Collapsible tanks are made of lightweight flexible material and can be folded compactly for storage and transport. Although collapsible tanks for terrestrial use are widely available, a new design was developed that has significantly less mass and bulk than existing models. Modelled after the shape of a sessible drop, this design features a dual membrane with a nearly uniform stress distribution and a low surface-to-volume ratio. It can be adapted to store a variety of liquids in nearly any environment with constant acceleration field. Three models of 10L, 50L, and 378L capacity have been constructed and tested. The 378L (100 gallon) model weighed less than 10 percent of a commercially available collapsible tank of equivalent capacity, and required less than 20 percent of the storage space when folded for transport.

Containment vessel drain system

DOEpatents

Harris, Scott G.

2018-01-30

A system for draining a containment vessel may include a drain inlet located in a lower portion of the containment vessel. The containment vessel may be at least partially filled with a liquid, and the drain inlet may be located below a surface of the liquid. The system may further comprise an inlet located in an upper portion of the containment vessel. The inlet may be configured to insert pressurized gas into the containment vessel to form a pressurized region above the surface of the liquid, and the pressurized region may operate to apply a surface pressure that forces the liquid into the drain inlet. Additionally, a fluid separation device may be operatively connected to the drain inlet. The fluid separation device may be configured to separate the liquid from the pressurized gas that enters the drain inlet after the surface of the liquid falls below the drain inlet.

Performance of Sequoyah Containment Anchorage System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fanous, F.; Greimann, L.; Wassef, W.

1993-01-01

Deformation of a steel containment anchorage system during a severe accident may result in a leakage path at the containment boundaries. Current design criteria are based on either ductile or brittle failure modes of headed bolts that do not account for factors such as cracking of the containment basemat or deformation of the anchor bolt that may affect the behavior of the containment anchorage system. The purpose of this study was to investigate the performance of a typical ice condenser containment`s anchorage system. This was accomplished by analyzing the Sequoyah Containment Anchorage System. Based on a strength of materials approachmore » and assuming that the anchor bolts are resisting the uplift caused by the internal pressure, one can estimate that the failure of the anchor bolts would occur at a containment pressure of 79 psig. To verify these results and to calibrate the strength of materials equation, the Sequoyah containment anchorage system was analyzed with the ABAQUS program using a three-dimensional, finite-element model. The model included portions of the steel containment building, shield building, anchor bolt assembly, reinforced concrete mat and soil foundation material.« less

Advancements in Root Growth Measurement Technologies and Observation Capabilities for Container-Grown Plants.

PubMed

Judd, Lesley A; Jackson, Brian E; Fonteno, William C

2015-07-03

The study, characterization, observation, and quantification of plant root growth and root systems (Rhizometrics) has been and remains an important area of research in all disciplines of plant science. In the horticultural industry, a large portion of the crops grown annually are grown in pot culture. Root growth is a critical component in overall plant performance during production in containers, and therefore it is important to understand the factors that influence and/or possible enhance it. Quantifying root growth has varied over the last several decades with each method of quantification changing in its reliability of measurement and variation among the results. Methods such as root drawings, pin boards, rhizotrons, and minirhizotrons initiated the aptitude to measure roots with field crops, and have been expanded to container-grown plants. However, many of the published research methods are monotonous and time-consuming. More recently, computer programs have increased in use as technology advances and measuring characteristics of root growth becomes easier. These programs are instrumental in analyzing various root growth characteristics, from root diameter and length of individual roots to branching angle and topological depth of the root architecture. This review delves into the expanding technologies involved with expertly measuring root growth of plants in containers, and the advantages and disadvantages that remain.

Advancements in Root Growth Measurement Technologies and Observation Capabilities for Container-Grown Plants

PubMed Central

Judd, Lesley A.; Jackson, Brian E.; Fonteno, William C.

2015-01-01

The study, characterization, observation, and quantification of plant root growth and root systems (Rhizometrics) has been and remains an important area of research in all disciplines of plant science. In the horticultural industry, a large portion of the crops grown annually are grown in pot culture. Root growth is a critical component in overall plant performance during production in containers, and therefore it is important to understand the factors that influence and/or possible enhance it. Quantifying root growth has varied over the last several decades with each method of quantification changing in its reliability of measurement and variation among the results. Methods such as root drawings, pin boards, rhizotrons, and minirhizotrons initiated the aptitude to measure roots with field crops, and have been expanded to container-grown plants. However, many of the published research methods are monotonous and time-consuming. More recently, computer programs have increased in use as technology advances and measuring characteristics of root growth becomes easier. These programs are instrumental in analyzing various root growth characteristics, from root diameter and length of individual roots to branching angle and topological depth of the root architecture. This review delves into the expanding technologies involved with expertly measuring root growth of plants in containers, and the advantages and disadvantages that remain. PMID:27135334

Recent advances in clay mineral-containing nanocomposite hydrogels.

PubMed

Zhao, Li Zhi; Zhou, Chun Hui; Wang, Jing; Tong, Dong Shen; Yu, Wei Hua; Wang, Hao

2015-12-28

Clay mineral-containing nanocomposite hydrogels have been proven to have exceptional composition, properties, and applications, and consequently have attracted a significant amount of research effort over the past few years. The objective of this paper is to summarize and evaluate scientific advances in clay mineral-containing nanocomposite hydrogels in terms of their specific preparation, formation mechanisms, properties, and applications, and to identify the prevailing challenges and future directions in the field. The state-of-the-art of existing technologies and insights into the exfoliation of layered clay minerals, in particular montmorillonite and LAPONITE®, are discussed first. The formation and structural characteristics of polymer/clay nanocomposite hydrogels made from in situ free radical polymerization, supramolecular assembly, and freezing-thawing cycles are then examined. Studies indicate that additional hydrogen bonding, electrostatic interactions, coordination bonds, hydrophobic interaction, and even covalent bonds could occur between the clay mineral nanoplatelets and polymer chains, thereby leading to the formation of unique three-dimensional networks. Accordingly, the hydrogels exhibit exceptional optical and mechanical properties, swelling-deswelling behavior, and stimuli-responsiveness, reflecting the remarkable effects of clay minerals. With the pivotal roles of clay minerals in clay mineral-containing nanocomposite hydrogels, the nanocomposite hydrogels possess great potential as superabsorbents, drug vehicles, tissue scaffolds, wound dressing, and biosensors. Future studies should lay emphasis on the formation mechanisms with in-depth insights into interfacial interactions, the tactical functionalization of clay minerals and polymers for desired properties, and expanding of their applications.

NASA Advanced Explorations Systems: 2017 Advancements in Life Support Systems

NASA Technical Reports Server (NTRS)

Schneider, Walter F.; Shull, Sarah A.

2017-01-01

The NASA Advanced Exploration Systems (AES) Life Support Systems (LSS) project strives to develop reliable, energy-efficient, and low-mass spacecraft systems to provide environmental control and life support systems (ECLSS) critical to enabling long duration human missions beyond low Earth orbit (LEO). Highly reliable, closed-loop life support systems are among the capabilities required for the longer duration human space exploration missions planned in the mid-2020s and beyond. The LSS Project is focused on four are-as-architecture and systems engineering for life support systems, environmental monitoring, air revitalization, and wastewater processing and water management. Starting with the International Space Station (ISS) LSS systems as a point of departure where applicable, the three-fold mission of the LSS Project is to address discrete LSS technology gaps, to improve the reliability of LSS systems, and to advance LSS systems toward integrated testing aboard the ISS. This paper is a follow on to the AES LSS development status reported in 2016 and provides additional details on the progress made since that paper was published with specific attention to the status of the Aerosol Sampler ISS Flight Experiment, the Spacecraft Atmosphere Monitor (SAM) Flight Experiment, the Brine Processor Assembly (BPA) Flight Experiment, the CO2 removal technology development tasks, and the work investigating the impacts of dormancy on LSS systems.

Underwater Advanced Time-Domain Electromagnetic System

DTIC Science & Technology

2017-03-03

SUPPLEMENTARY NOTES 14. ABSTRACT The overall objective of the project is to design , build and demonstrate an underwater advanced time -domain...Description The overall objective of the project is to design , build and demonstrate an underwater advanced time - domain electromagnetic (TEM) system...Electromagnetic System Design (July, 2015), and in the Underwater Advanced Time -Domain Electromagnetic System Evaluation Plan (October, 2016). A

Advanced information processing system for advanced launch system: Hardware technology survey and projections

NASA Technical Reports Server (NTRS)

Cole, Richard

1991-01-01

The major goals of this effort are as follows: (1) to examine technology insertion options to optimize Advanced Information Processing System (AIPS) performance in the Advanced Launch System (ALS) environment; (2) to examine the AIPS concepts to ensure that valuable new technologies are not excluded from the AIPS/ALS implementations; (3) to examine advanced microprocessors applicable to AIPS/ALS, (4) to examine radiation hardening technologies applicable to AIPS/ALS; (5) to reach conclusions on AIPS hardware building blocks implementation technologies; and (6) reach conclusions on appropriate architectural improvements. The hardware building blocks are the Fault-Tolerant Processor, the Input/Output Sequencers (IOS), and the Intercomputer Interface Sequencers (ICIS).

Self-contained microfluidic systems: a review.

PubMed

Boyd-Moss, Mitchell; Baratchi, Sara; Di Venere, Martina; Khoshmanesh, Khashayar

2016-08-16

Microfluidic systems enable rapid diagnosis, screening and monitoring of diseases and health conditions using small amounts of biological samples and reagents. Despite these remarkable features, conventional microfluidic systems rely on bulky expensive external equipment, which hinders their utility as powerful analysis tools outside of research laboratories. 'Self-contained' microfluidic systems, which contain all necessary components to facilitate a complete assay, have been developed to address this limitation. In this review, we provide an in-depth overview of self-contained microfluidic systems. We categorise these systems based on their operating mechanisms into three major groups: passive, hand-powered and active. Several examples are provided to discuss the structure, capabilities and shortcomings of each group. In particular, we discuss the self-contained microfluidic systems enabled by active mechanisms, due to their unique capability for running multi-step and highly controllable diagnostic assays. Integration of self-contained microfluidic systems with the image acquisition and processing capabilities of smartphones, especially those equipped with accessory optical components, enables highly sensitive and quantitative assays, which are discussed. Finally, the future trends and possible solutions to expand the versatility of self-contained, stand-alone microfluidic platforms are outlined.

Advanced Transport Operating System (ATOPS) control display unit software description

NASA Technical Reports Server (NTRS)

Slominski, Christopher J.; Parks, Mark A.; Debure, Kelly R.; Heaphy, William J.

1992-01-01

The software created for the Control Display Units (CDUs), used for the Advanced Transport Operating Systems (ATOPS) project, on the Transport Systems Research Vehicle (TSRV) is described. Module descriptions are presented in a standardized format which contains module purpose, calling sequence, a detailed description, and global references. The global reference section includes subroutines, functions, and common variables referenced by a particular module. The CDUs, one for the pilot and one for the copilot, are used for flight management purposes. Operations performed with the CDU affects the aircraft's guidance, navigation, and display software.

Earth Observing System (EOS)/Advanced Microwave Sounding Unit-A (AMSU-A): Instrument logic diagrams

NASA Technical Reports Server (NTRS)

1994-01-01

This report contains all of the block diagrams and internal logic diagrams for the Earth Observation System Advanced Microwave Sounding Unit-A (AMSU-A). These diagrams show the signal inputs, outputs, and internal signal flow for the AMSU-A.

Advanced Oxide Material Systems for 1650 C Thermal/Environmental Barrier Coating Applications

NASA Technical Reports Server (NTRS)

Zhu, Dong-Ming; Fox, Dennis S.; Bansal, Narottam P.; Miller, Robert A.

2004-01-01

Advanced thermal and environmental barrier coatings (TEBCs) are being developed for low-emission SiC/SiC ceramic matrix composite (CMC) combustor and vane applications to extend the CMC liner and vane temperature capability to 1650 C (3000 F) in oxidizing and water-vapor-containing combustion environments. The advanced 1650 C TEBC system is required to have a better high-temperature stability, lower thermal conductivity, and more resistance to sintering and thermal stress than current coating systems under engine high-heat-flux and severe thermal cycling conditions. In this report, the thermal conductivity and water vapor stability of selected candidate hafnia-, pyrochlore- and magnetoplumbite-based TEBC materials are evaluated. The effects of dopants on the materials properties are also discussed. The test results have been used to downselect the TEBC materials and help demonstrate the feasibility of advanced 1650 C coatings with long-term thermal cycling durability.

Advanced Technology Lifecycle Analysis System (ATLAS) Technology Tool Box (TTB)

NASA Technical Reports Server (NTRS)

Doyle, Monica; ONeil, Daniel A.; Christensen, Carissa B.

2005-01-01

The Advanced Technology Lifecycle Analysis System (ATLAS) is a decision support tool designed to aid program managers and strategic planners in determining how to invest technology research and development dollars. It is an Excel-based modeling package that allows a user to build complex space architectures and evaluate the impact of various technology choices. ATLAS contains system models, cost and operations models, a campaign timeline and a centralized technology database. Technology data for all system models is drawn from a common database, the ATLAS Technology Tool Box (TTB). The TTB provides a comprehensive, architecture-independent technology database that is keyed to current and future timeframes.

Advanced optical manufacturing digital integrated system

NASA Astrophysics Data System (ADS)

Tao, Yizheng; Li, Xinglan; Li, Wei; Tang, Dingyong

2012-10-01

It is necessarily to adapt development of advanced optical manufacturing technology with modern science technology development. To solved these problems which low of ration, ratio of finished product, repetition, consistent in big size and high precision in advanced optical component manufacturing. Applied business driven and method of Rational Unified Process, this paper has researched advanced optical manufacturing process flow, requirement of Advanced Optical Manufacturing integrated System, and put forward architecture and key technology of it. Designed Optical component core and Manufacturing process driven of Advanced Optical Manufacturing Digital Integrated System. the result displayed effective well, realized dynamic planning Manufacturing process, information integration improved ratio of production manufactory.

Passive containment cooling system

DOEpatents

Conway, Lawrence E.; Stewart, William A.

1991-01-01

A containment cooling system utilizes a naturally induced air flow and a gravity flow of water over the containment shell which encloses a reactor core to cool reactor core decay heat in two stages. When core decay heat is greatest, the water and air flow combine to provide adequate evaporative cooling as heat from within the containment is transferred to the water flowing over the same. The water is heated by heat transfer and then evaporated and removed by the air flow. After an initial period of about three to four days when core decay heat is greatest, air flow alone is sufficient to cool the containment.

Advanced Oxide Material Systems For 1650 C Thermal/Environmental Barrier Coating Applications

NASA Technical Reports Server (NTRS)

Zhu, Dongming; Fox, Dennis S.; Bansal, Narottam P.; Miller, Robert A.

2004-01-01

Advanced thermal/environmental barrier coatings (T/EBCs) are being developed for low emission SiC/SiC ceramic matrix composite (CMC) combustor and vane applications to extend the CMC liner and vane temperature capability to 1650 C (3000 F) in oxidizing and water-vapor containing combustion environments. The 1650 C T/EBC system is required to have better thermal stability, lower thermal conductivity, and improved sintering and thermal stress resistance than current coating systems. In this paper, the thermal conductivity, water vapor stability and cyclic durability of selected candidate zirconia-/hafnia-, pyrochlore- and magnetoplumbite-based T/EBC materials are evaluated. The test results have been used to downselect the T/EBC coating materials, and help demonstrate advanced 1650OC coatings feasibility with long-term cyclic durability.

Does human cognition allow Human Factors (HF) certification of advanced aircrew systems?

NASA Technical Reports Server (NTRS)

Macleod, Iain S.; Taylor, Robert M.

1994-01-01

This paper has examined the requirements of HF specification and certification within advanced or complex aircrew systems. It suggests reasons for current inadequacies in the use of HF in the design process, giving some examples in support, and suggesting an avenue towards the improvement of the HF certification process. The importance of human cognition to the operation and performance of advanced aircrew systems has been stressed. Many of the shortfalls of advanced aircrew systems must be attributed to over automated designs that show little consideration on either the mental limits or the cognitive capabilities of the human system component. Traditional approaches to system design and HF certification are set within an over physicalistic foundation. Also, traditionally it was assumed that physicalistic system functions could be attributed to either the human or the machine on a one to one basis. Moreover, any problems associated with the parallel needs, or promoting human understanding alongside system operation and direction, were generally equated in reality by the natural flexibility and adaptability of human skills. The consideration of the human component of a complex system is seen as being primarily based on manifestations of human behavior to the almost total exclusion of any appreciation of unobservable human mental and cognitive processes. The argument of this paper is that the considered functionality of any complex human-machine system must contain functions that are purely human and purely cognitive. Human-machine system reliability ultimately depends on human reliability and dependability and, therefore, on the form and frequency of cognitive processes that have to be conducted to support system performance. The greater the demand placed by an advanced aircraft system on the human component's basic knowledge processes or cognition, rather than on skill, the more insiduous the effects the human may have on that system. This paper discusses one

The Advanced Technology Operations System: ATOS

NASA Technical Reports Server (NTRS)

Kaufeler, J.-F.; Laue, H. A.; Poulter, K.; Smith, H.

1993-01-01

Mission control systems supporting new space missions face ever-increasing requirements in terms of functionality, performance, reliability and efficiency. Modern data processing technology is providing the means to meet these requirements in new systems under development. During the past few years the European Space Operations Centre (ESOC) of the European Space Agency (ESA) has carried out a number of projects to demonstrate the feasibility of using advanced software technology, in particular, knowledge based systems, to support mission operations. A number of advances must be achieved before these techniques can be moved towards operational use in future missions, namely, integration of the applications into a single system framework and generalization of the applications so that they are mission independent. In order to achieve this goal, ESA initiated the Advanced Technology Operations System (ATOS) program, which will develop the infrastructure to support advanced software technology in mission operations, and provide applications modules to initially support: Mission Preparation, Mission Planning, Computer Assisted Operations, and Advanced Training. The first phase of the ATOS program is tasked with the goal of designing and prototyping the necessary system infrastructure to support the rest of the program. The major components of the ATOS architecture is presented. This architecture relies on the concept of a Mission Information Base (MIB) as the repository for all information and knowledge which will be used by the advanced application modules in future mission control systems. The MIB is being designed to exploit the latest in database and knowledge representation technology in an open and distributed system. In conclusion the technological and implementation challenges expected to be encountered, as well as the future plans and time scale of the project, are presented.

2006 Marine Corps Systems Command Advanced Planning Briefing to Industry

DTIC Science & Technology

2006-04-14

Virginia Beach 34 5 m ile s 34 5 m ile s 2 00 m ile s Philadelphia 9 Video of AAV and EFV 10 Success Story – Amphibious Assault Vehicle Turret...Director Information Systems & InfrastructureProduct Group 10 Overview, Ms. Elizabeth Sedlacek Product Group Director Advanced Planning Briefing to...managers. The slick sheets will contain the names and phone numbers of everyone in the product groups. Corporate – Ms. Gloria Pryor & Ms. Tammy York PG 10

Assurance Technology Challenges of Advanced Space Systems

NASA Technical Reports Server (NTRS)

Chern, E. James

2004-01-01

The initiative to explore space and extend a human presence across our solar system to revisit the moon and Mars post enormous technological challenges to the nation's space agency and aerospace industry. Key areas of technology development needs to enable the endeavor include advanced materials, structures and mechanisms; micro/nano sensors and detectors; power generation, storage and management; advanced thermal and cryogenic control; guidance, navigation and control; command and data handling; advanced propulsion; advanced communication; on-board processing; advanced information technology systems; modular and reconfigurable systems; precision formation flying; solar sails; distributed observing systems; space robotics; and etc. Quality assurance concerns such as functional performance, structural integrity, radiation tolerance, health monitoring, diagnosis, maintenance, calibration, and initialization can affect the performance of systems and subsystems. It is thus imperative to employ innovative nondestructive evaluation methodologies to ensure quality and integrity of advanced space systems. Advancements in integrated multi-functional sensor systems, autonomous inspection approaches, distributed embedded sensors, roaming inspectors, and shape adaptive sensors are sought. Concepts in computational models for signal processing and data interpretation to establish quantitative characterization and event determination are also of interest. Prospective evaluation technologies include ultrasonics, laser ultrasonics, optics and fiber optics, shearography, video optics and metrology, thermography, electromagnetics, acoustic emission, x-ray, data management, biomimetics, and nano-scale sensing approaches for structural health monitoring.

High-temperature thermal storage systems for advanced solar receivers materials selections

NASA Astrophysics Data System (ADS)

Wilson, D. F.; Devan, J. H.; Howell, M.

1990-09-01

Advanced space power systems that use solar energy and Brayton or Stirling heat engines require thermal energy storage (TES) systems to operate continuously through periods of shade. The receiver storage units, key elements in both Brayton and Stirling systems, are designed to use the latent heat of fusion of phase-change materials (PCMs). The power systems under current consideration for near-future National Aeronautics and Space Administration space missions require working fluid temperatures in the 1100 to 1400 K range. The PCMs under current investigation that gave liquid temperatures within this range are the fluoride family of salts. However, these salts have low thermal conductivity, which causes large temperature gradients in the storage systems. Improvements can be obtained, however, with the use of thermal conductivity enhancements or metallic PCMs. In fact, if suitable containment materials can be found, the use of metallic PCMs would virtually eliminate the orbit associated temperature variations in TES systems. The high thermal conductivity and generally low volume change on melting of germanium and alloys based on silicon make them attractive for storage of thermal energy in space power systems. An approach to solving the containment problem, involving both chemical and physical compatibility, preparation of NiSi/NiSi2, and initial results for containment of germanium and NiSi/NiSi2, are presented.

High-temperature thermal storage systems for advanced solar receivers materials selections

NASA Technical Reports Server (NTRS)

Wilson, D. F.; Devan, J. H.; Howell, M.

1990-01-01

Advanced space power systems that use solar energy and Brayton or Stirling heat engines require thermal energy storage (TES) systems to operate continuously through periods of shade. The receiver storage units, key elements in both Brayton and Stirling systems, are designed to use the latent heat of fusion of phase-change materials (PCMs). The power systems under current consideration for near-future National Aeronautics and Space Administration space missions require working fluid temperatures in the 1100 to 1400 K range. The PCMs under current investigation that gave liquid temperatures within this range are the fluoride family of salts. However, these salts have low thermal conductivity, which causes large temperature gradients in the storage systems. Improvements can be obtained, however, with the use of thermal conductivity enhancements or metallic PCMs. In fact, if suitable containment materials can be found, the use of metallic PCMs would virtually eliminate the orbit associated temperature variations in TES systems. The high thermal conductivity and generally low volume change on melting of germanium and alloys based on silicon make them attractive for storage of thermal energy in space power systems. An approach to solving the containment problem, involving both chemical and physical compatibility, preparation of NiSi/NiSi2, and initial results for containment of germanium and NiSi/NiSi2, are presented.

75 FR 44015 - Certain Semiconductor Products Made by Advanced Lithography Techniques and Products Containing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-27

... INTERNATIONAL TRADE COMMISSION [Inv. No. 337-TA-729] Certain Semiconductor Products Made by... the sale within the United States after importation of certain semiconductor products made by advanced lithography techniques and products containing same by reason of infringement of certain claims of U.S. Patent...

Data management system advanced development

NASA Technical Reports Server (NTRS)

Douglas, Katherine; Humphries, Terry

1990-01-01

The Data Management System (DMS) Advanced Development task provides for the development of concepts, new tools, DMS services, and for the testing of the Space Station DMS hardware and software. It also provides for the development of techniques capable of determining the effects of system changes/enhancements, additions of new technology, and/or hardware and software growth on system performance. This paper will address the built-in characteristics which will support network monitoring requirements in the design of the evolving DMS network implementation, functional and performance requirements for a real-time, multiprogramming, multiprocessor operating system, and the possible use of advanced development techniques such as expert systems and artificial intelligence tools in the DMS design.

Advanced Solar Power Systems

NASA Technical Reports Server (NTRS)

Atkinson, J. H.; Hobgood, J. M.

1984-01-01

The Advanced Solar Power System (ASPS) concentrator uses a technically sophisticated design and extensive tooling to produce very efficient (80 to 90%) and versatile energy supply equipment which is inexpensive to manufacture and requires little maintenance. The advanced optical design has two 10th order, generalized aspheric surfaces in a Cassegrainian configuration which gives outstanding performance and is relatively insensitive to temperature changes and wind loading. Manufacturing tolerances also have been achieved. The key to the ASPS is the direct absorption of concentrated sunlight in the working fluid by radiative transfers in a black body cavity. The basic ASPS design concepts, efficiency, optical system, and tracking and focusing controls are described.

40 CFR 265.223 - Containment system.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Containment system. 265.223 Section 265.223 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED... FACILITIES Surface Impoundments § 265.223 Containment system. All earthen dikes must have a protective cover...

40 CFR 265.223 - Containment system.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Containment system. 265.223 Section 265.223 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED... FACILITIES Surface Impoundments § 265.223 Containment system. All earthen dikes must have a protective cover...

Advances in hypersonic vehicle synthesis with application to studies of advanced thermal protection system

NASA Technical Reports Server (NTRS)

Ardema, Mark D.

1995-01-01

This report summarizes the work entitled 'Advances in Hypersonic Vehicle Synthesis with Application to Studies of Advanced Thermal Protection Systems.' The effort was in two areas: (1) development of advanced methods of trajectory and propulsion system optimization; and (2) development of advanced methods of structural weight estimation. The majority of the effort was spent in the trajectory area.

Advanced information processing system

NASA Technical Reports Server (NTRS)

Lala, J. H.

1984-01-01

Design and performance details of the advanced information processing system (AIPS) for fault and damage tolerant data processing on aircraft and spacecraft are presented. AIPS comprises several computers distributed throughout the vehicle and linked by a damage tolerant data bus. Most I/O functions are available to all the computers, which run in a TDMA mode. Each computer performs separate specific tasks in normal operation and assumes other tasks in degraded modes. Redundant software assures that all fault monitoring, logging and reporting are automated, together with control functions. Redundant duplex links and damage-spread limitation provide the fault tolerance. Details of an advanced design of a laboratory-scale proof-of-concept system are described, including functional operations.

Advanced Telemetry System Development.

DTIC Science & Technology

Progress in advanced telemetry system development is described. Discussions are included of studies leading to the specification for design...characteristics of adaptive and analytical telemetry systems in which the information efficiently utilizes the data channel capacity. Also discussed are...Progress indicates that further sophistication of existing designs in telemetry will be less advantageous than the development of new systems of

Advanced Vehicle system concepts. [nonpetroleum passenger transportation

NASA Technical Reports Server (NTRS)

Hardy, K. S.; Langendoen, J. M.

1983-01-01

Various nonpetroleum vehicle system concepts for passenger vehicles in the 1990's are being considered as part of the Advanced Vehicle (AV) Assessment at the Jet Propulsion Laboratory. The vehicle system and subsystem performance requirements, the projected characteristics of mature subsystem candidates, and promising systems are presented. The system candidates include electric and hybrid vehicles powered by electricity with or without a nonpetroleum power source. The subsystem candidates include batteries (aqueous-mobile, flow, high-temperature, and metal-air), fuel cells (phosphoric acid, advanced acids, and solid polymer electrolyte), nonpetroleum heat engines, advanced dc and ac propulsion components, power-peaking devices, and transmissions.

Demonstration Advanced Avionics System (DAAS), Phase 1

NASA Technical Reports Server (NTRS)

Bailey, A. J.; Bailey, D. G.; Gaabo, R. J.; Lahn, T. G.; Larson, J. C.; Peterson, E. M.; Schuck, J. W.; Rodgers, D. L.; Wroblewski, K. A.

1981-01-01

Demonstration advanced anionics system (DAAS) function description, hardware description, operational evaluation, and failure mode and effects analysis (FMEA) are provided. Projected advanced avionics system (PAAS) description, reliability analysis, cost analysis, maintainability analysis, and modularity analysis are discussed.

Underwater Advanced Time-Domain Electromagnetic System

DTIC Science & Technology

2017-03-01

distribution statement initially submitted with AD1042986, entitled Underwater Advanced Time Domain Electromagnetic System (MR-201313), has been appealed...Advanced Time -Domain Electromagnetic System ESTCP Project MR-201313 MARCH 2017 Mr. Steve Saville CH2M Distribution Statement D: Distribution...is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and

Noise impact of advanced high lift systems

NASA Technical Reports Server (NTRS)

Elmer, Kevin R.; Joshi, Mahendra C.

1995-01-01

The impact of advanced high lift systems on aircraft size, performance, direct operating cost and noise were evaluated for short-to-medium and medium-to-long range aircraft with high bypass ratio and very high bypass ratio engines. The benefit of advanced high lift systems in reducing noise was found to be less than 1 effective-perceived-noise decibel level (EPNdB) when the aircraft were sized to minimize takeoff gross weight. These aircraft did, however, have smaller wings and lower engine thrusts for the same mission than aircraft with conventional high lift systems. When the advanced high lift system was implemented without reducing wing size and simultaneously using lower flap angles that provide higher L/D at approach a cumulative noise reduction of as much as 4 EPNdB was obtained. Comparison of aircraft configurations that have similar approach speeds showed cumulative noise reduction of 2.6 EPNdB that is purely the result of incorporating advanced high lift system in the aircraft design.

Review of advanced driver assistance systems (ADAS)

NASA Astrophysics Data System (ADS)

Ziebinski, Adam; Cupek, Rafal; Grzechca, Damian; Chruszczyk, Lukas

2017-11-01

New cars can be equipped with many advanced safety solutions. Airbags, seatbelts and all of the essential passive safety parts are standard equipment. Now cars are often equipped with new advanced active safety systems that can prevent accidents. The functions of the Advanced Driver Assistance Systems are still growing. A review of the most popular available technologies used in ADAS and descriptions of their application areas are discussed in this paper.

Advanced imaging system

NASA Technical Reports Server (NTRS)

1992-01-01

This document describes the Advanced Imaging System CCD based camera. The AIS1 camera system was developed at Photometric Ltd. in Tucson, Arizona as part of a Phase 2 SBIR contract No. NAS5-30171 from the NASA/Goddard Space Flight Center in Greenbelt, Maryland. The camera project was undertaken as a part of the Space Telescope Imaging Spectrograph (STIS) project. This document is intended to serve as a complete manual for the use and maintenance of the camera system. All the different parts of the camera hardware and software are discussed and complete schematics and source code listings are provided.

Design options for advanced manned launch systems

NASA Astrophysics Data System (ADS)

Freeman, Delma C.; Talay, Theodore A.; Stanley, Douglas O.; Lepsch, Roger A.; Wilhite, Alan W.

1995-03-01

Various concepts for advanced manned launch systems are examined for delivery missions to space station and polar orbit. Included are single-and two-stage winged systems with rocket and/or air-breathing propulsion systems. For near-term technologies, two-stage reusable rocket systems are favored over single-stage rocket or two-stage air-breathing/rocket systems. Advanced technologies enable viable single-stage-to-orbit (SSTO) concepts. Although two-stage rocket systems continue to be lighter in dry weight than SSTO vehicles, advantages in simpler operations may make SSTO vehicles more cost-effective over the life cycle. Generally, rocket systems maintain a dry-weight advantage over air-breathing systems at the advanced technology levels, but to a lesser degree than when near-term technologies are used. More detailed understanding of vehicle systems and associated ground and flight operations requirements and procedures is essential in determining quantitative discrimination between these latter concepts.

Advanced public transportation systems benefits

DOT National Transportation Integrated Search

1996-03-01

Benefits and cost savings for various Advanced Public Transportation Systems are outlined here. Operational efficiencies are given for Transit Management Systems in different locales, as well as compliant resolution and safety. Electronic Fare Paymen...

Driving Change in Community Colleges. Volume 1: Building Systems for Advancement to Self-Sufficiency; Volume 2: An Analysis of Change in Two Community Colleges.

ERIC Educational Resources Information Center

Liebowitz, Marty; Haynes, Leslie; Milley, Jane

This report contains two volumes: "Building Systems for Advancement to Self-Sufficiency," and "An Analysis of Change in Two Community Colleges." Volume 1 addresses the following topics: (1) the need and opportunity for change; (2) from promising practices toward systems for advancement; (3) institutional change strategies; (4) levers for…

Engine health monitoring: An advanced system

NASA Technical Reports Server (NTRS)

Dyson, R. J. E.

1981-01-01

The advanced propulsion monitoring system is described. The system was developed in order to fulfill a growing need for effective engine health monitoring. This need is generated by military requirements for increased performance and efficiency in more complex propulsion systems, while maintaining or improving the cost to operate. This program represents a vital technological step in the advancement of the state of the art for monitoring systems in terms of reliability, flexibility, accuracy, and provision of user oriented results. It draws heavily on the technology and control theory developed for modern, complex, electronically controlled engines and utilizes engine information which is a by-product of such a system.

Water Containment Systems for Testing High-Speed Flywheels

NASA Technical Reports Server (NTRS)

Trase, Larry; Thompson, Dennis

2006-01-01

Water-filled containers are used as building blocks in a new generation of containment systems for testing high-speed flywheels. Such containment systems are needed to ensure safety by trapping high-speed debris in the event of centrifugal breakup or bearing failure. Traditional containment systems for testing flywheels consist mainly of thick steel rings. The effectiveness of this approach to shielding against high-speed debris was demonstrated in a series of tests.

Overview of Advanced Turbine Systems Program

NASA Astrophysics Data System (ADS)

Webb, H. A.; Bajura, R. A.

The US Department of Energy initiated a program to develop advanced gas turbine systems to serve both central power and industrial power generation markets. The Advanced Turbine Systems (ATS) Program will lead to commercial offerings by the private sector by 2002. ATS will be developed to fire natural gas but will be adaptable to coal and biomass firing. The systems will be: highly efficient (15 percent improvement over today's best systems); environmentally superior (10 percent reduction in nitrogen oxides over today's best systems); and cost competitive (10 percent reduction in cost of electricity). The ATS Program has five elements. Innovative cycle development will lead to the demonstration of systems with advanced gas turbine cycles using current gas turbine technology. High temperature development will lead to the increased firing temperatures needed to achieve ATS Program efficiency goals. Ceramic component development/demonstration will expand the current DOE/CE program to demonstrate industrial-scale turbines with ceramic components. Technology base will support the overall program by conducting research and development (R&D) on generic technology issues. Coal application studies will adapt technology developed in the ATS program to coal-fired systems being developed in other DOE programs.

Containment system for supercritical water oxidation reactor

DOEpatents

Chastagner, Philippe

1994-01-01

A system for containment of a supercritical water oxidation reactor in the event of a rupture of the reactor. The system includes a containment for housing the reaction vessel and a communicating chamber for holding a volume of coolant, such as water. The coolant is recirculated and sprayed to entrain and cool any reactants that might have escaped from the reaction vessel. Baffles at the entrance to the chamber prevent the sprayed coolant from contacting the reaction vessel. An impact-absorbing layer is positioned between the vessel and the containment to at least partially absorb momentum of any fragments propelled by the rupturing vessel. Remote, quick-disconnecting fittings exterior to the containment, in cooperation with shut-off valves, enable the vessel to be isolated and the system safely taken off-line. Normally-closed orifices throughout the containment and chamber enable decontamination of interior surfaces when necessary.

Containment system for supercritical water oxidation reactor

DOEpatents

Chastagner, P.

1994-07-05

A system is described for containment of a supercritical water oxidation reactor in the event of a rupture of the reactor. The system includes a containment for housing the reaction vessel and a communicating chamber for holding a volume of coolant, such as water. The coolant is recirculated and sprayed to entrain and cool any reactants that might have escaped from the reaction vessel. Baffles at the entrance to the chamber prevent the sprayed coolant from contacting the reaction vessel. An impact-absorbing layer is positioned between the vessel and the containment to at least partially absorb momentum of any fragments propelled by the rupturing vessel. Remote, quick-disconnecting fittings exterior to the containment, in cooperation with shut-off valves, enable the vessel to be isolated and the system safely taken off-line. Normally-closed orifices throughout the containment and chamber enable decontamination of interior surfaces when necessary. 2 figures.

Advance prototype silver ion water bactericide system

NASA Technical Reports Server (NTRS)

Jasionowski, W. J.; Allen, E. T.

1974-01-01

An advance prototype unit was designed and fabricated to treat anticipated fuel cell water. The unit is a single canister that contains a membrane-type prefilter and a silver bromide contacting bed. A seven day baseline simulated mission test was performed; the performance was satisfactory and the effluent water was within all specifications for potability. After random vibrations another seven day simulated mission test was performed, and results indicate that simulated launch vibrations have no effects on the design and performance of the advanced prototype. Bench tests and accelerated breadboard tests were conducted to define the characteristics of an upgraded model of the advance prototype unit which would have 30 days of operating capability. A preliminary design of a silver ion generator for the shuttle orbiter was also prepared.

EVALUATION OF CONTAINMENT SYSTEMS USING HYDRAULIC HEAD DATA

EPA Science Inventory

Subsurface vertical barriers have been used as components of containment systems to prevent or reduce the impact of containment sources on ground-water resources. Many containment systems also include a low permeability cover to prevent the infiltration-/recharge of precipitatio...

System for inspection of stacked cargo containers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Derenzo, Stephen

The present invention relates to a system for inspection of stacked cargo containers. One embodiment of the invention generally comprises a plurality of stacked cargo containers arranged in rows or tiers, each container having a top, a bottom a first side, a second side, a front end, and a back end; a plurality of spacers arranged in rows or tiers; one or more mobile inspection devices for inspecting the cargo containers, wherein the one or more inspection devices are removeably disposed within the spacers, the inspection means configured to move through the spacers to detect radiation within the containers. Themore » invented system can also be configured to inspect the cargo containers for a variety of other potentially hazardous materials including but not limited to explosive and chemical threats.« less

Advanced uncertainty modelling for container port risk analysis.

PubMed

Alyami, Hani; Yang, Zaili; Riahi, Ramin; Bonsall, Stephen; Wang, Jin

2016-08-13

Globalization has led to a rapid increase of container movements in seaports. Risks in seaports need to be appropriately addressed to ensure economic wealth, operational efficiency, and personnel safety. As a result, the safety performance of a Container Terminal Operational System (CTOS) plays a growing role in improving the efficiency of international trade. This paper proposes a novel method to facilitate the application of Failure Mode and Effects Analysis (FMEA) in assessing the safety performance of CTOS. The new approach is developed through incorporating a Fuzzy Rule-Based Bayesian Network (FRBN) with Evidential Reasoning (ER) in a complementary manner. The former provides a realistic and flexible method to describe input failure information for risk estimates of individual hazardous events (HEs) at the bottom level of a risk analysis hierarchy. The latter is used to aggregate HEs safety estimates collectively, allowing dynamic risk-based decision support in CTOS from a systematic perspective. The novel feature of the proposed method, compared to those in traditional port risk analysis lies in a dynamic model capable of dealing with continually changing operational conditions in ports. More importantly, a new sensitivity analysis method is developed and carried out to rank the HEs by taking into account their specific risk estimations (locally) and their Risk Influence (RI) to a port's safety system (globally). Due to its generality, the new approach can be tailored for a wide range of applications in different safety and reliability engineering and management systems, particularly when real time risk ranking is required to measure, predict, and improve the associated system safety performance. Copyright © 2016 Elsevier Ltd. All rights reserved.

Advanced Algal Systems Fact Sheet

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2016-06-01

Research and development (R&D) on advanced algal biofuels and bioproducts presents an opportunity to sustainably expand biomass resource potential in the United States. The Bioenergy Technologies Office’s (BETO’s) Advanced Algal Systems Program is carrying out a long-term, applied R&D strategy to lower the costs of algal biofuel production by working with partners to develop revolutionary technologies and conduct crosscutting analyses to better understand the potential

Advanced CO2 Removal and Reduction System

NASA Technical Reports Server (NTRS)

Alptekin, Gokhan; Dubovik, Margarita; Copeland, Robert J.

2011-01-01

An advanced system for removing CO2 and H2O from cabin air, reducing the CO2, and returning the resulting O2 to the air is less massive than is a prior system that includes two assemblies . one for removal and one for reduction. Also, in this system, unlike in the prior system, there is no need to compress and temporarily store CO2. In this present system, removal and reduction take place within a single assembly, wherein removal is effected by use of an alkali sorbent and reduction is effected using a supply of H2 and Ru catalyst, by means of the Sabatier reaction, which is CO2 + 4H2 CH4 + O2. The assembly contains two fixed-bed reactors operating in alternation: At first, air is blown through the first bed, which absorbs CO2 and H2O. Once the first bed is saturated with CO2 and H2O, the flow of air is diverted through the second bed and the first bed is regenerated by supplying it with H2 for the Sabatier reaction. Initially, the H2 is heated to provide heat for the regeneration reaction, which is endothermic. In the later stages of regeneration, the Sabatier reaction, which is exothermic, supplies the heat for regeneration.

Advanced Grid Control Technologies Workshop Series | Energy Systems

Science.gov Websites

on advanced distribution management systems (ADMS) and microgrid controls. The workshops were held at . July 7, 2015: Advanced Distribution Management Systems (ADMS) Welcome and NREL Overview Dr. Murali Keynote: Next-Generation Distribution Management Systems and Distributed Resource Energy Management

Learning to Control Advanced Life Support Systems

NASA Technical Reports Server (NTRS)

Subramanian, Devika

2004-01-01

Advanced life support systems have many interacting processes and limited resources. Controlling and optimizing advanced life support systems presents unique challenges. In particular, advanced life support systems are nonlinear coupled dynamical systems and it is difficult for humans to take all interactions into account to design an effective control strategy. In this project. we developed several reinforcement learning controllers that actively explore the space of possible control strategies, guided by rewards from a user specified long term objective function. We evaluated these controllers using a discrete event simulation of an advanced life support system. This simulation, called BioSim, designed by Nasa scientists David Kortenkamp and Scott Bell has multiple, interacting life support modules including crew, food production, air revitalization, water recovery, solid waste incineration and power. They are implemented in a consumer/producer relationship in which certain modules produce resources that are consumed by other modules. Stores hold resources between modules. Control of this simulation is via adjusting flows of resources between modules and into/out of stores. We developed adaptive algorithms that control the flow of resources in BioSim. Our learning algorithms discovered several ingenious strategies for maximizing mission length by controlling the air and water recycling systems as well as crop planting schedules. By exploiting non-linearities in the overall system dynamics, the learned controllers easily out- performed controllers written by human experts. In sum, we accomplished three goals. We (1) developed foundations for learning models of coupled dynamical systems by active exploration of the state space, (2) developed and tested algorithms that learn to efficiently control air and water recycling processes as well as crop scheduling in Biosim, and (3) developed an understanding of the role machine learning in designing control systems for

Rotorcraft digital advanced avionics system (RODAAS) functional description

NASA Technical Reports Server (NTRS)

Peterson, E. M.; Bailey, J.; Mcmanus, T. J.

1985-01-01

A functional design of a rotorcraft digital advanced avionics system (RODAAS) to transfer the technology developed for general aviation in the Demonstration Advanced Avionics System (DAAS) program to rotorcraft operation was undertaken. The objective was to develop an integrated avionics system design that enhances rotorcraft single pilot IFR operations without increasing the required pilot training/experience by exploiting advanced technology in computers, busing, displays and integrated systems design. A key element of the avionics system is the functionally distributed architecture that has the potential for high reliability with low weight, power and cost. A functional description of the RODAAS hardware and software functions is presented.

Advanced vehicle systems assessment. Volume 3: Systems assessment

NASA Technical Reports Server (NTRS)

Hardy, K.

1985-01-01

The systems analyses integrate the advanced component and vehicle characteristics into conceptual vehicles with identical performance (for a given application) and evaluates the vehicles in typical use patterns. Initial and life-cycle costs are estimated and compared to conventional reference vehicles with comparable technological advances, assuming the vehicles will be in competition in the early 1990s. Electric vans, commuter vehicles, and full-size vehicles, in addition to electric/heat-engine hybrid and fuel-cell powered vehicles, are addressed in terms of performance and economics. System and subsystem recommendations for vans and two-passenger commuter vehicles are based on the economic analyses in this volume.

Advanced Distribution Management System

NASA Astrophysics Data System (ADS)

Avazov, Artur R.; Sobinova, Liubov A.

2016-02-01

This article describes the advisability of using advanced distribution management systems in the electricity distribution networks area and considers premises of implementing ADMS within the Smart Grid era. Also, it gives the big picture of ADMS and discusses the ADMS advantages and functionalities.

Advanced Life Support Systems

NASA Technical Reports Server (NTRS)

Barta, Daniel J.

2004-01-01

This presentation is planned to be a 10-15 minute "catalytic" focused presentation to be scheduled during one of the working sessions at the TIM. This presentation will focus on Advanced Life Support technologies key to future human Space Exploration as outlined in the Vision, and will include basic requirements, assessment of the state-of-the-art and gaps, and include specific technology metrics. The presentation will be technical in character, lean heavily on data in published ALS documents (such as the Baseline Values and Assumptions Document) but not provide specific technical details or build to information on any technology mentioned (thus the presentation will be benign from an export control and a new technology perspective). The topics presented will be focused on the following elements of Advanced Life Support: air revitalization, water recovery, waste management, thermal control, habitation systems, food systems and bioregenerative life support.

US Advanced Freight and Passenger MAGLEV System

NASA Technical Reports Server (NTRS)

Morena, John J.; Danby, Gordon; Powell, James

1996-01-01

Japan and Germany will operate first generation Maglev passenger systems commercially shortly after 2000 A.D. The United States Maglev systems will require sophisticated freight and passenger carrying capability. The U.S. freight market is larger than passenger transport. A proposed advanced freight and passenger Maglev Project in Brevard County Florida is described. Present Maglev systems cost 30 million dollars or more per mile. Described is an advanced third generation Maglev system with technology improvements that will result in a cost of 10 million dollars per mile.

Advanced gas turbine systems program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zeh, C.M.

1995-06-01

The U.S. Department of Energy (DOE) is sponsoring a program to develop fuel-efficient gas turbine-based power systems with low emissions. DOE`s Office of Fossil Energy (DOE/FE) and Office of Energy Efficiency and Renewable Energy (DOE/EE) have initiated an 8-year program to develop high-efficiency, natural gas-fired advanced gas turbine power systems. The Advanced Turbine Systems (ATS) Program will support full-scale prototype demonstration of both industrial- and utility-scale systems that will provide commercial marketplace entries by the year 2000. When the program targets are met, power system emissions will be lower than from the best technology in use today. Efficiency of themore » utility-scale units will be greater than 60 percent on a lower heating value basis, and emissions of carbon dioxide will be reduced inversely with this increase. Industrial systems will also see an improvement of at least 15 percent in efficiency. Nitrogen oxides will be reduced by at least 10 percent, and carbon monoxide and hydrocarbon emissions will each be kept below 20 parts per million, for both utility and industrial systems.« less

48 CFR 728.105-1 - Advance payment bonds.

Code of Federal Regulations, 2011 CFR

2011-10-01

....105-1 Section 728.105-1 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 728.105-1 Advance payment bonds. (a) Generally, advance payment bonds will not be required in connection with USAID contracts containing an advance...

48 CFR 728.105-1 - Advance payment bonds.

Code of Federal Regulations, 2010 CFR

2010-10-01

....105-1 Section 728.105-1 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 728.105-1 Advance payment bonds. (a) Generally, advance payment bonds will not be required in connection with USAID contracts containing an advance...

Advanced Clothing System

NASA Technical Reports Server (NTRS)

Broyan, James; Orndoff, Evelyne

2014-01-01

The goal of the Advanced Clothing System (ACS) is to use advanced commercial off-the-shelf fibers and antimicrobial treatments with the goal of directly reducing the mass and volume of a logistics item. The current clothing state-of-the-art on the International Space Station (ISS) is disposable, mostly cotton-based, clothing with no laundry provisions. Each clothing article has varying use periods and will become trash. The goal is to increase the length of wear of the clothing to reduce the logistical mass and volume. The initial focus has been exercise clothing since the use period is lower. Various ground studies and an ISS technology demonstration have been conducted to evaluate clothing preference and length of wear. The analysis indicates that use of ACS selected garments (e.g. wool, modacrylic, polyester) can increase the breakeven point for laundry to 300 days.

Advanced Clothing System

NASA Technical Reports Server (NTRS)

Schlesinger, Thilini; Broyan, James; Orndoff, Evelyne

2014-01-01

The goal of the Advanced Clothing System (ACS) is to use advanced commercial off-theshelf fibers and antimicrobial treatments with the goal of directly reducing the mass and volume of a logistics item. The current clothing state-of-the-art on the International Space Station (ISS) is disposable, mostly cotton-based, clothing with no laundry provisions. Each clothing article has varying use periods and will become trash. The goal is to increase the length of wear of the clothing to reduce the logistical mass and volume. The initial focus has been exercise clothing since the use period is lower. Various ground studies and an ISS technology demonstration have been conducted to evaluate clothing preference and length of wear. The analysis indicates that use of ACS selected garments (e.g. wool, modacrylic, polyester) can increase the breakeven point for laundry to 300 days.

Containment system for experiments on radioactive and other hazardous materials in a Paris-Edinburgh press

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jacobsen, M. K., E-mail: mjacobsen@lanl.gov; Velisavljevic, N.

2015-11-15

Recent technical developments using the large volume Paris-Edinburgh press platform have enabled x-ray synchrotron studies at high pressure and temperature conditions. However, its application to some materials of interest, such as high hazard materials that require special handling due to safety issues, reactivity, or other challenges, has not been feasible without the introduction of special containment systems to eliminate the hazards. However, introduction of a containment system is challenging due to the requirement to provide full safety containment for operation in the variety of environments available, while not hindering any of the experimental probes that are available for inert samplemore » measurement. In this work, we report on the development and implementation of a full safety enclosure for a Paris-Edinburgh type press. During the initial development and subsequent application stage of work, experiments were performed on both cerium dioxide (CeO{sub 2}) and uranium (U). This device allows for full implementation of all currently available experimental probes involving the Paris-Edinburgh press at the High Pressure Collaborative Access Team sector of the Advanced Photon Source.« less

Advanced Mirror System Demonstrator (AMSD) Risk Management

NASA Technical Reports Server (NTRS)

Byberg, Alicia; Russell, J. Kevin; Kaukler, Donna; Burdine, Robert V. (Technical Monitor)

2002-01-01

This paper will report risk issues associated with designing, manufacturing, and testing the Advanced Mirror System Demonstrator (AMSD). The Advanced Mirror System Demonstrator (AMSD) will be developed as a lightweight primary mirror system that can be produced at a low cost and with a short manufacturing schedule. This technology will add to the knowledge base for selection for the Next Generation Space Telescope (NGST), Space Based Laser (SBL), Research Laboratory mission (AFRL), and other government agency programs.

Advanced flight control system study

NASA Technical Reports Server (NTRS)

Mcgough, J.; Moses, K.; Klafin, J. F.

1982-01-01

The architecture, requirements, and system elements of an ultrareliable, advanced flight control system are described. The basic criteria are functional reliability of 10 to the minus 10 power/hour of flight and only 6 month scheduled maintenance. A distributed system architecture is described, including a multiplexed communication system, reliable bus controller, the use of skewed sensor arrays, and actuator interfaces. Test bed and flight evaluation program are proposed.

Advanced Medical Technology and Network Systems Research.

DTIC Science & Technology

1999-09-01

for image-guided therapies . Advanced technologies included in this report are impedance imaging and a palpation training system. 14. SUBJECT...Summary 1 Virtual Clinic for Patients with Chronic Illness Project Planning Document • 2 Telemedicine for Hemodialysis 21 A...imaging systems and’ surgical procedures effort is accomplished in part by establishing the technology requirements for image-guided therapies . Advanced

Advanced energy system program

NASA Astrophysics Data System (ADS)

Trester, K.

1989-02-01

The objectives of the program are to design, develop and demonstrate a natural-gas-fueled, highly recuperated, 50 kW Brayton-cycle cogeneration system for commercial, institutional, and multifamily residential applications. Marketing studies have shown that this Advanced Energy System (AES), with its many unique and cost-effective features, has the potential to offer significant reductions in annual electrical and thermal energy costs to the consumer. Specific advantages of the system that result in low cost of ownership are high electrical efficiency (30 percent, HHV), low maintenance, high reliability and long life (20 years).

Research on advanced transportation systems

NASA Astrophysics Data System (ADS)

Nagai, Hirokazu; Hashimoto, Ryouhei; Nosaka, Masataka; Koyari, Yukio; Yamada, Yoshio; Noda, Keiichirou; Shinohara, Suetsugu; Itou, Tetsuichi; Etou, Takao; Kaneko, Yutaka

1992-08-01

An overview of the researches on advanced space transportation systems is presented. Conceptual study is conducted on fly back boosters with expendable upper stage rocket systems assuming a launch capacity of 30 tons and returning to the launch site by the boosters, and prospect of their feasibility is obtained. Reviews are conducted on subjects as follows: (1) trial production of 10 tons sub scale engines for the purpose of acquiring hardware data and picking up technical problems for full scale 100 tons thrust engines using hydrocarbon fuels; (2) development techniques for advanced liquid propulsion systems from the aspects of development schedule, cost; (3) review of conventional technologies, and common use of component; (4) oxidant switching propulsion systems focusing on feasibility of Liquefied Air Cycle Engine (LACE) and Compressed Air Cycle Engine (CACE); (5) present status of slosh hydrogen manufacturing, storage, and handling; (6) construction of small high speed dynamometer for promoting research on mini pump development; (7) hybrid solid boosters under research all over the world as low-cost and clean propulsion systems; and (8) high performance solid propellant for upper stage and lower stage propulsion systems.

Advanced downhole periodic seismic generator

DOEpatents

Hardee, Harry C.; Hills, Richard G.; Striker, Richard P.

1991-07-16

An advanced downhole periodic seismic generator system for transmitting variable frequency, predominantly shear-wave vibration into earth strata surrounding a borehole. The system comprises a unitary housing operably connected to a well head by support and electrical cabling and contains clamping apparatus for selectively clamping the housing to the walls of the borehole. The system further comprises a variable speed pneumatic oscillator and a self-contained pneumatic reservoir for producing a frequency-swept seismic output over a discrete frequency range.

Mass extraction container closure integrity physical testing method development for parenteral container closure systems.

PubMed

Yoon, Seung-Yil; Sagi, Hemi; Goldhammer, Craig; Li, Lei

2012-01-01

Container closure integrity (CCI) is a critical factor to ensure that product sterility is maintained over its entire shelf life. Assuring the CCI during container closure (C/C) system qualification, routine manufacturing and stability is important. FDA guidance also encourages industry to develop a CCI physical testing method in lieu of sterility testing in a stability program. A mass extraction system has been developed to check CCI for a variety of container closure systems such as vials, syringes, and cartridges. Various types of defects (e.g., glass micropipette, laser drill, wire) were created and used to demonstrate a detection limit. Leakage, detected as mass flow in this study, changes as a function of defect length and diameter. Therefore, the morphology of defects has been examined in detail with fluid theories. This study demonstrated that a mass extraction system was able to distinguish between intact samples and samples with 2 μm defects reliably when the defect was exposed to air, water, placebo, or drug product (3 mg/mL concentration) solution. Also, it has been verified that the method was robust, and capable of determining the acceptance limit using 3σ for syringes and 6σ for vials. Sterile products must maintain their sterility over their entire shelf life. Container closure systems such as those found in syringes and vials provide a seal between rubber and glass containers. This seal must be ensured to maintain product sterility. A mass extraction system has been developed to check container closure integrity for a variety of container closure systems such as vials, syringes, and cartridges. In order to demonstrate the method's capability, various types of defects (e.g., glass micropipette, laser drill, wire) were created in syringes and vials and were tested. This study demonstrated that a mass extraction system was able to distinguish between intact samples and samples with 2 μm defects reliably when the defect was exposed to air, water

Acoustic emission monitoring of composite containment systems

NASA Astrophysics Data System (ADS)

Maguire, John R.

2011-07-01

This paper considers two different types of composite containment system, and two different types of acoustic emission (AE) monitoring approach. The first system is a composite reinforced pressure vessel (CRPV) which is monitored both during construction and in-service using a broadband modal acoustic emission (MAE) technique. The second system is a membrane cargo containment system which is monitored using both a global as well as a local AE technique. For the CRPV, the damage assessment is concerned mainly with the integrity of the composite outer layer at the construction stage, and possible fatigue cracking of the inner steel liner at the in-service stage. For the membrane tank, the damage assessment is concerned with locating and quantifying any abnormal porosities that might develop in-service. By comparing and contrasting the different types of structural system and different monitoring approaches inferences are drawn as to what role AE monitoring could take in the damage assessment of other types of composite containment system. (Detailed technical data have not been included, due to client confidentiality constraints.)

Advanced transportation system studies. Technical area 2: Heavy lift launch vehicle development. Volume 2; Technical Results

NASA Technical Reports Server (NTRS)

1995-01-01

Sections 10 to 13 of the Advanced Transportation System Studies final report are included in this volume. Section 10 contains a copy of an executive summary that was prepared by Lockheed Space Operations Company (LSOC) to document their support to the TA-2 contract during the first-year period of performance of the contract, May 1992 through May 1993. LSOC participated on the TA-2 contract as part of the concurrent engineering launch system definition team, and provided outstanding heavy lift launch vehicle (HLLV) ground operations requirements and concept assessments for Lockheed Missiles and Space Company (LMSC) through an intercompany work transfer as well as providing specific HLLV ground operations assessments at the direction of NASA KSC through KSC funding that was routed to the TA-2 contract. Section 11 contains a copy of a vehicle-independent, launch system health management requirements assessment. The purpose of the assessment was to define both health management requirements and the associated interfaces between a generic advanced transportation system launch vehicle and all related elements of the entire transportation system, including the ground segment. Section 12 presents the major TA-2 presentations provided to summarize the significant results and conclusions that were developed over the course of the contract. Finally, Section 13 presents the design and assessment report on the first lunar outpost heavy lift launch vehicle.

Development Of Advanced Welding Control System

NASA Technical Reports Server (NTRS)

1990-01-01

Report describes development of next-generation control system for variable-polarity plasma arc (VPPA) welding. When fully developed, system expected to incorporate advanced sensors and adaptive control of position of and current in welding torch.

Advanced parking information system evaluation report

DOT National Transportation Integrated Search

1997-01-01

This report documents the evaluation analysis and results of the operational test. The evaluation assesses the impact/effect of the advance parking information system on the motoring public, parking facility operators, roadway system operations, and ...

"ATLAS" Advanced Technology Life-cycle Analysis System

NASA Technical Reports Server (NTRS)

Lollar, Louis F.; Mankins, John C.; ONeil, Daniel A.

2004-01-01

Making good decisions concerning research and development portfolios-and concerning the best systems concepts to pursue - as early as possible in the life cycle of advanced technologies is a key goal of R&D management This goal depends upon the effective integration of information from a wide variety of sources as well as focused, high-level analyses intended to inform such decisions Life-cycle Analysis System (ATLAS) methodology and tool kit. ATLAS encompasses a wide range of methods and tools. A key foundation for ATLAS is the NASA-created Technology Readiness. The toolkit is largely spreadsheet based (as of August 2003). This product is being funded by the Human and Robotics The presentation provides a summary of the Advanced Technology Level (TRL) systems Technology Program Office, Office of Exploration Systems, NASA Headquarters, Washington D.C. and is being integrated by Dan O Neil of the Advanced Projects Office, NASA/MSFC, Huntsville, AL

Installation of Computerized Procedure System and Advanced Alarm System in the Human Systems Simulation Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Le Blanc, Katya Lee; Spielman, Zachary Alexander; Rice, Brandon Charles

2016-04-01

This report describes the installation of two advanced control room technologies, an advanced alarm system and a computerized procedure system, into the Human Systems Simulation Laboratory (HSSL). Installation of these technologies enables future phases of this research by providing a platform to systematically evaluate the effect of these technologies on operator and plant performance.

Minimum Control Requirements for Advanced Life Support Systems

NASA Technical Reports Server (NTRS)

Boulange, Richard; Jones, Harry; Jones, Harry

2002-01-01

Advanced control technologies are not necessary for the safe, reliable and continuous operation of Advanced Life Support (ALS) systems. ALS systems can and are adequately controlled by simple, reliable, low-level methodologies and algorithms. The automation provided by advanced control technologies is claimed to decrease system mass and necessary crew time by reducing buffer size and minimizing crew involvement. In truth, these approaches increase control system complexity without clearly demonstrating an increase in reliability across the ALS system. Unless these systems are as reliable as the hardware they control, there is no savings to be had. A baseline ALS system is presented with the minimal control system required for its continuous safe reliable operation. This baseline control system uses simple algorithms and scheduling methodologies and relies on human intervention only in the event of failure of the redundant backup equipment. This ALS system architecture is designed for reliable operation, with minimal components and minimal control system complexity. The fundamental design precept followed is "If it isn't there, it can't fail".

Development of advanced fuel cell system, phase 3

NASA Technical Reports Server (NTRS)

Handley, L. M.; Meyer, A. P.; Bell, W. F.

1975-01-01

A multiple task research and development program was performed to improve the weight, life, and performance characteristics of hydrogen-oxygen alkaline fuel cells for advanced power systems. Gradual wetting of the anode structure and subsequent long-term performance loss was determined to be caused by deposition of a silicon-containing material on the anode. This deposit was attributed to degradation of the asbestos matrix, and attention was therefore placed on development of a substitute matrix of potassium titanate. An 80 percent gold 20 percent platinum catalyst cathode was developed which has the same performance and stability as the standard 90 percent gold - 10 percent platinum cathode but at half the loading. A hybrid polysulfone/epoxy-glass fiber frame was developed which combines the resistance to the cell environment of pure polysulfone with the fabricating ease of epoxy-glass fiber laminate. These cell components were evaluated in various configurations of full-size cells. The ways in which the baseline engineering model system would be modified to accommodate the requirements of the space tug application are identified.

The NASA Advanced Space Power Systems Project

NASA Technical Reports Server (NTRS)

Mercer, Carolyn R.; Hoberecht, Mark A.; Bennett, William R.; Lvovich, Vadim F.; Bugga, Ratnakumar

2015-01-01

The goal of the NASA Advanced Space Power Systems Project is to develop advanced, game changing technologies that will provide future NASA space exploration missions with safe, reliable, light weight and compact power generation and energy storage systems. The development effort is focused on maturing the technologies from a technology readiness level of approximately 23 to approximately 56 as defined in the NASA Procedural Requirement 7123.1B. Currently, the project is working on two critical technology areas: High specific energy batteries, and regenerative fuel cell systems with passive fluid management. Examples of target applications for these technologies are: extending the duration of extravehicular activities (EVA) with high specific energy and energy density batteries; providing reliable, long-life power for rovers with passive fuel cell and regenerative fuel cell systems that enable reduced system complexity. Recent results from the high energy battery and regenerative fuel cell technology development efforts will be presented. The technical approach, the key performance parameters and the technical results achieved to date in each of these new elements will be included. The Advanced Space Power Systems Project is part of the Game Changing Development Program under NASAs Space Technology Mission Directorate.

Advanced turbine blade tip seal system

NASA Technical Reports Server (NTRS)

Zelahy, J. W.

1981-01-01

An advanced blade/shroud system designed to maintain close clearance between blade tips and turbine shrouds and at the same time, be resistant to environmental effects including high temperature oxidation, hot corrosion, and thermal cycling is described. Increased efficiency and increased blade life are attained by using the advanced blade tip seal system. Features of the system include improved clearance control when blade tips preferentially wear the shrouds and a superior single crystal superalloy tip. The tip design, joint location, characterization of the single crystal tip alloy, the abrasive tip treatment, and the component and engine test are among the factors addressed. Results of wear testing, quality control plans, and the total manufacturing cycle required to fully process the blades are also discussed.

Advanced Traveler Information Systems (ATIS) 2.0 Precursor System: Final Report

DOT National Transportation Integrated Search

2018-03-01

Advanced Traveler Information Systems (ATIS) have experienced significant growth since their initial inception in the 1990s. Technologies have continued to evolve at a rapid pace, enabling the integration of advanced solutions for traveler informatio...

APTS : advanced public transportation systems program : technical assistance brief

DOT National Transportation Integrated Search

1993-01-01

Advanced Public Transportation Systems, or APTS, are advanced navigation and communication technologies applied to all aspects of public transportation system operations. APTS provides the technology for transportation agencies to make timely transit...

AEOSS runtime manual for system analysis on Advanced Earth-Orbital Spacecraft Systems

NASA Technical Reports Server (NTRS)

Lee, Hwa-Ping

1990-01-01

Advanced earth orbital spacecraft system (AEOSS) enables users to project the required power, weight, and cost for a generic earth-orbital spacecraft system. These variables are calculated on the component and subsystem levels, and then the system level. The included six subsystems are electric power, thermal control, structure, auxiliary propulsion, attitude control, and communication, command, and data handling. The costs are computed using statistically determined models that were derived from the flown spacecraft in the past and were categorized into classes according to their functions and structural complexity. Selected design and performance analyses for essential components and subsystems are also provided. AEOSS has the feature permitting a user to enter known values of these parameters, totally and partially, at all levels. All information is of vital importance to project managers of subsystems or a spacecraft system. AEOSS is a specially tailored software coded from the relational database program of the Acius' 4th Dimension with a Macintosh version. Because of the licensing agreements, two versions of the AEOSS documents were prepared. This version, AEOSS Runtime Manual, is permitted to be distributed with a finite number of the restrictive 4D Runtime version. It can perform all contained applications without any programming alterations.

Advances in Solar Heating and Cooling Systems

ERIC Educational Resources Information Center

Ward, Dan S.

1976-01-01

Reports on technological advancements in the fields of solar collectors, thermal storage systems, and solar heating and cooling systems. Diagrams aid in the understanding of the thermodynamics of the systems. (CP)

Advanced spacecraft fuel cell systems

NASA Technical Reports Server (NTRS)

Thaller, L. H.

1972-01-01

The development and characteristics of advanced spacecraft fuel cell systems are discussed. The system is designed to operate on low pressure, propulsion grade hydrogen and oxygen. The specific goals are 10,000 hours of operation with refurbishment, 20 pounds per kilowatt at a sustained power of 7 KW, and 21 KW peaking capability for durations of two hours. The system rejects waste heat to the spacecraft cooling system at power levels up to 7 KW. At higher powers, the system automatically transfers to open cycle operation with overboard steam venting.

Advanced turboprop testbed systems study

NASA Technical Reports Server (NTRS)

Goldsmith, I. M.

1982-01-01

The proof of concept, feasibility, and verification of the advanced prop fan and of the integrated advanced prop fan aircraft are established. The use of existing hardware is compatible with having a successfully expedited testbed ready for flight. A prop fan testbed aircraft is definitely feasible and necessary for verification of prop fan/prop fan aircraft integrity. The Allison T701 is most suitable as a propulsor and modification of existing engine and propeller controls are adequate for the testbed. The airframer is considered the logical overall systems integrator of the testbed program.

Advanced Space Fission Propulsion Systems

NASA Technical Reports Server (NTRS)

Houts, Michael G.; Borowski, Stanley K.

2010-01-01

Fission has been considered for in-space propulsion since the 1940s. Nuclear Thermal Propulsion (NTP) systems underwent extensive development from 1955-1973, completing 20 full power ground tests and achieving specific impulses nearly twice that of the best chemical propulsion systems. Space fission power systems (which may eventually enable Nuclear Electric Propulsion) have been flown in space by both the United States and the Former Soviet Union. Fission is the most developed and understood of the nuclear propulsion options (e.g. fission, fusion, antimatter, etc.), and fission has enjoyed tremendous terrestrial success for nearly 7 decades. Current space nuclear research and technology efforts are focused on devising and developing first generation systems that are safe, reliable and affordable. For propulsion, the focus is on nuclear thermal rockets that build on technologies and systems developed and tested under the Rover/NERVA and related programs from the Apollo era. NTP Affordability is achieved through use of previously developed fuels and materials, modern analytical techniques and test strategies, and development of a small engine for ground and flight technology demonstration. Initial NTP systems will be capable of achieving an Isp of 900 s at a relatively high thrust-to-weight ratio. The development and use of first generation space fission power and propulsion systems will provide new, game changing capabilities for NASA. In addition, development and use of these systems will provide the foundation for developing extremely advanced power and propulsion systems capable of routinely and affordably accessing any point in the solar system. The energy density of fissile fuel (8 x 10(exp 13) Joules/kg) is more than adequate for enabling extensive exploration and utilization of the solar system. For space fission propulsion systems, the key is converting the virtually unlimited energy of fission into thrust at the desired specific impulse and thrust

Advanced public transportation systems : evaluation guidelines

DOT National Transportation Integrated Search

1994-01-01

The Federal Transit Administration has developed the Advanced Public Transportation Systems (APTS) Program which is an integral part of the overall U.S. DOT Intelligent Vehicle Highway Systems (IVHS) effort. A major aim of the APTS Program is to prom...

APPLICATION OF A GEOGRAPHIC INFORMATION SYSTEM FOR A CONTAINMENT SYSTEM LEAK DETECTION

EPA Science Inventory

The use of physical and hydraulic containment systems for the isolation of contaminated ground water associated with hazardous waste sites has increased during the last decade. Existing methodologies for monitoring and evaluating leakage from hazardous waste containment systems ...

Containment system for experiments on radioactive and other hazardous materials in a Paris-Edinburgh press

DOE PAGES

Jacobsen, M. K.; Velisavljevic, N.

2015-11-20

Recent technical developments using the large volume Paris-Edinburgh press platform have enabled x-ray synchrotron studies at high pressure and temperature conditions. However, its application to some materials of interest, such as high hazard materials that require special handling due to safety issues, reactivity, or other challenges, has not been feasible without the introduction of special containment systems to eliminate the hazards. However, introduction of a containment system is challenging due to the requirement to provide full safety containment for operation in the variety of environments available, while not hindering any of the experimental probes that are available for inert samplemore » measurement. In this work, we report on the development and implementation of a full safety enclosure for a Paris-Edinburgh type press. During the initial development and subsequent application stage of work, experiments were performed on both cerium dioxide (CeO2) and uranium (U). As a result, this device allows for full implementation of all currently available experimental probes involving the Paris-Edinburgh press at the High Pressure Collaborative Access Team sector of the Advanced Photon Source.« less

Advanced photovoltaic power system technology for lunar base applications

NASA Astrophysics Data System (ADS)

Brinker, David J.; Flood, Dennis J.

1992-09-01

The development of an advanced photovoltaic power system that would have application for a manned lunar base is currently planned under the Surface Power element of Pathfinder. Significant mass savings over state-of-the-art photovoltaic/battery systems are possible with the use of advanced lightweight solar arrays coupled with regenerative fuel cell storage. The solar blanket, using either ultrathin GaAs or amorphous silicon solar cells, would be integrated with a reduced-g structure. Regenerative fuel cells with high-pressure gas storage in filament-wound tanks are planned for energy storage. An advanced PV/RFC power system is a leading candidate for a manned lunar base as it offers a tremendous weight advantage over state-of-the-art photovoltaic/battery systems and is comparable in mass to other advanced power generation technologies.

Advanced Teleprocessing Systems

DTIC Science & Technology

1983-09-30

Defenae AdTanced Research Projects Agency DAHC1S.C0368 DARPA rw M n*~ MDA 903.77.C-0272 A ^^ ^ 2490 MDA «)W3-C-0064 COMPUTER NETWORK...i -.% W-V."’ * - \\ ATV.VVV" ir*7 ADVANCED TELEPROCESSING SYSTEMS Semi-Annual Technical Report September 30, 1983 Contract Number: MDA 903-82...83 through 30 SEPT 83 6 PERFORMING ORG. REPORT NUMBER 7. AUTHORC«; Leonard Kleinrock 8 CONTRACT OR GRANT NUMBERr«; MDA 903-82-C-0064 9

A survey of advanced battery systems for space applications

NASA Technical Reports Server (NTRS)

Attia, Alan I.

1989-01-01

The results of a survey on advanced secondary battery systems for space applications are presented. The objectives were: to identify advanced battery systems capable of meeting the requirements of various types of space missions, with significant advantages over currently available batteries, to obtain an accurate estimate of the anticipated improvements of these advanced systems, and to obtain a consensus for the selection of systems most likely to yield the desired improvements. Few advanced systems are likely to exceed a specific energy of 150 Wh/kg and meet the additional requirements of safety and reliability within the next 15 years. The few that have this potential are: (1) regenerative fuel cells, both alkaline and solid polymer electrolyte (SPE) types for large power systems; (2) lithium-intercalatable cathodes, particularly the metal ozides intercalatable cathodes (MnO2 or CoO2), with applications limited to small spacecrafts requiring limited cycle life and low power levels; (3) lithium molten salt systems (e.g., LiAl-FeS2); and (4) Na/beta Alumina/Sulfur or metal chlorides cells. Likely technological advances that would enhance the performance of all the above systems are also identified, in particular: improved bifunctional oxygen electrodes; improved manufacturing technology for thin film lithium electrodes in combination with polymeric electrolytes; improved seals for the lithium molten salt cells; and improved ceramics for sodium/solid electrolyte cells.

Intermittent patient suction system, self-contained control

DOEpatents

Lewis, Jay L.

1992-01-01

An intermittent patient suction system, a self-contained control device therefor and methods of making the same are provided, the self-contained control device having a housing that contains two restrictor units therein for respectively controlling the "on" time and "off" time that the control device applies a vacuum and does not apply a vacuum through the output of the control device to the patient.

Advanced uncooled infrared system electronics

NASA Astrophysics Data System (ADS)

Neal, Henry W.

1998-07-01

Over the past two decades, Raytheon Systems Company (RSC), formerly Texas Instruments Defense Systems & Electronics Group, developed a robust family of products based on a low- cost, hybrid ferroelectric (FE) uncooled focal-plane array (FPA) aimed at meeting the needs for thermal imaging products across both military and commercial markets. Over the years, RSC supplied uncooled infrared (IR) sensors for applications such as in combat vehicles, man-portable weaponry, personnel helmets, and installation security. Also, various commercial IR systems for use in automobiles, boats, law enforcement, hand-held applications, building/site security, and fire fighting have been developed. These products resulted in a high degree of success where cooled IR platforms are too bulky and costly, and other uncooled implementations are less reliable or lack significant cost advantage. Proof of this great success is found in the large price reductions, the unprecedented monthly production rates, and the wide diversity of products and customers realized in recent years. The ever- changing needs of these existing and potential customers continue to fuel the advancement of both the primary technologies and the production capabilities of uncooled IR systems at RSC. This paper will describe a development project intended to further advance the system electronics capabilities of future uncooled IR products.

Advanced EVA system design requirements study

NASA Technical Reports Server (NTRS)

1986-01-01

Design requirements and criteria for the Space Station Advanced Extravehicular Activity System (EVAS) including crew enclosures, portable life support systems, maneuvering propulsion systems, and related extravehicular activity (EVA) support equipment were defined and established. The EVA mission requirements, environments, and medical and physiological requirements, as well as opertional, procedures, and training issues were considered.

Advanced Information Processing System (AIPS)

NASA Technical Reports Server (NTRS)

Pitts, Felix L.

1993-01-01

Advanced Information Processing System (AIPS) is a computer systems philosophy, a set of validated hardware building blocks, and a set of validated services as embodied in system software. The goal of AIPS is to provide the knowledgebase which will allow achievement of validated fault-tolerant distributed computer system architectures, suitable for a broad range of applications, having failure probability requirements of 10E-9 at 10 hours. A background and description is given followed by program accomplishments, the current focus, applications, technology transfer, FY92 accomplishments, and funding.

NASA Advanced Explorations Systems: Advancements in Life Support Systems

NASA Technical Reports Server (NTRS)

Shull, Sarah A.; Schneider, Walter F.

2016-01-01

The NASA Advanced Exploration Systems (AES) Life Support Systems (LSS) project strives to develop reliable, energy-efficient, and low-mass spacecraft systems to provide environmental control and life support systems (ECLSS) critical to enabling long duration human missions beyond low Earth orbit (LEO). Highly reliable, closed-loop life support systems are among the capabilities required for the longer duration human space exploration missions assessed by NASA's Habitability Architecture Team (HAT). The LSS project is focused on four areas: architecture and systems engineering for life support systems, environmental monitoring, air revitalization, and wastewater processing and water management. Starting with the international space station (ISS) LSS systems as a point of departure (where applicable), the mission of the LSS project is three-fold: 1. Address discrete LSS technology gaps 2. Improve the reliability of LSS systems 3. Advance LSS systems towards integrated testing on the ISS. This paper summarized the work being done in the four areas listed above to meet these objectives. Details will be given on the following focus areas: Systems Engineering and Architecture- With so many complex systems comprising life support in space, it is important to understand the overall system requirements to define life support system architectures for different space mission classes, ensure that all the components integrate well together and verify that testing is as representative of destination environments as possible. Environmental Monitoring- In an enclosed spacecraft that is constantly operating complex machinery for its own basic functionality as well as science experiments and technology demonstrations, it's possible for the environment to become compromised. While current environmental monitors aboard the ISS will alert crew members and mission control if there is an emergency, long-duration environmental monitoring cannot be done in-orbit as current methodologies

Advances in mechanisms of systemic lupus erythematosus.

PubMed

Dema, Barbara; Charles, Nicolas

2014-05-01

Systemic lupus erythematosus (SLE) is a complex autoimmune disease associated with hormonal, environmental, and genetic factors and linked to the tolerance breakdown of B and T cells to self-antigens. SLE is characterized by the presence in patient serum of autoantibodies raised against nuclear components. Association of these antibodies to self-antigens, complement factors, DNA, and particular proteins will form circulating immune complexes (CIC) which can deposit in several organs, causing tissue damage and clinical manifestations. Historically, SLE is considered as an adaptive immune system disorder. Over the past decade, advances in the understanding of SLE pathogenesis placed the innate immune system as a key player in perpetuating and amplifying this systemic disease. In this review, we summarize some recent key advances in understanding the SLE immune-pathogenesis with a particular focus on newly discovered key factors from the innate immune system and how they influence the pathogenic adaptive immune system: neutrophils and neutrophil extracellular traps (NETs), plasmacytoid dendritic cells (pDCs) and type I interferons, basophils and autoreactive IgE, monocytes/macrophages and the inflammasome. Recent advances on B and T cell involvement in the SLE pathogenesis mechanisms are also discussed. Although the disease is clinically, genetically, and immunologically heterogeneous between affected individuals, the latest discoveries are offering new promising therapeutic strategies.

Benefits assessment of advanced public transportation systems (APTS)

DOT National Transportation Integrated Search

1996-07-01

This report documents work performed under FTA's Advance Public Transportation Systems (APTS) Program, a program structured to undertake research and development of innovative applications of advanced navigation, information, and communication techno...

The Advanced National Seismic System; management and implementation

USGS Publications Warehouse

Benz, H.M.; Shedlock, K.M.; Buland, R.P.

2001-01-01

What is the Advanced National Seismic System? The Advanced National Seismic System (ANSS) is designed to organize, modernize, and standardize operations of seismic networks in the United States to improve the Nation’s ability to respond effectively to damaging earthquakes, volcanoes, and tsunamis. To achieve this, the ANSS will link more than 7,000 national, regional and urban monitoring stations in real time

Advanced Launch System advanced development oxidizer turbopump program: Technical implementation plan

NASA Technical Reports Server (NTRS)

Ferlita, F.

1989-01-01

The Advanced Launch Systems (ALS) Advanced Development Oxidizer Turbopump Program has designed, fabricated and demonstrated a low cost, highly reliable oxidizer turbopump for the Space Transportation Engine that minimizes the recurring cost for the ALS engines. Pratt and Whitney's (P and W's) plan for integrating the analyses, testing, fabrication, and other program efforts is addressed. This plan offers a comprehensive description of the total effort required to design, fabricate, and test the ALS oxidizer turbopump. The proposed ALS oxidizer turbopump reduces turbopump costs over current designs by taking advantage of design simplicity and state-of-the-art materials and producibility features without compromising system reliability. This is accomplished by selecting turbopump operating conditions that are within known successful operating regions and by using proven manufacturing techniques.

Engineered containment and control systems: nurturing nature.

PubMed

Clarke, James H; MacDonell, Margaret M; Smith, Ellen D; Dunn, R Jeffrey; Waugh, W Jody

2004-06-01

The development of engineered containment and control systems for contaminated sites must consider the environmental setting of each site. The behaviors of both contaminated materials and engineered systems are affected by environmental conditions that will continue to evolve over time as a result of such natural processes as climate change, ecological succession, pedogenesis, and landform changes. Understanding these processes is crucial to designing, implementing, and maintaining effective systems for sustained health and environmental protection. Traditional engineered systems such as landfill liners and caps are designed to resist natural processes rather than working with them. These systems cannot be expected to provide long-term isolation without continued maintenance. In some cases, full-scale replacement and remediation may be required within 50 years, at an effort and cost much higher than for the original cleanup. Approaches are being developed to define smarter containment and control systems for stewardship sites, considering lessons learned from implementing prescriptive waste disposal regulations enacted since the 1970s. These approaches more effectively involve integrating natural and engineered systems; enhancing sensors and predictive tools for evaluating performance; and incorporating information on failure events, including precursors and consequences, into system design and maintenance. An important feature is using natural analogs to predict environmental conditions and system responses over the long term, to accommodate environmental change in the design process, and, as possible, to engineer containment systems that mimic favorable natural systems. The key emphasis is harmony with the environment, so systems will work with and rely on natural processes rather than resisting them. Implementing these new integrated systems will reduce current requirements for active management, which are resource-intensive and expensive.

Advanced Technology System Scheduling Governance Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ang, Jim; Carnes, Brian; Hoang, Thuc

In the fall of 2005, the Advanced Simulation and Computing (ASC) Program appointed a team to formulate a governance model for allocating resources and scheduling the stockpile stewardship workload on ASC capability systems. This update to the original document takes into account the new technical challenges and roles for advanced technology (AT) systems and the new ASC Program workload categories that must be supported. The goal of this updated model is to effectively allocate and schedule AT computing resources among all three National Nuclear Security Administration (NNSA) laboratories for weapons deliverables that merit priority on this class of resource. Themore » process outlined below describes how proposed work can be evaluated and approved for resource allocations while preserving high effective utilization of the systems. This approach will provide the broadest possible benefit to the Stockpile Stewardship Program (SSP).« less

High-Purity Aluminum Magnet Technology for Advanced Space Transportation Systems

NASA Technical Reports Server (NTRS)

Goodrich, R. G.; Pullam, B.; Rickle, D.; Litchford, R. J.; Robertson, G. A.; Schmidt, D. D.; Cole, John (Technical Monitor)

2001-01-01

Basic research on advanced plasma-based propulsion systems is routinely focused on plasmadynamics, performance, and efficiency aspects while relegating the development of critical enabling technologies, such as flight-weight magnets, to follow-on development work. Unfortunately, the low technology readiness levels (TRLs) associated with critical enabling technologies tend to be perceived as an indicator of high technical risk, and this, in turn, hampers the acceptance of advanced system architectures for flight development. Consequently, there is growing recognition that applied research on the critical enabling technologies needs to be conducted hand in hand with basic research activities. The development of flight-weight magnet technology, for example, is one area of applied research having broad crosscutting applications to a number of advanced propulsion system architectures. Therefore, NASA Marshall Space Flight Center, Louisiana State University (LSU), and the National High Magnetic Field Laboratory (NHMFL) have initiated an applied research project aimed at advancing the TRL of flight-weight magnets. This Technical Publication reports on the group's initial effort to demonstrate the feasibility of cryogenic high-purity aluminum magnet technology and describes the design, construction, and testing of a 6-in-diameter by 12-in-long aluminum solenoid magnet. The coil was constructed in the machine shop of the Department of Physics and Astronomy at LSU and testing was conducted in NHMFL facilities at Florida State University and at Los Alamos National Laboratory. The solenoid magnet was first wound, reinforced, potted in high thermal conductivity epoxy, and bench tested in the LSU laboratories. A cryogenic container for operation at 77 K was also constructed and mated to the solenoid. The coil was then taken to NHMFL facilities in Tallahassee, FL. where its magnetoresistance was measured in a 77 K environment under steady magnetic fields as high as 10 T. In

Evaluation of mobility impacts of advanced information systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peeta, S.; Poonuru, K.; Sinha, K.

2000-06-01

Advanced technologies under the aegis of advanced traveler information systems and advanced traffic management systems are being employed to address the debilitating traffic congestion problem. Broadly identified under the label intelligent transportation systems (ITS), they focus on enhancing the efficiency of the existing roadway utilization. Though ITS has transitioned from the conceptual framework stage to the operational test phase that analyzes real-world feasibility, studies that systematically quantify the multidimensional real-world impacts of these technologies in terms of mobility, safety, and air quality, are lacking. This paper proposes a simulation-based framework to address the mobility impacts of these technologies through themore » provision of information to travelers. The information provision technologies are labeled as advanced information systems (AIS), and include pretrip information, en route information, variable message signs, and combinations thereof. The primary focus of the paper is to evaluate alternative AIS technologies using the heavily traveled Borman Expressway corridor in northwestern Indiana as a case study. Simulation results provide insights into the mobility impacts of AIS technologies, and contrast the effectiveness of alternative information provision sources and strategies.« less

Study of advanced fuel system concepts for commercial aircraft

NASA Technical Reports Server (NTRS)

Coffinberry, G. A.

1985-01-01

An analytical study was performed in order to assess relative performance and economic factors involved with alternative advanced fuel systems for future commercial aircraft operating with broadened property fuels. The DC-10-30 wide-body tri-jet aircraft and the CF6-8OX engine were used as a baseline design for the study. Three advanced systems were considered and were specifically aimed at addressing freezing point, thermal stability and lubricity fuel properties. Actual DC-10-30 routes and flight profiles were simulated by computer modeling and resulted in prediction of aircraft and engine fuel system temperatures during a nominal flight and during statistical one-day-per-year cold and hot flights. Emergency conditions were also evaluated. Fuel consumption and weight and power extraction results were obtained. An economic analysis was performed for new aircraft and systems. Advanced system means for fuel tank heating included fuel recirculation loops using engine lube heat and generator heat. Environmental control system bleed air heat was used for tank heating in a water recirculation loop. The results showed that fundamentally all of the three advanced systems are feasible but vary in their degree of compatibility with broadened-property fuel.

System reliability approaches for advanced propulsion system structures

NASA Technical Reports Server (NTRS)

Cruse, T. A.; Mahadevan, S.

1991-01-01

This paper identifies significant issues that pertain to the estimation and use of system reliability in the design of advanced propulsion system structures. Linkages between the reliabilities of individual components and their effect on system design issues such as performance, cost, availability, and certification are examined. The need for system reliability computation to address the continuum nature of propulsion system structures and synergistic progressive damage modes has been highlighted. Available system reliability models are observed to apply only to discrete systems. Therefore a sequential structural reanalysis procedure is formulated to rigorously compute the conditional dependencies between various failure modes. The method is developed in a manner that supports both top-down and bottom-up analyses in system reliability.

Design of Advanced Atmospheric Water Vapor Differential Absorption Lidar (DIAL) Detection System

NASA Technical Reports Server (NTRS)

Refaat, Tamer F.; Luck, William S., Jr.; DeYoung, Russell J.

1999-01-01

The measurement of atmospheric water vapor is very important for understanding the Earth's climate and water cycle. The lidar atmospheric sensing experiment (LASE) is an instrument designed and operated by the Langley Research Center for high precision water vapor measurements. The design details of a new water vapor lidar detection system that improves the measurement sensitivity of the LASE instrument by a factor of 10 are discussed. The new system consists of an advanced, very low noise, avalanche photodiode (APD) and a state-of-the-art signal processing circuit. The new low-power system is also compact and lightweight so that it would be suitable for space flight and unpiloted atmospheric vehicles (UAV) applications. The whole system is contained on one small printed circuit board (9 x 15 sq cm). The detection system is mounted at the focal plane of a lidar receiver telescope, and the digital output is read by a personal computer with a digital data acquisition card.

Advanced Active Thermal Control Systems Architecture Study

NASA Technical Reports Server (NTRS)

Hanford, Anthony J.; Ewert, Michael K.

1996-01-01

The Johnson Space Center (JSC) initiated a dynamic study to determine possible improvements available through advanced technologies (not used on previous or current human vehicles), identify promising development initiatives for advanced active thermal control systems (ATCS's), and help prioritize funding and personnel distribution among many research projects by providing a common basis to compare several diverse technologies. Some technologies included were two-phase thermal control systems, light-weight radiators, phase-change thermal storage, rotary fluid coupler, and heat pumps. JSC designed the study to estimate potential benefits from these various proposed and under-development thermal control technologies for five possible human missions early in the next century. The study compared all the technologies to a baseline mission using mass as a basis. Each baseline mission assumed an internal thermal control system; an external thermal control system; and aluminum, flow-through radiators. Solar vapor compression heat pumps and light-weight radiators showed the greatest promise as general advanced thermal technologies which can be applied across a range of missions. This initial study identified several other promising ATCS technologies which offer mass savings and other savings compared to traditional thermal control systems. Because the study format compares various architectures with a commonly defined baseline, it is versatile and expandable, and is expected to be updated as needed.

Advanced tracking systems design and analysis

NASA Technical Reports Server (NTRS)

Potash, R.; Floyd, L.; Jacobsen, A.; Cunningham, K.; Kapoor, A.; Kwadrat, C.; Radel, J.; Mccarthy, J.

1989-01-01

The results of an assessment of several types of high-accuracy tracking systems proposed to track the spacecraft in the National Aeronautics and Space Administration (NASA) Advanced Tracking and Data Relay Satellite System (ATDRSS) are summarized. Tracking systems based on the use of interferometry and ranging are investigated. For each system, the top-level system design and operations concept are provided. A comparative system assessment is presented in terms of orbit determination performance, ATDRSS impacts, life-cycle cost, and technological risk.

Advanced Autonomous Systems for Space Operations

NASA Astrophysics Data System (ADS)

Gross, A. R.; Smith, B. D.; Muscettola, N.; Barrett, A.; Mjolssness, E.; Clancy, D. J.

2002-01-01

New missions of exploration and space operations will require unprecedented levels of autonomy to successfully accomplish their objectives. Inherently high levels of complexity, cost, and communication distances will preclude the degree of human involvement common to current and previous space flight missions. With exponentially increasing capabilities of computer hardware and software, including networks and communication systems, a new balance of work is being developed between humans and machines. This new balance holds the promise of not only meeting the greatly increased space exploration requirements, but simultaneously dramatically reducing the design, development, test, and operating costs. New information technologies, which take advantage of knowledge-based software, model-based reasoning, and high performance computer systems, will enable the development of a new generation of design and development tools, schedulers, and vehicle and system health management capabilities. Such tools will provide a degree of machine intelligence and associated autonomy that has previously been unavailable. These capabilities are critical to the future of advanced space operations, since the science and operational requirements specified by such missions, as well as the budgetary constraints will limit the current practice of monitoring and controlling missions by a standing army of ground-based controllers. System autonomy capabilities have made great strides in recent years, for both ground and space flight applications. Autonomous systems have flown on advanced spacecraft, providing new levels of spacecraft capability and mission safety. Such on-board systems operate by utilizing model-based reasoning that provides the capability to work from high-level mission goals, while deriving the detailed system commands internally, rather than having to have such commands transmitted from Earth. This enables missions of such complexity and communication` distances as are not

Smart container UWB sensor system for situational awareness of intrusion alarms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romero, Carlos E.; Haugen, Peter C.; Zumstein, James M.

An in-container monitoring sensor system is based on an UWB radar intrusion detector positioned in a container and having a range gate set to the farthest wall of the container from the detector. Multipath reflections within the container make every point on or in the container appear to be at the range gate, allowing intrusion detection anywhere in the container. The system also includes other sensors to provide false alarm discrimination, and may include other sensors to monitor other parameters, e.g. radiation. The sensor system also includes a control subsystem for controlling system operation. Communications and information extraction capability maymore » also be included. A method of detecting intrusion into a container uses UWB radar, and may also include false alarm discrimination. A secure container has an UWB based monitoring system« less

Subsurface materials management and containment system

DOEpatents

Nickelson, Reva A.; Richardson, John G.; Kosteinik, Kevin M.; Sloan, Paul A.

2004-07-06

Systems, components, and methods relating to subterranean containment barriers. Laterally adjacent tubular casings having male interlock structures and multiple female interlock structures defining recesses for receiving a male interlock structure are used to create subterranean barriers for containing and treating buried waste and its effluents. The multiple female interlock structures enable the barriers to be varied around subsurface objects and to form barrier sidewalls. The barrier may be used for treating and monitoring a zone of interest.

Subsurface materials management and containment system

DOEpatents

Nickelson, Reva A.; Richardson, John G.; Kostelnik, Kevin M.; Sloan, Paul A.

2006-10-17

Systems, components, and methods relating to subterranean containment barriers. Laterally adjacent tubular casings having male interlock structures and multiple female interlock structures defining recesses for receiving a male interlock structure are used to create subterranean barriers for containing and treating buried waste and its effluents. The multiple female interlock structures enable the barriers to be varied around subsurface objects and to form barrier sidewalls. The barrier may be used for treating and monitoring a zone of interest.

Development of advanced fuel cell system, phase 2

NASA Technical Reports Server (NTRS)

Handley, L. M.; Meyer, A. P.; Bell, W. F.

1973-01-01

A multiple task research and development program was performed to improve the weight, life, and performance characteristics of hydrogen-oxygen alkaline fuel cells for advanced power systems. Development and characterization of a very stable gold alloy catalyst was continued from Phase I of the program. A polymer material for fabrication of cell structural components was identified and its long term compatibility with the fuel cell environment was demonstrated in cell tests. Full scale partial cell stacks, with advanced design closed cycle evaporative coolers, were tested. The characteristics demonstrated in these tests verified the feasibility of developing the engineering model system concept into an advanced lightweight long life powerplant.

Spectroradiometric considerations for advanced land observing systems

NASA Technical Reports Server (NTRS)

Slater, P. N.

1986-01-01

Research aimed at improving the inflight absolute radiometric calibration of advanced land observing systems was initiated. Emphasis was on the satellite sensor calibration program at White Sands. Topics addressed include: absolute radiometric calibration of advanced remote sensing; atmospheric effects on reflected radiation; inflight radiometric calibration; field radiometric methods for reflectance and atmospheric measurement; and calibration of field relectance radiometers.

System architecture for an advanced Canadian communications satellite demonstration mission

NASA Astrophysics Data System (ADS)

Takats, P.; Irani, S.

1992-03-01

An advanced communications satellite system that provides single hop interconnectivity and interworking for both a personal communications network and an advanced private business network in the Ka and Ku bands respectively, is presented. An overall network perspective is discussed that studies the interface of such an advanced satellite communication system to the terrestrial network in the context of the Open Systems Interconnection model. It is shown that this proposed satellite system can dynamically establish links and efficiently allocate the satellite resource amongst the user terminal population for a mix of data and voice traffic.

Systems study of transport aircraft incorporating advanced aluminum alloys

NASA Technical Reports Server (NTRS)

Sakata, I. F.

1982-01-01

A study was performed to quantify the potential benefits of utilizing advanced aluminum alloys in commercial transport aircraft and to define the effort necessary to develop fully the alloys to a viable commercial production capability. The comprehensive investigation (1) established realistic advanced aluminum alloy property goals to maximize aircraft systems effectiveness (2) identified performance and economic benefits of incorporating the advanced alloy in future advanced technology commercial aircraft designs (3) provided a recommended plan for development and integration of the alloys into commercial aircraft production (4) provided an indication of the timing and investigation required by the metal producing industry to support the projected market and (5) evaluate application of advanced aluminum alloys to other aerospace and transit systems as a secondary objective. The results of the investigation provided a roadmap and identified key issues requiring attention in an advanced aluminum alloy and applications technology development program.

Advanced Atmospheric Water Vapor DIAL Detection System

NASA Technical Reports Server (NTRS)

Refaat, Tamer F.; Elsayed-Ali, Hani E.; DeYoung, Russell J. (Technical Monitor)

2000-01-01

Measurement of atmospheric water vapor is very important for understanding the Earth's climate and water cycle. The remote sensing Differential Absorption Lidar (DIAL) technique is a powerful method to perform such measurement from aircraft and space. This thesis describes a new advanced detection system, which incorporates major improvements regarding sensitivity and size. These improvements include a low noise advanced avalanche photodiode detector, a custom analog circuit, a 14-bit digitizer, a microcontroller for on board averaging and finally a fast computer interface. This thesis describes the design and validation of this new water vapor DIAL detection system which was integrated onto a small Printed Circuit Board (PCB) with minimal weight and power consumption. Comparing its measurements to an existing DIAL system for aerosol and water vapor profiling validated the detection system.

Deploying advanced public transportation systems in Birmingham

DOT National Transportation Integrated Search

2003-08-01

Advanced Public Transportation Systems (APTS) technologies have been deployed by many urban transit systems in order to improve efficiency, reduce operating costs, and improve service quality. The majority of : these deployments, however, have been i...

Self-Contained Automated Vehicle Washing System

DTIC Science & Technology

2014-09-26

SECURITY CLASSIFICATION OF: The Self Contained Automated Vehicle Washing System is a prototype that offers a reduction in the quantity of water ...supplied to the front lines by recycling wash water used in the cleaning of vehicles as well as capturing debris and other contaminates. The system also...of the warfighter to contaminates in the washing process. The System offers plug and play option for reclamation of the wash water and integration of

Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice.

PubMed

Ustun, Celalettin; Arock, Michel; Kluin-Nelemans, Hanneke C; Reiter, Andreas; Sperr, Wolfgang R; George, Tracy; Horny, Hans-Peter; Hartmann, Karin; Sotlar, Karl; Damaj, Gandhi; Hermine, Olivier; Verstovsek, Srdan; Metcalfe, Dean D; Gotlib, Jason; Akin, Cem; Valent, Peter

2016-10-01

Systemic mastocytosis is a heterogeneous disease characterized by the accumulation of neoplastic mast cells in the bone marrow and other organ organs/tissues. Mutations in KIT, most frequently KIT D816V, are detected in over 80% of all systemic mastocytosis patients. While most systemic mastocytosis patients suffer from an indolent disease variant, some present with more aggressive variants, collectively called "advanced systemic mastocytosis", which include aggressive systemic mastocytosis, systemic mastocytosis with an associated hematologic, clonal non mast cell-lineage disease, and mast cell leukemia. Whereas patients with indolent systemic mastocytosis have a near normal life expectancy, patients with advanced systemic mastocytosis have a reduced life expectancy. Although cladribine and interferon-alpha are of benefit in a group of patients with advanced systemic mastocytosis, no curative therapy is available for these patients except possible allogeneic hematopoietic stem cell transplantation. Recent studies have also revealed additional somatic defects (apart from mutations in KIT) in a majority of patients with advanced systemic mastocytosis. These include TET2, SRSF2, ASXL1, RUNX1, JAK2, and/or RAS mutations, which may adversely impact prognosis and survival in particular systemic mastocytosis with an associated hematological neoplasm. In addition, several additional signaling molecules involved in the abnormal proliferation of mast cells in systemic mastocytosis have been identified. These advances have led to a better understanding of the biology of advanced systemic mastocytosis and to the development of new targeted treatment concepts. Herein, we review the biology and pathogenesis of advanced systemic mastocytosis, with a special focus on novel molecular findings as well as current and evolving therapeutic options. Copyright© Ferrata Storti Foundation.

Intelligent Engine Systems: Thermal Management and Advanced Cooling

NASA Technical Reports Server (NTRS)

Bergholz, Robert

2008-01-01

The objective of the Advanced Turbine Cooling and Thermal Management program is to develop intelligent control and distribution methods for turbine cooling, while achieving a reduction in total cooling flow and assuring acceptable turbine component safety and reliability. The program also will develop embedded sensor technologies and cooling system models for real-time engine diagnostics and health management. Both active and passive control strategies will be investigated that include the capability of intelligent modulation of flow quantities, pressures, and temperatures both within the supply system and at the turbine component level. Thermal management system concepts were studied, with a goal of reducing HPT blade cooling air supply temperature. An assessment will be made of the use of this air by the active clearance control system as well. Turbine component cooling designs incorporating advanced, high-effectiveness cooling features, will be evaluated. Turbine cooling flow control concepts will be studied at the cooling system level and the component level. Specific cooling features or sub-elements of an advanced HPT blade cooling design will be downselected for core fabrication and casting demonstrations.

Sterile Product Packaging and Delivery Systems.

PubMed

Akers, Michael J

2015-01-01

Both conventional and more advanced product container and delivery systems are the focus of this brief article. Six different product container systems will be discussed, plus advances in primary packaging for special delivery systems and needle technology.

Hybrid and Electric Advanced Vehicle Systems Simulation

NASA Technical Reports Server (NTRS)

Beach, R. F.; Hammond, R. A.; Mcgehee, R. K.

1985-01-01

Predefined components connected to represent wide variety of propulsion systems. Hybrid and Electric Advanced Vehicle System (HEAVY) computer program is flexible tool for evaluating performance and cost of electric and hybrid vehicle propulsion systems. Allows designer to quickly, conveniently, and economically predict performance of proposed drive train.

Advanced information processing system: Local system services

NASA Technical Reports Server (NTRS)

Burkhardt, Laura; Alger, Linda; Whittredge, Roy; Stasiowski, Peter

1989-01-01

The Advanced Information Processing System (AIPS) is a multi-computer architecture composed of hardware and software building blocks that can be configured to meet a broad range of application requirements. The hardware building blocks are fault-tolerant, general-purpose computers, fault-and damage-tolerant networks (both computer and input/output), and interfaces between the networks and the computers. The software building blocks are the major software functions: local system services, input/output, system services, inter-computer system services, and the system manager. The foundation of the local system services is an operating system with the functions required for a traditional real-time multi-tasking computer, such as task scheduling, inter-task communication, memory management, interrupt handling, and time maintenance. Resting on this foundation are the redundancy management functions necessary in a redundant computer and the status reporting functions required for an operator interface. The functional requirements, functional design and detailed specifications for all the local system services are documented.

Degradation of TBC Systems in Environments Relevant to Advanced Gas Turbines for IGCC Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gleeson, Brian

2014-09-30

Air plasma sprayed (APS) thermal barrier coatings (TBCs) are used to provide thermal insulation for the hottest components in gas turbines. Zirconia stabilized with 7wt% yttria (7YSZ) is the most common ceramic top coat used for turbine blades. The 7YSZ coating can be degraded from the buildup of fly-ash deposits created in the power-generation process. Fly ash from an integrated gasification combined cycle (IGCC) system can result from coal-based syngas. TBCs are also exposed to harsh gas environments containing CO 2, SO 2, and steam. Degradation from the combined effects of fly ash and harsh gas atmospheres has the potentialmore » to severely limit TBC lifetimes. The main objective of this study was to use lab-scale testing to systematically elucidate the interplay between prototypical deposit chemistries (i.e., ash and its constituents, K 2SO 4, and FeS) and environmental oxidants (i.e., O 2, H 2O and CO 2) on the degradation behavior of advanced TBC systems. Several mechanisms of early TBC failure were identified, as were the specific fly-ash constituents responsible for degradation. The reactivity of MCrAlY bondcoats used in TBC systems was also investigated. The specific roles of oxide and sulfate components were assessed, together with the complex interplay between gas composition, deposit chemistry and alloy reactivity. Bondcoat composition design strategies to mitigate corrosion were established, particularly with regard to controlling phase constitution and the amount of reactive elements the bondcoat contains in order to achieve optimal corrosion resistance.« less

Composite containment systems for jet engine fan blades

NASA Technical Reports Server (NTRS)

Smith, G. T.

1981-01-01

The use of composites in fan blade containment systems is investigated and the associated structural benefits of the composite system design are identified. Two basic types of containment structures were investigated. The short finned concept was evaluated using Kevlar/epoxy laminates for fins which were mounted in a 6061 T-6 aluminum ring. The long fin concept was evaluated with Kevlar/epoxy, 6Al4V titanium, and 2024 T-3 aluminum fins. The unfinned configurations consisted of the base-line steel sheet, a circumferentially oriented aluminum honeycomb, and a Kevlar cloth filled ring. Results obtained show that a substantial reduction in the fan blade containment system weight is possible. Minimization of damage within the engine arising from impact interaction between blade debris and the engine structure is also achieved.

Dynamic Seals for Advanced Hydraulic Systems

DTIC Science & Technology

1981-08-01

AFWAL-TR-81-.2066 t DYNAMIC SEALS FOR ADVANCED HYDRAULIC SYSTEMS cb- Robert S. Olsen I Vought Corporation P.O. Box 225907 Dallas, Texas 75265 August...Aeronautical Laboratories Air Force Systems Command 41 Wright-Patterson Air Force Base, Ohio 45433 82 Q L * a G ’ - -"o OW NOTICE When Government...and is approved for Publication. BRUC&- PBELL • •RICHARD D. FRANKLIN, MAJOR, USAF I Power Systems Branch -Chief, Power Systems Branch Aerospace Power

A next generation advanced traveler information precursor system (ATIS 2.0 precursor system) system requirements.

DOT National Transportation Integrated Search

2016-12-01

Advanced Traveler Information Systems (ATIS) have experienced significant growth since their initial inception in the 1990s. Technologies have continued to evolve at a rapid pace, enabling the integration of advanced solutions for traveler informatio...

Lightweight engine containment. [Kevlar shielding

NASA Technical Reports Server (NTRS)

Weaver, A. T.

1977-01-01

Kevlar fabric styles and weaves were studied, as well as methods of application for advanced gas turbine engines. The Kevlar material was subjected to high speed impacts by simple projectiles fired from a rifle, as well as more complex shapes such as fan blades released from gas turbine rotors in a spin pit. Just contained data was developed for a variety of weave and/or application techniques, and a comparative containment weight efficiency was established for Kevlar containment applications. The data generated during these tests is being incorporated into an analytical design system so that blade containment trade-off studies between Kevlar and metal case engine structures can be made. Laboratory tests and engine environment tests were performed to determine the survivability of Kevlar in a gas turbine environment.

FDA Approval Summary: Atezolizumab for the Treatment of Patients with Progressive Advanced Urothelial Carcinoma after Platinum‐Containing Chemotherapy

PubMed Central

Suzman, Daniel; Maher, V. Ellen; Zhang, Lijun; Tang, Shenghui; Ricks, Tiffany; Palmby, Todd; Fu, Wentao; Liu, Qi; Goldberg, Kirsten B.; Kim, Geoffrey; Pazdur, Richard

2017-01-01

Abstract Until recently in the United States, no products were approved for second‐line treatment of advanced urothelial carcinoma. On May 18, 2016, the U.S. Food and Drug Administration approved atezolizumab for the treatment of patients with locally advanced or metastatic urothelial carcinoma whose disease progressed during or following platinum‐containing chemotherapy or within 12 months of neoadjuvant or adjuvant treatment with platinum‐containing chemotherapy. Atezolizumab is a programmed death‐ligand 1 (PD‐L1) blocking antibody and represents the first approved product directed against PD‐L1. This accelerated approval was based on results of a single‐arm trial in 310 patients with locally advanced or metastatic urothelial carcinoma who had disease progression after prior platinum‐containing chemotherapy. Patients received atezolizumab 1,200 mg intravenously every 3 weeks until disease progression or unacceptable toxicity. Key efficacy measures were objective response rate (ORR), as assessed by Independent Review per RECIST 1.1, and duration of response (DoR). With a median follow‐up of 14.4 months, confirmed ORR was 14.8% (95% CI: 11.1, 19.3) in all treated patients. Median DoR was not reached and response durations ranged from 2.1+ to 13.8+ months. Of the 46 responders, 37 patients had an ongoing response for ≥ 6 months. The most common adverse reactions (≥20%) were fatigue, decreased appetite, nausea, urinary tract infection, pyrexia, and constipation. Infection and immune‐related adverse events also occurred, including pneumonitis, hepatitis, colitis, endocrine disorders, and rashes. Overall, the benefit‐risk assessment was favorable to support accelerated approval. The observed clinical benefits need to be verified in confirmatory trial(s). Implications for Practice. This accelerated approval of atezolizumab for second‐line use in advanced urothelial carcinoma provides patients with an effective, novel treatment option for

FDA Approval Summary: Atezolizumab for the Treatment of Patients with Progressive Advanced Urothelial Carcinoma after Platinum-Containing Chemotherapy.

PubMed

Ning, Yang-Min; Suzman, Daniel; Maher, V Ellen; Zhang, Lijun; Tang, Shenghui; Ricks, Tiffany; Palmby, Todd; Fu, Wentao; Liu, Qi; Goldberg, Kirsten B; Kim, Geoffrey; Pazdur, Richard

2017-06-01

Until recently in the United States, no products were approved for second-line treatment of advanced urothelial carcinoma. On May 18, 2016, the U.S. Food and Drug Administration approved atezolizumab for the treatment of patients with locally advanced or metastatic urothelial carcinoma whose disease progressed during or following platinum-containing chemotherapy or within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy. Atezolizumab is a programmed death-ligand 1 (PD-L1) blocking antibody and represents the first approved product directed against PD-L1. This accelerated approval was based on results of a single-arm trial in 310 patients with locally advanced or metastatic urothelial carcinoma who had disease progression after prior platinum-containing chemotherapy. Patients received atezolizumab 1,200 mg intravenously every 3 weeks until disease progression or unacceptable toxicity. Key efficacy measures were objective response rate (ORR), as assessed by Independent Review per RECIST 1.1, and duration of response (DoR). With a median follow-up of 14.4 months, confirmed ORR was 14.8% (95% CI: 11.1, 19.3) in all treated patients. Median DoR was not reached and response durations ranged from 2.1+ to 13.8+ months. Of the 46 responders, 37 patients had an ongoing response for ≥ 6 months. The most common adverse reactions (≥20%) were fatigue, decreased appetite, nausea, urinary tract infection, pyrexia, and constipation. Infection and immune-related adverse events also occurred, including pneumonitis, hepatitis, colitis, endocrine disorders, and rashes. Overall, the benefit-risk assessment was favorable to support accelerated approval. The observed clinical benefits need to be verified in confirmatory trial(s). This accelerated approval of atezolizumab for second-line use in advanced urothelial carcinoma provides patients with an effective, novel treatment option for the management of their disease. This represents the first

An Advanced Commanding and Telemetry System

NASA Astrophysics Data System (ADS)

Hill, Maxwell G. G.

The Loral Instrumentation System 500 configured as an Advanced Commanding and Telemetry System (ACTS) supports the acquisition of multiple telemetry downlink streams, and simultaneously supports multiple uplink command streams for today's satellite vehicles. By using industry and federal standards, the system is able to support, without relying on a host computer, a true distributed dataflow architecture that is complemented by state-of-the-art RISC-based workstations and file servers.

Advanced Transport Operating Systems Program

NASA Technical Reports Server (NTRS)

White, John J.

1990-01-01

NASA-Langley's Advanced Transport Operating Systems Program employs a heavily instrumented, B 737-100 as its Transport Systems Research Vehicle (TRSV). The TRSV has been used during the demonstration trials of the Time Reference Scanning Beam Microwave Landing System (TRSB MLS), the '4D flight-management' concept, ATC data links, and airborne windshear sensors. The credibility obtainable from successful flight test experiments is often a critical factor in the granting of substantial commitments for commercial implementation by the FAA and industry. In the case of the TRSB MLS, flight test demonstrations were decisive to its selection as the standard landing system by the ICAO.

Resource loading system and method for use in atmosphere-containment scenarios

DOEpatents

Dilday, Jr., Daniel R.; Reyes, Roberto; Weidmeyer, Stanley

2017-09-12

The invention provides a system for preventing fluid exchange between the interior and exterior of containment enclosures such as process-, hazard-, and research-enclosure systems generally, gloveboxes, containment systems, isolation systems, confinement systems, cleanrooms, negative air systems, and positive air system areas while simultaneously providing material transfer into and out of the enclosures. The invention also provides a method for transporting material into or out of a containment structure.

An Advanced Battery Management System for Lithium Ion Batteries

DTIC Science & Technology

2011-08-01

MINI-SYMPOSIUM AUGUST 9-11 DEARBORN, MICHIGAN AN ADVANCED BATTERY MANAGEMENT SYSTEM FOR LITHIUM ION BATTERIES Bruce Pilvelait, Ph.D...COVERED - 4. TITLE AND SUBTITLE An Advanced Battery Management System for Lithium Ion Batteries 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...Management System for Lithium Ion Batteries Page 2 of 7 Figure 1: BMS architecture for a 24 VDC lithium-ion Silent Watch battery pack

Advances in hydrogel delivery systems for tissue regeneration.

PubMed

Toh, Wei Seong; Loh, Xian Jun

2014-12-01

Hydrogels are natural or synthetic polymer networks that have high water-absorbing capacity and closely mimic native extracellular matrices. As hydrogel-based cell delivery systems are being increasingly employed in regenerative medicine, several advances have been made in the hydrogel chemistry and modification for enhanced control of cell fate and functions, and modulation of cell and tissue responses against oxidative stress and inflammation in the tissue environment. This review aims to provide the state-of-the-art overview of the recent advances in field, discusses new perspectives and challenges in the regeneration of specific tissues, and highlights some of the limitations of current systems for possible future advancements. Copyright © 2014 Elsevier B.V. All rights reserved.

Vehicle and cargo container inspection system for drugs

NASA Astrophysics Data System (ADS)

Verbinski, Victor V.; Orphan, Victor J.

1999-06-01

A vehicle and cargo container inspection system has been developed which uses gamma-ray radiography to produce digital images useful for detection of drugs and other contraband. The system is comprised of a 1 Ci Cs137 gamma-ray source collimated into a fan beam which is aligned with a linear array of NaI gamma-ray detectors located on the opposite side of the container. The NaI detectors are operated in the pulse-counting mode. A digital image of the vehicle or container is obtained by moving the aligned source and detector array relative to the object. Systems have been demonstrated in which the object is stationary (source and detector array move on parallel tracks) and in which the object moves past a stationary source and detector array. Scanning speeds of ˜30 cm/s with a pixel size (at the object) of ˜1 cm have been achieved. Faster scanning speeds of ˜2 m/s have been demonstrated on railcars with more modest spatial resolution (4 cm pixels). Digital radiographic images are generated from the detector count rates. These images, recorded on a PC-based data acquisition and display system, are shown from several applications: 1) inspection of trucks and containers at a border crossing, 2) inspection of railcars at a border crossing, 3) inspection of outbound cargo containers for stolen automobiles, and 4) inspection of trucks and cars for terrorist bombs.

Advanced Air Transportation Technologies Project, Final Document Collection

NASA Technical Reports Server (NTRS)

Mogford, Richard H.; Wold, Sheryl (Editor)

2008-01-01

This CD ROM contains a compilation of the final documents of the Advanced Air Transportation Technologies (AAIT) project, which was an eight-year (1996 to 2004), $400M project managed by the Airspace Systems Program office, which was part of the Aeronautics Research Mission Directorate at NASA Headquarters. AAIT focused on developing advanced automation tools and air traffic management concepts that would help improve the efficiency of the National Airspace System, while maintaining or enhancing safety. The documents contained in the CD are final reports on AAIT tasks that serve to document the project's accomplishments over its eight-year term. Documents include information on: Advanced Air Transportation Technologies, Autonomous Operations Planner, Collaborative Arrival Planner, Distributed Air/Ground Traffic Management Concept Elements 5, 6, & 11, Direct-To, Direct-To Technology Transfer, Expedite Departure Path, En Route Data Exchange, Final Approach Spacing Tool - (Active and Passive), Multi-Center Traffic Management Advisor, Multi Center Traffic Management Advisor Technology Transfer, Surface Movement Advisor, Surface Management System, Surface Management System Technology Transfer and Traffic Flow Management Research & Development.

40 CFR 281.37 - Financial responsibility for UST systems containing petroleum.

Code of Federal Regulations, 2011 CFR

2011-07-01

... systems containing petroleum. 281.37 Section 281.37 Protection of Environment ENVIRONMENTAL PROTECTION... for No-Less-Stringent § 281.37 Financial responsibility for UST systems containing petroleum. (a) In... UST systems containing petroleum, the state requirements for financial responsibility for petroleum...

The NASA Advanced Exploration Systems Nuclear Thermal Propulsion Project

NASA Technical Reports Server (NTRS)

Houts, Michael G.; Mitchell, Doyce P.; Kim, Tony; Emrich, William J.; Hickman, Robert R.; Gerrish, Harold P.; Doughty, Glen; Belvin, Anthony; Clement, Steven; Borowski, Stanley K.;

Remote-Reading Safety and Safeguards Surveillance System for 3013 Containers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lechelt, W. M.; Skorpik, J. R.; Silvers, K. L.

2002-02-26

At Hanford's Plutonium Finishing Plant (PFP), plutonium oxide is being loaded into stainless steel containers for long-term storage on the Hanford Site. These containers consist of two weld-sealed stainless steel cylinders nested one within the other. A third container holds the plutonium within the inner cylinder. This design meets the U.S. Department of Energy (DOE) storage standard, DOE-STD- 3013-2000, which anticipates a 50-year storage lifetime. The 3013 standard also requires a container surveillance program to continuously monitor pressure and to assure safeguards are adequate. However, the configuration of the container system makes using conventional measurement and monitoring methods difficult. Tomore » better meet the 3013 monitoring requirements, a team from Fluor Hanford (who manages the PFP), Pacific Northwest National Laboratory (PNNL), and Vista Engineering Technologies, LLC, developed a safer, cost-efficient, remote PFP 3013 container surveillance system. This new surveillance system is a combination of two successfully deployed technologies: (1) a magnetically coupled pressure gauge developed by Vista Engineering and (2) a radio frequency (RF) tagging device developed by PNNL. This system provides continuous, 100% monitoring of critical parameters with the containers in place, as well as inventory controls. The 3013 container surveillance system consists of three main elements: (1) an internal magnetic pressure sensor package, (2) an instrument pod (external electronics package), and (3) a data acquisition storage and display computer. The surveillance system described in this paper has many benefits for PFP and DOE in terms of cost savings and reduced personnel exposure. In addition, continuous safety monitoring (i.e., internal container pressure and temperature) of every container is responsible nuclear material stewardship and fully meets and exceeds DOE's Integrated Surveillance Program requirements.« less

Freight advanced traveler information system : functional requirements.

DOT National Transportation Integrated Search

2012-08-01

This report describes the System Requirement Specifications (SyRS) for a Freight Advanced Traveler Information System (FRATIS). The SyRS is based on user needs described in the FRATIS Concept of Operations (ConOps), which cover the essential function...

Development of advanced fuel cell system

NASA Technical Reports Server (NTRS)

Gitlow, B.; Meyer, A. P.; Bell, W. F.; Martin, R. E.

1978-01-01

An experimental program was conducted continuing the development effort to improve the weight, life, and performance characteristics of hydrogen-oxygen alkaline fuel cells for advanced power systems. These advanced technology cells operate with passive water removal which contributes to a lower system weight and extended operating life. Endurance evaluation of two single cells and two, two-cell plaques was continued. Three new test articles were fabricated and tested. A single cell completed 7038 hours of endurance testing. This cell incorporated a Fybex matrix, hybrid-frame, PPF anode, and a 90 Au/10 Pt cathode. This configuration was developed to extend cell life. Two cell plaques with dedicated flow fields and manifolds for all fluids did not exhibit the cell-to-cell electrolyte transfer that limited the operating life of earlier multicell plaques.

Physics of systems containing neutron stars

NASA Technical Reports Server (NTRS)

Ruderman, Malvin

1996-01-01

This grant dealt with several topics related to the dynamics of systems containing a compact object. Most of the research dealt with systems containing Neutron Stars (NS's), but a Black Hole (BH) or a White Dwarf (WD) in situations relevant to NS systems were also addressed. Among the systems were isolated regular pulsars, Millisecond Pulsars (MSP's) that are either Single (SMP's) or in a binary (BMP's), Low Mass X-Ray Binaries (LMXB's) and Cataclysmic Variables (CV's). Also dealt with was one aspect of NS structure, namely NS superfluidity. A large fraction of the research dealt with irradiation-driven winds from companions which turned out to be of importance in the evolution of LMXB's and MSP's, be they SMP's or BMP's. While their role during LMXB evolution (i.e. during the accretion phase) is not yet clear, they may play an important role in turning BMP's into SMP's and also in bringing about the formation of planets around MSP's. Work was concentrated on the following four problems: The Windy Pulsar B197+20 and its Evolution; Wind 'Echoes' in Tight Binaries; Post Nova X-ray Emission in CV's; and Dynamics of Pinned Superfluids in Neutron Stars.

Advanced Integrated Power and Attitude Control System (IPACS) study

NASA Technical Reports Server (NTRS)

Oglevie, R. E.; Eisenhaure, D. B.

1985-01-01

Integrated Power and Attitude Control System (IPACS) studies performed over a decade ago established the feasibility of simultaneously satisfying the demands of energy storage and attitude control through the use of rotating flywheels. It was demonstrated that, for a wide spectrum of applications, such a system possessed many advantages over contemporary energy storage and attitude control approaches. More recent technology advances in composite material rotors, magnetic suspension systems, and power control electronics have triggered new optimism regarding the applicability and merits of this concept. This study is undertaken to define an advanced IPACS and to evaluate its merits for a space station application. System and component designs are developed to establish the performance of this concept and system trade studies conducted to examine the viability of this approach relative to conventional candidate systems. It is clearly demonstrated that an advanced IPACS concept is not only feasible, but also offers substantial savings in mass and life-cycle cost for the space station mission.

Distributed sensor coordination for advanced energy systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tumer, Kagan

Motivation: The ability to collect key system level information is critical to the safe, efficient and reliable operation of advanced power systems. Recent advances in sensor technology have enabled some level of decision making directly at the sensor level. However, coordinating large numbers of sensors, particularly heterogeneous sensors, to achieve system level objectives such as predicting plant efficiency, reducing downtime or predicting outages requires sophisticated coordination algorithms. Indeed, a critical issue in such systems is how to ensure the interaction of a large number of heterogenous system components do not interfere with one another and lead to undesirable behavior. Objectivesmore » and Contributions: The long-term objective of this work is to provide sensor deployment, coordination and networking algorithms for large numbers of sensors to ensure the safe, reliable, and robust operation of advanced energy systems. Our two specific objectives are to: 1. Derive sensor performance metrics for heterogeneous sensor networks. 2. Demonstrate effectiveness, scalability and reconfigurability of heterogeneous sensor network in advanced power systems. The key technical contribution of this work is to push the coordination step to the design of the objective functions of the sensors, allowing networks of heterogeneous sensors to be controlled. By ensuring that the control and coordination is not specific to particular sensor hardware, this approach enables the design and operation of large heterogeneous sensor networks. In addition to the coordination coordination mechanism, this approach allows the system to be reconfigured in response to changing needs (e.g., sudden external events requiring new responses) or changing sensor network characteristics (e.g., sudden changes to plant condition). Impact: The impact of this work extends to a large class of problems relevant to the National Energy Technology Laboratory including sensor placement

Integrated System Test of the Advanced Instructional System (AIS). Final Report.

ERIC Educational Resources Information Center

Lintz, Larry M.; And Others

The integrated system test for the Advanced Instructional System (AIS) was designed to provide quantitative information regarding training time reductions resulting from certain computer managed instruction features. The reliabilities of these features and of support systems were also investigated. Basic computer managed instruction reduced…

Advanced energy system program

NASA Astrophysics Data System (ADS)

Trester, K.

1987-06-01

The ogjectives are to design, develop, and demonstrate a natural-gas-fueled, highly recuperated, 50 kw Brayton-cycle cogeneration system for commercial, institutional, and multifamily residential applications. Recent marketing studies have shown that the Advanced Energy System (AES), with its many cost-effective features, has the potential to offer significant reductions in annual electrical and thermal energy costs to the consumer. Specific advantates of the system that result in low cost ownership are high electrical efficiency (34 percent, LHV), low maintenance, high reliability and long life (20 years). Significant technical features include: an integral turbogenerator with shaft-speed permanent magnet generator; a rotating assembly supported by compliant foil air bearings; a formed-tubesheet plate/fin recuperator with 91 percent effectiveness; and a bi-directional power conditioner to ultilize the generator for system startup. The planned introduction of catalytic combustion will further enhance the economic and ecological attractiveness.

Evaluation of reliability modeling tools for advanced fault tolerant systems

NASA Technical Reports Server (NTRS)

Baker, Robert; Scheper, Charlotte

1986-01-01

The Computer Aided Reliability Estimation (CARE III) and Automated Reliability Interactice Estimation System (ARIES 82) reliability tools for application to advanced fault tolerance aerospace systems were evaluated. To determine reliability modeling requirements, the evaluation focused on the Draper Laboratories' Advanced Information Processing System (AIPS) architecture as an example architecture for fault tolerance aerospace systems. Advantages and limitations were identified for each reliability evaluation tool. The CARE III program was designed primarily for analyzing ultrareliable flight control systems. The ARIES 82 program's primary use was to support university research and teaching. Both CARE III and ARIES 82 were not suited for determining the reliability of complex nodal networks of the type used to interconnect processing sites in the AIPS architecture. It was concluded that ARIES was not suitable for modeling advanced fault tolerant systems. It was further concluded that subject to some limitations (the difficulty in modeling systems with unpowered spare modules, systems where equipment maintenance must be considered, systems where failure depends on the sequence in which faults occurred, and systems where multiple faults greater than a double near coincident faults must be considered), CARE III is best suited for evaluating the reliability of advanced tolerant systems for air transport.

Advanced Microelectronics Technologies for Future Small Satellite Systems

NASA Technical Reports Server (NTRS)

Alkalai, Leon

1999-01-01

Future small satellite systems for both Earth observation as well as deep-space exploration are greatly enabled by the technological advances in deep sub-micron microelectronics technologies. Whereas these technological advances are being fueled by the commercial (non-space) industries, more recently there has been an exciting new synergism evolving between the two otherwise disjointed markets. In other words, both the commercial and space industries are enabled by advances in low-power, highly integrated, miniaturized (low-volume), lightweight, and reliable real-time embedded systems. Recent announcements by commercial semiconductor manufacturers to introduce Silicon On Insulator (SOI) technology into their commercial product lines is driven by the need for high-performance low-power integrated devices. Moreover, SOI has been the technology of choice for many space semiconductor manufacturers where radiation requirements are critical. This technology has inherent radiation latch-up immunity built into the process, which makes it very attractive to space applications. In this paper, we describe the advanced microelectronics and avionics technologies under development by NASA's Deep Space Systems Technology Program (also known as X2000). These technologies are of significant benefit to both the commercial satellite as well as the deep-space and Earth orbiting science missions. Such a synergistic technology roadmap may truly enable quick turn-around, low-cost, and highly capable small satellite systems for both Earth observation as well as deep-space missions.

Advanced orbit transfer vehicle propulsion system study

NASA Technical Reports Server (NTRS)

Cathcart, J. A.; Cooper, T. W.; Corringrato, R. M.; Cronau, S. T.; Forgie, S. C.; Harder, M. J.; Mcallister, J. G.; Rudman, T. J.; Stoneback, V. W.

1985-01-01

A reuseable orbit transfer vehicle concept was defined and subsequent recommendations for the design criteria of an advanced LO2/LH2 engine were presented. The major characteristics of the vehicle preliminary design include a low lift to drag aerocapture capability, main propulsion system failure criteria of fail operational/fail safe, and either two main engines with an attitude control system for backup or three main engines to meet the failure criteria. A maintenance and servicing approach was also established for the advanced vehicle and engine concepts. Design tradeoff study conclusions were based on the consideration of reliability, performance, life cycle costs, and mission flexibility.

Advanced X-ray Spectroscopic Methods for Studying Iron-Sulfur-Containing Proteins and Model Complexes.

PubMed

DeBeer, Serena

2018-01-01

In this chapter, a brief overview of X-ray spectroscopic methods that may be utilized to obtain insight into the geometric and electronic structure of iron-sulfur proteins is provided. These methods include conventional methods, such as metal and ligand K-edge X-ray absorption, as well as more advanced methods including nonresonant and resonant X-ray emission. In each section, the basic information content of the spectra is highlighted and important experimental considerations are discussed. Throughout the chapter, recent applications to iron-sulfur-containing models and proteins are highlighted. © 2018 Elsevier Inc. All rights reserved.

Advanced public transportation system deployment in the United States

DOT National Transportation Integrated Search

1999-01-01

This report documents work performed under FTA's Advanced Public Transportation Systems (APTS) Program, a program structured to undertake research and development of innovative applications of advanced navigation, information, and communication techn...

An Advanced Platform for Biomolecular Detection and Analysis Systems

DTIC Science & Technology

2005-02-01

AFRL-IF-RS-TR-2005-54 Final Technical Report February 2005 AN ADVANCED PLATFORM FOR BIOMOLECULAR DETECTION AND ANALYSIS SYSTEMS...SUBTITLE AN ADVANCED PLATFORM FOR BIOMOLECULAR DETECTION AND ANALYSIS SYSTEMS 6. AUTHOR(S) David J. Beebe 5. FUNDING NUMBERS G...detection, analysis and response as well as many non BC warfare applications such as environmental toxicology, clinical detection and diagnosis

Apparatus for supporting a cryogenic fluid containment system within an enclosure

DOEpatents

Zhang, Burt X.; Ganni, Venkatarao; Stifle, Kirk E.

1995-01-01

An apparatus for supporting at least one inner cryogenic fluid containment system within an outer isolating enclosure to retard heat transfer into the inner containment system comprising a plurality of supports serially interconnected and laterally spaced by lateral connections to extend the heat conduction path into the inner containment system.

Advanced public transportation systems : the state of the art

DOT National Transportation Integrated Search

1991-03-01

This report documents one of the early initiatives of UMTA's Advanced Public Transportation Systems (APTS) Program, a program structured to undertake research and development of innovative applications of advanced navigation, information, and communi...

Performance of advance warning systems in a coordinated system : final report.

DOT National Transportation Integrated Search

2016-09-01

The Advance Warning System (AWS), developed by the Nebraska Department of Roads (NDOR) has proven to be effective at improving traffic safety at isolated signalized intersections. However, the effectiveness of the system has not been analyzed at sign...

Advanced information processing system: Input/output system services

NASA Technical Reports Server (NTRS)

Masotto, Tom; Alger, Linda

1989-01-01

The functional requirements and detailed specifications for the Input/Output (I/O) Systems Services of the Advanced Information Processing System (AIPS) are discussed. The introductory section is provided to outline the overall architecture and functional requirements of the AIPS system. Section 1.1 gives a brief overview of the AIPS architecture as well as a detailed description of the AIPS fault tolerant network architecture, while section 1.2 provides an introduction to the AIPS systems software. Sections 2 and 3 describe the functional requirements and design and detailed specifications of the I/O User Interface and Communications Management modules of the I/O System Services, respectively. Section 4 illustrates the use of the I/O System Services, while Section 5 concludes with a summary of results and suggestions for future work in this area.

Advanced Ground Systems Maintenance Cryogenics Test Lab Control System Upgrade Project

NASA Technical Reports Server (NTRS)

Harp, Janice Leshay

2014-01-01

This project will outfit the Simulated Propellant Loading System (SPLS) at KSC's Cryogenics Test Laboratory with a new programmable logic control system. The control system upgrade enables the Advanced Ground Systems Maintenace Element Integration Team and other users of the SPLS to conduct testing in a controls environment similar to that used at the launch pad.

Advanced Dairy Unit for Advanced Livestock Production Curriculum. Instructor's Guide. AGDEX 410/00.

ERIC Educational Resources Information Center

Coday, Stan; Stewart, Bob R.

This instructor's guide contains 18 lessons for teaching advanced dairying in accordance with the Missouri State Board of Education's Vocational Instructional Management System. To make the unit easier for teachers to use, the following materials are provided in the front of the unit: objectives and competencies for each lesson, a references and…

77 FR 62270 - Proposed Revision Treatment of Non-Safety Systems for Passive Advanced Light Water Reactors

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-12

... for Passive Advanced Light Water Reactors AGENCY: Nuclear Regulatory Commission. ACTION: Standard... Passive Advanced Light Water Reactors.'' The current SRP does not contain guidance on the proposed RTNSS for Passive Advance Light Water Reactors. DATES: Submit comments by November 13, 2012. Comments...

The Role of Intelligent Agents in Advanced Information Systems

NASA Technical Reports Server (NTRS)

Kerschberg, Larry

1999-01-01

In this presentation we review the current ongoing research within George Mason University's (GMU) Center for Information Systems Integration and Evolution (CISE). We define characteristics of advanced information systems, discuss a family of agents for such systems, and show how GMU's Domain modeling tools and techniques can be used to define a product line Architecture for configuring NASA missions. These concepts can be used to define Advanced Engineering Environments such as those envisioned for NASA's new initiative for intelligent design and synthesis environments.

Advanced integrated life support system update

NASA Technical Reports Server (NTRS)

Whitley, Phillip E.

1994-01-01

The Advanced Integrated Life Support System Program (AILSS) is an advanced development effort to integrate the life support and protection requirements using the U.S. Navy's fighter/attack mission as a starting point. The goal of AILSS is to optimally mate protection from altitude, acceleration, chemical/biological agent, thermal environment (hot, cold, and cold water immersion) stress as well as mission enhancement through improved restraint, night vision, and head-mounted reticules and displays to ensure mission capability. The primary emphasis to date has been to establish garment design requirements and tradeoffs for protection. Here the garment and the human interface are treated as a system. Twelve state-off-the-art concepts from government and industry were evaluated for design versus performance. On the basis of a combination of centrifuge, thermal manikin data, thermal modeling, and mobility studies, some key design parameters have been determined. Future efforts will concentrate on the integration of protection through garment design and the use of a single layer, multiple function concept to streamline the garment system.

Supervisory Control System Architecture for Advanced Small Modular Reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cetiner, Sacit M; Cole, Daniel L; Fugate, David L

2013-08-01

This technical report was generated as a product of the Supervisory Control for Multi-Modular SMR Plants project within the Instrumentation, Control and Human-Machine Interface technology area under the Advanced Small Modular Reactor (SMR) Research and Development Program of the U.S. Department of Energy. The report documents the definition of strategies, functional elements, and the structural architecture of a supervisory control system for multi-modular advanced SMR (AdvSMR) plants. This research activity advances the state-of-the art by incorporating decision making into the supervisory control system architectural layers through the introduction of a tiered-plant system approach. The report provides a brief history ofmore » hierarchical functional architectures and the current state-of-the-art, describes a reference AdvSMR to show the dependencies between systems, presents a hierarchical structure for supervisory control, indicates the importance of understanding trip setpoints, applies a new theoretic approach for comparing architectures, identifies cyber security controls that should be addressed early in system design, and describes ongoing work to develop system requirements and hardware/software configurations.« less

Expert system for controlling plant growth in a contained environment

NASA Technical Reports Server (NTRS)

May, George A. (Inventor); Lanoue, Mark Allen (Inventor); Bethel, Matthew (Inventor); Ryan, Robert E. (Inventor)

2011-01-01

In a system for optimizing crop growth, vegetation is cultivated in a contained environment, such as a greenhouse, an underground cavern or other enclosed space. Imaging equipment is positioned within or about the contained environment, to acquire spatially distributed crop growth information, and environmental sensors are provided to acquire data regarding multiple environmental conditions that can affect crop development. Illumination within the contained environment, and the addition of essential nutrients and chemicals are in turn controlled in response to data acquired by the imaging apparatus and environmental sensors, by an "expert system" which is trained to analyze and evaluate crop conditions. The expert system controls the spatial and temporal lighting pattern within the contained area, and the timing and allocation of nutrients and chemicals to achieve optimized crop development. A user can access the "expert system" remotely, to assess activity within the growth chamber, and can override the "expert system".

Expert system for controlling plant growth in a contained environment

NASA Technical Reports Server (NTRS)

May, George A. (Inventor); Lanoue, Mark Allen (Inventor); Bethel, Matthew (Inventor); Ryan, Robert E. (Inventor)

2009-01-01

In a system for optimizing crop growth, vegetation is cultivated in a contained environment, such as a greenhouse, an underground cavern or other enclosed space. Imaging equipment is positioned within or about the contained environment, to acquire spatially distributed crop growth information, and environmental sensors are provided to acquire data regarding multiple environmental conditions that can affect crop development. Illumination within the contained environment, and the addition of essential nutrients and chemicals are in turn controlled in response to data acquired by the imaging apparatus and environmental sensors, by an ''expert system'' which is trained to analyze and evaluate crop conditions. The expert system controls the spatial and temporal lighting pattern within the contained area, and the timing and allocation of nutrients and chemicals to achieve optimized crop development. A user can access the ''expert system'' remotely, to assess activity within the growth chamber, and can override the ''expert system''.

Apparatus for supporting a cryogenic fluid containment system within an enclosure

DOEpatents

Zhang, B.X.; Ganni, V.; Stifle, K.E.

1995-01-31

An apparatus is disclosed for supporting at least one inner cryogenic fluid containment system within an outer isolating enclosure to retard heat transfer into the inner containment system comprising a plurality of supports serially interconnected and laterally spaced by lateral connections to extend the heat conduction path into the inner containment system. 8 figs.

Advanced radiology information system.

PubMed

Kolovou, L; Vatousi, M; Lymperopoulos, D; Koukias, M

2005-01-01

The innovative features of an advanced Radiology Information System (RIS) are presented in this paper. The interoperability of RIS with the other Intra-hospital Information Systems that interacts with, dealing with the compatibility and open architecture issues, are accomplished by two novel mechanisms [1]. The first one is the particular message handling system that is applied for the exchange of information, according to the Health Level Seven (HL7) protocol's specifications and serves the transfer of medical and administrative data among the RIS applications and data store unit. The same mechanism allows the secure and HL7-compatible interactions with the Hospital Information System (HIS) too. The second one implements the translation of information between the formats that HL7 and Digital Imaging and Communication in Medicine (DICOM) protocols specify, providing the communication between RIS and Picture and Archive Communication System (PACS). The whole structure ensures the automation of the every-day procedures that the ;medical protocol' specifies and provides its services through a friendly and easy to manage graphical user interface.

Advanced instrumentation for next-generation aerospace propulsion control systems

NASA Technical Reports Server (NTRS)

Barkhoudarian, S.; Cross, G. S.; Lorenzo, Carl F.

1993-01-01

New control concepts for the next generation of advanced air-breathing and rocket engines and hypersonic combined-cycle propulsion systems are analyzed. The analysis provides a database on the instrumentation technologies for advanced control systems and cross matches the available technologies for each type of engine to the control needs and applications of the other two types of engines. Measurement technologies that are considered to be ready for implementation include optical surface temperature sensors, an isotope wear detector, a brushless torquemeter, a fiberoptic deflectometer, an optical absorption leak detector, the nonintrusive speed sensor, and an ultrasonic triducer. It is concluded that all 30 advanced instrumentation technologies considered can be recommended for further development to meet need of the next generation of jet-, rocket-, and hypersonic-engine control systems.

Oxaliplatin-containing Preoperative Therapy in Locally Advanced Rectal Cancer: Local Response, Toxicity and Long-term Outcome.

PubMed

Dueland, S; Ree, A H; Grøholt, K K; Saelen, M G; Folkvord, S; Hole, K H; Seierstad, T; Larsen, S G; Giercksky, K E; Wiig, J N; Boye, K; Flatmark, K

2016-08-01

This non-randomised study was undertaken to examine oxaliplatin as possibly an intensifying component of sequential neoadjuvant therapy in locally advanced rectal cancer for improved local and metastatic outcome. Ninety-seven patients (57 T2-3 cases, 40 T4 cases) received two cycles of the Nordic FLOX regimen (oxaliplatin 85 mg/m(2) day 1 and bolus 5-fluorouracil 500 mg/m(2) and folinic acid 100 mg days 1 and 2) before long-course chemoradiotherapy with concomitant oxaliplatin and capecitabine, followed by pelvic surgery. Treatment toxicity, local tumour response and long-term outcome were recorded. Good histologic tumour regression was obtained in 72% of patients. Implementing protocol-specific dose adjustments, tolerance was acceptable and 95% of patients received the total prescribed radiation dose. Estimated 5 year progression-free and overall survival were 61% and 83%, respectively. T4 stage was associated with an inferior local response rate, which again was highly associated with impaired long-term outcome. In this cohort of rectal cancer patients dominated by T4 and advanced T3 cases given sequential oxaliplatin-containing preoperative therapy with acceptable toxicity, high tumour response rates and overall survival were obtained, consistent with both local and systemic effects. However, tumour response and long-term outcome remained inferior for a significant number of T4 cases, suggesting that the T4 entity is biologically heterogeneous with subgroups of patients eligible for further individualisation of therapy. Copyright © 2016 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

Advanced secondary power system for transport aircraft

NASA Technical Reports Server (NTRS)

Hoffman, A. C.; Hansen, I. G.; Beach, R. F.; Plencner, R. M.; Dengler, R. P.; Jefferies, K. S.; Frye, R. J.

1985-01-01

A concept for an advanced aircraft power system was identified that uses 20-kHz, 440-V, sin-wave power distribution. This system was integrated with an electrically powered flight control system and with other aircraft systems requiring secondary power. The resulting all-electric secondary power configuration reduced the empty weight of a modern 200-passenger, twin-engine transport by 10 percent and the mission fuel by 9 percent.

Advanced Manufacturing Systems in Food Processing and Packaging Industry

NASA Astrophysics Data System (ADS)

Shafie Sani, Mohd; Aziz, Faieza Abdul

2013-06-01

In this paper, several advanced manufacturing systems in food processing and packaging industry are reviewed, including: biodegradable smart packaging and Nano composites, advanced automation control system consists of fieldbus technology, distributed control system and food safety inspection features. The main purpose of current technology in food processing and packaging industry is discussed due to major concern on efficiency of the plant process, productivity, quality, as well as safety. These application were chosen because they are robust, flexible, reconfigurable, preserve the quality of the food, and efficient.

Evolution of an arsenal: structural and functional diversification of the venom system in the advanced snakes (Caenophidia).

PubMed

Fry, Bryan G; Scheib, Holger; van der Weerd, Louise; Young, Bruce; McNaughtan, Judith; Ramjan, S F Ryan; Vidal, Nicolas; Poelmann, Robert E; Norman, Janette A

2008-02-01

Venom is a key innovation underlying the evolution of advanced snakes (Caenophidia). Despite this, very little is known about venom system structural diversification, toxin recruitment event timings, or toxin molecular evolution. A multidisciplinary approach was used to examine the diversification of the venom system and associated toxins across the full range of the approximately 100 million-year-old advanced snake clade with a particular emphasis upon families that have not secondarily evolved a front-fanged venom system ( approximately 80% of the 2500 species). Analysis of cDNA libraries revealed complex venom transcriptomes containing multiple toxin types including three finger toxins, cobra venom factor, cysteine-rich secretory protein, hyaluronidase, kallikrein, kunitz, lectin, matrix metalloprotease, phospholipase A(2), snake venom metalloprotease/a disintegrin and metalloprotease, and waprin. High levels of sequence diversity were observed, including mutations in structural and functional residues, changes in cysteine spacing, and major deletions/truncations. Morphological analysis comprising gross dissection, histology, and magnetic resonance imaging also demonstrated extensive modification of the venom system architecture in non-front-fanged snakes in contrast to the conserved structure of the venom system within the independently evolved front-fanged elapid or viperid snakes. Further, a reduction in the size and complexity of the venom system was observed in species in which constriction has been secondarily evolved as the preferred method of prey capture or dietary preference has switched from live prey to eggs or to slugs/snails. Investigation of the timing of toxin recruitment events across the entire advanced snake radiation indicates that the evolution of advanced venom systems in three front-fanged lineages is associated with recruitment of new toxin types or explosive diversification of existing toxin types. These results support the role of venom

Covalent Polymers Containing Discrete Heterocyclic Anion Receptors

PubMed Central

Rambo, Brett M.; Silver, Eric S.; Bielawski, Christopher W.; Sessler, Jonathan L.

2010-01-01

This chapter covers recent advances in the development of polymeric materials containing discrete heterocyclic anion receptors, and focuses on advances in anion binding and chemosensor chemistry. The development of polymers specific for anionic species is a relatively new and flourishing area of materials chemistry. The incorporation of heterocyclic receptors capable of complexing anions through non-covalent interactions (e.g., hydrogen bonding and electrostatic interactions) provides a route to not only sensitive but also selective polymer materials. Furthermore, these systems have been utilized in the development of polymers capable of extracting anionic species from aqueous environments. These latter materials may lead to advances in water purification and treatment of diseases resulting from surplus ions. PMID:20871791

Magnetic suspension and balance system advanced study, 1989 design

NASA Technical Reports Server (NTRS)

Boom, Roger W.; Eyssa, Y. M.; Abdelsalam, Moustafa K.; Mcintosh, Glen E.

1991-01-01

The objectives are to experimentally confirm several advanced design concepts on the Magnetic Suspension and Balance Systems (MSBS). The advanced design concepts were identified as potential improvements by Madison Magnetics, Inc. (MMI) during 1984 and 1985 studies of an MSBS utilizing 14 external superconductive coils and a superconductive solenoid in an airplane test model suspended in a wind tunnel. This study confirmed several advanced design concepts on magnetic suspension and balance systems. The 1989 MSBS redesign is based on the results of these experiments. Savings of up to 30 percent in supporting magnet ampere meters and 50 percent in energy stored over the 1985 design were achieved.

Investigation of an advanced fault tolerant integrated avionics system

NASA Technical Reports Server (NTRS)

Dunn, W. R.; Cottrell, D.; Flanders, J.; Javornik, A.; Rusovick, M.

1986-01-01

Presented is an advanced, fault-tolerant multiprocessor avionics architecture as could be employed in an advanced rotorcraft such as LHX. The processor structure is designed to interface with existing digital avionics systems and concepts including the Army Digital Avionics System (ADAS) cockpit/display system, navaid and communications suites, integrated sensing suite, and the Advanced Digital Optical Control System (ADOCS). The report defines mission, maintenance and safety-of-flight reliability goals as might be expected for an operational LHX aircraft. Based on use of a modular, compact (16-bit) microprocessor card family, results of a preliminary study examining simplex, dual and standby-sparing architectures is presented. Given the stated constraints, it is shown that the dual architecture is best suited to meet reliability goals with minimum hardware and software overhead. The report presents hardware and software design considerations for realizing the architecture including redundancy management requirements and techniques as well as verification and validation needs and methods.

Advanced flight control system study

NASA Technical Reports Server (NTRS)

Hartmann, G. L.; Wall, J. E., Jr.; Rang, E. R.; Lee, H. P.; Schulte, R. W.; Ng, W. K.

1982-01-01

A fly by wire flight control system architecture designed for high reliability includes spare sensor and computer elements to permit safe dispatch with failed elements, thereby reducing unscheduled maintenance. A methodology capable of demonstrating that the architecture does achieve the predicted performance characteristics consists of a hierarchy of activities ranging from analytical calculations of system reliability and formal methods of software verification to iron bird testing followed by flight evaluation. Interfacing this architecture to the Lockheed S-3A aircraft for flight test is discussed. This testbed vehicle can be expanded to support flight experiments in advanced aerodynamics, electromechanical actuators, secondary power systems, flight management, new displays, and air traffic control concepts.

[Development of performance evaluation and management system on advanced schistosomiasis medical treatment].

PubMed

Zhou, Xiao-Rong; Huang, Shui-Sheng; Gong, Xin-Guo; Cen, Li-Ping; Zhang, Cong; Zhu, Hong; Yang, Jun-Jing; Chen, Li

2012-04-01

To construct a performance evaluation and management system on advanced schistosomiasis medical treatment, and analyze and evaluate the work of the advanced schistosomiasis medical treatment over the years. By applying the database management technique and C++ programming technique, we inputted the information of the advanced schistosomiasis cases into the system, and comprehensively evaluated the work of the advanced schistosomiasis medical treatment through the cost-effect analysis, cost-effectiveness analysis, and cost-benefit analysis. We made a set of software formula about cost-effect analysis, cost-effectiveness analysis, and cost-benefit analysis. This system had many features such as clear building, easy to operate, friendly surface, convenient information input and information search. It could benefit the performance evaluation of the province's advanced schistosomiasis medical treatment work. This system can satisfy the current needs of advanced schistosomiasis medical treatment work and can be easy to be widely used.

Modeling of Spacecraft Advanced Chemical Propulsion Systems

NASA Technical Reports Server (NTRS)

Benfield, Michael P. J.; Belcher, Jeremy A.

2004-01-01

This paper outlines the development of the Advanced Chemical Propulsion System (ACPS) model for Earth and Space Storable propellants. This model was developed by the System Technology Operation of SAIC-Huntsville for the NASA MSFC In-Space Propulsion Project Office. Each subsystem of the model is described. Selected model results will also be shown to demonstrate the model's ability to evaluate technology changes in chemical propulsion systems.

Health requirements for advanced coal extraction systems

NASA Technical Reports Server (NTRS)

Zimmerman, W. F.

1980-01-01

Health requirements were developed as long range goals for future advanced coal extraction systems which would be introduced into the market in the year 2000. The goal of the requirements is that underground coal miners work in an environment that is as close as possible to the working conditions of the general population, that they do not exceed mortality and morbidity rates resulting from lung diseases that are comparable to those of the general population, and that their working conditions comply as closely as possible to those of other industries as specified by OSHA regulations. A brief technique for evaluating whether proposed advanced systems meet these safety requirements is presented, as well as a discussion of the costs of respiratory disability compensation.

System and method for liquid silicon containment

DOEpatents

Cliber, James A; Clark, Roger F; Stoddard, Nathan G; Von Dollen, Paul

2013-05-28

This invention relates to a system and a method for liquid silicon containment, such as during the casting of high purity silicon used in solar cells or solar modules. The containment apparatus includes a shielding member adapted to prevent breaching molten silicon from contacting structural elements or cooling elements of a casting device, and a volume adapted to hold a quantity of breaching molten silicon with the volume formed by a bottom and one or more sides.

System and method for liquid silicon containment

DOEpatents

Cliber, James A; Clark, Roger F; Stoddard, Nathan G; Von Dollen, Paul

2014-06-03

This invention relates to a system and a method for liquid silicon containment, such as during the casting of high purity silicon used in solar cells or solar modules. The containment apparatus includes a shielding ember adapted to prevent breaching molten silicon from contacting structural elements or cooling elements of a casting device, and a volume adapted to hold a quantity of breaching molten silicon with the volume formed by a bottom and one or more sides.

Advanced teleprocessing systems

NASA Astrophysics Data System (ADS)

Kleinrock, L.; Gerla, M.

1983-03-01

This Semi-Annual Technical Report covers research covering the period from October 1, 1982 to March 31, 1983. This contract has three primary designated research areas: packet radio systems, resource sharing and allocation, and distributed processing and control. This report contains abstracts of publications which summarize research results in these areas followed by the main body of the report which is devoted to a treatment of single- and multi-hop packet radio systems. In particular, the main body consists of a Ph.D. dissertation, Analysis of Throughput and Delay for Single- and Multi-Hop Packet Radio Networks. The work presents a new approach to evaluating the performance of multi-hop packet radio networks, namely, a study of the times between successful transmissions. Also studied is the behavior of packets in a multi-hop system when a fixed transmission radius is specified and this radius is then optimized for throughput. A Markov chain model is also introduced and solved numerically to evaluate transmission and flow control strategies in these systems.

System design impacts on optimization of the advanced radioisotope power system (ARPS) AMTEC cell

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hendricks, T.J.; Huang, C.

1998-07-01

Several NASA deep space missions require Advanced Radioisotope Power Systems (ARPS) to supply spacecraft power for various internal functions and mission instruments and experiments. AMTEC (Alkali-Metal Thermal-Electric Conversion) power conversion is the DOE-selected technology for an advanced, next- generation RPS to power these spacecraft. Advanced Modular Power Systems, Inc. (AMPS) has begun investigating the design of an AMTEC-based ARPS using the General Purpose Heat Source (GPHS) and the latest PX-5 AMTEC cell technology with refractory materials in critical components. This paper presents and discusses the system design methodology, and results of important system design tradeoffs and system design impacts onmore » the ARPS AMTEC cell design. This work investigated dual 2-GPHS system configurations and 4-GPHS system configurations with 16 side-mounted AMTEC cells operating at beginning-of-mission (BOM) and end-of-mission (EOM) GPHS heat dissipation conditions. Current design studies indicate using a refractory material AMTEC cell with 8-BASE tubes, 5.0 inches long, and 1.75 inches diameter in the 4-GPHS system configuration is the strongest design candidate to satisfy system performance requirements.« less

Software modifications to the Demonstration Advanced Avionics Systems (DAAS)

NASA Technical Reports Server (NTRS)

Nedell, B. F.; Hardy, G. H.

1984-01-01

Critical information required for the design of integrated avionics suitable for generation aviation is applied towards software modifications for the Demonstration Advanced Avionics System (DAAS). The program emphasizes the use of data busing, distributed microprocessors, shared electronic displays and data entry devices, and improved functional capability. A demonstration advanced avionics system (DAAS) is designed, built, and flight tested in a Cessna 402, twin engine, general aviation aircraft. Software modifications are made to DAAS at Ames concurrent with the flight test program. The changes are the result of the experience obtained with the system at Ames, and the comments of the pilots who evaluated the system.

Architectural development of an advanced EVA Electronic System

NASA Technical Reports Server (NTRS)

Lavelle, Joseph

1992-01-01

An advanced electronic system for future EVA missions (including zero gravity, the lunar surface, and the surface of Mars) is under research and development within the Advanced Life Support Division at NASA Ames Research Center. As a first step in the development, an optimum system architecture has been derived from an analysis of the projected requirements for these missions. The open, modular architecture centers around a distributed multiprocessing concept where the major subsystems independently process their own I/O functions and communicate over a common bus. Supervision and coordination of the subsystems is handled by an embedded real-time operating system kernel employing multitasking software techniques. A discussion of how the architecture most efficiently meets the electronic system functional requirements, maximizes flexibility for future development and mission applications, and enhances the reliability and serviceability of the system in these remote, hostile environments is included.

Populating the Advanced National Seismic System Comprehensive Earthquake Catalog

NASA Astrophysics Data System (ADS)

Earle, P. S.; Perry, M. R.; Andrews, J. R.; Withers, M. M.; Hellweg, M.; Kim, W. Y.; Shiro, B.; West, M. E.; Storchak, D. A.; Pankow, K. L.; Huerfano Moreno, V. A.; Gee, L. S.; Wolfe, C. J.

2016-12-01

The U.S. Geological Survey maintains a repository of earthquake information produced by networks in the Advanced National Seismic System with additional data from the ISC-GEM catalog and many non-U.S. networks through their contributions to the National Earthquake Information Center PDE bulletin. This Comprehensive Catalog (ComCat) provides a unified earthquake product while preserving attribution and contributor information. ComCat contains hypocenter and magnitude information with supporting phase arrival-time and amplitude measurements (when available). Higher-level products such as focal mechanisms, earthquake slip models, "Did You Feel It?" reports, ShakeMaps, PAGER impact estimates, earthquake summary posters, and tectonic summaries are also included. ComCat is updated as new events are processed and the catalog can be accesed at http://earthquake.usgs.gov/earthquakes/search/. Throughout the past few years, a concentrated effort has been underway to expand ComCat by integrating global and regional historic catalogs. The number of earthquakes in ComCat has more than doubled in the past year and it presently contains over 1.6 million earthquake hypocenters. We will provide an overview of catalog contents and a detailed description of numerous tools and semi-automated quality-control procedures developed to uncover errors including systematic magnitude biases, missing time periods, duplicate postings for the same events, and incorrectly associated events.

Accurate spin-orbit and spin-other-orbit contributions to the g-tensor for transition metal containing systems.

PubMed

Van Yperen-De Deyne, A; Pauwels, E; Van Speybroeck, V; Waroquier, M

2012-08-14

In this paper an overview is presented of several approximations within Density Functional Theory (DFT) to calculate g-tensors in transition metal containing systems and a new accurate description of the spin-other-orbit contribution for high spin systems is suggested. Various implementations in a broad variety of software packages (ORCA, ADF, Gaussian, CP2K, GIPAW and BAND) are critically assessed on various aspects including (i) non-relativistic versus relativistic Hamiltonians, (ii) spin-orbit coupling contributions and (iii) the gauge. Particular attention is given to the level of accuracy that can be achieved for codes that allow g-tensor calculations under periodic boundary conditions, as these are ideally suited to efficiently describe extended condensed-phase systems containing transition metals. In periodic codes like CP2K and GIPAW, the g-tensor calculation schemes currently suffer from an incorrect treatment of the exchange spin-orbit interaction and a deficient description of the spin-other-orbit term. In this paper a protocol is proposed, making the predictions of the exchange part to the g-tensor shift more plausible. Focus is also put on the influence of the spin-other-orbit interaction which becomes of higher importance for high-spin systems. In a revisited derivation of the various terms arising from the two-electron spin-orbit and spin-other-orbit interaction (SOO), new insight has been obtained revealing amongst other issues new terms for the SOO contribution. The periodic CP2K code has been adapted in view of this new development. One of the objectives of this study is indeed a serious enhancement of the performance of periodic codes in predicting g-tensors in transition metal containing systems at the same level of accuracy as the most advanced but time consuming spin-orbit mean-field approach. The methods are first applied on rhodium carbide but afterwards extended to a broad test set of molecules containing transition metals from the fourth

Passive cooling system for nuclear reactor containment structure

DOEpatents

Gou, Perng-Fei; Wade, Gentry E.

1989-01-01

A passive cooling system for the contaminant structure of a nuclear reactor plant providing protection against overpressure within the containment attributable to inadvertent leakage or rupture of the system components. The cooling system utilizes natural convection for transferring heat imbalances and enables the discharge of irradiation free thermal energy to the atmosphere for heat disposal from the system.

Evaluation of Container Closure System Integrity for Frozen Storage Drug Products.

PubMed

Nieto, Alejandra; Roehl, Holger; Brown, Helen; Nikoloff, Jonas; Adler, Michael; Mahler, Hanns-Christian

2016-01-01

Sometimes, drug product for parenteral administration is stored in a frozen state (e.g., -20 °C or -80 °C), particularly during early stages of development of some biotech molecules in order to provide sufficient stability. Shipment of frozen product could potentially be performed in the frozen state, yet possibly at different temperatures, for example, using dry ice (-80 °C). Container closure systems of drug products usually consist of a glass vial, rubber stopper, and an aluminum crimped cap. In the frozen state, the glass transition temperature (Tg) of commonly used rubber stoppers is between -55 and -65 °C. Below their Tg, rubber stoppers are known to lose their elastic properties and become brittle, and thus potentially fail to maintain container closure integrity in the frozen state. Leaks during frozen temperature storage and transportation are likely to be transient, yet, can possibly risk container closure integrity and lead to microbial contamination. After thawing, the rubber stopper is supposed to re-seal the container closure system. Given the transient nature of the possible impact on container closure integrity in the frozen state, typical container closure integrity testing methods (used at room temperature conditions) are unable to evaluate and thus confirm container closure integrity in the frozen state. Here we present the development of a novel method (thermal physical container closure integrity) for direct assessment of container closure integrity by a physical method (physical container closure integrity) at frozen conditions, using a modified He leakage test. In this study, different container closure systems were evaluated with regard to physical container closure integrity in the frozen state to assess the suitability of vial/stopper combinations and were compared to a gas headspace method. In summary, the thermal physical container closure integrity He leakage method was more sensitive in detecting physical container closure

Conceptual design study: Forest Fire Advanced System Technology (FFAST)

NASA Technical Reports Server (NTRS)

Nichols, J. D.; Warren, J. R.

1986-01-01

An integrated forest fire detection and mapping system that will be based upon technology available in the 1990s was defined. Uncertainties in emerging and advanced technologies related to the conceptual design were identified and recommended for inclusion as preferred system components. System component technologies identified for an end-to-end system include thermal infrared, linear array detectors, automatic georeferencing and signal processing, geosynchronous satellite communication links, and advanced data integration and display. Potential system configuration options were developed and examined for possible inclusion in the preferred system configuration. The preferred system configuration will provide increased performance and be cost effective over the system currently in use. Forest fire management user requirements and the system component emerging technologies were the basis for the system configuration design. A preferred system configuration was defined that warrants continued refinement and development, examined economic aspects of the current and preferred system, and provided preliminary cost estimates for follow-on system prototype development.

Advanced Land Imager Assessment System

NASA Technical Reports Server (NTRS)

Chander, Gyanesh; Choate, Mike; Christopherson, Jon; Hollaren, Doug; Morfitt, Ron; Nelson, Jim; Nelson, Shar; Storey, James; Helder, Dennis; Ruggles, Tim;

Advanced Fuel Cell System Thermal Management for NASA Exploration Missions

NASA Technical Reports Server (NTRS)

Burke, Kenneth A.

2009-01-01

The NASA Glenn Research Center is developing advanced passive thermal management technology to reduce the mass and improve the reliability of space fuel cell systems for the NASA exploration program. An analysis of a state-of-the-art fuel cell cooling systems was done to benchmark the portion of a fuel cell system s mass that is dedicated to thermal management. Additional analysis was done to determine the key performance targets of the advanced passive thermal management technology that would substantially reduce fuel cell system mass.

Gas chromatography: Possible application of advanced instrumentation developed for solar system exploration to space station cabin atmospheres

NASA Technical Reports Server (NTRS)

Carle, G. C.

1985-01-01

Gas chromatography (GC) technology was developed for flight experiments in solar system exploration. The GC is a powerful analytical technique with simple devices separating individual components from complex mixtures to make very sensitive quantitative and qualitative measurements. It monitors samples containing mixtures of fixed gases and volatile organic molecules. The GC was used on the Viking mission in support of life detection experiments and on the Pioneer Venus Large Probe to determine the composition of the venusian atmosphere. A flight GC is under development to study the progress and extent of STS astronaut denitrogenation prior to extravehicular activity. Advanced flight GC concepts and systems for future solar system exploration are also studied. Studies include miniature ionization detectors and associated control systems capable of detecting from ppb up to 100% concentration levels. Further miniaturization is investigated using photolithography and controlled chemical etching in silicon wafers. Novel concepts such as ion mobility drift spectroscopy and multiplex gas chromatography are also developed for future flight experiments. These powerful analytical concepts and associated hardware are ideal for the monitoring of cabin atmospheres containing potentially dangerous volatile compounds.

Advanced electrophysiologic mapping systems: an evidence-based analysis.

PubMed

2006-01-01

To assess the effectiveness, cost-effectiveness, and demand in Ontario for catheter ablation of complex arrhythmias guided by advanced nonfluoroscopy mapping systems. Particular attention was paid to ablation for atrial fibrillation (AF). Tachycardia Tachycardia refers to a diverse group of arrhythmias characterized by heart rates that are greater than 100 beats per minute. It results from abnormal firing of electrical impulses from heart tissues or abnormal electrical pathways in the heart because of scars. Tachycardia may be asymptomatic, or it may adversely affect quality of life owing to symptoms such as palpitations, headaches, shortness of breath, weakness, dizziness, and syncope. Atrial fibrillation, the most common sustained arrhythmia, affects about 99,000 people in Ontario. It is associated with higher morbidity and mortality because of increased risk of stroke, embolism, and congestive heart failure. In atrial fibrillation, most of the abnormal arrhythmogenic foci are located inside the pulmonary veins, although the atrium may also be responsible for triggering or perpetuating atrial fibrillation. Ventricular tachycardia, often found in patients with ischemic heart disease and a history of myocardial infarction, is often life-threatening; it accounts for about 50% of sudden deaths. Treatment of Tachycardia The first line of treatment for tachycardia is antiarrhythmic drugs; for atrial fibrillation, anticoagulation drugs are also used to prevent stroke. For patients refractory to or unable to tolerate antiarrhythmic drugs, ablation of the arrhythmogenic heart tissues is the only option. Surgical ablation such as the Cox-Maze procedure is more invasive. Catheter ablation, involving the delivery of energy (most commonly radiofrequency) via a percutaneous catheter system guided by X-ray fluoroscopy, has been used in place of surgical ablation for many patients. However, this conventional approach in catheter ablation has not been found to be effective for

Advanced EVA system design requirements study, executive summary

NASA Technical Reports Server (NTRS)

1986-01-01

Design requirements and criteria for the space station advanced Extravehicular Activity System (EVAS) including crew enclosures, portable life support systems, maneuvering propulsion systems, and related EVA support equipment were established. The EVA mission requirements, environments, and medical and physiological requirements, as well as operational, procedures and training issues were considered.

Exact sum rules for inhomogeneous systems containing a zero mode

DOE Office of Scientific and Technical Information (OSTI.GOV)

Amore, Paolo, E-mail: paolo.amore@gmail.com

2014-10-15

We show that the formulas for the sum rules for the eigenvalues of inhomogeneous systems that we have obtained in two recent papers are incomplete when the system contains a zero mode. We prove that there are finite contributions of the zero mode to the sum rules and we explicitly calculate the expressions for the sum rules of order one and two. The previous results for systems that do not contain a zero mode are unaffected. - Highlights: • We discuss the sum rules of the eigenvalues of inhomogeneous systems containing a zero mode. • We derive the explicit expressionsmore » for sum rules of order one and two. • We perform accurate numerical tests of these results for three examples.« less

Phase Equilibria of the Brine Systems Containing Strontium and Calcium Ions

NASA Astrophysics Data System (ADS)

Wang, Xia; Zhao, Kaiyu; Li, Long; Guo, Yafei; Meng, Lingzong; Deng, Tianlong

2017-12-01

It is well known that the comprehensive utilization of the Salt Lake resources successfully must be guided corresponding to the aqueous phase equilibria and phase diagrams. Researches on the phase relationships of brine systems containing calcium and strontium ions are essential to promote the development for the relative resources discovered in China at recent years. In this paper, the phase equilibria of calcium-containing systems, strontium-containing systems and calcium-strontium coexisted brine systems around the world were reviewed. The problems existed recently and new trends in future were point out.

Advancing the practice of systems engineering at JPL

NASA Technical Reports Server (NTRS)

Jansma, Patti A.; Jones, Ross M.

2006-01-01

In FY 2004, JPL launched an initiative to improve the way it practices systems engineering. The Lab's senior management formed the Systems Engineering Advancement (SEA) Project in order to "significantly advance the practice and organizational capabilities of systems engineering at JPL on flight projects and ground support tasks." The scope of the SEA Project includes the systems engineering work performed in all three dimensions of a program, project, or task: 1. the full life-cycle, i.e., concept through end of operations 2. the full depth, i.e., Program, Project, System, Subsystem, Element (SE Levels 1 to 5) 3. the full technical scope, e.g., the flight, ground and launch systems, avionics, power, propulsion, telecommunications, thermal, etc. The initial focus of their efforts defined the following basic systems engineering functions at JPL: systems architecture, requirements management, interface definition, technical resource management, system design and analysis, system verification and validation, risk management, technical peer reviews, design process management and systems engineering task management, They also developed a list of highly valued personal behaviors of systems engineers, and are working to inculcate those behaviors into members of their systems engineering community. The SEA Project is developing products, services, and training to support managers and practitioners throughout the entire system lifecycle. As these are developed, each one needs to be systematically deployed. Hence, the SEA Project developed a deployment process that includes four aspects: infrastructure and operations, communication and outreach, education and training, and consulting support. In addition, the SEA Project has taken a proactive approach to organizational change management and customer relationship management - both concepts and approaches not usually invoked in an engineering environment. This paper'3 describes JPL's approach to advancing the practice of

Benefits assessment of advanced public transportation system technologies, update 2000

DOT National Transportation Integrated Search

This report was performed under the Federal Transit Administration's (FTA) Advanced Public Transportation Systems (APTS) Program. This program focuses on the development and demonstration of innovative advanced navigation, information and communicati...

Advanced-technology space station study: Summary of systems and pacing technologies

NASA Technical Reports Server (NTRS)

Butterfield, A. J.; Garn, P. A.; King, C. B.; Queijo, M. J.

1990-01-01

The principal system features defined for the Advanced Technology Space Station are summarized and the 21 pacing technologies identified during the course of the study are described. The descriptions of system configurations were extracted from four previous study reports. The technological areas focus on those systems particular to all large spacecraft which generate artificial gravity by rotation. The summary includes a listing of the functions, crew requirements and electrical power demand that led to the studied configuration. The pacing technologies include the benefits of advanced materials, in-orbit assembly requirements, stationkeeping, evaluations of electrical power generation alternates, and life support systems. The descriptions of systems show the potential for synergies and identifies the beneficial interactions that can result from technological advances.

Advanced Radioisotope Power Systems Segmented Thermoelectric Research

NASA Technical Reports Server (NTRS)

Caillat, Thierry

2004-01-01

Flight times are long; - Need power systems with >15 years life. Mass is at an absolute premium; - Need power systems with high specific power and scalability. 3 orders of magnitude reduction in solar irradiance from Earth to Pluto. Nuclear power sources preferable. The Overall objective is to develop low mass, high efficiency, low-cost Advanced Radioisotope Power System with double the Specific Power and Efficiency over state-of-the-art Radioisotope Thermoelectric Generators (RTGs).

Nanomaterials for Advanced Life Support in Advanced Life Support in Space systems

NASA Technical Reports Server (NTRS)

Allada, Rama Kumar; Moloney, Padraig; Yowell, Leonard

2006-01-01

A viewgraph presentation describing nanomaterial research at NASA Johnson Space Center with a focus on advanced life support in space systems is shown. The topics include: 1) Introduction; 2) Research and accomplishments in Carbon Dioxide Removal; 3) Research and Accomplishments in Water Purification; and 4) Next Steps

Advanced Collaborative Environments Supporting Systems Integration and Design

DTIC Science & Technology

2003-03-01

concurrently view a virtual system or product model while maintaining natural, human communication . These virtual systems operate within a computer-generated...These environments allow multiple individuals to concurrently view a virtual system or product model while simultaneously maintaining natural, human ... communication . As a result, TARDEC researchers and system developers are using this advanced high-end visualization technology to develop future

Evaluation of NDOR's actuated advance warning systems.

DOT National Transportation Integrated Search

2011-12-01

"Driver behavior within the dilemma zone can be a major safety concern at high-speed signalized intersections. The : Nebraska Department of Roads (NDOR) has developed and implemented an actuated advance warning (AAW) dilemma : zone protection system....

Advanced technology and future earth-orbit transportation systems

NASA Technical Reports Server (NTRS)

Henry, B. Z.; Eldred, C. H.

1977-01-01

The paper is concerned with the identification and evaluation of technology developments which offer potential for high return on investment when applied to advanced transportation systems. These procedures are applied in a study of winged single-stage-to-orbit (SSTO) vehicles, which are considered feasible by the 1990s. Advanced technology is considered a key element in achieving improved economics, and near term investment in selected technology areas is recommended.

Space Shuttle Main Engine: Advanced Health Monitoring System

NASA Technical Reports Server (NTRS)

Singer, Chirs

1999-01-01

The main gola of the Space Shuttle Main Engine (SSME) Advanced Health Management system is to improve flight safety. To this end the new SSME has robust new components to improve the operating margen and operability. The features of the current SSME health monitoring system, include automated checkouts, closed loop redundant control system, catastropic failure mitigation, fail operational/ fail-safe algorithms, and post flight data and inspection trend analysis. The features of the advanced health monitoring system include: a real time vibration monitor system, a linear engine model, and an optical plume anomaly detection system. Since vibration is a fundamental measure of SSME turbopump health, it stands to reason that monitoring the vibration, will give some idea of the health of the turbopumps. However, how is it possible to avoid shutdown, when it is not necessary. A sensor algorithm has been developed which has been exposed to over 400 test cases in order to evaluate the logic. The optical plume anomaly detection (OPAD) has been developed to be a sensitive monitor of engine wear, erosion, and breakage.

Advanced rural transportation systems (ARTS) : strategic plan

DOT National Transportation Integrated Search

1997-08-01

This Strategic Plan has been developed for the Advanced Rural Transportation Systems (ARTS) portion of the ITS Program. The plan focuses on the Federal Government's role in developing rural ITS options and prudently managing emerging ITS technologies...

Advanced instrumentation concepts for environmental control subsystems

NASA Technical Reports Server (NTRS)

Yang, P. Y.; Schubert, F. H.; Gyorki, J. R.; Wynveen, R. A.

1978-01-01

Design, evaluation and demonstration of advanced instrumentation concepts for improving performance of manned spacecraft environmental control and life support systems were successfully completed. Concepts to aid maintenance following fault detection and isolation were defined. A computer-guided fault correction instruction program was developed and demonstrated in a packaged unit which also contains the operator/system interface.

The intelligent user interface for NASA's advanced information management systems

NASA Technical Reports Server (NTRS)

Campbell, William J.; Short, Nicholas, Jr.; Rolofs, Larry H.; Wattawa, Scott L.

1987-01-01

NASA has initiated the Intelligent Data Management Project to design and develop advanced information management systems. The project's primary goal is to formulate, design and develop advanced information systems that are capable of supporting the agency's future space research and operational information management needs. The first effort of the project was the development of a prototype Intelligent User Interface to an operational scientific database, using expert systems and natural language processing technologies. An overview of Intelligent User Interface formulation and development is given.

Advanced public transportation systems : the state of the art update 2006

DOT National Transportation Integrated Search

2006-03-30

This report is the latest in a series of State-of-the-Art reports, the last of which was published in December 2000. It contains the results of a high-level scan of the extent and character of the adoption and use of advanced technology in the provis...

Advanced Exploration Systems Water Architecture Study Interim Results

NASA Technical Reports Server (NTRS)

Sargusingh, Miriam J.

2013-01-01

The mission of the Advanced Exploration System (AES) Water Recovery Project (WRP) is to develop advanced water recovery systems that enable NASA human exploration missions beyond low Earth orbit (LEO). The primary objective of the AES WRP is to develop water recovery technologies critical to near-term missions beyond LEO. The secondary objective is to continue to advance mid-readiness-level technologies to support future NASA missions. An effort is being undertaken to establish the architecture for the AES Water Recovery System (WRS) that meets both near- and long-term objectives. The resultant architecture will be used to guide future technical planning, establish a baseline development roadmap for technology infusion, and establish baseline assumptions for integrated ground and on-orbit Environmental Control and Life Support Systems definition. This study is being performed in three phases. Phase I established the scope of the study through definition of the mission requirements and constraints, as well as identifying all possible WRS configurations that meet the mission requirements. Phase II focused on the near-term space exploration objectives by establishing an International Space Station-derived reference schematic for long-duration (>180 day) in-space habitation. Phase III will focus on the long-term space exploration objectives, trading the viable WRS configurations identified in Phase I to identify the ideal exploration WRS. The results of Phases I and II are discussed in this paper.

Airborne Advanced Reconfigurable Computer System (ARCS)

NASA Technical Reports Server (NTRS)

Bjurman, B. E.; Jenkins, G. M.; Masreliez, C. J.; Mcclellan, K. L.; Templeman, J. E.

1976-01-01

A digital computer subsystem fault-tolerant concept was defined, and the potential benefits and costs of such a subsystem were assessed when used as the central element of a new transport's flight control system. The derived advanced reconfigurable computer system (ARCS) is a triple-redundant computer subsystem that automatically reconfigures, under multiple fault conditions, from triplex to duplex to simplex operation, with redundancy recovery if the fault condition is transient. The study included criteria development covering factors at the aircraft's operation level that would influence the design of a fault-tolerant system for commercial airline use. A new reliability analysis tool was developed for evaluating redundant, fault-tolerant system availability and survivability; and a stringent digital system software design methodology was used to achieve design/implementation visibility.

The freight shuttle system : advancing commercial readiness.

DOT National Transportation Integrated Search

2011-01-01

This report summarizes the results of research aimed at advancing the commercial readiness of a new hybrid : mode of intermodal freight transportation called the Freight Shuttle System (FSS). The FSS represents a : unique combination of the best feat...

21 CFR 864.9900 - Cord blood processing system and storage container.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Cord blood processing system and storage container... Manufacture Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps) § 864.9900 Cord blood processing system and storage container. (a) Identification. A cord blood processing system and storage...

21 CFR 864.9900 - Cord blood processing system and storage container.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Cord blood processing system and storage container... Manufacture Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps) § 864.9900 Cord blood processing system and storage container. (a) Identification. A cord blood processing system and storage...

21 CFR 864.9900 - Cord blood processing system and storage container.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Cord blood processing system and storage container... Manufacture Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps) § 864.9900 Cord blood processing system and storage container. (a) Identification. A cord blood processing system and storage...

21 CFR 864.9900 - Cord blood processing system and storage container.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Cord blood processing system and storage container... Manufacture Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps) § 864.9900 Cord blood processing system and storage container. (a) Identification. A cord blood processing system and storage...

21 CFR 864.9900 - Cord blood processing system and storage container.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Cord blood processing system and storage container... Manufacture Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps) § 864.9900 Cord blood processing system and storage container. (a) Identification. A cord blood processing system and storage...

Systems engineering and integration: Advanced avionics laboratories

NASA Technical Reports Server (NTRS)

1990-01-01

In order to develop the new generation of avionics which will be necessary for upcoming programs such as the Lunar/Mars Initiative, Advanced Launch System, and the National Aerospace Plane, new Advanced Avionics Laboratories are required. To minimize costs and maximize benefits, these laboratories should be capable of supporting multiple avionics development efforts at a single location, and should be of a common design to support and encourage data sharing. Recent technological advances provide the capability of letting the designer or analyst perform simulations and testing in an environment similar to his engineering environment and these features should be incorporated into the new laboratories. Existing and emerging hardware and software standards must be incorporated wherever possible to provide additional cost savings and compatibility. Special care must be taken to design the laboratories such that real-time hardware-in-the-loop performance is not sacrificed in the pursuit of these goals. A special program-independent funding source should be identified for the development of Advanced Avionics Laboratories as resources supporting a wide range of upcoming NASA programs.

NASA's advanced space transportation system launch vehicles

NASA Technical Reports Server (NTRS)

Branscome, Darrell R.

1991-01-01

Some insight is provided into the advanced transportation planning and systems that will evolve to support long term mission requirements. The general requirements include: launch and lift capacity to low earth orbit (LEO); space based transfer systems for orbital operations between LEO and geosynchronous equatorial orbit (GEO), the Moon, and Mars; and Transfer vehicle systems for long duration deep space probes. These mission requirements are incorporated in the NASA Civil Needs Data Base. To accomplish these mission goals, adequate lift capacity to LEO must be available: to support science and application missions; to provide for construction of the Space Station Freedom; and to support resupply of personnel and supplies for its operations. Growth in lift capacity must be time phased to support an expanding mission model that includes Freedom Station, the Mission to Planet Earth, and an expanded robotic planetary program. The near term increase in cargo lift capacity associated with development of the Shuttle-C is addressed. The joint DOD/NASA Advanced Launch System studies are focused on a longer term new cargo capability that will significantly reduce costs of placing payloads in space.

Recent advances in systems metabolic engineering tools and strategies.

PubMed

Chae, Tong Un; Choi, So Young; Kim, Je Woong; Ko, Yoo-Sung; Lee, Sang Yup

2017-10-01

Metabolic engineering has been playing increasingly important roles in developing microbial cell factories for the production of various chemicals and materials to achieve sustainable chemical industry. Nowadays, many tools and strategies are available for performing systems metabolic engineering that allows systems-level metabolic engineering in more sophisticated and diverse ways by adopting rapidly advancing methodologies and tools of systems biology, synthetic biology and evolutionary engineering. As an outcome, development of more efficient microbial cell factories has become possible. Here, we review recent advances in systems metabolic engineering tools and strategies together with accompanying application examples. In addition, we describe how these tools and strategies work together in simultaneous and synergistic ways to develop novel microbial cell factories. Copyright © 2017 Elsevier Ltd. All rights reserved.

Recent advancements in the SQUID magnetospinogram system

NASA Astrophysics Data System (ADS)

Adachi, Yoshiaki; Kawai, Jun; Haruta, Yasuhiro; Miyamoto, Masakazu; Kawabata, Shigenori; Sekihara, Kensuke; Uehara, Gen

2017-06-01

In this study, a new superconducting quantum interference device (SQUID) biomagnetic measurement system known as magnetospinogram (MSG) is developed. The MSG system is used for observation of a weak magnetic field distribution induced by the neural activity of the spinal cord over the body surface. The current source reconstruction for the observed magnetic field distribution provides noninvasive functional imaging of the spinal cord, which enables medical personnel to diagnose spinal cord diseases more accurately. The MSG system is equipped with a uniquely shaped cryostat and a sensor array of vector-type SQUID gradiometers that are designed to detect the magnetic field from deep sources across a narrow observation area over the body surface of supine subjects. The latest prototype of the MSG system is already applied in clinical studies to develop a diagnosis protocol for spinal cord diseases. Advancements in hardware and software for MSG signal processing and cryogenic components aid in effectively suppressing external magnetic field noise and reducing the cost of liquid helium that act as barriers with respect to the introduction of the MSG system to hospitals. The application of the MSG system is extended to various biomagnetic applications in addition to spinal cord functional imaging given the advantages of the MSG system for investigating deep sources. The study also includes a report on the recent advancements of the SQUID MSG system including its peripheral technologies and wide-spread applications.

Glycoengineering in CHO Cells: Advances in Systems Biology.

PubMed

Tejwani, Vijay; Andersen, Mikael R; Nam, Jong Hyun; Sharfstein, Susan T

2018-03-01

For several decades, glycoprotein biologics have been successfully produced from Chinese hamster ovary (CHO) cells. The therapeutic efficacy and potency of glycoprotein biologics are often dictated by their post-translational modifications, particularly glycosylation, which unlike protein synthesis, is a non-templated process. Consequently, both native and recombinant glycoprotein production generate heterogeneous mixtures containing variable amounts of different glycoforms. Stability, potency, plasma half-life, and immunogenicity of the glycoprotein biologic are directly influenced by the glycoforms. Recently, CHO cells have also been explored for production of therapeutic glycosaminoglycans (e.g., heparin), which presents similar challenges as producing glycoproteins biologics. Approaches to controlling heterogeneity in CHO cells and directing the biosynthetic process toward desired glycoforms are not well understood. A systems biology approach combining different technologies is needed for complete understanding of the molecular processes accounting for this variability and to open up new venues in cell line development. In this review, we describe several advances in genetic manipulation, modeling, and glycan and glycoprotein analysis that together will provide new strategies for glycoengineering of CHO cells with desired or enhanced glycosylation capabilities. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Conceptual definition of a technology development mission for advanced solar dynamic power systems

NASA Technical Reports Server (NTRS)

Migra, R. P.

1986-01-01

An initial conceptual definition of a technology development mission for advanced solar dynamic power systems is provided, utilizing a space station to provide a dedicated test facility. The advanced power systems considered included Brayton, Stirling, and liquid metal Rankine systems operating in the temperature range of 1040 to 1400 K. The critical technologies for advanced systems were identified by reviewing the current state of the art of solar dynamic power systems. The experimental requirements were determined by planning a system test of a 20 kWe solar dynamic power system on the space station test facility. These requirements were documented via the Mission Requirements Working Group (MRWG) and Technology Development Advocacy Group (TDAG) forms. Various concepts or considerations of advanced concepts are discussed. A preliminary evolutionary plan for this technology development mission was prepared.

System Design Techniques for Reducing the Power Requirements of Advanced life Support Systems

NASA Technical Reports Server (NTRS)

Finn, Cory; Levri, Julie; Pawlowski, Chris; Crawford, Sekou; Luna, Bernadette (Technical Monitor)

2000-01-01

The high power requirement associated with overall operation of regenerative life support systems is a critical Z:p technological challenge. Optimization of individual processors alone will not be sufficient to produce an optimized system. System studies must be used in order to improve the overall efficiency of life support systems. Current research efforts at NASA Ames Research Center are aimed at developing approaches for reducing system power and energy usage in advanced life support systems. System energy integration and energy reuse techniques are being applied to advanced life support, in addition to advanced control methods for efficient distribution of power and thermal resources. An overview of current results of this work will be presented. The development of integrated system designs that reuse waste heat from sources such as crop lighting and solid waste processing systems will reduce overall power and cooling requirements. Using an energy integration technique known as Pinch analysis, system heat exchange designs are being developed that match hot and cold streams according to specific design principles. For various designs, the potential savings for power, heating and cooling are being identified and quantified. The use of state-of-the-art control methods for distribution of resources, such as system cooling water or electrical power, will also reduce overall power and cooling requirements. Control algorithms are being developed which dynamically adjust the use of system resources by the various subsystems and components in order to achieve an overall goal, such as smoothing of power usage and/or heat rejection profiles, while maintaining adequate reserves of food, water, oxygen, and other consumables, and preventing excessive build-up of waste materials. Reductions in the peak loading of the power and thermal systems will lead to lower overall requirements. Computer simulation models are being used to test various control system designs.

Advanced processing for high-bandwidth sensor systems

NASA Astrophysics Data System (ADS)

Szymanski, John J.; Blain, Phil C.; Bloch, Jeffrey J.; Brislawn, Christopher M.; Brumby, Steven P.; Cafferty, Maureen M.; Dunham, Mark E.; Frigo, Janette R.; Gokhale, Maya; Harvey, Neal R.; Kenyon, Garrett; Kim, Won-Ha; Layne, J.; Lavenier, Dominique D.; McCabe, Kevin P.; Mitchell, Melanie; Moore, Kurt R.; Perkins, Simon J.; Porter, Reid B.; Robinson, S.; Salazar, Alfonso; Theiler, James P.; Young, Aaron C.

2000-11-01

Compute performance and algorithm design are key problems of image processing and scientific computing in general. For example, imaging spectrometers are capable of producing data in hundreds of spectral bands with millions of pixels. These data sets show great promise for remote sensing applications, but require new and computationally intensive processing. The goal of the Deployable Adaptive Processing Systems (DAPS) project at Los Alamos National Laboratory is to develop advanced processing hardware and algorithms for high-bandwidth sensor applications. The project has produced electronics for processing multi- and hyper-spectral sensor data, as well as LIDAR data, while employing processing elements using a variety of technologies. The project team is currently working on reconfigurable computing technology and advanced feature extraction techniques, with an emphasis on their application to image and RF signal processing. This paper presents reconfigurable computing technology and advanced feature extraction algorithm work and their application to multi- and hyperspectral image processing. Related projects on genetic algorithms as applied to image processing will be introduced, as will the collaboration between the DAPS project and the DARPA Adaptive Computing Systems program. Further details are presented in other talks during this conference and in other conferences taking place during this symposium.

MATCON MODIFIED ASPHALT COVER CONTAINMENT SYSTEM DEMONSTRATION

EPA Science Inventory

In order to make improvements to conventional paving asphalt to make it more suitable for containment applications, Wilder Construction Co. of Everett, WA offers MatCon, a polymer modified asphalt system comprised of proprietary binder, when coupled with a selected aggregate type...

The High-Repetition-Rate Advanced Petawatt Laser System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haefner, Constantin; Jarboe, Jeff; Koubikova, Luci

2017-02-02

The High-Repetition-Rate Advanced Petawatt Laser System (HAPLS), being developed at Lawrence Livermore National Laboratory (LLNL), recently completed a significant milestone: demonstration of continuous operation of an all diode-pumped, high-energy femtosecond petawatt laser system. The system is now ready for delivery and integration at the European Extreme Light Infrastructure Beamlines facility project (ELI Beamlines) in the Czech Republic.

Advanced optical blade tip clearance measurement system

NASA Technical Reports Server (NTRS)

Ford, M. J.; Honeycutt, R. E.; Nordlund, R. E.; Robinson, W. W.

1978-01-01

An advanced electro-optical system was developed to measure single blade tip clearances and average blade tip clearances between a rotor and its gas path seal in an operating gas turbine engine. This system is applicable to fan, compressor, and turbine blade tip clearance measurement requirements, and the system probe is particularly suitable for operation in the extreme turbine environment. A study of optical properties of blade tips was conducted to establish measurement system application limitations. A series of laboratory tests was conducted to determine the measurement system's operational performance characteristics and to demonstrate system capability under simulated operating gas turbine environmental conditions. Operational and environmental performance test data are presented.

The development of advanced manufacturing systems

NASA Astrophysics Data System (ADS)

Doumeingts, Guy; Vallespir, Bruno; Darricau, Didier; Roboam, Michel

Various methods for the design of advanced manufacturing systems (AMSs) are reviewed. The specifications for AMSs and problems inherent in their development are first discussed. Three models, the Computer Aided Manufacturing-International model, the National Bureau of Standards model, and the GRAI model, are considered in detail. Hierarchical modeling tools such as structured analysis and design techniques, Petri nets, and the Icam definition method are used in the development of integrated manufacturing models. Finally, the GRAI method is demonstrated in the design of specifications for the production management system of the Snecma AMS.

Advanced laser stratospheric monitoring systems analyses

NASA Technical Reports Server (NTRS)

Larsen, J. C.

1984-01-01

This report describes the software support supplied by Systems and Applied Sciences Corporation for the study of Advanced Laser Stratospheric Monitoring Systems Analyses under contract No. NAS1-15806. This report discusses improvements to the Langley spectroscopic data base, development of LHS instrument control software and data analyses and validation software. The effect of diurnal variations on the retrieved concentrations of NO, NO2 and C L O from a space and balloon borne measurement platform are discussed along with the selection of optimum IF channels for sensing stratospheric species from space.

Conceptual design study for an advanced cab and visual system, volume 2

NASA Technical Reports Server (NTRS)

Rue, R. J.; Cyrus, M. L.; Garnett, T. A.; Nachbor, J. W.; Seery, J. A.; Starr, R. L.

1980-01-01

The performance, design, construction and testing requirements are defined for developing an advanced cab and visual system. The rotorcraft system integration simulator is composed of the advanced cab and visual system and the rotorcraft system motion generator, and is part of an existing simulation facility. User's applications for the simulator include rotorcraft design development, product improvement, threat assessment, and accident investigation.

Advanced long term cryogenic storage systems

NASA Technical Reports Server (NTRS)

Brown, Norman S.

1987-01-01

Long term, cryogenic fluid storage facilities will be required to support future space programs such as the space-based Orbital Transfer Vehicle (OTV), Telescopes, and Laser Systems. An orbital liquid oxygen/liquid hydrogen storage system with an initial capacity of approximately 200,000 lb will be required. The storage facility tank design must have the capability of fluid acquisition in microgravity and limit cryogen boiloff due to environmental heating. Cryogenic boiloff management features, minimizing Earth-to-orbit transportation costs, will include advanced thick multilayer insulation/integrated vapor cooled shield concepts, low conductance support structures, and refrigeration/reliquefaction systems. Contracted study efforts are under way to develop storage system designs, technology plans, test article hardware designs, and develop plans for ground/flight testing.

Self-contained clothing system provides protection against hazardous environments

NASA Technical Reports Server (NTRS)

1966-01-01

Self-contained clothing system protects personnel against hazardous environments. The clothing has an environmental control system and a complete protection envelope consisting of an outer garment, inner garment, underwear, boots, gloves, and helmet.

WAATS: A computer program for Weights Analysis of Advanced Transportation Systems

NASA Technical Reports Server (NTRS)

Glatt, C. R.

1974-01-01

A historical weight estimating technique for advanced transportation systems is presented. The classical approach to weight estimation is discussed and sufficient data is presented to estimate weights for a large spectrum of flight vehicles including horizontal and vertical takeoff aircraft, boosters and reentry vehicles. A computer program, WAATS (Weights Analysis for Advanced Transportation Systems) embracing the techniques discussed has been written and user instructions are presented. The program was developed for use in the ODIN (Optimal Design Integration System) system.

Forest fire advanced system technology (FFAST) conceptual design study

NASA Technical Reports Server (NTRS)

Nichols, J. David; Warren, John R.

1987-01-01

The National Aeronautics and Space Administration's Jet Propulsion Laboratory (JPL) and the U.S. Department of Agriculture (USDA) Forest Service completed a conceptual design study that defined an integrated forest fire detection and mapping system that will be based upon technology available in the 1990s. Potential system configuration options in emerging and advanced technologies related to the conceptual design were identified and recommended for inclusion as preferred system components. System component technologies identified for an end-to-end system include airborne mounted, thermal infrared (IR) linear array detectors, automatic onboard georeferencing and signal processing, geosynchronous satellite communications links, and advanced data integration and display. Potential system configuration options were developed and examined for possible inclusion in the preferred system configuration. The preferred system configuration will provide increased performance and be cost effective over the system currently in use. Forest fire management user requirements and the system component emerging technologies were the basis for the system configuration design. The conceptual design study defined the preferred system configuration that warrants continued refinement and development, examined economic aspects of the current and preferred system, and provided preliminary cost estimates for follow-on system prototype development.

Microprocessor controlled advanced battery management systems

NASA Technical Reports Server (NTRS)

Payne, W. T.

1978-01-01

The advanced battery management system described uses the capabilities of an on-board microprocessor to: (1) monitor the state of the battery on a cell by cell basis; (2) compute the state of charge of each cell; (3) protect each cell from reversal; (4) prevent overcharge on each individual cell; and (5) control dual rate reconditioning to zero volts per cell.

Advanced Data Acquisition and Telemetry System

NASA Image and Video Library

2016-09-15

The Advanced Data Acquisition and Telemetry System team includes front row from left Mario Soto, Sam Habbal, Tiffany Titas, RIchard Hang, Randy Torres, Thang Quach, Otto Schnarr, Matthew Waldersen, Karen Estes, Andy Olvera, Stanley Wertenberger and Rick Cordes. In the second row from left are John Atherly, Doug Boston, Tom Horn, Brady Rennie, Chris Birkinbine, Jim McNally, Martin Munday and Tony Lorek.

Systems-Level Synthetic Biology for Advanced Biofuel Production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruffing, Anne; Jensen, Travis J.; Strickland, Lucas Marshall

2015-03-01

Cyanobacteria have been shown to be capable of producing a variety of advanced biofuels; however, product yields remain well below those necessary for large scale production. New genetic tools and high throughput metabolic engineering techniques are needed to optimize cyanobacterial metabolisms for enhanced biofuel production. Towards this goal, this project advances the development of a multiple promoter replacement technique for systems-level optimization of gene expression in a model cyanobacterial host: Synechococcus sp. PCC 7002. To realize this multiple-target approach, key capabilities were developed, including a high throughput detection method for advanced biofuels, enhanced transformation efficiency, and genetic tools for Synechococcusmore » sp. PCC 7002. Moreover, several additional obstacles were identified for realization of this multiple promoter replacement technique. The techniques and tools developed in this project will help to enable future efforts in the advancement of cyanobacterial biofuels.« less

Port-of-entry advanced sorting system (PASS) operational test

DOT National Transportation Integrated Search

1998-12-01

In 1992 the Oregon Department of Transportation undertook an operational test of the Port-of-Entry Advanced Sorting System (PASS), which uses a two-way communication automatic vehicle identification system, integrated with weigh-in-motion, automatic ...

Engineered Polymers for Advanced Drug Delivery

PubMed Central

Kim, Sungwon; Kim, Jong-Ho; Jeon, Oju; Kwon, Ick Chan; Park, Kinam

2009-01-01

Engineered polymers have been utilized for developing advanced drug delivery systems. The development of such polymers has caused advances in polymer chemistry, which, in turn, has resulted in smart polymers that can respond to changes in environmental condition, such as temperature, pH, and biomolecules. The responses vary widely from swelling/deswelling to degradation. Drug-polymer conjugates and drug-containing nano/micro-particles have been used for drug targeting. Engineered polymers and polymeric systems have also been used in new areas, such as molecular imaging as well as in nanotechnology. This review examines the engineered polymers that have been used as traditional drug delivery and as more recent applications in nanotechnology. PMID:18977434

Synthetic biology: advancing the design of diverse genetic systems

PubMed Central

Wang, Yen-Hsiang; Wei, Kathy Y.; Smolke, Christina D.

2013-01-01

A main objective of synthetic biology is to make the process of designing genetically-encoded biological systems more systematic, predictable, robust, scalable, and efficient. The examples of genetic systems in the field vary widely in terms of operating hosts, compositional approaches, and network complexity, ranging from a simple genetic switch to search-and-destroy systems. While significant advances in synthesis capabilities support the potential for the implementation of pathway- and genome-scale programs, several design challenges currently restrict the scale of systems that can be reasonably designed and implemented. Synthetic biology offers much promise in developing systems to address challenges faced in manufacturing, the environment and sustainability, and health and medicine, but the realization of this potential is currently limited by the diversity of available parts and effective design frameworks. As researchers make progress in bridging this design gap, advances in the field hint at ever more diverse applications for biological systems. PMID:23413816

An airline study of advanced technology requirements for advanced high speed commercial engines. 3: Propulsion system requirements

NASA Technical Reports Server (NTRS)

Sallee, G. P.

1973-01-01

The advanced technology requirements for an advanced high speed commercial transport engine are presented. The results of the phase 3 effort cover the requirements and objectives for future aircraft propulsion systems. These requirements reflect the results of the Task 1 and 2 efforts and serve as a baseline for future evaluations, specification development efforts, contract/purchase agreements, and operational plans for future subsonic commercial engines. This report is divided into five major sections: (1) management objectives for commercial propulsion systems, (2) performance requirements for commercial transport propulsion systems, (3) design criteria for future transport engines, (4) design requirements for powerplant packages, and (5) testing.

Potentials of Advanced Database Technology for Military Information Systems

DTIC Science & Technology

2001-04-01

UNCLASSIFIED Defense Technical Information Center Compilation Part Notice ADP010866 TITLE: Potentials of Advanced Database Technology for Military... Technology for Military Information Systems Sunil Choennia Ben Bruggemanb a National Aerospace Laboratory, NLR, P.O. Box 90502, 1006 BM Amsterdam...application of advanced information tech- nology, including database technology , as underpin- actions X and Y as dangerous or not? ning is

Advanced vehicle systems assessment. Volume 2: Subsystems assessment

NASA Technical Reports Server (NTRS)

Hardy, K.

1985-01-01

Volume 2 (Subsystems Assessment) is part of a five-volume report entitled Advanced Vehicle Systems Assessment. Volume 2 presents the projected performance capabilities and cost characteristics of applicable subsystems, considering an additional decade of development. Subsystems of interest include energy storage and conversion devices as well as the necessary powertrain components and vehicle subsystems. Volume 2 also includes updated battery information based on the assessment of an independent battery review board (with the aid of subcontractor reports on advanced battery characteristics).

Materials Requirements for Advanced Propulsion Systems

NASA Technical Reports Server (NTRS)

Whitaker, Ann F.; Cook, Mary Beth; Clinton, R. G., Jr.

2005-01-01

NASA's mission to "reach the Moon and Mars" will be obtained only if research begins now to develop materials with expanded capabilities to reduce mass, cost and risk to the program. Current materials cannot function satisfactorily in the deep space environments and do not meet the requirements of long term space propulsion concepts for manned missions. Directed research is needed to better understand materials behavior for optimizing their processing. This research, generating a deeper understanding of material behavior, can lead to enhanced implementation of materials for future exploration vehicles. materials providing new approaches for manufacture and new options for In response to this need for more robust materials, NASA's Exploration Systems Mission Directorate (ESMD) has established a strategic research initiative dedicated to materials development supporting NASA's space propulsion needs. The Advanced Materials for Exploration (AME) element directs basic and applied research to understand material behavior and develop improved materials allowing propulsion systems to operate beyond their current limitations. This paper will discuss the approach used to direct the path of strategic research for advanced materials to ensure that the research is indeed supportive of NASA's future missions to the moon, Mars, and beyond.

Advanced public transportation systems : the state of the art update 2000

DOT National Transportation Integrated Search

2000-12-01

This report documents work performed under FTA's Advanced Public Transportation Systems (APTS) Program, a program structured to undertake research and development of innovative applications of advanced navigation, communication, information, computer...

Advanced Public Transportation Systems. Technical Assistance Brief 2

DOT National Transportation Integrated Search

1993-01-01

The Advanced Public Transportation Systems (APTS) Program requires evaluation : of pilot projects. This technical assistance brief discusses the guidelines set : for developing evaluation framework and methodology for local projects. 4p.

Advanced nozzle and engine components test facility

NASA Technical Reports Server (NTRS)

Beltran, Luis R.; Delroso, Richard L.; Delrosario, Ruben

1992-01-01

A test facility for conducting scaled advanced nozzle and engine component research is described. The CE-22 test facility, located in the Engine Research Building of the NASA Lewis Research Center, contains many systems for the economical testing of advanced scale-model nozzles and engine components. The combustion air and altitude exhaust systems are described. Combustion air can be supplied to a model up to 40 psig for primary air flow, and 40, 125, and 450 psig for secondary air flow. Altitude exhaust can be simulated up to 48,000 ft, or the exhaust can be atmospheric. Descriptions of the multiaxis thrust stand, a color schlieren flow visualization system used for qualitative flow analysis, a labyrinth flow measurement system, a data acquisition system, and auxiliary systems are discussed. Model recommended design information and temperature and pressure instrumentation recommendations are included.

Advanced Launch System (ALS) actuation and power systems impact operability and cost

NASA Technical Reports Server (NTRS)

Sundberg, Gale R.

1990-01-01

To obtain the Advanced Launch System (ALS) primary goals of reduced costs and improved operability, there must be significant reductions in the launch operations and servicing requirements relative to current vehicle designs and practices. One of the primary methods for achieving these goals is by using vehicle electrical power system and controls for all actuation and avionics requirements. A brief status review of the ALS and its associated Advanced Development Program is presented to demonstrate maturation of those technologies that will help meet the overall operability and cost goals. The electric power and actuation systems are highlighted as a specific technology ready not only to meet the stringent ALS goals (cryogenic field valves and thrust vector controls with peak power demands to 75 hp), but also those of other launch vehicles, military and civilian aircraft, lunar/Martian vehicles, and a multitude of commercial applications.

Advanced telepresence surgery system development.

PubMed

Jensen, J F; Hill, J W

1996-01-01

SRI International is currently developing a prototype remote telepresence surgery system, for the Advanced Research Projects Agency (ARPA), that will bring life-saving surgical care to wounded soldiers in the zone of combat. Remote surgery also has potentially important applications in civilian medicine. In addition, telepresence will find wide medical use in local surgery, in endoscopic, laparoscopic, and microsurgery applications. Key elements of the telepresence technology now being developed for ARPA, including the telepresence surgeon's workstation (TSW) and associated servo control systems, will have direct application to these areas of minimally invasive surgery. The TSW technology will also find use in surgical training, where it will provide an immersive visual and haptic interface for interaction with computer-based anatomical models. In this paper, we discuss our ongoing development of the MEDFAST telesurgery system, focusing on the TSW man-machine interface and its associated servo control electronics.

Development of advanced fuel cell system

NASA Technical Reports Server (NTRS)

Grevstad, P. E.

1972-01-01

Weight, life and performance characteristics optimization of hydrogen-oxygen fuel cell power systems were considered. A promising gold alloy cathode catalyst was identified and tested in a cell for 5,000 hours. The compatibility characteristics of candidate polymer structural materials were measured after exposure to electrolyte and water vapor for 8,000 hours. Lightweight cell designs were prepared and fabrication techniques to produce them were developed. Testing demonstrated that predicted performance was achieved. Lightweight components for passive product water removal and evaporative cooling of cells were demonstrated. Systems studies identified fuel cell powerplant concepts for meeting the requirements of advanced spacecraft.

Advanced Treatment of Pesticide-Containing Wastewater Using Fenton Reagent Enhanced by Microwave Electrodeless Ultraviolet

PubMed Central

Cheng, Gong; Lin, Jing; Lu, Jian; Zhao, Xi; Cai, Zhengqing; Fu, Jie

2015-01-01

The photo-Fenton reaction is a promising method to treat organic contaminants in water. In this paper, a Fenton reagent enhanced by microwave electrodeless ultraviolet (MWEUV/Fenton) method was proposed for advanced treatment of nonbiodegradable organic substance in pesticide-containing biotreated wastewater. MWEUV lamp was found to be more effective for chemical oxygen demand (COD) removal than commercial mercury lamps in the Fenton process. The pseudo-first order kinetic model can well describe COD removal from pesticide-containing wastewater by MWEUV/Fenton, and the apparent rate constant (k) was 0.0125 min−1. The optimal conditions for MWEUV/Fenton process were determined as initial pH of 5, Fe2+ dosage of 0.8 mmol/L, and H2O2 dosage of 100 mmol/L. Under the optimal conditions, the reaction exhibited high mineralization degrees of organics, where COD and dissolved organic carbon (DOC) concentration decreased from 183.2 mg/L to 36.9 mg/L and 43.5 mg/L to 27.8 mg/L, respectively. Three main pesticides in the wastewater, as Dimethoate, Triazophos, and Malathion, were completely removed by the MWEUV/Fenton process within 120 min. The high degree of pesticides decomposition and mineralization was proved by the detected inorganic anions. PMID:26347877

Advanced public transportation systems: the state of the art, update '92

DOT National Transportation Integrated Search

1992-03-01

This report documents one of the components of FTA's Advanced Public Transportation Systems (APTS) Program, a program structured to undertake research and development of innovative applications of advanced navigation, information, and communication t...

Advanced public transportation systems : the state of the art, update '94

DOT National Transportation Integrated Search

1994-01-01

This report documents one of the components of FTA's Advanced Public Transportation Systems (APTS) Program, a program structured to undertake research and development of innovative applications of advanced navigation, information, and communication t...

Distributed Containment Control for Multiple Unknown Second-Order Nonlinear Systems With Application to Networked Lagrangian Systems.

PubMed

Mei, Jie; Ren, Wei; Li, Bing; Ma, Guangfu

2015-09-01

In this paper, we consider the distributed containment control problem for multiagent systems with unknown nonlinear dynamics. More specifically, we focus on multiple second-order nonlinear systems and networked Lagrangian systems. We first study the distributed containment control problem for multiple second-order nonlinear systems with multiple dynamic leaders in the presence of unknown nonlinearities and external disturbances under a general directed graph that characterizes the interaction among the leaders and the followers. A distributed adaptive control algorithm with an adaptive gain design based on the approximation capability of neural networks is proposed. We present a necessary and sufficient condition on the directed graph such that the containment error can be reduced as small as desired. As a byproduct, the leaderless consensus problem is solved with asymptotical convergence. Because relative velocity measurements between neighbors are generally more difficult to obtain than relative position measurements, we then propose a distributed containment control algorithm without using neighbors' velocity information. A two-step Lyapunov-based method is used to study the convergence of the closed-loop system. Next, we apply the ideas to deal with the containment control problem for networked unknown Lagrangian systems under a general directed graph. All the proposed algorithms are distributed and can be implemented using only local measurements in the absence of communication. Finally, simulation examples are provided to show the effectiveness of the proposed control algorithms.

Advanced resin systems and 3D textile preforms for low cost composite structures

NASA Technical Reports Server (NTRS)

Shukla, J. G.; Bayha, T. D.

1993-01-01

Advanced resin systems and 3D textile preforms are being evaluated at Lockheed Aeronautical Systems Company (LASC) under NASA's Advanced Composites Technology (ACT) Program. This work is aimed towards the development of low-cost, damage-tolerant composite fuselage structures. Resin systems for resin transfer molding and powder epoxy towpreg materials are being evaluated for processability, performance and cost. Three developmental epoxy resin systems for resin transfer molding (RTM) and three resin systems for powder towpregging are being investigated. Various 3D textile preform architectures using advanced weaving and braiding processes are also being evaluated. Trials are being conducted with powdered towpreg, in 2D weaving and 3D braiding processes for their textile processability and their potential for fabrication in 'net shape' fuselage structures. The progress in advanced resin screening and textile preform development is reviewed here.

Removal of organic wastewater contaminants in septic systems using advanced treatment technologies

USGS Publications Warehouse

Wilcox, J.D.; Bahr, J.M.; Hedman, C.J.; Hemming, J.D.C.; Barman, M.A.E.; Bradbury, K.R.

2009-01-01

The detection of pharmaceuticals and other organic wastewater contaminants (OWCs) in ground water and surface-water bodies has raised concerns about the possible ecological impacts of these compounds on nontarget organisms. On-site wastewater treatment systems represent a potentially significant route of entry for organic contaminants to the environment. In this study, effluent samples were collected and analyzed from conventional septic systems and from systems using advanced treatment technologies. Six of 13 target compounds were detected in effluent from at least one septic system. Caffeine, paraxanthine, and acetaminophen were the most frequently detected compounds, and estrogenic activity was detected in 14 of 15 systems. The OWC concentrations were significantly lower in effluent after sand filtration (p < 0.01) or aerobic treatment (p < 0.05) as compared with effluent that had not undergone advanced treatment. In general, concentrations in conventional systems were comparable to those measured in previous studies of municipal wastewater treatment plant (WWTP) influent, and concentrations in systems after advanced treatment were comparable to previously measured concentrations in WWTP effluent. These data indicate that septic systems using advanced treatment can reduce OWCs in treated effluent to similar concentrations as municipal WWTPs. Copyright ?? 2009 by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America. All rights reserved.

Advanced Space Surface Systems Operations

NASA Technical Reports Server (NTRS)

Huffaker, Zachary Lynn; Mueller, Robert P.

2014-01-01

The importance of advanced surface systems is becoming increasingly relevant in the modern age of space technology. Specifically, projects pursued by the Granular Mechanics and Regolith Operations (GMRO) Lab are unparalleled in the field of planetary resourcefulness. This internship opportunity involved projects that support properly utilizing natural resources from other celestial bodies. Beginning with the tele-robotic workstation, mechanical upgrades were necessary to consider for specific portions of the workstation consoles and successfully designed in concept. This would provide more means for innovation and creativity concerning advanced robotic operations. Project RASSOR is a regolith excavator robot whose primary objective is to mine, store, and dump regolith efficiently on other planetary surfaces. Mechanical adjustments were made to improve this robot's functionality, although there were some minor system changes left to perform before the opportunity ended. On the topic of excavator robots, the notes taken by the GMRO staff during the 2013 and 2014 Robotic Mining Competitions were effectively organized and analyzed for logistical purposes. Lessons learned from these annual competitions at Kennedy Space Center are greatly influential to the GMRO engineers and roboticists. Another project that GMRO staff support is Project Morpheus. Support for this project included successfully producing mathematical models of the eroded landing pad surface for the vertical testbed vehicle to predict a timeline for pad reparation. And finally, the last project this opportunity made contribution to was Project Neo, a project exterior to GMRO Lab projects, which focuses on rocket propulsion systems. Additions were successfully installed to the support structure of an original vertical testbed rocket engine, thus making progress towards futuristic test firings in which data will be analyzed by students affiliated with Rocket University. Each project will be explained in

Freight advanced traveler information system : concept of operations.

DOT National Transportation Integrated Search

2012-08-01

This report describes a Concept of Operations (ConOps) for a Freight Advanced Traveler Information System (FRATIS). The ConOps describes the goals, functions, key concepts, user classes, high-level architecture, operational scenarios, operational pol...

Advanced hybrid vehicle propulsion system study

NASA Technical Reports Server (NTRS)

Schwarz, R.

1982-01-01

Results are presented of a study of an advanced heat engine/electric automotive hybrid propulsion system. The system uses a rotary stratified charge engine and ac motor/controller in a parallel hybrid configuration. The three tasks of the study were (1) parametric studies involving five different vehicle types, (2) design trade-off studies to determine the influence of various vehicle and propulsion system paramaters on system performance fuel economy and cost, and (3) a conceptual design establishing feasibility at the selected approach. Energy consumption for the selected system was .034 1/km (61.3 mpg) for the heat engine and .221 kWh/km (.356 kWh/mi) for the electric power system over a modified J227 a schedule D driving cycle. Life cycle costs were 7.13 cents/km (11.5 cents/mi) at $2/gal gasoline and 7 cents/kWh electricity for 160,000 km (100,000 mi) life.

NASDA's Advanced On-Line System (ADOLIS)

NASA Technical Reports Server (NTRS)

Yamamoto, Yoshikatsu; Hara, Hideo; Yamada, Shigeo; Hirata, Nobuyuki; Komatsu, Shigenori; Nishihata, Seiji; Oniyama, Akio

1993-01-01

Spacecraft operations including ground system operations are generally realized by various large or small scale group work which is done by operators, engineers, managers, users and so on, and their positions are geographically distributed in many cases. In face-to-face work environments, it is easy for them to understand each other. However, in distributed work environments which need communication media, if only using audio, they become estranged from each other and lose interest in and continuity of work. It is an obstacle to smooth operation of spacecraft. NASDA has developed an experimental model of a new real-time operation control system called 'ADOLIS' (ADvanced On-Line System) adopted to such a distributed environment using a multi-media system dealing with character, figure, image, handwriting, video and audio information which is accommodated to operation systems of a wide range including spacecraft and ground systems. This paper describes the results of the development of the experimental model.

City of Fort Collins advanced traffic management system : final report

DOT National Transportation Integrated Search

2009-01-01

The Fort Collins Advance Traffic Management System (ATMS) was a FY01 earmarked project. The objective of the overall project was to rebuild the Citys entire traffic management system to utilize and provide Intelligent Transportation System (ITS) c...

Advanced Hepatocellular Carcinoma: Which Staging Systems Best Predict Prognosis?

PubMed Central

Huitzil-Melendez, Fidel-David; Capanu, Marinela; O'Reilly, Eileen M.; Duffy, Austin; Gansukh, Bolorsukh; Saltz, Leonard L.; Abou-Alfa, Ghassan K.

2010-01-01

Purpose The purpose of cancer staging systems is to accurately predict patient prognosis. The outcome of advanced hepatocellular carcinoma (HCC) depends on both the cancer stage and the extent of liver dysfunction. Many staging systems that include both aspects have been developed. It remains unknown, however, which of these systems is optimal for predicting patient survival. Patients and Methods Patients with advanced HCC treated over a 5-year period at Memorial Sloan-Kettering Cancer Center were identified from an electronic medical record database. Patients with sufficient data for utilization in all staging systems were included. TNM sixth edition, Okuda, Barcelona Clinic Liver Cancer (BCLC), Cancer of the Liver Italian Program (CLIP), Chinese University Prognostic Index (CUPI), Japan Integrated Staging (JIS), and Groupe d'Etude et de Traitement du Carcinome Hepatocellulaire (GETCH) systems were ranked on the basis of their accuracy at predicting survival by using concordance index (c-index). Other independent prognostic variables were also identified. Results Overall, 187 eligible patients were identified and were staged by using the seven staging systems. CLIP, CUPI, and GETCH were the three top-ranking staging systems. BCLC and TNM sixth edition lacked any meaningful prognostic discrimination. Performance status, AST, abdominal pain, and esophageal varices improved the discriminatory ability of CLIP. Conclusion In our selected patient population, CLIP, CUPI, and GETCH were the most informative staging systems in predicting survival in patients with advanced HCC. Prospective validation is required to determine if they can be accurately used to stratify patients in clinical trials and to direct the appropriate need for systemic therapy versus best supportive care. BCLC and TNM sixth edition were not helpful in predicting survival outcome, and their use is not supported by our data. PMID:20458042

Heating and Cooling System Design for a Modern Transportable Container

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berger, Jason E.

Sandia National Laboratories (SNL) has been tasked with the design of a modern transportable container (MTC) for use in high reliability transportation environments. The container is required to transport cargo capable of generating its own heat and operate under the United States’ climatic extremes. In response to these requirements, active heating and cooling is necessary to maintain a controlled environment inside the container. The following thesis project documents the design of an active heating, active cooling, and combined active heating and cooling system (now referred to as active heating and cooling systems) through computational thermal analyses, scoping of commercial systemmore » options, and mechanical integration with the container’s structure.« less

Opportunities for development of advanced large cargo aircraft

NASA Technical Reports Server (NTRS)

Whitehead, A. H., Jr.

1976-01-01

A critical review of the history, current state of the art, and future prospects for cargo aircraft systems indicates that three of the major advantages of air cargo are rapid delivery, ability to bridge geographical boundaries, and capability to provide a flexible market response. Foreseeable advances in large aircraft development offer even greater profit potential by increasing the payload ton-miles per pound of fuel. Intermodal containers and handling systems and computerized control and billing may be key ingredients. Details of a NASA program for large aircraft systems technology are outlined, which includes systems studies, research and technology investigations, and determination of the need for critical flight experiments. Innovative advanced technologies and configuration concepts are discussed. Numerous illustrations supplement the text.

The impact of gendered organizational systems on women's career advancement.

PubMed

O'Neil, Deborah A; Hopkins, Margaret M

2015-01-01

In this Perspective article we propose that in order to pave the way for women's career advancement into the senior ranks of organizations, attention must be directed at the systemic norms and structures that drive the gendered nature of the workplace. A focus on individual level issues, i.e., women lacking confidence and women opting out, detracts from the work that must be done at the organizational level in order to dismantle the system of pervasive, structural disadvantage facing women seeking to advance to senior leadership positions.

Advanced paratransit system : an application of digital map, automated vehicle scheduling and vehicle location systems

DOT National Transportation Integrated Search

1997-05-01

This report documents and evaluates an advanced Paratransit system demonstration project. The Santa Clara Valley Transportation Agency (SCVTA), via OUTREACH, implemented such a system, comprised of an automated trip scheduling system (ATSS) and autom...

A next generation advanced traveler information precursor system (ATIS 2.0 precursor system) concept of operations.

DOT National Transportation Integrated Search

2016-10-27

Advanced Traveler Information Systems (ATIS) have experienced significant growth since its initial inception in the 1990s. Technologies have continued to evolve at a rapid pace, enabling the integration of advanced solutions for traveler information ...

A next generation advanced traveler information precursor system (ATIS 2.0 precursor system) use cases report.

DOT National Transportation Integrated Search

2017-05-01

Advanced Traveler Information Systems (ATIS) have experienced significant growth since their initial inception in the 1990s. Technologies have continued to evolve at a rapid pace, enabling the integration of advanced solutions for traveler informatio...

Advanced power system protection and incipient fault detection and protection of spaceborne power systems

NASA Technical Reports Server (NTRS)

Russell, B. Don

1989-01-01

This research concentrated on the application of advanced signal processing, expert system, and digital technologies for the detection and control of low grade, incipient faults on spaceborne power systems. The researchers have considerable experience in the application of advanced digital technologies and the protection of terrestrial power systems. This experience was used in the current contracts to develop new approaches for protecting the electrical distribution system in spaceborne applications. The project was divided into three distinct areas: (1) investigate the applicability of fault detection algorithms developed for terrestrial power systems to the detection of faults in spaceborne systems; (2) investigate the digital hardware and architectures required to monitor and control spaceborne power systems with full capability to implement new detection and diagnostic algorithms; and (3) develop a real-time expert operating system for implementing diagnostic and protection algorithms. Significant progress has been made in each of the above areas. Several terrestrial fault detection algorithms were modified to better adapt to spaceborne power system environments. Several digital architectures were developed and evaluated in light of the fault detection algorithms.

Evaluation Of The Advanced Operating System Of The Ann Arbor Transportation Authority : Driver And Dispatcher Perceptions Of AATA'S Advanced Operating System

DOT National Transportation Integrated Search

1999-01-01

In 1997, the Ann Arbor (Michigan) Transportation Authority began deploying advanced public transportation systems (APTS) technologies in its fixed route and paratransit operations. The project's concept is the integration of a range of such technolog...

Sensor system for buried waste containment sites

DOEpatents

Smith, Ann Marie; Gardner, Bradley M.; Kostelnik, Kevin M.; Partin, Judy K.; Lancaster, Gregory D.; Pfeifer, May Catherine

2000-01-01

A sensor system is disclosed for a buried waste containment site having a bottom wall barrier and/or sidewall barriers, for containing hazardous waste. The sensor system includes one or more sensor devices disposed in one or more of the barriers for detecting a physical parameter either of the barrier itself or of the physical condition of the surrounding soils and buried waste, and for producing a signal representing the physical parameter detected. Also included is a signal processor for receiving signals produced by the sensor device and for developing information identifying the physical parameter detected, either for sounding an alarm, displaying a graphic representation of a physical parameter detected on a viewing screen and/or a hard copy printout. The sensor devices may be deployed in or adjacent the barriers at the same time the barriers are deployed and may be adapted to detect strain or cracking in the barriers, leakage of radiation through the barriers, the presence and leaking through the barriers of volatile organic compounds, or similar physical conditions.

The Design and Testing of the LSSIF Advanced Thermal Control System

NASA Technical Reports Server (NTRS)

Henson, Robert A.; Keller, John R.

1995-01-01

The Life Support Systems Integration Facility (LSSIF) provides a platform to design and evaluate advanced manned space systems at NASA Johnson Space Center (JSC). The LSSIF Early Human Testing Initiative requires the integration of such subsystems to enable human occupancy of the 6 meter chamber for a 90 day closed volume test. The Advanced Thermal Control System (TCS) is an important component of the integrated system by supplying coolant to the subsystems within the chamber, such as the Air Revitalization System. The TCS incorporates an advanced high efficiency, heat pump to reject waste heat from the chamber to an external sink or 'lift' temperature that emulates a Lunar environment. The heat pump is the High Lift Heat Pump, developed by Foster-Miller, Inc., and is the main test article of the TCS. The heat pump prototype utilizes a non-CFC refrigerant in a design where the thermal requirements exceed existing terrestrial technology. These operating requirements provide a unique opportunity to design and test an advanced integrated thermal system and the associated controls. The design, control, and systems integration of the heat pump and the TCS also have terrestrial technology application. This paper addresses the design of the TCS and the heat pump, along with the control scheme to fully test the heat pump. Design approaches utilized in the LSSIF TCS are promoted for implementation in terrestrial thermal systems. The results of the preliminary thermal and fluid analyses used to develop the control of the thermal systems will also be discussed. The paper includes objectives for the 90 day human test and the test setup. Finally, conclusions will be drawn and recommendations for Earth design application are submitted.

One-man, self-contained CO2 concentrating system

NASA Technical Reports Server (NTRS)

Wynveen, R. A.; Schubert, F. H.; Powell, J. D.

1972-01-01

A program to design, fabricate, and test a 1-man, self-contained, electrochemical CO2 concentrating system is described. The system was designed with electronic controls and instrumentation to regulate performance, to analyze and display performance trends, and to detect and isolate faults. Ground support accessories were included to provide power, fluids, and a Parametric Data Display allowing real time indication of operating status in engineering units.

Positive solutions of advanced differential systems.

PubMed

Diblík, Josef; Kúdelčíková, Mária

2013-01-01

We study asymptotic behavior of solutions of general advanced differential systems y(t) = F(t, y(t)), where F : Ω → [Symbol: see text] (n) is a continuous quasi-bounded functional which satisfies a local Lipschitz condition with respect to the second argument and Ω is a subset in [Symbol: see text] × C(r)(n), C(r)(n) := C([0, r], [Symbol: see text] (n)), y t [Symbol: see text]C(r)(n), and y t (θ) = y(t + θ), θ [Symbol: see text] [0, r]. A monotone iterative method is proposed to prove the existence of a solution defined for t → ∞ with the graph coordinates lying between graph coordinates of two (lower and upper) auxiliary vector functions. This result is applied to scalar advanced linear differential equations. Criteria of existence of positive solutions are given and their asymptotic behavior is discussed.

Freight Advanced Traveler Information System (FRATIS) impact assessment.

DOT National Transportation Integrated Search

2016-01-01

This report is an independent assessment of three prototype Freight Advanced Traveler Information System (FRATIS) tests at Los Angeles, Dallas/Fort Worth, and South Florida. The FRATIS technologies deployed at one or two drayage companies in each tes...

Meta-expert system for cargo container screening

NASA Astrophysics Data System (ADS)

Alberts, David S.

1994-02-01

This paper reports upon improvements and extensions of rule-based expert systems and related technologies in the context of their application to the cargo container screening problem. These innovations have been incorporated into a system built for and deployed by U.S. Customs with funding provided by the DCI's Counter Narcotics Committee. Given the serious nature of the drug smuggling threat and the low probability of intercept, the ability to target the extremely limited inspectional resources available to U.S. Customs is a prerequisite for success in fighting the `Drug War.'

Concept for a Satellite-Based Advanced Air Traffic Management System : Volume 5. System Performance.

DOT National Transportation Integrated Search

1974-02-01

The volume presents the results of the performance evaluation of the Satellite-Based Advanced Air Traffic Management System (SAATMS). The evaluation established the capacity, safety, and delay performance of the system for the Los Angeles Basin termi...

Advanced Technologies and Methodology for Automated Ultrasonic Testing Systems Quantification

DOT National Transportation Integrated Search

2011-04-29

For automated ultrasonic testing (AUT) detection and sizing accuracy, this program developed a methodology for quantification of AUT systems, advancing and quantifying AUT systems imagecapture capabilities, quantifying the performance of multiple AUT...

The three-dimensional Multi-Block Advanced Grid Generation System (3DMAGGS)

NASA Technical Reports Server (NTRS)

Alter, Stephen J.; Weilmuenster, Kenneth J.

1993-01-01

As the size and complexity of three dimensional volume grids increases, there is a growing need for fast and efficient 3D volumetric elliptic grid solvers. Present day solvers are limited by computational speed and do not have all the capabilities such as interior volume grid clustering control, viscous grid clustering at the wall of a configuration, truncation error limiters, and convergence optimization residing in one code. A new volume grid generator, 3DMAGGS (Three-Dimensional Multi-Block Advanced Grid Generation System), which is based on the 3DGRAPE code, has evolved to meet these needs. This is a manual for the usage of 3DMAGGS and contains five sections, including the motivations and usage, a GRIDGEN interface, a grid quality analysis tool, a sample case for verifying correct operation of the code, and a comparison to both 3DGRAPE and GRIDGEN3D. Since it was derived from 3DGRAPE, this technical memorandum should be used in conjunction with the 3DGRAPE manual (NASA TM-102224).

Advanced payload concepts and system architecture for emerging services in Indian National Satellite Systems

NASA Astrophysics Data System (ADS)

Balasubramanian, E. P.; Rao, N. Prahlad; Sarkar, S.; Singh, D. K.

2008-07-01

Over the past two decades Indian Space Research Organization (ISRO) has developed and operationalized satellites to generate a large capacity of transponders for telecommunication service use in INSAT system. More powerful on-board transmitters are built to usher-in direct-to-home broadcast services. These have transformed the Satcom application scenario in the country. With the proliferation of satellite technology, a shift in the Indian market is witnessed today in terms of demand for new services like Broadband Internet, Interactive Multimedia, etc. While it is imperative to pay attention to market trends, ISRO is also committed towards taking the benefits of technological advancement to all round growth of our population, 70% of which dwell in rural areas. The initiatives already taken in space application related to telemedicine, tele-education and Village Resource Centres are required to be taken to a greater height of efficiency. These targets pose technological challenges to build a large capacity and cost-effective satellite system. This paper addresses advanced payload concepts and system architecture along with the trade-off analysis on design parameters in proposing a new generation satellite system capable of extending the reach of the Indian broadband structure to individual users, educational and medical institutions and enterprises for interactive services. This will be a strategic step in the evolution of INSAT system to employ advanced technology to touch every human face of our population.

Develop Advanced Nonlinear Signal Analysis Topographical Mapping System

NASA Technical Reports Server (NTRS)

Jong, Jen-Yi

1997-01-01

During the development of the SSME, a hierarchy of advanced signal analysis techniques for mechanical signature analysis has been developed by NASA and AI Signal Research Inc. (ASRI) to improve the safety and reliability for Space Shuttle operations. These techniques can process and identify intelligent information hidden in a measured signal which is often unidentifiable using conventional signal analysis methods. Currently, due to the highly interactive processing requirements and the volume of dynamic data involved, detailed diagnostic analysis is being performed manually which requires immense man-hours with extensive human interface. To overcome this manual process, NASA implemented this program to develop an Advanced nonlinear signal Analysis Topographical Mapping System (ATMS) to provide automatic/unsupervised engine diagnostic capabilities. The ATMS will utilize a rule-based Clips expert system to supervise a hierarchy of diagnostic signature analysis techniques in the Advanced Signal Analysis Library (ASAL). ASAL will perform automatic signal processing, archiving, and anomaly detection/identification tasks in order to provide an intelligent and fully automated engine diagnostic capability. The ATMS has been successfully developed under this contract. In summary, the program objectives to design, develop, test and conduct performance evaluation for an automated engine diagnostic system have been successfully achieved. Software implementation of the entire ATMS system on MSFC's OISPS computer has been completed. The significance of the ATMS developed under this program is attributed to the fully automated coherence analysis capability for anomaly detection and identification which can greatly enhance the power and reliability of engine diagnostic evaluation. The results have demonstrated that ATMS can significantly save time and man-hours in performing engine test/flight data analysis and performance evaluation of large volumes of dynamic test data.

Advanced rural transportation systems (ARTS) : rural intelligent transportation systems (ITS) : program plan

DOT National Transportation Integrated Search

1996-08-01

This Program Plan for the Advanced Rural Transportation Systems (ARTS) implements the goals and objectives established in the U.S. Department of Transportations (USDOTs) Strategic Plan for the ARTS. This Program Plan proposes five years (FY 97...

An Advanced Buffet Load Alleviation System

NASA Technical Reports Server (NTRS)

Burnham, Jay K.; Pitt, Dale M.; White, Edward V.; Henderson, Douglas A.; Moses, Robert W.

2001-01-01

This paper describes the development of an advanced buffet load alleviation (BLA) system that utilizes distributed piezoelectric actuators in conjunction with an active rudder to reduce the structural dynamic response of the F/A-18 aircraft vertical tails to buffet loads. The BLA system was defined analytically with a detailed finite-element-model of the tail structure and piezoelectric actuators. Oscillatory aerodynamics were included along with a buffet forcing function to complete the aeroservoelastic model of the tail with rudder control surface. Two single-input-single-output (SISO) controllers were designed, one for the active rudder and one for the active piezoelectric actuators. The results from the analytical open and closed loop simulations were used to predict the system performance. The objective of this BLA system is to extend the life of vertical tail structures and decrease their life-cycle costs. This system can be applied to other aircraft designs to address suppression of structural vibrations on military and commercial aircraft.

Advanced data management system architectures testbed

NASA Technical Reports Server (NTRS)

Grant, Terry

1990-01-01

The objective of the Architecture and Tools Testbed is to provide a working, experimental focus to the evolving automation applications for the Space Station Freedom data management system. Emphasis is on defining and refining real-world applications including the following: the validation of user needs; understanding system requirements and capabilities; and extending capabilities. The approach is to provide an open, distributed system of high performance workstations representing both the standard data processors and networks and advanced RISC-based processors and multiprocessor systems. The system provides a base from which to develop and evaluate new performance and risk management concepts and for sharing the results. Participants are given a common view of requirements and capability via: remote login to the testbed; standard, natural user interfaces to simulations and emulations; special attention to user manuals for all software tools; and E-mail communication. The testbed elements which instantiate the approach are briefly described including the workstations, the software simulation and monitoring tools, and performance and fault tolerance experiments.

Cost estimating methods for advanced space systems

NASA Technical Reports Server (NTRS)

Cyr, Kelley

1988-01-01

The development of parametric cost estimating methods for advanced space systems in the conceptual design phase is discussed. The process of identifying variables which drive cost and the relationship between weight and cost are discussed. A theoretical model of cost is developed and tested using a historical data base of research and development projects.

Regolith Advanced Surface Systems Operations Robot Excavator

NASA Technical Reports Server (NTRS)

Mueller, Robert P.; Smith, Jonathan D.; Ebert, Thomas; Cox, Rachel; Rahmatian, Laila; Wood, James; Schuler, Jason; Nick, Andrew

2013-01-01

The Regolith Advanced Surface Systems Operations Robot (RASSOR) excavator robot is a teleoperated mobility platform with a space regolith excavation capability. This more compact, lightweight design (<50 kg) has counterrotating bucket drums, which results in a net-zero reaction horizontal force due to the self-cancellation of the symmetrical, equal but opposing, digging forces.

Design and Experimental Evaluation on an Advanced Multisource Energy Harvesting System for Wireless Sensor Nodes

PubMed Central

Li, Hao; Zhang, Gaofei; Ma, Rui; You, Zheng

2014-01-01

An effective multisource energy harvesting system is presented as power supply for wireless sensor nodes (WSNs). The advanced system contains not only an expandable power management module including control of the charging and discharging process of the lithium polymer battery but also an energy harvesting system using the maximum power point tracking (MPPT) circuit with analog driving scheme for the collection of both solar and vibration energy sources. Since the MPPT and the power management module are utilized, the system is able to effectively achieve a low power consumption. Furthermore, a super capacitor is integrated in the system so that current fluctuations of the lithium polymer battery during the charging and discharging processes can be properly reduced. In addition, through a simple analog switch circuit with low power consumption, the proposed system can successfully switch the power supply path according to the ambient energy sources and load power automatically. A practical WSNs platform shows that efficiency of the energy harvesting system can reach about 75–85% through the 24-hour environmental test, which confirms that the proposed system can be used as a long-term continuous power supply for WSNs. PMID:25032233

Design and experimental evaluation on an advanced multisource energy harvesting system for wireless sensor nodes.

PubMed

Li, Hao; Zhang, Gaofei; Ma, Rui; You, Zheng

2014-01-01

An effective multisource energy harvesting system is presented as power supply for wireless sensor nodes (WSNs). The advanced system contains not only an expandable power management module including control of the charging and discharging process of the lithium polymer battery but also an energy harvesting system using the maximum power point tracking (MPPT) circuit with analog driving scheme for the collection of both solar and vibration energy sources. Since the MPPT and the power management module are utilized, the system is able to effectively achieve a low power consumption. Furthermore, a super capacitor is integrated in the system so that current fluctuations of the lithium polymer battery during the charging and discharging processes can be properly reduced. In addition, through a simple analog switch circuit with low power consumption, the proposed system can successfully switch the power supply path according to the ambient energy sources and load power automatically. A practical WSNs platform shows that efficiency of the energy harvesting system can reach about 75-85% through the 24-hour environmental test, which confirms that the proposed system can be used as a long-term continuous power supply for WSNs.

Advanced extravehicular activity systems requirements definition study

NASA Technical Reports Server (NTRS)

1988-01-01

A study to define the requirements for advanced extravehicular activities (AEVA) was conducted. The purpose of the study was to develop an understanding of the EVA technology requirements and to map a pathway from existing or developing technologies to an AEVA system capable of supporting long-duration missions on the lunar surface. The parameters of an AEVA system which must sustain the crewmembers and permit productive work for long periods in the lunar environment were examined. A design reference mission (DRM) was formulated and used as a tool to develop and analyze the EVA systems technology aspects. Many operational and infrastructure design issues which have a significant influence on the EVA system are identified.

An advanced domestic satellite communications system

NASA Technical Reports Server (NTRS)

1980-01-01

An updated traffic projection for U.S. domestic satellite communications service covering a period of 15 years; mid-1980 to mid-1995 was prepared. This model takes into account expected technology advances and reductions in transmission costs, legislative and regulatory changes permitting increased competition, and rising energy costs which will encourage more extensive substitution of telecommunications for travel. The historical development and current status of satellite systems are discussed as well as the characteristics of follow-on systems. Orbital arc utilization, spacecraft configuration for single shuttle launch, Earth station configuration, and system costs are examined. Areas which require technology development include multiple beam frequency reuse antennas, on-board switching, intersatellite links, and ka-band operation. Packing and deployment schemes for enclosing the satellite within the shuttle orbiter bay must also be devised.

Hollow fiber membrane systems for advanced life support systems

NASA Technical Reports Server (NTRS)

Roebelen, G. J., Jr.; Lysaght, M. J.

1976-01-01

The practicability of utilizing hollow fiber membranes in vehicular and portable life support system applications is described. A preliminary screening of potential advanced life support applications resulted in the selection of five applications for feasibility study and testing. As a result of the feasibility study and testing, three applications, heat rejection, deaeration, and bacteria filtration, were chosen for breadboard development testing; breadboard hardware was manufactured and tested, and the physical properties of the hollow fiber membrane assemblies are characterized.

Advanced power systems for EOS

NASA Technical Reports Server (NTRS)

Bailey, Sheila G.; Weinberg, Irving; Flood, Dennis J.

1991-01-01

The Earth Observing System, which is part of the International Mission to Planet Earth, is NASA's main contribution to the Global Change Research Program. Five large platforms are to be launched into polar orbit: two by NASA, two by the European Space Agency, and one by the Japanese. In such an orbit the radiation resistance of indium phosphide solar cells combined with the potential of utilizing 5 micron cell structures yields an increase of 10 percent in the payload capability. If further combined with the Advanced Photovoltaic Solar Array, the total additional payload capability approaches 12 percent.

Concept for a Satellite-Based Advanced Air Traffic Management System : Volume 7. System Cost.

DOT National Transportation Integrated Search

1973-02-01

The volume presents estimates of the federal government and user costs for the Satellite-Based Advanced Air Traffic Management System and the supporting rationale. The system configuration is that presented in volumes II and III. The cost estimates a...

Public Health Surveillance Systems: Recent Advances in Their Use and Evaluation.

PubMed

Groseclose, Samuel L; Buckeridge, David L

2017-03-20

Surveillance is critical for improving population health. Public health surveillance systems generate information that drives action, and the data must be of sufficient quality and with a resolution and timeliness that matches objectives. In the context of scientific advances in public health surveillance, changing health care and public health environments, and rapidly evolving technologies, the aim of this article is to review public health surveillance systems. We consider their current use to increase the efficiency and effectiveness of the public health system, the role of system stakeholders, the analysis and interpretation of surveillance data, approaches to system monitoring and evaluation, and opportunities for future advances in terms of increased scientific rigor, outcomes-focused research, and health informatics.

Spacecraft applications of advanced global positioning system technology

NASA Technical Reports Server (NTRS)

1988-01-01

This is the final report on the Texas Instruments Incorporated (TI) simulations study of Spacecraft Application of Advanced Global Positioning System (GPS) Technology. This work was conducted for the NASA Johnson Space Center (JSC) under contract NAS9-17781. GPS, in addition to its baselined capability as a highly accurate spacecraft navigation system, can provide traffic control, attitude control, structural control, and uniform time base. In Phase 1 of this program, another contractor investigated the potential of GPS in these four areas and compared GPS to other techniques. This contract was for the Phase 2 effort, to study the performance of GPS for these spacecraft applications through computer simulations. TI had previously developed simulation programs for GPS differential navigation and attitude measurement. These programs were adapted for these specific spacecraft applications. In addition, TI has extensive expertise in the design and production of advanced GPS receivers, including space-qualified GPS receivers. We have drawn on this background to augment the simulation results in the system level overview, which is Section 2 of this report.

The potential benefit of an advanced integrated utility system

NASA Technical Reports Server (NTRS)

Wolfer, B. M.

1975-01-01

The applicability of an advanced integrated utility system based on 1980 technology was investigated. An example of such a system, which provides electricity, heating and air conditioning, solid waste disposal, and water treatment in a single integrated plant, is illustrated for a hypothetical apartment complex. The system requires approximately 50 percent of the energy and approximately 55 percent of the water that would be required by a typical current conventional system.

Considering Intermittent Dormancy in an Advanced Life Support Systems Architecture

NASA Technical Reports Server (NTRS)

Sargusingh, Miriam J.; Perry, Jay L.

2017-01-01

Many advanced human space exploration missions being considered by the National Aeronautics and Space Administration (NASA) include concepts in which in-space systems cycle between inhabited and uninhabited states. Managing the life support system (LSS) may be particularly challenged during these periods of intermittent dormancy. A study to identify LSS management challenges and considerations relating to dormancy is described. The study seeks to define concepts suitable for addressing intermittent dormancy states and to evaluate whether the reference LSS architectures being considered by the Advanced Exploration Systems (AES) Life Support Systems Project (LSSP) are sufficient to support this operational state. The primary focus of the study is the mission concept considered to be the most challenging-a crewed Mars mission with an extensive surface stay. Results from this study are presented and discussed.

Space Launch System Advanced Development Office, FY 2013 Annual Report

NASA Technical Reports Server (NTRS)

Crumbly, C. M.; Bickley, F. P.; Hueter, U.

2013-01-01

The Advanced Development Office (ADO), part of the Space Launch System (SLS) program, provides SLS with the advanced development needed to evolve the vehicle from an initial Block 1 payload capability of 70 metric tons (t) to an eventual capability Block 2 of 130 t, with intermediary evolution options possible. ADO takes existing technologies and matures them to the point that insertion into the mainline program minimizes risk. The ADO portfolio of tasks covers a broad range of technical developmental activities. The ADO portfolio supports the development of advanced boosters, upper stages, and other advanced development activities benefiting the SLS program. A total of 34 separate tasks were funded by ADO in FY 2013.

The Evaluation and Implementation of a Water Containment System to Support Aerospace Flywheel Testing

NASA Technical Reports Server (NTRS)

Trase, Larry M.

2002-01-01

High-energy flywheel systems for aerospace power storage and attitude control applications are being developed because of the potential for increasing the energy density and reducing operational costs. A significant challenge facing the development of the test hardware is containment of the rotating elements in the event of a failure during the development and qualification stages of testing. This containment is critical in order to ensure the safety of the test personnel and the facility. A containment system utilizing water as the containment media is presented. Water containment was found to be a low cost, flexible, and highly effective containment system. Ballistic test results and analytical results are discussed along with a description of a flywheel test facility that was designed and built utilizing the water containment system at the NASA Glenn Research Center at Lewis Field in Cleveland, Ohio.

Graphite/Polyimide Composites. [conference on Composites for Advanced Space Transportation Systems

NASA Technical Reports Server (NTRS)

Dexter, H. B. (Editor); Davis, J. G., Jr. (Editor)

1979-01-01

Technology developed under the Composites for Advanced Space Transportation System Project is reported. Specific topics covered include fabrication, adhesives, test methods, structural integrity, design and analysis, advanced technology developments, high temperature polymer research, and the state of the art of graphite/polyimide composites.

Advanced telemetry systems for payloads. Technology needs, objectives and issues

NASA Technical Reports Server (NTRS)

1990-01-01

The current trends in advanced payload telemetry are the new developments in advanced modulation/coding, the applications of intelligent techniques, data distribution processing, and advanced signal processing methodologies. Concerted efforts will be required to design ultra-reliable man-rated software to cope with these applications. The intelligence embedded and distributed throughout various segments of the telemetry system will need to be overridden by an operator in case of life-threatening situations, making it a real-time integration issue. Suitable MIL standards on physical interfaces and protocols will be adopted to suit the payload telemetry system. New technologies and techniques will be developed for fast retrieval of mass data. Currently, these technology issues are being addressed to provide more efficient, reliable, and reconfigurable systems. There is a need, however, to change the operation culture. The current role of NASA as a leader in developing all the new innovative hardware should be altered to save both time and money. We should use all the available hardware/software developed by the industry and use the existing standards rather than inventing our own.

Low Leakage Turbine Shaft Seals for Advanced Combined Cycle Systems.

DTIC Science & Technology

1984-11-01

Both used feedwater -supplied buffer water as required by advanced combined cycle steam turbomachinery. It was shown to be advantageous, at least from...RD-fi149 372 LOW LEAKAGE’TURBINE SHAFT SEALS FOR ADVANCED COMBINED 1/2- CYCLE SYSTEMS(U) SOLAR TURBINES INC SAN DIEGO CA G W HOSANG NOV 84 SR84-R...4622-36 N88824-7B-C-5345 UNCLASSIFIED F/1 i/i NL AIONA L RUEA OF B 20NADS16 Final Report N 4 <Low Leakage Turbine Shaft Seals for Advanced Combined Cycle

An overview of recent advances in system identification

NASA Technical Reports Server (NTRS)

Juang, Jer-Nan

1994-01-01

This paper presents an overview of the recent advances in system identification for modal testing and control of large flexible structures. Several techniques are discussed including the Observer/Kalman Filter Identification, the Observer/Controller Identification, and the State-Space System Identification in the Frequency Domain. The System/Observer/Controller Toolbox developed at NASA Langley Research Center is used to show the applications of these techniques to real aerospace structures such as the Hubble spacecraft telescope and the active flexible aircraft wing.

Advanced vehicle systems assessment. Volume 4: Supporting analyses

NASA Technical Reports Server (NTRS)

Hardy, K.

1985-01-01

Volume 4 (Supporting Analyses) is part of a five-volume report, Advanced Vehicle Systems Assessment. Thirty-nine individuals, knowledgeable in advanced technology, were interviewed to obtain their preferences. Rankings were calculated for the eight groups they represented, using multiplicative and additive utility models. The four topics for consideration were: (1) preferred range for various battery technologies; (2) preferred battery technology for each of a variety of travel ranges; (3) most promising battery technology, vehicle range combination; and (4) comparison of the most preferred electric vehicle with the methanol-fuled, spark-ignition engine vehicle and with the most preferred of the hybrid vehicles.

X-ray cargo container inspection system with few-view projection imaging

NASA Astrophysics Data System (ADS)

Duan, Xinhui; Cheng, Jianping; Zhang, Li; Xing, Yuxiang; Chen, Zhiqiang; Zhao, Ziran

2009-01-01

An X-ray cargo inspection system with few-view projection imaging is developed for detecting contraband in air containers. This paper describes this developing inspection system, including its configuration and the process of inspection using three imaging modalities: digital radiography (DR), few view imaging and computed tomography (CT). The few-view imaging can provide 3D images with much faster scanning speed than CT and do great help to quickly locate suspicious cargo in a container. An algorithm to reconstruct tomographic images from severely sparse projection data of few-view imaging is discussed. A cooperative work manner of the three modalities is presented to make the inspection more convenient and effective. Numerous experiments of performance tests and modality comparison are performed on our system for inspecting air containers. Results demonstrate the effectiveness of our methods and implementation of few-view imaging in practical inspection systems.

Identification of salt-alloy combinations for thermal energy storage applications in advanced solar dynamic power systems

NASA Technical Reports Server (NTRS)

Whittenberger, J. D.; Misra, A. K.

1987-01-01

Thermodynamic calculations based on the available data for flouride salt systems reveal that a number of congruently melting compositions and eutectics exist which have the potential to meet the lightweight, high energy storage requirements imposed for advanced solar dynamic systems operating between about 1000 and 1400 K. Compatibility studies to determine suitable containment alloys to be used with NaF-22CaF2-13MgF2, NaF-32CaF2, and NaF-23MgF2 have been conducted at the eutectic temperature + 25 K for each system. For these three NaF-based eutectics, none of the common, commercially available high temperature alloys appear to offer adequate corrosion resistance for a long lifetime; however mild steel, pure nickel and Nb-1Zr could prove useful. These latter materials suggest the possibility that a strong, corrosion resistant, nonrefractory, elevated temperature alloy based on the Ni-Ni3Nb system could be developed.

Concept for a Satellite-Based Advanced Air Traffic Management System : Volume 8. Operational Logic Flow Diagrams for a Generic Advanced Air Traffic Management system

DOT National Transportation Integrated Search

1974-02-01

The volume presents a description of the services a generic Advanced Air Traffic Management System (AATMS) should provide to the useres of the system to facilitate the safe, efficient flow of traffic. It provides a definition of the functions which t...

Advanced electrical power system technology for the all electric aircraft

NASA Technical Reports Server (NTRS)

Finke, R. C.; Sundberg, G. R.

1983-01-01

The application of advanced electric power system technology to an all electric airplane results in an estimated reduction of the total takeoff gross weight of over 23,000 pounds for a large airplane. This will result in a 5 to 10 percent reduction in direct operating costs (DOC). Critical to this savings is the basic electrical power system component technology. These advanced electrical power components will provide a solid foundation for the materials, devices, circuits, and subsystems needed to satisfy the unique requirements of advanced all electric aircraft power systems. The program for the development of advanced electrical power component technology is described. The program is divided into five generic areas: semiconductor devices (transistors, thyristors, and diodes); conductors (materials and transmission lines); dielectrics; magnetic devices; and load management devices. Examples of progress in each of the five areas are discussed. Bipolar power transistors up to 1000 V at 100 A with a gain of 10 and a 0.5 microsec rise and fall time are presented. A class of semiconductor devices with a possibility of switching up to 100 kV is described. Solid state power controllers for load management at 120 to 1000 V and power levels to 25 kW were developed along with a 25 kW, 20 kHz transformer weighing only 3.2 kg.

Advanced electrical power system technology for the all electric aircraft

NASA Technical Reports Server (NTRS)

Finke, R. C.; Sundberg, G. R.

1983-01-01

The application of advanced electric power system technology to an all electric airplane results in an estimated reduction of the total takeoff gross weight of over 23,000 pounds for a large airplane. This will result in a 5 to 10 percent reduction in direct operating costs (DOC). Critical to this savings is the basic electrical power system component technology. These advanced electrical power components will provide a solid foundation for the materials, devices, circuits, and subsystems needed to satisfy the unique requirements of advanced all electric aircraft power systems. The program for the development of advanced electrical power component technology is described. The program is divided into five generic areas: semiconductor devices (transistors, thyristors, and diodes); conductors (materials and transmission lines); dielectrics; magnetic devices; and load management devices. Examples of progress in each of the five areas are discussed. Bipolar power transistors up to 1000 V at 100 A with a gain of 10 and a 0.5 microsec rise and fall time are presented. A class of semiconductor devices with a possibility of switching up to 100 kV is described. Solid state power controllers for load management at 120 to 1000 V and power levels to 25 kW were developed along with a 25 kW, 20 kHz transformer weighing only 3.2 kg. Previously announced in STAR as N83-24764

Evaluation Plan for the Cape Cod Advanced Public Transportation System

DOT National Transportation Integrated Search

2000-06-01

The Cape Cod Regional Transit Authority (CCRTA) Advanced Public Transportation System (APTS) project is an application of Intelligent Transportation Systems (ITS) to fixed route and paratransit operations in a rural transit setting. The purpose of th...

Advanced public transportation systems deployment in the United States : year 2002 update

DOT National Transportation Integrated Search

2003-06-01

This report documents work performed under the Federal Transit Administration's Advanced Public Transportation Systems (APTS) Program, a program structured to undertake research and development of innovative applications of advanced navigation, infor...

Advanced public transportation systems deployment in the United States : year 2000 update

DOT National Transportation Integrated Search

2002-05-01

This report documents work performed under the Federal Transit Administration's Advanced Public Transportation Systems (APTS) Program, a program structured to undertake research and development of innovative applications of advanced navigation, infor...

Advanced public transportation systems deployment in the United States : year 2004 update

DOT National Transportation Integrated Search

2005-06-01

This report documents work performed under the Federal Transit Administration's Advanced Public Transportation Systems (APTS) Program, a program structured to undertake research and development of innovative applications of advanced navigation, infor...

Advanced public transportation systems : the state of the art update of 1998

DOT National Transportation Integrated Search

1998-01-01

This report documents work performed under FTA's Advanced Public Transportation Systems (APTS) Program, a program structured to undertake research and development of innovative applications of advanced navigation, information, computer, and communica...

Advanced Public Transportation Systems Deployment in the United States, Year 2000, Update

DOT National Transportation Integrated Search

2002-05-01

This report documents work performed under the Federal Transit Administration's Advanced Public Transportation Systems (APTS) Program, a program structured to undertake research and development of innovative applications of advanced navigation, infor...

Advanced Public Transportation Systems Deployment in the United States. Update, January 1999

DOT National Transportation Integrated Search

1999-01-01

This report documents work performed under FTA's Advanced Public Transportation Systems (APTS) Program, a program structured to undertake research and development of innovative applications of advanced navigation, information, and communication techn...

Advanced public transportation systems deployment in the United States : update, January 1999

DOT National Transportation Integrated Search

1999-01-01

This report documents work performed under FTA's Advanced Public Transportation Systems (APTS) Program, a program structured to undertake research and development of innovative applications of advances navigation, information, and communication techn...

Advanced integrated enhanced vision systems

NASA Astrophysics Data System (ADS)

Kerr, J. R.; Luk, Chiu H.; Hammerstrom, Dan; Pavel, Misha

2003-09-01

In anticipation of its ultimate role in transport, business and rotary wing aircraft, we clarify the role of Enhanced Vision Systems (EVS): how the output data will be utilized, appropriate architecture for total avionics integration, pilot and control interfaces, and operational utilization. Ground-map (database) correlation is critical, and we suggest that "synthetic vision" is simply a subset of the monitor/guidance interface issue. The core of integrated EVS is its sensor processor. In order to approximate optimal, Bayesian multi-sensor fusion and ground correlation functionality in real time, we are developing a neural net approach utilizing human visual pathway and self-organizing, associative-engine processing. In addition to EVS/SVS imagery, outputs will include sensor-based navigation and attitude signals as well as hazard detection. A system architecture is described, encompassing an all-weather sensor suite; advanced processing technology; intertial, GPS and other avionics inputs; and pilot and machine interfaces. Issues of total-system accuracy and integrity are addressed, as well as flight operational aspects relating to both civil certification and military applications in IMC.

First-in-Human Phase 1 Trial of Agarose Beads Containing Murine RENCA Cells in Advanced Solid Tumors.

PubMed

Smith, Barry H; Parikh, Tapan; Andrada, Zoe P; Fahey, Thomas J; Berman, Nathaniel; Wiles, Madeline; Nazarian, Angelica; Thomas, Joanne; Arreglado, Anna; Akahoho, Eugene; Wolf, David J; Levine, Daniel M; Parker, Thomas S; Gazda, Lawrence S; Ocean, Allyson J

2016-01-01

Agarose macrobeads containing mouse renal adenocarcinoma cells (RMBs) release factors, suppressing the growth of cancer cells and prolonging survival in spontaneous or induced tumor animals, mediated, in part, by increased levels of myocyte-enhancing factor (MEF2D) via EGFR-and AKT-signaling pathways. The primary objective of this study was to determine the safety of RMBs in advanced, treatment-resistant metastatic cancers, and then its efficacy (survival), which is the secondary objective. Thirty-one patients underwent up to four intraperitoneal implantations of RMBs (8 or 16 macrobeads/kg) via laparoscopy in this single-arm trial (FDA BB-IND 10091; NCT 00283075). Serial physical examinations, laboratory testing, and PET-CT imaging were performed before and three months after each implant. RMBs were well tolerated at both dose levels (mean 660.9 per implant). AEs were (Grade 1/2) with no treatment-related SAEs. The data support the safety of RMB therapy in advanced-malignancy patients, and the preliminary evidence for their potential efficacy is encouraging. A Phase 2 efficacy trial is ongoing.

Hydraulic Shuttle Irradiation System (HSIS) Recently Installed in the Advanced Test Reactor (ATR)

DOE Office of Scientific and Technical Information (OSTI.GOV)

A. Joseph Palmer; Gerry L. McCormick; Shannon J. Corrigan

2010-06-01

2010 International Congress on Advances in Nuclear Power Plants (ICAPP’10) ANS Annual Meeting Imbedded Topical San Diego, CA June 13 – 17, 2010 Hydraulic Shuttle Irradiation System (HSIS) Recently Installed in the Advanced Test Reactor (ATR) Author: A. Joseph Palmer, Mechanical Engineer, Irradiation Test Programs, 208-526-8700, Joe.Palmer@INL.gov Affiliation: Idaho National Laboratory P.O. Box 1625, MS-3840 Idaho Falls, ID 83415 INL/CON-10-17680 ABSTRACT Most test reactors are equipped with shuttle facilities (sometimes called rabbit tubes) whereby small capsules can be inserted into the reactor and retrieved during power operations. With the installation of Hydraulic Shuttle Irradiation System (HSIS) this capability has beenmore » restored to the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL). The general design and operating principles of this system were patterned after the hydraulic rabbit at Oak Ridge National Laboratory’s (ORNL) High Flux Isotope Reactor (HFIR), which has operated successfully for many years. Using primary coolant as the motive medium the HSIS system is designed to simultaneously transport fourteen shuttle capsules, each 16 mm OD x 57 mm long, to and from the B-7 position of the reactor. The B-7 position is one of the higher flux positions in the reactor with typical thermal and fast (>1 Mev) fluxes of 2.8E+14 n/cm2/sec and 1.9E+14 n/cm2/sec respectively. The available space inside each shuttle is approximately 14 mm diameter x 50 mm long. The shuttle containers are made from titanium which was selected for its low neutron activation properties and durability. Shuttles can be irradiated for time periods ranging from a few minutes to several months. The Send and Receive Station (SRS) for the HSIS is located 2.5 m deep in the ATR canal which allows irradiated shuttles to be easily moved from the SRS to a wet loaded cask, or transport pig. The HSIS system first irradiated (empty) shuttles in September 2009 and has since

The Air Force Advanced Instructional System (AIS): An Overview.

ERIC Educational Resources Information Center

Yasutake, Joseph Y.; Stobie, William H.

The Air Force Advanced Instructional System (AIS) is a prototype computer-based multimedia system for the administration and management of individualized technical training on a large scale. The paper provides an overview of the AIS: (1) its purposes and goals, (2) the background and rationale for the development approach, (3) a basic description…

Fish farming in land-based closed-containment systems

USDA-ARS?s Scientific Manuscript database

'An International Summit on Fish Farming in Land-Based Closed-Containment Systems' was hosted by the Conservation Fund's Freshwater Institute, the Gordon and Betty Moore Foundation (GBMF), the Atlantic Salmon Federation (ASF), and Tides Canada (TC) at the National Conservation Training Center in She...

Recent Advances in Aptamers Targeting Immune System.

PubMed

Hu, Piao-Ping

2017-02-01

The immune system plays important role in protecting the organism by recognizing non-self molecules from pathogen such as bacteria, parasitic worms, and viruses. When the balance of the host defense system is disturbed, immunodeficiency, autoimmunity, and inflammation occur. Nucleic acid aptamers are short single-stranded DNA (ssDNA) or RNA ligands that interact with complementary molecules with high specificity and affinity. Aptamers that target the molecules involved in immune system to modulate their function have great potential to be explored as new diagnostic and therapeutic agents for immune disorders. This review summarizes recent advances in the development of aptamers targeting immune system. The selection of aptamers with superior chemical and biological characteristics will facilitate their application in the diagnosis and treatment of immune disorders.

Demonstration Advanced Avionics System (DAAS) function description

NASA Technical Reports Server (NTRS)

Bailey, A. J.; Bailey, D. G.; Gaabo, R. J.; Lahn, T. G.; Larson, J. C.; Peterson, E. M.; Schuck, J. W.; Rodgers, D. L.; Wroblewski, K. A.

1982-01-01

The Demonstration Advanced Avionics System, DAAS, is an integrated avionics system utilizing microprocessor technologies, data busing, and shared displays for demonstrating the potential of these technologies in improving the safety and utility of general aviation operations in the late 1980's and beyond. Major hardware elements of the DAAS include a functionally distributed microcomputer complex, an integrated data control center, an electronic horizontal situation indicator, and a radio adaptor unit. All processing and display resources are interconnected by an IEEE-488 bus in order to enhance the overall system effectiveness, reliability, modularity and maintainability. A detail description of the DAAS architecture, the DAAS hardware, and the DAAS functions is presented. The system is designed for installation and flight test in a NASA Cessna 402-B aircraft.

Concept for a Satellite-Based Advanced Air Traffic Management System : Volume 2. System Functional Description and System Specification.

DOT National Transportation Integrated Search

1973-02-01

The volume provides a functional description and specification for the Satellite-Based Advanced Air Traffic Management System. The system description is presented in terms of the surveillance, navigation, and communications functions along with the a...

Advanced Electronic Systems. Curriculum Guide for Technology Education.

ERIC Educational Resources Information Center

Patrick, Dale R.

This curriculum for a 1-semester or 1-year course in electronics is designed to take students from basic through advanced electronic systems. It covers several electronic areas, such as digital electronics, communication electronics, industrial process control, instrumentation, programmable controllers, and robotics. The guide contains…

Development of Metal Matrix Composites for NASA'S Advanced Propulsion Systems

NASA Technical Reports Server (NTRS)

Lee, Jonathan A.

2000-01-01

The state-of-the-art development of several aluminum and copper based Metal Matrix Composites (MMC) for NASA's advanced propulsion systems will be presented. The presentation's goal is to provide an overview of NASA-Marshall Space Flight Center's planned and on-going activities in MMC for advanced liquid rocket engines such as the X-33 vehicle's Aerospike and X-34 Fastrac engine. The focus will be on lightweight and environmental compatibility with oxygen and hydrogen of key MMC materials, within each NASA's new propulsion application, that will provide a high payoff for NASA's reusable launch vehicle systems and space access vehicles. Advanced MMC processing techniques such as plasma spray, centrifugal casting, pressure infiltration casting will be discussed. Development of a novel 3D printing method for low cost production of composite preform, and functional gradient MMC to enhanced rocket engine's dimensional stability will be presented.

Advanced Manned Launch System (AMLS) study

NASA Technical Reports Server (NTRS)

Ehrlich, Carl F., Jr.; Potts, Jack; Brown, Jerry; Schell, Ken; Manley, Mary; Chen, Irving; Earhart, Richard; Urrutia, Chuck; Randolph, Ray; Morris, Jim

1992-01-01

To assure national leadership in space operations and exploration in the future, NASA must be able to provide cost effective and operationally efficient space transportation. Several NASA studies and the joint NASA/DoD Space Transportation Architecture Studies (STAS) have shown the need for a multi-vehicle space transportation system with designs driven by enhanced operations and low costs. NASA is currently studying an advanced manned launch system (AMLS) approach to transport crew and cargo to the Space Station Freedom. Several single and multiple stage systems from air-breathing to all-rocket concepts are being examined in a series of studies potential replacements for the Space Shuttle launch system in the 2000-2010 time frame. Rockwell International Corporation, under contract to the NASA Langley Research Center, has analyzed a two-stage all-rocket concept to determine whether this class of vehicles is appropriate for the AMLS function. The results of the pre-phase A study are discussed.

Advanced Extravehicular Protective System (AEPS) study

NASA Technical Reports Server (NTRS)

Williams, J. L.; Webbon, B. W.; Copeland, R. J.

1972-01-01

A summary is presented of Advanced Extravehicular Protective Systems (AEPS) for the future missions beyond Skylab in earth orbit, on the lunar surface, and on the Martian surface. The study concentrated on the origination of regenerable life support concepts for use in portable extravehicular protective systems, and included evaluation and comparison with expendable systems, and selection of life support subsystems. The study was conducted in two phases. In the first phase, subsystem concepts for performing life support functions in AEPS which are regenerable or partially regenerable were originated, and in addition, expendable subsystems were considered. Parametric data for each subsystem concept were evolved including subsystem weight and volume, power requirement, thermal control requirement; base regeneration equipment weight and volume, requirement. The second phase involved an evaluation of the impact of safety considerations involving redundant and/or backup systems on the selection of the regenerable life support subsystems. In addition, the impact of the space shuttle program on regenerable life support subsystem development was investigated.

GIS Based Application of Advanced Traveler Information System in India

NASA Astrophysics Data System (ADS)

Kumar, P.; Singh, V.

2012-02-01

Developed countries like USA, Canada, Japan, UK, Australia and Germany have adopted advanced traveler information technologies expeditiously in comparison to developing countries. But, unlike developed countries, developing countries face considerable financial and framework constraints. Moreover local traffic, roadway, signalization, demographic, topological and social conditions in developing countries are quite different from those in developed countries. In this paper, a comprehensive framework comprising of system architecture, development methodology and salient features of a developed Advanced Traveler Information System (ATIS) for metropolitan cities in developing countries has been discussed. Development of proposed system is based on integration of two well known information technologies viz. Geographic Information Systems (GIS) and World Wide Web (WWW). Combination of these technologies can be utilized to develop an integrated ATIS that targets different types of travelers like private vehicle owners, transit users and casual outside visitors.

Recent advances in nondestructive evaluation made possible by novel uses of video systems

NASA Technical Reports Server (NTRS)

Generazio, Edward R.; Roth, Don J.

1990-01-01

Complex materials are being developed for use in future advanced aerospace systems. High temperature materials have been targeted as a major area of materials development. The development of composites consisting of ceramic matrix and ceramic fibers or whiskers is currently being aggressively pursued internationally. These new advanced materials are difficult and costly to produce; however, their low density and high operating temperature range are needed for the next generation of advanced aerospace systems. These materials represent a challenge to the nondestructive evaluation community. Video imaging techniques not only enhance the nondestructive evaluation, but they are also required for proper evaluation of these advanced materials. Specific research examples are given, highlighting the impact that video systems have had on the nondestructive evaluation of ceramics. An image processing technique for computerized determination of grain and pore size distribution functions from microstructural images is discussed. The uses of video and computer systems for displaying, evaluating, and interpreting ultrasonic image data are presented.

Natural circulating passive cooling system for nuclear reactor containment structure

DOEpatents

Gou, Perng-Fei; Wade, Gentry E.

1990-01-01

A passive cooling system for the contaminant structure of a nuclear reactor plant providing protection against overpressure within the containment attributable to inadvertent leakage or rupture of the system components. The cooling system utilizes natural convection for transferring heat imbalances and enables the discharge of irradiation free thermal energy to the atmosphere for heat disposal from the system.

Advanced Polymers Containing the Phenyltrifluoroethylidene Connecting Group

NASA Technical Reports Server (NTRS)

Alstron, William B.; Sivko, Gloria S.

2006-01-01

A new, lower cost fluorinated dianhydride based on the phenyltrifluoroethylidene (3F) connecting linkage was invented by the principal author in the early 1980's. New 3F condensation and addition cured polyimides were synthesized with the newly discovered 3F dianhydride and the previously known 3F diamine. As controls, polyimides based on the somewhat analogous higher cost hexafluoroisopropylidene (6F) linkage were also prepared. The short term thermal oxidative stability (TOS), determined by thermal gravimetric analysis (TGA), and the glass transition temperatures (Tg) of 3F dianhydride polyimides were found to be similar to 6F dianhydride polyimides, but the Tg was slightly higher for 3F diamine polyimides than 6F diamine polyimides. Unfortunately, in real time testing, long term TOS of 3F polymers was clearly inferior to 6F polymers. This was due to a 3 to 5 fold greater rate of loss of trifluoromethyl group from 3F versus 6F linkages. However, at shorter times or lower temperatures, 3F TOS was almost comparable to 6F TOS. The wide scope of the 3F technology was also demonstrated to have distinct unique advantages over 6F technology through the use of the 3F pendant phenyl ring as a synthetic site to introduce other functional groups. These groups have been used for the control or modification of polymer properties; an advantage lacking within 6F technology. The synthetic ease by which 3F can be introduced into various types of monomers has lead to the explosion of advanced 3F polyimides and other high performance advanced 3F polymers in the prior decade of 3F polymer literature as cited herein; covering polyimides, substituted polyimides, at least ten types of nonpolyimide 3F polymer modifications, and also the government's nine 3F U.S. patents and corporations' nine 3F U.S. patents.

Cancer Research Advance in CKLF-like MARVEL Transmembrane Domain Containing Member Family (Review).

PubMed

Lu, Jia; Wu, Qian-Qian; Zhou, Ya-Bo; Zhang, Kai-Hua; Pang, Bing-Xin; Li, Liang; Sun, Nan; Wang, Heng-Shu; Zhang, Song; Li, Wen-Jian; Zheng, Wei; Liu, Wei

2016-01-01

CKLF-like MARVEL transmembrane domain-containing family (CMTM) is a novel family of genes first reported at international level by Peking University Human Disease Gene Research Center. The gene products are between chemokines and the transmembrane-4 superfamily. Loaceted in several human chromosomes, CMTMs, which are unregulated in kinds of tumors, are potential tumor suppressor genes consisting of CKLF and CMTM1 to CMTM8. CMTMs play important roles in immune, male reproductive and hematopoietic systems. Also, it has been approved that CMTM family has strong connection with diseases of autoimmunity, haematopoietic system and haematopoietic system. The in-depth study in recent years found the close relation between CMTMs and umorigenesis, tumor development and metastasis. CMTM family has a significant clinical value in diagnosis and treatment to the diseases linking to tumor and immune system.

Advanced electronics for the CTF MEG system.

PubMed

McCubbin, J; Vrba, J; Spear, P; McKenzie, D; Willis, R; Loewen, R; Robinson, S E; Fife, A A

2004-11-30

Development of the CTF MEG system has been advanced with the introduction of a computer processing cluster between the data acquisition electronics and the host computer. The advent of fast processors, memory, and network interfaces has made this innovation feasible for large data streams at high sampling rates. We have implemented tasks including anti-alias filter, sample rate decimation, higher gradient balancing, crosstalk correction, and optional filters with a cluster consisting of 4 dual Intel Xeon processors operating on up to 275 channel MEG systems at 12 kHz sample rate. The architecture is expandable with additional processors to implement advanced processing tasks which may include e.g., continuous head localization/motion correction, optional display filters, coherence calculations, or real time synthetic channels (via beamformer). We also describe an electronics configuration upgrade to provide operator console access to the peripheral interface features such as analog signal and trigger I/O. This allows remote location of the acoustically noisy electronics cabinet and fitting of the cabinet with doors for improved EMI shielding. Finally, we present the latest performance results available for the CTF 275 channel MEG system including an unshielded SEF (median nerve electrical stimulation) measurement enhanced by application of an adaptive beamformer technique (SAM) which allows recognition of the nominal 20-ms response in the unaveraged signal.

Design of an advanced flight planning system

NASA Technical Reports Server (NTRS)

Sorensen, J. A.; Goka, T.

1985-01-01

The demand for both fuel conservation and four-dimensional traffic management require that the preflight planning process be designed to account for advances in airborne flight management and weather forecasting. The steps and issues in designing such an advanced flight planning system are presented. Focus is placed on the different optimization options for generating the three-dimensional reference path. For the cruise phase, one can use predefined jet routes, direct routes based on a network of evenly spaced grid points, or a network where the grid points are existing navaid locations. Each choice has its own problem in determining an optimum solution. Finding the reference path is further complicated by choice of cruise altitude levels, use of a time-varying weather field, and requiring a fixed time-of-arrival (four-dimensional problem).

Advanced Command Destruct System (ACDS) Enhanced Flight Termination System (EFTS)

NASA Technical Reports Server (NTRS)

Tow, David

2009-01-01

NASA Dryden started working towards a single vehicle enhanced flight termination system (EFTS) in January 2008. NASA and AFFTC combined their efforts to work towards final operating capability for multiple vehicle and multiple missions simultaneously, to be completed by the end of 2011. Initially, the system was developed to support one vehicle and one frequency per mission for unmanned aerial vehicles (UAVs) at NASA Dryden. By May 2008 95% of design and hardware builds were completed, however, NASA Dryden's change of software safety scope and requirements caused delays after May 2008. This presentation reviews the initial and final operating capabilities for the Advanced Command Destruct System (ACDS), including command controller and configuration software development. A requirements summary is also provided.

Advanced Avionics and Processor Systems for Space and Lunar Exploration

NASA Technical Reports Server (NTRS)

Keys, Andrew S.; Adams, James H.; Ray, Robert E.; Johnson, Michael A.; Cressler, John D.

2009-01-01

NASA's newly named Advanced Avionics and Processor Systems (AAPS) project, formerly known as the Radiation Hardened Electronics for Space Environments (RHESE) project, endeavors to mature and develop the avionic and processor technologies required to fulfill NASA's goals for future space and lunar exploration. Over the past year, multiple advancements have been made within each of the individual AAPS technology development tasks that will facilitate the success of the Constellation program elements. This paper provides a brief review of the project's recent technology advancements, discusses their application to Constellation projects, and addresses the project's plans for the coming year.

Study of advanced electric propulsion system concept using a flywheel for electric vehicles

NASA Technical Reports Server (NTRS)

Younger, F. C.; Lackner, H.

1979-01-01

Advanced electric propulsion system concepts with flywheels for electric vehicles are evaluated and it is predicted that advanced systems can provide considerable performance improvement over existing electric propulsion systems with little or no cost penalty. Using components specifically designed for an integrated electric propulsion system avoids the compromises that frequently lead to a loss of efficiency and to inefficient utilization of space and weight. A propulsion system using a flywheel power energy storage device can provide excellent acceleration under adverse conditions of battery degradation due either to very low temperatures or high degrees of discharge. Both electrical and mechanical means of transfer of energy to and from the flywheel appear attractive; however, development work is required to establish the safe limits of speed and energy storage for advanced flywheel designs and to achieve the optimum efficiency of energy transfer. Brushless traction motor designs using either electronic commutation schemes or dc-to-ac inverters appear to provide a practical approach to a mass producible motor, with excellent efficiency and light weight. No comparisons were made with advanced system concepts which do not incorporate a flywheel.

Pressure suppression containment system for boiling water reactor

DOEpatents

Gluntz, Douglas M.; Nesbitt, Loyd B.

1997-01-01

A system for suppressing the pressure inside the containment of a BWR following a postulated accident. A piping subsystem is provided which features a main process pipe that communicates the wetwell airspace to a connection point downstream of the guard charcoal bed in an offgas system and upstream of the main bank of delay charcoal beds which give extensive holdup to offgases. The main process pipe is fitted with both inboard and outboard containment isolation valves. Also incorporated in the main process pipe is a low-differential-pressure rupture disk which prevents any gas outflow in this piping whatsoever until or unless rupture occurs by virtue of pressure inside this main process pipe on the wetwell airspace side of the disk exceeding the design opening (rupture) pressure differential. The charcoal holds up the radioactive species in the noncondensable gas from the wetwell plenum by adsorption, allowing time for radioactive decay before the gas is vented to the environs.

Pressure suppression containment system for boiling water reactor

DOEpatents

Gluntz, D.M.; Nesbitt, L.B.

1997-01-21

A system is disclosed for suppressing the pressure inside the containment of a BWR following a postulated accident. A piping subsystem is provided which features a main process pipe that communicates the wetwell airspace to a connection point downstream of the guard charcoal bed in an offgas system and upstream of the main bank of delay charcoal beds which give extensive holdup to offgases. The main process pipe is fitted with both inboard and outboard containment isolation valves. Also incorporated in the main process pipe is a low-differential-pressure rupture disk which prevents any gas outflow in this piping whatsoever until or unless rupture occurs by virtue of pressure inside this main process pipe on the wetwell airspace side of the disk exceeding the design opening (rupture) pressure differential. The charcoal holds up the radioactive species in the noncondensable gas from the wetwell plenum by adsorption, allowing time for radioactive decay before the gas is vented to the environs. 3 figs.

Final Report Advanced Quasioptical Launcher System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jeffrey Neilson

2010-04-30

This program developed an analytical design tool for designing antenna and mirror systems to convert whispering gallery RF modes to Gaussian or HE11 modes. Whispering gallery modes are generated by gyrotrons used for electron cyclotron heating of fusion plasmas in tokamaks. These modes cannot be easily transmitted and must be converted to free space or waveguide modes compatible with transmission line systems.This program improved the capability of SURF3D/LOT, which was initially developed in a previous SBIR program. This suite of codes revolutionized quasi-optical launcher design, and this code, or equivalent codes, are now used worldwide. This program added functionality tomore » SURF3D/LOT to allow creating of more compact launcher and mirror systems and provide direct coupling to corrugated waveguide within the vacuum envelope of the gyrotron. Analysis was also extended to include full-wave analysis of mirror transmission line systems. The code includes a graphical user interface and is available for advanced design of launcher systems.« less

Study of Pu consumption in advanced light water reactors: Evaluation of GE advanced boiling water reactor plants - compilation of Phase 1B task reports

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1993-09-15

This report contains an extensive evaluation of GE advanced boiling water reactor plants prepared for United State Department of Energy. The general areas covered in this report are: core and system performance; fuel cycle; infrastructure and deployment; and safety and environmental approval.

IEDA Thesaurus: A Controlled Vocabulary for IEDA Systems to Advance Integration

NASA Astrophysics Data System (ADS)

Ji, P.; Lehnert, K. A.; Arko, R. A.; Song, L.; Hsu, L.; Carter, M. R.; Ferrini, V. L.; Ash, J.

2014-12-01

Integrated Earth Data Applications (IEDA) is a community-based facility that serves to support, sustain, and advance the geosciences by providing data services for observational geoscience data from the Ocean, Earth, and Polar Sciences. Many dedicated systems such as the Petrological Database (PetDB), Marine Geoscience Data System (MGDS), System for Earth Sample Registration (SESAR), Data Coordination Center for the U.S. Antarctic Program (USAP-DCC), etc., under the umbrella of the IEDA framework, were developed to support the preservation, discovery, retrieval, and analysis of a wide range of observational field and analytical data types from diverse communities. However, it is currently difficult to maintain consistency of indexing content within IEDA schema, and perform unified or precise searching of the data in these diverse systems as each system maintains separate vocabularies, hierarchies, authority files, or sub taxonomies. We present here the IEDA Thesaurus, a system, which combines existing separate controlled vocabularies from the different systems under the IEDA schema into a single master controlled vocabulary, also introducing some new top facets for future long-term use. The IEDA thesaurus contains structured terminology for petrology, geochemistry, sedimentology, oceanography, geochronology, and volcanology, and other general metadata fields. 18 top facets (also called 'top categories') are defined, including equipment, geographic gazetteer, geologic ages, geologic units, materials, etc. The terms of the thesaurus are cross validated with others popular geoscience vocabularies such as GeoRef Thesaurus, U.S. Geological Survey Library Classification System, Global Change Master Directory (GCMD), and Semantic Web for Earth and Environmental Terminology (SWEET) ontologies. The thesaurus is organized along with the ANSI/NISO Z39.19-2005 Guidelines for the Construction, Format, and Management of Monolingual Controlled Vocabularies, and is published using

Advanced building energy management system demonstration for Department of Defense buildings.

PubMed

O'Neill, Zheng; Bailey, Trevor; Dong, Bing; Shashanka, Madhusudana; Luo, Dong

2013-08-01

This paper presents an advanced building energy management system (aBEMS) that employs advanced methods of whole-building performance monitoring combined with statistical methods of learning and data analysis to enable identification of both gradual and discrete performance erosion and faults. This system assimilated data collected from multiple sources, including blueprints, reduced-order models (ROM) and measurements, and employed advanced statistical learning algorithms to identify patterns of anomalies. The results were presented graphically in a manner understandable to facilities managers. A demonstration of aBEMS was conducted in buildings at Naval Station Great Lakes. The facility building management systems were extended to incorporate the energy diagnostics and analysis algorithms, producing systematic identification of more efficient operation strategies. At Naval Station Great Lakes, greater than 20% savings were demonstrated for building energy consumption by improving facility manager decision support to diagnose energy faults and prioritize alternative, energy-efficient operation strategies. The paper concludes with recommendations for widespread aBEMS success. © 2013 New York Academy of Sciences.

Hybrid and electric advanced vehicle systems (heavy) simulation

NASA Technical Reports Server (NTRS)

Hammond, R. A.; Mcgehee, R. K.

1981-01-01

A computer program to simulate hybrid and electric advanced vehicle systems (HEAVY) is described. It is intended for use early in the design process: concept evaluation, alternative comparison, preliminary design, control and management strategy development, component sizing, and sensitivity studies. It allows the designer to quickly, conveniently, and economically predict the performance of a proposed drive train. The user defines the system to be simulated using a library of predefined component models that may be connected to represent a wide variety of propulsion systems. The development of three models are discussed as examples.

The Challenges of Creating a Real-Time Data Management System for TRU-Mixed Waste at the Advanced Mixed Waste Treatment Plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paff, S. W; Doody, S.

2003-02-25

This paper discusses the challenges associated with creating a data management system for waste tracking at the Advanced Mixed Waste Treatment Plant (AMWTP) at the Idaho National Engineering Lab (INEEL). The waste tracking system combines data from plant automation systems and decision points. The primary purpose of the system is to provide information to enable the plant operators and engineers to assess the risks associated with each container and determine the best method of treating it. It is also used to track the transuranic (TRU) waste containers as they move throughout the various processes at the plant. And finally, themore » goal of the system is to support paperless shipments of the waste to the Waste Isolation Pilot Plant (WIPP). This paper describes the approach, methodologies, the underlying design of the database, and the challenges of creating the Data Management System (DMS) prior to completion of design and construction of a major plant. The system was built utilizing an Oracle database platform, and Oracle Forms 6i in client-server mode. The underlying data architecture is container-centric, with separate tables and objects for each type of analysis used to characterize the waste, including real-time radiography (RTR), non-destructive assay (NDA), head-space gas sampling and analysis (HSGS), visual examination (VE) and coring. The use of separate tables facilitated the construction of automatic interfaces with the analysis instruments that enabled direct data capture. Movements are tracked using a location system describing each waste container's current location and a history table tracking the container's movement history. The movement system is designed to interface both with radio-frequency bar-code devices and the plant's integrated control system (ICS). Collections of containers or information, such as batches, were created across the various types of analyses, which enabled a single, cohesive approach to be developed for verification and

Beyond the Baseline: Proceedings of the Space Station Evolution Symposium. Volume 2, Part 2; Space Station Freedom Advanced Development Program

NASA Technical Reports Server (NTRS)

1990-01-01

This report contains the individual presentations delivered at the Space Station Evolution Symposium in League City, Texas on February 6, 7, 8, 1990. Personnel responsible for Advanced Systems Studies and Advanced Development within the Space Station Freedom program reported on the results of their work to date. Systems Studies presentations focused on identifying the baseline design provisions (hooks and scars) necessary to enable evolution of the facility to support changing space policy and anticipated user needs. Also emphasized were evolution configuration and operations concepts including on-orbit processing of space transfer vehicles. Advanced Development task managers discussed transitioning advanced technologies to the baseline program, including those near-term technologies which will enhance the safety and productivity of the crew and the reliability of station systems. Special emphasis was placed on applying advanced automation technology to ground and flight systems. This publication consists of two volumes. Volume 1 contains the results of the advanced system studies with the emphasis on reference evolution configurations, system design requirements and accommodations, and long-range technology projections. Volume 2 reports on advanced development tasks within the Transition Definition Program. Products of these tasks include: engineering fidelity demonstrations and evaluations on Station development testbeds and Shuttle-based flight experiments; detailed requirements and performance specifications which address advanced technology implementation issues; and mature applications and the tools required for the development, implementation, and support of advanced technology within the Space Station Freedom Program.

Planner-Based Control of Advanced Life Support Systems

NASA Technical Reports Server (NTRS)

Muscettola, Nicola; Kortenkamp, David; Fry, Chuck; Bell, Scott

2005-01-01

The paper describes an approach to the integration of qualitative and quantitative modeling techniques for advanced life support (ALS) systems. Developing reliable control strategies that scale up to fully integrated life support systems requires augmenting quantitative models and control algorithms with the abstractions provided by qualitative, symbolic models and their associated high-level control strategies. This will allow for effective management of the combinatorics due to the integration of a large number of ALS subsystems. By focusing control actions at different levels of detail and reactivity we can use faster: simpler responses at the lowest level and predictive but complex responses at the higher levels of abstraction. In particular, methods from model-based planning and scheduling can provide effective resource management over long time periods. We describe reference implementation of an advanced control system using the IDEA control architecture developed at NASA Ames Research Center. IDEA uses planning/scheduling as the sole reasoning method for predictive and reactive closed loop control. We describe preliminary experiments in planner-based control of ALS carried out on an integrated ALS simulation developed at NASA Johnson Space Center.

Advances in Structures for Large Space Systems

NASA Technical Reports Server (NTRS)

Belvin, W. Keith

2004-01-01

The development of structural systems for scientific remote sensing and space exploration has been underway for four decades. The seminal work from 1960 to 1980 provided the basis for many of the design principles of modern space systems. From 1980- 2000 advances in active materials and structures and the maturing of composites technology led to high precision active systems such those used in the Space Interferometry Mission. Recently, thin-film membrane or gossamer structures are being investigated for use in large area space systems because of their low mass and high packaging efficiency. Various classes of Large Space Systems (LSS) are defined in order to describe the goals and system challenges in structures and materials technologies. With an appreciation of both past and current technology developments, future technology challenges are used to develop a list of technology investments that can have significant impacts on LSS development.

Cargo container inspection test program at ARPA's Nonintrusive Inspection Technology Testbed

NASA Astrophysics Data System (ADS)

Volberding, Roy W.; Khan, Siraj M.

1994-10-01

An x-ray-based cargo inspection system test program is being conducted at the Advanced Research Project Agency (ARPA)-sponsored Nonintrusive Inspection Technology Testbed (NITT) located in the Port of Tacoma, Washington. The test program seeks to determine the performance that can be expected from a dual, high-energy x-ray cargo inspection system when inspecting ISO cargo containers. This paper describes an intensive, three-month, system test involving two independent test groups, one representing the criminal smuggling element and the other representing the law enforcement community. The first group, the `Red Team', prepares ISO containers for inspection at an off-site facility. An algorithm randomly selects and indicates the positions and preparation of cargoes within a container. The prepared container is dispatched to the NITT for inspection by the `Blue Team'. After in-gate processing, it is queued for examination. The Blue Team inspects the container and decides whether or not to pass the container. The shipment undergoes out-gate processing and returns to the Red Team. The results of the inspection are recorded for subsequent analysis. The test process, including its governing protocol, the cargoes, container preparation, the examination and results available at the time of submission are presented.

Inventory & analysis of Advanced Public Transportation Systems in Florida

DOT National Transportation Integrated Search

2001-09-01

Through its National Center for Transit Research, and under contract with the Florida Department of Transportation, the Center for Urban Transportation Research has conducted an inventory of current and planned Advanced Public Transportation Systems ...

Impacts of an advanced public transportation system : demonstration project

DOT National Transportation Integrated Search

1999-10-01

In 1997, the Ann Arbor (Michigan) Transportation Authority began deploying a set of integrated : advanced public transportation system technologies in its vehicles, stations and control center. This paper summarizes selected findings of a multidimens...

Systems integration and demonstration of advanced reusable structure for ALS

NASA Technical Reports Server (NTRS)

Gibbins, Martin N.

1991-01-01

The objective was to investigate the potential of advanced material to achieve life cycle cost (LCC) benefits for reusable structure on the advanced launch system. Three structural elements were investigated - all components of an Advanced Launch System reusable propulsion/avionics module. Leading aeroshell configurations included sandwich structure using titanium, graphite/polyimide (Gr/PI), or high-temperature aluminum (HTA) face sheets. Thrust structure truss concepts used titanium, graphite/epoxy, or silicon carbide/aluminum struts. Leading aft bulkhead concepts employed graphite epoxy and aluminum. The technical effort focused on the aeroshell because the greatest benefits were expected there. Thermal analyses show the structural temperature profiles during operation. Finite element analyses show stresses during splash-down. Weight statements and manufacturing cost estimates were prepared for calculation of LCC for each design. The Gr/PI aeroshell showed the lowest potential LCC, but the HTA aeroshell was judged to be lower risk. A technology development plan was prepared to validate the applicable structural technology.

NASCOM system development plan: System description, capabilities, and plans, FY 94-2

NASA Technical Reports Server (NTRS)

1994-01-01

The Nascom System Development Plan (NSDP) for FY 94-2 contains 17 sections. It is a management document containing the approved plan for maintaining the Nascom Network System. Topics covered include an overview of Nascom systems and services, major ground communication support systems, low-speed data system, voice system, high-speed data system, Nascom support for NASA networks, Nascom planning for NASA missions, and network upgrade and advanced systems developments and plans.

Advanced teleprocessing systems

NASA Astrophysics Data System (ADS)

Kleinrock, L.; Gerla, M.

1982-09-01

This Annual Technical Report covers research covering the period from October 1, 1981 to September 30, 1982. This contract has three primary designated research areas: packet radio systems, resource sharing and allocation, and distributed processing and control. This report contains abstracts of publications which summarize research results in these areas followed by the main body of the report which is devoted to a study of channel access protocols that are executed by the nodes of a network to schedule their transmissions on multi-access broadcast channel. In particular the main body consists of a Ph.D. dissertation, Channel Access Protocols for Multi-Hop Broadcast Packet Radio Networks. This work discusses some new channel access protocols useful for mobile radio networks. Included is an analysis of slotted ALOHA and some tight bounds on the performance of all possible protocols in a mobile environment.

The ISS Water Processor Catalytic Reactor as a Post Processor for Advanced Water Reclamation Systems

NASA Technical Reports Server (NTRS)

Nalette, Tim; Snowdon, Doug; Pickering, Karen D.; Callahan, Michael

2007-01-01

Advanced water processors being developed for NASA s Exploration Initiative rely on phase change technologies and/or biological processes as the primary means of water reclamation. As a result of the phase change, volatile compounds will also be transported into the distillate product stream. The catalytic reactor assembly used in the International Space Station (ISS) water processor assembly, referred to as Volatile Removal Assembly (VRA), has demonstrated high efficiency oxidation of many of these volatile contaminants, such as low molecular weight alcohols and acetic acid, and is considered a viable post treatment system for all advanced water processors. To support this investigation, two ersatz solutions were defined to be used for further evaluation of the VRA. The first solution was developed as part of an internal research and development project at Hamilton Sundstrand (HS) and is based primarily on ISS experience related to the development of the VRA. The second ersatz solution was defined by NASA in support of a study contract to Hamilton Sundstrand to evaluate the VRA as a potential post processor for the Cascade Distillation system being developed by Honeywell. This second ersatz solution contains several low molecular weight alcohols, organic acids, and several inorganic species. A range of residence times, oxygen concentrations and operating temperatures have been studied with both ersatz solutions to provide addition performance capability of the VRA catalyst.

Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Current and advanced act control system definition study

NASA Technical Reports Server (NTRS)

1982-01-01

The Current and Advanced Technology ACT control system definition tasks of the Integrated Application of Active Controls (IAAC) Technology project within the Energy Efficient Transport Program are summarized. The systems mechanize six active control functions: (1) pitch augmented stability; (2) angle of attack limiting; (3) lateral/directional augmented stability; (4) gust load alleviation; (5) maneuver load control; and (6) flutter mode control. The redundant digital control systems meet all function requirements with required reliability and declining weight and cost as advanced technology is introduced.

Advanced Systems for Monitoring Underwater Sounds

NASA Technical Reports Server (NTRS)

Lane, Michael; Van Meter, Steven; Gilmore, Richard Grant; Sommer, Keith

2007-01-01

The term "Passive Acoustic Monitoring System" (PAMS) describes a developmental sensing-and-data-acquisition system for recording underwater sounds. The sounds (more precisely, digitized and preprocessed versions from acoustic transducers) are subsequently analyzed by a combination of data processing and interpretation to identify and/or, in some cases, to locate the sources of those sounds. PAMS was originally designed to locate the sources such as fish of species that one knows or seeks to identify. The PAMS unit could also be used to locate other sources, for example, marine life, human divers, and/or vessels. The underlying principles of passive acoustic sensing and analyzing acoustic-signal data in conjunction with temperature and salinity data are not new and not unique to PAMS. Part of the uniqueness of the PAMS design is that it is the first deep-sea instrumentation design to provide a capability for studying soniferous marine animals (especially fish) over the wide depth range described below. The uniqueness of PAMS also lies partly in a synergistic combination of advanced sensing, packaging, and data-processing design features with features adapted from proven marine instrumentation systems. This combination affords a versatility that enables adaptation to a variety of undersea missions using a variety of sensors. The interpretation of acoustic data can include visual inspection of power-spectrum plots for identification of spectral signatures of known biological species or artificial sources. Alternatively or in addition, data analysis could include determination of relative times of arrival of signals at different acoustic sensors arrayed at known locations. From these times of arrival, locations of acoustic sources (and errors in those locations) can be estimated. Estimates of relative locations of sources and sensors can be refined through analysis of the attenuation of sound in the intervening water in combination with water-temperature and salinity

Advanced orbiting systems test-bedding and protocol verification

NASA Technical Reports Server (NTRS)

Noles, James; De Gree, Melvin

1989-01-01

The Consultative Committee for Space Data Systems (CCSDS) has begun the development of a set of protocol recommendations for Advanced Orbiting Systems (SOS). The AOS validation program and formal definition of AOS protocols are reviewed, and the configuration control of the AOS formal specifications is summarized. Independent implementations of the AOS protocols by NASA and ESA are discussed, and cross-support/interoperability tests which will allow the space agencies of various countries to share AOS communication facilities are addressed.

Advanced Video Data-Acquisition System For Flight Research

NASA Technical Reports Server (NTRS)

Miller, Geoffrey; Richwine, David M.; Hass, Neal E.

1996-01-01

Advanced video data-acquisition system (AVDAS) developed to satisfy variety of requirements for in-flight video documentation. Requirements range from providing images for visualization of airflows around fighter airplanes at high angles of attack to obtaining safety-of-flight documentation. F/A-18 AVDAS takes advantage of very capable systems like NITE Hawk forward-looking infrared (FLIR) pod and recent video developments like miniature charge-couple-device (CCD) color video cameras and other flight-qualified video hardware.

Investigation of Advanced Counterrotation Blade Configuration Concepts for High Speed Turboprop Systems. Task 3: Advanced Fan Section Grid Generator Final Report and Computer Program User's Manual

NASA Technical Reports Server (NTRS)

Crook, Andrew J.; Delaney, Robert A.

1991-01-01

A procedure is studied for generating three-dimensional grids for advanced turbofan engine fan section geometries. The procedure constructs a discrete mesh about engine sections containing the fan stage, an arbitrary number of axisymmetric radial flow splitters, a booster stage, and a bifurcated core/bypass flow duct with guide vanes. The mesh is an h-type grid system, the points being distributed with a transfinite interpolation scheme with axial and radial spacing being user specified. Elliptic smoothing of the grid in the meridional plane is a post-process option. The grid generation scheme is consistent with aerodynamic analyses utilizing the average-passage equation system developed by Dr. John Adamczyk of NASA Lewis. This flow solution scheme requires a series of blade specific grids each having a common axisymmetric mesh, but varying in the circumferential direction according to the geometry of the specific blade row.

Data Compression Techniques for Advanced Space Transportation Systems

NASA Technical Reports Server (NTRS)

Bradley, William G.

1998-01-01

Advanced space transportation systems, including vehicle state of health systems, will produce large amounts of data which must be stored on board the vehicle and or transmitted to the ground and stored. The cost of storage or transmission of the data could be reduced if the number of bits required to represent the data is reduced by the use of data compression techniques. Most of the work done in this study was rather generic and could apply to many data compression systems, but the first application area to be considered was launch vehicle state of health telemetry systems. Both lossless and lossy compression techniques were considered in this study.

Integrated intelligent systems in advanced reactor control rooms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beckmeyer, R.R.

1989-01-01

An intelligent, reactor control room, information system is designed to be an integral part of an advanced control room and will assist the reactor operator's decision making process by continuously monitoring the current plant state and providing recommended operator actions to improve that state. This intelligent system is an integral part of, as well as an extension to, the plant protection and control systems. This paper describes the interaction of several functional components (intelligent information data display, technical specifications monitoring, and dynamic procedures) of the overall system and the artificial intelligence laboratory environment assembled for testing the prototype. 10 refs.,more » 5 figs.« less

A survey of advanced battery systems for space applications

NASA Technical Reports Server (NTRS)

Attia, Alan I.

1989-01-01

The results of a survey on advanced secondary battery systems for space applications are presented. Fifty-five battery experts from government, industry and universities participated in the survey by providing their opinions on the use of several battery types for six space missions, and their predictions of likely technological advances that would impact the development of these batteries. The results of the survey predict that only four battery types are likely to exceed a specific energy of 150 Wh/kg and meet the safety and reliability requirements for space applications within the next 15 years.

7 CFR 29.68 - Advance information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Advance information. 29.68 Section 29.68 Agriculture... INSPECTION Regulations Permissive Inspection § 29.68 Advance information. Upon the request of an applicant.... Information relative to grade or other determinations contained or to be contained in a certificate shall not...

North Seattle advanced traffic management system (NSATMS) project evaluation

DOT National Transportation Integrated Search

2002-12-01

This report documents the findings of the evaluation of the North Seattle Advanced Traffic Management System (NSATMS) Project. The evaluation was originally designed to analyze the potential transportation benefits and costs of a regional arterial tr...

Advanced Technology for Engineering Education

NASA Technical Reports Server (NTRS)

Noor, Ahmed K. (Compiler); Malone, John B. (Compiler)

1998-01-01

This document contains the proceedings of the Workshop on Advanced Technology for Engineering Education, held at the Peninsula Graduate Engineering Center, Hampton, Virginia, February 24-25, 1998. The workshop was jointly sponsored by the University of Virginia's Center for Advanced Computational Technology and NASA. Workshop attendees came from NASA, other government agencies, industry and universities. The objectives of the workshop were to assess the status of advanced technologies for engineering education and to explore the possibility of forming a consortium of interested individuals/universities for curriculum reform and development using advanced technologies. The presentations covered novel delivery systems and several implementations of new technologies for engineering education. Certain materials and products are identified in this publication in order to specify adequately the materials and products that were investigated in the research effort. In no case does such identification imply recommendation or endorsement of products by NASA, nor does it imply that the materials and products are the only ones or the best ones available for this purpose. In many cases equivalent materials and products are available and would probably produce equivalent results.

Advanced Life Support System Value Metric

NASA Technical Reports Server (NTRS)

Jones, Harry W.; Arnold, James O. (Technical Monitor)

1999-01-01

The NASA Advanced Life Support (ALS) Program is required to provide a performance metric to measure its progress in system development. Extensive discussions within the ALS program have reached a consensus. The Equivalent System Mass (ESM) metric has been traditionally used and provides a good summary of the weight, size, and power cost factors of space life support equipment. But ESM assumes that all the systems being traded off exactly meet a fixed performance requirement, so that the value and benefit (readiness, performance, safety, etc.) of all the different systems designs are exactly equal. This is too simplistic. Actual system design concepts are selected using many cost and benefit factors and the system specification is then set accordingly. The ALS program needs a multi-parameter metric including both the ESM and a System Value Metric (SVM). The SVM would include safety, maintainability, reliability, performance, use of cross cutting technology, and commercialization potential. Another major factor in system selection is technology readiness level (TRL), a familiar metric in ALS. The overall ALS system metric that is suggested is a benefit/cost ratio, [SVM + TRL]/ESM, with appropriate weighting and scaling. The total value is the sum of SVM and TRL. Cost is represented by ESM. The paper provides a detailed description and example application of the suggested System Value Metric.

Advanced Flow Control as a Management Tool in the National Airspace System

NASA Technical Reports Server (NTRS)

Wugalter, S.

1974-01-01

Advanced Flow Control is closely related to Air Traffic Control. Air Traffic Control is the business of the Federal Aviation Administration. To formulate an understanding of advanced flow control and its use as a management tool in the National Airspace System, it becomes necessary to speak somewhat of air traffic control, the role of FAA, and their relationship to advanced flow control. Also, this should dispell forever, any notion that advanced flow control is the inspirational master valve scheme to be used on the Alaskan Oil Pipeline.

Advanced Research Deposition System (ARDS) for processing CdTe solar cells

NASA Astrophysics Data System (ADS)

Barricklow, Keegan Corey

CdTe solar cells have been commercialized at the Gigawatt/year level. The development of volume manufacturing processes for next generation CdTe photovoltaics (PV) with higher efficiencies requires research systems with flexibility, scalability, repeatability and automation. The Advanced Research Deposition Systems (ARDS) developed by the Materials Engineering Laboratory (MEL) provides such a platform for the investigation of materials and manufacturing processes necessary to produce the next generation of CdTe PV. Limited by previous research systems, the ARDS was developed to provide process and hardware flexibility, accommodating advanced processing techniques, and capable of producing device quality films. The ARDS is a unique, in-line process tool with nine processing stations. The system was designed, built and assembled at the Materials Engineering Laboratory. Final assembly, startup, characterization and process development are the focus of this research. Many technical challenges encountered during the startup of the ARDS were addressed in this research. In this study, several hardware modifications needed for the reliable operation of the ARDS were designed, constructed and successfully incorporated into the ARDS. The effect of process condition on film properties for each process step was quantified. Process development to achieve 12% efficient baseline solar cell required investigation of discrete processing steps, troubleshooting process variation, and developing performance correlations. Subsequent to this research, many advances have been demonstrated with the ARDS. The ARDS consistently produces devices of 12% +/-.5% by the process of record (POR). The champion cell produced to date utilizing the ARDS has an efficiency of 16.2% on low cost commercial sodalime glass and utilizes advanced films. The ARDS has enabled investigation of advanced concepts for processing CdTe devices including, Plasma Cleaning, Plasma Enhanced Closed Space Sublimation

Investigation of advanced counterrotation blade configuration concepts for high speed turboprop systems. Task 4: Advanced fan section aerodynamic analysis computer program user's manual

NASA Technical Reports Server (NTRS)

Crook, Andrew J.; Delaney, Robert A.

1992-01-01

The computer program user's manual for the ADPACAPES (Advanced Ducted Propfan Analysis Code-Average Passage Engine Simulation) program is included. The objective of the computer program is development of a three-dimensional Euler/Navier-Stokes flow analysis for fan section/engine geometries containing multiple blade rows and multiple spanwise flow splitters. An existing procedure developed by Dr. J. J. Adamczyk and associates at the NASA Lewis Research Center was modified to accept multiple spanwise splitter geometries and simulate engine core conditions. The numerical solution is based upon a finite volume technique with a four stage Runge-Kutta time marching procedure. Multiple blade row solutions are based upon the average-passage system of equations. The numerical solutions are performed on an H-type grid system, with meshes meeting the requirement of maintaining a common axisymmetric mesh for each blade row grid. The analysis was run on several geometry configurations ranging from one to five blade rows and from one to four radial flow splitters. The efficiency of the solution procedure was shown to be the same as the original analysis.

Progress toward an advanced condition monitoring system for reusable rocket engines

NASA Technical Reports Server (NTRS)

Maram, J.; Barkhoudarian, S.

1987-01-01

A new generation of advanced sensor technologies will allow the direct measurement of critical/degradable rocket engine components' health and the detection of degraded conditions before component deterioration affects engine performance, leading to substantial improvements in reusable engines' operation and maintenance. When combined with a computer-based engine condition-monitoring system, these sensors can furnish a continuously updated data base for the prediction of engine availability and advanced warning of emergent maintenance requirements. Attention is given to the case of a practical turbopump and combustion device diagnostic/prognostic health-monitoring system.

The Systems Autonomy Demonstration Project - Catalyst for Space Station advanced automation

NASA Technical Reports Server (NTRS)

Healey, Kathleen J.

1988-01-01

The Systems Autonomy Demonstration Project (SADP) was initiated by NASA to address the advanced automation needs for the Space Station program. The application of advanced automation to the Space Station's operations management system (OMS) is discussed. The SADP's future goals and objectives are discussed with respect to OMS functional requirements, design, and desired evolutionary capabilities. Major technical challenges facing the designers, developers, and users of the OMS are identified in order to guide the definition of objectives, plans, and scenarios for future SADP demonstrations, and to focus the efforts on the supporting research.

The impact of gendered organizational systems on women’s career advancement

PubMed Central

O’Neil, Deborah A.; Hopkins, Margaret M.

2015-01-01

In this Perspective article we propose that in order to pave the way for women’s career advancement into the senior ranks of organizations, attention must be directed at the systemic norms and structures that drive the gendered nature of the workplace. A focus on individual level issues, i.e., women lacking confidence and women opting out, detracts from the work that must be done at the organizational level in order to dismantle the system of pervasive, structural disadvantage facing women seeking to advance to senior leadership positions. PMID:26175708

Institutional and policy issues in adopting advanced public transportation systems technology

DOT National Transportation Integrated Search

1995-09-01

This project, Institutional and Policy Issues in Adopting Advanced Public Transportation Systems Technologies, aimed to study critical mass transportation issues associated with the implementation of intelligent transportation systems (ITS) in the no...

The Environmental Control and Life Support System (ECLSS) advanced automation project

NASA Technical Reports Server (NTRS)

Dewberry, Brandon S.; Carnes, Ray

1990-01-01

The objective of the environmental control and life support system (ECLSS) Advanced Automation Project is to influence the design of the initial and evolutionary Space Station Freedom Program (SSFP) ECLSS toward a man-made closed environment in which minimal flight and ground manpower is needed. Another objective includes capturing ECLSS design and development knowledge future missions. Our approach has been to (1) analyze the SSFP ECLSS, (2) envision as our goal a fully automated evolutionary environmental control system - an augmentation of the baseline, and (3) document the advanced software systems, hooks, and scars which will be necessary to achieve this goal. From this analysis, prototype software is being developed, and will be tested using air and water recovery simulations and hardware subsystems. In addition, the advanced software is being designed, developed, and tested using automation software management plan and lifecycle tools. Automated knowledge acquisition, engineering, verification and testing tools are being used to develop the software. In this way, we can capture ECLSS development knowledge for future use develop more robust and complex software, provide feedback to the knowledge based system tool community, and ensure proper visibility of our efforts.

On advanced configuration enhance adaptive system optimization

NASA Astrophysics Data System (ADS)

Liu, Hua; Ding, Quanxin; Wang, Helong; Guo, Chunjie; Chen, Hongliang; Zhou, Liwei

2017-10-01

For aim to find an effective method to structure to enhance these adaptive system with some complex function and look forward to establish an universally applicable solution in prototype and optimization. As the most attractive component in adaptive system, wave front corrector is constrained by some conventional technique and components, such as polarization dependence and narrow working waveband. Advanced configuration based on a polarized beam split can optimized energy splitting method used to overcome these problems effective. With the global algorithm, the bandwidth has been amplified by more than five times as compared with that of traditional ones. Simulation results show that the system can meet the application requirements in MTF and other related criteria. Compared with the conventional design, the system has reduced in volume and weight significantly. Therefore, the determining factors are the prototype selection and the system configuration, Results show their effectiveness.