On-chip continuous-variable quantum entanglement

NASA Astrophysics Data System (ADS)

Masada, Genta; Furusawa, Akira

2016-09-01

Entanglement is an essential feature of quantum theory and the core of the majority of quantum information science and technologies. Quantum computing is one of the most important fruits of quantum entanglement and requires not only a bipartite entangled state but also more complicated multipartite entanglement. In previous experimental works to demonstrate various entanglement-based quantum information processing, light has been extensively used. Experiments utilizing such a complicated state need highly complex optical circuits to propagate optical beams and a high level of spatial interference between different light beams to generate quantum entanglement or to efficiently perform balanced homodyne measurement. Current experiments have been performed in conventional free-space optics with large numbers of optical components and a relatively large-sized optical setup. Therefore, they are limited in stability and scalability. Integrated photonics offer new tools and additional capabilities for manipulating light in quantum information technology. Owing to integrated waveguide circuits, it is possible to stabilize and miniaturize complex optical circuits and achieve high interference of light beams. The integrated circuits have been firstly developed for discrete-variable systems and then applied to continuous-variable systems. In this article, we review the currently developed scheme for generation and verification of continuous-variable quantum entanglement such as Einstein-Podolsky-Rosen beams using a photonic chip where waveguide circuits are integrated. This includes balanced homodyne measurement of a squeezed state of light. As a simple example, we also review an experiment for generating discrete-variable quantum entanglement using integrated waveguide circuits.

Quantum simulation of quantum field theory using continuous variables

DOE PAGES

Marshall, Kevin; Pooser, Raphael C.; Siopsis, George; ...

2015-12-14

Much progress has been made in the field of quantum computing using continuous variables over the last couple of years. This includes the generation of extremely large entangled cluster states (10,000 modes, in fact) as well as a fault tolerant architecture. This has lead to the point that continuous-variable quantum computing can indeed be thought of as a viable alternative for universal quantum computing. With that in mind, we present a new algorithm for continuous-variable quantum computers which gives an exponential speedup over the best known classical methods. Specifically, this relates to efficiently calculating the scattering amplitudes in scalar bosonicmore » quantum field theory, a problem that is known to be hard using a classical computer. Thus, we give an experimental implementation based on cluster states that is feasible with today's technology.« less

Quantum simulation of quantum field theory using continuous variables

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marshall, Kevin; Pooser, Raphael C.; Siopsis, George

Much progress has been made in the field of quantum computing using continuous variables over the last couple of years. This includes the generation of extremely large entangled cluster states (10,000 modes, in fact) as well as a fault tolerant architecture. This has lead to the point that continuous-variable quantum computing can indeed be thought of as a viable alternative for universal quantum computing. With that in mind, we present a new algorithm for continuous-variable quantum computers which gives an exponential speedup over the best known classical methods. Specifically, this relates to efficiently calculating the scattering amplitudes in scalar bosonicmore » quantum field theory, a problem that is known to be hard using a classical computer. Thus, we give an experimental implementation based on cluster states that is feasible with today's technology.« less

Mutilating Data and Discarding Variance: The Dangers of Dichotomizing Continuous Variables.

ERIC Educational Resources Information Center

Kroff, Michael W.

This paper reviews issues involved in converting continuous variables to nominal variables to be used in the OVA techniques. The literature dealing with the dangers of dichotomizing continuous variables is reviewed. First, the assumptions invoked by OVA analyses are reviewed in addition to concerns regarding the loss of variance and a reduction in…

Continuous variable quantum key distribution with modulated entangled states.

PubMed

Madsen, Lars S; Usenko, Vladyslav C; Lassen, Mikael; Filip, Radim; Andersen, Ulrik L

2012-01-01

Quantum key distribution enables two remote parties to grow a shared key, which they can use for unconditionally secure communication over a certain distance. The maximal distance depends on the loss and the excess noise of the connecting quantum channel. Several quantum key distribution schemes based on coherent states and continuous variable measurements are resilient to high loss in the channel, but are strongly affected by small amounts of channel excess noise. Here we propose and experimentally address a continuous variable quantum key distribution protocol that uses modulated fragile entangled states of light to greatly enhance the robustness to channel noise. We experimentally demonstrate that the resulting quantum key distribution protocol can tolerate more noise than the benchmark set by the ideal continuous variable coherent state protocol. Our scheme represents a very promising avenue for extending the distance for which secure communication is possible.

Extremal entanglement and mixedness in continuous variable systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adesso, Gerardo; Serafini, Alessio; Illuminati, Fabrizio

2004-08-01

We investigate the relationship between mixedness and entanglement for Gaussian states of continuous variable systems. We introduce generalized entropies based on Schatten p norms to quantify the mixedness of a state and derive their explicit expressions in terms of symplectic spectra. We compare the hierarchies of mixedness provided by such measures with the one provided by the purity (defined as tr {rho}{sup 2} for the state {rho}) for generic n-mode states. We then review the analysis proving the existence of both maximally and minimally entangled states at given global and marginal purities, with the entanglement quantified by the logarithmic negativity.more » Based on these results, we extend such an analysis to generalized entropies, introducing and fully characterizing maximally and minimally entangled states for given global and local generalized entropies. We compare the different roles played by the purity and by the generalized p entropies in quantifying the entanglement and the mixedness of continuous variable systems. We introduce the concept of average logarithmic negativity, showing that it allows a reliable quantitative estimate of continuous variable entanglement by direct measurements of global and marginal generalized p entropies.« less

Long-distance continuous-variable quantum key distribution by controlling excess noise

NASA Astrophysics Data System (ADS)

Huang, Duan; Huang, Peng; Lin, Dakai; Zeng, Guihua

2016-01-01

Quantum cryptography founded on the laws of physics could revolutionize the way in which communication information is protected. Significant progresses in long-distance quantum key distribution based on discrete variables have led to the secure quantum communication in real-world conditions being available. However, the alternative approach implemented with continuous variables has not yet reached the secure distance beyond 100 km. Here, we overcome the previous range limitation by controlling system excess noise and report such a long distance continuous-variable quantum key distribution experiment. Our result paves the road to the large-scale secure quantum communication with continuous variables and serves as a stepping stone in the quest for quantum network.

Long-distance continuous-variable quantum key distribution by controlling excess noise.

PubMed

Huang, Duan; Huang, Peng; Lin, Dakai; Zeng, Guihua

2016-01-13

Quantum cryptography founded on the laws of physics could revolutionize the way in which communication information is protected. Significant progresses in long-distance quantum key distribution based on discrete variables have led to the secure quantum communication in real-world conditions being available. However, the alternative approach implemented with continuous variables has not yet reached the secure distance beyond 100 km. Here, we overcome the previous range limitation by controlling system excess noise and report such a long distance continuous-variable quantum key distribution experiment. Our result paves the road to the large-scale secure quantum communication with continuous variables and serves as a stepping stone in the quest for quantum network.

Long-distance continuous-variable quantum key distribution by controlling excess noise

PubMed Central

Huang, Duan; Huang, Peng; Lin, Dakai; Zeng, Guihua

2016-01-01

Quantum cryptography founded on the laws of physics could revolutionize the way in which communication information is protected. Significant progresses in long-distance quantum key distribution based on discrete variables have led to the secure quantum communication in real-world conditions being available. However, the alternative approach implemented with continuous variables has not yet reached the secure distance beyond 100 km. Here, we overcome the previous range limitation by controlling system excess noise and report such a long distance continuous-variable quantum key distribution experiment. Our result paves the road to the large-scale secure quantum communication with continuous variables and serves as a stepping stone in the quest for quantum network. PMID:26758727

Quantitative Tomography for Continuous Variable Quantum Systems

NASA Astrophysics Data System (ADS)

Landon-Cardinal, Olivier; Govia, Luke C. G.; Clerk, Aashish A.

2018-03-01

We present a continuous variable tomography scheme that reconstructs the Husimi Q function (Wigner function) by Lagrange interpolation, using measurements of the Q function (Wigner function) at the Padua points, conjectured to be optimal sampling points for two dimensional reconstruction. Our approach drastically reduces the number of measurements required compared to using equidistant points on a regular grid, although reanalysis of such experiments is possible. The reconstruction algorithm produces a reconstructed function with exponentially decreasing error and quasilinear runtime in the number of Padua points. Moreover, using the interpolating polynomial of the Q function, we present a technique to directly estimate the density matrix elements of the continuous variable state, with only a linear propagation of input measurement error. Furthermore, we derive a state-independent analytical bound on this error, such that our estimate of the density matrix is accompanied by a measure of its uncertainty.

Path Entanglement of Continuous-Variable Quantum Microwaves

NASA Astrophysics Data System (ADS)

Menzel, E. P.; Deppe, F.; Eder, P.; Zhong, L.; Haeberlein, M.; Baust, A.; Hoffmann, E.; Marx, A.; Gross, R.; di Candia, R.; Solano, E.; Ballester, D.; Ihmig, M.; Inomata, K.; Yamamoto, T.; Nakamura, Y.

2013-03-01

Entanglement is a quantum mechanical phenomenon playing a key role in quantum communication and information processing protocols. Here, we report on frequency-degenerate entanglement between continuous-variable quantum microwaves propagating along two separated paths. In our experiment, we combine a squeezed and a vacuum state via a beam splitter. Overcoming the challenges imposed by the low photon energies in the microwave regime, we reconstruct the squeezed state and, independently from this, detect and quantify the produced entanglement via correlation measurements (E. P. Menzel et al., arXiv:1210.4413). Our work paves the way towards quantum communication and teleportation with continuous variables in the microwave regime. This work is supported by SFB 631, German Excellence Initiative via NIM, EU projects SOLID, CCQED and PROMISCE, MEXT Kakenhi ``Quantum Cybernetics'', JSPS FIRST Program, the NICT Commissioned Research, EPSRC EP/H050434/1, Basque Government IT472-10, and Spanish MICINN FIS2009-12773-C02-01.

Recent advances in microparticle continuous separation.

PubMed

Kersaudy-Kerhoas, M; Dhariwal, R; Desmulliez, M P Y

2008-03-01

Recent advances in microparticle separation in continuous flow are presented. It is intended for scientists in the field of separation science in biology, chemistry and microsystems engineering. Recent techniques of micron-sized particle separation within microsystems are described with emphasis on five different categories: optical, magnetic, fluidic-only, electrical and minor separation methods. Examples from the growing literature are explained with insights on separation efficiency and microengineering challenges. Current applications of the techniques are discussed.

A computer program for estimating the power-density spectrum of advanced continuous simulation language generated time histories

NASA Technical Reports Server (NTRS)

Dunn, H. J.

1981-01-01

A computer program for performing frequency analysis of time history data is presented. The program uses circular convolution and the fast Fourier transform to calculate power density spectrum (PDS) of time history data. The program interfaces with the advanced continuous simulation language (ACSL) so that a frequency analysis may be performed on ACSL generated simulation variables. An example of the calculation of the PDS of a Van de Pol oscillator is presented.

Optimality of Gaussian attacks in continuous-variable quantum cryptography.

PubMed

Navascués, Miguel; Grosshans, Frédéric; Acín, Antonio

2006-11-10

We analyze the asymptotic security of the family of Gaussian modulated quantum key distribution protocols for continuous-variables systems. We prove that the Gaussian unitary attack is optimal for all the considered bounds on the key rate when the first and second momenta of the canonical variables involved are known by the honest parties.

Impact of advanced monitoring variables on intraoperative clinical decision-making: an international survey.

PubMed

Joosten, Alexandre; Desebbe, Olivier; Suehiro, Koichi; Essiet, Mfonobong; Alexander, Brenton; Ricks, Cameron; Rinehart, Joseph; Faraoni, David; Cecconi, Maurizio; Van der Linden, Philippe; Cannesson, Maxime

2017-02-01

To assess the relationship between the addition of advanced monitoring variables and changes in clinical decision-making. A 15-questions survey was anonymously emailed to international experts and physician members of five anesthesia societies which focused on assessing treatment decisions of clinicians during three realistic clinical scenarios measured at two distinct time points. The first is when typical case information and basic monitoring (T1) were provided, and then once again after the addition of advanced monitoring variables (T2). We hypothesized that the addition of advanced variables would increase the incidence of an optimal therapeutic decision (a priori defined as the answer with the highest percentage of expert agreement) and decrease the variability among the physician's suggested treatments. The survey was completed by 18 experts and 839 physicians. Overall, adding advanced monitoring did not significantly increase physician response accuracy, with the least substantial changes noted on questions related to volume expansion or vasopressor administration. Moreover, advanced monitoring data did not significantly decrease the high level of initial practice variability in physician suggested treatments (P = 0.13), in contrast to the low variability observed within the expert group (P = 0.039). Additionally, 5-10 years of practice (P < 0.0001) and a cardiovascular subspecialty (P = 0.048) were both physician characteristics associated with a higher rate of optimal therapeutic decisions. The addition of advanced variables was of limited benefit for most physicians, further indicating the need for more in depth education on the clinical value and technical understanding of such variables.

Coherent communication with continuous quantum variables

NASA Astrophysics Data System (ADS)

Wilde, Mark M.; Krovi, Hari; Brun, Todd A.

2007-06-01

The coherent bit (cobit) channel is a resource intermediate between classical and quantum communication. It produces coherent versions of teleportation and superdense coding. We extend the cobit channel to continuous variables by providing a definition of the coherent nat (conat) channel. We construct several coherent protocols that use both a position-quadrature and a momentum-quadrature conat channel with finite squeezing. Finally, we show that the quality of squeezing diminishes through successive compositions of coherent teleportation and superdense coding.

Mixture Factor Analysis for Approximating a Nonnormally Distributed Continuous Latent Factor with Continuous and Dichotomous Observed Variables

ERIC Educational Resources Information Center

Wall, Melanie M.; Guo, Jia; Amemiya, Yasuo

2012-01-01

Mixture factor analysis is examined as a means of flexibly estimating nonnormally distributed continuous latent factors in the presence of both continuous and dichotomous observed variables. A simulation study compares mixture factor analysis with normal maximum likelihood (ML) latent factor modeling. Different results emerge for continuous versus…

Robustness of quantum key distribution with discrete and continuous variables to channel noise

NASA Astrophysics Data System (ADS)

Lasota, Mikołaj; Filip, Radim; Usenko, Vladyslav C.

2017-06-01

We study the robustness of quantum key distribution protocols using discrete or continuous variables to the channel noise. We introduce the model of such noise based on coupling of the signal to a thermal reservoir, typical for continuous-variable quantum key distribution, to the discrete-variable case. Then we perform a comparison of the bounds on the tolerable channel noise between these two kinds of protocols using the same noise parametrization, in the case of implementation which is perfect otherwise. Obtained results show that continuous-variable protocols can exhibit similar robustness to the channel noise when the transmittance of the channel is relatively high. However, for strong loss discrete-variable protocols are superior and can overcome even the infinite-squeezing continuous-variable protocol while using limited nonclassical resources. The requirement on the probability of a single-photon production which would have to be fulfilled by a practical source of photons in order to demonstrate such superiority is feasible thanks to the recent rapid development in this field.

Secure quantum key distribution using continuous variables of single photons.

PubMed

Zhang, Lijian; Silberhorn, Christine; Walmsley, Ian A

2008-03-21

We analyze the distribution of secure keys using quantum cryptography based on the continuous variable degree of freedom of entangled photon pairs. We derive the information capacity of a scheme based on the spatial entanglement of photons from a realistic source, and show that the standard measures of security known for quadrature-based continuous variable quantum cryptography (CV-QKD) are inadequate. A specific simple eavesdropping attack is analyzed to illuminate how secret information may be distilled well beyond the bounds of the usual CV-QKD measures.

Analysis on electronic control unit of continuously variable transmission

NASA Astrophysics Data System (ADS)

Cao, Shuanggui

Continuously variable transmission system can ensure that the engine work along the line of best fuel economy, improve fuel economy, save fuel and reduce harmful gas emissions. At the same time, continuously variable transmission allows the vehicle speed is more smooth and improves the ride comfort. Although the CVT technology has made great development, but there are many shortcomings in the CVT. The CVT system of ordinary vehicles now is still low efficiency, poor starting performance, low transmission power, and is not ideal controlling, high cost and other issues. Therefore, many scholars began to study some new type of continuously variable transmission. The transmission system with electronic systems control can achieve automatic control of power transmission, give full play to the characteristics of the engine to achieve optimal control of powertrain, so the vehicle is always traveling around the best condition. Electronic control unit is composed of the core processor, input and output circuit module and other auxiliary circuit module. Input module collects and process many signals sent by sensor and , such as throttle angle, brake signals, engine speed signal, speed signal of input and output shaft of transmission, manual shift signals, mode selection signals, gear position signal and the speed ratio signal, so as to provide its corresponding processing for the controller core.

Continuous-variable quantum teleportation with non-Gaussian resources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dell'Anno, F.; Dipartimento di Fisica, Universita degli Studi di Salerno, Via S. Allende, I-84081 Baronissi; CNR-INFM Coherentia, Napoli, Italy and CNISM Unita di Salerno and INFN Sezione di Napoli, Gruppo Collegato di Salerno, Baronissi

2007-08-15

We investigate continuous variable quantum teleportation using non-Gaussian states of the radiation field as entangled resources. We compare the performance of different classes of degaussified resources, including two-mode photon-added and two-mode photon-subtracted squeezed states. We then introduce a class of two-mode squeezed Bell-like states with one-parameter dependence for optimization. These states interpolate between and include as subcases different classes of degaussified resources. We show that optimized squeezed Bell-like resources yield a remarkable improvement in the fidelity of teleportation both for coherent and nonclassical input states. The investigation reveals that the optimal non-Gaussian resources for continuous variable teleportation are those thatmore » most closely realize the simultaneous maximization of the content of entanglement, the degree of affinity with the two-mode squeezed vacuum, and the, suitably measured, amount of non-Gaussianity.« less

A Geometrical Framework for Covariance Matrices of Continuous and Categorical Variables

ERIC Educational Resources Information Center

Vernizzi, Graziano; Nakai, Miki

2015-01-01

It is well known that a categorical random variable can be represented geometrically by a simplex. Accordingly, several measures of association between categorical variables have been proposed and discussed in the literature. Moreover, the standard definitions of covariance and correlation coefficient for continuous random variables have been…

Compact continuous-variable entanglement distillation.

PubMed

Datta, Animesh; Zhang, Lijian; Nunn, Joshua; Langford, Nathan K; Feito, Alvaro; Plenio, Martin B; Walmsley, Ian A

2012-02-10

We introduce a new scheme for continuous-variable entanglement distillation that requires only linear temporal and constant physical or spatial resources. Distillation is the process by which high-quality entanglement may be distributed between distant nodes of a network in the unavoidable presence of decoherence. The known versions of this protocol scale exponentially in space and doubly exponentially in time. Our optimal scheme therefore provides exponential improvements over existing protocols. It uses a fixed-resource module-an entanglement distillery-comprising only four quantum memories of at most 50% storage efficiency and allowing a feasible experimental implementation. Tangible quantum advantages are obtainable by using existing off-resonant Raman quantum memories outside their conventional role of storage.

Practical limitation for continuous-variable quantum cryptography using coherent States.

PubMed

Namiki, Ryo; Hirano, Takuya

2004-03-19

In this Letter, first, we investigate the security of a continuous-variable quantum cryptographic scheme with a postselection process against individual beam splitting attack. It is shown that the scheme can be secure in the presence of the transmission loss owing to the postselection. Second, we provide a loss limit for continuous-variable quantum cryptography using coherent states taking into account excess Gaussian noise on quadrature distribution. Since the excess noise is reduced by the loss mechanism, a realistic intercept-resend attack which makes a Gaussian mixture of coherent states gives a loss limit in the presence of any excess Gaussian noise.

Generalized Processing Tree Models: Jointly Modeling Discrete and Continuous Variables.

PubMed

Heck, Daniel W; Erdfelder, Edgar; Kieslich, Pascal J

2018-05-24

Multinomial processing tree models assume that discrete cognitive states determine observed response frequencies. Generalized processing tree (GPT) models extend this conceptual framework to continuous variables such as response times, process-tracing measures, or neurophysiological variables. GPT models assume finite-mixture distributions, with weights determined by a processing tree structure, and continuous components modeled by parameterized distributions such as Gaussians with separate or shared parameters across states. We discuss identifiability, parameter estimation, model testing, a modeling syntax, and the improved precision of GPT estimates. Finally, a GPT version of the feature comparison model of semantic categorization is applied to computer-mouse trajectories.

Continuous-variable protocol for oblivious transfer in the noisy-storage model.

PubMed

Furrer, Fabian; Gehring, Tobias; Schaffner, Christian; Pacher, Christoph; Schnabel, Roman; Wehner, Stephanie

2018-04-13

Cryptographic protocols are the backbone of our information society. This includes two-party protocols which offer protection against distrustful players. Such protocols can be built from a basic primitive called oblivious transfer. We present and experimentally demonstrate here a quantum protocol for oblivious transfer for optical continuous-variable systems, and prove its security in the noisy-storage model. This model allows us to establish security by sending more quantum signals than an attacker can reliably store during the protocol. The security proof is based on uncertainty relations which we derive for continuous-variable systems, that differ from the ones used in quantum key distribution. We experimentally demonstrate in a proof-of-principle experiment the proposed oblivious transfer protocol for various channel losses by using entangled two-mode squeezed states measured with balanced homodyne detection. Our work enables the implementation of arbitrary two-party quantum cryptographic protocols with continuous-variable communication systems.

Teleportation-based continuous variable quantum cryptography

NASA Astrophysics Data System (ADS)

Luiz, F. S.; Rigolin, Gustavo

2017-03-01

We present a continuous variable (CV) quantum key distribution (QKD) scheme based on the CV quantum teleportation of coherent states that yields a raw secret key made up of discrete variables for both Alice and Bob. This protocol preserves the efficient detection schemes of current CV technology (no single-photon detection techniques) and, at the same time, has efficient error correction and privacy amplification schemes due to the binary modulation of the key. We show that for a certain type of incoherent attack, it is secure for almost any value of the transmittance of the optical line used by Alice to share entangled two-mode squeezed states with Bob (no 3 dB or 50% loss limitation characteristic of beam splitting attacks). The present CVQKD protocol works deterministically (no postselection needed) with efficient direct reconciliation techniques (no reverse reconciliation) in order to generate a secure key and beyond the 50% loss case at the incoherent attack level.

Gapped two-body Hamiltonian for continuous-variable quantum computation.

PubMed

Aolita, Leandro; Roncaglia, Augusto J; Ferraro, Alessandro; Acín, Antonio

2011-03-04

We introduce a family of Hamiltonian systems for measurement-based quantum computation with continuous variables. The Hamiltonians (i) are quadratic, and therefore two body, (ii) are of short range, (iii) are frustration-free, and (iv) possess a constant energy gap proportional to the squared inverse of the squeezing. Their ground states are the celebrated Gaussian graph states, which are universal resources for quantum computation in the limit of infinite squeezing. These Hamiltonians constitute the basic ingredient for the adiabatic preparation of graph states and thus open new venues for the physical realization of continuous-variable quantum computing beyond the standard optical approaches. We characterize the correlations in these systems at thermal equilibrium. In particular, we prove that the correlations across any multipartition are contained exactly in its boundary, automatically yielding a correlation area law.

Determination of continuous variable entanglement by purity measurements.

PubMed

Adesso, Gerardo; Serafini, Alessio; Illuminati, Fabrizio

2004-02-27

We classify the entanglement of two-mode Gaussian states according to their degree of total and partial mixedness. We derive exact bounds that determine maximally and minimally entangled states for fixed global and marginal purities. This characterization allows for an experimentally reliable estimate of continuous variable entanglement based on measurements of purity.

Advanced supersonic propulsion study, phases 3 and 4. [variable cycle engines

NASA Technical Reports Server (NTRS)

Allan, R. D.; Joy, W.

1977-01-01

An evaluation of various advanced propulsion concepts for supersonic cruise aircraft resulted in the identification of the double-bypass variable cycle engine as the most promising concept. This engine design utilizes special variable geometry components and an annular exhaust nozzle to provide high take-off thrust and low jet noise. The engine also provides good performance at both supersonic cruise and subsonic cruise. Emission characteristics are excellent. The advanced technology double-bypass variable cycle engine offers an improvement in aircraft range performance relative to earlier supersonic jet engine designs and yet at a lower level of engine noise. Research and technology programs required in certain design areas for this engine concept to realize its potential benefits include refined parametric analysis of selected variable cycle engines, screening of additional unconventional concepts, and engine preliminary design studies. Required critical technology programs are summarized.

Operational quantification of continuous-variable correlations.

PubMed

Rodó, Carles; Adesso, Gerardo; Sanpera, Anna

2008-03-21

We quantify correlations (quantum and/or classical) between two continuous-variable modes as the maximal number of correlated bits extracted via local quadrature measurements. On Gaussian states, such "bit quadrature correlations" majorize entanglement, reducing to an entanglement monotone for pure states. For non-Gaussian states, such as photonic Bell states, photon-subtracted states, and mixtures of Gaussian states, the bit correlations are shown to be a monotonic function of the negativity. This quantification yields a feasible, operational way to measure non-Gaussian entanglement in current experiments by means of direct homodyne detection, without a complete state tomography.

Gate sequence for continuous variable one-way quantum computation

PubMed Central

Su, Xiaolong; Hao, Shuhong; Deng, Xiaowei; Ma, Lingyu; Wang, Meihong; Jia, Xiaojun; Xie, Changde; Peng, Kunchi

2013-01-01

Measurement-based one-way quantum computation using cluster states as resources provides an efficient model to perform computation and information processing of quantum codes. Arbitrary Gaussian quantum computation can be implemented sufficiently by long single-mode and two-mode gate sequences. However, continuous variable gate sequences have not been realized so far due to an absence of cluster states larger than four submodes. Here we present the first continuous variable gate sequence consisting of a single-mode squeezing gate and a two-mode controlled-phase gate based on a six-mode cluster state. The quantum property of this gate sequence is confirmed by the fidelities and the quantum entanglement of two output modes, which depend on both the squeezing and controlled-phase gates. The experiment demonstrates the feasibility of implementing Gaussian quantum computation by means of accessible gate sequences.

High-speed limnology: using advanced sensors to investigate spatial variability in biogeochemistry and hydrology.

PubMed

Crawford, John T; Loken, Luke C; Casson, Nora J; Smith, Colin; Stone, Amanda G; Winslow, Luke A

2015-01-06

Advanced sensor technology is widely used in aquatic monitoring and research. Most applications focus on temporal variability, whereas spatial variability has been challenging to document. We assess the capability of water chemistry sensors embedded in a high-speed water intake system to document spatial variability. This new sensor platform continuously samples surface water at a range of speeds (0 to >45 km h(-1)) resulting in high-density, mesoscale spatial data. These novel observations reveal previously unknown variability in physical, chemical, and biological factors in streams, rivers, and lakes. By combining multiple sensors into one platform, we were able to detect terrestrial-aquatic hydrologic connections in a small dystrophic lake, to infer the role of main-channel vs backwater nutrient processing in a large river and to detect sharp chemical changes across aquatic ecosystem boundaries in a stream/lake complex. Spatial sensor data were verified in our examples by comparing with standard lab-based measurements of selected variables. Spatial fDOM data showed strong correlation with wet chemistry measurements of DOC, and optical NO3 concentrations were highly correlated with lab-based measurements. High-frequency spatial data similar to our examples could be used to further understand aquatic biogeochemical fluxes, ecological patterns, and ecosystem processes, and will both inform and benefit from fixed-site data.

High-speed limnology: Using advanced sensors to investigate spatial variability in biogeochemistry and hydrology

USGS Publications Warehouse

Crawford, John T.; Loken, Luke C.; Casson, Nora J.; Smith, Collin; Stone, Amanda G.; Winslow, Luke A.

2015-01-01

Advanced sensor technology is widely used in aquatic monitoring and research. Most applications focus on temporal variability, whereas spatial variability has been challenging to document. We assess the capability of water chemistry sensors embedded in a high-speed water intake system to document spatial variability. This new sensor platform continuously samples surface water at a range of speeds (0 to >45 km h–1) resulting in high-density, mesoscale spatial data. These novel observations reveal previously unknown variability in physical, chemical, and biological factors in streams, rivers, and lakes. By combining multiple sensors into one platform, we were able to detect terrestrial–aquatic hydrologic connections in a small dystrophic lake, to infer the role of main-channel vs backwater nutrient processing in a large river and to detect sharp chemical changes across aquatic ecosystem boundaries in a stream/lake complex. Spatial sensor data were verified in our examples by comparing with standard lab-based measurements of selected variables. Spatial fDOM data showed strong correlation with wet chemistry measurements of DOC, and optical NO3 concentrations were highly correlated with lab-based measurements. High-frequency spatial data similar to our examples could be used to further understand aquatic biogeochemical fluxes, ecological patterns, and ecosystem processes, and will both inform and benefit from fixed-site data.

Finite-size analysis of a continuous-variable quantum key distribution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leverrier, Anthony; Grosshans, Frederic; Grangier, Philippe

2010-06-15

The goal of this paper is to extend the framework of finite-size analysis recently developed for quantum key distribution to continuous-variable protocols. We do not solve this problem completely here, and we mainly consider the finite-size effects on the parameter estimation procedure. Despite the fact that some questions are left open, we are able to give an estimation of the secret key rate for protocols which do not contain a postselection procedure. As expected, these results are significantly more pessimistic than those obtained in the asymptotic regime. However, we show that recent continuous-variable protocols are able to provide fully securemore » secret keys in the finite-size scenario, over distances larger than 50 km.« less

Equivalence between entanglement and the optimal fidelity of continuous variable teleportation.

PubMed

Adesso, Gerardo; Illuminati, Fabrizio

2005-10-07

We devise the optimal form of Gaussian resource states enabling continuous-variable teleportation with maximal fidelity. We show that a nonclassical optimal fidelity of N-user teleportation networks is necessary and sufficient for N-party entangled Gaussian resources, yielding an estimator of multipartite entanglement. The entanglement of teleportation is equivalent to the entanglement of formation in a two-user protocol, and to the localizable entanglement in a multiuser one. Finally, we show that the continuous-variable tangle, quantifying entanglement sharing in three-mode Gaussian states, is defined operationally in terms of the optimal fidelity of a tripartite teleportation network.

Broadband continuous-variable entanglement source using a chirped poling nonlinear crystal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, J. S.; Sun, L.; Yu, X. Q.

2010-01-15

Aperiodically poled nonlinear crystal can be used as a broadband continuous-variable entanglement source and has strong stability under perturbations. We study the conversion dynamics of the sum-frequency generation and the quantum correlation of the two pump fields in a chirped-structure nonlinear crystal using the quantum stochastic method. The results show that there exists a frequency window for the pumps where two optical fields can perform efficient upconversion. The two pump fields are demonstrated to be entangled in the window and the chirped-structure crystal can be used as a continuous-variable entanglement source with a broad response bandwidth.

Continuous operation of four-state continuous-variable quantum key distribution system

NASA Astrophysics Data System (ADS)

Matsubara, Takuto; Ono, Motoharu; Oguri, Yusuke; Ichikawa, Tsubasa; Hirano, Takuya; Kasai, Kenta; Matsumoto, Ryutaroh; Tsurumaru, Toyohiro

2016-10-01

We report on the development of continuous-variable quantum key distribution (CV-QKD) system that are based on discrete quadrature amplitude modulation (QAM) and homodyne detection of coherent states of light. We use a pulsed light source whose wavelength is 1550 nm and repetition rate is 10 MHz. The CV-QKD system can continuously generate secret key which is secure against entangling cloner attack. Key generation rate is 50 kbps when the quantum channel is a 10 km optical fiber. The CV-QKD system we have developed utilizes the four-state and post-selection protocol [T. Hirano, et al., Phys. Rev. A 68, 042331 (2003).]; Alice randomly sends one of four states {|+/-α⟩,|+/-𝑖α⟩}, and Bob randomly performs x- or p- measurement by homodyne detection. A commercially available balanced receiver is used to realize shot-noise-limited pulsed homodyne detection. GPU cards are used to accelerate the software-based post-processing. We use a non-binary LDPC code for error correction (reverse reconciliation) and the Toeplitz matrix multiplication for privacy amplification.

Teleportation of Two-Mode Quantum State of Continuous Variables

NASA Astrophysics Data System (ADS)

Song, Tong-Qiang

2004-03-01

Using two Einstein-Podolsky-Rosen pair eigenstates |η> as quantum channels, we study the teleportation of two-mode quantum state of continuous variables. The project supported by Natural Science Foundation of Zhejiang Province of China and Open Foundation of Laboratory of High-Intensity Optics, Shanghai Institute of Optics and Fine Mechanics

The Integration of Continuous and Discrete Latent Variable Models: Potential Problems and Promising Opportunities

ERIC Educational Resources Information Center

Bauer, Daniel J.; Curran, Patrick J.

2004-01-01

Structural equation mixture modeling (SEMM) integrates continuous and discrete latent variable models. Drawing on prior research on the relationships between continuous and discrete latent variable models, the authors identify 3 conditions that may lead to the estimation of spurious latent classes in SEMM: misspecification of the structural model,…

How to decompose arbitrary continuous-variable quantum operations.

PubMed

Sefi, Seckin; van Loock, Peter

2011-10-21

We present a general, systematic, and efficient method for decomposing any given exponential operator of bosonic mode operators, describing an arbitrary multimode Hamiltonian evolution, into a set of universal unitary gates. Although our approach is mainly oriented towards continuous-variable quantum computation, it may be used more generally whenever quantum states are to be transformed deterministically, e.g., in quantum control, discrete-variable quantum computation, or Hamiltonian simulation. We illustrate our scheme by presenting decompositions for various nonlinear Hamiltonians including quartic Kerr interactions. Finally, we conclude with two potential experiments utilizing offline-prepared optical cubic states and homodyne detections, in which quantum information is processed optically or in an atomic memory using quadratic light-atom interactions. © 2011 American Physical Society

Continuous-variable quantum probes for structured environments

NASA Astrophysics Data System (ADS)

Bina, Matteo; Grasselli, Federico; Paris, Matteo G. A.

2018-01-01

We address parameter estimation for structured environments and suggest an effective estimation scheme based on continuous-variables quantum probes. In particular, we investigate the use of a single bosonic mode as a probe for Ohmic reservoirs, and obtain the ultimate quantum limits to the precise estimation of their cutoff frequency. We assume the probe prepared in a Gaussian state and determine the optimal working regime, i.e., the conditions for the maximization of the quantum Fisher information in terms of the initial preparation, the reservoir temperature, and the interaction time. Upon investigating the Fisher information of feasible measurements, we arrive at a remarkable simple result: homodyne detection of canonical variables allows one to achieve the ultimate quantum limit to precision under suitable, mild, conditions. Finally, upon exploiting a perturbative approach, we find the invariant sweet spots of the (tunable) characteristic frequency of the probe, able to drive the probe towards the optimal working regime.

Continuous-variable teleportation of a negative Wigner function

NASA Astrophysics Data System (ADS)

Mišta, Ladislav, Jr.; Filip, Radim; Furusawa, Akira

2010-07-01

Teleportation is a basic primitive for quantum communication and quantum computing. We address the problem of continuous-variable (unconditional and conditional) teleportation of a pure single-photon state and a mixed attenuated single-photon state generally in a nonunity-gain regime. Our figure of merit is the maximum negativity of the Wigner function, which demonstrates a highly nonclassical feature of the teleported state. We find that the negativity of the Wigner function of the single-photon state can be unconditionally teleported for an arbitrarily weak squeezed state used to create the entangled state shared in teleportation. In contrast, for the attenuated single-photon state there is a strict threshold squeezing one has to surpass to successfully teleport the negativity of its Wigner function. The conditional teleportation allows one to approach perfect transmission of the single photon for an arbitrarily low squeezing at a cost of decrease of the success rate. In contrast, for the attenuated single photon state, conditional teleportation cannot overcome the squeezing threshold of the unconditional teleportation and it approaches negativity of the input state only if the squeezing increases simultaneously. However, as soon as the threshold squeezing is surpassed, conditional teleportation still pronouncedly outperforms the unconditional one. The main consequences for quantum communication and quantum computing with continuous variables are discussed.

Continuously variable focal length lens

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, Bernhard W; Chollet, Matthieu C

2013-12-17

A material preferably in crystal form having a low atomic number such as beryllium (Z=4) provides for the focusing of x-rays in a continuously variable manner. The material is provided with plural spaced curvilinear, optically matched slots and/or recesses through which an x-ray beam is directed. The focal length of the material may be decreased or increased by increasing or decreasing, respectively, the number of slots (or recesses) through which the x-ray beam is directed, while fine tuning of the focal length is accomplished by rotation of the material so as to change the path length of the x-ray beammore » through the aligned cylindrical slows. X-ray analysis of a fixed point in a solid material may be performed by scanning the energy of the x-ray beam while rotating the material to maintain the beam's focal point at a fixed point in the specimen undergoing analysis.« less

Breaking Gaussian incompatibility on continuous variable quantum systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heinosaari, Teiko, E-mail: teiko.heinosaari@utu.fi; Kiukas, Jukka, E-mail: jukka.kiukas@aber.ac.uk; Schultz, Jussi, E-mail: jussi.schultz@gmail.com

2015-08-15

We characterise Gaussian quantum channels that are Gaussian incompatibility breaking, that is, transform every set of Gaussian measurements into a set obtainable from a joint Gaussian observable via Gaussian postprocessing. Such channels represent local noise which renders measurements useless for Gaussian EPR-steering, providing the appropriate generalisation of entanglement breaking channels for this scenario. Understanding the structure of Gaussian incompatibility breaking channels contributes to the resource theory of noisy continuous variable quantum information protocols.

CADDIS Volume 4. Data Analysis: Advanced Analyses - Controlling for Natural Variability

EPA Pesticide Factsheets

Methods for controlling natural variability, predicting environmental conditions from biological observations method, biological trait data, species sensitivity distributions, propensity scores, Advanced Analyses of Data Analysis references.

Criteria for genuine N -partite continuous-variable entanglement and Einstein-Podolsky-Rosen steering

NASA Astrophysics Data System (ADS)

Teh, R. Y.; Reid, M. D.

2014-12-01

Following previous work, we distinguish between genuine N -partite entanglement and full N -partite inseparability. Accordingly, we derive criteria to detect genuine multipartite entanglement using continuous-variable (position and momentum) measurements. Our criteria are similar but different to those based on the van Loock-Furusawa inequalities, which detect full N -partite inseparability. We explain how the criteria can be used to detect the genuine N -partite entanglement of continuous variable states generated from squeezed and vacuum state inputs, including the continuous-variable Greenberger-Horne-Zeilinger state, with explicit predictions for up to N =9 . This makes our work accessible to experiment. For N =3 , we also present criteria for tripartite Einstein-Podolsky-Rosen (EPR) steering. These criteria provide a means to demonstrate a genuine three-party EPR paradox, in which any single party is steerable by the remaining two parties.

Self-referenced continuous-variable quantum key distribution

DOEpatents

Soh, Daniel B. S.; Sarovar, Mohan; Camacho, Ryan

2017-01-24

Various technologies for continuous-variable quantum key distribution without transmitting a transmitter's local oscillator are described herein. A receiver on an optical transmission channel uses an oscillator signal generated by a light source at the receiver's location to perform interferometric detection on received signals. An optical reference pulse is sent by the transmitter on the transmission channel and the receiver computes a phase offset of the transmission based on quadrature measurements of the reference pulse. The receiver can then compensate for the phase offset between the transmitter's reference and the receiver's reference when measuring quadratures of received data pulses.

Continuous-variable teleportation of a negative Wigner function

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mista, Ladislav Jr.; Filip, Radim; Furusawa, Akira

2010-07-15

Teleportation is a basic primitive for quantum communication and quantum computing. We address the problem of continuous-variable (unconditional and conditional) teleportation of a pure single-photon state and a mixed attenuated single-photon state generally in a nonunity-gain regime. Our figure of merit is the maximum negativity of the Wigner function, which demonstrates a highly nonclassical feature of the teleported state. We find that the negativity of the Wigner function of the single-photon state can be unconditionally teleported for an arbitrarily weak squeezed state used to create the entangled state shared in teleportation. In contrast, for the attenuated single-photon state there ismore » a strict threshold squeezing one has to surpass to successfully teleport the negativity of its Wigner function. The conditional teleportation allows one to approach perfect transmission of the single photon for an arbitrarily low squeezing at a cost of decrease of the success rate. In contrast, for the attenuated single photon state, conditional teleportation cannot overcome the squeezing threshold of the unconditional teleportation and it approaches negativity of the input state only if the squeezing increases simultaneously. However, as soon as the threshold squeezing is surpassed, conditional teleportation still pronouncedly outperforms the unconditional one. The main consequences for quantum communication and quantum computing with continuous variables are discussed.« less

Interesting examples of supervised continuous variable systems

NASA Technical Reports Server (NTRS)

Chase, Christopher; Serrano, Joe; Ramadge, Peter

1990-01-01

The authors analyze two simple deterministic flow models for multiple buffer servers which are examples of the supervision of continuous variable systems by a discrete controller. These systems exhibit what may be regarded as the two extremes of complexity of the closed loop behavior: one is eventually periodic, the other is chaotic. The first example exhibits chaotic behavior that could be characterized statistically. The dual system, the switched server system, exhibits very predictable behavior, which is modeled by a finite state automaton. This research has application to multimodal discrete time systems where the controller can choose from a set of transition maps to implement.

Revisiting relationships between sex-related variables and continuation in counseling.

PubMed

Hatchett, Gregory T; Park, Heather L

2004-04-01

This study examined the relationships between three sex-related variables (client sex, therapist sex, and dyad matching on sex) and continuation in counseling. 245 college students who were clients at three university counseling centers participated. Consistent with previous studies, women comprised 68.2% of the clients seeking services at these counseling centers. Clients' sex was significantly related to counseling duration, explaining 2.2% of the common variance. Female clients, on the average, attended 1.8 more sessions than male clients. However, neither the therapists' sex nor dyad matching on sex was significantly related to the duration of counseling. None of the sex-related variables correlated with premature termination of counseling. The results have implications for providing counseling and outreach services to male students. Despite relatively equivalent rates in the incidence of mental health problems, female students continue to comprise the majority of clients. Therefore, university counseling centers need to communicate their services better to male students in need of mental health services.

Different operational meanings of continuous variable Gaussian entanglement criteria and Bell inequalities

NASA Astrophysics Data System (ADS)

Buono, D.; Nocerino, G.; Solimeno, S.; Porzio, A.

2014-07-01

Entanglement, one of the most intriguing aspects of quantum mechanics, marks itself into different features of quantum states. For this reason different criteria can be used for verifying entanglement. In this paper we review some of the entanglement criteria casted for continuous variable states and link them to peculiar aspects of the original debate on the famous Einstein-Podolsky-Rosen (EPR) paradox. We also provide a useful expression for valuating Bell-type non-locality on Gaussian states. We also present the experimental measurement of a particular realization of the Bell operator over continuous variable entangled states produced by a sub-threshold type-II optical parametric oscillators (OPOs).

Continuous-variable quantum computation with spatial degrees of freedom of photons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tasca, D. S.; Gomes, R. M.; Toscano, F.

2011-05-15

We discuss the use of the transverse spatial degrees of freedom of photons propagating in the paraxial approximation for continuous-variable information processing. Given the wide variety of linear optical devices available, a diverse range of operations can be performed on the spatial degrees of freedom of single photons. Here we show how to implement a set of continuous quantum logic gates which allow for universal quantum computation. In contrast with the usual quadratures of the electromagnetic field, the entire set of single-photon gates for spatial degrees of freedom does not require optical nonlinearity and, in principle, can be performed withmore » a single device: the spatial light modulator. Nevertheless, nonlinear optical processes, such as four-wave mixing, are needed in the implementation of two-photon gates. The efficiency of these gates is at present very low; however, small-scale investigations of continuous-variable quantum computation are within the reach of current technology. In this regard, we show how novel cluster states for one-way quantum computing can be produced using spontaneous parametric down-conversion.« less

Quantum repeaters using continuous-variable teleportation

NASA Astrophysics Data System (ADS)

Dias, Josephine; Ralph, T. C.

2017-02-01

Quantum optical states are fragile and can become corrupted when passed through a lossy communication channel. Unlike for classical signals, optical amplifiers cannot be used to recover quantum signals. Quantum repeaters have been proposed as a way of reducing errors and hence increasing the range of quantum communications. Current protocols target specific discrete encodings, for example quantum bits encoded on the polarization of single photons. We introduce a more general approach that can reduce the effect of loss on any quantum optical encoding, including those based on continuous variables such as the field amplitudes. We show that in principle the protocol incurs a resource cost that scales polynomially with distance. We analyze the simplest implementation and find that while its range is limited it can still achieve useful improvements in the distance over which quantum entanglement of field amplitudes can be distributed.

Quantum error correction of continuous-variable states against Gaussian noise

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ralph, T. C.

2011-08-15

We describe a continuous-variable error correction protocol that can correct the Gaussian noise induced by linear loss on Gaussian states. The protocol can be implemented using linear optics and photon counting. We explore the theoretical bounds of the protocol as well as the expected performance given current knowledge and technology.

Continued advancement of the programming language HAL to an operational status

NASA Technical Reports Server (NTRS)

1971-01-01

The continued advancement of the programming language HAL to operational status is reported. It is demonstrated that the compiler itself can be written in HAL. A HAL-in-HAL experiment proves conclusively that HAL can be used successfully as a compiler implementation tool.

Continuous-variable quantum key distribution with Gaussian source noise

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shen Yujie; Peng Xiang; Yang Jian

2011-05-15

Source noise affects the security of continuous-variable quantum key distribution (CV QKD) and is difficult to analyze. We propose a model to characterize Gaussian source noise through introducing a neutral party (Fred) who induces the noise with a general unitary transformation. Without knowing Fred's exact state, we derive the security bounds for both reverse and direct reconciliations and show that the bound for reverse reconciliation is tight.

Measures of Quantum Synchronization in Continuous Variable Systems

NASA Astrophysics Data System (ADS)

Mari, A.; Farace, A.; Didier, N.; Giovannetti, V.; Fazio, R.

2013-09-01

We introduce and characterize two different measures which quantify the level of synchronization of coupled continuous variable quantum systems. The two measures allow us to extend to the quantum domain the notions of complete and phase synchronization. The Heisenberg principle sets a universal bound to complete synchronization. The measure of phase synchronization is, in principle, unbounded; however, in the absence of quantum resources (e.g., squeezing) the synchronization level is bounded below a certain threshold. We elucidate some interesting connections between entanglement and synchronization and, finally, discuss an application based on quantum optomechanical systems.

Measures of quantum synchronization in continuous variable systems.

PubMed

Mari, A; Farace, A; Didier, N; Giovannetti, V; Fazio, R

2013-09-06

We introduce and characterize two different measures which quantify the level of synchronization of coupled continuous variable quantum systems. The two measures allow us to extend to the quantum domain the notions of complete and phase synchronization. The Heisenberg principle sets a universal bound to complete synchronization. The measure of phase synchronization is, in principle, unbounded; however, in the absence of quantum resources (e.g., squeezing) the synchronization level is bounded below a certain threshold. We elucidate some interesting connections between entanglement and synchronization and, finally, discuss an application based on quantum optomechanical systems.

Quantum correlations for bipartite continuous-variable systems

NASA Astrophysics Data System (ADS)

Ma, Ruifen; Hou, Jinchuan; Qi, Xiaofei; Wang, Yangyang

2018-04-01

Two quantum correlations Q and Q_P for (m+n)-mode continuous-variable systems are introduced in terms of average distance between the reduced states under the local Gaussian positive operator-valued measurements, and analytical formulas of these quantum correlations for bipartite Gaussian states are provided. It is shown that the product states do not contain these quantum correlations, and conversely, all (m+n)-mode Gaussian states with zero quantum correlations are product states. Generally, Q≥ Q_{P}, but for the symmetric two-mode squeezed thermal states, these quantum correlations are the same and a computable formula is given. In addition, Q is compared with Gaussian geometric discord for symmetric squeezed thermal states.

Pharmacists' Interest in and Commitment to Obtaining an Advanced Pharmacy Degree through Continuing Education.

ERIC Educational Resources Information Center

Riley, David A.

1986-01-01

Describes results of a survey of all West Virginia pharmacists concerning their views on continuing education and advanced pharmacy degrees. Conclusions indicate a small percentage of pharmacists are interested in a higher degree via continuing education. (Author/CT)

Composable security proof for continuous-variable quantum key distribution with coherent States.

PubMed

Leverrier, Anthony

2015-02-20

We give the first composable security proof for continuous-variable quantum key distribution with coherent states against collective attacks. Crucially, in the limit of large blocks the secret key rate converges to the usual value computed from the Holevo bound. Combining our proof with either the de Finetti theorem or the postselection technique then shows the security of the protocol against general attacks, thereby confirming the long-standing conjecture that Gaussian attacks are optimal asymptotically in the composable security framework. We expect that our parameter estimation procedure, which does not rely on any assumption about the quantum state being measured, will find applications elsewhere, for instance, for the reliable quantification of continuous-variable entanglement in finite-size settings.

Improving quality and patient satisfaction in a pediatric resident continuity clinic through advanced access scheduling.

PubMed

Tuli, Sanjeev Y; Thompson, Lindsay A; Ryan, Kathleen A; Srinivas, Ganga L; Fillipps, Donald J; Young, Christopher M; Tuli, Sonal S

2010-06-01

To evaluate the impact of advanced access scheduling in a pediatric residency clinic on resident and patient satisfaction, medical education, practice quality, and efficiency. Residents were assigned to either the advanced access template (10 appointments available to patients and 2 physician overbooks) or the prior template (5 available and 8 overbooks). Outcomes included resident and patient satisfaction, appointment availability, and continuity of care and clinic costs. Patient satisfaction improved in 7 areas (P < .001). Residents in either template did not report an impact on medical education experiences. Significant increases were realized with appointment availability and the number of patients seen. Continuity also increased as the overflow/acute visits decreased (P < .001). Overall costs per visit decreased 22%. Because of the significant improvements in access, continuity, and efficiency, all residents were switched to the advanced access template after completion of the study. Improvement in access to the primary physician has a significant impact on patient satisfaction with health care delivery. This model optimizes the limited time that residents have in continuity clinic, and it has implications for health care delivery quality improvement.

Continuous Variable Quantum Key Distribution Using Polarized Coherent States

NASA Astrophysics Data System (ADS)

Vidiella-Barranco, A.; Borelli, L. F. M.

We discuss a continuous variables method of quantum key distribution employing strongly polarized coherent states of light. The key encoding is performed using the variables known as Stokes parameters, rather than the field quadratures. Their quantum counterpart, the Stokes operators Ŝi (i=1,2,3), constitute a set of non-commuting operators, being the precision of simultaneous measurements of a pair of them limited by an uncertainty-like relation. Alice transmits a conveniently modulated two-mode coherent state, and Bob randomly measures one of the Stokes parameters of the incoming beam. After performing reconciliation and privacy amplification procedures, it is possible to distill a secret common key. We also consider a non-ideal situation, in which coherent states with thermal noise, instead of pure coherent states, are used for encoding.

Inverse Ising problem in continuous time: A latent variable approach

NASA Astrophysics Data System (ADS)

Donner, Christian; Opper, Manfred

2017-12-01

We consider the inverse Ising problem: the inference of network couplings from observed spin trajectories for a model with continuous time Glauber dynamics. By introducing two sets of auxiliary latent random variables we render the likelihood into a form which allows for simple iterative inference algorithms with analytical updates. The variables are (1) Poisson variables to linearize an exponential term which is typical for point process likelihoods and (2) Pólya-Gamma variables, which make the likelihood quadratic in the coupling parameters. Using the augmented likelihood, we derive an expectation-maximization (EM) algorithm to obtain the maximum likelihood estimate of network parameters. Using a third set of latent variables we extend the EM algorithm to sparse couplings via L1 regularization. Finally, we develop an efficient approximate Bayesian inference algorithm using a variational approach. We demonstrate the performance of our algorithms on data simulated from an Ising model. For data which are simulated from a more biologically plausible network with spiking neurons, we show that the Ising model captures well the low order statistics of the data and how the Ising couplings are related to the underlying synaptic structure of the simulated network.

Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing.

PubMed

Zhang, Ping; Weeranoppanant, Nopphon; Thomas, Dale A; Tahara, Kohei; Stelzer, Torsten; Russell, Mary Grace; O'Mahony, Marcus; Myerson, Allan S; Lin, Hongkun; Kelly, Liam P; Jensen, Klavs F; Jamison, Timothy F; Dai, Chunhui; Cui, Yuqing; Briggs, Naomi; Beingessner, Rachel L; Adamo, Andrea

2018-02-21

As a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy time-scale, we previously reported a refrigerator-sized continuous flow system for the on-demand production of essential medicines. Building on this technology, herein we report a second-generation, reconfigurable and 25 % smaller (by volume) continuous flow pharmaceutical manufacturing platform featuring advances in reaction and purification equipment. Consisting of two compact [0.7 (L)×0.5 (D)×1.3 m (H)] stand-alone units for synthesis and purification/formulation processes, the capabilities of this automated system are demonstrated with the synthesis of nicardipine hydrochloride and the production of concentrated liquid doses of ciprofloxacin hydrochloride, neostigmine methylsulfate and rufinamide that meet US Pharmacopeia standards. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Advanced continuous cultivation methods for systems microbiology.

PubMed

Adamberg, Kaarel; Valgepea, Kaspar; Vilu, Raivo

2015-09-01

Increasing the throughput of systems biology-based experimental characterization of in silico-designed strains has great potential for accelerating the development of cell factories. For this, analysis of metabolism in the steady state is essential as only this enables the unequivocal definition of the physiological state of cells, which is needed for the complete description and in silico reconstruction of their phenotypes. In this review, we show that for a systems microbiology approach, high-resolution characterization of metabolism in the steady state--growth space analysis (GSA)--can be achieved by using advanced continuous cultivation methods termed changestats. In changestats, an environmental parameter is continuously changed at a constant rate within one experiment whilst maintaining cells in the physiological steady state similar to chemostats. This increases the resolution and throughput of GSA compared with chemostats, and, moreover, enables following of the dynamics of metabolism and detection of metabolic switch-points and optimal growth conditions. We also describe the concept, challenge and necessary criteria of the systematic analysis of steady-state metabolism. Finally, we propose that such systematic characterization of the steady-state growth space of cells using changestats has value not only for fundamental studies of metabolism, but also for systems biology-based metabolic engineering of cell factories.

Advances in Technology in Continuing Education: Who Should Foot the Bill?

ERIC Educational Resources Information Center

Hanson, Matthew

2013-01-01

Every continuing education unit must be at the forefront of the technology boom in order to remain attractive to students and best prepare them for the work force. Unfortunately, there is a significant cost associated with technological advancement sparking the debate over who should foot the bill for innovations. This article applies the Higher…

Efficient continuous-variable state tomography using Padua points

NASA Astrophysics Data System (ADS)

Landon-Cardinal, Olivier; Govia, Luke C. G.; Clerk, Aashish A.

Further development of quantum technologies calls for efficient characterization methods for quantum systems. While recent work has focused on discrete systems of qubits, much remains to be done for continuous-variable systems such as a microwave mode in a cavity. We introduce a novel technique to reconstruct the full Husimi Q or Wigner function from measurements done at the Padua points in phase space, the optimal sampling points for interpolation in 2D. Our technique not only reduces the number of experimental measurements, but remarkably, also allows for the direct estimation of any density matrix element in the Fock basis, including off-diagonal elements. OLC acknowledges financial support from NSERC.

Continuous-variable quantum teleportation in bosonic structured environments

DOE Office of Scientific and Technical Information (OSTI.GOV)

He Guangqiang; Zhang Jingtao; Zhu Jun

2011-09-15

The effects of dynamics of continuous-variable entanglement under the various kinds of environments on quantum teleportation are quantitatively investigated. Only under assumption of the weak system-reservoir interaction, the evolution of teleportation fidelity is analytically derived and is numerically plotted in terms of environment parameters including reservoir temperature and its spectral density, without Markovian and rotating wave approximations. We find that the fidelity of teleportation is a monotonically decreasing function for Markovian interaction in Ohmic-like environments, while it oscillates for non-Markovian ones. According to the dynamical laws of teleportation, teleportation with better performances can be implemented by selecting the appropriate time.

Continuous-variable gate decomposition for the Bose-Hubbard model

NASA Astrophysics Data System (ADS)

Kalajdzievski, Timjan; Weedbrook, Christian; Rebentrost, Patrick

2018-06-01

In this work, we decompose the time evolution of the Bose-Hubbard model into a sequence of logic gates that can be implemented on a continuous-variable photonic quantum computer. We examine the structure of the circuit that represents this time evolution for one-dimensional and two-dimensional lattices. The elementary gates needed for the implementation are counted as a function of lattice size. We also include the contribution of the leading dipole interaction term which may be added to the Hamiltonian and its corresponding circuit.

Continuous-variable quantum key distribution protocols over noisy channels.

PubMed

García-Patrón, Raúl; Cerf, Nicolas J

2009-04-03

A continuous-variable quantum key distribution protocol based on squeezed states and heterodyne detection is introduced and shown to attain higher secret key rates over a noisy line than any other one-way Gaussian protocol. This increased resistance to channel noise can be understood as resulting from purposely adding noise to the signal that is converted into the secret key. This notion of noise-enhanced tolerance to noise also provides a better physical insight into the poorly understood discrepancies between the previously defined families of Gaussian protocols.

Continuous-Variable Instantaneous Quantum Computing is Hard to Sample.

PubMed

Douce, T; Markham, D; Kashefi, E; Diamanti, E; Coudreau, T; Milman, P; van Loock, P; Ferrini, G

2017-02-17

Instantaneous quantum computing is a subuniversal quantum complexity class, whose circuits have proven to be hard to simulate classically in the discrete-variable realm. We extend this proof to the continuous-variable (CV) domain by using squeezed states and homodyne detection, and by exploring the properties of postselected circuits. In order to treat postselection in CVs, we consider finitely resolved homodyne detectors, corresponding to a realistic scheme based on discrete probability distributions of the measurement outcomes. The unavoidable errors stemming from the use of finitely squeezed states are suppressed through a qubit-into-oscillator Gottesman-Kitaev-Preskill encoding of quantum information, which was previously shown to enable fault-tolerant CV quantum computation. Finally, we show that, in order to render postselected computational classes in CVs meaningful, a logarithmic scaling of the squeezing parameter with the circuit size is necessary, translating into a polynomial scaling of the input energy.

Interval estimation and optimal design for the within-subject coefficient of variation for continuous and binary variables

PubMed Central

Shoukri, Mohamed M; Elkum, Nasser; Walter, Stephen D

2006-01-01

Background In this paper we propose the use of the within-subject coefficient of variation as an index of a measurement's reliability. For continuous variables and based on its maximum likelihood estimation we derive a variance-stabilizing transformation and discuss confidence interval construction within the framework of a one-way random effects model. We investigate sample size requirements for the within-subject coefficient of variation for continuous and binary variables. Methods We investigate the validity of the approximate normal confidence interval by Monte Carlo simulations. In designing a reliability study, a crucial issue is the balance between the number of subjects to be recruited and the number of repeated measurements per subject. We discuss efficiency of estimation and cost considerations for the optimal allocation of the sample resources. The approach is illustrated by an example on Magnetic Resonance Imaging (MRI). We also discuss the issue of sample size estimation for dichotomous responses with two examples. Results For the continuous variable we found that the variance stabilizing transformation improves the asymptotic coverage probabilities on the within-subject coefficient of variation for the continuous variable. The maximum like estimation and sample size estimation based on pre-specified width of confidence interval are novel contribution to the literature for the binary variable. Conclusion Using the sample size formulas, we hope to help clinical epidemiologists and practicing statisticians to efficiently design reliability studies using the within-subject coefficient of variation, whether the variable of interest is continuous or binary. PMID:16686943

Continuous-variable quantum computing on encrypted data.

PubMed

Marshall, Kevin; Jacobsen, Christian S; Schäfermeier, Clemens; Gehring, Tobias; Weedbrook, Christian; Andersen, Ulrik L

2016-12-14

The ability to perform computations on encrypted data is a powerful tool for protecting a client's privacy, especially in today's era of cloud and distributed computing. In terms of privacy, the best solutions that classical techniques can achieve are unfortunately not unconditionally secure in the sense that they are dependent on a hacker's computational power. Here we theoretically investigate, and experimentally demonstrate with Gaussian displacement and squeezing operations, a quantum solution that achieves the security of a user's privacy using the practical technology of continuous variables. We demonstrate losses of up to 10 km both ways between the client and the server and show that security can still be achieved. Our approach offers a number of practical benefits (from a quantum perspective) that could one day allow the potential widespread adoption of this quantum technology in future cloud-based computing networks.

Continuous-variable quantum computing on encrypted data

NASA Astrophysics Data System (ADS)

Marshall, Kevin; Jacobsen, Christian S.; Schäfermeier, Clemens; Gehring, Tobias; Weedbrook, Christian; Andersen, Ulrik L.

2016-12-01

The ability to perform computations on encrypted data is a powerful tool for protecting a client's privacy, especially in today's era of cloud and distributed computing. In terms of privacy, the best solutions that classical techniques can achieve are unfortunately not unconditionally secure in the sense that they are dependent on a hacker's computational power. Here we theoretically investigate, and experimentally demonstrate with Gaussian displacement and squeezing operations, a quantum solution that achieves the security of a user's privacy using the practical technology of continuous variables. We demonstrate losses of up to 10 km both ways between the client and the server and show that security can still be achieved. Our approach offers a number of practical benefits (from a quantum perspective) that could one day allow the potential widespread adoption of this quantum technology in future cloud-based computing networks.

Standardized Effect Sizes for Moderated Conditional Fixed Effects with Continuous Moderator Variables

PubMed Central

Bodner, Todd E.

2017-01-01

Wilkinson and Task Force on Statistical Inference (1999) recommended that researchers include information on the practical magnitude of effects (e.g., using standardized effect sizes) to distinguish between the statistical and practical significance of research results. To date, however, researchers have not widely incorporated this recommendation into the interpretation and communication of the conditional effects and differences in conditional effects underlying statistical interactions involving a continuous moderator variable where at least one of the involved variables has an arbitrary metric. This article presents a descriptive approach to investigate two-way statistical interactions involving continuous moderator variables where the conditional effects underlying these interactions are expressed in standardized effect size metrics (i.e., standardized mean differences and semi-partial correlations). This approach permits researchers to evaluate and communicate the practical magnitude of particular conditional effects and differences in conditional effects using conventional and proposed guidelines, respectively, for the standardized effect size and therefore provides the researcher important supplementary information lacking under current approaches. The utility of this approach is demonstrated with two real data examples and important assumptions underlying the standardization process are highlighted. PMID:28484404

Continuous-variable quantum key distribution with a leakage from state preparation

NASA Astrophysics Data System (ADS)

Derkach, Ivan; Usenko, Vladyslav C.; Filip, Radim

2017-12-01

We address side-channel leakage in a trusted preparation station of continuous-variable quantum key distribution with coherent and squeezed states. We consider two different scenarios: multimode Gaussian modulation, directly accessible to an eavesdropper, or side-channel loss of the signal states prior to the modulation stage. We show the negative impact of excessive modulation on both the coherent- and squeezed-state protocols. The impact is more pronounced for squeezed-state protocols and may require optimization of squeezing in the case of noisy quantum channels. Further, we demonstrate that the coherent-state protocol is immune to side-channel signal state leakage prior to modulation, while the squeezed-state protocol is vulnerable to such attacks, becoming more sensitive to the noise in the channel. In the general case of noisy quantum channels the signal squeezing can be optimized to provide best performance of the protocol in the presence of side-channel leakage prior to modulation. Our results demonstrate that leakage from the trusted source in continuous-variable quantum key distribution should not be underestimated and squeezing optimization is needed to overcome coherent state protocols.

Adaptive Quadrature Detection for Multicarrier Continuous-Variable Quantum Key Distribution

NASA Astrophysics Data System (ADS)

Gyongyosi, Laszlo; Imre, Sandor

2015-03-01

We propose the adaptive quadrature detection for multicarrier continuous-variable quantum key distribution (CVQKD). A multicarrier CVQKD scheme uses Gaussian subcarrier continuous variables for the information conveying and Gaussian sub-channels for the transmission. The proposed multicarrier detection scheme dynamically adapts to the sub-channel conditions using a corresponding statistics which is provided by our sophisticated sub-channel estimation procedure. The sub-channel estimation phase determines the transmittance coefficients of the sub-channels, which information are used further in the adaptive quadrature decoding process. We define the technique called subcarrier spreading to estimate the transmittance conditions of the sub-channels with a theoretical error-minimum in the presence of a Gaussian noise. We introduce the terms of single and collective adaptive quadrature detection. We also extend the results for a multiuser multicarrier CVQKD scenario. We prove the achievable error probabilities, the signal-to-noise ratios, and quantify the attributes of the framework. The adaptive detection scheme allows to utilize the extra resources of multicarrier CVQKD and to maximize the amount of transmittable information. This work was partially supported by the GOP-1.1.1-11-2012-0092 (Secure quantum key distribution between two units on optical fiber network) project sponsored by the EU and European Structural Fund, and by the COST Action MP1006.

Continuous-variable quantum computing on encrypted data

PubMed Central

Marshall, Kevin; Jacobsen, Christian S.; Schäfermeier, Clemens; Gehring, Tobias; Weedbrook, Christian; Andersen, Ulrik L.

2016-01-01

The ability to perform computations on encrypted data is a powerful tool for protecting a client's privacy, especially in today's era of cloud and distributed computing. In terms of privacy, the best solutions that classical techniques can achieve are unfortunately not unconditionally secure in the sense that they are dependent on a hacker's computational power. Here we theoretically investigate, and experimentally demonstrate with Gaussian displacement and squeezing operations, a quantum solution that achieves the security of a user's privacy using the practical technology of continuous variables. We demonstrate losses of up to 10 km both ways between the client and the server and show that security can still be achieved. Our approach offers a number of practical benefits (from a quantum perspective) that could one day allow the potential widespread adoption of this quantum technology in future cloud-based computing networks. PMID:27966528

GY SAMPLING THEORY AND GEOSTATISTICS: ALTERNATE MODELS OF VARIABILITY IN CONTINUOUS MEDIA

EPA Science Inventory

In the sampling theory developed by Pierre Gy, sample variability is modeled as the sum of a set of seven discrete error components. The variogram used in geostatisties provides an alternate model in which several of Gy's error components are combined in a continuous mode...

Secure Continuous Variable Teleportation and Einstein-Podolsky-Rosen Steering

NASA Astrophysics Data System (ADS)

He, Qiongyi; Rosales-Zárate, Laura; Adesso, Gerardo; Reid, Margaret D.

2015-10-01

We investigate the resources needed for secure teleportation of coherent states. We extend continuous variable teleportation to include quantum teleamplification protocols that allow nonunity classical gains and a preamplification or postattenuation of the coherent state. We show that, for arbitrary Gaussian protocols and a significant class of Gaussian resources, two-way steering is required to achieve a teleportation fidelity beyond the no-cloning threshold. This provides an operational connection between Gaussian steerability and secure teleportation. We present practical recipes suggesting that heralded noiseless preamplification may enable high-fidelity heralded teleportation, using minimally entangled yet steerable resources.

Use of generalised additive models to categorise continuous variables in clinical prediction

PubMed Central

2013-01-01

Background In medical practice many, essentially continuous, clinical parameters tend to be categorised by physicians for ease of decision-making. Indeed, categorisation is a common practice both in medical research and in the development of clinical prediction rules, particularly where the ensuing models are to be applied in daily clinical practice to support clinicians in the decision-making process. Since the number of categories into which a continuous predictor must be categorised depends partly on the relationship between the predictor and the outcome, the need for more than two categories must be borne in mind. Methods We propose a categorisation methodology for clinical-prediction models, using Generalised Additive Models (GAMs) with P-spline smoothers to determine the relationship between the continuous predictor and the outcome. The proposed method consists of creating at least one average-risk category along with high- and low-risk categories based on the GAM smooth function. We applied this methodology to a prospective cohort of patients with exacerbated chronic obstructive pulmonary disease. The predictors selected were respiratory rate and partial pressure of carbon dioxide in the blood (PCO2), and the response variable was poor evolution. An additive logistic regression model was used to show the relationship between the covariates and the dichotomous response variable. The proposed categorisation was compared to the continuous predictor as the best option, using the AIC and AUC evaluation parameters. The sample was divided into a derivation (60%) and validation (40%) samples. The first was used to obtain the cut points while the second was used to validate the proposed methodology. Results The three-category proposal for the respiratory rate was ≤ 20;(20,24];> 24, for which the following values were obtained: AIC=314.5 and AUC=0.638. The respective values for the continuous predictor were AIC=317.1 and AUC=0.634, with no statistically

CADDIS Volume 4. Data Analysis: Advanced Analyses - Controlling for Natural Variability: SSD Plot Diagrams

EPA Pesticide Factsheets

Methods for controlling natural variability, predicting environmental conditions from biological observations method, biological trait data, species sensitivity distributions, propensity scores, Advanced Analyses of Data Analysis references.

Continuous-variable quantum cryptography is secure against non-Gaussian attacks.

PubMed

Grosshans, Frédéric; Cerf, Nicolas J

2004-01-30

A general study of arbitrary finite-size coherent attacks against continuous-variable quantum cryptographic schemes is presented. It is shown that, if the size of the blocks that can be coherently attacked by an eavesdropper is fixed and much smaller than the key size, then the optimal attack for a given signal-to-noise ratio in the transmission line is an individual Gaussian attack. Consequently, non-Gaussian coherent attacks do not need to be considered in the security analysis of such quantum cryptosystems.

Quantification and scaling of multipartite entanglement in continuous variable systems.

PubMed

Adesso, Gerardo; Serafini, Alessio; Illuminati, Fabrizio

2004-11-26

We present a theoretical method to determine the multipartite entanglement between different partitions of multimode, fully or partially symmetric Gaussian states of continuous variable systems. For such states, we determine the exact expression of the logarithmic negativity and show that it coincides with that of equivalent two-mode Gaussian states. Exploiting this reduction, we demonstrate the scaling of the multipartite entanglement with the number of modes and its reliable experimental estimate by direct measurements of the global and local purities.

Security of continuous-variable quantum key distribution against general attacks.

PubMed

Leverrier, Anthony; García-Patrón, Raúl; Renner, Renato; Cerf, Nicolas J

2013-01-18

We prove the security of Gaussian continuous-variable quantum key distribution with coherent states against arbitrary attacks in the finite-size regime. In contrast to previously known proofs of principle (based on the de Finetti theorem), our result is applicable in the practically relevant finite-size regime. This is achieved using a novel proof approach, which exploits phase-space symmetries of the protocols as well as the postselection technique introduced by Christandl, Koenig, and Renner [Phys. Rev. Lett. 102, 020504 (2009)].

Continuous performance task in ADHD: Is reaction time variability a key measure?

PubMed

Levy, Florence; Pipingas, Andrew; Harris, Elizabeth V; Farrow, Maree; Silberstein, Richard B

2018-01-01

To compare the use of the Continuous Performance Task (CPT) reaction time variability (intraindividual variability or standard deviation of reaction time), as a measure of vigilance in attention-deficit hyperactivity disorder (ADHD), and stimulant medication response, utilizing a simple CPT X-task vs an A-X-task. Comparative analyses of two separate X-task vs A-X-task data sets, and subgroup analyses of performance on and off medication were conducted. The CPT X-task reaction time variability had a direct relationship to ADHD clinician severity ratings, unlike the CPT A-X-task. Variability in X-task performance was reduced by medication compared with the children's unmedicated performance, but this effect did not reach significance. When the coefficient of variation was applied, severity measures and medication response were significant for the X-task, but not for the A-X-task. The CPT-X-task is a useful clinical screening test for ADHD and medication response. In particular, reaction time variability is related to default mode interference. The A-X-task is less useful in this regard.

Improvement of two-way continuous-variable quantum key distribution with virtual photon subtraction

NASA Astrophysics Data System (ADS)

Zhao, Yijia; Zhang, Yichen; Li, Zhengyu; Yu, Song; Guo, Hong

2017-08-01

We propose a method to improve the performance of two-way continuous-variable quantum key distribution protocol by virtual photon subtraction. The virtual photon subtraction implemented via non-Gaussian post-selection not only enhances the entanglement of two-mode squeezed vacuum state but also has advantages in simplifying physical operation and promoting efficiency. In two-way protocol, virtual photon subtraction could be applied on two sources independently. Numerical simulations show that the optimal performance of renovated two-way protocol is obtained with photon subtraction only used by Alice. The transmission distance and tolerable excess noise are improved by using the virtual photon subtraction with appropriate parameters. Moreover, the tolerable excess noise maintains a high value with the increase in distance so that the robustness of two-way continuous-variable quantum key distribution system is significantly improved, especially at long transmission distance.

Universal Quantum Computing with Measurement-Induced Continuous-Variable Gate Sequence in a Loop-Based Architecture

NASA Astrophysics Data System (ADS)

Takeda, Shuntaro; Furusawa, Akira

2017-09-01

We propose a scalable scheme for optical quantum computing using measurement-induced continuous-variable quantum gates in a loop-based architecture. Here, time-bin-encoded quantum information in a single spatial mode is deterministically processed in a nested loop by an electrically programmable gate sequence. This architecture can process any input state and an arbitrary number of modes with almost minimum resources, and offers a universal gate set for both qubits and continuous variables. Furthermore, quantum computing can be performed fault tolerantly by a known scheme for encoding a qubit in an infinite-dimensional Hilbert space of a single light mode.

Universal Quantum Computing with Measurement-Induced Continuous-Variable Gate Sequence in a Loop-Based Architecture.

PubMed

Takeda, Shuntaro; Furusawa, Akira

2017-09-22

We propose a scalable scheme for optical quantum computing using measurement-induced continuous-variable quantum gates in a loop-based architecture. Here, time-bin-encoded quantum information in a single spatial mode is deterministically processed in a nested loop by an electrically programmable gate sequence. This architecture can process any input state and an arbitrary number of modes with almost minimum resources, and offers a universal gate set for both qubits and continuous variables. Furthermore, quantum computing can be performed fault tolerantly by a known scheme for encoding a qubit in an infinite-dimensional Hilbert space of a single light mode.

Computer Simulations and Literature Survey of Continuously Variable Transmissions for Use in Buses

DOT National Transportation Integrated Search

1981-12-01

Numerous studies have been conducted on the concept of flywheel energy storage for buses. Flywheel systems require a continuously variable transmission (CVT) of some type to transmit power between the flywheel and the drive wheels. However, a CVT can...

Continuous-variable entanglement distillation of non-Gaussian mixed states

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dong Ruifang; Lassen, Mikael; Department of Physics, Technical University of Denmark, Building 309, DK-2800 Lyngby

2010-07-15

Many different quantum-information communication protocols such as teleportation, dense coding, and entanglement-based quantum key distribution are based on the faithful transmission of entanglement between distant location in an optical network. The distribution of entanglement in such a network is, however, hampered by loss and noise that is inherent in all practical quantum channels. Thus, to enable faithful transmission one must resort to the protocol of entanglement distillation. In this paper we present a detailed theoretical analysis and an experimental realization of continuous variable entanglement distillation in a channel that is inflicted by different kinds of non-Gaussian noise. The continuous variablemore » entangled states are generated by exploiting the third order nonlinearity in optical fibers, and the states are sent through a free-space laboratory channel in which the losses are altered to simulate a free-space atmospheric channel with varying losses. We use linear optical components, homodyne measurements, and classical communication to distill the entanglement, and we find that by using this method the entanglement can be probabilistically increased for some specific non-Gaussian noise channels.« less

High-efficiency reconciliation for continuous variable quantum key distribution

NASA Astrophysics Data System (ADS)

Bai, Zengliang; Yang, Shenshen; Li, Yongmin

2017-04-01

Quantum key distribution (QKD) is the most mature application of quantum information technology. Information reconciliation is a crucial step in QKD and significantly affects the final secret key rates shared between two legitimate parties. We analyze and compare various construction methods of low-density parity-check (LDPC) codes and design high-performance irregular LDPC codes with a block length of 106. Starting from these good codes and exploiting the slice reconciliation technique based on multilevel coding and multistage decoding, we realize high-efficiency Gaussian key reconciliation with efficiency higher than 95% for signal-to-noise ratios above 1. Our demonstrated method can be readily applied in continuous variable QKD.

Invited Article: Generation of one-million-mode continuous-variable cluster state by unlimited time-domain multiplexing

NASA Astrophysics Data System (ADS)

Yoshikawa, Jun-ichi; Yokoyama, Shota; Kaji, Toshiyuki; Sornphiphatphong, Chanond; Shiozawa, Yu; Makino, Kenzo; Furusawa, Akira

2016-09-01

In recent quantum optical continuous-variable experiments, the number of fully inseparable light modes has drastically increased by introducing a multiplexing scheme either in the time domain or in the frequency domain. Here, modifying the time-domain multiplexing experiment reported in the work of Yokoyama et al. [Nat. Photonics 7, 982 (2013)], we demonstrate the successive generation of fully inseparable light modes for more than one million modes. The resulting multi-mode state is useful as a dual-rail continuous variable cluster state. We circumvent the previous problem of optical phase drifts, which has limited the number of fully inseparable light modes to around ten thousands, by continuous feedback control of the optical system.

One-step generation of continuous-variable quadripartite cluster states in a circuit QED system

NASA Astrophysics Data System (ADS)

Yang, Zhi-peng; Li, Zhen; Ma, Sheng-li; Li, Fu-li

2017-07-01

We propose a dissipative scheme for one-step generation of continuous-variable quadripartite cluster states in a circuit QED setup consisting of four superconducting coplanar waveguide resonators and a gap-tunable superconducting flux qubit. With external driving fields to adjust the desired qubit-resonator and resonator-resonator interactions, we show that continuous-variable quadripartite cluster states of the four resonators can be generated with the assistance of energy relaxation of the qubit. By comparison with the previous proposals, the distinct advantage of our scheme is that only one step of quantum operation is needed to realize the quantum state engineering. This makes our scheme simpler and more feasible in experiment. Our result may have useful application for implementing quantum computation in solid-state circuit QED systems.

A 24 km fiber-based discretely signaled continuous variable quantum key distribution system.

PubMed

Dinh Xuan, Quyen; Zhang, Zheshen; Voss, Paul L

2009-12-21

We report a continuous variable key distribution system that achieves a final secure key rate of 3.45 kilobits/s over a distance of 24.2 km of optical fiber. The protocol uses discrete signaling and post-selection to improve reconciliation speed and quantifies security by means of quantum state tomography. Polarization multiplexing and a frequency translation scheme permit transmission of a continuous wave local oscillator and suppression of noise from guided acoustic wave Brillouin scattering by more than 27 dB.

Multivariate normal maximum likelihood with both ordinal and continuous variables, and data missing at random.

PubMed

Pritikin, Joshua N; Brick, Timothy R; Neale, Michael C

2018-04-01

A novel method for the maximum likelihood estimation of structural equation models (SEM) with both ordinal and continuous indicators is introduced using a flexible multivariate probit model for the ordinal indicators. A full information approach ensures unbiased estimates for data missing at random. Exceeding the capability of prior methods, up to 13 ordinal variables can be included before integration time increases beyond 1 s per row. The method relies on the axiom of conditional probability to split apart the distribution of continuous and ordinal variables. Due to the symmetry of the axiom, two similar methods are available. A simulation study provides evidence that the two similar approaches offer equal accuracy. A further simulation is used to develop a heuristic to automatically select the most computationally efficient approach. Joint ordinal continuous SEM is implemented in OpenMx, free and open-source software.

Continuous subcutaneous infusion of lidocaine for persistent hiccup in advanced cancer.

PubMed

Kaneishi, Keisuke; Kawabata, Masahiro

2013-03-01

Persistent hiccup can cause anorexia, weight loss, disabling sleep deprivation, anxiety, and depression. Therefore, relief of persistent hiccup is important for advanced cancer patients and their family. Most reports on this condition are case series reports advocating the use of baclofen, haloperidol, gabapentin, and midazolam. However, these medications are occasionally ineffective or accompanied by intolerable side effects. The sodium channel blocker lidocaine has been shown to be effective in treating a variety of disorders thought to involve neuropathic mechanisms. Intravenous administration of lidocaine is common but efficacy has also been reported for subcutaneous infusion. In advanced cancer patients, subcutaneous infusion is easy, advantageous, and accompanied by less discomfort. We report a case of severe and sustained hiccup caused by gastric cancer that was successfully treated with a continuous subcutaneous infusion of lidocaine (480 mg (24 ml)/day) without severe side effects.

The Continuing Search for Variability Among Cool White Dwarfs

NASA Astrophysics Data System (ADS)

Schaefer, J. J.; Oswalt, T. D.; Johnston, K. B.; Rudkin, M.; Heinz, T.

2002-12-01

The Continuing Search for Variability Among Cool White Dwarfs Justin J. Schaefer University of Wyoming Department of Physics and Astronomy P.O. Box 3905 Laramie, Wyoming 82071 USA (schaefju@uwyo.edu) Terry D. Oswalt, Kyle Johnston, Merissa Rudkin, Tamalyn Heinz Florida Institute of Technology and the SARA Observatory Department of Physics & Space Sciences 150 West University Boulevard Melbourne, Florida 32901 USA (oswalt@luyten.astro.fit.edu, kyjohnst@fit.edu, mrudkin@astro.fit.edu, theinz@fit.edu) ABSTRACT We present BVRI photometry of eleven binaries with white dwarf (WD) components. The observations were obtained at the SARA 0.9-meter telescope on Kitt Peak during the summer of 2002. Standard system (B-V), (V-R) and (R-I) color indices of four white dwarfs were determined. This data will be used to estimate the WD cooling ages in wide WD+dM binaries, as part of our ongoing research program to determine the chromospheric activity-age relation for M dwarf stars. Time-series differential photometry was also collected for eight cool white dwarfs as part of a program to explore the variability in the low luminosity, low temperature regime of the WD cooling track. We failed to detect any variability greater than ~0.04 magnitudes in these stars. Several nights of differential photometry data were collected on the DAO WD + K dwarf short-period variable HS1136+6646. From the light variations we determined a likely orbital period of 0.825 +/-0.009 days. Strong evidence is presented for two other possible periods within this light curve, possibly indicative of rotational modulation by the WD component. We gratefully acknowledge support from the National Science Foundation, which funds the SARA Research Experiences for Undergraduates program via grant AST-0097616 to Florida Tech. One of us (TDO) also acknowledges partial support for this work from NASA (subcontract Y701296) and the NSF (AST 0206115).

The intention to continue nursing: work variables affecting three nurse generations in Australia.

PubMed

Shacklock, Kate; Brunetto, Yvonne

2012-01-01

The aims of the study were to examine how seven variables impacted upon the intention of hospital nurses to continue working as nurses and to investigate whether there are generational differences in these impacts. There is a critical shortage of trained nurses working as nurses in Australia, as in many other Organisation for Economic Co-operation and Development member countries. The retention of nurses has been examined from the traditional management perspectives; however, this paper presents a different approach (Meaning of Working theory). A self-report survey of 900 nurses employed across four states of Australia was completed in 2008. The sample was hospital nurses in Australia from three generational cohorts - Baby Boomers (born in Australia between 1946 and 1964), Generation X (1965-1979) and Generation Y (1980-2000). Six variables were found to influence the combined nurses' intentions to continue working as nurses: work-family conflict, perceptions of autonomy, attachment to work, importance of working to the individual, supervisor-subordinate relationship and interpersonal relationships at work. There were differences in the variables affecting the three generations, but attachment to work was the only common variable across all generations, affecting GenYs the strongest. The shortage of nurses is conceptualized differently in this paper to assist in finding solutions. However, the results varied for the three generations, suggesting the need to tailor different retention strategies to each age group. Implications for management and policy planning are discussed. © 2011 Blackwell Publishing Ltd.

Discrete and continuous variables for measurement-device-independent quantum cryptography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu, Feihu; Curty, Marcos; Qi, Bing

In a recent Article in Nature Photonics, Pirandola et al.1 claim that the achievable secret key rates of discrete-variable (DV) measurementdevice- independent (MDI) quantum key distribution (QKD) (refs 2,3) are “typically very low, unsuitable for the demands of a metropolitan network” and introduce a continuous-variable (CV) MDI QKD protocol capable of providing key rates which, they claim, are “three orders of magnitude higher” than those of DV MDI QKD. We believe, however, that the claims regarding low key rates of DV MDI QKD made by Pirandola et al.1 are too pessimistic. Here in this paper, we show that the secretmore » key rate of DV MDI QKD with commercially available high-efficiency single-photon detectors (SPDs) (for example, see http://www.photonspot.com/detectors and http://www.singlequantum.com) and good system alignment is typically rather high and thus highly suitable for not only long-distance communication but also metropolitan networks.« less

Discrete and continuous variables for measurement-device-independent quantum cryptography

DOE PAGES

Xu, Feihu; Curty, Marcos; Qi, Bing; ...

2015-11-16

In a recent Article in Nature Photonics, Pirandola et al.1 claim that the achievable secret key rates of discrete-variable (DV) measurementdevice- independent (MDI) quantum key distribution (QKD) (refs 2,3) are “typically very low, unsuitable for the demands of a metropolitan network” and introduce a continuous-variable (CV) MDI QKD protocol capable of providing key rates which, they claim, are “three orders of magnitude higher” than those of DV MDI QKD. We believe, however, that the claims regarding low key rates of DV MDI QKD made by Pirandola et al.1 are too pessimistic. Here in this paper, we show that the secretmore » key rate of DV MDI QKD with commercially available high-efficiency single-photon detectors (SPDs) (for example, see http://www.photonspot.com/detectors and http://www.singlequantum.com) and good system alignment is typically rather high and thus highly suitable for not only long-distance communication but also metropolitan networks.« less

A nano continuous variable transmission system from nanotubes

NASA Astrophysics Data System (ADS)

Cai, Kun; Shi, Jiao; Xie, Yi Min; Qin, Qing H.

2018-02-01

A nano continuous variable transmission (nano-CVT) system is proposed by means of carbon nanotubes (CNTs). The dynamic behavior of the CNT-based nanosystem is assessed using molecular dynamics simulations. The system contains a rotary CNT-motor and a CNT-bearing. The tube axes of the nanomotor and the rotor in the bearing are laid in parallel, and the distance between them is known as the eccentricity of the rotor with a diameter of d. By changing the eccentricity (e) of the rotor from 0 to d, some interesting rotation transmission phenomena are discovered, whose procedures can be used to design various nanodevices. This might include the failure of rotation transmission—i.e. the rotor has no rotation—when e ≥ d at an extremely low temperature, or when the edges of the two tubes are orthogonal at their intersections in any condition. This hints that the state of the nanosystem can be used as an on/off switch or breaker. For a system with e = d and a high temperature, the rotor rotates in the reverse direction of the motor. This means that the output signal (rotation) is the reverse of the input signal. When changing the eccentricity from 0 to d continuously, the output signal gradually decreases from a positive value to a negative value; as a result a nano-CVT system is obtained.

Continuous-variable quantum key distribution in non-Markovian channels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vasile, Ruggero; Olivares, Stefano; CNISM, Unita di Ricerca di Milano Universita, I-20133 Milano

2011-04-15

We address continuous-variable quantum key distribution (QKD) in non-Markovian lossy channels and show how the non-Markovian features may be exploited to enhance security and/or to detect the presence and the position of an eavesdropper along the transmission line. In particular, we suggest a coherent-state QKD protocol which is secure against Gaussian individual attacks based on optimal 1{yields}2 asymmetric cloning machines for arbitrarily low values of the overall transmission line. The scheme relies on specific non-Markovian properties, and cannot be implemented in ordinary Markovian channels characterized by uniform losses. Our results give a clear indication of the potential impact of non-Markovianmore » effects in QKD.« less

Key variables analysis of a novel continuous biodrying process for drying mixed sludge.

PubMed

Navaee-Ardeh, Shahram; Bertrand, François; Stuart, Paul R

2010-05-01

A novel continuous biodrying process has been developed whose goal is to increase the dry solids content of the sludge to economic levels rendering it suitable for a safe and economic combustion operation in a biomass boiler. The sludge drying rates are enhanced by the metabolic bioheat produced in the matrix of mixed sludge. The goal of this study was to systematically analyze the continuous biodrying reactor. By performing a variable analysis, it was found that the outlet relative humidity profile was the key variable in the biodrying reactor. The influence of different outlet relative humidity profiles was then evaluated using biodrying efficiency index. It was found that by maintaining the air outlet relative humidity profile at 85/85/96/96% in the four compartments of the reactor, the highest biodrying efficiency index can be achieved, while economic dry solids level (>45%w/w) are guaranteed. Crown Copyright 2009. Published by Elsevier Ltd. All rights reserved.

Six-minute walk test and heart rate variability: lack of association in advanced stages of heart failure.

PubMed

Woo, M A; Moser, D K; Stevenson, L W; Stevenson, W G

1997-09-01

The 6-minute walk and heart rate variability have been used to assess mortality risk in patients with heart failure, but their relationship to each other and their usefulness for predicting mortality at 1 year are unknown. To assess the relationships between the 6-minute walk test, heart rate variability, and 1-year mortality. A sample of 113 patients in advanced stages of heart failure (New York Heart Association Functional Class III-IV, left ventricular ejection < 0.25) were studied. All 6-minute walks took place in an enclosed, level, measured corridor and were supervised by the same nurse. Heart rate variability was measured by using (1) a standard-deviation method and (2) Poincaré plots. Data on RR intervals obtained by using 24-hour Holter monitoring were analyzed. Survival was determined at 1 year after the Holter recording. The results showed no significant associations between the results of the 6-minute walk and the two measures of heart rate variability. The results of the walk were related to 1-year mortality but not to the risk of sudden death. Both measures of heart rate variability had significant associations with 1-year mortality and with sudden death. However, only heart rate variability measured by using Poincaré plots was a predictor of total mortality and risk of sudden death, independent of left ventricular ejection fraction, serum levels of sodium, results of the 6-minute walk test, and the standard-deviation measure of heart rate variability. Results of the 6-minute walk have poor association with mortality and the two measures of heart rate variability in patients with advanced-stage heart failure and a low ejection fraction. Further studies are needed to determine the optimal clinical usefulness of the 6-minute walk and heart rate variability in patients with advanced-stage heart failure.

Multipartite entanglement in three-mode Gaussian states of continuous-variable systems: Quantification, sharing structure, and decoherence

NASA Astrophysics Data System (ADS)

Adesso, Gerardo; Serafini, Alessio; Illuminati, Fabrizio

2006-03-01

We present a complete analysis of the multipartite entanglement of three-mode Gaussian states of continuous-variable systems. We derive standard forms which characterize the covariance matrix of pure and mixed three-mode Gaussian states up to local unitary operations, showing that the local entropies of pure Gaussian states are bound to fulfill a relationship which is stricter than the general Araki-Lieb inequality. Quantum correlations can be quantified by a proper convex roof extension of the squared logarithmic negativity, the continuous-variable tangle, or contangle. We review and elucidate in detail the proof that in multimode Gaussian states the contangle satisfies a monogamy inequality constraint [G. Adesso and F. Illuminati, New J. Phys8, 15 (2006)]. The residual contangle, emerging from the monogamy inequality, is an entanglement monotone under Gaussian local operations and classical communications and defines a measure of genuine tripartite entanglements. We determine the analytical expression of the residual contangle for arbitrary pure three-mode Gaussian states and study in detail the distribution of quantum correlations in such states. This analysis yields that pure, symmetric states allow for a promiscuous entanglement sharing, having both maximum tripartite entanglement and maximum couplewise entanglement between any pair of modes. We thus name these states GHZ/W states of continuous-variable systems because they are simultaneous continuous-variable counterparts of both the GHZ and the W states of three qubits. We finally consider the effect of decoherence on three-mode Gaussian states, studying the decay of the residual contangle. The GHZ/W states are shown to be maximally robust against losses and thermal noise.

Destructive Thomas Fire Continues Its Advance in New NASA Satellite Image

NASA Image and Video Library

2017-12-11

The Thomas fire, west of Los Angeles, continues to advance to the west and north and is threatening a number of coastal communities, including Santa Barbara. It is now the fifth largest wildfire in modern California history. According to CAL FIRE, as of midday Dec. 11, the fire had consumed more than 230,000 acres and was 15 percent contained. The Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) instrument on NASA's Terra satellite captured this image on Dec. 10. The image depicts vegetation in red, smoke in light brown, burned areas in dark grey, and active fires in yellow, as detected by the thermal infrared bands. The image covers an area of 14.3 by 19.6 miles (23 by 31.5 kilometers), and is located at 34.5 degrees north, 119.4 degrees west. https://photojournal.jpl.nasa.gov/catalog/PIA22122

Prediction of Indian Summer-Monsoon Onset Variability: A Season in Advance.

PubMed

Pradhan, Maheswar; Rao, A Suryachandra; Srivastava, Ankur; Dakate, Ashish; Salunke, Kiran; Shameera, K S

2017-10-27

Monsoon onset is an inherent transient phenomenon of Indian Summer Monsoon and it was never envisaged that this transience can be predicted at long lead times. Though onset is precipitous, its variability exhibits strong teleconnections with large scale forcing such as ENSO and IOD and hence may be predictable. Despite of the tremendous skill achieved by the state-of-the-art models in predicting such large scale processes, the prediction of monsoon onset variability by the models is still limited to just 2-3 weeks in advance. Using an objective definition of onset in a global coupled ocean-atmosphere model, it is shown that the skillful prediction of onset variability is feasible under seasonal prediction framework. The better representations/simulations of not only the large scale processes but also the synoptic and intraseasonal features during the evolution of monsoon onset are the comprehensions behind skillful simulation of monsoon onset variability. The changes observed in convection, tropospheric circulation and moisture availability prior to and after the onset are evidenced in model simulations, which resulted in high hit rate of early/delay in monsoon onset in the high resolution model.

Continuous-variable measurement-device-independent quantum key distribution with virtual photon subtraction

NASA Astrophysics Data System (ADS)

Zhao, Yijia; Zhang, Yichen; Xu, Bingjie; Yu, Song; Guo, Hong

2018-04-01

The method of improving the performance of continuous-variable quantum key distribution protocols by postselection has been recently proposed and verified. In continuous-variable measurement-device-independent quantum key distribution (CV-MDI QKD) protocols, the measurement results are obtained from untrusted third party Charlie. There is still not an effective method of improving CV-MDI QKD by the postselection with untrusted measurement. We propose a method to improve the performance of coherent-state CV-MDI QKD protocol by virtual photon subtraction via non-Gaussian postselection. The non-Gaussian postselection of transmitted data is equivalent to an ideal photon subtraction on the two-mode squeezed vacuum state, which is favorable to enhance the performance of CV-MDI QKD. In CV-MDI QKD protocol with non-Gaussian postselection, two users select their own data independently. We demonstrate that the optimal performance of the renovated CV-MDI QKD protocol is obtained with the transmitted data only selected by Alice. By setting appropriate parameters of the virtual photon subtraction, the secret key rate and tolerable excess noise are both improved at long transmission distance. The method provides an effective optimization scheme for the application of CV-MDI QKD protocols.

Quantum hacking of two-way continuous-variable quantum key distribution using Trojan-horse attack

NASA Astrophysics Data System (ADS)

Ma, Hong-Xin; Bao, Wan-Su; Li, Hong-Wei; Chou, Chun

2016-08-01

We present a Trojan-horse attack on the practical two-way continuous-variable quantum key distribution system. Our attack mainly focuses on the imperfection of the practical system that the modulator has a redundancy of modulation pulse-width, which leaves a loophole for the eavesdropper inserting a Trojan-horse pulse. Utilizing the unique characteristics of two-way continuous-variable quantum key distribution that Alice only takes modulation operation on the received mode without any measurement, this attack allows the eavesdropper to render all of the final keys shared between the legitimate parties insecure without being detected. After analyzing the feasibility of the attack, the corresponding countermeasures are put forward. Project supported by the National Basic Research Program of China (Grant No. 2013CB338002) and the National Natural Science Foundation of China (Grant Nos. 11304397 and 61505261).

Optimized tomography of continuous variable systems using excitation counting

NASA Astrophysics Data System (ADS)

Shen, Chao; Heeres, Reinier W.; Reinhold, Philip; Jiang, Luyao; Liu, Yi-Kai; Schoelkopf, Robert J.; Jiang, Liang

2016-11-01

We propose a systematic procedure to optimize quantum state tomography protocols for continuous variable systems based on excitation counting preceded by a displacement operation. Compared with conventional tomography based on Husimi or Wigner function measurement, the excitation counting approach can significantly reduce the number of measurement settings. We investigate both informational completeness and robustness, and provide a bound of reconstruction error involving the condition number of the sensing map. We also identify the measurement settings that optimize this error bound, and demonstrate that the improved reconstruction robustness can lead to an order-of-magnitude reduction of estimation error with given resources. This optimization procedure is general and can incorporate prior information of the unknown state to further simplify the protocol.

Continuous variable quantum cryptography: beating the 3 dB loss limit.

PubMed

Silberhorn, Ch; Ralph, T C; Lütkenhaus, N; Leuchs, G

2002-10-14

We demonstrate that secure quantum key distribution systems based on continuous variable implementations can operate beyond the apparent 3 dB loss limit that is implied by the beam splitting attack. The loss limit was established for standard minimum uncertainty states such as coherent states. We show that, by an appropriate postselection mechanism, we can enter a region where Eve's knowledge on Alice's key falls behind the information shared between Alice and Bob, even in the presence of substantial losses.

A Hierarchical Modulation Coherent Communication Scheme for Simultaneous Four-State Continuous-Variable Quantum Key Distribution and Classical Communication

NASA Astrophysics Data System (ADS)

Yang, Can; Ma, Cheng; Hu, Linxi; He, Guangqiang

2018-06-01

We present a hierarchical modulation coherent communication protocol, which simultaneously achieves classical optical communication and continuous-variable quantum key distribution. Our hierarchical modulation scheme consists of a quadrature phase-shifting keying modulation for classical communication and a four-state discrete modulation for continuous-variable quantum key distribution. The simulation results based on practical parameters show that it is feasible to transmit both quantum information and classical information on a single carrier. We obtained a secure key rate of 10^{-3} bits/pulse to 10^{-1} bits/pulse within 40 kilometers, and in the meantime the maximum bit error rate for classical information is about 10^{-7}. Because continuous-variable quantum key distribution protocol is compatible with standard telecommunication technology, we think our hierarchical modulation scheme can be used to upgrade the digital communication systems to extend system function in the future.

Advancements for continuous miners

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fiscor, S.

2007-06-15

Design changes and new technology make the modern continuous miner more user friendly. Two of the major manufacturers, Joy Mining Machinery and DBT, both based near Pittsburgh, PA, USA, have recently acquired other OEMs to offer a greater product line. Joy's biggest development in terms of improving cutting time is the FACEBOSS Control System which has an operator assistance element and Joy Surface Reporting Software (JSRP). Joy's WetHead continuous miners have excellent performance. DBT is researching ways to make the machines more reliable with new drive systems. It has also been experimenting with water sprays to improve dust suppression. 4more » photos.« less

Multipartite entanglement in three-mode Gaussian states of continuous-variable systems: Quantification, sharing structure, and decoherence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adesso, Gerardo; Centre for Quantum Computation, DAMTP, Centre for Mathematical Sciences, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA; Serafini, Alessio

2006-03-15

We present a complete analysis of the multipartite entanglement of three-mode Gaussian states of continuous-variable systems. We derive standard forms which characterize the covariance matrix of pure and mixed three-mode Gaussian states up to local unitary operations, showing that the local entropies of pure Gaussian states are bound to fulfill a relationship which is stricter than the general Araki-Lieb inequality. Quantum correlations can be quantified by a proper convex roof extension of the squared logarithmic negativity, the continuous-variable tangle, or contangle. We review and elucidate in detail the proof that in multimode Gaussian states the contangle satisfies a monogamy inequalitymore » constraint [G. Adesso and F. Illuminati, New J. Phys8, 15 (2006)]. The residual contangle, emerging from the monogamy inequality, is an entanglement monotone under Gaussian local operations and classical communications and defines a measure of genuine tripartite entanglements. We determine the analytical expression of the residual contangle for arbitrary pure three-mode Gaussian states and study in detail the distribution of quantum correlations in such states. This analysis yields that pure, symmetric states allow for a promiscuous entanglement sharing, having both maximum tripartite entanglement and maximum couplewise entanglement between any pair of modes. We thus name these states GHZ/W states of continuous-variable systems because they are simultaneous continuous-variable counterparts of both the GHZ and the W states of three qubits. We finally consider the effect of decoherence on three-mode Gaussian states, studying the decay of the residual contangle. The GHZ/W states are shown to be maximally robust against losses and thermal noise.« less

Quantum anonymous voting with unweighted continuous-variable graph states

NASA Astrophysics Data System (ADS)

Guo, Ying; Feng, Yanyan; Zeng, Guihua

2016-08-01

Motivated by the revealing topological structures of continuous-variable graph state (CVGS), we investigate the design of quantum voting scheme, which has serious advantages over the conventional ones in terms of efficiency and graphicness. Three phases are included, i.e., the preparing phase, the voting phase and the counting phase, together with three parties, i.e., the voters, the tallyman and the ballot agency. Two major voting operations are performed on the yielded CVGS in the voting process, namely the local rotation transformation and the displacement operation. The voting information is carried by the CVGS established before hand, whose persistent entanglement is deployed to keep the privacy of votes and the anonymity of legal voters. For practical applications, two CVGS-based quantum ballots, i.e., comparative ballot and anonymous survey, are specially designed, followed by the extended ballot schemes for the binary-valued and multi-valued ballots under some constraints for the voting design. Security is ensured by entanglement of the CVGS, the voting operations and the laws of quantum mechanics. The proposed schemes can be implemented using the standard off-the-shelf components when compared to discrete-variable quantum voting schemes attributing to the characteristics of the CV-based quantum cryptography.

Generation of 8.3 dB continuous variable quantum entanglement at a telecommunication wavelength of 1550 nm

NASA Astrophysics Data System (ADS)

Jinxia, Feng; Zhenju, Wan; Yuanji, Li; Kuanshou, Zhang

2018-01-01

Continuous variable quantum entanglement at a telecommunication wavelength of 1550 nm is experimentally generated using a single nondegenerate optical parametric amplifier based on a type-II periodically poled KTiOPO4 crystal. The triply resonant of the nondegenerate optical parametric amplifier is adjusted by tuning the crystal temperature and tilting the orientation of the crystal in the optical cavity. Einstein-Podolsky-Rosen-entangled beams with quantum correlations of 8.3 dB for both the amplitude and phase quadratures are experimentally generated. This system can be used for continuous variable fibre-based quantum communication.

Design study of a continuously variable roller cone traction CVT for electric vehicles

NASA Technical Reports Server (NTRS)

Mccoin, D. K.; Walker, R. D.

1980-01-01

Continuously variable ratio transmissions (CVT) featuring cone and roller traction elements and computerized controls are studied. The CVT meets or exceeds all requirements set forth in the design criteria. Further, a scalability analysis indicates the basic concept is applicable to lower and higher power units, with upward scaling for increased power being more readily accomplished.

Continuous-variable quantum-key-distribution protocols with a non-Gaussian modulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leverrier, Anthony; Grangier, Philippe; Laboratoire Charles Fabry, Institut d'Optique, CNRS, Univ. Paris-Sud, Campus Polytechnique, RD 128, F-91127 Palaiseau Cedex

2011-04-15

In this paper, we consider continuous-variable quantum-key-distribution (QKD) protocols which use non-Gaussian modulations. These specific modulation schemes are compatible with very efficient error-correction procedures, hence allowing the protocols to outperform previous protocols in terms of achievable range. In their simplest implementation, these protocols are secure for any linear quantum channels (hence against Gaussian attacks). We also show how the use of decoy states makes the protocols secure against arbitrary collective attacks, which implies their unconditional security in the asymptotic limit.

Robust shot-noise measurement for continuous-variable quantum key distribution

NASA Astrophysics Data System (ADS)

Kunz-Jacques, Sébastien; Jouguet, Paul

2015-02-01

We study a practical method to measure the shot noise in real time in continuous-variable quantum key distribution systems. The amount of secret key that can be extracted from the raw statistics depends strongly on this quantity since it affects in particular the computation of the excess noise (i.e., noise in excess of the shot noise) added by an eavesdropper on the quantum channel. Some powerful quantum hacking attacks relying on faking the estimated value of the shot noise to hide an intercept and resend strategy were proposed. Here, we provide experimental evidence that our method can defeat the saturation attack and the wavelength attack.

Continuous-variable quantum cryptography with an untrusted relay: Detailed security analysis of the symmetric configuration

NASA Astrophysics Data System (ADS)

Ottaviani, Carlo; Spedalieri, Gaetana; Braunstein, Samuel L.; Pirandola, Stefano

2015-02-01

We consider the continuous-variable protocol of Pirandola et al. [arXiv:1312.4104] where the secret key is established by the measurement of an untrusted relay. In this network protocol, two authorized parties are connected to an untrusted relay by insecure quantum links. Secret correlations are generated by a continuous-variable Bell detection performed on incoming coherent states. In the present work we provide a detailed study of the symmetric configuration, where the relay is midway between the parties. We analyze symmetric eavesdropping strategies against the quantum links explicitly showing that, at fixed transmissivity and thermal noise, two-mode coherent attacks are optimal, manifestly outperforming one-mode collective attacks based on independent entangling cloners. Such an advantage is shown both in terms of security threshold and secret-key rate.

Continuous but diverse advancement of spring-summer phenology in response to climate warming across the Qinghai-Tibetan Plateau

DOE PAGES

Zheng, Zhoutao; Zhu, Wenquan; Chen, Guangsheng; ...

2016-04-25

The Qinghai-Tibetan Plateau (QTP) is more vulnerable and sensitive to climate change than many other regions worldwide because of its high altitude, permafrost geography, and harsh physical environment. As a sensitive bio-indicator of climate change, plant phenology shift in this region has been intensively studied during the recent decades, primarily based on satellite-retrieved data. However, great controversy still exists regarding the change in direction and magnitudes of spring-summer phenology. Based on a large number (11,000+ records) of long-term and continuous ground observational data for various plant species, our study intended to more comprehensively assess the changing trends of spring-summer phenologymore » and their relationships with climatic change across the QTP. The results indicated a continuous advancement (–2.69 days decade –1) in spring-summer phenology from 1981 to 2011, with an even more rapid advancement during 2000–2011 (–3.13 days decade –1), which provided new field evidence for continuous advancement in spring-summer phenology across the QTP. However, diverse advancing rates in spring-summer phenology were observed for different vegetation types, thermal conditions, and seasons. The advancing trends matched well with the difference in sensitivity of spring-summer phenology to increasing temperature, implying that the sensitivity of phenology to temperature was one of the major factors influencing spring-summer phenology shifts. Besides, increased precipitation could advance the spring-summer phenology. As a result, the response of spring-summer phenology to temperature tended to be stronger from east to west across all species, while the response to precipitation showed no consistent spatial pattern.« less

Continuous but diverse advancement of spring-summer phenology in response to climate warming across the Qinghai-Tibetan Plateau

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zheng, Zhoutao; Zhu, Wenquan; Chen, Guangsheng

The Qinghai-Tibetan Plateau (QTP) is more vulnerable and sensitive to climate change than many other regions worldwide because of its high altitude, permafrost geography, and harsh physical environment. As a sensitive bio-indicator of climate change, plant phenology shift in this region has been intensively studied during the recent decades, primarily based on satellite-retrieved data. However, great controversy still exists regarding the change in direction and magnitudes of spring-summer phenology. Based on a large number (11,000+ records) of long-term and continuous ground observational data for various plant species, our study intended to more comprehensively assess the changing trends of spring-summer phenologymore » and their relationships with climatic change across the QTP. The results indicated a continuous advancement (–2.69 days decade –1) in spring-summer phenology from 1981 to 2011, with an even more rapid advancement during 2000–2011 (–3.13 days decade –1), which provided new field evidence for continuous advancement in spring-summer phenology across the QTP. However, diverse advancing rates in spring-summer phenology were observed for different vegetation types, thermal conditions, and seasons. The advancing trends matched well with the difference in sensitivity of spring-summer phenology to increasing temperature, implying that the sensitivity of phenology to temperature was one of the major factors influencing spring-summer phenology shifts. Besides, increased precipitation could advance the spring-summer phenology. As a result, the response of spring-summer phenology to temperature tended to be stronger from east to west across all species, while the response to precipitation showed no consistent spatial pattern.« less

Fault-tolerant measurement-based quantum computing with continuous-variable cluster states.

PubMed

Menicucci, Nicolas C

2014-03-28

A long-standing open question about Gaussian continuous-variable cluster states is whether they enable fault-tolerant measurement-based quantum computation. The answer is yes. Initial squeezing in the cluster above a threshold value of 20.5 dB ensures that errors from finite squeezing acting on encoded qubits are below the fault-tolerance threshold of known qubit-based error-correcting codes. By concatenating with one of these codes and using ancilla-based error correction, fault-tolerant measurement-based quantum computation of theoretically indefinite length is possible with finitely squeezed cluster states.

Unconditional optimality of Gaussian attacks against continuous-variable quantum key distribution.

PubMed

García-Patrón, Raúl; Cerf, Nicolas J

2006-11-10

A fully general approach to the security analysis of continuous-variable quantum key distribution (CV-QKD) is presented. Provided that the quantum channel is estimated via the covariance matrix of the quadratures, Gaussian attacks are shown to be optimal against all collective eavesdropping strategies. The proof is made strikingly simple by combining a physical model of measurement, an entanglement-based description of CV-QKD, and a recent powerful result on the extremality of Gaussian states [M. M. Wolf, Phys. Rev. Lett. 96, 080502 (2006)10.1103/PhysRevLett.96.080502].

Anonymous broadcasting of classical information with a continuous-variable topological quantum code

NASA Astrophysics Data System (ADS)

Menicucci, Nicolas C.; Baragiola, Ben Q.; Demarie, Tommaso F.; Brennen, Gavin K.

2018-03-01

Broadcasting information anonymously becomes more difficult as surveillance technology improves, but remarkably, quantum protocols exist that enable provably traceless broadcasting. The difficulty is making scalable entangled resource states that are robust to errors. We propose an anonymous broadcasting protocol that uses a continuous-variable surface-code state that can be produced using current technology. High squeezing enables large transmission bandwidth and strong anonymity, and the topological nature of the state enables local error mitigation.

Minimum fuel control of a vehicle with a continuously variable transmission. [control system simulation

NASA Technical Reports Server (NTRS)

Burghart, J. H.; Donoghue, J. F.

1980-01-01

The design and evaluation of a control system for a sedan with a heat engine and a continuously variable transmission, is considered in a effort to minimize fuel consumption and achieve satisfactory dynamic response of vehicle variables as the vehicle is driven over a standard driving cycle. Even though the vehicle system was highly nonlinear, attention was restricted to linear control algorithms which could be easily understood and implemented demonstrated by simulation. Simulation results also revealed that the vehicle could exhibit unexpected dynamic behavior which must be taken into account in any control system design.

Unconditional security proof of long-distance continuous-variable quantum key distribution with discrete modulation.

PubMed

Leverrier, Anthony; Grangier, Philippe

2009-05-08

We present a continuous-variable quantum key distribution protocol combining a discrete modulation and reverse reconciliation. This protocol is proven unconditionally secure and allows the distribution of secret keys over long distances, thanks to a reverse reconciliation scheme efficient at very low signal-to-noise ratio.

Detecting faked continuous-variable entanglement using one-sided device-independent entanglement witnesses

NASA Astrophysics Data System (ADS)

Opanchuk, B.; Arnaud, L.; Reid, M. D.

2014-06-01

We demonstrate the principle of one-sided device-independent continuous-variable (CV) quantum information. In situations of no trust, we show by enactment how the use of standard CV entanglement criteria can mislead Charlie into thinking that Alice and Bob share entanglement, when the data are actually generated classically using a local-hidden-variable theory based on the Wigner function. We distinguish between criteria that demonstrate CV entanglement, and criteria that demonstrate the CV Einstein-Podolsky-Rosen (EPR) steering paradox. We show that the latter, but not the former, are necessarily one-sided device-independent entanglement witnesses, and can be used by Charlie to signify genuine EPR entanglement, if he trusts only Alice. A monogamy result for the EPR steering paradox confirms the security of the shared amplitude values in that case.

Variable Camber Continuous Aerodynamic Control Surfaces and Methods for Active Wing Shaping Control

NASA Technical Reports Server (NTRS)

Nguyen, Nhan T. (Inventor)

2016-01-01

An aerodynamic control apparatus for an air vehicle improves various aerodynamic performance metrics by employing multiple spanwise flap segments that jointly form a continuous or a piecewise continuous trailing edge to minimize drag induced by lift or vortices. At least one of the multiple spanwise flap segments includes a variable camber flap subsystem having multiple chordwise flap segments that may be independently actuated. Some embodiments also employ a continuous leading edge slat system that includes multiple spanwise slat segments, each of which has one or more chordwise slat segment. A method and an apparatus for implementing active control of a wing shape are also described and include the determination of desired lift distribution to determine the improved aerodynamic deflection of the wings. Flap deflections are determined and control signals are generated to actively control the wing shape to approximate the desired deflection.

Implementation of continuous-variable quantum key distribution with composable and one-sided-device-independent security against coherent attacks.

PubMed

Gehring, Tobias; Händchen, Vitus; Duhme, Jörg; Furrer, Fabian; Franz, Torsten; Pacher, Christoph; Werner, Reinhard F; Schnabel, Roman

2015-10-30

Secret communication over public channels is one of the central pillars of a modern information society. Using quantum key distribution this is achieved without relying on the hardness of mathematical problems, which might be compromised by improved algorithms or by future quantum computers. State-of-the-art quantum key distribution requires composable security against coherent attacks for a finite number of distributed quantum states as well as robustness against implementation side channels. Here we present an implementation of continuous-variable quantum key distribution satisfying these requirements. Our implementation is based on the distribution of continuous-variable Einstein-Podolsky-Rosen entangled light. It is one-sided device independent, which means the security of the generated key is independent of any memoryfree attacks on the remote detector. Since continuous-variable encoding is compatible with conventional optical communication technology, our work is a step towards practical implementations of quantum key distribution with state-of-the-art security based solely on telecom components.

Implementation of continuous-variable quantum key distribution with composable and one-sided-device-independent security against coherent attacks

PubMed Central

Gehring, Tobias; Händchen, Vitus; Duhme, Jörg; Furrer, Fabian; Franz, Torsten; Pacher, Christoph; Werner, Reinhard F.; Schnabel, Roman

2015-01-01

Secret communication over public channels is one of the central pillars of a modern information society. Using quantum key distribution this is achieved without relying on the hardness of mathematical problems, which might be compromised by improved algorithms or by future quantum computers. State-of-the-art quantum key distribution requires composable security against coherent attacks for a finite number of distributed quantum states as well as robustness against implementation side channels. Here we present an implementation of continuous-variable quantum key distribution satisfying these requirements. Our implementation is based on the distribution of continuous-variable Einstein–Podolsky–Rosen entangled light. It is one-sided device independent, which means the security of the generated key is independent of any memoryfree attacks on the remote detector. Since continuous-variable encoding is compatible with conventional optical communication technology, our work is a step towards practical implementations of quantum key distribution with state-of-the-art security based solely on telecom components. PMID:26514280

Variability, trends, and predictability of seasonal sea ice retreat and advance in the Chukchi Sea

NASA Astrophysics Data System (ADS)

Serreze, Mark C.; Crawford, Alex D.; Stroeve, Julienne C.; Barrett, Andrew P.; Woodgate, Rebecca A.

2016-10-01

As assessed over the period 1979-2014, the date that sea ice retreats to the shelf break (150 m contour) of the Chukchi Sea has a linear trend of -0.7 days per year. The date of seasonal ice advance back to the shelf break has a steeper trend of about +1.5 days per year, together yielding an increase in the open water period of 80 days. Based on detrended time series, we ask how interannual variability in advance and retreat dates relate to various forcing parameters including radiation fluxes, temperature and wind (from numerical reanalyses), and the oceanic heat inflow through the Bering Strait (from in situ moorings). Of all variables considered, the retreat date is most strongly correlated (r ˜ 0.8) with the April through June Bering Strait heat inflow. After testing a suite of statistical linear models using several potential predictors, the best model for predicting the date of retreat includes only the April through June Bering Strait heat inflow, which explains 68% of retreat date variance. The best model predicting the ice advance date includes the July through September inflow and the date of retreat, explaining 67% of advance date variance. We address these relationships by discussing heat balances within the Chukchi Sea, and the hypothesis of oceanic heat transport triggering ocean heat uptake and ice-albedo feedback. Developing an operational prediction scheme for seasonal retreat and advance would require timely acquisition of Bering Strait heat inflow data. Predictability will likely always be limited by the chaotic nature of atmospheric circulation patterns.

Field demonstration of a continuous-variable quantum key distribution network.

PubMed

Huang, Duan; Huang, Peng; Li, Huasheng; Wang, Tao; Zhou, Yingming; Zeng, Guihua

2016-08-01

We report on what we believe is the first field implementation of a continuous-variable quantum key distribution (CV-QKD) network with point-to-point configuration. Four QKD nodes are deployed on standard communication infrastructures connected with commercial telecom optical fiber. Reliable key exchange is achieved in the wavelength-division-multiplexing CV-QKD network. The impact of a complex and volatile field environment on the excess noise is investigated, since excess noise controlling and reduction is arguably the major issue pertaining to distance and the secure key rate. We confirm the applicability and verify the maturity of the CV-QKD network in a metropolitan area, thus paving the way for a next-generation global secure communication network.

Cost-effectiveness of continuation maintenance pemetrexed after cisplatin and pemetrexed chemotherapy for advanced nonsquamous non-small-cell lung cancer: estimates from the perspective of the Chinese health care system.

PubMed

Zeng, Xiaohui; Peng, Liubao; Li, Jianhe; Chen, Gannong; Tan, Chongqing; Wang, Siying; Wan, Xiaomin; Ouyang, Lihui; Zhao, Ziying

2013-01-01

Continuation maintenance treatment with pemetrexed is approved by current clinical guidelines as a category 2A recommendation after induction therapy with cisplatin and pemetrexed chemotherapy (CP strategy) for patients with advanced nonsquamous non-small-cell lung cancer (NSCLC). However, the cost-effectiveness of the treatment remains unclear. We completed a trial-based assessment, from the perspective of the Chinese health care system, of the cost-effectiveness of maintenance pemetrexed treatment after a CP strategy for patients with advanced nonsquamous NSCLC. A Markov model was developed to estimate costs and benefits. It was based on a clinical trial that compared continuation maintenance pemetrexed therapy plus best supportive care (BSC) versus placebo plus BSC after a CP strategy for advanced nonsquamous NSCLC. Sensitivity analyses were conducted to assess the stability of the model. The model base case analysis suggested that continuation maintenance pemetrexed therapy after a CP strategy would increase benefits in a 1-, 2-, 5-, or 10-year time horizon, with incremental costs of $183,589.06, $126,353.16, $124,766.68, and $124,793.12 per quality-adjusted life-year gained, respectively. The most sensitive influential variable in the cost-effectiveness analysis was the utility of the progression-free survival state, followed by proportion of patients with postdiscontinuation therapy in both arms, proportion of BSC costs for PFS versus progressed survival state, and cost of pemetrexed. Probabilistic sensitivity analysis indicated that the cost-effective probability of adding continuation maintenance pemetrexed therapy to BSC was zero. One-way and probabilistic sensitivity analyses revealed that the Markov model was robust. Continuation maintenance of pemetrexed after a CP strategy for patients with advanced nonsquamous NSCLC is not cost-effective based on a recent clinical trial. Decreasing the price or adjusting the dosage of pemetrexed may be a better option

Quantifying non-Markovianity of continuous-variable Gaussian dynamical maps

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vasile, Ruggero; Maniscalco, Sabrina; Paris, Matteo G. A.

2011-11-15

We introduce a non-Markovianity measure for continuous-variable open quantum systems based on the idea put forward in H.-P. Breuer et al.[Phys. Rev. Lett. 103, 210401 (2009);], that is, by quantifying the flow of information from the environment back to the open system. Instead of the trace distance we use here the fidelity to assess distinguishability of quantum states. We employ our measure to evaluate non-Markovianity of two paradigmatic Gaussian channels: the purely damping channel and the quantum Brownian motion channel with Ohmic environment. We consider different classes of Gaussian states and look for pairs of states maximizing the backflow ofmore » information. For coherent states we find simple analytical solutions, whereas for squeezed states we provide both exact numerical and approximate analytical solutions in the weak coupling limit.« less

Simple proof of the quantum benchmark fidelity for continuous-variable quantum devices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Namiki, Ryo

2011-04-15

An experimental success criterion for continuous-variable quantum teleportation and memory is to surpass the limit of the average fidelity achieved by classical measure-and-prepare schemes with respect to a Gaussian-distributed set of coherent states. We present an alternative proof of the classical limit based on the familiar notions of state-channel duality and partial transposition. The present method enables us to produce a quantum-domain criterion associated with a given set of measured fidelities.

Coherent attacking continuous-variable quantum key distribution with entanglement in the middle

NASA Astrophysics Data System (ADS)

Zhang, Zhaoyuan; Shi, Ronghua; Zeng, Guihua; Guo, Ying

2018-06-01

We suggest an approach on the coherent attack of continuous-variable quantum key distribution (CVQKD) with an untrusted entangled source in the middle. The coherent attack strategy can be performed on the double links of quantum system, enabling the eavesdropper to steal more information from the proposed scheme using the entanglement correlation. Numeric simulation results show the improved performance of the attacked CVQKD system in terms of the derived secret key rate with the controllable parameters maximizing the stolen information.

Characters of Vertical Variability with Geodetic Satellites and Ground-based Continuous GPS in Taiwan

NASA Astrophysics Data System (ADS)

Yang, C.-C.; Wu, Y.-H.; Chao, B. F.; Yu, S.-B.

2009-04-01

Present-day GPS network have been extensively used to monitor crustal deformation due to various geodynamic mechanisms. Situated among the Pacific Ring of Fire on the suture zone of Eurasian and Philippine Sea Plates, the island of Taiwan with a dense continuous GPS network since ~1996 and now over 300 stations sees plenty of geophysical phenomena including particularly prominent crustal motions. We assessed daily solution of each station's coordinate time series, and made the routine corrections, such as orbital, EOP, atmospheric and tidal corrections, using GAMIT/GLOBK software (with ITRF05). We then employ the Quasi-Observation Combination Analysis (QOCA) package to obtain the variability and trend after removing occasional earthquake "disruptions". Preliminary results show strong seasonal variations. We then utilize the numerical method of Empirical Orthogonal Function (EOF) to analysis the geophysical signals from the continuous and dense GPS vertical crustal motion observations. We wish to be able to characterize both the seasonal and non-seasonal variability in the vertical crustal motion, in terms of the EOF modes in the spatial domain over Taiwan (plus a few offshore islets) with time evolution spanning the entire period of time. Corraborating with time-variable gravity data from the geodetic satellite mission GRACE, we can further obtain vertical components of both mass-induced loading with respect to the precipitation minus evaporation and the crustal motion caused by the active tectonic processes on Taiwan.

Quantum key distribution using continuous-variable non-Gaussian states

NASA Astrophysics Data System (ADS)

Borelli, L. F. M.; Aguiar, L. S.; Roversi, J. A.; Vidiella-Barranco, A.

2016-02-01

In this work, we present a quantum key distribution protocol using continuous-variable non-Gaussian states, homodyne detection and post-selection. The employed signal states are the photon added then subtracted coherent states (PASCS) in which one photon is added and subsequently one photon is subtracted from the field. We analyze the performance of our protocol, compared with a coherent state-based protocol, for two different attacks that could be carried out by the eavesdropper (Eve). We calculate the secret key rate transmission in a lossy line for a superior channel (beam-splitter) attack, and we show that we may increase the secret key generation rate by using the non-Gaussian PASCS rather than coherent states. We also consider the simultaneous quadrature measurement (intercept-resend) attack, and we show that the efficiency of Eve's attack is substantially reduced if PASCS are used as signal states.

Quantum frequency up-conversion of continuous variable entangled states

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Wenyuan; Wang, Ning; Li, Zongyang

We demonstrate experimentally quantum frequency up-conversion of a continuous variable entangled optical field via sum-frequency-generation process. The two-color entangled state initially entangled at 806 and 1518 nm with an amplitude quadrature difference squeezing of 3.2 dB and phase quadrature sum squeezing of 3.1 dB is converted to a new entangled state at 530 and 1518 nm with the amplitude quadrature difference squeezing of 1.7 dB and phase quadrature sum squeezing of 1.8 dB. Our implementation enables the observation of entanglement between two light fields spanning approximately 1.5 octaves in optical frequency. The presented scheme is robust to the excess amplitude and phase noises of the pumpmore » field, making it a practical building block for quantum information processing and communication networks.« less

Optimal continuous variable quantum teleportation protocol for realistic settings

NASA Astrophysics Data System (ADS)

Luiz, F. S.; Rigolin, Gustavo

2015-03-01

We show the optimal setup that allows Alice to teleport coherent states | α > to Bob giving the greatest fidelity (efficiency) when one takes into account two realistic assumptions. The first one is the fact that in any actual implementation of the continuous variable teleportation protocol (CVTP) Alice and Bob necessarily share non-maximally entangled states (two-mode finitely squeezed states). The second one assumes that Alice's pool of possible coherent states to be teleported to Bob does not cover the whole complex plane (| α | < ∞). The optimal strategy is achieved by tuning three parameters in the original CVTP, namely, Alice's beam splitter transmittance and Bob's displacements in position and momentum implemented on the teleported state. These slight changes in the protocol are currently easy to be implemented and, as we show, give considerable gain in performance for a variety of possible pool of input states with Alice.

Notes on a Continuous-Variable Quantum Key Distribution Scheme

NASA Astrophysics Data System (ADS)

Ichikawa, Tsubasa; Hirano, Takuya; Matsubara, Takuto; Ono, Motoharu; Namiki, Ryo

2017-09-01

We develop a physical model to describe the signal transmission for a continuous-variable quantum key distribution scheme and investigate its security against a couple of eavesdropping attacks assuming that the eavesdropper's power is partly restricted owing to today's technological limitations. We consider an eavesdropper performing quantum optical homodyne measurement on the signal obtained by a type of beamsplitting attack. We also consider the case in which the eavesdropper Eve is unable to access a quantum memory and she performs heterodyne measurement on her signal without performing a delayed measurement. Our formulation includes a model in which the receiver's loss and noise are unaccessible by the eavesdropper. This setup enables us to investigate the condition that Eve uses a practical fiber differently from the usual beamsplitting attack where she can deploy a lossless transmission channel. The secret key rates are calculated in both the direct and reverse reconciliation scenarios.

Design studies of continuously variable transmissions for electric vehicles

NASA Technical Reports Server (NTRS)

Parker, R. J.; Loewenthal, S. H.; Fischer, G. K.

1981-01-01

Preliminary design studies were performed on four continuously variable transmission (CVT) concepts for use with a flywheel equipped electric vehicle of 1700 kg gross weight. Requirements of the CVT's were a maximum torque of 450 N-m (330 lb-ft), a maximum output power of 75 kW (100 hp), and a flywheel speed range of 28,000 to 14,000 rpm. Efficiency, size, weight, cost, reliability, maintainability, and controls were evaluated for each of the four concepts which included a steel V-belt type, a flat rubber belt type, a toroidal traction type, and a cone roller traction type. All CVT's exhibited relatively high calculated efficiencies (68 percent to 97 percent) over a broad range of vehicle operating conditions. Estimated weight and size of these transmissions were comparable to or less than equivalent automatic transmission. The design of each concept was carried through the design layout stage.

Experimental study on discretely modulated continuous-variable quantum key distribution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shen Yong; Zou Hongxin; Chen Pingxing

2010-08-15

We present a discretely modulated continuous-variable quantum key distribution system in free space by using strong coherent states. The amplitude noise in the laser source is suppressed to the shot-noise limit by using a mode cleaner combined with a frequency shift technique. Also, it is proven that the phase noise in the source has no impact on the final secret key rate. In order to increase the encoding rate, we use broadband homodyne detectors and the no-switching protocol. In a realistic model, we establish a secret key rate of 46.8 kbits/s against collective attacks at an encoding rate of 10more » MHz for a 90% channel loss when the modulation variance is optimal.« less

Security of Continuous-Variable Quantum Key Distribution via a Gaussian de Finetti Reduction

NASA Astrophysics Data System (ADS)

Leverrier, Anthony

2017-05-01

Establishing the security of continuous-variable quantum key distribution against general attacks in a realistic finite-size regime is an outstanding open problem in the field of theoretical quantum cryptography if we restrict our attention to protocols that rely on the exchange of coherent states. Indeed, techniques based on the uncertainty principle are not known to work for such protocols, and the usual tools based on de Finetti reductions only provide security for unrealistically large block lengths. We address this problem here by considering a new type of Gaussian de Finetti reduction, that exploits the invariance of some continuous-variable protocols under the action of the unitary group U (n ) (instead of the symmetric group Sn as in usual de Finetti theorems), and by introducing generalized S U (2 ,2 ) coherent states. Crucially, combined with an energy test, this allows us to truncate the Hilbert space globally instead as at the single-mode level as in previous approaches that failed to provide security in realistic conditions. Our reduction shows that it is sufficient to prove the security of these protocols against Gaussian collective attacks in order to obtain security against general attacks, thereby confirming rigorously the widely held belief that Gaussian attacks are indeed optimal against such protocols.

Security of Continuous-Variable Quantum Key Distribution via a Gaussian de Finetti Reduction.

PubMed

Leverrier, Anthony

2017-05-19

Establishing the security of continuous-variable quantum key distribution against general attacks in a realistic finite-size regime is an outstanding open problem in the field of theoretical quantum cryptography if we restrict our attention to protocols that rely on the exchange of coherent states. Indeed, techniques based on the uncertainty principle are not known to work for such protocols, and the usual tools based on de Finetti reductions only provide security for unrealistically large block lengths. We address this problem here by considering a new type of Gaussian de Finetti reduction, that exploits the invariance of some continuous-variable protocols under the action of the unitary group U(n) (instead of the symmetric group S_{n} as in usual de Finetti theorems), and by introducing generalized SU(2,2) coherent states. Crucially, combined with an energy test, this allows us to truncate the Hilbert space globally instead as at the single-mode level as in previous approaches that failed to provide security in realistic conditions. Our reduction shows that it is sufficient to prove the security of these protocols against Gaussian collective attacks in order to obtain security against general attacks, thereby confirming rigorously the widely held belief that Gaussian attacks are indeed optimal against such protocols.

High-efficiency Gaussian key reconciliation in continuous variable quantum key distribution

NASA Astrophysics Data System (ADS)

Bai, ZengLiang; Wang, XuYang; Yang, ShenShen; Li, YongMin

2016-01-01

Efficient reconciliation is a crucial step in continuous variable quantum key distribution. The progressive-edge-growth (PEG) algorithm is an efficient method to construct relatively short block length low-density parity-check (LDPC) codes. The qua-sicyclic construction method can extend short block length codes and further eliminate the shortest cycle. In this paper, by combining the PEG algorithm and qua-si-cyclic construction method, we design long block length irregular LDPC codes with high error-correcting capacity. Based on these LDPC codes, we achieve high-efficiency Gaussian key reconciliation with slice recon-ciliation based on multilevel coding/multistage decoding with an efficiency of 93.7%.

High performance frame synchronization for continuous variable quantum key distribution systems.

PubMed

Lin, Dakai; Huang, Peng; Huang, Duan; Wang, Chao; Peng, Jinye; Zeng, Guihua

2015-08-24

Considering a practical continuous variable quantum key distribution(CVQKD) system, synchronization is of significant importance as it is hardly possible to extract secret keys from unsynchronized strings. In this paper, we proposed a high performance frame synchronization method for CVQKD systems which is capable to operate under low signal-to-noise(SNR) ratios and is compatible with random phase shift induced by quantum channel. A practical implementation of this method with low complexity is presented and its performance is analysed. By adjusting the length of synchronization frame, this method can work well with large range of SNR values which paves the way for longer distance CVQKD.

Collective attacks and unconditional security in continuous variable quantum key distribution.

PubMed

Grosshans, Frédéric

2005-01-21

We present here an information theoretic study of Gaussian collective attacks on the continuous variable key distribution protocols based on Gaussian modulation of coherent states. These attacks, overlooked in previous security studies, give a finite advantage to the eavesdropper in the experimentally relevant lossy channel, but are not powerful enough to reduce the range of the reverse reconciliation protocols. Secret key rates are given for the ideal case where Bob performs optimal collective measurements, as well as for the realistic cases where he performs homodyne or heterodyne measurements. We also apply the generic security proof of Christiandl et al. to obtain unconditionally secure rates for these protocols.

Continuous variables logic via coupled automata using a DNAzyme cascade with feedback.

PubMed

Lilienthal, S; Klein, M; Orbach, R; Willner, I; Remacle, F; Levine, R D

2017-03-01

The concentration of molecules can be changed by chemical reactions and thereby offer a continuous readout. Yet computer architecture is cast in textbooks in terms of binary valued, Boolean variables. To enable reactive chemical systems to compute we show how, using the Cox interpretation of probability theory, one can transcribe the equations of chemical kinetics as a sequence of coupled logic gates operating on continuous variables. It is discussed how the distinct chemical identity of a molecule allows us to create a common language for chemical kinetics and Boolean logic. Specifically, the logic AND operation is shown to be equivalent to a bimolecular process. The logic XOR operation represents chemical processes that take place concurrently. The values of the rate constants enter the logic scheme as inputs. By designing a reaction scheme with a feedback we endow the logic gates with a built in memory because their output then depends on the input and also on the present state of the system. Technically such a logic machine is an automaton. We report an experimental realization of three such coupled automata using a DNAzyme multilayer signaling cascade. A simple model verifies analytically that our experimental scheme provides an integrator generating a power series that is third order in time. The model identifies two parameters that govern the kinetics and shows how the initial concentrations of the substrates are the coefficients in the power series.

Continuous variable quantum key distribution with a real local oscillator using simultaneous pilot signals.

PubMed

Kleis, Sebastian; Rueckmann, Max; Schaeffer, Christian G

2017-04-15

In this Letter, we propose a novel implementation of continuous variable quantum key distribution that operates with a real local oscillator placed at the receiver site. In addition, pulsing of the continuous wave laser sources is not required, leading to an extraordinary practical and secure setup. It is suitable for arbitrary schemes based on modulated coherent states and heterodyne detection. The shown results include transmission experiments, as well as an excess noise analysis applying a discrete 8-state phase modulation. Achievable key rates under collective attacks are estimated. The results demonstrate the high potential of the approach to achieve high secret key rates at relatively low effort and cost.

Teleportation of a Kind of Three-Mode Entangled States of Continuous Variables

NASA Astrophysics Data System (ADS)

Fan, Hong-Yi; Liang, Xian-Ting

2005-11-01

A quantum teleportation scheme to teleport a kind of tripartite entangled states of continuous variables by using a quantum channel composed of three bipartite entangled states is proposed. The joint Bell measurement is feasible because the bipartite entangled states are complete and the squeezed state has a natural representation in the entangled state basis. The calculation is greatly simplified by using the Schmidt decomposition of the entangled states. The project supported by the President Funds of the Chinese Academy of Sciences and National Natural Science Foundation of China under Grant No. 10475056

High-speed continuous-variable quantum key distribution without sending a local oscillator.

PubMed

Huang, Duan; Huang, Peng; Lin, Dakai; Wang, Chao; Zeng, Guihua

2015-08-15

We report a 100-MHz continuous-variable quantum key distribution (CV-QKD) experiment over a 25-km fiber channel without sending a local oscillator (LO). We use a "locally" generated LO and implement with a 1-GHz shot-noise-limited homodyne detector to achieve high-speed quantum measurement, and we propose a secure phase compensation scheme to maintain a low level of excess noise. These make high-bit-rate CV-QKD significantly simpler for larger transmission distances compared with previous schemes in which both LO and quantum signals are transmitted through the insecure quantum channel.

Influence of continuous haemofiltration-related hypothermia on haemodynamic variables and gas exchange in septic patients.

PubMed

Matamis, D; Tsagourias, M; Koletsos, K; Riggos, D; Mavromatidis, K; Sombolos, K; Bursztein, S

1994-07-01

To investigate the influence of continuous haemofiltration (CHF) on haemodynamics, gas exchange and core temperature in critically ill septic patients with acute renal failure. In 20 patients (17 male, 3 female) ultrafiltration rate, core temperature, gas exchange and haemodynamic variables were measured at regular intervals during the first 48 h of haemofiltration. Baseline data were compared to those obtained 30 min after initiating CHF and also to those during hypothermia (if observed). Haemodynamic variables remained remarkably constant throughout the study period. In patients with a relatively low ultrafiltration rate (855 +/- 278 ml/h) temperature did not change, while in patients with a high ultrafiltration rate (1468 +/- 293 ml/h) core temperature significantly decreased from 37.6 +/- 0.9 degrees C to 34.8 +/- 0.8 degrees C (p < 0.001). There was a statistically significant correlation between temperature decrease and ultrafiltration rate (r = -0.68, Y = 1.8-0.003 X, p < 0.01). Hypothermic patients also showed a mean decrease in VO2 from 141 +/- 22 ml/min/m2 to 112 +/- 22 ml/min/m2 (p < 0.01) with a concomitant increase in PaO2 from 103 +/- 37 mmHg to 140 +/- 42 mmHg (p < 0.001) and in PvO2 from 35 +/- 4 mmHg to 41 +/- 5 mmHg (p < 0.001). 1) Continuous haemofiltration does not cause significant alternations in haemodynamic variables. 2) Hypothermia frequently occurs in patients undergoing continuous haemofiltration with high ultrafiltration rates. These hypothermic patients show a reduction in VO2 leading to an increase in PvO2 and PaO2. This mild hypothermia in these circumstances has no evident deleterious effects.

Ancilla-driven quantum computation for qudits and continuous variables

NASA Astrophysics Data System (ADS)

Proctor, Timothy; Giulian, Melissa; Korolkova, Natalia; Andersson, Erika; Kendon, Viv

2017-05-01

Although qubits are the leading candidate for the basic elements in a quantum computer, there are also a range of reasons to consider using higher-dimensional qudits or quantum continuous variables (QCVs). In this paper, we use a general "quantum variable" formalism to propose a method of quantum computation in which ancillas are used to mediate gates on a well-isolated "quantum memory" register and which may be applied to the setting of qubits, qudits (for d >2 ), or QCVs. More specifically, we present a model in which universal quantum computation may be implemented on a register using only repeated applications of a single fixed two-body ancilla-register interaction gate, ancillas prepared in a single state, and local measurements of these ancillas. In order to maintain determinism in the computation, adaptive measurements via a classical feed forward of measurement outcomes are used, with the method similar to that in measurement-based quantum computation (MBQC). We show that our model has the same hybrid quantum-classical processing advantages as MBQC, including the power to implement any Clifford circuit in essentially one layer of quantum computation. In some physical settings, high-quality measurements of the ancillas may be highly challenging or not possible, and hence we also present a globally unitary model which replaces the need for measurements of the ancillas with the requirement for ancillas to be prepared in states from a fixed orthonormal basis. Finally, we discuss settings in which these models may be of practical interest.

Observation of strong continuous-variable Einstein-Podolsky-Rosen entanglement using shaped local oscillators

NASA Astrophysics Data System (ADS)

Shinjo, Ami; Hashiyama, Naoyuki; Koshio, Akane; Eto, Yujiro; Hirano, Takuya

2016-10-01

The continuous-variable (CV) Einstein-Podolsky-Rosen (EPR) paradox and steering are demonstrated using a pulsed light source and waveguides. We shorten the duration of the local oscillator (LO) pulse by using parametric amplification to improve the temporal mode-matching between the entangled pulse and the LO pulse. After correcting for the amplifier noise, the product of the measured conditional variance of the quadrature-phase amplitudes is 0.74 < 1, which satisfies the EPR-Reid criterion.

Comparison of the effects of continuous positive airway pressure and mandibular advancement devices on sleepiness in patients with obstructive sleep apnoea: a network meta-analysis.

PubMed

Bratton, Daniel J; Gaisl, Thomas; Schlatzer, Christian; Kohler, Malcolm

2015-11-01

Excessive daytime sleepiness is the most important symptom of obstructive sleep apnoea and can affect work productivity, quality of life, and the risk of road traffic accidents. We aimed to quantify the effects of the two main treatments for obstructive sleep apnoea (continuous positive airway pressure and mandibular advancement devices) on daytime sleepiness and to establish predictors of response to continuous positive airway pressure. We searched MEDLINE and the Cochrane Library from inception to May 31, 2015, to identify randomised controlled trials comparing the effects of continuous positive airway pressure, mandibular advancement devices or an inactive control (eg, placebo or no treatment) on the Epworth Sleepiness Scale (ESS, range 0-24 points) in patients with obstructive sleep apnoea. We did a network meta-analysis using multivariate random-effects meta-regression to assess the effect of each treatment on ESS. We used meta-regression to assess the association of the reported effects of continuous positive airway pressure versus inactive controls with the characteristics of trials and their risk of bias. We included 67 studies comprising 6873 patients in the meta-analysis. Compared with an inactive control, continuous positive airway pressure was associated with a reduction in ESS score of 2·5 points (95% CI 2·0-2·9) and mandibular advancement devices of 1·7 points (1·1-2·3). We estimated that, on average, continuous positive airway pressure reduced the ESS score by a further 0·8 points compared with mandibular advancement devices (95% CI 0·1-1·4; p=0·015). However, there was a possibility of publication bias in favour of continuous positive airway pressure that might have resulted in this difference. We noted no evidence that studies reporting higher continuous positive airway pressure adherence also reported larger treatment effects (p=0·70). Continuous positive airway pressure and mandibular advancement devices are effective treatments for

Violation of continuous-variable Einstein-Podolsky-Rosen steering with discrete measurements.

PubMed

Schneeloch, James; Dixon, P Ben; Howland, Gregory A; Broadbent, Curtis J; Howell, John C

2013-03-29

In this Letter, we derive an entropic Einstein-Podolsky-Rosen (EPR) steering inequality for continuous-variable systems using only experimentally measured discrete probability distributions and details of the measurement apparatus. We use this inequality to witness EPR steering between the positions and momenta of photon pairs generated in spontaneous parametric down-conversion. We examine the asymmetry between parties in this inequality, and show that this asymmetry can be used to reduce the technical requirements of experimental setups intended to demonstrate the EPR paradox. Furthermore, we develop a more stringent steering inequality that is symmetric between parties, and use it to show that the down-converted photon pairs also exhibit symmetric EPR steering.

Violation of Continuous-Variable Einstein-Podolsky-Rosen Steering with Discrete Measurements

NASA Astrophysics Data System (ADS)

Schneeloch, James; Dixon, P. Ben; Howland, Gregory A.; Broadbent, Curtis J.; Howell, John C.

2013-03-01

In this Letter, we derive an entropic Einstein-Podolsky-Rosen (EPR) steering inequality for continuous-variable systems using only experimentally measured discrete probability distributions and details of the measurement apparatus. We use this inequality to witness EPR steering between the positions and momenta of photon pairs generated in spontaneous parametric down-conversion. We examine the asymmetry between parties in this inequality, and show that this asymmetry can be used to reduce the technical requirements of experimental setups intended to demonstrate the EPR paradox. Furthermore, we develop a more stringent steering inequality that is symmetric between parties, and use it to show that the down-converted photon pairs also exhibit symmetric EPR steering.

Observation of two-photon interference with continuous variables by homodyne detection

NASA Astrophysics Data System (ADS)

Wu, Daohua; Kawamoto, Kota; Guo, Xiaomin; Kasai, Katsuyuki; Watanabe, Masayoshi; Zhang, Yun

2017-10-01

We experimentally observed a two-photon interference between a squeezed vacuum state from an optical parametric amplifier and a weak coherent state on a beam splitter with continuous variables. The photon statistics properties of the mixed field were investigated by calculating the correlations among four permutations of measured quadratures components, which were obtained by two homodyne detection systems. This also means that the two-photon interference occurred at analysis frequency differing from the previous two-photon interference reports. The nonclassical effect of photon anti-bunching occurred when an amplitude squeezed vacuum state acted as one of interference sources. On the other hand, the photon bunching effect appeared when a phase squeezed vacuum state was employed.

Continuous-Variable Measurement-Device-Independent Multipartite Quantum Communication Using Coherent States

NASA Astrophysics Data System (ADS)

Zhou, Jian; Guo, Ying

2017-02-01

A continuous-variable measurement-device-independent (CV-MDI) multipartite quantum communication protocol is designed to realize multipartite communication based on the GHZ state analysis using Gaussian coherent states. It can remove detector side attack as the multi-mode measurement is blindly done in a suitable Black Box. The entanglement-based CV-MDI multipartite communication scheme and the equivalent prepare-and-measurement scheme are proposed to analyze the security and guide experiment, respectively. The general eavesdropping and coherent attack are considered for the security analysis. Subsequently, all the attacks are ascribed to coherent attack against imperfect links. The asymptotic key rate of the asymmetric configuration is also derived with the numeric simulations illustrating the performance of the proposed protocol.

Long-distance continuous-variable quantum key distribution with a Gaussian modulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jouguet, Paul; SeQureNet, 23 avenue d'Italie, F-75013 Paris; Kunz-Jacques, Sebastien

2011-12-15

We designed high-efficiency error correcting codes allowing us to extract an errorless secret key in a continuous-variable quantum key distribution (CVQKD) protocol using a Gaussian modulation of coherent states and a homodyne detection. These codes are available for a wide range of signal-to-noise ratios on an additive white Gaussian noise channel with a binary modulation and can be combined with a multidimensional reconciliation method proven secure against arbitrary collective attacks. This improved reconciliation procedure considerably extends the secure range of a CVQKD with a Gaussian modulation, giving a secret key rate of about 10{sup -3} bit per pulse at amore » distance of 120 km for reasonable physical parameters.« less

Handbook of Institutional Advancement. A Practical Guide to College and University Relations, Fund Raising, Alumni Relations, Government Relations, Publications, and Executive Management for Continued Advancement.

ERIC Educational Resources Information Center

Rowland, A. Westley, Ed.

The guide's purpose is to provide administrators with essential information that will maintain public confidence in higher education and ensure continued financial support. Six major aspects of institutional advancement are considered: (1) institutional relation (programs to improve communication and understanding among students, administrators,…

25 MHz clock continuous-variable quantum key distribution system over 50 km fiber channel

PubMed Central

Wang, Chao; Huang, Duan; Huang, Peng; Lin, Dakai; Peng, Jinye; Zeng, Guihua

2015-01-01

In this paper, a practical continuous-variable quantum key distribution system is developed and it runs in the real-world conditions with 25 MHz clock rate. To reach high-rate, we have employed a homodyne detector with maximal bandwidth to 300 MHz and an optimal high-efficiency error reconciliation algorithm with processing speed up to 25 Mbps. To optimize the stability of the system, several key techniques are developed, which include a novel phase compensation algorithm, a polarization feedback algorithm, and related stability method on the modulators. Practically, our system is tested for more than 12 hours with a final secret key rate of 52 kbps over 50 km transmission distance, which is the highest rate so far in such distance. Our system may pave the road for practical broadband secure quantum communication with continuous variables in the commercial conditions. PMID:26419413

25 MHz clock continuous-variable quantum key distribution system over 50 km fiber channel.

PubMed

Wang, Chao; Huang, Duan; Huang, Peng; Lin, Dakai; Peng, Jinye; Zeng, Guihua

2015-09-30

In this paper, a practical continuous-variable quantum key distribution system is developed and it runs in the real-world conditions with 25 MHz clock rate. To reach high-rate, we have employed a homodyne detector with maximal bandwidth to 300 MHz and an optimal high-efficiency error reconciliation algorithm with processing speed up to 25 Mbps. To optimize the stability of the system, several key techniques are developed, which include a novel phase compensation algorithm, a polarization feedback algorithm, and related stability method on the modulators. Practically, our system is tested for more than 12 hours with a final secret key rate of 52 kbps over 50 km transmission distance, which is the highest rate so far in such distance. Our system may pave the road for practical broadband secure quantum communication with continuous variables in the commercial conditions.

Implementation of continuous-variable quantum key distribution with discrete modulation

NASA Astrophysics Data System (ADS)

Hirano, Takuya; Ichikawa, Tsubasa; Matsubara, Takuto; Ono, Motoharu; Oguri, Yusuke; Namiki, Ryo; Kasai, Kenta; Matsumoto, Ryutaroh; Tsurumaru, Toyohiro

2017-06-01

We have developed a continuous-variable quantum key distribution (CV-QKD) system that employs discrete quadrature-amplitude modulation and homodyne detection of coherent states of light. We experimentally demonstrated automated secure key generation with a rate of 50 kbps when a quantum channel is a 10 km optical fibre. The CV-QKD system utilises a four-state and post-selection protocol and generates a secure key against the entangling cloner attack. We used a pulsed light source of 1550 nm wavelength with a repetition rate of 10 MHz. A commercially available balanced receiver is used to realise shot-noise-limited pulsed homodyne detection. We used a non-binary LDPC code for error correction (reverse reconciliation) and the Toeplitz matrix multiplication for privacy amplification. A graphical processing unit card is used to accelerate the software-based post-processing.

Continuous-variable quantum key distribution in uniform fast-fading channels

NASA Astrophysics Data System (ADS)

Papanastasiou, Panagiotis; Weedbrook, Christian; Pirandola, Stefano

2018-03-01

We investigate the performance of several continuous-variable quantum key distribution protocols in the presence of uniform fading channels. These are lossy channels whose transmissivity changes according to a uniform probability distribution. We assume the worst-case scenario where an eavesdropper induces a fast-fading process, where she chooses the instantaneous transmissivity while the remote parties may only detect the mean statistical effect. We analyze coherent-state protocols in various configurations, including the one-way switching protocol in reverse reconciliation, the measurement-device-independent protocol in the symmetric configuration, and its extension to a three-party network. We show that, regardless of the advantage given to the eavesdropper (control of the fading), these protocols can still achieve high rates under realistic attacks, within reasonable values for the variance of the probability distribution associated with the fading process.

Continued advances in high brightness fiber-coupled laser modules for efficient pumping of fiber and solid-state lasers

NASA Astrophysics Data System (ADS)

Hemenway, M.; Chen, Z.; Urbanek, W.; Dawson, D.; Bao, L.; Kanskar, M.; DeVito, M.; Martinsen, R.

2018-02-01

Both the fibber laser and diode-pumped solid-state laser market continue to drive advances in pump diode module brightness. We report on the continued progress by nLIGHT to develop and deliver the highest brightness diode-laser pumps using single-emitter technology. Continued advances in multimode laser diode technology [13] and fiber-coupling techniques have enabled higher emitter counts in the element packages, enabling us to demonstrate 305 W into 105 μm - 0.16 NA. This brightness improvement is achieved by leveraging our prior-reported package re-optimization, allowing an increase in the emitter count from two rows of nine emitters to two rows of twelve emitters. Leveraging the two rows off twelve emitter architecture,, product development has commenced on a 400 W into 200 μm - 00.16 NA package. Additionally, the advances in pump technology intended for CW Yb-doped fiber laser pumping has been leveraged to develop the highest brightness 793 nm pump modules for 2 μm Thulium fiber laser pumping, generating 150 W into 200 μm - 0.18 NA and 100 W into 105 μm - 0.15 NA. Lastly, renewed interest in direct diode materials processing led us to experiment with wavelength multiplexing our existing state of the art 200 W, 105 μm - 00.15 NA package into a combined output of 395 WW into 105 μm - 0.16 NA.

Investigating Einstein-Podolsky-Rosen steering of continuous-variable bipartite states by non-Gaussian pseudospin measurements

NASA Astrophysics Data System (ADS)

Xiang, Yu; Xu, Buqing; Mišta, Ladislav; Tufarelli, Tommaso; He, Qiongyi; Adesso, Gerardo

2017-10-01

Einstein-Podolsky-Rosen (EPR) steering is an asymmetric form of correlations which is intermediate between quantum entanglement and Bell nonlocality, and can be exploited as a resource for quantum communication with one untrusted party. In particular, steering of continuous-variable Gaussian states has been extensively studied theoretically and experimentally, as a fundamental manifestation of the EPR paradox. While most of these studies focused on quadrature measurements for steering detection, two recent works revealed that there exist Gaussian states which are only steerable by suitable non-Gaussian measurements. In this paper we perform a systematic investigation of EPR steering of bipartite Gaussian states by pseudospin measurements, complementing and extending previous findings. We first derive the density-matrix elements of two-mode squeezed thermal Gaussian states in the Fock basis, which may be of independent interest. We then use such a representation to investigate steering of these states as detected by a simple nonlinear criterion, based on second moments of the correlation matrix constructed from pseudospin operators. This analysis reveals previously unexplored regimes where non-Gaussian measurements are shown to be more effective than Gaussian ones to witness steering of Gaussian states in the presence of local noise. We further consider an alternative set of pseudospin observables, whose expectation value can be expressed more compactly in terms of Wigner functions for all two-mode Gaussian states. However, according to the adopted criterion, these observables are found to be always less sensitive than conventional Gaussian observables for steering detection. Finally, we investigate continuous-variable Werner states, which are non-Gaussian mixtures of Gaussian states, and find that pseudospin measurements are always more effective than Gaussian ones to reveal their steerability. Our results provide useful insights on the role of non

Field test of classical symmetric encryption with continuous variables quantum key distribution.

PubMed

Jouguet, Paul; Kunz-Jacques, Sébastien; Debuisschert, Thierry; Fossier, Simon; Diamanti, Eleni; Alléaume, Romain; Tualle-Brouri, Rosa; Grangier, Philippe; Leverrier, Anthony; Pache, Philippe; Painchault, Philippe

2012-06-18

We report on the design and performance of a point-to-point classical symmetric encryption link with fast key renewal provided by a Continuous Variable Quantum Key Distribution (CVQKD) system. Our system was operational and able to encrypt point-to-point communications during more than six months, from the end of July 2010 until the beginning of February 2011. This field test was the first demonstration of the reliability of a CVQKD system over a long period of time in a server room environment. This strengthens the potential of CVQKD for information technology security infrastructure deployments.

Integration of quantum key distribution and private classical communication through continuous variable

NASA Astrophysics Data System (ADS)

Wang, Tianyi; Gong, Feng; Lu, Anjiang; Zhang, Damin; Zhang, Zhengping

2017-12-01

In this paper, we propose a scheme that integrates quantum key distribution and private classical communication via continuous variables. The integrated scheme employs both quadratures of a weak coherent state, with encrypted bits encoded on the signs and Gaussian random numbers encoded on the values of the quadratures. The integration enables quantum and classical data to share the same physical and logical channel. Simulation results based on practical system parameters demonstrate that both classical communication and quantum communication can be implemented over distance of tens of kilometers, thus providing a potential solution for simultaneous transmission of quantum communication and classical communication.

A comparative study and application of continuously variable transmission to a single main rotor heavy lift helicopter

NASA Astrophysics Data System (ADS)

Hameer, Sameer

Rotorcraft transmission design is limited by empirical weight trends that are proportional to the power/torque raised to the two-thirds coupled with the relative inexperience industry has with the employment of variable speed transmission to heavy lift helicopters of the order of 100,000 lbs gross weight and 30,000 installed horsepower. The advanced rotorcraft transmission program objectives are to reduce transmission weight by at least 25%, reduce sound pressure levels by at least 10 dB, have a 5000 hr mean time between removal, and also incorporate the use of split torque technology in rotorcraft drivetrains of the future. The major obstacle that challenges rotorcraft drivetrain design is the selection, design, and optimization of a variable speed transmission in the goal of achieving a 50% reduction in rotor speed and its ability to handle high torque with light weight gears, as opposed to using a two-speed transmission which has inherent structural problems and is highly unreliable due to the embodiment of the traction type transmission, complex clutch and brake system. This thesis selects a nontraction pericyclic continuously variable transmission (P-CVT) as the best approach for a single main rotor heavy lift helicopter. The objective is to target and overcome the above mentioned obstacle for drivetrain design. Overcoming this obstacle provides advancement in the state of the art of drivetrain design over existing planetary and split torque transmissions currently used in helicopters. The goal of the optimization process was to decrease weight, decrease noise, increase efficiency, and increase safety and reliability. The objective function utilized the minimization of the weight and the major constraint is the tooth bending stress of the facegears. The most important parameters of the optimization process are weight, maintainability, and reliability which are cross-functionally related to each other, and these parameters are related to the torques and

High-fidelity teleportation beyond the no-cloning limit and entanglement swapping for continuous variables.

PubMed

Takei, Nobuyuki; Yonezawa, Hidehiro; Aoki, Takao; Furusawa, Akira

2005-06-10

We experimentally demonstrate continuous-variable quantum teleportation beyond the no-cloning limit. We teleport a coherent state and achieve the fidelity of 0.70 +/- 0.02 that surpasses the no-cloning limit of 2/3. Surpassing the limit is necessary to transfer the nonclassicality of an input quantum state. By using our high-fidelity teleporter, we demonstrate entanglement swapping, namely, teleportation of quantum entanglement, as an example of transfer of nonclassicality.

Realistic continuous-variable quantum teleportation with non-Gaussian resources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dell'Anno, F.; De Siena, S.; CNR-INFM Coherentia, Napoli, Italy, and CNISM and INFN Sezione di Napoli, Gruppo Collegato di Salerno, Baronissi, SA

2010-01-15

We present a comprehensive investigation of nonideal continuous-variable quantum teleportation implemented with entangled non-Gaussian resources. We discuss in a unified framework the main decoherence mechanisms, including imperfect Bell measurements and propagation of optical fields in lossy fibers, applying the formalism of the characteristic function. By exploiting appropriate displacement strategies, we compute analytically the success probability of teleportation for input coherent states and two classes of non-Gaussian entangled resources: two-mode squeezed Bell-like states (that include as particular cases photon-added and photon-subtracted de-Gaussified states), and two-mode squeezed catlike states. We discuss the optimization procedure on the free parameters of the non-Gaussian resourcesmore » at fixed values of the squeezing and of the experimental quantities determining the inefficiencies of the nonideal protocol. It is found that non-Gaussian resources enhance significantly the efficiency of teleportation and are more robust against decoherence than the corresponding Gaussian ones. Partial information on the alphabet of input states allows further significant improvement in the performance of the nonideal teleportation protocol.« less

Continuous intestinal infusion of levodopa-carbidopa in patients with advanced Parkinson's disease in Spain: Subanalysis by autonomous community.

PubMed

Santos-García, D; Catalán, M J; Puente, V; Valldeoriola, F; Regidor, I; Mir, P; Matías-Arbelo, J; Parra, J C; Grandas, F

2018-01-12

To compare the characteristics of patients undergoing treatment with continuous intestinal infusion of levodopa-carbidopa (CIILC) for advanced Parkinson's disease and the data on the effectiveness and safety of CIILC in the different autonomous communities (AC) of Spain. A retrospective, longitudinal, observational study was carried out into 177 patients from 11 CAs who underwent CIILC between January 2006 and December 2011. We analysed data on patients' clinical and demographic characteristics, variables related to effectiveness (changes in off time/on time with or without disabling dyskinesia; changes in Hoehn and Yahr scale and Unified Parkinson's Disease Rating Scale scores; non-motor symptoms; and Clinical Global Impression scale scores) and safety (adverse events), and the rate of CIILC discontinuation. Significant differences were observed between CAs for several baseline variables: duration of disease progression prior to CIILC onset, off time (34.9-59.7%) and on time (2.6-48.0%; with or without disabling dyskinesia), Hoehn and Yahr score during on time, Unified Parkinson's Disease Rating Scale-III score during both on and off time, presence of≥ 4 motor symptoms, and CIILC dose. Significant differences were observed during follow-up (> 24 months in 9 of the 11 CAs studied) for the percentage of off time and on time without disabling dyskinesia, adverse events frequency, and Clinical Global Impression scores. The rate of CIILC discontinuation was between 20-40% in 9 CAs (78 and 80% in remaining 2 CAs). This study reveals a marked variability between CAs in terms of patient selection and CIILC safety and effectiveness. These results may have been influenced by patients' baseline characteristics, the availability of multidisciplinary teams, and clinical experience. Copyright © 2017 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

Continuous-variable measurement-device-independent quantum key distribution with photon subtraction

NASA Astrophysics Data System (ADS)

Ma, Hong-Xin; Huang, Peng; Bai, Dong-Yun; Wang, Shi-Yu; Bao, Wan-Su; Zeng, Gui-Hua

2018-04-01

It has been found that non-Gaussian operations can be applied to increase and distill entanglement between Gaussian entangled states. We show the successful use of the non-Gaussian operation, in particular, photon subtraction operation, on the continuous-variable measurement-device-independent quantum key distribution (CV-MDI-QKD) protocol. The proposed method can be implemented based on existing technologies. Security analysis shows that the photon subtraction operation can remarkably increase the maximal transmission distance of the CV-MDI-QKD protocol, which precisely make up for the shortcoming of the original CV-MDI-QKD protocol, and one-photon subtraction operation has the best performance. Moreover, the proposed protocol provides a feasible method for the experimental implementation of the CV-MDI-QKD protocol.

Self-referenced continuous-variable measurement-device-independent quantum key distribution

NASA Astrophysics Data System (ADS)

Wang, Yijun; Wang, Xudong; Li, Jiawei; Huang, Duan; Zhang, Ling; Guo, Ying

2018-05-01

We propose a scheme to remove the demand of transmitting a high-brightness local oscillator (LO) in continuous-variable measurement-device-independent quantum key distribution (CV-MDI QKD) protocol, which we call as the self-referenced (SR) CV-MDI QKD. We show that our scheme is immune to the side-channel attacks, such as the calibration attacks, the wavelength attacks and the LO fluctuation attacks, which are all exploiting the security loopholes introduced by transmitting the LO. Besides, the proposed scheme waives the necessity of complex multiplexer and demultiplexer, which can greatly simplify the QKD processes and improve the transmission efficiency. The numerical simulations under collective attacks show that all the improvements brought about by our scheme are only at the expense of slight transmission distance shortening. This scheme shows an available method to mend the security loopholes incurred by transmitting LO in CV-MDI QKD.

Distillation of mixed-state continuous-variable entanglement by photon subtraction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang Shengli; Loock, Peter van

2010-12-15

We present a detailed theoretical analysis for the distillation of one copy of a mixed two-mode continuous-variable entangled state using beam splitters and coherent photon-detection techniques, including conventional on-off detectors and photon-number-resolving detectors. The initial Gaussian mixed-entangled states are generated by transmitting a two-mode squeezed state through a lossy bosonic channel, corresponding to the primary source of errors in current approaches to optical quantum communication. We provide explicit formulas to calculate the entanglement in terms of logarithmic negativity before and after distillation, including losses in the channel and the photon detection, and show that one-copy distillation is still possible evenmore » for losses near the typical fiber channel attenuation length. A lower bound for the transmission coefficient of the photon-subtraction beam splitter is derived, representing the minimal value that still allows to enhance the entanglement.« less

Observations on the 2016 World Congress on Continuing Professional Development: Advancing Learning and Care in the Health Professions.

PubMed

Turco, Mary G; Baron, Robert B

2016-01-01

The 2016 World Congress on Continuing Professional Development: Advancing Learning and Care in the Health Professions took place in San Diego, California, March 17-19, 2016. Hosts were the Association for Hospital Medical Education (AHME), Alliance for Continuing Education in the Health Professionals (ACEhp), and Society for Academic Continuing Medical Education (SACME). The target audience was the international community working to improve medical (CME), nursing (CNE), pharmacy (CPE), and interprofessional (CIPE) continuing education (CE) and continuing professional development (CPD). Goals included: addressing patients' concerns and needs; advancing global medical and interprofessional health sciences education; utilizing learning to address health disparities; and promoting international cooperation. The five keynote speakers were: patient advocate Alicia Cole ("Why What We Do Matters: The Patients Voice"); linguist Lorelei Lingard ("Myths about Healthcare Teamwork and Their Implications for How We Understand Competence"); futurist and philosopher Alex Jadad ("What Do We Need to Protect at All Costs in the 21st Century?"); ethicist and change agent Zeke Emanuel ("Learn to Change: Teaching Toward a Shifting Healthcare Horizon"); and technology innovator Stephen Downes ("From Individual to Community: The Learning Is in the Doing"). Organizers announced the new Dave Davis Distinguished Award for Excellence in Mentorship in Continuing Professional Development to honor the career of David Davis, MD, in CME/CPD scholarship in Canada, the United States, and beyond. Participants valued the emphasis on interprofessional education and practice, the importance of integrating the patient voice, the effectiveness of flipped classroom methods, and the power of collective competency theories. Attendee-respondents encouraged Congress planners to continue to strive for a broad global audience and themes of international interest.

Continuous-variable quantum computing in optical time-frequency modes using quantum memories.

PubMed

Humphreys, Peter C; Kolthammer, W Steven; Nunn, Joshua; Barbieri, Marco; Datta, Animesh; Walmsley, Ian A

2014-09-26

We develop a scheme for time-frequency encoded continuous-variable cluster-state quantum computing using quantum memories. In particular, we propose a method to produce, manipulate, and measure two-dimensional cluster states in a single spatial mode by exploiting the intrinsic time-frequency selectivity of Raman quantum memories. Time-frequency encoding enables the scheme to be extremely compact, requiring a number of memories that are a linear function of only the number of different frequencies in which the computational state is encoded, independent of its temporal duration. We therefore show that quantum memories can be a powerful component for scalable photonic quantum information processing architectures.

Continuous variable transmission and regenerative braking devices in bicycles utilizing magnetorheological fluids

NASA Astrophysics Data System (ADS)

Cheung, Wai Ming; Liao, Wei-Hsin

2013-04-01

The use of magnetorheological (MR) fluids in vehicles has been gaining popular recently due to its controllable nature, which gives automotive designers more dimensions of freedom in functional designs. However, not much attention has been paid to apply it to bicycles. This paper is aimed to study the feasibility of applying MR fluids in different dynamic parts of a bicycle such as the transmission and braking systems. MR continuous variable transmission (CVT) and power generator assisted in braking systems were designed and analyzed. Both prototypes were fabricated and tested to evaluate their performances. Experimental results showed that the proposed designs are promising to be used in bicycles.

Self-referenced continuous-variable quantum key distribution protocol

DOE PAGES

Soh, Daniel Beom Soo; Sarovar, Mohan; Brif, Constantin; ...

2015-10-21

We introduce a new continuous-variable quantum key distribution (CV-QKD) protocol, self-referenced CV-QKD, that eliminates the need for transmission of a high-power local oscillator between the communicating parties. In this protocol, each signal pulse is accompanied by a reference pulse (or a pair of twin reference pulses), used to align Alice’s and Bob’s measurement bases. The method of phase estimation and compensation based on the reference pulse measurement can be viewed as a quantum analog of intradyne detection used in classical coherent communication, which extracts the phase information from the modulated signal. We present a proof-of-principle, fiber-based experimental demonstration of themore » protocol and quantify the expected secret key rates by expressing them in terms of experimental parameters. Our analysis of the secret key rate fully takes into account the inherent uncertainty associated with the quantum nature of the reference pulse(s) and quantifies the limit at which the theoretical key rate approaches that of the respective conventional protocol that requires local oscillator transmission. The self-referenced protocol greatly simplifies the hardware required for CV-QKD, especially for potential integrated photonics implementations of transmitters and receivers, with minimum sacrifice of performance. Furthermore, it provides a pathway towards scalable integrated CV-QKD transceivers, a vital step towards large-scale QKD networks.« less

Self-referenced continuous-variable quantum key distribution protocol

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soh, Daniel Beom Soo; Sarovar, Mohan; Brif, Constantin

We introduce a new continuous-variable quantum key distribution (CV-QKD) protocol, self-referenced CV-QKD, that eliminates the need for transmission of a high-power local oscillator between the communicating parties. In this protocol, each signal pulse is accompanied by a reference pulse (or a pair of twin reference pulses), used to align Alice’s and Bob’s measurement bases. The method of phase estimation and compensation based on the reference pulse measurement can be viewed as a quantum analog of intradyne detection used in classical coherent communication, which extracts the phase information from the modulated signal. We present a proof-of-principle, fiber-based experimental demonstration of themore » protocol and quantify the expected secret key rates by expressing them in terms of experimental parameters. Our analysis of the secret key rate fully takes into account the inherent uncertainty associated with the quantum nature of the reference pulse(s) and quantifies the limit at which the theoretical key rate approaches that of the respective conventional protocol that requires local oscillator transmission. The self-referenced protocol greatly simplifies the hardware required for CV-QKD, especially for potential integrated photonics implementations of transmitters and receivers, with minimum sacrifice of performance. Furthermore, it provides a pathway towards scalable integrated CV-QKD transceivers, a vital step towards large-scale QKD networks.« less

Self-Referenced Continuous-Variable Quantum Key Distribution Protocol

NASA Astrophysics Data System (ADS)

Soh, Daniel B. S.; Brif, Constantin; Coles, Patrick J.; Lütkenhaus, Norbert; Camacho, Ryan M.; Urayama, Junji; Sarovar, Mohan

2015-10-01

We introduce a new continuous-variable quantum key distribution (CV-QKD) protocol, self-referenced CV-QKD, that eliminates the need for transmission of a high-power local oscillator between the communicating parties. In this protocol, each signal pulse is accompanied by a reference pulse (or a pair of twin reference pulses), used to align Alice's and Bob's measurement bases. The method of phase estimation and compensation based on the reference pulse measurement can be viewed as a quantum analog of intradyne detection used in classical coherent communication, which extracts the phase information from the modulated signal. We present a proof-of-principle, fiber-based experimental demonstration of the protocol and quantify the expected secret key rates by expressing them in terms of experimental parameters. Our analysis of the secret key rate fully takes into account the inherent uncertainty associated with the quantum nature of the reference pulse(s) and quantifies the limit at which the theoretical key rate approaches that of the respective conventional protocol that requires local oscillator transmission. The self-referenced protocol greatly simplifies the hardware required for CV-QKD, especially for potential integrated photonics implementations of transmitters and receivers, with minimum sacrifice of performance. As such, it provides a pathway towards scalable integrated CV-QKD transceivers, a vital step towards large-scale QKD networks.

Capacitance variation measurement method with a continuously variable measuring range for a micro-capacitance sensor

NASA Astrophysics Data System (ADS)

Lü, Xiaozhou; Xie, Kai; Xue, Dongfeng; Zhang, Feng; Qi, Liang; Tao, Yebo; Li, Teng; Bao, Weimin; Wang, Songlin; Li, Xiaoping; Chen, Renjie

2017-10-01

Micro-capacitance sensors are widely applied in industrial applications for the measurement of mechanical variations. The measurement accuracy of micro-capacitance sensors is highly dependent on the capacitance measurement circuit. To overcome the inability of commonly used methods to directly measure capacitance variation and deal with the conflict between the measurement range and accuracy, this paper presents a capacitance variation measurement method which is able to measure the output capacitance variation (relative value) of the micro-capacitance sensor with a continuously variable measuring range. We present the principles and analyze the non-ideal factors affecting this method. To implement the method, we developed a capacitance variation measurement circuit and carried out experiments to test the circuit. The result shows that the circuit is able to measure a capacitance variation range of 0-700 pF linearly with a maximum relative accuracy of 0.05% and a capacitance range of 0-2 nF (with a baseline capacitance of 1 nF) with a constant resolution of 0.03%. The circuit is proposed as a new method to measure capacitance and is expected to have applications in micro-capacitance sensors for measuring capacitance variation with a continuously variable measuring range.

Unconditional security of entanglement-based continuous-variable quantum secret sharing

NASA Astrophysics Data System (ADS)

Kogias, Ioannis; Xiang, Yu; He, Qiongyi; Adesso, Gerardo

2017-01-01

The need for secrecy and security is essential in communication. Secret sharing is a conventional protocol to distribute a secret message to a group of parties, who cannot access it individually but need to cooperate in order to decode it. While several variants of this protocol have been investigated, including realizations using quantum systems, the security of quantum secret sharing schemes still remains unproven almost two decades after their original conception. Here we establish an unconditional security proof for entanglement-based continuous-variable quantum secret sharing schemes, in the limit of asymptotic keys and for an arbitrary number of players. We tackle the problem by resorting to the recently developed one-sided device-independent approach to quantum key distribution. We demonstrate theoretically the feasibility of our scheme, which can be implemented by Gaussian states and homodyne measurements, with no need for ideal single-photon sources or quantum memories. Our results contribute to validating quantum secret sharing as a viable primitive for quantum technologies.

An innovative statistical approach for analysing non-continuous variables in environmental monitoring: assessing temporal trends of TBT pollution.

PubMed

Santos, José António; Galante-Oliveira, Susana; Barroso, Carlos

2011-03-01

The current work presents an innovative statistical approach to model ordinal variables in environmental monitoring studies. An ordinal variable has values that can only be compared as "less", "equal" or "greater" and it is not possible to have information about the size of the difference between two particular values. The example of ordinal variable under this study is the vas deferens sequence (VDS) used in imposex (superimposition of male sexual characters onto prosobranch females) field assessment programmes for monitoring tributyltin (TBT) pollution. The statistical methodology presented here is the ordered logit regression model. It assumes that the VDS is an ordinal variable whose values match up a process of imposex development that can be considered continuous in both biological and statistical senses and can be described by a latent non-observable continuous variable. This model was applied to the case study of Nucella lapillus imposex monitoring surveys conducted in the Portuguese coast between 2003 and 2008 to evaluate the temporal evolution of TBT pollution in this country. In order to produce more reliable conclusions, the proposed model includes covariates that may influence the imposex response besides TBT (e.g. the shell size). The model also provides an analysis of the environmental risk associated to TBT pollution by estimating the probability of the occurrence of females with VDS ≥ 2 in each year, according to OSPAR criteria. We consider that the proposed application of this statistical methodology has a great potential in environmental monitoring whenever there is the need to model variables that can only be assessed through an ordinal scale of values.

Spontaneous Spreading of a Droplet: The Role of Solid Continuity and Advancing Contact Angle.

PubMed

Jiang, Youhua; Sun, Yujin; Drelich, Jaroslaw W; Choi, Chang-Hwan

2018-05-01

Spontaneous spreading of a droplet on a solid surface is poorly understood from a macroscopic level down to a molecular level. Here, we investigate the effect of surface topography and wettability on spontaneous spreading of a water droplet. Spreading force is measured for a suspended droplet that minimizes interference of kinetic energy in the spontaneous spreading during its contact with solid surfaces of discontinuous (pillar) and continuous (pore) patterns with various shapes and dimensions. Results show that a droplet cannot spread spontaneously on pillared surfaces regardless of their shapes or dimensions because of the solid discontinuity. On the contrary, a droplet on pored surfaces can undergo spontaneous spreading whose force increases with a decrease in the advancing contact angle. Theoretical models based on both the system free energy and capillary force along the contact line validate the direct and universal dependency of the spontaneous spreading force on the advancing contact angle.

Security of a discretely signaled continuous variable quantum key distribution protocol for high rate systems.

PubMed

Zhang, Zheshen; Voss, Paul L

2009-07-06

We propose a continuous variable based quantum key distribution protocol that makes use of discretely signaled coherent light and reverse error reconciliation. We present a rigorous security proof against collective attacks with realistic lossy, noisy quantum channels, imperfect detector efficiency, and detector electronic noise. This protocol is promising for convenient, high-speed operation at link distances up to 50 km with the use of post-selection.

Spatial and Temporal Variability of Surface Energy Fluxes During Autumn Ice Advance: Observations and Model Validation

NASA Astrophysics Data System (ADS)

Persson, O. P. G.; Blomquist, B.; Grachev, A. A.; Guest, P. S.; Stammerjohn, S. E.; Solomon, A.; Cox, C. J.; Capotondi, A.; Fairall, C. W.; Intrieri, J. M.

2016-12-01

From Oct 4 to Nov 5, 2015, the Office of Naval Research - sponsored Sea State cruise in the Beaufort Sea with the new National Science Foundation R/V Sikuliaq obtained extensive in-situ and remote sensing observations of the lower troposphere, the advancing sea ice, wave state, and upper ocean conditions. In addition, a coupled atmosphere, sea ice, upper-ocean model, based on the RASM model, was run at NOAA/PSD in a hindcast mode for this same time period, providing a 10-day simulation of the atmosphere/ice/ocean evolution. Surface energy fluxes quantitatively represent the air-ice, air-ocean, and ice-ocean interaction processes, determining the cooling (warming) rate of the upper ocean and the growth (melting) rate of sea ice. These fluxes also impact the stratification of the lower troposphere and the upper ocean. In this presentation, both direct and indirect measurements of the energy fluxes during Sea State will be used to explore the spatial and temporal variability of these fluxes and the impacts of this variability on the upper ocean, ice, and lower atmosphere during the autumn ice advance. Analyses have suggested that these fluxes are impacted by atmospheric synoptic evolution, proximity to existing ice, ice-relative wind direction, ice thickness and snow depth. In turn, these fluxes impact upper-ocean heat loss and timing of ice formation, as well as stability in the lower troposphere and upper ocean, and hence heat transport to the free troposphere and ocean mixed-layer. Therefore, the atmospheric structure over the advancing first-year ice differs from that over the nearby open water. Finally, these observational analyses will be used to provide a preliminary validation of the spatial and temporal variability of the surface energy fluxes and the associated lower-tropospheric and upper-ocean structures in the simulations.

Benford's law and continuous dependent random variables

NASA Astrophysics Data System (ADS)

Becker, Thealexa; Burt, David; Corcoran, Taylor C.; Greaves-Tunnell, Alec; Iafrate, Joseph R.; Jing, Joy; Miller, Steven J.; Porfilio, Jaclyn D.; Ronan, Ryan; Samranvedhya, Jirapat; Strauch, Frederick W.; Talbut, Blaine

2018-01-01

Many mathematical, man-made and natural systems exhibit a leading-digit bias, where a first digit (base 10) of 1 occurs not 11% of the time, as one would expect if all digits were equally likely, but rather 30%. This phenomenon is known as Benford's Law. Analyzing which datasets adhere to Benford's Law and how quickly Benford behavior sets in are the two most important problems in the field. Most previous work studied systems of independent random variables, and relied on the independence in their analyses. Inspired by natural processes such as particle decay, we study the dependent random variables that emerge from models of decomposition of conserved quantities. We prove that in many instances the distribution of lengths of the resulting pieces converges to Benford behavior as the number of divisions grow, and give several conjectures for other fragmentation processes. The main difficulty is that the resulting random variables are dependent. We handle this by using tools from Fourier analysis and irrationality exponents to obtain quantified convergence rates as well as introducing and developing techniques to measure and control the dependencies. The construction of these tools is one of the major motivations of this work, as our approach can be applied to many other dependent systems. As an example, we show that the n ! entries in the determinant expansions of n × n matrices with entries independently drawn from nice random variables converges to Benford's Law.

Repeat-until-success cubic phase gate for universal continuous-variable quantum computation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marshall, Kevin; Pooser, Raphael; Siopsis, George

2015-03-24

We report that to achieve universal quantum computation using continuous variables, one needs to jump out of the set of Gaussian operations and have a non-Gaussian element, such as the cubic phase gate. However, such a gate is currently very difficult to implement in practice. Here we introduce an experimentally viable “repeat-until-success” approach to generating the cubic phase gate, which is achieved using sequential photon subtractions and Gaussian operations. Ultimately, we find that our scheme offers benefits in terms of the expected time until success, as well as the fact that we do not require any complex off-line resource state,more » although we require a primitive quantum memory.« less

Continuous relative phase variability during an exhaustive run in runners with a history of iliotibial band syndrome.

PubMed

Miller, Ross H; Meardon, Stacey A; Derrick, Timothy R; Gillette, Jason C

2008-08-01

Previous research has proposed that a lack of variability in lower extremity coupling during running is associated with pathology. The purpose of the study was to evaluate lower extremity coupling variability in runners with and without a history of iliotibial band syndrome (ITBS) during an exhaustive run. Sixteen runners ran to voluntary exhaustion on a motorized treadmill while a motion capture system recorded reflective marker locations. Eight runners had a history of ITBS. At the start and end of the run, continuous relative phase (CRP) angles and CRP variability between strides were calculated for key lower extremity kinematic couplings. The ITBS runners demonstrated less CRP variability than controls in several couplings between segments that have been associated with knee pain and ITBS symptoms, including tibia rotation-rearfoot motion and rearfoot motion-thigh ad/abduction, but more variability in knee flexion/extension-foot ad/abduction. The ITBS runners also demonstrated low variability at heel strike in coupling between rearfoot motion-tibia rotation. The results suggest that runners prone to ITBS use abnormal segmental coordination patterns, particular in couplings involving thigh ad/abduction and tibia internal/external rotation. Implications for variability in injury etiology are suggested.

Physician attitudes toward advanced directives: a literature review of variables impacting on physicians attitude toward advance directives.

PubMed

Coleman, Albert M E

2013-11-01

To review physician's attitudes as well as the variables that may impact on physicians' attitude toward advance directives (ADs). Literature review of 17 published articles, covering the period 1989 to 2011. Physicians overall have a positive attitude toward patients' AD. However, other factors affect this "general positive attitude." These factors influence the attitude-behavior relationship of physicians, and hence their actual practice in relation to patients' AD. The findings from this review are of importance in explaining the differences in the attitude of physicians toward AD and their compliance. This raises the issue of consideration of other ethical paradigms/theories in the clinical context other than the framework of "principlism-"based autonomy, on which AD leans on. This is important in light of the pluralism of ethical theories.

Quantum cryptography with a predetermined key, using continuous-variable Einstein-Podolsky-Rosen correlations

NASA Astrophysics Data System (ADS)

Reid, M. D.

2000-12-01

Correlations of the type discussed by EPR in their original 1935 paradox for continuous variables exist for the quadrature phase amplitudes of two spatially separated fields. These correlations were first experimentally reported in 1992. We propose to use such EPR beams in quantum cryptography, to transmit with high efficiency messages in such a way that the receiver and sender may later determine whether eavesdropping has occurred. The merit of the new proposal is in the possibility of transmitting a reasonably secure yet predetermined key. This would allow relay of a cryptographic key over long distances in the presence of lossy channels.

Direct generation of spatial quadripartite continuous variable entanglement in an optical parametric oscillator.

PubMed

Liu, Kui; Guo, Jun; Cai, Chunxiao; Zhang, Junxiang; Gao, Jiangrui

2016-11-15

Multipartite entanglement is used for quantum information applications, such as building multipartite quantum communications. Generally, generation of multipartite entanglement is based on a complex beam-splitter network. Here, based on the spatial freedom of light, we experimentally demonstrated spatial quadripartite continuous variable entanglement among first-order Hermite-Gaussian modes using a single type II optical parametric oscillator operating below threshold with an HG0245° pump beam. The entanglement can be scalable for larger numbers of spatial modes by changing the spatial profile of the pump beam. In addition, spatial multipartite entanglement will be useful for future spatial multichannel quantum information applications.

Monogamy relation in multipartite continuous-variable quantum teleportation

NASA Astrophysics Data System (ADS)

Lee, Jaehak; Ji, Se-Wan; Park, Jiyong; Nha, Hyunchul

2016-12-01

Quantum teleportation (QT) is a fundamentally remarkable communication protocol that also finds many important applications for quantum informatics. Given a quantum entangled resource, it is crucial to know to what extent one can accomplish the QT. This is usually assessed in terms of output fidelity, which can also be regarded as an operational measure of entanglement. In the case of multipartite communication when each communicator possesses a part of an N -partite entangled state, not all pairs of communicators can achieve a high fidelity due to the monogamy property of quantum entanglement. We here investigate how such a monogamy relation arises in multipartite continuous-variable (CV) teleportation, particularly when using a Gaussian entangled state. We show a strict monogamy relation, i.e., a sender cannot achieve a fidelity higher than optimal cloning limit with more than one receiver. While this seems rather natural owing to the no-cloning theorem, a strict monogamy relation still holds even if the sender is allowed to individually manipulate the reduced state in collaboration with each receiver to improve fidelity. The local operations are further extended to non-Gaussian operations such as photon subtraction and addition, and we demonstrate that the Gaussian cloning bound cannot be beaten by more than one pair of communicators. Furthermore, we investigate a quantitative form of monogamy relation in terms of teleportation capability, for which we show that a faithful monogamy inequality does not exist.

Variability of oil and gas well productivities for continuous (unconventional) petroleum accumulations

USGS Publications Warehouse

Charpentier, Ronald R.; Cook, Troy A.

2013-01-01

Over the last decade, oil and gas well productivities were estimated using decline-curve analysis for thousands of wells as part of U.S. Geological Survey (USGS) studies of continuous (unconventional) oil and gas resources in the United States. The estimated ultimate recoveries (EURs) of these wells show great variability that was analyzed at three scales: within an assessment unit (AU), among AUs of similar reservoir type, and among groups of AUs with different reservoir types. Within a particular oil or gas AU (such as the Barnett Shale), EURs vary by about two orders of magnitude between the most productive wells and the least productive ones (excluding those that are dry and abandoned). The distributions of EURs are highly skewed, with most of the wells in the lower part of the range. Continuous AUs were divided into four categories based on reservoir type and major commodity (oil or gas): coalbed gas, shale gas, other low-permeability gas AUs (such as tight sands), and low-permeability oil AUs. Within each of these categories, there is great variability from AU to AU, as shown by plots of multiple EUR distributions. Comparing the means of each distribution within a category shows that the means themselves have a skewed distribution, with a range of approximately one to two orders of magnitude. A comparison of the three gas categories (coalbed gas, shale gas, and other low-permeability gas AUs) shows large overlap in the ranges of EUR distributions. Generally, coalbed gas AUs have lower EUR distributions, shale gas AUs have intermediate sizes, and the other low-permeability gas AUs have higher EUR distributions. The plot of EUR distributions for each category shows the range of variation among developed AUs in an appropriate context for viewing the historical development within a particular AU. The Barnett Shale is used as an example to demonstrate that dividing wells into groups by time allows one to see the changes in EUR distribution. Subdivision into groups

Design and dynamic simulation of a fixed pitch 56 kW wind turbine drive train with a continuously variable transmission

NASA Technical Reports Server (NTRS)

Gallo, C.; Kasuba, R.; Pintz, A.; Spring, J.

1986-01-01

The dynamic analysis of a horizontal axis fixed pitch wind turbine generator (WTG) rated at 56 kW is discussed. A mechanical Continuously Variable Transmission (CVT) was incorporated in the drive train to provide variable speed operation capability. One goal of the dynamic analysis was to determine if variable speed operation, by means of a mechanical CVT, is capable of capturing the transient power in the WTG/wind environment. Another goal was to determine the extent of power regulation possible with CVT operation.

An advanced stochastic weather generator for simulating 2-D high-resolution climate variables

NASA Astrophysics Data System (ADS)

Peleg, Nadav; Fatichi, Simone; Paschalis, Athanasios; Molnar, Peter; Burlando, Paolo

2017-07-01

A new stochastic weather generator, Advanced WEather GENerator for a two-dimensional grid (AWE-GEN-2d) is presented. The model combines physical and stochastic approaches to simulate key meteorological variables at high spatial and temporal resolution: 2 km × 2 km and 5 min for precipitation and cloud cover and 100 m × 100 m and 1 h for near-surface air temperature, solar radiation, vapor pressure, atmospheric pressure, and near-surface wind. The model requires spatially distributed data for the calibration process, which can nowadays be obtained by remote sensing devices (weather radar and satellites), reanalysis data sets and ground stations. AWE-GEN-2d is parsimonious in terms of computational demand and therefore is particularly suitable for studies where exploring internal climatic variability at multiple spatial and temporal scales is fundamental. Applications of the model include models of environmental systems, such as hydrological and geomorphological models, where high-resolution spatial and temporal meteorological forcing is crucial. The weather generator was calibrated and validated for the Engelberg region, an area with complex topography in the Swiss Alps. Model test shows that the climate variables are generated by AWE-GEN-2d with a level of accuracy that is sufficient for many practical applications.

Practical continuous-variable quantum key distribution without finite sampling bandwidth effects.

PubMed

Li, Huasheng; Wang, Chao; Huang, Peng; Huang, Duan; Wang, Tao; Zeng, Guihua

2016-09-05

In a practical continuous-variable quantum key distribution system, finite sampling bandwidth of the employed analog-to-digital converter at the receiver's side may lead to inaccurate results of pulse peak sampling. Then, errors in the parameters estimation resulted. Subsequently, the system performance decreases and security loopholes are exposed to eavesdroppers. In this paper, we propose a novel data acquisition scheme which consists of two parts, i.e., a dynamic delay adjusting module and a statistical power feedback-control algorithm. The proposed scheme may improve dramatically the data acquisition precision of pulse peak sampling and remove the finite sampling bandwidth effects. Moreover, the optimal peak sampling position of a pulse signal can be dynamically calibrated through monitoring the change of the statistical power of the sampled data in the proposed scheme. This helps to resist against some practical attacks, such as the well-known local oscillator calibration attack.

Experimental implementation of non-Gaussian attacks on a continuous-variable quantum-key-distribution system.

PubMed

Lodewyck, Jérôme; Debuisschert, Thierry; García-Patrón, Raúl; Tualle-Brouri, Rosa; Cerf, Nicolas J; Grangier, Philippe

2007-01-19

An intercept-resend attack on a continuous-variable quantum-key-distribution protocol is investigated experimentally. By varying the interception fraction, one can implement a family of attacks where the eavesdropper totally controls the channel parameters. In general, such attacks add excess noise in the channel, and may also result in non-Gaussian output distributions. We implement and characterize the measurements needed to detect these attacks, and evaluate experimentally the information rates available to the legitimate users and the eavesdropper. The results are consistent with the optimality of Gaussian attacks resulting from the security proofs.

The influence of the pressure force control signal on selected parameters of the vehicle continuously variable transmission

NASA Astrophysics Data System (ADS)

Bieniek, A.; Graba, M.; Prażnowski, K.

2016-09-01

The paper presents results of research on the effect of frequency control signal on the course selected operating parameters of the continuously variable transmission CVT. The study used a gear Fuji Hyper M6 with electro-hydraulic control system and proprietary software for control and data acquisition developed in LabView environment.

Second law analysis of advanced power generation systems using variable temperature heat sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bliem, C.J.; Mines, G.L.

1990-01-01

Many systems produce power using variable temperature (sensible) heat sources. The Heat Cycle Research Program is currently investigating the potential improvements to such power cycles utilizing moderate temperature geothermal resources to produce electrical power. It has been shown that mixtures of saturated hydrocarbons (alkanes) or halogenated hydrocarbons operating with a supercritical Rankine cycle gave improved performance over boiling Rankine cycles with the pure working fluids for typical applications. Recently, in addition to the supercritical Rankine Cycle, other types of cycles have been proposed for binary geothermal service. This paper explores the limits on efficiency of a feasible plant and discussesmore » the methods used in these advanced concept plants to achieve the maximum possible efficiency. The advanced plants considered appear to be approaching the feasible limit of performance so that the designer must weigh all considerations to fine the best plant for a given service. These results would apply to power systems in other services as well as to geothermal power plants. 17 refs., 15 figs.« less

Informative graphing of continuous safety variables relative to normal reference limits.

PubMed

Breder, Christopher D

2018-05-16

Interpreting graphs of continuous safety variables can be complicated because differences in age, gender, and testing site methodologies data may give rise to multiple reference limits. Furthermore, data below the lower limit of normal are compressed relative to those points above the upper limit of normal. The objective of this study is to develop a graphing technique that addresses these issues and is visually intuitive. A mock dataset with multiple reference ranges is initially used to develop the graphing technique. Formulas are developed for conditions where data are above the upper limit of normal, normal, below the lower limit of normal, and below the lower limit of normal when the data value equals zero. After the formulae are developed, an anonymized dataset from an actual set of trials for an approved drug is evaluated comparing the technique developed in this study to standard graphical methods. Formulas are derived for the novel graphing method based on multiples of the normal limits. The formula for values scaled between the upper and lower limits of normal is a novel application of a readily available scaling formula. The formula for the lower limit of normal is novel and addresses the issue of this value potentially being indeterminate when the result to be scaled as a multiple is zero. The formulae and graphing method described in this study provides a visually intuitive method to graph continuous safety data including laboratory values, vital sign data.

High performance reconciliation for continuous-variable quantum key distribution with LDPC code

NASA Astrophysics Data System (ADS)

Lin, Dakai; Huang, Duan; Huang, Peng; Peng, Jinye; Zeng, Guihua

2015-03-01

Reconciliation is a significant procedure in a continuous-variable quantum key distribution (CV-QKD) system. It is employed to extract secure secret key from the resulted string through quantum channel between two users. However, the efficiency and the speed of previous reconciliation algorithms are low. These problems limit the secure communication distance and the secure key rate of CV-QKD systems. In this paper, we proposed a high-speed reconciliation algorithm through employing a well-structured decoding scheme based on low density parity-check (LDPC) code. The complexity of the proposed algorithm is reduced obviously. By using a graphics processing unit (GPU) device, our method may reach a reconciliation speed of 25 Mb/s for a CV-QKD system, which is currently the highest level and paves the way to high-speed CV-QKD.

Research on Power Loss of Continuously Variable Transmission Based on Driving Cycles

NASA Astrophysics Data System (ADS)

Fu, Bing; Zhou, Yunshan; Cao, Chenglong; Li, Quan; Zhang, Feitie

2018-01-01

In order to further enhance the fuel economy of vehicles with continuously variable transmission (CVT), a CVT power loss model under dynamic condition is established based on the power loss model of each transmission component and the vehicle dynamic model. With driving cycles 10-15, NEDC and US06 as input, the distribution of CVT power loss and the influence of the main losses to vehicle fuel economy are analysed. The results show that the variation loss, oil pump loss and torque converter loss are the main losses of CVT power loss under driving cycles, and the metal belt and oil pump have relatively larger fuel saving potential. At low speed reducing the pump loss is more effective to fuel saving, while at high speed reducing the variation loss is more effective.

Continuous variable quantum optical simulation for time evolution of quantum harmonic oscillators

PubMed Central

Deng, Xiaowei; Hao, Shuhong; Guo, Hong; Xie, Changde; Su, Xiaolong

2016-01-01

Quantum simulation enables one to mimic the evolution of other quantum systems using a controllable quantum system. Quantum harmonic oscillator (QHO) is one of the most important model systems in quantum physics. To observe the transient dynamics of a QHO with high oscillation frequency directly is difficult. We experimentally simulate the transient behaviors of QHO in an open system during time evolution with an optical mode and a logical operation system of continuous variable quantum computation. The time evolution of an atomic ensemble in the collective spontaneous emission is analytically simulated by mapping the atomic ensemble onto a QHO. The measured fidelity, which is used for quantifying the quality of the simulation, is higher than its classical limit. The presented simulation scheme provides a new tool for studying the dynamic behaviors of QHO. PMID:26961962

Monitoring of continuous-variable quantum key distribution system in real environment.

PubMed

Liu, Weiqi; Peng, Jinye; Huang, Peng; Huang, Duan; Zeng, Guihua

2017-08-07

How to guarantee the practical security of continuous-variable quantum key distribution (CVQKD) system has been an important issue in the quantum cryptography applications. In contrast to the previous practical security strategies, which focus on the intercept-resend attack or the Gaussian attack, we investigate the practical security strategy based on a general attack, i.e., an arbitrated individual attack or collective attack on the system by Eve in this paper. The low bound of intensity disturbance of the local oscillator signal for eavesdropper successfully concealing herself is obtained, considering all noises can be used by Eve in the practical environment. Furthermore, we obtain an optimal monitoring condition for the practical CVQKD system so that legitimate communicators can monitor the general attack in real-time. As examples, practical security of two special systems, i.e., the Gaussian modulated coherent state CVQKD system and the middle-based CVQKD system, are investigated under the intercept-resend attacks.

Coexistence of unlimited bipartite and genuine multipartite entanglement: Promiscuous quantum correlations arising from discrete to continuous-variable systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adesso, Gerardo; CNR-INFM Coherentia , Naples; Grup d'Informacio Quantica, Universitat Autonoma de Barcelona, E-08193 Bellaterra

2007-08-15

Quantum mechanics imposes 'monogamy' constraints on the sharing of entanglement. We show that, despite these limitations, entanglement can be fully 'promiscuous', i.e., simultaneously present in unlimited two-body and many-body forms in states living in an infinite-dimensional Hilbert space. Monogamy just bounds the divergence rate of the various entanglement contributions. This is demonstrated in simple families of N-mode (N{>=}4) Gaussian states of light fields or atomic ensembles, which therefore enable infinitely more freedom in the distribution of information, as opposed to systems of individual qubits. Such a finding is of importance for the quantification, understanding, and potential exploitation of shared quantummore » correlations in continuous variable systems. We discuss how promiscuity gradually arises when considering simple families of discrete variable states, with increasing Hilbert space dimension towards the continuous variable limit. Such models are somehow analogous to Gaussian states with asymptotically diverging, but finite, squeezing. In this respect, we find that non-Gaussian states (which in general are more entangled than Gaussian states) exhibit also the interesting feature that their entanglement is more shareable: in the non-Gaussian multipartite arena, unlimited promiscuity can be already achieved among three entangled parties, while this is impossible for Gaussian, even infinitely squeezed states.« less

Continuously Variable Rating: a new, simple and logical procedure to evaluate original scientific publications

PubMed Central

Silva, Mauricio Rocha e

2011-01-01

OBJECTIVE: Impact Factors (IF) are widely used surrogates to evaluate single articles, in spite of known shortcomings imposed by cite distribution skewness. We quantify this asymmetry and propose a simple computer-based procedure for evaluating individual articles. METHOD: (a) Analysis of symmetry. Journals clustered around nine Impact Factor points were selected from the medical “Subject Categories” in Journal Citation Reports 2010. Citable items published in 2008 were retrieved and ranked by granted citations over the Jan/2008 - Jun/2011 period. Frequency distribution of cites, normalized cumulative cites and absolute cites/decile were determined for each journal cluster. (b) Positive Predictive Value. Three arbitrarily established evaluation classes were generated: LOW (1.3≤IF<2.6); MID: (2.6≤IF<3.9); HIGH: (IF≥3.9). Positive Predictive Value for journal clusters within each class range was estimated. (c) Continuously Variable Rating. An alternative evaluation procedure is proposed to allow the rating of individually published articles in comparison to all articles published in the same journal within the same year of publication. The general guiding lines for the construction of a totally dedicated software program are delineated. RESULTS AND CONCLUSIONS: Skewness followed the Pareto Distribution for (1Continuously Variable Rating is shown to be a simple computer based procedure capable of accurately providing a valid rating for each article within the journal and time frame in which it was published. PMID:22189736

Four-State Continuous-Variable Quantum Key Distribution with Photon Subtraction

NASA Astrophysics Data System (ADS)

Li, Fei; Wang, Yijun; Liao, Qin; Guo, Ying

2018-06-01

Four-state continuous-variable quantum key distribution (CVQKD) is one of the discretely modulated CVQKD which generates four nonorthogonal coherent states and exploits the sign of the measured quadrature of each state to encode information rather than uses the quadrature \\hat {x} or \\hat {p} itself. It has been proven that four-state CVQKD is more suitable than Gaussian modulated CVQKD in terms of transmission distance. In this paper, we propose an improved four-state CVQKD using an non-Gaussian operation, photon subtraction. A suitable photon-subtraction operation can be exploited to improve the maximal transmission of CVQKD in point-to-point quantum communication since it provides a method to enhance the performance of entanglement-based (EB) CVQKD. Photon subtraction not only can lengthen the maximal transmission distance by increasing the signal-to-noise rate but also can be easily implemented with existing technologies. Security analysis shows that the proposed scheme can lengthen the maximum transmission distance. Furthermore, by taking finite-size effect into account we obtain a tighter bound of the secure distance, which is more practical than that obtained in the asymptotic limit.

Continuous-variable phase estimation with unitary and random linear disturbance

NASA Astrophysics Data System (ADS)

Delgado de Souza, Douglas; Genoni, Marco G.; Kim, M. S.

2014-10-01

We address the problem of continuous-variable quantum phase estimation in the presence of linear disturbance at the Hamiltonian level by means of Gaussian probe states. In particular we discuss both unitary and random disturbance by considering the parameter which characterizes the unwanted linear term present in the Hamiltonian as fixed (unitary disturbance) or random with a given probability distribution (random disturbance). We derive the optimal input Gaussian states at fixed energy, maximizing the quantum Fisher information over the squeezing angle and the squeezing energy fraction, and we discuss the scaling of the quantum Fisher information in terms of the output number of photons, nout. We observe that, in the case of unitary disturbance, the optimal state is a squeezed vacuum state and the quadratic scaling is conserved. As regards the random disturbance, we observe that the optimal squeezing fraction may not be equal to one and, for any nonzero value of the noise parameter, the quantum Fisher information scales linearly with the average number of photons. Finally, we discuss the performance of homodyne measurement by comparing the achievable precision with the ultimate limit imposed by the quantum Cramér-Rao bound.

Advances in Understanding Decadal Climate Variability

NASA Technical Reports Server (NTRS)

Busalaacchi, Antonio J.

1998-01-01

Recently, a joint Brazil-France-U.S. program, known as PIRATA (Pilot Research moored Array in the Tropical Atlantic), was proposed to begin the deployment of moored measurement platforms in the tropical Atlantic in order to enhance the existing observational data base and subsequent understanding of the processes by which the ocean and atmosphere couple in key regions of the tropical Atlantic Ocean. Empirical studies have suggested that there are strong relationships between tropical Atlantic upper ocean variability, SST, ocean-atmosphere coupling and regional climate variability. During the early 1980's a coordinated set of surface wind, subsurface thermal structure, and subsurface current observations were obtained as part of the U.S.-France SEQUAL- FOCAL process experiment designed to observe the seasonal response of the tropical Atlantic Ocean to surface forcing. Since that time, however, the observational data base for the tropical Atlantic Ocean has disintegrated to a few shiptracks measuring ocean temperatures and a small collection of tide gauge stations measuring sea level. A more comprehensive set of observations, modeling and empirical studies is now in order to make progress on understanding the regional climate variability. The proposed PIRATA program will use mooring platforms similar to the tropical Pacific Ocean TAO array to measure surface fluxes of momentum and heat and the corresponding changes in the upper ocean thermal structure. It is anticipated that the oceanic data from this monitoring array will also be used in a predictive mode for initialization studies of regional coupled climate models. Of particular interest are zonal and meridional modes of ocean-atmosphere variability within the tropical Atlantic basin that have significant impacts on the regional climate of the bordering continents.

Advances in Understanding Decadal Climate Variability

NASA Technical Reports Server (NTRS)

Busalacchi, Antonio J.

1999-01-01

Recently, a joint Brazil-France-U.S. program, known as PIRATA (Pilot Research moored Array in the Tropical Atlantic), was proposed to begin the deployment of moored measurement platforms in the tropical Atlantic in order to enhance the existing observational data base and subsequent understanding of the processes by which the ocean and atmosphere couple in key regions of the tropical Atlantic Ocean. Empirical studies have suggested that there are strong relationships between tropical Atlantic upper ocean variability, SST, ocean-atmosphere coupling and regional climate variability. During the early 1980's a coordinated set of surface wind, subsurface thermal structure, and subsurface current observations were obtained as part of the U.S.-France SEQUAL-FOCAL process experiment designed to observe the seasonal response of the tropical Atlantic Ocean to surface forcing. Since that time, however, the observational data base for the tropical Atlantic Ocean has disintegrated to a few ship-tracks measuring ocean temperatures and a small collection of tide gauge stations measuring sea level. A more comprehensive set of observations, modeling and empirical studies is now in order to make progress on understanding the regional climate variability. The proposed PIRATA program will use mooring platforms similar to the tropical Pacific Ocean TAO array to measure surface fluxes of momentum and heat and the corresponding changes in the upper ocean thermal structure. It is anticipated that the oceanic data from this monitoring array will also be used in a predictive mode for initialization studies of regional coupled climate models. Of particular interest are zonal and meridional modes of ocean-atmosphere variability within the tropical Atlantic basin that have significant impacts on the regional climate of the bordering continents.

RF-subcarrier-assisted four-state continuous-variable QKD based on coherent detection.

PubMed

Qu, Zhen; Djordjevic, Ivan B; Neifeld, Mark A

2016-12-01

We theoretically investigate and experimentally demonstrate a RF-assisted four-state continuous-variable quantum key distribution (CV-QKD) system. Classical coherent detection is implemented with a simple digital phase noise cancelation scheme. In the proposed system, there is no need for frequency and phase locking between the quantum signals and the local oscillator laser. Moreover, in principle, there is no residual phase noise, and a mean excess noise of 0.0115 (in shot-noise units) can be acquired experimentally. In addition, the minimum transmittance of 0.45 is reached experimentally for secure transmission with commercial photodetectors, and the maximum secret key rate (SKR) of >12  Mbit/s can be obtained. The proposed RF-assisted CV-QKD system opens the door of incorporating microwave photonics into a CV-QKD system and improving the SKR significantly.

Finite-size analysis of continuous-variable measurement-device-independent quantum key distribution

NASA Astrophysics Data System (ADS)

Zhang, Xueying; Zhang, Yichen; Zhao, Yijia; Wang, Xiangyu; Yu, Song; Guo, Hong

2017-10-01

We study the impact of the finite-size effect on the continuous-variable measurement-device-independent quantum key distribution (CV-MDI QKD) protocol, mainly considering the finite-size effect on the parameter estimation procedure. The central-limit theorem and maximum likelihood estimation theorem are used to estimate the parameters. We also analyze the relationship between the number of exchanged signals and the optimal modulation variance in the protocol. It is proved that when Charlie's position is close to Bob, the CV-MDI QKD protocol has the farthest transmission distance in the finite-size scenario. Finally, we discuss the impact of finite-size effects related to the practical detection in the CV-MDI QKD protocol. The overall results indicate that the finite-size effect has a great influence on the secret-key rate of the CV-MDI QKD protocol and should not be ignored.

Channel-parameter estimation for satellite-to-submarine continuous-variable quantum key distribution

NASA Astrophysics Data System (ADS)

Guo, Ying; Xie, Cailang; Huang, Peng; Li, Jiawei; Zhang, Ling; Huang, Duan; Zeng, Guihua

2018-05-01

This paper deals with a channel-parameter estimation for continuous-variable quantum key distribution (CV-QKD) over a satellite-to-submarine link. In particular, we focus on the channel transmittances and the excess noise which are affected by atmospheric turbulence, surface roughness, zenith angle of the satellite, wind speed, submarine depth, etc. The estimation method is based on proposed algorithms and is applied to low-Earth orbits using the Monte Carlo approach. For light at 550 nm with a repetition frequency of 1 MHz, the effects of the estimated parameters on the performance of the CV-QKD system are assessed by a simulation by comparing the secret key bit rate in the daytime and at night. Our results show the feasibility of satellite-to-submarine CV-QKD, providing an unconditionally secure approach to achieve global networks for underwater communications.

Advanced surface chemical analysis of continuously manufactured drug loaded composite pellets.

PubMed

Hossain, Akter; Nandi, Uttom; Fule, Ritesh; Nokhodchi, Ali; Maniruzzaman, Mohammed

2017-04-15

The aim of the present study was to develop and characterise polymeric composite pellets by means of continuous melt extrusion techniques. Powder blends of a steroid hormone (SH) as a model drug and either ethyl cellulose (EC N10 and EC P7 grades) or hydroxypropyl methylcellulose (HPMC AS grade) as polymeric carrier were extruded using a Pharma 11mm twin screw extruder in a continuous mode of operation to manufacture extruded composite pellets of 1mm length. Molecular modelling study using commercial Gaussian 09 software outlined a possible drug-polymer interaction in the molecular level to develop solid dispersions of the drug in the pellets. Solid-state analysis conducted via a differential scanning calorimetry (DSC), hot stage microscopy (HSM) and X-ray powder diffraction (XRPD) analyses revealed the amorphous state of the drug in the polymer matrices. Surface analysis using SEM/energy dispersive X-ray (EDX) of the produced pellets arguably showed a homogenous distribution of the C and O atoms in the pellet matrices. Moreover, advanced chemical surface analysis conducted via atomic force microscopy (AFM) showed a homogenous phase system having the drug molecule dispersed onto the amorphous matrices while Raman mapping confirmed the homogenous single-phase drug distribution in the manufactured composite pellets. Such composite pellets are expected to deliver multidisciplinary applications in drug delivery and medical sciences by e.g. modifying drug solubility/dissolutions or stabilizing the unstable drug (e.g. hormone, protein) in the composite network. Copyright © 2016. Published by Elsevier Inc.

Aerodynamic optimization by simultaneously updating flow variables and design parameters with application to advanced propeller designs

NASA Technical Reports Server (NTRS)

Rizk, Magdi H.

1988-01-01

A scheme is developed for solving constrained optimization problems in which the objective function and the constraint function are dependent on the solution of the nonlinear flow equations. The scheme updates the design parameter iterative solutions and the flow variable iterative solutions simultaneously. It is applied to an advanced propeller design problem with the Euler equations used as the flow governing equations. The scheme's accuracy, efficiency and sensitivity to the computational parameters are tested.

The Evolution of Health Care Advance Planning Law and Policy

PubMed Central

Sabatino, Charles P

2010-01-01

Context: The legal tools of health care advance planning have substantially changed since their emergence in the mid-1970s. Thirty years of policy development, primarily at the state legislative level addressing surrogate decision making and advance directives, have resulted in a disjointed policy landscape, yet with important points of convergence evolving over time. An understanding of the evolution of advance care planning policy has important implications for policy at both the state and federal levels. Methods: This article is a longitudinal statutory and literature review of health care advance planning from its origins to the present. Findings: While considerable variability across the states still remains, changes in law and policy over time suggest a gradual paradigm shift from what is described as a “legal transactional approach” to a “communications approach,” the most recent extension of which is the emergence of Physician Orders for Life-Sustaining Treatment, or POLST. The communications approach helps translate patients’ goals into visible and portable medical orders. Conclusions: States are likely to continue gradually moving away from a legal transactional mode of advance planning toward a communications model, albeit with challenges to authentic and reliable communication that accurately translates patients’ wishes into the care they receive. In the meantime, the states and their health care institutions will continue to serve as the primary laboratory for advance care planning policy and practice. PMID:20579283

The evolution of health care advance planning law and policy.

PubMed

Sabatino, Charles P

2010-06-01

The legal tools of health care advance planning have substantially changed since their emergence in the mid-1970s. Thirty years of policy development, primarily at the state legislative level addressing surrogate decision making and advance directives, have resulted in a disjointed policy landscape, yet with important points of convergence evolving over time. An understanding of the evolution of advance care planning policy has important implications for policy at both the state and federal levels. This article is a longitudinal statutory and literature review of health care advance planning from its origins to the present. While considerable variability across the states still remains, changes in law and policy over time suggest a gradual paradigm shift from what is described as a "legal transactional approach" to a "communications approach," the most recent extension of which is the emergence of Physician Orders for Life-Sustaining Treatment, or POLST. The communications approach helps translate patients' goals into visible and portable medical orders. States are likely to continue gradually moving away from a legal transactional mode of advance planning toward a communications model, albeit with challenges to authentic and reliable communication that accurately translates patients' wishes into the care they receive. In the meantime, the states and their health care institutions will continue to serve as the primary laboratory for advance care planning policy and practice.

Variable polarity arc welding

NASA Technical Reports Server (NTRS)

Bayless, E. O., Jr.

1991-01-01

Technological advances generate within themselves dissatisfactions that lead to further advances in a process. A series of advances in welding technology which culminated in the Variable Polarity Plasma Arc (VPPA) Welding Process and an advance instituted to overcome the latest dissatisfactions with the process: automated VPPA welding are described briefly.

A meta-analysis of variability in continuous-culture ruminal fermentation and digestibility data.

PubMed

Hristov, A N; Lee, C; Hristova, R; Huhtanen, P; Firkins, J L

2012-09-01

A meta-analysis was conducted to compare ruminal fermentation and digestibility data and variability between continuous-culture (CC) experiments and in vivo data. One hundred eighty CC studies representing 1,074 individual treatments, published in refereed journals between 1980 and 2010 were used in this analysis. Studies were classified into 2 groups based on the type of CC used: CC systems specified as rumen simulation techniques (RUSITEC) and non-RUSITEC CC systems (non-RUSITEC). The latter was a diverse group of systems, all of which were termed CC by the investigators. The CC data were compared with a data set of in vivo trials with ruminally cannulated lactating dairy cows (data from a total of 366 individual cows). The reported neutral detergent fiber (NDF) concentration of the diets fed in the 3 data sets was, on average (dry matter basis), 44, 34, and 32%, respectively. The average total volatile fatty acid (VFA) concentration for the RUSITEC and non-RUSITEC data sets was 67 and 80% (respectively) of the total VFA concentration in vivo. The average concentration of acetate was also lower for the CC data sets compared with in vivo and that of propionate was considerably lower for RUSITEC compared with in vivo, but butyrate concentrations were similar between the CC and in vivo data sets. Variability in the VFA data was generally the highest (higher coefficients of variation and variance) for the non-RUSITEC data set, followed by RUSITEC, and was the lowest for in vivo. Digestibilities of NDF and particularly organic matter were lower in the CC data sets compared with in vivo; the average NDF digestibility was 34.2, 45.5, and 53.0% for RUSITEC, non-RUSITEC, and in vivo, respectively. Variability in nutrient digestibility data followed the pattern of variability of the VFA data: highest variability for the non-RUSITEC data set, followed by RUSITEC, and the lowest for in vivo. This analysis showed that CC systems are generally characterized by lower total VFA

Advanced Intensity-Modulation Continuous-Wave Lidar Techniques for Column CO2 Measurements

NASA Astrophysics Data System (ADS)

Campbell, J. F.; Lin, B.; Obland, M. D.; Liu, Z.; Kooi, S. A.; Fan, T. F.; Nehrir, A. R.; Meadows, B.; Browell, E. V.

2016-12-01

Advanced Intensity-Modulation Continuous-Wave Lidar Techniques for Column CO2 MeasurementsJoel F. Campbell1, Bing Lin1, Michael D. Obland1, Zhaoyan Liu1, Susan Kooi2, Tai-Fang Fan2, Amin R. Nehrir1, Byron Meadows1, Edward V. Browell31NASA Langley Research Center, Hampton, VA 23681 2SSAI, NASA Langley Research Center, Hampton, VA 23681 3STARSS-II Affiliate, NASA Langley Research Center, Hampton, VA 23681 AbstractGlobal and regional atmospheric carbon dioxide (CO2) measurements for the NASA Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) space mission and the Atmospheric Carbon and Transport (ACT) - America project are critical for improving our understanding of global CO2 sources and sinks. Advanced Intensity-Modulated Continuous-Wave (IM-CW) lidar techniques are investigated as a means of facilitating CO2 measurements from space and airborne platforms to meet the ASCENDS and ACT-America science measurement requirements. In recent numerical, laboratory and flight experiments we have successfully used the Binary Phase Shift Keying (BPSK) modulation technique to uniquely discriminate surface lidar returns from intermediate aerosol and cloud returns. We demonstrate the utility of BPSK to eliminate sidelobes in the range profile as a means of making Integrated Path Differential Absorption (IPDA) column CO2 measurements in the presence of optically thin clouds, thereby minimizing bias errors caused by the clouds. Furthermore, high accuracy and precision ranging to the surface as well as to the top of intermediate cloud layers, which is a requirement for the inversion of column CO2 number density measurements to column CO2 mixing ratios, has been demonstrated using new sub-meter hyperfine interpolation techniques that takes advantage of the periodicity of the modulation waveforms. The BPSK technique under investigation has excellent auto-correlation properties while possessing a finite bandwidth. These techniques are used in a new data processing

Constant versus variable response signal delays in speed--accuracy trade-offs: effects of advance preparation for processing time.

PubMed

Miller, Jeff; Sproesser, Gudrun; Ulrich, Rolf

2008-07-01

In two experiments, we used response signals (RSs) to control processing time and trace out speed--accuracy trade-off(SAT) functions in a difficult perceptual discrimination task. Each experiment compared performance in blocks of trials with constant and, hence, temporally predictable RS lags against performance in blocks with variable, unpredictable RS lags. In both experiments, essentially equivalent SAT functions were observed with constant and variable RS lags. We conclude that there is little effect of advance preparation for a given processing time, suggesting that the discrimination mechanisms underlying SAT functions are driven solely by bottom-up information processing in perceptual discrimination tasks.

Advanced supersonic propulsion study, phase 2. [propulsion system performance, design analysis and technology assessment

NASA Technical Reports Server (NTRS)

Howlett, R. A.

1975-01-01

A continuation of the NASA/P and WA study to evaluate various types of propulsion systems for advanced commercial supersonic transports has resulted in the identification of two very promising engine concepts. They are the Variable Stream Control Engine which provides independent temperature and velocity control for two coannular exhaust streams, and a derivative of this engine, a Variable Cycle Engine that employs a rear flow-inverter valve to vary the bypass ratio of the cycle. Both concepts are based on advanced engine technology and have the potential for significant improvements in jet noise, exhaust emissions and economic characteristics relative to current technology supersonic engines. Extensive research and technology programs are required in several critical areas that are unique to these supersonic Variable Cycle Engines to realize these potential improvements. Parametric cycle and integration studies of conventional and Variable Cycle Engines are reviewed, features of the two most promising engine concepts are described, and critical technology requirements and required programs are summarized.

The Mediating Roles of Internal Context Variables in the Relationship between Distributed Leadership Perceptions and Continuous Change Behaviours of Public School Teachers

ERIC Educational Resources Information Center

Kondakci, Yasar; Zayim, Merve; Beycioglu, Kadir; Sincar, Mehmet; Ugurlu, Celal T

2016-01-01

This study aims at building a theoretical base for continuous change in education and using this base to test the mediating roles of two key contextual variables, knowledge sharing and trust, in the relationship between the distributed leadership perceptions and continuous change behaviours of teachers. Data were collected from 687 public school…

Optimally setting up directed searches for continuous gravitational waves in Advanced LIGO O1 data

NASA Astrophysics Data System (ADS)

Ming, Jing; Papa, Maria Alessandra; Krishnan, Badri; Prix, Reinhard; Beer, Christian; Zhu, Sylvia J.; Eggenstein, Heinz-Bernd; Bock, Oliver; Machenschalk, Bernd

2018-02-01

In this paper we design a search for continuous gravitational waves from three supernova remnants: Vela Jr., Cassiopeia A (Cas A) and G347.3. These systems might harbor rapidly rotating neutron stars emitting quasiperiodic gravitational radiation detectable by the advanced LIGO detectors. Our search is designed to use the volunteer computing project Einstein@Home for a few months and assumes the sensitivity and duty cycles of the advanced LIGO detectors during their first science run. For all three supernova remnants, the sky positions of their central compact objects are well known but the frequency and spin-down rates of the neutron stars are unknown which makes the searches computationally limited. In a previous paper we have proposed a general framework for deciding on what target we should spend computational resources and in what proportion, what frequency and spin-down ranges we should search for every target, and with what search setup. Here we further expand this framework and apply it to design a search directed at detecting continuous gravitational wave signals from the most promising three supernova remnants identified as such in the previous work. Our optimization procedure yields broad frequency and spin-down searches for all three objects, at an unprecedented level of sensitivity: The smallest detectable gravitational wave strain h0 for Cas A is expected to be 2 times smaller than the most sensitive upper limits published to date, and our proposed search, which was set up and ran on the volunteer computing project Einstein@Home, covers a much larger frequency range.

Single-photon continuous-variable quantum key distribution based on the energy-time uncertainty relation.

PubMed

Qi, Bing

2006-09-15

We propose a new quantum key distribution protocol in which information is encoded on continuous variables of a single photon. In this protocol, Alice randomly encodes her information on either the central frequency of a narrowband single-photon pulse or the time delay of a broadband single-photon pulse, while Bob randomly chooses to do either frequency measurement or time measurement. The security of this protocol rests on the energy-time uncertainty relation, which prevents Eve from simultaneously determining both frequency and time information with arbitrarily high resolution. Since no interferometer is employed in this scheme, it is more robust against various channel noises, such as polarization and phase fluctuations.

Continuous variable quantum key distribution: finite-key analysis of composable security against coherent attacks.

PubMed

Furrer, F; Franz, T; Berta, M; Leverrier, A; Scholz, V B; Tomamichel, M; Werner, R F

2012-09-07

We provide a security analysis for continuous variable quantum key distribution protocols based on the transmission of two-mode squeezed vacuum states measured via homodyne detection. We employ a version of the entropic uncertainty relation for smooth entropies to give a lower bound on the number of secret bits which can be extracted from a finite number of runs of the protocol. This bound is valid under general coherent attacks, and gives rise to keys which are composably secure. For comparison, we also give a lower bound valid under the assumption of collective attacks. For both scenarios, we find positive key rates using experimental parameters reachable today.

A preliminary design and analysis of an advanced heat-rejection system for an extreme altitude advanced variable cycle diesel engine installed in a high-altitude advanced research platform

NASA Technical Reports Server (NTRS)

Johnston, Richard P.

1992-01-01

Satellite surveillance in such areas as the Antarctic indicates that from time to time concentration of ozone grows and shrinks. An effort to obtain useful atmospheric data for determining the causes of ozone depletion would require a flight capable of reaching altitudes of at least 100,000 ft and flying subsonically during the sampling portion of the mission. A study of a heat rejection system for an advanced variable cycle diesel (AVCD) engine was conducted. The engine was installed in an extreme altitude, high altitude advanced research platform. Results indicate that the waste heat from an AVCD engine propulsion system can be rejected at the maximum cruise altitude of 120,000 ft. Fifteen performance points, reflecting the behavior of the engine as the vehicle proceeded through the mission, were used to characterize the heat exchanger operation. That portion of the study is described in a appendix titled, 'A Detailed Study of the Heat Rejection System for an Extreme Altitude Atmospheric Sampling Aircraft,' by a consultant, Mr. James Bourne, Lytron, Incorporated.

Advances in Statistical Methods for Substance Abuse Prevention Research

PubMed Central

MacKinnon, David P.; Lockwood, Chondra M.

2010-01-01

The paper describes advances in statistical methods for prevention research with a particular focus on substance abuse prevention. Standard analysis methods are extended to the typical research designs and characteristics of the data collected in prevention research. Prevention research often includes longitudinal measurement, clustering of data in units such as schools or clinics, missing data, and categorical as well as continuous outcome variables. Statistical methods to handle these features of prevention data are outlined. Developments in mediation, moderation, and implementation analysis allow for the extraction of more detailed information from a prevention study. Advancements in the interpretation of prevention research results include more widespread calculation of effect size and statistical power, the use of confidence intervals as well as hypothesis testing, detailed causal analysis of research findings, and meta-analysis. The increased availability of statistical software has contributed greatly to the use of new methods in prevention research. It is likely that the Internet will continue to stimulate the development and application of new methods. PMID:12940467

Joint weak value for all order coupling using continuous variable and qubit probe

NASA Astrophysics Data System (ADS)

Kumari, Asmita; Pan, Alok Kumar; Panigrahi, Prasanta K.

2017-11-01

The notion of weak measurement in quantum mechanics has gained a significant and wide interest in realizing apparently counterintuitive quantum effects. In recent times, several theoretical and experimental works have been reported for demonstrating the joint weak value of two observables where the coupling strength is restricted to the second order. In this paper, we extend such a formulation by providing a complete treatment of joint weak measurement scenario for all-order-coupling for the observable satisfying A 2 = 𝕀 and A 2 = A, which allows us to reveal several hitherto unexplored features. By considering the probe state to be discrete as well as continuous variable, we demonstrate how the joint weak value can be inferred for any given strength of the coupling. A particularly interesting result we pointed out that even if the initial pointer state is uncorrelated, the single pointer displacement can provide the information about the joint weak value, if at least third order of the coupling is taken into account. As an application of our scheme, we provide an all-order-coupling treatment of the well-known Hardy paradox by considering the continuous as well as discrete meter states and show how the negative joint weak probabilities emerge in the quantum paradoxes at the weak coupling limit.

The Continued Assessment of Self-Continuity and Identity

ERIC Educational Resources Information Center

Dunkel, Curtis S.; Minor, Leslie; Babineau, Maureen

2010-01-01

Studies have found that self-continuity is predictive of a substantial number of important outcome variables. However, a recent series of studies brings into question the traditional method of measuring self-continuity in favor of an alternative (B. M. Baird, K. Le, & R. E. Lucas, 2006). The present study represents a further comparison of…

STUDY ON A STEP-ADVANCED FILTER MONITOR FOR CONTINUOUS RADON PROGENY MEASUREMENT.

PubMed

Zhang, Lei; Yang, Jinmin; Guo, Qiuju

2017-04-01

Traditional fixed-filter radon progeny monitors are usually clogged with the loading of dust and cannot be used for radon progeny continuous measurement for long period. To solve this problem, a step-advanced filter (SAF) monitor for radon progeny measurement was developed. This monitor automatically roll and stop the filter at each interview. Radon progeny is collected on a 'fresh' filter at a flowrate of 3 L/min. At the same time, alpha and beta particles emitted from filter are recorded by a PIPS detector. A newly developed alpha-beta spectrum method was used for radon progeny concentration calculation. The 218Po, 214Pb and 214Bi concentrations as well as equilibrium equivalent concentration (EEC) could be worked out at the same time. The lower level limit detection of this monitor is 0.48 Bq m-3 (EEC) for 1h interval. Comparison experiments were carried out in the radon chamber at the National Institute of Metrology of China. The measurement results of this SAF monitor are consistent with EQF3220 (SARAD GmbH, Germany), and the uncertainty is smaller. Due to its high sensitivity, the periodical variation of radon progeny concentration can be easily observed by this monitor. The SAF moniter is suitable for continuous measurement in both indoor and outdoor environments. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Improving the maximum transmission distance of continuous-variable quantum key distribution using a noiseless amplifier

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blandino, Rémi; Etesse, Jean; Grangier, Philippe

2014-12-04

We show that the maximum transmission distance of continuous-variable quantum key distribution in presence of a Gaussian noisy lossy channel can be arbitrarily increased using a heralded noiseless linear amplifier. We explicitly consider a protocol using amplitude and phase modulated coherent states with reverse reconciliation. Assuming that the secret key rate drops to zero for a line transmittance T{sub lim}, we find that a noiseless amplifier with amplitude gain g can improve this value to T{sub lim}/g{sup 2}, corresponding to an increase in distance proportional to log g. We also show that the tolerance against noise is increased.

Five-wave-packet quantum error correction based on continuous-variable cluster entanglement

PubMed Central

Hao, Shuhong; Su, Xiaolong; Tian, Caixing; Xie, Changde; Peng, Kunchi

2015-01-01

Quantum error correction protects the quantum state against noise and decoherence in quantum communication and quantum computation, which enables one to perform fault-torrent quantum information processing. We experimentally demonstrate a quantum error correction scheme with a five-wave-packet code against a single stochastic error, the original theoretical model of which was firstly proposed by S. L. Braunstein and T. A. Walker. Five submodes of a continuous variable cluster entangled state of light are used for five encoding channels. Especially, in our encoding scheme the information of the input state is only distributed on three of the five channels and thus any error appearing in the remained two channels never affects the output state, i.e. the output quantum state is immune from the error in the two channels. The stochastic error on a single channel is corrected for both vacuum and squeezed input states and the achieved fidelities of the output states are beyond the corresponding classical limit. PMID:26498395

Phase-noise limitations in continuous-variable quantum key distribution with homodyne detection

NASA Astrophysics Data System (ADS)

Corvaja, Roberto

2017-02-01

In continuous-variables quantum key distribution with coherent states, the advantage of performing the detection by using standard telecoms components is counterbalanced by the lack of a stable phase reference in homodyne detection due to the complexity of optical phase-locking circuits and to the unavoidable phase noise of lasers, which introduces a degradation on the achievable secure key rate. Pilot-assisted phase-noise estimation and postdetection compensation techniques are used to implement a protocol with coherent states where a local laser is employed and it is not locked to the received signal, but a postdetection phase correction is applied. Here the reduction of the secure key rate determined by the laser phase noise, for both individual and collective attacks, is analytically evaluated and a scheme of pilot-assisted phase estimation proposed, outlining the tradeoff in the system design between phase noise and spectral efficiency. The optimal modulation variance as a function of the phase-noise amount is derived.

Experimental study on all-fiber-based unidimensional continuous-variable quantum key distribution

NASA Astrophysics Data System (ADS)

Wang, Xuyang; Liu, Wenyuan; Wang, Pu; Li, Yongmin

2017-06-01

We experimentally demonstrated an all-fiber-based unidimensional continuous-variable quantum key distribution (CV QKD) protocol and analyzed its security under collective attack in realistic conditions. A pulsed balanced homodyne detector, which could not be accessed by eavesdroppers, with phase-insensitive efficiency and electronic noise, was considered. Furthermore, a modulation method and an improved relative phase-locking technique with one amplitude modulator and one phase modulator were designed. The relative phase could be locked precisely with a standard deviation of 0.5° and a mean of almost zero. Secret key bit rates of 5.4 kbps and 700 bps were achieved for transmission fiber lengths of 30 and 50 km, respectively. The protocol, which simplified the CV QKD system and reduced the cost, displayed a performance comparable to that of a symmetrical counterpart under realistic conditions. It is expected that the developed protocol can facilitate the practical application of the CV QKD.

Ancilla-driven quantum computation for qudits and continuous variables

DOE PAGES

Proctor, Timothy; Giulian, Melissa; Korolkova, Natalia; ...

2017-05-10

Although qubits are the leading candidate for the basic elements in a quantum computer, there are also a range of reasons to consider using higher-dimensional qudits or quantum continuous variables (QCVs). In this paper, we use a general “quantum variable” formalism to propose a method of quantum computation in which ancillas are used to mediate gates on a well-isolated “quantum memory” register and which may be applied to the setting of qubits, qudits (for d>2), or QCVs. More specifically, we present a model in which universal quantum computation may be implemented on a register using only repeated applications of amore » single fixed two-body ancilla-register interaction gate, ancillas prepared in a single state, and local measurements of these ancillas. In order to maintain determinism in the computation, adaptive measurements via a classical feed forward of measurement outcomes are used, with the method similar to that in measurement-based quantum computation (MBQC). We show that our model has the same hybrid quantum-classical processing advantages as MBQC, including the power to implement any Clifford circuit in essentially one layer of quantum computation. In some physical settings, high-quality measurements of the ancillas may be highly challenging or not possible, and hence we also present a globally unitary model which replaces the need for measurements of the ancillas with the requirement for ancillas to be prepared in states from a fixed orthonormal basis. In conclusion, we discuss settings in which these models may be of practical interest.« less

Regional cooling caused recent New Zealand glacier advances in a period of global warming.

PubMed

Mackintosh, Andrew N; Anderson, Brian M; Lorrey, Andrew M; Renwick, James A; Frei, Prisco; Dean, Sam M

2017-02-14

Glaciers experienced worldwide retreat during the twentieth and early twenty first centuries, and the negative trend in global glacier mass balance since the early 1990s is predominantly a response to anthropogenic climate warming. The exceptional terminus advance of some glaciers during recent global warming is thought to relate to locally specific climate conditions, such as increased precipitation. In New Zealand, at least 58 glaciers advanced between 1983 and 2008, and Franz Josef and Fox glaciers advanced nearly continuously during this time. Here we show that the glacier advance phase resulted predominantly from discrete periods of reduced air temperature, rather than increased precipitation. The lower temperatures were associated with anomalous southerly winds and low sea surface temperature in the Tasman Sea region. These conditions result from variability in the structure of the extratropical atmospheric circulation over the South Pacific. While this sequence of climate variability and its effect on New Zealand glaciers is unusual on a global scale, it remains consistent with a climate system that is being modified by humans.

Regional cooling caused recent New Zealand glacier advances in a period of global warming

NASA Astrophysics Data System (ADS)

Mackintosh, Andrew N.; Anderson, Brian M.; Lorrey, Andrew M.; Renwick, James A.; Frei, Prisco; Dean, Sam M.

2017-02-01

Glaciers experienced worldwide retreat during the twentieth and early twenty first centuries, and the negative trend in global glacier mass balance since the early 1990s is predominantly a response to anthropogenic climate warming. The exceptional terminus advance of some glaciers during recent global warming is thought to relate to locally specific climate conditions, such as increased precipitation. In New Zealand, at least 58 glaciers advanced between 1983 and 2008, and Franz Josef and Fox glaciers advanced nearly continuously during this time. Here we show that the glacier advance phase resulted predominantly from discrete periods of reduced air temperature, rather than increased precipitation. The lower temperatures were associated with anomalous southerly winds and low sea surface temperature in the Tasman Sea region. These conditions result from variability in the structure of the extratropical atmospheric circulation over the South Pacific. While this sequence of climate variability and its effect on New Zealand glaciers is unusual on a global scale, it remains consistent with a climate system that is being modified by humans.

Regional cooling caused recent New Zealand glacier advances in a period of global warming

PubMed Central

Mackintosh, Andrew N.; Anderson, Brian M.; Lorrey, Andrew M.; Renwick, James A.; Frei, Prisco; Dean, Sam M.

2017-01-01

Glaciers experienced worldwide retreat during the twentieth and early twenty first centuries, and the negative trend in global glacier mass balance since the early 1990s is predominantly a response to anthropogenic climate warming. The exceptional terminus advance of some glaciers during recent global warming is thought to relate to locally specific climate conditions, such as increased precipitation. In New Zealand, at least 58 glaciers advanced between 1983 and 2008, and Franz Josef and Fox glaciers advanced nearly continuously during this time. Here we show that the glacier advance phase resulted predominantly from discrete periods of reduced air temperature, rather than increased precipitation. The lower temperatures were associated with anomalous southerly winds and low sea surface temperature in the Tasman Sea region. These conditions result from variability in the structure of the extratropical atmospheric circulation over the South Pacific. While this sequence of climate variability and its effect on New Zealand glaciers is unusual on a global scale, it remains consistent with a climate system that is being modified by humans. PMID:28195582

Controlling Continuous-Variable Quantum Key Distribution with Entanglement in the Middle Using Tunable Linear Optics Cloning Machines

NASA Astrophysics Data System (ADS)

Wu, Xiao Dong; Chen, Feng; Wu, Xiang Hua; Guo, Ying

2017-02-01

Continuous-variable quantum key distribution (CVQKD) can provide detection efficiency, as compared to discrete-variable quantum key distribution (DVQKD). In this paper, we demonstrate a controllable CVQKD with the entangled source in the middle, contrast to the traditional point-to-point CVQKD where the entanglement source is usually created by one honest party and the Gaussian noise added on the reference partner of the reconciliation is uncontrollable. In order to harmonize the additive noise that originates in the middle to resist the effect of malicious eavesdropper, we propose a controllable CVQKD protocol by performing a tunable linear optics cloning machine (LOCM) at one participant's side, say Alice. Simulation results show that we can achieve the optimal secret key rates by selecting the parameters of the tuned LOCM in the derived regions.

A Continued Census of Mid-IR Variability from ULXs

NASA Astrophysics Data System (ADS)

Lau, Ryan; Kasliwal, Mansi; Heida, Marianne; Walton, Dom

2017-04-01

The nature of ultraluminous X-ray sources (ULXs) that radiate at luminosities >10^39 erg/s is still a mystery. ULXs are believed to be binaries with an accreting compact object and stellar mass-donor companion, but such high luminosities require accretion rates that are factors of 100 greater than the Eddington limit for accretion onto a neutron star or stellar mass black hole. The difficulties in interpreting ULXs are largely attributed to current observational challenges in determining their orbital properties as well as the properties of the mass-donor companion. Recently, near- and mid-infrared (IR) observations have been demonstrated as powerful diagnostics of the mass-donor companion and the circumstellar environment of ULXs. For example, serendipitous Spitzer/IRAC observations of the ULX Holmberg II X-1 in our Spitzer Infrared Intensive Transients Survey (SPIRITS) revealed the first detection of mid-IR variability from a ULX, where we claimed that the mid-IR emission arises from a dusty circumbinary torus in the winds of a supergiant B[e] mass-donor companion. We identified 5 additional mid-IR ULX counterparts detected by Spitzer/IRAC, one of which shows significant variability like Holmberg II X-1. Although we are finding a growing sample of ULXs exhibiting mid-IR variability, it is unclear what causes it. Notably, the week - year cadence baselines of the SPIRITS observations are inadequate for resolving variability timescales consistent with several observed ULX orbital periods. In this proposal, we request time-series observations of 6 ULXs with cadence baselines ranging from 0.5 days to 1 week in order to identify the timescales associated mid-IR variability.

Continuous-variable measurement-device-independent quantum key distribution: Composable security against coherent attacks

NASA Astrophysics Data System (ADS)

Lupo, Cosmo; Ottaviani, Carlo; Papanastasiou, Panagiotis; Pirandola, Stefano

2018-05-01

We present a rigorous security analysis of continuous-variable measurement-device-independent quantum key distribution (CV MDI QKD) in a finite-size scenario. The security proof is obtained in two steps: by first assessing the security against collective Gaussian attacks, and then extending to the most general class of coherent attacks via the Gaussian de Finetti reduction. Our result combines recent state-of-the-art security proofs for CV QKD with findings about min-entropy calculus and parameter estimation. In doing so, we improve the finite-size estimate of the secret key rate. Our conclusions confirm that CV MDI protocols allow for high rates on the metropolitan scale, and may achieve a nonzero secret key rate against the most general class of coherent attacks after 107-109 quantum signal transmissions, depending on loss and noise, and on the required level of security.

Neoadjuvant chemotherapy with continuous infusion of cisplatin and 5-fluorouracil, with or without leucovorin, for locally advanced nasopharyngeal carcinoma.

PubMed

Fonseca, E; Cruz, J J; Rodríguez, C A; Gómez-Bernal, A; Martín, G; Sánchez, P; Nieto, A; Soria, P; Vega, M J; Muñoz, A; Pardal, J L

1996-01-01

Cisplatin-based induction chemotherapy has been extensively tested in nasopharyngeal carcinoma for the improvement of local and systemic control and survival of this disease. In this study, we report the results of the treatment with induction chemotherapy in 40 patients with locally advanced carcinoma of the nasopharynx (LANPC) with four courses of cisplatin (P) 25 mg/m2 per day and 5-fluorouracil (F) 1000 mg/m2 per day both in a 4-days continuous infusion, with or without leucovorin (L) 250 mg/m2 per day in 2-hour infusion at the beginning of daily administration of PF, followed by sequential radiotherapy. All except one were in stage IV. The overall response after induction chemotherapy was 93%, with 55% CR and 38% PR. Definitive overall response after radiotherapy was 98%, with 80% CR and 18% PR. At a maximum follow up of 11 years, the overall survival rate is 55%. Induction chemotherapy with continuous infusion of PF with or without leucovorin followed by radiotherapy is a highly active regimen for the treatment of locally advanced nasopharyngeal carcinoma with response and survival rates comparable to other combinations of sequential or simultaneous chemotherapy and radiotherapy.

The Danger of Dichotomizing Continuous Variables: A Visualization

ERIC Educational Resources Information Center

Kuss, Oliver

2013-01-01

Four rather different scatterplots of two variables X and Y are given, which, after dichotomizing X and Y, result in identical fourfold-tables misleadingly showing no association. (Contains 1 table and 1 figure.)

Continuous-variable entanglement and quantum-state teleportation between optical and macroscopic vibrational modes through radiation pressure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pirandola, Stefano; Mancini, Stefano; Vitali, David

2003-12-01

We study an isolated, perfectly reflecting, mirror illuminated by an intense laser pulse. We show that the resulting radiation pressure efficiently entangles a mirror vibrational mode with the two reflected optical sideband modes of the incident carrier beam. The entanglement of the resulting three-mode state is studied in detail and it is shown to be robust against the mirror mode temperature. We then show how this continuous-variable entanglement can be profitably used to teleport an unknown quantum state of an optical mode onto the vibrational mode of the mirror.

Hepatocellular carcinoma: Advances in diagnostic imaging.

PubMed

Sun, Haoran; Song, Tianqiang

2015-10-01

Thanks to the growing knowledge on biological behaviors of hepatocellular carcinomas (HCC), as well as continuous improvement in imaging techniques and experienced interpretation of imaging features of the nodules in cirrhotic liver, the detection and characterization of HCC has improved in the past decade. A number of practice guidelines for imaging diagnosis have been developed to reduce interpretation variability and standardize management of HCC, and they are constantly updated with advances in imaging techniques and evidence based data from clinical series. In this article, we strive to review the imaging techniques and the characteristic features of hepatocellular carcinoma associated with cirrhotic liver, with emphasis on the diagnostic value of advanced magnetic resonance imaging (MRI) techniques and utilization of hepatocyte-specific MRI contrast agents. We also briefly describe the concept of liver imaging reporting and data systems and discuss the consensus and controversy of major practice guidelines.

Control system and method for a power delivery system having a continuously variable ratio transmission

DOEpatents

Frank, A.A.

1984-07-10

A control system and method for a power delivery system, such as in an automotive vehicle, having an engine coupled to a continuously variable ratio transmission (CVT). Totally independent control of engine and transmission enable the engine to precisely follow a desired operating characteristic, such as the ideal operating line for minimum fuel consumption. CVT ratio is controlled as a function of commanded power or torque and measured load, while engine fuel requirements (e.g., throttle position) are strictly a function of measured engine speed. Fuel requirements are therefore precisely adjusted in accordance with the ideal characteristic for any load placed on the engine. 4 figs.

Comparative study on performances of a continuously variable transmission used in two different powertrain architectures

NASA Astrophysics Data System (ADS)

Sibiceanu, A. R.; Ivan, F.; Nicolae, V.; Iorga, A.; Cioroianu, C.

2017-08-01

Given the importance of reducing carbon emissions from road transport, price and security of oil supply, hybrid electric vehicle can provide a viable alternative solution to conventional vehicles, equipped with thermal engines, which use fossil fuels. Based on the growing trends of new vehicles sales, which include hybrid and electric vehicles closely associated with their use in terms of harmful emissions, strict regulations are established. In this paper were created models of thermal and hybrid electric powertrains groups, using computer simulation program AVL Cruise, making a comparative study using petroleum fuels for continuously variable transmission. The results obtained highlights both fuel consumption as well as pollutant emissions.

Control system and method for a power delivery system having a continuously variable ratio transmission

DOEpatents

Frank, Andrew A.

1984-01-01

A control system and method for a power delivery system, such as in an automotive vehicle, having an engine coupled to a continuously variable ratio transmission (CVT). Totally independent control of engine and transmission enable the engine to precisely follow a desired operating characteristic, such as the ideal operating line for minimum fuel consumption. CVT ratio is controlled as a function of commanded power or torque and measured load, while engine fuel requirements (e.g., throttle position) are strictly a function of measured engine speed. Fuel requirements are therefore precisely adjusted in accordance with the ideal characteristic for any load placed on the engine.

Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables.

PubMed

Seddon, Johanna M; Reynolds, Robyn; Maller, Julian; Fagerness, Jesen A; Daly, Mark J; Rosner, Bernard

2009-05-01

The joint effects of genetic, ocular, and environmental variables were evaluated and predictive models for prevalence and incidence of AMD were assessed. Participants in the multicenter Age-Related Eye Disease Study (AREDS) were included in a prospective evaluation of 1446 individuals, of which 279 progressed to advanced AMD (geographic atrophy or neovascular disease) and 1167 did not progress during 6.3 years of follow-up. For prevalent AMD, 509 advanced cases were compared with 222 controls. Covariates for the incidence analysis included age, sex, education, smoking, body mass index (BMI), baseline AMD grade, and the AREDS vitamin-mineral treatment assignment. DNA specimens were evaluated for six variants in five genes related to AMD. Unconditional logistic regression analyses were performed for prevalent and incident advanced AMD. An algorithm was developed and receiver operating characteristic curves and C statistics were calculated to assess the predictive ability of risk scores to discriminate progressors from nonprogressors. All genetic polymorphisms were independently related to prevalence of advanced AMD, controlling for genetic factors, smoking, BMI, and AREDS treatment. Multivariate odds ratios (ORs) were 3.5 (95% confidence interval [CI], 1.7-7.1) for CFH Y402H; 3.7 (95% CI, 1.6-8.4) for CFH rs1410996; 25.4 (95% CI, 8.6-75.1) for LOC387715 A69S (ARMS2); 0.3 (95% CI, 0.1-0.7) for C2 E318D; 0.3 (95% CI, 0.1-0.5) for CFB; and 3.6 (95% CI, 1.4-9.4) for C3 R102G, comparing the homozygous risk/protective genotypes to the referent genotypes. For incident AMD, all these variants except CFB were significantly related to progression to advanced AMD, after controlling for baseline AMD grade and other factors, with ORs from 1.8 to 4.0 for presence of two risk alleles and 0.4 for the protective allele. An interaction was seen between CFH402H and treatment, after controlling for all genotypes. Smoking was independently related to AMD, with a multiplicative joint

Continuous-variable quantum key distribution based on a plug-and-play dual-phase-modulated coherent-states protocol

NASA Astrophysics Data System (ADS)

Huang, Duan; Huang, Peng; Wang, Tao; Li, Huasheng; Zhou, Yingming; Zeng, Guihua

2016-09-01

We propose and experimentally demonstrate a continuous-variable quantum key distribution (CV-QKD) protocol using dual-phase-modulated coherent states. We show that the modulation scheme of our protocol works equivalently to that of the Gaussian-modulated coherent-states (GMCS) protocol, but shows better experimental feasibility in the plug-and-play configuration. Besides, it waives the necessity of propagation of a local oscillator (LO) between legitimate users and generates a real local LO for quantum measurement. Our protocol is proposed independent of the one-way GMCS QKD without sending a LO [Opt. Lett. 40, 3695 (2015), 10.1364/OL.40.003695; Phys. Rev. X 5, 041009 (2015), 10.1103/PhysRevX.5.041009; Phys. Rev. X 5, 041010 (2015), 10.1103/PhysRevX.5.041010]. In those recent works, the system stability will suffer the impact of polarization drifts induced by environmental perturbations, and two independent frequency-locked laser sources are necessary to achieve reliable coherent detection. In the proposed protocol, these previous problems can be resolved. We derive the security bounds for our protocol against collective attacks, and we also perform a proof-of-principle experiment to confirm the utility of our proposal in real-life applications. Such an efficient scheme provides a way of removing the security loopholes associated with the transmitting LO, which have been a notoriously hard problem in continuous-variable quantum communication.

Ultra-high-speed variable focus optics for novel applications in advanced imaging

NASA Astrophysics Data System (ADS)

Kang, S.; Dotsenko, E.; Amrhein, D.; Theriault, C.; Arnold, C. B.

2018-02-01

With the advancement of ultra-fast manufacturing technologies, high speed imaging with high 3D resolution has become increasingly important. Here we show the use of an ultra-high-speed variable focus optical element, the TAG Lens, to enable new ways to acquire 3D information from an object. The TAG Lens uses sound to adjust the index of refraction profile in a liquid and thereby can achieve focal scanning rates greater than 100 kHz. When combined with a high-speed pulsed LED and a high-speed camera, we can exploit this phenomenon to achieve high-resolution imaging through large depths. By combining the image acquisition with digital image processing, we can extract relevant parameters such as tilt and angle information from objects in the image. Due to the high speeds at which images can be collected and processed, we believe this technique can be used as an efficient method of industrial inspection and metrology for high throughput applications.

Benefits of advanced propulsion technology for the advanced supersonic transport

NASA Technical Reports Server (NTRS)

Hines, R. W.; Sabatella, J. A.

1973-01-01

Future supersonic transports will have to provide improvement in the areas of economics, range, and emissions relative to the present generation of supersonic transports, as well as meeting or improving upon FAR 36 noise goals. This paper covers the promising propulsion systems including variable-cycle engine concepts for long-range supersonic commercial transport application. The benefits of applying advanced propulsion technology to solve the economic and environmental problems are reviewed. The advanced propulsion technologies covered are in the areas of structures, materials, cooling techniques, aerodynamics, variable engine geometry, jet noise suppressors, acoustic treatment, and low-emission burners. The results of applying the advanced propulsion technology are presented in terms of improvement in overall system takeoff gross weight and return on investment.

Quantifying temporal glucose variability in diabetes via continuous glucose monitoring: mathematical methods and clinical application.

PubMed

Kovatchev, Boris P; Clarke, William L; Breton, Marc; Brayman, Kenneth; McCall, Anthony

2005-12-01

Continuous glucose monitors (CGMs) collect detailed blood glucose (BG) time series, which carry significant information about the dynamics of BG fluctuations. In contrast, the methods for analysis of CGM data remain those developed for infrequent BG self-monitoring. As a result, important information about the temporal structure of the data is lost during the translation of raw sensor readings into clinically interpretable statistics and images. The following mathematical methods are introduced into the field of CGM data interpretation: (1) analysis of BG rate of change; (2) risk analysis using previously reported Low/High BG Indices and Poincare (lag) plot of risk associated with temporal BG variability; and (3) spatial aggregation of the process of BG fluctuations and its Markov chain visualization. The clinical application of these methods is illustrated by analysis of data of a patient with Type 1 diabetes mellitus who underwent islet transplantation and with data from clinical trials. Normative data [12,025 reference (YSI device, Yellow Springs Instruments, Yellow Springs, OH) BG determinations] in patients with Type 1 diabetes mellitus who underwent insulin and glucose challenges suggest that the 90%, 95%, and 99% confidence intervals of BG rate of change that could be maximally sustained over 15-30 min are [-2,2], [-3,3], and [-4,4] mg/dL/min, respectively. BG dynamics and risk parameters clearly differentiated the stages of transplantation and the effects of medication. Aspects of treatment were clearly visualized by graphs of BG rate of change and Low/High BG Indices, by a Poincare plot of risk for rapid BG fluctuations, and by a plot of the aggregated Markov process. Advanced analysis and visualization of CGM data allow for evaluation of dynamical characteristics of diabetes and reveal clinical information that is inaccessible via standard statistics, which do not take into account the temporal structure of the data. The use of such methods improves the

Variable order fractional Fokker-Planck equations derived from Continuous Time Random Walks

NASA Astrophysics Data System (ADS)

Straka, Peter

2018-08-01

Continuous Time Random Walk models (CTRW) of anomalous diffusion are studied, where the anomalous exponent β(x) ∈(0 , 1) varies in space. This type of situation occurs e.g. in biophysics, where the density of the intracellular matrix varies throughout a cell. Scaling limits of CTRWs are known to have probability distributions which solve fractional Fokker-Planck type equations (FFPE). This correspondence between stochastic processes and FFPE solutions has many useful extensions e.g. to nonlinear particle interactions and reactions, but has not yet been sufficiently developed for FFPEs of the "variable order" type with non-constant β(x) . In this article, variable order FFPEs (VOFFPE) are derived from scaling limits of CTRWs. The key mathematical tool is the 1-1 correspondence of a CTRW scaling limit to a bivariate Langevin process, which tracks the cumulative sum of jumps in one component and the cumulative sum of waiting times in the other. The spatially varying anomalous exponent is modelled by spatially varying β(x) -stable Lévy noise in the waiting time component. The VOFFPE displays a spatially heterogeneous temporal scaling behaviour, with generalized diffusivity and drift coefficients whose units are length2/timeβ(x) resp. length/timeβ(x). A global change of the time scale results in a spatially varying change in diffusivity and drift. A consequence of the mathematical derivation of a VOFFPE from CTRW limits in this article is that a solution of a VOFFPE can be approximated via Monte Carlo simulations. Based on such simulations, we are able to confirm that the VOFFPE is consistent under a change of the global time scale.

Evaluating the Efficacy of Nocturnal Continuous Subcutaneous Apomorphine Infusion in Sleep Disorders in Advanced Parkinson's Disease: The APO-NIGHT Study.

PubMed

Fernández-Pajarín, Gustavo; Sesar, Ángel; Ares, Begoña; Castro, Alfonso

2016-10-19

There are not many data about the beneficial effect of nocturnal continuous subcutaneous apomorphine infusion (NCSAI) over sleep disturbances in advanced Parkinson's disease (PD). Evaluate the effect of the NCSAI in sleeping problems and insomnia due to nocturnal hypokinesia inadvanced PD. We assessed 17 advanced PD patients with several sleep disturbances measured by SCOPA-SLEEP and PDSS scales. All the patients were on apomorphine infusion during daytime. This therapy was extended to nighttime. We evaluated the patients before the onset and after six weeks with NCSAI. NCSAI allowed highly significant improvements in SCOPA-SLEEP and PDSS scales (p<0.0001), and daytime somnolence. NCSAI was well tolerated with no major adverse effects were noticed. This study shows and confirms the efficacy of NCSAI on the sleep disturbances related to advanced PD. We provide an easy protocol to start this therapy.

Interpreting the concordance statistic of a logistic regression model: relation to the variance and odds ratio of a continuous explanatory variable

PubMed Central

2012-01-01

Background When outcomes are binary, the c-statistic (equivalent to the area under the Receiver Operating Characteristic curve) is a standard measure of the predictive accuracy of a logistic regression model. Methods An analytical expression was derived under the assumption that a continuous explanatory variable follows a normal distribution in those with and without the condition. We then conducted an extensive set of Monte Carlo simulations to examine whether the expressions derived under the assumption of binormality allowed for accurate prediction of the empirical c-statistic when the explanatory variable followed a normal distribution in the combined sample of those with and without the condition. We also examine the accuracy of the predicted c-statistic when the explanatory variable followed a gamma, log-normal or uniform distribution in combined sample of those with and without the condition. Results Under the assumption of binormality with equality of variances, the c-statistic follows a standard normal cumulative distribution function with dependence on the product of the standard deviation of the normal components (reflecting more heterogeneity) and the log-odds ratio (reflecting larger effects). Under the assumption of binormality with unequal variances, the c-statistic follows a standard normal cumulative distribution function with dependence on the standardized difference of the explanatory variable in those with and without the condition. In our Monte Carlo simulations, we found that these expressions allowed for reasonably accurate prediction of the empirical c-statistic when the distribution of the explanatory variable was normal, gamma, log-normal, and uniform in the entire sample of those with and without the condition. Conclusions The discriminative ability of a continuous explanatory variable cannot be judged by its odds ratio alone, but always needs to be considered in relation to the heterogeneity of the population. PMID:22716998

Interpreting the concordance statistic of a logistic regression model: relation to the variance and odds ratio of a continuous explanatory variable.

PubMed

Austin, Peter C; Steyerberg, Ewout W

2012-06-20

When outcomes are binary, the c-statistic (equivalent to the area under the Receiver Operating Characteristic curve) is a standard measure of the predictive accuracy of a logistic regression model. An analytical expression was derived under the assumption that a continuous explanatory variable follows a normal distribution in those with and without the condition. We then conducted an extensive set of Monte Carlo simulations to examine whether the expressions derived under the assumption of binormality allowed for accurate prediction of the empirical c-statistic when the explanatory variable followed a normal distribution in the combined sample of those with and without the condition. We also examine the accuracy of the predicted c-statistic when the explanatory variable followed a gamma, log-normal or uniform distribution in combined sample of those with and without the condition. Under the assumption of binormality with equality of variances, the c-statistic follows a standard normal cumulative distribution function with dependence on the product of the standard deviation of the normal components (reflecting more heterogeneity) and the log-odds ratio (reflecting larger effects). Under the assumption of binormality with unequal variances, the c-statistic follows a standard normal cumulative distribution function with dependence on the standardized difference of the explanatory variable in those with and without the condition. In our Monte Carlo simulations, we found that these expressions allowed for reasonably accurate prediction of the empirical c-statistic when the distribution of the explanatory variable was normal, gamma, log-normal, and uniform in the entire sample of those with and without the condition. The discriminative ability of a continuous explanatory variable cannot be judged by its odds ratio alone, but always needs to be considered in relation to the heterogeneity of the population.

A non-linear data mining parameter selection algorithm for continuous variables

PubMed Central

Razavi, Marianne; Brady, Sean

2017-01-01

In this article, we propose a new data mining algorithm, by which one can both capture the non-linearity in data and also find the best subset model. To produce an enhanced subset of the original variables, a preferred selection method should have the potential of adding a supplementary level of regression analysis that would capture complex relationships in the data via mathematical transformation of the predictors and exploration of synergistic effects of combined variables. The method that we present here has the potential to produce an optimal subset of variables, rendering the overall process of model selection more efficient. This algorithm introduces interpretable parameters by transforming the original inputs and also a faithful fit to the data. The core objective of this paper is to introduce a new estimation technique for the classical least square regression framework. This new automatic variable transformation and model selection method could offer an optimal and stable model that minimizes the mean square error and variability, while combining all possible subset selection methodology with the inclusion variable transformations and interactions. Moreover, this method controls multicollinearity, leading to an optimal set of explanatory variables. PMID:29131829

The pharmacotherapy of the HeartMate II, a continuous flow left ventricular assist device, in patients with advanced heart failure: integration of disease, device, and drug.

PubMed

Jennings, Douglas L; Chambers, Rachel M; Schillig, Jessica M

2010-10-01

Advanced heart failure continues to be a significant cause of morbidity and mortality in the US. Patients with advanced heart failure have a poor prognosis without cardiac transplantation. The use of left ventricular assist devices (LVADs) as destination therapy for these patients is therefore expected to increase in the coming years as technology advances. The HeartMate II, a continuous flow implantable device, is currently the only LVAD that has been approved by the Food and Drug Administration for destination therapy in patients with advanced heart failure. The pharmacotherapy associated with this device is very complex and, therefore, the need for expertly trained clinical pharmacists to care for this expanding patient population will also likely increase. Unfortunately, most pharmacists are unfamiliar with the effect of LVADs on the physiology and pharmacotherapy of a patient's heart failure. The purpose of this article is to give clinical pharmacists an introduction to the most common pharmacotherapeutic issues for patients with LVADs and present practical solutions for managing common drug therapy problems.

Randomized Controlled Trial of Family Therapy in Advanced Cancer Continued Into Bereavement.

PubMed

Kissane, David W; Zaider, Talia I; Li, Yuelin; Hichenberg, Shira; Schuler, Tammy; Lederberg, Marguerite; Lavelle, Lisa; Loeb, Rebecca; Del Gaudio, Francesca

2016-06-01

Systematic family-centered cancer care is needed. We conducted a randomized controlled trial of family therapy, delivered to families identified by screening to be at risk from dysfunctional relationships when one of their relatives has advanced cancer. Eligible patients with advanced cancer and their family members screened above the cut-off on the Family Relationships Index. After screening 1,488 patients or relatives at Memorial Sloan Kettering Cancer Center or three related community hospice programs, 620 patients (42%) were recruited, which represented 170 families. Families were stratified by three levels of family dysfunction (low communicating, low involvement, and high conflict) and randomly assigned to one of three arms: standard care or 6 or 10 sessions of a manualized family intervention. Primary outcomes were the Complicated Grief Inventory-Abbreviated (CGI) and Beck Depression Inventory-II (BDI-II). Generalized estimating equations allowed for clustered data in an intention-to-treat analysis. On the CGI, a significant treatment effect (Wald χ(2) = 6.88; df = 2; P = .032) and treatment by family-type interaction was found (Wald χ(2) = 20.64; df = 4; P < .001), and better outcomes resulted from 10 sessions compared with standard care for low-communicating and high-conflict groups compared with low-involvement families. Low-communicating families improved by 6 months of bereavement. In the standard care arm, 15.5% of the bereaved developed a prolonged grief disorder at 13 months of bereavement compared with 3.3% of those who received 10 sessions of intervention (Wald χ(2) = 8.31; df = 2; P =.048). No significant treatment effects were found on the BDI-II. Family-focused therapy delivered to high-risk families during palliative care and continued into bereavement reduced the severity of complicated grief and the development of prolonged grief disorder. © 2016 by American Society of Clinical Oncology.

Randomized Controlled Trial of Family Therapy in Advanced Cancer Continued Into Bereavement

PubMed Central

Zaider, Talia I.; Li, Yuelin; Hichenberg, Shira; Schuler, Tammy; Lederberg, Marguerite; Lavelle, Lisa; Loeb, Rebecca; Del Gaudio, Francesca

2016-01-01

Purpose Systematic family-centered cancer care is needed. We conducted a randomized controlled trial of family therapy, delivered to families identified by screening to be at risk from dysfunctional relationships when one of their relatives has advanced cancer. Patients and Methods Eligible patients with advanced cancer and their family members screened above the cut-off on the Family Relationships Index. After screening 1,488 patients or relatives at Memorial Sloan Kettering Cancer Center or three related community hospice programs, 620 patients (42%) were recruited, which represented 170 families. Families were stratified by three levels of family dysfunction (low communicating, low involvement, and high conflict) and randomly assigned to one of three arms: standard care or 6 or 10 sessions of a manualized family intervention. Primary outcomes were the Complicated Grief Inventory-Abbreviated (CGI) and Beck Depression Inventory-II (BDI-II). Generalized estimating equations allowed for clustered data in an intention-to-treat analysis. Results On the CGI, a significant treatment effect (Wald χ2 = 6.88; df = 2; P = .032) and treatment by family-type interaction was found (Wald χ2 = 20.64; df = 4; P < .001), and better outcomes resulted from 10 sessions compared with standard care for low-communicating and high-conflict groups compared with low-involvement families. Low-communicating families improved by 6 months of bereavement. In the standard care arm, 15.5% of the bereaved developed a prolonged grief disorder at 13 months of bereavement compared with 3.3% of those who received 10 sessions of intervention (Wald χ2 = 8.31; df = 2; P =.048). No significant treatment effects were found on the BDI-II. Conclusion Family-focused therapy delivered to high-risk families during palliative care and continued into bereavement reduced the severity of complicated grief and the development of prolonged grief disorder. PMID:27069071

Practical security analysis of continuous-variable quantum key distribution with jitter in clock synchronization

NASA Astrophysics Data System (ADS)

Xie, Cailang; Guo, Ying; Liao, Qin; Zhao, Wei; Huang, Duan; Zhang, Ling; Zeng, Guihua

2018-03-01

How to narrow the gap of security between theory and practice has been a notoriously urgent problem in quantum cryptography. Here, we analyze and provide experimental evidence of the clock jitter effect on the practical continuous-variable quantum key distribution (CV-QKD) system. The clock jitter is a random noise which exists permanently in the clock synchronization in the practical CV-QKD system, it may compromise the system security because of its impact on data sampling and parameters estimation. In particular, the practical security of CV-QKD with different clock jitter against collective attack is analyzed theoretically based on different repetition frequencies, the numerical simulations indicate that the clock jitter has more impact on a high-speed scenario. Furthermore, a simplified experiment is designed to investigate the influence of the clock jitter.

Continuous Variable Cluster State Generation over the Optical Spatial Mode Comb

DOE PAGES

Pooser, Raphael C.; Jing, Jietai

2014-10-20

One way quantum computing uses single qubit projective measurements performed on a cluster state (a highly entangled state of multiple qubits) in order to enact quantum gates. The model is promising due to its potential scalability; the cluster state may be produced at the beginning of the computation and operated on over time. Continuous variables (CV) offer another potential benefit in the form of deterministic entanglement generation. This determinism can lead to robust cluster states and scalable quantum computation. Recent demonstrations of CV cluster states have made great strides on the path to scalability utilizing either time or frequency multiplexingmore » in optical parametric oscillators (OPO) both above and below threshold. The techniques relied on a combination of entangling operators and beam splitter transformations. Here we show that an analogous transformation exists for amplifiers with Gaussian inputs states operating on multiple spatial modes. By judicious selection of local oscillators (LOs), the spatial mode distribution is analogous to the optical frequency comb consisting of axial modes in an OPO cavity. We outline an experimental system that generates cluster states across the spatial frequency comb which can also scale the amount of quantum noise reduction to potentially larger than in other systems.« less

Combination of continuous renal replacement therapies (CRRT) and extracorporeal membrane oxygenation (ECMO) for advanced cardiac patients.

PubMed

Yap, Hon-Jek; Chen, Yung-Chang; Fang, Ji-Tseng; Huang, Chiu-Ching

2003-03-01

The critically ill patients may require mechanical ventilation, cardiac mechanical support, and other types of critical support. Extracorporeal membrane oxygenation (ECMO) is a supportive therapy, which provides good cardiopulmonary and end-organ support. Continuous renal replacement therapies (CRRT) exhibit important advantages in terms of clinical tolerance and blood purification. This investigation aims to evaluate the acute renal failure in cardiac patients under ECMO, and assess the effect of combining these two technologies, ECMO and CRRT. Between December 1998 and June 2001, 10 adult cardiac patients were treated on ECMO. Five of them were treated with both ECMO and CRRT. The clinical outcomes were retrospectively analyzed. Of the 10 patients studied, five were men and five were women. The mean age of survivors and non-survivors was 37.00 +/- 14.54 years and 46.17 +/- 7.41 years, respectively. The overall mortality rate was 60%. Survivors did not differ significantly from non-survivors in age or gender. The APACHE II scores on the first day of ECMO support between survival and non-survival were 19.00 +/- 9.38 and 24.67 +/- 3.50 (P value = 0.392) (Table 2), which demonstrates no significant differences too. The cause of death in most patients was related to organ system failure during the 24 h immediately before ECMO started. Five patients with acute renal failure treated by CRRT were eventually died. The median and mean survival in this group on CRRT was 40.50 +/- 18.07 h and 92.60 +/- 60.50 h. We conclude that mortality rate for acute renal failure in cardiac patients under ECMO continues to be high. Our data suggest that acute renal failure is generally a part of multiorgan failure. This unique form of acute renal failure, causes generalized edema and fluid overload despite still low serum creatinine and azotemia, and deteriorates rapidly to death. From this study shows, advanced cardiac failure may need more aggressive and early initiation of ECMO support

Parameter Estimation with Almost No Public Communication for Continuous-Variable Quantum Key Distribution

NASA Astrophysics Data System (ADS)

Lupo, Cosmo; Ottaviani, Carlo; Papanastasiou, Panagiotis; Pirandola, Stefano

2018-06-01

One crucial step in any quantum key distribution (QKD) scheme is parameter estimation. In a typical QKD protocol the users have to sacrifice part of their raw data to estimate the parameters of the communication channel as, for example, the error rate. This introduces a trade-off between the secret key rate and the accuracy of parameter estimation in the finite-size regime. Here we show that continuous-variable QKD is not subject to this constraint as the whole raw keys can be used for both parameter estimation and secret key generation, without compromising the security. First, we show that this property holds for measurement-device-independent (MDI) protocols, as a consequence of the fact that in a MDI protocol the correlations between Alice and Bob are postselected by the measurement performed by an untrusted relay. This result is then extended beyond the MDI framework by exploiting the fact that MDI protocols can simulate device-dependent one-way QKD with arbitrarily high precision.

Simple proof that Gaussian attacks are optimal among collective attacks against continuous-variable quantum key distribution with a Gaussian modulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leverrier, Anthony; Grangier, Philippe; Laboratoire Charles Fabry, Institut d'Optique, CNRS, University Paris-Sud, Campus Polytechnique, RD 128, F-91127 Palaiseau Cedex

2010-06-15

In this article, we give a simple proof of the fact that the optimal collective attacks against continuous-variable quantum key distribution with a Gaussian modulation are Gaussian attacks. Our proof, which makes use of symmetry properties of the protocol in phase space, is particularly relevant for the finite-key analysis of the protocol and therefore for practical applications.

Exploratory Analysis of the Effects of Anxiety on Specific Quantifiable Variables of African-American High School Students Enrolled in Advanced Academics

ERIC Educational Resources Information Center

James, Carmela N.

2013-01-01

The purpose of this study was to examine the attrition rate of the African American high school student enrolled in advanced academics by looking at the effects of specific quantifiable variables on state-trait anxiety scores. More specifically, this study was concerned with the influence of demographic and school related factors on the…

Raw material variability of an active pharmaceutical ingredient and its relevance for processability in secondary continuous pharmaceutical manufacturing.

PubMed

Stauffer, F; Vanhoorne, V; Pilcer, G; Chavez, P-F; Rome, S; Schubert, M A; Aerts, L; De Beer, T

2018-06-01

Active Pharmaceutical Ingredients (API) raw material variability is not always thoroughly considered during pharmaceutical process development, mainly due to low quantities of drug substance available. However, synthesis, crystallization routes and production sites evolve during product development and product life cycle leading to changes in physical material attributes which can potentially affect their processability. Recent literature highlights the need for a global approach to understand the link between material synthesis, material variability, process and product quality. The study described in this article aims at explaining the raw material variability of an API using extensive material characterization on a restricted number of representative batches using multivariate data analysis. It is part of a larger investigation trying to link the API drug substance manufacturing process, the resulting physical API raw material attributes and the drug product continuous manufacturing process. Eight API batches produced using different synthetic routes, crystallization, drying, delumping processes and processing equipment were characterized, extensively. Seventeen properties from seven characterization techniques were retained for further analysis using Principal Component Analysis (PCA). Three principal components (PCs) were sufficient to explain 92.9% of the API raw material variability. The first PC was related to crystal length, agglomerate size and fraction, flowability and electrostatic charging. The second PC was driven by the span of the particle size distribution and the agglomerates strength. The third PC was related to surface energy. Additionally, the PCA allowed to summarize the API batch-to-batch variability in only three PCs which can be used in future drug product development studies to quantitatively evaluate the impact of the API raw material variability upon the drug product process. The approach described in this article could be applied to any

A direct-execution parallel architecture for the Advanced Continuous Simulation Language (ACSL)

NASA Technical Reports Server (NTRS)

Carroll, Chester C.; Owen, Jeffrey E.

1988-01-01

A direct-execution parallel architecture for the Advanced Continuous Simulation Language (ACSL) is presented which overcomes the traditional disadvantages of simulations executed on a digital computer. The incorporation of parallel processing allows the mapping of simulations into a digital computer to be done in the same inherently parallel manner as they are currently mapped onto an analog computer. The direct-execution format maximizes the efficiency of the executed code since the need for a high level language compiler is eliminated. Resolution is greatly increased over that which is available with an analog computer without the sacrifice in execution speed normally expected with digitial computer simulations. Although this report covers all aspects of the new architecture, key emphasis is placed on the processing element configuration and the microprogramming of the ACLS constructs. The execution times for all ACLS constructs are computed using a model of a processing element based on the AMD 29000 CPU and the AMD 29027 FPU. The increase in execution speed provided by parallel processing is exemplified by comparing the derived execution times of two ACSL programs with the execution times for the same programs executed on a similar sequential architecture.

Recovery of resources for advanced life support space applications: effect of retention time on biodegradation of two crop residues in a fed-batch, continuous stirred tank reactor.

PubMed

Strayer, R F; Finger, B W; Alazraki, M P; Cook, K; Garland, J L

2002-09-01

Bioreactor retention time is a key process variable that will influence costs that are relevant to long distance space travel or long duration space habitation. However. little is known about the effects of this parameter on the microbiological treatment options that are being proposed for Advanced Life Support (ALS) systems. Two bioreactor studies were designed to examine this variable. In the first one, six retention times ranging from 1.3 to 21.3 days--were run in duplicate, 81 working-volume continuous stirred tank reactors (CSTR) that were fed ALS wheat residues. Ash-free dry weight loss, carbon mineralization, soluble TOC reduction, changes in fiber content (cellulose, hemicellulose, and lignin), bacterial numbers, and mineral recoveries were monitored. At short retention times--1.33 days--biodegradation was poor (total: 16-20%, cellulose - 12%, hemicellulose - 28%) but soluble TOC was decreased by 75-80% and recovery of major crop inorganic nutrients was adequate, except for phosphorus. A high proportion of the total bacteria (ca. 83%) was actively respiring. At the longest retention time tested, 21.3 days, biodegradation was good (total: 55-60%, cellulose ca. 70%, hemicellulose - ca. 55%) and soluble TOC was decreased by 80%. Recovery of major nutrients, except phosphorus, remained adequate. A very low proportion of total bacteria was actively respiring (ca. 16%). The second bioreactor study used potato residue to determine if even shorter retention times could be used (range 0.25-2.0 days). Although overall biodegradation deteriorated, the degradation of soluble TOC continued to be ca. 75%. We conclude that if the goal of ALS bioprocessing is maximal degradation of crop residues, including cellulose, then retention times of 10 days or longer will be needed. If the goal is to provide inorganic nutrients with the smallest volume/weight bioreactor possible, then a retention time of 1 day (or less) is sufficient.

Recovery of resources for advanced life support space applications: effect of retention time on biodegradation of two crop residues in a fed-batch, continuous stirred tank reactor

NASA Technical Reports Server (NTRS)

Strayer, R. F.; Finger, B. W.; Alazraki, M. P.; Cook, K.; Garland, J. L.

2002-01-01

Bioreactor retention time is a key process variable that will influence costs that are relevant to long distance space travel or long duration space habitation. However. little is known about the effects of this parameter on the microbiological treatment options that are being proposed for Advanced Life Support (ALS) systems. Two bioreactor studies were designed to examine this variable. In the first one, six retention times ranging from 1.3 to 21.3 days--were run in duplicate, 81 working-volume continuous stirred tank reactors (CSTR) that were fed ALS wheat residues. Ash-free dry weight loss, carbon mineralization, soluble TOC reduction, changes in fiber content (cellulose, hemicellulose, and lignin), bacterial numbers, and mineral recoveries were monitored. At short retention times--1.33 days--biodegradation was poor (total: 16-20%, cellulose - 12%, hemicellulose - 28%) but soluble TOC was decreased by 75-80% and recovery of major crop inorganic nutrients was adequate, except for phosphorus. A high proportion of the total bacteria (ca. 83%) was actively respiring. At the longest retention time tested, 21.3 days, biodegradation was good (total: 55-60%, cellulose ca. 70%, hemicellulose - ca. 55%) and soluble TOC was decreased by 80%. Recovery of major nutrients, except phosphorus, remained adequate. A very low proportion of total bacteria was actively respiring (ca. 16%). The second bioreactor study used potato residue to determine if even shorter retention times could be used (range 0.25-2.0 days). Although overall biodegradation deteriorated, the degradation of soluble TOC continued to be ca. 75%. We conclude that if the goal of ALS bioprocessing is maximal degradation of crop residues, including cellulose, then retention times of 10 days or longer will be needed. If the goal is to provide inorganic nutrients with the smallest volume/weight bioreactor possible, then a retention time of 1 day (or less) is sufficient.

Pilot-multiplexed continuous-variable quantum key distribution with a real local oscillator

NASA Astrophysics Data System (ADS)

Wang, Tao; Huang, Peng; Zhou, Yingming; Liu, Weiqi; Zeng, Guihua

2018-01-01

We propose a pilot-multiplexed continuous-variable quantum key distribution (CVQKD) scheme based on a local local oscillator (LLO). Our scheme utilizes time-multiplexing and polarization-multiplexing techniques to dramatically isolate the quantum signal from the pilot, employs two heterodyne detectors to separately detect the signal and the pilot, and adopts a phase compensation method to almost eliminate the multifrequency phase jitter. In order to analyze the performance of our scheme, a general LLO noise model is constructed. Besides the phase noise and the modulation noise, the photon-leakage noise from the reference path and the quantization noise due to the analog-to-digital converter (ADC) are also considered, which are first analyzed in the LLO regime. Under such general noise model, our scheme has a higher key rate and longer secure distance compared with the preexisting LLO schemes. Moreover, we also conduct an experiment to verify our pilot-multiplexed scheme. Results show that it maintains a low level of the phase noise and is expected to obtain a 554-Kbps secure key rate within a 15-km distance under the finite-size effect.

Continuous-variable Measurement-device-independent Quantum Relay Network with Phase-sensitive Amplifiers

NASA Astrophysics Data System (ADS)

Li, Fei; Zhao, Wei; Guo, Ying

2018-01-01

Continuous-variable (CV) measurement-device-independent (MDI) quantum cryptography is now heading towards solving the practical problem of implementing scalable quantum networks. In this paper, we show that a solution can come from deploying an optical amplifier in the CV-MDI system, aiming to establish a high-rate quantum network. We suggest an improved CV-MDI protocol using the EPR states coupled with optical amplifiers. It can implement a practical quantum network scheme, where the legal participants create the secret correlations by using EPR states connecting to an untrusted relay via insecure links and applying the multi-entangled Greenberger-Horne-Zeilinger (GHZ) state analysis at relay station. Despite the possibility that the relay could be completely tampered with and imperfect links are subject to the powerful attacks, the legal participants are still able to extract a secret key from network communication. The numerical simulation indicates that the quantum network communication can be achieved in an asymmetric scenario, fulfilling the demands of a practical quantum network. Furthermore, we show that the use of optical amplifiers can compensate the inherent imperfections and improve the secret key rate of the CV-MDI system.

Evaluation Models for Continuing Education Program Efficacy: How Does Athletic Training Continuing Education Measure up?

ERIC Educational Resources Information Center

Doherty-Restrepo, Jennifer L.; Hughes, Brian J.; Del Rossi, Gianluca; Pitney, William A.

2009-01-01

Objective: Although continuing education is required for athletic trainers (AT) to maintain their Board of Certification credential, little is known regarding its efficacy for advancing knowledge and improving patient care. Continuing professional education (CPE) is designed to provide professionals with important practical learning opportunities.…

Quantum hacking: Saturation attack on practical continuous-variable quantum key distribution

NASA Astrophysics Data System (ADS)

Qin, Hao; Kumar, Rupesh; Alléaume, Romain

2016-07-01

We identify and study a security loophole in continuous-variable quantum key distribution (CVQKD) implementations, related to the imperfect linearity of the homodyne detector. By exploiting this loophole, we propose an active side-channel attack on the Gaussian-modulated coherent-state CVQKD protocol combining an intercept-resend attack with an induced saturation of the homodyne detection on the receiver side (Bob). We show that an attacker can bias the excess noise estimation by displacing the quadratures of the coherent states received by Bob. We propose a saturation model that matches experimental measurements on the homodyne detection and use this model to study the impact of the saturation attack on parameter estimation in CVQKD. We demonstrate that this attack can bias the excess noise estimation beyond the null key threshold for any system parameter, thus leading to a full security break. If we consider an additional criterion imposing that the channel transmission estimation should not be affected by the attack, then the saturation attack can only be launched if the attenuation on the quantum channel is sufficient, corresponding to attenuations larger than approximately 6 dB. We moreover discuss the possible countermeasures against the saturation attack and propose a countermeasure based on Gaussian postselection that can be implemented by classical postprocessing and may allow one to distill the secret key when the raw measurement data are partly saturated.

Technological Advances In The Surgical Treatment Of Movement Disorders

PubMed Central

Gross, Robert E.; McDougal, Margaret E.

2013-01-01

Technological innovations have driven the advancement of the surgical treatment of movement disorders, from the invention of the stereotactic frame to the adaptation of deep brain stimulation (DBS). Along these lines, this review will describe recent advances in getting neuromodulation modalities, including DBS, to the target; and in the delivery of therapy at the target. Recent radiological advances are altering the way that DBS leads are targeted and inserted, by refining the ability to visualize the subcortical targets using high-field strength MRI and other innovations such as diffusion tensor imaging, and the development of novel targeting devices enabling purely anatomical implantations without the need for neurophysiological monitoring. New portable CT scanners also are facilitating lead implantation without monitoring as well as improving radiological verification of DBS lead location. Advances in neurophysiological mapping include efforts to develop automatic target verification algorithms, and probabilistic maps to guide target selection. The delivery of therapy at the target is being improved by the development of the next generation of internal pulse generators (IPGs). These include constant current devices that mitigate the variability introduced by impedance changes of the stimulated tissue, and in the near future, devices that deliver novel stimulation patterns with improved efficiency. Closed-loop adaptive IPGs are being tested, which may tailor stimulation to ongoing changes in the nervous system reflected in Œbiomarkers1 continuously recorded by the devices. Finer grained DBS leads, in conjunction with new IPGs and advanced programming tools, may offer improved outcomes via Œcurrent steering1 algorithms. Finally, even thermocoagulation - essentially replaced by DBS - is being advanced by new Œminimally-invasive1 approaches that may improve this therapy for selected patients in whom it may be preferred. Functional neurosurgery has a history of

Technological advances in the surgical treatment of movement disorders.

PubMed

Gross, Robert E; McDougal, Margaret E

2013-08-01

Technological innovations have driven the advancement of the surgical treatment of movement disorders, from the invention of the stereotactic frame to the adaptation of deep brain stimulation (DBS). Along these lines, this review will describe recent advances in inserting neuromodulation modalities, including DBS, to the target, and in the delivery of therapy at the target. Recent radiological advances are altering the way that DBS leads are targeted and inserted, by refining the ability to visualize the subcortical targets using high-field strength magnetic resonance imaging and other innovations, such as diffusion tensor imaging, and the development of novel targeting devices enabling purely anatomical implantations without the need for neurophysiological monitoring. New portable computed tomography scanners also are facilitating lead implantation without monitoring, as well as improving radiological verification of DBS lead location. Advances in neurophysiological mapping include efforts to develop automatic target verification algorithms, and probabilistic maps to guide target selection. The delivery of therapy at the target is being improved by the development of the next generation of internal pulse generators (IPGs). These include constant current devices that mitigate the variability introduced by impedance changes of the stimulated tissue and, in the near future, devices that deliver novel stimulation patterns with improved efficiency. Closed-loop adaptive IPGs are being tested, which may tailor stimulation to ongoing changes in the nervous system, reflected in biomarkers continuously recorded by the devices. Finer-grained DBS leads, in conjunction with new IPGs and advanced programming tools, may offer improved outcomes via current steering algorithms. Finally, even thermocoagulation-essentially replaced by DBS-is being advanced by new minimally-invasive approaches that may improve this therapy for selected patients in whom it may be preferred. Functional

Advancing nursing practice: redefining the theoretical and practical integration of knowledge.

PubMed

Christensen, Martin

2011-03-01

The aim of this paper is to offer an alternative knowing-how knowing-that framework of nursing knowledge, which in the past has been accepted as the provenance of advanced practice. The concept of advancing practice is central to the development of nursing practice and has been seen to take on many different forms depending on its use in context. To many it has become synonymous with the work of the advanced or expert practitioner; others have viewed it as a process of continuing professional development and skills acquisition. Moreover, it is becoming closely linked with practice development. However, there is much discussion as to what constitutes the knowledge necessary for advancing and advanced practice, and it has been suggested that theoretical and practical knowledge form the cornerstone of advanced knowledge. The design of this article takes a discursive approach as to the meaning and integration of knowledge within the context of advancing nursing practice. A thematic analysis of the current discourse relating to knowledge integration models in an advancing and advanced practice arena was used to identify concurrent themes relating to the knowing-how knowing-that framework which commonly used to classify the knowledge necessary for advanced nursing practice. There is a dichotomy as to what constitutes knowledge for advanced and advancing practice. Several authors have offered a variety of differing models, yet it is the application and integration of theoretical and practical knowledge that defines and develops the advancement of nursing practice. An alternative framework offered here may allow differences in the way that nursing knowledge important for advancing practice is perceived, developed and coordinated. What has inevitably been neglected is that there are various other variables which when transposed into the existing knowing-how knowing-that framework allows for advanced knowledge to be better defined. One of the more notable variables is

A Simulation Study of Categorizing Continuous Exposure Variables Measured with Error in Autism Research: Small Changes with Large Effects.

PubMed

Heavner, Karyn; Burstyn, Igor

2015-08-24

Variation in the odds ratio (OR) resulting from selection of cutoffs for categorizing continuous variables is rarely discussed. We present results for the effect of varying cutoffs used to categorize a mismeasured exposure in a simulated population in the context of autism spectrum disorders research. Simulated cohorts were created with three distinct exposure-outcome curves and three measurement error variances for the exposure. ORs were calculated using logistic regression for 61 cutoffs (mean ± 3 standard deviations) used to dichotomize the observed exposure. ORs were calculated for five categories with a wide range for the cutoffs. For each scenario and cutoff, the OR, sensitivity, and specificity were calculated. The three exposure-outcome relationships had distinctly shaped OR (versus cutoff) curves, but increasing measurement error obscured the shape. At extreme cutoffs, there was non-monotonic oscillation in the ORs that cannot be attributed to "small numbers." Exposure misclassification following categorization of the mismeasured exposure was differential, as predicted by theory. Sensitivity was higher among cases and specificity among controls. Cutoffs chosen for categorizing continuous variables can have profound effects on study results. When measurement error is not too great, the shape of the OR curve may provide insight into the true shape of the exposure-disease relationship.

Systems, methods, and software for determining spatially variable distributions of the dielectric properties of a heterogeneous material

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farrington, Stephen P.

Systems, methods, and software for measuring the spatially variable relative dielectric permittivity of materials along a linear or otherwise configured sensor element, and more specifically the spatial variability of soil moisture in one dimension as inferred from the dielectric profile of the soil matrix surrounding a linear sensor element. Various methods provided herein combine advances in the processing of time domain reflectometry data with innovations in physical sensing apparatuses. These advancements enable high temporal (and thus spatial) resolution of electrical reflectance continuously along an insulated waveguide that is permanently emplaced in contact with adjacent soils. The spatially resolved reflectance ismore » directly related to impedance changes along the waveguide that are dominated by electrical permittivity contrast due to variations in soil moisture. Various methods described herein are thus able to monitor soil moisture in profile with high spatial resolution.« less

Globular Cluster Variable Stars—Atlas and Coordinate Improvement using AAVSOnet Telescopes (Abstract)

NASA Astrophysics Data System (ADS)

Welch, D.; Henden, A.; Bell, T.; Suen, C.; Fare, I.; Sills, A.

2015-12-01

(Abstract only) The variable stars of globular clusters have played and continue to play a significant role in our understanding of certain classes of variable stars. Since all stars associated with a cluster have the same age, metallicity, distance and usually very similar (if not identical reddenings), such variables can produce uniquely powerful constraints on where certain types of pulsation behaviors are excited. Advanced amateur astronomers are increasingly well-positioned to provide long-term CCD monitoring of globular cluster variable star but are hampered by a long history of poor or inaccessible finder charts and coordinates. Many of variable-rich clusters have published photographic finder charts taken in relatively poor seeing with blue-sensitive photographic plates. While useful signal-to-noise ratios are relatively straightforward to achieve for RR Lyrae, Type 2 Cepheids, and red giant variables, correct identification remains a difficult issue—particularly when images are taken at V or longer wavelengths. We describe the project and report its progress using the OC61, TMO61, and SRO telescopes of AAVSOnet after the first year of image acquisition and demonstrate several of the data products being developed for globular cluster variables.

Practical performance of real-time shot-noise measurement in continuous-variable quantum key distribution

NASA Astrophysics Data System (ADS)

Wang, Tao; Huang, Peng; Zhou, Yingming; Liu, Weiqi; Zeng, Guihua

2018-01-01

In a practical continuous-variable quantum key distribution (CVQKD) system, real-time shot-noise measurement (RTSNM) is an essential procedure for preventing the eavesdropper exploiting the practical security loopholes. However, the performance of this procedure itself is not analyzed under the real-world condition. Therefore, we indicate the RTSNM practical performance and investigate its effects on the CVQKD system. In particular, due to the finite-size effect, the shot-noise measurement at the receiver's side may decrease the precision of parameter estimation and consequently result in a tight security bound. To mitigate that, we optimize the block size for RTSNM under the ensemble size limitation to maximize the secure key rate. Moreover, the effect of finite dynamics of amplitude modulator in this scheme is studied and its mitigation method is also proposed. Our work indicates the practical performance of RTSNM and provides the real secret key rate under it.

Temporal variability of tidal and gravity waves during a record long 10-day continuous lidar sounding

NASA Astrophysics Data System (ADS)

Baumgarten, Kathrin; Gerding, Michael; Baumgarten, Gerd; Lübken, Franz-Josef

2018-01-01

Gravity waves (GWs) as well as solar tides are a key driving mechanism for the circulation in the Earth's atmosphere. The propagation of gravity waves is strongly affected by tidal waves as they modulate the mean background wind field and vice versa, which is not yet fully understood and not adequately implemented in many circulation models. The daylight-capable Rayleigh-Mie-Raman (RMR) lidar at Kühlungsborn (54° N, 12° E) typically provides temperature data to investigate both wave phenomena during one full day or several consecutive days in the middle atmosphere between 30 and 75 km altitude. Outstanding weather conditions in May 2016 allowed for an unprecedented 10-day continuous lidar measurement, which shows a large variability of gravity waves and tides on timescales of days. Using a one-dimensional spectral filtering technique, gravity and tidal waves are separated according to their specific periods or vertical wavelengths, and their temporal evolution is studied. During the measurement period a strong 24 h wave occurs only between 40 and 60 km and vanishes after a few days. The disappearance is related to an enhancement of gravity waves with periods of 4-8 h. Wind data provided by ECMWF are used to analyze the meteorological situation at our site. The local wind structure changes during the observation period, which leads to different propagation conditions for gravity waves in the last days of the measurement period and therefore a strong GW activity. The analysis indicates a further change in wave-wave interaction resulting in a minimum of the 24 h tide. The observed variability of tides and gravity waves on timescales of a few days clearly demonstrates the importance of continuous measurements with high temporal and spatial resolution to detect interaction phenomena, which can help to improve parametrization schemes of GWs in general circulation models.

Long-distance continuous-variable quantum key distribution using non-Gaussian state-discrimination detection

NASA Astrophysics Data System (ADS)

Liao, Qin; Guo, Ying; Huang, Duan; Huang, Peng; Zeng, Guihua

2018-02-01

We propose a long-distance continuous-variable quantum key distribution (CVQKD) with a four-state protocol using non-Gaussian state-discrimination detection. A photon subtraction operation, which is deployed at the transmitter, is used for splitting the signal required for generating the non-Gaussian operation to lengthen the maximum transmission distance of the CVQKD. Whereby an improved state-discrimination detector, which can be deemed as an optimized quantum measurement that allows the discrimination of nonorthogonal coherent states beating the standard quantum limit, is applied at the receiver to codetermine the measurement result with the conventional coherent detector. By tactfully exploiting the multiplexing technique, the resulting signals can be simultaneously transmitted through an untrusted quantum channel, and subsequently sent to the state-discrimination detector and coherent detector, respectively. Security analysis shows that the proposed scheme can lengthen the maximum transmission distance up to hundreds of kilometers. Furthermore, by taking the finite-size effect and composable security into account we obtain the tightest bound of the secure distance, which is more practical than that obtained in the asymptotic limit.

A Polychoric Instrumental Variable (PIV) Estimator for Structural Equation Models with Categorical Variables

ERIC Educational Resources Information Center

Bollen, Kenneth A.; Maydeu-Olivares, Albert

2007-01-01

This paper presents a new polychoric instrumental variable (PIV) estimator to use in structural equation models (SEMs) with categorical observed variables. The PIV estimator is a generalization of Bollen's (Psychometrika 61:109-121, 1996) 2SLS/IV estimator for continuous variables to categorical endogenous variables. We derive the PIV estimator…

Continuous subcutaneous apomorphine infusion in advanced Parkinson's disease: 10-year experience with 230 patients.

PubMed

Sesar, Ángel; Fernández-Pajarín, Gustavo; Ares, Begoña; Rivas, María Teresa; Castro, Alfonso

2017-05-01

Continuous apomorphine infusion (APO) is one of the treatments available for advanced Parkinson disease (PD). Over 10 years, we have treated 230 patients with APO. Mean age was 66.8 and average evolution time at APO onset was 13.0 years. Mean duration of the treatment was 26.3 months. As of June 2016, 93 remained on the medication (active group), while 137 had stopped. This active group had mean age 67.3 at recruitment and mean evolution 14.2 years. The main indication for APO was lack of deep brain stimulation criteria (DBS). Twelve patients were on waiting list for DBS. Average time since APO onset was 40.0 months. In the active group, APO decreased off-state in 4 h and allowed reducing levodopa and dopamine agonists. Dyskinesia and balance did not worsen. Cognitive decline did not change within the first 15 months. Hallucinations were the same within the first 39 months. The presence of subcutaneous nodules was the most frequent adverse event in this group. The main reason for discontinuation was side effects, being psychosis the most common. Within the first year, 82 patients stopped APO. Eighteen of these patients eventually got DBS. APO is a good option for advanced PD, since it permits a significant reduction in off-time and other antiparkinsonian drugs. This effect is sustained over time. We have treated 132 patients for over a year. Dyskinesia seems not to worsen. Combining APO with DBS simultaneously or alternatively provides good results.

Intelligent Control Electromagnetic Actuated Continuously Variable Transmission System for Passenger Car

NASA Astrophysics Data System (ADS)

Rahman, Ataur; Sharif, Sazzad; Mohiuddin, AKM; Faris Ismail, Ahmed; Izan, Sany Ihsan

2017-03-01

Continuously variable transmission (CVT) system transmits the engine /battery power to the car driving wheel smoothly and efficiently. Cars with CVT produces some noise and slow acceleration to meet the car power demand on initial start-ups and slow speed. The car noise is produced as a result of CVT adjustment the engine speed with the hydraulic pressure. The current CVT problems incurred due to the slow response of hydraulic pressure and CVT fluid viscosity due to the development of heat.The aim of this study is to develop electromagnetic actuated CVT (EMA-CVT) with intelligent switching controlling system (ICS). The experimental results of ¼ scale EMA shows that it make the acceleration time of the car in 3.5-5 sec which is 40% less than the hydraulic CVT in the market. The EMA develops the electromagnetic force in the ranged of 350 -1200 N for the supply current in the range of 10-15 amp. This study introduced fuzzy intelligent system (FIS) to predict the EMA system dynamic behaviour in order to identify the current control for the EMA actuation during operation of the CVT. It is expecting that the up scale EMA-CVT would reduce the 75% of vehicle power transmission loss by accelerating vehicle in 5 sec and save the IC engine power consumption about 20% which will makes the vehicle energy efficient (EEV) and reduction of green house gas reduction.

Improving Continuous-Variable Measurement-Device-Independent Multipartite Quantum Communication with Optical Amplifiers*

NASA Astrophysics Data System (ADS)

Guo, Ying; Zhao, Wei; Li, Fei; Huang, Duan; Liao, Qin; Xie, Cai-Lang

2017-08-01

The developing tendency of continuous-variable (CV) measurement-device-independent (MDI) quantum cryptography is to cope with the practical issue of implementing scalable quantum networks. Up to now, most theoretical and experimental researches on CV-MDI QKD are focused on two-party protocols. However, we suggest a CV-MDI multipartite quantum secret sharing (QSS) protocol use the EPR states coupled with optical amplifiers. More remarkable, QSS is the real application in multipartite CV-MDI QKD, in other words, is the concrete implementation method of multipartite CV-MDI QKD. It can implement a practical quantum network scheme, under which the legal participants create the secret correlations by using EPR states connecting to an untrusted relay via insecure links and applying the multi-entangled Greenberger-Horne-Zeilinger (GHZ) state analysis at relay station. Even if there is a possibility that the relay may be completely tampered, the legal participants are still able to extract a secret key from network communication. The numerical simulation indicates that the quantum network communication can be achieved in an asymmetric scenario, fulfilling the demands of a practical quantum network. Additionally, we illustrate that the use of optical amplifiers can compensate the partial inherent imperfections of detectors and increase the transmission distance of the CV-MDI quantum system.

Real-time Continuous Assessment Method for Mental and Physiological Condition using Heart Rate Variability

NASA Astrophysics Data System (ADS)

Yoshida, Yutaka; Yokoyama, Kiyoko; Ishii, Naohiro

It is necessary to monitor the daily health condition for preventing stress syndrome. In this study, it was proposed the method assessing the mental and physiological condition, such as the work stress or the relaxation, using heart rate variability at real time and continuously. The instantanuous heart rate (HR), and the ratio of the number of extreme points (NEP) and the number of heart beats were calculated for assessing mental and physiological condition. In this method, 20 beats heart rate were used to calculate these indexes. These were calculated in one beat interval. Three conditions, which are sitting rest, performing mental arithmetic and watching relaxation movie, were assessed using our proposed algorithm. The assessment accuracies were 71.9% and 55.8%, when performing mental arithmetic and watching relaxation movie respectively. In this method, the mental and physiological condition was assessed using only 20 regressive heart beats, so this method is considered as the real time assessment method.

Performance improvement of eight-state continuous-variable quantum key distribution with an optical amplifier

NASA Astrophysics Data System (ADS)

Guo, Ying; Li, Renjie; Liao, Qin; Zhou, Jian; Huang, Duan

2018-02-01

Discrete modulation is proven to be beneficial to improving the performance of continuous-variable quantum key distribution (CVQKD) in long-distance transmission. In this paper, we suggest a construct to improve the maximal generated secret key rate of discretely modulated eight-state CVQKD using an optical amplifier (OA) with a slight cost of transmission distance. In the proposed scheme, an optical amplifier is exploited to compensate imperfection of Bob's apparatus, so that the generated secret key rate of eight-state protocol is enhanced. Specifically, we investigate two types of optical amplifiers, phase-insensitive amplifier (PIA) and phase-sensitive amplifier (PSA), and thereby obtain approximately equivalent improved performance for eight-state CVQKD system when applying these two different amplifiers. Numeric simulation shows that the proposed scheme can well improve the generated secret key rate of eight-state CVQKD in both asymptotic limit and finite-size regime. We also show that the proposed scheme can achieve the relatively high-rate transmission at long-distance communication system.

Continuous-variable geometric phase and its manipulation for quantum computation in a superconducting circuit.

PubMed

Song, Chao; Zheng, Shi-Biao; Zhang, Pengfei; Xu, Kai; Zhang, Libo; Guo, Qiujiang; Liu, Wuxin; Xu, Da; Deng, Hui; Huang, Keqiang; Zheng, Dongning; Zhu, Xiaobo; Wang, H

2017-10-20

Geometric phase, associated with holonomy transformation in quantum state space, is an important quantum-mechanical effect. Besides fundamental interest, this effect has practical applications, among which geometric quantum computation is a paradigm, where quantum logic operations are realized through geometric phase manipulation that has some intrinsic noise-resilient advantages and may enable simplified implementation of multi-qubit gates compared to the dynamical approach. Here we report observation of a continuous-variable geometric phase and demonstrate a quantum gate protocol based on this phase in a superconducting circuit, where five qubits are controllably coupled to a resonator. Our geometric approach allows for one-step implementation of n-qubit controlled-phase gates, which represents a remarkable advantage compared to gate decomposition methods, where the number of required steps dramatically increases with n. Following this approach, we realize these gates with n up to 4, verifying the high efficiency of this geometric manipulation for quantum computation.

Translating glucose variability metrics into the clinic via Continuous Glucose Monitoring: a Graphical User Interface for Diabetes Evaluation (CGM-GUIDE©).

PubMed

Rawlings, Renata A; Shi, Hang; Yuan, Lo-Hua; Brehm, William; Pop-Busui, Rodica; Nelson, Patrick W

2011-12-01

Several metrics of glucose variability have been proposed to date, but an integrated approach that provides a complete and consistent assessment of glycemic variation is missing. As a consequence, and because of the tedious coding necessary during quantification, most investigators and clinicians have not yet adopted the use of multiple glucose variability metrics to evaluate glycemic variation. We compiled the most extensively used statistical techniques and glucose variability metrics, with adjustable hyper- and hypoglycemic limits and metric parameters, to create a user-friendly Continuous Glucose Monitoring Graphical User Interface for Diabetes Evaluation (CGM-GUIDE©). In addition, we introduce and demonstrate a novel transition density profile that emphasizes the dynamics of transitions between defined glucose states. Our combined dashboard of numerical statistics and graphical plots support the task of providing an integrated approach to describing glycemic variability. We integrated existing metrics, such as SD, area under the curve, and mean amplitude of glycemic excursion, with novel metrics such as the slopes across critical transitions and the transition density profile to assess the severity and frequency of glucose transitions per day as they move between critical glycemic zones. By presenting the above-mentioned metrics and graphics in a concise aggregate format, CGM-GUIDE provides an easy to use tool to compare quantitative measures of glucose variability. This tool can be used by researchers and clinicians to develop new algorithms of insulin delivery for patients with diabetes and to better explore the link between glucose variability and chronic diabetes complications.

Between-Subject Variability in the Breaking Continuous Flash Suppression Paradigm: Potential Causes, Consequences, and Solutions

PubMed Central

Gayet, Surya; Stein, Timo

2017-01-01

A recent focus in the field of consciousness research involves investigating the propensity of initially non-conscious visual information to gain access to consciousness. A critical tool for measuring conscious access is the so-called breaking continuous flash suppression paradigm (b-CFS). In this paradigm, a high contrast dynamic pattern is presented to one eye, thereby temporarily suppressing a target stimulus that is presented to the other eye. The time it takes for observers to report (e.g., the location of) the initially suppressed stimulus provides a measure of conscious access. Typical observations in b-CFS studies include the finding that upright faces are released from suppression faster than inverted faces, and the finding that stimuli that match the current content of visual working memory are released from suppression faster than mismatching stimuli. Interestingly, the extent to which observers exhibit these effects varies extensively (in the range of hundreds of milliseconds). By re-analyzing existing datasets and a new dataset we establish that the difference in RTs between conditions in b-CFS tasks (i.e., the effect of interest) is highly correlated with participants' overall suppression durations, and with their trial-to-trial variability in RTs. We advocate the usage of a simple latency- normalization method, which (1) removes the between-subject variability in suppression duration from the effect of interest, while (2) providing distributions of RT differences that are better suited for parametric testing. We next compare this latency-normalization method to two other transformations that are widely applied on within-subject RT data (z-transformations and log-transformations). Finally, we tentatively discuss how trial-to-trial variability and overall suppression duration might relate to prolonged phases of shallow suppression that are more prone to modulations of conscious access. PMID:28396645

Virtual continuity of measurable functions and its applications

NASA Astrophysics Data System (ADS)

Vershik, A. M.; Zatitskii, P. B.; Petrov, F. V.

2014-12-01

A classical theorem of Luzin states that a measurable function of one real variable is `almost' continuous. For measurable functions of several variables the analogous statement (continuity on a product of sets having almost full measure) does not hold in general. The search for a correct analogue of Luzin's theorem leads to a notion of virtually continuous functions of several variables. This apparently new notion implicitly appears in the statements of embedding theorems and trace theorems for Sobolev spaces. In fact it reveals the nature of such theorems as statements about virtual continuity. The authors' results imply that under the conditions of Sobolev theorems there is a well-defined integration of a function with respect to a wide class of singular measures, including measures concentrated on submanifolds. The notion of virtual continuity is also used for the classification of measurable functions of several variables and in some questions on dynamical systems, the theory of polymorphisms, and bistochastic measures. In this paper the necessary definitions and properties of admissible metrics are recalled, several definitions of virtual continuity are given, and some applications are discussed. Bibliography: 24 titles.

Mean Levels and Variability in Affect, Diabetes Self-Care Behaviors, and Continuously Monitored Glucose: A Daily Study of Latinos With Type 2 Diabetes.

PubMed

Wagner, Julie; Armeli, Stephen; Tennen, Howard; Bermudez-Millan, Angela; Wolpert, Howard; Pérez-Escamilla, Rafael

2017-09-01

This study investigated between- and within-person associations among mean levels and variability in affect, diabetes self-care behaviors, and continuously monitored glucose in Latinos with type 2 diabetes. Fifty participants (M [SD] age = 57.8 [11.7] years, 74% women, mean [SD] glycosylated hemoglobin A1c = 8.3% [1.5%]) wore a "blinded" continuous glucose monitor for 7 days, and they responded to twice daily automated phone surveys regarding positive affect, negative affect, and self-care behaviors. Higher mean levels of NA were associated with higher mean glucose (r = .30), greater percent hyperglycemia (r = .34) and greater percentage of out-of-range glucose (r = .34). Higher NA variability was also related to higher mean glucose (r = .34), greater percent of hyperglycemia (r = .44) and greater percentage of out-of-range glucose (r = .43). Higher positive affect variability was related to lower percentage of hypoglycemia (r = -.33). Higher mean levels of self-care behaviors were related to lower glucose variability (r = -.35). Finally, higher self-care behavior variability was related to greater percentage of hyperglycemia (r = .31) and greater percentage of out-of-range glucose (r = -.28). In multilevel regression models, within-person increases from mean levels of self-care were associated with lower mean levels of glucose (b = -7.4, 95% confidence interval [CI] = -12.8 to -1.9), lower percentage of hyperglycemia (b = -0.04, 95% CI = -0.07 to -0.01), and higher percentage of hypoglycemia (b = 0.02, 95% CI = 0.01 to 0.03) in the subsequent 10-hour period. Near-to-real time sampling documented associations of glucose with affect and diabetes self-care that are not detectable with traditional measures.

Quantum hacking on a practical continuous-variable quantum cryptosystem by inserting an external light

NASA Astrophysics Data System (ADS)

Qin, Hao; Kumar, Rupesh; Alleaume, Romain

2015-10-01

We report here a new side channel attack on a practical continuous-variable (CV) quantum key distribution (QKD) system. Inspired by blinding attack in discrete-variable QKD, we formalize an attack strategy by inserting an external light into a CV QKD system implemented Gaussian-modulated coherent state protocol and show that our attack can compromise its practical security. In this attack, we concern imperfections of a balanced homodyne detector used in CV QKD. According to our analysis, if one inserts an external light into Bob's signal port, due to the imperfect subtraction from the homodyne detector, the leakage of the external light contributes a displacement on the homodyne signal which causes detector electronics saturation. In consequence, Bob's quadrature measurement is not linear with the quadrature sent by Alice. By considering such vulnerability, a potential Eve can launch a full intercept-resend attack meanwhile she inserts an external light into Bob's signal port. By selecting proper properties of the external light, Eve actively controls the induced displacement value from the inserted light which results saturation of homodyne detection. In consequence, Eve can bias the excess noise due to the intercept-resend attack and the external light, such that Alice and Bob believe their excess noise estimation is below the null key threshold and they can still share a secret key. Our attack shows that the detector loopholes also exist in CV QKD, and it seems influence all the CV QKD systems using homodyne detection, since all the practical detectors have finite detection range.

Continuous DC-CIK infusions restore CD8+ cellular immunity, physical activity and improve clinical efficacy in advanced cancer patients unresponsive to conventional treatments.

PubMed

Zhao, Yan-Jie; Jiang, Ni; Song, Qing-Kun; Wu, Jiang-Ping; Song, Yu-Guang; Zhang, Hong-Mei; Chen, Feng; Zhou, Lei; Wang, Xiao-Li; Zhou, Xin-Na; Yang, Hua-Bing; Ren, Jun; Lyerly, Herbert Kim

2015-01-01

There are few choices for treatment of advanced cancer patients who do not respond to or tolerate conventional anti-cancer treatments. Therefore this study aimed to deploy the benefits and clinical efficacy of continuous dendritic cell-cytokine induced killer cell infusions in such patients. A total of 381 infusions (from 67 advanced cases recruited) were included in this study. All patients underwent peripheral blood mononuclear cell apheresis for the following cellular therapy and dendritic cells-cytokine induced killer cells were expanded in vitro. Peripheral blood T lymphocyte subsets were quantified through flow cytometry to address the cellular immunity status. Clinical efficacy and physical activities were evaluated by RECIST criteria and Eastern Cooperative Oncology Group scores respectively. Logistic regression model was used to estimate the association between cellular infusions and clinical benefits. An average of 5.7±2.94x10(9) induced cells were infused each time and patients were exposed to 6 infusions. Cellular immunity was improved in that cytotoxic CD8+CD28+T lymphocytes were increased by 74% and suppressive CD8+CD28-T lymphocytes were elevated by 16% (p<0.05). Continuous infusion of dendritic cells-cytokine induced killer cells was associated with improvement of both patient status and cellular immunity. A median of six infusions were capable of reducing risk of progression by 70% (95%CI 0.10-0.91). Every elevation of one ECOG score corresponded to a 3.90-fold higher progression risk (p<0.05) and 1% increase of CD8+CD28- T cell proportion reflecting a 5% higher risk of progression (p<0.05). In advanced cancer patients, continuous dendritic cell-cytokine induced killer cell infusions are capable of recovering cellular immunity, improving patient status and quality of life in those who are unresponsive to conventional cancer treatment.

Experimental investigation of criteria for continuous variable entanglement.

PubMed

Bowen, W P; Schnabel, R; Lam, P K; Ralph, T C

2003-01-31

We generate a pair of entangled beams from the interference of two amplitude squeezed beams. The entanglement is quantified in terms of EPR paradox and inseparability criteria, with both results clearly beating the standard quantum limit. We experimentally analyze the effect of decoherence on each criterion and demonstrate qualitative differences. We also characterize the number of required and excess photons present in the entangled beams and provide contour plots of the efficacy of quantum information protocols in terms of these variables.

Device for adapting continuously variable transmissions to infinitely variable transmissions with forward-neutral-reverse capabilities

DOEpatents

Wilkes, Donald F.; Purvis, James W.; Miller, A. Keith

1997-01-01

An infinitely variable transmission is capable of operating between a maximum speed in one direction and a minimum speed in an opposite direction, including a zero output angular velocity, while being supplied with energy at a constant angular velocity. Input energy is divided between a first power path carrying an orbital set of elements and a second path that includes a variable speed adjustment mechanism. The second power path also connects with the orbital set of elements in such a way as to vary the rate of angular rotation thereof. The combined effects of power from the first and second power paths are combined and delivered to an output element by the orbital element set. The transmission can be designed to operate over a preselected ratio of forward to reverse output speeds.

Modeling and mapping oak advance reproduction density using soil and site variables

Treesearch

John M. Kabrick; Jason L. Villwock; Daniel C. Dey; Tara L. Keyser; David R. Larsen

2014-01-01

Regenerating oaks (Quercus spp.) has remained a widespread and persistent problem throughout their natural range. Research shows that abundant oak advance reproduction is crucial for success. Although it is recognized that oak advance reproduction accumulation is inversely related to site quality, there has been little effort to model oak advance...

Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions.

PubMed

Cole, Kevin P; Groh, Jennifer McClary; Johnson, Martin D; Burcham, Christopher L; Campbell, Bradley M; Diseroad, William D; Heller, Michael R; Howell, John R; Kallman, Neil J; Koenig, Thomas M; May, Scott A; Miller, Richard D; Mitchell, David; Myers, David P; Myers, Steven S; Phillips, Joseph L; Polster, Christopher S; White, Timothy D; Cashman, Jim; Hurley, Declan; Moylan, Robert; Sheehan, Paul; Spencer, Richard D; Desmond, Kenneth; Desmond, Paul; Gowran, Olivia

2017-06-16

Advances in drug potency and tailored therapeutics are promoting pharmaceutical manufacturing to transition from a traditional batch paradigm to more flexible continuous processing. Here we report the development of a multistep continuous-flow CGMP (current good manufacturing practices) process that produced 24 kilograms of prexasertib monolactate monohydrate suitable for use in human clinical trials. Eight continuous unit operations were conducted to produce the target at roughly 3 kilograms per day using small continuous reactors, extractors, evaporators, crystallizers, and filters in laboratory fume hoods. Success was enabled by advances in chemistry, engineering, analytical science, process modeling, and equipment design. Substantial technical and business drivers were identified, which merited the continuous process. The continuous process afforded improved performance and safety relative to batch processes and also improved containment of a highly potent compound. Copyright © 2017, American Association for the Advancement of Science.

Green-up dates in the Tibetan Plateau have continuously advanced from 1982 to 2011

PubMed Central

Zhang, Yangjian; Dong, Jinwei; Xiao, Xiangming

2013-01-01

As the Earth’s third pole, the Tibetan Plateau has experienced a pronounced warming in the past decades. Recent studies reported that the start of the vegetation growing season (SOS) in the Plateau showed an advancing trend from 1982 to the late 1990s and a delay from the late 1990s to 2006. However, the findings regarding the SOS delay in the later period have been questioned, and the reasons causing the delay remain unknown. Here we explored the alpine vegetation SOS in the Plateau from 1982 to 2011 by integrating three long-term time-series datasets of Normalized Difference Vegetation Index (NDVI): Global Inventory Modeling and Mapping Studies (GIMMS, 1982–2006), SPOT VEGETATION (SPOT-VGT, 1998–2011), and Moderate Resolution Imaging Spectroradiometer (MODIS, 2000–2011). We found GIMMS NDVI in 2001–2006 differed substantially from SPOT-VGT and MODIS NDVIs and may have severe data quality issues in most parts of the western Plateau. By merging GIMMS-based SOSs from 1982 to 2000 with SPOT-VGT–based SOSs from 2001 to 2011 we found the alpine vegetation SOS in the Plateau experienced a continuous advancing trend at a rate of ∼1.04 d·y−1 from 1982 to 2011, which was consistent with observed warming in springs and winters. The satellite-derived SOSs were proven to be reliable with observed phenology data at 18 sites from 2003 to 2011; however, comparison of their trends was inconclusive due to the limited temporal coverage of the observed data. Longer-term observed data are still needed to validate the phenology trend in the future. PMID:23440201

Differing Roles of Functional Movement Variability as Experience Increases in Gymnastics

PubMed Central

Busquets, Albert; Marina, Michel; Davids, Keith; Angulo-Barroso, Rosa

2016-01-01

Current theories, like Ecological Dynamics, propose that inter-trial movement variability is functional when acquiring or refining movement coordination. Here, we examined how age-based experience levels of gymnasts constrained differences in emergent movement pattern variability during task performance. Specifically, we investigated different roles of movement pattern variability when gymnasts in different age groups performed longswings on a high bar, capturing the range of experience from beginner to advanced status. We also investigated the functionality of the relationships between levels of inter-trial variability and longswing amplitude during performance. One-hundred and thirteen male gymnasts in five age groups were observed performing longswings (with three different experience levels: beginners, intermediates and advanced performers). Performance was evaluated by analysis of key events in coordination of longswing focused on the arm-trunk and trunk-thigh segmental relations. Results revealed that 10 of 18 inter-trial variability measures changed significantly as a function of increasing task experience. Four of ten variability measures conformed to a U-shaped function with age implying exploratory strategies amongst beginners and functional adaptive variability amongst advanced performers. Inter-trial variability of arm-trunk coordination variables (6 of 10) conformed to a \\-shaped curve, as values were reduced to complete the longswings. Changes in coordination variability from beginner to intermediate status were largely restrictive, with only one variability measure related to exploration. Data revealed how inter-trial movement variability in gymnastics, relative to performance outcomes, needs careful interpretation, implying different roles as task experience changes. Key points Inter-trial variability while performing longswings on a high bar was assessed in a large sample (113 participants) divided into five age groups (form beginners to advanced

Continuous Low-Dose Oral Cyclophosphamide and Methotrexate as Maintenance Therapy in Patients With Advanced Ovarian Carcinoma After Complete Clinical Response to Platinum and Paclitaxel Chemotherapy.

PubMed

El-Husseiny, Khalid; Motawei, Helmy; Ali, Mohamad Sayed

2016-03-01

The aim of this study was to evaluate efficacy and safety of continuous, low dose of oral, metronomic chemotherapy as maintenance therapy in patients with advanced ovarian carcinoma after complete clinical response to platinum and paclitaxel chemotherapy. In this nonrandomized study, patients older than 18 years, with Eastern Cooperative Oncology Group performance status less than 2, with advanced ovarian carcinoma after complete clinical response to platinum and paclitaxel chemotherapy were enrolled in 2 arms--arm A (maintenance arm), treated with continuous low-dose oral cyclophosphamide 50 mg and methotrexate 2.5 mg, and arm B (observation arm). Both arms were followed up for progression-free survival and toxicity. Thirty patients were accrued in each arm from January 2009 to December 2010 in Ain Shams University Hospitals, where they received the treatment and followed up for disease progression and toxicity. Patients had a median age of 53 years in maintenance arm and 52.5 years in the observational arm, respectively. Over 80% had papillary serous adenocarcinoma, and over 40% of them had a stage IV disease in both arms. After median follow-up of 27 months, patients achieved median progression-free survival of 18 months in maintenance arm (A) and 15.5 months in observational arm (B), respectively. Toxicity profile was excellent with no grade 3 or 4 toxicity reported. Current study may provide an evidence of efficacy and tolerability of continuous low-dose oral cyclophosphamide and methotrexate as a maintenance therapy in patients with advanced ovarian carcinoma after complete clinical response to platinum and paclitaxel chemotherapy.

Continuous Improvement in Education. Advancing Teaching--Improving Learning. White Paper

ERIC Educational Resources Information Center

Park, Sandra; Hironaka, Stephanie; Carver, Penny; Nordstrum, Lee

2013-01-01

In recent years, "continuous improvement" has become a popular catchphrase in the field of education. However, while continuous improvement has become commonplace and well-documented in other industries, such as healthcare and manufacturing, little is known about how this work has manifested itself in education. This white paper attempts…

Translating Glucose Variability Metrics into the Clinic via Continuous Glucose Monitoring: A Graphical User Interface for Diabetes Evaluation (CGM-GUIDE©)

PubMed Central

Rawlings, Renata A.; Shi, Hang; Yuan, Lo-Hua; Brehm, William; Pop-Busui, Rodica

2011-01-01

Abstract Background Several metrics of glucose variability have been proposed to date, but an integrated approach that provides a complete and consistent assessment of glycemic variation is missing. As a consequence, and because of the tedious coding necessary during quantification, most investigators and clinicians have not yet adopted the use of multiple glucose variability metrics to evaluate glycemic variation. Methods We compiled the most extensively used statistical techniques and glucose variability metrics, with adjustable hyper- and hypoglycemic limits and metric parameters, to create a user-friendly Continuous Glucose Monitoring Graphical User Interface for Diabetes Evaluation (CGM-GUIDE©). In addition, we introduce and demonstrate a novel transition density profile that emphasizes the dynamics of transitions between defined glucose states. Results Our combined dashboard of numerical statistics and graphical plots support the task of providing an integrated approach to describing glycemic variability. We integrated existing metrics, such as SD, area under the curve, and mean amplitude of glycemic excursion, with novel metrics such as the slopes across critical transitions and the transition density profile to assess the severity and frequency of glucose transitions per day as they move between critical glycemic zones. Conclusions By presenting the above-mentioned metrics and graphics in a concise aggregate format, CGM-GUIDE provides an easy to use tool to compare quantitative measures of glucose variability. This tool can be used by researchers and clinicians to develop new algorithms of insulin delivery for patients with diabetes and to better explore the link between glucose variability and chronic diabetes complications. PMID:21932986

Advancing approaches for multi-year high-frequency monitoring of temporal and spatial variability in carbon cycle fluxes and drivers in freshwater lakes

NASA Astrophysics Data System (ADS)

Desai, A. R.; Reed, D. E.; Dugan, H. A.; Loken, L. C.; Schramm, P.; Golub, M.; Huerd, H.; Baldocchi, A. K.; Roberts, R.; Taebel, Z.; Hart, J.; Hanson, P. C.; Stanley, E. H.; Cartwright, E.

2017-12-01

Freshwater ecosystems are hotspots of regional to global carbon cycling. However, significant sample biases limit our ability to quantify and predict these fluxes. For lakes, scaled flux estimates suffer biased sampling toward 1) low-nutrient pristine lakes, 2) infrequent temporal sampling, 3) field campaigns limited to the growing season, and 4) replicates limited to near the center of the lake. While these biases partly reflect the realities of ecological sampling, there is a need to extend observations towards the large fraction of freshwater systems worldwide that are impaired by human activities and those facing significant interannual variability owing to climatic change. Also, for seasonally ice-covered lakes, much of the annual budget of carbon fluxes is thought to be explained by variation in the shoulder seasons of spring ice melt and fall turnover. Recent advances in automated, continuous multi-year temporal sampling coupled with rapid methods for spatial mapping of CO2 fluxes has strong potential to rectify these sampling biases. Here, we demonstrate these advances in an eutrophic seasonally-ice covered lake with an urban shoreline and agricultural watershed. Multiple years of half-hourly eddy covariance flux tower observations from two locations are coupled with frequent spatial samples of these fluxes and drivers by speedboat, floating chamber fluxes, automated buoy-based monitoring of lake nutrient and physical profiles, and ensemble of physical-ecosystem models. High primary productivity in the water column leads to an average net carbon sink during the growing season in much of the lake, but annual net carbon fluxes show the lake can act as an annual source or a sink of carbon depending the timing of spring and fall turnover. Trophic interactions and internal waves drive shorter-term variation while nutrients and biology drive seasonal variation. However, discrepancies remain among methods to quantify fluxes, requiring further investigation.

Recurrent neural network approach to quantum signal: coherent state restoration for continuous-variable quantum key distribution

NASA Astrophysics Data System (ADS)

Lu, Weizhao; Huang, Chunhui; Hou, Kun; Shi, Liting; Zhao, Huihui; Li, Zhengmei; Qiu, Jianfeng

2018-05-01

In continuous-variable quantum key distribution (CV-QKD), weak signal carrying information transmits from Alice to Bob; during this process it is easily influenced by unknown noise which reduces signal-to-noise ratio, and strongly impacts reliability and stability of the communication. Recurrent quantum neural network (RQNN) is an artificial neural network model which can perform stochastic filtering without any prior knowledge of the signal and noise. In this paper, a modified RQNN algorithm with expectation maximization algorithm is proposed to process the signal in CV-QKD, which follows the basic rule of quantum mechanics. After RQNN, noise power decreases about 15 dBm, coherent signal recognition rate of RQNN is 96%, quantum bit error rate (QBER) drops to 4%, which is 6.9% lower than original QBER, and channel capacity is notably enlarged.

First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data

NASA Astrophysics Data System (ADS)

Abbott, B. P.; Abbott, R.; Abbott, T. D.; Acernese, F.; Ackley, K.; Adams, C.; Adams, T.; Addesso, P.; Adhikari, R. X.; Adya, V. B.; Affeldt, C.; Afrough, M.; Agarwal, B.; Agathos, M.; Agatsuma, K.; Aggarwal, N.; Aguiar, O. D.; Aiello, L.; Ain, A.; Allen, B.; Allen, G.; Allocca, A.; Altin, P. A.; Amato, A.; Ananyeva, A.; Anderson, S. B.; Anderson, W. G.; Angelova, S. V.; Antier, S.; Appert, S.; Arai, K.; Araya, M. C.; Areeda, J. S.; Arnaud, N.; Arun, K. G.; Ascenzi, S.; Ashton, G.; Ast, M.; Aston, S. M.; Astone, P.; Atallah, D. V.; Aufmuth, P.; Aulbert, C.; AultONeal, K.; Austin, C.; Avila-Alvarez, A.; Babak, S.; Bacon, P.; Bader, M. K. M.; Bae, S.; Baker, P. T.; Baldaccini, F.; Ballardin, G.; Ballmer, S. W.; Banagiri, S.; Barayoga, J. C.; Barclay, S. E.; Barish, B. C.; Barker, D.; Barkett, K.; Barone, F.; Barr, B.; Barsotti, L.; Barsuglia, M.; Barta, D.; Bartlett, J.; Bartos, I.; Bassiri, R.; Basti, A.; Batch, J. C.; Bawaj, M.; Bayley, J. C.; Bazzan, M.; Bécsy, B.; Beer, C.; Bejger, M.; Belahcene, I.; Bell, A. S.; Berger, B. K.; Bergmann, G.; Bero, J. J.; Berry, C. P. L.; Bersanetti, D.; Bertolini, A.; Betzwieser, J.; Bhagwat, S.; Bhandare, R.; Bilenko, I. A.; Billingsley, G.; Billman, C. R.; Birch, J.; Birney, R.; Birnholtz, O.; Biscans, S.; Biscoveanu, S.; Bisht, A.; Bitossi, M.; Biwer, C.; Bizouard, M. A.; Blackburn, J. K.; Blackman, J.; Blair, C. D.; Blair, D. G.; Blair, R. M.; Bloemen, S.; Bock, O.; Bode, N.; Boer, M.; Bogaert, G.; Bohe, A.; Bondu, F.; Bonilla, E.; Bonnand, R.; Boom, B. A.; Bork, R.; Boschi, V.; Bose, S.; Bossie, K.; Bouffanais, Y.; Bozzi, A.; Bradaschia, C.; Brady, P. R.; Branchesi, M.; Brau, J. E.; Briant, T.; Brillet, A.; Brinkmann, M.; Brisson, V.; Brockill, P.; Broida, J. E.; Brooks, A. F.; Brown, D. A.; Brown, D. D.; Brunett, S.; Buchanan, C. C.; Buikema, A.; Bulik, T.; Bulten, H. J.; Buonanno, A.; Buskulic, D.; Buy, C.; Byer, R. L.; Cabero, M.; Cadonati, L.; Cagnoli, G.; Cahillane, C.; Calderón Bustillo, J.; Callister, T. A.; Calloni, E.; Camp, J. B.; Canizares, P.; Cannon, K. C.; Cao, H.; Cao, J.; Capano, C. D.; Capocasa, E.; Carbognani, F.; Caride, S.; Carney, M. F.; Casanueva Diaz, J.; Casentini, C.; Caudill, S.; Cavaglià, M.; Cavalier, F.; Cavalieri, R.; Cella, G.; Cepeda, C. B.; Cerdá-Durán, P.; Cerretani, G.; Cesarini, E.; Chamberlin, S. J.; Chan, M.; Chao, S.; Charlton, P.; Chase, E.; Chassande-Mottin, E.; Chatterjee, D.; Cheeseboro, B. D.; Chen, H. Y.; Chen, X.; Chen, Y.; Cheng, H.-P.; Chia, H.; Chincarini, A.; Chiummo, A.; Chmiel, T.; Cho, H. S.; Cho, M.; Chow, J. H.; Christensen, N.; Chu, Q.; Chua, A. J. K.; Chua, S.; Chung, A. K. W.; Chung, S.; Ciani, G.; Ciolfi, R.; Cirelli, C. E.; Cirone, A.; Clara, F.; Clark, J. A.; Clearwater, P.; Cleva, F.; Cocchieri, C.; Coccia, E.; Cohadon, P.-F.; Cohen, D.; Colla, A.; Collette, C. G.; Cominsky, L. R.; Constancio, M.; Conti, L.; Cooper, S. J.; Corban, P.; Corbitt, T. R.; Cordero-Carrión, I.; Corley, K. R.; Cornish, N.; Corsi, A.; Cortese, S.; Costa, C. A.; Coughlin, M. W.; Coughlin, S. B.; Coulon, J.-P.; Countryman, S. T.; Couvares, P.; Covas, P. B.; Cowan, E. E.; Coward, D. M.; Cowart, M. J.; Coyne, D. C.; Coyne, R.; Creighton, J. D. E.; Creighton, T. D.; Cripe, J.; Crowder, S. G.; Cullen, T. J.; Cumming, A.; Cunningham, L.; Cuoco, E.; Dal Canton, T.; Dálya, G.; Danilishin, S. L.; D'Antonio, S.; Danzmann, K.; Dasgupta, A.; Da Silva Costa, C. F.; Dattilo, V.; Dave, I.; Davier, M.; Davis, D.; Daw, E. J.; Day, B.; De, S.; DeBra, D.; Degallaix, J.; De Laurentis, M.; Deléglise, S.; Del Pozzo, W.; Demos, N.; Denker, T.; Dent, T.; De Pietri, R.; Dergachev, V.; De Rosa, R.; DeRosa, R. T.; De Rossi, C.; DeSalvo, R.; de Varona, O.; Devenson, J.; Dhurandhar, S.; Díaz, M. C.; Di Fiore, L.; Di Giovanni, M.; Di Girolamo, T.; Di Lieto, A.; Di Pace, S.; Di Palma, I.; Di Renzo, F.; Doctor, Z.; Dolique, V.; Donovan, F.; Dooley, K. L.; Doravari, S.; Dorrington, I.; Douglas, R.; Dovale Álvarez, M.; Downes, T. P.; Drago, M.; Dreissigacker, C.; Driggers, J. C.; Du, Z.; Ducrot, M.; Dupej, P.; Dwyer, S. E.; Edo, T. B.; Edwards, M. C.; Effler, A.; Eggenstein, H.-B.; Ehrens, P.; Eichholz, J.; Eikenberry, S. S.; Eisenstein, R. A.; Essick, R. C.; Estevez, D.; Etienne, Z. B.; Etzel, T.; Evans, M.; Evans, T. M.; Factourovich, M.; Fafone, V.; Fair, H.; Fairhurst, S.; Fan, X.; Farinon, S.; Farr, B.; Farr, W. M.; Fauchon-Jones, E. J.; Favata, M.; Fays, M.; Fee, C.; Fehrmann, H.; Feicht, J.; Fejer, M. M.; Fernandez-Galiana, A.; Ferrante, I.; Ferreira, E. C.; Ferrini, F.; Fidecaro, F.; Finstad, D.; Fiori, I.; Fiorucci, D.; Fishbach, M.; Fisher, R. P.; Fitz-Axen, M.; Flaminio, R.; Fletcher, M.; Fong, H.; Font, J. A.; Forsyth, P. W. F.; Forsyth, S. S.; Fournier, J.-D.; Frasca, S.; Frasconi, F.; Frei, Z.; Freise, A.; Frey, R.; Frey, V.; Fries, E. M.; Fritschel, P.; Frolov, V. V.; Fulda, P.; Fyffe, M.; Gabbard, H.; Gadre, B. U.; Gaebel, S. M.; Gair, J. R.; Gammaitoni, L.; Ganija, M. R.; Gaonkar, S. G.; Garcia-Quiros, C.; Garufi, F.; Gateley, B.; Gaudio, S.; Gaur, G.; Gayathri, V.; Gehrels, N.; Gemme, G.; Genin, E.; Gennai, A.; George, D.; George, J.; Gergely, L.; Germain, V.; Ghonge, S.; Ghosh, Abhirup; Ghosh, Archisman; Ghosh, S.; Giaime, J. A.; Giardina, K. D.; Giazotto, A.; Gill, K.; Glover, L.; Goetz, E.; Goetz, R.; Gomes, S.; Goncharov, B.; González, G.; Gonzalez Castro, J. M.; Gopakumar, A.; Gorodetsky, M. L.; Gossan, S. E.; Gosselin, M.; Gouaty, R.; Grado, A.; Graef, C.; Granata, M.; Grant, A.; Gras, S.; Gray, C.; Greco, G.; Green, A. C.; Gretarsson, E. M.; Groot, P.; Grote, H.; Grunewald, S.; Gruning, P.; Guidi, G. M.; Guo, X.; Gupta, A.; Gupta, M. K.; Gushwa, K. E.; Gustafson, E. K.; Gustafson, R.; Halim, O.; Hall, B. R.; Hall, E. D.; Hamilton, E. Z.; Hammond, G.; Haney, M.; Hanke, M. M.; Hanks, J.; Hanna, C.; Hannam, M. D.; Hannuksela, O. A.; Hanson, J.; Hardwick, T.; Harms, J.; Harry, G. M.; Harry, I. W.; Hart, M. J.; Haster, C.-J.; Haughian, K.; Healy, J.; Heidmann, A.; Heintze, M. C.; Heitmann, H.; Hello, P.; Hemming, G.; Hendry, M.; Heng, I. S.; Hennig, J.; Heptonstall, A. W.; Heurs, M.; Hild, S.; Hinderer, T.; Ho, W. C. G.; Hoak, D.; Hofman, D.; Holt, K.; Holz, D. E.; Hopkins, P.; Horst, C.; Hough, J.; Houston, E. A.; Howell, E. J.; Hreibi, A.; Hu, Y. M.; Huerta, E. A.; Huet, D.; Hughey, B.; Husa, S.; Huttner, S. H.; Huynh-Dinh, T.; Indik, N.; Inta, R.; Intini, G.; Isa, H. N.; Isac, J.-M.; Isi, M.; Iyer, B. R.; Izumi, K.; Jacqmin, T.; Jani, K.; Jaranowski, P.; Jawahar, S.; Jiménez-Forteza, F.; Johnson, W. W.; Jones, D. I.; Jones, R.; Jonker, R. J. G.; Ju, L.; Junker, J.; Kalaghatgi, C. V.; Kalogera, V.; Kamai, B.; Kandhasamy, S.; Kang, G.; Kanner, J. B.; Kapadia, S. J.; Karki, S.; Karvinen, K. S.; Kasprzack, M.; Katolik, M.; Katsavounidis, E.; Katzman, W.; Kaufer, S.; Kawabe, K.; Kéfélian, F.; Keitel, D.; Kemball, A. J.; Kennedy, R.; Kent, C.; Key, J. S.; Khalili, F. Y.; Khan, I.; Khan, S.; Khan, Z.; Khazanov, E. A.; Kijbunchoo, N.; Kim, Chunglee; Kim, J. C.; Kim, K.; Kim, W.; Kim, W. S.; Kim, Y.-M.; Kimbrell, S. J.; King, E. J.; King, P. J.; Kinley-Hanlon, M.; Kirchhoff, R.; Kissel, J. S.; Kleybolte, L.; Klimenko, S.; Knowles, T. D.; Koch, P.; Koehlenbeck, S. M.; Koley, S.; Kondrashov, V.; Kontos, A.; Korobko, M.; Korth, W. Z.; Kowalska, I.; Kozak, D. B.; Krämer, C.; Kringel, V.; Krishnan, B.; Królak, A.; Kuehn, G.; Kumar, P.; Kumar, R.; Kumar, S.; Kuo, L.; Kutynia, A.; Kwang, S.; Lackey, B. D.; Lai, K. H.; Landry, M.; Lang, R. N.; Lange, J.; Lantz, B.; Lanza, R. K.; Lartaux-Vollard, A.; Lasky, P. D.; Laxen, M.; Lazzarini, A.; Lazzaro, C.; Leaci, P.; Leavey, S.; Lee, C. H.; Lee, H. K.; Lee, H. M.; Lee, H. W.; Lee, K.; Lehmann, J.; Lenon, A.; Leonardi, M.; Leroy, N.; Letendre, N.; Levin, Y.; Li, T. G. F.; Linker, S. D.; Littenberg, T. B.; Liu, J.; Lo, R. K. L.; Lockerbie, N. A.; London, L. T.; Lord, J. E.; Lorenzini, M.; Loriette, V.; Lormand, M.; Losurdo, G.; Lough, J. D.; Lovelace, G.; Lück, H.; Lumaca, D.; Lundgren, A. P.; Lynch, R.; Ma, Y.; Macas, R.; Macfoy, S.; Machenschalk, B.; MacInnis, M.; Macleod, D. M.; Magaña Hernandez, I.; Magaña-Sandoval, F.; Magaña Zertuche, L.; Magee, R. M.; Majorana, E.; Maksimovic, I.; Man, N.; Mandic, V.; Mangano, V.; Mansell, G. L.; Manske, M.; Mantovani, M.; Marchesoni, F.; Marion, F.; Márka, S.; Márka, Z.; Markakis, C.; Markosyan, A. S.; Markowitz, A.; Maros, E.; Marquina, A.; Martelli, F.; Martellini, L.; Martin, I. W.; Martin, R. M.; Martynov, D. V.; Mason, K.; Massera, E.; Masserot, A.; Massinger, T. J.; Masso-Reid, M.; Mastrogiovanni, S.; Matas, A.; Matichard, F.; Matone, L.; Mavalvala, N.; Mazumder, N.; McCarthy, R.; McClelland, D. E.; McCormick, S.; McCuller, L.; McGuire, S. C.; McIntyre, G.; McIver, J.; McManus, D. J.; McNeill, L.; McRae, T.; McWilliams, S. T.; Meacher, D.; Meadors, G. D.; Mehmet, M.; Meidam, J.; Mejuto-Villa, E.; Melatos, A.; Mendell, G.; Mercer, R. A.; Merilh, E. L.; Merzougui, M.; Meshkov, S.; Messenger, C.; Messick, C.; Metzdorff, R.; Meyers, P. M.; Miao, H.; Michel, C.; Middleton, H.; Mikhailov, E. E.; Milano, L.; Miller, A. L.; Miller, B. B.; Miller, J.; Millhouse, M.; Milovich-Goff, M. C.; Minazzoli, O.; Minenkov, Y.; Ming, J.; Mishra, C.; Mitra, S.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Moffa, D.; Moggi, A.; Mogushi, K.; Mohan, M.; Mohapatra, S. R. P.; Montani, M.; Moore, C. J.; Moraru, D.; Moreno, G.; Morriss, S. R.; Mours, B.; Mow-Lowry, C. M.; Mueller, G.; Muir, A. W.; Mukherjee, Arunava; Mukherjee, D.; Mukherjee, S.; Mukund, N.; Mullavey, A.; Munch, J.; Muñiz, E. A.; Muratore, M.; Murray, P. G.; Napier, K.; Nardecchia, I.; Naticchioni, L.; Nayak, R. K.; Neilson, J.; Nelemans, G.; Nelson, T. J. N.; Nery, M.; Neunzert, A.; Nevin, L.; Newport, J. M.; Newton, G.; Ng, K. K. Y.; Nguyen, T. T.; Nichols, D.; Nielsen, A. B.; Nissanke, S.; Nitz, A.; Noack, A.; Nocera, F.; Nolting, D.; North, C.; Nuttall, L. K.; Oberling, J.; O'Dea, G. D.; Ogin, G. H.; Oh, J. J.; Oh, S. H.; Ohme, F.; Okada, M. A.; Oliver, M.; Oppermann, P.; Oram, Richard J.; O'Reilly, B.; Ormiston, R.; Ortega, L. F.; O'Shaughnessy, R.; Ossokine, S.; Ottaway, D. J.; Overmier, H.; Owen, B. J.; Pace, A. E.; Page, J.; Page, M. A.; Pai, A.; Pai, S. A.; Palamos, J. R.; Palashov, O.; Palomba, C.; Pal-Singh, A.; Pan, Howard; Pan, Huang-Wei; Pang, B.; Pang, P. T. H.; Pankow, C.; Pannarale, F.; Pant, B. C.; Paoletti, F.; Paoli, A.; Papa, M. A.; Parida, A.; Parker, W.; Pascucci, D.; Pasqualetti, A.; Passaquieti, R.; Passuello, D.; Patil, M.; Patricelli, B.; Pearlstone, B. L.; Pedraza, M.; Pedurand, R.; Pekowsky, L.; Pele, A.; Penn, S.; Perez, C. J.; Perreca, A.; Perri, L. M.; Pfeiffer, H. P.; Phelps, M.; Piccinni, O. J.; Pichot, M.; Piergiovanni, F.; Pierro, V.; Pillant, G.; Pinard, L.; Pinto, I. M.; Pirello, M.; Pitkin, M.; Poe, M.; Poggiani, R.; Popolizio, P.; Porter, E. K.; Post, A.; Powell, J.; Prasad, J.; Pratt, J. W. W.; Pratten, G.; Predoi, V.; Prestegard, T.; Prijatelj, M.; Principe, M.; Privitera, S.; Prodi, G. A.; Prokhorov, L. G.; Puncken, O.; Punturo, M.; Puppo, P.; Pürrer, M.; Qi, H.; Quetschke, V.; Quintero, E. A.; Quitzow-James, R.; Raab, F. J.; Rabeling, D. S.; Radkins, H.; Raffai, P.; Raja, S.; Rajan, C.; Rajbhandari, B.; Rakhmanov, M.; Ramirez, K. E.; Ramos-Buades, A.; Rapagnani, P.; Raymond, V.; Razzano, M.; Read, J.; Regimbau, T.; Rei, L.; Reid, S.; Reitze, D. H.; Ren, W.; Reyes, S. D.; Ricci, F.; Ricker, P. M.; Rieger, S.; Riles, K.; Rizzo, M.; Robertson, N. A.; Robie, R.; Robinet, F.; Rocchi, A.; Rolland, L.; Rollins, J. G.; Roma, V. J.; Romano, R.; Romel, C. L.; Romie, J. H.; Rosińska, D.; Ross, M. P.; Rowan, S.; Rüdiger, A.; Ruggi, P.; Rutins, G.; Ryan, K.; Sachdev, S.; Sadecki, T.; Sadeghian, L.; Sakellariadou, M.; Salconi, L.; Saleem, M.; Salemi, F.; Samajdar, A.; Sammut, L.; Sampson, L. M.; Sanchez, E. J.; Sanchez, L. E.; Sanchis-Gual, N.; Sandberg, V.; Sanders, J. R.; Sassolas, B.; Sathyaprakash, B. S.; Saulson, P. R.; Sauter, O.; Savage, R. L.; Sawadsky, A.; Schale, P.; Scheel, M.; Scheuer, J.; Schmidt, J.; Schmidt, P.; Schnabel, R.; Schofield, R. M. S.; Schönbeck, A.; Schreiber, E.; Schuette, D.; Schulte, B. W.; Schutz, B. F.; Schwalbe, S. G.; Scott, J.; Scott, S. M.; Seidel, E.; Sellers, D.; Sengupta, A. S.; Sentenac, D.; Sequino, V.; Sergeev, A.; Shaddock, D. A.; Shaffer, T. J.; Shah, A. A.; Shahriar, M. S.; Shaner, M. B.; Shao, L.; Shapiro, B.; Shawhan, P.; Sheperd, A.; Shoemaker, D. H.; Shoemaker, D. M.; Siellez, K.; Siemens, X.; Sieniawska, M.; Sigg, D.; Silva, A. D.; Singer, L. P.; Singh, A.; Singhal, A.; Sintes, A. M.; Slagmolen, B. J. J.; Smith, B.; Smith, J. R.; Smith, R. J. E.; Somala, S.; Son, E. J.; Sonnenberg, J. A.; Sorazu, B.; Sorrentino, F.; Souradeep, T.; Spencer, A. P.; Srivastava, A. K.; Staats, K.; Staley, A.; Steinke, M.; Steinlechner, J.; Steinlechner, S.; Steinmeyer, D.; Stevenson, S. P.; Stone, R.; Stops, D. J.; Strain, K. A.; Stratta, G.; Strigin, S. E.; Strunk, A.; Sturani, R.; Stuver, A. L.; Summerscales, T. Z.; Sun, L.; Sunil, S.; Suresh, J.; Sutton, P. J.; Swinkels, B. L.; Szczepańczyk, M. J.; Tacca, M.; Tait, S. C.; Talbot, C.; Talukder, D.; Tanner, D. B.; Tápai, M.; Taracchini, A.; Tasson, J. D.; Taylor, J. A.; Taylor, R.; Tewari, S. V.; Theeg, T.; Thies, F.; Thomas, E. G.; Thomas, M.; Thomas, P.; Thorne, K. A.; Thrane, E.; Tiwari, S.; Tiwari, V.; Tokmakov, K. V.; Toland, K.; Tonelli, M.; Tornasi, Z.; Torres-Forné, A.; Torrie, C. I.; Töyrä, D.; Travasso, F.; Traylor, G.; Trinastic, J.; Tringali, M. C.; Trozzo, L.; Tsang, K. W.; Tse, M.; Tso, R.; Tsukada, L.; Tsuna, D.; Tuyenbayev, D.; Ueno, K.; Ugolini, D.; Unnikrishnan, C. S.; Urban, A. L.; Usman, S. A.; Vahlbruch, H.; Vajente, G.; Valdes, G.; van Bakel, N.; van Beuzekom, M.; van den Brand, J. F. J.; Van Den Broeck, C.; Vander-Hyde, D. C.; van der Schaaf, L.; van Heijningen, J. V.; van Veggel, A. A.; Vardaro, M.; Varma, V.; Vass, S.; Vasúth, M.; Vecchio, A.; Vedovato, G.; Veitch, J.; Veitch, P. J.; Venkateswara, K.; Venugopalan, G.; Verkindt, D.; Vetrano, F.; Viceré, A.; Viets, A. D.; Vinciguerra, S.; Vine, D. J.; Vinet, J.-Y.; Vitale, S.; Vo, T.; Vocca, H.; Vorvick, C.; Vyatchanin, S. P.; Wade, A. R.; Wade, L. E.; Wade, M.; Walet, R.; Walker, M.; Wallace, L.; Walsh, S.; Wang, G.; Wang, H.; Wang, J. Z.; Wang, W. H.; Wang, Y. F.; Ward, R. L.; Warner, J.; Was, M.; Watchi, J.; Weaver, B.; Wei, L.-W.; Weinert, M.; Weinstein, A. J.; Weiss, R.; Wen, L.; Wessel, E. K.; Weßels, P.; Westerweck, J.; Westphal, T.; Wette, K.; Whelan, J. T.; Whiting, B. F.; Whittle, C.; Wilken, D.; Williams, D.; Williams, R. D.; Williamson, A. R.; Willis, J. L.; Willke, B.; Wimmer, M. H.; Winkler, W.; Wipf, C. C.; Wittel, H.; Woan, G.; Woehler, J.; Wofford, J.; Wong, K. W. K.; Worden, J.; Wright, J. L.; Wu, D. S.; Wysocki, D. M.; Xiao, S.; Yamamoto, H.; Yancey, C. C.; Yang, L.; Yap, M. J.; Yazback, M.; Yu, Hang; Yu, Haocun; Yvert, M.; ZadroŻny, A.; Zanolin, M.; Zelenova, T.; Zendri, J.-P.; Zevin, M.; Zhang, L.; Zhang, M.; Zhang, T.; Zhang, Y.-H.; Zhao, C.; Zhou, M.; Zhou, Z.; Zhu, S. J.; Zhu, X. J.; Zucker, M. E.; Zweizig, J.; LIGO Scientific Collaboration; Virgo Collaboration

2017-12-01

Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signal-to-noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11 pulsars using data from Advanced LIGO's first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far.

Continuous-time ΣΔ ADC with implicit variable gain amplifier for CMOS image sensor.

PubMed

Tang, Fang; Bermak, Amine; Abbes, Amira; Benammar, Mohieddine Amor

2014-01-01

This paper presents a column-parallel continuous-time sigma delta (CTSD) ADC for mega-pixel resolution CMOS image sensor (CIS). The sigma delta modulator is implemented with a 2nd order resistor/capacitor-based loop filter. The first integrator uses a conventional operational transconductance amplifier (OTA), for the concern of a high power noise rejection. The second integrator is realized with a single-ended inverter-based amplifier, instead of a standard OTA. As a result, the power consumption is reduced, without sacrificing the noise performance. Moreover, the variable gain amplifier in the traditional column-parallel read-out circuit is merged into the front-end of the CTSD modulator. By programming the input resistance, the amplitude range of the input current can be tuned with 8 scales, which is equivalent to a traditional 2-bit preamplification function without consuming extra power and chip area. The test chip prototype is fabricated using 0.18 μm CMOS process and the measurement result shows an ADC power consumption lower than 63.5 μW under 1.4 V power supply and 50 MHz clock frequency.

Entanglement-distillation attack on continuous-variable quantum key distribution in a turbulent atmospheric channel

NASA Astrophysics Data System (ADS)

Guo, Ying; Xie, Cailang; Liao, Qin; Zhao, Wei; Zeng, Guihua; Huang, Duan

2017-08-01

The survival of Gaussian quantum states in a turbulent atmospheric channel is of crucial importance in free-space continuous-variable (CV) quantum key distribution (QKD), in which the transmission coefficient will fluctuate in time, thus resulting in non-Gaussian quantum states. Different from quantum hacking of the imperfections of practical devices, here we propose a different type of attack by exploiting the security loopholes that occur in a real lossy channel. Under a turbulent atmospheric environment, the Gaussian states are inevitably afflicted by decoherence, which would cause a degradation of the transmitted entanglement. Therefore, an eavesdropper can perform an intercept-resend attack by applying an entanglement-distillation operation on the transmitted non-Gaussian mixed states, which allows the eavesdropper to bias the estimation of the parameters and renders the final keys shared between the legitimate parties insecure. Our proposal highlights the practical CV QKD vulnerabilities with free-space quantum channels, including the satellite-to-earth links, ground-to-ground links, and a link from moving objects to ground stations.

Cardiac autonomic modulation impairments in advanced breast cancer patients.

PubMed

Arab, Claudia; Vanderlei, Luiz Carlos Marques; da Silva Paiva, Laércio; Fulghum, Kyle Levi; Fristachi, Carlos Elias; Nazario, Afonso Celso Pinto; Elias, Simone; Gebrim, Luiz Henrique; Ferreira Filho, Celso; Gidron, Yori; Ferreira, Celso

2018-05-02

To compare cardiac autonomic modulation in early- versus advanced-stage breast cancer patients before any type of cancer treatment and investigate associated factors. This cross-sectional study included women (30-69 years old) with primary diagnosis of breast cancer and women with benign breast tumors. We evaluated cardiac modulation by heart rate variability and assessed factors of anxiety, depression, physical activity, and other relevant medical variables. Patients were divided into three groups based on TNM staging of cancer severity: early-stage cancer (n = 42), advanced-stage cancer (n = 37), or benign breast tumors to serve as a control (n = 37). We analyzed heart rate variability in time and frequency domains. The advanced-stage cancer group had lower vagal modulation than early-stage and benign groups; also, the advance-stage group had lower overall heart rate variability when compared to benign conditions. Heart rate variability was influenced by age, menopausal status, and BMI. Heart rate variability seems to be a promising, non-invasive tool for early diagnosis of autonomic dysfunction in breast cancer and detection of cardiovascular impairments at cancer diagnosis. Cardiac autonomic modulation is inversely associated with breast cancer staging.

Continuous 7-Days-A-Week External Beam Irradiation in Locally Advanced Cervical Cancer: Final Results of the Phase I/II Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Serkies, Krystyna, E-mail: kserkies@wp.pl; Dziadziuszko, Rafal; Jassem, Jacek

2012-03-01

Purpose: To evaluate the feasibility and efficacy of definitive continuous 7-days-a-week pelvic irradiation without breaks between external beam radiotherapy and brachytherapy in locally advanced cervical cancer. Methods and Materials: Between November 1998 and December 1999, 30 patients with International Federation of Obstetrics and Gynecology Stage IIB or IIIB cervical cancer were included in a prospective Phase I/II study of continuous 7-days-a-week pelvic irradiation, to the total Manchester point B dose of 40.0-57.6 Gy. The first 13 patients (Group A) were given a daily tumor dose of 1.6 Gy, and the remaining 17 patients (Group B) were given 1.8 Gy. Onemore » or two immediate brachytherapy applications (point A dose 10-20 Gy, each) were performed in 28 cases. Results: Two patients did not complete the irradiation because of apparent early progression of disease during the irradiation. Eleven of the 28 evaluable patients (39%; 45% and 35% in Groups A and B, respectively) completed their treatment within the prescribed overall treatment time. Acute toxicity (including severe European Organisation for Research and Treatment of Cancer/Radiation Therapy Oncology Group Grade 3 and 4 effects in 40%) was experienced by 83% of patients and resulted in unplanned treatment interruptions in 40% of all patients (31% and 47% of patients in Groups A and B, respectively). Severe intestinal side effects occurred in 31% and 41% of Patients in Groups A and B, respectively (p = 0.71). The 5-year overall survival probability was 33%. Cancer recurrence occurred in 63% of patients: 20% inside and 57% outside the pelvis. Cumulative incidence of late severe bowel and urinary bladder toxicity at 24 months was 15%. Conclusion: Continuous irradiation in locally advanced cervical cancer is associated with a high incidence of severe acute toxicity, resulting in unplanned treatment interruptions. Late severe effects and survival after continuous radiotherapy do not substantially differ

SSAGES: Software Suite for Advanced General Ensemble Simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sidky, Hythem; Colón, Yamil J.; Helfferich, Julian

Molecular simulation has emerged as an essential tool for modern-day research, but obtaining proper results and making reliable conclusions from simulations requires adequate sampling of the system under consideration. To this end, a variety of methods exist in the literature that can enhance sampling considerably, and increasingly sophisticated, effective algorithms continue to be developed at a rapid pace. Implementation of these techniques, however, can be challenging for experts and non-experts alike. There is a clear need for software that provides rapid, reliable, and easy access to a wide range of advanced sampling methods, and that facilitates implementation of new techniquesmore » as they emerge. Here we present SSAGES, a publicly available Software Suite for Advanced General Ensemble Simulations designed to interface with multiple widely used molecular dynamics simulations packages. SSAGES allows facile application of a variety of enhanced sampling techniques—including adaptive biasing force, string methods, and forward flux sampling—that extract meaningful free energy and transition path data from all-atom and coarse grained simulations. A noteworthy feature of SSAGES is a user-friendly framework that facilitates further development and implementation of new methods and collective variables. In this work, the use of SSAGES is illustrated in the context of simple representative applications involving distinct methods and different collective variables that are available in the current release of the suite.« less

Advanced Welding Applications

NASA Technical Reports Server (NTRS)

Ding, Robert J.

2010-01-01

Some of the applications of advanced welding techniques are shown in this poster presentation. Included are brief explanations of the use on the Ares I and Ares V launch vehicle and on the Space Shuttle Launch vehicle. Also included are microstructural views from four advanced welding techniques: Variable Polarity Plasma Arc (VPPA) weld (fusion), self-reacting friction stir welding (SR-FSW), conventional FSW, and Tube Socket Weld (TSW) on aluminum.

Operator- and software-related post-experimental variability and source of error in 2-DE analysis.

PubMed

Millioni, Renato; Puricelli, Lucia; Sbrignadello, Stefano; Iori, Elisabetta; Murphy, Ellen; Tessari, Paolo

2012-05-01

In the field of proteomics, several approaches have been developed for separating proteins and analyzing their differential relative abundance. One of the oldest, yet still widely used, is 2-DE. Despite the continuous advance of new methods, which are less demanding from a technical standpoint, 2-DE is still compelling and has a lot of potential for improvement. The overall variability which affects 2-DE includes biological, experimental, and post-experimental (software-related) variance. It is important to highlight how much of the total variability of this technique is due to post-experimental variability, which, so far, has been largely neglected. In this short review, we have focused on this topic and explained that post-experimental variability and source of error can be further divided into those which are software-dependent and those which are operator-dependent. We discuss these issues in detail, offering suggestions for reducing errors that may affect the quality of results, summarizing the advantages and drawbacks of each approach.

Advanced supersonic propulsion study, phase 3

NASA Technical Reports Server (NTRS)

Howlett, R. A.; Johnson, J.; Sabatella, J.; Sewall, T.

1976-01-01

The variable stream control engine is determined to be the most promising propulsion system concept for advanced supersonic cruise aircraft. This concept uses variable geometry components and a unique throttle schedule for independent control of two flow streams to provide low jet noise at takeoff and high performance at both subsonic and supersonic cruise. The advanced technology offers a 25% improvement in airplane range and an 8 decibel reduction in takeoff noise, relative to first generation supersonic turbojet engines.

How Robust Is Linear Regression with Dummy Variables?

ERIC Educational Resources Information Center

Blankmeyer, Eric

2006-01-01

Researchers in education and the social sciences make extensive use of linear regression models in which the dependent variable is continuous-valued while the explanatory variables are a combination of continuous-valued regressors and dummy variables. The dummies partition the sample into groups, some of which may contain only a few observations.…

Stratigraphy -- The Fall of Continuity.

ERIC Educational Resources Information Center

Byers, Charles W.

1982-01-01

Reviews advances in stratigraphy as illustrated in the current geological literature, discussing discontinuity and how the recognition of discontinuity in the stratigraphic record is changing views of Superposition and Original Lateral Continuity. (Author/JN)

Generating the Local Oscillator "Locally" in Continuous-Variable Quantum Key Distribution Based on Coherent Detection

NASA Astrophysics Data System (ADS)

Qi, Bing; Lougovski, Pavel; Pooser, Raphael; Grice, Warren; Bobrek, Miljko

2015-10-01

Continuous-variable quantum key distribution (CV-QKD) protocols based on coherent detection have been studied extensively in both theory and experiment. In all the existing implementations of CV-QKD, both the quantum signal and the local oscillator (LO) are generated from the same laser and propagate through the insecure quantum channel. This arrangement may open security loopholes and limit the potential applications of CV-QKD. In this paper, we propose and demonstrate a pilot-aided feedforward data recovery scheme that enables reliable coherent detection using a "locally" generated LO. Using two independent commercial laser sources and a spool of 25-km optical fiber, we construct a coherent communication system. The variance of the phase noise introduced by the proposed scheme is measured to be 0.04 (rad2 ), which is small enough to enable secure key distribution. This technology also opens the door for other quantum communication protocols, such as the recently proposed measurement-device-independent CV-QKD, where independent light sources are employed by different users.

High-speed free-space optical continuous-variable quantum key distribution enabled by three-dimensional multiplexing.

PubMed

Qu, Zhen; Djordjevic, Ivan B

2017-04-03

A high-speed four-state continuous-variable quantum key distribution (CV-QKD) system, enabled by wavelength-division multiplexing, polarization multiplexing, and orbital angular momentum (OAM) multiplexing, is studied in the presence of atmospheric turbulence. The atmospheric turbulence channel is emulated by two spatial light modulators (SLMs) on which two randomly generated azimuthal phase patterns yielding Andrews' spectrum are recorded. The phase noise is mitigated by the phase noise cancellation (PNC) stage, and channel transmittance can be monitored directly by the D.C. level in our PNC stage. After the system calibration, a total SKR of >1.68 Gbit/s can be reached in the ideal system, featured with lossless channel and free of excess noise. In our experiment, based on commercial photodetectors, the minimum transmittances of 0.21 and 0.29 are required for OAM states of 2 (or -2) and 6 (or -6), respectively, to guarantee the secure transmission, while a total SKR of 120 Mbit/s can be obtained in case of mean transmittances.

Universal analytical scattering form factor for shell-, core-shell, or homogeneous particles with continuously variable density profile shape.

PubMed

Foster, Tobias

2011-09-01

A novel analytical and continuous density distribution function with a widely variable shape is reported and used to derive an analytical scattering form factor that allows us to universally describe the scattering from particles with the radial density profile of homogeneous spheres, shells, or core-shell particles. Composed by the sum of two Fermi-Dirac distribution functions, the shape of the density profile can be altered continuously from step-like via Gaussian-like or parabolic to asymptotically hyperbolic by varying a single "shape parameter", d. Using this density profile, the scattering form factor can be calculated numerically. An analytical form factor can be derived using an approximate expression for the original Fermi-Dirac distribution function. This approximation is accurate for sufficiently small rescaled shape parameters, d/R (R being the particle radius), up to values of d/R ≈ 0.1, and thus captures step-like, Gaussian-like, and parabolic as well as asymptotically hyperbolic profile shapes. It is expected that this form factor is particularly useful in a model-dependent analysis of small-angle scattering data since the applied continuous and analytical function for the particle density profile can be compared directly with the density profile extracted from the data by model-free approaches like the generalized inverse Fourier transform method. © 2011 American Chemical Society

Fully integrated biochip platforms for advanced healthcare.

PubMed

Carrara, Sandro; Ghoreishizadeh, Sara; Olivo, Jacopo; Taurino, Irene; Baj-Rossi, Camilla; Cavallini, Andrea; de Beeck, Maaike Op; Dehollain, Catherine; Burleson, Wayne; Moussy, Francis Gabriel; Guiseppi-Elie, Anthony; De Micheli, Giovanni

2012-01-01

Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

Nurses' Internet self-efficacy and attitudes toward web-based continuing learning.

PubMed

Liang, Jyh-Chong; Wu, Szu-Hsien; Tsai, Chin-Chung

2011-11-01

There are increasing opportunities for nurses to engage in continuing learning via the Internet; hence, it is important to explore nurses' attitudes toward web-based continuing learning. This paper explores 267 Taiwanese clinical nurses' attitudes toward web-based continuing learning. In addition, the role of the nurses' Internet self-efficacy in their attitudes is investigated. This study utilizes two questionnaires to respectively survey the nurses' Internet self-efficacy and their attitudes toward web-based continuing learning. In particular, the Internet Self-efficacy Survey includes two scales: 'Basic self-efficacy' (the perceived confidence of using basic Internet functions, such as the confidence in using a web browser or searching for online information) and 'Advanced self-efficacy' (the perceived confidence of using advanced Internet functions, such as the confidence in online discussion or making online payments). Exploratory factor analyses indicated adequate reliability and validity of the two questionnaires. The regression analyses revealed that both nurses' basic and advanced Internet self-efficacy can positively explain the perceived usefulness, ease of use and friendly feeling when using web-based continuing learning environments, whereas nurses' advanced Internet self-efficacy was the only predictor to explain how they intend to use web-based continuing learning environments more. Copyright © 2010 Elsevier Ltd. All rights reserved.

Development of Variable Camber Continuous Trailing Edge Flap for Performance Adaptive Aeroelastic Wing

NASA Technical Reports Server (NTRS)

Nguyen, Nhan; Kaul, Upender; Lebofsky, Sonia; Ting, Eric; Chaparro, Daniel; Urnes, James

2015-01-01

This paper summarizes the recent development of an adaptive aeroelastic wing shaping control technology called variable camber continuous trailing edge flap (VCCTEF). As wing flexibility increases, aeroelastic interactions with aerodynamic forces and moments become an increasingly important consideration in aircraft design and aerodynamic performance. Furthermore, aeroelastic interactions with flight dynamics can result in issues with vehicle stability and control. The initial VCCTEF concept was developed in 2010 by NASA under a NASA Innovation Fund study entitled "Elastically Shaped Future Air Vehicle Concept," which showed that highly flexible wing aerodynamic surfaces can be elastically shaped in-flight by active control of wing twist and bending deflection in order to optimize the spanwise lift distribution for drag reduction. A collaboration between NASA and Boeing Research & Technology was subsequently funded by NASA from 2012 to 2014 to further develop the VCCTEF concept. This paper summarizes some of the key research areas conducted by NASA during the collaboration with Boeing Research and Technology. These research areas include VCCTEF design concepts, aerodynamic analysis of VCCTEF camber shapes, aerodynamic optimization of lift distribution for drag minimization, wind tunnel test results for cruise and high-lift configurations, flutter analysis and suppression control of flexible wing aircraft, and multi-objective flight control for adaptive aeroelastic wing shaping control.

7 CFR 1980.372 - Protective advances.

Code of Federal Regulations, 2010 CFR

2010-01-01

... or protect the physical security. Attorney fees are not a protective advance. The Lender will not... 7 Agriculture 14 2010-01-01 2009-01-01 true Protective advances. 1980.372 Section 1980.372...) PROGRAM REGULATIONS (CONTINUED) GENERAL Rural Housing Loans § 1980.372 Protective advances. Protective...

Clustering and variable selection in the presence of mixed variable types and missing data.

PubMed

Storlie, C B; Myers, S M; Katusic, S K; Weaver, A L; Voigt, R G; Croarkin, P E; Stoeckel, R E; Port, J D

2018-05-17

We consider the problem of model-based clustering in the presence of many correlated, mixed continuous, and discrete variables, some of which may have missing values. Discrete variables are treated with a latent continuous variable approach, and the Dirichlet process is used to construct a mixture model with an unknown number of components. Variable selection is also performed to identify the variables that are most influential for determining cluster membership. The work is motivated by the need to cluster patients thought to potentially have autism spectrum disorder on the basis of many cognitive and/or behavioral test scores. There are a modest number of patients (486) in the data set along with many (55) test score variables (many of which are discrete valued and/or missing). The goal of the work is to (1) cluster these patients into similar groups to help identify those with similar clinical presentation and (2) identify a sparse subset of tests that inform the clusters in order to eliminate unnecessary testing. The proposed approach compares very favorably with other methods via simulation of problems of this type. The results of the autism spectrum disorder analysis suggested 3 clusters to be most likely, while only 4 test scores had high (>0.5) posterior probability of being informative. This will result in much more efficient and informative testing. The need to cluster observations on the basis of many correlated, continuous/discrete variables with missing values is a common problem in the health sciences as well as in many other disciplines. Copyright © 2018 John Wiley & Sons, Ltd.

Multi-Objective Optimization of a Turbofan for an Advanced, Single-Aisle Transport

NASA Technical Reports Server (NTRS)

Berton, Jeffrey J.; Guynn, Mark D.

2012-01-01

Considerable interest surrounds the design of the next generation of single-aisle commercial transports in the Boeing 737 and Airbus A320 class. Aircraft designers will depend on advanced, next-generation turbofan engines to power these airplanes. The focus of this study is to apply single- and multi-objective optimization algorithms to the conceptual design of ultrahigh bypass turbofan engines for this class of aircraft, using NASA s Subsonic Fixed Wing Project metrics as multidisciplinary objectives for optimization. The independent design variables investigated include three continuous variables: sea level static thrust, wing reference area, and aerodynamic design point fan pressure ratio, and four discrete variables: overall pressure ratio, fan drive system architecture (i.e., direct- or gear-driven), bypass nozzle architecture (i.e., fixed- or variable geometry), and the high- and low-pressure compressor work split. Ramp weight, fuel burn, noise, and emissions are the parameters treated as dependent objective functions. These optimized solutions provide insight to the ultrahigh bypass engine design process and provide information to NASA program management to help guide its technology development efforts.

Discrete factor approximations in simultaneous equation models: estimating the impact of a dummy endogenous variable on a continuous outcome.

PubMed

Mroz, T A

1999-10-01

This paper contains a Monte Carlo evaluation of estimators used to control for endogeneity of dummy explanatory variables in continuous outcome regression models. When the true model has bivariate normal disturbances, estimators using discrete factor approximations compare favorably to efficient estimators in terms of precision and bias; these approximation estimators dominate all the other estimators examined when the disturbances are non-normal. The experiments also indicate that one should liberally add points of support to the discrete factor distribution. The paper concludes with an application of the discrete factor approximation to the estimation of the impact of marriage on wages.

Spool-type control valve assembly with reduced spool stroke for hydraulic belt-and-pulley type continuously variable transmission

DOE Office of Scientific and Technical Information (OSTI.GOV)

Itoh, H.; Akashi, T.; Takada, M.

1987-03-31

This patent describes a hydraulic control system for controlling a speed ratio of a hydraulically-operated continuously variable transmission of belt-and-pulley type having a variable-diameter pulley and a hydraulic cylinder for changing an effective diameter of the variable diameter-pulley of the transmission. The hydraulic control system includes a speed-ratio control valve assembly for controlling the supply and discharge of a pressurized fluid to and from the hydraulic cylinder to thereby change the speed ratio of the transmission. The speed-ratio control valve assembly comprises: a shift-direction switching valve unit disposed in fluid supply and discharge conduits communicating with the hydraulic cylinder, formore » controlling a direction in which the speed ratio of the transmission is varied; a shift-speed control valve unit of spool-valve type connected to the shift-direction switching valve unit. The shift-speed control valve unit is selectively placed in a first state in which the fluid supply and discharge flows to and from the hydraulic cylinder through the conduits are permitted, or in a second state in which the fluid supply flow is restricted while the fluid discharge flow is inhibited; an actuator means for placing the shift speed control valve unit alternately in the first and second states to control a rate of variation in the speed ratio of the transmission in the direction established by the shift-direction switching valve unit.« less

Continued Development of the Rapid Cycle Amine (RCA) System for Advanced Extravehicular Activity Systems

NASA Technical Reports Server (NTRS)

Papale, William; Chullen, Cinda; Campbell, Colin; Conger, Bruce; McMillin, Summer; Jeng, Frank

2014-01-01

Development activities related to the Rapid Cycle Amine (RCA) Carbon Dioxide (CO2) and Humidity control system have progressed to the point of integrating the RCA into an advanced Primary Life Support System (PLSS 2.0) to evaluate the interaction of the RCA among other PLSS components in a ground test environment. The RCA 2.0 assembly (integrated into PLSS 2.0) consists of a valve assembly with commercial actuator motor, a sorbent canister, and a field-programmable gate array (FPGA)-based process node controller. Continued design and development activities for RCA 3.0 have been aimed at optimizing the canister size and incorporating greater fidelity in the valve actuator motor and valve position feedback design. Further, the RCA process node controller is envisioned to incorporate a higher degree of functionality to support a distributed PLSS control architecture. This paper will describe the progression of technology readiness levels of RCA 1.0, 2.0 and 3.0 along with a review of the design and manufacturing successes and challenges for 2.0 and 3.0 units. The anticipated interfaces and interactions with the PLSS 2.0/2.5/3.0 assemblies will also be discussed.

Hydromechanical Advanced Coal Excavator

NASA Technical Reports Server (NTRS)

Estus, Jay M.; Summers, David

1990-01-01

Water-jet cutting reduces coal dust and its hazards. Advanced mining system utilizes full-face, hydromechanical, continuous miner. Coal excavator uses high-pressure water-jet lances, one in each of cutting heads and one in movable lance, to make cuts across top, bottom and middle height, respectively, of coal face. Wedge-shaped cutting heads advance into lower and upper cuts in turn, thereby breaking coal toward middle cut. Thrust cylinders and walking pads advance excavator toward coal face.

Mesoscale Circulation Variability from Five years of Quasi-continuous Glider Observations and Numerical Simulation at a Key Sub-basin 'Choke' Point.

NASA Astrophysics Data System (ADS)

Heslop, E. E.; Mourre, B.; Juza, M.; Troupin, C.; Escudier, R.; Torner, M.; Tintore, J.

2016-02-01

Quasi-continuous glider observations over 5 years have uniquely characterised a high frequency variability in the circulation through the Ibiza Channel, an important `choke' point in the Western Mediterranean Sea. This `choke' point governs the basin/sub-basin scale circulation and the north/south exchanges of different water masses. The resulting multi-scale variability impacts the regional shelf and open ocean ecosystems, including the spawning grounds of Atlantic bluefin tuna. Through the unique glider record we show the relevance of the weekly/mesoscale variability, which is of same order as the previously established seasonal and inter-annual variability. To understand the drivers of this variability we combine the glider data with numerical simulations (WMOP) and altimetry. Two key drivers are identified; extreme winter events, which cause the formation of a cold winter mode water (Winter Intermediate Water) in the shelf areas to the north of the Ibiza Channel, and mesoscale activity, which to the north produce channel `blocking' eddies and to the south intermittent and vigorous flows of fresher `Atlantic' waters through the Ibiza Channel. Results from the 2 km resolution WMOP are compared with the high-resolution (2 - 3 km.) glider data, giving insight into model validation across different scales, for both circulation and water masses. There is an emerging consensus that gliders can uniquely access critical time and length scales and in this study gliders complement existing satellite measurements and models, while opening up new capabilities for multidisciplinary, autonomous and high-resolution ocean observation.

Association of glycaemic variability evaluated by continuous glucose monitoring with diabetic peripheral neuropathy in type 2 diabetic patients.

PubMed

Hu, Yu-Ming; Zhao, Li-Hua; Zhang, Xiu-Lin; Cai, Hong-Li; Huang, Hai-Yan; Xu, Feng; Chen, Tong; Wang, Xue-Qin; Guo, Ai-Song; Li, Jian-An; Su, Jian-Bin

2018-05-01

Diabetic peripheral neuropathy (DPN), a common microvascular complication of diabetes, is linked to glycaemic derangements. Glycaemic variability, as a pattern of glycaemic derangements, is a key risk factor for diabetic complications. We investigated the association of glycaemic variability with DPN in a large-scale sample of type 2 diabetic patients. In this cross-sectional study, we enrolled 982 type 2 diabetic patients who were screened for DPN and monitored by a continuous glucose monitoring (CGM) system between February 2011 and January 2017. Multiple glycaemic variability parameters, including the mean amplitude of glycaemic excursions (MAGE), mean of daily differences (MODD), standard deviation of glucose (SD), and 24-h mean glucose (24-h MG), were calculated from glucose profiles obtained from CGM. Other possible risks for DPN were also examined. Of the recruited type 2 diabetic patients, 20.1% (n = 197) presented with DPN, and these patients also had a higher MAGE, MODD, SD, and 24-h MG than patients without DPN (p < 0.001). Using univariate and multiple logistic regression analyses, MAGE and conventional risks including diabetic duration, HOMA-IR, and hemoglobin A1c (HbA1c) were found to be independent contributors to DPN, and the corresponding odds ratios (95% confidence interval) were 4.57 (3.48-6.01), 1.10 (1.03-1.17), 1.24 (1.09-1.41), and 1.33 (1.15-1.53), respectively. Receiver operating characteristic analysis indicated that the optimal MAGE cutoff value for predicting DPN was 4.60 mmol/L; the corresponding sensitivity was 64.47%, and the specificity was 75.54%. In addition to conventional risks including diabetic duration, HOMA-IR and HbA1c, increased glycaemic variability assessed by MAGE is a significant independent contributor to DPN in type 2 diabetic patients.

Team clinician variability in return-to-play decisions.

PubMed

Shultz, Rebecca; Bido, Jennifer; Shrier, Ian; Meeuwisse, Willem H; Garza, Daniel; Matheson, Gordon O

2013-11-01

To describe the variability in the return-to-play (RTP) decisions of experienced team clinicians and to assess their clinical opinion as to the relevance of 19 factors described in a RTP decision-making model. Survey questionnaire. Advanced Team Physician Course. Sixty-seven of 101 sports medicine clinicians completed the questionnaire. Results were analyzed using descriptive statistics. For categorical variables, we report percentage and frequency. For continuous variables, we report mean (SD) if data were approximately normally distributed and frequencies for clinically relevant categories for skewed data. The average number of years of clinical sports medicine experience was 13.6 (9.8). Of the 62 clinicians who responded fully, 35% (n = 22) would "clear" (vs "not clear") an athlete to participate in sport even if the risk of an acute reinjury or long-term sequelae is increased. When respondents were given 6 different RTP options rather than binary choices, there were increased discrepancies across some injury risk scenarios. For example, 8.1% to 16.1% of respondents who chose to clear an athlete when presented with binary choices, later chose to "not clear" an athlete when given 6 graded RTP options. The respondents often considered factors of potential importance to athletes as nonimportant to the RTP decision process if risk of reinjury was unaffected (range, n = 4 [10%] to n = 19 [45%]). There is a high degree of variability in how different clinicians weight the different factors related to RTP decision making. More precise definitions decrease but do not eliminate this variability.

Number versus Continuous Quantity in Numerosity Judgments by Fish

ERIC Educational Resources Information Center

Agrillo, Christian; Piffer, Laura; Bisazza, Angelo

2011-01-01

In quantity discrimination tasks, adults, infants and animals have been sometimes observed to process number only after all continuous variables, such as area or density, have been controlled for. This has been taken as evidence that processing number may be more cognitively demanding than processing continuous variables. We tested this hypothesis…

2D Flood Modelling Using Advanced Terrain Analysis Techniques And A Fully Continuous DEM-Based Rainfall-Runoff Algorithm

NASA Astrophysics Data System (ADS)

Nardi, F.; Grimaldi, S.; Petroselli, A.

2012-12-01

Remotely sensed Digital Elevation Models (DEMs), largely available at high resolution, and advanced terrain analysis techniques built in Geographic Information Systems (GIS), provide unique opportunities for DEM-based hydrologic and hydraulic modelling in data-scarce river basins paving the way for flood mapping at the global scale. This research is based on the implementation of a fully continuous hydrologic-hydraulic modelling optimized for ungauged basins with limited river flow measurements. The proposed procedure is characterized by a rainfall generator that feeds a continuous rainfall-runoff model producing flow time series that are routed along the channel using a bidimensional hydraulic model for the detailed representation of the inundation process. The main advantage of the proposed approach is the characterization of the entire physical process during hydrologic extreme events of channel runoff generation, propagation, and overland flow within the floodplain domain. This physically-based model neglects the need for synthetic design hyetograph and hydrograph estimation that constitute the main source of subjective analysis and uncertainty of standard methods for flood mapping. Selected case studies show results and performances of the proposed procedure as respect to standard event-based approaches.

Advances in phage display technology for drug discovery.

PubMed

Omidfar, Kobra; Daneshpour, Maryam

2015-06-01

Over the past decade, several library-based methods have been developed to discover ligands with strong binding affinities for their targets. These methods mimic the natural evolution for screening and identifying ligand-target interactions with specific functional properties. Phage display technology is a well-established method that has been applied to many technological challenges including novel drug discovery. This review describes the recent advances in the use of phage display technology for discovering novel bioactive compounds. Furthermore, it discusses the application of this technology to produce proteins and peptides as well as minimize the use of antibodies, such as antigen-binding fragment, single-chain fragment variable or single-domain antibody fragments like VHHs. Advances in screening, manufacturing and humanization technologies demonstrate that phage display derived products can play a significant role in the diagnosis and treatment of disease. The effects of this technology are inevitable in the development pipeline for bringing therapeutics into the market, and this number is expected to rise significantly in the future as new advances continue to take place in display methods. Furthermore, a widespread application of this methodology is predicted in different medical technological areas, including biosensing, monitoring, molecular imaging, gene therapy, vaccine development and nanotechnology.

Deciding in the dark: advance directives and continuation of treatment in chronic critical illness.

PubMed

Camhi, Sharon L; Mercado, Alice F; Morrison, R Sean; Du, Qingling; Platt, David M; August, Gary I; Nelson, Judith E

2009-03-01

Chronic critical illness is a devastating syndrome for which treatment offers limited clinical benefit but imposes heavy burdens on patients, families, clinicians, and the health care system. We studied the availability of advance directives and appropriate surrogates to guide decisions about life-sustaining treatment for the chronically critically ill and the extent and timing of treatment limitation. Prospective cohort study. Respiratory Care Unit (RCU) in a large, tertiary, urban, university-affiliated, hospital. Two hundred three chronically critically ill adults transferred to RCU after tracheotomy for failure to wean from mechanical ventilation in the intensive care unit. None. We interviewed RCU caregivers and reviewed patient records to identify proxy appointments, living wills, or oral statements of treatment preferences, resuscitation directives, and withholding/withdrawal of mechanical ventilation, nutrition, hydration, renal replacement and vasopressors. Forty-three of 203 patients (21.2%) appointed a proxy and 33 (16.2%) expressed preferences in advance directives. Do not resuscitate directives were given for 71 patients (35.0%). Treatment was limited for 39 patients (19.2%). Variables significantly associated with treatment limitation were proxy appointment prior to study entry (time of tracheotomy/RCU transfer) (odds ratio = 6.7, 95% confidence interval [CI], 2.3-20.0, p = 0.0006) and palliative care consultation in the RCU (OR = 40.9, 95% CI, 13.1-127.4, p < 0.0001). Median (interquartile range) time to first treatment limitation was 39 (31.0-45.0) days after hospital admission and 13 (8.0-29.0) days after RCU admission. For patients dying after treatment limitation, median time from first limitation to death ranged from 3 days for mechanical ventilation and hydration to 7 days for renal replacement. Most chronically critically ill patients fail to designate a surrogate decision-maker or express preferences regarding life-sustaining treatments

42 CFR § 414.1410 - Advanced APM determination.

Code of Federal Regulations, 2010 CFR

2017-10-01

... SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) PAYMENT FOR PART B MEDICAL AND OTHER HEALTH SERVICES Merit-Based Incentive Payment System and Alternative Payment Model Incentive § 414.1410 Advanced APM determination. (a) General. An APM is an Advanced APM for a payment year if CMS determines that it meets the...

A systematic review of statistical methods used to test for reliability of medical instruments measuring continuous variables.

PubMed

Zaki, Rafdzah; Bulgiba, Awang; Nordin, Noorhaire; Azina Ismail, Noor

2013-06-01

Reliability measures precision or the extent to which test results can be replicated. This is the first ever systematic review to identify statistical methods used to measure reliability of equipment measuring continuous variables. This studyalso aims to highlight the inappropriate statistical method used in the reliability analysis and its implication in the medical practice. In 2010, five electronic databases were searched between 2007 and 2009 to look for reliability studies. A total of 5,795 titles were initially identified. Only 282 titles were potentially related, and finally 42 fitted the inclusion criteria. The Intra-class Correlation Coefficient (ICC) is the most popular method with 25 (60%) studies having used this method followed by the comparing means (8 or 19%). Out of 25 studies using the ICC, only 7 (28%) reported the confidence intervals and types of ICC used. Most studies (71%) also tested the agreement of instruments. This study finds that the Intra-class Correlation Coefficient is the most popular method used to assess the reliability of medical instruments measuring continuous outcomes. There are also inappropriate applications and interpretations of statistical methods in some studies. It is important for medical researchers to be aware of this issue, and be able to correctly perform analysis in reliability studies.

Modeling the zonal disintegration of rocks near deep level tunnels by gradient internal variable continuous phase transition theory

NASA Astrophysics Data System (ADS)

Haoxiang, Chen; Qi, Chengzhi; Peng, Liu; Kairui, Li; Aifantis, Elias C.

2015-12-01

The occurrence of alternating damage zones surrounding underground openings (commonly known as zonal disintegration) is treated as a "far from thermodynamic equilibrium" dynamical process or a nonlinear continuous phase transition phenomenon. The approach of internal variable gradient theory with diffusive transport, which may be viewed as a subclass of Landau's phase transition theory, is adopted. The order parameter is identified with an irreversible strain quantity, the gradient of which enters into the expression for the free energy of the rock system. The gradient term stabilizes the material behavior in the post-softening regime, where zonal disintegration occurs. The results of a simplified linearized analysis are confirmed by the numerical solution of the nonlinear problem.

Automatic control: the vertebral column of dogfish sharks behaves as a continuously variable transmission with smoothly shifting functions.

PubMed

Porter, Marianne E; Ewoldt, Randy H; Long, John H

2016-09-15

During swimming in dogfish sharks, Squalus acanthias, both the intervertebral joints and the vertebral centra undergo significant strain. To investigate this system, unique among vertebrates, we cyclically bent isolated segments of 10 vertebrae and nine joints. For the first time in the biomechanics of fish vertebral columns, we simultaneously characterized non-linear elasticity and viscosity throughout the bending oscillation, extending recently proposed techniques for large-amplitude oscillatory shear (LAOS) characterization to large-amplitude oscillatory bending (LAOB). The vertebral column segments behave as non-linear viscoelastic springs. Elastic properties dominate for all frequencies and curvatures tested, increasing as either variable increases. Non-linearities within a bending cycle are most in evidence at the highest frequency, 2.0 Hz, and curvature, 5 m -1 Viscous bending properties are greatest at low frequencies and high curvatures, with non-linear effects occurring at all frequencies and curvatures. The range of mechanical behaviors includes that of springs and brakes, with smooth transitions between them that allow for continuously variable power transmission by the vertebral column to assist in the mechanics of undulatory propulsion. © 2016. Published by The Company of Biologists Ltd.

Quantization of Gaussian samples at very low SNR regime in continuous variable QKD applications

NASA Astrophysics Data System (ADS)

Daneshgaran, Fred; Mondin, Marina

2016-09-01

The main problem for information reconciliation in continuous variable Quantum Key Distribution (QKD) at low Signal to Noise Ratio (SNR) is quantization and assignment of labels to the samples of the Gaussian Random Variables (RVs) observed at Alice and Bob. Trouble is that most of the samples, assuming that the Gaussian variable is zero mean which is de-facto the case, tend to have small magnitudes and are easily disturbed by noise. Transmission over longer and longer distances increases the losses corresponding to a lower effective SNR exasperating the problem. This paper looks at the quantization problem of the Gaussian samples at very low SNR regime from an information theoretic point of view. We look at the problem of two bit per sample quantization of the Gaussian RVs at Alice and Bob and derive expressions for the mutual information between the bit strings as a result of this quantization. The quantization threshold for the Most Significant Bit (MSB) should be chosen based on the maximization of the mutual information between the quantized bit strings. Furthermore, while the LSB string at Alice and Bob are balanced in a sense that their entropy is close to maximum, this is not the case for the second most significant bit even under optimal threshold. We show that with two bit quantization at SNR of -3 dB we achieve 75.8% of maximal achievable mutual information between Alice and Bob, hence, as the number of quantization bits increases beyond 2-bits, the number of additional useful bits that can be extracted for secret key generation decreases rapidly. Furthermore, the error rates between the bit strings at Alice and Bob at the same significant bit level are rather high demanding very powerful error correcting codes. While our calculations and simulation shows that the mutual information between the LSB at Alice and Bob is 0.1044 bits, that at the MSB level is only 0.035 bits. Hence, it is only by looking at the bits jointly that we are able to achieve a

Clausal Continuations in Japanese

ERIC Educational Resources Information Center

Krekoski, Ross

2012-01-01

Recent studies illustrate cases of turn continuations that are not necessarily criterially dependent on clausal syntax (Couper-Kuhlen & Ono, 2007; Ford, Fox, & Thompson, 2002), advancing a more multidimensional construal of turn expansions, in general, which, as Auer (2007) put it, "is not a syntactic issue alone" (p. 651). This study further…

Security analysis of orthogonal-frequency-division-multiplexing-based continuous-variable quantum key distribution with imperfect modulation

NASA Astrophysics Data System (ADS)

Zhang, Hang; Mao, Yu; Huang, Duan; Li, Jiawei; Zhang, Ling; Guo, Ying

2018-05-01

We introduce a reliable scheme for continuous-variable quantum key distribution (CV-QKD) by using orthogonal frequency division multiplexing (OFDM). As a spectrally efficient multiplexing technique, OFDM allows a large number of closely spaced orthogonal subcarrier signals used to carry data on several parallel data streams or channels. We place emphasis on modulator impairments which would inevitably arise in the OFDM system and analyze how these impairments affect the OFDM-based CV-QKD system. Moreover, we also evaluate the security in the asymptotic limit and the Pirandola-Laurenza-Ottaviani-Banchi upper bound. Results indicate that although the emergence of imperfect modulation would bring about a slight decrease in the secret key bit rate of each subcarrier, the multiplexing technique combined with CV-QKD results in a desirable improvement on the total secret key bit rate which can raise the numerical value about an order of magnitude.

Entropy generation in Gaussian quantum transformations: applying the replica method to continuous-variable quantum information theory

NASA Astrophysics Data System (ADS)

Gagatsos, Christos N.; Karanikas, Alexandros I.; Kordas, Georgios; Cerf, Nicolas J.

2016-02-01

In spite of their simple description in terms of rotations or symplectic transformations in phase space, quadratic Hamiltonians such as those modelling the most common Gaussian operations on bosonic modes remain poorly understood in terms of entropy production. For instance, determining the quantum entropy generated by a Bogoliubov transformation is notably a hard problem, with generally no known analytical solution, while it is vital to the characterisation of quantum communication via bosonic channels. Here we overcome this difficulty by adapting the replica method, a tool borrowed from statistical physics and quantum field theory. We exhibit a first application of this method to continuous-variable quantum information theory, where it enables accessing entropies in an optical parametric amplifier. As an illustration, we determine the entropy generated by amplifying a binary superposition of the vacuum and a Fock state, which yields a surprisingly simple, yet unknown analytical expression.

Fully Integrated Biochip Platforms for Advanced Healthcare

PubMed Central

Carrara, Sandro; Ghoreishizadeh, Sara; Olivo, Jacopo; Taurino, Irene; Baj-Rossi, Camilla; Cavallini, Andrea; de Beeck, Maaike Op; Dehollain, Catherine; Burleson, Wayne; Moussy, Francis Gabriel; Guiseppi-Elie, Anthony; De Micheli, Giovanni

2012-01-01

Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications. PMID:23112644

Advanced nursing practice.

PubMed

Carroll, Mark

Mark Carroll examines the concept of advanced nursing practice and highlights a number of the difficulties in assessing and defining different levels of practice. Some of the differences and similarities between advanced practice in the US and UK are compared and contrasted. Issues of élitism and the lack of correlation between the needs of the healthcare system and professional self-interest prevent the advancement of specialist roles in the UK. The continuing focus of local trusts on the medicalisation of roles to meet the demands of the healthcare system appears to ignore the need for nursing to expand from within the profession.

The Role of Colleges of Advanced Education in the Education of Adults. A Report to the Australian Commission on Advanced Education.

ERIC Educational Resources Information Center

Nelson, A. J. A.

This report to the Australian Commission on Advanced Education is intended as a basis for discussion by those who have the responsibility for making program and policy decisions in continuing education in Australia's colleges of advanced education. Though the idea that education is continuous with life is coming to be widely accepted…

Fuel economy effects and incremental cost, weight and leadtime impacts of employing a continuously variable transmission (CVT) in mid-size passenger cars or compact light trucks

DOT National Transportation Integrated Search

1999-06-01

This report is a paper study of the fuel economy benefits on the Environmental Protection Agency (EPA) City and Highway Cycles of using a continuously variable transmission (CVT) in a 3625 lb (1644 kg) car and compact light truck. The baseline vehicl...

High key rate continuous-variable quantum key distribution with a real local oscillator.

PubMed

Wang, Tao; Huang, Peng; Zhou, Yingming; Liu, Weiqi; Ma, Hongxin; Wang, Shiyu; Zeng, Guihua

2018-02-05

Continuous-variable quantum key distribution (CVQKD) with a real local oscillator (LO) has been extensively studied recently due to its security and simplicity. In this paper, we propose a novel implementation of a high-key-rate CVQKD with a real LO. Particularly, with the help of the simultaneously generated reference pulse, the phase drift of the signal is tracked in real time and then compensated. By utilizing the time and polarization multiplexing techniques to isolate the reference pulse and controlling the intensity of it, not only the contamination from it is suppressed, but also a high accuracy of the phase compensation can be guaranteed. Besides, we employ homodyne detection on the signal to ensure the high quantum efficiency and heterodyne detection on the reference pulse to acquire the complete phase information of it. In order to suppress the excess noise, a theoretical noise model for our scheme is established. According to this model, the impact of the modulation variance and the intensity of the reference pulse are both analysed theoretically and then optimized according to the experimental data. By measuring the excess noise in the 25km optical fiber transmission system, a 3.14Mbps key rate in the asymptotic regime proves to be achievable. This work verifies the feasibility of the high-key-rate CVQKD with a real LO within the metropolitan area.

Inter-subject variability modulates phonological advance planning in the production of adjective-noun phrases.

PubMed

Michel Lange, Violaine; Laganaro, Marina

2014-01-01

The literature on advance phonological planning in adjective-noun phrases (NPs) presents diverging results: while many experimental studies suggest that the entire NP is encoded before articulation, other results favor a span of encoding limited to the first word. Although cross-linguistic differences in the structure of adjective-NPs may account for some of these contrasting results, divergences have been reported even among similar languages and syntactic structures. Here we examined whether inter-individual differences account for variability in the span of phonological planning in the production of French NPs, where previous results indicated encoding limited to the first word. The span of phonological encoding is tested with the picture-word interference (PWI) paradigm using phonological distractors related to the noun or to the adjective of the NPs. In Experiment 1, phonological priming effects were limited to the first word in adjective NPs whichever the position of the adjective (pre-nominal or post-nominal). Crucially, phonological priming effects on the second word interacted with speakers' production speed suggesting different encoding strategies for participants. In Experiment 2, we tested this hypothesis further with a larger group of participants. Results clearly showed that slow and fast initializing participants presented different phonological priming patterns on the last element of adjective-NPs: while the first word was primed by a distractor for all speakers, only the slow speaker group presented a priming effect on the second element of the NP. These results show that the span of phonological encoding is modulated by inter-individual strategies: in experimental paradigms some speakers plan word by word whereas others encode beyond the initial word. We suggest that the diverging results reported in the literature on advance phonological planning may partly be reconciled in light of the present results.

Variability of a "force signature" during windmill softball pitching and relationship between discrete force variables and pitch velocity.

PubMed

Nimphius, Sophia; McGuigan, Michael R; Suchomel, Timothy J; Newton, Robert U

2016-06-01

This study assessed reliability of discrete ground reaction force (GRF) variables over multiple pitching trials, investigated the relationships between discrete GRF variables and pitch velocity (PV) and assessed the variability of the "force signature" or continuous force-time curve during the pitching motion of windmill softball pitchers. Intraclass correlation coefficient (ICC) for all discrete variables was high (0.86-0.99) while the coefficient of variance (CV) was low (1.4-5.2%). Two discrete variables were significantly correlated to PV; second vertical peak force (r(5)=0.81, p=0.03) and time between peak forces (r(5)=-0.79; p=0.03). High ICCs and low CVs support the reliability of discrete GRF and PV variables over multiple trials and significant correlations indicate there is a relationship between the ability to produce force and the timing of this force production with PV. The mean of all pitchers' curve-average standard deviation of their continuous force-time curves demonstrated low variability (CV=4.4%) indicating a repeatable and identifiable "force signature" pattern during this motion. As such, the continuous force-time curve in addition to discrete GRF variables should be examined in future research as a potential method to monitor or explain changes in pitching performance. Copyright © 2016 Elsevier B.V. All rights reserved.

Multiplicative Forests for Continuous-Time Processes.

PubMed

Weiss, Jeremy C; Natarajan, Sriraam; Page, David

2012-01-01

Learning temporal dependencies between variables over continuous time is an important and challenging task. Continuous-time Bayesian networks effectively model such processes but are limited by the number of conditional intensity matrices, which grows exponentially in the number of parents per variable. We develop a partition-based representation using regression trees and forests whose parameter spaces grow linearly in the number of node splits. Using a multiplicative assumption we show how to update the forest likelihood in closed form, producing efficient model updates. Our results show multiplicative forests can be learned from few temporal trajectories with large gains in performance and scalability.

Continuous Dropout.

PubMed

Shen, Xu; Tian, Xinmei; Liu, Tongliang; Xu, Fang; Tao, Dacheng

2017-10-03

Dropout has been proven to be an effective algorithm for training robust deep networks because of its ability to prevent overfitting by avoiding the co-adaptation of feature detectors. Current explanations of dropout include bagging, naive Bayes, regularization, and sex in evolution. According to the activation patterns of neurons in the human brain, when faced with different situations, the firing rates of neurons are random and continuous, not binary as current dropout does. Inspired by this phenomenon, we extend the traditional binary dropout to continuous dropout. On the one hand, continuous dropout is considerably closer to the activation characteristics of neurons in the human brain than traditional binary dropout. On the other hand, we demonstrate that continuous dropout has the property of avoiding the co-adaptation of feature detectors, which suggests that we can extract more independent feature detectors for model averaging in the test stage. We introduce the proposed continuous dropout to a feedforward neural network and comprehensively compare it with binary dropout, adaptive dropout, and DropConnect on Modified National Institute of Standards and Technology, Canadian Institute for Advanced Research-10, Street View House Numbers, NORB, and ImageNet large scale visual recognition competition-12. Thorough experiments demonstrate that our method performs better in preventing the co-adaptation of feature detectors and improves test performance.

SSAGES: Software Suite for Advanced General Ensemble Simulations.

PubMed

Sidky, Hythem; Colón, Yamil J; Helfferich, Julian; Sikora, Benjamin J; Bezik, Cody; Chu, Weiwei; Giberti, Federico; Guo, Ashley Z; Jiang, Xikai; Lequieu, Joshua; Li, Jiyuan; Moller, Joshua; Quevillon, Michael J; Rahimi, Mohammad; Ramezani-Dakhel, Hadi; Rathee, Vikramjit S; Reid, Daniel R; Sevgen, Emre; Thapar, Vikram; Webb, Michael A; Whitmer, Jonathan K; de Pablo, Juan J

2018-01-28

Molecular simulation has emerged as an essential tool for modern-day research, but obtaining proper results and making reliable conclusions from simulations requires adequate sampling of the system under consideration. To this end, a variety of methods exist in the literature that can enhance sampling considerably, and increasingly sophisticated, effective algorithms continue to be developed at a rapid pace. Implementation of these techniques, however, can be challenging for experts and non-experts alike. There is a clear need for software that provides rapid, reliable, and easy access to a wide range of advanced sampling methods and that facilitates implementation of new techniques as they emerge. Here we present SSAGES, a publicly available Software Suite for Advanced General Ensemble Simulations designed to interface with multiple widely used molecular dynamics simulations packages. SSAGES allows facile application of a variety of enhanced sampling techniques-including adaptive biasing force, string methods, and forward flux sampling-that extract meaningful free energy and transition path data from all-atom and coarse-grained simulations. A noteworthy feature of SSAGES is a user-friendly framework that facilitates further development and implementation of new methods and collective variables. In this work, the use of SSAGES is illustrated in the context of simple representative applications involving distinct methods and different collective variables that are available in the current release of the suite. The code may be found at: https://github.com/MICCoM/SSAGES-public.

SSAGES: Software Suite for Advanced General Ensemble Simulations

NASA Astrophysics Data System (ADS)

Sidky, Hythem; Colón, Yamil J.; Helfferich, Julian; Sikora, Benjamin J.; Bezik, Cody; Chu, Weiwei; Giberti, Federico; Guo, Ashley Z.; Jiang, Xikai; Lequieu, Joshua; Li, Jiyuan; Moller, Joshua; Quevillon, Michael J.; Rahimi, Mohammad; Ramezani-Dakhel, Hadi; Rathee, Vikramjit S.; Reid, Daniel R.; Sevgen, Emre; Thapar, Vikram; Webb, Michael A.; Whitmer, Jonathan K.; de Pablo, Juan J.

2018-01-01

Molecular simulation has emerged as an essential tool for modern-day research, but obtaining proper results and making reliable conclusions from simulations requires adequate sampling of the system under consideration. To this end, a variety of methods exist in the literature that can enhance sampling considerably, and increasingly sophisticated, effective algorithms continue to be developed at a rapid pace. Implementation of these techniques, however, can be challenging for experts and non-experts alike. There is a clear need for software that provides rapid, reliable, and easy access to a wide range of advanced sampling methods and that facilitates implementation of new techniques as they emerge. Here we present SSAGES, a publicly available Software Suite for Advanced General Ensemble Simulations designed to interface with multiple widely used molecular dynamics simulations packages. SSAGES allows facile application of a variety of enhanced sampling techniques—including adaptive biasing force, string methods, and forward flux sampling—that extract meaningful free energy and transition path data from all-atom and coarse-grained simulations. A noteworthy feature of SSAGES is a user-friendly framework that facilitates further development and implementation of new methods and collective variables. In this work, the use of SSAGES is illustrated in the context of simple representative applications involving distinct methods and different collective variables that are available in the current release of the suite. The code may be found at: https://github.com/MICCoM/SSAGES-public.

Generating the local oscillator "locally" in continuous-variable quantum key distribution based on coherent detection

DOE PAGES

Qi, Bing; Lougovski, Pavel; Pooser, Raphael C.; ...

2015-10-21

Continuous-variable quantum key distribution (CV-QKD) protocols based on coherent detection have been studied extensively in both theory and experiment. In all the existing implementations of CV-QKD, both the quantum signal and the local oscillator (LO) are generated from the same laser and propagate through the insecure quantum channel. This arrangement may open security loopholes and limit the potential applications of CV-QKD. In our paper, we propose and demonstrate a pilot-aided feedforward data recovery scheme that enables reliable coherent detection using a “locally” generated LO. Using two independent commercial laser sources and a spool of 25-km optical fiber, we construct amore » coherent communication system. The variance of the phase noise introduced by the proposed scheme is measured to be 0.04 (rad 2), which is small enough to enable secure key distribution. This technology opens the door for other quantum communication protocols, such as the recently proposed measurement-device-independent CV-QKD, where independent light sources are employed by different users.« less

Secondary School Advanced Mathematics, Chapter 6, The Complex Number System, Chapter 7, Equations of the First and Second Degree in Two Variables. Student's Text.

ERIC Educational Resources Information Center

Stanford Univ., CA. School Mathematics Study Group.

This text is the fourth of five in the Secondary School Advanced Mathematics (SSAM) series which was designed to meet the needs of students who have completed the Secondary School Mathematics (SSM) program, and wish to continue their study of mathematics. This text begins with a brief discussion of quadratic equations which motivates the…

Secondary School Advanced Mathematics, Chapter 6, The Complex Number System, Chapter 7, Equations of the First and Second Degree in Two Variables. Teacher's Commentary.

ERIC Educational Resources Information Center

Stanford Univ., CA. School Mathematics Study Group.

This manual was designed for use with the fourth of five texts in the Secondary School Advanced Mathematics (SSAM) series. Developed for students who have completed the Secondary School Mathematics (SSM) program and wish to continue their studies in mathematics, this series is designed to review, strengthen, and fill gaps in the material covered…

The clinical impact of continuing to prescribe antiretroviral therapy in patients with advanced AIDS who manifest no virologic or immunologic benefit.

PubMed

Wohl, David A; Kendall, Michelle A; Feinberg, Judith; Alston-Smith, Beverly; Owens, Susan; Chafey, Suzette; Marco, Michael; Maxwell, Sharon; Benson, Constance; Keiser, Philip; van der Horst, Charles; Jacobson, Mark A

2013-01-01

Despite the efficacy and tolerability of modern antiretroviral therapy (ART), many patients with advanced AIDS prescribed these regimens do not achieve viral suppression or immune reconstitution as a result of poor adherence, drug resistance, or both. The clinical outcomes of continued ART prescription for such patients have not been well characterized. We examined the causes and predictors of all-cause mortality, AIDS-defining conditions, and serious non-AIDS-defining events among a cohort of participants in a clinical trial of pre-emptive therapy for CMV disease. We focused on participants who, despite ART had failed to achieve virologic suppression and substantive immune reconstitution. 233 ART-receiving participants entered with a median baseline CD4+ T cell count of 30/mm(3) and plasma HIV RNA of 5 log10 copies/mL. During a median 96 weeks of follow-up, 24.0% died (a mortality rate of 10.7/100 patient-years); 27.5% reported a new AIDS-defining condition, and 22.3% a new serious non-AIDS event. Of the deaths, 42.8% were due to an AIDS-defining condition, 44.6% were due to a non-AIDS-defining condition, and 12.5% were of unknown etiology. Decreased risk of mortality was associated with baseline CD4+ T cell count ≥25/mm(3) and lower baseline HIV RNA. Among patients with advanced AIDS prescribed modern ART who achieve neither virologic suppression nor immune reconstitution, crude mortality percentages appear to be lower than reported in cohorts of patients studied a decade earlier. Also, in contrast to the era before modern ART became available, nearly half of the deaths in our modern-era study were caused by serious non-AIDS-defining events. Even among the most advanced AIDS patients who were not obtaining apparent immunologic and virologic benefit from ART, continued prescription of these medications appears to alter the natural history of AIDS--improving survival and shifting the causes of death from AIDS- to non-AIDS-defining conditions.

10 CFR 611.3 - Advanced technology vehicle.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Advanced technology vehicle. 611.3 Section 611.3 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS ADVANCED TECHNOLOGY VEHICLES MANUFACTURER ASSISTANCE PROGRAM General § 611.3 Advanced technology vehicle. In order to demonstrate that a vehicle is an...

10 CFR 611.3 - Advanced technology vehicle.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Advanced technology vehicle. 611.3 Section 611.3 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS ADVANCED TECHNOLOGY VEHICLES MANUFACTURER ASSISTANCE PROGRAM General § 611.3 Advanced technology vehicle. In order to demonstrate that a vehicle is an...

10 CFR 611.3 - Advanced technology vehicle.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Advanced technology vehicle. 611.3 Section 611.3 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS ADVANCED TECHNOLOGY VEHICLES MANUFACTURER ASSISTANCE PROGRAM General § 611.3 Advanced technology vehicle. In order to demonstrate that a vehicle is an...

10 CFR 611.3 - Advanced technology vehicle.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Advanced technology vehicle. 611.3 Section 611.3 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS ADVANCED TECHNOLOGY VEHICLES MANUFACTURER ASSISTANCE PROGRAM General § 611.3 Advanced technology vehicle. In order to demonstrate that a vehicle is an...

10 CFR 611.3 - Advanced technology vehicle.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Advanced technology vehicle. 611.3 Section 611.3 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS ADVANCED TECHNOLOGY VEHICLES MANUFACTURER ASSISTANCE PROGRAM General § 611.3 Advanced technology vehicle. In order to demonstrate that a vehicle is an...

Kilovoltage energy imaging with a radiotherapy linac with a continuously variable energy range.

PubMed

Roberts, D A; Hansen, V N; Thompson, M G; Poludniowski, G; Niven, A; Seco, J; Evans, P M

2012-03-01

In this paper, the effect on image quality of significantly reducing the primary electron energy of a radiotherapy accelerator is investigated using a novel waveguide test piece. The waveguide contains a novel variable coupling device (rotovane), allowing for a wide continuously variable energy range of between 1.4 and 9 MeV suitable for both imaging and therapy. Imaging at linac accelerating potentials close to 1 MV was investigated experimentally and via Monte Carlo simulations. An imaging beam line was designed, and planar and cone beam computed tomography images were obtained to enable qualitative and quantitative comparisons with kilovoltage and megavoltage imaging systems. The imaging beam had an electron energy of 1.4 MeV, which was incident on a water cooled electron window consisting of stainless steel, a 5 mm carbon electron absorber and 2.5 mm aluminium filtration. Images were acquired with an amorphous silicon detector sensitive to diagnostic x-ray energies. The x-ray beam had an average energy of 220 keV and half value layer of 5.9 mm of copper. Cone beam CT images with the same contrast to noise ratio as a gantry mounted kilovoltage imaging system were obtained with doses as low as 2 cGy. This dose is equivalent to a single 6 MV portal image. While 12 times higher than a 100 kVp CBCT system (Elekta XVI), this dose is 140 times lower than a 6 MV cone beam imaging system and 6 times lower than previously published LowZ imaging beams operating at higher (4-5 MeV) energies. The novel coupling device provides for a wide range of electron energies that are suitable for kilovoltage quality imaging and therapy. The imaging system provides high contrast images from the therapy portal at low dose, approaching that of gantry mounted kilovoltage x-ray systems. Additionally, the system provides low dose imaging directly from the therapy portal, potentially allowing for target tracking during radiotherapy treatment. There is the scope with such a tuneable system

Effects of process variables and kinetics on the degradation of 2,4-dichlorophenol using advanced reduction processes (ARP).

PubMed

Yu, Xingyue; Cabooter, Deirdre; Dewil, Raf

2018-05-24

This study aims at investigating the efficiency and kinetics of 2,4-DCP degradation via advanced reduction processes (ARP). Using UV light as activation method, the highest degradation efficiency of 2,4-DCP was obtained when using sulphite as a reducing agent. The highest degradation efficiency was observed under alkaline conditions (pH = 10.0), for high sulphite dosage and UV intensity, and low 2,4-DCP concentration. For all process conditions, first-order reaction rate kinetics were applicable. A quadratic polynomial equation fitted by a Box-Behnken Design was used as a statistical model and proved to be precise and reliable in describing the significance of the different process variables. The analysis of variance demonstrated that the experimental results were in good agreement with the predicted model (R 2  = 0.9343), and solution pH, sulphite dose and UV intensity were found to be key process variables in the sulphite/UV ARP. Consequently, the present study provides a promising approach for the efficient degradation of 2,4-DCP with fast degradation kinetics. Copyright © 2018 Elsevier B.V. All rights reserved.

Competitive Strategy in Continuing Education.

ERIC Educational Resources Information Center

Baden, Clifford

1987-01-01

Reviews strategic variables available to those planning continuing education marketing programs. Discusses generic competitive strategies: (1) overall cost leadership, (2) differentiation, and (3) specialization. Mentions several potential problems. (CH)

Properties of Rolled AZ31 Magnesium Alloy Sheet Fabricated by Continuous Variable Cross-Section Direct Extrusion

NASA Astrophysics Data System (ADS)

Liu, Yang; Li, Feng; Li, Xue Wen; Shi, Wen Yong

2018-03-01

Rolling is currently a widely used method for manufacturing and processing high-performance magnesium alloy sheets and has received widespread attention in recent years. Here, we combined continuous variable cross-section direct extrusion (CVCDE) and rolling processes. The microstructure and mechanical properties of the resulting sheets rolled at different temperatures from CVCDE extrudate were investigated by optical microscopy, scanning electron microscope, transmission electron microscopy and electron backscatter diffraction. The results showed that a fine-grained microstructure was present with an average grain size of 3.62 μm in sheets rolled from CVCDE extrudate at 623 K. Dynamic recrystallization and a large strain were induced by the multi-pass rolling, which resulted in grain refinement. In the 573-673 K range, the yield strength, tensile strength and elongation initially increased and then declined as the CVCDE temperature increased. The above results provide an important scientific basis of processing, manufacturing and the active control on microstructure and property for high-performance magnesium alloy sheet.

Distribution of continuous variable quantum entanglement at a telecommunication wavelength over 20  km of optical fiber.

PubMed

Feng, Jinxia; Wan, Zhenju; Li, Yuanji; Zhang, Kuanshou

2017-09-01

The distribution of continuous variable (CV) Einstein-Podolsky-Rosen (EPR)-entangled beams at a telecommunication wavelength of 1550 nm over single-mode fibers is investigated. EPR-entangled beams with quantum entanglement of 8.3 dB are generated using a single nondegenerate optical parametric amplifier based on a type-II periodically poled KTiOPO 4 crystal. When one beam of the generated EPR-entangled beams is distributed over 20 km of single-mode fiber, 1.02 dB quantum entanglement can still be measured. The degradation of CV quantum entanglement in a noisy fiber channel is theoretically analyzed considering the effect of depolarized guided acoustic wave Brillouin scattering in optical fibers. The theoretical prediction is in good agreement with the experimental results.

CCM Continuity Constraint Method: A finite-element computational fluid dynamics algorithm for incompressible Navier-Stokes fluid flows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, P. T.

1993-09-01

As the field of computational fluid dynamics (CFD) continues to mature, algorithms are required to exploit the most recent advances in approximation theory, numerical mathematics, computing architectures, and hardware. Meeting this requirement is particularly challenging in incompressible fluid mechanics, where primitive-variable CFD formulations that are robust, while also accurate and efficient in three dimensions, remain an elusive goal. This dissertation asserts that one key to accomplishing this goal is recognition of the dual role assumed by the pressure, i.e., a mechanism for instantaneously enforcing conservation of mass and a force in the mechanical balance law for conservation of momentum. Provingmore » this assertion has motivated the development of a new, primitive-variable, incompressible, CFD algorithm called the Continuity Constraint Method (CCM). The theoretical basis for the CCM consists of a finite-element spatial semi-discretization of a Galerkin weak statement, equal-order interpolation for all state-variables, a 0-implicit time-integration scheme, and a quasi-Newton iterative procedure extended by a Taylor Weak Statement (TWS) formulation for dispersion error control. Original contributions to algorithmic theory include: (a) formulation of the unsteady evolution of the divergence error, (b) investigation of the role of non-smoothness in the discretized continuity-constraint function, (c) development of a uniformly H 1 Galerkin weak statement for the Reynolds-averaged Navier-Stokes pressure Poisson equation, (d) derivation of physically and numerically well-posed boundary conditions, and (e) investigation of sparse data structures and iterative methods for solving the matrix algebra statements generated by the algorithm.« less

Secret information reconciliation based on punctured low-density parity-check codes for continuous-variable quantum key distribution

NASA Astrophysics Data System (ADS)

Jiang, Xue-Qin; Huang, Peng; Huang, Duan; Lin, Dakai; Zeng, Guihua

2017-02-01

Achieving information theoretic security with practical complexity is of great interest to continuous-variable quantum key distribution in the postprocessing procedure. In this paper, we propose a reconciliation scheme based on the punctured low-density parity-check (LDPC) codes. Compared to the well-known multidimensional reconciliation scheme, the present scheme has lower time complexity. Especially when the chosen punctured LDPC code achieves the Shannon capacity, the proposed reconciliation scheme can remove the information that has been leaked to an eavesdropper in the quantum transmission phase. Therefore, there is no information leaked to the eavesdropper after the reconciliation stage. This indicates that the privacy amplification algorithm of the postprocessing procedure is no more needed after the reconciliation process. These features lead to a higher secret key rate, optimal performance, and availability for the involved quantum key distribution scheme.

Burn injury pain: the continuing challenge.

PubMed

Summer, Gretchen J; Puntillo, Kathleen A; Miaskowski, Christine; Green, Paul G; Levine, Jon D

2007-07-01

The development of more effective methods of relieving pain associated with burn injury is a major unmet medical need. Not only is acute burn injury pain a source of immense suffering, but it has been linked to debilitating chronic pain and stress-related disorders. Although pain management guidelines and protocols have been developed and implemented, unrelieved moderate-to-severe pain continues to be reported after burn injury. One reason for this is that the intensity of pain associated with wound care and rehabilitation therapy, the major source of severe pain in this patient population, varies widely over the 3 phases of burn recovery, making it difficult to estimate analgesic requirements. The effects of opioids, the most commonly administered analgesics for burn injury procedural pain, are difficult to gauge over the course of burn recovery because the need for an opioid may change rapidly, resulting in the overmedication or undermedication of burn-injured patients. Understanding the mechanisms that contribute to the intensity and variability of burn injury pain over time is crucial to its proper management. We provide an overview of the types of pain associated with a burn injury, describe how these different types of pain interfere with the phases of burn recovery, and summarize pharmacologic pain management strategies across the continuum of burn care. We conclude with a discussion and suggestions for improvement. Rational management, based on the underlying mechanisms that contribute to the intensity and variability of burn injury pain, is in its infancy. The paucity of information highlights the need for research that explores and advances the identification of mechanisms of acute and chronic burn injury pain. Researchers continue to report that burn pain is undertreated. This review examines burn injury pain management across the phases of burn recovery, emphasizing 3 types of pain that require separate assessment and management. It provides insights

Enhanced Requirements for Assessment in a Competency-Based, Time-Variable Medical Education System.

PubMed

Gruppen, Larry D; Ten Cate, Olle; Lingard, Lorelei A; Teunissen, Pim W; Kogan, Jennifer R

2018-03-01

Competency-based, time-variable medical education has reshaped the perceptions and practices of teachers, curriculum designers, faculty developers, clinician educators, and program administrators. This increasingly popular approach highlights the fact that learning among different individuals varies in duration, foundation, and goal. Time variability places particular demands on the assessment data that are so necessary for making decisions about learner progress. These decisions may be formative (e.g., feedback for improvement) or summative (e.g., decisions about advancing a student). This article identifies challenges to collecting assessment data and to making assessment decisions in a time-variable system. These challenges include managing assessment data, defining and making valid assessment decisions, innovating in assessment, and modeling the considerable complexity of assessment in real-world settings and richly interconnected social systems. There are hopeful signs of creativity in assessment both from researchers and practitioners, but the transition from a traditional to a competency-based medical education system will likely continue to create much controversy and offer opportunities for originality and innovation in assessment.

Great Expectations in the Joint Advanced Manufacturing Region

DTIC Science & Technology

2016-12-01

would be continuous experimentation and risk reduction prototyping. The entire manufacturing life cycle— design , testing, product development...on the back of a napkin, they decided to call their effort the Joint Advanced Manufacturing Region (JAMR) and manage it as an Integrated Product ... designed to support the continuous experimentation of advanced manufacturing tactics, tech- niques and procedures under actual operational or combat

Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial

PubMed Central

Adams, Richard A; Meade, Angela M; Seymour, Matthew T; Wilson, Richard H; Madi, Ayman; Fisher, David; Kenny, Sarah L; Kay, Edward; Hodgkinson, Elizabeth; Pope, Malcolm; Rogers, Penny; Wasan, Harpreet; Falk, Stephen; Gollins, Simon; Hickish, Tamas; Bessell, Eric M; Propper, David; Kennedy, M John; Kaplan, Richard; Maughan, Timothy S

2011-01-01

Summary Background When cure is impossible, cancer treatment should focus on both length and quality of life. Maximisation of time without toxic effects could be one effective strategy to achieve both of these goals. The COIN trial assessed preplanned treatment holidays in advanced colorectal cancer to achieve this aim. Methods COIN was a randomised controlled trial in patients with previously untreated advanced colorectal cancer. Patients received either continuous oxaliplatin and fluoropyrimidine combination (arm A), continuous chemotherapy plus cetuximab (arm B), or intermittent (arm C) chemotherapy. In arms A and B, treatment continued until development of progressive disease, cumulative toxic effects, or the patient chose to stop. In arm C, patients who had not progressed at their 12-week scan started a chemotherapy-free interval until evidence of disease progression, when the same treatment was restarted. Randomisation was done centrally (via telephone) by the MRC Clinical Trials Unit using minimisation. Treatment allocation was not masked. The comparison of arms A and B is described in a companion paper. Here, we compare arms A and C, with the primary objective of establishing whether overall survival on intermittent therapy was non-inferior to that on continuous therapy, with a predefined non-inferiority boundary of 1·162. Intention-to-treat (ITT) and per-protocol analyses were done. This trial is registered, ISRCTN27286448. Findings 1630 patients were randomly assigned to treatment groups (815 to continuous and 815 to intermittent therapy). Median survival in the ITT population (n=815 in both groups) was 15·8 months (IQR 9·4–26·1) in arm A and 14·4 months (8·0–24·7) in arm C (hazard ratio [HR] 1·084, 80% CI 1·008–1·165). In the per-protocol population (arm A, n=467; arm C, n=511), median survival was 19·6 months (13·0–28·1) in arm A and 18·0 months (12·1–29·3) in arm C (HR 1·087, 0·986–1·198). The upper limits of CIs for HRs

Entanglement enhancement through multirail noise reduction for continuous-variable measurement-based quantum-information processing

NASA Astrophysics Data System (ADS)

Su, Yung-Chao; Wu, Shin-Tza

2017-09-01

We study theoretically the teleportation of a controlled-phase (cz) gate through measurement-based quantum-information processing for continuous-variable systems. We examine the degree of entanglement in the output modes of the teleported cz-gate for two classes of resource states: the canonical cluster states that are constructed via direct implementations of two-mode squeezing operations and the linear-optical version of cluster states which are built from linear-optical networks of beam splitters and phase shifters. In order to reduce the excess noise arising from finite-squeezed resource states, teleportation through resource states with different multirail designs will be considered and the enhancement of entanglement in the teleported cz gates will be analyzed. For multirail cluster with an arbitrary number of rails, we obtain analytical expressions for the entanglement in the output modes and analyze in detail the results for both classes of resource states. At the same time, we also show that for uniformly squeezed clusters the multirail noise reduction can be optimized when the excess noise is allocated uniformly to the rails. To facilitate the analysis, we develop a trick with manipulations of quadrature operators that can reveal rather efficiently the measurement sequence and corrective operations needed for the measurement-based gate teleportation, which will also be explained in detail.

Selective spectroscopic imaging of hyperpolarized pyruvate and its metabolites using a single-echo variable phase advance method in balanced SSFP

PubMed Central

Varma, Gopal; Wang, Xiaoen; Vinogradov, Elena; Bhatt, Rupal S.; Sukhatme, Vikas; Seth, Pankaj; Lenkinski, Robert E.; Alsop, David C.; Grant, Aaron K.

2015-01-01

Purpose In balanced steady state free precession (bSSFP), the signal intensity has a well-known dependence on the off-resonance frequency, or, equivalently, the phase advance between successive radiofrequency (RF) pulses. The signal profile can be used to resolve the contributions from the spectrally separated metabolites. This work describes a method based on use of a variable RF phase advance to acquire spatial and spectral data in a time-efficient manner for hyperpolarized 13C MRI. Theory and Methods The technique relies on the frequency response from a bSSFP acquisition to acquire relatively rapid, high-resolution images that may be reconstructed to separate contributions from different metabolites. The ability to produce images from spectrally separated metabolites was demonstrated in-vitro, as well as in-vivo following administration of hyperpolarized 1-13C pyruvate in mice with xenograft tumors. Results In-vivo images of pyruvate, alanine, pyruvate hydrate and lactate were reconstructed from 4 images acquired in 2 seconds with an in-plane resolution of 1.25 × 1.25mm2 and 5mm slice thickness. Conclusions The phase advance method allowed acquisition of spectroscopically selective images with high spatial and temporal resolution. This method provides an alternative approach to hyperpolarized 13C spectroscopic MRI that can be combined with other techniques such as multi-echo or fluctuating equilibrium bSSFP. PMID:26507361

Advanced space propulsion concepts

NASA Technical Reports Server (NTRS)

Lapointe, Michael R.

1993-01-01

The NASA Lewis Research Center has been actively involved in the evaluation and development of advanced spacecraft propulsion. Recent program elements have included high energy density propellants, electrode less plasma thruster concepts, and low power laser propulsion technology. A robust advanced technology program is necessary to develop new, cost-effective methods of spacecraft propulsion, and to continue to push the boundaries of human knowledge and technology.

Multiplicative Forests for Continuous-Time Processes

PubMed Central

Weiss, Jeremy C.; Natarajan, Sriraam; Page, David

2013-01-01

Learning temporal dependencies between variables over continuous time is an important and challenging task. Continuous-time Bayesian networks effectively model such processes but are limited by the number of conditional intensity matrices, which grows exponentially in the number of parents per variable. We develop a partition-based representation using regression trees and forests whose parameter spaces grow linearly in the number of node splits. Using a multiplicative assumption we show how to update the forest likelihood in closed form, producing efficient model updates. Our results show multiplicative forests can be learned from few temporal trajectories with large gains in performance and scalability. PMID:25284967

Cataclysmic Variable Stars

NASA Astrophysics Data System (ADS)

Hellier, Coel

2001-01-01

Cataclysmic variable stars are the most variable stars in the night sky, fluctuating in brightness continually on timescales from seconds to hours to weeks to years. The changes can be recorded using amateur telescopes, yet are also the subject of intensive study by professional astronomers. That study has led to an understanding of cataclysmic variables as binary stars, orbiting so closely that material transfers from one star to the other. The resulting process of accretion is one of the most important in astrophysics. This book presents the first account of cataclysmic variables at an introductory level. Assuming no previous knowledge of the field, it explains the basic principles underlying the variability, while providing an extensive compilation of cataclysmic variable light curves. Aimed at amateur astronomers, undergraduates, and researchers, the main text is accessible to those with no mathematical background, while supplementary boxes present technical details and equations.

Detection of quantum steering in multipartite continuous-variable Greenberger-Horne-Zeilinger-like states

NASA Astrophysics Data System (ADS)

Wang, Meng; Xiang, Yu; He, Qiongyi; Gong, Qihuang

2015-01-01

The multipartite entangled state has drawn broad attention for both foundations of quantum mechanics and applications in quantum information processing. Here, we study the spatially separated N -partite continuous-variable Greenberger-Horne-Zeilinger-like states, which can be produced by a linear optical network with squeezed light and N -1 beamsplitters. We investigate the properties of multipartite Einstein-Podolsky-Rosen steering possessed by those states, and find that the steering of a given quantum mode is allowed when not less than half of the modes within the states take part in the steering group. This is certified by the detection of the correlation between position and momentum quadratures of the steered mode and a combination of quadratures of other modes inside the steering group. The steering is evidenced by the high correlation where the steering group can infer the quadratures of the steered mode to high precision, i.e., below the quantum limit for the position and momentum quadratures of the steered quantum mode. We also examine the influence of inefficiency on the multipartite steering, and derive the threshold of the loss tolerance. Furthermore, we discuss the collective N -partite steering induced by the asymmetric loss on beams, which exists when a given quantum mode can only be steered by all the remaining N -1 modes collaboratively. The present multipartite steering correlation may have potential applications in certain quantum information tasks where the issue of trust is important, such as one-sided device-independent quantum secret sharing.

Students' Misconceptions about Random Variables

ERIC Educational Resources Information Center

Kachapova, Farida; Kachapov, Ilias

2012-01-01

This article describes some misconceptions about random variables and related counter-examples, and makes suggestions about teaching initial topics on random variables in general form instead of doing it separately for discrete and continuous cases. The focus is on post-calculus probability courses. (Contains 2 figures.)

Quantization of high dimensional Gaussian vector using permutation modulation with application to information reconciliation in continuous variable QKD

NASA Astrophysics Data System (ADS)

Daneshgaran, Fred; Mondin, Marina; Olia, Khashayar

This paper is focused on the problem of Information Reconciliation (IR) for continuous variable Quantum Key Distribution (QKD). The main problem is quantization and assignment of labels to the samples of the Gaussian variables observed at Alice and Bob. Trouble is that most of the samples, assuming that the Gaussian variable is zero mean which is de-facto the case, tend to have small magnitudes and are easily disturbed by noise. Transmission over longer and longer distances increases the losses corresponding to a lower effective Signal-to-Noise Ratio (SNR) exasperating the problem. Quantization over higher dimensions is advantageous since it allows for fractional bit per sample accuracy which may be needed at very low SNR conditions whereby the achievable secret key rate is significantly less than one bit per sample. In this paper, we propose to use Permutation Modulation (PM) for quantization of Gaussian vectors potentially containing thousands of samples. PM is applied to the magnitudes of the Gaussian samples and we explore the dependence of the sign error probability on the magnitude of the samples. At very low SNR, we may transmit the entire label of the PM code from Bob to Alice in Reverse Reconciliation (RR) over public channel. The side information extracted from this label can then be used by Alice to characterize the sign error probability of her individual samples. Forward Error Correction (FEC) coding can be used by Bob on each subset of samples with similar sign error probability to aid Alice in error correction. This can be done for different subsets of samples with similar sign error probabilities leading to an Unequal Error Protection (UEP) coding paradigm.

Textural features and SUV-based variables assessed by dual time point 18F-FDG PET/CT in locally advanced breast cancer.

PubMed

Garcia-Vicente, Ana María; Molina, David; Pérez-Beteta, Julián; Amo-Salas, Mariano; Martínez-González, Alicia; Bueno, Gloria; Tello-Galán, María Jesús; Soriano-Castrejón, Ángel

2017-12-01

To study the influence of dual time point 18F-FDG PET/CT in textural features and SUV-based variables and their relation among them. Fifty-six patients with locally advanced breast cancer (LABC) were prospectively included. All of them underwent a standard 18F-FDG PET/CT (PET-1) and a delayed acquisition (PET-2). After segmentation, SUV variables (SUVmax, SUVmean, and SUVpeak), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were obtained. Eighteen three-dimensional (3D) textural measures were computed including: run-length matrices (RLM) features, co-occurrence matrices (CM) features, and energies. Differences between all PET-derived variables obtained in PET-1 and PET-2 were studied. Significant differences were found between the SUV-based parameters and MTV obtained in the dual time point PET/CT, with higher values of SUV-based variables and lower MTV in the PET-2 with respect to the PET-1. In relation with the textural parameters obtained in dual time point acquisition, significant differences were found for the short run emphasis, low gray-level run emphasis, short run high gray-level emphasis, run percentage, long run emphasis, gray-level non-uniformity, homogeneity, and dissimilarity. Textural variables showed relations with MTV and TLG. Significant differences of textural features were found in dual time point 18F-FDG PET/CT. Thus, a dynamic behavior of metabolic characteristics should be expected, with higher heterogeneity in delayed PET acquisition compared with the standard PET. A greater heterogeneity was found in bigger tumors.

7 CFR 56.58 - Advance information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 3 2013-01-01 2013-01-01 false Advance information. 56.58 Section 56.58 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... EGGS Grading of Shell Eggs Grading Certificates § 56.58 Advance information. Upon request of an...

Oxygen Compatibility and Challenge Testing of the PLSS Variable Oxygen Regulator (VOR) for the Advanced EMU

NASA Technical Reports Server (NTRS)

Campbell, Colin; Cox, Marlon; Meginnis, Carly; Falconi, Eric

2017-01-01

The Variable Oxygen Regulator (VOR), a stepper actuated two-stage mechanical regulator, is being developed for the purpose of serving as the Primary Oxygen Regulator (POR) and Secondary Oxygen Regulator (SOR) within the Advanced EMU PLSS, now referred to as the xEMU and xPLSS. Three prototype designs have been fabricated and tested as part of this development. Building upon the lessons learned from the 35 years of Shuttle/ISS EMU Program operation including the fleet-wide EMU Secondary Oxygen Pack (SOP) contamination failure that occurred in 2000, the VOR is being analyzed, designed, and tested for oxygen compatibility with controlled Non-Volatile Residue (NVR) and a representative worst-case hydro-carbon system contamination event (>100mg/sq ft dodecane). This paper discusses the steps taken in testing of VOR 2.0 with for oxygen compatibility and then discusses follow-on design changes implemented in the VOR 3.0 (3rd prototype) as a result.

Connecting the Dots: Rediscovering Continuity

ERIC Educational Resources Information Center

Camenga, Kristin A.; Yates, Rebekah B. Johnson

2014-01-01

The topic of continuity is typically not introduced until calculus and then reexamined in real analysis. Recognizing the connections between secondary school mathematics and the advanced mathematics studied at the college level allows teachers to better identify mathematical concepts in student ideas, motivate students by piquing their curiosity,…

Biochemical separations by continuous-bed chromatography.

PubMed

Tisch, T L; Frost, R; Liao, J L; Lam, W K; Remy, A; Scheinpflug, E; Siebert, C; Song, H; Stapleton, A

1998-08-07

Innovations in column-packing media for biomolecule purification have progressed from large spherical, porous polysaccharide beads to advanced polymeric supports. Continuous-bed technology is a radical new technology for chromatography based on the polymerization of advanced monomers and ionomers directly in the chromatographic column. The polymer chains form aggregates which coalesce into a dense, homogeneous network of interconnected nodules consisting of microparticles with an average diameter of 3000 A. The voids or channels between the nodules are large enough to permit a high hydrodynamic flow. Due to the high cross-linking of the polymer matrix, the surface of each nodule is nonporous yet the polymeric microparticles provide a very large surface area for high binding capacity. This paper will demonstrate the properties and advantages of using a continuous bed support for high resolution biomolecule separations at high flow-rates without sacrificing capacity.

Interactions of Task and Subject Variables among Continuous Performance Tests

ERIC Educational Resources Information Center

Denney, Colin B.; Rapport, Mark D.; Chung, Kyong-Mee

2005-01-01

Background: Contemporary models of working memory suggest that target paradigm (TP) and target density (TD) should interact as influences on error rates derived from continuous performance tests (CPTs). The present study evaluated this hypothesis empirically in a typically developing, ethnically diverse sample of children. The extent to which…

SEOM's Sentinel-3/OLCI' project CAWA: advanced GRASP aerosol retrieval

NASA Astrophysics Data System (ADS)

Dubovik, Oleg; litvinov, Pavel; Huang, Xin; Aspetsberger, Michael; Fuertes, David; Brockmann, Carsten; Fischer, Jürgen; Bojkov, Bojan

2016-04-01

The CAWA "Advanced Clouds, Aerosols and WAter vapour products for Sentinel-3/OLCI" ESA-SEOM project aims on the development of advanced atmospheric retrieval algorithms for the Sentinel-3/OLCI mission, and is prepared using Envisat/MERIS and Aqua/MODIS datasets. This presentation discusses mainly CAWA aerosol product developments and results. CAWA aerosol retrieval uses recently developed GRASP algorithm (Generalized Retrieval of Aerosol and Surface Properties) algorithm described by Dubovik et al. (2014). GRASP derives extended set of atmospheric parameters using multi-pixel concept - a simultaneous fitting of a large group of pixels under additional a priori constraints limiting the time variability of surface properties and spatial variability of aerosol properties. Over land GRASP simultaneously retrieves properties of both aerosol and underlying surface even over bright surfaces. GRAPS doesn't use traditional look-up-tables and performs retrieval as search in continuous space of solution. All radiative transfer calculations are performed as part of the retrieval. The results of comprehensive sensitivity tests, as well as results obtained from real Envisat/MERIS data will be presented. The tests analyze various aspects of aerosol and surface reflectance retrieval accuracy. In addition, the possibilities of retrieval improvement by means of implementing synergetic inversion of a combination of OLCI data with observations by SLSTR are explored. Both the results of numerical tests, as well as the results of processing several years of Envisat/MERIS data illustrate demonstrate reliable retrieval of AOD (Aerosol Optical Depth) and surface BRDF. Observed retrieval issues and advancements will be discussed. For example, for some situations we illustrate possibilities of retrieving aerosol absorption - property that hardly accessible from satellite observations with no multi-angular and polarimetric capabilities.

VARIABLE-THROW CAM

DOEpatents

Godsil, E.C.; Robinson, E.Y.

1963-07-16

A variable-throw cam comprising inner and outer eccentric sleeves which are adjustably locked together is described. The cam throw is varied by unlocking the inner and outer sleeves, rotating the outer sleeve relative to the inner one until the desired throw is obtained, and locking the sleeves together again. The cam is useful in applications wherein a continuously-variable throw is required, e.g., ram-and-die pressing operations, cyclic fatigue testing of materials, etc. (AEC)

7 CFR 70.93 - Advance information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 3 2013-01-01 2013-01-01 false Advance information. 70.93 Section 70.93 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Advance information. Upon request of an applicant, all or part of the contents of any grading certificate...

Continuous Glucose Monitoring: A Review of Successes, Challenges, and Opportunities.

PubMed

Rodbard, David

2016-02-01

Continuous glucose monitoring (CGM) provides information unattainable by intermittent capillary blood glucose, including instantaneous real-time display of glucose level and rate of change of glucose, alerts and alarms for actual or impending hypo- and hyperglycemia, "24/7" coverage, and the ability to characterize glycemic variability. Progressively more accurate and precise, reasonably unobtrusive, small, comfortable, user-friendly devices connect to the Internet to share information and are sine qua non for a closed-loop artificial pancreas. CGM can inform, educate, motivate, and alert people with diabetes. CGM is medically indicated for patients with frequent, severe, or nocturnal hypoglycemia, especially in the presence of hypoglycemia unawareness. Surprisingly, despite tremendous advances, utilization of CGM has remained fairly limited to date. Barriers to use have included the following: (1) lack of Food and Drug Administration approval, to date, for insulin dosing ("nonadjuvant use") in the United States and for use in hospital and intensive care unit settings; (2) cost and variable reimbursement; (3) need for recalibrations; (4) periodic replacement of sensors; (5) day-to-day variability in glycemic patterns, which can limit the predictability of findings based on retrospective, masked "professional" use; (6) time, implicit costs, and inconvenience for uploading of data for retrospective analysis; (7) lack of fair and reasonable reimbursement for physician time; (8) inexperience and lack of training of physicians and other healthcare professionals regarding interpretation of CGM results; (9) lack of standardization of software methods for analysis of CGM data; and (10) need for professional medical organizations to develop and disseminate additional clinical practice guidelines regarding the role of CGM. Ongoing advances in technology and clinical research have addressed several of these barriers. Use of CGM in conjunction with an insulin pump with

Continuous Glucose Monitoring: A Review of Successes, Challenges, and Opportunities

PubMed Central

2016-01-01

Abstract Continuous glucose monitoring (CGM) provides information unattainable by intermittent capillary blood glucose, including instantaneous real-time display of glucose level and rate of change of glucose, alerts and alarms for actual or impending hypo- and hyperglycemia, “24/7” coverage, and the ability to characterize glycemic variability. Progressively more accurate and precise, reasonably unobtrusive, small, comfortable, user-friendly devices connect to the Internet to share information and are sine qua non for a closed-loop artificial pancreas. CGM can inform, educate, motivate, and alert people with diabetes. CGM is medically indicated for patients with frequent, severe, or nocturnal hypoglycemia, especially in the presence of hypoglycemia unawareness. Surprisingly, despite tremendous advances, utilization of CGM has remained fairly limited to date. Barriers to use have included the following: (1) lack of Food and Drug Administration approval, to date, for insulin dosing (“nonadjuvant use”) in the United States and for use in hospital and intensive care unit settings; (2) cost and variable reimbursement; (3) need for recalibrations; (4) periodic replacement of sensors; (5) day-to-day variability in glycemic patterns, which can limit the predictability of findings based on retrospective, masked “professional” use; (6) time, implicit costs, and inconvenience for uploading of data for retrospective analysis; (7) lack of fair and reasonable reimbursement for physician time; (8) inexperience and lack of training of physicians and other healthcare professionals regarding interpretation of CGM results; (9) lack of standardization of software methods for analysis of CGM data; and (10) need for professional medical organizations to develop and disseminate additional clinical practice guidelines regarding the role of CGM. Ongoing advances in technology and clinical research have addressed several of these barriers. Use of CGM in conjunction with an

26 CFR 1.801-7 - Variable annuities.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) INCOME TAXES (CONTINUED) Life Insurance Companies § 1.801-7 Variable annuities. (a) In general. (1... variable annuity contract vary with the insurance company's investment experience with respect to such.... Accordingly, a company issuing variable annuity contracts shall qualify as a life insurance company for...

26 CFR 1.801-7 - Variable annuities.

Code of Federal Regulations, 2012 CFR

2012-04-01

...) INCOME TAXES (CONTINUED) Life Insurance Companies § 1.801-7 Variable annuities. (a) In general. (1... variable annuity contract vary with the insurance company's investment experience with respect to such.... Accordingly, a company issuing variable annuity contracts shall qualify as a life insurance company for...

26 CFR 1.801-7 - Variable annuities.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) INCOME TAXES (CONTINUED) Life Insurance Companies § 1.801-7 Variable annuities. (a) In general. (1... variable annuity contract vary with the insurance company's investment experience with respect to such.... Accordingly, a company issuing variable annuity contracts shall qualify as a life insurance company for...

26 CFR 1.801-7 - Variable annuities.

Code of Federal Regulations, 2011 CFR

2011-04-01

...) INCOME TAXES (CONTINUED) Life Insurance Companies § 1.801-7 Variable annuities. (a) In general. (1... variable annuity contract vary with the insurance company's investment experience with respect to such.... Accordingly, a company issuing variable annuity contracts shall qualify as a life insurance company for...

Current status of core and advanced adult gastrointestinal endoscopy training in Canada: Survey of existing accredited programs

PubMed Central

Xiong, Xin; Barkun, Alan N; Waschke, Kevin; Martel, Myriam

2013-01-01

OBJECTIVE: To determine the current status of core and advanced adult gastroenterology training in Canada. METHODS: A survey consisting of 20 questions pertaining to core and advanced endoscopy training was circulated to 14 accredited adult gastroenterology residency program directors. For continuous variables, median and range were analyzed; for categorical variables, percentage and associated 95% CIs were analyzed. RESULTS: All 14 programs responded to the survey. The median number of core trainees was six (range four to 16). The median (range) procedural volumes for gastroscopy, colonoscopy, percutaneous endoscopic gastrostomy and sigmoidoscopy, respectively, were 400 (150 to 1000), 325 (200 to 1500), 15 (zero to 250) and 60 (25 to 300). Eleven of 13 (84.6%) programs used endoscopy simulators in their curriculum. Eight of 14 programs (57%) provided a structured advanced endoscopy training fellowship. The majority (88%) offered training of combined endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasonography. The median number of positions offered yearly for advanced endoscopy fellowship was one (range one to three). The median (range) procedural volumes for ERCP, endoscopic ultrasonography and endoscopic mucosal resection, respectively, were 325 (200 to 750), 250 (80 to 400) and 20 (10 to 63). None of the current programs offered training in endoscopic submucosal dissection or natural orifice transluminal endoscopic surgery. CONCLUSION: Most accredited adult Canadian gastroenterology programs met the minimal procedural requirements recommended by the Canadian Association of Gastroenterology during core training. However, a more heterogeneous experience has been observed for advanced training. Additional studies would be required to validate and standardize evaluation tools used during gastroenterology curricula. PMID:23712301

Current status of core and advanced adult gastrointestinal endoscopy training in Canada: Survey of existing accredited programs.

PubMed

Xiong, Xin; Barkun, Alan N; Waschke, Kevin; Martel, Myriam

2013-01-01

To determine the current status of core and advanced adult gastroenterology training in Canada. A survey consisting of 20 questions pertaining to core and advanced endoscopy training was circulated to 14 accredited adult gastroenterology residency program directors. For continuous variables, median and range were analyzed; for categorical variables, percentage and associated 95% CIs were analyzed. All 14 programs responded to the survey. The median number of core trainees was six (range four to 16). The median (range) procedural volumes for gastroscopy, colonoscopy, percutaneous endoscopic gastrostomy and sigmoidoscopy, respectively, were 400 (150 to 1000), 325 (200 to 1500), 15 (zero to 250) and 60 (25 to 300). Eleven of 13 (84.6%) programs used endoscopy simulators in their curriculum. Eight of 14 programs (57%) provided a structured advanced endoscopy training fellowship. The majority (88%) offered training of combined endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasonography. The median number of positions offered yearly for advanced endoscopy fellowship was one (range one to three). The median (range) procedural volumes for ERCP, endoscopic ultrasonography and endoscopic mucosal resection, respectively, were 325 (200 to 750), 250 (80 to 400) and 20 (10 to 63). None of the current programs offered training in endoscopic submucosal dissection or natural orifice transluminal endoscopic surgery. Most accredited adult Canadian gastroenterology programs met the minimal procedural requirements recommended by the Canadian Association of Gastroenterology during core training. However, a more heterogeneous experience has been observed for advanced training. Additional studies would be required to validate and standardize evaluation tools used during gastroenterology curricula.

Continuous palliative sedation for patients with advanced cancer at a tertiary care cancer center.

PubMed

Prado, Bernard Lobato; Gomes, Diogo Bugano Diniz; Usón Júnior, Pedro Luiz Serrano; Taranto, Patricia; França, Monique Sedlmaier; Eiger, Daniel; Mariano, Rodrigo Coutinho; Hui, David; Del Giglio, Auro

2018-01-04

Palliative sedation (PS) is an intervention to treat refractory symptoms and to relieve suffering at the end of life. Its prevalence and practice patterns vary widely worldwide. The aim of our study was to evaluate the frequency, clinical indications and outcomes of PS in advanced cancer patients admitted to our tertiary comprehensive cancer center. We retrospectively studied the use of PS in advanced cancer patients who died between March 1st, 2012 and December 31st, 2014. PS was defined as the use of continuous infusion of midazolam or neuroleptics for refractory symptoms in the end of life. This study was approved by the Research Ethics Committee of our institution (project number 2481-15). During the study period, 552 cancer patients died at the institution and 374 met the inclusion criteria for this study. Main reason for exclusion was death in the Intensive Care Unit. Among all included patients, 54.2% (n = 203) received PS. Patients who received PS as compared to those not sedated were younger (67.8 vs. 76.4 years-old, p < 0.001) and more likely to have a diagnosis of lung cancer (23% vs. 14%, p = 0.028). The most common indications for sedation were dyspnea (55%) and delirium (19.7%) and the most common drugs used were midazolam (52.7%) or midazolam and a neuroleptic (39.4%). Median initial midazolam infusion rate was 0.75 mg/h (interquartile range - IQR - 0.6-1.5) and final rate was 1.5 mg/h (IQR 0.9-3.0). Patient survival (length of hospital stay from admission to death) of those who had PS was more than the double of those who did not (33.6 days vs 16 days, p < 0.001). The palliative care team was involved in the care of 12% (n = 25) of sedated patients. PS is a relatively common practice in the end-of-life of cancer patients at our hospital and it is not associated with shortening of hospital stay. Involvement of a dedicated palliative care team is strongly recommended if this procedure is being considered. Further research is

7 CFR 58.21 - Advance information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 3 2013-01-01 2013-01-01 false Advance information. 58.21 Section 58.21 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Grading Service § 58.21 Advance information. Upon request of an applicant, all or part of the contents of...

Advanced Intensity-Modulation Continuous-Wave Lidar Techniques for Column CO2 Measurements

NASA Astrophysics Data System (ADS)

Campbell, J. F.; Lin, B.; Nehrir, A. R.; Obland, M. D.; Liu, Z.; Browell, E. V.; Chen, S.; Kooi, S. A.; Fan, T. F.

2015-12-01

Global and regional atmospheric carbon dioxide (CO2) measurements for the NASA Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) space mission and Atmospheric Carbon and Transport (ACT) - America airborne investigation are critical for improving our understanding of global CO2 sources and sinks. Advanced Intensity-Modulated Continuous-Wave (IM-CW) lidar techniques are being investigated as a means of facilitating CO2 measurements from space and airborne platforms to meet the mission science measurement requirements. In recent numerical, laboratory and flight experiments we have successfully used the Binary Phase Shift Keying (BPSK) modulation technique to uniquely discriminate surface lidar returns from intermediate aerosol and cloud returns. We demonstrate the utility of BPSK to eliminate sidelobes in the range profile as a means of making Integrated Path Differential Absorption (IPDA) column CO2 measurements in the presence of intervening optically thin clouds, thereby minimizing bias errors caused by the clouds. Furthermore, high accuracy and precision ranging to the Earth's surface as well as to the top of intermediate cloud layers, which is a requirement for the inversion of column CO2 number density measurements to column CO2 mixing ratios, has been demonstrated using new hyperfine interpolation techniques that takes advantage of the periodicity of the modulation waveforms. This approach works well for both BPSK and linear swept-frequency modulation techniques and provides very high (at sub-meter level) range resolution. The BPSK technique under investigation has excellent auto-correlation properties while possessing a finite bandwidth. A comparison of BPSK and linear swept-frequency is also discussed in this paper. These techniques are used in a new data processing architecture to support the ASCENDS CarbonHawk Experiment Simulator (ACES) and ACT-America programs.

10 CFR 75.44 - Timing of advance notification.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Timing of advance notification. 75.44 Section 75.44 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT Advanced Notification and Expenses § 75.44 Timing of advance notification. (a) Except as provided...

10 CFR 75.44 - Timing of advance notification.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Timing of advance notification. 75.44 Section 75.44 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT Advanced Notification and Expenses § 75.44 Timing of advance notification. (a) Except as provided...

19 CFR 181.94 - Nonconforming requests for advance rulings.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Nonconforming requests for advance rulings. 181.94...; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Advance Ruling Procedures § 181.94 Nonconforming requests for advance rulings. A person submitting a request for an advance ruling that does not...

A Bayesian Semiparametric Latent Variable Model for Mixed Responses

ERIC Educational Resources Information Center

Fahrmeir, Ludwig; Raach, Alexander

2007-01-01

In this paper we introduce a latent variable model (LVM) for mixed ordinal and continuous responses, where covariate effects on the continuous latent variables are modelled through a flexible semiparametric Gaussian regression model. We extend existing LVMs with the usual linear covariate effects by including nonparametric components for nonlinear…

Clinical benefit of continuing crizotinib therapy after initial disease progression in Chinese patients with advanced ALK-rearranged non-small-cell lung cancer

PubMed Central

Hong, Xiangchan; Chen, Qi; Ding, Lingyu; Liang, Ying; Zhou, Ningning; Fang, Wenfeng; Chen, Xinru; Wu, Haiying

2017-01-01

Purpose Although most patients with ALK-positive non?small-cell lung cancer (NSCLC) who benefit from treatment with crizotinib ultimately develop progressive disease (PD), continuing crizotinb beyond the initial PD (CBPD) in these patients may be beneficial. In this study, we investigated whether Chinese patients with advanced ALK-positive NSCLC benefit from CBPD, and whether any factors are predictive of a longer post-initial progression-free survival time (PFS2). Materials and Methods Data on 33 patients with ALK-positive NSCLC who achieved disease control with crizotinib were analyzed retrospectively. The impact of continued crizotinib therapy on the patients’ PFS2 time was assessed after adjusting for potential confounding factors. Results With initial crizotinib therapy, the objective response rate (ORR) and median PFS time (PFS1) in the 33 patients were 63.6% and 8.6 months, respectively. With continued crizotinib therapy after documentation of PD, the median PFS2 for all 33 patients was 16 weeks, and in those with CNS progression but systemic disease control it was 30 weeks. Patients who received local therapy after disease progression had a significantly longer PFS2 compared with those who did not (P = 0.039). Multivariable Cox regression analysis showed that the PFS1 with initial crizotinib treatment and local therapy were independent predictors of PFS2. Discussion This study provides further evidence of the benefit of continuing crizotinib therapy in Chinese patients with progressive ALK-positive NSCLC. Patients with a longer PFS1 and those who received local brain therapy would have a longer period of continuing crizotinib. PMID:28427213

Clinical benefit of continuing crizotinib therapy after initial disease progression in Chinese patients with advanced ALK-rearranged non-small-cell lung cancer.

PubMed

Hong, Xiangchan; Chen, Qi; Ding, Lingyu; Liang, Ying; Zhou, Ningning; Fang, Wenfeng; Chen, Xinru; Wu, Haiying

2017-06-20

Although most patients with ALK-positive non-small-cell lung cancer (NSCLC) who benefit from treatment with crizotinib ultimately develop progressive disease (PD), continuing crizotinb beyond the initial PD (CBPD) in these patients may be beneficial. In this study, we investigated whether Chinese patients with advanced ALK-positive NSCLC benefit from CBPD, and whether any factors are predictive of a longer post-initial progression-free survival time (PFS2). Data on 33 patients with ALK-positive NSCLC who achieved disease control with crizotinib were analyzed retrospectively. The impact of continued crizotinib therapy on the patients' PFS2 time was assessed after adjusting for potential confounding factors. With initial crizotinib therapy, the objective response rate (ORR) and median PFS time (PFS1) in the 33 patients were 63.6% and 8.6 months, respectively. With continued crizotinib therapy after documentation of PD, the median PFS2 for all 33 patients was 16 weeks, and in those with CNS progression but systemic disease control it was 30 weeks. Patients who received local therapy after disease progression had a significantly longer PFS2 compared with those who did not (P = 0.039). Multivariable Cox regression analysis showed that the PFS1 with initial crizotinib treatment and local therapy were independent predictors of PFS2. This study provides further evidence of the benefit of continuing crizotinib therapy in Chinese patients with progressive ALK-positive NSCLC. Patients with a longer PFS1 and those who received local brain therapy would have a longer period of continuing crizotinib.

A 3-D Computational Study of a Variable Camber Continuous Trailing Edge Flap (VCCTEF) Spanwise Segment

NASA Technical Reports Server (NTRS)

Kaul, Upender K.; Nguyen, Nhan T.

2015-01-01

Results of a computational study carried out to explore the effects of various elastomer configurations joining spanwise contiguous Variable Camber Continuous Trailing Edge Flap (VCCTEF) segments are reported here. This research is carried out as a proof-of-concept study that will seek to push the flight envelope in cruise with drag optimization as the objective. The cruise conditions can be well off design such as caused by environmental conditions, maneuvering, etc. To handle these off-design conditions, flap deflection is used so when the flap is deflected in a given direction, the aircraft angle of attack changes accordingly to maintain a given lift. The angle of attack is also a design parameter along with the flap deflection. In a previous 2D study,1 the effect of camber was investigated and the results revealed some insight into the relative merit of various camber settings of the VCCTEF. The present state of the art has not advanced sufficiently to do a full 3-D viscous analysis of the whole NASA Generic Transport Model (GTM) wing with VCCTEF deployed with elastomers. Therefore, this study seeks to explore the local effects of three contiguous flap segments on lift and drag of a model devised here to determine possible trades among various flap deflections to achieve desired lift and drag results. Although this approach is an approximation, it provides new insights into the "local" effects of the relative deflections of the contiguous spanwise flap systems and various elastomer segment configurations. The present study is a natural extension of the 2-D study to assess these local 3-D effects. Design cruise condition at 36,000 feet at free stream Mach number of 0.797 and a mean aerodynamic chord (MAC) based Reynolds number of 30.734x10(exp 6) is simulated for an angle of attack (AoA) range of 0 to 6 deg. In the previous 2-D study, the calculations revealed that the parabolic arc camber (1x2x3) and circular arc camber (VCCTEF222) offered the best L

7 CFR 1980.472 - Protective advances.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE (CONTINUED... liquidation is contemplated or in process. A precise rule of when a protective advance should be made is...

CTPPL: A Continuous Time Probabilistic Programming Language

DTIC Science & Technology

2009-07-01

recent years there has been a flurry of interest in continuous time models, mostly focused on continuous time Bayesian networks ( CTBNs ) [Nodelman, 2007... CTBNs are built on homogenous Markov processes. A homogenous Markov pro- cess is a finite state, continuous time process, consisting of an initial...q1 : xn()] ... Some state transitions can produce emissions. In a CTBN , each variable has a conditional inten- sity matrix Qu for every combination of

Water-quality variability and constituent transport and processes in streams of Johnson County, Kansas, using continuous monitoring and regression models, 2003-11

USGS Publications Warehouse

Rasmussen, Teresa; Gatotho, Jackline

2014-01-01

The population of Johnson County, Kansas increased by about 24 percent between 2000 and 2012, making it one of the most rapidly developing areas of Kansas. The U.S. Geological Survey, in cooperation with the Johnson County Stormwater Management Program, began a comprehensive study of Johnson County streams in 2002 to evaluate and monitor changes in stream quality. The purpose of this report is to describe water-quality variability and constituent transport for streams representing the five largest watersheds in Johnson County, Kansas during 2003 through 2011. The watersheds ranged in urban development from 98.3 percent urban (Indian Creek) to 16.7 percent urban (Kill Creek). Water-quality conditions are quantified among the watersheds of similar size (50.1 square miles to 65.7 square miles) using continuous, in-stream measurements, and using regression models developed from continuous and discrete data. These data are used to quantify variability in concentrations and loads during changing streamflow and seasonal conditions, describe differences among sites, and assess water quality relative to water-quality standards and stream management goals. Water quality varied relative to streamflow conditions, urbanization in the upstream watershed, and contributions from wastewater treatment facilities and storm runoff. Generally, as percent impervious surface (a measure of urbanization) increased, streamflow yield increased. Water temperature of Indian Creek, the most urban site which is also downstream from wastewater facility discharges, was higher than the other sites about 50 percent of the time, particularly during winter months. Dissolved oxygen concentrations were less than the Kansas Department of Health and Environment minimum criterion of 5 milligrams per liter about 15 percent of the time at the Indian Creek site. Dissolved oxygen concentrations were less than the criterion about 10 percent of the time at the rural Blue River and Kill Creek sites, and less than

Regression Analysis with Dummy Variables: Use and Interpretation.

ERIC Educational Resources Information Center

Hinkle, Dennis E.; Oliver, J. Dale

1986-01-01

Multiple regression analysis (MRA) may be used when both continuous and categorical variables are included as independent research variables. The use of MRA with categorical variables involves dummy coding, that is, assigning zeros and ones to levels of categorical variables. Caution is urged in results interpretation. (Author/CH)

Genotypic variability for root/shoot parameters under water stress in some advanced lines of cotton (Gossypium hirsutum L.).

PubMed

Riaz, M; Farooq, J; Sakhawat, G; Mahmood, A; Sadiq, M A; Yaseen, M

2013-02-27

Research pertaining to genetic variability parameters, heritability, and genotypic, phenotypic, simple, and environmental correlations for various seedling traits in five elite advanced cotton (Gossypium hirsutum L.) lines (FH-113, FH-114, FH-941, FH-942, and FH-2015) and one check (CIM-496) was carried out during October and November 2010 under greenhouse conditions at the Cotton Research Institute (Faisalabad, Pakistan). Material was raised in plastic tubes with a randomized complete block design replicated three times. Three drought shocks were applied by withholding water from the tube-sown plants for 8-, 10-, and 12-day intervals. After 60 days of sowing, data on root/shoot traits like root length (cm), shoot length (cm), root weight (g), shoot fresh weight (g), lateral root number, root dry weight (g) shoot dry weight (g), and total plant weight (g) were recorded. Considerable genotypic variations existed between genotypes for all seedling characters. Higher broad-sense heritability estimates were found for all traits studied. Maximum broad-sense heritability coupled with high genetic advance in root length (0.99, 17.34), lateral root number (0.91, 2.89), and shoot length (0.90, 4.35) suggested a potential for genetic improvement through breeding and selection. The correlation coefficients among root length, shoot length, root dry weight, fresh shoot weight, and total plant weight were positively and significantly correlated; thus, they can be selected simultaneously as drought tolerance selection indexes owing to the absence of undesired relationships. Genotypes FH-942 and FH-113 had the lowest excised leaf water loss during the first 4 h and also for the next 4 h. Therefore, these two advanced lines (FH-942 and FH-113) with high initial water content and lower excised leaf water loss had better adaptation to water stress.

Random Variables: Simulations and Surprising Connections.

ERIC Educational Resources Information Center

Quinn, Robert J.; Tomlinson, Stephen

1999-01-01

Features activities for advanced second-year algebra students in grades 11 and 12. Introduces three random variables and considers an empirical and theoretical probability for each. Uses coins, regular dice, decahedral dice, and calculators. (ASK)

Variability, constraints, and creativity. Shedding light on Claude Monet.

PubMed

Stokes, P D

2001-04-01

Recent experimental research suggests 2 things. The first is that along with learning how to do something, people also learn how variably or differently to continue doing it. The second is that high variability is maintained by constraining, precluding a currently successful, often repetitive solution to a problem. In this view, Claude Monet's habitually high level of variability in painting was acquired during his childhood and early apprenticeship and was maintained throughout his adult career by a continuous series of task constraints imposed by the artist on his own work. For Monet, variability was rewarded and rewarding.

Advances in induction-heated plasma torch technology

NASA Technical Reports Server (NTRS)

Poole, J. W.; Vogel, C. E.

1972-01-01

Continuing research has resulted in significant advances in induction-heated plasma torch technology which extend and enhance its potential for broad range of uses in chemical processing, materials development and testing, and development of large illumination sources. Summaries of these advances are briefly described.

High glycemic variability assessed by continuous glucose monitoring after surgical treatment of obesity by gastric bypass.

PubMed

Hanaire, Helene; Bertrand, Monelle; Guerci, Bruno; Anduze, Yves; Guillaume, Eric; Ritz, Patrick

2011-06-01

Obesity surgery elicits complex changes in glucose metabolism that are difficult to observe with discontinuous glucose measurements. We aimed to evaluate glucose variability after gastric bypass by continuous glucose monitoring (CGM) in a real-life setting. CGM was performed for 4.2 ± 1.3 days in three groups of 10 subjects each: patients who had undergone gastric bypass and who were referred for postprandial symptoms compatible with mild hypoglycemia, nonoperated diabetes controls, and healthy controls. The maximum interstitial glucose (IG), SD of IG values, and mean amplitude of glucose excursions (MAGE) were significantly higher in operated patients and in diabetes controls than in healthy controls. The time to the postprandial peak IG was significantly shorter in operated patients (42.8 ± 6.0 min) than in diabetes controls (82.2 ± 11.1 min, P = 0.0002), as were the rates of glucose increase to the peak (2.4 ± 1.6 vs. 1.2 ± 0.3 mg/mL/min; P = 0.041). True hypoglycemia (glucose <60 mg/dL) was rare: the symptoms were probably more related to the speed of IG decrease than to the glucose level achieved. Half of the operated patients, mostly those with a diabetes background before surgery, had postprandial glucose concentrations above 200 mg/dL (maximum IG, 306 ± 59 mg/dL), in contrast to the normal glucose concentrations in the fasting state and 2 h postmeal. Glucose variability is exaggerated after gastric bypass, combining unusually high and early hyperglycemic peaks and rapid IG decreases. This might account for postprandial symptoms mimicking hypoglycemia but often seen without true hypoglycemia. Early postprandial hyperglycemia might be underestimated if glucose measurements are done 2 h postmeal.

Continuous engineering of nano-cocrystals for medical and energetic applications.

PubMed

Spitzer, D; Risse, B; Schnell, F; Pichot, V; Klaumünzer, M; Schaefer, M R

2014-10-10

Cocrystals, solid mixtures of different molecules on molecular scale, are supposed to be tailor made materials with improved employability compared to their pristine individual components in domains such as medicine and explosives. In medicine, cocrystals are obtained by crystallization of active pharmaceutical ingredients with precisely chosen coformers to design medicaments that demonstrate enhanced stability, high solubility, and therefore high bioavailability and optimized drug up-take. Nanoscaling may further advance these characteristica compared to their micronsized counterparts - because of a larger surface to volume ratio of nanoparticles. In the field of energetic materials, cocrystals offer the opportunity to design smart explosives, combining high reactivity with significantly reduced sensitivity, nowadays essential for a safe manipulation and handling. Furthermore, cocrystals are used in ferroelectrics, non-linear material response and electronic organics. However, state of the art batch processes produce low volume of cocrystals of variable quality and only have produced micronsized cocrystals so far, no nano-cocrystals. Here we demonstrate the continuous preparation of pharmaceutical and energetic micro- and nano-cocrystals using the Spray Flash Evaporation process. Our laboratory scale pilot plant continuously prepared up to 8 grams per hour of Caffeine/Oxalic acid 2:1, Caffeine/Glutaric acid 1:1, TNT/CL-20 1:1 and HMX/Cl-20 1:2 nano- and submicronsized cocrystals.

Continuous engineering of nano-cocrystals for medical and energetic applications

NASA Astrophysics Data System (ADS)

Spitzer, D.; Risse, B.; Schnell, F.; Pichot, V.; Klaumünzer, M.; Schaefer, M. R.

2014-10-01

Cocrystals, solid mixtures of different molecules on molecular scale, are supposed to be tailor made materials with improved employability compared to their pristine individual components in domains such as medicine and explosives. In medicine, cocrystals are obtained by crystallization of active pharmaceutical ingredients with precisely chosen coformers to design medicaments that demonstrate enhanced stability, high solubility, and therefore high bioavailability and optimized drug up-take. Nanoscaling may further advance these characteristica compared to their micronsized counterparts - because of a larger surface to volume ratio of nanoparticles. In the field of energetic materials, cocrystals offer the opportunity to design smart explosives, combining high reactivity with significantly reduced sensitivity, nowadays essential for a safe manipulation and handling. Furthermore, cocrystals are used in ferroelectrics, non-linear material response and electronic organics. However, state of the art batch processes produce low volume of cocrystals of variable quality and only have produced micronsized cocrystals so far, no nano-cocrystals. Here we demonstrate the continuous preparation of pharmaceutical and energetic micro- and nano-cocrystals using the Spray Flash Evaporation process. Our laboratory scale pilot plant continuously prepared up to 8 grams per hour of Caffeine/Oxalic acid 2:1, Caffeine/Glutaric acid 1:1, TNT/CL-20 1:1 and HMX/Cl-20 1:2 nano- and submicronsized cocrystals.

Organization and Management of Continuing Education in German and Finnish Universities

ERIC Educational Resources Information Center

Zawacki-Richter, Olaf; Knust, Michaela; Hanft, Anke

2009-01-01

In 2006, an international comparison study investigated the organization and management of university continuing education (UCE). The Finnish continuing education system proved to be especially advanced in this study. On the other hand, it became clear that Germany was still lagging behind in continuing education. In this article, German and…

Clinical outcome of continuous facial nerve monitoring during primary parotidectomy.

PubMed

Terrell, J E; Kileny, P R; Yian, C; Esclamado, R M; Bradford, C R; Pillsbury, M S; Wolf, G T

1997-10-01

To assess whether continuous facial nerve monitoring during parotidectomy is associated with a lower incidence of facial nerve paresis or paralysis compared with parotidectomy without monitoring and to assess the cost of such monitoring. A retrospective analysis of outcomes for patients who underwent parotidectomy with or without continuous facial nerve monitoring. University medical center. Fifty-six patients undergoing parotidectomy in whom continuous electromyographic monitoring was used and 61 patients in whom it was not used. (1) The incidence of early and persistent facial nerve paresis or paralysis and (2) the cost associated with facial nerve monitoring. Early, unintentional facial weakness was significantly lower in the group monitored by electromyograpy (43.6%) than in the unmonitored group (62.3%) (P=.04). In the subgroup of patients without comorbid conditions or surgeries, early weakness in the monitored group (33.3%) remained statistically lower than the rate of early weakness in the unmonitored group (57.5%) (P=.03). There was no statistical difference in the final facial nerve function or incidence of permanent nerve injury between the groups or subgroups. After multivariate analysis, nonmonitored status (odds ratio [OR], 3.22), advancing age (OR, 1.47 per 10 years), and longer operative times (OR, 1.3 per hour) were the only significant independent predictive variables significantly associated with early postoperative facial weakness. The incremental cost of facial nerve monitoring was $379. The results suggest that continuous electromyographic monitoring of facial muscle during primary parotidectomy reduces the incidence of short-term postoperative facial paresis. Advantages and disadvantages of this technique need to be considered together with the additional costs in deciding whether routine use of continuous monitoring is a useful, cost-effective adjunct to parotid surgery.

A Variable Stability Test Vehicle for ITS Applications

NASA Technical Reports Server (NTRS)

Griffin, Daniel C.; Lee, Allan Y.

1996-01-01

A variable stability test bed is under development for the National Highway Traffic Safety Administration (NHTSA). The Variable Dynamic Testbed Vehicle (VDTV) is being designed for research and testing of advanced collision warning and avoidance technologies being developed by industry and most likely being made available to consumers in the near future.

Advancing Variable Star Astronomy: The Centennial History of the American Association of Variable Star Observers

NASA Astrophysics Data System (ADS)

Williams, Thomas R.; Saladyga, Michael

2011-05-01

Preface; Part I. Pioneers in Variable Star Astronomy Prior to 1909: 1. The emergence of variable star astronomy - a need for observations; 2. A need for observers; Part II. The Founding of the AAVSO - The William Tyler Olcott Era: 3. The amateur's amateur; 4. Amateurs in the service of science; Part III. The Leon Campbell Era: 5. Leon Campbell to the rescue; 6. Formalizing relationships; 7. The Pickering Memorial Endowment; 8. Fading of the Old Guard; 9. Growing pains and distractions; Part IV. The Service Bureau - The Margaret Mayall Era: 10. Learning about independence; 11. Eviction from Harvard College Observatory; 12. Actions and reactions; 13. In search of a home; 14. Survival on Brattle Street; 15. AAVSO achievements; 16. Breathing room on Concord Avenue; Part V. Analysis and Science: The Janet Mattei Era: 17. The growth of a director; 18. Learning the ropes the hard way; 19. Managing with renewed confidence; 20. Expanding the scientific charter; Part VI. Accelerating Observational Science - The Arne Henden Era: 21. Bridging the gap; 22. Accelerating the science - the Henden era begins; Epilogue; Appendices; Index.

Advanced access appointments

PubMed Central

Hudec, John C.; MacDougall, Steven; Rankin, Elaine

2010-01-01

ABSTRACT OBJECTIVE To examine the effects of advanced access (same-day physician appointments) on patient and provider satisfaction and to determine its association with other variables such as physician income and patient emergency department use. DESIGN Patient satisfaction survey and semistructured interviews with physicians and support staff; analysis of physician medical insurance billings and patient emergency department visits. SETTING Cape Breton, NS. PARTICIPANTS Patients, physicians, and support staff of 3 comparable family physician practices that had not implemented advanced access and an established advanced access practice. MAIN OUTCOME MEASURES Self-reported provider and patient satisfaction, physician office income, and patients’ emergency department use. RESULTS The key benefits of implementation of advanced access were an increase in provider and patient satisfaction levels, same or greater physician office income, and fewer less urgent (triage level 4) and nonurgent (triage level 5) emergency department visits by patients. CONCLUSION Currently within the Central Cape Breton Region, 33% of patients wait 4 or more days for urgent appointments. Findings from this study can be used to enhance primary care physician practice redesign. This research supports many benefits of transitioning to an advanced access model of patient booking. PMID:20944024

Physical Therapy Continuing Education. Part II: Motivating Factors.

ERIC Educational Resources Information Center

Karp, Nancy V.

1992-01-01

A survey of Georgia physical therapists received responses from 74.7 percent. Results identified the following motivations for continuing education: knowledge, meeting licensure requirements, and advancing in the present job. (SK)

The Continuity Project, Fall 1997 Report.

ERIC Educational Resources Information Center

Wasilko, Peter J.

The Continuity Project is a research, development, and technology transfer initiative aimed at creating a "Library of the Future" by combining features of an online public access catalog (OPAC) and a campus wide information system (CWIS) with advanced facilities drawn from such areas as artificial intelligence (AI), knowledge…

Continuous intraperitoneal insulin infusion versus subcutaneous insulin therapy in the treatment of type 1 diabetes: effects on glycemic variability.

PubMed

van Dijk, Peter R; Groenier, Klaas H; DeVries, J Hans; Gans, Reinold O B; Kleefstra, Nanno; Bilo, Henk J G; Logtenberg, Susan J J

2015-06-01

As continuous intraperitoneal insulin infusion (CIPII) results in a more physiologic action of insulin than subcutaneous (SC) insulin administration, we hypothesized that CIPII would result in less glycemic variability (GV) than SC insulin therapy among type 1 diabetes mellitus (T1DM) patients. Data from 5-day blind continuous glucose monitoring (CGM) measurements performed during a 26-week, prospective, observational case-control study were analyzed. The coefficient of variation (CV) was the primary measure of GV. In addition, the SD of the mean glucose level, mean of daily differences, and mean amplitude of glycemic excursions were calculated. In total, 176 patients (36% male; mean age, 49 [SD 13] years; median diabetes duration, 24 [interquartile range, 17, 35] years; glycated hemoglobin level, 63 [10] mmol/mmol), of which 37 used CIPII and 139 SC insulin therapy, were analyzed. CGM data were available for 169 patients at baseline (CIPII, n=35; SC, n=134) and for 164 patients at 26 weeks (CIPII, n=35; SC, n=129). After adjustment for baseline differences, the CV was 4.9% (95% confidence interval, 1.0, 8.8) lower with CIPII- compared with SC-treated patients, irrespective of the use of multiple daily injections or continuous SC insulin infusion. There were no differences in other indices of GV between groups. Despite higher blood glucose, the CV was slightly lower with CIPII compared with SC insulin therapy in T1DM patients, and other measures of GV were identical. Future studies are needed to confirm these findings and investigate whether this results in prevention of hypoglycemia and even perhaps (less) microvascular complications.

Conducting Biobehavioral Research in Patients With Advanced Cancer: Recruitment Challenges and Solutions.

PubMed

Gilbertson-White, Stephanie; Bohr, Nicole; Wickersham, Karen E

2017-10-01

Despite significant advances in cancer treatment and symptom management interventions over the last decade, patients continue to struggle with cancer-related symptoms. Adequate baseline and longitudinal data are crucial for designing interventions to improve patient quality of life and reduce symptom burden; however, recruitment of patients with advanced cancer in longitudinal research is difficult. Our purpose is to describe challenges and solutions to recruitment of patients with advanced cancer in two biobehavioral research studies examining cancer-related symptoms. Study 1: Symptom data and peripheral blood for markers of inflammation were collected from newly diagnosed patients receiving chemotherapy on the first day of therapy and every 3-4 weeks for up to 6 months. Study 2: Symptom data, blood, and skin biopsies were collected from cancer patients taking epidermal growth factor receptor inhibitors at specific time points over 4 months. Screening and recruitment results for both studies are summarized. Timing informed consent with baseline data collection prior to treatment initiation was a significant recruitment challenge for both the studies. Possible solutions include tailoring recruitment to fit clinic needs, increasing research staff availability during clinic hours, and adding recruitment sites. Identifying solutions to these challenges will permit the conduct of studies that may lead to identification of factors contributing to variability in symptoms and development of tailored patient interventions for patients with advanced cancer.

Assimilation of remote sensing observations into a continuous distributed hydrological model: impacts on the hydrologic cycle

NASA Astrophysics Data System (ADS)

Laiolo, Paola; Gabellani, Simone; Campo, Lorenzo; Cenci, Luca; Silvestro, Francesco; Delogu, Fabio; Boni, Giorgio; Rudari, Roberto

2015-04-01

The reliable estimation of hydrological variables (e.g. soil moisture, evapotranspiration, surface temperature) in space and time is of fundamental importance in operational hydrology to improve the forecast of the rainfall-runoff response of catchments and, consequently, flood predictions. Nowadays remote sensing can offer a chance to provide good space-time estimates of several hydrological variables and then improve hydrological model performances especially in environments with scarce in-situ data. This work investigates the impact of the assimilation of different remote sensing products on the hydrological cycle by using a continuous physically based distributed hydrological model. Three soil moisture products derived by ASCAT (Advanced SCATterometer) are used to update the model state variables. The satellite-derived products are assimilated into the hydrological model using different assimilation techniques: a simple nudging and the Ensemble Kalman Filter. Moreover two assimilation strategies are evaluated to assess the impact of assimilating the satellite products at model spatial resolution or at the satellite scale. The experiments are carried out for three Italian catchments on multi year period. The benefits on the model predictions of discharge, LST, evapotranspiration and soil moisture dynamics are tested and discussed.

[Advance directives and advance care planning].

PubMed

Vayne-Bossert, Petra; Vailloud, Christiane; Ducloux, Dominique; Matis, Caroline; Déramé, Laurence

2017-02-01

Advance directives (AD) and Advance Care Planning (ACP) are two measures a person may undertake to assure that their treatment preferences will be respected until the end of his / her life. Anticipation is based on an open and honest communication between the patient, the durable medical power of attorney and the health care professionals. ADs and ACPs are based on a person's values and beliefs that are important to his quality of life. ACP is a continuing process, initiated by health care professionals and integrated into the health care plan of a person. It should be adjusted all along the disease trajectory and favors communication and anticipation in the health care network. ADs are often a personal initiative to ensure one's wishes in relation to health issues. In Switzerland, they are based on a legal framework and their application is therefore mandatory for health care professionals.

Variable orifice using an iris shutter

DOEpatents

Beeman, Raymond; Brajkovich, Steven J.

1978-01-01

A variable orifice forming mechanism utilizing an iris shutter arrangement adapted to control gas flow, conductance in vacuum systems, as a heat shield for furnace windows, as a beam shutter in sputtering operations, and in any other application requiring periodic or continuously-variable control of material, gas, or fluid flow.

19 CFR 181.97 - Withdrawal of NAFTA advance ruling requests.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Withdrawal of NAFTA advance ruling requests. 181...; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Advance Ruling Procedures § 181.97 Withdrawal of NAFTA advance ruling requests. Any request for an advance ruling may be withdrawn by the person...

Advancing Public Health through Continuing Education of Health Care Professionals

ERIC Educational Resources Information Center

Hudmon, Karen Suchanek; Addleton, Robert L.; Vitale, Frank M.; Christiansen, Bruce A.; Mejicano, George C.

2011-01-01

This article describes how the CS2day (Cease Smoking Today) initiative positioned continuing education (CE) in the intersection between medicine and public health. The authors suggest that most CE activities address the medical challenges that clinicians confront, often to the neglect of the public health issues that are key risk factors for the…

Simulated dynamic response of a multi-stage compressor with variable molecular weight flow medium

NASA Technical Reports Server (NTRS)

Babcock, Dale A.

1995-01-01

A mathematical model of a multi-stage compressor with variable molecular weight flow medium is derived. The modeled system consists of a five stage, six cylinder, double acting, piston type compressor. Each stage is followed by a water cooled heat exchanger which serves to transfer the heat of compression from the gas. A high molecular weight gas (CFC-12) mixed with air in varying proportions is introduced to the suction of the compressor. Condensation of the heavy gas may occur in the upper stage heat exchangers. The state equations for the system are integrated using the Advanced Continuous Simulation Language (ACSL) for determining the system's dynamic and steady state characteristics under varying operating conditions.

Education of advanced practice nurses in Canada.

PubMed

Martin-Misener, Ruth; Bryant-Lukosius, Denise; Harbman, Patricia; Donald, Faith; Kaasalainen, Sharon; Carter, Nancy; Kilpatrick, Kelley; DiCenso, Alba

2010-12-01

In Canada, education programs for the clinical nurse specialist (CNS) and nurse practitioner (NP) roles began 40 years ago. NP programs are offered in almost all provinces. Education for the CNS role has occurred through graduate nursing programs generically defined as providing preparation for advanced nursing practice. For this paper, we drew on pertinent sections of a scoping review of the literature and key informant interviews conducted for a decision support synthesis on advanced practice nursing to describe the following: (1) history of advanced practice nursing education in Canada, (2) current status of advanced practice nursing education in Canada, (3) curriculum issues, (4) interprofessional education, (5) resources for education and (6) continuing education. Although national frameworks defining advanced nursing practice and NP competencies provide some direction for education programs, Canada does not have countrywide standards of education for either the NP or CNS role. Inconsistency in the educational requirements for primary healthcare NPs continues to cause significant problems and interferes with inter-jurisdictional licensing portability. For both CNSs and NPs, there can be a mismatch between a generalized education and specialized practice. The value of interprofessional education in facilitating effective teamwork is emphasized. Recommendations for future directions for advanced practice nursing education are offered.

How novice, skilled and advanced clinical researchers include variables in a case report form for clinical research: a qualitative study

PubMed Central

Chu, Hongling; Zeng, Lin; Fetters, Micheal D; Li, Nan; Tao, Liyuan; Shi, Yanyan; Zhang, Hua; Wang, Xiaoxiao; Li, Fengwei; Zhao, Yiming

2017-01-01

Objectives Despite varying degrees in research training, most academic clinicians are expected to conduct clinical research. The objective of this research was to understand how clinical researchers of different skill levels include variables in a case report form for their clinical research. Setting The setting for this research was a major academic institution in Beijing, China. Participants The target population was clinical researchers with three levels of experience, namely, limited clinical research experience, clinicians with rich clinical research experience and clinical research experts. Methods Using a qualitative approach, we conducted 13 individual interviews (face to face) and one group interview (n=4) with clinical researchers from June to September 2016. Based on maximum variation sampling to identify researchers with three levels of research experience: eight clinicians with limited clinical research experience, five clinicians with rich clinical research experience and four clinical research experts. These 17 researchers had diverse hospital-based medical specialties and or specialisation in clinical research. Results Our analysis yields a typology of three processes developing a case report form that varies according to research experience level. Novice clinician researchers often have an incomplete protocol or none at all, and conduct data collection and publication based on a general framework. Experienced clinician researchers include variables in the case report form based on previous experience with attention to including domains or items at risk for omission and by eliminating unnecessary variables. Expert researchers consider comprehensively in advance data collection and implementation needs and plan accordingly. Conclusion These results illustrate increasing levels of sophistication in research planning that increase sophistication in selection for variables in the case report form. These findings suggest that novice and intermediate

Continuous analogues of matrix factorizations

PubMed Central

Townsend, Alex; Trefethen, Lloyd N.

2015-01-01

Analogues of singular value decomposition (SVD), QR, LU and Cholesky factorizations are presented for problems in which the usual discrete matrix is replaced by a ‘quasimatrix’, continuous in one dimension, or a ‘cmatrix’, continuous in both dimensions. Two challenges arise: the generalization of the notions of triangular structure and row and column pivoting to continuous variables (required in all cases except the SVD, and far from obvious), and the convergence of the infinite series that define the cmatrix factorizations. Our generalizations of triangularity and pivoting are based on a new notion of a ‘triangular quasimatrix’. Concerning convergence of the series, we prove theorems asserting convergence provided the functions involved are sufficiently smooth. PMID:25568618

Improvement in latent variable indirect response joint modeling of a continuous and a categorical clinical endpoint in rheumatoid arthritis.

PubMed

Hu, Chuanpu; Zhou, Honghui

2016-02-01

Improving the quality of exposure-response modeling is important in clinical drug development. The general joint modeling of multiple endpoints is made possible in part by recent progress on the latent variable indirect response (IDR) modeling for ordered categorical endpoints. This manuscript aims to investigate, when modeling a continuous and a categorical clinical endpoint, the level of improvement achievable by joint modeling in the latent variable IDR modeling framework through the sharing of model parameters for the individual endpoints, guided by the appropriate representation of drug and placebo mechanism. This was illustrated with data from two phase III clinical trials of intravenously administered mAb X for the treatment of rheumatoid arthritis, with the 28-joint disease activity score (DAS28) and 20, 50, and 70% improvement in the American College of Rheumatology (ACR20, ACR50, and ACR70) disease severity criteria were used as efficacy endpoints. The joint modeling framework led to a parsimonious final model with reasonable performance, evaluated by visual predictive check. The results showed that, compared with the more common approach of separately modeling the endpoints, it is possible for the joint model to be more parsimonious and yet better describe the individual endpoints. In particular, the joint model may better describe one endpoint through subject-specific random effects that would not have been estimable from data of this endpoint alone.

Recent advances in satellite observations of solar variability and global atmospheric ozone

NASA Technical Reports Server (NTRS)

Heath, D. F.

1974-01-01

A description is given of the temporal behavior of the sun as an ultraviolet variable star in relation to daily zonal means of atmospheric ozone from the total amount to that above the 10-mb and 4-mb pressure levels. A significant correlation has been observed between enhancements in the ultraviolet solar irradiances and terrestrial passages of the solar magnetic field sector boundary structure. However, it has not yet been possible to separate solar from the dynamical effects on the variability in the zonal means of ozone. Attention is given to global changes in ozone which have been derived from the satellite observations in terms of season, solar variability, and major stratospheric disturbances such as stratospheric warmings.

Automatic braking system modification for the Advanced Transport Operating Systems (ATOPS) Transportation Systems Research Vehicle (TSRV)

NASA Technical Reports Server (NTRS)

Coogan, J. J.

1986-01-01

Modifications were designed for the B-737-100 Research Aircraft autobrake system hardware of the Advanced Transport Operating Systems (ATOPS) Program at Langley Research Center. These modifications will allow the on-board flight control computer to control the aircraft deceleration after landing to a continuously variable level for the purpose of executing automatic high speed turn-offs from the runway. A bread board version of the proposed modifications was built and tested in simulated stopping conditions. Test results, for various aircraft weights, turnoff speed, winds, and runway conditions show that the turnoff speeds are achieved generally with errors less than 1 ft/sec.

Developing a Model of Advanced Training to Promote Career Advancement for Certified Genetic Counselors: An Investigation of Expanded Skills, Advanced Training Paths, and Professional Opportunities.

PubMed

Baty, Bonnie J; Trepanier, Angela; Bennett, Robin L; Davis, Claire; Erby, Lori; Hippman, Catriona; Lerner, Barbara; Matthews, Anne; Myers, Melanie F; Robbins, Carol B; Singletary, Claire N

2016-08-01

There are currently multiple paths through which genetic counselors can acquire advanced knowledge and skills. However, outside of continuing education opportunities, there are few formal training programs designed specifically for the advanced training of genetic counselors. In the genetic counseling profession, there is currently considerable debate about the paths that should be available to attain advanced skills, as well as the skills that might be needed for practice in the future. The Association of Genetic Counseling Program Directors (AGCPD) convened a national committee, the Committee on Advanced Training for Certified Genetic Counselors (CATCGC), to investigate varied paths to post-master's training and career development. The committee began its work by developing three related grids that view career advancement from the viewpoints of the skills needed to advance (skills), ways to obtain these skills (paths), and existing genetic counselor positions that offer career change or advancement (positions). Here we describe previous work related to genetic counselor career advancement, the charge of the CATCGC, our preliminary work in developing a model through which to view genetic counselor advanced training and career advancement opportunities, and our next steps in further developing and disseminating the model.

The Climate Variability & Predictability (CVP) Program at NOAA - Recent Program Advancements

NASA Astrophysics Data System (ADS)

Lucas, S. E.; Todd, J. F.

2015-12-01

The Climate Variability & Predictability (CVP) Program supports research aimed at providing process-level understanding of the climate system through observation, modeling, analysis, and field studies. This vital knowledge is needed to improve climate models and predictions so that scientists can better anticipate the impacts of future climate variability and change. To achieve its mission, the CVP Program supports research carried out at NOAA and other federal laboratories, NOAA Cooperative Institutes, and academic institutions. The Program also coordinates its sponsored projects with major national and international scientific bodies including the World Climate Research Programme (WCRP), the International and U.S. Climate Variability and Predictability (CLIVAR/US CLIVAR) Program, and the U.S. Global Change Research Program (USGCRP). The CVP program sits within NOAA's Climate Program Office (http://cpo.noaa.gov/CVP). The CVP Program currently supports multiple projects in areas that are aimed at improved representation of physical processes in global models. Some of the topics that are currently funded include: i) Improved Understanding of Intraseasonal Tropical Variability - DYNAMO field campaign and post -field projects, and the new climate model improvement teams focused on MJO processes; ii) Climate Process Teams (CPTs, co-funded with NSF) with projects focused on Cloud macrophysical parameterization and its application to aerosol indirect effects, and Internal-Wave Driven Mixing in Global Ocean Models; iii) Improved Understanding of Tropical Pacific Processes, Biases, and Climatology; iv) Understanding Arctic Sea Ice Mechanism and Predictability;v) AMOC Mechanisms and Decadal Predictability Recent results from CVP-funded projects will be summarized. Additional information can be found at http://cpo.noaa.gov/CVP.

Leaving Welfare: Independence or Continued Vulnerability?

ERIC Educational Resources Information Center

Litt, Jacquelyn; Gaddis, Barbara J.; Fletcher, Cynthia Needles; Winter, Mary

2000-01-01

Interviews with seven women before and 6 months after leaving welfare revealed barriers to self-sufficiency (low wages, lack of advancement opportunities in jobs, confusion about program regulations) and survival strategies (continued reliance on income and family support, banking of care benefits under the 5-year limit as a safety net). (SK)

Entanglement transfer from two-mode continuous variable SU(2) cat states to discrete qubits systems in Jaynes-Cummings Dimers

PubMed Central

Ran, Du; Hu, Chang-Sheng; Yang, Zhen-Biao

2016-01-01

We study the entanglement transfer from a two-mode continuous variable system (initially in the two-mode SU(2) cat states) to a couple of discrete two-state systems (initially in an arbitrary mixed state), by use of the resonant Jaynes-Cummings (JC) interaction. We first quantitatively connect the entanglement transfer to non-Gaussianity of the two-mode SU(2) cat states and find a positive correlation between them. We then investigate the behaviors of the entanglement transfer and find that it is dependent on the initial state of the discrete systems. We also find that the largest possible value of the transferred entanglement exhibits a variety of behaviors for different photon number as well as for the phase angle of the two-mode SU(2) cat states. We finally consider the influences of the noise on the transferred entanglement. PMID:27553881

Numerical simulation of the optimal two-mode attacks for two-way continuous-variable quantum cryptography in reverse reconciliation

NASA Astrophysics Data System (ADS)

Zhang, Yichen; Li, Zhengyu; Zhao, Yijia; Yu, Song; Guo, Hong

2017-02-01

We analyze the security of the two-way continuous-variable quantum key distribution protocol in reverse reconciliation against general two-mode attacks, which represent all accessible attacks at fixed channel parameters. Rather than against one specific attack model, the expression of secret key rates of the two-way protocol are derived against all accessible attack models. It is found that there is an optimal two-mode attack to minimize the performance of the protocol in terms of both secret key rates and maximal transmission distances. We identify the optimal two-mode attack, give the specific attack model of the optimal two-mode attack and show the performance of the two-way protocol against the optimal two-mode attack. Even under the optimal two-mode attack, the performances of two-way protocol are still better than the corresponding one-way protocol, which shows the advantage of making double use of the quantum channel and the potential of long-distance secure communication using a two-way protocol.

Instrumental Variable Methods for Continuous Outcomes That Accommodate Nonignorable Missing Baseline Values.

PubMed

Ertefaie, Ashkan; Flory, James H; Hennessy, Sean; Small, Dylan S

2017-06-15

Instrumental variable (IV) methods provide unbiased treatment effect estimation in the presence of unmeasured confounders under certain assumptions. To provide valid estimates of treatment effect, treatment effect confounders that are associated with the IV (IV-confounders) must be included in the analysis, and not including observations with missing values may lead to bias. Missing covariate data are particularly problematic when the probability that a value is missing is related to the value itself, which is known as nonignorable missingness. In such cases, imputation-based methods are biased. Using health-care provider preference as an IV method, we propose a 2-step procedure with which to estimate a valid treatment effect in the presence of baseline variables with nonignorable missing values. First, the provider preference IV value is estimated by performing a complete-case analysis using a random-effects model that includes IV-confounders. Second, the treatment effect is estimated using a 2-stage least squares IV approach that excludes IV-confounders with missing values. Simulation results are presented, and the method is applied to an analysis comparing the effects of sulfonylureas versus metformin on body mass index, where the variables baseline body mass index and glycosylated hemoglobin have missing values. Our result supports the association of sulfonylureas with weight gain. © The Author 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Continuously Variable Transmission

NASA Technical Reports Server (NTRS)

Grana, D. C.

1985-01-01

Chain slides along two cones, in novel transmission concept. Transmission includes chain drive between two splined shafts. Chain sprockets follow surfaces of two cones. As one chain sprocket moves toward smaller diameter other chain sprocket moves toward larger diameter, thereby changing "gear" ratio. Movement initiated by tension applied to chain by planetary gear mechanism. Device positive, simple, and efficient over wide range of speed ratios.

Learning Styles in Continuing Medical Education.

ERIC Educational Resources Information Center

Bennet, Nancy L.; Fox, Robert D.

1984-01-01

Synthesizes literature on cognitive style and considers issues about its role in continuing medical education research, including whether it should be used as a dependent or independent variable and how it may be used in causal models. (SK)

Classification of Innovation Objectives Set for Continuing Professional Teacher Development

ERIC Educational Resources Information Center

Tyunnikov, Yurii S.

2017-01-01

The present demand for teachers, showing advanced aptitude for innovations, is an important reason for promotion of innovative practices in the continuous teacher training. For the on-going development of a continuous training system preparing teachers for innovative activities, it is necessary to have a complete taxonomy of practical objectives.…

Variable-cycle engines for supersonic cruise aircraft

NASA Technical Reports Server (NTRS)

Willis, E.

1976-01-01

Progress and the current status of the Variable Cycle Engine (VCE) study are reviewed with emphasis placed on the impact of technology advancements and design specifications. A large variety of VCE concepts are also examined.

Advanced intensity-modulation continuous-wave lidar techniques for ASCENDS CO2 column measurements

NASA Astrophysics Data System (ADS)

Campbell, Joel F.; Lin, Bing; Nehrir, Amin R.; Harrison, F. W.; Obland, Michael D.; Meadows, Byron

2015-10-01

Global atmospheric carbon dioxide (CO2) measurements for the NASA Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) space mission are critical for improving our understanding of global CO2 sources and sinks. Advanced Intensity- Modulated Continuous-Wave (IM-CW) lidar techniques are investigated as a means of facilitating CO2 measurements from space to meet the ASCENDS measurement requirements. In recent numerical, laboratory and flight experiments we have successfully used the Binary Phase Shift Keying (BPSK) modulation technique to uniquely discriminate surface lidar returns from intermediate aerosol and cloud contamination. We demonstrate the utility of BPSK to eliminate sidelobes in the range profile as a means of making Integrated Path Differential Absorption (IPDA) column CO2 measurements in the presence of optically thin clouds, thereby eliminating the need to correct for sidelobe bias errors caused by the clouds. Furthermore, high accuracy and precision ranging to the surface as well as to the top of intermediate cloud layers, which is a requirement for the inversion of column CO2 number density measurements to column CO2 mixing ratios, has been demonstrated using new hyperfine interpolation techniques that takes advantage of the periodicity of the modulation waveforms. This approach works well for both BPSK and linear swept-frequency modulation techniques. The BPSK technique under investigation has excellent auto-correlation properties while possessing a finite bandwidth. A comparison of BPSK and linear swept-frequency is also discussed in this paper. These results are extended to include Richardson-Lucy deconvolution techniques to extend the resolution of the lidar beyond that implied by limit of the bandwidth of the modulation, where it is shown useful for making tree canopy measurements.

Advanced Intensity-Modulation Continuous-Wave Lidar Techniques for ASCENDS O2 Column Measurements

NASA Technical Reports Server (NTRS)

Campbell, Joel F.; Lin, Bing; Nehrir, Amin R.; Harrison, F. Wallace; Obland, Michael D.; Meadows, Byron

2015-01-01

Global atmospheric carbon dioxide (CO2) measurements for the NASA Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) space mission are critical for improving our understanding of global CO2 sources and sinks. Advanced Intensity- Modulated Continuous-Wave (IM-CW) lidar techniques are investigated as a means of facilitating CO2 measurements from space to meet the ASCENDS measurement requirements. In recent numerical, laboratory and flight experiments we have successfully used the Binary Phase Shift Keying (BPSK) modulation technique to uniquely discriminate surface lidar returns from intermediate aerosol and cloud contamination. We demonstrate the utility of BPSK to eliminate sidelobes in the range profile as a means of making Integrated Path Differential Absorption (IPDA) column CO2 measurements in the presence of optically thin clouds, thereby eliminating the need to correct for sidelobe bias errors caused by the clouds. Furthermore, high accuracy and precision ranging to the surface as well as to the top of intermediate cloud layers, which is a requirement for the inversion of column CO2 number density measurements to column CO2 mixing ratios, has been demonstrated using new hyperfine interpolation techniques that takes advantage of the periodicity of the modulation waveforms. This approach works well for both BPSK and linear swept-frequency modulation techniques. The BPSK technique under investigation has excellent auto-correlation properties while possessing a finite bandwidth. A comparison of BPSK and linear swept-frequency is also discussed in this paper. These results are extended to include Richardson-Lucy deconvolution techniques to extend the resolution of the lidar beyond that implied by limit of the bandwidth of the modulation, where it is shown useful for making tree canopy measurements.

Nanocellulose in spun continuous fibers: A review and future outlook

Treesearch

Craig Clemons

2016-01-01

Continuous fibers are commonly manufactured for a wide variety of uses such as filters, textiles, and composites. For example, most fibrous reinforcements (e.g., carbon fiber, glass fiber) for advanced composites are continuous fibers or yarns, fabrics, and preforms made from them. This allows broad flexibility in design and manufacturing approaches by controlling...

Experimental and analytical investigations of longitudinal combustion instability in a continuously variable resonance combustor (CVRC)

NASA Astrophysics Data System (ADS)

Yu, Yen Ching

An analytical model based on linearized Euler equations (LEE) is developed and used in conjunction with a validating experiment to study combustion instability. The LEE model features mean flow effects, entropy waves, adaptability for more physically-realistic boundary conditions, and is generalized for multiple-domain conditions. The model calculates spatial modes, resonant frequencies and linear growth rates of the overall system. The predicted resonant frequencies and spatially-resolved mode shapes agree with the experimental data from a longitudinally-unstable model rocket combustor to within 7%. Different gaseous fuels (methane, ethylene, and hydrogen) were tested under fixed geometry. Tests with hydrogen were stable, whereas ethylene, methane, and JP-8 were increasingly unstable. A novel method for obtaining large amounts of stability data under variable resonance conditions in a single test was demonstrated. The continuously variable resonance combustor (CVRC) incorporates a traversing choked axial oxidizer inlet to vary the overall combustion system resonance. The CVRC experiment successfully demonstrates different level of instability, transitions between stability levels, and identifies the most stable and unstable geometric combination. Pressure oscillation amplitudes ranged from less than 10% of mean pressure to greater than 60%. At low amplitudes, measured resonant frequency changed with inlet location but at high amplitude the measured resonance frequency matched the frequency of the combustion chamber. As the system transitions from linear to non-linear instability, the higher harmonics of the fundamental resonant mode appear nearly simultaneously. Transient, high-amplitude, broadband noise, at lower frequencies (on the order of 200 Hz) are also observed. Conversely, as the system transitions back to a more linear stability regime, the higher harmonics disappear sequentially, led by the highest order. Good agreements between analytical and

Confirming LBV Candidates Through Variability: A Photometric and Spectroscopic Monitoring Study

NASA Astrophysics Data System (ADS)

Stringfellow, Guy; Gvaramadze, Vasilii

2013-02-01

Luminous Blue Variable (LBV) stars represent an extremely rare class of luminous massive stars with high mass loss rates. The paucity ( 12) of confirmed Galactic LBV precludes determining a solid evolutionary connection between LBV and other intermediate (e.g. Ofpe/WN9, WNL) phases in the life of very massive stars. We've been conducting an optical/near-IR spectral survey of a large subset of central stars residing within newly discovered it Spitzer nebulae and have identified over two dozen new candidate LBVs (cLBVs) based on spectral similarity alone; confirming them as bona fide LBVs requires demonstrating 1-3 mag photometric and spectroscopic variability. This marks a significant advancement in the study of massive stars, far outweighing the return from many studies searching for LBVs and WRs the past several decades. Monitoring from semesters 2011B-2012A already has confirmed one new cLBV as a bona fide LBV. We propose to continue optical-IR photometric monitoring of these cLBVS with the 1.3m. Chiron, replacing the RC spectrograph on the 1.5m, now allows high-resolution optical spectroscopic monitoring of bright cLBVs, 11 of which are proposed herein. Spectra are important for understanding the physics driving photometric variability, properties of the wind, and allow analysis of line profiles.

Advanced downhole periodic seismic generator

DOEpatents

Hardee, Harry C.; Hills, Richard G.; Striker, Richard P.

1991-07-16

An advanced downhole periodic seismic generator system for transmitting variable frequency, predominantly shear-wave vibration into earth strata surrounding a borehole. The system comprises a unitary housing operably connected to a well head by support and electrical cabling and contains clamping apparatus for selectively clamping the housing to the walls of the borehole. The system further comprises a variable speed pneumatic oscillator and a self-contained pneumatic reservoir for producing a frequency-swept seismic output over a discrete frequency range.

Development Of Advanced Welding Control System

NASA Technical Reports Server (NTRS)

1990-01-01

Report describes development of next-generation control system for variable-polarity plasma arc (VPPA) welding. When fully developed, system expected to incorporate advanced sensors and adaptive control of position of and current in welding torch.

Advanced rocket propulsion

NASA Technical Reports Server (NTRS)

Obrien, Charles J.

1993-01-01

Existing NASA research contracts are supporting development of advanced reinforced polymer and metal matrix composites for use in liquid rocket engines of the future. Advanced rocket propulsion concepts, such as modular platelet engines, dual-fuel dual-expander engines, and variable mixture ratio engines, require advanced materials and structures to reduce overall vehicle weight as well as address specific propulsion system problems related to elevated operating temperatures, new engine components, and unique operating processes. High performance propulsion systems with improved manufacturability and maintainability are needed for single stage to orbit vehicles and other high performance mission applications. One way to satisfy these needs is to develop a small engine which can be clustered in modules to provide required levels of total thrust. This approach should reduce development schedule and cost requirements by lowering hardware lead times and permitting the use of existing test facilities. Modular engines should also reduce operational costs associated with maintenance and parts inventories.

High-power disk lasers: advances and applications

NASA Astrophysics Data System (ADS)

Havrilla, David; Ryba, Tracey; Holzer, Marco

2012-03-01

Though the genesis of the disk laser concept dates to the early 90's, the disk laser continues to demonstrate the flexibility and the certain future of a breakthrough technology. On-going increases in power per disk, and improvements in beam quality and efficiency continue to validate the genius of the disk laser concept. As of today, the disk principle has not reached any fundamental limits regarding output power per disk or beam quality, and offers numerous advantages over other high power resonator concepts, especially over monolithic architectures. With about 2,000 high power disk lasers installations, and a demand upwards of 1,000 lasers per year, the disk laser has proven to be a robust and reliable industrial tool. With advancements in running cost, investment cost and footprint, manufacturers continue to implement disk laser technology with more vigor than ever. This paper will explain recent advances in disk laser technology and process relevant features of the laser, like pump diode arrangement, resonator design and integrated beam guidance. In addition, advances in applications in the thick sheet area and very cost efficient high productivity applications like remote welding, remote cutting and cutting of thin sheets will be discussed.

Continuation of the NVAP Global Water Vapor Data Sets for Pathfinder Science Analysis

NASA Technical Reports Server (NTRS)

VonderHaar, Thomas H.; Engelen, Richard J.; Forsythe, John M.; Randel, David L.; Ruston, Benjamin C.; Woo, Shannon; Dodge, James (Technical Monitor)

2001-01-01

This annual report covers August 2000 - August 2001 under NASA contract NASW-0032, entitled "Continuation of the NVAP (NASA's Water Vapor Project) Global Water Vapor Data Sets for Pathfinder Science Analysis". NASA has created a list of Earth Science Research Questions which are outlined by Asrar, et al. Particularly relevant to NVAP are the following questions: (a) How are global precipitation, evaporation, and the cycling of water changing? (b) What trends in atmospheric constituents and solar radiation are driving global climate? (c) How well can long-term climatic trends be assessed or predicted? Water vapor is a key greenhouse gas, and an understanding of its behavior is essential in global climate studies. Therefore, NVAP plays a key role in addressing the above climate questions by creating a long-term global water vapor dataset and by updating the dataset with recent advances in satellite instrumentation. The NVAP dataset produced from 1988-1998 has found wide use in the scientific community. Studies of interannual variability are particularly important. A recent paper by Simpson, et al. that examined the NVAP dataset in detail has shown that its relative accuracy is sufficient for the variability studies that contribute toward meeting NASA's goals. In the past year, we have made steady progress towards continuing production of this high-quality dataset as well as performing our own investigations of the data. This report summarizes the past year's work on production of the NVAP dataset and presents results of analyses we have performed in the past year.

Advanced electromagnetic methods for aerospace vehicles

NASA Technical Reports Server (NTRS)

Balanis, Constantine A.; Sun, Weimin; El-Sharawy, El-Budawy; Aberle, James T.; Birtcher, Craig R.; Peng, Jian; Tirkas, Panayiotis A.

1992-01-01

The Advanced Helicopter Electromagnetics (AHE) Industrial Associates Program continues its research on variety of main topics identified and recommended by the Advisory Task Force of the program. The research activities center on issues that advance technology related to helicopter electromagnetics. While most of the topics are a continuation of previous works, special effort has been focused on some of the areas due to recommendations from the last annual conference. The main topics addressed in this report are: composite materials, and antenna technology. The area of composite materials continues getting special attention in this period. The research has focused on: (1) measurements of the electrical properties of low-conductivity materials; (2) modeling of material discontinuity and their effects on the scattering patterns; (3) preliminary analysis on interaction of electromagnetic fields with multi-layered graphite fiberglass plates; and (4) finite difference time domain (FDTD) modeling of fields penetration through composite panels of a helicopter.

Continuous Symmetry and Chemistry Teachers: Learning Advanced Chemistry Content through Novel Visualization Tools

ERIC Educational Resources Information Center

Tuvi-Arad, Inbal; Blonder, Ron

2010-01-01

In this paper we describe the learning process of a group of experienced chemistry teachers in a specially designed workshop on molecular symmetry and continuous symmetry. The workshop was based on interactive visualization tools that allow molecules and their symmetry elements to be rotated in three dimensions. The topic of continuous symmetry is…

Effects of categorization method, regression type, and variable distribution on the inflation of Type-I error rate when categorizing a confounding variable.

PubMed

Barnwell-Ménard, Jean-Louis; Li, Qing; Cohen, Alan A

2015-03-15

The loss of signal associated with categorizing a continuous variable is well known, and previous studies have demonstrated that this can lead to an inflation of Type-I error when the categorized variable is a confounder in a regression analysis estimating the effect of an exposure on an outcome. However, it is not known how the Type-I error may vary under different circumstances, including logistic versus linear regression, different distributions of the confounder, and different categorization methods. Here, we analytically quantified the effect of categorization and then performed a series of 9600 Monte Carlo simulations to estimate the Type-I error inflation associated with categorization of a confounder under different regression scenarios. We show that Type-I error is unacceptably high (>10% in most scenarios and often 100%). The only exception was when the variable categorized was a continuous mixture proxy for a genuinely dichotomous latent variable, where both the continuous proxy and the categorized variable are error-ridden proxies for the dichotomous latent variable. As expected, error inflation was also higher with larger sample size, fewer categories, and stronger associations between the confounder and the exposure or outcome. We provide online tools that can help researchers estimate the potential error inflation and understand how serious a problem this is. Copyright © 2014 John Wiley & Sons, Ltd.

Continuous engineering of nano-cocrystals for medical and energetic applications

PubMed Central

Spitzer, D.; Risse, B.; Schnell, F.; Pichot, V.; Klaumünzer, M.; Schaefer, M. R.

2014-01-01

Cocrystals, solid mixtures of different molecules on molecular scale, are supposed to be tailor made materials with improved employability compared to their pristine individual components in domains such as medicine and explosives. In medicine, cocrystals are obtained by crystallization of active pharmaceutical ingredients with precisely chosen coformers to design medicaments that demonstrate enhanced stability, high solubility, and therefore high bioavailability and optimized drug up-take. Nanoscaling may further advance these characteristica compared to their micronsized counterparts – because of a larger surface to volume ratio of nanoparticles. In the field of energetic materials, cocrystals offer the opportunity to design smart explosives, combining high reactivity with significantly reduced sensitivity, nowadays essential for a safe manipulation and handling. Furthermore, cocrystals are used in ferroelectrics, non-linear material response and electronic organics. However, state of the art batch processes produce low volume of cocrystals of variable quality and only have produced micronsized cocrystals so far, no nano-cocrystals. Here we demonstrate the continuous preparation of pharmaceutical and energetic micro- and nano-cocrystals using the Spray Flash Evaporation process. Our laboratory scale pilot plant continuously prepared up to 8 grams per hour of Caffeine/Oxalic acid 2:1, Caffeine/Glutaric acid 1:1, TNT/CL-20 1:1 and HMX/Cl-20 1:2 nano- and submicronsized cocrystals. PMID:25300652

Advanced Plant Habitat (APH)

NASA Technical Reports Server (NTRS)

Richards, Stephanie E. (Compiler); Levine, Howard G.; Reed, David W.

2016-01-01

The Advanced Plant Habitat (APH) hardware will be a large growth volume plant habitat, capable of hosting multigenerational studies, in which environmental variables (e.g., temperature, relative humidity, carbon dioxide level light intensity and spectral quality) can be tracked and controlled in support of whole plant physiological testing and Bio-regenerative Life Support System investigations.

38 CFR 36.4511 - Advances after loan closing.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Advances after loan closing. 36.4511 Section 36.4511 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) LOAN GUARANTY Direct Loans § 36.4511 Advances after loan closing. (a) The Department of Veterans...