AmeriFlux US-Bkg Brookings

DOE Data Explorer

Meyers, Tilden [NOAA/ARL

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Bkg Brookings. Site Description - The Brookings site is located in a private pasture, consisting of a mixture of C3 and C4 species actively used for grazing. Belonging to the Northern Great Plains Rangelands, the grassland is representative of many in the north central United States, with seasonal winter conditions and a wet growing season.

Plum Brook Station Open House - 2016

NASA Image and Video Library

2016-06-11

Astronaut Sunita Williams gives a talk at NASA's Plum Brook Station. In June, NASA Glenn hosted an Open House at Plum Brook Station in Sandusky to celebrate the 75th anniversary of the Center. Thousands of people attended, and some lucky kids got to see awesome experiments and meet astronaut Suni Williams.

33 CFR 117.202 - Cold Spring Brook.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Cold Spring Brook. 117.202 Section 117.202 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.202 Cold Spring Brook. The draw of...

33 CFR 117.202 - Cold Spring Brook.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Cold Spring Brook. 117.202 Section 117.202 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.202 Cold Spring Brook. The draw of...

33 CFR 117.202 - Cold Spring Brook.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Cold Spring Brook. 117.202 Section 117.202 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.202 Cold Spring Brook. The draw of...

33 CFR 117.202 - Cold Spring Brook.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Cold Spring Brook. 117.202 Section 117.202 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.202 Cold Spring Brook. The draw of...

33 CFR 117.202 - Cold Spring Brook.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Cold Spring Brook. 117.202 Section 117.202 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.202 Cold Spring Brook. The draw of...

36 CFR 13.1226 - Brooks Falls area.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Brooks Falls area. 13.1226 Section 13.1226 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Katmai National Park and Preserve Brooks Camp...

32 CFR 989.12 - AF Form 813, Request for Environmental Impact Analysis.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false AF Form 813, Request for Environmental Impact... FORCE ENVIRONMENTAL PROTECTION ENVIRONMENTAL IMPACT ANALYSIS PROCESS (EIAP) § 989.12 AF Form 813, Request for Environmental Impact Analysis. The Air Force uses AF Form 813 to document the need for...

Health and Job-Specific Body Composition Standards for the US Air Force. Volume 1

DTIC Science & Technology

2000-01-18

AF/CF-TR-1994-0046). Brooks AFB, TX: Armstrong Laboratory. Pollock, M. L., Garzarella, L., & Graves, J. E. (1995). The measurement of body...T 5/80). Natick, MA: US Army Research Institute of Environmental Medicine. Wang, Z. M., Visser, M., Ma, R., Baumgartner, R. N., Kotler , D

Past and projected future changes in snowpack and soil frost at the Hubbard Brook Experimental Forest, New Hampshire, USA

Treesearch

John L. Campbell; Scott V. Ollinger; Gerald N. Flerchinger; Haley Wicklein; Katharine Hayhoe; Amey S. Bailey

2010-01-01

Long-term data from the Hubbard Brook Experimental Forest in New Hampshire show that air temperature has increased by about 1 °C over the last half century. The warmer climate has caused significant declines in snow depth, snow water equivalent and snow cover duration. Paradoxically, it has been suggested that warmer air temperatures may result in colder soils...

THE BEAR BROOK WATERSHED MANIPULATION PROJECT: WATERSHED SCIENCE IN A POLICY PERSPECTIVE

EPA Science Inventory

The Bear Brook Watershed Manipulation in Maine is a paired watershed experiment. Monitoring of the paired catchments (East Bear Brook - reference; West Bear Brook - experimental) began in early 1987. Chemical manipulation of West Bear Brook catchment began in November 1989. Proce...

AmeriFlux US-Br1 Brooks Field Site 10- Ames

DOE Data Explorer

Parkin, Tim [USDA; Prueger, John [National Laboratory for Agriculture and the Environment

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Br1 Brooks Field Site 10- Ames. Site Description - The Brooks Field Site 10 - Ames Site is one of three sites (Brooks Field Site 11 and Brooks Field Site 1011) located in a corn/soybean agricultural landscape of central Iowa. The farming systems, associated tillage, and nutrient management practices for soybean/corn production are typical of those throughout Upper Midwest Corn Belt. All three sites are members of the AmeriFlux network. Information for all three can be found in synchronous pages of this website.

AmeriFlux US-Br3 Brooks Field Site 11- Ames

DOE Data Explorer

Parkin, Tim [USDA; Prueger, John [National Laboratory for Agriculture and the Environment

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Br3 Brooks Field Site 11- Ames. Site Description - The Brooks Field Site 11 - Ames Site is one of three sites (Brooks Field Site 10 and Brooks Field Site 1011) located in a corn/soybean agricultural landscape of central Iowa. The farming systems, associated tillage, and nutrient management practices for soybean/corn production are typical of those throughout Upper Midwest Corn Belt. All three sites are members of the AmeriFlux network. Information for all three can be found in synchronous pages of this website.

Hydraulic modeling of stream channels and structures in Harbor and Crow Hollow Brooks, Meriden, Connecticut

USGS Publications Warehouse

Weiss, Lawrence A.; Sears, Michael P.; Cervione, Michael A.

1994-01-01

Effects of urbanization have increased the frequency and size of floods along certain reaches of Harbor Brook and Crow Hollow Brook in Meriden, Conn. A floodprofile-modeling study was conducted to model the effects of selected channel and structural modifications on flood elevations and inundated areas. The study covered the reach of Harbor Brook downstream from Interstate 691 and the reach of Crow Hollow Brook downstream from Johnson Avenue. Proposed modifications, which include changes to bank heights, channel geometry, structural geometry, and streambed armoring on Harbor Brook and changes to bank heights on Crow Hollow Brook, significantly lower flood elevations. Results of the modeling indicate a significant reduction of flood elevations for the 10-year, 25-year, 35-year, 50-year, and 100-year flood frequencies using proposed modifications to (1 ) bank heights between Harbor Brook Towers and Interstate 691 on Harbor Brook, and between Centennial Avenue and Johnson Avenue on Crow Hollow Brook; (2) channel geometry between Coe Avenue and Interstate 69 1 on Harbor Brook; (3) bridge and culvert opening geometry between Harbor Brook Towers and Interstate 691 on Harbor Brook; and (4) channel streambed armoring between Harbor Brook Towers and Interstate 691 on Harbor Brook. The proposed modifications were developed without consideration of cost-benefit ratios.

Ranking site vulnerability to increasing temperatures in southern Appalachian brook trout streams in Virginia: An exposure-sensitivity approach

Treesearch

Bradly A. Trumbo; Keith H. Nislow; Jonathan Stallings; Mark Hudy; Eric P. Smith; Dong-Yun Kim; Bruce Wiggins; Charles A. Dolloff

2014-01-01

Models based on simple air temperature–water temperature relationships have been useful in highlighting potential threats to coldwater-dependent species such as Brook Trout Salvelinus fontinalis by predicting major losses of habitat and substantial reductions in geographic distribution. However, spatial variability in the relationship between changes...

Modeling the Impact of Cracking in Low Permeability Layers in a Groundwater Contamination Source Zone on Dissolved Contaminant Fate and Transport

DTIC Science & Technology

2012-03-22

Approved: //signed// 14 Mar 2011 __________________________________ _________ Mark N. Goltz , Ph.D... Goltz for providing me the opportunity to work together on this research. The discussions, timely edits, and encouragement were greatly...Zone Initiative Final Report. Brooks AF Base: US Air Force, 2007. Aryal, D., M. Otera, A. Demond, M. Goltz , and J. Huang. Impact of Chlorinated

Organisms of the Hubbard Brook Valley, New Hampshire

Treesearch

Richard T. Holmes; Gene E. Likens

1999-01-01

Lists the organisms, both plant and animal, that have been identified by scientists engaged in multidisciplinary ecological research in the Hubbard Brook Valley, New Hampshire, during the past three decades. The Valley encompasses the Hubbard Brook Experimental Forest, Mirror Lake, and nearby areas within the White Mountain region of Grafton County. The species lists...

Movements of nonnative brook trout in relation to stream channel slope

Treesearch

Susan B. Adams; Christopher A. Frissell; Bruce E. Rieman

2000-01-01

Abstract.We provide new insights on the ability of naturalized brook trout Salvelinus fontinalis to ascend steep, headwater streams in the western USA. We tested hypotheses that upstream movements by brook trout are limited or absent in reaches of steep streams and are more prevalent and longer in gradually sloping streams. We compared brook trout...

Brooks Grease Service, Inc.

EPA Pesticide Factsheets

The EPA is providing notice of a proposed Administrative Penalty Assessment against Brooks Grease Service, Inc., for alleged violations at its vegetable oil collection and storage facility located at or near 218 East James St., Kansas City, KS 66118.

Botanical reconnaissance of Nancy Brook Research Natural Area

Treesearch

Joshua L. Royte; Daniel D. Sperduto; John P. Lortie

1996-01-01

A survey of the flora and natural communities of Nancy Brook Research Natural Area, Crawford Notch, White Mountain National Forest, New Hampshire, was conducted during the summer and fall of 1992. Nancy Brook Research Natural Area is noted for being the largest virgin mountain spruce forest in New Hampshire, and one of the few remaining large examples in the...

Air Mobility Command > Home

Science.gov Websites

U.S. Air Force AF Week in Photos Senior leaders meet with industry to discuss utilizing artificial intelligence and quantum science throughout the Air Force AF announces 2018 Blacks in Government Meritorious

Epidemoligic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides: Baseline Questionnaires

DTIC Science & Technology

1982-11-01

19M I Prepared for: The Surgeon General ~, United States Air Force Washington, D.C. 20314 USAF SCHOOL OF AEROSPACE MEDICINE Brooks Air Force Base...School of Aerospace Medicine , Aerospace Medical Division, AFSC, Brooks Air Force Base, Texas, under job order 2767-00-01. la When Government drawings...Wolfe. Ljeujenant; Colonel, USAF. M C S F. IlFONMING ORGANIZATION NAMS AND AODRESS 10. PROGRAM ELEMENT. PROJECT, TASKUSAF School of Aerospace Medicine

Pre-clinical laboratory evaluation of the new 'AF' arterial line filter range.

PubMed

Yarham, Gemma; Mulholland, John

2010-07-01

The presence of emboli was recognised relatively early in the history of open heart surgery. The emboli produced during cardiopulmonary bypass have the predisposition to distribute into, and ultimately obstruct, microvessels of all tissues. The Sorin Group has recently developed a new range of arterial line filters. Before the Sorin AF range of filters was released for pre-launch clinical trials, our group performed in vitro laboratory testing of the AF range against a selection of commercially available filters on the global market. The Sorin AF620 and AF640 demonstrate both the smallest prime volume and smallest surface contact area (92ml and 290 cm(2), respectively).The results of the GME Handling Efficiency experiments ranged by 39.6%, from 95.9% to 56.3%. In terms of an air bolus handling, the results of the Limit Bolus experiment ranged by 97 ml, from 147.5 ml down to 50 ml. The pressure drop across all the filters was measured under steady state experimental conditions. All of the above investigations were considered against surface area and prime volume. It is clear from the results that some commercially available arterial line filters perform better than others, not only in overall performance, but also with regard to individual characteristics. Evaluating arterial line filters for hospital-specific use has to balance pressure drop, surface area, micro air handling, prime volume and gross air handling; all points need to be considered. In the AF620 and AF640, Sorin boast that they are the two smallest prime and smallest surface area filters commercially available on the global market. The Sorin AF filter range performs well in all of the areas we investigated and will be a competitive option for centres, irrespective of which characteristics they use to evaluate and select their arterial line filter.

Reframing Romaine Brooks' heroic queer modernism.

PubMed

Langer, Cassandra L

2010-01-01

Modernism was not a wholesale embracing of Greenberg's definition as abstracting, non-objective, and autonomous. The expatriate U.S. artist and lesbian Romaine Brooks politicized her portraits of females based on a queer combination of the Byronic erotic and Baudelaire's modern dandy. Her execution of her queer modernist aesthetics re-presents female heroes as part of a self-reflective dynamic of lesbian modernity that emphasizes the ambiguity of normative gender binaries and plays with style, personality, and impersonation as disrupting to bourgeoisie mores. My focus is on how Brooks shatters normative conventions of portraiture in her revolutionary critique of heteronormativity.

27. "SITE PLAN." Specifications No. OC15775, Drawing No. AF600915, sheet ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

27. "SITE PLAN." Specifications No. OC1-57-75, Drawing No. AF-60-09-15, sheet 1 of 96, D.O. Series No. AF 1394/20, Rev. B. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 5296 Rev. B, Date: 11/17/59. Site plan of 20,000-foot track, including construction phasing notes. - Edwards Air Force Base, South Base Sled Track, Edwards Air Force Base, North of Avenue B, between 100th & 140th Streets East, Lancaster, Los Angeles County, CA

Broad-scale patterns of Brook Trout responses to introduced Brown Trout in New York

USGS Publications Warehouse

McKenna, James E.; Slattery, Michael T.; Kean M. Clifford,

2013-01-01

Brook Trout Salvelinus fontinalis and Brown Trout Salmo trutta are valuable sport fish that coexist in many parts of the world due to stocking introductions. Causes for the decline of Brook Trout within their native range are not clear but include competition with Brown Trout, habitat alteration, and repetitive stocking practices. New York State contains a large portion of the Brook Trout's native range, where both species are maintained by stocking and other management actions. We used artificial neural network models, regression, principal components analysis, and simulation to evaluate the effects of Brown Trout, environmental conditions, and stocking on the distribution of Brook Trout in the center of their native range. We found evidence for the decline of Brook Trout in the presence of Brown Trout across many watersheds; 22% of sampled reaches where both species were expected to occur contained only Brown Trout. However, a model of the direct relationship between Brook Trout and Brown Trout abundance explained less than 1% of data variation. Ordination showed extensive overlap of Brook Trout and Brown Trout habitat conditions, with only small components of the hypervolume (multidimensional space) being distinctive. Subsequent analysis indicated higher abundances of Brook Trout in highly forested areas, while Brown Trout were more abundant in areas with relatively high proportions of agriculture. Simulation results indicated that direct interactions and habitat conditions were relatively minor factors compared with the effects of repeated stocking of Brown Trout into Brook Trout habitat. Intensive annual stocking of Brown Trout could eliminate resident Brook Trout in less than a decade. Ecological differences, harvest behavior, and other habitat changes can exacerbate Brook Trout losses. Custom stocking scenarios with Brown Trout introductions at relatively low proportions of resident Brook Trout populations may be able to sustain healthy populations of both

Past and projected future changes in snowpack and soil frost at the Hubbard Brook Experimental Forest, New Hampshire, USA

USDA-ARS?s Scientific Manuscript database

Long-term data from the Hubbard Brook Experimental Forest in New Hampshire show that air temperature has increased by about 1 °C over the last half century. The warmer climate has caused significant declines in snow depth, snow water equivalent, and snow cover duration. Paradoxically, it has been su...

Spatial and temporal movement dynamics of brook Salvelinus fontinalis and brown trout Salmo trutta

USGS Publications Warehouse

Davis, L.A.; Wagner, Tyler; Barton, Meredith L.

2015-01-01

Native eastern brook trout Salvelinus fontinalis and naturalized brown trout Salmo trutta occur sympatrically in many streams across the brook trout’s native range in the eastern United States. Understanding within- among-species variability in movement, including correlates of movement, has implications for management and conservation. We radio tracked 55 brook trout and 45 brown trout in five streams in a north-central Pennsylvania, USA watershed to quantify the movement of brook trout and brown trout during the fall and early winter to (1) evaluate the late-summer, early winter movement patterns of brook trout and brown trout, (2) determine correlates of movement and if movement patterns varied between brook trout and brown trout, and (3) evaluate genetic diversity of brook trout within and among study streams, and relate findings to telemetry-based observations of movement. Average total movement was greater for brown trout (mean ± SD = 2,924 ± 4,187 m) than for brook trout (mean ± SD = 1,769 ± 2,194 m). Although there was a large amount of among-fish variability in the movement of both species, the majority of movement coincided with the onset of the spawning season, and a threshold effect was detected between stream flow and movement: where movement increased abruptly for both species during positive flow events. Microsatellite analysis of brook trout revealed consistent findings to those found using radio-tracking, indicating a moderate to high degree of gene flow among brook trout populations. Seasonal movement patterns and the potential for relatively large movements of brook and brown trout highlight the importance of considering stream connectivity when restoring and protecting fish populations and their habitats.

Installation Restoration Program. Phase II. Confirmation/Quantification. Stage I. Tyndall Air Force Base, Florida.

DTIC Science & Technology

1984-08-01

10 31984 . PREPARED FOR UNITED STATES AIR FORCE OCCUPATIONAL AND ENVIRONMENTAL HEALTH LABORATORY BROOKS AIR FORCE BASE, TEXAS 78235 ,,c.’p! ed di...Force August 1984 Occupational and Environmental Health Laboratory I3 NUMBER OF PAGES Aerospace Medical Division (AFSC) 249 total pages• ~~Brooks Air...PROGRAM BACKGROUND i-I 1.2 FACILITY HISTORY 1-3 1.3 DISPOSAL SITE DESCRIPTIONS 1-b 1.4 PROJECT STAFF 1-20 2.0 ENVIRONMENTAL SETTING 2-1 2.1 METEOROLOGY 2-1

Seasonal habitat use of brook trout and juvenile steelhead in a Lake Ontario tributary

USGS Publications Warehouse

Johnson, James H.; Abbett, Ross; Chalupnicki, Marc A.; Verdoliva, Francis

2016-01-01

Brook trout (Salvelinus fontinalis) are generally restricted to headwaters in New York tributaries of Lake Ontario. In only a few streams are brook trout abundant in lower stream reaches that are accessible to adult Pacific salmonids migrating from the lake. Consequently, because of the rarity of native brook trout populations in these lower stream reaches it is important to understand how they use stream habitat in sympatry with juvenile Pacific salmonids which are now naturalized in several Lake Ontario tributaries. In this study, we examined the seasonal (spring, summer, and fall) habitat use of brook trout and juvenile steelhead (Oncorhynchus mykiss) in Hart Brook, a tributary of eastern Lake Ontario. We found interspecific, intraspecific, and seasonal variation in habitat use. Subyearling steelhead were associated with faster water velocities than subyearling brook trout and, overall, had the least habitat similarity to the other salmonid groups examined. Overyearling brook trout and yearling steelhead exhibited the greatest degree of habitat selection and habitat selection by all four salmonid groups was greatest in summer. The availability of pool habitat for overyearling salmonids may pose the largest impediment to these species in Hart Brook.

Environmental Factors Affecting Brook Trout Occurrence in Headwater Stream Segments

Treesearch

Yoichiro Kanno; Benjamin H. Letcher; Ana L. Rosner; Kyle P. O' Neil; Keith H. Nislow

2015-01-01

We analyzed the associations of catchment-scale and riparian-scale environmental factors with occurrence of Brook Trout Salvelinus fontinalis in Connecticut headwater stream segments with catchment areas of 15 < km2. A hierarchical Bayesian approach was applied to a statewide stream survey data set, in which Brook...

River mainstem thermal regimes influence population structuring within an Appalachian brook trout population

USGS Publications Warehouse

Aunins, Aaron W.; Petty, J. Todd; King, Timothy L.; Schilz, Mariya; Mazik, Patricia M.

2015-01-01

Brook trout (Salvelinus fontinalis) often exist as highly differentiated populations, even at small spatial scales, due either to natural or anthropogenic sources of isolation and low rates of dispersal. In this study, we used molecular approaches to describe the unique population structure of brook trout inhabiting the Shavers Fork watershed, located in eastern West Virginia, and contrast it to nearby populations in tributaries of the upper Greenbrier River and North Fork South Branch Potomac Rivers. Bayesian and maximum likelihood clustering methods identified minimal population structuring among 14 collections of brook trout from throughout the mainstem and tributaries of Shavers Fork, highlighting the role of the cold-water mainstem for connectivity and high rates of effective migration among tributaries. In contrast, the Potomac and Greenbrier River collections displayed distinct levels of population differentiation among tributaries, presumably resulting from tributary isolation by warm-water mainstems. Our results highlight the importance of protecting and restoring cold-water mainstem habitats as part of region-wide brook trout conservation efforts. In addition, our results from Shavers Fork provide a contrast to previous genetic studies that characterize Appalachian brook trout as fragmented isolates rather than well-mixed populations. Additional study is needed to determine whether the existence of brook trout as genetically similar populations among tributaries is truly unique and whether connectivity among brook trout populations can potentially be restored within other central Appalachian watersheds.

Movement patterns of Brook Trout in a restored coastal stream system in southern Massachusetts

USGS Publications Warehouse

Snook, Erin L.; Letcher, Benjamin H.; Dubreuil, Todd L.; Zydlewski, Joseph D.; O'Donnell, Matthew J.; Whiteley, Andrew R.; Hurley, Stephen T.; Danylchuk, Andy J.

2016-01-01

Coastal Brook Trout (Salvelinus fontinalis) populations are found from northern Canada to New England. The extent of anadromy generally decreases with latitude, but the ecology and movements of more southern populations are poorly understood. We conducted a 33-month acoustic telemetry study of Brook Trout in Red Brook, MA, and adjacent Buttermilk Bay (marine system) using 16 fixed acoustic receivers and surgically implanting acoustic transmitters in 84 individuals. Tagged Brook Trout used the stream, estuary (50% of individuals) and bay (10% of individuals). Movements into full sea water were brief when occurring. GAMM models revealed that transitions between habitat areas occurred most often in spring and fall. Environmental data suggest that use of the saline environment is limited by summer temperatures in the bay. Movements may also be related to moon phase. Compared to more northern coastal populations of Brook Trout, the Red Brook population appears to be less anadromous overall, yet the estuarine segment of the system may have considerable ecological importance as a food resource.

Spatial and seasonal dynamics of brook trout populations inhabiting a central Appalachian watershed

USGS Publications Warehouse

Petty, J.T.; Lamothe, P.J.; Mazik, P.M.

2005-01-01

We quantified the watershed-scale spatial population dynamics of brook trout Salvelinus fontinalis in the Second Fork, a third-order tributary of Shavers Fork in eastern West Virginia. We used visual surveys, electrofishing, and mark-recapture techniques to quantify brook trout spawning intensity, population density, size structure, and demographic rates (apparent survival and immigration) throughout the watershed. Our analyses produced the following results. Spawning by brook trout was concentrated in streams with small basin areas (i.e., segments draining less than 3 km2), relatively high alkalinity (>10 mg CaCO3/L), and high amounts of instream cover. The spatial distribution of juvenile and small-adult brook trout within the watershed was relatively stable and was significantly correlated with spawning intensity. However, no such relationship was observed for large adults, which exhibited highly variable distribution patterns related to seasonally important habitat features, including instream cover, stream depth and width, and riparian canopy cover. Brook trout survival and immigration rates varied seasonally, spatially, and among size-classes. Differential survival and immigration tended to concentrate juveniles and small adults in small, alkaline streams, whereas dispersal tended to redistribute large adults at the watershed scale. Our results suggest that spatial and temporal variations in spawning, survival, and movement interact to determine the distribution, abundance, and size structure of brook trout populations at a watershed scale. These results underscore the importance of small tributaries for the persistence of brook trout in this watershed and the need to consider watershed-scale processes when designing management plans for Appalachian brook trout populations. ?? Copyright by the American Fisheries Society 2005.

Groundbreaking Ceremony at the NACA's Plum Brook Station

NASA Image and Video Library

1956-09-21

Addison Rothrock, the National Advisory Committee for Aeronautics’s (NACA) Assistant Director of Research, speaks at the groundbreaking ceremony for the Lewis Flight Propulsion Laboratory’s new test reactor at Plum Brook Station. This dedication event was held almost exactly one year after the NACA announced that it would build its $4.5 million nuclear reactor on 500 acres of the army’s 9000-acre Plum Brook Ordnance Works. The site was located in Sandusky, Ohio, approximately 60 miles west of the NACA Lewis laboratory in Cleveland. Lewis Director Raymond Sharp is seated to the left of Rothrock, Congressman Albert Baumhart and NACA Secretary John Victory are to the right. Many government and local officials were on hand for the press conference and ensuing luncheon. In the wake of World War II the military, the Atomic Energy Commission, and the NACA became interested in the use of atomic energy for propulsion and power. A Nuclear Division was established at NACA Lewis in the early 1950s. The division’s request for a 60-megawatt research reactor was approved in 1955. The semi-remote Plum Brook location was selected over 17 other possible sites. Construction of the Plum Brook Reactor Facility lasted five years. By the time of its first trial runs in 1961 the aircraft nuclear propulsion program had been cancelled. The space age had arrived, however, and the reactor would be used to study materials for a nuclear powered rocket.

Evaluation of catch-and-release regulations on Brook Trout in Pennsylvania streams

USGS Publications Warehouse

Jason Detar,; Kristine, David; Wagner, Tyler; Greene, Tom

2014-01-01

In 2004, the Pennsylvania Fish and Boat Commission implemented catch-and-release (CR) regulations on headwater stream systems to determine if eliminating angler harvest would result in an increase in the number of adult (≥100 mm) or large (≥175 mm) Brook Trout Salvelinus fontinalis. Under the CR regulations, angling was permitted on a year-round basis, no Brook Trout could be harvested at any time, and there were no tackle restrictions. A before-after–control-impact design was used to evaluate the experimental regulations. Brook Trout populations were monitored in 16 treatment (CR regulations) and 7 control streams (statewide regulations) using backpack electrofishing gear periodically for up to 15 years (from 1990 to 2003 or 2004) before the implementation of the CR regulations and over a 7–8-year period (from 2004 or 2005 to 2011) after implementation. We used Poisson mixed models to evaluate whether electrofishing catch per effort (CPE; catch/100 m2) of adult (≥100 mm) or large (≥175 mm) Brook Trout increased in treatment streams as a result of implementing CR regulations. Brook Trout CPE varied among sites and among years, and there was no significant effect (increase or decrease) of CR regulations on the CPE of adult or large Brook Trout. Results of our evaluation suggest that CR regulations were not effective at improving the CPE of adult or large Brook Trout in Pennsylvania streams. Low angler use, high voluntary catch and release, and slow growth rates in infertile headwater streams are likely the primary reasons for the lack of response.

Hazardous Waste Cleanup: RBH Dispersions Incorporated in Bound Brook, New Jersey

EPA Pesticide Factsheets

RBH Dispersions, Inc. is located at L-5 Factory Lane in Bound Brook, New Jersey. The site is also known as the former Inmont Bound Brook facility. The site is bounded by Lehigh Valley Railroad to the north, the Port Reading Railroad to the south, and other

Hydraulic complexity metrics for evaluating in-stream brook trout habitat

Treesearch

J. Kozarek; W. Hession; M. ASCE; C. Dolloff; P. Diplas

2010-01-01

A two-dimensional hydraulic model (River2D) was used to investigate the significance of flow complexity on habitat preferences of brook trout (Salvelinus fontinalis) in the high-gradient Staunton River in Shenandoah National Park, Virginia. Two 100-m reaches were modeled where detailed brook trout surveys (10–30-m resolution) have been conducted annually since 1997....

Acute Exposure to Air Pollution Triggers Atrial Fibrillation

PubMed Central

Link, Mark S.; Luttmann-Gibson, Heike; Schwartz, Joel; Mittleman, Murray A.; Wessler, Benjamin; Gold, Diane R.; Dockery, Douglas W.; Laden, Francine

2013-01-01

Objective The aim of the present study is to evaluate the association of air pollution with the onset of atrial fibrillation (AF). Background Air pollution in general and more specifically particulate matter has been associated with cardiovascular events. Although ventricular arrhythmias are traditionally thought to convey the increased cardiovascular risk, AF may also contribute. Methods Patients with dual chamber implantable cardioverter defibrillators (ICDs) were enrolled and followed prospectively. The association of AF onset with air quality including ambient PM2.5, black carbon, sulfate, particle number, NO2, SO2, and O3 in the 24 hours prior to the arrhythmia was examined utilizing a case-crossover analysis. In sensitivity analyses, associations with air pollution between 2 and 48 hours prior to the AF were examined. Results Of 176 patients followed for an average of 1.9 years, 49 patients had 328 episodes of AF lasting ≥ 30 seconds. Positive but nonsignificant associations were found for PM2.5 in the prior 24 hours, but stronger associations were found with shorter exposure windows. The odds of AF increased by 26% (95% CI 8% to 47%) for each 6.0 µg/m3 increase in PM2.5 in the 2 hours prior to the event (p=0.004). The odds of AF was highest at the upper quartile of mean PM2.5. Conclusion Particulate matter was associated with increased odds of AF onset within hours following exposure in patients with known cardiac disease. Air pollution is an acute trigger of AF, likely contributing to the pollution-associated adverse cardiac outcomes observed in epidemiological studies. PMID:23770178

The Official Home Page of the U.S. Air Force

Science.gov Websites

: May 24 Air Force directs one-day operational safety review SecAF LOI SecAF LOI Letter of Intent AF and members using two C-130 and one C-17 training airframes. (U.S. Air Force photo by Richard Eldridge) The Transport Team crew members using two C-130 and one C-17 training airframes. (U.S. Air Force photo by

Delinquent Medical Service Accounts at Brooke Army Medical Center Need Additional Management Oversight

DTIC Science & Technology

2014-08-13

No. DODIG-2014-101 A U G U S T 1 3 , 2 0 1 4 Delinquent Medical Service Accounts at Brooke Army Medical Center Need Additional Management...13 AUG 2014 2. REPORT TYPE 3. DATES COVERED 00-00-2014 to 00-00-2014 4. TITLE AND SUBTITLE Delinquent Medical Service Accounts at Brooke Army...Results in Brief Delinquent Medical Service Accounts at Brooke Army Medical Center Need Additional Management Oversight Visit us at www.dodig.mil

Brook trout use of thermal refugia and foraging habitat influenced by brown trout

USGS Publications Warehouse

Hitt, Nathaniel P.; Snook, Erin; Massie, Danielle L.

2017-01-01

The distribution of native brook trout (Salvelinus fontinalis) in eastern North America is often limited by temperature and introduced brown trout (Salmo trutta), the relative importance of which is poorly understood but critical for conservation and restoration planning. We evaluated effects of brown trout on brook trout behavior and habitat use in experimental streams across increasing temperatures (14–23 °C) with simulated groundwater upwelling zones providing thermal refugia (6–9 °C below ambient temperatures). Allopatric and sympatric trout populations increased their use of upwelling zones as ambient temperatures increased, demonstrating the importance of groundwater as thermal refugia in warming streams. Allopatric brook trout showed greater movement rates and more even spatial distributions within streams than sympatric brook trout, suggesting interference competition by brown trout for access to forage habitats located outside thermal refugia. Our results indicate that removal of introduced brown trout may facilitate native brook trout expansion and population viability in downstream reaches depending in part on the spatial configuration of groundwater upwelling zones.

The Why, What, and Impact of GPA at Oxford Brookes University

ERIC Educational Resources Information Center

Andrews, Matthew

2016-01-01

This paper examines the introduction at Oxford Brookes University of a Grade Point Average (GPA) scheme alongside the traditional honours degree classification. It considers the reasons for the introduction of GPA, the way in which the scheme was implemented, and offers an insight into the impact of GPA at Brookes. Finally, the paper considers…

Home of Air National Guard

Science.gov Websites

Force AF announces changes to Courses 14 and 15 AF announces changes to Courses 14 and 15 AF announces changes to Courses 14 and 15 121st ARW recruiter hits career milestone in record time 121st ARW recruiter Force logistics team named best in the Air Force AF announces changes to Courses 14 and 15 RSS More

Acute exposure to air pollution triggers atrial fibrillation.

PubMed

Link, Mark S; Luttmann-Gibson, Heike; Schwartz, Joel; Mittleman, Murray A; Wessler, Benjamin; Gold, Diane R; Dockery, Douglas W; Laden, Francine

2013-08-27

This study sought to evaluate the association of air pollution with the onset of atrial fibrillation (AF). Air pollution in general and more specifically particulate matter has been associated with cardiovascular events. Although ventricular arrhythmias are traditionally thought to convey the increased cardiovascular risk, AF may also contribute. Patients with dual chamber implantable cardioverter-defibrillators (ICDs) were enrolled and followed prospectively. The association of AF onset with air quality including ambient particulate matter <2.5 μm aerodynamic diameter (PM2.5), black carbon, sulfate, particle number, NO2, SO2, and O3 in the 24 h prior to the arrhythmia was examined utilizing a case-crossover analysis. In sensitivity analyses, associations with air pollution between 2 and 48 h prior to the AF were examined. Of 176 patients followed for an average of 1.9 years, 49 patients had 328 episodes of AF lasting ≥ 30 s. Positive but nonsignificant associations were found for PM2.5 in the prior 24 h, but stronger associations were found with shorter exposure windows. The odds of AF increased by 26% (95% confidence interval: 8% to 47%) for each 6.0 μg/m(3) increase in PM2.5 in the 2 h prior to the event (p = 0.004). The odds of AF were highest at the upper quartile of mean PM2.5. PM was associated with increased odds of AF onset within hours following exposure in patients with known cardiac disease. Air pollution is an acute trigger of AF, likely contributing to the pollution-associated adverse cardiac outcomes observed in epidemiological studies. Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Science in Flux: NASA's Nuclear Program at Plum Brook Station 1955-2005

NASA Technical Reports Server (NTRS)

Bowles, Mark D.

2006-01-01

Science in Flux traces the history of one of the most powerful nuclear test reactors in the United States and the only nuclear facility ever built by NASA. In the late 1950's NASA constructed Plum Brook Station on a vast tract of undeveloped land near Sandusky, Ohio. Once fully operational in 1963, it supported basic research for NASA's nuclear rocket program (NERVA). Plum Brook represents a significant, if largely forgotten, story of nuclear research, political change, and the professional culture of the scientists and engineers who devoted their lives to construct and operate the facility. In 1973, after only a decade of research, the government shut Plum Brook down before many of its experiments could be completed. Even the valiant attempt to redefine the reactor as an environmental analysis tool failed, and the facility went silent. The reactors lay in costly, but quiet standby for nearly a quarter-century before the Nuclear Regulatory Commission decided to decommission the reactors and clean up the site. The history of Plum Brook reveals the perils and potentials of that nuclear technology. As NASA, Congress, and space enthusiasts all begin looking once again at the nuclear option for sending humans to Mars, the echoes of Plum Brook's past will resonate with current policy and space initiatives.

Reducing Air Force Fighter Pilot Shortages

DTIC Science & Technology

2015-12-31

that active-component fighter pilot requirements (particularly nonflying staff requirements) exceed its capacity to train and provide initial...pilots in the reserve components. This research was sponsored by four elements of the U.S. Air Force: the Deputy Chief of Staff for Operations (AF/A3...the Deputy Chief of Staff for Manpower, Personnel and Services (AF/A1); the Commander, Air Force Reserve Command (AFRC/CC); and the Director, Air

Conservation genetics of Lake Superior brook trout: Issues, questions, and directions

USGS Publications Warehouse

Wilson, C.C.; Stott, W.; Miller, L.; D'Amelio, S.; Jennings, Martin J.; Cooper, A.M.

2008-01-01

Parallel efforts by several genetic research groups have tackled common themes relating to management concerns about and recent rehabilitation opportunities for coaster brook trout Salvelinus fontinalis in Lake Superior. The questions that have been addressed include the evolutionary and genetic status of coaster brook trout, the degree of relatedness among coaster populations and their relationship to riverine tributary brook trout populations, and the role and effectiveness of stocking in maintaining and restoring coasters to Lake Superior. Congruent genetic results indicate that coasters are an ecotype (life history variant) rather than an evolutionarily significant unit or genetically distinct strain. Regional structure exists among brook trout stocks, coasters being produced from local populations. Introgression of hatchery genes into wild populations appears to vary regionally and may relate to local population size, habitat integrity, and anthropogenic pressures. Tracking the genetic diversity and integrity associated with captive breeding programs is helping to ensure that the fish used for stocking are representative of their source populations and appropriate for rehabilitation efforts. Comparative analysis of shared samples among collaborating laboratories is enabling standardization of genotype scoring and interpretation as well as the development of a common toolkit for assessing genetic structure and diversity. Incorporation of genetic data into rehabilitation projects will facilitate monitoring efforts and subsequent adaptive management. Together, these multifaceted efforts provide comprehensive insights into the biology of coaster brook trout and enhance restoration options. ?? Copyright by the American Fisheries Society 2008.

Landscape models of brook trout abundance and distribution in lotic habitat with field validation

USGS Publications Warehouse

McKenna, James E.; Johnson, James H.

2011-01-01

Brook trout Salvelinus fontinalis are native fish in decline owing to environmental changes. Predictions of their potential distribution and a better understanding of their relationship to habitat conditions would enhance the management and conservation of this valuable species. We used over 7,800 brook trout observations throughout New York State and georeferenced, multiscale landscape condition data to develop four regionally specific artificial neural network models to predict brook trout abundance in rivers and streams. Land cover data provided a general signature of human activity, but other habitat variables were resistant to anthropogenic changes (i.e., changing on a geological time scale). The resulting models predict the potential for any stream to support brook trout. The models were validated by holding 20% of the data out as a test set and by comparison with additional field collections from a variety of habitat types. The models performed well, explaining more than 90% of data variability. Errors were often associated with small spatial displacements of predicted values. When compared with the additional field collections (39 sites), 92% of the predictions were off by only a single class from the field-observed abundances. Among “least-disturbed” field collection sites, all predictions were correct or off by a single abundance class, except for one where brown trout Salmo trutta were present. Other degrading factors were evident at most sites where brook trout were absent or less abundant than predicted. The most important habitat variables included landscape slope, stream and drainage network sizes, water temperature, and extent of forest cover. Predicted brook trout abundances were applied to all New York streams, providing a synoptic map of the distribution of brook trout habitat potential. These fish models set benchmarks of best potential for streams to support brook trout under broad-scale human influences and can assist with planning and

Seasonal temperature and precipitation regulate brook trout young-of-the-year abundance and population dynamics

USGS Publications Warehouse

Kanno, Yoichiro; Pregler, Kasey C.; Hitt, Nathaniel P.; Letcher, Benjamin H.; Hocking, Daniel; Wofford, John E.B.

2015-01-01

Our results indicate that YOY abundance is a key driver of brook trout population dynamics that is mediated by seasonal weather patterns. A reliable assessment of climate change impacts on brook trout needs to account for how alternations in seasonal weather patterns impact YOY abundance and how such relationships may differ across the range of brook trout distribution.

The temperature-productivity squeeze: Constraints on brook trout growth along an Appalachian river continuum

USGS Publications Warehouse

Petty, J. Todd; Thorne, David; Huntsman, Brock M.; Mazik, Patricia M.

2014-01-01

We tested the hypothesis that brook trout growth rates are controlled by a complex interaction of food availability, water temperature, and competitor density. We quantified trout diet, growth, and consumption in small headwater tributaries characterized as cold with low food and high trout density, larger tributaries characterized as cold with moderate food and moderate trout density, and large main stems characterized as warm with high food and low trout density. Brook trout consumption was highest in the main stem where diets shifted from insects in headwaters to fishes and crayfish in larger streams. Despite high water temperatures, trout growth rates also were consistently highest in the main stem, likely due to competitively dominant trout monopolizing thermal refugia. Temporal changes in trout density had a direct negative effect on brook trout growth rates. Our results suggest that competition for food constrains brook trout growth in small streams, but access to thermal refugia in productive main stem habitats enables dominant trout to supplement growth at a watershed scale. Brook trout conservation in this region should seek to relieve the “temperature-productivity squeeze,” whereby brook trout productivity is constrained by access to habitats that provide both suitable water temperature and sufficient prey.

Brook Trout Back in Aaron Run

EPA Pesticide Factsheets

Following a series of acid mine drainage (AMD) projects funded largely by EPA’s Clean Water Act Section 319 non-point source program, the pH level in Aaron Run is meeting Maryland’s water quality standard – and the brook trout are back.

Air Combat Maneuvering Performance Measurement

DTIC Science & Technology

1979-09-01

John C. Reed Flying Training Division, Air rorce Human Resources Laboratory September 1979 NOTICE When-IU.S. Government drawings,, speci1fication,s, or...Technol’ogy Departmenit CommandeO,, ’Naval’ Trainin 7 Eqfuipieht Center A rdre_, Human Rsuce Ua~~tr <FGOVERNMENT RIGHTS IN dATfASThTEMENT’.- RoproddVctioh tff...91361 1 1231206.. . SCONTROLLING OFFICE NAME AND ADDRESS 12.82EI3ORLATE.) HQ Air Force Human Resources Laboratory (AFSC) V Stbpi 979J . /- Brooks Air

Harriet Brooks: Canada's First Woman Physicist

NASA Astrophysics Data System (ADS)

Rayner-Canham, Geoffrey

2004-03-01

During those early halcyon days of the study of radioactivity, one young Canadian woman, Harriet Brooks, joined Ernest Rutherford's group as his first research student. Later, she joined J.J. Thomson's group in Cambridge and, finally, Marie Curie's group in Paris. During her short research career, she made several important contributions to science. She investigated the nature of 'emanation' from radium; discovered that radioactive substances could undergo successive decay; and first reported the recoil of the radioactive atom. Much of this research was published under her name alone though Rutherford made extensive reference to her discoveries in his Bakerian lecture of 1904. Brooks life is of interest not only in what she accomplished, but also in the challenges she faced as a pioneering woman scientist in the early part of the twentieth century. In the presentation we will blend the account of her life and work with the societal context. This work was accomplished jointly with Marelene F. Rayner-Canham.

Fall and winter survival of brook trout and brown trout in a north-central Pennsylvania watershed

USGS Publications Warehouse

Sweka, John A.; Davis, Lori A.; Wagner, Tyler

2017-01-01

Stream-dwelling salmonids that spawn in the fall generally experience their lowest survival during the fall and winter due to behavioral changes associated with spawning and energetic deficiencies during this time of year. We used data from Brook Trout Salvelinus fontinalis and Brown Trout Salmo trutta implanted with radio transmitters in tributaries of the Hunts Run watershed of north-central Pennsylvania to estimate survival from the fall into the winter seasons (September 2012–February 2013). We examined the effects that individual-level covariates (trout species, size, and movement rates) and stream-level covariates (individual stream and cumulative drainage area of a stream) have on survival. Brook Trout experienced significantly lower survival than Brown Trout, especially in the early fall during their peak spawning period. Besides a significant species effect, none of the other covariates examined influenced survival for either species. A difference in life history between these species, with Brook Trout having a shorter life expectancy than Brown Trout, is likely the primary reason for the lower survival of Brook Trout. However, Brook Trout also spawn earlier in the fall than Brown Trout and low flows during Brook Trout spawning may have resulted in a greater risk of predation for Brook Trout compared with Brown Trout, thereby also contributing to the observed differences in survival between these species. Our estimates of survival can aid parameterization of future population models for Brook Trout and Brown Trout through the spawning season and into winter.

HPLC and ELISA analyses of larval bile acids from Pacific and western brook lampreys

USGS Publications Warehouse

Yun, S.-S.; Scott, A.P.; Bayer, J.M.; Seelye, J.G.; Close, D.A.; Li, W.

2003-01-01

Comparative studies were performed on two native lamprey species, Pacific lamprey (Lampetra tridentata) and western brook lamprey (Lampetra richardsoni) from the Pacific coast along with sea lamprey (Petromyzon marinus) from the Great Lakes, to investigate their bile acid production and release. HPLC and ELISA analyses of the gall bladders and liver extract revealed that the major bile acid compound from Pacific and western brook larval lampreys was petromyzonol sulfate (PZS), previously identified as a migratory pheromone in larval sea lamprey. An ELISA for PZS has been developed in a working range of 20pg-10ng per well. The tissue concentrations of PZS in gall bladder were 127.40, 145.86, and 276.96??g/g body mass in sea lamprey, Pacific lamprey, and western brook lamprey, respectively. Releasing rates for PZS in the three species were measured using ELISA to find that western brook and sea lamprey released PZS 20 times higher than Pacific lamprey did. Further studies are required to determine whether PZS is a chemical cue in Pacific and western brook lampreys. ?? 2003 Elsevier Inc. All rights reserved.

Quality of life after Brooke ileostomy and ileal pouch-anal anastomosis. Comparison of performance status.

PubMed Central

Pemberton, J H; Phillips, S F; Ready, R R; Zinsmeister, A R; Beahrs, O H

1989-01-01

Although the clinical results of Brooke ileostomy are good, patients are permanently incontinent of stool and gas. Alternative operations designed to restore enteric continence, such as ileal pouch-anal anastomosis, must not only be as safe and effective as Brooke ileostomy, but should provide an improved quality of life in order to establish long-term acceptability. Ileal pouch-anal anastomosis has been performed safely and good functional results have been reported. The quality of life after ileal pouch-anal anastomosis, however, has not been documented. Two hundred ninety-eight ileal pouch patients and 406 Brooke ileostomy patients who had the operations performed for chronic ulcerative colitis or familial adenomatous polyposis formed the basis of the study. After adjusting for age, diagnosis, and reoperation rate, logistic regression analysis of performance scores in seven different categories was used to discriminate between operations. Median follow-up was longer in Brooke ileostomy patients than in ileal pouch patients (104 months vs. 47 months, respectively), and Brooke ileostomy patients were slightly older (38 years vs. 32 years). A great majority of patients in each group were satisfied (93% Brooke ileostomy; 95% ileal pouch-anal anastomosis). Thirty-nine per cent of Brooke ileostomy patients, however, desired a change in the type of ileostomy they had. At 47 months, ileal pouch patients had a median of 5 stools per day and 1 at night, 77% did not experience any daytime incontinence, while 22% reported occasional spotting. In each performance category, the performance score discriminated between operations, with the probability of having had an ileal pouch-anal anastomosis operation increasing with improvement in performance scores (p less than 0.05). We concluded that after ileal pouch-anal anastomosis, patients experienced significant advantages in performing daily activities compared to patients with Brooke ileostomy and thus may experience a better

Brookings Papers on Education Policy, 1998.

ERIC Educational Resources Information Center

Ravitch, Diane, Ed.

In this inaugural issue of "Brookings Papers on Education Policy" a varied group of scholars considers different dimensions of student performance. Several contributors try to offer a clear picture of how American students are performing as compared with their international peers and with the past. The following are included: (1) "Introduction"…

Effect of brook trout removal from a spawning stream on an adfluvial population of Lahontan cutthroat trout

USGS Publications Warehouse

Scoppettone, G. Gary; Rissler, Peter H.; Shea, Sean P.; Somer, William

2012-01-01

Independence Lake (Nevada and Sierra counties, California) harbors the only extant native population of Lahontan cutthroat trout Oncorhynchus clarkii henshawi in the Truckee River system and one of two extant adfluvial populations in the Lahontan basin. The persistence of this population has been precarious for more than 50 years, with spawning runs consisting of only 30–150 fish. It is assumed that this population was much larger prior to the introduction of nonnative brook trout Salvelinus fontinalis. Brook trout overlap with cutthroat trout in upper Independence Creek, where the cutthroat trout spawn and their resulting progeny emigrate to Independence Lake. In 2005, we began removing brook trout from upper Independence Creek using electrofishers and monitored the cutthroat trout population. Stomach analysis of captured brook trout revealed cutthroat trout fry, and cutthroat trout fry survival increased significantly from 4% to 12% with brook trout removal. Prior to brook trout removal, the only Lahontan cutthroat trout progeny emigrating to Independence Lake were fry; with brook trout removal, juveniles were found entering the lake. In 2010, 237 potential spawners passed a prefabricated weir upstream of Independence Lake. Although the results of this study suggest that brook trout removal from upper Independence Creek has had a positive influence on the population dynamics of Independence Lake Lahontan cutthroat trout, additional years of removal are needed to assess the ultimate effect this action will have upon the cutthroat trout population.

Air Force Handbook. 109th Congress

DTIC Science & Technology

2009-01-01

FY06 Combat Survivor Evader Locator (CSEL) Acquisition Status Capabilities/Profile Functions /Performance Parameters 38 • Air Force’s primary source for...Broadcast Service (GBS) Capabilities/Profile Acquisition Status Functions /Performance Parameters • Purchase Requirements (Phase 2): • 3 primary ...Operations (AF CONOPS) that support the CSAF and joint vision of combat operations. • AF CONOPS describe key Air Force mission and/or functional areas

Brook trout passage performance through culverts

USGS Publications Warehouse

Goerig, Elsa; Castro-Santos, Theodore R.; Bergeron, Normand

2016-01-01

Culverts can restrict access to habitat for stream-dwelling fishes. We used passive integrated transponder telemetry to quantify passage performance of >1000 wild brook trout (Salvelinus fontinalis) attempting to pass 13 culverts in Quebec under a range of hydraulic and environmental conditions. Several variables influenced passage success, including complex interactions between physiology and behavior, hydraulics, and structural characteristics. The probability of successful passage was greater through corrugated metal culverts than through smooth ones, particularly among smaller fish. Trout were also more likely to pass at warmer temperatures, but this effect diminished above 15 °C. Passage was impeded at higher flows, through culverts with steep slopes, and those with deep downstream pools. This study provides insight on factors influencing brook trout capacity to pass culverts as well as a model to estimate passage success under various conditions, with an improved resolution and accuracy over existing approaches. It also presents methods that could be used to investigate passage success of other species, with implications for connectivity of the riverscape.

Superfund Record of Decision (EPA Region 5): Fields Brook sediment operable unit, Ashtabula, Ohio, September 1986. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1986-09-30

Fields Brook is located in the City of Ashtabula, Ohio and drains a 5.6-square mile watershed (defined as the 'site'). The 3.5 mile main channel of Fields Brook flows through an industrial area that is one of the largest and most diversified concentrations of chemical plants in Ohio. Industrial sources have contaminated the sediment in Fields Brook with a variety of organic and heavy metal pollutants, including TCE, PCE, chlorobenzene, vinyl chloride, arsenic, zinc, mercury and chromium. Base-neutral compounds including hexachloroethane, toluenediamine and toluene diisocyanate also were detected in Fields Brook sediments. Sediments taken from the Ashtabula River in themore » vicinity of Fields Brook are contaminated with PCBs. The U.S. EPA believes that the amount of contamination entering the brook at this time has been substantially reduced due to the recent development of pollution control laws and discharge-permitting requirements.« less

Air Force TV

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Competition and predation as mechanisms for displacement of greenback cutthroat trout by brook trout

Treesearch

C. C. McGrath; W. M. Lewis

2007-01-01

Cutthroat trout Oncorhynchus clarkii frequently are displaced by nonnative brook trout Salvelinus fontinalis, but the ecological mechanisms of displacement are not understood. Competition for food and predation between greenback cutthroat trout O. c. stomias and brook trout were investigated in montane streams of...

The Brooks Act, Is it Relevant Today?

DTIC Science & Technology

1994-06-01

Publishing Company, 1990. 7. Fla=., Kenneth. Creatina The ComDuter. Washington, D.C.: The Brookings Institution, 1988. 8. Gilchrist, Bruce, & Wessel...Milton R. Reaulation of the Computer Industry. Montvale: AFIPS Press, 1972. 9. Gore, Al. Creatina A Government That Works Better & Cost Less: Renort

Simulated effects of YY-male stocking and manual suppression for eradicating nonnative Brook Trout populations

USGS Publications Warehouse

Schill, Daniel J.; Meyer, Kevin A.; Hansen, Michael J.

2017-01-01

Eradication of nonnative Brook Trout Salvelinus fontinalis populations is difficult to achieve with standard techniques, such as electrofishing removal or piscicides; new approaches are needed. A novel concept is to stock “supermale” hatchery fish with wild conspecifics. Supermales (MYY) have two Y-chromosomes, resulting in offspring that are all males; over time, successful supermale reproduction could eradicate the wild population. We constructed an age-structured stochastic model to investigate the effects of manually suppressing wild fish and stocking MYY fingerlings on the long-term viability of hypothetical nonnative Brook Trout populations. In streams, an annual stocking rate of supermales equivalent to 50% of wild age-0 Brook Trout density combined with an annual selective suppression rate equivalent to 50% of wild Brook Trout density resulted in a time to extirpation of only 2–4 years if supermale fitness was equivalent to wild male fitness. However, time to extirpation in streams was 5–15 years if supermale fitness was 80% lower than wild male fitness. In alpine lakes, higher supermale stocking rates and nonselective gillnetting were required to eradicate Brook Trout populations. If supermales were assumed to be as fit as wild males, however, any supermale stocking rate greater than 49% in alpine lakes or 60% in streams achieved eradication in 10 years or less, regardless of the suppression rate. Because manual suppression and the stocking of MYY fingerlings can readily be conducted at the levels assumed in our simulations, use of such an integrated pest management (IPM) approach could extirpate undesirable Brook Trout populations within reasonably short periods of time. Given the recent successful development of an MYY Brook Trout broodstock capable of producing large numbers of MYY fingerlings and given the positive results of the present simulations for both streams and alpine lakes, field testing of MYY stocking is warranted within an

Nearshore habitat and fish community associations of coaster brook trout in Isle Royale, Lake Superior

USGS Publications Warehouse

Gorman, O.T.; Moore, S.A.; Carlson, A.J.; Quinlan, H.R.

2008-01-01

We characterized the nearshore habitat and fish community composition of approximately 300 km of shoreline within and adjacent to the major embayments of Isle Royale, Lake Superior. Sampling yielded 17 species, of which 12 were widespread and represented a common element of the Lake Superior fish community, including cisco Coregonus artedi, lake whitefish C. clupeaformis, round whitefish Prosopium cylindraceum, lake trout Salvelinus namaycush, rainbow smelt Osmerus mordax, lake chub Couesius plumbeus, longnose sucker Catostomus catostomus, white sucker C. commersonii, trout-perch Percopsis omiscomaycus, ninespine stickleback Pungitius pungitius, burbot Lota lota, and slimy sculpin Cottus cognatus. The presence of brook trout S. fontinalis in an embayment was associated with the common species of the Isle Royale nearshore fish community, particularly cisco, longnose sucker, and round whitefish. However, brook trout were present in only five embayments and were common only in Tobin Harbor. Most Isle Royale embayments had broadly overlapping ranges of nearshore habitats. Within embayments, fish were distributed along a habitat gradient from less-protected rocky habitat near the mouth to highly protected habitat with mixed and finer substrates at the head. Embayments with brook trout had greater mean protection from the open lake, greater variation in depth, greater mean cover, and higher mean frequencies of large substrates (cobble, boulder, and bedrock). Within those embayments, brook trout were associated with habitat patches with higher mean frequencies of small substrates (particularly sand and coarse gravel). Within Tobin Harbor, brook trout were associated with midembayment habitat and species assemblages, especially those locations with a mixture of sand, gravel, and cobble substrates, an absence of bedrock, and the presence of round whitefish, white sucker, and trout-perch. Comparison of embayments with the model, Tobin Harbor, showed that six embayments

Predicting Brook Trout occurrence in stream reaches throughout their native range in the eastern United States

USGS Publications Warehouse

DeWeber, Jefferson Tyrell; Wagner, Tyler

2015-01-01

The Brook Trout Salvelinus fontinalis is an important species of conservation concern in the eastern USA. We developed a model to predict Brook Trout population status within individual stream reaches throughout the species’ native range in the eastern USA. We utilized hierarchical logistic regression with Bayesian estimation to predict Brook Trout occurrence probability, and we allowed slopes and intercepts to vary among ecological drainage units (EDUs). Model performance was similar for 7,327 training samples and 1,832 validation samples based on the area under the receiver operating curve (∼0.78) and Cohen's kappa statistic (0.44). Predicted water temperature had a strong negative effect on Brook Trout occurrence probability at the stream reach scale and was also negatively associated with the EDU average probability of Brook Trout occurrence (i.e., EDU-specific intercepts). The effect of soil permeability was positive but decreased as EDU mean soil permeability increased. Brook Trout were less likely to occur in stream reaches surrounded by agricultural or developed land cover, and an interaction suggested that agricultural land cover also resulted in an increased sensitivity to water temperature. Our model provides a further understanding of how Brook Trout are shaped by habitat characteristics in the region and yields maps of stream-reach-scale predictions, which together can be used to support ongoing conservation and management efforts. These decision support tools can be used to identify the extent of potentially suitable habitat, estimate historic habitat losses, and prioritize conservation efforts by selecting suitable stream reaches for a given action. Future work could extend the model to account for additional landscape or habitat characteristics, include biotic interactions, or estimate potential Brook Trout responses to climate and land use changes.

International trends in clinical characteristics and oral anticoagulation treatment for patients with atrial fibrillation: Results from the GARFIELD-AF, ORBIT-AF I, and ORBIT-AF II registries.

PubMed

Steinberg, Benjamin A; Gao, Haiyan; Shrader, Peter; Pieper, Karen; Thomas, Laine; Camm, A John; Ezekowitz, Michael D; Fonarow, Gregg C; Gersh, Bernard J; Goldhaber, Samuel; Haas, Sylvia; Hacke, Werner; Kowey, Peter R; Ansell, Jack; Mahaffey, Kenneth W; Naccarelli, Gerald; Reiffel, James A; Turpie, Alexander; Verheugt, Freek; Piccini, Jonathan P; Kakkar, Ajay; Peterson, Eric D; Fox, Keith A A

2017-12-01

Atrial fibrillation (AF) is the most common cardiac arrhythmia in the world. We aimed to provide comprehensive data on international patterns of AF stroke prevention treatment. Demographics, comorbidities, and stroke risk of the patients in the GARFIELD-AF (n=51,270), ORBIT-AF I (n=10,132), and ORBIT-AF II (n=11,602) registries were compared (overall N=73,004 from 35 countries). Stroke prevention therapies were assessed among patients with new-onset AF (≤6 weeks). Patients from GARFIELD-AF were less likely to be white (63% vs 89% for ORBIT-AF I and 86% for ORBIT-AF II) or have coronary artery disease (19% vs 36% and 27%), but had similar stroke risk (85% CHA 2 DS 2 -VASc ≥2 vs 91% and 85%) and lower bleeding risk (11% with HAS-BLED ≥3 vs 24% and 15%). Oral anticoagulant use was 46% and 57% for patients with a CHA 2 DS 2 -VASc=0 and 69% and 87% for CHA 2 DS 2 -VASc ≥2 in GARFIELD-AF and ORBIT-AF II, respectively, but with substantial geographic heterogeneity in use of oral anticoagulant (range: 31%-93% [GARFIELD-AF] and 66%-100% [ORBIT-AF II]). Among patients with new-onset AF, non-vitamin K antagonist oral anticoagulant use increased over time to 43% in 2016 for GARFIELD-AF and 71% for ORBIT-AF II, whereas use of antiplatelet monotherapy decreased from 36% to 17% (GARFIELD-AF) and 18% to 8% (ORBIT-AF I and II). Among new-onset AF patients, non-vitamin K antagonist oral anticoagulant use has increased and antiplatelet monotherapy has decreased. However, anticoagulation is used frequently in low-risk patients and inconsistently in those at high risk of stroke. Significant geographic variability in anticoagulation persists and represents an opportunity for improvement. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

The use of hoop nets seeded with mature brook trout to capture conspecifics

Treesearch

James A. Lamansky; Ernest R. Keeley; Michael K. Young; Kevin A. Meyer

2009-01-01

The brook trout Salvelinus fontinalis, a native of eastern North America, is considered an invasive species in the western United States because it has been implicated in the decline of many native trout species there. Current methods for controlling brook trout are usually time-consuming and expensive and are sometimes harmful to nontarget species....

Brook trout movement during and after recolonization of a naturally defaunated stream reach

Treesearch

Craig N. Roghair; C. Andrew Dolloff

2005-01-01

In june 1995 a debris flow associated with a massive streamwide flood completely eliminated brook trout Salvelinus fontinalis from the lower 1.9 km of the Staunton River in Shenandoah National Park, Virginia. Biannual diver counts revealed that brook trout moved several hundred meters into the debris-flow-affected area each year, resulting in...

Introduction to the Stony Brook Library: A Self-Paced Workbook for INT 150.

ERIC Educational Resources Information Center

Baum, Nathan; And Others

Designed to acquaint Stony Brook students with the facilities and resources of their library, this workbook in library skills is used in conjunction with courses offered at the State University of New York at Stony Brook. It is organized into chapters dealing with types of materials rather than by area of the library. Each chapter has an…

Biological consequences of the coaster brook trout restoration stocking program in Lake Superior tributaries with Pictured Rocks National Lakeshore

USGS Publications Warehouse

Leonard, Jill B.K.; Stott, Wendylee; Loope, Delora M.; Kusnierz, Paul C.; Sreenivasan, Ashwin

2013-01-01

The coaster Brook Trout Salvelinus fontinalis is a Lake Superior ecotype representing intraspecific variation that has been impacted by habitat loss and overfishing. Hatchery strains of Brook Trout derived from populations in Lake Superior were stocked into streams within Pictured Rocks National Lakeshore, Michigan, as part of an effort to rehabilitate adfluvial coaster Brook Trout. Wild and hatchery Brook Trout from three streams (Mosquito River, Hurricane River, and Sevenmile Creek) were examined for movement behavior, size, physiology, and reproductive success. Behavior and size of the stocked fish were similar to those of wild fish, and less than 15% of the stocked, tagged Brook Trout emigrated from the river into which they were stocked. There was little evidence of successful reproduction by stocked Brook Trout. Similar to the results of other studies, our findings suggest that the stocking of nonlocal Brook Trout strains where a local population already exists results in limited natural reproduction and should be avoided, particularly if the mechanisms governing the ecotype of interest are poorly understood.

Osan AB, Korea. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1982-06-14

USAFETAC SURFACE WINDS2 AIR WATHER SERVICE/MAC PERCENTAGE FREQUENCY OF WIND DIRECTION AND SPEED (FROM HOURLY OBSERVATIONS) 1471220 OSAN AS KO 73-S1 FED...BRANCHusAF’TAC SURFACE WINDS AIR WATHER SERVICE/MAC PERCENTAGE FREQUENCY OF WIND DIRECTION AND SPEED (FROM HOURLY OBSERVATIONS) 47122’ OSAN AS KO 73-81 NOV _RLL

Around the Air Force: April 26 > U.S. Air Force > Article Display

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William Keith Brooks and the naturalist's defense of Darwinism in the late-nineteenth century.

PubMed

Nash, Richard

2015-06-01

William Keith Brooks was an American zoologist at Johns Hopkins University from 1876 until his death in 1908. Over the course of his career, Brooks staunchly defended Darwinism, arguing for the centrality of natural selection in evolutionary theory at a time when alternative theories, such as neo-Lamarckism, grew prominent in American biology. In his book The Law of Heredity (1883), Brooks addressed problems raised by Darwin's theory of pangenesis. In modifying and developing Darwin's pangenesis, Brooks proposed a new theory of heredity that sought to avoid the pitfalls of Darwin's hypothesis. In so doing he strengthened Darwin's theory of natural selection by undermining arguments for the inheritance of acquired characteristics. In later attacks on neo-Lamarckism, Brooks consistently defended Darwin's theory of natural selection on logical grounds, continued to challenge the idea of the inheritance of acquired characteristics, and argued that natural selection best explained a wide range of adaptations. Finally, he critiqued Galton's statistical view of heredity and argued that Galton had resurrected an outmoded typological concept of species, one which Darwin and other naturalists had shown to be incorrect. Brooks's ideas resemble the "biological species concept" of the twentieth century, as developed by evolutionary biologist Ernst Mayr and others. The late-nineteenth century was not a period of total "eclipse" of Darwinism, as biologists and historians have hitherto seen it. Although the "Modern Synthesis" refers to the reconciliation of post-Mendelian genetics with evolution by natural selection, we might adjust our understanding of how the synthesis developed by seeing it as the culmination of a longer discussion that extends back to the late-nineteenth century.

Shale Gas Development and Brook Trout: Scaling Best Management Practices to Anticipate Cumulative Effects

USGS Publications Warehouse

Smith, David; Snyder, Craig D.; Hitt, Nathaniel P.; Young, John A.; Faulkner, Stephen P.

2012-01-01

Shale gas development may involve trade-offs between energy development and benefits provided by natural ecosystems. However, current best management practices (BMPs) focus on mitigating localized ecological degradation. We review evidence for cumulative effects of natural gas development on brook trout (Salvelinus fontinalis) and conclude that BMPs should account for potential watershed-scale effects in addition to localized influences. The challenge is to develop BMPs in the face of uncertainty in the predicted response of brook trout to landscape-scale disturbance caused by gas extraction. We propose a decision-analysis approach to formulating BMPs in the specific case of relatively undisturbed watersheds where there is consensus to maintain brook trout populations during gas development. The decision analysis was informed by existing empirical models that describe brook trout occupancy responses to landscape disturbance and set bounds on the uncertainty in the predicted responses to shale gas development. The decision analysis showed that a high efficiency of gas development (e.g., 1 well pad per square mile and 7 acres per pad) was critical to achieving a win-win solution characterized by maintaining brook trout and maximizing extraction of available gas. This finding was invariant to uncertainty in predicted response of brook trout to watershed-level disturbance. However, as the efficiency of gas development decreased, the optimal BMP depended on the predicted response, and there was considerable potential value in discriminating among predictive models through adaptive management or research. The proposed decision-analysis framework provides an opportunity to anticipate the cumulative effects of shale gas development, account for uncertainty, and inform management decisions at the appropriate spatial scales.

Streambed-material characteristics and surface-water quality, Green Pond Brook and tributaries, Picatinny Arsenal, New Jersey, 1983-90

USGS Publications Warehouse

Storck, D.A.; Lacombe, Pierre

1996-01-01

This report presents the results of a study designed to determine whether Green Pond Brook and its tributaries contain contaminated streambed sediments and to characterize the quaity of water in the brook. Results of previous investigations at Picatinny Arsenal, Morris County, New Jersey, indicate that significant contamination of ground water, surface water, and soil is present at the arsenal. Forty-five streambed-material samples were collected for analysis to determine whether contaminants have migrated to the brook from the surrounding area. Samples were analyzed for trace elements, base/neutral- and acid-etractable compounds, insecticides, and other constituents. Results of an electromagnetic-conductivity and natural-gamma-ray survey were used to describe the distribution of particle sizes in streambed and substreambed sediments. Historical results of analyses of streambed-material and surface-water samples also are presented. Samples of streambed material from three areas in Green Pond Brook and its tributaries contained organic and (or) inorganic constituents in concentrations greater than those typically found at the arsenal. These areas are Green Pond Brook, from the area near the outflow of Picatinny Lake downstream to Farley Avenue; Bear Swamp Brook, from the area near building 241 downstream to the confluence with Green Pond Brook; and Green Pond Brook, from the open burning area downstream to the dam near building 1178. Contaminants identified include trace elements, polynuclear aromatic hydrocarbons, polychlorinated biphenyls, and organochlorine insecticides. Surface water in Green Pond Brook contained several volatile organic compounds, including trichloroethylene, tetrachloroethylene, and 1,2-dichloroethylene, at maximum concen- trations of 3.8, 4.6, and 11 micrograms per liter, respectively. Volatilization is expected to remove volatile organic compounds in the steep, fast- flowing reaches of the brook. No organic or inorganic constituents were

Sulfonamide toxicity in brook trout

USGS Publications Warehouse

Wood, E.M.; Yasutake, W.T.; Snieszko, S.F.

1954-01-01

Sterility was observed in female brook trout that were treated with sulfamerazine at frequent intervals for 2 years to control endemic furunculosis. Feeding sulfamerazine for a period of 8 months caused massive kidney damage similar to that observed in humans who develop allergies to “sulfa” drugs. Kidney damage of the type observed would probably cause renal insufficiency which would handicap any physiological function including reproduction. Feeding sulfonamides for periods up to 13 weeks did not produce kidney damage.

Air Force Officer Specialty Structure. Reviewing the Fundamentals

DTIC Science & Technology

2009-01-01

Corporation, is the U.S. Air Force’s federally funded research and development center for studies and analyses. PAF pro - vides the Air Force with...Shirlene LeBleu for sharing their database and insights about job con - tent and specialty analyses. At the Air Force Manpower Agency, we thank Col...processes. Also, we thank Maj Ernest Wearren (AF/ A1MZ) and Gary Stockinger (AF/A1MX) for sharing their knowledge of the Manpower Pro - gramming Execution

Does the introduced brook trout ( Salvelinus fontinalis) affect growth of the native brown trout ( Salmo trutta)?

NASA Astrophysics Data System (ADS)

Korsu, Kai; Huusko, Ari; Muotka, Timo

2009-03-01

Non-native brook trout have become widely established in North European streams. We combined evidence from an artificial-stream experiment and drainage-scale field surveys to examine whether brook trout suppressed the growth of the native brown trout (age 0 to age 2). Our experimental results demonstrated that brown trout were unaffected by the presence of brook trout but that brook trout showed reduced growth in the presence of brown trout. However, the growth reduction only appeared in the experimental setting, indicating that the reduced spatial constraint of the experimental system may have forced the fish to unnaturally intense interactions. Indeed, in the field, no effect of either species on the growth of the putative competitor was detected. These results caution against uncritical acceptance of findings from small-scale experiments because they rarely scale up to more complex field situations. This and earlier work suggest that the establishment of brook trout in North European streams has taken place mainly because of the availability of unoccupied (or underutilized) niche space, rather than as a result of species trait combinations or interspecific competition per se.

Dietary calcein marking of brook trout, Atlantic salmon, yellow perch, and coho salmon scales

USGS Publications Warehouse

Honeyfield, D.C.; Ostrowski, C.S.; Fletcher, J.W.; Mohler, J.W.

2006-01-01

Brook trout Salvelinus fontinalis, Atlantic salmon Salmo salar, coho salmon Oncorhynchus kisutch, and yellow perch Perca flavescens fed calcein for 5 d showed characteristic calcein scale marks 7-10 d postmarking. In fish fed 0.75 or 1.25 g of calcein per kilogram of feed, the percentage of fish that exhibited a calcein mark was 100% in brook trout, 93-98% in Atlantic salmon, 60% in yellow perch, and 0% in coho salmon. However, when coho salmon were fed 5.25 g calcein/kg feed, 100% marking was observed 7-10 d postmarking. Brook trout were successfully marked twice with distinct bands when fed calcein 5 months apart. Brook trout scale pixel luminosity increased as dietary calcein increased in experiment 2. For the second calcein mark, scale pixel luminosity from brook trout fed 1.25 g calcein/kg feed was numerically higher (P < 0.08) than scales from fish fed 0.75 g calcein/kg feed. Mean pixel luminosity of calcein-marked Atlantic salmon scales was 57.7 for fish fed 0.75 g calcein/kg feed and 55.2 for fish fed 1.25 g calcein/kg feed. Although feed acceptance presented a problem in yellow perch, these experiments provide evidence that dietary calcein is a viable tool for marking fish for stock identification. ?? Copyright by the American Fisheries Society 2006.

A geologic framework for mineralization in the western Brooks Range

USGS Publications Warehouse

Young, Lorne E.

2004-01-01

The Brooks Range is a 950-km-long north-vergent fold and thrust belt, which was formed during Mesozoic convergence of the continental Arctic Alaska terrane and the oceanic Angayucham terrane and was further shortened and uplifted in Tertiary time. The Arctic Alaska terrane consists of parautochthonous rocks and the Endicott Mountains and De Long Mountains subterranes. The Endicott Mountains allochthon of the western Brooks Range is the setting for many sulfide and barite occurrences, such as the supergiant Red Dog zinc-lead mine. Mineralization is sediment hosted and most commonly is present in black shale and carbonate turbidites of the Mississippian Kuna Formation. The reconstructed Kuna basin is a 200 by +600 km feature that represents the culmination of a remarkable chain of events that includes three fluvial-deltaic and two or more orogenic cycles, Middle Devonian to Mississippian episodes of extension and igneous activity, and the emergence of a seaward Lower Proterozoic landmass that may have constituted a barrier to marine circulation. Mississippian extension and related horst-and-graben architecture in the western Brooks Range is manifested in part by strong facies variability between coeval units of allochthons and structural plates. Shallow marine to possibly nonmarine arkose, platform to shelf carbonate, slope-to-basin shale, chert and carbonate turbidites, and submarine volcanic rocks are all represented in Mississippian time. The structural setting of Mississippian sedimentation, volcanism, and mineralization in the Kuna basin may be comparable to documented Devono-Mississippian extensional sags or half-grabens in the subsurface north of the Brooks Range. Climate, terrestrial ecosystems, multiple fluvial-deltaic aquifers, and structural architecture affected the liberation, movement, and redeposition of metals in ways that are incompletely understood.

Delineation of Areas Contributing Water to the Dry Brook Public-Supply Well, South Hadley, Massachusetts

USGS Publications Warehouse

Garabedian, Stephen P.; Stone, Janet Radway

2004-01-01

Areas contributing water to the Dry Brook public-supply well in South Hadley, Massachusetts, were delineated with a numerical ground-water-flow model that is based on geologic and hydrologic information for the confined sand and gravel aquifer pumped by the supply well. The study area is along the Connecticut River in central Massachusetts, about 12 miles north of Springfield, Massachusetts. Geologic units in the study area consist of Mesozoic-aged sedimentary and igneous bedrock, late-Pleistocene glaciolacustrine sediments, and recent alluvial deposits of the Connecticut River flood plain. Dry Brook Hill, immediately south of the supply well, is a large subaqueous lacustrine fan and delta formed during the last glacial retreat by sediment deposition into glacial Lake Hitchcock from a meltwater tunnel that was likely near where the Connecticut River cuts through the Holyoke Range. The sediments that compose the aquifer grade from very coarse sand and gravel along the northern flank of the hill, to medium sands in the body of the hill, and to finer-grained sediments along the southern flank of the hill. The interbedded and overlapping fine-grained lacustrine sediments associated with Dry Brook Hill include varved silt and clay deposits. These fine-grained sediments form a confining bed above the coarse-grained aquifer at the supply well and partially extend under the Connecticut River adjacent to the supply well. Ground-water flow in the aquifer supplying water to Dry Brook well was simulated with the U.S. Geological Survey ground-water-flow modeling code MODFLOW. The Dry Brook aquifer model was calibrated to drawdown data collected from 8 observation wells during an aquifer test conducted by pumping the supply well for 10 days at a rate of 122.2 cubic feet per minute (ft3/min; 914 gallons per minute) and to water levels collected from observation wells across the study area. Generally, the largest hydraulic conductivity values used in the model were in the sand and

Air Force officials name SARC of the year > U.S. Air Force > Article

Science.gov Websites

The Book Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games

Aspergillus fumigatus (Af) Hydroxamate Siderophores Protect Formation of Af Biofilms from the Pseudomonas aeruginosa (Pa) Product Pyoverdine

PubMed Central

Sass, Gabriele; Stevens, David A

2017-01-01

Abstract Background Pa and Af are pathogens frequently found together in airways of immunocompromised patients and patients with cystic fibrosis (CF). Hence, interactions of Pa and Af require understanding. Both Pa and Af are crucially dependent on the availability of iron, and therefore are competitors in their microenvironment. We have shown, using deletion mutants of Pa, that the Pa siderophore pyoverdine, the dominant Pa inhibitor of Af, interferes with Af biofilms by iron chelation, and denial of iron to the fungus. Methods Protective compounds in Af supernatants were evaluated using assays for the quantification of Af biofilm metabolism by XTT measurement, spectrometric pyoverdine measurement, as well as Chrome Azorole S (CAS) assay for the determination of siderophore production. Results Here we provide evidence that whereas iron usage by Af promotes pyoverdine production by Pa, Af has developed a defense mechanism against anti-fungal pyoverdine effects. The ability of Af to produce hydroxamate siderophores, and shed these into the surrounding medium, where they sequester and transport iron, is a key factor for Af self-defense against Pa. Under low iron conditions, such as in the presence of high amounts of the Pa siderophore pyoverdine, siderophore-bound iron is then fed to Af, protecting the fungus from iron starvation. Af with a deletion mutation in sidA, a gene essential for the production of hydroxamate siderophores, was significantly more sensitive to Pa supernatants, as well as pure pyoverdine, than wild-type Af. Af supernatants, produced in the presence of celastrol, an inhibitor of SidA-generated biosynthesis of siderophores, or produced by the sidA mutant, were not able to protect Af from iron starvation. Conclusion Interference with the iron-dependent Af self-defense mechanism might represent a new approach for therapy against aspergillosis. Disclosures All authors: No reported disclosures.

Air Force Senior Leaders

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Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Air Force Radio News

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Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Design for Resilience in Brattleboro's Lower Whetstone Brook Corridor

EPA Pesticide Factsheets

This report details design solutions that identify options for creating resilient redevelopment & recreational opportunities within flood prone areas of the town while protecting water quality & connecting people with the Whetstone Brook.

Global climate change and fragmentation of native brook trout distribution in the southern Appalachian Mountains

Treesearch

Patricia A. Flebbe

1997-01-01

Current distributions of native brook trout (Salvelinus fontinalis) in the Southern Appalachians are restricted to upper elevations by multiple factors, including habitat requirements, introduced rainbow (Oncorhynchus mykiss) and brown (Salmo trutta) trout, and other human activities. Present-day distribution of brook trout habitat is already fragmented. Increased...

Brookings-Wharton Papers on Urban Affairs: 2006

ERIC Educational Resources Information Center

Burtless, Gary, Ed.; Pack, Janet Rothenberg, Ed.

2006-01-01

Designed to reach a wide audience of scholars and policymakers, the "Brookings-Wharton Papers on Urban Affairs" is an annual series that serves as a forum for cutting-edge, accessible research on urban policy. The editors seek to integrate broader research into the policy discussion by bringing urban studies scholars together with economists and…

Amoxicillin pulsatile - MiddleBrook: APC 111, APC-111, PULSYS-enhanced amoxicillin.

PubMed

2007-01-01

MiddleBrook Pharmaceuticals (formerly Advancis Pharmaceutical) is developing an improved version of amoxicillin using its pulsatile oral drug delivery technology, called PULSYS. Amoxicillin PULSYS is intended to provide a lower treatment dose, once-daily alternative to currently approved amoxicillin and penicillin regimens for the treatment of adolescents/adults with pharyngitis and/or tonsillitis. If amoxicillin PULSYS is approved, it will be the first and only once-daily amoxicillin therapy approved for use in the US. Regulatory submissions for the treatment of pharyngitis/tonsillitis have been made in the US. Amoxicillin PULSYS is in clinical development for the treatment of pharyngitis and/or tonsillitis due to group A streptococcal infections in adolescents/adults as a tablet formulation. MiddleBrook was conducting clinical development of a sprinkle formulation for children. However, this has been put on hold for financial reasons. MiddleBrook is seeking regulatory approval for this product as a 505(b)(2) product, which is one that is not considered to be a completely new product, but is also not a generic product. It is a product with some differences from a previously approved product and clinical data to support such differences are required; however, the basic safety and efficacy studies may have been conducted by other organisations. In June 2007, Advancis Pharmaceutical was renamed as MiddleBrook Pharmaceuticals, Inc. MiddleBrook and Par Pharmaceuticals entered a co-promotion agreement for this product in June 2004. Par was to fund future development in exchange for co-exclusive marketing rights and exclusive rights to sell amoxicillin PULSYS. MiddleBrook retained responsibility for the manufacturing programme and also retained all patents and brand names and was responsible for their enforcement. However, this collaboration was subsequently terminated in August 2005 by Par Pharmaceutical. MiddleBrook received the US $4.75 million R&D reimbursement

Health Information in Somali (Af-Soomaali )

MedlinePlus

... Af-Soomaali (Somali) Bilingual PDF Health Information Translations Pendulum Exercises for Shoulder - Af-Soomaali (Somali) Bilingual PDF ... Af-Soomaali (Somali) Bilingual PDF Health Information Translations Pendulum Exercises for Shoulder - Af-Soomaali (Somali) Bilingual PDF ...

Secretary of the Air Force

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Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

The Air University 404 Page

Science.gov Websites

(National Guard) AFITC Conference Air Force Information Technology and Cyberpower Conference graphic The Air Air University Banner AU Home AETC AU FAQs AU Index AU Schools AU Site Contacts USAF AF Recruiting AFRC Recruiting AU Links About Air University AU Academic Office AU Accreditation AU Board of Visitors

Plum Brook Reactor Facility Control Room during Facility Startup

NASA Image and Video Library

1961-02-21

Operators test the National Aeronautics and Space Administration’s (NASA) Plum Brook Reactor Facility systems in the months leading up to its actual operation. The “Reactor On” signs are illuminated but the reactor core was not yet ready for chain reactions. Just a couple weeks after this photograph, Plum Brook Station held a media open house to unveil the 60-megawatt test reactor near Sandusky, Ohio. More than 60 members of the print media and radio and television news services met at the site to talk with community leaders and representatives from NASA and Atomic Energy Commission. The Plum Brook reactor went critical for the first time on the evening of June 14, 1961. It was not until April 1963 that the reactor reached its full potential of 60 megawatts. The reactor control room, located on the second floor of the facility, was run by licensed operators. The operators manually operated the shim rods which adjusted the chain reaction in the reactor core. The regulating rods could partially or completely shut down the reactor. The control room also housed remote area monitoring panels and other monitoring equipment that allowed operators to monitor radiation sensors located throughout the facility and to scram the reactor instantly if necessary. The color of the indicator lights corresponded with the elevation of the detectors in the various buildings. The reactor could also shut itself down automatically if the monitors detected any sudden irregularities.

Influence of landscape-scale factors in limiting brook trout populations in Pennsylvania streams

USGS Publications Warehouse

Kocovsky, P.M.; Carline, R.F.

2006-01-01

Landscapes influence the capacity of streams to produce trout through their effect on water chemistry and other factors at the reach scale. Trout abundance also fluctuates over time; thus, to thoroughly understand how spatial factors at landscape scales affect trout populations, one must assess the changes in populations over time to provide a context for interpreting the importance of spatial factors. We used data from the Pennsylvania Fish and Boat Commission's fisheries management database to investigate spatial factors that affect the capacity of streams to support brook trout Salvelinus fontinalis and to provide models useful for their management. We assessed the relative importance of spatial and temporal variation by calculating variance components and comparing relative standard errors for spatial and temporal variation. We used binary logistic regression to predict the presence of harvestable-length brook trout and multiple linear regression to assess the mechanistic links between landscapes and trout populations and to predict population density. The variance in trout density among streams was equal to or greater than the temporal variation for several streams, indicating that differences among sites affect population density. Logistic regression models correctly predicted the absence of harvestable-length brook trout in 60% of validation samples. The r 2-value for the linear regression model predicting density was 0.3, indicating low predictive ability. Both logistic and linear regression models supported buffering capacity against acid episodes as an important mechanistic link between landscapes and trout populations. Although our models fail to predict trout densities precisely, their success at elucidating the mechanistic links between landscapes and trout populations, in concert with the importance of spatial variation, increases our understanding of factors affecting brook trout abundance and will help managers and private groups to protect and

Can brook trout survive climate change in large rivers? If it rains.

PubMed

Merriam, Eric R; Fernandez, Rodrigo; Petty, J Todd; Zegre, Nicolas

2017-12-31

We provide an assessment of thermal characteristics and climate change vulnerability for brook trout (Salvelinus fontinalis) habitats in the upper Shavers Fork sub-watershed, West Virginia. Spatial and temporal (2001-2015) variability in observed summer (6/1-8/31) stream temperatures was quantified in 23 (9 tributary, 14 main-stem) reaches. We developed a mixed effects model to predict site-specific mean daily stream temperature from air temperature and discharge and coupled this model with a hydrologic model to predict future (2016-2100) changes in stream temperature under low (RCP 4.5) and high (RCP 8.5) emissions scenarios. Observed mean daily stream temperature exceeded the 21°C brook trout physiological threshold in all but one main-stem site, and 3 sites exceeded proposed thermal limits for either 63- and 7-day mean stream temperature. We modeled mean daily stream temperature with a high degree of certainty (R 2 =0.93; RMSE=0.76°C). Predicted increases in mean daily stream temperature in main-stem and tributary reaches ranged from 0.2°C (RCP 4.5) to 1.2°C (RCP 8.5). Between 2091 and 2100, the average number of days with mean daily stream temperature>21°C increased within main-stem sites under the RCP 4.5 (0-1.2days) and 8.5 (0-13) scenarios; however, no site is expected to exceed 63- or 7-day thermal limits. During the warmest 10years, ≥5 main-stem sites exceeded the 63- or 7-day thermal tolerance limits under both climate emissions scenarios. Years with the greatest increases in stream temperature were characterized by low mean daily discharge. Main-stem reaches below major tributaries never exceed thermal limits, despite neighboring reaches having among the highest observed and predicted stream temperatures. Persistence of thermal refugia within upper Shavers Fork would enable persistence of metapopulation structure and life history processes. However, this will only be possible if projected increases in discharge are realized and offset expected

Aft Skirt Move from Hangar AF to BFF

NASA Image and Video Library

2016-09-08

The left hand aft skirt for NASA’s Space Launch System (SLS) rocket arrives at the Booster Fabrication Facility at the agency’s Kennedy Space Center in Florida, from the Hangar AF facility at Cape Canaveral Air Force Station. The space shuttle-era aft skirt, was inspected, resurfaced, primed and painted for use on the left hand booster of the SLS rocket for Exploration Mission 1 (EM-1). NASA is preparing for EM-1, deep-space missions, and the journey to Mars.

A Bibliography of Selected Publications: Project Air Force, 5th Edition

DTIC Science & Technology

1989-05-01

Dyna - R-3028-AF. A Dynamic Retention Model for Air Force Officers: METRIC’s DL and and Pipeilne Variability. M. J. Carrillo. Theory and Estimates. G...Theorem and Dyna - and Support. METRIC’s Demand and Pipeline Variability. R-3255-AF. Aircraft Airframe Cost Estimating Relationships: N-2283/1-AF...U). 1970-1985. N-2409-AF. Tanker Splitting Across the SlOP Bomber Force R-3389-AF. Dyna -METRIC Version 4: Modeling Worldwide (U). Logistics Support of

Topological ferrimagnetic behaviours of coordination polymers containing manganese(II) chains with mixed azide and carboxylate bridges and alternating F/AF/AF'/AF'/AF interactions.

PubMed

Wang, Yan-Qin; Liu, Hou-Ting; Qi, Yan; Gao, En-Qing

2014-08-21

Two Mn(ii) complexes with azide and a new zwitterionic tetracarboxylate ligand 1,2,4,5-tetrakis(4-carboxylatopyridinium-1-methylene)benzene (L(1)), {[Mn5(L(1))2(N3)8(OH)2]·12H2O}n () and {[Mn5(L(1))2(N3)8(H2O)2](ClO4)2·6H2O}n (), have been synthesized and characterized crystallographically and magnetically. and contain similar alternating chains constructed by azide and carboxylate bridges. The independent sets of bridges alternate in an ABCCB sequence between adjacent Mn(ii) ions: (EO-N3)2 double bridges (EO = end-on) (denoted as A), [(EO-N3)(OCO)2] triple bridges (denoted as B) and [(EO-N3)(OCO)] double bridges (denoted as C). The alternating chains are interlinked into 2D coordination networks by the tetrapyridinium spacers. Magnetic studies demonstrate that the magnetic coupling through the double EO azide bridges is ferromagnetic and that through mixed azide/carboxylate bridges is antiferromagnetic. The unprecedented F/AF/AF'/AF'/AF coupling sequence along the chain dictates an uncompensated ground spin state (S = 5/2 per Mn5 unit) and leads to one-dimensional topological ferrimagnetism, which features a minimum in the χT versus T plot.

Just Add Water and Stir. Graduate Chemistry Laboratory, Stony Brook

ERIC Educational Resources Information Center

Yee, Roger

1974-01-01

Using traditional building materials and a fast-track recipe, the architects, acting as construction manager, completed the Graduate Chemistry Laboratory at Stony Brook, New York, two full years ahead of schedule. (Author/MF)

Ontogenetic and diel variation in stream habitat use by brook trout (Salvelinus fontinalis) in a headwater stream

USGS Publications Warehouse

Johnson, J. H.; Ross, R.M.; Dropkin, D.S.; Redell, L.A.

2011-01-01

Although considerable information exists on habitat use by stream salmonids, only a small portion has quantitatively examined diurnal and nocturnal habitat variation. We examined diel variation in habitat use by age-0 and age-1+ brook trout (Salvelinus fontinalis) during summer and autumn in a headwater stream in northern Pennsylvania. Habitat variables measured included cover, depth, substrate, and velocity. The most pronounced diel variation occurred in the use of cover during both seasons. Both age-0 brook trout and age-1+ trout were associated with less cover at night. Age-0 brook trout occupied swifter water during the day than at night during both seasons, but the difference was not significant. Increased cover, depth, and substrate size governed the habitat of age-1+ brook trout. Our findings support the need for a better understanding of diel differences in habitat use of stream salmonids when considering habitat enhancement and protection.

More than a corridor: use of a main stem stream as supplemental foraging habitat by a brook trout metapopulation.

PubMed

Huntsman, Brock M; Petty, J Todd; Sharma, Shikha; Merriam, Eric R

2016-10-01

Coldwater fishes in streams, such as brook trout (Salvelinus fontinalis), typically are headwater specialists that occasionally expand distributions downstream to larger water bodies. It is unclear, however, whether larger streams function simply as dispersal corridors connecting headwater subpopulations, or as critical foraging habitat needed to sustain large mobile brook trout. Stable isotopes (δ(13)C and δ(15)N) and a hierarchical Bayesian mixing model analysis was used to identify brook trout that foraged in main stem versus headwater streams of the Shavers Fork watershed, West Virginia. Headwater subpopulations were composed of headwater and to a lesser extent main stem foraging individuals. However, there was a strong relationship between brook trout size and main stem prey contributions. The average brook trout foraging on headwater prey were limited to 126 mm standard length. This size was identified by mixing models as a point where productivity support switched from headwater to main stem dependency. These results, similar to other studies conducted in this watershed, support the hypothesis that productive main stem habitat maintain large brook trout and potentially facilitates dispersal among headwater subpopulations. Consequently, loss of supplementary main stem foraging habitats may explain loss of large, mobile fish and subsequent isolation of headwater subpopulations in other central Appalachian watersheds.

Invasion by nonnative brook trout in Panther Creek, Idaho: Roles of local habitat quality, biotic resistance, and connectivity to source habitats

USGS Publications Warehouse

Benjamin, Joseph R.; Dunham, Jason B.; Dare, M.R.

2007-01-01

Theoretical models and empirical evidence suggest that the invasion of nonnative species in freshwaters is facilitated through the interaction of three factors: habitat quality, biotic resistance, and connectivity. We measured variables that represented each factor to determine which were associated with the occurrence of nonnative brook trout Salvelinus fontinalis in Panther Creek, a tributary to the Salmon River, Idaho. Habitat variables included measures of summer and winter temperature, instream cover, and channel size. The abundance of native rainbow trout Oncorhynchus mykiss within sampled sites was used as a measure of biotic resistance. We also considered the connectivity of sample sites to unconfined valley bottoms, which were considered habitats that may serve as sources for the spread of established populations of brook trout. We analyzed the occurrence of small (<150‐mm [fork length]) and large (≥150‐mm) brook trout separately, assuming that the former represents an established invasion while accounting for the higher potential mobility of the latter. The occurrence of small brook trout was strongly associated with the proximity of sites to large, unconstrained valley bottoms, providing evidence that such habitats may serve as sources for the spread of brook trout invasion. Within sites, winter degree‐days and maximum summer temperature were positively associated with the occurrence of small brook trout. The occurrence of large brook trout was not related to any of the variables considered, perhaps due to the difficulty of linking site‐specific habitat factors to larger and more mobile individuals. The abundance of rainbow trout was not conclusively associated with the occurrence of either small or large brook trout, providing little support for the role of biotic resistance. Overall, our results suggest that source connectivity and local habitat characteristics, but not biotic resistance, influence the establishment and spread of

Influence of species, size and relative abundance on the outcomes of competitive interactions between brook trout and juvenile coho salmon

USGS Publications Warehouse

Thornton, Emily J; Duda, Jeff; Quinn, Thomas P.

2016-01-01

Resource competition between animals is influenced by a number of factors including the species, size and relative abundance of competing individuals. Stream-dwelling animals often experience variably available food resources, and some employ territorial behaviors to increase their access to food. We investigated the factors that affect dominance between resident, non-native brook trout and recolonizing juvenile coho salmon in the Elwha River, WA, USA, to see if brook trout are likely to disrupt coho salmon recolonization via interference competition. During dyadic laboratory feeding trials, we hypothesized that fish size, not species, would determine which individuals consumed the most food items, and that species would have no effect. We found that species, not size, played a significant role in dominance; coho salmon won 95% of trials, even when only 52% the length of their brook trout competitors. As the pairs of competing fish spent more time together during a trial sequence, coho salmon began to consume more food, and brook trout began to lose more, suggesting that the results of early trials influenced fish performance later. In group trials, we hypothesized that group composition and species would not influence fish foraging success. In single species groups, coho salmon consumed more than brook trout, but the ranges overlapped. Brook trout consumption remained constant through all treatments, but coho salmon consumed more food in treatments with fewer coho salmon, suggesting that coho salmon experienced more intra- than inter-specific competition and that brook trout do not pose a substantial challenge. Based on our results, we think it is unlikely that competition from brook trout will disrupt Elwha River recolonization by coho salmon.

LONGITUDINAL STUDY OF SEMEN QUALITY AFTER INTERMITTENT EXPOSURE TO AIR POLLUTION

EPA Science Inventory

LONGITUDINAL STUDY OF SEMEN QUALITY AFTER INTERMITTENT EXPOSURE TO AIR POLLUTION. J. Rubes*, D. Zudova*, Veterinary Research Institute, Brno, CR, S.G. Selevan*, US EPA/ORD/NCEA, Washington, DC, D.P. Evenson, South Dakota State University, Brookings, SD, and S.D. Perreault, US ...

Complex Transcriptional Control of the Antibiotic Regulator afsS in Streptomyces: PhoP and AfsR Are Overlapping, Competitive Activators▿

PubMed Central

Santos-Beneit, Fernando; Rodríguez-García, Antonio; Martín, Juan F.

2011-01-01

The afsS gene of several Streptomyces species encodes a small sigma factor-like protein that acts as an activator of several pathway-specific regulatory genes (e.g., actII-ORF4 and redD in Streptomyces coelicolor). The two pleiotropic regulators AfsR and PhoP bind to overlapping sequences in the −35 region of the afsS promoter and control its expression. Using mutated afsS promoters containing specific point mutations in the AfsR and PhoP binding sequences, we proved that the overlapping recognition sequences for AfsR and PhoP are displaced by 1 nucleotide. Different nucleotide positions are important for binding of AfsR or PhoP, as shown by electrophoretic mobility shift assays and by reporter studies using the luxAB gene coupled to the different promoters. Mutant promoter M5 (with a nucleotide change at position 5 of the consensus box) binds AfsR but not PhoP with high affinity (named “superAfsR”). Expression of the afsS gene from this promoter led to overproduction of actinorhodin. Mutant promoter M16 binds PhoP with extremely high affinity (“superPhoP”). Studies with ΔafsR and ΔphoP mutants (lacking AfsR and PhoP, respectively) showed that both global regulators are competitive transcriptional activators of afsS. AfsR has greater influence on expression of afsS than PhoP, as shown by reverse transcriptase PCR (RT-PCR) and promoter reporter (luciferase) studies. These two high-level regulators appear to integrate different nutritional signals (particularly phosphate limitation sensed by PhoR), S-adenosylmethionine, and other still unknown environmental signals (leading to AfsR phosphorylation) for the AfsS-mediated control of biosynthesis of secondary metabolites. PMID:21378195

Air Education and Training Command > Home

Science.gov Websites

Media Guide (PDF) USAF Social Media Sites Basic Training Technical Training AF Recruiting Service Flying Air Education and Training Command Air Education and Training Command Join the Air Force Home News Our Experts Search Air Education and Training Command: Continuum of Learning AETC Strategic Plan Ask

Assessing Brook Trout populations in headwater streams of the Adirondack Mountains using environmental DNA -- Summary report

USGS Publications Warehouse

Baldigo, Barry P.; George, Scott D.; Sporn, Lee Ann; Ball, Jacob

2016-01-01

This project evaluated standard fish-survey and environmental DNA (eDNA) sampling methods to determine the ability of eDNA to accurately predict the presence and abundance of resident Brook Trout populations in 40 headwater streams mainly in the western Adirondack Mountains during 2014–2015 (Figure 2). Standard 3-pass electrofishing surveys found that Brook Trout were absent from about 25 percent of study sites, and at low densities in 25 percent of sites, moderate densities in 25 percent of sites, and high densities in 25 percent of sites. Environmental DNA results correctly predicted the presence/absence of Brook Trout in 85.0 to 92.5 percent of study sites and explained 44.0 percent of the variability in density and 24 percent of the variability in biomass of their populations. The findings indicate that eDNA surveys will enable researchers to effectively characterize the presence as well as the abundance of Brook Trout and other species populations in headwater streams across the Adirondack Mountains and elsewhere.

Kinematics of the mosquito terrane, Coldfoot Area, Alaska: Keys to Brooks Range tectonics: Final report, Project No. 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harms, T.A.; Coney, P.J.

1988-04-01

Within the large-scale geometry of the Brooks Range, the Angayucham terrane occurs as a vast overthrust sheet. From the north flank of the Ruby terrane it underlies the Koyukuk basin and stretches north as the roof thrust to the various nappe terranes of the Brooks Range. The tectonic relationship of the Ruby terrane to the south flank of the Brooks Range lies largely obscured beneath the Angayucham in the eastern apex of the Koyukuk basin. The Mosquito terrane occurs as a window through the Angayucham at this juncture. The composition and structures of the Mosquito terrane reveal that is themore » result of shear along a sub-horizontal step or flange within the prominent, through-going dextral strike-slip fault system which cuts across the eastern Koyukuk basin and southeastern Brooks Range. Units of the Mosquito were derived from both the Angayucham and Ruby terranes. A consistent tectonic fabric imposed upon them is kinematically linked to the strike-slip system and indicates a northeasterly direction of transport across the terrane. The presence of Ruby-correlative units within the Mosquito suggests the Ruby underlies the Angayucham and that it is in contact with terrances of the southern Brooks Range at that structural level along high-angle strike-slip faults. These relationships demonstrate that an episode of dextral transpression is the latest in the history of terrane accretion and tectonic evolution of the Brooks Range. 35 refs.« less

Efficacy of environmental DNA to detect and quantify Brook Trout populations in headwater streams of the Adirondack Mountains, New York

USGS Publications Warehouse

Baldigo, Barry P.; Sporn, Lee Ann; George, Scott D.; Ball, Jacob

2016-01-01

Environmental DNA (eDNA) analysis is rapidly evolving as a tool for monitoring the distributions of aquatic species. Detection of species’ populations in streams may be challenging because the persistence time for intact DNA fragments is unknown and because eDNA is diluted and dispersed by dynamic hydrological processes. During 2015, the DNA of Brook Trout Salvelinus fontinalis was analyzed from water samples collected at 40 streams across the Adirondack region of upstate New York, where Brook Trout populations were recently quantified. Study objectives were to evaluate different sampling methods and the ability of eDNA to accurately predict the presence and abundance of resident Brook Trout populations. Results from three-pass electrofishing surveys indicated that Brook Trout were absent from 10 sites and were present in low (<100 fish/0.1 ha), moderate (100–300 fish/0.1 ha), and high (>300 fish/0.1 ha) densities at 9, 11, and 10 sites, respectively. The eDNA results correctly predicted the presence and confirmed the absence of Brook Trout at 85.0–92.5% of the study sites; eDNA also explained 44% of the variability in Brook Trout population density and 24% of the variability in biomass. These findings indicate that eDNA surveys will enable researchers to effectively characterize the presence and abundance of Brook Trout and other species’ populations in headwater streams across the Adirondack region and elsewhere.

A comparative and experimental evaluation of performance of stocked diploid and triploid brook trout

USGS Publications Warehouse

Budy, Phaedra E.; Thiede, G.P.; Dean, A.; Olsen, D.; Rowley, G.

2012-01-01

Despite numerous negative impacts, nonnative trout are still being stocked to provide economically and socially valuable sport fisheries in western mountain lakes. We evaluated relative performance and potential differences in feeding strategy and competitive ability of triploid versus diploid brook trout Salvelinus fontinalis in alpine lakes, as well as behavioral and performance differences of diploid and triploid brook trout in two controlled experimental settings: behavioral experiments in the laboratory and performance evaluations in ponds. Across lakes, catch per unit effort (CPUE) and relative weight (Wr ) were not significantly different between ploidy levels. Mean sizes were also similar between ploidy levels except in two of the larger lakes where diploids attained slightly larger sizes (approximately 20 mm longer). We observed no significant differences between diploids and triploids in diet, diet preference, or trophic structure. Similarly, growth and condition did not differ between ploidy levels in smaller-scale pond experiments, and aggressive behavior did not differ between ploidy levels (fed or unfed fish trials) in the laboratory. Independent of ploidy level, the relative performance of brook trout varied widely among lakes, a pattern that appeared to be a function of lake size or a factor that covaries with lake size such as temperature regime or carrying capacity. In summary, we observed no significant differences in the relative performance of brook trout from either ploidy level across a number of indices, systems, and environmental conditions, nor any indication that one group is more aggressive or a superior competitor than the other. Collectively, these results suggest that triploid brook trout will offer a more risk-averse and promising management opportunity when they are stocked to these lakes and elsewhere to simultaneously meet the needs for the sport fishery and conservation objectives.

75 FR 52374 - National Environmental Policy Act; NASA Glenn Research Center Plum Brook Station Wind Farm Project

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-25

...; NASA Glenn Research Center Plum Brook Station Wind Farm Project AGENCY: National Aeronautics and Space... Environmental Impact Statement (EIS) for the NASA GRC Plum Brook Station Wind Farm Project located near Sandusky... obtain public comments on construction and operation of the wind farm. The purpose of constructing and...

Have brook trout (Salvelinus fontinalis) displaced bull trout (Salvelinus confluentus) along longitudinal gradients in central Idaho streams?

Treesearch

Bruce E. Rieman; James T. Peterson; Deborah L. Myers

2006-01-01

Invasions of non-native brook trout (Salvelinus fontinalis) have the potential for upstream displacement or elimination of bull trout (Salvelinus confluentus) and other native species already threatened by habitat loss. We summarized the distribution and number of bull trout in samples from 12 streams with and without brook trout...

MEDICAL OPERATIONS IN DENIED ENVIRONMENTS (MODE): ARE OUR AF MEDICS READY

DTIC Science & Technology

2016-02-28

modernization spending, more than the sum of the previous three administrations combined.16 Regional actors believe China’s increased A2/AD capabilities...requirements makes achieving the right personnel with sufficient medical readiness especially challenging.37 20 AF planners use unit type codes ... Codes (AFSCs) as a manpower-classification system to group together personnel that have similar duties, skills, and required training. The Air Force

Biodegradation of BOD and ammonia-free using bacterial consortium in aerated fixed film bioreactor (AF2B)

NASA Astrophysics Data System (ADS)

Prayitno, Rulianah, Sri; Saroso, Hadi; Meilany, Diah

2017-06-01

BOD and Ammonia-free (NH3-N) are pollutants of hospital wastewater which often exceed the quality standards. It is because biological processes in wastewater treatment plant (WWTP) have not been effective in degrading BOD and NH3-N. Therefore, a study on factors that influence the biodegradation of BOD and NH3-N by choosing the type of bacteria to improve the mechanisms of biodegradation processes is required. Bacterial consortium is a collection of several types of bacteria obtained from isolation process, which is known to be more effective than a single bacterial in degrading pollutants. On the other hand, AF2B is a type of reactor in wastewater treatment system. The AF2B contains a filter media that has a large surface area so that the biodegradation process of pollutants by microorganism can be improved. The objective of this research is to determine the effect of volume of starter and air supplies on decreasing BOD and NH3-N in hospital wastewater using bacterial consortium in the AF2B on batch process. The research was conducted in three stages: the making of the growth curve of the bacterial consortium, bacterial consortium acclimatization, and hospital wastewater treatment in the AF2B with batch process. The variables used are the volume of starter (65%, 75%, and 85% in volume) and air supplies (2.5, 5, and 7.5 L/min). Meanwhile, the materials used are hospital wastewater, bacterial consortium (Pseudomonas diminuta, Pseudomonas capica, Bacillius sp, and Nitrobacter sp), blower, and AF2B. AF2B is a plastic basin containing a filter media with a wasp-nest shape used as a medium for growing the bacterial consortium. In the process of making the growth curve, a solid form of bacterial consortium was dissolved in sterilized water, then grown in a nutrient broth (NB). Then, shaking and sampling were done at any time to determine the path growth of bacterial consortium. In the acclimatization process, bacterial isolates were grown using hospital wastewater as a

Aft Skirt Move from Hangar AF to BFF

NASA Image and Video Library

2016-09-08

The left hand aft skirt for NASA’s Space Launch System (SLS) rocket arrives at the agency’s Kennedy Space Center in Florida, from the Hangar AF facility at Cape Canaveral Air Force Station. The aft skirt will be transported to the Booster Fabrication Facility. The space shuttle-era aft skirt, was inspected, resurfaced, primed and painted for use on the left hand booster of the SLS rocket for Exploration Mission 1 (EM-1). NASA is preparing for EM-1, deep-space missions, and the journey to Mars.

Aft Skirt Move from Hangar AF to BFF

NASA Image and Video Library

2016-09-08

The left hand aft skirt for NASA’s Space Launch System (SLS) rocket is transported across the Roy D. Bridges Bridge from the Hangar AF facility at Cape Canaveral Air Force Station in Florida, on its way to the Booster Fabrication Facility at the agency’s Kennedy Space Center. The space shuttle-era aft skirt, was inspected, resurfaced, primed and painted for use on the left hand booster of the SLS rocket for Exploration Mission 1 (EM-1). NASA is preparing for EM-1, deep-space missions, and the journey to Mars.

EXPERIMENTAL ACIDIFICATION OF A STREAM TRIBUTARY TO HUBBARD BROOK

EPA Science Inventory

Long (5 mo.) and short-term (1 h to 2 days) effects of acidic pH have been measured in a poorly buffered mountain stream within the Hubbard Brook Experimental Forest, New Hampshire. Over a 5-month period aluminum, calcium, magnesium, and potassium were mobilized into the stream w...

Marginal Experiments: Peter Brook and Stepping out Theatre Company

ERIC Educational Resources Information Center

Harpin, Anna

2010-01-01

This article juxtaposes the recent work of Peter Brook with a Bristol-based mental health service-user collective--Stepping Out Theatre Company. Informed by field-work with the company, this chapter explores the aesthetic and political relationship between professional, experimental theatre work and community-based performance practice. Drawing…

36 CFR 13.1220 - Brooks Camp Developed Area definition.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Brooks Camp Developed Area definition. 13.1220 Section 13.1220 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Katmai National Park and...

Growth rate differences between resident native brook trout and non-native brown trout

USGS Publications Warehouse

Carlson, S.M.; Hendry, A.P.; Letcher, B.H.

2007-01-01

Between species and across season variation in growth was examined by tagging and recapturing individual brook trout Salvelinus fontinalis and brown trout Salmo trutta across seasons in a small stream (West Brook, Massachusetts, U.S.A.). Detailed information on body size and growth are presented to (1) test whether the two species differed in growth within seasons and (2) characterize the seasonal growth patterns for two age classes of each species. Growth differed between species in nearly half of the season- and age-specific comparisons. When growth differed, non-native brown trout grew faster than native brook trout in all but one comparison. Moreover, species differences were most pronounced when overall growth was high during the spring and early summer. These growth differences resulted in size asymmetries that were sustained over the duration of the study. A literature survey also indicated that non-native salmonids typically grow faster than native salmonids when the two occur in sympatry. Taken together, these results suggest that differences in growth are not uncommon for coexisting native and non-native salmonids. ?? 2007 The Authors.

Scale-dependent seasonal pool habitat use by sympatric Wild Brook Trout and Brown Trout populations

USGS Publications Warehouse

Davis, Lori A.; Wagner, Tyler

2016-01-01

Sympatric populations of native Brook Trout Salvelinus fontinalis and naturalized Brown Trout Salmo truttaexist throughout the eastern USA. An understanding of habitat use by sympatric populations is of importance for fisheries management agencies because of the close association between habitat and population dynamics. Moreover, habitat use by stream-dwelling salmonids may be further complicated by several factors, including the potential for fish to display scale-dependent habitat use. Discrete-choice models were used to (1) evaluate fall and early winter daytime habitat use by sympatric Brook Trout and Brown Trout populations based on available residual pool habitat within a stream network and (2) assess the sensitivity of inferred habitat use to changes in the spatial scale of the assumed available habitat. Trout exhibited an overall preference for pool habitats over nonpool habitats; however, the use of pools was nonlinear over time. Brook Trout displayed a greater preference for deep residual pool habitats than for shallow pool and nonpool habitats, whereas Brown Trout selected for all pool habitat categories similarly. Habitat use by both species was found to be scale dependent. At the smallest spatial scale (50 m), habitat use was primarily related to the time of year and fish weight. However, at larger spatial scales (250 and 450 m), habitat use varied over time according to the study stream in which a fish was located. Scale-dependent relationships in seasonal habitat use by Brook Trout and Brown Trout highlight the importance of considering scale when attempting to make inferences about habitat use; fisheries managers may want to consider identifying the appropriate spatial scale when devising actions to restore and protect Brook Trout populations and their habitats.

Chief of Staff of the Air Force

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Chief Master Sergeant of the Air Force

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Landscape-scale evaluation of asymmetric interactions between Brown Trout and Brook Trout using two-species occupancy models

USGS Publications Warehouse

Wagner, Tyler; Jefferson T. Deweber,; Jason Detar,; John A. Sweka,

2013-01-01

Predicting the distribution of native stream fishes is fundamental to the management and conservation of many species. Modeling species distributions often consists of quantifying relationships between species occurrence and abundance data at known locations with environmental data at those locations. However, it is well documented that native stream fish distributions can be altered as a result of asymmetric interactions between dominant exotic and subordinate native species. For example, the naturalized exotic Brown Trout Salmo trutta has been identified as a threat to native Brook Trout Salvelinus fontinalis in the eastern United States. To evaluate large-scale patterns of co-occurrence and to quantify the potential effects of Brown Trout presence on Brook Trout occupancy, we used data from 624 stream sites to fit two-species occupancy models. These models assumed that asymmetric interactions occurred between the two species. In addition, we examined natural and anthropogenic landscape characteristics we hypothesized would be important predictors of occurrence of both species. Estimated occupancy for Brook Trout, from a co-occurrence model with no landscape covariates, at sites with Brown Trout present was substantially lower than sites where Brown Trout were absent. We also observed opposing patterns for Brook and Brown Trout occurrence in relation to percentage forest, impervious surface, and agriculture within the network catchment. Our results are consistent with other studies and suggest that alterations to the landscape, and specifically the transition from a forested catchment to one that contains impervious surface or agriculture, reduces the occurrence probability of wild Brook Trout. Our results, however, also suggest that the presence of Brown Trout results in lower occurrence probability of Brook Trout over a range of anthropogenic landscape characteristics, compared with streams where Brown Trout were absent.

Geomorphic, flood, and groundwater-flow characteristics of Bayfield Peninsula streams, Wisconsin, and implications for brook-trout habitat

USGS Publications Warehouse

Fitzpatrick, Faith A.; Peppler, Marie C.; Saad, David A.; Pratt, Dennis M.; Lenz, Bernard N.

2015-01-01

Available brook-trout habitat is dependent on the locations of groundwater upwellings, the sizes of flood peaks, and sediment loads. Management practices that focus on reducing or slowing runoff from upland areas and increasing channel roughness have potential to reduce flood peaks, erosion, and sedimentation and improve brook-trout habitat in all Bayfield Peninsula streams.

Microhabitat use by brook trout inhabiting small tributaries and a large river main stem: Implications for stream habitat restoration in the central Appalachians

USGS Publications Warehouse

Hansbarger, Jeff L.; Petty, J. Todd; Mazik, Patricia M.

2008-01-01

Brook trout (Salvelinus fontinalis) habitat restoration is needed across a range of stream sizes; however, studies quantifying brook trout habitat preferences in streams of differing sizes are rare. We used radio-telemetry to quantify adult brook trout microhabitat use in a central Appalachian watershed, the upper Shavers Fork of the Cheat River in eastern West Virginia. Our objectives were to: 1) quantify non-random microhabitat use by adult brook trout in the Shavers Fork main stem (drainage area = 32 km2) and an adjacent tributary, Rocky Run (drainage area = 7 km2); and 2) construct stream-specific habitat suitability curves (HSCs) for four important microhabitat variables (depth, average current velocity, maximum current velocity within one meter, and distance to cover). Brook trout used a subset of available microhabitats in both the main stem and Rocky Run: trout tended to occupy microhabitats that were deeper, higher velocity, and closer to cover than expected by chance alone. Although specific microhabitat values differed between the main stem and tributary populations, the overall patterns in brook trout microhabitat use were consistent regardless of stream size. Habitat suitability curves were constructed based on brook trout microhabitat use and will be used to design and monitor the effectiveness of future habitat restoration efforts in the Shavers Fork watershed. Our results suggest that habitat enhancement projects that increase the availability of deep, high velocity microhabitats adjacent to cover would benefit brook trout in both small tributaries and larger river main stems.

Systematics and diversification of Anindobothrium Marques, Brooks & Lasso, 2001 (Eucestoda: Rhinebothriidea)

PubMed Central

Primon, Juliana F.

2017-01-01

Tapeworms of the genus Anindobothrium Marques, Brooks & Lasso, 2001 are found in both marine and Neotropical freshwater stingrays of the family Potamotrygonidae. The patterns of host association within the genus support the most recent hypothesis about the history of diversification of potamotrygonids, which suggests that the ancestor of freshwater lineages of the Potamotrygonidae colonized South American river systems through marine incursion events. Despite the relevance of the genus Anindobothrium to understand the history of colonization and diversification of potamotrygonids, no additional efforts were done to better investigate the phylogenetic relationship of this taxon with other lineages of cestodes since its erection. This study is a result of recent collecting efforts to sample members of the genus in marine and freshwater potamotrygonids that enabled the most extensive documentation of the fauna of Anindobothrium parasitizing species of Styracura de Carvalho, Loboda & da Silva, Potamotrygon schroederi Fernández-Yépez, P. orbignyi (Castelnau) and P. yepezi Castex & Castello from six different countries, representing the eastern Pacific Ocean, Caribbean Sea, and river basins in South America (Rio Negro, Orinoco, and Maracaibo). The newly collected material provided additional specimens for morphological studies and molecular samples for subsequent phylogenetic analyses that allowed us to address the phylogenetic position of Anindobothrium and provide molecular and morphological evidence to recognize two additional species for the genus. The taxonomic actions that followed our analyses included the proposition of a new family, Anindobothriidae fam. n., to accommodate the genus Anindobothrium in the order Rhinebothriidea Healy, Caira, Jensen, Webster & Littlewood, 2009 and the description of two new species—one from the eastern Pacific Ocean, A. carrioni sp. n., and the other from the Caribbean Sea, A. inexpectatum sp. n. In addition, we also present a

AF4 and AF4N protein complexes: recruitment of P-TEFb kinase, their interactome and potential functions

PubMed Central

Scholz, Bastian; Kowarz, Eric; Rössler, Tanja; Ahmad, Khalil; Steinhilber, Dieter; Marschalek, Rolf

2015-01-01

AF4/AFF1 and AF5/AFF4 are the molecular backbone to assemble “super-elongation complexes” (SECs) that have two main functions: (1) control of transcriptional elongation by recruiting the positive transcription elongation factor b (P-TEFb = CyclinT1/CDK9) that is usually stored in inhibitory 7SK RNPs; (2) binding of different histone methyltransferases, like DOT1L, NSD1 and CARM1. This way, transcribed genes obtain specific histone signatures (e.g. H3K79me2/3, H3K36me2) to generate a transcriptional memory system. Here we addressed several questions: how is P-TEFb recruited into SEC, how is the AF4 interactome composed, and what is the function of the naturally occuring AF4N protein variant which exhibits only the first 360 amino acids of the AF4 full-length protein. Noteworthy, shorter protein variants are a specific feature of all AFF protein family members. Here, we demonstrate that full-length AF4 and AF4N are both catalyzing the transition of P-TEFb from 7SK RNP to their N-terminal domain. We have also mapped the protein-protein interaction network within both complexes. In addition, we have first evidence that the AF4N protein also recruits TFIIH and the tumor suppressor MEN1. This indicate that AF4N may have additional functions in transcriptional initiation and in MEN1-dependend transcriptional processes. PMID:26171280

Induction and viability of tetraploids in brook trout (Salvelinus fontinalis)

USDA-ARS?s Scientific Manuscript database

Brook trout (Salvelinus fontinalis) populations are threatened by introduction of invasive species, habitat loss, and habitat degradation in their native range; and are a problem invasive species in western Unites States and Canada, and in Europe. Stocking sterile triploids has been promoted as an ...

Tectonochemistry of the Brooks Range Ophiolite, Alaska

NASA Astrophysics Data System (ADS)

Biasi, J.; Asimow, P. D.; Harris, R. A.

2017-12-01

The Brooks Range Ophiolite (BRO), recently estimated to be 1800km2 in area, is the largest ophiolite in the Western Hemisphere. However, due to its remote location, it remains one of the least studied. Mineral exploration and reconnaissance-level mapping of the ophiolite were done in the 1970s and 1980s. Some chemical analyses were also performed, but since that time the BRO has received little attention. Over the subsequent 25+ years, the study of ophiolites has advanced greatly. These early studies found that the BRO lies in the structurally highest position in the Brooks Range, and its obduction probably coincided with the collision between the Koyukuk Arc and the Arctic-Alaska continental margin. It is therefore important to determine the tectonic setting in which the BRO formed if one wants to understand the tectonic history of the Northern Cordillera during the Jurassic/Cretaceous. Here we present new tectonochemistry data from the BRO. This includes whole-rock data (via XRF), trace element data (via XRF and ICP-MS), and mineral chemistries (via Electron Microprobe). Using immobile element fingerprinting, we constrain the tectonic setting in which the BRO formed and how this information ties in with other events in the Northern Cordillera's history. The fingerprinting results are supplemented by Cr-in-spinel data and Al-in-olivine thermometry.

Is motivation important to brook trout passage through culverts?

USGS Publications Warehouse

Goerig, Elsa; Castro-Santos, Theodore R.

2017-01-01

Culverts can restrict movement of stream-dwelling fish. Motivation to enter and ascend these structures is an essential precursor for successful passage. However, motivation is challenging to quantify. Here, we use attempt rate to assess motivation of 447 brook trout (Salvelinus fontinalis) entering three culverts under a range of hydraulic, environmental, and biological conditions. A passive integrated transponder system allowed for the identification of passage attempts and success of individual fish. Attempt rate was quantified using time-to-event analysis allowing for time-varying covariates and recurrent events. Attempt rate was greatest during the spawning period, at elevated discharge, at dusk, and for longer fish. It decreased during the day and with increasing number of conspecifics downstream of the culvert. Results also show a positive correlation between elevated motivation and successful passage. This study enhances understanding of factors influencing brook trout motivation to ascend culverts and shows that attempt rate is a dynamic phenomenon, variable over time and among individuals. It also presents methods that could be used to investigate other species’ motivation to pass natural or anthropogenic barriers.

Preservation at Stony Brook. Preservation Planning Program. Study Report.

ERIC Educational Resources Information Center

Cook, Donald C.; And Others

This final report is a product of a Preservation Planning Program (PPP) self-study conducted by the State University of New York (SUNY), Stony Brook, working with the Association of Research Libraries' (ARL) Office of Management Studies (OMS). The PPP is designed to put self-help tools into the hands of library staff responsible for developing…

Documentary Linguistics and Computational Linguistics: A Response to Brooks

ERIC Educational Resources Information Center

Bird, Steven; Chiang, David; Frowein, Friedel; Hanke, Florian; Vaswani, Ashish

2015-01-01

In mid-2012, the authors organized a two-week workshop in Papua New Guinea to provide training in basic techniques and technologies for language documentation, and to gain understanding of how these technologies might be improved in the future. An assessment of the workshop was conducted by Brooks with the central idea that the workshop's…

Association between Air Pollution and Emergency Room Visits for Atrial Fibrillation.

PubMed

Solimini, Angelo G; Renzi, Matteo

2017-06-20

Despite the large prevalence in the population, possible factors responsible for the induction of atrial fibrillation (AF) events in susceptible individuals remain incompletely understood. We investigated the association between air pollution levels and emergency department admissions for AF in Rome. We conducted a 14 years' time-series study to evaluate the association between the daily levels of air pollution (particulate matter, PM 10 and PM 2.5 , and nitrogen dioxide, NO₂) and the daily count of emergency accesses for AF (ICD-9 code: 427.31). We applied an over-dispersed conditional Poisson model to analyze the associations at different lags after controlling for time, influenza epidemics, holiday periods, temperature, and relative humidity. Additionally, we evaluated bi-pollutant models by including the other pollutant and the influence of several effect modifiers such as personal characteristics and pre-existing medical conditions. In the period of study, 79,892 individuals were admitted to the emergency departments of Rome hospitals because of AF (on average, 15.6 patients per day: min = 1, max = 36). Air pollution levels were associated with increased AF emergency visits within 24 h of exposure. Effect estimates ranged between 1.4% (0.7-2.3) for a 10 µg/m³ increase of PM 10 to 3% (1.4-4.7) for a 10 µg/m³ increase of PM 2.5 at lag 0-1 day. Those effects were higher in patients ≥75 years for all pollutants, male patients for PM 10 , and female patients for NO₂. The presence of previous cardiovascular conditions, but not other effect modifiers, increase the pollution effects by 5-8% depending on the lag. This study found evidence that air pollution is associated with AF emergency visits in the short term.

Association between Air Pollution and Emergency Room Visits for Atrial Fibrillation

PubMed Central

Solimini, Angelo G.; Renzi, Matteo

2017-01-01

Despite the large prevalence in the population, possible factors responsible for the induction of atrial fibrillation (AF) events in susceptible individuals remain incompletely understood. We investigated the association between air pollution levels and emergency department admissions for AF in Rome. We conducted a 14 years’ time-series study to evaluate the association between the daily levels of air pollution (particulate matter, PM10 and PM2.5, and nitrogen dioxide, NO2) and the daily count of emergency accesses for AF (ICD-9 code: 427.31). We applied an over-dispersed conditional Poisson model to analyze the associations at different lags after controlling for time, influenza epidemics, holiday periods, temperature, and relative humidity. Additionally, we evaluated bi-pollutant models by including the other pollutant and the influence of several effect modifiers such as personal characteristics and pre-existing medical conditions. In the period of study, 79,892 individuals were admitted to the emergency departments of Rome hospitals because of AF (on average, 15.6 patients per day: min = 1, max = 36). Air pollution levels were associated with increased AF emergency visits within 24 h of exposure. Effect estimates ranged between 1.4% (0.7–2.3) for a 10 µg/m3 increase of PM10 to 3% (1.4–4.7) for a 10 µg/m3 increase of PM2.5 at lag 0–1 day. Those effects were higher in patients ≥75 years for all pollutants, male patients for PM10, and female patients for NO2. The presence of previous cardiovascular conditions, but not other effect modifiers, increase the pollution effects by 5–8% depending on the lag. This study found evidence that air pollution is associated with AF emergency visits in the short term. PMID:28632149

Dedication of the Mod-0 Wind Turbine at Plum Brook Station

NASA Image and Video Library

1975-10-21

Energy Research and Development Administration (ERDA) Administrator Robert Seamans addresses the crowd at the dedication ceremony for the Mod-0 100-kilowatt wind turbine at the National Aeronautics and Space Administration’s (NASA) Plum Brook Station. The wind turbine program was a joint NASA/ERDA effort to develop less expensive forms of energy during the 1970s. NASA Lewis was able to use its experience with aerodynamics, powerplants, and energy transfer to develop efficient and cost-effective wind energy systems. The Plum Brook wind turbine was the first of a series of increasingly powerful NASA-ERDA wind turbines built around the nation. From left to right: Congressional Committee aide John Dugan, retired S. Morgan Smith Company chief engineer Carl Wilcox, windmill pioneer Beauchamp Smith, NASA Administrator James Fletcher, Seamans, and Lewis Center Director Bruce Lundin. The three men to the right are unidentified.

Fine Sediment Effects on Brook Trout Eggs in Laboratory Streams

Treesearch

David G. Argent; Patricia A. Flebbe

1999-01-01

This study was designed to determine effects of different fine sediments (0.43-0.85 mm in diameter) on survival of brook trout (Salvelinus fontinalis) eggs during early developmental stages under laboratory conditions. Intragravel permeability and dissolved oxygen declined with increasing fine sediment amounts. Survival at each developmental stage...

Clinical and Economic Implications of AF Related Stroke.

PubMed

Ali, Ali N; Abdelhafiz, Ahmed

2016-01-01

A major cause of morbidity and mortality among patients with atrial fibrillation (AF) relates to the increased risk of stroke. The burden of illness that AF imparts on stroke is likely to increase with our aging populations and increasingly sophisticated cardiac monitoring techniques. Understanding the clinical and economic differences between AF related ischaemic stroke and non-AF related stroke is important if we are to improve future cost effectiveness analyses of potential preventative treatments, but also to help educate clinical and policy decision makers on use or availability of treatments to prevent AF related stroke. In this article we review the existing evidence that highlights differences in the clinical characteristics and outcomes between AF and non-AF stroke, as well as differences in their economic impact and discuss ways to improve future economic analyses.

Drought-induced stomatal closure probably cannot explain divergent white spruce growth in the Brooks Range, Alaska, USA.

PubMed

Brownlee, Annalis H; Sullivan, Patrick F; Csank, Adam Z; Sveinbjörnsson, Bjartmar; Ellison, Sarah B Z

2016-01-01

Increment cores from the boreal forest have long been used to reconstruct past climates. However, in recent years, numerous studies have revealed a deterioration of the correlation between temperature and tree growth that is commonly referred to as divergence. In the Brooks Range of northern Alaska, USA, studies of white spruce (Picea glauca) revealed that trees in the west generally showed positive growth trends, while trees in the central and eastern Brooks Range showed mixed and negative trends during late 20th century warming. The growing season climate of the eastern Brooks Range is thought to be drier than the west. On this basis, divergent tree growth in the eastern Brooks Range has been attributed to drought stress. To investigate the hypothesis that drought-induced stomatal closure can explain divergence in the Brooks Range, we synthesized all of the Brooks Range white spruce data available in the International Tree Ring Data Bank (ITRDB) and collected increment cores from our primary sites in each of four watersheds along a west-to-east gradient near the Arctic treeline. For cores from our sites, we measured ring widths and calculated carbon isotope discrimination (δ13C), intrinsic water-use efficiency (iWUE), and needle intercellular CO2 concentration (C(i)) from δ13C in tree-ring alpha-cellulose. We hypothesized that trees exhibiting divergence would show a corresponding decline in δ13C, a decline in C(i), and a strong increase in iWUE. Consistent with the ITRDB data, trees at our western and central sites generally showed an increase in the strength of the temperature-growth correlation during late 20th century warming, while trees at our eastern site showed strong divergence. Divergent tree growth was not, however, associated with declining δ13C. Meanwhile, estimates of C(i) showed a strong increase at all of our study sites, indicating that more substrate was available for photosynthesis in the early 21st than in the early 20th century. Our

TEMPORAL TRENDS IN ETHOXYRESORUFIN-O-DEETHYLASE ACTIVITY OF BROOK TROUT (SALVELINUS FONTINALIS) FED 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN

EPA Science Inventory

Changes in ethoxyresorufin-O-deethylase (EROD) activity were monitored through an extended 6-month dietary exposure to determine the relationship between EROD activity and uptake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in brook trout, Salvelinus fontinalis. Brook trout were...

TEMPORAL TRENDS IN ETHOXYRESORUFIN-O-DEETHYLASE ACITIVITY OF BROOK TROUT (SALVELINUS FONTINALIS) FED 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN

EPA Science Inventory

Changes in ethoxyresorufin-0-deethylase (EROD) activity were monitored through an extended 6-month dietary exposure to determine the relationship between EROD activity and uptake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in brook trout, Salvelinus fontinalis. Brook trout wer...

NASA's Hydrogen Outpost: The Rocket Systems Area at Plum Brook Station

NASA Technical Reports Server (NTRS)

Arrighi, Robert S.

2016-01-01

"There was pretty much a general knowledge about hydrogen and its capabilities," recalled former researcher Robert Graham. "The question was, could you use it in a rocket engine? Do we have the technology to handle it? How will it cool? Will it produce so much heat release that we can't cool the engine? These were the questions that we had to address." The National Aeronautics and Space Administration's (NASA) Glenn Research Center, referred to historically as the Lewis Research Center, made a concerted effort to answer these and related questions in the 1950s and 1960s. The center played a critical role transforming hydrogen's theoretical potential into a flight-ready propellant. Since then NASA has utilized liquid hydrogen to send humans and robots to the Moon, propel dozens of spacecraft across the universe, orbit scores of satellite systems, and power 135 space shuttle flights. Rocket pioneers had recognized hydrogen's potential early on, but its extremely low boiling temperature and low density made it impracticable as a fuel. The Lewis laboratory first demonstrated that liquid hydrogen could be safely utilized in rocket and aircraft propulsion systems, then perfected techniques to store, pump, and cleanly burn the fuel, as well as use it to cool the engine. The Rocket Systems Area at Lewis's remote testing area, Plum Brook Station, played a little known, but important role in the center's hydrogen research efforts. This publication focuses on the activities at the Rocket Systems Area, but it also discusses hydrogen's role in NASA's space program and Lewis's overall hydrogen work. The Rocket Systems Area included nine physically modest test sites and three test stands dedicated to liquid-hydrogen-related research. In 1962 Cleveland Plain Dealer reporter Karl Abram claimed, "The rocket facility looks more like a petroleum refinery. Its test rigs sprout pipes, valves and tanks. During the night test runs, excess hydrogen is burned from special stacks in the best

Permian deposition in the north central Brooks Range, Alaska Constraints for tectonic reconstructions

USGS Publications Warehouse

Adams, K.E.; Mull, C.G.; Crowder, R.K.

1997-01-01

Two opposing tectonic models have been offered to explain the regional structural relations in the north central Brooks Range fold-thrust belt of northern Alaska. The first suggests that rocks of the northern Endicott Mountains were thrust from south to north over the area of the present Mount Doonerak high and are therefore highly allochthonous. The second implies that the rocks of the northern Endicott Mountains were deposited in a basin that lay north of the Mount Doonerak high and later were thrust a short distance southward onto the northern flank of the high and are thus parautochthonous. To provide stratigraphic constraints for these models, this study examines Permian facies of the north central Brooks Range. Permian rocks in the north central Brooks Range comprise a thin (40 to 160 m thick), fining-upward succession of clastic, storm-influenced shelf deposits. When the rocks of the northern Endicott Mountains are restored south of the Mount Doonerak area, a minimum distance of 80 km, the Permian deposits grade systematically from distal facies (Siksikpuk Formation) in the southwest to proximal facies (Echooka Formation) in the northeast. Facies trends in the reconstructed Permian basin include, from southwest to northeast, (1) an increase in carbonate content and corresponding decrease in silica content, (2) a general darkening and thickening of shaley intervals, (3) an increase in proximal features of storm beds, including coarser, thicker, more abundant, and more closely spaced beds, and (4) an increase in abundance and diversity of the faunal assemblage with a corresponding decrease in age. These stratigraphic relations imply that rocks of the northern Endicott Mountains are allochthonous and structurally overlie a proximal stratigraphic succession similar to that exposed in the Mount Doonerak area and northeastern Brooks Range. Copyright 1997 by the American Geophysical Union.

Brook trout distributional response to unconventional oil and gas development: Landscape context matters

USGS Publications Warehouse

Merriam, Eric R.; Petty, J. Todd; Maloney, Kelly O.; Young, John A.; Faulkner, Stephen; Slonecker, Terry; Milheim, Lesley E.; Hailegiorgis, Atesmachew; Niles, Jonathan M.

2018-01-01

We conducted a large-scale assessment of unconventional oil and gas (UOG) development effects on brook trout (Salvelinus fontinalis) distribution. We compiled 2231 brook trout collection records from the Upper Susquehanna River Watershed, USA. We used boosted regression tree (BRT) analysis to predict occurrence probability at the 1:24,000 stream-segment scale as a function of natural and anthropogenic landscape and climatic attributes. We then evaluated the importance of landscape context (i.e., pre-existing natural habitat quality and anthropogenic degradation) in modulating the effects of UOG on brook trout distribution under UOG development scenarios. BRT made use of 5 anthropogenic (28% relative influence) and 7 natural (72% relative influence) variables to model occurrence with a high degree of accuracy [Area Under the Receiver Operating Curve (AUC) = 0.85 and cross-validated AUC = 0.81]. UOG development impacted 11% (n = 2784) of streams and resulted in a loss of predicted occurrence in 126 (4%). Most streams impacted by UOG had unsuitable underlying natural habitat quality (n = 1220; 44%). Brook trout were predicted to be absent from an additional 26% (n = 733) of streams due to pre-existing non-UOG land uses (i.e., agriculture, residential and commercial development, or historic mining). Streams with a predicted and observed (via existing pre- and post-disturbance fish sampling records) loss of occurrence due to UOG tended to have intermediate natural habitat quality and/or intermediate levels of non-UOG stress. Simulated development of permitted but undeveloped UOG wells (n = 943) resulted in a loss of predicted occurrence in 27 additional streams. Loss of occurrence was strongly dependent upon landscape context, suggesting effects of current and future UOG development are likely most relevant in streams near the probability threshold due to pre-existing habitat degradation.

Sedimentology and stratigraphy of the Kanayut Conglomerate, central and western Brooks Range, Alaska; report of 1981 field season

USGS Publications Warehouse

Nilsen, T.H.; Moore, T.E.

1982-01-01

The Upper Devonian and Lower Mississippian(?) Kanayut Conglomerate forms a major stratigraphic unit along the crest of the Brooks Range of northern Alaska. It crops out for an east-west distance of about 900 km and a north-south distance of about 65 km. The Kanayut is wholly allochthonous and has probably been transported northward on a series of thrust plates. The Kanayut is as thick as 2,600 m in the east-central Brooks Range. It thins and fines to the south and west. The Kanayut forms the middle part of the allochthonous sequence of the Endicott Group, an Upper Devonian and Mississippian clastic sequence underlain by platform limestones of the Baird Group and overlain by platform limestone, carbonaceous shale, and black chert of the Lisburne Group. The Kanayut overlies the marine Upper Devonian Noatak Sandstone or, where it is missing, the marine Upper Devonian Hunt Fork Shale. It is overlain by the marine Mississippian Kayak Shale. The Kanayut Conglomerate forms the fluvial part of a large, coarse-grained delta that prograded to the southwest in Late Devonian time and retreated in Early Mississippian time. Four sections of the Kanayut Conglomerate in the central Brooks Range and five in the western Brooks Range were measured in 1981. The sections from the western Brooks Range document the presence of fluvial cycles in the Kanayut as far west as the shores of the Chukchi Sea. The Kanayut in this area is generally finer grained than it is in the central and eastern Brooks Range, having a maximum clast size of 3 cm. It is probably about 300 m thick. The upper and lower contacts of the Kanayut are gradational. The lower Kanayut contains calcareous, marine-influenced sandstone within channel deposits, and the upper Kanayut contains probable marine interdistributary-bay shale sequences. The members of the Kanayut Conglomerate cannot be differentiated in this region. In the central Brooks Range, sections of the Kanayut Conglomerate at Siavlat Mountain and Kakivilak

Brook trout movement in response to temperature, flow, and thermal refugia within a complex Appalachian riverscape

USGS Publications Warehouse

Petty, J. Todd; Hansbarger, Jeff L.; Huntsman, Brock M.; Mazik, Patricia M.

2012-01-01

We quantified movements of brook trout Salvelinus fontinalis and brown trout Salmo trutta in a complex riverscape characterized by a large, open-canopy main stem and a small, closed-canopy tributary in eastern West Virginia, USA. Our objectives were to quantify the overall rate of trout movement and relate movement behaviors to variation in streamflow, water temperature, and access to coldwater refugia. The study area experienced extremely high seasonal, yearly, and among-stream variability in water temperature and flow. The relative mobility of brook trout within the upper Shavers Fork watershed varied significantly depending on whether individuals resided within the larger main stem or the smaller tributary. The movement rate of trout inhabiting the main stem during summer months (50 m/d) was an order of magnitude higher than that of tributary fish (2 m/d). Movement rates of main-stem-resident brook trout during summer were correlated with the maximum water temperature experienced by the fish and with the fish's initial distance from a known coldwater source. For main-stem trout, use of microhabitats closer to cover was higher during extremely warm periods than during cooler periods; use of microhabitats closer to cover during warm periods was also greater for main-stem trout than for tributary inhabitants. Main-stem-resident trout were never observed in water exceeding 19.5°C. Our study provides some of the first data on brook trout movements in a large Appalachian river system and underscores the importance of managing trout fisheries in a riverscape context. Brook trout conservation in this region will depend on restoration and protection of coldwater refugia in larger river main stems as well as removal of barriers to trout movement near tributary and main-stem confluences.

Air Force Research Laboratory

DTIC Science & Technology

2009-06-08

Air Force Research Laboratory 8 June 2009 Mr. Leo Marple Ai F R h L b t r orce esearc a ora ory Leo.Marple@wpafb.af.mil DISTRIBUTION STATEMENT A...TITLE AND SUBTITLE Air Force Research Laboratory 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER...5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Air Force Research Laboratory ,Wright

LONG-TERM EFFECTS OF ZINC EXPOSURES ON BROOK TROUT ('SALVELINUS FONTINALIS')

EPA Science Inventory

Exposure of three generations of brook trout (Salvelinus fontinalis) to zinc concentrations ranging from 2.6 to 534 micrograms/liter produced no significant harmful effects. During a separate exposure of embryos and larvae, 1,368 micrograms Zn/liter significantly reduced (P = 0.0...

Bone marrow mesenchymal stem cells from infants with MLL-AF4+ acute leukemia harbor and express the MLL-AF4 fusion gene

PubMed Central

Catalina, Purificación; Rodríguez, René; Melen, Gustavo J.; Bueno, Clara; Arriero, Mar; García-Sánchez, Félix; Lassaletta, Alvaro; García-Sanz, Ramón

2009-01-01

MLL-AF4 fusion is a hallmark genetic abnormality in infant B-acute lymphoblastic leukemia (B-ALL) known to arise in utero. The cellular origin of leukemic fusion genes during human development is difficult to ascertain. The bone marrow (BM) microenvironment plays an important role in the pathogenesis of several hematological malignances. BM mesenchymal stem cells (BM-MSC) from 38 children diagnosed with cytogenetically different acute leukemias were screened for leukemic fusion genes. Fusion genes were absent in BM-MSCs of childhood leukemias carrying TEL-AML1, BCR-ABL, AML1-ETO, MLL-AF9, MLL-AF10, MLL-ENL or hyperdiploidy. However, MLL-AF4 was detected and expressed in BM-MSCs from all cases of MLL-AF4+ B-ALL. Unlike leukemic blasts, MLL-AF4+ BM-MSCs did not display monoclonal Ig gene rearrangements. Endogenous or ectopic expression of MLL-AF4 exerted no effect on MSC culture homeostasis. These findings suggest that MSCs may be in part tumor-related, highlighting an unrecognized role of the BM milieu on the pathogenesis of MLL-AF4+ B-ALL. MLL-AF4 itself is not sufficient for MSC transformation and the expression of MLL-AF4 in MSCs is compatible with a mesenchymal phenotype, suggesting a differential impact in the hematopoietic system and mesenchyme. The absence of monoclonal rearrangements in MLL-AF4+ BM-MSCs precludes the possibility of cellular plasticity or de-differentiation of B-ALL blasts and suggests that MLL-AF4 might arise in a population of prehematopoietic precursors. PMID:19995953

Spatial structure of morphological and neutral genetic variation in Brook Trout

USGS Publications Warehouse

Kazyak, David C.; Hilderbrand, Robert H.; Keller, Stephen R.; Colaw, Mark C.; Holloway, Amanda E.; Morgan, Raymond P.; King, Timothy L.

2015-01-01

Brook Trout Salvelinus fontinalis exhibit exceptional levels of life history variation, remarkable genetic variability, and fine-scale population structure. In many cases, neighboring populations may be highly differentiated from one another to an extent that is comparable with species-level distinctions in other taxa. Although genetic samples have been collected from hundreds of populations and tens of thousands of individuals, little is known about whether differentiation at neutral markers reflects phenotypic differences among Brook Trout populations. We compared differentiation in morphology and neutral molecular markers among populations from four geographically proximate locations (all within 24 km) to examine how genetic diversity covaries with morphology. We found significant differences among and/or within streams for all three morphological axes examined and identified the source stream of many individuals based on morphology (52.3% classification efficiency). Although molecular and morphological differentiation among streams ranged considerably (mean pairwise FST: 0.023–0.264; pairwise PST: 0.000–0.339), the two measures were not significantly correlated. While in some cases morphological characters appear to have diverged to a greater extent than expected by neutral genetic drift, many traits were conserved to a greater extent than were neutral genetic markers. Thus, while Brook Trout exhibit fine-scale spatial patterns in both morphology and neutral genetic diversity, these types of biological variabilities are being structured by different ecological and evolutionary processes. The relative influences of genetic drift versus selection and phenotypic plasticity in shaping morphology appear to vary among populations occupying nearby streams.

Mindfulness over matter > U.S. Air Force > Article Display

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Air Force Research Laboratory’s Focused Long Term Challenges

DTIC Science & Technology

2008-04-01

Air Force Research Laboratory ( AFRL ) mission is to provide support to the Air Force (AF) and the warfighters with... Air Force Research Laboratory’s Focused Long Term Challenges Leo J Rose Munitions Directorate, Air Force Research Laboratory , 101 W Eglin Blvd...This technology vision, which was born in our Air Force Research Laboratory , builds on the Air Force’s traditional kill

STBC AF relay for unmanned aircraft system

NASA Astrophysics Data System (ADS)

Adachi, Fumiyuki; Miyazaki, Hiroyuki; Endo, Chikara

2015-01-01

If a large scale disaster similar to the Great East Japan Earthquake 2011 happens, some areas may be isolated from the communications network. Recently, unmanned aircraft system (UAS) based wireless relay communication has been attracting much attention since it is able to quickly re-establish the connection between isolated areas and the network. However, the channel between ground station (GS) and unmanned aircraft (UA) is unreliable due to UA's swing motion and as consequence, the relay communication quality degrades. In this paper, we introduce space-time block coded (STBC) amplify-and-forward (AF) relay for UAS based wireless relay communication to improve relay communication quality. A group of UAs forms single frequency network (SFN) to perform STBC-AF cooperative relay. In STBC-AF relay, only conjugate operation, block exchange and amplifying are required at UAs. Therefore, STBC-AF relay improves the relay communication quality while alleviating the complexity problem at UAs. It is shown by computer simulation that STBC-AF relay can achieve better throughput performance than conventional AF relay.

Quantitative Analysis of Contributing Factors Affecting Patient Satisfaction in Family Medicine Service Clinics at Brooke Army Medical Center

DTIC Science & Technology

2008-06-06

Predictors of patient satisfaction for Brooke Army Medical Center Family Medicine Service primary care clinics was performed. Data was obtained from...Factors Affecting Patient Satisfaction in Family Medicine Service Clinics at Brooke Army Medical Center Presented to MAJ Eric Schmacker, Ph.D. In...study. All patients ’ medical information was protected at all times and under no circumstances will be discussed or released to any outside agency

Environmental DNA particle size distribution from Brook Trout (Salvelinus fontinalis)

Treesearch

Taylor M. Wilcox; Kevin S. McKelvey; Michael K. Young; Winsor H. Lowe; Michael K. Schwartz

2015-01-01

Environmental DNA (eDNA) sampling has become a widespread approach for detecting aquatic animals with high potential for improving conservation biology. However, little research has been done to determine the size of particles targeted by eDNA surveys. In this study, we conduct particle distribution analysis of eDNA from a captive Brook Trout (Salvelinus fontinalis) in...

Annual cycles of soil and water temperatures at Hubbard Brook

Treesearch

C. Anthony Federer

1973-01-01

Soil temperatures in the Hubbard Brook Experimental Forest in central New Hampshire decline very slowly from December to March and are restricted from falling below OºC by insulation of snow and organic matter. Soil in the hardwood forest on a moderate south slope warms rapidly in the spring leafless period after snowmelt and reaches a maximum temperature in...

Effects of temperature on survival and development of early life stage Pacific and western brook lampreys

USGS Publications Warehouse

Meeuwig, M.H.; Bayer, J.M.; Seelye, J.G.

2005-01-01

We examined the effects of temperature (10, 14, 18, and 22??C) on survival and development of Pacific lampreys Lampetra tridentata and western brook lampreys L. richardsoni during embryological and early larval stages. The temperature for zero development was estimated for each species, and the response to temperature was measured as the proportion of individuals surviving to hatch, surviving to the larval stage, and exhibiting abnormalities at the larval stage (i.e., malformations of the body). The estimated temperature for zero development was 4.850C for Pacific lampreys and 4.97??C for western brook lampreys. Survival was greatest at 18??C, followed by 14, 10, and 22??C, significant differences being observed between 22??C and the other temperatures. Overall survival was significantly greater for western brook lampreys than for Pacific lampreys; however, the overall difference in proportion of individuals surviving was only 0.02. Overall survival significantly decreased from the time of hatch (proportion surviving = 0.85) to the larval stage (0.82; i.e., during the free-embryo stage). The proportion of individuals exhibiting abnormalities at the larval stage was greatest at 22??C, followed by 18, 10, and 14??C, significant differences being observed between 22??C and the other temperatures. These data provide baseline information on the thermal requirements of early life stage Pacific and western brook lampreys and will aid in assessment and prediction of suitable spawning and rearing habitats for these species.

Flood of October 8 and 9, 2005, on Cold River in Walpole, Langdon, and Alstead and on Warren Brook in Alstead, New Hampshire

USGS Publications Warehouse

Olson, Scott A.

2006-01-01

Southwestern New Hampshire experienced damaging flooding on October 8 and 9, 2005. The flooding was the result of a storm producing at least 7 inches of rain in a 30-hour period. The heavy, intense rainfall resulted in runoff and severe flooding, especially in regions of steep topography that are vulnerable to flash flooding. Some of the worst property damage was in the towns of Alstead, Langdon, and Walpole, New Hampshire along Cold River and Warren Brook. Warren Brook was severely flooded and had flows that exceeded a 100-year recurrence interval upstream of Cooper Hill Road. Downstream of Cooper Hill Road, the flooding was worsened as a result of a sudden release of impounded water, making the flood levels greater than what would be experienced from a 500-year recurrence-interval flood. Along Cold River, upstream of its confluence with Warren Brook, flooding was at approximately a 100-year recurrence interval. Downstream of the confluence of Cold River and Warren Brook, the streamflows, which were swollen by the surge of water from Warren Brook, exceeded a 500year recurrence interval.

Interior of the Plum Brook Reactor Facility

NASA Image and Video Library

1961-02-21

A view inside the 55-foot high containment vessel of the National Aeronautics and Space Administration (NASA) Plum Brook Reactor Facility in Sandusky, Ohio. The 60-megawatt test reactor went critical for the first time in 1961 and began its full-power research operations in 1963. From 1961 to 1973, this reactor performed some of the nation’s most advanced nuclear research. The reactor was designed to determine the behavior of metals and other materials after long durations of irradiation. The materials would be used to construct a nuclear-powered rocket. The reactor core, where the chain reaction occurred, sat at the bottom of the tubular pressure vessel, seen here at the center of the shielding pool. The core contained fuel rods with uranium isotopes. A cooling system was needed to reduce the heat levels during the reaction. A neutron-impervious reflector was also employed to send many of the neutrons back to the core. The Plum Brook Reactor Facility was constructed from high-density concrete and steel to prevent the excess neutrons from escaping the facility, but the water in the pool shielded most of the radiation. The water, found in three of the four quadrants served as a reflector, moderator, and coolant. In this photograph, the three 20-ton protective shrapnel shields and hatch have been removed from the top of the pressure tank revealing the reactor tank. An overhead crane could be manipulated to reach any section of this room. It was used to remove the shrapnel shields and transfer equipment.

B-52 Stratofortress > U.S. Air Force > Fact Sheet Display

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Proposed standard-weight equations for brook trout

USGS Publications Warehouse

Hyatt, M.W.; Hubert, W.A.

2001-01-01

Weight and length data were obtained for 113 populations of brook trout Salvelinus fontinalis across the species' geographic range in North America to estimate a standard-weight (Ws) equation for this species. Estimation was done by applying the regression-line-percentile technique to fish of 120-620 mm total length (TL). The proposed metric-unit (g and mm) equation is log10Ws = -5.186 + 3.103 log10TL; the English-unit (lb and in) equivalent is log10Ws = -3.483 + 3.103 log10TL. No systematic length bias was evident in the relative-weight values calculated from these equations.

Chemistry of precipitation, streamwater, and lakewater from the Hubbard Brook Ecosystem Study: a record of sampling protocols and analytical procedures

Treesearch

Donald C. Buso; Gene E. Likens; John S. Eaton

2000-01-01

The Hubbard Brook Ecosystem Study (HBES), begun in 1963, is a long-term effort to understand the structure, function and change in forest watersheds and associated aquatic ecosystems at the Hubbard Brook Experimental Forest in New Hampshire. Chemical analyses of streamwater and precipitation collections began in 1963, and analyses of lakewater collections began in 1967...

The Stony Brook/SMARTS Atlas of (mostly) Southern Novae

NASA Astrophysics Data System (ADS)

Walter, F. M.

2014-12-01

The Stony Brook/SMARTS Atlas of (mostly) Southern Novae is an on-line compendium of data on 69 novae, mostly in the southern hemisphere, observed since 2003 April. The data consist of low resolution spectra (400< R <4000) and optical and near-IR photometry obtained with the SMARTS telescopes. I shall describe the atlas and the data, and then present some examples of the data analyzes being undertaken with this synoptic data set.

How New National Air Data System Affects ECHO Data ...

EPA Pesticide Factsheets

The ECHO website is displaying Clean Air Act stationary source data from the modernized national data management system, ICIS-Air. The old system, AFS was retired in October 2014. Answers to frequently asked questions about the data system transition are presented on this page.

An Updated Version of the U.S. Air Force Multi-Attribute Task Battery (AF-MATB)

DTIC Science & Technology

2014-08-01

assessing human performance in a controlled multitask environment. The most recent release of AF-MATB contains numerous improvements and additions...Strategic Behavior, MATB, Multitasking , Task Battery, Simulator, Multi-Attribute Task Battery, Automation 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF...performance and multitasking strategy. As a result, a specific Information Throughput (IT) Mode was designed to customize the task to fit the Human

Measuring Air Force Contracting Customer Satisfaction

DTIC Science & Technology

2015-12-01

NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT MEASURING AIR FORCE CONTRACTING CUSTOMER SATISFACTION ...... satisfaction elements should be included in a standardized tool that measures the level of customer satisfaction for AF Contracting’s external and

Stony Brook's Graduate Courses in Clear, Vivid, Conversational Communication

NASA Astrophysics Data System (ADS)

Bass, E.

2011-12-01

Graduate students in the sciences at Stony Brook University are taking for-credit courses to learn to communicate more effectively about science with people outside their disciplines, including public officials, the press, students, potential funders and employers, colleagues in other fields, and the general public. Five Communicating Science courses are offered; two more will be added in January, 2012. The courses are offered by the School of Journalism and developed by the Center for Communicating Science (CCS). This interdisciplinary center was founded in 2009, with the participation of Alan Alda, the actor, writer, director and longtime advocate for science, who is a Visiting Professor at Stony Brook. At the core of the program are three 1-credit (14-hour) modules that rely on experiential learning, repeated practice and immediate, interactive feedback. In Distilling Your Message, students practice speaking clearly, vividly and conversationally about their work at different levels of complexity and formality to different audiences, using storytelling techniques where appropriate. In Writing for the Public, they extend these skills into writing. In Improvisation for Scientists, the most unconventional of the courses, students play improvisational theater games to help themselves connect more directly, personally and responsively with their audiences. In their first two semesters, the courses are expected to serve about 90 students, taking a total of about 180 credits. Most of the courses have filled quickly, mixing master's and doctoral students from more than a dozen fields, including marine and atmospheric sciences. Three to six credits of Communicating Science courses are required for students in two programs, an MA in Marine Conservation and Policy and an Advanced Certificate in Health Communications. The content and methods of the courses are based largely on lessons learned from evaluations of all-day workshops that CCS has conducted for more than 250

Securing the High Ground: Dominant Combat Air Force for America. 2008 Combat Air Force Strategic Plan

DTIC Science & Technology

2008-07-28

continue to be beyond our technical ability to realize aggresively pursue advanced technical solutions to stay at the leading edge of technological...inherent to each caf Way and to seek continual improvement through exploration of innovative concepts, advanced capabilities, game -changing...available online at the air force portal: https://wwwd.my.af.mil/afknprod/strat_plan COMBAT AIR FORCE STRATEGIC PLAN Points of Contact securing the high

MAJOR GENERAL PETER E. GERSTEN > U.S. Air Force > Biography Display

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Spatial and temporal Brook Trout density dynamics: Implications for conservation, management, and monitoring

USGS Publications Warehouse

Wagner, Tyler; Jefferson T. Deweber,; Jason Detar,; Kristine, David; John A. Sweka,

2014-01-01

Many potential stressors to aquatic environments operate over large spatial scales, prompting the need to assess and monitor both site-specific and regional dynamics of fish populations. We used hierarchical Bayesian models to evaluate the spatial and temporal variability in density and capture probability of age-1 and older Brook Trout Salvelinus fontinalis from three-pass removal data collected at 291 sites over a 37-year time period (1975–2011) in Pennsylvania streams. There was high between-year variability in density, with annual posterior means ranging from 2.1 to 10.2 fish/100 m2; however, there was no significant long-term linear trend. Brook Trout density was positively correlated with elevation and negatively correlated with percent developed land use in the network catchment. Probability of capture did not vary substantially across sites or years but was negatively correlated with mean stream width. Because of the low spatiotemporal variation in capture probability and a strong correlation between first-pass CPUE (catch/min) and three-pass removal density estimates, the use of an abundance index based on first-pass CPUE could represent a cost-effective alternative to conducting multiple-pass removal sampling for some Brook Trout monitoring and assessment objectives. Single-pass indices may be particularly relevant for monitoring objectives that do not require precise site-specific estimates, such as regional monitoring programs that are designed to detect long-term linear trends in density.

The United States Air Force Academy: A Bibliography 1954 - 1964

DTIC Science & Technology

1966-01-01

August 1958. 498 Stringer, Roger. " Pro Nobis Astra" (Class of 󈨁 selects its ring), Talon 5;5, May 1960. 499 Trotogott, Pete. Cadet...relate to establishing an air academy. These are not included since they have no specific bearing on the Academy as it now exists. The Library staff...Newsletter AF Times - Air Force Times Air Cond Heat & Ven - Air Conditioning, Heating, and Venti- lating Air Force Airman Air Power Historian

Comment on Meisner (1990): Effect of climatic warming on the southern margins of the native range of brook trout, Salvelinus fontinalis

Treesearch

Patricia A. Flebbe

1993-01-01

Meisner (1990) proposed in the Journall that the lower elevational margin of brook trout (Salvelinus fontinalis), in the southern part of their native range is related to the 15 degrees C groundwater isotherm, based on a modelled relationship between minimum elevations at which brook trout occur in this part of the native range and...

Victory From Above. Air Power Theory and the Conduct of Operations Desert Shield and Desert Storm

DTIC Science & Technology

1994-06-01

Or Why Did We Do It That Way?’ in Air Power. CollectedffEsay on Doctrine ed. Andrew Vallance (London: Her Askleatys Stationery Office, 1990), 17-30...York: National Strategy Information Center, 1983); Richard K Bette, Surprise Attack: Lessons for Defense Planning (Washington, D.C.: Brookings...Chart MI.H.3; Cordesman, 570. 21. Richard Mackenxie, "A Conversation with Chuck Homer,’ Air Force Magazine, June 1991, 57-58; Blackwell, 85-86. 22

Chemical and morphological distinctions between vertical and lateral podzolization at Hubbard Brook

Treesearch

Rebecca R. Bourgault; Donald S. Ross; Scott W. Bailey

2015-01-01

Classical podzolization studies assumed vertical percolation and pedon-scale horizon development. However, hillslope-scale lateral podzolization also occurs where lateral subsurface water flux predominates. In this hydropedologic study, 99 podzols were observed in Watershed 3, Hubbard Brook Experimental Forest, New Hampshire. Soil horizon samples were extracted with...

AF-Shell 1.0 User Guide

NASA Technical Reports Server (NTRS)

McElroy, Mark W.

2017-01-01

This document serves as a user guide for the AF-Shell 1.0 software, an efficient tool for progressive damage simulation in composite laminates. This guide contains minimal technical material and is meant solely as a guide for a new user to apply AF-Shell 1.0 to laminate damage simulation problems.

Can nutrient limitations explain low and declining white spruce growth near the Arctic treeline in the eastern Brooks Range, Alaska?

NASA Astrophysics Data System (ADS)

Ellison, S.; Sullivan, P. F.

2014-12-01

The position of the Arctic treeline is of critical importance for global carbon cycling and surface energy budgets. However, controls on tree growth at treeline remain uncertain. In the Alaskan Brooks Range, 20th century warming has caused varying growth responses among treeline trees, with trees in the west responding positively, while trees in the east have responded negatively. The prevailing explanation of this trend ascribes the negative growth response to warming-induced drought stress in the eastern Brooks Range. However, recent measurements of carbon isotope discrimination in tree rings, xylem sap flow and needle gas exchange suggest that drought stress cannot explain these regional growth declines. Additionally, evidence from the western Brooks Range suggests that nutrient availability, rather than drought stress, may be the proximate control on tree growth. In this study, we investigated the hypothesis that low and declining growth of eastern Brooks Range trees is due to low and declining soil nutrient availability, which may continue to decrease with climate change as soils become drier and microbial activity declines. We compared microclimate, tree performance, and a wide range of proxies for soil nutrient availability in four watersheds along a west-east transect in the Brooks Range during the growing seasons of 2013 and 2014. We hypothesized that soil nutrient availability would track closely with the strong west-east precipitation gradient, with higher rainfall and greater soil nutrient availability in the western Brooks Range. We expected to find that soil water contents in the west are near optimum for nitrogen mineralization, while those in the east are below optimum. Needle nitrogen concentration, net photosynthesis, branch extension growth, and growth in the main stem are expected to decline with the hypothesized decrease in soil nutrient availability. The results of our study will elucidate the current controls on growth of trees near the

Air Force Health Study. An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Introduction, Background and Conclusions (Chapters 1-5, 18, 19)

DTIC Science & Technology

1991-03-01

SAIC Editors: Cynthia A. Marut Ellsabeth M. Smoda SCIENCE APPLICATIONS EPIDEMIOLOGY RESEARCH DIVISION INTERNATIONAL CORPORATION ARMSTRONG LABORATORY...8400 Westpark Drive HUMAN SYSTEMS DIVISION (AFSC) McLean, VA 22102 Brooks Air Force Base, TX 78235 in con/unction WithS~DTIC SCRIPPS CLINIC & RESEARCH ...FOUNDATION, LET LA JOLLA. CA ELECTEJ•UL 011991, NATIONAL OPINION RESEARCH CENTER. CHICAGO. IL Marchl 1tO1 Introduction. Backgroend and Conclusions

Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival

PubMed Central

Fei, Dennis Liang; Motowski, Hayley; Chatrikhi, Rakesh; Gao, Shaojian; Kielkopf, Clara L.; Varmus, Harold

2016-01-01

We have asked how the common S34F mutation in the splicing factor U2AF1 regulates alternative splicing in lung cancer, and why wild-type U2AF1 is retained in cancers with this mutation. A human lung epithelial cell line was genetically modified so that U2AF1S34F is expressed from one of the two endogenous U2AF1 loci. By altering levels of mutant or wild-type U2AF1 in this cell line and by analyzing published data on human lung adenocarcinomas, we show that S34F-associated changes in alternative splicing are proportional to the ratio of S34F:wild-type gene products and not to absolute levels of either the mutant or wild-type factor. Preferential recognition of specific 3′ splice sites in S34F-expressing cells is largely explained by differential in vitro RNA-binding affinities of mutant versus wild-type U2AF1 for those same 3′ splice sites. Finally, we show that lung adenocarcinoma cell lines bearing U2AF1 mutations do not require the mutant protein for growth in vitro or in vivo. In contrast, wild-type U2AF1 is required for survival, regardless of whether cells carry the U2AF1S34F allele. Our results provide mechanistic explanations of the magnitude of splicing changes observed in U2AF1-mutant cells and why tumors harboring U2AF1 mutations always retain an expressed copy of the wild-type allele. PMID:27776121

Separated from family, students chalk up their emotions > U.S. Air Force >

Science.gov Websites

The Book Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games

New urgent care pilot program for Prime beneficiaries > U.S. Air Force >

Science.gov Websites

The Book Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games

VCSAF, spouse take in Ramstein mission sets > U.S. Air Force > Article

Science.gov Websites

The Book Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games

AF-GEOSpace Version 2.1 Release

NASA Astrophysics Data System (ADS)

Hilmer, R. V.; Ginet, G. P.; Hall, T.; Holeman, E.; Madden, D.; Perry, K. L.; Tautz, M.; Roth, C.

2006-05-01

AF-GEOSpace Version 2.1 is a graphics-intensive software program with space environment models and applications developed recently by the Space Weather Center of Excellence at AFRL. A review of new and planned AF-GEOSpace capabilities will be given. The software addresses a wide range of physical domains and addresses such topics as solar disturbance propagation, geomagnetic field and radiation belt configurations, auroral particle precipitation, and ionospheric scintillation. Building on the success of previous releases, AF-GEOSpace has become a platform for the rapid prototyping of automated operational and simulation space weather visualization products and helps with a variety of tasks, including: orbit specification for radiation hazard avoidance; satellite design assessment and post-event anomaly analysis; solar disturbance effects forecasting; determination of link outage regions for active ionospheric conditions; satellite magnetic conjugate studies, scientific model validation and comparison, physics research, and education. Previously, Version 2.0 provided a simplified graphical user interface, improved science and application modules, significantly enhanced graphical performance, common input data archive sets, and 1-D, 2-D, and 3- D visualization tools for all models. Dynamic capabilities permit multiple environments to be generated at user- specified time intervals while animation tools enable the display of satellite orbits and environment data together as a function of time. Building on the Version 2.0 software architecture, AF-GEOSpace Version 2.1 includes a host of new modules providing, for example, plasma sheet charged particle fluxes, neutral atmosphere densities, 3-D cosmic ray cutoff maps, low-altitude trapped proton belt flux specification, DMSP particle data displays, satellite magnetic field footprint mapping determination, and meteor sky maps and shower/storm fluxes with spacecraft impact probabilities. AF-GEOSpace Version 2.1 was

Isolation and cross-familial amplification of 41 microsatellites for the brook charr (Salvelinus fontinalis)

USGS Publications Warehouse

Perry, G.M.L.; King, T.L.; St. -Cyr, J.; Valcourt, M.; Bernatchez, L.

2005-01-01

The brook charr (Salvelinus fontinalis; Osteichthyes: Salmonidae) is a phenotypically diverse fish species inhabiting much of North America. But relatively few genetic diagnostic resources are available for this fish species. We isolated 41 microsatellites from S. fontinalis polymorphic in one or more species of salmonid fish. Thirty-seven were polymorphic in brook charr, 15 in the congener Arctic charr (Salvelinus alpinus) and 14 in the lake charr (Salvelinus namaycush). Polymorphism was also relatively high in Oncorhynchus, where 21 loci were polymorphic in rainbow trout (Oncorhynchus mykiss) and 16 in cutthroat trout (Oncorhynchus clarkii) but only seven and four microsatellite loci were polymorphic in the more distantly related lake whitefish (Coregonus clupeaformis) and Atlantic salmon (Salmo salar), respectively. One duplicated locus (Sfo228Lav) was polymorphic at both duplicates in S. fontinalis. ?? 2005 Blackwell Publishing Ltd.

Seismic images of the Brooks Range fold and thrust belt, Arctic Alaska, from an integrated seismic reflection/refraction experiment

USGS Publications Warehouse

Levander, A.; Fuis, G.S.; Wissinger, E.S.; Lutter, W.J.; Oldow, J.S.; Moore, Thomas E.

1994-01-01

We describe results of an integrated seismic reflection/refraction experiment across the Brooks Range and flanking geologic provinces in Arctic Alaska. The seismic acquisition was unusual in that reflection and refraction data were collected simultaneously with a 700 channel seismograph system deployed numerous times along a 315 km profile. Shot records show continuous Moho reflections from 0-180 km offset, as well as numerous upper- and mid-crustal wide-angle events. Single and low-fold near-vertical incidence common midpoint (CMP) reflection images show complex upper- and middle-crustal structure across the range from the unmetamorphosed Endicott Mountains allochthon (EMA) in the north, to the metamorphic belts in the south. Lower-crustal and Moho reflections are visible across the entire reflection profile. Travel-time inversion of PmP arrivals shows that the Moho, at 33 km depth beneath the North Slope foothills, deepens abruptly beneath the EMA to a maximum of 46 km, and then shallows southward to 35 km at the southern edge of the range. Two zones of upper- and middle-crustal reflections underlie the northern Brooks Range above ~ 12-15 km depth. The upper zone, interpreted as the base of the EMA, lies at a maximum depth of 6 km and extends over 50 km from the range front to the north central Brooks Range where the base of the EMA outcrops above the metasedimentary rocks exposed in the Doonerak window. We interpret the base of the lower zone, at ~ 12 km depth, to be from carbonate rocks above the master detachment upon which the Brooks Range formed. The seismic data suggest that the master detachment is connected to the faults in the EMA by several ramps. In the highly metamorphosed terranes south of the Doonerak window, the CMP section shows numerous south-dipping events which we interpret as a crustal scale duplex involving the Doonerak window rocks. The basal detachment reflections can be traced approximately 100 km, and dip southward from about 10-12 km

B-52 Stratofortress joins coalition team > U.S. Air Force > Article Display

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

F-15s complete Hungarian deployment > U.S. Air Force > Article Display

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Goldfein nominated as 21st CSAF > U.S. Air Force > Article Display

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

F-22 inaugural deployment to Europe > U.S. Air Force > Article Display

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Brook trout movement within a high-elevation watershed: Consequences for watershed restoration

Treesearch

Jeff L. Hansbarger; J. Todd Petty; Patricia M. Mazik

2010-01-01

We used radio-telemetry to quantify brook trout (Salvelinus fontinalis) and brown trout (Salmo trutta) movements in the Shavers Fork of the Cheat River, West Virginia, and an adjacent second-order tributary (Rocky Run). Our objectives were to quantify the overall rate of trout movement, assess spatial and temporal variation in...

NASA's Plum Brook Station Water Systems

NASA Technical Reports Server (NTRS)

Puzak, Robert M.; Kimpton, Arthur

2006-01-01

Plum Brook Station's water systems were built in the 1940s to support a World War II ordnance production complex. Because the systems had not been analyzed for current NASA usage, it was unknown if they could meet current requirements and codes or if they were efficient for current use. NASA wanted to determine what improvements would be needed or advisable to support its research projects, so it contracted a hydraulic analysis of the raw and domestic water systems. Burgess and Niple determined current water demands and water flow, developed and calibrated models of the two water systems, and evaluated efficiency improvements and cost-cutting options. They recommended replacing some water mains, installing a new service connection, and removing some high-maintenance items (an underground reservoir, some booster pumps, and a tower).

77 FR 63897 - Notice of License Terminations for National Aeronautics and Space Administration; Plum Brook...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-17

... test reactor, constructed to perform irradiation testing of fueled and unfueled experiments for space... constructed to test ``mock-up'' irradiation components for the Plum Brook Reactor. The reactors operated from...

Identification of U2AF(35)-dependent exons by RNA-Seq reveals a link between 3′ splice-site organization and activity of U2AF-related proteins

PubMed Central

Kralovicova, Jana; Knut, Marcin; Cross, Nicholas C. P.; Vorechovsky, Igor

2015-01-01

The auxiliary factor of U2 small nuclear RNA (U2AF) is a heterodimer consisting of 65- and 35-kD proteins that bind the polypyrimidine tract (PPT) and AG dinucleotides at the 3′ splice site (3′ss). The gene encoding U2AF35 (U2AF1) is alternatively spliced, giving rise to two isoforms U2AF35a and U2AF35b. Here, we knocked down U2AF35 and each isoform and characterized transcriptomes of HEK293 cells with varying U2AF35/U2AF65 and U2AF35a/b ratios. Depletion of both isoforms preferentially modified alternative RNA processing events without widespread failure to recognize 3′ss or constitutive exons. Over a third of differentially used exons were terminal, resulting largely from the use of known alternative polyadenylation (APA) sites. Intronic APA sites activated in depleted cultures were mostly proximal whereas tandem 3′UTR APA was biased toward distal sites. Exons upregulated in depleted cells were preceded by longer AG exclusion zones and PPTs than downregulated or control exons and were largely activated by PUF60 and repressed by CAPERα. The U2AF(35) repression and activation was associated with a significant interchange in the average probabilities to form single-stranded RNA in the optimal PPT and branch site locations and sequences further upstream. Although most differentially used exons were responsive to both U2AF subunits and their inclusion correlated with U2AF levels, a small number of transcripts exhibited distinct responses to U2AF35a and U2AF35b, supporting the existence of isoform-specific interactions. These results provide new insights into function of U2AF and U2AF35 in alternative RNA processing. PMID:25779042

Air Force Reserve Command

Science.gov Websites

Page Get One Now AFR Mission and Vision Statement Social Media Facebook Logo #AlwaysThere Facebook Logo Technician job vacancies on USAJobs.gov 2017 AFR Modernization Book AFR Vision and Guiding Principles 2013 AFR Vision Update 2015 Contact Air Force Reserve AFRC Public Affairs AF Reserve Recruiting Service

Air Intelligence and the Search for the Center of Gravity

DTIC Science & Technology

1988-04-01

co inAIR INTELLIGENCE AND THE 0) ~ SEARCH FOR THE CENTER OF GRAVITY F LT COL CHARLES N. CULBERTSON 1988 - .- ,------.--.- Non VL AIR UNIVERSITY RLlo...During the 1930’s the future air commanders in the Air Corps’ primary doctrinal think tank, The Air Corps Tactical School, at Maxwell Field, took this...conversation with Speer after the war General Ira Eaker, the former commander of the 6th Air Force (8 AF was the AAF’s primary strategic striking arm in

A Study to Evaluate the Organization and the Operating Procedures of the Patient Assistance Function at Brooke Army Medical Center, Fort Sam Houston, Texas

DTIC Science & Technology

1979-08-01

15 March 1979. 59Interview with Wendy L. Farace , Head Nurse, Obstetrics/Gynecology Clinic, Brooke Army Medical Center, Fort Sam Houston, Texas, 8...6 February 1979. Farace , Wendy L. Head Nurse, Obstetrica/Gynecology Clinic, Brooke Army Medical Center, Fort Sam Houston, Texas. Interview, 8 January

Is AF Ablation Cost Effective?

PubMed Central

Martin-Doyle, William; Reynolds, Matthew R.

2010-01-01

The use of catheter ablation to treat AF is increasing rapidly, but there is presently an incomplete understanding of its cost-effectiveness. AF ablation procedures involve significant up-front expenditures, but multiple randomized trials have demonstrated that ablation is more effective than antiarrhythmic drugs at maintaining sinus rhythm in a second-line and possibly first-line rhythm control setting. Although truly long-term data are limited, ablation, as compared with antiarrrhythmic drugs, also appears associated with improved symptoms and quality of life and a reduction in downstream hospitalization and other health care resource utilization. Several groups have developed cost effectiveness models comparing AF ablation primarily to antiarrhythmic drugs and the model results suggest that ablation likely falls within the range generally accepted as cost-effective in developed nations. This paper will review available information on the cost-effectiveness of catheter ablation for the treatment of atrial fibrillation, and discuss continued areas of uncertainty where further research is required. PMID:20936083

Preliminary plan for testing a thermionic reactor in the Plum Brook Space Power Facility

NASA Technical Reports Server (NTRS)

Haley, F. A.

1972-01-01

A preliminary plan is presented for testing a thermionic reactor in the Plum Brook Space Power Facility (SPF). A technical approach, cost estimate, manpower estimate, and schedule are presented to cover a 2 year full power reactor test.

KC-46 team wins DOD environmental award > U.S. Air Force > Article Display

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Air Force Chaplains' Perceived Effectiveness on Service Member's Resilience and Satisfaction.

PubMed

Cafferky, Bryan; Norton, Aaron; Travis, Wendy J

2017-01-01

This study examined how 3,777 active duty male United States Air Force service members' (SMs) rank and residence location moderated the associations between perceived chaplain effectiveness, SMs' resilience, family coping, marital satisfaction, and satisfaction with the Air Force (AF). A multiple-sample structural equation model was conducted with four subgroups of SMs who had received chaplain support: enlisted members living on base, enlisted members living off base, officers living on base, and officers living off base. Chaplain effectiveness was significantly related, both directly and indirectly, to SM's spirituality, resilience, family coping, marital satisfaction, and AF satisfaction. Resilience was significantly associated with increased AF satisfaction for all SMs, except for those living on base. However, living on base was found to strengthen the protective factor between family coping and relationship satisfaction. Rank was found to moderate the link between resilience and family coping. Family coping was significantly related to increased relationship satisfaction.

Geochemical evidence for a brooks range mineral belt, Alaska

USGS Publications Warehouse

Marsh, S.P.; Cathrall, J.B.

1981-01-01

Geochemical studies in the central Brooks Range, Alaska, delineate a regional, structurally controlled mineral belt in east-west-trending metamorphic rocks and adjacent metasedimentary rocks. The mineral belt extends eastward from the Ambler River quadrangle to the Chandalar and Philip Smith quadrangles, Alaska, from 147?? to 156??W. longitude, a distance of more than 375 km, and spans a width from 67?? to 69??N. latitude, a distance of more than 222 km. Within this belt are several occurrences of copper and molybdenum mineralization associated with meta-igneous, metasedimentary, and metavolcanic rocks; the geochemical study delineates target areas for additional occurrences. A total of 4677 stream-sediment and 2286 panned-concentrate samples were collected in the central Brooks Range, Alaska, from 1975 to 1979. The -80 mesh ( 2.86) nonmagnetic fraction of the panned concentrates from stream sediment were analyzed by semiquantitative spectrographic methods. Two geochemical suites were recognized in this investigation; a base-metal suite of copper-lead-zinc and a molybdenum suite of molybdenum-tin-tungsten. These suites suggest several types of mineralization within the metamorphic belt. Anomalies in molybdenum with associated Cu and W suggest a potential porphyry molybdenum system associated with meta-igneous rocks. This regional study indicates that areas of metaigneous rocks in the central metamorphic belt are target areas for potential mineralized porphyry systems and that areas of metavolcanic rocks are target areas for potential massive sulfide mineralization. ?? 1981.

Safety of percutaneous left atrial appendage closure: results from the Watchman Left Atrial Appendage System for Embolic Protection in Patients with AF (PROTECT AF) clinical trial and the Continued Access Registry.

PubMed

Reddy, Vivek Y; Holmes, David; Doshi, Shephal K; Neuzil, Petr; Kar, Saibal

2011-02-01

The Watchman Left Atrial Appendage System for Embolic Protection in Patients With AF (PROTECT AF) randomized trial compared left atrial appendage closure against warfarin in atrial fibrillation (AF) patients with CHADS₂ ≥1. Although the study met the primary efficacy end point of being noninferior to warfarin therapy for the prevention of stroke/systemic embolism/cardiovascular death, there was a significantly higher risk of complications, predominantly pericardial effusion and procedural stroke related to air embolism. Here, we report the influence of experience on the safety of percutaneous left atrial appendage closure. The study cohort for this analysis included patients in the PROTECT AF trial who underwent attempted device left atrial appendage closure (n=542 patients) and those from a subsequent nonrandomized registry of patients undergoing Watchman implantation (Continued Access Protocol [CAP] Registry; n=460 patients). The safety end point included bleeding- and procedure-related events (pericardial effusion, stroke, device embolization). There was a significant decline in the rate of procedure- or device-related safety events within 7 days of the procedure across the 2 studies, with 7.7% and 3.7% of patients, respectively, experiencing events (P=0.007), and between the first and second halves of PROTECT AF and CAP, with 10.0%, 5.5%, and 3.7% of patients, respectively, experiencing events (P=0.006). The rate of serious pericardial effusion within 7 days of implantation, which had made up >50% of the safety events in PROTECT AF, was lower in the CAP Registry (5.0% versus 2.2%, respectively; P=0.019). There was a similar experience-related improvement in procedure-related stroke (0.9% versus 0%, respectively; P=0.039). Finally, the functional impact of these safety events, as defined by significant disability or death, was statistically superior in the Watchman group compared with the warfarin group in PROTECT AF. This remained true whether significance

Analysis of nitrogen dynamics in the Lye Brook Wilderness Area, Vermont, USA

Treesearch

John L. Campbell; Christopher Eagar; William H. McDowell; James W. Hornbeck

2000-01-01

Nitrogen (N) deposition and its impact on terrestrial and aquatic ecosystems is a concern facing federal land managers at the Lye Brook Wilderness in Vermont and other protected areas throughout the northeastern United States. In this study, we compared N production in soils with N concentrations and outputs in leachates to determine how forest cover types differ in...

Past and future effects of atmospheric deposition on the forest ecosystem at the Hubbard Brook Experimental Forest: simulations with the dynamic model ForSAFE

Treesearch

Salim Belyazid; Scott Bailey; Harald Sverdrup

2010-01-01

The Hubbard Brook Ecosystem Study presents a unique opportunity for studying long-term ecosystem responses to changes in anthropogenic factors. Following industrialisation and the intensification of agriculture, the Hubbard Brook Experimental Forest (HBEF) has been subject to increased loads of atmospheric deposition, particularly sulfur and nitrogen. The deposition of...

[Obituary] In memoriam: Mortimer Brooke Meanley, Jr., 1915-2007

USGS Publications Warehouse

Perry, Matthew C.

2008-01-01

Mortimer Brooke Meanley, Jr., was born at Riderwood, Baltimore County, Maryland, on 19 January 1915, and died at home in Maine on 19 August 2007. He was always called “Brooke” as an adult. Much of his youth was spent in birding and other natural-history activities, interest he credits to the Boy Scouts and his teachers. These activities directed him toward a professional career in wildlife biology. He was educated at McDonogh High School in Owings Mill, Maryland – at the time a private, semimilitary school for boys – and graduated in 1934.

75 FR 38716 - Safety Zone; Vietnam Veterans of America Fireworks Display, Brookings, OR

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-06

...-AA00 Safety Zone; Vietnam Veterans of America Fireworks Display, Brookings, OR AGENCY: Coast Guard, DHS... waters of Pelican Bay and the Pacific Ocean for the Vietnam Veterans of America Fireworks Display near... period will have passed. Basis and Purpose The Vietnam Veterans of America are holding a fireworks...

75 FR 426 - Notice of Application for Disclaimer of Interest, Brookings County, SD

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-05

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLMT924000-L54200000-FR0000-LVDIE09E0470; SDM 99176] Notice of Application for Disclaimer of Interest, Brookings County, SD AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: An application has been filed with the Bureau of...

Deformation and the timing of gas generation and migration in the eastern Brooks Range foothills, Arctic National Wildlife Refuge, Alaska

USGS Publications Warehouse

Parris, T.M.; Burruss, R.C.; O'Sullivan, P. B.

2003-01-01

Along the southeast border of the 1002 Assessment Area in the Arctic National Wildlife Refuge, Alaska, an explicit link between gas generation and deformation in the Brooks Range fold and thrust belt is provided through petrographic, fluid inclusion, and stable isotope analyses of fracture cements integrated with zircon fission-track data. Predominantly quartz-cemented fractures, collected from thrusted Triassic and Jurassic rocks, contain crack-seal textures, healed microcracks, and curved crystals and fluid inclusion populations, which suggest that cement growth occurred before, during, and after deformation. Fluid inclusion homogenization temperatures (175-250??C) and temperature trends in fracture samples suggest that cements grew at 7-10 km depth during the transition from burial to uplift and during early uplift. CH4-rich (dry gas) inclusions in the Shublik Formation and Kingak Shale are consistent with inclusion entrapment at high thermal maturity for these source rocks. Pressure modeling of these CH4-rich inclusions suggests that pore fluids were overpressured during fracture cementation. Zircon fission-track data in the area record postdeposition denudation associated with early Brooks Range deformation at 64 ?? 3 Ma. With a closure temperature of 225-240??C, the zircon fission-track data overlap homogenization temperatures of coeval aqueous inclusions and inclusions containing dry gas in Kingak and Shublik fracture cements. This critical time-temperature relationship suggests that fracture cementation occurred during early Brooks Range deformation. Dry gas inclusions suggest that Shublik and Kingak source rocks had exceeded peak oil and gas generation temperatures at the time structural traps formed during early Brooks Range deformation. The timing of hydrocarbon generation with respect to deformation therefore represents an important exploration risk for gas exploration in this part of the Brooks Range fold and thrust belt. The persistence of gas high at

AF-GEOSPACE Version 2.1

NASA Astrophysics Data System (ADS)

Hilmer, R. V.; Ginet, G. P.; Hall, T.; Holeman, E.; Madden, D.; Tautz, M.; Roth, C.

2004-05-01

AF-GEOSpace is a graphics-intensive software program with space environment models and applications developed and distributed by the Space Weather Center of Excellence at AFRL. A review of current (Version 2.0) and planned (Version 2.1) AF-GEOSpace capabilities will be given. A wide range of physical domains is represented enabling the software to address such things as solar disturbance propagation, radiation belt configuration, and ionospheric auroral particle precipitation and scintillation. The software is currently being used to aid with the design, operation, and simulation of a wide variety of communications, navigation, and surveillance systems. Building on the success of previous releases, AF-GEOSpace has become a platform for the rapid prototyping of automated operational and simulation space weather visualization products and helps with a variety of tasks, including: orbit specification for radiation hazard avoidance; satellite design assessment and post-event anomaly analysis; solar disturbance effects forecasting; frequency and antenna management for radar and HF communications; determination of link outage regions for active ionospheric conditions; scientific model validation and comparison, physics research, and education. Version 2.0 provided a simplified graphical user interface, improved science and application modules, and significantly enhanced graphical performance. Common input data archive sets, application modules, and 1-D, 2-D, and 3-D visualization tools are provided to all models. Dynamic capabilities permit multiple environments to be generated at user-specified time intervals while animation tools enable displays such as satellite orbits and environment data together as a function of time. Building on the existing Version 2.0 software architecture, AF-GEOSpace Version 2.1 is currently under development and will include a host of new modules to provide, for example, geosynchronous charged particle fluxes, neutral atmosphere densities

National Program for Inspection of Non-Federal Dams. Pattaconk Reservoir Dam (CT 00398), Connecticut River Basin, Chester, Connecticut. Phase I inspection Report

DTIC Science & Technology

1979-03-01

approximately 824 acre-feet of water with the reservoir level at the top of the dam, which is approximately 23 feet above the bed of Pattaconk Brook. According...Pattaconk Brook, from 2 to 4 feet above the water level. Should the dam breach, there is potential for loss of life at this downstream development. e...under the jurisdiction of the Water Resources Commission as af State Park in 1959. f. Operator - None. g. Purpose of the Dam - Recreational; Part of

Fairchild takes in evacuated McConnell KC-135s > U.S. Air Force > Article

Science.gov Websites

The Book Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games

Genetic identity of brook trout in Lake Superior south shore streams: Potential for genetic monitoring of stocking and rehabilitation efforts

USGS Publications Warehouse

Sloss, Brian L.; Jennings, Martin J.; Franckowiak, R.; Pratt, D.M.

2008-01-01

Rehabilitation of migratory ('coaster') brook trout Salvelinus fontinalis along Lake Superior's south shore is a topic of high interest among resource stakeholders and management agencies. Proposed strategies for rehabilitation of this brook trout life history variant in Wisconsin include supplemental stocking, watershed management, habitat rehabilitation, harvest regulations, or a combination thereof. In an effort to evaluate the success of coaster brook trout rehabilitation efforts, we collected genetic data from four populations of interest (Whittlesey Creek, Bois Brule River, Bark River, and Graveyard Creek) and the hatchery sources used in the Whittlesey Creek supplementation experiment. We characterized the genetic diversity of 30 individuals from each of four populations using 13 microsatellite DNA loci. Levels of genetic variation were consistent with those in similar studies conducted throughout the basin. Significant genetic variation among the populations was observed, enabling adequate population delineation through assignment tests. Overall, 208 of the 211 sampled fish (98.6%) were correctly assigned to their population of origin. Simulated F1 hybrids between two hatchery strains and the Whittlesey Creek population were identifiable in the majority of attempts (90.5-100% accuracy with 0-2.5% error). The genetic markers and analytical techniques described provide the ability to monitor the concurrent coaster brook trout rehabilitation efforts along Wisconsin's Lake Superior south shore, including the detection of hybridization between hatchery and native populations. ?? Copyright by the American Fisheries Society 2008.

EXPERIMENTAL ACIDIFICATION CAUSES SOIL BASE-CATION DEPLETION AT THE BEAR BROOK WATERSHED IN MAINE

EPA Science Inventory

There is concern that changes in atmospheric deposition, climate, or land use have altered the biogeochemistry of forests causing soil base-cation depletion, particularly Ca. The Bear Brook Watershed in Maine (BBWM) is a paired watershed experiment with one watershed subjected to...

Management of atrial fibrillation in Greece: the MANAGE-AF study.

PubMed

Andrikopoulos, George; Pastromas, Sokratis; Mantas, Ioannis; Sakellariou, Dimitris; Kyrpizidis, Christos; Makridis, Pantelis; Goumas, Georgios; Stakos, Dimitris; Gotsis, Alexandros; Kartalis, Athanasios; Kazianis, Georgios; Babalis, Dimitrios; Toli, Konstantina; Tzeis, Stylianos; Papavasileiou, Maria; Kalogeropoulos, Petros; Vardas, Panos

2014-01-01

Although atrial fibrillation (AF) is a highly prevalent health problem with high morbidity and mortality, data regarding the clinical characteristics and management of AF in the Greek population are scarce. The "Current Clinical Practice in the MANAGEment of Atrial Fibrillation in Greece" study (MANAGEAF) aimed to assess the epidemiological features as well as the daily clinical practice in the management of Greek patients with AF. Taking into consideration the distribution of the Greek population, 603 consecutive patients over 18 years of age, with any type of AF, presenting at the emergency departments or outpatient clinics of 27 different centers, were included in our study. The mean age of the patients was 68.5 ± 12.1 years, with male patients representing 52.5% of the study population. The most common AF type in our cohort was non-paroxysmal AF (60%), including the patients with permanent (24.1%), persistent (17.4%), long-standing (4.8%) and first diagnosed AF (13.8%). Hypertension was the most common comorbidity (70.3%). A history of stroke or transient ischemic attack was detected in 9.2% of the patients, while 6.2% had a history of gastrointestinal bleeding. About half of the patients (49.3%) were treated with anticoagulant drugs, mainly vitamin K antagonists (46.9%), while 34.2% were on antiplatelet drugs, aspirin and/or clopidogrel. The mean INR level (1.7 ± 0.8) was sub-therapeutic, although the mean values for CHADS2 and CHA2DS2-VASc scores were 1.6 ± 1.2 and 3.0 ± 1.7, respectively. The MANAGE-AF baseline results indicate unsatisfactory levels of compliance with the current guidelines for the management of AF in Greece. Considering the undisputed effectiveness of anticoagulant treatment for preventing AF-related strokes, MANAGE-AF demonstrates the need for optimization of our therapeutic strategies for the management of cardioembolic stroke risk.

Clark AFB, Philippines. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1984-02-01

DATA PROCESSING DIVISION USAFETAC Air Weather Service ( MAC) 2L._qi( .3 I-H M3,; #983270 :.15 11 E 120 33 EL --V478 FT ?.p1K I-ARTS A-F HUMS...THIS PAGE .a.. E ...d) REPORT DOCUMENTATION PAGE READ INSTRUCTIONS REPORTDOCUMENTATIONPAGE_ BEFORE COMPLETING FORM I REPORT NUMBER 12 GOVT ACCESSION NO. 3...62225 P. 320 14 MONITORING AGENCY NAME & ADDRESS(f dlle’. e , Ifr Controlling Offfe) 15. SECURITY CLASS. (of this report) UNCLASSIFIED T5

Installation Restoration Program. Phase 2. Confirmation/Quantification. Stage 1. Problem Confirmation Study: Otis Air National Guard Base, Massachusetts, Air National Guard Support Center, Andrews Air Force Base, Maryland.

DTIC Science & Technology

1985-09-04

health effects was noted in any of the monitor wells. Wells RFW- I , RFW-2A, . and RFW-4, at the Base Landfill, RFW-5 (CFTA) and RFW-10 (PFSA) were...88-D-4006 F/G 24/4 UmEohEEEEEEmiE EEEEEAhEEEEEEEEEEEEEEEEEE EhEEEEmmhmmhhEEE I EEEEEEEEEEEEE 11111 3315 111W12 w ~ ~ ~ ~ d -W w w - v w v w ,!:..4 4...OEHL) Brooks Air Force Ba:;e, Texas 78235-5501• DTIC ECTE October 1935 JUL 0 6 1988 H p.’ DESI CONSULTANTS Approve-. h)r pvhTElMre Volume I - Text " L

Enhancing Inquiry, Evidence-Based Reflection, and Integrative Learning with the Lifelong ePortfolio Process: The Implementation of Integrative ePortfolios at Stony Brook University

ERIC Educational Resources Information Center

Wozniak, Nancy McCoy

2013-01-01

Reflection plays a critical role in moving learning to the next level of inquiry. Stony Brook University has adopted an approach to using ePortfolios within the curriculum that emphasizes reflection. Stony Brook University successfully piloted ePortfolios in the Fall 2010 Semester and discovered their use facilitated the inquiry process for the…

Drivers and evolution of episodic acidification at the Bear Brook Watershed in Maine, USA.

PubMed

Laudon, Hjalmar; Norton, Stephen A

2010-12-01

Despite decades of research about episodic acidification in many regions of the world, the understanding of what controls the transient changes in stream water chemistry occurring during rain and snow melt events is still limited. Here, we use 20 years of hydrological and stream chemical data from the paired watershed study at Bear Brook Watershed in Maine (BBWM), USA to improve the understanding of the effects of acid deposition on the causes, drivers, and evolution of episodic acidification. The long-term experimental study at BBWM includes 18 years of chemical treatment of the West Bear Brook (WB) watershed with (NH(4))(2)SO(4). East Bear Brook (EB) serves as reference. The treatment started in 1989 following a 2-year pretreatment period. We analyzed 212 hydrological episodes using an episode model that can separate and quantify individual drivers of the transient change in acid-neutralizing capacity (ANC) during hydrological events. The results suggest that 18 years of N and S addition have not affected the natural drivers of episodic acidification of base-cation dilution, marine sea salt episodes, or organic acidity during rain and snow melt events. The contribution of SO4(2-) to the ANC decline in WB has been increasing linearly since the beginning of watershed treatment, while the role of NO3- has remained relatively constant after an initial increase. This is contradictory to many previous shorter-term studies and illustrates the need for a more mechanistic understanding of the causes and drivers of episodic acidification during rain- and snow melt-driven hydrological events.

Density-Dependent Regulation of Brook Trout Population Dynamics along a Core-Periphery Distribution Gradient in a Central Appalachian Watershed

PubMed Central

Huntsman, Brock M.; Petty, J. Todd

2014-01-01

Spatial population models predict strong density-dependence and relatively stable population dynamics near the core of a species' distribution with increasing variance and importance of density-independent processes operating towards the population periphery. Using a 10-year data set and an information-theoretic approach, we tested a series of candidate models considering density-dependent and density-independent controls on brook trout population dynamics across a core-periphery distribution gradient within a central Appalachian watershed. We sampled seven sub-populations with study sites ranging in drainage area from 1.3–60 km2 and long-term average densities ranging from 0.335–0.006 trout/m. Modeled response variables included per capita population growth rate of young-of-the-year, adult, and total brook trout. We also quantified a stock-recruitment relationship for the headwater population and coefficients of variability in mean trout density for all sub-populations over time. Density-dependent regulation was prevalent throughout the study area regardless of stream size. However, density-independent temperature models carried substantial weight and likely reflect the effect of year-to-year variability in water temperature on trout dispersal between cold tributaries and warm main stems. Estimated adult carrying capacities decreased exponentially with increasing stream size from 0.24 trout/m in headwaters to 0.005 trout/m in the main stem. Finally, temporal variance in brook trout population size was lowest in the high-density headwater population, tended to peak in mid-sized streams and declined slightly in the largest streams with the lowest densities. Our results provide support for the hypothesis that local density-dependent processes have a strong control on brook trout dynamics across the entire distribution gradient. However, the mechanisms of regulation likely shift from competition for limited food and space in headwater streams to competition for

Field performance of timber bridges. 10, Sanborn Brook stress-laminated deck bridge

Treesearch

P. D. Hilbrich Lee; J. P. Wacker; M. A. Ritter

The Sanborn Brook bridge was constructed in August 1991, 10 miles northeast of Concord, New Hampshire, as part of the demonstration timber bridge program of the USDA Forest Service. The bridge is a simple-span, double-lane, stress-laminated deck superstructure constructed from Southern Pine lumber and is approximately 25 ft long and 28 ft wide with a skew of 14 degrees...

F-22 Raptors fly into Lithuania as part of European tour > U.S. Air Force >

Science.gov Websites

The Book Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games

Absenteeism Among Air Force Active Duty and Civilian Personnel.

DTIC Science & Technology

1985-09-01

Fitzgibbons, Dale and Michael Moch. "Employee Absenteeism : A Multivariate Analysis with Replication," Organizational Behavior and Human Performance ...AD-A161 073 ABSENTEEISM AMONG AIR FORCE ACTIVE DUTY AND CIVILIAN PERSONNEL(U) AIR FORCE INST OF TECH IRIGHT-PRTTERSON AFB OH SCHOOL OF SYSTEMS AND...8217o 7 ABSENTEEISM AMONG AIR FORCE ACTIUE DUTY AND CIUILIAN PERSONNEL THESIS William M. Getter Captain, USAF AF IT/GLM/LSB/5S-27 DT|C ELECTE SNOVI 2Q8 v

Habitat suitability index model for brook trout in streams of the Southern Blue Ridge Province: Surrogate variables, model evaluation, and suggested improvements

USGS Publications Warehouse

Schmitt, C.J.; Lemly, A.D.; Winger, P.V.

1993-01-01

Data from several sources were collated and analyzed by correlation, regression, and principal components analysis to define surrrogate variables for use in the brook trout (Salvelinus fontinalis) habitat suitability index (HSI) model, and to evaluate the applicability of the model for assessing habitat in high elevation streams of the southern Blue Ridge Province (SBRP). In all data sets examined, pH and alkalinity were highly correlated, and both declined with increasing elevation; however, the magnitude of the decline varied with underlying rock formations and other factors, thereby restricting the utility of elevation as a surrogate for pH. In the data sets that contained biological information, brook trout abundance (as biomass, density, or both) tended to increase with elevation and decrease with the abundance of rainbow trout (Oncorhynchus mykiss), and was not significantly correlated (P >0.05) with the abundance of most benthic macroinvertebrate taxa normally construed as important in the diet of brook trout. Using multiple linear regression, the authors formulated an alternative HSI model A? based on point estimates of gradient, pH, elevation, stream width, and rainbow trout density A? which explained 40 to 50 percent of the variance in brook trout density in 256 stream reaches. Although logically developed, the present U.S. Fish and Wildlife Service HSI model, proposed in 1982, seems deficient in several areas, especially when applied to SBRP streams. The authors recommend that the water quality component in the model be updated and reevaluated, focusing on the differential sensitivities of each life stage, the stochastic nature of the water quality variables, and the possible existence of habitat requirements that differ among brook trout strains.

Corrective Lens Use and Refractive Error Among United States Air Force Aircrew

DTIC Science & Technology

2010-03-01

surgery was approved for aircrew members in August 2000. Initially only photorefractive keratectomy ( PRK ) was approved, but 200 MILITARY MEDICINE, Vol...approval for laser in-situ keratomileusis ( LASIK ), although USAF policy limits CRS treatments on aircrew to no more than 8.00 D of myopia, no more than...Undergraduate Pilot Training Pass/Fail Rate of Spectacled vs . Nonspectacled Student Pilots. Report No. USAFSAM-TR-85-50. Brooks Air Eorce Base, TX, USAE

Supporting Air and Space Expeditionary Forces: Analysis of Combat Support Basing Options

DTIC Science & Technology

2004-01-01

Brooke et al., 2003. 13 For more information on Set Covering models, see Daskin , 1995. Analysis Methodology 43 Transportation Model. A detailed...This PDF document was made available from www.rand.org as a public service of the RAND Corporation. 6Jump down to document Visit RAND at...www.rand.org Explore RAND Project AIR FORCE View document details This document and trademark(s) contained herein are protected by law as indicated in a

Left atrial structure and function in atrial fibrillation: ENGAGE AF-TIMI 48

PubMed Central

Gupta, Deepak K.; Shah, Amil M.; Giugliano, Robert P.; Ruff, Christian T.; Antman, Elliott M.; Grip, Laura T.; Deenadayalu, Naveen; Hoffman, Elaine; Patel, Indravadan; Shi, Minggao; Mercuri, Michele; Mitrovic, Veselin; Braunwald, Eugene; Solomon, Scott D.

2014-01-01

Aims The complex relationship between left atrial (LA) structure and function, electrical burden of atrial fibrillation (AF) and stroke risk is not well understood. We aimed to describe LA structure and function in AF. Methods and results Left atrial structure and function was assessed in 971 subjects enrolled in the echocardiographic substudy of ENGAGE AF-TIMI 48. Left atrial size, emptying fraction (LAEF), and contractile function were compared across AF types (paroxysmal, persistent, or permanent) and CHADS2 scores as an estimate of stroke risk. The majority of AF patients (55%) had both LA enlargement and reduced LAEF, with an inverse relationship between LA size and LAEF (R = −0.57, P < 0.001). With an increasing electrical burden of AF and higher CHADS2 scores, LA size increased and LAEF declined. Moreover, 19% of AF subjects had impaired LAEF despite normal LA size, and LA contractile dysfunction was present even among the subset of AF subjects in sinus rhythm at the time of echocardiography. Conclusions In a contemporary AF population, LA structure and function were increasingly abnormal with a greater electrical burden of AF and higher stroke risk estimated by the CHADS2 score. Moreover, LA dysfunction was present despite normal LA size and sinus rhythm, suggesting that the assessment of LA function may add important incremental information in the evaluation of AF patients. Clinical Trial Registration: http://www.clinicaltrials.gov; ID = NCT00781391. PMID:24302269

IMPACTS OF MARINE AEROSOLS ON SURFACE WATER CHEMISTRY AT BEAR BROOK WATERSHED, MAINE USA

EPA Science Inventory

The East Bear catchment at Bear Brook Watershed, Maine receives moderate (for the eastern U.S.) amounts of Cl- in wet and dry deposition. In 1989, Cl- in precipitation ranged from 2 to 55 eq/L. Dry, occult, and wet deposition plus evapotranspiration resulted in stream Cl- averagi...

Comparisons with results from the Hubbard Brook Experimental Forest in the Northern Appalachians

Treesearch

James Hornbeck; Amey S. Bailey; Christopher Eagar; John L. Campbell

2014-01-01

The Hubbard Brook Experimental Forest (HBEF) is located in central New Hampshire, in the heart of the White Mountains, toward the northern end of the Appalachian chain. HBEF was established in 1955, two decades after Coweeta Hydrologic Laboratory (CHL), but research objectives at both sites have long been similar, that is, to understand hydrologic and nutrient cycling...

A useful single-solution polychrome stain for plant material...Brook Cyte-Chrome I.

Treesearch

Stanley L Krugman; Julia F. Littlefield

1968-01-01

Fresh and chemically fixed sectioned plant material can be quickly stained by applying a Brook Cyte Chrome I polychrome stain. Staining time averaged only about 10 minutes. And exact timing of staining and de-staining is not as critical as with most of the commonly used stains. The overall quality is comparable to that of the traditional stains.

Structure and biological activities of eumenine mastoparan-AF (EMP-AF), a new mast cell degranulating peptide in the venom of the solitary wasp (Anterhynchium flavomarginatum micado).

PubMed

Konno, K; Hisada, M; Naoki, H; Itagaki, Y; Kawai, N; Miwa, A; Yasuhara, T; Morimoto, Y; Nakata, Y

2000-11-01

A new mast cell degranulating peptide, eumenine mastoparan-AF (EMP-AF), was isolated from the venom of the solitary wasp Anterhynchium flavomarginatum micado, the most common eumenine wasp found in Japan. The structure was analyzed by FAB-MS/MS together with Edman degradation, which was corroborated by solid-phase synthesis. The sequence of EMP-AF, Ile-Asn-Leu-Leu-Lys-Ile-Ala-Lys-Gly-Ile-Ile-Lys-Ser-Leu-NH(2), was similar to that of mastoparan, a mast cell degranulating peptide from a hornet venom; tetradecapeptide with C-terminus amidated and rich in hydrophobic and basic amino acids. In fact, EMP-AF exhibited similar activity to mastoparan in stimulating degranulation from rat peritoneal mast cells and RBL-2H3 cells. It also showed significant hemolytic activity in human erythrocytes. Therefore, this is the first example that a mast cell degranulating peptide is found in the solitary wasp venom. Besides the degranulation and hemolytic activity, EMP-AF also affects on neuromuscular transmission in the lobster walking leg preparation. Three analogs EMP-AF-1 approximately 3 were snythesized and biologically tested together with EMP-AF, resulting in the importance of the C-terminal amide structure for biological activities.

New orbit recalculations of comet C/1890 F1 Brooks and its dynamical evolution

NASA Astrophysics Data System (ADS)

Królikowska, Małgorzata; Dybczyński, Piotr A.

2016-08-01

C/1890 F1 Brooks belongs to a group of 19 comets used by Jan Oort to support his famous hypothesis on the existence of a spherical cloud containing hundreds of billions of comets with orbits of semi-major axes between 50 000 and 150 000 au. Comet Brooks stands out from this group because of a long series of astrometric observations as well as a nearly 2-yr-long observational arc. Rich observational material makes this comet an ideal target for testing the rationality of an effort to recalculate astrometric positions on the basis of original (comet-star) measurements using modern star catalogues. This paper presents the results of such a new analysis based on two different methods: (I) automatic re-reduction based on cometary positions and the (comet-star) measurements and (II) partially automatic re-reduction based on the contemporary data for the reference stars originally used. We show that both methods offer a significant reduction in the uncertainty of orbital elements. Based on the most preferred orbital solution, the dynamical evolution of comet Brooks during three consecutive perihelion passages is discussed. We conclude that C/1890 F1 is a dynamically old comet that passed the Sun at a distance below 5 au during its previous perihelion passage. Furthermore, its next perihelion passage will be a little closer than during the 1890-1892 apparition. C/1890 F1 is interesting also because it suffered extremely small planetary perturbations when it travelled through the planetary zone. Therefore, in the next passage through perihelion, it will once again be a comet from the Oort spike.

Spatial heterogeneity of mobilization processes and input pathways of herbicides into a brook in a small agricultural catchment

NASA Astrophysics Data System (ADS)

Doppler, Tobias; Lück, Alfred; Popow, Gabriel; Strahm, Ivo; Winiger, Luca; Gaj, Marcel; Singer, Heinz; Stamm, Christian

2010-05-01

Soil applied herbicides can be transported from their point of application (agricultural field) to surface waters during rain events. There they can have harmful effects on aquatic species. Since the spatial distribution of mobilization and transport processes is very heterogeneous, the contributions of different fields to the total load in a surface water body may differ considerably. The localization of especially critical areas (contributing areas) can help to efficiently minimize herbicide inputs to surface waters. An agricultural field becomes a contributing area when three conditions are met: 1) herbicides are applied, 2) herbicides are mobilized on the field and 3) the mobilized herbicides are transported rapidly to the surface water. In spring 2009, a controlled herbicide application was performed on corn fields in a small (ca 1 km2) catchment with intensive crop production in the Swiss plateau. Subsequently water samples were taken at different locations in the catchment with a high temporal resolution during rain events. We observed both saturation excess and hortonian overland flow during the field campaign. Both can be important mobilization processes depending on the intensity and quantity of the rain. This can lead to different contributing areas during different types of rain events. We will show data on the spatial distribution of herbicide loads during different types of rain events. Also the connectivity of the fields with the brook is spatially heterogeneous. Most of the fields are disconnected from the brook by internal sinks in the catchment, which prevents surface runoff from entering the brook directly. Surface runoff from these disconnected areas can only enter the brook rapidly via macropore-flow into tile drains beneath the internal sinks or via direct shortcuts to the drainage system (maintenance manholes, farmyard or road drains). We will show spatially distributed data on herbicide concentration in purely subsurface systems which shows

Crustal implications of bedrock geology along the Trans-Alaska Crustal Transect (TACT) in the Brooks Range, northern Alaska

USGS Publications Warehouse

Moore, Thomas E.; Wallace, W.K.; Mull, C.G.; Adams, K.E.; Plafker, G.; Nokleberg, W.J.

1997-01-01

Geologic mapping of the Trans-Alaska Crustal Transect (TACT) project along the Dalton Highway in northern Alaska indicates that the Endicott Mountains allochthon and the Hammond terrane compose a combined allochthon that was thrust northward at least 90 km in the Early Cretaceous. The basal thrust of the combined allochthon climbs up section in the hanging wall from a ductile shear zone, in the south through lower Paleozoic rocks of the Hammond terrane and into Upper Devonian rocks of the Endicott Mountains allochthon at the Mount Doonerak antiform, culminating in Early Cretaceous shale in the northern foothills of the Brooks Range. Footwall rocks north of the Mount Doonerak antiform are everywhere parautochthonous Permian and Triassic shale of the North Slope terrane rather than Jurassic and Lower Cretaceous strata of the Colville Basin as shown in most other tectonic models of the central Brooks Range. Stratigraphic and structural relations suggest that this thrust was the basal detachment for Early Cretaceous deformation. Younger structures, such as the Tertiary Mount Doonerak antiform, deform the Early Cretaceous structures and are cored by thrusts that root at a depth of about 10 to 30 km along a deeper detachment than the Early Cretaceous detachment. The Brooks Range, therefore, exposes (1) an Early Cretaceous thin-skinned deformational belt developed during arc-continent collision and (2) a mainly Tertiary thick-skinned orogen that is probably the northward continuation of the Rocky Mountains erogenic belt. A down-to-the-south zone of both ductile and brittle normal faulting along the southern margin of the Brooks Range probably formed in the mid-Cretaceous by extensional exhumation of the Early Cretaceous contractional deformation. copyright. Published in 1997 by the American Geophysical Union.

Increased Heart Rate Is Associated With Higher Mortality in Patients With Atrial Fibrillation (AF): Results From the Outcomes Registry for Better Informed Treatment of AF (ORBIT-AF)

PubMed Central

Steinberg, Benjamin A; Kim, Sunghee; Thomas, Laine; Fonarow, Gregg C; Gersh, Bernard J; Holmqvist, Fredrik; Hylek, Elaine; Kowey, Peter R; Mahaffey, Kenneth W; Naccarelli, Gerald; Reiffel, James A; Chang, Paul; Peterson, Eric D; Piccini, Jonathan P

2015-01-01

Background Most patients with atrial fibrillation (AF) require rate control; however, the optimal target heart rate remains under debate. We aimed to assess rate control and subsequent outcomes among patients with permanent AF. Methods and Results We studied 2812 US outpatients with permanent AF in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation. Resting heart rate was measured longitudinally and used as a time-dependent covariate in multivariable Cox models of all-cause and cause-specific mortality during a median follow-up of 24 months. At baseline, 7.4% (n=207) had resting heart rate <60 beats per minute (bpm), 62% (n=1755) 60 to 79 bpm, 29% (n=817) 80 to 109 bpm, and 1.2% (n=33) ≥110 bpm. Groups did not differ by age, previous cerebrovascular disease, heart failure status, CHA2DS2-VASc scores, renal function, or left ventricular function. There were significant differences in race (P=0.001), sinus node dysfunction (P=0.004), and treatment with calcium-channel blockers (P=0.006) and anticoagulation (P=0.009). In analyses of continuous heart rates, lower heart rate ≤65 bpm was associated with higher all-cause mortality (adjusted hazard ratio [HR], 1.15 per 5-bpm decrease; 95% CI, 1.01 to 1.32; P=0.04). Similarly, increasing heart rate >65 bpm was associated with higher all-cause mortality (adjusted HR, 1.10 per 5-bpm increase; 95% CI, 1.05 to 1.15; P<0.0001). This relationship was consistent across endpoints and in a broader sensitivity analysis of permanent and nonpermanent AF patients. Conclusions Among patients with permanent AF, there is a J-shaped relationship between heart rate and mortality. These data support current guideline recommendations, and clinical trials are warranted to determine optimal rate control. Clinical Trial Registration URL: http://clinicaltrials.gov/. Unique identifier: NCT01165710. PMID:26370445

Increased Heart Rate Is Associated With Higher Mortality in Patients With Atrial Fibrillation (AF): Results From the Outcomes Registry for Better Informed Treatment of AF (ORBIT-AF).

PubMed

Steinberg, Benjamin A; Kim, Sunghee; Thomas, Laine; Fonarow, Gregg C; Gersh, Bernard J; Holmqvist, Fredrik; Hylek, Elaine; Kowey, Peter R; Mahaffey, Kenneth W; Naccarelli, Gerald; Reiffel, James A; Chang, Paul; Peterson, Eric D; Piccini, Jonathan P

2015-09-14

Most patients with atrial fibrillation (AF) require rate control; however, the optimal target heart rate remains under debate. We aimed to assess rate control and subsequent outcomes among patients with permanent AF. We studied 2812 US outpatients with permanent AF in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation. Resting heart rate was measured longitudinally and used as a time-dependent covariate in multivariable Cox models of all-cause and cause-specific mortality during a median follow-up of 24 months. At baseline, 7.4% (n=207) had resting heart rate <60 beats per minute (bpm), 62% (n=1755) 60 to 79 bpm, 29% (n=817) 80 to 109 bpm, and 1.2% (n=33) ≥110 bpm. Groups did not differ by age, previous cerebrovascular disease, heart failure status, CHA2DS2-VASc scores, renal function, or left ventricular function. There were significant differences in race (P=0.001), sinus node dysfunction (P=0.004), and treatment with calcium-channel blockers (P=0.006) and anticoagulation (P=0.009). In analyses of continuous heart rates, lower heart rate ≤65 bpm was associated with higher all-cause mortality (adjusted hazard ratio [HR], 1.15 per 5-bpm decrease; 95% CI, 1.01 to 1.32; P=0.04). Similarly, increasing heart rate >65 bpm was associated with higher all-cause mortality (adjusted HR, 1.10 per 5-bpm increase; 95% CI, 1.05 to 1.15; P<0.0001). This relationship was consistent across endpoints and in a broader sensitivity analysis of permanent and nonpermanent AF patients. Among patients with permanent AF, there is a J-shaped relationship between heart rate and mortality. These data support current guideline recommendations, and clinical trials are warranted to determine optimal rate control. URL: http://clinicaltrials.gov/. Unique identifier: NCT01165710. © 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

Structural architecture of the central Brooks Range foothills, Alaska

USGS Publications Warehouse

Moore, Thomas E.; Potter, Christopher J.; O'Sullivan, Paul B.

2002-01-01

Five structural levels underlie the Brooks Range foothills, from lowest to highest: (1) autochthon, at a depth of ~9 km; (2) Endicott Mountains allochthon (EMA), thickest under the northern Brooks Range (>15 km) and wedging out northward above the autochthon; (3) higher allochthons (HA), with a composite thickness of 1.5+ km, wedging out northward at or beyond the termination of EMA; (4) Aptian-Albian Fortress Mountain Formation (FM), deposited unconformably on deformed EMA and HA and thickening northward into a >7-km-thick succession of deformed turbidites (Torok Formation); (5) gently folded Albian-Cenomanian deltaic deposits (Nanushuk Group). The dominant faulting pattern in levels 2-3 is thin-skinned thrusting and thrust-related folds formed before deposition of Cretaceous strata. These structures are cut by younger steeply south-dipping reverse faults that truncate and juxtapose structural levels 1-4 and expose progressively deeper structural levels to the south. Structural levels 4-5 are juxtaposed along a north-dipping zone of south-vergent folds and thrusts. Stratigraphic and fission-track age data suggest a kinematic model wherein the foothills belt was formed first, by thrusting of HA and EMA as deformational wedges onto the regionally south-dipping authochon at 140-120Ma. After deposition of FM and Torok during mid-Cretaceous hinterland extension and uplift, a second episode of contractional deformation at 60 Ma shortened the older allochthonous deformational wedges (EMA, HA) and overlying strata on north-vergent reverse faults. To the north, where the allochthons wedge out, shortening caused duplexing in the Torok and development of a triangle zone south of the Tuktu escarpment.

Modeling ecohydrologic processes at Hubbard Brook: Initial results for Watershed 6 stream discharge and chemistry

EPA Science Inventory

The Hubbard Brook Long Term Ecological Research site has produced some of the most extensive and long-running databases on the hydrology, biology and chemistry of forest ecosystem responses to climate and forest harvest. We used these long-term databases to calibrate and apply G...

SOIL ALUMINUM DISTRIBUTION IN THE NEAR-STREAM ZONE AT THE BEAR BROOK WATERSHED IN MAINE

EPA Science Inventory

Near-stream and upslope soil chemical properties were analyzed to infer linkages between soil and surface water chemistry at the Bear Brook Watershed in Maine [BBWM]. Organic and mineral soil samples were collected along six 20 m transects perpendicular to the stream and one 200 ...

Sex reversal of brook trout (Salvelinus fontinalis) by 17α-methyltestosterone exposure: A serial experimental approach to determine optimal timing and delivery regimes.

PubMed

Fatima, Shafaq; Adams, Mark; Wilkinson, Ryan

2016-12-01

Commercial culture of Brook trout (Salvelinus fontinalis) in Tasmania was partly abandoned due to sexual maturation of male fish early on during the estuarine rearing phase. Maturation adversely affects body mass, flesh quality and immunocompetency effectively. Sex reversal techniques such as the in-feed addition of a synthetic androgen have proven difficult to adapt in brook trout. An appropriate timing, duration and delivery vehicle for administration of 17α-methyltestosterone (MT) to produce phenotypic males (neomales) from genotypically female brook trout required further investigation. In this study, groups of brook trout eggs (n=1000) maintained at 9.5±0.15-10±0.14°C, were immersed in MT (400μgL -1 ) for four hours on two alternate days (two immersions/group) staggered over a two week period surrounding the hatch of embryos (control groups excluded). The groups were then split and half received MT-supplemented feed for 60days and the other a standard diet. Following an 11 month on-growing period sex phenotypes were determined by gross & histological gonad morphology. The highest proportion of male phenotypes (75%) was found in fish immersed six and four days pre-hatch and subsequently fed a normal diet. Fish fed a MT supplemented diet and immersed in MT showed significantly higher proportions of sterile fish. These data indicate that a pre-hatch immersion-only regime (4-6days pre-hatch at 9.5°C) should be pursued as a target for optimization studies to further refine the effective concentration and duration of exposure to MT for the successful production of neo-male brook trout. Copyright © 2016 Elsevier B.V. All rights reserved.

Assessing the impact of stocking northern-origin hatchery brook trout on the genetics of wild populations in North Carolina

USGS Publications Warehouse

Kazyak, David C.; Rash, Jacob; Lubinski, Barbara A.; King, Tim L.

2018-01-01

The release of hatchery-origin fish into streams with endemics can degrade the genetics of wild populations if interbreeding occurs. Starting in the 1800s, brook trout descendent from wild populations in the northeastern United States were stocked from hatcheries into streams across broad areas of North America to create and enhance fishery resources. Across the southeastern United States, many millions of hatchery-origin brook trout have been released into hundreds of streams, but the extent of introgression with native populations is not well resolved despite large phylogeographic distances between these groups. We used three assessment approaches based on 12 microsatellite loci to examine the extent of hatchery introgression in 406 wild brook trout populations in North Carolina. We found high levels of differentiation among most collections (mean F′ST = 0.718), and among most wild collections and hatchery strains (mean F′ST = 0.732). Our assessment of hatchery introgression was consistent across the three metrics, and indicated that most wild populations have not been strongly influenced by supplemental stocking. However, a small proportion of wild populations in North Carolina appear to have been strongly influenced by stocked conspecifics, or in some cases, may have been founded entirely by hatchery lineages. In addition, we found significant differences in the apparent extent of hatchery introgression among major watersheds, with the Savannah River being the most strongly impacted. Conversely, populations in the Pee Dee River watershed showed little to no evidence of hatchery introgression. Our study represents the first large-scale effort to quantify the extent of hatchery introgression across brook trout populations in the southern Appalachians using highly polymorphic microsatellite markers.

Tatalina AFS, Alaska. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1983-03-01

M’CROCOpy pESLUTONEST CkA~l PH THIS SHEET Af) m r’",I "er-"i cprit, r I ~~~~Tahen 01.-ing ,lt c’, ’ .c,- us. Bel ii % owe i -r LEVEL ~ut with Ier r iNVENTORY...82172 MAR N 62 53 W V558 ELV: 964 FT PAT. PAinTS A-F HOURS SU M &UZED: OOOOZ - 230OZ PER{IOD OF RECORD: HOUPLY OBSERYATION.1: JAN 73 - DEC 81 SLW4MAY OF...NOVEM_ _ _ _ .._ ,- .- ,z. 702315 SA A. i. ts 58 9 STATION LOCATION AND INS’rRUMtNTATION ,HI STORY NUr! TIf E 11T to tw ITLmU am M GS of CEO(IAPNICAL

Sparrevohn AFS, Alaska. Revised Uniform Summary of Surface Weather Observations.

DTIC Science & Technology

1985-09-18

SSURFACE WEATHER OBSERVATIONS SPARREVOHN AFS AK MSC #702350 N 61 06 W155 35 ELEV: 1573 FT PASV PARTS A-F HOURS SUMMARIZED: 0000 - 2300 LST PERIOD OF RECORD...stations around the world. This is the provenance of the number (e.g., MSC 999999) which will appear on future OL-A standard products. D I...AFS Af PEt 7oif of [ COPD : 77-84 MONTH: A W, HO URS4LS3: ALL 7.3 itIts 816181L1F7 IN 6FAFLIF WILCS INs ((I (F IF F G CF b t I, [ CF ŕ 6 1 ,F F F tF7F I

GST M1 GENOTYPE INFLUENCES THE SUSCEPTIBILITY OF MEN TO SPERM DNA DAMAGE ASSOCIATED WITH EXPOSURE TO AIR POLLUTION

EPA Science Inventory

GSTM1 GENOTYPE INFLUENCES THE SUSCEPTIBILITY OF MEN TO SPERM DNA DAMAGE ASSOCIATED WITH EXPOSURE TO AIR POLLUTION. J. Rubes1, SG Selevan2, R. Sram3, DPEvenson4, SD Perreault5. 1VRI, Brno, CR; 2US EPA/ORD/NCEA, Washington, DC; 3IEM AS CR, Prague, CR; 4SDSU, Brookings, SD; 5US EPA...

State University of New York at Stony Brook Main Library Circulation Department Procedures Manual.

ERIC Educational Resources Information Center

Kendrick, Curtis L., Comp.; Lange, Robert, Comp.

Designed to train student circulation desk workers at the State University of New York at Stony Brook's Main Library, this guide details specific procedures and outlines administrative policies. Topics covered include: (1) what circulation is; (2) what is expected of graduate students; (3) the library's opening and closing procedures; (4) who may…

William Graham Brooke (1835-1907): Advocate of Girls' Superior Schooling in Nineteenth-Century Ireland

ERIC Educational Resources Information Center

McCormack, Christopher F.

2015-01-01

This paper examines the role of William Graham Brooke as advocate of women's higher education and access to university. His work as advocate is considered against the religious, political, social and economic backdrop of late nineteenth century Ireland. A barrister, as Clerk in the Lord Chancellor's office, he was centrally involved in the…

The Role of U2AF1 Mutations in the Pathogenesis of Myelodysplastic Syndromes

DTIC Science & Technology

2015-10-01

mutation, U2AF1(S34F), on hematopoiesis and pre-mRNA splicing in vivo, we created doxycycline-inducible U2AF1(WT) and U2AF1(S34F) transgenic mice...U2AF1(S34F) versus U2AF1(WT). Together, these results suggest that mutant U2AF1 expression contributes to the altered hematopoiesis and pre-mRNA...Spliceosome, Mouse Model, Hematopoiesis , RNA-seq, U2AF1 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME

INDEPENDENT CONFIRMATORY SURVEY REPORT FOR THE REACTOR BUILDING, HOT LABORATORY, PRIMARY PUMP HOUSE, AND LAND AREAS AT THE PLUM BROOK REACTOR FACILITY, SANDUSKY, OHIO

DOE Office of Scientific and Technical Information (OSTI.GOV)

Erika N. Bailey

2011-10-10

In 1941, the War Department acquired approximately 9,000 acres of land near Sandusky, Ohio and constructed a munitions plant. The Plum Brook Ordnance Works Plant produced munitions, such as TNT, until the end of World War II. Following the war, the land remained idle until the National Advisory Committee for Aeronautics later called the National Aeronautics and Space Administration (NASA) obtained 500 acres to construct a nuclear research reactor designed to study the effects of radiation on materials used in space flight. The research reactor was put into operation in 1961 and was the first of fifteen test facilities eventuallymore » built by NASA at the Plum Brook Station. By 1963, NASA had acquired the remaining land at Plum Brook for these additional test facilities« less

Decadal responses in soil N dynamics at the Bear Brook Watershed in Maine, USA

Treesearch

Sultana Jefts; Ivan J. Fernandez; Lindwey E. Rustad; D. Bryan Dail

2004-01-01

Atmospheric nitrogen deposition to forested ecosystems is a concern because of both geochemical and biological consequences for ecosystem integrity. High levels of prolonged N deposition can lead to "N saturation" of the ecosystem. The Bear Brook Watershed in Maine is a long-term, paired forested watershed experiment with over a decade of experimental N...

Cloning and characterization of two duplicated interleukin-17A/F2 genes in common carp (Cyprinus carpio L.): Transcripts expression and bioactivity of recombinant IL-17A/F2.

PubMed

Li, Hongxia; Yu, Juhua; Li, Jianlin; Tang, Yongkai; Yu, Fan; Zhou, Jie; Yu, Wenjuan

2016-04-01

Interleukin-17 (IL-17) plays an important role in inflammation and host defense in mammals. In this study, we identified two duplicated IL-17A/F2 genes in the common carp (Cyprinus carpio) (ccIL-17A/F2a and ccIL-17A/F2b), putative encoded proteins contain 140 amino acids (aa) with conserved IL-17 family motifs. Expression analysis revealed high constitutive expression of ccIL-17A/F2s in mucosal tissues, including gill, skin and intestine, their expression could be induced by Aeromonas hydrophila, suggesting a potential role in mucosal immunity. Recombinant ccIL-17A/F2a protein (rccIL-17A/F2a) produced in Escherichia coli could induce the expression of proinflammatory cytokines (IL-1β) and the antimicrobial peptides S100A1, S100A10a and S100A10b in the primary kidney in a dose- and time-dependent manner. Above findings suggest that ccIL-17A/F2 plays an important role in both proinflammatory and innate immunity. Two duplicated ccIL-17A/F2s showed different expression level with ccIL-17A/F2a higher than b, comparison of two 5' regulatory regions indicated the length from anticipated promoter to transcriptional start site (TSS) and putative transcription factor binding site (TFBS) were different. Promoter activity of ccIL-17A/F2a was 2.5 times of ccIL-17A/F2b which consistent with expression results of two genes. These suggest mutations in 5'regulatory region contributed to the differentiation of duplicated genes. To our knowledge, this is the first report to analyze 5'regulatory region of piscine IL-17 family genes. Copyright © 2016 Elsevier Ltd. All rights reserved.

Beale selected for Resilient Energy Demonstration Initiative > U.S. Air

Science.gov Websites

the CMSAF The Book Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games Games Portraits in Courage Portraits In Courage Vol. I Portraits In Courage Vol. II Portraits In Courage

Hospitalizations in patients with atrial fibrillation: an analysis from ROCKET AF.

PubMed

DeVore, Adam D; Hellkamp, Anne S; Becker, Richard C; Berkowitz, Scott D; Breithardt, Guenter; Hacke, Werner; Halperin, Jonathan L; Hankey, Graeme J; Mahaffey, Kenneth W; Nessel, Christopher C; Singer, Daniel E; Fox, Keith A A; Patel, Manesh R; Piccini, Jonathan P

2016-08-01

The high costs associated with treatment for atrial fibrillation (AF) are primarily due to hospital care, but there are limited data to understand the reasons for and predictors of hospitalization in patients with AF. The ROCKET AF trial compared rivaroxaban with warfarin for stroke prophylaxis in AF. We described the frequency of and reasons for hospitalization during study follow-up and utilized Cox proportional hazards models to assess for baseline characteristics associated with all-cause hospitalization. Of 14 171 patients, 14% were hospitalized at least once. Of 2614 total hospitalizations, 41% were cardiovascular including 4% for AF; of the remaining, 12% were for bleeding. Compared with patients not hospitalized, hospitalized patients were older (74 vs. 72 years), and more frequently had diabetes (46 vs. 39%), prior MI (23 vs. 16%), and paroxysmal AF (19 vs. 17%), but less frequently had prior transient ischaemic attack/stroke (49 vs. 56%). After multivariable adjustment, lung disease [hazard ratio (HR) 1.46, 95% confidence interval (CI) 1.29-1.66], diabetes [1.22, (1.11-1.34)], prior MI [1.27, (1.13-1.42)], and renal dysfunction [HR 1.07 per 5 unit GFR < 65 mL/min, (1.04-1.10)] were associated with increased hospitalization risk. Treatment assignment was not associated with differential rates of hospitalization. Nearly 1 in 7 of the moderate-to-high-risk patients with AF enrolled in this trial was hospitalized within 2 years, and both AF and bleeding were rare causes of hospitalization. Further research is needed to determine whether care pathways directed at comorbid conditions among AF patients could reduce the need for and costs associated with hospitalization. © The Author 2016. Published by Oxford University Press on behalf of the European Society of Cardiology.

Experimental Acidification Causes Soil Base-Cation Depletion at the Bear Brook Watershed in Maine

Treesearch

Ivan J. Fernandez; Lindsey E. Rustad; Stephen A. Norton; Jeffrey S. Kahl; Bernard J. Cosby

2003-01-01

There is concern that changes in atmospheric deposition, climate, or land use have altered the biogeochemistry of forests causing soil base-cation depletion, particularly Ca. The Bear Brook Watershed in Maine (BBWM) is a paired watershed experiment with one watershed subjected to elevated N and S deposition through bimonthly additions of (NH4)2SO4. Quantitative soil...

AF RPA Training: Utility and Tradition in Conflict

DTIC Science & Technology

2017-06-01

The AF and the Army offer competing views on the future of UAS training . Both services export its cultural values, as the Navy, USMC, and...and visions. Despite common technologies, each service approached UAS from different starting points, and created different training models. The AF...issues reflected different approaches each service took to Unmanned Aerial Systems (UAS) operational employment, personnel management, and training

Installation Restoration Program Stage 3. Remedial Investigation/ Feasibility Study Elmendorf AFB, Alaska. Volume 2. Section 5 - Bibliography Text

DTIC Science & Technology

1990-05-01

ELME’IDORF AFB, AK UNITED STATES AIR FORCE OCCUPATIONAL & ENVIRONMENTAL HEALTH LABORATORY (AFSC) ilb(. IiCAL Sr.(VICES DIVISION (AFOEHLi £3) I BROOKS AIR...UNITED STATES AIR FORCE OCCUPATIONAL AND ENVIRONMENTAL HEALTH LABORATORY (AFSC) TECHNICAL SERVICES DIVISION (AFOEHL/TS) BROOKS AIR FORCE BASE, TEXAS...the following criteria: technical feasibility, institutional requirements, environmental impacts, public health impacts, and cost. This Alternative

Accuracy of Prediction Equations to Assess Percentage of Body Fat in Children and Adolescents with Down Syndrome Compared to Air Displacement Plethysmography

ERIC Educational Resources Information Center

Gonzalez-Aguero, A.; Vicente-Rodriguez, G.; Ara, I.; Moreno, L. A.; Casajus, J. A.

2011-01-01

To determine the accuracy of the published percentage body fat (%BF) prediction equations (Durnin et al., Johnston et al., Brook and Slaughter et al.) from skinfold thickness compared to air displacement plethysmography (ADP) in children and adolescents with Down syndrome (DS). Twenty-eight children and adolescents with DS (10-20 years old; 12…

U.S. Air Force > About Us > Observances

Science.gov Websites

Media Sites Site Registration Contact Us Search AF.mil: Highlights APIM-Rotator Womens History Month African American History Month posters African American History Month Asian American Pacific Islander . (U.S. Air Force photo by Staff Sgt. Will McCrary/Released). USAFE band member discovers family history

Learning to Communicate Science: Stony Brook University's Approach

NASA Astrophysics Data System (ADS)

Bass, E.

2012-12-01

Stony Brook University offers an unusual series of short courses to help science graduate students learn to communicate more effectively about science with people outside their disciplines, including the public, public officials, potential funders and employers, students, the press, and colleagues in other fields. The courses include six 1-credit (14-hour) modules in oral and written communication that rely on practice and interactive feedback. More than 120 master's and PhD students, from more than 16 departments, have taken at least one of the courses since spring 2011. Most students who try one module end up taking two or three. An additional course for medical and nursing students was added in fall 2012. The courses are offered in the School of Journalism and were developed by the Center for Communicating Science (CCS). CCS was founded in 2009, with the participation of Alan Alda, the actor, writer, and longtime advocate for science, who is a Visiting Professor at Stony Brook. The Communicating Science courses have received strong institutional support and enthusiastic reviews. They are required by two programs, an MA in Marine Conservation and Policy and an Advanced Certificate in Health Communications. Two successive Provosts have subsidized course costs for PhD students, and Graduate School leaders are working to establish a steady funding stream to allow expansion of the program. Our aspiration at CCS is for every science graduate student to receive some training in communicating about science to the public. Several factors have helped in establishing the program: --CCS' multidisciplinary nature helped build support, with participation by faculty from across the campus, including not only the natural sciences, engineering, and medicine, but journalism, theatre arts, and the Writing Program, as well as nearby Brookhaven National Laboratory and Cold Spring Harbor Laboratory. --Before offering courses, CCS conducted all-day workshops and high

Modeling the impact of climate warming on the range of brook trout in the Blue Ridge Mountains, USA

NASA Astrophysics Data System (ADS)

Bartlett, M. G.

2012-12-01

Brook trout in the Eastern United States (Salvelinus fontinalis) thrive in a relatively narrow range of stream temperatures. Over the past several centuries, the introduction of competitive species has pushed brook trout to the cooler, upstream margins of what use to be a much more extensive range within most drainages. Over the next several decades, climate change may put further thermal pressure on the species, increasing the fragmentation of their distribution and shrinking their present range. Because the size and connectivity of habitats seem to influence the persistence of local populations, climate warming leading to increased fragmentation of remaining habitats could accelerated species decline. Using the Regional Hydrological and Ecological Simulation System (RHYSSys), I modeled the projected habitat changes for a group of native brook trout streams in the Blue Ridge Mountains of South-Central Virginia, USA. The modeling process is illustrative of the need for better understanding of the couplings that exist between geomorphology, hydrology, and ecology, particularly in mountain environments. Model results are quantified according to the degree of decrease in stream-miles of habitat and the increase in the fragmentation of the habitat as a function of the warming rate (degrees per decade). These results may help inform habitat management strategies for the coming several decades in the region, and the modeling process helps highlight the need for more refined understanding of climate change's impacts on habitability.

Air Force Journal of Logistics. Volume 28, Number 3, Fall 2004

DTIC Science & Technology

2004-01-01

Globa Co C S ystem A -us So 0 5 S a 0- S ~ ~ ~ ~ n 0 S *m Cota enyOertos C0 htp /w w afIm .h a.m i /gjAf I ho e- t al20 AIR FORCE JOURNAL LOGISTICS...be edited in accordance with the AFJL Manual for Style. Articles in this edition may be reproduced in whole or in part without permission. If... interpreting this clause. The Army Kuwait or in the country of origin. In the case of the Intelligence required contract and civilian personnel to sign for

Refinement of detecting atrial fibrillation in stroke patients: results from the TRACK-AF Study.

PubMed

Reinke, F; Bettin, M; Ross, L S; Kochhäuser, S; Kleffner, I; Ritter, M; Minnerup, J; Dechering, D; Eckardt, L; Dittrich, R

2018-04-01

Detection of occult atrial fibrillation (AF) is crucial for optimal secondary prevention in stroke patients. The AF detection rate was determined by implantable cardiac monitor (ICM) and compared to the prediction rate of the probability of incident AF by software based analysis of a continuously monitored electrocardiogram at follow-up (stroke risk analysis, SRA); an optimized AF detection algorithm is proposed by combining both tools. In a monocentric prospective study 105 out of 389 patients with cryptogenic stroke despite extensive diagnostic workup were investigated with two additional cardiac monitoring tools: (a) 20 months' monitoring by ICM and (b) SRA during hospitalization at the stroke unit. The detection rate of occult AF was 18% by ICM (n = 19) (range 6-575 days) and 62% (n = 65) had an increased risk for AF predicted by SRA. When comparing the predictive accuracy of SRA to ICM, the sensitivity was 95%, specificity 35%, positive predictive value 27% and negative predictive value 96%. In 18 patients with AF detected by ICM, SRA also showed a medium risk for AF. Only one patient with a very low risk predicted by SRA developed AF revealed by ICM after 417 days. A combination of SRA and ICM is a promising strategy to detect occult AF. SRA is reliable in predicting incident AF with a high negative predictive value. Thus, SRA may serve as a cost-effective pre-selection tool identifying patients at risk for AF who may benefit from further cardiac monitoring by ICM. © 2017 EAN.

X-linked mental retardation syndrome: Three brothers with the Brooks-Wisniewski-Brown syndrome

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morava, E.; Storcz, J.; Kosztolanyi, G.

1996-07-12

We report on 3 brothers with growth and mental retardation, bifrontal narrowness, short palpebral fissures, deeply set eyes with entropion, wide bulbous nose, small mouth, myopia, and spastic diplegia. The patients were born to normal and non-consanguineous parents. The similarity of our cases with those recently reported by Brooks et al. supports their suggestion that these patients are representative of a distinct entity. 8 refs., 3 figs., 1 tab.

SEX-LINKED CHANGES IN PHASE 1 BIOTRANSFORMATION OF PHENOL IN BROOK TROUT OVER AN ANNUAL REPRODUCTIVE CYCLE

EPA Science Inventory

The microsomal metabolism of phenol (11 degrees C) over an annual reproductive cycle from June to December has been studied using fall spawning adult brook trout (Salvelinus fontinalis). Incubations were optimized for time, cofactor connection, pH, and microsomal protein concentr...

Effects of Iron Depletion on CALM-AF10 Leukemias

PubMed Central

Heath, Jessica L.; Weiss, Joshua M.

2014-01-01

Iron, an essential nutrient for cellular growth and proliferation, enters cells via clathrin-mediated endocytosis (CME). The clathrin assembly lymphoid myeloid (CALM) protein plays an essential role in the cellular import of iron by CME. CALM-AF10 leukemias harbor a single copy of the normal CALM gene, and may therefore be more sensitive to the growth inhibitory effect of iron restriction compared with normal hematopoietic cells. We found that Calm heterozygous (CalmHET) murine fibroblasts exhibit signs of iron deficiency, with increased surface transferrin receptor (sTfR) levels and reduced growth rates. CalmHET hematopoietic cells are more sensitive in vitro to iron chelators than their wild type counterparts. Iron chelation also displayed toxicity towards cultured CalmHET CALM-AF10 leukemia cells and this effect was additive to that of chemotherapy. In mice transplanted with CalmHET CALM-AF10 leukemia, we found that dietary iron restriction reduces tumor burden in the spleen. However, dietary iron restriction, used alone or in conjunction with chemotherapy, did not increase survival of mice with CalmHET CALM-AF10 leukemia. In summary, while Calm heterozygosity results in iron deficiency and increased sensitivity to iron chelation in vitro, our data in mice do not suggest that iron depletion strategies would be beneficial for the therapy of CALM-AF10 leukemia patients. PMID:25193880

Unique wing scale photonics of male Rajah Brooke's birdwing butterflies.

PubMed

Wilts, Bodo D; Giraldo, Marco A; Stavenga, Doekele G

2016-01-01

Ultrastructures in butterfly wing scales can take many shapes, resulting in the often striking coloration of many butterflies due to interference of light. The plethora of coloration mechanisms is dazzling, but often only single mechanisms are described for specific animals. We have here investigated the male Rajah Brooke's birdwing, Trogonoptera brookiana, a large butterfly from Malaysia, which is marked by striking, colorful wing patterns. The dorsal side is decorated with large, iridescent green patterning, while the ventral side of the wings is primarily brown-black with small white, blue and green patches on the hindwings. Dense arrays of red hairs, creating a distinct collar as well as contrasting areas ventrally around the thorax, enhance the butterfly's beauty. The remarkable coloration is realized by a diverse number of intricate and complicated nanostructures in the hairs as well as the wing scales. The red collar hairs contain a broad-band absorbing pigment as well as UV-reflecting multilayers resembling the photonic structures of Morpho butterflies; the white wing patches consist of scales with prominent thin film reflectors; the blue patches have scales with ridge multilayers and these scales also have centrally concentrated melanin. The green wing areas consist of strongly curved scales, which possess a uniquely arranged photonic structure consisting of multilayers and melanin baffles that produces highly directional reflections. Rajah Brooke's birdwing employs a variety of structural and pigmentary coloration mechanisms to achieve its stunning optical appearance. The intriguing usage of order and disorder in related photonic structures in the butterfly wing scales may inspire novel optical materials as well as investigations into the development of these nanostructures in vivo.

Environmental Assessment: Western Range Instrumentation Modernization Program Vandenberg Air Force Base, Santa Barbara County, and Pillar Point Air Force Station, San Mateo County California

DTIC Science & Technology

2008-09-03

Force Base ( AFB ), and Pillar Point Air Force Station (AFS), California. The 30th Space Wing at Vandenberg AFB operates the Western Launch and Test...Range (Western Range). The Western Range begins at the coastal boundaries of Vandenberg AFB and extends westward to the Marshall Islands, including...Vandenberg AFB . Vandenberg AFB is headquarters to the 30th Space Wing, the Air Force Space Command unit that operates Vandenberg AFB and the Western

Hydrogen ion input to the Hubbard Brook Experimental Forest, New Hampshire, during the last decade

Treesearch

Gene E. Likens; F. Herbert Bormann; John S. Eaton; Robert S. Pierce; Noye M. Johnson

1976-01-01

Being downwind of eastern and midwestern industrial centers, the Hubbard Brook Experimental Forest offers a prime location to monitor long-term trends in atmospheric chemistry. Continuous measurements of precipitation chemistry during the last 10 years provide a measure of recent changes in precipitation inputs of hydrogen ion. The weighted average pH of precipitation...

Termination of persistent atrial fibrillation during pulmonary vein isolation: insight from the MAGIC-AF trial.

PubMed

Singh, Sheldon M; d'Avila, Andre; Kim, Young-Hoon; Aryana, Arash; Mangrum, J Michael; Michaud, Gregory F; Dukkipati, Srinivas R; Barrett, Conor D; Heist, E Kevin; Parides, Michael K; Thorpe, Kevin E; Reddy, Vivek Y

2017-10-01

Controversy on the optimal ablation strategy for persistent atrial fibrillation (AF) exists with limited work evaluating a strategy of pulmonary vein isolation (PVI) alone when AF terminates during PVI. Thirty-five patients had AF termination during PVI in the Modified Ablation Guided by Ibutilide Use in Chronic Atrial Fibrillation (MAGIC-AF; ClinicalTrials.gov number: NCT01014741) study. The objective of the current study is to report the 1-year outcome after PVI alone in this unique patient group. The 1-year single procedure freedom from atrial arrhythmia off anti-arrhythmic drugs was reported for the 35 patients in the MAGIC-AF study with persistent AF termination during or upon completion of PVI. Freedom from recurrent atrial arrhythmia was achieved in 60% of patients where AF terminated during PVI. Cavotricuspid isthmus flutter was common when AF terminated to a macro re-entrant flutter during PVI, and responsible for 92% of all flutter circuits with AF termination. Persistent AF termination during PVI may identify a subgroup of patients who experience a similar long-term clinical outcome with PVI ablation alone when compared with other more extensive persistent AF ablation strategies. Pulmonary vein isolation alone may be an appropriate tactic in this subgroup of persistent AF patients. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.

Water age and stream solute dynamics at the Hubbard Brook Experimental Forest (US)

NASA Astrophysics Data System (ADS)

Botter, Gianluca; Benettin, Paolo; McGuire, Kevin; Rinaldo, Andrea

2016-04-01

The contribution discusses experimental and modeling results from a headwater catchment at the Hubbard Brook Experimental Forest (New Hampshire, USA) to explore the link between stream solute dynamics and water age. A theoretical framework based on water age dynamics, which represents a general basis for characterizing solute transport at the catchment scale, is used to model both conservative and weathering-derived solutes. Based on the available information about the hydrology of the site, an integrated transport model was developed and used to estimate the relevant hydrochemical fluxes. The model was designed to reproduce the deuterium content of streamflow and allowed for the estimate of catchment water storage and dynamic travel time distributions (TTDs). Within this framework, dissolved silicon and sodium concentration in streamflow were simulated by implementing first-order chemical kinetics based explicitly on dynamic TTD, thus upscaling local geochemical processes to catchment scale. Our results highlight the key role of water stored within the subsoil glacial material in both the short-term and long-term solute circulation at Hubbard Brook. The analysis of the results provided by the calibrated model allowed a robust estimate of the emerging concentration-discharge relationship, streamflow age distributions (including the fraction of event water) and storage size, and their evolution in time due to hydrologic variability.

United States Air Force Summer Research Program -- 1993 Summer Research Program Final Reports. Volume 12. Armstrong Laboratory

DTIC Science & Technology

1993-01-01

Panasonic TLD . Panasonic Industrial Company; Secaucus, New Jersey. 5. Thurlow, Ronald M. "Neutron Dosimetry Using a Panasonic Thermoluminescent Dosimeter." A...steps 8-12. 29-15 THE BUILDING OF THE USAF PANASONIC UD-809AS ALGORITHM Katherine M. Arnold Research Associate Radiation Dosimetry Branch Brooks Air...Research August 1993 30-1 THE BUILDING OF THE USAF PANASONIC UD-809AS ALGORITHM Katherine M. Arnold Research Associate Radiation Dosimetry Branch

National Program for Inspection of Non-Federal Dams. Farm Brook Site 2A Dam (CT 01546), Connecticut Coastal Basin, Hamden, Connecticut. Phase I Inspection Report.

DTIC Science & Technology

1981-09-01

01546 NAME OF DAM: Farm Brook Site 2A Darn TO4N: Hamden COUNTY AND STATE: New Haven County, Connecticut STREAM: Wilmot Brook *DATE OF INSPECTION...few lives. Therefore, an emergency operation plan, including a downstream warning system should be prepared and implemented. It is recommended that...3.2 Evaluation 3-4 4. OPERATIONAL & MAINTENANCE PROCEDURES - 4.1 Operational Procedures 4-1 a. General b. Description of any Warning System in Effect

WHAT DOESNT GET MEASURED - DOESNT GET DONE: IMPLEMENTING CONTINUOUS PROCESS IMPROVEMENT IN THE AIR FORCE RESERVE

DTIC Science & Technology

2016-04-01

Practical Problem Solving Method RMD Resource Management Decision ROI Return on Investment SECAF Secretary of the Air Force SECNAV Secretary of...AFSO21 and now AF CPI, this program seeks to train and certify an organic cadre of CPI practitioners to support the use of its standard problem solving ...process known as the AF Practical Problem Solving Method (PPSM) to solve mission critical process deficiencies. The PPSM leverages several industry

Rainbow trout versus brook trout biomass and production under varied climate regimes in small southern Appalachian streams

Treesearch

Bonnie. J.E. Myers; C. Andrew Dolloff; Andrew L. Rypel

2014-01-01

Many Appalachian streams historically dominated by Brook Trout Salvelinus fontinalis have experienced shifts towards fish communities dominated by Rainbow Trout Onchorhynchus mykiss. We used empirical estimates of biomass and secondary production of trout conspecifics to evaluate species success under varied thermal regimes. Trout...

Improving Air Force Depot Programming by Linking Resources to Capabilities

DTIC Science & Technology

2012-01-01

thank Rick Grisenthwaite at Warner Robins Air Logistics Center, Jamie Jeter at Okla- homa City Air Logistics Center, and Glen Brown at Ogden Air...consistency, we use the term block cycle instead of SCU in our F-16 discussions. 4 8 Im p ro vin g A ir Fo rce D ep o t Pro g ram m in g b y Lin kin...Requirements RAND TR905-B.8 Figure B.9 Depot Purchased Equipment Maintenance Model Output: Projected Aircraft Availability RAND TR905-B.9 A ir cr af t av

Extracting uranium from seawater: Promising AF series adsorbents

DOE PAGES

Das, Sadananda; Oyola, Y.; Mayes, Richard T.; ...

2015-11-02

Here, a new family of high surface area polyethylene fiber adsorbents (AF series) was recently developed at the Oak Ridge National Laboratory (ORNL). The AF series of were synthesized by radiation-induced graft polymerization of acrylonitrile and itaconic acid (at different monomer/co-monomer mol ratios) onto high surface area polyethylene fibers. The degree of grafting (%DOG) of AF series adsorbents was found to be 154 354%. The grafted nitrile groups were converted to amidoxime groups by treating with hydroxylamine. The amidoximated adsorbents were then conditioned with 0.44M KOH at 80 C followed by screening at ORNL with simulated seawater spiked with 8more » ppm uranium. Uranium adsorption capacity in simulated seawater screening ranged from 170-200 g-U/kg-ads irrespective of %DOG. A monomer/co-monomer mol ratio in the range of 7.57-10.14 seemed to be optimum for highest uranium loading capacity. Subsequently, the adsorbents were also tested with natural seawater at Pacific Northwest National Laboratory (PNNL) using flow-through exposure uptake experiments to determine uranium loading capacity with varying KOH conditioning time at 80 C. The highest adsorption capacity of AF1 measured after 56 days of marine testing was demonstrated as 3.9 g-U/kg-adsorbent and 3.2 g-U/kg-adsorbent for 1hr and 3hrs of KOH conditioning at 80 C, respectively. Based on capacity values of several AF1 samples, it was observed that changing KOH conditioning from 3hrs to 1hr at 80 C resulted in 22-27% increase in uranium loading capacity in seawater.« less

Extracting Uranium from Seawater: Promising AF Series Adsorbents

DOE Office of Scientific and Technical Information (OSTI.GOV)

Das, S.; Oyola, Y.; Mayes, Richard T.

A new family of high-surface-area polyethylene fiber adsorbents named the AF series was recently developed at the Oak Ridge National Laboratory (ORNL). The AF series adsorbents were synthesized by radiation-induced graft polymerization of acrylonitrile and itaconic acid (at different monomer/comonomer mol ratios) onto high surface area polyethylene fibers. The degree of grafting (%DOG) of AF series adsorbents was found to be 154-354%. The grafted nitrile groups were converted to amidoxime groups by treating with hydroxylamine. The amidoximated adsorbents were then conditioned with 0.44 M KOH at 80 °C followed by screening at ORNL with sodium-based synthetic aqueous solution, spiked withmore » 8 ppm uranium. The uranium adsorption capacity in simulated seawater screening ranged from 170 to 200 g-U/kg-ads irrespective of %DOG. A monomer/comonomer molar ratio in the range of 7.57-10.14 seemed to be optimum for highest uranium loading capacity. Subsequently, the adsorbents were also tested with natural seawater at Pacific Northwest National Laboratory (PNNL) using flow-through column experiments to determine uranium loading capacity with varying KOH conditioning times at 80 °C. The highest adsorption capacity of AF1 measured after 56 days of marine testing was demonstrated as 3.9 g-U/kg-adsorbent and 3.2 g-U/kg-adsorbent for 1 and 3 h of KOH conditioning at 80 °C, respectively. Based on capacity values of several AF1 samples, it was observed that changing KOH conditioning from 1 to 3 h at 80 °C resulted in a 22-27% decrease in uranium adsorption capacity in seawater.« less

Extracting uranium from seawater: Promising AF series adsorbents

DOE Office of Scientific and Technical Information (OSTI.GOV)

Das, Sadananda; Oyola, Y.; Mayes, Richard T.

Here, a new family of high surface area polyethylene fiber adsorbents (AF series) was recently developed at the Oak Ridge National Laboratory (ORNL). The AF series of were synthesized by radiation-induced graft polymerization of acrylonitrile and itaconic acid (at different monomer/co-monomer mol ratios) onto high surface area polyethylene fibers. The degree of grafting (%DOG) of AF series adsorbents was found to be 154 354%. The grafted nitrile groups were converted to amidoxime groups by treating with hydroxylamine. The amidoximated adsorbents were then conditioned with 0.44M KOH at 80 C followed by screening at ORNL with simulated seawater spiked with 8more » ppm uranium. Uranium adsorption capacity in simulated seawater screening ranged from 170-200 g-U/kg-ads irrespective of %DOG. A monomer/co-monomer mol ratio in the range of 7.57-10.14 seemed to be optimum for highest uranium loading capacity. Subsequently, the adsorbents were also tested with natural seawater at Pacific Northwest National Laboratory (PNNL) using flow-through exposure uptake experiments to determine uranium loading capacity with varying KOH conditioning time at 80 C. The highest adsorption capacity of AF1 measured after 56 days of marine testing was demonstrated as 3.9 g-U/kg-adsorbent and 3.2 g-U/kg-adsorbent for 1hr and 3hrs of KOH conditioning at 80 C, respectively. Based on capacity values of several AF1 samples, it was observed that changing KOH conditioning from 3hrs to 1hr at 80 C resulted in 22-27% increase in uranium loading capacity in seawater.« less

A Retrospective Analysis of Initial Posterior Root Canal Therapy on United States Air Force Personnel

DTIC Science & Technology

2016-06-01

and John Yaccino, DDS Abstract Introduction: The Air Force Dental Service (AFDS) has established evidence-based treatment standards for endodontics...and cuspal coverage restorations (4-6). With this research, the Air Force Dental Service (AFDS) established evidence-based treatment standards for...endodontics to ensure Airmen receive high-quality, safe dental care (7). These standards are taught at the two Air Force (AF) Postgraduate Endodontic

CERN’s AFS replacement project

NASA Astrophysics Data System (ADS)

Iven, J.; Lamanna, M.; Pace, A.

2017-10-01

OpenAFS is the legacy solution for a variety of use cases at CERN, most notably home-directory services. OpenAFS has been used as the primary shared file-system for Linux (and other) clients for more than 20 years, but despite an excellent track record, the project’s age and architectural limitations are becoming more evident. We are now working to offer an alternative solution based on existing CERN storage services. The new solution will offer evolved functionality, and is expected to eventually benefit from operational synergies. In this paper we will present CERN’s usage and an analysis of our technical choices: we will focus on the alternatives chosen for the various use cases (among them EOS, CERNBox and CASTOR); on implementing the migration process over the coming years; and the challenges and opportunities of the migration.

Decentralizing Centralized Control: Reorienting a Fundamental Tenet for Resilient Air Operation

DTIC Science & Technology

2008-05-22

Forward Air Controller FBIS Foreign Broadcast Information Service FCC Functional Component Commander FM Field Manual GBU - 39 Guided Bomb Unit - 39...Diameter Bomb ( GBU - 39 ) TEG Test and Evaluation Group TST Time Sensitive Target UAV Unmanned Aerial Vehicle USAF United States Air Force USAFWS United...www.afmc.af.mil/news/story.asp?id=123017916 (accessed November 11, 2007). Recent fielding of the GBU - 39 , Small Diameter Bomb (SDB), enables a

Growth of a Science Center: The Center for Science and Mathematics Education (CESAME) at Stony Brook University

ERIC Educational Resources Information Center

Gafney, Leo; Bynum, R. David; Sheppard, Keith

2015-01-01

This report describes the origin and development of CESAME (The Center for Science and Mathematics Education) at Stony Brook University. The analysis identifies key ingredients in areas of personnel, funding, organizational structures, educational priorities, collaboration, and institutionalization. After a discussion of relevant issues in…

Tectonic evolution of the central Brooks Range mountain front: Evidence from the Atigun Gorge region

USGS Publications Warehouse

Mull, C.G.; Glenn, R.K.; Adams, K.E.

1997-01-01

Atigun Gorge, at the northern front of the eastern Endicott Mountains, contains well-exposed rocks of the upper part of the Endicott Mountains allochthon and rocks of the structurally higher Picnic Creek or Ipnavik River allochthon. These allochthons contain rocks as young as Early Cretaceous (Valanginian) and are separated by a nearly vertical fault zone that contains exotic blocks of Triassic and Jurassic chert and silicified mudstone. Siliceous rocks of this type are not present in the Endicott Mountains allochthon but are characteristic of the Picnic Creek, Ipnavik River, and some of the other allochthons that structurally overlie the Endicott Mountains allochthon in the central and western Brooks Range. These exotic blocks, therefore indicate that structurally higher rocks of either the Picnic Creek or Ipnavik River allochthon were emplaced during the Early Cretaceous and are preserved along the northern flank of the eastern Endicott Mountains. The deformed thickness of this higher allochthon in the subsurface north of the mountains is unknown but probably exceeds 2 kilometers. Similar relations are mapped east of Atigun Gorge in an area of structural transition from the eastern Endicott Mountains into the northern Philip Smith Mountains, which are formed by the parautochthonous North Slope stratigraphic assemblage. The allochthonous rocks at the mountain front are regionally unconformably overlain by proximal Lower Cretaceous (Albian) foredeep conglomerate at the southern flank of the Colville basin, but at Atigun Gorge, the base of these deposits is interpreted as a possible back thrust at a triangle zone. Conglomerate clasts in the foredeep deposits are dominantly chert, mafic igneous rock, and other lithologies characteristic of the Picnic Creek and Ipnavik River allochthons and scattered clasts from the Endicott Mountains allochthon. The conglomerates show that the chert-rich allochthonous rocks and the Endicott Mountains allochthon were emplaced in the

U2AF1 mutations alter splice site recognition in hematological malignancies.

PubMed

Ilagan, Janine O; Ramakrishnan, Aravind; Hayes, Brian; Murphy, Michele E; Zebari, Ahmad S; Bradley, Philip; Bradley, Robert K

2015-01-01

Whole-exome sequencing studies have identified common mutations affecting genes encoding components of the RNA splicing machinery in hematological malignancies. Here, we sought to determine how mutations affecting the 3' splice site recognition factor U2AF1 alter its normal role in RNA splicing. We find that U2AF1 mutations influence the similarity of splicing programs in leukemias, but do not give rise to widespread splicing failure. U2AF1 mutations cause differential splicing of hundreds of genes, affecting biological pathways such as DNA methylation (DNMT3B), X chromosome inactivation (H2AFY), the DNA damage response (ATR, FANCA), and apoptosis (CASP8). We show that U2AF1 mutations alter the preferred 3' splice site motif in patients, in cell culture, and in vitro. Mutations affecting the first and second zinc fingers give rise to different alterations in splice site preference and largely distinct downstream splicing programs. These allele-specific effects are consistent with a computationally predicted model of U2AF1 in complex with RNA. Our findings suggest that U2AF1 mutations contribute to pathogenesis by causing quantitative changes in splicing that affect diverse cellular pathways, and give insight into the normal function of U2AF1's zinc finger domains. © 2015 Ilagan et al.; Published by Cold Spring Harbor Laboratory Press.

Persistent Atrial Fibrillation Ablation in Females: Insight from the MAGIC-AF Trial.

PubMed

Singh, Sheldon M; D'Avila, Andre; Aryana, Arash; Kim, Young-Hoon; Mangrum, J Michael; Michaud, Gregory F; Dukkipati, Srinivas R; Heist, E Kevin; Barrett, Conor D; Thorpe, Kevin E; Reddy, Vivek Y

2016-07-27

Atrial fibrillation (AF) ablation is less frequently performed in women when compared to men. There are conflicting data on the safety and efficacy of AF ablation in women. The objective of this study was to compare the clinical characteristics and outcomes in a contemporary cohort of men and women undergoing persistent AF ablation procedures. A total of 182 men and 53 women undergoing a first-ever persistent AF catheter ablation procedure in The Modified Ablation Guided by Ibutilide Use in Chronic Atrial Fibrillation (MAGIC-AF) trial were evaluated. Clinical and procedural characteristics were compared between each gender. The primary efficacy endpoint was the 1-year single procedure freedom from atrial arrhythmia off anti-arrhythmic drugs. Women undergoing catheter ablation procedures were older than men (P < 0.001). The duration of AF and associated co-morbidities were similar between both genders. Single procedure drug-free atrial arrhythmia recurrence occurred in 53% of the cohort with no difference based on gender (men = 54%, women = 53%; P = 1.0). Procedural (P = 0.04), fluoroscopic (P = 0.02), and ablation times (P = 0.003) were shorter in women compared to men. Periprocedural complications and postablation improvement in quality of life were similar between men and women. Women undergoing a first-ever persistent AF ablation procedure were older but had similar clinical outcomes and complications when compared with men. © 2016 Wiley Periodicals, Inc.

A Decision Support Model Using Life Cycle Cost (LCC) Analysis to Select Cost-Effective Alternatives for Hazardous Materials

DTIC Science & Technology

1993-09-01

AF89-071. Washington: GPO, 1989. 159 14. Diaz , SSgt Laura, 648 Med Sq/SGHL. Personal interview. Brooks AFB, San Antonio TX, 14 July 1993. 15. EA...Training Strateav of the Acauisition Management of Hazardous Materials Program. Draft Report. McLean VA, August 1991. 36. Moore, SSgt Alicia . AL/OEVP

Embossed Teflon AF Laminate Membrane Microfluidic Diaphragm Valves

NASA Technical Reports Server (NTRS)

Willis, Peter; Hunt, Brian; White,Victor; Grunthaner, Frank

2008-01-01

A microfluidic system has been designed to survive spaceflight and to function autonomously on the Martian surface. It manipulates microscopic quantities of liquid water and performs chemical analyses on these samples to assay for the presence of molecules associated with past or present living processes. This technology lies at the core of the Urey Instrument, which is scheduled for inclusion on the Pasteur Payload of the ESA ExoMars rover mission in 2013. Fabrication processes have been developed to make the microfabricated Teflon-AF microfluidic diaphragm pumps capable of surviving extreme temperature excursions before and after exposure to liquid water. Two glass wafers are etched with features and a continuous Teflon membrane is sandwiched between them (see figure). Single valves are constructed using this geometry. The microfabricated devices are then post processed by heating the assembled device while applying pneumatic pressure to force the Teflon diaphragm against the valve seat while it is softened. After cooling the device, the embossed membrane retains this new shape. This solves previous problems with bubble introduction into the fluid flow where deformations of the membrane at the valve seat occurred during device bonding at elevated temperatures (100-150 C). The use of laminated membranes containing commercial Teflon AF 2400 sheet sandwiched between spun Teflon AF 1600 layers performed best, and were less gas permeable than Teflon AF 1600 membranes on their own. Spinning Teflon AF 1600 solution (6 percent in FLOURINERT(Registered TradeMark) FC40 solvent, 3M Company) at 500 rpm for 1.5 seconds, followed by 1,000 rpm for 3 seconds onto Borofloat glass wafers, results in a 10-micron-thick film of extremely smooth Teflon AF. This spinning process is repeated several times on flat, blank, glass wafers in order to gradually build a thick, smooth membrane. After running this process at least five times, the wafer and Teflon coating are heated under vacuum

Maintenance of phenotypic variation: repeatibility, heritability, and size-dependent processes in a wild brook trout population

Treesearch

Benjamin H. Letcher; Jason A Coombs; Keith H. Nislow

2011-01-01

Phenotypic variation in body size can result from within-cohort variation in birth dates, among-individual growth variation and size-selective processes. We explore the relative effects of these processes on the maintenance of wide observed body size variation in stream-dwelling brook trout (Salvelinus fontinalis). Based on the analyses of multiple...

State University of New York Stony Brook University Hospital: Selected Expenditure Controls. Report 92-S-66.

ERIC Educational Resources Information Center

New York State Office of the Comptroller, Albany. Div. of Management Audit.

An audit was done of selected expenditure controls at the State University of New York (SUNY) at Stony Brook University Hospital particularly payroll costs and procurement practices. The Hospital reported an operating loss of $24 million in 1992. The audit reviewed Hospital management and staff and applicable policies and procedures as well as…

Structure and thermochronology of the metamorphic core of the Brooks Range, Alaska

NASA Astrophysics Data System (ADS)

Toro, Jaime

1999-11-01

Detailed field studies were undertaken in two key areas of the Central Belt of the Brooks Range: (1) the north flank of Mt. Igikpak in the Survey Pass Quadrangle and (2) in the Shishakshinovik Pass area in the eastern Ambler River Quadrangle. In both areas structural, stratigraphic, petrologic, 40Ar/39Ar, apatite fission-track and U-Pb data were used to constrain the kinematic and thermal history of metamorphic rocks of those areas. North of the Mt. Igikpak massif a crustal section ˜15 km thick is exposed. There are upper greenschist facies rocks in the deeper portions, and very low grade metamorphic rocks at higher structural levels. Two foliations are found: a higher grade relict S1 fabric and a lower grade S 2 fabric that controls the metamorphic layering. 40Ar/ 39Ar analyses from S1 white mica in the low-grade rocks at the northern end of the transect indicate that peak M1 metamorphism occurred before ˜112 Ma. We ascribe M1 to shortening that occurred during collision of an island arc against the Arctic Alaska margin. S 2 involved the retrogression of earlier assemblages. Kinematic indicators on S2 are top-to-the-north. A rapid cooling event from 500 +/- 50°C to 300 +/- 50°C took place between ˜98 and ˜90 Ma. The driving mechanism for ductile deformation during S2, and for rapid cooling documented by our thermochronologic data, was probably the gravitational collapse of the core of the orogen, over-thickened during the preceding collision. At Shishakshinovik Pass there are Mississippian Lisburne Group strata surrounded by metamorphic rocks typical of the Central Belt of the Brooks Range. All the rocks at Shishakshinovik Pass are intensely deformed, so that one cannot distinguish between an autochthonous and an allochthonous sequence. Furthermore the Mississippian rocks, instead of being attached to the underlying basement, are in the hanging wall of a northwest dipping shear zone. Based on the variations in metamorphic grade and the 40Ar/ 39Ar

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Matthew J.; Ottoni, Elizabeth; Ishiyama, Noboru

Elucidation of activation mechanisms governing protein fusions is essential for therapeutic development. MLL undergoes rearrangement with numerous partners, including a recurrent translocation fusing the epigenetic regulator to a cytoplasmic RAS effector, AF6/afadin. We show here that AF6 employs a non-canonical, evolutionarily conserved α-helix to bind RAS, unique to AF6 and the classical RASSF effectors. Further, all patients with MLL-AF6 translocations express fusion proteins missing only this helix from AF6, resulting in exposure of hydrophobic residues that induce dimerization. We provide evidence that oligomerization is the dominant mechanism driving oncogenesis from rare MLL translocation partners and employ our mechanistic understanding ofmore » MLL-AF6 to examine how dimers induce leukemia. Proteomic data resolve association of dimerized MLL with gene expression modulators, and inhibiting dimerization disrupts formation of these complexes while completely abrogating leukemogenesis in mice. Oncogenic gene translocations are thus selected under pressure from protein structure/function, underscoring the complex nature of chromosomal rearrangements.« less

Invasion by nonnative brook trout in Panther Creek, Idaho: Roles of habitat quality, connectivity, and biotic resistance

Treesearch

Joseph R. Benjamin

2006-01-01

Theoretical models suggest the invasion of nonnative freshwater species is facilitated through the interaction of three factors: biotic resistance, habitat quality, and connectivity. We measured variables that represented each component to determine which were associated with small (150 mm) brook trout occurrence in Panther Creek, a tributary...

Dynamics and regulation of the southern brook trout (Salvelinus fontinalis) population in an Appalachian stream

Treesearch

Gary D. Grossman; Robert E. Ratajczak; C. Michael Wagner; J. Todd Petty

2010-01-01

1. We used information theoretic statistics [Akaike’s Information Criterion (AIC)] and regression analysis in a multiple hypothesis testing approach to assess the processes capable of explaining long-term demographic variation in a lightly exploited brook trout population in Ball Creek, NC. We sampled a 100-m-long second-order site during both spring and autumn 1991–...

Tertiary uplift of the Mt. Doonerak antiform, central Brooks Range, Alaska: Apatite fission track evidence from the Trans-Alaska Crustal Transect

USGS Publications Warehouse

O'Sullivan, P. B.; Moore, Thomas E.; Murphy, J.M.; Oldow, J.S.; Ave Lallemant, H.G.

1998-01-01

The Mt. Doonerak antiform is a northeast-trending, doubly plunging antiform located along the axial part of the central Brooks Range. This antiform is a crustal-scale duplex estimated to have a vertical displacement of ~15 km. The antiform folds the Amawk thrust, which separates relatively less displaced lower plate rocks in a window in the core of the antiform from allochthonous upper plate rocks of the Endicott Mountains allochthon. Because regional geological relations indicate that displacement on the Amawk thrust occurred between early Neocomian and early Albian time, uplift of the antiform is post-early Neocomian in age.Zircon fission-track data from the Mt. Doonerak antiform suggest -8-12 km of vertical denudation has occurred within the antiform region since -70-65 Ma. whereas apatite fission-track data indicate the antiform has experienced a minimum of -46 km of denudation since late Oligocene time. Following rapid denudation at -24 + 3 Ma, the rocks have experienced continued denudation to present surface conditions at a slower rate.We conclude from the relative relations and timing that the Mt. Doonerak duplex was constructed in part during the late Oligocene by reactivation of an older duplex formed during the latest Cretaceous to Paleocene. Deformation and uplift of Oligocene age for the axial part of the Brooks Range orogen is anomalously young, but it is the same age as the youngest episode of north-vergent contractional uplift in the northeastern Brooks Range. Because the Mt. Doonerak antiform displays structural characteristics similar to those of antiforms in the northeastern Brooks Range and because both regions experienced simultaneous rapid denudation, we suggest that the Mt. Doonerak antiform formed in response to an episode of contractional deformation that affected both areas in the late Oligocene.

The AFS Volunteer Resources Study: Summary of Findings from Australia.

ERIC Educational Resources Information Center

Walsh, Desmond; And Others

The American Field Service (AFS) has 3,500 volunteers throughout Australia. Local chapters recruit potential host families and participants. Host families are recruited actively and selectively while volunteers are recruited largely through AFS presentations at schools, through friends, and by returning volunteers. Due to a high level of demand…

Maternal genetic effects on adaptive divergence between anadromous and resident brook charr during early life history.

PubMed

Perry, G M L; Audet, C; Bernatchez, L

2005-09-01

The importance of directional selection relative to neutral evolution may be determined by comparing quantitative genetic variation in phenotype (Q(ST)) to variation at neutral molecular markers (F(ST)). Quantitative divergence between salmonid life history types is often considerable, but ontogenetic changes in the significance of major sources of genetic variance during post-hatch development suggest that selective differentiation varies by developmental stage. In this study, we tested the hypothesis that maternal genetic differentiation between anadromous and resident brook charr (Salvelinus fontinalis Mitchill) populations for early quantitative traits (embryonic size/growth, survival, egg number and developmental time) would be greater than neutral genetic differentiation, but that the maternal genetic basis for differentiation would be higher for pre-resorption traits than post-resorption traits. Quantitative genetic divergence between anadromous (seawater migratory) and resident Laval River (Québec) brook charr based on maternal genetic variance was high (Q(ST) > 0.4) for embryonic length, yolk sac volume, embryonic growth rate and time to first response to feeding relative to neutral genetic differentiation [F(ST) = 0.153 (0.071-0.214)], with anadromous females having positive genetic coefficients for all of the above characters. However, Q(ST) was essentially zero for all traits post-resorption of the yolk sac. Our results indicate that the observed divergence between resident and anadromous brook charr has been driven by directional selection, and may therefore be adaptive. Moreover, they provide among the first evidence that the relative importance of selective differentiation may be highly context-specific, and varies by genetic contributions to phenotype by parental sex at specific points in offspring ontogeny. This in turn suggests that interpretations of Q(ST)-F(ST) comparisons may be improved by considering the structure of quantitative genetic

Organic Compounds in Running Gutter Brook Water Used for Public Supply near Hatfield, Massachusetts, 2003-05

USGS Publications Warehouse

Brown, Craig J.; Trombley, Thomas J.

2009-01-01

The 258 organic compounds studied in this U.S. Geological Survey (USGS) assessment generally are man-made, including pesticides, solvents, gasoline hydrocarbons, personal-care and domestic-use products, and pavement and combustion-derived compounds. Of these 258 compounds, 26 (about 10 percent) were detected at least once among the 31 samples collected approximately monthly during 2003-05 at the intake of a flowthrough reservoir on Running Gutter Brook in Massachusetts, one of several community water systems on tributaries of the Connecticut River. About 81 percent of the watershed is forested, 14 percent is agricultural land, and 5 percent is urban land. In most source-water samples collected at Running Gutter Brook, fewer compounds were detected and their concentrations were low (less than 0.1 micrograms per liter) when compared with compounds detected at other stream sites across the country that drain watersheds that have a larger percentage of agricultural and urban areas. The relatively few compounds detected at low concentrations reflect the largely undeveloped land use at Running Gutter Brook. Despite the absence of wastewater discharge points on the stream, however, the compounds that were detected could indicate different sources and uses (point sources, precipitation, domestic, and agricultural) and different pathways to drinking-water supplies (overland runoff, groundwater discharge, leaking of treated water from distribution lines, and formation during treatment). Six of the 10 compounds detected most commonly (in at least 20 percent of the samples) in source water also were detected commonly in finished water (after treatment but prior to distribution). Concentrations in source and finished water generally were below 0.1 micrograms per liter and always less than humanhealth benchmarks, which are available for about one-half of the compounds detected. On the basis of this screening-level assessment, adverse effects to human health are expected to be

National Program for Inspection of Non-Federal Dams. Palmer Brook Dam MA 00205, Connecticut River Basin, Becket, Massachusetts. Phase I Inspection Report.

DTIC Science & Technology

1981-03-01

DAMS PALMER BROOK DAM LOCATION MAP 2010 OpO 9 1Q00 20-0 AND DRAINAGE AREA DRAWN ICHECKED APPROVED SCALE AS SHOWN SCALE IN FEET L L R D B W F J. K. DATE...BROOK DAM EXHIBIT C-2-DIKE GUIDE TO PHOTOGRAPHS DRAWN iCHECKED JAPPOVED ,SCALE: 1.1K 5F0FT. L.L.R. D.B.W. F. J.K. JDATE: 2/8I PAGE C-2 ,it PRODUJCED A...ooo opo2000FLOOD IMPACT AREA P SALEIN EETDRAWN ICHECKED IAPPROVED ISCALE AS SHOWN SCALE__________IN______________ L. L. R. D. B. W. IF J. K. JDATE 2

Identification of a barrier height threshold where brook trout population genetic diversity, differentiation, and relatedness are affected

Treesearch

Anne Timm; Eric Hallerman; Andy Dolloff; Mark Hudy; Randall Kolka

2016-01-01

The overall goal of the study was to evaluate effects of landscape features, barriers, on Brook Trout Salvelinus fontinalis population genetics and to identify a potential barrier height threshold where genetic diversity was reduced upstream of the barrier and differentiation and relatedness increase. We screened variation at eight...

Stream acidification and mortality of brook trout (Salvelinus fontinalis) in response to timber harvest in Catskill Mountain watersheds, New York, USA

USGS Publications Warehouse

Baldigo, Barry P.; Murdoch, Peter S.; Burns, Douglas A.

2005-01-01

Effects of clear-cut and timber-stand improvement (TSI) harvests on water chemistry and mortality of caged brook trout (Salvelinus fontinalis) were evaluated in a study of three Catskill Mountain streams, 1994-2000. Harvests removed 73% of tree basal area (BA) from a clearcut subbasin, 5% BA from a TSI subbasin, and 14% BA at a site below the confluence of both streams. A fourth nonharvested site served as a control. Water quality and trout mortality were affected only in the clearcut stream. Acidity and concentrations of nitrate and inorganic monomeric aluminum (Alim) increased sharply during high flows after the first growing season (fall 1997). Acid-Alim episodes were severe during this period and decreased steadily in magnitude and duration thereafter. All trout at this site died within 7 days during spring 1998 and 85% died during spring 1999. Only background mortality was observed in other years at this site and at the other three sites during all tests. The absence of mortality in TSI watersheds indicates that limited harvests should not harm brook trout populations in acid-sensitive streams. Effects of tree harvests on fish communities are of concern, however, because many stream-dwelling species are more sensitive to acidified waters than brook trout. ?? 2005 NRC.

Effect of aldosterone on cochlear Af9 expression and hearing in guinea pig.

PubMed

Qin, Li; Zhang, Biyun; Wang, Qianying; Li, Duanchao; Luo, Xiaoli; Zhong, Shixun

2017-09-01

Af9 protein in cochlea may be closely related to endolymph regulation by aldosterone and thus may be involved in pathogenesis of endolymphatic hydrops (EH). EH is the pathological characteristic of Ménière's disease (MD). Aldosterone could induce EH, but its relationship with MD is still controversial. The aim of the present study is to investigate the Af9 protein expression in guinea pig cochlea and regulation of Af9 expression and cochlear function by aldosterone. The role of Af9 in pathogenesis of EH is discussed. Thirty guinea pigs were randomly divided into two groups. The treatment group was intraperitoneally injected with aldosterone 0.1 mg/kg/d for 5 days, while the control group was done with saline. Hearing and histomorphology of cochlea were examined. In addition, expression of Af9 protein was studied. The hearing threshold of the treatment group was increased. EH was induced in 73% of guinea pigs in the treatment group, and no EH was found in the control group. Af9 protein was found in spiral limbus, stria vascularis, Reissner's membrane, organ of Corti and spiral ganglion in both groups. Af9 expression in cochlea decreased significantly at protein level after treatment by aldosterone.

Changes in native bull trout and non-native brook trout distributions in the upper Powder River basin after 20 years, relationships to water temperature and implications of climate change

Treesearch

Philip J. Howell

2017-01-01

Many bull trout populations have declined from non-native brook trout introductions, habitat changes (e.g. water temperature) and other factors. We systematically sampled the distribution of bull trout and brook trout in the upper Powder River basin in Oregon in the 1990s and resampled it in 2013–2015, examined temperature differences in the habitats of the two species...

Air Force Global Weather Central System Architecture Study. Final System/Subsystem Summary Report. Volume 8. System Specification

DTIC Science & Technology

1976-03-01

Service , CSE, Scott AFB, IL 62225. aws, usaf ltr dtd 8 jul 1976 >- a. CD SYSTEM DEVELOPMENT CORPORATION 1/ 2500 Colorado Avenue Santa Monica...Government Agen-TfAf* 17 MAR 1976 cies only. Other requests for this document ’-^ must be referred to Air Weather Service /CSi^,, Scott Air Force...Air Force Communica- tions Service must be clear’y defined. The appropriate Air Force Conmunications Service Agency should be responsible for the

High-resolution geophysical data collected within Red Brook Harbor, Buzzards Bay, Massachusetts, in 2009

USGS Publications Warehouse

Turecek, Aaron M.; Danforth, William W.; Baldwin, Wayne E.; Barnhardt, Walter A.

2012-01-01

The U.S. Geological Survey conducted a high-resolution geophysical survey within Red Brook Harbor, Massachusetts, from September 28 through November 17, 2009. Red Brook Harbor is located on the eastern edge of Buzzards Bay, south of the Cape Cod Canal. The survey area was approximately 7 square kilometers, with depths ranging from 0 to approximately 10 meters. Data were collected aboard the U.S. Geological Survey Research Vessel Rafael. The research vessel was equipped with a 234-kilohertz interferometric sonar system to collect bathymetry and backscatter data, a dual frequency (3.5- and 200-kilohertz) compression high-intensity radar pulse seismic reflection profiler to collect subbottom data, a sound velocity profiler to acquire speed of sound within the water column, and a sea floor sampling device to collect sediment samples, video, and photographs. The survey was part of an ongoing cooperative effort between the U.S. Geological Survey and the Massachusetts Office of Coastal Zone Management to map the geology of the Massachusetts inner continental shelf. In addition to inclusion within the cooperative geologic mapping effort, these data will be used to assess the shallow-water mapping capability of the geophysical systems deployed for this project, with an emphasis on identifying resolution benchmarks for the interferometric sonar system.

Feeding ecology of Brook Silverside, Golden Shiner, and Subyearling Pumpkinseed in a Lake Ontario embayment

USGS Publications Warehouse

Johnson, James H.; Chalupnicki, Marc; Abbett, Ross; Diaz, Avriel R; Nack, Christopher C

2017-01-01

Fish feeding ecology has been shown to vary over a 24-h period in terms of the prey consumed and feeding intensity. Consequently, in order to best determine the interspecific feeding associations within a fish community, examination of the diet at multiple times over a 24-h period is often necessary. We examined the diel feeding ecology of three fish species that were numerically dominant in a Lake Ontario embayment during summer. The diet of each of the three species, young-of-year Pumpkinseed Lepomis gibbosus, Golden Shiner Notemigonus crysoleucas, and Brook Silverside Labidesthes sicculus, was distinct with no significant overlap in diet composition occurring within any of the 4-h time intervals. The diet composition of each species suggested that Brook Silverside were feeding at the surface (terrestrial invertebrates and aquatic surface dwelling hemipterans), whereas young-of-year Pumpkinseed (amphipods) and Golden Shiner (tipulids) were feeding on different benthic prey. Differences in feeding periodicity were most pronounced for young-of-year Pumpkinseed. Our findings provide valuable insights on interspecific feeding associations among these three fish species during summer in a Lake Ontario embayment.

GLA-AF, an emulsion-free vaccine adjuvant for pandemic influenza.

PubMed

Clegg, Christopher H; Roque, Richard; Perrone, Lucy A; Rininger, Joseph A; Bowen, Richard; Reed, Steven G

2014-01-01

The ongoing threat from Influenza necessitates the development of new vaccine and adjuvant technologies that can maximize vaccine immunogenicity, shorten production cycles, and increase global vaccine supply. Currently, the most successful adjuvants for Influenza vaccines are squalene-based oil-in-water emulsions. These adjuvants enhance seroprotective antibody titers to homologous and heterologous strains of virus, and augment a significant dose sparing activity that could improve vaccine manufacturing capacity. As an alternative to an emulsion, we tested a simple lipid-based aqueous formulation containing a synthetic TLR4 ligand (GLA-AF) for its ability to enhance protection against H5N1 infection. GLA-AF was very effective in adjuvanting recombinant H5 hemagglutinin antigen (rH5) in mice and was as potent as the stable emulsion, SE. Both adjuvants induced similar antibody titers using a sub-microgram dose of rH5, and both conferred complete protection against a highly pathogenic H5N1 challenge. However, GLA-AF was the superior adjuvant in ferrets. GLA-AF stimulated a broader antibody response than SE after both the prime and boost immunization with rH5, and ferrets were better protected against homologous and heterologous strains of H5N1 virus. Thus, GLA-AF is a potent emulsion-free adjuvant that warrants consideration for pandemic influenza vaccine development.

Identification of larval Pacific lampreys (Lampetra tridentata), river lampreys (L. ayresi), and western brook lampreys (L. richardsoni) and thermal requirements of early life history stages of lampreys. Annual report 2002-2003

USGS Publications Warehouse

Meeuwig, M.H.; Bayer, J.M.; Seelye, J.G.; Reiche, R.A.

2003-01-01

Two fundamental aspects of lamprey biology were examined to provide tools for population assessment and determination of critical habitat needs of Columbia River Basin (CRB) lampreys (the Pacific lamprey, Lampetra tridentata, and the western brook lamprey, L. richardsoni). We evaluated the usefulness of current diagnostic characteristics for identification of larval lampreys (i.e., pigment patterns) and collected material for development of meristic and morphometric descriptions of early life stage CRB lampreys, and we determined the effects of temperature on survival and development of early life stage CRB lampreys. Thirty-one larval lampreys were collected from locations throughout the CRB and transported to the Columbia River Research Laboratory. Lampreys were sampled at six-week intervals at which time they were identified to the species level based on current diagnostic characteristics. Sampling was repeated until lampreys metamorphosed, at which time species identification was validated based on dentition, or until they died, at which time they were preserved for genetic examination. These lampreys were sampled 30 times with two individuals metamorphosing, both of which were consistently identified, and subsequently validated, as Pacific lampreys. Of the remaining lampreys, only one was inconsistently identified (Pacific lamprey in 83% of the sampling events and western brook lamprey in 17% of the sampling events). These data suggest that pigmentation patterns do not change appreciably through time. In 2001 and 2002 we artificially spawned Pacific and western brook lampreys in the laboratory to provide material for meristic and morphometric descriptions. We collected, digitized, preserved, and measured the mean chorion diameter of Pacific and western brook lamprey embryos. Embryos ranged in development from 1 d post fertilization to just prior to hatch, and were incubated at 14 C. Mean chorion diameter was greater and more variable for Pacific lampreys (mean

The Laser Teaching Center at Stony Brook

NASA Astrophysics Data System (ADS)

Metcalf, Harold

2010-03-01

Stony Brook's Laser Teaching Center was built more than ten years ago to serve a clientele ranging from high school (HS) students to graduate students. Its construction in a formerly open hallway area was financed by donations from private corporations and foundations, and it was equipped with similar contributions. It provides a working area for laser and optics-related projects, both individual and group. Its daily operations are overseen by a highly-dedicated Ph.D. who is a department employee. It is populated by HS students doing science fair related research, including the major national contests (in which we have many finalists and semifinalists), undergraduates doing extra-credit course projects and other kinds of research activities, graduate students in a special course called ``Optics Rotation,'' and many others who come to use its facilities. All of its denizens benefit enormously by occasional prestigious visitors. Students are drawn from among our undergraduates and graduate students, NSF's WISE program, special HS summer programs, and direct application from the outside. We have an excellent record of placing our HS students in the highest ranking colleges.

Levels-of-growing-stock cooperative study in Douglas-fir: report no. 18--Rocky Brook, 1963-2006.

Treesearch

Robert O. Curtis; David D. Marshall

2009-01-01

This report documents the history and results of the Rocky Brook installation of the cooperative levels-of-growing-stock (LOGS) study in Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco), over the 41-year period 1965 to 2006. This 1938 plantation is one of the two site-IV installations among the nine installations in the study. Much public...

The Stories of Nico and Brooke Revisited: Toward a Cross-Disciplinary Dialogue about Teaching and Learning

ERIC Educational Resources Information Center

Immordino-Yang, Mary Helen

2008-01-01

In "A tale of two cases: Lessons for education from the study of two boys living with half their brains" (M. H. Immordino-Yang, 2007), I showed that Nico (missing his right cerebral hemisphere) and Brooke (missing his left) had compensated for basic neuropsychological skills to previously unexpected degrees and argued that the ways they had…

Linking water age and solute dynamics in streamflow at the Hubbard Brook Experimental Forest, NH, USA

Treesearch

Paolo Benettin; Scott W. Bailey; John L. Campbell; Mark B. Green; Andrea Rinaldo; Gene E. Likens; Kevin J. McGuire; Gianluca Botter

2015-01-01

We combine experimental and modeling results from a headwater catchment at the Hubbard Brook Experimental Forest (HBEF), New Hampshire, USA, to explore the link between stream solute dynamics and water age. A theoretical framework based on water age dynamics, which represents a general basis for characterizing solute transport at the catchment scale, is here applied to...

Elevation dependent sensitivity of northern hardwoods to Ca addition at Hubbard Brook Experimental Forest, NH USA

Treesearch

Rakesh Minocha; Stephanie Long; Palaniswamy Thangavel; Subhash C. Minocha; Christopher Eagar; Charles T. Driscoll

2010-01-01

Acidic deposition has caused a depletion of calcium (Ca) in the northeastern forest soils. Wollastonite (Ca silicate) was added to watershed 1 (WS1) at the Hubbard Brook Experimental Forest (HBEF) in 1999 to evaluate its effects on various functions of the HBEF ecosystem. The effects of Ca addition on foliar soluble (extractable in 5% HClO4) ions...

Ice processes affect habitat use and movements of adult cutthroat trout and brook trout in a Wyoming foothills stream

USGS Publications Warehouse

Lindstrom, J.W.; Hubert, W.A.

2004-01-01

Habitat use and movements of 25 adult cutthroat trout Oncorhynchus clarkii and 25 adult brook trout Salvelinus fontinalis from fall through winter 2002-2003 were assessed by means of radiotelemetry in a 7-km reach of a Rocky Mountains foothills stream. Temporal dynamics of winter habitat conditions were evaluated by regularly measuring the features of 30 pools and 5 beaver Castor canadensis ponds in the study reach. Groundwater inputs at three locations raised mean daily water temperatures in the stream channel during winter to 0.2-0.6??C and kept at least 250 m of the downstream channel free of ice, but the lack of surface ice further downstream led to the occurrence of frazil ice and anchor ice in pools and unstable habitat conditions for trout. Pools in segments that were not affected by groundwater inputs and beaver ponds tended to be stable and snow accumulated on the surface ice. Pools throughout the study reach tended to become more stable as snow accumulated. Both cutthroat trout and brook trout selected beaver ponds as winter progressed but tended to use lateral scour pools in proportion to their availability. Tagged fish not in beaver ponds selected lateral scour pools that were deeper than average and stable during winter. Movement frequencies by tagged fish decreased from fall through winter, but some individuals of both species moved during winter. Ice processes affected both the habitat use and movement patterns of cutthroat trout and brook trout in this foothills stream.

Rivaroxaban in patients with atrial fibrillation: from ROCKET AF to everyday practice.

PubMed

Barón-Esquivias, Gonzalo; Marín, Francisco; Sanmartín Fernandez, Marcelo

2017-05-01

Registries and non-interventional studies offer relevant and complementary information to clinical trials, since they have a high external validity. Areas covered: The information regarding the efficacy and safety of rivaroxaban compared with warfarin, or rivaroxaban alone in clinical practice was reviewed in this manuscript. For this purpose, a search on MEDLINE and EMBASE databases was performed. The MEDLINE and EMBASE search included both medical subject headings (MeSH) and keywords including: atrial fibrillation (AF) OR warfarin OR clinical practice OR ROCKET AF AND rivaroxaban. Case reports were not considered. Expert commentary: In ROCKET AF, rivaroxaban was at least as effective as warfarin for the prevention of stroke in patients with nonvalvular AF at high risk of stroke, but, importantly, with a lesser risk of intracranial, critical and fatal bleedings. A number of observational comparative and non-comparative studies, with more than 60,000 patients included treated with rivaroxaban, have analyzed the efficacy and safety of rivaroxaban in real-life patients with AF in different clinical settings. These studies have shown that in clinical practice, rates of stroke and major bleeding were consistently lower than those reported in ROCKET AF, likely due to the lower thromboembolic and bleeding risk observed in these patients.

GPIM AF-M315E Propulsion System

NASA Technical Reports Server (NTRS)

Spores, Ronald A.; Masse, Robert; Kimbrel, Scott; McLean, Chris

2014-01-01

The NASA Space Technology mission Directorate's (STMD) Green Propellant Infusion Mission (GPIM) Technology Demonstration Mission (TDM) will demonstrate an operational AF-M315E green propellant propulsion system. Aerojet-Rocketdyne is responsible for the development of the propulsion system payload. This paper statuses the propulsion system module development, including thruster design and system design; Initial test results for the 1N engineering model thruster are presented. The culmination of this program will be high-performance, green AF-M315E propulsion system technology at TRL 7+, with components demonstrated to TRL 9, ready for direct infusion to a wide range of applications for the space user community.

Thromboembolic event rate in paroxysmal and persistent atrial fibrillation: Data from the GISSI-AF trial

PubMed Central

2013-01-01

Background Few data on the thromboembolic (TE) risk of paroxysmal and persistent atrial fibrillation (AF) are available. This study aimed to assess the incidence of TE events in paroxysmal and persistent AF. Methods We performed a subset post hoc analysis of 771 patients with paroxysmal and 463 with persistent AF enrolled in the multicenter, prospective, randomized, double-blind, placebo-controlled GISSI-AF trial - comparing the efficacy of valsartan versus placebo in preventing AF recurrences – where the choice of antithrombotic treatment was left to the judgment of the referring physician. TE and major outcome events were centrally validated. AF recurrences were detected by frequent clinic visits and a transtelephonic monitoring device with weekly and symptomatic transmissions. Results Eighty-five percent of patients had a history of hypertension, and the 7.7% had heart failure, left ventricular dysfunction, or both. The mean CHADS2 score was 1.41±0.84. TE and major bleeding events were observed at a low incidence among the overall population at 1-year follow-up (0.97% and 0.81%, respectively). The univariate and multivariable analyses revealed no statistically significant differences in the incidence of TE, major bleeding events or mortality in paroxysmal and persistent AF patients. TE events were more common among women than men (p=0.02). The follow-up examination showed under- or overtreatment with warfarin in many patients, according to guideline suggestions. Warfarin was more frequently prescribed to patients with persistent AF (p<0.0001) and patients with AF recurrences (p<0.0001). AF recurrences were noninvasively detected in 632 (51.2%) patients. In patients without AF recurrences, the TE event rate was 0.5% versus 1.74%, 1.28%, and 1.18% for those with only symptomatic, only asymptomatic or both symptomatic and asymptomatic AF recurrences, respectively, but the difference was not statistically significant, even after adjusting for warfarin treatment

Brown bear response to elevated viewing structures at Brooks River, Alaska

USGS Publications Warehouse

DeBruyn, T.D.; Smith, T.S.; Proffitt, K.; Partridge, S.; Drummer, T.D.

2004-01-01

The increasing popularity of brown bear (Ursus arctos) viewing at Brooks River in Katmai National Park, Alaska has resulted in overcrowded facilities, increasing bear-human conflicts, displacement of bears from important habitats, and degradation of cultural resources. To partially address these issues, the National Park Service (NPS) constructed a 300-m-long elevated boardwalk with interconnected viewing platforms in August 2000. To determine what effects the new structures might have on individual bears, we observed bear movements and behaviors before and after construction. We used direct observations and motion-detection cameras to construct temporal-spatial profiles of bear activity. Although bear numbers were similar (59 bears in 2000 and 56 bears in 2001) and bear activity within the greater Brooks River area did not differ (P = 0.62, n = 29) between the 2 years of this study, trail crossings in the vicinity of the new structures decreased 78% (7,436 crossings in 2000 and 1,646 crossings in 2001; ??2 = 762, df = 14, P < 0.001). Bear temporal use of the boardwalk area changed such that when human use was highest, bear use was proportionally lower in the post- versus pre-construction phase (??2 = 34, df = 3, P < 0.005). Of 123 direct observations of bears approaching to pass beneath the structures, only 19.5% rerouted or avoided crossing under the structures. Bears' responses to the new structures were influenced by the behavior of visitors upon the structures. Potential management tools to minimize impacts of these structures on bears include enhanced public education regarding visitor conduct on the boardwalk, as well as visitor management and monitoring.

78 FR 8582 - Final Environmental Impact Statement for Brooks River Visitor Access for Katmai National Park and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-06

... River floating bridge and sites to relocate the existing Naknek Lake barge landing area at the mouth of... barge landing site would be located approximately 200 feet south of the mouth of the Brooks River. A new... new Naknek Lake barge landing site. Alternative 4 (NPS Preferred Alternative): This alternative...

What Do Facts Have to Do with It? Exploring Instructional Emphasis in Stony Brook News Literacy Curriculum

ERIC Educational Resources Information Center

Fleming, Jennifer

2015-01-01

An analytic matrix comprised of multiple media literacy teaching and learning principles is conceptualized to examine a model of news literacy developed by journalism educators at Stony Brook University. The multidimensional analysis indicates that news literacy instructors focus on teaching students how to question and assess the veracity of news…

Variation in chemistry of stream water and bulk deposition across the Hubbard Brook Valley, New Hampshire, USA

Treesearch

Gene E. Likens; Donald C. Buso; James W. Hornbeck

2002-01-01

Chemistry and volume of precipitation and stream water have been measured in south-facing watersheds of the Hubbard Brook Experimental Forest (HBEF), continuously for 37 years. These long-term data have provided important insights into the bio-geochemistry of these watershed ecosystems and the region (e.g. LIKENS & BORMANN 1995).

Action of AF64A on rat brain muscarinic receptors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eva, C.; Costa, E.

ICV administration of compound AF64A (ethylcholine mustard aziridium ion) induces a long-term selective cholinergic hypofunction; however, it does not modify the characteristics of muscarinic receptors. In brain muscarinic receptor activation can either stimulate phosphoinositide turnover or inhibit adenylate cyclase. ICV infusion of AF64A (5 nmol/side/2.5 ..mu..l) reduced the hippocampal ACh content 10 or 30 days after the treatment to 75% of the control values. Under these conditions neither in the striatum nor in the frontal cortex ACh levels were decreased. The carbachol dose-dependent stimulation in hippocampal slices differed from that observed in control rats. The carbachol efficacy was increased butmore » its potency was unchanged by AF64A. In contrast, ICV administration of AF64A failed to alter the oxotremorine efficacy or potency in inhibiting the forskolin stimulated adenylate cyclase in rat hippocampal membranes. These results suggest the two transducer systems coupled to muscarinic receptors may be differentially regulatable by cholinergic input.« less

Clinical presentation, management, and outcomes in the Indian Heart Rhythm Society-Atrial Fibrillation (IHRS-AF) registry.

PubMed

Vora, A; Kapoor, A; Nair, M; Lokhandwala, Y; Narsimhan, C; Ravikishore, A G; Dwivedi, S K; Namboodiri, N; Hygriv, R; Saxena, A; Nabar, A; Garg, S; Bardoloi, N; Yadav, R; Nambiar, A; Pandurangi, U; Jhala, D; Naik, A; Nagmallesh; Rajagopal, S; Selvaraj, R; Arora, V; Thachil, A; Thomas, J; Panicker, G

A national atrial fibrillation (AF) registry was conducted under the aegis of the Indian Heart Rhythm Society (IHRS), to capture epidemiological data-type of AF, clinical presentation and comorbidities, current treatment practices, and 1-year follow-up outcomes. A total of 1537 patients were enrolled from 24 sites in India in the IHRS-AF registry from July 2011 to August 2012. Their baseline characteristics and follow-up data were recorded in case report forms and subsequently analyzed. The average age of Indian AF patients was 54.7 years. There was a marginal female preponderance - 51.5% females and 48.5% males. At baseline, 20.4% had paroxysmal AF; 33% had persistent AF; 35.1% had permanent AF and 11% had first AF episode. At one-year follow-up, 45.6% patients had permanent AF. Rheumatic valvular heart disease (RHD) was present in 47.6% of patients. Hypertension, heart failure, coronary artery disease, and diabetes were seen in 31.4%, 18.7%, 16.2%, and 16.1%, respectively. Rate control was the strategy used in 75.2% patients, digoxin and beta-blockers being the most frequently prescribed rate-control drugs. Oral anticoagulation (OAC) drugs were used in 70% of patients. The annual mortality was 6.5%, hospitalization 8%, and incidence of stroke 1%. In India, AF patients are younger and RHD is still the most frequent etiology. Almost two-third of the patients have persistent/permanent AF. At one-year follow-up, there is a significant mortality and morbidity in AF patients in India. Copyright © 2016. Published by Elsevier B.V.

The Bcr Kinase Downregulates Ras Signaling by Phosphorylating AF-6 and Binding to Its PDZ Domain

PubMed Central

Radziwill, G.; Erdmann, R. A.; Margelisch, U.; Moelling, K.

2003-01-01

The protein kinase Bcr is a negative regulator of cell proliferation and oncogenic transformation. We identified Bcr as a ligand for the PDZ domain of the cell junction and Ras-interacting protein AF-6. The Bcr kinase phosphorylates AF-6, which subsequently allows efficient binding of Bcr to AF-6, showing that the Bcr kinase is a regulator of the PDZ domain-ligand interaction. Bcr and AF-6 colocalize in epithelial cells at the plasma membrane. In addition, Bcr, AF-6, and Ras form a trimeric complex. Bcr increases the affinity of AF-6 to Ras, and a mutant of AF-6 that lacks a specific phosphorylation site for Bcr shows a reduced binding to Ras. Wild-type Bcr, but not Bcr mutants defective in binding to AF-6, interferes with the Ras-dependent stimulation of the Raf/MEK/ERK pathway. Since AF-6 binds to Bcr via its PDZ domain and to Ras via its Ras-binding domain, we propose that AF-6 functions as a scaffold-like protein that links Bcr and Ras to cellular junctions. We suggest that this trimeric complex is involved in downregulation of Ras-mediated signaling at sites of cell-cell contact to maintain cells in a nonproliferating state. PMID:12808105

Progress in radar snow research. [Brookings, South Dakota

NASA Technical Reports Server (NTRS)

Stiles, W. H.; Ulaby, F. T.; Fung, A. K.; Aslam, A.

1981-01-01

Multifrequency measurements of the radar backscatter from snow-covered terrain were made at several sites in Brookings, South Dakota, during the month of March of 1979. The data are used to examine the response of the scattering coefficient to the following parameters: (1) snow surface roughness, (2) snow liquid water content, and (3) snow water equivalent. The results indicate that the scattering coefficient is insensitive to snow surface roughness if the snow is drv. For wet snow, however, surface roughness can have a strong influence on the magnitude of the scattering coefficient. These observations confirm the results predicted by a theoretical model that describes the snow as a volume of Rayleig scatterers, bounded by a Gaussian random surface. In addition, empirical models were developed to relate the scattering coefficient to snow liquid water content and the dependence of the scattering coefficient on water equivalent was evaluated for both wet and dry snow conditions.

77 FR 37707 - Draft Environmental Impact Statement on Brooks River Visitor Access for Katmai National Park and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-22

... floating bridge and sites to relocate the existing Naknek Lake barge landing area at the mouth of the... landing site on Naknek Lake. Alternative 3: This alternative evaluates construction of a new bridge and... barge landing site would be located approximately 200 feet south of the mouth of the Brooks River. A new...

A Guide to the Estimation of the Hazard Presented by Chemicals in Human Milk.

DTIC Science & Technology

1985-11-01

Occupational and Environmental Health Laboratory Aerospace Medical Division (AFSC) Brooks Air Force Base , Texas 78235-5501 i "-_,-..,,," ,_. .,..,;.: 1...AD-RISS 651 A GUIDE TO THE ESTIMATION OF THE HZRR PRESENTED BY CHEMICALS IN HUMAN M.. (U) AIR FORCE OCCUPATIONAL ANo ENYIRONMENTAL HEALTH LAD BROOKS...illustration purposes and does not constitute endorsement or recommendation for use by the United States Air Force . Do not return this copy. Retain or

Report on the 1975 Officers’ OER Opinion Survey

DTIC Science & Technology

1977-11-01

Lt Col, USAFA U PERSONNEL RESEARCH DIVISIONN Brooks Air Force Bas, Toma 73235 R Nmn*w 1977- ’ E S 033- Approval for public raaem; disubution unffn*ed...Personnel Research Division, under project 7719, with HQ Air Force Human Resources Laboratory (AFSC), Brooks Air Force Base, Texas 78235. This report...Service (NTIS). This technical report has been reviewed and is approved for publication. LELAND D. BROKAW, Technical Director Prsonnel Research

Changes in seasonal climate outpace compensatory density-dependence in eastern brook trout

USGS Publications Warehouse

Bassar, Ronald D.; Letcher, Benjamin H.; Nislow, Keith H.; Whiteley, Andrew R.

2016-01-01

Understanding how multiple extrinsic (density-independent) factors and intrinsic (density-dependent) mechanisms influence population dynamics has become increasingly urgent in the face of rapidly changing climates. It is particularly unclear how multiple extrinsic factors with contrasting effects among seasons are related to declines in population numbers and changes in mean body size and whether there is a strong role for density-dependence. The primary goal of this study was to identify the roles of seasonal variation in climate driven environmental direct effects (mean stream flow and temperature) versus density-dependence on population size and mean body size in eastern brook trout (Salvelinus fontinalis). We use data from a 10-year capture-mark-recapture study of eastern brook trout in four streams in Western Massachusetts, USA to parameterize a discrete-time population projection model. The model integrates matrix modeling techniques used to characterize discrete population structures (age, habitat type and season) with integral projection models (IPMs) that characterize demographic rates as continuous functions of organismal traits (in this case body size). Using both stochastic and deterministic analyses we show that decreases in population size are due to changes in stream flow and temperature and that these changes are larger than what can be compensated for through density-dependent responses. We also show that the declines are due mostly to increasing mean stream temperatures decreasing the survival of the youngest age class. In contrast, increases in mean body size over the same period are the result of indirect changes in density with a lesser direct role of climate-driven environmental change.

Estimation of streambed groundwater fluxes associated with coaster brook trout spawning habitat.

PubMed

Van Grinsven, Matthew; Mayer, Alex; Huckins, Casey

2012-01-01

We hypothesized that the spatial distribution of groundwater inflows through river bottom sediments is a critical factor associated with the distribution of coaster brook trout (a life history variant of Salvelinus fontinalis) spawning redds. An 80-m reach of the Salmon Trout River, in the Huron Mountains of the upper peninsula of Michigan, was selected to test the hypothesis based on long-term documentation of coaster brook trout spawning at this site. A monitoring well system consisting of 22 wells was installed in the riverbed to measure surface and subsurface temperatures over a 13-month period. The array of monitoring wells was positioned to span areas where spawning has and has not been observed. Over 200,000 total temperature measurements were collected from five depths within each monitoring well. Temperatures in the substrate beneath the spawning area were generally less variable than river temperatures, whereas temperatures under the nonspawning area were generally more variable and closely tracked temporal variations in river temperatures. Temperature data were inverted to obtain subsurface groundwater velocities using a numerical approximation of the heat transfer equation. Approximately 45,000 estimates of groundwater velocities were obtained. Estimated groundwater velocities in the spawning area were primarily in the upward direction and were generally greater in magnitude than velocities in the nonspawning area. Both the temperature and velocity results confirm the hypothesis that spawning sites correspond to areas of significant groundwater flux into the river bed. © 2011, The Author(s). Ground Water © 2011, National Ground Water Association.

Atrial Fibrillation Management Strategies in Routine Clinical Practice: Insights from the International RealiseAF Survey

PubMed Central

Chiang, Chern-En; Naditch-Brûlé, Lisa; Brette, Sandrine; Silva-Cardoso, José; Gamra, Habib; Murin, Jan; Zharinov, Oleg J.; Steg, Philippe Gabriel

2016-01-01

Background Atrial fibrillation (AF) can be managed with rhythm- or rate-control strategies. There are few data from routine clinical practice on the frequency with which each strategy is used and their correlates in terms of patients’ clinical characteristics, AF control, and symptom burden. Methods RealiseAF was an international, cross-sectional, observational survey of 11,198 patients with AF. The aim of this analysis was to describe patient profiles and symptoms according to the AF management strategy used. A multivariate logistic regression identified factors associated with AF management strategy at the end of the visit. Results Among 10,497 eligible patients, 53.7% used a rate-control strategy, compared with 34.5% who used a rhythm-control strategy. In 11.8% of patients, no clear strategy was stated. The proportion of patients with AF-related symptoms (EHRA Class > = II) was 78.1% (n = 4396/5630) for those using a rate-control strategy vs. 67.8% for those using a rhythm-control strategy (p<0.001). Multivariate logistic regression analysis revealed that age <75 years or the paroxysmal or persistent form of AF favored the choice of a rhythm-control strategy. A change in strategy was infrequent, even in patients with European Heart Rhythm Association (EHRA) Class > = II. Conclusions In the RealiseAF routine clinical practice survey, rate control was more commonly used than rhythm control, and a change in strategy was uncommon, even in symptomatic patients. In almost 12% of patients, no clear strategy was stated. Physician awareness regarding optimal management strategies for AF may be improved. PMID:26800084

What if the Hubbard Brook weirs had been built somewhere else? Spatial uncertainty in the application of catchment budgets

NASA Astrophysics Data System (ADS)

Bailey, S. W.

2016-12-01

Nine catchments are gaged at Hubbard Brook Experimental Forest, Woodstock, NH, USA, with weirs installed on adjacent first-order streams. These catchments have been used as unit ecosystems for analysis of chemical budgets, including evaluation of long term trends and response to disturbance. This study examines uncertainty in the representativeness of these budgets to other nearby catchments, or as representatives of the broader northern hardwood ecosystem, depending on choice of location of the stream gaging station. Within forested northern hardwood catchments across the Hubbard Brook region, there is relatively little spatial variation in amount or chemistry of precipitation inputs or in amount of streamwater outputs. For example, runoff per unit catchment area varies by less than 10% at gaging stations on first to sixth order streams. In contrast, concentrations of major solutes vary by an order of magnitude or more across stream sampling sites, with a similar range in concentrations seen within individual first order catchments as seen across the third order Hubbard Brook valley or across the White Mountain region. These spatial variations in stream chemistry are temporally persistent across a range of flow conditions. Thus first order catchment budgets vary greatly depending on very local variations in stream chemistry driven by choice of the site to develop a stream gage. For example, carbon output in dissolved organic matter varies by a factor of five depending on where the catchment output is defined at Watershed 3. I hypothesize that catchment outputs from first order streams are driven by spatially variable chemistry of shallow groundwater, reflecting local variations in the distribution of soils and vegetation. In contrast, spatial variability in stream chemistry decreases with stream order, hypothesized to reflect deeper groundwater inputs on larger streams, which are more regionally uniform. Thus, choice of a gaging site and definition of an ecosystem

Effects of urban development on direct runoff to East Meadow Brook, Nassau County, Long Island, New York

USGS Publications Warehouse

Seaburn, G.E.

1969-01-01

The study described in this report is concerned with the effects of intensive urban development on direct runoff to East Meadow Brook, a southward-flowing stream in central Nassau County, N.Y., during the period 1937-66. The specific objectives of the study were (a) to relate indices of urban development to increases in the volume of annual direct runoff to the stream; (b) to compare hydrograph features at different periods during the transition of the drainage basin from rural to urban conditions; and (c) to compare the rainfall-runoff relations for periods before and after urban development.Periods of housing and street construction in the drainage basin correspond to three distinct periods of increased direct runoff after the base period 1937-43-namely, 1944-51, 1952-59, and 1960-62. During each period, the average annual direct runoff increased because of an increase in the area served by storm sewers that discharged into East Meadow Brook. The amount of land served by sewers increased from about 570 acres in 1943 to about 3,600 acres in 1962, or about 530 percent. During this same period, the average annual direct runoff increased from about 920 acre-feet per year to about 3,400 acre-feet per year, or about 270 percent.The shape of direct-runoff unit hydrographs of East Meadow Brook also changed during the period of study. The average peak discharge of a 1-hour-duration unit hydrograph increased from 313 cubic feet per second, for storms in 1937-43, to 776 cubic feet per second, for storms in 1960-62, or about 2.5 times. In addition, the widths of the unit hydrographs for 1960-62 at values of 50 and 75 percent of the peak discharge were 38 and 28 percent, respectively, the comparable widths of the unit hydrographs for 1937-43.An analysis of the rainfall-runoff relations for both preurban and urban conditions indicates that the direct runoff for both periods increased with the magnitude of the storm. However, the direct runoff during a period of urbanized

Improvements In AF Ablation Outcome Will Be Based More On Technological Advancement Versus Mechanistic Understanding.

PubMed

Jiang Md, Chen-Yang; Jiang Ms, Ru-Hong

2014-01-01

Atrial fibrillation (AF) is one of the most common cardiac arrhythmias. Catheter ablation has proven more effective than antiarrhythmic drugs in preventing clinical recurrence of AF, however long-term outcome remains unsatisfactory. Ablation strategies have evolved based on progress in mechanistic understanding, and technologies have advanced continuously. This article reviews current mechanistic concepts and technological advancements in AF treatment, and summarizes their impact on improvement of AF ablation outcome.

Brief Report: Stony Brook Guidelines on the Ethics of the Care of People with Autism and Their Families

ERIC Educational Resources Information Center

Post, Stephen G.; Pomeroy, John; Keirns, Carla C.; Cover, Virginia Isaacs; Dorn, Michael Leverett; Boroson, Louis; Boroson, Florence; Coulehan, Anne; Coulehan, Jack; Covell, Kim; Kubasek, Kim; Luchsinger, Elizabeth; Nichols, Shana; Parles, James; Schreiber, Linda; Tetenbaum, Samara P.; Walsh, Rose Ann

2013-01-01

The increased prevalence of autism spectrum disorders (ASD), with associated societal and clinical impacts, calls for a broad community-based dialogue on treatment related ethical and social issues. The Stony Brook Guidelines, based on a community dialogue process with affected individuals, families and professionals, identify and discuss the…

Exchange bias mechanism in FM/FM/AF spin valve systems in the presence of random unidirectional anisotropy field at the AF interface: The role played by the interface roughness due to randomness

NASA Astrophysics Data System (ADS)

Yüksel, Yusuf

2018-05-01

We propose an atomistic model and present Monte Carlo simulation results regarding the influence of FM/AF interface structure on the hysteresis mechanism and exchange bias behavior for a spin valve type FM/FM/AF magnetic junction. We simulate perfectly flat and roughened interface structures both with uncompensated interfacial AF moments. In order to simulate rough interface effect, we introduce the concept of random exchange anisotropy field induced at the interface, and acting on the interface AF spins. Our results yield that different types of the random field distributions of anisotropy field may lead to different behavior of exchange bias.

EVALUATION OF CHROMOMYCIN A3 ASSAY IN HUMAN SPERM AFTER SIMULATED OVERNIGHT SHIPMENT

EPA Science Inventory

EVALUATION OF CHROMOMYCIN A3ASSAY IN HUMAN SPERM AFTER SIMULATED OVERNIGHT SHIPMENT.
SC Jeffay1, R Morris Buus1, LF Strader1, AF Olshan2, DP Evenson3, SD Perreault1. 1US EPA/ORD, RTP, NC;2UNC-CH, Chapel Hill, NC;3SDSU, Brookings, SD.

Semen collection kits that allow ...

Effects of dam removal on brook trout in a Wisconsin stream

USGS Publications Warehouse

Stanley, E.H.; Catalano, M.J.; Mercado-Silva, N.; Orr, C.H.

2007-01-01

Dams create barriers to fish migration and dispersal in drainage basins, and the removal of dams is often viewed as a means of increasing habitat availability and restoring migratory routes of several fish species. However, these barriers can also isolate and protect native taxa from aggressive downstream invaders. We examined fish community composition two years prior to and two years after the removal of a pair of low-head dams from Boulder Creek, Wisconsin, U.S.A. in 2003 to determine if removal of these potential barriers affected the resident population of native brook trout (Salvelinus fontinalis). Despite the presence of other taxa in the downstream reaches, and in other similar streams adjacent to the Boulder Creek (including the brown trout, Salmo trutta), no new species had colonized the Boulder Creek in the two years following dam removal. The adults catch per unit effort (CPUE) was lower and the young-of-the-year catch per unit effort (YOY CPUE) was higher in 2005 than in 2001 in all reaches, but the magnitude of these changes was substantially larger in the two dam-affected sample reaches relative to an upstream reference reach, indicating a localized effect of the removal. Total length of the adults and the YOY and the adult body condition did not vary between years or among reaches. Thus, despite changes in numbers of adults and the YOYs in some sections of the stream, the lack of new fish species invading Boulder Creek and the limited extent of population change in brook trout indicate that dam removal had a minor effect on these native salmonids in the first two years of the post-removal. Copyright ?? 2007 John Wiley & Sons, Ltd.

A Critical Role for CRM1 in Regulating HOXA Gene Transcription in CALM-AF10 Leukemias

PubMed Central

Conway, Amanda E.; Haldeman, Jonathan M.; Wechsler, Daniel S.; Lavau, Catherine P.

2014-01-01

The leukemogenic CALM-AF10 fusion protein is found in patients with immature acute myeloid and T-lymphoid malignancies. CALM-AF10 leukemias display abnormal H3K79 methylation and increased HOXA cluster gene transcription. Elevated expression of HOXA genes is critical for leukemia maintenance and progression; however, the precise mechanism by which CALM-AF10 alters HOXA gene expression is unclear. We previously determined that CALM contains a CRM1-dependent nuclear export signal (NES), which is both necessary and sufficient for CALM-AF10-mediated leukemogenesis. Here, we find that interaction of CALM-AF10 with the nuclear export receptor CRM1 is necessary for activating HOXA gene expression. We show that CRM1 localizes to HOXA loci where it recruits CALM-AF10, leading to transcriptional and epigenetic activation of HOXA genes. Genetic and pharmacological inhibition of the CALM-CRM1 interaction prevents CALM-AF10 enrichment at HOXA chromatin, resulting in immediate loss of transcription. These results provide a comprehensive mechanism by which the CALM-AF10 translocation activates the critical HOXA cluster genes. Furthermore, this report identifies a novel function of CRM1: the ability to bind chromatin and recruit the NES-containing CALM-AF10 transcription factor. PMID:25027513

Bioavailability of metals in stream food webs and hazards to brook trout (Salvelinus fontinalis) in the upper Animas River watershed, Colorado

USGS Publications Warehouse

Besser, J.M.; Brumbaugh, W.G.; May, T.W.; Church, S.E.; Kimball, B.A.

2001-01-01

The water quality, habitats, and biota of streams in the upper Animas River watershed of Colorado, USA, are affected by metal contamination associated with acid drainage. We determined metal concentrations in components of the food web of the Animas River and its tributaries - periphyton (aufwuchs), benthic invertebrates, and livers of brook trout (Salvelinus fontinalis) - and evaluated pathways of metal exposure and hazards of metal toxicity to stream biota. Concentrations of the toxic metals cadmium (Cd), copper (Cu), lead (Pb), and zinc (Zn) in periphyton, benthic invertebrates, and trout livers from one or more sites in the upper Animas River were significantly greater than those from reference sites. Periphyton from sites downstream from mixing zones of acid and neutral waters had elevated concentrations of aluminum (Al) and iron (Fe) reflecting deposition of colloidal Fe and Al oxides, and reduced algal biomass. Metal concentrations in benthic invertebrates reflected differences in feeding habits and body size among taxa, with greatest concentrations of Zn, Cu, and Cd in the small mayfly Rhithrogena, which feeds on periphyton, and greatest concentrations of Pb in the small stonefly Zapada, a detritivore. Concentrations of Zn and Pb decreased across each trophic linkage, whereas concentrations of Cu and Cd were similar across several trophic levels, suggesting that Cu and Cd were more efficiently transferred via dietary exposure. Concentrations of Cu in invertebrates and trout livers were more closely associated with impacts on trout populations and invertebrate communities than were concentrations of Zn, Cd, or Pb. Copper concentrations in livers of brook trout from the upper Animas River were substantially greater than background concentrations and approached levels associated with reduced brook trout populations in field studies and with toxic effects on other salmonids in laboratory studies. These results indicate that bioaccumulation and transfer of

Consolidating Air Force Maintenance Occupational Specialties

DTIC Science & Technology

2016-01-01

Bill Gilbert . A number of colleagues at RAND, including John Drew, Laura Baldwin, Al Robbert, and Ray Conley, provided support during this effort...Massey, James M. Masters, Raymond A. Pyles, Ricardo Sanchez, Jerry M. Sollinger, Brent Thomas, Robert S. Tripp, and Ben D. Van Roo, Analysis of the Air...MG-872-AF, 2009), Tripp et al. (Robert S. Tripp, Ronald G. McGarvey, Ben D. Van Roo, James M. Masters and Jerry M. Sollinger. A Repair Network

Detection of atrial fibrillation and flutter by a dual-chamber implantable cardioverter-defibrillator. For the Worldwide Jewel AF Investigators.

PubMed

Swerdlow, C D; Schsls, W; Dijkman, B; Jung, W; Sheth, N V; Olson, W H; Gunderson, B D

2000-02-29

To distinguish prolonged episodes of atrial fibrillation (AF) that require cardioversion from self-terminating episodes that do not, an atrial implantable cardioverter-defibrillator (ICD) must be able to detect AF continuously for extended periods. The ICD should discriminate between atrial tachycardia/flutter (AT), which may be terminated by antitachycardia pacing, and AF, which requires cardioversion. We studied 80 patients with AT/AF and ventricular arrhythmias who were treated with a new atrial/dual-chamber ICD. During a follow-up period lasting 6+/-2 months, we validated spontaneous, device-defined AT/AF episodes by stored electrograms in all patients. In 58 patients, we performed 80 Holter recordings with telemetered atrial electrograms, both to validate the continuous detection of AT/AF and to determine the sensitivity of the detection of AT/AF. Detection was appropriate in 98% of 132 AF episodes and 88% of 190 AT episodes (98% of 128 AT episodes with an atrial cycle length <300 ms). Intermittent sensing of far-field R waves during sinus tachycardia caused 27 inappropriate AT/AF detections; these detections lasted 2.6+/-2.0 minutes. AT/AF was detected continuously in 27 of 28 patients who had spontaneous episodes of AT/AF (96%). The device memory recorded 90 appropriate AT/AF episodes lasting >1 hour, for a total of 2697 hours of continuous detection of AT/AF. During Holter monitoring, the sensitivity of the detection of AT/AF (116 hours) was 100%; the specificity of the detection of non-AT/AF rhythms (1290 hours) was 99.99%. Of 166 appropriate episodes detected as AT, 45% were terminated by antitachycardia pacing. A new ICD detects AT/AF accurately and continuously. Therapy may be programmed for long-duration AT/AF, with a low risk of underdetection. Discrimination of AT from AF permits successful pacing therapy for a significant fraction of AT.

Enrichment Programs and Professional Development in the Geosciences: Best Practices and Models (OEDG Research Report, Stony Brook University)

ERIC Educational Resources Information Center

Gafney, Leo

2017-01-01

This report is based on several evaluations of NSF-funded geoscience projects at Stony Brook University on Long Island, NY. The report reviews the status of K-12 geoscience education, identifying challenges posed by the Next Generation Science Standards (NGSS), the experiences of university faculty engaged in teacher preparation, state…

Nitrogen and sulfur input-output budgets in the experimental and reference watersheds, Bear Brook Watershed in Maine (BBWM)

Treesearch

J. Kahl; S. Norton; I. Fernandez; L. Rustad; M. Handley

1999-01-01

Dry (NH4)2SO4 (1,800 eq-1 ha-1 yr-1) has been applied to the western of two contiguous 10 ha catchments at the Bear Brook Watershed in Maine (BBWM) since November, 1989. The initial rapid and significant response in both S and N in...

AFS Estuaries Section - A Successful Partnership

EPA Science Inventory

The Estuaries Section of the American Fisheries Society offers travel awards to students in support of their attendance and presentations at the AFS meeting. Since 2007, the Southern Association of Marine Laboratories has partnered with the Estuaries Section to sponsor two stude...

Flood inundation maps and water-surface profiles for tropical storm Irene and selected annual exceedance probability floods for Flint Brook and the Third Branch White River in Roxbury, Vermont

USGS Publications Warehouse

Ahearn, Elizabeth A.; Lombard, Pamela J.

2014-01-01

Flint Brook, a tributary to the Third Branch White River in Roxbury, Vermont, has a history of flooding the Vermont Fish and Wildlife Department’s Roxbury Fish Culture Station (the hatchery) and surrounding infrastructure. Flooding resulting from tropical storm Irene on August 28–29, 2011, caused widespread destruction in the region, including extensive and costly damages to the State-owned hatchery and the transportation infrastructure in the Town of Roxbury, Vermont. Sections of State Route 12A were washed out, and several bridges and culverts on Oxbow Road, Thurston Hill Road, and the New England Central Railroad in Roxbury were heavily damaged. Record high peak-discharge estimates of 2,140 cubic feet per second (ft3/s) and 4,320 ft3/s were calculated for Flint Brook at its confluence with the Third Branch White River and for the Third Branch White River at about 350 feet (ft) downstream from the hatchery, respectively. The annual exceedance probabilities (AEPs) of the peak discharges for Flint Brook and the Third Branch White River were less than 0.2 percent (less than a one in 500 chance of occurring in a given year). Hydrologic and hydraulic analyses of Flint Brook and the Third Branch White River were done to investigate flooding at the hatchery in Roxbury and support efforts by the Federal Emergency Management Agency to assist State and local mitigation and reconstruction efforts. During the August 2011 flood, the majority of flow from Flint Brook (97 percent or 2,070 ft3/s) diverged from its primary watercourse due to a retaining wall failure immediately upstream of Oxbow Road and inundated the hatchery. Although a minor amount of flow from the Third Branch White River could have overtopped State Route 12A and spilled into the hatchery, the Third Branch White River did not cause flood damages or exacerbate flooding at the hatchery during the August 2011 flood. The Third Branch White River which flows adjacent to the hatchery does not flood the hatchery

Zenith-100 Microcomputer Network for Air Command and Staff College.

DTIC Science & Technology

1987-04-01

34 AD-A182 495 ZENI T-ipo ml CROCOMFUT E NET WOR( FOR AIR COMAND AND h SAFF CoLLG (U) AIl COMMAND ANDCSTAFF COLL MAX(WELL AFS "CAL W L GALWAY El AL...processing of documents by eliminating the time required to physically move the documents from one office to the next. Reproduction Savings. Information

Analysis of the Air Force Logistics Enterprise. Evaluation of Global Repair Network Options for Supporting the F-16 and KC-135

DTIC Science & Technology

2009-01-01

Approved for public release; distribution unlimited PROJECT AIR FORCE Ronald G. McGarvey, Manuel Carrillo, Douglas C. Cato, Jr., John G. Drew, Thomas Lang...Planning Framework, Robert S. Tripp, Lionel A. Galway, Paul Killingsworth, Eric Peltz, Timothy Ramey, and John G. Drew (MR-1056-AF). This report describes...Robert S. Tripp, Timothy Ramey, and John G. Drew (MR-1174-AF). This report examines alternatives for meeting F-15 avionics maintenance requirements

Air and Space Power Journal. Volume 16, Number 4, Winter 2002

DTIC Science & Technology

2002-01-01

www.wpafb.af.mil/ museum/research/bombers/ b1 -10.htm. The Oath of Office A Historical Guide to Moral Leadership LT COL KENNETH KESKEL, USAF Editorial...typical of the Royal Air Force (RAF) between the wars, excelling at rugby , boxing, and cricket (in which he was scheduled to compete for England

Swimming behaviour and ascent paths of brook trout in a corrugated culvert

USGS Publications Warehouse

Goerig, Elsa; Bergeron, Normand E.; Castro-Santos, Theodore R.

2017-01-01

Culverts may restrict fish movements under some hydraulic conditions such as shallow flow depths or high velocities. Although swimming capacity imposes limits to passage performance, behaviour also plays an important role in the ability of fish to overcome velocity barriers. Corrugated metal culverts are characterized by unsteady flow and existence of low‐velocity zones, which can improve passage success. Here, we describe swimming behaviour and ascent paths of 148 wild brook trout in a 1.5‐m section of a corrugated metal culvert located in Raquette Stream, Québec, Canada. Five passage trials were conducted in mid‐August, corresponding to specific mean cross‐sectional flow velocities ranging from 0.30 to 0.63 m/s. Fish were individually introduced to the culvert and their movements recorded with a camera located above the water. Lateral and longitudinal positions were recorded at a rate of 3 Hz in order to identify ascent paths. These positions were related to the distribution of flow depths and velocities in the culvert. Brook trout selected flow velocities from 0.2 to 0.5 m/s during their ascents, which corresponded to the available flow velocities in the culvert at the low‐flow conditions. This however resulted in the use of low‐velocity zones at higher flows, mainly located along the walls of the culvert. Some fish also used the corrugations for sheltering, although the behaviour was marginal and did not occur at the highest flow condition. This study improves knowledge on fish behaviour during culvert ascents, which is an important aspect for developing reliable and accurate estimates of fish passage ability.

Rationale and design of the Atrial Fibrillation health Literacy Information Technology Trial: (AF-LITT).

PubMed

Guhl, Emily N; Schlusser, Courtney L; Henault, Lori E; Bickmore, Timothy W; Kimani, Everlyne; Paasche-Orlow, Michael K; Magnani, Jared W

2017-11-01

Atrial Fibrillation (AF) is a common cardiac arrhythmia that is challenging for patients and adversely impacts health-related quality of life (HRQoL). Long-term management of AF requires that patients adhere to complex therapies, understand difficult terminology, navigate subspecialty care, and have continued symptom monitoring with the goal of preventing adverse outcomes. Continued interventions to ameliorate the patient experience of AF are essential. The Atrial Fibrillation health Literacy Information Technology Trial (AF-LITT; NCT03093558) is an investigator-initiated, 2-arm randomized clinical trial (RCT). This RCT is a pilot in order to implement a novel, smartphone-based intervention to address the patient experience of AF. This pilot RCT will compare a combination of the Embodied Conversational Agent (ECA) and the Alive Cor Kardia Mobile heart rhythm monitor to the current standard of care. The study will enroll 180 adults with non-valvular AF who are receiving anticoagulation for stroke prevention and randomize them to receive a 30-day intervention (smartphone-based ECA/Kardia) or standard of care, which will include a symptom and adherence journal. The primary end-points are improvement in HRQoL and self-reported adherence to anticoagulation. The secondary end-points are the acceptability of the intervention to participants, its use by participants, and acceptability to referring physicians. The AF-LITT pilot aims to evaluate the efficacy of the ECA/Kardia to improve HRQoL and anticoagulant adherence, and to guide its implementation in a larger, multicenter clinical trial. The intervention has potential to improve HRQoL, adherence, and health care utilization in individuals with chronic AF. Copyright © 2017 Elsevier Inc. All rights reserved.

Rationale and design of the Atrial Fibrillation health Literacy Information Technology Trial: (AF-LITT)

PubMed Central

Guhl, Emily N.; Schlusser, Courtney L.; Henault, Lori E.; Bickmore, Timothy W.; Kimani, Everlyne; Paasche-Orlow, Michael K.; Magnani, Jared W.

2017-01-01

Background Atrial Fibrillation (AF) is a common cardiac arrhythmia that is challenging for patients and adversely impacts health-related quality of life (HRQoL). Long-term management of AF requires that patients adhere to complex therapies, understand difficult terminology, navigate subspecialty care, and have continued symptom monitoring with the goal of preventing adverse outcomes. Continued interventions to ameliorate the patient experience of AF are essential. Design The Atrial Fibrillation health Literacy Information Technology Trial (AF-LITT; NCT03093558) is an investigator-initiated, 2-arm randomized clinical trial (RCT). This RCT is a pilot in order to implement a novel, smartphone-based intervention to address the patient experience of AF. This pilot RCT will compare a combination of the embodied conversational agent (ECA) and the Alive Cor Kardia Mobile heart rhythm monitor to the current standard of care. The study will enroll 180 adults with non-valvular AF who are receiving anticoagulation for stroke prevention and randomize them to receive a 30-day intervention (smartphone-based ECA/Kardia) or standard of care, which will include a symptom and adherence journal. The primary end-points are improvement in HRQoL and self-reported adherence to anticoagulation. The secondary end-points are the acceptability of the intervention to participants, its use by participants, and acceptability to referring physicians. Conclusions The AF-LITT pilot aims to evaluate the efficacy of the ECA/Kardia to improve HRQoL and anticoagulant adherence, and to guide its implementation in a larger, multicenter clinical trial. The intervention has potential to improve HRQoL, adherence, and health care utilization in individuals with chronic AF. PMID:28923492

Final Environmental Assessment Construction of New Recreational Lodging at Bellows Air Force Station O’ahu, Hawai’i

DTIC Science & Technology

2009-10-01

FINDING OF NO SIGNIFICANT IMPACT ENVIRONMENTAL ASSESSMENT CONSTRUCTION OF NEW RECREATIONAL LODGING AT BELLOWS AIR FORCE STATION , O’AHU, HAWAri... Environmental Assessment for the Proposed Construction of New Recreational Lodging at Bellows Air Force Station , O’ahu, Hawaii 1. The 15th Airlift Wing (15...A W) is prepanng an Environmental Assessment to address the proposed Construction of New Recreational Lodging at Bellows Air Force Station (AFS

Eleven-year response of foliar chemistry to chronic nitrogen and sulfur additions at the Bear Brook Watershed in Maine

Treesearch

Jose Alexander Elvir; Lindsey Rustad; G. Bruce Wiersma; Ivan Fernandez; Alan S. White; Gregory J. White

2005-01-01

The foliar chemistry of sugar maple (Acer saccharum Marsh.), American beech (Fagus grandifolia Ehrh.), and red spruce (Picea rubens Sarg.) was studied from 1993 to 2003 at the Bear Brook Watershed in Maine (BBWM). The BBWM is a paired-watershed forest ecosystem study, with one watershed treated bimonthly since...

Incidence and economic burden of suspected adverse events and adverse event monitoring during AF therapy.

PubMed

Kim, M H; Lin, J; Hussein, M; Battleman, D

2009-12-01

Rhythm- and rate-control therapies are an essential part of atrial fibrillation (AF) management; however, the use of existing agents is often limited by the occurrence of adverse events. The aim of this study was to evaluate suspected adverse events and adverse event monitoring, and associated medical costs, in patients receiving AF rhythm-control and/or rate-control therapy. This retrospective cohort study used claims data from the Integrated Healthcare Information Systems National Managed Care Benchmark Database from 2002-2006. Patients hospitalized for AF (primary diagnosis), and who had at least 365 days' enrollment before and after the initial (index) AF hospitalization, were included in the analysis. Suspected AF therapy-related adverse events and function tests for adverse event monitoring were identified according to pre-specified diagnosis codes/procedures, and examined over the 12 months following discharge from the index hospitalization. Events/function tests had to have occurred within 90 days of a claim for AF therapy to be considered a suspected adverse event/adverse event monitoring. Of 4174 AF patients meeting the study criteria, 3323 received AF drugs; 428 received rhythm-control only (12.9%), 2130 rate-control only (64.1%), and 765 combined rhythm/rate-control therapy (23.0%). Overall, 50.1% of treated patients had a suspected adverse event and/or function test for adverse event monitoring (45.5% with rate-control, 53.5% with rhythm-control, and 61.2% with combined rhythm/rate-control). Suspected cardiovascular adverse events were the most common events (occurring in 36.1% of patients), followed by pulmonary (6.1%), and endocrine events (5.9%). Overall, suspected adverse events/function tests were associated with mean annual per-patient costs of $3089 ($1750 with rhythm-control, $2041 with rate control, and $6755 with combined rhythm/rate-control). As a retrospective analysis, the study is subject to potential selection bias, while its reliance on

PACAF A-10s, HH-60s fly first air contingent missions in Philippines > U.S.

Science.gov Websites

the CMSAF The Book Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games Games Portraits in Courage Portraits In Courage Vol. I Portraits In Courage Vol. II Portraits In Courage

Functional characterization of the copper transcription factor AfMac1 from Aspergillus fumigatus.

PubMed

Park, Yong-Sung; Kim, Tae-Hyoung; Yun, Cheol-Won

2017-07-03

Although copper functions as a cofactor in many physiological processes, copper overload leads to harmful effects in living cells. Thus, copper homeostasis is tightly regulated. However, detailed copper metabolic pathways have not yet been identified in filamentous fungi. In this report, we investigated the copper transcription factor AfMac1 ( A spergillus f umigatus Mac1 homolog) and identified its regulatory mechanism in A. fumigatus AfMac1 has domains homologous to the DNA-binding and copper-binding domains of Mac1 from Saccharomyces cerevisiae , and AfMac1 efficiently complemented Mac1 in S. cerevisiae Expression of Afmac1 resulted in CTR1 up-regulation, and mutation of the DNA-binding domain of Afmac1 failed to activate CTR1 expression in S. cerevisiae The Afmac1 deletion strain of A. fumigatus failed to grow in copper-limited media, and its growth was restored by introducing ctrC We found that AfMac1 specifically bound to the promoter region of ctrC based on EMSA. The AfMac1-binding motif 5'-TGTGCTCA-3' was identified from the promoter region of ctrC , and the addition of mutant ctrC lacking the AfMac1-binding motif failed to up-regulate ctrC in A. fumigatus Furthermore, deletion of Afmac1 significantly reduced strain virulence and activated conidial killing activity by neutrophils and macrophages. Taken together, these results suggest that AfMac1 is a copper transcription factor that regulates cellular copper homeostasis in A. fumigatus . © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society.

K-Ar geochronology of the Survey Pass, Ambler River and Eastern Baird Mountains quadrangles, southwestern Brooks Range, Alaska

USGS Publications Warehouse

Turner, Donald L.; Forbes, R.B.; Mayfield, C.F.

1978-01-01

We report 76 previously unpublished K-Ar mineral ages from 47 metamorphic and igneous rocks in the southwestern Brooks Range. The pattern of radiometric ages is complex, reflecting the complex geologic history of this area. Local and regional radiometric evidence suggests that the southern Brooks Range schist belt has, at least in part, undergone a late Precambrian metamorphism and that the parent sedimentary and igneous rocks for the metamorphic rocks dated as late Precambrian are at least this old (Precambrian Z). This schist terrane experienced a major thermal event in mid-Cretaceous time, causing widespread resetting of nearly all K-Ar mica ages. A series of apparent ages intermediate between late Precambrian and mid-Cretaceous are interpreted as indicating varying amounts of partial argon loss from older rocks during the Cretaceous event. The schist belt is characterized by dominant metasediments and subordinate metabasites and metafelsites. Blueschists occur within the schist belt from the Chandalar quadrangle westward to the Baird Mountains quadrangle, but geologic evidence does not support the existence of a fossil subduction zone.

Selection and preference of benthic habitat by small and large ammocoetes of the least brook lamprey (Lampetra aepyptera)

USGS Publications Warehouse

Smith, D.M.; Welsh, S.A.; Turk, P.J.

2011-01-01

In this laboratory study, we quantified substrate selection by small (<50 mm) and large (100-150 mm) ammocoetes of the least brook lamprey (Lampetra aepyptera). In aquaria, ammocoetes were given a choice to burrow into six equally-available substrate types: small gravel (2.360-4.750 mm), coarse sand (0.500-1.400 mm), fine sand (0.125-0.500 mm), organic substrate (approximately 70% decomposing leaves/stems and organic sediment particles, and 30% silt and fine sand), an even mixture of silt, clay, and fine sand, and silt/clay (<0.063 mm). Fine sand was selected with a significantly higher probability than any other substrate. Fine sand habitat is limited in many streams, in part owing to geology, but also as a result of channelization and excessive silt/clay sedimentation, which is a conservation concern. Our results indicate that ammocoetes of least brook lampreys are habitat specialists that prefer fine sand habitat. Hence, availability of fine sand habitat may limit distributions and population sizes. ?? 2011 Springer Science+Business Media B.V.

Simultaneous adsorption of Cu2+ and Acid fuchsin (AF) from aqueous solutions by CMC/bentonite composite.

PubMed

Gong, Ning; Liu, Yanping; Huang, Ruihua

2018-04-21

Carboxymethyl-chitosan (CMC)/bentonite composite was prepared by the method of membrane-forming, and characterized by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) techniques. The simultaneous adsorption of Cu 2+ and Acid fuchsin (AF) applying CMC/bentonite composite as an adsorbent in single or binary systems was investigated. The adsorption study was conducted systematically by varying the ratio of CMC to bentonite, adsorbent dosage, initial pH value, initial Cu 2+ (or AF) concentration, contact time and the interaction of two components in binary solutions. The results showed that the presence of Cu 2+ hindered the adsorption of AF, while the presence of AF almost had no influence on the adsorption of Cu 2+ in binary systems. The adsorption data of Cu 2+ and AF were both suitable for Langmuir isotherm model, and the maximum adsorption capacities of CMC/bentonite composite, according to the Langmuir isotherm model were 81.4 mg/g for Cu 2+ and 253.2 mg/g for AF at 298 K. The pseudo-second-order model could better describe the adsorption process of Cu 2+ and AF. Thermodynamic constant values illustrated that the adsorption of Cu 2+ was endothermic, while the adsorption process of AF was exothermic. Copyright © 2018. Published by Elsevier B.V.

Do native brown trout and non-native brook trout interact reproductively?

NASA Astrophysics Data System (ADS)

Cucherousset, J.; Aymes, J. C.; Poulet, N.; Santoul, F.; Céréghino, R.

2008-07-01

Reproductive interactions between native and non-native species of fish have received little attention compared to other types of interactions such as predation or competition for food and habitat. We studied the reproductive interactions between non-native brook trout ( Salvelinus fontinalis) and native brown trout ( Salmo trutta) in a Pyrenees Mountain stream (SW France). We found evidence of significant interspecific interactions owing to consistent spatial and temporal overlap in redd localizations and spawning periods. We observed mixed spawning groups composed of the two species, interspecific subordinate males, and presence of natural hybrids (tiger trout). These reproductive interactions could be detrimental to the reproduction success of both species. Our study shows that non-native species might have detrimental effects on native species via subtle hybridization behavior.

Breaking the speed limit--comparative sprinting performance of brook trout (Salvelinus fontinalis) and brown trout (Salmo trutta)

USGS Publications Warehouse

Castro-Santos, Theodore; Sanz-Ronda, Francisco Javier; Ruiz-Legazpi, Jorge

2013-01-01

Sprinting behavior of free-ranging fish has long been thought to exceed that of captive fish. Here we present data from wild-caught brook trout (Salvelinus fontinalis) and brown trout (Salmo trutta), volitionally entering and sprinting against high-velocity flows in an open-channel flume. Performance of the two species was nearly identical, with the species attaining absolute speeds > 25 body lengths·s−1. These speeds far exceed previously published observations for any salmonid species and contribute to the mounting evidence that commonly accepted estimates of swimming performance are low. Brook trout demonstrated two distinct modes in the relationship between swim speed and fatigue time, similar to the shift from prolonged to sprint mode described by other authors, but in this case occurring at speeds > 19 body lengths·s−1. This is the first demonstration of multiple modes of sprint swimming at such high swim speeds. Neither species optimized for distance maximization, however, indicating that physiological limits alone are poor predictors of swimming performance. By combining distributions of volitional swim speeds with endurance, we were able to account for >80% of the variation in distance traversed by both species.

The United States Air Force Academy: A Bibliography: 1968 - 1972

DTIC Science & Technology

1972-09-01

Hist - Aerospace Historian Aero Med - Aerospace Medicine Air Reservist Airman America Armed Forces Compt - Armed Forces Comptroller Armed Forces J...center for aviary medicine . Airman 15:48, May 1971. 235 Jeans, Kit. Children learn at Academy school--CHAP pro- gram. AF Times 30:26, 29 Apr...Indoctrination 10355 Merit lists 10356 Organization 10330 Wing strength 10354 Marihuana incidents 10912 Marriage of cadet 10326

Draft Genome Sequence of a Picorna-Like Virus Associated with Gill Tissue in Clinically Normal Brook Trout, Salvelinus fontinalis.

PubMed

Iwanowicz, Luke R; Iwanowicz, Deborah D; Adams, Cynthia R; Galbraith, Heather; Aunins, Aaron; Cornman, Robert S

2017-10-12

Here, we report a draft genome sequence of a picorna-like virus associated with brook trout, Salvelinus fontinalis , gill tissue. The draft genome comprises 8,681 nucleotides, excluding the poly(A) tract, and contains two open reading frames. It is most similar to picorna-like viruses that infect invertebrates.

Draft genome sequence of a picorna-like virus associated with gill tissue in clinically normal brook trout, Salvelinus fontinalis

USGS Publications Warehouse

Iwanowicz, Luke R.; Iwanowicz, Deborah; Adams, Cynthia; Galbraith, Heather S.; Aunins, Aaron W.; Cornman, Robert S.

2017-01-01

Here, we report a draft genome sequence of a picorna-like virus associated with brook trout, Salvelinus fontinalis, gill tissue. The draft genome comprises 8,681 nucleotides, excluding the poly(A) tract, and contains two open reading frames. It is most similar to picorna-like viruses that infect invertebrates.

Media Literacy, News Literacy, or News Appreciation? A Case Study of the News Literacy Program at Stony Brook University

ERIC Educational Resources Information Center

Fleming, Jennifer

2014-01-01

This case study provides practical and theoretical insights into the Stony Brook news literacy program, which is one of the most ambitious and well-funded curricular experiments in modern journalism education and media literacy. Analysis of document, interview, and observation data indicates that news literacy educators sought to teach students…

AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease

PubMed Central

Haskin, Joseph; Szargel, Raymonde; Shani, Vered; Mekies, Lucy N.; Rott, Ruth; Lim, Grace G. Y.; Lim, Kah-Leong; Bandopadhyay, Rina; Wolosker, Herman; Engelender, Simone

2013-01-01

Parkin E3 ubiquitin-ligase activity and its role in mitochondria homeostasis are thought to play a role in Parkinson's disease (PD). We now report that AF-6 is a novel parkin interacting protein that modulates parkin ubiquitin-ligase activity and mitochondrial roles. Parkin interacts with the AF-6 PDZ region through its C-terminus. This leads to ubiquitination of cytosolic AF-6 and its degradation by the proteasome. On the other hand, endogenous AF-6 robustly increases parkin translocation and ubiquitin-ligase activity at the mitochondria. Mitochondrial AF-6 is not a parkin substrate, but rather co-localizes with parkin and enhances mitochondria degradation through PINK1/parkin-mediated mitophagy. On the other hand, several parkin and PINK1 juvenile disease-mutants are insensitive to AF-6 effects. AF-6 is present in Lewy bodies and its soluble levels are strikingly decreased in the caudate/putamen and substantia nigra of sporadic PD patients, suggesting that decreased AF-6 levels may contribute to the accumulation of dysfunctional mitochondria in the disease. The identification of AF-6 as a positive modulator of parkin translocation to the mitochondria sheds light on the mechanisms involved in PD and underscores AF-6 as a novel target for future therapeutics. PMID:23393160

Evaluation of the atoxigenic Aspergillus flavus strain AF36 in pistachio orchards

USDA-ARS?s Scientific Manuscript database

The atoxigenic strain Aspergillus flavus AF36, which has been extensively used as a biocontrol agent in commercial corn and cotton fields to reduce aflatoxin contamination, was applied in research pistachio orchards from 2002 to 2005 and in commercial pistachio orchards from 2008 to 2011. AF36 was a...

Diversifying and correlational selection on behavior toward conspecific and heterospecific competitors in brook stickleback (Culaea inconstans)

PubMed Central

Peiman, Kathryn S; Robinson, Beren W

2012-01-01

Behaviors toward heterospecifics and conspecifics may be correlated because of shared mechanisms of expression in both social contexts (nonadaptive covariation) or because correlational selection favors adaptive covariation. We evaluated these hypotheses by comparing behavior toward conspecifics and heterospecifics in brook stickleback (Culaea inconstans) from three populations sympatric with and three allopatric from a competitor, the ninespine stickleback (Pungitius pungitius). Behavioral traits were classified into three multivariate components: overt aggression, sociability, and activity. The correlation of behavior between social contexts for both overt aggression and activity varied among populations in a way unrelated to sympatry with ninespine stickleback, while mean aggression was reduced in sympatry. Correlations in allopatric populations suggest that overt aggression and activity may genetically covary between social contexts for nonadaptive reasons. Sociability was rarely correlated in allopatry but was consistently correlated in sympatry despite reduced mean sociability, suggesting that correlational selection may favor a sociability syndrome in brook stickleback when they coexist with ninespine stickleback. Thus, interspecific competition may impose diversifying selection on behavior among populations, although the causes of correlated behavior toward conspecifics and heterospecifics and whether it can evolve in one social context independent of the other may depend on the type of behavior. PMID:23139874

The Shock and Vibration Bulletin. Part 2. Structural Analysis, Design Techniques

DTIC Science & Technology

1973-06-01

FLOATING SHOCK PLATFORM SUBJECTED TO UNDERWATER EXPLOSIONS R. P. Brooks, and B. C, McNalght Naval Air Engineering Center Philadelphia, Pa, A lumped...Lohwasser, Air Force Flight Dynamics Laboratory, Wright -Patterson APB, Ohio AN ALGORITHM FOR SEMI-INVERSE ANALYSIS OF NONLINEAR DYNAMIC SYSTEMS ... 65 R...MATHEMATICAL MODEL OF A TYPICAL.FOATING SHOCK PLATFORM SSUBJECTED TO-UNDERWATE- EXPLOSIONS .......... ...................... 143 R. P. Brooks and B. C

Stroke of Known Cause and Underlying Atrial Fibrillation (STROKE-AF) randomized trial: Design and rationale.

PubMed

Bernstein, Richard A; Kamel, Hooman; Granger, Christopher B; Kowal, Robert C; Ziegler, Paul D; Schwamm, Lee H

2017-08-01

Approximately 20% of ischemic strokes are associated with clinically apparent atrial fibrillation (AF). Regardless of stroke etiology, detection of AF in patients with ischemic strokes often changes antithrombotic treatment from anti-platelet to oral anticoagulation therapy. The role and the optimum duration of cardiac monitoring to detect AF in patients with strokes presumed due to large vessel atherosclerosis or small vessel disease is unknown. This manuscript describes the design and rationale of the STROKE-AF trial. STROKE-AF is a randomized, controlled, open-label, post-market clinical trial. Detection of AF will be evaluated using continuous arrhythmia monitoring with an insertable cardiac monitor (ICM) compared with standard of care follow-up in patients with stroke (within the prior 10 days) that is presumed due to large vessel cervical or intracranial atherosclerosis, or to small vessel disease. Approximately 500 patients will be enrolled at approximately 40 centers in the United States. Patients will be randomized 1:1 to arrhythmia monitoring with an ICM (continuous monitoring arm) or standard of care follow-up (control arm). Subjects will be followed for ≥12 months and up to 3 years. The primary objective is to compare the incidence rate of detected AF through 12 months of follow-up between the two arms. This trial will provide information on the value of ICMs to detect subclinical AF in patients with stroke presumed due to large vessel atherosclerosis or small vessel disease, which will have implications for guiding treatment with oral anticoagulation for secondary stroke prevention. Copyright © 2017 Elsevier Inc. All rights reserved.

Speciation of antimony in airborne particulate matter using ultrasound probe fast extraction and analysis by HPLC-HG-AFS.

PubMed

Bellido-Martín, A; Gómez-Ariza, J L; Smichowsky, P; Sánchez-Rodas, D

2009-09-07

A fast extraction procedure has been developed for Sb(III) and Sb(V) oxoanions speciation in airborne particulate matter samples. Different extraction media (diammonium tartrate, hidroxilammonium clorhidrate, citric acid+ascorbic acid, phosphoric acid and citrate solutions) were tried, with assistance of an ultrasonic probe. The operation power and time of extraction were also optimized. The higher extraction recoveries were obtained with a 100 mmol L(-1) hidroxilammonium clorhidrate aqueous solution assisted by the ultrasound probe operated at 50 W during 3 min. The extracts were analyzed by HPLC-HG-AFS. The chromatographic separation of Sb(III) and Sb(V) was also optimized using diammonium tartrate and phthalic acid as mobile phases. The separation of both Sb species was performed in less than 3 min under isocratic conditions, using a 200 mmol L(-1) diammonium tartrate solution. The proposed extraction procedure and the HPLC-HG-AFS instrumental coupling have been successfully applied to airborne particulate matter samples, with high Sb content, collected in heavy traffic streets from Buenos Aires (Argentina). The results showed the presence of both Sb species at similar concentrations in the ng m(-3) level. The extraction yield was higher than 90% for all the analyzed samples.

Damage to cochlear efferents following AF64A intoxication.

PubMed

Smith, D W; Mount, R J

1993-07-01

Damage to cochlear efferents in chinchillas was assessed using transmission electron microscopy following unilateral treatment with the cholinotoxin ethylcholine mustard aziridinium ion (AF64A). AF64A was diluted in artificial perilymph to concentrations ranging from 0.5 to 100 microM. Survival times ranged from 1 to 12 weeks. At concentrations above 10 microM, widespread damage was noted to efferent fibers within the inner spiral bundle (ISB), tunnel spiral bundle (TSB), tunnel radial fibers (TRF) and efferent terminals at the base of OHCs. This damage included degeneration of fibers and terminals, delamination of mitochondria, vacuolization, and loss of cell membrane. However, at high concentrations, non-specific damage was also noted as thinnings or discontinuities of the membrane of OHCs and afferent fibers. At concentrations between 3 and 10 microM, selective damage was observed to efferent fibers within the ISB, TSB, TRF, and to terminals at the base of the OHCs, with all other structures appearing normal. At concentrations of 0.5 and 1 microM, damage was limited to efferent fibers within the TSB and ISB below the inner hair cells. In general, insult was greatest to middle- and basal-turn efferents, and longer survival times did not produce greater damage to, or loss of, efferents. These data suggest that at low concentrations, AF64A produces a partial yet selective degeneration of cochlear efferents within both the medial and lateral tracts, and that at the lowest concentrations used in these studies, AF64A produces a preferential insult on lateral olivocochlear efferents.

The splicing factor U2AF65 stabilizes TRF1 protein by inhibiting its ubiquitin-dependent proteolysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Jeonghee; Chung, In Kwon, E-mail: topoviro@yonsei.ac.kr

Highlights: •Identification of U2AF65 as a novel TRF1-interacting protein. •U2AF65 stabilizes TRF1 protein by inhibiting its ubiquitin-dependent proteolysis. •U2AF65 interferes with the interaction between TRF1 and Fbx4. •U2AF65 represents a new route for modulating TRF1 function at telomeres. -- Abstract: The human telomeric protein TRF1 is a component of the six-subunit protein complex shelterin, which provides telomere protection by organizing the telomere into a high-order structure. TRF1 functions as a negative regulator of telomere length by controlling the access of telomerase to telomeres. Thus, the cellular abundance of TRF1 at telomeres should be maintained and tightly regulated to ensure propermore » telomere function. Here, we identify U2 small nuclear ribonucleoprotein (snRNP) auxiliary factor 65 (U2AF65), an essential pre-mRNA splicing factor, as a novel TRF1-interacting protein. U2AF65 interacts with TRF1 in vitro and in vivo and is capable of stabilizing TRF1 protein by inhibiting its ubiquitin-dependent proteolysis. We also found that U2AF65 interferes with the interaction between TRF1 and Fbx4, an E3 ubiquitin ligase for TRF1. Depletion of endogenous U2AF65 expression by short interfering RNA (siRNA) reduced the stability of endogenous TRF1 whereas overexpression of U2AF65 significantly extended the half-life of TRF1. These findings demonstrate that U2AF65 plays a critical role in regulating the level of TRF1 through physical interaction and ubiquitin-mediated proteolysis. Hence, U2AF65 represents a new route for modulating TRF1 function at telomeres.« less

Draft Genome Sequence of a Picorna-Like Virus Associated with Gill Tissue in Clinically Normal Brook Trout, Salvelinus fontinalis

PubMed Central

2017-01-01

ABSTRACT Here, we report a draft genome sequence of a picorna-like virus associated with brook trout, Salvelinus fontinalis, gill tissue. The draft genome comprises 8,681 nucleotides, excluding the poly(A) tract, and contains two open reading frames. It is most similar to picorna-like viruses that infect invertebrates. PMID:29025930

Examining Scientific and Technical Writing Strategies in the 11th Century Chinese Science Book "Brush Talks from Dream Brook"

ERIC Educational Resources Information Center

Zhang, Yuejiao

2013-01-01

This article examines the influential Chinese science book "Brush Talks from Dream Brook," written by Shen Kuo in the 11th century. I suggest that "Brush Talks" reveals a tension between institutionalized science and science in the public, and a gap between the making of scientific knowledge and the communication of such…

Neglecting Democracy in Education Policy: A-F School Report Card Accountability Systems

ERIC Educational Resources Information Center

Murray, Kevin; Howe, Kenneth R.

2017-01-01

Sixteen states have adopted school report card accountability systems that assign A-F letter grades to schools. Other states are now engaged in deliberation about whether they, too, should adopt such systems. This paper examines A-F accountability systems with respect to three kinds of validity. First, it examines whether or not these…

TOXICITY OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TO EARLY LIFE STAGE BROOK TROUT (SALVELINUS FONTINALIS) FOLLOWING PARENTAL DIETARY EXPOSURE

EPA Science Inventory

The toxicity of TCDD to early life stages of F1 generation brook trout (Salvelinus fontinalis) was determined when dosed by maternal transfer. Effects were compared across six treatments including a control. The experimental groups based on TCDD concentrations in freshly spawned ...

[Establishment of the retrovirus-mediated murine model with MLL-AF9 leukemia].

PubMed

Xu, Si-Miao; Yang, Yang; Zhou, Mi; Zhao, Xue-Jiao; Qin, Yu; Zhang, Pei-Ling; Yuan, Rui-Feng; Zhou, Jian-Feng; Fang, Yong

2013-10-01

This study was purposed to establish a retrovirus-mediated murine model with MLL-AF9 leukemia, so as to provide a basis for further investigation of the pathogenesis and therapeutic strategy of MLL associated leukemia. Murine (CD45.2) primary hematopoietic precursor positively selected for expression of the progenitor marker c-Kit by means of MACS were transduced with a retrovirus carrying MLL-AF9 fusion gene. After cultured in vitro, the transduced cells were injected intravenously through the tail vein into the lethally irradiated mice (CD45.1). PCR, flow cytometry and morphological observation were employed to evaluate the murine leukemia model system. The results showed that MLL-AF9 fusion gene was expressed in the infected cells, and the cells had a dramatically enhanced potential to generate myeloid colonies with primitive and immature morphology. Flow cytometric analysis revealed that the immortalized cells highly expressed myeloid lineage surface markers Gr-1 and Mac-1. Moreover, the expression levels of Hoxa9 and Meis1 mRNA were significantly higher in the MLL-AF9 cells than that in control. The mice transplanted with MLL-AF9 cells displayed typical signs of leukemia within 6-12 weeks. Extensive infiltration leukemic cells was observed in the Wright-Giemsa stained peripheral blood smear and bone marrow, and also in the histology of liver and spleen. Flow cytometric analysis of the bone marrow and spleen cells demonstrated that the CD45.2 populations expressed highly myeloid markers Gr-1 and Mac-1. The leukemic mice died within 12 weeks. It is concluded that the retrovirus-mediated murine model with MLL-AF9 leukemia is successfully established, which can be applied in the subsequent researches.

Pathway and rate-limiting step of glyphosate degradation by Aspergillus oryzae A-F02.

PubMed

Fu, Gui-Ming; Chen, Yan; Li, Ru-Yi; Yuan, Xiao-Qiang; Liu, Cheng-Mei; Li, Bin; Wan, Yin

2017-09-14

Aspergillus oryzae A-F02, a glyphosate-degrading fungus, was isolated from an aeration tank in a pesticide factory. The pathway and rate-limiting step of glyphosate (GP) degradation were investigated through metabolite analysis. GP, aminomethylphosphonic acid (AMPA), and methylamine were detected in the fermentation liquid of A. oryzae A-F02, whereas sarcosine and glycine were not. The pathway of GP degradation in A. oryzae A-F02 was revealed: GP was first degraded into AMPA, which was then degraded into methylamine. Finally, methylamine was further degraded into other products. Investigating the effects of the exogenous addition of substrates and metabolites showed that the degradation of GP to AMPA is the rate-limiting step of GP degradation by A. oryzae A-F02. In addition, the accumulation of AMPA and methylamine did not cause feedback inhibition in GP degradation. Results showed that degrading GP to AMPA was a crucial step in the degradation of GP, which determines the degradation rate of GP by A. oryzae A-F02.

Low strain, long life creep fatigue of AF2-1DA and INCO 718

NASA Technical Reports Server (NTRS)

Thakker, A. B.; Cowles, B. A.

1983-01-01

Two aircraft turbine disk alloys, GATORIZED AF2-DA and INCO 718 were evaluated for their low strain long life creep-fatigue behavior. Static (tensile and creep rupture) and cyclic properties of both alloys were characterized. The cntrolled strain LCF tests were conducted at 760 C (1400 F) and 649 C (1200 F) for AF2-1DA and INCO 718, respectively. Hold times were varied for tensile, compressive and tensile/compressive strain dwell (relaxation) tests. Stress (creep) hold behavior of AF2-1DA was also evaluated. Generally, INCO 718 exhibited more pronounced reduction in cyclic life due to hold than AF2-1DA. The percent reduction in life for both alloys for strain dwell tests was greater at low strain ranges (longer life regime). Changing hold time from 0 to 0.5, 2.0 and 15.0 min. resulted in corresponding reductions in life. The continuous cycle and cyclic/dwell initiation failure mechanism was predominantly transgranular for AF2-1DA and intergranular for INCO 718.

Cardiovascular risk profile and management of atrial fibrillation in India: Real world data from RealiseAF survey.

PubMed

Narasimhan, C; Verma, Jagmohan Singh; Ravi Kishore, A G; Singh, Balbir; Dani, Sameer; Chawala, Kamaldeep; Haque, Azizul; Khan, Aftab; Nair, Mohan; Vora, Amit; Rajasekhar, V; Thomas, Joy M; Gupta, Anoop; Naik, Ajay; Prakash, V S; Naditch, Lisa; Gabriel Steg, P

Atrial fibrillation (AF) is the most common sustained arrhythmia with high risk for many cardiovascular (CV) complications. Adherence to recommended management guidelines is important to avoid complications. In India, there is little knowledge on how AF is managed in real world. This is a cross-sectional study of patients in India enrolled in RealiseAF survey between February 2010 and March 2010 with a diagnosis of AF within the last 12 months. From 15 centers, 301 patients {mean age 59.9 years (14.4); 52.5% males} were recruited. AF was controlled in 50% of patients with 77 (26.7%) in sinus rhythm and 67 (23.3%) with heart rate <80beats/min. Hypertension (50.8%), valvular heart disease (40.7%), heart failure (25.9%), and diabetes (20.4%) were the most common underlying CV diseases. Increased risk for stroke (CHADS 2 score≥2) was present in 36.6%. Most of the patients (85%) were symptomatic. AF was paroxysmal, persistent, and permanent in 28.7%, 22.7%, and 34.3% respectively. In 14%, AF was diagnosed as first episode. Forty-six percent of patients had rate control, 35.2% rhythm control, 0.3% both strategies, and 18.4% received no therapy for AF before the visit. At the end of the visit, adoption to rate control strategy increased to 52.3% and patients with no therapy decreased to 7%. AF in India is not adequately controlled. Concomitant CV risk factors and risk of stroke are high. The study underscores the need for improved adoption of guideline-directed management for optimal control of AF and reducing the risk of stroke. Copyright © 2016. Published by Elsevier B.V.

Rivaroxaban vs. warfarin in Japanese patients with atrial fibrillation – the J-ROCKET AF study –.

PubMed

Hori, Masatsugu; Matsumoto, Masayasu; Tanahashi, Norio; Momomura, Shin-ichi; Uchiyama, Shinichiro; Goto, Shinya; Izumi, Tohru; Koretsune, Yukihiro; Kajikawa, Mariko; Kato, Masaharu; Ueda, Hitoshi; Iwamoto, Kazuya; Tajiri, Masahiro

2012-01-01

The global ROCKET AF study evaluated once-daily rivaroxaban vs. warfarin for stroke and systemic embolism prevention in patients with atrial fibrillation (AF). A separate trial, J-ROCKET AF, compared the safety of a Japan-specific rivaroxaban dose with warfarin administered according to Japanese guidelines in Japanese patients with AF. J-ROCKET AF was a prospective, randomized, double-blind, phase III trial. Patients (n=1,280) with non-valvular AF at increased risk for stroke were randomized to receive 15 mg once-daily rivaroxaban or warfarin dose-adjusted according to Japanese guidelines. The primary objective was to determine non-inferiority of rivaroxaban against warfarin for the principal safety outcome of major and non-major clinically relevant bleeding, in the on-treatment safety population. The primary efficacy endpoint was the composite of stroke and systemic embolism. Non-inferiority of rivaroxaban to warfarin was confirmed; the rate of the principal safety outcome was 18.04% per year in rivaroxaban-treated patients and 16.42% per year in warfarin-treated patients (hazard ratio [HR] 1.11; 95% confidence interval 0.87-1.42; P<0.001 [non-inferiority]). Intracranial hemorrhage rates were 0.8% with rivaroxaban and 1.6% with warfarin. There was a strong trend for a reduction in the rate of stroke/systemic embolism with rivaroxaban vs. warfarin (HR, 0.49; P=0.050). J-ROCKET AF demonstrated the safety of a Japan-specific rivaroxaban dose and supports bridging the global ROCKET AF results into Japanese clinical practice.

Microsatellite variation and genetic structure of brook trout (Salvelinus fontinalis) populations in Labrador and neighboring Atlantic Canada: evidence for ongoing gene flow and dual routes of post-Wisconsinan colonization

PubMed Central

Pilgrim, Brettney L; Perry, Robert C; Keefe, Donald G; Perry, Elizabeth A; Dawn Marshall, H

2012-01-01

In conservation genetics and management, it is important to understand the contribution of historical and contemporary processes to geographic patterns of genetic structure in order to characterize and preserve diversity. As part of a 10-year monitoring program by the Government of Newfoundland and Labrador, Canada, we measured the population genetic structure of the world's most northern native populations of brook trout (Salvelinus fontinalis) in Labrador to gather baseline data to facilitate monitoring of future impacts of the recently opened Trans-Labrador Highway. Six-locus microsatellite profiles were obtained from 1130 fish representing 32 populations from six local regions. Genetic diversity in brook trout populations in Labrador (average HE= 0.620) is within the spectrum of variability found in other brook trout across their northeastern range, with limited ongoing gene flow occurring between populations (average pairwise FST= 0.139). Evidence for some contribution of historical processes shaping genetic structure was inferred from an isolation-by-distance analysis, while dual routes of post-Wisconsinan recolonization were indicated by STRUCTURE analysis: K= 2 was the most likely number of genetic groups, revealing a separation between northern and west-central Labrador from all remaining populations. Our results represent the first data from the nuclear genome of brook trout in Labrador and emphasize the usefulness of microsatellite data for revealing the extent to which genetic structure is shaped by both historical and contemporary processes. PMID:22837834

TOXICITY OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TO EARLY LIFE STAGE BROOK TROUT (SALVELINUS FONTINALIS) FOLLOWING PARTENTAL DIETARY EXPOSURE

EPA Science Inventory

The toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to the early life stages of F1 generation brook trout (Salvelinus fontinalis) was determined, when dosed by maternal transfer.Effects were compared across six treatments, including a control.The experimental groups, based...

ACIDIFICATION TRENDS AND THE EVOLUTION OF NEUTRALIZATION MECHANISMS THROUGH TIME AT THE BEAR BROOK WATERSHED IN MAINE (BBWM), U.S.A.

EPA Science Inventory

The paired catchment study at the forested Bear Brook Watershed in Maine (BBWM) U.S.A. documents interactions among short- to long-term processes of acidification. In 1987-1989, runoff from the two catchments was nearly identical in quality and quantity. Ammonium sulfate has been...

Reconnaissance exploration geochemistry in the central Brooks Range, northern Alaska: Implications for exploration of sediment-hosted zinc-lead-silver deposits

USGS Publications Warehouse

Kelley, K.D.; Kelley, D.L.

1992-01-01

A reconnaissance geochemical survey was conducted in the southern Killik River quadrangle, central Brooks Range, northern Alaska. The Brooks Range lies within the zone of continuous permafrost which may partially inhibit chemical weathering and oxidation. The minus 30-mesh and nonmagnetic heavy-mineral concentrate fractions of sediment samples were chosen as the sample media for the survey so that mechanical rather than chemical dispersion patterns would be enhanced. A total of 263 sites were sampled within the southern half of the Killik River quadrangle at an average sample density of approximately one sample per 12 km2. All samples were submitted for multi-element analyses. In the western and central Brooks Range, several known sediment-hosted Zn-Pb-Ag(-Ba) deposits occur within a belt of Paleozoic rocks of the Endicott Mountains allochthon. Exploration for this type of deposit in the Brook Range is difficult, due to the inherently high background values for Ba, Zn and Pb in shale and the common occurrence of metamorphic quartz-calcite veins, many of which contain traces of sulfide minerals. Stream sediments derived from these sources produce numerous geochemical anomalies which are not necessarily associated with significant mineralization. R-mode factor analysis provides a means of distinguishing between element associations related to lithology and those related to possible mineralization. Factor analysis applied to the multi-element data from the southern Killik River quadrangle resulted in the discovery of two additional Zn-Pb-Ag mineral occurrences of considerable areal extent which are 80-100 km east of any previously known deposit. These have been informally named the Kady and Vidlee. Several lithogeochemical element associations, or factors, and three factors which represent sulfide mineralization were identified: Ag-Pb-Zn (galena and sphalerite) and Fe-Ni-Co-Cu (pyrite ?? chalcopyrite) in the concentrate samples and Cd-Zn-Pb-As-Mn in the sediment

On Conceptual Metaphor and the Flora and Fauna of Mind: Commentary on Brookes and Etkina; and Jeppsson, Haglund, and Amin

ERIC Educational Resources Information Center

Sherin, Bruce

2015-01-01

In this commentary, the author presents his thoughts on two papers appearing in this special issue. The first, "The Importance of Language in Students' Reasoning about Heat in Thermodynamic Processes," by David T. Brookes and Eugenia Etkina (See: EJ1060728), and the second, "Varying Use of Conceptual Metaphors Across Levels of…

Mineral soil and solution responses to experimental N and S enrichment at the Bear Brook Watershed in Maine (BBWM)

Treesearch

I. Fernandez; L. Rustad; M. David; K. Nadelhoffer; M. Mitchell

1999-01-01

Buried mineral soil-bag,, and natural solutions were studied as indicators of forest ecosystem response to elevated N and S inputs at the Bear Brook Watershed in Maine (BBWM). The BBWM is the site of a paired watershed manipulation experiment in a northern New England forested ecosystem. The study includes two small (~10 ha each) catchments dominated by northern...

Treatment Guidelines of Atrial Fibrillation (AFib or AF)

MedlinePlus

... Artery Disease Venous Thromboembolism Aortic Aneurysm More Treatment Guidelines of Atrial Fibrillation (AFib or AF) Updated:Jun 28,2017 What are the treatment guidelines for atrial fibrillation? Medical guidelines are written by ...

AfAP2-1, An Age-Dependent Gene of Aechmea fasciata, Responds to Exogenous Ethylene Treatment

PubMed Central

Lei, Ming; Li, Zhi-Ying; Wang, Jia-Bin; Fu, Yun-Liu; Ao, Meng-Fei; Xu, Li

2016-01-01

The Bromeliaceae family is one of the most morphologically diverse families with a pantropical distribution. To schedule an appropriate flowering time for bromeliads, ethylene is commonly used to initiate flower development in adult plants. However, the mechanism by which ethylene induces flowering in adult bromeliads remains unknown. Here, we identified an APETALA2 (AP2)-like gene, AfAP2-1, in Aechmea fasciata. AfAP2-1 contains two AP2 domains and is a nuclear-localized protein. It functions as a transcriptional activator, and the activation domain is located in the C-terminal region. The expression level of AfAP2-1 is higher in juvenile plants than in adult plants, and the AfAP2-1 transcript level was rapidly and transiently reduced in plants treated with exogenous ethylene. Overexpression of AfAP2-1 in Arabidopsis thaliana results in an extremely delayed flowering phenotype. These results suggested that AfAP2-1 responds to ethylene and is a putative age-dependent flowering regulator in A. fasciata. PMID:26927090

A Specific Antibody to Neuropeptide AF1 (KNEFIRFamide) Recognizes a Small Subset of Neurons in Ascaris suum: Differences from Caenorhabditis elegans

PubMed Central

Sithigorngul, Paisarn; Jarecki, Jessica L.; Stretton, Antony O.W.

2016-01-01

A monoclonal antibody, AF1-003, highly specific to the Ascaris suum neuropeptide AF1 (KNEFIRFamide), was generated. This antibody binds strongly to AF1 and extremely weakly to other peptides with C-terminal FIR-Famide: AF5 (SGKPTFIRFamide), AF6 (FIRFamide), and AF7 (AGPRFIRFamide). It does not recognize 35 other AF (A. suum FMRFamide-like) peptides at the highest concentration tested, nor does it recognize FMRFamide. When crude peptide extracts of A. suum are fractionated by two-step HPLC, the only fractions recognized by AF1-003 are those comigrating with synthetic AF1. By immunocytochemistry, antibody AF1-003 recognizes a small subset of the 298 neurons of A. suum: these include the paired URX and RIP neurons, two pairs of lateral ganglion neurons in the head, and the unpaired PQR and PDA or -B tail neurons that send processes to the head along the dorsal and ventral nerve cords, respectively. AF1 immunoreactivity is also seen in three pairs of pharyngeal neurons. Mass spectroscopy (MS) shows the presence of AF1 in the head, pharynx, and dorsal and ventral nerve cords. In A. suum, the neurons that contain AF1 show little overlap with neurons that express green fluorescent protein constructs targeting the flp-8 gene, which encodes AF1 in Caenorhabditis elegans (Kim and Li [2004] J. Comp. Neurol. 475:540– 550); the URX neurons express AF1 in both species, but, in C. elegans, flp-8 expression was not detected in RIP, PQR, and PDA or -B or in the pharynx. Other, less specific monoclonal antibodies recognize AF1, as well as other peptides to differing degrees; these antibodies are useful reagents for determination of neuronal morphology. PMID:21452223

An Evaluation of the Impacts of AF-M315E Propulsion Systems for Varied Mission Applications

NASA Technical Reports Server (NTRS)

Deans, Matthew C.; Oleson, Steven R.; Fittje, James; Colozza, Anthony; Packard, Tom; Gyekenyesi, John; McLean, Christopher H.; Spores, Ronald A.

2015-01-01

The purpose of the AF-M315E COMPASS study is to identify near-term (3-5 years) and long term (5 years +) opportunities for infusion, specifically the thruster and associated component technologies being developed as part of the GPIM project. Develop design reference missions which show the advantages of the AF-M315E green propulsion system. Utilize a combination of past COMPASS designs and selected new designs to demonstrate AF-M315E advantages. Use the COMPASS process to show the puts and takes of using AF-M315E at the integrated system level.

Effects of repeated administration of (-)-nicotine on AF64A-induced learning and memory impairment in rats.

PubMed

Hiramatsu, M; Yamatsu, T; Kameyama, T; Nabeshima, T

2002-03-01

It has been reported that pretreatment with (-)-nicotine prevents glutamate- and amyloid beta protein (Abeta)-induced cytotoxicity in vitro. However, few studies on the neuroprotective effects of (-)-nicotine in vivo have been reported. We examined whether repeated administration of (-)-nicotine exhibits neuroprotective effects in AF64A-treated rats. (-)-Nicotine (0.1 and 0.2 mg/kg, s.c.) was administered once a day for 28 days. On day 14, AF64A (2.5 nmol/side) was injected bilaterally into the hippocampus. Intrahippocampal injection of AF64A showed severe impairment of learning and memory in rats in the water maze and passive avoidance tests. Repeated administration of (-)-nicotine (0.1 and 0.2 mg/kg, s.c.) did not reverse the impairment of memory induced by AF64A in the water maze test. Interestingly, the (-)-nicotine (0.1 and 0.2 mg/kg, s.c.)-treated group showed weak impairment of learning and memory after AF64A treatment compared to the (AF64A + saline)-treated group in the passive avoidance test. These results suggested that (-)-nicotine may have neuroprotective effects against the neurotoxicity induced by AF64A.

Microfluidic Pumps Containing Teflon [Trademark] AF Diaphragms

NASA Technical Reports Server (NTRS)

Willis, Peter; White, Victor; Grunthaner, Frank; Ikeda, Mike; Mathies, Richard A.

2009-01-01

Microfluidic pumps and valves based on pneumatically actuated diaphragms made of Teflon AF polymers are being developed for incorporation into laboratory-on-a-chip devices that must perform well over temperature ranges wider than those of prior diaphragm-based microfluidic pumps and valves. Other potential applications include implanted biomedical microfluidic devices, wherein the biocompatability of Teflon AF polymers would be highly advantageous. These pumps and valves have been demonstrated to function stably after cycling through temperatures from -125 to 120 C. These pumps and valves are intended to be successors to similar prior pumps and valves containing diaphragms made of polydimethylsiloxane (PDMS) [commonly known as silicone rubber]. The PDMS-containing valves ae designed to function stably only within the temperature range from 5 to 80 C. Undesirably, PDMS membranes are somwehat porous and retain water. PDMS is especially unsuitable for use at temperatures below 0 C because the formation of ice crystals increases porosity and introduces microshear.

Simulation of groundwater flow and streamflow depletion in the Branch Brook, Merriland River, and parts of the Mousam River watersheds in southern Maine

USGS Publications Warehouse

Nielsen, Martha G.; Locke, Daniel B.

2015-01-01

The study evaluated two different methods of calculating in-stream flow requirements for Branch Brook and the Merriland River—a set of statewide equations used to calculate monthly median flows and the MOVE.1 record-extension technique used on site-specific streamflow measurements. The August median in-stream flow requirement in the Merriland River was calculated as 7.18 ft3/s using the statewide equations but was 3.07 ft3/s using the MOVE.1 analysis. In Branch Brook, the August median in-stream flow requirements were calculated as 20.3 ft3/s using the statewide equations and 11.8 ft3/s using the MOVE.1 analysis. In each case, using site-specific data yields an estimate of in-stream flow that is much lower than an estimate the statewide equations provide.

Beaver Brook, Keene, New Hampshire. Flood Damage Reduction Project. Detailed Project Report for Water Resources Development.

DTIC Science & Technology

1984-02-01

Project Report/ Environmental Assessment Beaver Brook, Keene, New Hampshire I ~ j~j~i iii ii.. A Flood Damage Reduction AD-A 14 3 376 I 𔃾, W " FEBRUARY...STATEMENT (of tme abestwee enteed to Sleok I0. Of dlfieme W booer IS. SUPPLEMENTARY MOTES 2 volume set: vol 1- Flood Damage Reduction - vol 2- Flood Damage...that are considered reasonably characteristic of the region, excluding extremely rare combinations. 2 ,4INN (0 ( w a 12 7’ PLATE * -..- ~ -- - 7 ’ k 47

Geohydrology of Brooks, Lowndes, and western Echols counties, Georgia

USGS Publications Warehouse

Krause, R.E.

1979-01-01

The principal artesian aquifer, a limestone of Eocene to Miocene age, is the main source of water supply for Brooks, Lowndes, and western Echols Counties in south Georgia. Pumpage of about 22 million gallons perday from this prolific aquifer has not posed any problems regarding declining water levels or depletion of the reservoir. However, water-quality problems do occur in the Valdosta area. Seepage-run measurements indicate that the Withlacoochee River north of Valdosta contributes an average of 112 cubic feet per second of water to caverns and sinkholes that recharge the aquifer. Wells near the recharge area withdraw relatively unfiltered water with iron concentration and color intensity exceeding standards for drinking water. South of Valdosta, water from the aquifer contains as much as 3.0 milligrams per liter of hydrogen sulfide, rendering the water unfit for drinking. Water high in sulfate concentration occurs below 550 feet in the lower part of the aquifer in Valdosta, and is assumed to be present at that depth throughout the study area. Generally, sufficient quantities of freshwater can be obtained without drilling to this depth.

Invasion by non-native brook trout in Panther Creek, Idaho: Roles of habitat quality, biotic resistance, and connectivity to source habitats

Treesearch

Joseph R. Benjamin; Jason B. Dunham; Matthew R. Dare

2007-01-01

Theoretical models and empirical evidence suggest that the invasion of nonnative species in freshwaters is facilitated through the interaction of three factors: habitat quality, biotic resistance, and connectivity. We measured variables that represented each factor to determine which were associated with the occurrence of nonnative brook trout Salvelinus...

Recognition of the 3′ splice site RNA by the U2AF heterodimer involves a dynamic population shift

PubMed Central

Voith von Voithenberg, Lena; Sánchez-Rico, Carolina; Kang, Hyun-Seo; Madl, Tobias; Zanier, Katia; Barth, Anders; Warner, Lisa R.; Sattler, Michael; Lamb, Don C.

2016-01-01

An essential early step in the assembly of human spliceosomes onto pre-mRNA involves the recognition of regulatory RNA cis elements in the 3′ splice site by the U2 auxiliary factor (U2AF). The large (U2AF65) and small (U2AF35) subunits of the U2AF heterodimer contact the polypyrimidine tract (Py-tract) and the AG-dinucleotide, respectively. The tandem RNA recognition motif domains (RRM1,2) of U2AF65 adopt closed/inactive and open/active conformations in the free form and when bound to bona fide Py-tract RNA ligands. To investigate the molecular mechanism and dynamics of 3′ splice site recognition by U2AF65 and the role of U2AF35 in the U2AF heterodimer, we have combined single-pair FRET and NMR experiments. In the absence of RNA, the RRM1,2 domain arrangement is highly dynamic on a submillisecond time scale, switching between closed and open conformations. The addition of Py-tract RNA ligands with increasing binding affinity (strength) gradually shifts the equilibrium toward an open conformation. Notably, the protein–RNA complex is rigid in the presence of a strong Py-tract but exhibits internal motion with weak Py-tracts. Surprisingly, the presence of U2AF35, whose UHM domain interacts with U2AF65 RRM1, increases the population of the open arrangement of U2AF65 RRM1,2 in the absence and presence of a weak Py-tract. These data indicate that the U2AF heterodimer promotes spliceosome assembly by a dynamic population shift toward the open conformation of U2AF65 to facilitate the recognition of weak Py-tracts at the 3′ splice site. The structure and RNA binding of the heterodimer was unaffected by cancer-linked myelodysplastic syndrome mutants. PMID:27799531

Late Mesozoic and Cenozoic thermotectonic evolution of the central Brooks Range and adjacent North Slope foreland basin, Alaska: Including fission track results from the Trans-Alaska Crustal Transect (TACT)

USGS Publications Warehouse

O'Sullivan, P. B.; Murphy, J.M.; Blythe, A.E.

1997-01-01

Apatite fission track data are used to evaluate the thermal and tectonic history of the central Brooks Range and the North Slope foreland basin in northern Alaska along the northern leg of the Trans-Alaska Crustal Transect (TACT). Fission track analyses of the detrital apatite grains in most sedimentary units resolve the timing of structures and denudation within the Brooks Range, ranging in scale from the entire mountain range to relatively small-scale folds and faults. Interpretation of the results indicates that rocks exposed within the central Brooks Range cooled rapidly from paleotemperatures 110?? to 50??C during discrete episodes at ???100??5 Ma, ???60??4 Ma, and ???24??3 Ma, probably in response to kilometer-scale denudation. North of the mountain front, rocks in the southern half of the foreland basin were exposed to maximum paleotemperatures 110??C in the Late Cretaceous to early Paleocene as a result of burial by Upper Jurassic and Cretaceous sedimentary rocks. Rapid cooling from these elevated paleotemperatures also occurred due to distinct episodes of kilometer-scale denudation at ???60??4 Ma, 46??3 Ma, 35??2 Ma, and ???24??3 Ma. Combined, the apatite analyses indicate that rocks exposed along the TACT line through the central Brooks Range and foreland basin experienced episodic rapid cooling throughout the Late Cretaceous and Cenozoic in response to at least three distinct kilometer-scale denudation events. Future models explaining orogenic events in northern Alaska must consider these new constraints from fission track thermochronology. Copyright 1997 by the American Geophysical Union.

Can the Air Force and Airlines Collaborate for Mutual Benefit An Exploration of Pilot and Maintenance Workforce Options

DTIC Science & Technology

2016-01-01

Training; Resource Management; and Strategy and Doctrine. The research reported here was prepared under contract FA7014-06-C-0001. Additional information...bankruptcies and mergers. During this period, many airline pilot groups made concessions on pay and benefits. By 2015, pay levels for major airline pilots had... Virgin America UNIQUE_CARRIER_NAME 14 Figure 8. Air Force and Commercial Maintenance Personnel Salaries NOTE: AF Annual = Air Force, enlisted. Avg

Identification and Characterization of an Antifungal Protein, AfAFPR9, Produced by Marine-Derived Aspergillus fumigatus R9.

PubMed

Rao, Qi; Guo, Wenbin; Chen, Xinhua

2015-05-01

A fungal strain, R9, was isolated from the South Atlantic sediment sample and identified as Aspergillus fumigatus. An antifungal protein, AfAFPR9, was purified from the culture supernatant of Aspergillus fumigatus R9. AfAFPR9 was identified to be restrictocin, which is a member of the ribosome-inactivating proteins (RIPs), by MALDI-TOF-TOF-MS. AfAFPR9 displayed antifungal activity against plant pathogenic Fusarium oxysporum, Alternaria longipes, Colletotrichum gloeosporioides, Paecilomyces variotii, and Trichoderma viride at minimum inhibitory concentrations of 0.6, 0.6, 1.2, 1.2, and 2.4 μg/disc, respectively. Moreover, AfAFPR9 exhibited a certain extent of thermostability, and metal ion and denaturant tolerance. The iodoacetamide assay showed that the disulfide bridge in AfAFPR9 was indispensable for its antifungal action. The cDNA encoding for AfAFPR9 was cloned from A. fumigatus R9 by RTPCR and heterologously expressed in E. coli. The recombinant AfAFPR9 protein exhibited obvious antifungal activity against C. gloeosporioides, T. viride, and A. longipes. These results reveal the antifungal properties of a RIP member (AfAFPR9) from marine-derived Aspergillus fumigatus and indicated its potential application in controlling plant pathogenic fungi.

The effects of low-speed swimming following exhaustive exercise on metabolic recovery and swimming performance in brook trout (Salvelinus fontinalis).

PubMed

Kieffer, James D; Kassie, Roshini S; Taylor, Susan G

2011-01-01

Experiments were conducted to determine whether low-speed swimming during recovery from exhaustive exercise improved both metabolic recovery and performance during a swimming challenge. For these experiments, brook trout were allowed to recover from exhaustive exercise for 2 h while swimming at 0, 0.5, 1.0, or 1.5 body length (BL) s(-1) or allowed to recover from exhaustive exercise for 1, 2, or 3 h while swimming at 1.0 BL s(-1). At the appropriate interval, either (i) muscle and blood samples were removed from the fish or (ii) fish were assessed for performance (i.e., fatigue time) during a fixed-interval swimming test. Low-speed swimming during recovery from exhaustive exercise resulted in significantly longer fatigue times compared with fish recovering in still water (i.e., 0 BL s(-1)). However, swimming during recovery did not expedite recovery of muscle lactate or blood variables (e.g., lactate, osmolarity, glucose). These observations suggest that metabolic recovery and subsequent swimming performance may not be directly linked and that other factors play a role in swimming recovery in brook trout.

Cough response and uptake of mercury by Brook trout, Salvelinus fontinalis, exposed to mercuric compounds at different hydrogen-ion concentrations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Drummond, R.A.; Olson, G.F.; Battermna, A.R.

1974-01-01

The lowest concentration of methylmercuric chloride (MMC) and mercuric chloride added to Lake Superior water that caused a significant increase in cough frequency in Brook trout was 3 micrograms Hg/liter. Cough frequency is a good short-term indicator of the long-term effects of MMC. The response can be used to predict the safe concentration of mercuric chloride since the long-term effects of the compound are not known. Increases in cough frequency were proportional to the concentration (from 3 to 12 micrograms Hg/liter) of both compounds at pH 7.5. The fish were more responsive to MMC when the pH of the testmore » water was lowered to 6.0; response to mercuric chloride was not changed by lowered pH. Fish exposed to MMC at pH 6.0 contained more total mercury in their gills and red blood cells than fish tested at pH 9.0. The uptake of mercury by brook trout exposed to mercuric chloride did not differ significantly at pH 6.0 and 9.0.« less

Higher risk of death and stroke in patients with persistent vs. paroxysmal atrial fibrillation: results from the ROCKET-AF Trial.

PubMed

Steinberg, Benjamin A; Hellkamp, Anne S; Lokhnygina, Yuliya; Patel, Manesh R; Breithardt, Günter; Hankey, Graeme J; Becker, Richard C; Singer, Daniel E; Halperin, Jonathan L; Hacke, Werner; Nessel, Christopher C; Berkowitz, Scott D; Mahaffey, Kenneth W; Fox, Keith A A; Califf, Robert M; Piccini, Jonathan P

2015-02-01

Anticoagulation prophylaxis for stroke is recommended for at-risk patients with either persistent or paroxysmal atrial fibrillation (AF). We compared outcomes in patients with persistent vs. paroxysmal AF receiving oral anticoagulation. Patients randomized in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET-AF) trial (n = 14 264) were grouped by baseline AF category: paroxysmal or persistent. Multivariable adjustment was performed to compare thrombo-embolic events, bleeding, and death between groups, in high-risk subgroups, and across treatment assignment (rivaroxaban or warfarin). Of 14 062 patients, 11 548 (82%) had persistent AF and 2514 (18%) had paroxysmal AF. Patients with persistent AF were marginally older (73 vs. 72, P = 0.03), less likely female (39 vs. 45%, P < 0.0001), and more likely to have previously used vitamin K antagonists (64 vs. 56%, P < 0.0001) compared with patients with paroxysmal AF. In patients randomized to warfarin, time in therapeutic range was similar (58 vs. 57%, P = 0.94). Patients with persistent AF had higher adjusted rates of stroke or systemic embolism (2.18 vs. 1.73 events per 100-patient-years, P = 0.048) and all-cause mortality (4.78 vs. 3.52, P = 0.006). Rates of major bleeding were similar (3.55 vs. 3.31, P = 0.77). Rates of stroke or systemic embolism in both types of AF did not differ by treatment assignment (rivaroxaban vs. warfarin, Pinteraction = 0.6). In patients with AF at moderate-to-high risk of stroke receiving anticoagulation, those with persistent AF have a higher risk of thrombo-embolic events and worse survival compared with paroxysmal AF. © The Author 2014. Published by Oxford University Press on behalf of the European Society of Cardiology.

Higher risk of death and stroke in patients with persistent vs. paroxysmal atrial fibrillation: results from the ROCKET-AF Trial

PubMed Central

Steinberg, Benjamin A.; Hellkamp, Anne S.; Lokhnygina, Yuliya; Patel, Manesh R.; Breithardt, Günter; Hankey, Graeme J.; Becker, Richard C.; Singer, Daniel E.; Halperin, Jonathan L.; Hacke, Werner; Nessel, Christopher C.; Berkowitz, Scott D.; Mahaffey, Kenneth W.; Fox, Keith A.A.; Califf, Robert M.; Piccini, Jonathan P.

2015-01-01

Aim Anticoagulation prophylaxis for stroke is recommended for at-risk patients with either persistent or paroxysmal atrial fibrillation (AF). We compared outcomes in patients with persistent vs. paroxysmal AF receiving oral anticoagulation. Methods and results Patients randomized in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET-AF) trial (n = 14 264) were grouped by baseline AF category: paroxysmal or persistent. Multivariable adjustment was performed to compare thrombo-embolic events, bleeding, and death between groups, in high-risk subgroups, and across treatment assignment (rivaroxaban or warfarin). Of 14 062 patients, 11 548 (82%) had persistent AF and 2514 (18%) had paroxysmal AF. Patients with persistent AF were marginally older (73 vs. 72, P = 0.03), less likely female (39 vs. 45%, P < 0.0001), and more likely to have previously used vitamin K antagonists (64 vs. 56%, P < 0.0001) compared with patients with paroxysmal AF. In patients randomized to warfarin, time in therapeutic range was similar (58 vs. 57%, P = 0.94). Patients with persistent AF had higher adjusted rates of stroke or systemic embolism (2.18 vs. 1.73 events per 100-patient-years, P = 0.048) and all-cause mortality (4.78 vs. 3.52, P = 0.006). Rates of major bleeding were similar (3.55 vs. 3.31, P = 0.77). Rates of stroke or systemic embolism in both types of AF did not differ by treatment assignment (rivaroxaban vs. warfarin, Pinteraction = 0.6). Conclusion In patients with AF at moderate-to-high risk of stroke receiving anticoagulation, those with persistent AF have a higher risk of thrombo-embolic events and worse survival compared with paroxysmal AF. PMID:25209598

Limited hatchery introgression into wild brook trout (Salvelinus fontinalis) populations despite reoccurring stocking

USGS Publications Warehouse

White, Shannon L.; Miller, William L.; Dowell, Stephanie A.; Bartron, Meredith L.; Wagner, Tyler

2018-01-01

Due to increased anthropogenic pressures on many fish populations, supplementing wild populations with captive‐raised individuals has become an increasingly common management practice. Stocking programs can be controversial due to uncertainty about the long‐term fitness effects of genetic introgression on wild populations. In particular, introgression between hatchery and wild individuals can cause declines in wild population fitness, resiliency, and adaptive potential, and contribute to local population extirpation. However, low survival and fitness of captive‐raised individuals can minimize the long‐term genetic consequences of stocking in wild populations, and to date the prevalence of introgression in actively stocked ecosystems has not been rigorously evaluated. We quantified the extent of introgression in 30 populations of wild brook trout (Salvelinus fontinalis) in a Pennsylvania watershed, and examined the correlation between introgression and 11 environmental covariates. Genetic assignment tests were used to determine the origin (wild vs. captive‐raised) for 1742 wild‐caught and 300 hatchery brook trout. To avoid assignment biases, individuals were assigned to two simulated populations that represented the average allele frequencies in wild and hatchery groups. Fish with intermediate probabilities of wild ancestry were classified as introgressed, with threshold values determined through simulation. Even with reoccurring stocking at most sites, over 93% of wild‐caught individuals probabilistically assigned to wild origin, and only 5.6% of wild‐caught fish assigned to introgressed. Models examining environmental drivers of introgression explained less than 3% of the among‐population variability, and all estimated effects were highly uncertain. This was not surprising given overall low introgression observed in this study. Our results suggest that introgression of hatchery‐derived genotypes can occur at low rates, even in actively stocked

Activation function 2 (AF2) of estrogen receptor-α is required for the atheroprotective action of estradiol but not to accelerate endothelial healing

PubMed Central

Billon-Galés, Audrey; Krust, Andrée; Fontaine, Coralie; Abot, Anne; Flouriot, Gilles; Toutain, Céline; Berges, Hortense; Gadeau, Alain-Pierre; Lenfant, Françoise; Gourdy, Pierre; Chambon, Pierre; Arnal, Jean-François

2011-01-01

17β-Estradiol (E2) regulates estrogen receptor-α (ERα) target gene transcription through the two independent activation functions (AFs), AF1 and AF2, located in the N-terminal and ligand binding domain of ERα, respectively. We previously reported that ERα is required for the E2 atheroprotective action as well as for its accelerative action on endothelial healing, but its AF1 function is dispensable. Here, we investigated the role of ERαAF2 in these two major beneficial actions of E2 by electively targeting ERαAF2 (named ERαAF20). Our results prove four points. (i) Compared with WT ERα, the ability of ERαAF20 to stimulate the C3 complement or the estrogen response element-thymidine kinase promoter in two cell lines was dramatically decreased, confirming the importance of AF2 in the E2-induced transcriptional activity of ERα. (ii) The uterotrophic action of E2 was totally absent in ERαAF20 mice, showing the crucial role of ERαAF2 in E2-induced uterus hyperplasia. (iii) ERαAF2 was dispensable for the accelerative action of E2 on endothelial healing, underlining the functionality of ERαAF20 in vivo. (iv) Finally, the atheroprotective effect of E2 was abrogated in ERαAF20 LDL-r−/− mice. Thus, whereas ERαAF1 and ERαAF2 are both required for the uterotrophic action of E2, we show that only ERαAF2 is necessary for its atheroprotective effect. PMID:21788522

Health assessment for Welsh Road/Barkman Landfill, Honey Brook, Chester County, Pennsylvania, Region 3. CERCLIS No. PAD980829527. Preliminary report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1988-12-02

The Welsh Road/Barkman Landfill site in Honey Brook, Pennsylvania was an unpermitted residential and commercial refuse disposal facility that operated from 1963 to sometime in the 1980s. After 1977, the landfill continued to operate in defiance of legal action to support a closure plan. Various investigations conducted in the 1980s revealed that industrial and hazardous waste had been accepted by the site. The environmental contamination on-site consists of copper, lead, 1,2-dichloropropane, toluene, chloroform and methylene chloride in drummed wastes; and mercury, toluene, dichlorofluoromethane, methylene chloride, trichlorofluoromethane, 5-methyl-2-hexanone, trichloroethylene, 1,2-dichloroethane, and 1,3,5-cycloheptatriene in groundwater. One time sampling indicated the presence ofmore » volatile compounds in air (hydrogen chloride and chloroform). The environmental contamination off-site consists of cadmium in sediment; and chloromethane, chloroform, xylenes, dichlorofluoromethane, 1,1-dichloroethane, tetrachloroethylene, p-cresol, toluene, methyl isobutyl ketone, di-n-butyl phthalate, lead, mercury, and zinc in residential well water. The site is considered to be of potential public health concern because of the risk to human health caused by the possibility of exposure to hazardous substances via contaminated groundwater, surface water, soil, sediment, and airborne gases, vapors, and particulate.« less

Measuring Teachers' Assessment for Learning (AfL) Classroom Practices in Elementary Schools

ERIC Educational Resources Information Center

Lysaght, Zita; O'Leary, Michael; Ludlow, Larry

2017-01-01

Assessment for Learning (AfL) may be conceptualized as minute-to-minute, day-by-day interactions between learners and teachers with the improvement of learning as the principal focus. This paper traces the development of an AfL measurement instrument (scale) that can be used for research purposes prior to, during and following professional…

Head-space, small-chamber and in-vehicle tests for volatile organic compounds (VOCs) emitted from air fresheners for the Korean market.

PubMed

Jo, Wan-Kuen; Lee, Jong-Hyo; Kim, Mo-Keun

2008-02-01

The present study investigated the emission characteristics of gel-type air fresheners (AFs), using head-space, small-chamber, and in-vehicle tests. Five toxic or hazardous analytes were found in the headspace phase of AFs (toluene, benzene, ethyl benzene, and m,p-xylene) at a frequency of more than 50%. Limonene and linalool, which are known to be unsaturated ozone-reactive VOCs, were detected at a frequency of 58 and 35%, respectively. The empirical model fitted well with the time-series concentrations in the chamber, thereby suggesting that the empirical model was suitable for testing emissions. Limonene exhibited the highest emission rate, followed by m,p-xylene, toluene, ethyl benzene, and benzene. For most target VOCs, higher air change per hour (ACH) levels exhibited increased emission rates. In contrast, higher ACH levels resulted in lower chamber concentrations. The mean concentration of limonene was significantly higher in passenger cars with an AF than without. For other target compounds, there were no significant differences between the two conditions tested. Consequently, it was suggested that unlike limonene, the emission strength for aromatic compounds identified in the chamber tests was not strong enough to elevate in-vehicle levels.

Final Environmental Assessment: Addressing Construction of a New Civil Engineering Workshop at Bellows Air Force Station, O’ahu, Hawaii

DTIC Science & Technology

2010-03-01

FINAL ENVIRONMENTAL ASSESSMENT ADDRESSING CONSTRUCTION OF A NEW CIVIL ENGINEERING WORKSHOP AT BELLOWS AIR FORCE STATION , O‘AHU, HAWAI‘I...Minimize impacts on other Bellows AFS functions and environmental resources This alternative would be located in an area located near Building 546 and...Preparation of An Environmental Assessment for the Proposed Construction of New Civil Engineering Workshop at Bellows Air !Force Station Thank you

Predictors of arrhythmia recurrence after balloon cryoablation of atrial fibrillation: the value of CAAP-AF risk scoring system.

PubMed

Sanhoury, Mohamed; Moltrasio, Massimo; Tundo, Fabrizio; Riva, Stefania; Dello Russo, Antonio; Casella, Michela; Tondo, Claudio; Fassini, Gaetano

2017-08-01

In the present study, we aimed to test the value of CAAP-AF score for prediction of atrial fibrillation (AF) recurrence at follow-up in a group of our patients treated by balloon cryoablation. A total of 283 symptomatic drug-refractory AF patients [261 (92%) with paroxysmal AF] who underwent pulmonary vein isolation (PVI) with second-generation cryoballoon between April 2012 and October 2016 were included. The CAAP-AF score was calculated for every patient. A total of 283 patients [68 female (20%), mean age 59.8 ± 11.4 years] were included in the present analysis. Eighty-nine patients (31%) had hypertension and 13 (4%) had coronary artery disease. The mean left atrial diameter and left ventricular ejection fraction were 40.6 ± 7.0 mm and 60.0 ± 9.1%, respectively. The mean CHA 2 DS 2 -VASc score was 1.2 ± 1.1, and mean number of prior failed antiarrhythmic drugs was 1.4 ± 0.8. At 18 ± 6 months follow-up, 25 patients (8.87%) developed AF recurrence. The recurrence rate was as follows: 3.17% (score 0-3), 8.47% (score 4), 16.28% (score 5), 6.67% (score 6), 23.08% (score 7), and 36.36% (score ≥8). The recurrence rate was 4.86% at a score <5 and 16.49% at a value ≥5; a score cutoff ≥5 predicted AF recurrence with a sensitivity 64% and specificity 68%. The present analysis suggests the usefulness of CAAP-AF scoring system, with its simple and easily obtained six clinical variables, to predict AF recurrence after PVI by means of second-generation cryoballoon. A score value ≥5 predicted AF recurrence with a sensitivity 64% and specificity 68%.

Air Force Systems Engineering Assessment Model (AF SEAM) Management Guide, Version 2

DTIC Science & Technology

2010-09-21

gleaned from experienced professionals who assisted with the model’s development. Examples of the references used include the following: • ISO /IEC...Defense Acquisition Guidebook, Chapter 4 • AFI 63-1201, Life Cycle Systems Engineering • IEEE/EIA 12207 , Software Life Cycle Processes • Air...Selection criteria Reference Material: IEEE/EIA 12207 , MIL-HDBK-514 Other Considerations: Modeling, simulation and analysis techniques can be

Baseline Demographics, Safety, and Patient Acceptance of an Insertable Cardiac Monitor for Atrial Fibrillation Screening: The REVEAL-AF Study.

PubMed

Conti, Sergio; Reiffel, James A; Gersh, Bernard J; Kowey, Peter R; Wachter, Rolf; Halperin, Jonathan L; Kaplon, Rachelle E; Pouliot, Erika; Verma, Atul

2017-01-01

Given the high prevalence and risk of stroke associated with atrial fibrillation (AF), detection strategies have important public health implications. The ongoing prospective, single-arm, open-label, multicenter REVEAL AF trial is evaluating the incidence of previously undetected AF using an insertable cardiac monitor (ICM) in patients without prior AF or device implantation, but who could be at risk for AF due to their demographic characteristics, +/- non-specific but compatible symptoms. Enrollment required an elevated AF risk profile defined as CHADS2≥3 or CHADS 2 =2 plus one or more of the following: coronary artery disease, renal impairment, sleep apnea or chronic obstructive pulmonary disease. Exclusions included stroke or transient ischemic attack occurring in the previous year. Of 450 subjects screened, 399 underwent a device insertion attempt, and 395 were included in the final analysis (Reveal XT: n=122; Reveal LINQ: n=273; excluded: n=4). Participants were primarily identified by demographic characteristics and the presence of nonspecific symptoms, but without prior documentation of "overt" AF. The most common symptoms were palpitations (51%), dizziness/lightheadedness/pre-syncope (36%), and shortness of breath (36%). Over 100 subjects were enrolled in each pre-defined CHADS2 subgroup (2, 3 and ≥4). AF risk factors not included in the CHADS2 score were well represented (prevalence≥15%). Procedure and/or device related serious adverse events were low, with the miniaturized Reveal LINQ ICM having a more favorable safety profile than the predicate Reveal XT (all: n=13 [3.3%]; LINQ: n=6 [2.2%]; XT: n=7 [5.7%]). These data demonstrate that REVEAL AF was successful in enrolling its target population, high risk patients were willing to undergo ICM monitoring for AF screening, and ICM use in this group is becoming increasingly safe with advancements in technology. A clinically meaningful incidence of device detected AF in this study will inform clinical

Psychological Issues Relevant to Astronaut Selection for Long-Duration Space Flight: A Review of the Literature

DTIC Science & Technology

1985-04-01

orbital bases in the future involving 10 to 20 people (Schlitz, 1983). Subject availability and other practical considerations have discouraged...InA By NDaniel L. Collins, Capt, USAF MANPOWER AND PERSONNEL DIVISION Brooks Air Force Base , Texas 78235-5601 R DTICAELECTE11 E MrDAY 2 2 05 S April...SYSTEMS COMMAND BROOKS AIR FORCE BASE , TEXAS 78235-5000 8 s 04 29 1o4 NOTICE When Government drawings, specifications, or other data are used for any

Assessing the effects of catch and release regulations on a quality adfluvial brook trout population using a computer based age-structure model

USGS Publications Warehouse

Risley, Casey A.L.; Zydlewski, Joseph D.

2011-01-01

Assessing the Effects of Catch-and-Release Regulations on a Brook Trout Population Using an Age-Structured Model: North American Journal of Fisheries Management: Vol 30, No 6 var _prum=[['id','54ff88bcabe53dc41d1004a5'],['mark','firstbyte',(new Date()).getTime()

United States Air Force Statistical Digest, Fiscal Year 1959. Fourteenth Edition

DTIC Science & Technology

1959-09-30

Support Forces for fiscal year 1959 consist of Air Refueling; Strategic Support; Airborne Early Warning and Control; Radar Evaluation ;.He11cop~er...missions. (EI) Test: Aircraft assigned to evaluate the aircraft and/or its components installed as standard equipment. (EH) Test Support: Aircraft... consumables under two AF-GEN sub-projects: PROJECT SEAWEED and PROJECT NIGHT LIFE & FLYAWAY KITS. Also included in this section is data on ammunition

AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis.

PubMed

Park, Jino; Schlederer, Michaela; Schreiber, Martin; Ice, Ryan; Merkel, Olaf; Bilban, Martin; Hofbauer, Sebastian; Kim, Soojin; Addison, Joseph; Zou, Jie; Ji, Chunyan; Bunting, Silvia T; Wang, Zhengqi; Shoham, Menachem; Huang, Gang; Bago-Horvath, Zsuzsanna; Gibson, Laura F; Rojanasakul, Yon; Remick, Scot; Ivanov, Alexey; Pugacheva, Elena; Bunting, Kevin D; Moriggl, Richard; Kenner, Lukas; Tse, William

2015-08-21

AF1q is an MLL fusion partner that was identified from acute myeloid leukemia (AML) patients with t (1; 11) (q21; q23) chromosomal abnormality. The function of AF1q is not yet fully known, however, elevated AF1q expression is associated with poor clinical outcomes in various malignancies. Here, we show that AF1q specifically binds to T-cell-factor-7 (TCF7) in the Wnt signaling pathway and results in transcriptional activation of CD44 as well as multiple downstream targets of the TCF7/LEF1. In addition, enhanced AF1q expression promotes breast cancer cell proliferation, migration, mammosphere formation, and chemo-resistance. In xenograft models, enforced AF1q expression in breast cancer cells also promotes liver metastasis and lung colonization. In a cohort of 63 breast cancer patients, higher percentages of AF1q-positive cancer cells in primary sites were associated with significantly poorer overall survival (OS), disease-free survival (DFS), and brain metastasis-free survival (b-MFS). Using paired primary/metastatic samples from the same patients, we demonstrate that AF1q-positive breast cancer cells become dynamically dominant in the metastatic sites compared to the primary sites. Our findings indicate that breast cancer cells with a hyperactive AF1q/TCF7/CD44 regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties.

History of Air Force Operational Test and Evaluation (OT and E) Mission, Organization, and Policy

DTIC Science & Technology

1992-12-01

which also observed that "the decisive factor in the war with Iraq was the air campaign." DoD’s Gulf War report also noted the "extraordinary...and Air Warfare: Training and Testing at Eglin in World War II," in William S. Coker (ed.), The Military Presence on the Gulf Coast (Pensacola, FL...34Test and Evaluation," 12 May 72. 35. Hist of AF/XOOW, Jan-Jim 73. 36. US General Accounting Office, "Statement of Elmer B. Staats , Comptroller

High temperature dielectric properties of Apical, Kapton, Peek, Teflon AF, and Upilex polymers

NASA Technical Reports Server (NTRS)

Hammoud, A. N.; Baumann, E. D.; Overton, E.; Myers, I. T.; Suthar, J. L.; Khachen, W.; Laghari, J. R.

1992-01-01

Reliable lightweight systems capable of providing electrical power at the magawatt level are a requirement for future manned space exploration missions. This can be achieved by the development of high temperature insulating materials which are not only capable of surviving the hostile space environment but can contribute to reducing the mass and weight of the heat rejection system. In this work, Apical, Upilex, Kapton, Teflon AF, and Peek polymers are characterized for AC and DC dielectric breakdown in air and in silicone oil at temperatures up to 250 C. The materials are also tested in terms of their dielectric constant and dissipation factor at high temperatures with an electrical stress of 60 Hz, 200 V/mil present. The effects of thermal aging on the properties of the films are determined after 15 hours of exposure to 200 and 250 C, each. The results obtained are discussed and conclusions are made concerning the suitability of these dielectrics for use in capacitors and cable insulations in high temperature environments.

High temperature dielectric properties of Apical, Kapton, Peek, Teflon AF, and Upilex polymers

NASA Astrophysics Data System (ADS)

Hammoud, A. N.; Baumann, E. D.; Overton, E.; Myers, I. T.; Suthar, J. L.; Khachen, W.; Laghari, J. R.

1992-06-01

Reliable lightweight systems capable of providing electrical power at the magawatt level are a requirement for future manned space exploration missions. This can be achieved by the development of high temperature insulating materials which are not only capable of surviving the hostile space environment but can contribute to reducing the mass and weight of the heat rejection system. In this work, Apical, Upilex, Kapton, Teflon AF, and Peek polymers are characterized for AC and DC dielectric breakdown in air and in silicone oil at temperatures up to 250 C. The materials are also tested in terms of their dielectric constant and dissipation factor at high temperatures with an electrical stress of 60 Hz, 200 V/mil present. The effects of thermal aging on the properties of the films are determined after 15 hours of exposure to 200 and 250 C, each. The results obtained are discussed and conclusions are made concerning the suitability of these dielectrics for use in capacitors and cable insulations in high temperature environments.

The Air Force's central reference laboratory: maximizing service while minimizing cost.

PubMed

Armbruster, D A

1991-11-01

The Laboratory Services Branch (Epi Lab) of the Epidemiology Division, Brooks AFB, Texas, is designated by regulation to serve as the Air Force's central reference laboratory, providing clinical laboratory testing support to all Air Force medical treatment facilities (MTFs). Epi Lab recognized that it was not offering the MTFs a service comparable to civilian reference laboratories and that, as a result, the Air Force medical system was spending hundreds of thousands of dollars yearly for commercial laboratory support. An in-house laboratory upgrade program was proposed to and approved by the USAF Surgeon General, as a Congressional Efficiencies Add project, to launch a two-phase initiative consisting of a 1-year field trial of 30 MTFs, followed by expansion to another 60 MTFs. Major components of the program include overnight air courier service to deliver patient samples to Epi Lab, a mainframe computer laboratory information system and electronic reporting of results to the MTFs throughout the CONUS. Application of medical marketing concepts and the Total Quality Management (TQM) philosophy allowed Epi to provide dramatically enhanced reference service at a cost savings of about $1 million to the medical system. The Epi Lab upgrade program represents an innovative problem-solving approach, combining technical and managerial improvements, resulting in substantial patient care service and financial dividends. It serves as an example of successful application of TQM and marketing within the military medical system.

Physical, chemical, and isotopic data from groundwater in the watershed of Mirror Lake, and in the vicinity of Hubbard Brook, near West Thornton, New Hampshire, 1983 to 1997

USGS Publications Warehouse

LaBaugh, James W.; Harte, Philip T.; Shapiro, Allen M.; Hsieh, Paul A.; Johnson, Carole D.; Goode, Daniel J.; Wood, Warren W.; Buso, Donald C.; Likens, Gene E.; Winter, Thomas C.

2013-01-01

Research on the hydrogeologic setting of Mirror Lake near West Thornton, New Hampshire (43° 56.5’ N, 71° 41.5’ W), includes the study of the physical, chemical, and isotopic characteristics of groundwater in the vicinity of the lake and nearby Hubbard Brook. Presented here are those physical, chemical, and isotopic data for the period 1983 to 1997. Data were collected from observation wells installed in glacial drift and bedrock, as well as from one domestic well in the general area of the lake and Hubbard Brook. Also presented are data for Mirror Lake for August 1, 1993, to place groundwater data in context with chemical and isotopic characteristics of the lake.

A Strong Independent Community College for the District of Columbia. Testimony of Alice M. Rivlin, Senior Fellow and Director of Greater Washington Research at the Brookings Institution, before the Council of the District of Columbia Committee of the Whole Community College Roundtable

ERIC Educational Resources Information Center

Rivlin, Alice M.

2009-01-01

In this testimony, the author talks briefly about how the District of Columbia Appleseed and her organization, Greater Washington Research at Brookings, came to sponsor the community college feasibility study they have released. In 2008, both Brookings and DC Appleseed published papers highlighting the importance of providing opportunities for DC…

Behavioural Thermoregulatory Tactics in Lacustrine Brook Charr, Salvelinus fontinalis

PubMed Central

Bertolo, Andrea; Pépino, Marc; Adams, Julie; Magnan, Pierre

2011-01-01

The need to vary body temperature to optimize physiological processes can lead to thermoregulatory behaviours, particularly in ectotherms. Despite some evidence of within-population phenotypic variation in thermal behaviour, the occurrence of alternative tactics of this behaviour is rarely explicitly considered when studying natural populations. The main objective of this study was to determine whether different thermal tactics exist among individuals of the same population. We studied the behavioural thermoregulation of 33 adult brook charr in a stratified lake using thermo-sensitive radio transmitters that measured hourly individual temperature over one month. The observed behavioural thermoregulatory patterns were consistent between years and suggest the existence of four tactics: two “warm” tactics with both crepuscular and finer periodicities, with or without a diel periodicity, and two “cool” tactics, with or without a diel periodicity. Telemetry data support the above findings by showing that the different tactics are associated with different patterns of diel horizontal movements. Taken together, our results show a clear spatio-temporal segregation of individuals displaying different tactics, suggesting a reduction of niche overlap. To our knowledge, this is the first study showing the presence of behavioural thermoregulatory tactics in a vertebrate. PMID:21490935

Habitat suitability index model for brook trout in streams of the Southern Blue Ridge Province: surrogate variables, model evaluation, and suggested improvements

Treesearch

Christoper J. Schmitt; A. Dennis Lemly; Parley V. Winger

1993-01-01

Data from several sources were collated and analyzed by correlation, regression, and principal components analysis to define surrrogate variables for use in the brook trout (Salvelinus fontinalis) habitat suitability index (HSI) model, and to evaluate the applicability of the model for assessing habitat in high elevation streams of the southern Blue Ridge Province (...

Design and position control of AF lens actuator for mobile phone using IPMC-EMIM

NASA Astrophysics Data System (ADS)

Kim, Sung-Joo; Kim, Chul-Jin; Park, No-Cheol; Yang, Hyun-Seok; Park, Young-Pil; Park, Kang-Ho; Lee, Hyung-Kun; Choi, Nak-Jin

2008-03-01

IPMC-EMIM (Ionic Polyer Metal Composites + 1-ethyl-3- methyl imidazolium trifluromethane sulfonate, EMIM-Tfo) is fabricated by substituting ionic liquid for water in Nafion film, which improves water sensitiveness of IPMC and guarantees uniform performance regardless of the surrounding environment. In this paper, we will briefly introduce the procedure of fabrication of IPMC-EMIM and proceed to introduce the Hook-type actuator using IPMC-EMIM and application to AF Lens actuator. Parameters of Hook-type actuator are estimated from experimental data. In the simulation, The proposed AF Lens Actuator is assumed to be a linear system and based on estimated parameters, PID controller will be designed and controlled motion of AF Lens actuator will be shown through simulation.

A simple web-based tool to compare freshwater fish data collected using AFS standard methods

USGS Publications Warehouse

Bonar, Scott A.; Mercado-Silva, Norman; Rahr, Matt; Torrey, Yuta T.; Cate, Averill

2016-01-01

The American Fisheries Society (AFS) recently published Standard Methods for Sampling North American Freshwater Fishes. Enlisting the expertise of 284 scientists from 107 organizations throughout Canada, Mexico, and the United States, this text was developed to facilitate comparisons of fish data across regions or time. Here we describe a user-friendly web tool that automates among-sample comparisons in individual fish condition, population length-frequency distributions, and catch per unit effort (CPUE) data collected using AFS standard methods. Currently, the web tool (1) provides instantaneous summaries of almost 4,000 data sets of condition, length frequency, and CPUE of common freshwater fishes collected using standard gears in 43 states and provinces; (2) is easily appended with new standardized field data to update subsequent queries and summaries; (3) compares fish data from a particular water body with continent, ecoregion, and state data summaries; and (4) provides additional information about AFS standard fish sampling including benefits, ongoing validation studies, and opportunities to comment on specific methods. The web tool—programmed in a PHP-based Drupal framework—was supported by several AFS Sections, agencies, and universities and is freely available from the AFS website and fisheriesstandardsampling.org. With widespread use, the online tool could become an important resource for fisheries biologists.

Air Force Human Resources Laboratory Annual Report Fiscal Year 1984,

DTIC Science & Technology

1985-07-01

Wilbourn AFHRL/MOAE AFHRL/MOAE Brooks AFB, TX 78235-5000 Brooks AFB, TX 78235-5000 Commercial (512) 536-3256 Commercial (512) 536-3256 AUTOVON 240-3256...the-job training. Dr Joseph Yasutake Technical Advisor 142 .-m -- m Immmm ..jmmmmm mm mmmmmmm1mm n m COMMAND STAFF PERSONNEL - e Mr. Robert L. lady...initial big-step improvements can be made. The subthrusts have been the subject of unusually Lt Col Joseph A. Dirt high-level interest. Special scientific

Restoration of the Hypersonic Tunnel Facility at NASA Glenn Research Center, Plum Brook Station

NASA Technical Reports Server (NTRS)

Woodling, Mark A.

2000-01-01

The NASA Glenn Research Center's Hypersonic Tunnel Facility (HTF), located at the Plum Brook Station in Sandusky, Ohio, is a non-vitiated, free-jet facility, capable of testing large-scale propulsion systems at Mach Numbers from 5 to 7. As a result of a component failure in September of 1996, a restoration project was initiated in mid- 1997 to repair the damage to the facility. Following the 2-1/2 year effort, the HTF has been returned to an operational condition. Significant repairs and operational improvements have been implemented in order to ensure facility reliability and personnel safety. As of January 2000, this unique, state-of-the-art facility was ready for integrated systems testing.

Development of a Design Tool for Planning Aqueous Amendment Injection Systems

DTIC Science & Technology

2008-06-01

BIOREMresources.asp) • “Protocol for Enhanced In Situ Bioremediation Using Emulsified Edible Oil” – (search for title at http://docs.serdp-estcp.org...index.cfm) • “Protocol for In Situ Bioremediation of Chlorinated Solvents Using Edible Oil” (http://www.afcee.brooks.af.mil/products/techtrans...and acetate by common subsurface microorganisms . The H2 and acetate are then used as a carbon and energy source for anaerobic biodegradation of the

Stroke prevention in atrial fibrillation and 'real world' adherence to guidelines in the Balkan Region: The BALKAN-AF Survey.

PubMed

Potpara, Tatjana S; Dan, Gheorghe-Andrei; Trendafilova, Elina; Goda, Artan; Kusljugic, Zumreta; Manola, Sime; Music, Ljilja; Musetescu, Rodica; Badila, Elisabeta; Mitic, Gorana; Paparisto, Vilma; Dimitrova, Elena S; Polovina, Marija M; Petranov, Stanislav L; Djergo, Hortensia; Loncar, Daniela; Bijedic, Amira; Brusich, Sandro; Lip, Gregory Y H

2016-02-12

Data on the management of atrial fibrillation (AF) in the Balkan Region are limited. The Serbian AF Association (SAFA) prospectively investigated contemporary 'real-world' AF management in clinical practice in Albania, Bosnia&Herzegovina, Bulgaria, Croatia, Montenegro, Romania and Serbia through a 14-week (December 2014-February 2015) prospective, multicentre survey of consecutive AF patients. We report the results pertinent to stroke prevention strategies. Of 2712 enrolled patients, 2663 (98.2%) with complete data were included in this analysis (mean age 69.1 ± 10.9 years, female 44.6%). Overall, 1960 patients (73.6%) received oral anticoagulants (OAC) and 762 (28.6%) received antiplatelet drugs. Of patients given OAC, 17.2% received non-vitamin K antagonist oral anticoagulants (NOACs). CHA2DS2-VASc score was not significantly associated with OAC use. Of the 'truly low-risk' patients (CHA2DS2-VASc = 0 [males], or 1 [females]) 56.5% received OAC. Time in Therapeutic Range (TTR) was available in only 18.7% of patients (mean TTR: 49.5% ± 22.3%). Age ≥ 80 years, prior myocardial infarction and paroxysmal AF were independent predictors of OAC non-use. Our survey shows a relatively high overall use of OAC in AF patients, but with low quality of vitamin K antagonist therapy and insufficient adherence to AF guidelines. Additional efforts are needed to improve AF-related thromboprophylaxis in clinical practice in the Balkan Region.

An inverted metamorphic field gradient in the central Brooks Range, Alaska and implications for exhumation of high-pressure/low-temperature metamorphic rocks

USGS Publications Warehouse

Patrick, B.; Till, A.B.; Dinklage, W.S.

1994-01-01

During exhumation of the Brooks Range internal zone, amphibolite-facies rocks were emplaced atop the blueschist/greenschist facies schist belt. The resultant inverted metamorphic field gradient is mappable as a series of isograds encountered as one traverses up structural section. Amphibolite-facies metamorphism occurred at ??? 110 Ma as determined from 40Ar 39Ar analysis of hornblende. This contrasts with 40Ar 39Ar phengite cooling ages from the uderlying schist belt, which are clearly older (by 17-22 m.y.). Fabrics in both the amphibolite-facies rocks and schist belt are characterized by repeated cycles of N-vergent crenulation and transposition that was likely associated with out-of-sequence ductile thrusting in the internal zone of the Brooks Range orogen. Contractional deformation occurred in an overall environment of foreland-directed tectonic transport, broadly synchronous with exhumation of the internal zone, and shortening within the thin-skinned fold and thrust belt. These data are inconsistent with a recently postulated mid-Cretaceous episode of lithospheric extension in northern Alaska. ?? 1994.

Chromosomal characteristics and distribution of rDNA sequences in the brook trout Salvelinus fontinalis (Mitchill, 1814).

PubMed

Śliwińska-Jewsiewicka, A; Kuciński, M; Kirtiklis, L; Dobosz, S; Ocalewicz, K; Jankun, Malgorzata

2015-08-01

Brook trout Salvelinus fontinalis (Mitchill, 1814) chromosomes have been analyzed using conventional and molecular cytogenetic techniques enabling characteristics and chromosomal location of heterochromatin, nucleolus organizer regions (NORs), ribosomal RNA-encoding genes and telomeric DNA sequences. The C-banding and chromosome digestion with the restriction endonucleases demonstrated distribution and heterogeneity of the heterochromatin in the brook trout genome. DNA sequences of the ribosomal RNA genes, namely the nucleolus-forming 28S (major) and non-nucleolus-forming 5S (minor) rDNAs, were physically mapped using fluorescence in situ hybridization (FISH) and primed in situ labelling. The minor rDNA locus was located on the subtelo-acrocentric chromosome pair No. 9, whereas the major rDNA loci were dispersed on 14 chromosome pairs, showing a considerable inter-individual variation in the number and location. The major and minor rDNA loci were located at different chromosomes. Multichromosomal location (3-6 sites) of the NORs was demonstrated by silver nitrate (AgNO3) impregnation. All Ag-positive i.e. active NORs corresponded to the GC-rich blocks of heterochromatin. FISH with telomeric probe showed the presence of the interstitial telomeric site (ITS) adjacent to the NOR/28S rDNA site on the chromosome 11. This ITS was presumably remnant of the chromosome rearrangement(s) leading to the genomic redistribution of the rDNA sequences. Comparative analysis of the cytogenetic data among several related salmonid species confirmed huge variation in the number and the chromosomal location of rRNA gene clusters in the Salvelinus genome.

Soil bacterial communities of a calcium-supplemented and a reference watershed at the Hubbard Brook Experimental Forest (HBEF), New Hampshire, USA

Treesearch

Ganapathi Sridevi; Rakesh Minocha; Swathi A. Turlapati; Katherine C. Goldfarb; Eoin L. Brodie; Louis S. Tisa; Subhash C. Minocha

2012-01-01

Soil Ca depletion because of acidic deposition-related soil chemistry changes has led to the decline of forest productivity and carbon sequestration in the northeastern USA. In 1999, acidic watershed (WS) 1 at the Hubbard Brook Experimental Forest (HBEF), NH, USA was amended with Ca silicate to restore soil Ca pools. In 2006, soil samples were collected from the Ca-...

A review of rate control in atrial fibrillation, and the rationale and protocol for the RATE-AF trial

PubMed Central

Deeks, Jonathan J; Griffith, Michael; Lip, Gregory YH; Mehta, Samir; Slinn, Gemma; Stanbury, Mary; Steeds, Richard P; Townend, Jonathan N

2017-01-01

Background and objective Atrial fibrillation (AF) is common and causes impaired quality of life, an increased risk of stroke and death as well as frequent hospital admissions. The majority of patients with AF require control of heart rate. In this article, we summarise the limited evidence from clinical trials that guides prescription, and present the rationale and protocol for a new randomised trial. As rate control has not yet been shown to reduce mortality, there is a clear need to compare the impact of therapy on quality of life, cardiac function and exercise capacity. Such a trial should concentrate on the long-term effects of treatment in the largest proportion of patients with AF, those with symptomatic permanent AF, with the aim of improving patient well-being. Design and intervention The RAte control Therapy Evaluation in permanent Atrial Fibrillation (RATE-AF) trial will enrol 160 participants with a prospective, randomised, open-label, blinded end point design comparing initial rate control with digoxin or bisoprolol. This will be the first head-to-head randomised trial of digoxin and beta-blockers in AF. Participants Recruited patients will be aged ≥60 years with permanent AF and symptoms of breathlessness (equivalent to New York Heart Association class II or above), with few exclusion criteria to maximise generalisability to routine clinical practice. Outcome measures The primary outcome is patient-reported quality of life, with secondary outcomes including echocardiographic ventricular function, exercise capacity and biomarkers of cellular and clinical response. Follow-up will occur at 6 and 12 months, with feasibility components to inform the design of a future trial powered to detect a difference in hospital admission. The RATE-AF trial will underpin an integrated approach to management including biomarkers, functions and symptoms that will guide future research into optimal, personalised rate control in patients with AF. Ethics and dissemination

Mobile Health Technology for Atrial Fibrillation Management Integrating Decision Support, Education, and Patient Involvement: mAF App Trial.

PubMed

Guo, Yutao; Chen, Yundai; Lane, Deirdre A; Liu, Lihong; Wang, Yutang; Lip, Gregory Y H

2017-12-01

Mobile Health technology for the management of patients with atrial fibrillation is unknown. The simple mobile AF (mAF) App was designed to incorporate clinical decision-support tools (CHA 2 DS 2 -VASc [Congestive heart failure, Hypertension, Age ≥75 years, Diabetes Mellitus, Prior Stroke or TIA, Vascular disease, Age 65-74 years, Sex category], HAS-BLED [Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile INR, Elderly, Drugs/alcohol concomitantly], SAMe-TT 2 R 2 [Sex, Age <60 years, Medical history, Treatment, Tobacco use, Race] scores), educational materials, and patient involvement strategies with self-care protocols and structured follow-up. Patients with atrial fibrillation were randomized into 2 groups (mAF App vs usual care) in a cluster randomized design pilot study. Patients' knowledge, quality of life, drug adherence, and anticoagulation satisfaction were evaluated at baseline, 1 month, and 3 months. Usability, feasibility, and acceptability of the mAF App were assessed at 1 month. A total of 113 patients were randomized to mAF App intervention (mean age, 67.4 years; 57.5% were male; mean follow-up, 69 days), and 96 patients were randomized to usual care (mean age, 70.9 years; 55.2% were male; mean follow-up, 95 days). More than 90% of patients reported that the mAF App was easy, user-friendly, helpful, and associated with significant improvements in knowledge compared with the usual care arm (P values for trend <.05). Drug adherence and anticoagulant satisfaction were significantly better with the mAF App versus usual care (all P < .05). Quality of life scores were significantly increased in the mAF App arm versus usual care, with anxiety and depression reduced (all P < .05). The pilot mAFA Trial is the first prospective randomized trial of Mobile Health technology in patients with atrial fibrillation, demonstrating that the mAF App, integrating clinical decision support, education, and patient

Environmental Assessment for Clear AFS Grid Tie-in and Heat Plant, Clear Air Force Station, Alaska

DTIC Science & Technology

2013-07-01

greenhouse gases are presented in this section. 3.3.2.1 Air Quality Standards All stationary and mobile sources of air pollutants within a...These inventories provide estimates of criteria pollutant emissions associated with industrial sources, residential wood burning, mobile sources...larger, more mobile wildlife species are expected to vacate the project area, whereas individuals of less mobile species (i.e., small mammals,) could

State University of New York, University of Stoney Brook, University and Clinical Practice Management Plan Space Leasing Practices. Report 96-S-36.

ERIC Educational Resources Information Center

New York State Office of the Comptroller, Albany. Div. of Management Audit.

This audit report assesses the propriety and economy of space leasing practices of the State University of New York at Stony Brook (SUNY-SB) for the period July 1, 1994 through December 31, 1996, specifically those related to a health center that includes five professional schools, a 536-bed teaching hospital, and a 350-bed veterans' home. Some of…

Assessing Wetland Hydroperiod and Soil Moisture With Remote Sensing: A Demonstration for the NASA Plum Brook Station Year 2

NASA Technical Reports Server (NTRS)

Brooks, Colin; Bourgeau-Chavez, Laura; Endres, Sarah; Battaglia, Michael; Shuchman, Robert

2015-01-01

Primary Goal: Assist with the evaluation and measuring of wetlands hydroperiod at the PlumBrook Station using multi-source remote sensing data as part of a larger effort on projecting climate change-related impacts on the station's wetland ecosystems. MTRI expanded on the multi-source remote sensing capabilities to help estimate and measure hydroperiod and the relative soil moisture of wetlands at NASA's Plum Brook Station. Multi-source remote sensing capabilities are useful in estimating and measuring hydroperiod and relative soil moisture of wetlands. This is important as a changing regional climate has several potential risks for wetland ecosystem function. The year two analysis built on the first year of the project by acquiring and analyzing remote sensing data for additional dates and types of imagery, combined with focused field work. Five deliverables were planned and completed: 1) Show the relative length of hydroperiod using available remote sensing datasets 2) Date linked table of wetlands extent over time for all feasible non-forested wetlands 3) Utilize LIDAR data to measure topographic height above sea level of all wetlands, wetland to catchment area radio, slope of wetlands, and other useful variables 4) A demonstration of how analyzed results from multiple remote sensing data sources can help with wetlands vulnerability assessment 5) A MTRI style report summarizing year 2 results. This report serves as a descriptive summary of our completion of these our deliverables. Additionally, two formal meetings were held with Larry Liou and Amanda Sprinzl to provide project updates and receive direction on outputs. These were held on 2/26/15 and 9/17/15 at the Plum Brook Station. Principal Component Analysis (PCA) is a multivariate statistical technique used to identify dominant spatial and temporal backscatter signatures. PCA reduces the information contained in the temporal dataset to the first few new Principal Component (PC) images. Some advantages of PCA

Getting Our Partners Airborne: Training Air Advisors and Their Impact In-Theater

DTIC Science & Technology

2014-06-01

perform, over time, their roles and responsi- bilities independent of US assistance. This approach is now mature in Iraq, and if the United States...Afghan airframes has begun to bear fruit . Three AAF classes have completed their pilot training in Afghanistan and, on 23 June 2013, the fourth class...launched the KA-350 program and, after it matured , transitioned operations and maintenance to full control of the IqAF. May–June 2014 Air & Space

Recursive Forecasting System for Person-Job Match.

DTIC Science & Technology

1980-09-01

AFHRL-TR-77-47, AD-A048 983, Brooks AFB, Texas: Occupation and Manpower Research Division, Air Force Human Resources Laboratory, August, 1977. 31. Ward, J...A056 531, Brooks AFB, Texas, Occupation and Manpower Research Division, Air Force Human Resources Laboratory, July, 1978. 32. Whittle, P., Prediction and... AUTOMI IC [1IFF [EI " THE FOL[..JU’ ARE THE ELEMENTS OF THE STAT VECIOR CANON I CAL C11RFFEL V) I N 1 .0000 C[ 1 LJ 9999.99 D . F . 3 TNF. CR1T. 9993.99

Soilaluminum, iron, and phosphorus dynamics in response to long-term experimental nitrogen and sulfur additions at the Bear Brook Watershed in Maine, USA

Treesearch

Jessica Sherman; Ivan J. Fernandez; Stephen A. Norton; Tsutomu Ohno; Lindsey E. Rustad

2006-01-01

Atmospheric deposition of nitrogen (N) and sulfur (S) containing compounds affects soil chemistry in forested ecosystems through (1) acidification and the depletion of base cations, (2) metal mobilization, particularly aluminum (Al), and iron (Fe), (3) phosphorus (P) mobilization, and (4) N accumulation. The Bear BrookWatershed in Maine (BBWM) is a long-term paired...

A Detailed Study of Advection Sea Fog Formation to Reduce the Operational Impacts Along the Northern Gulf of Mexico

DTIC Science & Technology

2007-03-01

From Mid-Air Collision Avoidance Pilot Education Program, Tyndall Air Force Base. http://www.tyndall.af.mil/ MACA /moamap.pdf Accessed 10 September...Collision Avoidance Pilot Education Program, Tyndall Air Force Base. http://www.tyndall.af.mil/ MACA /moamap.pdf Accessed 10 September 2006). 5...cited 2006: Tyndall Air Force Base. [Available online at http://www.tyndall.af.mil/ MACA /moamap.pdf]. Accessed 25 September 2006. Mid-Air Collision

Arsenic Removal from Drinking Water by Adsorptive Media U.S. EPA Demonstration Project at Spring Brook Mobile Home Park in Wales, ME Final Performance Evaluation Report

EPA Science Inventory

This report documents the activities performed and the results obtained for the arsenic removal treatment technology demonstration project at Spring Brook Mobile Home Park (SBMHP) in Wales, Maine. The objectives of the project were to evaluate: 1) the effectiveness of an arsenic...

Validation of the Framingham Heart Study and CHARGE-AF Risk Scores for Atrial Fibrillation in Hispanics, African-Americans, and Non-Hispanic Whites.

PubMed

Shulman, Eric; Kargoli, Faraj; Aagaard, Philip; Hoch, Ethan; Di Biase, Luigi; Fisher, John; Gross, Jay; Kim, Soo; Krumerman, Andrew; Ferrick, Kevin J

2016-01-01

A risk score for atrial fibrillation (AF) has been developed by the Framingham Heart Study and Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)-AF consortium. However, validation of these risk scores in an inner-city population is uncertain. Thus, a validation model was built using the Framingham Risk Score for AF and CHARGE-AF covariates. An in and outpatient electrocardiographic database was interrogated from 2000 to 2013 for the development of AF. Patients were included if their age was >45 and <95 years, had <10-year follow-up, if their initial electrocardiogram was without AF, had ≥ 2 electrocardiograms, and declared a race and/or ethnicity as non-Hispanic white, African-American, or Hispanic. For the Framingham Heart Study, 49,599 patients met inclusion criteria, of which 4,860 developed AF. Discrimination analysis using area under the curve (AUC) for original risk equations: non-Hispanic white AUC = 0.712 (95% confidence interval [CI] 0.694 to 0.731), African-American AUC = 0.733 (95% CI 0.716 to 0.751), and Hispanic AUC = 0.740 (95% CI 0.723 to 0.757). For the CHARGE-AF, 45,571 patients met inclusion criteria, of which 4,512 developed AF. Non-Hispanic white AUC = 0.673 (95% CI 0.652 to 0.694), African-American AUC = 0.706 (95% CI 0.685 to 0.727), and Hispanic AUC = 0.711 (95% CI 0.691 to 0.732). Calibration analysis showed qualitative similarities between cohorts. In conclusion, this is the first study to validate both the Framingham Heart Study and CHARGE-AF risk scores in both a Hispanic and African-American cohort. All models predicted AF well across all race and ethnic cohorts. Copyright © 2016 Elsevier Inc. All rights reserved.

Stability of rotors and focal sources for human atrial fibrillation: focal impulse and rotor mapping (FIRM) of AF sources and fibrillatory conduction.

PubMed

Swarup, Vijay; Baykaner, Tina; Rostamian, Armand; Daubert, James P; Hummel, John; Krummen, David E; Trikha, Rishi; Miller, John M; Tomassoni, Gery F; Narayan, Sanjiv M

2014-12-01

Several groups report electrical rotors or focal sources that sustain atrial fibrillation (AF) after it has been triggered. However, it is difficult to separate stable from unstable activity in prior studies that examined only seconds of AF. We applied phase-based focal impulse and rotor mapping (FIRM) to study the dynamics of rotors/sources in human AF over prolonged periods of time. We prospectively mapped AF in 260 patients (169 persistent, 61 ± 12 years) at 6 centers in the FIRM registry, using baskets with 64 contact electrodes per atrium. AF was phase mapped (RhythmView, Topera, Menlo Park, CA, USA). AF propagation movies were interpreted by each operator to assess the source stability/dynamics over tens of minutes before ablation. Sources were identified in 258 of 260 of patients (99%), for 2.8 ± 1.4 sources/patient (1.8 ± 1.1 in left, 1.1 ± 0.8 in right atria). While AF sources precessed in stable regions, emanating activity including spiral waves varied from collision/fusion (fibrillatory conduction). Each source lay in stable atrial regions for 4,196 ± 6,360 cycles, with no differences between paroxysmal versus persistent AF (4,290 ± 5,847 vs. 4,150 ± 6,604; P = 0.78), or right versus left atrial sources (P = 0.26). Rotors and focal sources for human AF mapped by FIRM over prolonged time periods precess ("wobble") but remain within stable regions for thousands of cycles. Conversely, emanating activity such as spiral waves disorganize and collide with the fibrillatory milieu, explaining difficulties in using activation mapping or signal processing analyses at fixed electrodes to detect AF rotors. These results provide a rationale for targeted ablation at AF sources rather than fibrillatory spiral waves. © 2014 Wiley Periodicals, Inc.

Decompression Sickness After Air Break in Prebreathe Described with a Survival Model

NASA Technical Reports Server (NTRS)

Conkin, J.; Pilmanis, A. A.

2010-01-01

Data from Brooks City-Base show the decompression sickness (DCS) and venous gas emboli (VGE) consequences of air breaks in a resting 100% O2 prebreathe (PB) prior to a hypobaric exposure. METHODS: DCS and VGE survival times from 95 controls for a 60 min PB prior to 2-hr or 4-hr exposures to 4.37 psia are statistically compared to 3 break in PB conditions: a 10 min (n=40), 20 min (n=40), or 60 min break (n=32) 30 min into the PB followed by 30 min of PB. Ascent rate was 1,524 meters / min and all exposures included light exercise and 4 min of VGE monitoring of heart chambers at 16 min intervals. DCS survival time for combined control and air breaks were described with an accelerated log logistic model where exponential N2 washin during air break was described with a 10 min half-time and washout during PB with a 60 min half-time. RESULTS: There was no difference in VGE or DCS survival times among 3 different air breaks, or when air breaks were compared to control VGE times. However, 10, 20, and 60 min air breaks had significantly earlier survival times compared to control DCS times, certainly early in the exposures. CONCLUSION: Air breaks of 10, 20, and 60 min after 30 min of a 60 min PB reduced DCS survival time. The survival model combined discrete comparisons into a global description mechanistically linked to asymmetrical N2 washin and washout kinetics based on inspired pN2. Our unvalidated regression is used to compute additional PB time needed to compensate for an air break in PB within the range of tested conditions.

Assessing Wetland Hydroperiod and Soil Moisture with Remote Sensing: A Demonstration for the NASA Plum Brook Station Year 2

NASA Technical Reports Server (NTRS)

Brooks, Colin; Bourgeau-Chavez, Laura; Endres, Sarah; Battaglia, Michael; Shuchman, Robert

2015-01-01

Assist with the evaluation and measuring of wetlands hydroperiod at the Plum Brook Station using multi-source remote sensing data as part of a larger effort on projecting climate change-related impacts on the station's wetland ecosystems. MTRI expanded on the multi-source remote sensing capabilities to help estimate and measure hydroperiod and the relative soil moisture of wetlands at NASA's Plum Brook Station. Multi-source remote sensing capabilities are useful in estimating and measuring hydroperiod and relative soil moisture of wetlands. This is important as a changing regional climate has several potential risks for wetland ecosystem function. The year two analysis built on the first year of the project by acquiring and analyzing remote sensing data for additional dates and types of imagery, combined with focused field work. Five deliverables were planned and completed: (1) Show the relative length of hydroperiod using available remote sensing datasets, (2) Date linked table of wetlands extent over time for all feasible non-forested wetlands, (3) Utilize LIDAR data to measure topographic height above sea level of all wetlands, wetland to catchment area radio, slope of wetlands, and other useful variables (4), A demonstration of how analyzed results from multiple remote sensing data sources can help with wetlands vulnerability assessment; and (5) A MTRI style report summarizing year 2 results.

Implanting 8-mm passive integrated transponder tags into small Brook Trout: Effects on growth and survival in the laboratory

USGS Publications Warehouse

O'Donnell, Matthew J.; Letcher, Benjamin H.

2017-01-01

Passive integrated transponder (PIT) tags are commonly used to investigate relationships between individual fish and their environment. The recent availability of smaller tags has provided the opportunity to tag smaller fish. In this study, we implanted 8-mm PIT tags into small Brook Trout Salvelinus fontinalis (35–50 mm FL; 0.35–1.266 g) and compared tag retention, growth rates, and survival of PIT-tagged fish with those of fish subjected to handling only or to handling plus fin clipping. We also examined how initial size at tagging affected absolute and specific growth rates of PIT-tagged individuals over time. We found that survival was 100%, tag retention was 96.7%, and fish size did not vary across treatments at 29 and 64 d posttagging. Additionally, there was no evidence that growth rate (FL or mass) was influenced by the initial size of the fish that were PIT tagged. Our results indicate that retention rates of 8-mm PIT tags surgically implanted into small Brook Trout are high and that there is no discernible effect on growth or survival in the laboratory. The ability to implant smaller PIT tags into smaller fish earlier in the season would allow researchers conducting PIT tag studies to expand demographic models to estimate survival of age-0 fish through the summer of their first year.

A review of rate control in atrial fibrillation, and the rationale and protocol for the RATE-AF trial.

PubMed

Kotecha, Dipak; Calvert, Melanie; Deeks, Jonathan J; Griffith, Michael; Kirchhof, Paulus; Lip, Gregory Yh; Mehta, Samir; Slinn, Gemma; Stanbury, Mary; Steeds, Richard P; Townend, Jonathan N

2017-07-20

Atrial fibrillation (AF) is common and causes impaired quality of life, an increased risk of stroke and death as well as frequent hospital admissions. The majority of patients with AF require control of heart rate. In this article , we summarise the limited evidence from clinical trials that guides prescription, and present the rationale and protocol for a new randomised trial. As rate control has not yet been shown to reduce mortality, there is a clear need to compare the impact of therapy on quality of life, cardiac function and exercise capacity. Such a trial should concentrate on the long-term effects of treatment in the largest proportion of patients with AF, those with symptomatic permanent AF, with the aim of improving patient well-being. The RAte control Therapy Evaluation in permanent Atrial Fibrillation (RATE-AF) trial will enrol 160 participants with a prospective, randomised, open-label, blinded end point design comparing initial rate control with digoxin or bisoprolol. This will be the first head-to-head randomised trial of digoxin and beta-blockers in AF. Recruited patients will be aged ≥60 years with permanent AF and symptoms of breathlessness (equivalent to New York Heart Association class II or above), with few exclusion criteria to maximise generalisability to routine clinical practice. The primary outcome is patient-reported quality of life, with secondary outcomes including echocardiographic ventricular function, exercise capacity and biomarkers of cellular and clinical response. Follow-up will occur at 6 and 12 months, with feasibility components to inform the design of a future trial powered to detect a difference in hospital admission. The RATE-AF trial will underpin an integrated approach to management including biomarkers, functions and symptoms that will guide future research into optimal, personalised rate control in patients with AF. East Midlands-Derby Research Ethics Committee (16/EM/0178); peer-reviewed publications

Mycobactericidal and tuberculocidal activity of Korsolex AF, an amine detergent/disinfectant product.

PubMed

Hernández, A; Martró, E; Matas, L; Jiménez, A; Ausina, V

2005-01-01

The mycobactericidal and tuberculocidal activities of Korsolex AF against Mycobacterium tuberculosis, Mycobacterium avium-Mycobacterium intracellulare (MAI), Mycobacterium kansasii and Mycobacterium chelonae were determined using quantitative suspension and carrier tests. The effects of organic load and hard water were also considered. A clinical isolate of MAI was the most resistant of the four test organisms. A 2% solution had good mycobactericidal and tuberculocidal activities after 30 min of exposure. Although further evaluation using European standard tests is necessary, we conclude that Korsolex AF appears to be a promising product for the disinfection of hospital instruments contaminated with mycobacteria.

Feasibility and cost-effectiveness of stroke prevention through community screening for atrial fibrillation using iPhone ECG in pharmacies. The SEARCH-AF study.

PubMed

Lowres, Nicole; Neubeck, Lis; Salkeld, Glenn; Krass, Ines; McLachlan, Andrew J; Redfern, Julie; Bennett, Alexandra A; Briffa, Tom; Bauman, Adrian; Martinez, Carlos; Wallenhorst, Christopher; Lau, Jerrett K; Brieger, David B; Sy, Raymond W; Freedman, S Ben

2014-06-01

Atrial fibrillation (AF) causes a third of all strokes, but often goes undetected before stroke. Identification of unknown AF in the community and subsequent anti-thrombotic treatment could reduce stroke burden. We investigated community screening for unknown AF using an iPhone electrocardiogram (iECG) in pharmacies, and determined the cost-effectiveness of this strategy.Pharmacists performedpulse palpation and iECG recordings, with cardiologist iECG over-reading. General practitioner review/12-lead ECG was facilitated for suspected new AF. An automated AF algorithm was retrospectively applied to collected iECGs. Cost-effectiveness analysis incorporated costs of iECG screening, and treatment/outcome data from a United Kingdom cohort of 5,555 patients with incidentally detected asymptomatic AF. A total of 1,000 pharmacy customers aged ≥65 years (mean 76 ± 7 years; 44% male) were screened. Newly identified AF was found in 1.5% (95% CI, 0.8-2.5%); mean age 79 ± 6 years; all had CHA2DS2-VASc score ≥2. AF prevalence was 6.7% (67/1,000). The automated iECG algorithm showed 98.5% (CI, 92-100%) sensitivity for AF detection and 91.4% (CI, 89-93%) specificity. The incremental cost-effectiveness ratio of extending iECG screening into the community, based on 55% warfarin prescription adherence, would be $AUD5,988 (€3,142; $USD4,066) per Quality Adjusted Life Year gained and $AUD30,481 (€15,993; $USD20,695) for preventing one stroke. Sensitivity analysis indicated cost-effectiveness improved with increased treatment adherence.Screening with iECG in pharmacies with an automated algorithm is both feasible and cost-effective. The high and largely preventable stroke/thromboembolism risk of those with newly identified AF highlights the likely benefits of community AF screening. Guideline recommendation of community iECG AF screening should be considered.

Long-term calcium addition increases growth release, wound closure, and health of sugar maple (Acer saccharum) trees at the Hubbard Brook Experimental Forest

Treesearch

Brett A. Huggett; Paul G. Schaberg; Gary J. Hawley; Christopher Eager

2007-01-01

We surveyed and wounded forest-grown sugar maple (Acer saccharum Marsh.) trees in a long-term, replicated Ca manipulation study at the Hubbard Brook Experimental Forest in New Hampshire, USA. Plots received applications of Ca (to boost Ca availability above depleted ambient levels) or A1 (to compete with Ca uptake and further reduce Ca availability...

Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice.

PubMed

Caudell, David; Harper, David P; Novak, Rachel L; Pierce, Rachel M; Slape, Christopher; Wolff, Linda; Aplan, Peter D

2010-02-11

The t(10;11) translocation results in a CALM-AF10 fusion gene in a subset of leukemia patients. Expression of a CALM-AF10 transgene results in leukemia, with prolonged latency and incomplete penetrance, suggesting that additional events are necessary for leukemic transformation. CALM-AF10 mice infected with the MOL4070LTR retrovirus developed acute leukemia, and ligation-mediated polymerase chain reaction was used to identify retroviral insertions at 19 common insertion sites, including Zeb2, Nf1, Mn1, Evi1, Ift57, Mpl, Plag1, Kras, Erg, Vav1, and Gata1. A total of 26% (11 of 42) of the mice had retroviral integrations near Zeb2, a transcriptional corepressor leading to overexpression of the Zeb2-transcript. A total of 91% (10 of 11) of mice with Zeb2 insertions developed B-lineage acute lymphoblastic leukemia, suggesting that Zeb2 activation promotes the transformation of CALM-AF10 hematopoietic precursors toward B-lineage leukemias. More than half of the mice with Zeb2 integrations also had Nf1 integrations, suggesting cooperativity among CALM-AF10, Zeb2, and Ras pathway mutations. We searched for Nras, Kras, and Ptpn11 point mutations in the CALM-AF10 leukemic mice. Three mutations were identified, all of which occurred in mice with Zeb2 integrations, consistent with the hypothesis that Zeb2 and Ras pathway activation promotes B-lineage leukemic transformation in concert with CALM-AF10.

Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice

PubMed Central

Caudell, David; Harper, David P.; Novak, Rachel L.; Pierce, Rachel M.; Slape, Christopher; Wolff, Linda

2010-01-01

The t(10;11) translocation results in a CALM-AF10 fusion gene in a subset of leukemia patients. Expression of a CALM-AF10 transgene results in leukemia, with prolonged latency and incomplete penetrance, suggesting that additional events are necessary for leukemic transformation. CALM-AF10 mice infected with the MOL4070LTR retrovirus developed acute leukemia, and ligation-mediated polymerase chain reaction was used to identify retroviral insertions at 19 common insertion sites, including Zeb2, Nf1, Mn1, Evi1, Ift57, Mpl, Plag1, Kras, Erg, Vav1, and Gata1. A total of 26% (11 of 42) of the mice had retroviral integrations near Zeb2, a transcriptional corepressor leading to overexpression of the Zeb2-transcript. A total of 91% (10 of 11) of mice with Zeb2 insertions developed B-lineage acute lymphoblastic leukemia, suggesting that Zeb2 activation promotes the transformation of CALM-AF10 hematopoietic precursors toward B-lineage leukemias. More than half of the mice with Zeb2 integrations also had Nf1 integrations, suggesting cooperativity among CALM-AF10, Zeb2, and Ras pathway mutations. We searched for Nras, Kras, and Ptpn11 point mutations in the CALM-AF10 leukemic mice. Three mutations were identified, all of which occurred in mice with Zeb2 integrations, consistent with the hypothesis that Zeb2 and Ras pathway activation promotes B-lineage leukemic transformation in concert with CALM-AF10. PMID:20007546

The Role of U2AF1 Mutations in the Pathogenesis of Myelodysplastic Syndromes

DTIC Science & Technology

2016-12-01

U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 DISTRIBUTION STATEMENT: Approved for public release...ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 11. SPONSOR/MONITOR’S...induction, U2AF1(S34F) mice have reduced WBCs, increased hematopoietic stem /progenitor cells, and increased HSC cell cycling compared to U2AF1(WT) mice

The United States Air Force and the Culture of Innovation, 1945-1965

DTIC Science & Technology

2002-01-01

US Dept of Transportation; typically they hover between 85 and 95 percent. 16. Kent C. Redmond and Thomas M. Smith, Project Whirlwind: A Case Histo...Washing- ton, D.C.: AF Hist and Museums Prog, 1994). 14. Thomas A . Sturm, The USAF SAB: Its First Twenty Years 1944–1964 (Washington, D.C.: USAF...allegations at Ramo-Wooldridge and the Air Force’s approach. Schriever answered them in a letter to Lt. Gen. Thomas Power, the commander of ARDC, in

Addressing information gaps in wild-caught foods in the US: Brook trout nutritional analysis for inclusion into the USDA national nutrient database for standard reference

USDA-ARS?s Scientific Manuscript database

Many species of wild game and fish that are legal to hunt or catch do not have nutrition information in the USDA National Nutrient Database for Standard Reference (SR). Among those species that lack nutrition information are brook trout. The research team worked with the Nutrient Data Laboratory wit...

ARSENIC REMOVAL FROM DRINKING WATER BY ADSORPTIVE MEDIA U.S. EPA DEMONSTRATION PROJECT AT SPRING BROOK MOBILE HOME PARK IN WALES, ME SIX-MONTH EVALUATION REPORT

EPA Science Inventory

This report documents the activities performed during and the results obtained from the first six months of the arsenic removal treatment technology demonstration project at the Spring Brook Mobile Home Park in Wales, ME. The objectives of the project are to evaluate the effectiv...

Proposed Facility Modifications to Support Propulsion Systems Testing Under Simulated Space Conditions at Plum Brook Station's Spacecraft Propulsion Research Facility (B-2)

NASA Technical Reports Server (NTRS)

Edwards, Daryl A.

2008-01-01

Preparing NASA's Plum Brook Station's Spacecraft Propulsion Research Facility (B-2) to support NASA's new generation of launch vehicles has raised many challenges for B-2's support staff. The facility provides a unique capability to test chemical propulsion systems/vehicles while simulating space thermal and vacuum environments. Designed and constructed in the early 1960s to support upper stage cryogenic engine/vehicle system development, the Plum Brook Station B-2 facility will require modifications to support the larger, more powerful, and more advanced engine systems for the next generation of vehicles leaving earth's orbit. Engine design improvements over the years have included large area expansion ratio nozzles, greater combustion chamber pressures, and advanced materials. Consequently, it has become necessary to determine what facility changes are required and how the facility can be adapted to support varying customers and their specific test needs. Exhaust system performance, including understanding the present facility capabilities, is the primary focus of this work. A variety of approaches and analytical tools are being employed to gain this understanding. This presentation discusses some of the challenges in applying these tools to this project and expected facility configuration to support the varying customer needs.

Proposed Facility Modifications to Support Propulsion Systems Testing Under Simulated Space Conditions at Plum Brook Station's Spacecraft Propulsion Research Facility (B-2)

NASA Technical Reports Server (NTRS)

Edwards, Daryl A.

2007-01-01

Preparing NASA's Plum Brook Station's Spacecraft Propulsion Research Facility (B-2) to support NASA's new generation of launch vehicles has raised many challenges for B-2 s support staff. The facility provides a unique capability to test chemical propulsion systems/vehicles while simulating space thermal and vacuum environments. Designed and constructed 4 decades ago to support upper stage cryogenic engine/vehicle system development, the Plum Brook Station B-2 facility will require modifications to support the larger, more powerful, and more advanced engine systems for the next generation of vehicles leaving earth's orbit. Engine design improvements over the years have included large area expansion ratio nozzles, greater combustion chamber pressures, and advanced materials. Consequently, it has become necessary to determine what facility changes are required and how the facility can be adapted to support varying customers and their specific test needs. Instrumental in this task is understanding the present facility capabilities and identifying what reasonable changes can be implemented. A variety of approaches and analytical tools are being employed to gain this understanding. This paper discusses some of the challenges in applying these tools to this project and expected facility configuration to support the varying customer needs.

Fabrication of (U, Zr) C-fueled/tungsten-clad specimens for irradiation in the Plum Brook Reactor Facility

NASA Technical Reports Server (NTRS)

1972-01-01

Fuel samples, 90UC - 10 ZrC, and chemically vapor deposited tungsten fuel cups were fabricated for the study of the long term dimensional stability and compatibility of the carbide-tungsten fuel-cladding systems under irradiation. These fuel samples and fuel cups were assembled into the fuel pins of two capsules, designated as V-2E and V-2F, for irradiation in NASA Plum Brook Reactor Facility at a fission power density of 172 watts/c.c. and a miximum cladding temperature of 1823 K. Fabrication methods and characteristics of the fuel samples and fuel cups prepared are described.

Characterization of esculin-positive Pseudomonas fluorescens strains isolated from an underground brook.

PubMed

Svec, P; Stegnerová, H; Durnová, E; Sedlácek, I

2004-01-01

A group of sixteen esculin-positive fluorescent pseudomonads isolated from an underground brook flowing through a cave complex was characterized by biotyping, multiple enzyme restriction fragment length polymorphism analysis of 16S rDNA (MERFLP), ribotyping and whole-cell fatty-acid methyl-esters analysis (FAME). All strains were phenotypically close to Pseudomonas fluorescens, but they revealed high biochemical variability as well as some reactions atypical for P. fluorescens species. Because identification of pseudomonads by of biochemical testing is often unclear, further techniques were employed. Fingerprints obtained by MERFLP clearly showed that all strains represent P. fluorescens species. Ribotyping separated the strains analyzed into four groups corresponding almost completely (with the exception of one strain) to the clustering based on biochemical profiles. FAME analysis grouped all the strains into one cluster together with the P. putida (biotype A, B), P. chlororaphis and P. fluorescens biotype F representatives, but differentiated them from other FAME profiles of all pseudomonads included in the standard library TSBA 40 provided by MIDI, Inc.

Provenance and detrital zircon geochronologic evolution of lower Brookian foreland basin deposits of the western Brooks Range, Alaska, and implications for early Brookian tectonism

USGS Publications Warehouse

Moore, Thomas; O'Sullivan, Paul B.; Potter, Christopher J.; Donelick, Raymond A.

2015-01-01

The Upper Jurassic and Lower Cretaceous part of the Brookian sequence of northern Alaska consists of syntectonic deposits shed from the north-directed, early Brookian orogenic belt. We employ sandstone petrography, detrital zircon U-Pb age analysis, and zircon fission-track double-dating methods to investigate these deposits in a succession of thin regional thrust sheets in the western Brooks Range and in the adjacent Colville foreland basin to determine sediment provenance, sedimentary dispersal patterns, and to reconstruct the evolution of the Brookian orogen. The oldest and structurally highest deposits are allochthonous Upper Jurassic volcanic arc–derived sandstones that rest on accreted ophiolitic and/or subduction assemblage mafic igneous rocks. These strata contain a nearly unimodal Late Jurassic zircon population and are interpreted to be a fragment of a forearc basin that was emplaced onto the Brooks Range during arc-continent collision. Synorogenic deposits found at structurally lower levels contain decreasing amounts of ophiolite and arc debris, Jurassic zircons, and increasing amounts of continentally derived sedimentary detritus accompanied by broadly distributed late Paleozoic and Triassic (359–200 Ma), early Paleozoic (542–359 Ma), and Paleoproterozoic (2000–1750 Ma) zircon populations. The zircon populations display fission-track evidence of cooling during the Brookian event and evidence of an earlier episode of cooling in the late Paleozoic and Triassic. Surprisingly, there is little evidence for erosion of the continental basement of Arctic Alaska, its Paleozoic sedimentary cover, or its hinterland metamorphic rocks in early foreland basin strata at any structural and/or stratigraphic level in the western Brooks Range. Detritus from exhumation of these sources did not arrive in the foreland basin until the middle or late Albian in the central part of the Colville Basin.These observations indicate that two primary provenance areas provided

Draft Genome Sequence of Komagataeibacter intermedius Strain AF2, a Producer of Cellulose, Isolated from Kombucha Tea

PubMed Central

dos Santos, Renato Augusto Corrêa; Berretta, Andresa Aparecida; Barud, Hernane da Silva; Ribeiro, Sidney José Lima; González-García, Laura Natalia; Zucchi, Tiago Domingues

2015-01-01

Here, we present the draft genome sequence of Komagataeibacter intermedius strain AF2, which was isolated from Kombucha tea and is capable of producing cellulose, although at lower levels compared to another bacterium from the same environment, K. rhaeticus strain AF1. PMID:26634755

Deep-water lithofacies and conodont faunas of the Lisburne Group, western Brooks Range, Alaska: A section in Geologic studies in Alaska by the U.S. Geological Survey, 1992

USGS Publications Warehouse

Dumoulin, Julie A.; Harris, Anita G.; Schmidt, Jeanine M.

1993-01-01

Deep-water lithofacies of the Lisburne Group occur in thrust sheets in the western part of the foreland fold and thrust belt of the Brooks Range and represent at least three discrete units. The Kuna Formation (Brooks Range allochthon) consists mostly of spiculitic mudstone and lesser shale; subordinate carbonate layers are chiefly diagenetic dolomite. Predominantly shale sections of the Kuna that contain few sponge spicules occur in the western part of the study area. The Akmalik Chert (Picnic Creek allochthon) is mostly radiolarian-spiculitic chert; rare limy beds are calcitized radiolarite. The Rim Butte unit (Ipnavik River allochthon) consists chiefly of calcareous turbidites, derived from both shallow- and deep-water sources, interbedded with spiculitic mudstone. Much of the material in the turbidites came from a contemporaneous carbonate platform and margin, but some fossils and lithic clasts were eroded from older, already lithified carbonate-platform rocks. All three units appear to be roughly coeval and are chiefly Osagean (late Early Mississippian) in age in the study area.Shallow-water lithofacies of the Lisburne Group exposed in the Howard Pass area (Brooks Range allochthon) are mostly of Meramecian (early Late Mississippian) age. Thus, these carbonate-platform rocks were not the source of the calcareous turbidites in the Rim Butte unit. Rim Butte turbidites could have been derived from older platform carbonate rocks such as those of the Utukok Formation (Kelly River allochthon) exposed mainly to the west of the Howard Pass quadrangle.

Histone acetyltransferase activity of MOF is required for MLL-AF9 leukemogenesis

PubMed Central

Valerio, Daria G.; Xu, Haiming; Chen, Chun-Wei; Hoshii, Takayuki; Eisold, Meghan E.; Delaney, Christopher; Cusan, Monica; Deshpande, Aniruddha J.; Huang, Chun-Hao; Lujambio, Amaia; Zheng, George; Zuber, Johannes; Pandita, Tej K.; Lowe, Scott W.; Armstrong, Scott A.

2017-01-01

Chromatin-based mechanisms offer therapeutic targets in acute myeloid leukemia (AML) that are of great current interest. In this study, we conducted an RNAi-based screen to identify druggable chromatin regulator-based targets in leukemias marked by oncogenic rearrangements of the MLL gene. In this manner, we discovered the H4K16 histone acetyltransferase (HAT) MOF to be important for leukemia cell growth. Conditional deletion of Mof in a mouse model of MLL-AF9-driven leukemogenesis reduced tumor burden and prolonged host survival. RNA sequencing showed an expected downregulation of genes within DNA damage repair pathways that are controlled by MOF, as correlated with a significant increase in yH2AX nuclear foci in Mof-deficient MLL-AF9 tumor cells. In parallel, Mof loss also impaired global H4K16 acetylation in the tumor cell genome. Rescue experiments with catalytically inactive mutants of MOF showed that its enzymatic activity was required to maintain cancer pathogenicity. In support of the role of MOF in sustaining H4K16 acetylation, a small molecule inhibitor of the HAT component MYST blocked the growth of both murine and human MLL-AF9 leukemia cell lines. Furthermore Mof inactivation suppressed leukemia development in a NUP98-HOXA9 driven AML model. Taken together, our results establish that the HAT activity of MOF is required to sustain MLL-AF9 leukemia and may be important for multiple AML subtypes. Blocking this activity is sufficient to stimulate DNA damage, offering a rationale to pursue MOF inhibitors as a targeted approach to treat MLL-rearranged leukemias. PMID:28202522

Characterization of extractable soil organic matter pools from African Dark Earths (AfDE): A case study in historical biochar and organic waste amendments

NASA Astrophysics Data System (ADS)

Fujiu, Manna; Plante, Alain; Ohno, Tsutomu; Solomon, Dawit; Lehmann, Johannes; Fraser, James; Leach, Melissa; Fairhead, James

2014-05-01

Anthropogenic Dark Earths are soils generated through long-term human inputs of organic and pyrogenic materials. These soils were originally discovered in the Amazon, and have since been found in Australia and in this case in Africa. African Dark Earths (AfDE) are black, highly fertile and carbon-rich soils that were formed from the original highly-weathered infertile yellowish to red Oxisols and Ultisols through an extant but hitherto overlooked climate-smart sustainable soil management system that has long been an important feature of the indigenous West African agricultural repertoire. Studies have demonstrated that ADE soils in general have significantly different organic matter properties compared to adjacent non-DE soils, largely attributable to the presence of high concentrations of ash-derived carbon. Quantification and characterization of bulk soil organic matter of several (n=11) AfDE and non-AfDE pairs of surface (0-15 cm) soils using thermal analysis techniques (TG-DSC-EGA) confirmed substantial differences in SOM composition and the presence of pyrogenic C. Such pyrogenic organic matter is generally considered recalcitrant or relatively stable, but the goal of the current study was to characterize the presumably labile, more rapidly cycling, pools of C in AfDEs through the characterization of hot water- and pyrophosphate-extractable fractions, referred to as HWEOC and PyroC respectively. Extracts were analyzed for carbon content, as well as composition using fluorescence (EEM/PARAFAC) and high resolution mass spectrometry (FTICR-MS). The amount of extractable C as a proportion of total soil C was relatively low: less than ~0.8% for HWEOC and 2.8% for PyroC. The proportion of HWEOC did not differ (P = 0.18, paired t-test) between the AfDE and the non-AfDE soils, while the proportions of PyroC were significantly larger (P = 0.001) in the AfDE soils compared to the non-AfDE soils. Preliminary analysis of the EEM/PARAFAC data suggests that AfDE samples had

Alien invasions in aquatic ecosystems: toward an understanding of brook trout invasions and potential impacts on inland cutthroat trout in western North America

Treesearch

Jason B. Dunham; Susan B. Adams; Robert E. Schroeter; Douglas C. Novinger

2002-01-01

Experience from case studies of biological invasions in aquatic ecosystems has motivated a set of proposed empirical “rules” for understanding patterns of invasion and impacts on native species. Further evidence is needed to better understand these patterns, and perhaps contribute to a useful predictive theory of invasions. We reviewed the case of brook trout (

Fracture Mechanics Testing of Titanium 6AL-4V in AF-M315E

NASA Technical Reports Server (NTRS)

Sampson, J. W.; Martinez, J.; McLean, C.

2016-01-01

The Green Propellant Infusion Mission (GPIM) will demonstrate the performance of AF-M315E monopropellant on orbit. Flight certification requires a safe-life analysis of the titanium alloy fuel tank to ensure inherent processing flaws will not cause failure during the design life of the tank. Material property inputs for this analysis require testing to determine the stress intensity factor for environment-assisted cracking (KEAC) of Ti 6Al-4V in combination with the AF-M315E monopropellant. Testing of single-edge notched, or SE(B), specimens representing the bulk tank membrane and weld material were performed in accordance with ASTM E1681. Specimens with fatigue pre-cracks were loaded into test fixtures so that the crack tips were exposed to AF-M315E at 50 C for a duration of 1,000 hours. Specimens that did not fail during exposure were opened to inspect the crack surfaces for evidence of crack growth. The threshold stress intensity value, KEAC, is the highest applied stress intensity that produced neither a failure of the specimen during the exposure nor showed evidence of crack growth. The threshold stress intensity factor for environment-assisted cracking of the Ti 6Al-4V forged tank material was found to be at least 22 ksivin and at least 31 ksivin for the weld material when exposed to AF-M315E monopropellant.

CD82 suppresses CD44 alternative splicing-dependent melanoma metastasis by mediating U2AF2 ubiquitination and degradation

PubMed Central

Fu, Ailing; Zhu, Huifeng; Ren, Qiao; Wang, Bochu; Xu, Xingran; Bai, Huiyuan; Dong, Cheng

2016-01-01

Melanoma is one of the most lethal forms of skin cancer due to its early metastatic spread. The variant form of CD44 (CD44v), a cell surface glycoprotein, is highly expressed on metastatic melanoma. The mechanisms of regulation of CD44 alternative splicing in melanoma and its pathogenic contributions are so far poorly understood. Here, we investigated the expression level of CD44 in a large set of melanocytic lesions at different stages. We found that the expression of CD44v8-10 and a splicing factor, U2AF2, is significantly increased during melanoma progression, while CD82/KAI1, a tetraspanin family of tumor suppressor, is reduced in metastatic melanoma. CD44v8-10 and U2AF2 expressions which are negatively correlated with CD82 levels are dramatically elevated in primary melanoma compared with dysplastic nevi and further increased in metastatic melanoma. We also showed that patients with higher CD44v8-10 and U2AF2 expression levels tended to have shorter survival. By using both in vivo and in vitro assays, we demonstrated that CD82 inhibits the production of CD44v8-10 on melanoma. Mechanistically, U2AF2 is a downstream target of CD82 and in malignant melanoma facilitates CD44v8-10 alternative splicing. U2AF2-mediated CD44 isoform switch is required for melanoma migration in vitro and lung and liver metastasis in vivo. Notably, overexpression of CD82 suppresses U2AF2 activity by inducing U2AF2 ubiquitination. In addition, our data suggested that enhancement of melanoma migration by U2AF2-dependent CD44v8-10 splicing is mediated by Src/FAK/RhoA activation and formation of stress fibers as well as CD44-E-selectin binding reinforcement. These findings uncovered a hitherto unappreciated function of CD82 in severing the linkage between U2AF2-mediated CD44 alternative splicing and cancer aggressiveness, with potential prognostic and therapeutic implications in melanoma. PMID:27041584

Operators in the Plum Brook Reactor Facility Control Room

NASA Image and Video Library

1970-03-21

Donald Rhodes, left, and Clyde Greer, right, monitor the operation of the National Aeronautics and Space Administration’s (NASA) Plum Brook Reactor Facility from the control room. The 60-megawatt test reactor, NASA’s only reactor, was the eighth largest test reactor in the world. The facility was built by the Lewis Research Center in the late 1950s to study the effects of radiation on different materials that could be used to construct nuclear propulsion systems for aircraft or rockets. The reactor went critical for the first time in 1961. For the next two years, two operators were on duty 24 hours per day working on the fission process until the reactor reached its full-power level in 1963. Reactor Operators were responsible for monitoring and controlling the reactor systems. Once the reactor was running under normal operating conditions, the work was relatively uneventful. Normally the reactor was kept at a designated power level within certain limits. Occasionally the operators had to increase the power for a certain test. The shift supervisor and several different people would get together and discuss the change before boosting the power. All operators were required to maintain a Reactor Operator License from the Atomic Energy Commission. The license included six months of training, an eight-hour written exam, a four-hour walkaround, and testing on the reactor controls.

Titration of Serum Lipoproteins with Lipoprotein Precipitants.

DTIC Science & Technology

1981-12-01

Lipid Res 11:583 (1970). 6. Grove, T. H. Effect of reagent pH on determination of high-density lipo- protein cholesterol by precipitation with sodium ...of choles- terol in the supernate plateaued at 43 mg/dl after the beta and prebeta lipo- proteins had been precipitated . The intensities of the two...AD-A113 370 SCHOOL OF AEROSPACE MEDICINE BROOKS AFS TX F/S 6/1 TITRATION OF SERU’LIPOPROTEINS WITH LIPOPROTEIN PRECIPITANTS .(Ul DEC 81 0 A CLARK. J A

Thermal onset of cellular and endocrine stress responses correspond to ecological limits in brook trout, an iconic cold-water fish

USGS Publications Warehouse

Chadwick, Joseph G; Nislow, Kieth H; McCormick, Stephen

2015-01-01

Climate change is predicted to change the distribution and abundance of species, yet underlying physiological mechanisms are complex and methods for detecting populations at risk from rising temperature are poorly developed. There is increasing interest in using physiological mediators of the stress response as indicators of individual and population-level response to environmental stressors. Here, we use laboratory experiments to show that the temperature thresholds in brook trout (Salvelinus fontinalis) for increased gill heat shock protein-70 (20.7°C) and plasma glucose (21.2°C) are similar to their proposed thermal ecological limit of 21.0°C. Field assays demonstrated increased plasma glucose, cortisol and heat shock protein-70 concentrations at field sites where mean daily temperature exceeded 21.0°C. Furthermore, population densities of brook trout were lowest at field sites where temperatures were warm enough to induce a stress response, and a co-occurring species with a higher thermal tolerance showed no evidence of physiological stress at a warm site. The congruence of stress responses and proposed thermal limits supports the use of these thresholds in models of changes in trout distribution under climate change scenarios and suggests that the induction of the stress response by elevated temperature may play a key role in driving the distribution of species.

An evaluation of the precision of fin ray, otolith, and scale age determinations for brook trout

USGS Publications Warehouse

Stolarski, J.T.; Hartman, K.J.

2008-01-01

The ages of brook trout Salvelinus fontinalis are typically estimated using scales despite a lack of research documenting the effectiveness of this technique. The use of scales is often preferred because it is nonlethal and is believed to require less effort than alternative methods. To evaluate the relative effectiveness of different age estimation methodologies for brook trout, we measured the precision and processing times of scale, sagittal otolith, and pectoral fin ray age estimation techniques. Three independent readers, age bias plots, coefficients of variation (CV = 100 x SD/mean), and percent agreement (PA) were used to measure within-reader, among-structure bias and within-structure, among-reader precision. Bias was generally minimal; however, the age estimates derived from scales tended to be lower than those derived from otoliths within older (age > 2) cohorts. Otolith, fin ray, and scale age estimates were within 1 year of each other for 95% of the comparisons. The measures of precision for scales (CV = 6.59; PA = 82.30) and otoliths (CV = 7.45; PA = 81.48) suggest higher agreement between these structures than with fin rays (CV = 11.30; PA = 65.84). The mean per-sample processing times were lower for scale (13.88 min) and otolith techniques (12.23 min) than for fin ray techniques (22.68 min). The comparable processing times of scales and otoliths contradict popular belief and are probably a result of the high proportion of regenerated scales within samples and the ability to infer age from whole (as opposed to sectioned) otoliths. This research suggests that while scales produce age estimates rivaling those of otoliths for younger (age > 3) cohorts, they may be biased within older cohorts and therefore should be used with caution. ?? Copyright by the American Fisheries Society 2008.

Structure, metamorphism, and geochronology of the Cosmos Hills and Ruby Ridge, Brooks Range schist belt, Alaska