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Sample records for age optic disc

  1. Optical disc discrimination method

    NASA Astrophysics Data System (ADS)

    Nakahara, Hironori; Takeshita, Nobuo

    2015-09-01

    We propose a method for identifying the type of a disc inserted into an optical drive. The disc is irradiated with light from an LED light source and the diffracted light from the information recording layer of the disc is detected by using the movement of the disc during disc loading. Results of the optical simulation agree well with the experimental results. A total of 61 discs were measured, and it was confirmed that these discs can be distinguished accurately.

  2. Optical Disc Memory System

    NASA Astrophysics Data System (ADS)

    Imanaka, Ryoichi; Saimi, Tetsuo; Okazaki, Yukinori; Okino, Yoshihiro

    1983-11-01

    The video and the audio disc systems have been realized and the progress of optical disc memory systems allows the new products such as the video file system and the document file system. The optical disc memory system has a number of advantages compared with the current magnetic disc memory. These are the large recording capacity, the high recording density (10 to 100 times more than ordinary magnetic disc) and the contact free record and retrieval of the information, which eliminates the "Head Crush" problems and realizes the reliable information storage system. However, high recording density and small track pitches (usually 1.6--2.5 micron meters) increases the probability of error rate of recording infomation. Bit error rate (BER) of the recorded optical disc sometimes presents 10-4-10-5 Which is much higher than the magnetic disc. This high BER strongly depends on the production process. Optical disc is preformatted with the address information and with the tracks for infor-mation recording. The pregrooved disc used to be produced by the optical mastering process and the U-V replication process, which needs the very high-grade clean room and the expensive facilities. Process control of the laser cutting on the resist coated glass master is quite sensitive and must be treated with extreme care. When the large quantity of mass produced optical memory discs is supplied, a new mastering process would be needed. One of the solutions of this problem is the dry mastering process with a mechanical cutting system.

  3. Optical Coherence Tomography Angiography of Optic Disc Perfusion in Glaucoma

    PubMed Central

    Jia, Yali; Wei, Eric; Wang, Xiaogang; Zhang, Xinbo; Morrison, John C.; Parikh, Mansi; Lombardi, Lori H.; Gattey, Devin M.; Armour, Rebecca L.; Edmunds, Beth; Kraus, Martin F.; Fujimoto, James G.; Huang, David

    2014-01-01

    Purpose To compare optic disc perfusion between normal and glaucoma subjects using optical coherence tomography (OCT) angiography and detect optic disc perfusion changes in glaucoma. Design Observational, cross-sectional study. Participants Twenty-four normal subjects and 11 glaucoma patients were included. Methods One eye of each subject was scanned by a high-speed 1050 nm wavelength swept-source OCT instrument. The split-spectrum amplitude-decorrelation angiography algorithm (SSADA) was used to compute three-dimensional optic disc angiography. A disc flow index was computed from four registered scans. Confocal scanning laser ophthalmoscopy (cSLO) was used to measure disc rim area, and stereo photography was used to evaluate cup/disc ratios. Wide field OCT scans over the discs were used to measure retinal nerve fiber layer (NFL) thickness. Main Outcome Measurements Variability was assessed by coefficient of variation (CV). Diagnostic accuracy was assessed by sensitivity and specificity. Comparisons between glaucoma and normal groups were analyzed by Wilcoxon rank-sum test. Correlations between disc flow index, structural assessments, and visual field (VF) parameters were assessed by linear regression. Results In normal discs, a dense microvascular network was visible on OCT angiography. This network was visibly attenuated in glaucoma subjects. The intra-visit repeatability, inter-visit reproducibility, and normal population variability of the optic disc flow index were 1.2%, 4.2%, and 5.0% CV respectively. The disc flow index was reduced by 25% in the glaucoma group (p = 0.003). Sensitivity and specificity were both 100% using an optimized cutoff. The flow index was highly correlated with VF pattern standard deviation (R2 = 0.752, p = 0.001). These correlations were significant even after accounting for age, cup/disc area ratio, NFL, and rim area. Conclusions OCT angiography, generated by the new SSADA algorithm, repeatably measures optic disc perfusion. OCT angiography could be useful in the evaluation of glaucoma and glaucoma progression. PMID:24629312

  4. Optical Disc Applications in Libraries.

    ERIC Educational Resources Information Center

    Andre, Pamela Q. J.

    1989-01-01

    Discusses a variety of library applications of optical disc storage technology, including CD-ROM, digital videodisc, and WORM. Research and development projects at the Library of Congress, National Library of Medicine, and National Agricultural Library are described, products offered by library networks are reviewed, and activities in academic and…

  5. [Optic nerve disc drusen].

    PubMed

    Samoil?, O; C?lug?ru, D; C?lug?ru, M; Emese, Kaucsar

    2006-01-01

    Optic nerve head drusen represents a frequent condition, with unknown pathogenesis, mostly asymptomatic. Here, we present a patient with visual impairment, who has reacted well to anti-inflammatory and vasodilator treatment. PMID:16927754

  6. The Optical Disc Roundup.

    ERIC Educational Resources Information Center

    Galbreath, Jeremy

    1993-01-01

    Provides an update on optical disk technology as a means of digital media storage and explains why it may become a standard storage technology for telemedia technology. Topics discussed include read-only formats; write-once formats, including WORM and CD-WORM; rewritable formats; videodiscs; and future possibilities. (LRW)

  7. Computer animation via optical video disc

    E-print Network

    Bender, Walter

    1981-01-01

    This paper explores the notion of marrying two technologies: raster-scan computer animation and optical video discs. Animated sequences, generated at non real-time rates, then transfered to video disc, can be recalled under ...

  8. Glaucomatous-Type Optic Discs in High Myopia

    PubMed Central

    Nagaoka, Natsuko; Jonas, Jost B.; Morohoshi, Kei; Moriyama, Muka; Shimada, Noriaki; Yoshida, Takeshi; Ohno-Matsui, Kyoko

    2015-01-01

    Purpose To assess the prevalence of glaucoma in patients with high myopia defined as myopic refractive error of >-8 diopters or axial length ?26.5 mm. Methods The hospital-based observational study included 172 patients (336 eyes) with a mean age of 61.9±12.3 years and mean axial length of 30.1±2.3 mm (range: 24.7–39.1mm). Glaucomatous-type optic discs were defined by glaucomatous optic disc appearance. Glaucoma was defined by glaucomatous optic disc appearance and glaucomatous Goldmann visual field defects not corresponding with myopic macular changes. Results Larger disc area (mean: 3.18±1.94 mm2) was associated with longer axial length (P<0.001; standardized correlation coefficient: 0.45). Glaucoma was detected in 94 (28%; 95% Confidence intervals: 23%, 33%) eyes. In multivariate analysis, glaucoma prevalence was 3.2 times higher (P<0.001) in megalodiscs (>3.79 mm2) than in normal-sized discs or small discs (<1.51 mm2) after adjusting for older age. Axial length was not significantly (P = 0.38) associated with glaucoma prevalence in that model. Glaucoma prevalence increased by a factor of 1.39 for each increase in optic disc area by one mm2. Again, axial length was not significantly (P = 0.38) associated with glaucoma prevalence when added to this multivariate model. Conclusion Within highly myopic individuals, glaucoma prevalence increased with larger optic disc size beyond a disc area of 3.8 mm2. Highly myopic megalodiscs as compared to normal sized discs or small discs had a 3.2 times higher risk for glaucomatous optic nerve neuropathy. The increased glaucoma prevalence in axial high myopia was primarily associated with axial myopia associated disc enlargement and not with axial elongation itself. PMID:26425846

  9. Optic disc anomalies and frontonasal dysplasia

    PubMed Central

    Hodgkins, P; Lees, M; Lawson, J; Reardon, W; Leitch, J; Thorogood, P; Winter, R; Taylor, D

    1998-01-01

    AIMS—To document the optic disc abnormalities in patients with frontonasal dysplasia in association with basal encephalocele.?METHODS—Names and hospital numbers of patients with midline clefts were obtained from the ophthalmology and genetics database. Six patients were identified who had the following common findings: midline facial cleft with midline cleft lip and palate; hypertelorism; absent corpus callosum; basal (sphenoethmoidal) encephalocele; and pituitary deficiency (five out of six cases). Ophthalmic examination was performed with fundal photography where possible.?RESULTS—Two patients had unilateral and one a bilateral peripapillary staphyloma. Two patients had bilateral optic disc hypoplasia and one appeared to have a peripapillary staphyloma in one eye and a morning glory disc in the other.?CONCLUSION—Optic disc abnormalities were found in all patients with this constellation of clinical findings. This association appears to represent a distinct subgroup within the spectrum of frontonasal dysplasia. The presence of midline facial anomalies and any dysplastic disc should alert the physician as to the presence of an encephalocele.?? Keywords: frontonasal dysplasia; optic disc; encephalocele PMID:9602627

  10. Optic Disc - Fovea Angle: The Beijing Eye Study 2011

    PubMed Central

    Jonas, Rahul A.; Wang, Ya Xing; Yang, Hua; Li, Jian Jun; Xu, Liang; Panda-Jonas, Songhomitra; Jonas, Jost B.

    2015-01-01

    Purpose To determine the optic disc-fovea angle (defined as angle between the horizontal and the line between the optic disc center and the fovea) and to assess its relationships with ocular and systemic parameters. Methods The population-based cross-sectional Beijing Eye Study 2011 included 3468 individuals. A detailed ophthalmic examination was carried out. Using fundus photographs, we measured the disc-fovea angle. Results Readable fundus photographs were available for 6043 eyes of 3052 (88.0%) individuals with a mean age of 63.6±9.3 years (range: 50–91 years) and a mean axial length of 23.2±1.0 mm (range: 18.96–28.87 mm). Mean disc-fovea angle was 7.76 ± 3.63° (median: 7.65°; range: -6.3° to 28.9°). The mean inter-eye difference was 4.01 ± 2.94° (median: 3.49°; range: 0.00–22.3°). In multivariate analysis, larger disc-fovea angle was associated (regression coefficient r2: 0.08) with older age (P = 0.009; standardized regression coefficient beta: 0.05), thinner RNFL in the nasal superior sector (P<0.001; beta: -0.17), superior sector (P<0.001; beta: -0.10) and temporal superior sector (P<0.001; beta: -0.11) and thicker RNFL in the inferior sector (P<001; beta: 0.13), nasal inferior sector (P<001; beta: 0.13) and nasal sector (P = 0.007; beta: 0.06), higher prevalence of retinal vein occlusion (P = 0.02; beta: 0.04), and with larger cylindrical refractive error (P = 0.04; beta: 0.04). Conclusions The optic disc-fovea angle markedly influences the regional distribution of the RNFL thickness pattern. The disc-fovea angle may routinely be taken into account in the morphological glaucoma diagnosis and in the assessment of structure-function relationship in optic nerve diseases. Future studies may address potential associations between a larger disc-fovea angle and retinal vein occlusions and between the disc-fovea angle and the neuroretinal rim shape. PMID:26545259

  11. Archival-grade optical disc design and international standards

    NASA Astrophysics Data System (ADS)

    Fujii, Toru; Kojyo, Shinichi; Endo, Akihisa; Kodaira, Takuo; Mori, Fumi; Shimizu, Atsuo

    2015-09-01

    Optical discs currently on the market exhibit large variations in life span among discs, making them unsuitable for certain business applications. To assess and potentially mitigate this problem, we performed accelerated degradation testing under standard ISO conditions, determined the probable disc failure mechanisms, and identified the essential criteria necessary for a stable disc composition. With these criteria as necessary conditions, we analyzed the physical and chemical changes that occur in the disc components, on the basis of which we determined technological measures to reduce these degradation processes. By applying these measures to disc fabrication, we were able to develop highly stable optical discs.

  12. Basics of videodisc and optical disc technology

    SciTech Connect

    Paris, J.

    1983-11-01

    The optical videodisc is now being used for archival storage of photographs and for records management. The spacedisc project, co-sponsored by nasa and drew university's center for aerospace education, is a prime example of using a videodisc to store individual photographs, slides, and motion sequences with an accompanying paper index. These discs are also used in schools in an interactive individualized learning carrel under microcomputer control. Museums also are using discs as complements to exhibits as well as in cataloging and in classification, information storage and retrieval systems. Ongoing imaginative applications of the optical videodisc include surrogate travel, job performance aids, simulators, electronic malls, and travelogues. Eventually, one will see the videodisc and computer technology with artificial intelligence programs used by the medical community and others. Optical disc and videodisc technology have opened up new horizons for information processing, storage and retrieval, education and training. Regardless of whether a mass consumer market materializes, optical recording technology will play a major role in the future design and development of information systems in the late 1980s and beyond.

  13. Dependence of optic disc parameters on disc area according to Heidelberg Retina Tomograph: Part II.

    NASA Astrophysics Data System (ADS)

    Machekhin, V.; Manaenkova, G.; Bondarenko, O.

    2007-05-01

    With the help of Heidelberg Retina Tomograph (HRT-II) optic disc parameters in 211 eyes of 115 healthy patients with refraction Em +/- 3,0 D and 96 eyes of 72 patients with myopia 3,5-14,0 D without any signs of glaucoma were studied. Analysis of optic disc parameters were carried out in 5 groups of patients according to disc area: less than 1,5 mm2, 1,5- 2,5 mm2, 2,5-3,0 mm2, 3,0-3,5 mm2 and more than 3,5 mm2. An accurate depending on disc area was revealed for all optic disc parameters in all sectors, which was manifested by increasing cup disc and rim disc (area and volume) and other parameters. We consider it is necessary to use the proper tables for right interpretation of received data for early diagnosis of glaucoma.

  14. Interactive Optical Disc Systems: Part 1: Analog Storage.

    ERIC Educational Resources Information Center

    Hessler, David W.

    1984-01-01

    Details distinction between digital and analog data, advantages of analog storage, and optical disc use to store analog data. Configuration and potential of three levels of laser disc systems are explained. Selection of display devices for use with laser disc systems and accessing audio data are addressed. (Continued in next issue.) (EJS)

  15. The optic disc is minimal in children with idiopathic intracranial hypertension.

    PubMed

    Dai, Shuan; Trimboli, Carmelina; Buncic, J Raymond

    2013-10-01

    This study sought to characterize the optic disc morphology, particularly the cup-to-disc ratio of the optic nerve head in children with idiopathic intracranial hypertension. The medical charts and digital optic disc photos of children with confirmed diagnosis of idiopathic intracranial hypertension were reviewed retrospectively. The optic disc area, cup area, and cup-to-disc ratio were measured digitally using VISUPAC software, and the mean values of those parameters were compared to the published norms. Of children with idiopathic intracranial hypertension, 83% had absence of the physiological cup of the optic disc, compared to 10% of children in the general population of the same age. The median disc area was 2.2 mm(2), and median cup area was 0.0mm(2), compared to the published norms of 2.69 mm(2) and 0.44 mm(2), respectively. There is very significantly high prevalence of small optic disc cups in children with idiopathic intracranial hypertension, with the cup being absent on majority of cases in our patient cohort. This may signal an underlying systemic predisposition to the development of intracranial hypertension. PMID:23034982

  16. The age of Taurus - environmental effects on disc lifetimes

    E-print Network

    Rees, Jon M; Bell, C P M; Jeffries, R D; Naylor, Tim

    2015-01-01

    Using semi-empirical isochrones, we find the age of the Taurus star-forming region to be 3-4 Myr. Comparing the disc fraction in Taurus to young massive clusters suggests discs survive longer in this low density environment. We also present a method of photometrically de-reddening young stars using $iZJH$ data.

  17. Clinical measurement and categorization of optic disc in glaucoma patients

    PubMed Central

    Rao, Harsha B L; Sekhar, G C; Babu, Ganesh J; Parikh, Rajul S

    2009-01-01

    Background: Assessment of optic disc size is an important component of optic nerve head examination. Agreement between different methods of disc size measurements is not very good. Purpose: To assess the agreement between the disc size assessed by Heidelberg retina tomograph (HRT) and stereobiomicroscopy with a 90 diopter (D) lens. To report the clinical (measured by biomicroscopy) disc diameters of small, average and large optic discs categorized by HRT disc areas. Setting and Design: Observational study of subjects examined in the glaucoma clinic of a tertiary eye institute. Materials and Methods: Seventy-five eyes of 75 glaucoma subjects were studied. Disc diameter was measured using stereobiomicroscopy and HRT. The agreement between the two sets of measurements was assessed by intraclass correlation coefficient (ICC). Discs were classified into small (<1.6 mm2), average (1.6-2.6 mm2) and large (>2.6 mm2) depending on cutoffs provided by the manufacturers of HRT. The means (95% CI) of the corresponding vertical disc diameter in these groups were assessed. Statistical Analysis: ICC, Bland and Altman plots. Results: ICC for measurements of clinical and HRT horizontal disc diameter was 0.518 and for vertical disc diameter measurement was 0.487. The mean difference between the clinical and HRT measurements as analyzed by the Bland and Altman plot was 0.17 (95% CI, 0.13- 0.47) for horizontal and 0.22 (95% CI, 0.11- 0.54) for vertical disc diameter. Of the 75 eyes, 3 eyes had small discs, 54 average and 18 large discs. The mean clinical vertical disc diameter for small discs was 1.55 mm (95% CI, 1.2-1.7), for average discs was 1.91 mm (95% CI, 1.87-1.96) and for large discs was 2.15 mm (95% CI, 2.03–2.27). Conclusion: The agreement between clinical and HRT disc diameter measurements is moderate. Disc diameter measurement on stereobiomicroscopy can be used to categorize discs into small, average and large discs. PMID:19700874

  18. Reappraisal of the ratio of disc to macula/disc diameter in optic nerve hypoplasia.

    PubMed Central

    Zeki, S M; Dudgeon, J; Dutton, G N

    1991-01-01

    The ratio of disc to macula/disc diameter is characteristically increased in eyes with optic nerve hypoplasia. We present the largest reported series of patients with a definitive diagnosis of optic nerve hypoplasia for whom this ratio has been determined. All measurements were made by an independent masked observer. Our results are in accordance with previous reports. A ratio of 2.94 provides a one-tailed upper population limit of 95%. An attempt has been made to correlate optic disc size and visual acuity. In 75% of bilateral cases the eye with the relatively smaller optic disc was found to have a better Snellen visual acuity than the fellow eye. This suggests that additional pathogenic mechanism(s) may have determined the eventual visual outcome in such eyes. Such mechanisms include macular hypoplasia, high refractive error, refractive amblyopia, central scotoma, and optic atrophy. Images PMID:1911656

  19. Optic Disc Change during Childhood Myopic Shift: Comparison between Eyes with an Enlarged Cup-To-Disc Ratio and Childhood Glaucoma Compared to Normal Myopic Eyes

    PubMed Central

    Park, Hae-Young Lopilly; Kim, Sung Eum; Park, Chan Kee

    2015-01-01

    Background Progressive disc tilting and the development or enlargement of peripapillary atrophy (PPA) are observed during a myopic shift in children. This could be related to the changes around the optic nerve head during eyeball elongation. If the biomechanical properties at or around the optic nerve head are changed after exposure to elevated intraocular pressure (IOP) in glaucoma eyes, different response of the disc tilting and PPA changes could take place during eyeball elongation by myopic shift. On the basis of this background, the aim of this study was to compare the morphological changes in the optic disc induced by a myopic shift during childhood between normal control eyes, eyes from disc suspects with an enlarged cup-to-disc ratio (CDR), and eyes with childhood glaucoma. Methods Total of 82 eyes from 82 subjects younger than 14 years of age were included in the study. Serial disc photographs were classified into one of two groups: eyes with an optic nerve head (ONH) or peripapillary atrophy (PPA) change or without an ONH/PPA change. Using ImageJ software, the outlines of the optic disc and PPA were plotted, and the vertical disc diameter (VDD), horizontal disc diameter (HDD), and maximum PPA width (PPW) were measured. The changes in the ratios of these parameters and the relationships between the degree of myopic shift or the ONH/PPA change were analyzed. Results Twenty-five eyes with normal optic disc appearance, 36 eyes with enlarged cup-to-disc ratio, and 21 eyes of glaucoma patients were analyzed. The initial intraocular pressure (IOP) at diagnosis was significantly different among the groups (P<0.001). The degree of myopic shift during follow-up period was not significantly different among the groups (P=0.612). However, the changes in the HDD/VDD and PPW/VDD ratios were significantly greater in the disc suspect group and significantly smaller in the glaucoma group. Among the 42 eyes with an ONH/PPA change, 16 (38.1%) were from the normal control group, 24 (57.1%) were from the disc suspect group, and 2 (4.8%) were from the glaucoma group (P < 0.001). Conclusions and Relevance The optic disc change during childhood myopic shift was different in eyes with various conditions. Eyes of childhood glaucoma showed less change in the disc morphology during myopic shift compared to eyes with normal disc or enlarged cup-to-disc ratio. PMID:26147983

  20. Multilayer optical disc system using homodyne detection

    NASA Astrophysics Data System (ADS)

    Kurokawa, Takahiro; Ide, Tatsuro; Tanaka, Yukinobu; Watanabe, Koichi

    2014-09-01

    A write/read system using high-productivity multilayer optical discs was developed. The recording medium used in the system consists of planar recording layers and a separated guide layer, and is fabricated by web coating and lamination process. The recording layers in the medium are made of one-photon-absorption material, on which data can be recorded with a normal laser diode. The developed system is capable of focusing and tracking on the medium and amplifying readout signals by using phase-diversity homodyne detection. A highly layer-selective focusing method using homodyne detection was also proposed. This method obtains stable focus-error signals with clearly separated S-shaped curves even when layer spacing is quite narrow, causing large interlayer crosstalk. Writing on the medium and reading with the signal amplification effect of homodyne detection was demonstrated. In addition, the effectiveness of the method was experimentally evaluated.

  1. Optic disc detection using ant colony optimization

    NASA Astrophysics Data System (ADS)

    Dias, Marcy A.; Monteiro, Fernando C.

    2012-09-01

    The retinal fundus images are used in the treatment and diagnosis of several eye diseases, such as diabetic retinopathy and glaucoma. This paper proposes a new method to detect the optic disc (OD) automatically, due to the fact that the knowledge of the OD location is essential to the automatic analysis of retinal images. Ant Colony Optimization (ACO) is an optimization algorithm inspired by the foraging behaviour of some ant species that has been applied in image processing for edge detection. Recently, the ACO was used in fundus images to detect edges, and therefore, to segment the OD and other anatomical retinal structures. We present an algorithm for the detection of OD in the retina which takes advantage of the Gabor wavelet transform, entropy and ACO algorithm. Forty images of the retina from DRIVE database were used to evaluate the performance of our method.

  2. Pathogenesis of optic disc edema in raised intracranial pressure.

    PubMed

    Hayreh, Sohan Singh

    2016-01-01

    Optic disc edema in raised intracranial pressure was first described in 1853. Ever since, there has been a plethora of controversial hypotheses to explain its pathogenesis. I have explored the subject comprehensively by doing basic, experimental and clinical studies. My objective was to investigate the fundamentals of the subject, to test the validity of the previous theories, and finally, based on all these studies, to find a logical explanation for the pathogenesis. My studies included the following issues pertinent to the pathogenesis of optic disc edema in raised intracranial pressure: the anatomy and blood supply of the optic nerve, the roles of the sheath of the optic nerve, of the centripetal flow of fluids along the optic nerve, of compression of the central retinal vein, and of acute intracranial hypertension and its associated effects. I found that, contrary to some previous claims, an acute rise of intracranial pressure was not quickly followed by production of optic disc edema. Then, in rhesus monkeys, I produced experimentally chronic intracranial hypertension by slowly increasing in size space-occupying lesions, in different parts of the brain. Those produced raised cerebrospinal fluid pressure (CSFP) and optic disc edema, identical to those seen in patients with elevated CSFP. Having achieved that, I investigated various aspects of optic disc edema by ophthalmoscopy, stereoscopic color fundus photography and fluorescein fundus angiography, and light microscopic, electron microscopic, horseradish peroxidase and axoplasmic transport studies, and evaluated the effect of opening the sheath of the optic nerve on the optic disc edema. This latter study showed that opening the sheath resulted in resolution of optic disc edema on the side of the sheath fenestration, in spite of high intracranial CSFP, proving that a rise of CSFP in the sheath was the essential pre-requisite for the development of optic disc edema. I also investigated optic disc edema with raised CSFP in patients, by evaluating optic disc and fundus changes by stereoscopic fundus photography and fluorescein fundus angiography. Based on the combined information from all the studies discussed above, it is clear that the pathogenesis of optic disc edema in raised intracranial pressure is a mechanical phenomenon. It is primarily due to a rise of CSFP in the optic nerve sheath, which produces axoplasmic flow stasis in the optic nerve fibers in the surface nerve fiber layer and prelaminar region of the optic nerve head. Axoplasmic flow stasis then results in swelling of the nerve fibers, and consequently of the optic disc. Swelling of the nerve fibers and of the optic disc secondarily compresses the fine, low-pressure venules in that region, resulting in venous stasis and fluid leakage; that leads to the accumulation of extracellular fluid. Contrary to the previous theories, the various vascular changes seen in optic disc edema are secondary and not primary. Thus, optic disc edema in raised CSFP is due to a combination of swollen nerve fibers and the accumulation of extracellular fluid. My studies also provided information about the pathogeneses of visual disturbances in raised intracranial pressure. PMID:26453995

  3. Exploring the vertical age structure of the Galactic disc

    NASA Astrophysics Data System (ADS)

    Casagrande, Luca; Silva Aguirre, Victor; Schlesinger, Katharine J.; Stello, Dennis; Huber, Daniel; Serenelli, Aldo; Schoenrich, Ralph; Asplund, Martin; Feltzing, Sofia

    2015-08-01

    While in external or high-redshift galaxies we can only measure integrated stellar properties at best, the Milky Way offers us the unique opportunity to study its individual baryonic components, including stars. We use oscillations measured in giant stars by the Kepler satellite to derive stellar ages and explore the vertical age structure across few kpc of the Milky Way disc. We find that old stars dominate at increasing Galactic heights, whereas closer to the plane a rich zoology of ages exists. The age distribution of stars shows a smooth decline over the last 10 Gyr, which together with a flat age-metallicity relation is consistent with a quiescent evolution for the Milky Way disc since a redshift of about two.

  4. Bilateral peripapillary serous retinal detachment in association with congenital optic disc pits.

    PubMed

    Shafi, Aabgina; Twaij, Suhair; Ibraheim, A

    2013-01-01

    A middle-aged asymptomatic patient was referred to the eye clinic by her optician because of unusual optic nerve heads. She was found to have optic disc pits with bilateral serous retinal detachments which were non-progressive. She did not need any treatment and was safely followed up in the community. This uncommon condition is discussed along with possible pathophysiology and treatment. PMID:23417933

  5. Thermal and Optical Properties of Metal Azo Dyes for Digital Video Disc-Recordable Discs

    NASA Astrophysics Data System (ADS)

    Suzuki, Yuki; Horie, Michikazu; Okamoto, Yuuko; Kurose, Yutaka; Maeda, Shuichi

    1998-04-01

    The effects of the optical and thermal properties of metal azo dyes on the recording characteristics of digital video disc-recordable (DVD-R) discs have been studied. A sharp threshold for thermal decomposition of the dye assures a clear mark edge and low jitter for the minimum mark length of 0.4 0.44 µm. A steep absorption edge at the 635 nm side is also critical to high reflectivity and for fabricating clear mark edges. Following these guidelines, excellent 0.4 µm shortest mark length recording characteristics are achieved with original metal azo dye.

  6. Lamina Cribrosa Defects and Optic Disc Morphology in Primary Open Angle Glaucoma with High Myopia

    PubMed Central

    Kimura, Yugo; Akagi, Tadamichi; Hangai, Masanori; Takayama, Kohei; Hasegawa, Tomoko; Suda, Kenji; Yoshikawa, Munemitsu; Yamada, Hiroshi; Nakanishi, Hideo; Unoki, Noriyuki; Ikeda, Hanako Ohashi; Yoshimura, Nagahisa

    2014-01-01

    Purpose To investigate whether lamina cribrosa (LC) defects are associated with optic disc morphology in primary open angle glaucoma (POAG) eyes with high myopia. Methods A total of 129 POAG patients and 55 age-matched control subjects with high myopia were evaluated. Three-dimensional scan images obtained by swept source optical coherence tomography were used to detect LC defects. Radial B-scans and infrared images obtained by spectral domain optical coherence tomography were used to measure ?-peripapillary atrophy (PPA) lengths with and without Bruch's membrane (BM) (temporal, nasal, superior, and inferior), tilt angle (vertical and horizontal), and disc diameter (transverse and longitudinal). Peripapillary intrachoroidal cavitations (PICCs), disc area, ovality index, and cyclotorsion of the optic disc were analyzed as well. Results LC defects were found in 70 of 129 (54.2%) POAG eyes and 1 of 55 (1.8%) control eyes (P<0.001). Age, sex, spherical equivalent, axial length, intraocular pressure, and central corneal thickness were not significantly different among POAG eyes with LC defects, POAG eyes without LC defects, and control eyes. Temporal PPA lengths without BM in all three groups correlated significantly with vertical and horizontal tilt angles, although no PPA length with BM correlated significantly with any tilt angle. PICCs were detected more frequently in POAG eyes with LC defects than those without LC defects (P?=?0.01) and control eyes (P?=?0.02). POAG eyes with LC defects showed a smaller ovality index (P?=?0.004), longer temporal PPA without BM (P<0.001), and larger vertical/horizontal tilt angles (vertical, P<0.001; horizontal, P?=?0.01), and transverse diameter (P?=?0.01). In multivariate analysis for the presence of LC defects, presence of POAG (P<0.001) and vertical tilt angle (P<0.001) were identified as significant. Conclusions The presence of LC defects was associated with myopic optic disc morphology in POAG eyes with high myopia. PMID:25531656

  7. Familial Disorders of the Optic Disc: Presentation of a Mother and Daughter and Review of the Literature

    PubMed Central

    Hsu, Chia Lee; Layton, Christopher J.

    2015-01-01

    Optic disc pit and optic nerve coloboma are examples of congenital optic disc abnormalities. Although optic nerve coloboma can be inherited in an autosomal dominant fashion, no conclusive link has been found in the case of optic disc pit as an autosomal dominant disease. We describe two cases: a daughter with an optic disc pit complicated by maculopathy and her mother with a congenitally abnormal optic disc complicated by peripapillary choroidal neovascularisation. PMID:26327911

  8. Familial Disorders of the Optic Disc: Presentation of a Mother and Daughter and Review of the Literature.

    PubMed

    Hsu, Chia Lee; Layton, Christopher J

    2015-01-01

    Optic disc pit and optic nerve coloboma are examples of congenital optic disc abnormalities. Although optic nerve coloboma can be inherited in an autosomal dominant fashion, no conclusive link has been found in the case of optic disc pit as an autosomal dominant disease. We describe two cases: a daughter with an optic disc pit complicated by maculopathy and her mother with a congenitally abnormal optic disc complicated by peripapillary choroidal neovascularisation. PMID:26327911

  9. Low-cost ultrahigh areal density optical disc system towards 400 Gbyte/disc

    NASA Astrophysics Data System (ADS)

    Morimoto, Yoshitaka; Kurokawa, Takahiro; Kikukawa, Atsushi; Watanabe, Koichi; Chiba, Zenjiro; Takeshima, Hideharu; Matsuda, Isao; Kojyo, Shinichi; Shimomai, Kenichi; Fujii, Toru

    2015-09-01

    We introduce a new 400 Gbyte disc system, which has twice as much areal density as BDXL™ does, retaining the use of the conventional optical head and disc technology. Our proposal is based on the application of code modulations with enlarged minimum run length (d) and land/groove (L/G) geometry to increase linear recording density and track density by 1.5 and 1.33 times, respectively. Also, saw tooth wobble (STW) was introduced for a multilayered L/G disc system to suppress readout signal fluctuations. Here, we demonstrated that the linear recording density increased to 45.5 Gbyte/layer by applying d = 3 to a commercially available BDXL™. Also, we checked that crosstalk, which is a major concern in an L/G disc with a track pitch of 240 nm, was suppressed to below -30 dB by choosing the proper groove depth. Moreover, the investigation of the effect of track width modulation on the write/read performance demonstrated that an adverse influence can be suppressed by employing STW.

  10. Fundus optic disc localization and segmentation method based on phase congruency.

    PubMed

    Geng, Lei; Shao, Yi-Ting; Xiao, Zhi-Tao; Zhang, Fang; Wu, Jun; Li, Min; Shan, Chun-Yan

    2014-01-01

    It has been demonstrated that shape, area and depth of the optic disc are relevant indices of diabetic retinopathy. In this paper, we present a new fundus optic disc localization and segmentation method based on phase congruency (PC). Firstly, in order to highlight the optic disc, channel images with the highest contrast between optic disc and background are selected in LAB, YUV, YIQ and HSV spaces respectively. Secondly, with the use of PC, features of four selected channel images can be extracted. Multiplication operation is then used to enhance PC detection results. Thirdly, window scanning and gray accumulating are utilized to locate the optic disc. Finally, iterative OTSU automatic threshold segmentation and Hough transform are performed on location images, before the final optic disc segmentation result can be obtained. The experimental results showed that the proposed method can effectively and accurately perform optic disc location and segmentation. PMID:25227031

  11. An unusual cause for an optic disc haemorrhage

    PubMed Central

    Baxter, Julia; Kailasanathan, Anusha; Chen, Hean

    2011-01-01

    A 51-year-old male on chemotherapy for myeloma presented initially with a unilateral optic disc haemorrhage and signs of optic neuropathy. This rapidly progressed to affect both eyes and within a few days he developed retinal features suggestive of progressive outer retinal necrosis. He was treated with intravenous acyclovir that was subsequently changed to ganciclovir when serological tests for cytomegalovirus were found to be positive for immunoglobulin M antibodies. His visual loss continued to deteriorate despite treatment, and he subsequently developed a retinal detachment in one eye. The causes of optic neuropathy in immunocompromised patients and the importance of eliminating an infective cause are discussed. PMID:22707367

  12. Optic Disc - Fovea Distance, Axial Length and Parapapillary Zones. The Beijing Eye Study 2011

    PubMed Central

    Jonas, Rahul Arvo; Wang, Ya Xing; Yang, Hua; Li, Jian Jun; Xu, Liang; Panda-Jonas, Songhomitra; Jonas, Jost Bruno

    2015-01-01

    Purpose To measure the distance between the optic disc center and the fovea (DFD) and to assess its associations. Methods The population-based cross-sectional Beijing Eye Study 2011 included 3468 individuals aged 50+ years. The DFD was measured on fundus photographs. Results Readable fundus photographs were available for 2836 (81.8%) individuals. Mean DFD was 4.76 ± 0.34mm (median: 4.74 mm; range: 3.76–6.53mm). In multivariate analysis, longer DFD was associated with longer axial length (P<0.001; standardized correlation coefficient beta: 0.62), higher prevalence of axially high myopia (P<0.001; beta:0.06), shallower anterior chamber depth (P<0.001; beta:-0.18), thinner lens thickness (P = 0.004; beta: -0.06), smaller optic disc-fovea angle (P = 0.02; beta: -0.04), larger parapapillary alpha zone (P = 0.008; beta: 0.05), larger parapapillary beta/gamma zone (P<0.001; beta: 0.11), larger optic disc area (P<0.001; beta: 0.08), lower degree of cortical cataract (P = 0.002; beta: -0.08), and lower prevalence of age-related macular degeneration (P = 0.001; beta: -0.06). Bruch´s membrane opening-fovea distance (DFD minus disc radius minus parapapillary beta/gamma zone width) in non-glaucomatous eyes was not significantly (P = 0.60) related with axial length in emmetropic or axially myopic eyes (axial length ?23.5 mm), while it increased significantly (P<0.001; r: 0.32) with longer axial length in eyes with an axial length of <23.5mm. Ratio of mean DFD to disc diameter was 2.65 ± 0.30. If the ratio of disc-fovea distance to disc diameter was considered constant and if the individual disc diameter was calculated as the individual disc-fovea distance divided by the constant factor of 2.65, the resulting calculated disc diameter differed from the directly measured disc diameter by 0.16 ±0.13 mm (median: 0.13 mm, range: 0.00–0.89 mm) or 8.9 ± 7.3% (median: 7.4%; range: 0.00–70%) of the measured disc diameter. Conclusions DFD (mean: 4.76mm) increases with longer axial length, larger parapapillary alpha zone and parapapillary beta/gamma zone, and larger disc area. The axial elongation associated increase in DFD was due to an enlargement of parapapillary beta/gamma zone while the Bruch’s membrane opening-fovea distance did not enlarge with longer axial length. This finding may be of interest for the process of emmetropization and myopization. Due to its variability, the disc-fovea distance has only limited clinical value as a relative size unit for structures at the posterior pole. PMID:26390438

  13. Optic Disc and Optic Cup Segmentation Methodologies for Glaucoma Image Detection: A Survey

    PubMed Central

    Almazroa, Ahmed; Burman, Ritambhar; Raahemifar, Kaamran; Lakshminarayanan, Vasudevan

    2015-01-01

    Glaucoma is the second leading cause of loss of vision in the world. Examining the head of optic nerve (cup-to-disc ratio) is very important for diagnosing glaucoma and for patient monitoring after diagnosis. Images of optic disc and optic cup are acquired by fundus camera as well as Optical Coherence Tomography. The optic disc and optic cup segmentation techniques are used to isolate the relevant parts of the retinal image and to calculate the cup-to-disc ratio. The main objective of this paper is to review segmentation methodologies and techniques for the disc and cup boundaries which are utilized to calculate the disc and cup geometrical parameters automatically and accurately to help the professionals in the glaucoma to have a wide view and more details about the optic nerve head structure using retinal fundus images. We provide a brief description of each technique, highlighting its classification and performance metrics. The current and future research directions are summarized and discussed. PMID:26688751

  14. Ultracool white dwarfs and the age of the Galactic disc

    NASA Astrophysics Data System (ADS)

    Gianninas, A.; Curd, B.; Thorstensen, John R.; Kilic, Mukremin; Bergeron, P.; Andrews, Jeff J.; Canton, Paul; Agüeros, M. A.

    2015-06-01

    We present parallax observations and a detailed model atmosphere analysis of 54 cool and ultracool (Teff < 4000 K) white dwarfs (WDs) in the solar neighbourhood. For the first time, a large number of cool and ultracool WDs have distance and tangential velocities measurements available. Our targets have distances ranging from 21 pc to >100 pc, and include five stars within 30 pc. Contrary to expectations, all but two of them have tangential velocities smaller than 150 km s-1 thus suggesting Galactic disc membership. The oldest WDs in this sample have WD cooling ages of 10 Gyr, providing a firm lower limit to the age of the thick disc population. Many of our targets have uncharacteristically large radii, indicating that they are low-mass WDs. It appears that we have detected the brighter population of cool and ultracool WDs near the Sun. The fainter population of ultracool CO-core WDs remain to be discovered in large numbers. The Large Synoptic Survey Telescope should find these elusive, more massive ultracool WDs in the solar neighbourhood.

  15. Dissecting simulated disc galaxies - II. The age-velocity relation

    NASA Astrophysics Data System (ADS)

    Martig, Marie; Minchev, Ivan; Flynn, Chris

    2014-09-01

    We study the relation between stellar ages and vertical velocity dispersion (the age-velocity relation, or AVR) in a sample of seven simulated disc galaxies. In our simulations, the shape of the AVR for stars younger than 9 Gyr depends strongly on the merger history at low redshift, with even 1:10-1:15 mergers being able to create jumps in the AVR (although these jumps might not be detectable if the errors on stellar ages are of the order of 30 per cent). For galaxies with a quiescent history at low redshift, we find that the vertical velocity dispersion rises smoothly for ages up to 8-9 Gyr, following a power law with a slope of ˜0.5, similar to what is observed in the solar neighbourhood by the Geneva-Copenhagen Survey. For these galaxies, we show that the slope of the AVR is not imprinted at birth, but is the result of subsequent heating. By contrast, in all our simulations, the oldest stars form a significantly different population, with a high velocity dispersion. These stars are usually born kinematically hot in a turbulent phase of intense mergers at high redshift, and also include some stars accreted from satellites. This maximum in ?z is strongly decreased when age errors are included, suggesting that observations can easily miss such a jump with the current accuracy of age measurements.

  16. Optical forces near subwavelength apertures in metal discs

    NASA Astrophysics Data System (ADS)

    Blanco, L. A.; Nieto-Vesperinas, M.

    2007-08-01

    We study the transmitted intensity and induced photonic forces on interaction of light with a metallic disc containing a circular aperture. A procedure is used to calculate light transmission through the aperture, discussing the role of its morphological resonances. The resulting optical forces on metallic spheres placed in front of the aperture in the transmission side are analysed, observing that they yield a possible means of trapping, with particle size, position and composition discrimination, as a consequence of the force different signs and magnitudes as the wavelength varies.

  17. Cup to disc ratio by optical coherence tomography is abnormal in Multiple Sclerosis

    PubMed Central

    Syc, S.B.; Warner, C.V.; Saidha, S.; Farrell, S.K.; Conger, A.; Bisker, E.R.; Wilson, J.; Frohman, E.M.; Balcer, L.J.; Calabresi, P.A.

    2010-01-01

    Objective To identify and characterize cup to disc ratio (CDR) and related optic nerve head abnormalities in multiple sclerosis (MS) using spectral domain optical coherence tomography (OCT). Background While CDR is routinely assessed by ophthalmologists in the evaluation of glaucoma, CDR and related optic nerve head metrics remain largely unexplored in MS. Design/Methods Cirrus-HD (high density) OCT was used to evaluate average CDR, vertical CDR, optic disc area, optic cup volume and neuro-retinal rim area in 105 MS patients and 88 age-matched healthy individuals. High-contrast (100%) visual acuity, 2.5% low-contrast letter acuity and 1.25% low-contrast letter acuity were assessed in 77 MS patients. Two-sample t-tests were used in the analysis of OCT-derived optic nerve head measures between healthy controls and MS patients. Multivariate regression (accounting for age and gender) was used to assess relationships between optic nerve head measures and visual function. Results Average CDR (p=0.007) and vertical CDR (p=0.005) was greater in MS patients compared to healthy controls, while neuro-retinal rim area was decreased in MS patients (p=0.001). CDR increased with retinal nerve fiber layer (RNFL) thinning (r=?0.29, p=0.001). 2.5% low-contrast (p=0.005) and 1.25% low-contrast letter acuity (p=0.03) were lower in MS patients with higher vertical CDR. Conclusions/Relevance CDR (as determined by spectral domain OCT), is abnormal in MS and correlates with visual function. OCT derived CDR and related optic nerve head metrics may represent an objective measure by which to monitor disease progression, and potentially neuroprotection, in therapeutic MS trials. PMID:21227470

  18. Automatic optic disc detection in OCT slices via low-rank reconstruction.

    PubMed

    Fu, Huazhu; Xu, Dong; Lin, Stephen; Wong, Damon Wing Kee; Liu, Jiang

    2015-04-01

    Optic disc measurements provide useful diagnostic information as they have correlations with certain eye diseases. In this paper, we provide an automatic method for detecting the optic disc in a single OCT slice. Our method is developed from the observation that the retinal pigment epithelium (RPE) which bounds the optic disc has a low-rank appearance structure that differs from areas within the disc. To detect the disc, our method acquires from the OCT image an RPE appearance model that is specific to the individual and imaging conditions, by learning a low-rank dictionary from image areas known to be part of the RPE according to priors on ocular anatomy. The edge of the RPE, where the optic disc is located, is then found by traversing the retinal layer containing the RPE, reconstructing local appearance with the low-rank model, and detecting the point at which appearance starts to deviate (i.e., increased reconstruction error). To aid in this detection, we also introduce a geometrical constraint called the distance bias that accounts for the smooth shape of the RPE. Experiments demonstrate that our method outperforms other OCT techniques in localizing the optic disc and estimating disc width. Moreover, we also show the potential usage of our method on optic disc area detection in 3-D OCT volumes. PMID:25438300

  19. Fast localization of optic disc and fovea in retinal images for eye disease screening

    NASA Astrophysics Data System (ADS)

    Yu, H.; Barriga, S.; Agurto, C.; Echegaray, S.; Pattichis, M.; Zamora, G.; Bauman, W.; Soliz, P.

    2011-03-01

    Optic disc (OD) and fovea locations are two important anatomical landmarks in automated analysis of retinal disease in color fundus photographs. This paper presents a new, fast, fully automatic optic disc and fovea localization algorithm developed for diabetic retinopathy (DR) screening. The optic disc localization methodology comprises of two steps. First, the OD location is identified using template matching and directional matched filter. To reduce false positives due to bright areas of pathology, we exploit vessel characteristics inside the optic disc. The location of the fovea is estimated as the point of lowest matched filter response within a search area determined by the optic disc location. Second, optic disc segmentation is performed. Based on the detected optic disc location, a fast hybrid level-set algorithm which combines the region information and edge gradient to drive the curve evolution is used to segment the optic disc boundary. Extensive evaluation was performed on 1200 images (Messidor) composed of 540 images of healthy retinas, 431 images with DR but no risk of macular edema (ME), and 229 images with DR and risk of ME. The OD location methodology obtained 98.3% success rate, while fovea location achieved 95% success rate. The average mean absolute distance (MAD) between the OD segmentation algorithm and "gold standard" is 10.5% of estimated OD radius. Qualitatively, 97% of the images achieved Excellent to Fair performance for OD segmentation. The segmentation algorithm performs well even on blurred images.

  20. Unilateral Acute Anterior Ischemic Optic Neuropathy in a Patient with an Already Established Diagnosis of Bilateral Optic Disc Drusen

    PubMed Central

    Ayhan, Ziya; Yaman, Aylin; Söylev Bajin, Meltem; Saatci, A. Osman

    2015-01-01

    Optic disc drusen (ODD) are calcific deposits that form in the optic nerve head secondary to abnormalities in axonal metabolism and degeneration. Anterior ischemic optic neuropathy, central retinal artery, and vein occlusion are among the rare vascular complications of disc drusen. We reported the clinical course of a 51-year-old patient with a unilateral acute nonarteritic anterior ischemic optic neuropathy (NAION) who received the diagnosis of bilateral optic disc drusen five years earlier and thereby reiterated the association of ODD and acute NAION. PMID:26550507

  1. A study of the causes of bilateral optic disc swelling in Japanese patients

    PubMed Central

    Iijima, Kei; Shimizu, Kimiya; Ichibe, Yoshiaki

    2014-01-01

    Purpose To investigate the etiology of bilateral disc swelling in Japanese. Methods Using Kitasato University’s Department of Neuro-Ophthalmology medical records and fundus photographs of the period December 1977 through November 2010, we retrospectively identified 121 outpatients who had been initially confirmed with bilateral disc swelling. Results The most common cause of the bilateral disc swelling was increased intracranial pressure (ICP) (59%); followed by pseudopapillitis (16%); uveitis (8%); hypertensive retinopathy (5%); bilateral optic neuritis, acute disseminated encephalomyelitis (ADEM) and optic disc drusen (all at 2% each); and leukemia (1%). Unknown etiology accounted for 6% of the cases. Conclusion Although increased ICP is the most common etiology for bilateral disc swelling, it can also be triggered by a variety of other causes. Pseudopapillitis is the most important progenitor of bilateral disc swelling in Japanese. PMID:25031527

  2. The aging mouse partially models the aging human spine: lumbar and coccygeal disc height, composition, mechanical properties, and Wnt signaling in young and old mice

    PubMed Central

    Aguilar, Rhiannon; Harland, Robin A.; Bomar, Bradley A.; Silva, Matthew J.

    2014-01-01

    Murine lumbar and coccygeal (tail) regions of spines are commonly used to study cellular signaling of age-related disc diseases, but the tissue-level changes of aging intervertebral discs and vertebrae of each spinal region remain unclear. Furthermore, the impact of aging lumbar and coccygeal discs on Wnt/?-catenin signaling, which is putatively involved in the catabolism of intervertebral discs, is also unclear. We compared disc/vertebrae morphology and mechanics and biochemical composition of intervertebral discs from lumbar and coccygeal regions between young (4–5 mo) and old (20–22 mo) female C57BL/6 mice. Center intervertebral disc height from both regions was greater in old discs than young discs. Compared with young, old lumbar discs had a lower early viscous coefficient (a measure of stiffness) by 40%, while conversely old coccygeal discs were stiffer by 53%. Biochemically, old mice had double the collagen content in lumbar and coccygeal discs of young discs, greater glycosaminoglycan in lumbar discs by 37%, but less glycosaminoglycan in coccygeal discs by 32%. Next, we compared Wnt activity of lumbar and coccygeal discs of 4- to 5-mo and 12- to 14-mo TOPGAL mice. Despite the disc-specific changes, aging decreased Wnt signaling in the nucleus pulposus from both spinal regions by ?64%. Compared with young, trabecular bone volume/tissue volume and ultimate force were less in old lumbar vertebrae, but greater in old coccygeal vertebrae. Thus intervertebral discs and vertebrae age in a spinal region-dependent manner, but these differential age-related changes may be uncoupled from Wnt signaling. Overall, lumbar and coccygeal regions are not interchangeable in modeling human aging. PMID:24790018

  3. Segmentation of the optic disc in 3-D OCT scans of the optic nerve head.

    PubMed

    Lee, Kyungmoo; Niemeijer, Meindert; Garvin, Mona K; Kwon, Young H; Sonka, Milan; Abramoff, Michael D

    2010-01-01

    Glaucoma is the second leading ocular disease causing blindness due to gradual damage to the optic nerve and resultant visual field loss. Segmentations of the optic disc cup and neuroretinal rim can provide important parameters for detecting and tracking this disease. The purpose of this study is to describe and evaluate a method that can automatically segment the optic disc cup and rim in spectral-domain 3-D OCT (SD-OCT) volumes. Four intraretinal surfaces were segmented using a fast multiscale 3-D graph search algorithm. After surface segmentation, the retina in each 3-D OCT scan was flattened to ensure a consistent optic nerve head shape. A set of 15 features, derived from the segmented intraretinal surfaces and voxel intensities in the SD-OCT volume, were used to train a classifier that can determine which A-scans in the OCT volume belong to the background, optic disc cup and rim. Finally, prior knowledge about the shapes of the cup and rim was incorporated into the system using a convex hull-based approach. Two glaucoma experts annotated the cup and rim area using planimetry, and the annotations of the first expert were used as the reference standard. A leave-one-subject-out experiment on 27 optic nerve head-centered OCT volumes (14 right eye scans and 13 left eye scans from 14 patients) was performed. Two different types of classification methods were compared, and experimental results showed that the best performing method had an unsigned error for the optic disc cup of 2.52+/-0.87 pixels (0.076+/-0.026 mm) and for the neuroretinal rim of 2.04+/-0.86 pixels (0.061+/-0.026 mm). The interobserver variability as indicated by the unsigned border positioning difference between the second expert observer and the reference standard was 2.54+/-1.03 pixels (0.076+/-0.031 mm for the optic disc cup and 2.14+/-0.80 pixels (0.064+/-0.024 mm for the neuroretinal rim. The unsigned error of the best performing method was not significantly different (p > 0.2) from the interobserver variability. PMID:19758857

  4. Estimated Rates of Retinal Ganglion Cell Loss in Glaucomatous Eyes with and without Optic Disc Hemorrhages

    PubMed Central

    Gracitelli, Carolina P. B.; Tatham, Andrew J.; Zangwill, Linda M.; Weinreb, Robert N.; Liu, Ting; Medeiros, Felipe A.

    2014-01-01

    Purpose To evaluate whether optic disc hemorrhages are associated with faster rates of estimated retinal ganglion cell (RGC) loss in glaucoma. Methods A longitudinal observational cohort study of 222 eyes of 122 patients with glaucoma recruited from the Diagnostic Innovations Glaucoma Study (DIGS) followed for an average of 3.74±0.85 years. All subjects had optical coherence tomography and standard automated perimetry during follow up. Optic disc hemorrhages were detected by masked evaluation of stereophotographs. Rates of change in estimated numbers of RGCs were determined using a previously described method. A random coefficients model was used to investigate the relationship between disc hemorrhages and rates of change in estimated RGC counts over time. Results 19 eyes of 18 subjects had at least one disc hemorrhage during follow up. At baseline, average estimated RGC counts in eyes with and without disc hemorrhages were 677,994 cells and 682,021 cells, respectively (P?=?0.929). Eyes with optic disc hemorrhages during follow-up had significantly faster rates of estimated RGC loss than eyes without disc hemorrhages (22,233 cells/year versus 10,704 cells/year, P?=?0.020). The effect of disc hemorrhages on the rates of estimated RGC loss remained significant after adjusting for confounding variables. Conclusion Eyes with disc hemorrhages showed faster rates of RGC loss compared to eyes without disc hemorrhages. These results provide further evidence that disc hemorrhages should be considered as an indicator of increased risk for faster neural loss in glaucoma. PMID:25157619

  5. Retinal imaging tool for assessment of the parapapillary atrophy and the optic disc 

    E-print Network

    Lu, Cheng-Kai

    2012-11-29

    Ophthalmic diseases such as glaucoma are associated with progressive changes in the structure of the optic disc (OD) and parapapillary atrophy (PPA). These structural changes may therefore have relevance to other systemic ...

  6. Inverted autologous internal limiting membrane for management of optic disc pit with macular detachment.

    PubMed

    Mohammed, Osman Abdelzaher; Pai, Anant

    2013-01-01

    Macular detachment causes visual deterioration in 25-75% of patients with congenital optic disc pit. A number of treatment options have been reported to manage the macular detachment in optic pit. An optic disc pit represents a defect in the lamina cribrosa; theoretically, an ideal procedure to treat optic pit associated macular detachment would be one that prevents the flow of fluid across the pit by creating an additional barrier. We present a new surgical technique that employs an autologous internal limiting membrane (ILM) to create this barrier. The technique involves standard vitrectomy along-with ILM peeling. Subsequently, the peeled ILM was inverted and transplanted onto the optic disc pit to close the optic nerve pit. This technique showed satisfactory anatomic result with good functional improvement in visual acuity. PMID:24339690

  7. Residual hydrogen peroxide as a function of platinum disc age.

    PubMed

    Kaplan, E N; Gundel, R E; Sosale, A; Sack, R

    1992-07-01

    Recently there has been considerable attention given to the possible deleterious effects of residual hydrogen peroxide on both the cornea and the crystalline lens of the eye. We measured residual hydrogen peroxide levels of the AOSept disinfection system at regular intervals over a 4 month period. By 1 month the residual hydrogen peroxide level was 21 ppm +/- 9.4 (mean +/- standard deviation); at the end of 2 months it was 36 ppm +/- 17.6. At 3 months, when disc replacement is recommended, the residual hydrogen peroxide level was 43 ppm +/- 4.7 (range: 17-98 ppm). At 4 months the residual hydrogen peroxide level rose to a mean of 48 ppm +/- 18.2. The increase in measured residual hydrogen peroxide between month 1 and each successive month was found to be statistically significant. However, these levels failed to induce an increase in symptomatology or slit lamp findings. As determined by scanning electron microscopy there was an erosion of the platinum coating with time that appeared to coincide with the measured residual peroxide level. Cultures of randomly selected platinum discs at the end of 4 months failed to reveal more than isolated positive findings of Staphylococcus epidermidis. While an increase in residual peroxide with time may lead to greater disinfecting capabilities of this system, the possibility of corneal damage as a direct result of high peroxide levels is of concern. PMID:1499119

  8. On how optical depth tunes the effects of the interstellar medium on debris discs

    NASA Astrophysics Data System (ADS)

    Marzari, F.; Thébault, P.

    2011-09-01

    The flux of neutral atoms of the interstellar medium (ISM) surrounding stars and their environment affects the motion of dust particles in debris discs, causing a significant dynamical evolution. Large values of eccentricity and inclination can be excited, and strong correlations settle in among the orbital angles. This dynamical behaviour, in particular for bound dust grains, can potentially cause significant asymmetries in dusty discs around solar-type stars, which might be detected by observations. However, the amount of orbital change as a result of this non-gravitational perturbation is strongly limited by the collisional lifetime of dust particles. We show that, for large values of the disc's optical depth, the influence of the ISM flow on the disc shape is almost negligible. This is because the grains are collisionally destroyed before they can accumulate enough orbital changes as a result of the ISM perturbations. However, for values smaller than 10-3, peculiar asymmetric patterns appear in the density profile of the disc when we consider grains of 1-10 ?m grains, just above the blow-out threshold. The extent and relevance of these asymmetries grow for lower values of the optical depth. An additional sink mechanism, which might prevent the formation of large clumps and warping in the discs, is related to the fast inward migration as a result of the drag component of the forces. When a significant eccentricity is enlarged by the ISM perturbations, the drag forces (Poynting-Robertson drag and, in particular, ISM drag) drive the disc particles on fast migrating tracks, leading them into the star on a short time-scale. It is then expected that discs with small optical depth expand inside the parent body ring all the way towards the star, while discs with large optical depth would not significantly extend inside.

  9. Associations between Optic Cup-to-disc Ratio and Systemic Factors in the Healthy Korean Population

    PubMed Central

    Kim, Yang Jae; Shim, Seong Hee; Bae, Jeong Hun; Park, Ki Ho

    2015-01-01

    Purpose To assess the relationships between optic cup-to-disc ratio (CDR) and age, sex, and other demographic and health characteristics in the healthy Korean population. Methods The study design was retrospective and population-based. A total of 28,377 subjects who participated in the Korea National Health and Nutrition Examination Survey between 2008 and 2011 were enrolled in this study. Participants underwent structured interviews as well as systemic and ophthalmic examinations. Patients with glaucoma who were diagnosed using the International Society of Geographical and Epidemiological Ophthalmology classification were excluded. Changes in vertical CDR were examined by age in relation to systemic variables on multiple regression analysis. Results The mean vertical CDR was 0.34 ± 0.12. The vertical CDR increased with age from subjects in their 20s to those in their 80s (p < 0.001). The mean CDR in males was significantly higher than that of females (p < 0.001). On multiple regression analysis, the vertical CDR was positively associated with age (p < 0.001), male sex (p < 0.001), diastolic blood pressure (p = 0.009), and intraocular pressure (p < 0.001) but was negatively associated with body mass index (p < 0.001). Conclusions Greater vertical CDR was related to age, male sex, higher diastolic blood pressure, higher intraocular pressure, and lower body mass index in healthy Koreans. PMID:26457040

  10. Measuring the vertical age structure of the Galactic disc using asteroseismology and SAGA

    NASA Astrophysics Data System (ADS)

    Casagrande, L.; Silva Aguirre, V.; Schlesinger, K. J.; Stello, D.; Huber, D.; Serenelli, A. M.; Schönrich, R.; Cassisi, S.; Pietrinferni, A.; Hodgkin, S.; Milone, A. P.; Feltzing, S.; Asplund, M.

    2016-01-01

    The existence of a vertical age gradient in the Milky Way disc has been indirectly known for long. Here, we measure it directly for the first time with seismic ages, using red giants observed by Kepler. We use Strömgren photometry to gauge the selection function of asteroseismic targets, and derive colour and magnitude limits where giants with measured oscillations are representative of the underlying population in the field. Limits in the 2MASS system are also derived. We lay out a method to assess and correct for target selection effects independent of Galaxy models. We find that low-mass, i.e. old red giants dominate at increasing Galactic heights, whereas closer to the Galactic plane they exhibit a wide range of ages and metallicities. Parametrizing this as a vertical gradient returns approximately 4 Gyr kpc-1 for the disc we probe, although with a large dispersion of ages at all heights. The ages of stars show a smooth distribution over the last ?10 Gyr, consistent with a mostly quiescent evolution for the Milky Way disc since a redshift of about 2. We also find a flat age-metallicity relation for disc stars. Finally, we show how to use secondary clump stars to estimate the present-day intrinsic metallicity spread, and suggest using their number count as a new proxy for tracing the ageing of the disc. This work highlights the power of asteroseismology for Galactic studies; however, we also emphasize the need for better constraints on stellar mass-loss, which is a major source of systematic age uncertainties in red giant stars.

  11. Optic Disc and Cup Segmentation from Color Fundus Photograph Using Graph Cut with Priors

    PubMed Central

    Zheng, Yuanjie; Stambolian, Dwight; O’Brien, Joan; Gee, James C.

    2014-01-01

    For automatic segmentation of optic disc and cup from color fundus photograph, we describe a fairly general energy function that can naturally fit into a global optimization framework with graph cut. Distinguished from most previous work, our energy function includes priors on the shape & location of disc & cup, the rim thickness and the geometric interaction of “disc contains cup”. These priors together with the effective optimization of graph cut enable our algorithm to generate reliable and robust solutions. Our approach is able to outperform several state-of-the-art segmentation methods, as shown by a set of experimental comparisons with manual delineations and a series of results of correlations with the assessments of a merchant-provided software from Optical Coherence Tomography (OCT) regarding several cup and disc parameters. PMID:24579126

  12. A new methodology for optical sensing and identification using optical-disc drives

    NASA Astrophysics Data System (ADS)

    Schaefer, Samuel; Chau, Kenneth J.

    2011-08-01

    Optical disc drives are inexpensive, readily available, and use highly sophisticated optoelectronic components which can be adapted for sensing. One limitation of using compact discs (CDs) and optical disk drives for sensing of analytes placed on a CD is the fluctuations in the voltage signal from the disk drive generated while reading the data on the CD. In this study, we develop a simple, low-cost strategy for sensing and identification using CDs and optical disk drives that spectrally separates contributions to the voltage signal caused by an analyte intentionally placed onto the CD and that caused by the underlying data on the CD. Analytes are printed onto a CD surface with fixed spatial periodicity. As the laser beam in an optical disk drive scans over the section of the CD containing the analyte pattern, the intensity of the laser beam incident onto the photodiode integrated into the disk drive is modulated at a frequency dependent on the spatial periodicity of the analyte pattern and the speed of the optical disk drive motor. Fourier transformation of the voltage signal from the optical disk drive yields peaks in the frequency spectrum with amplitudes and locations that enable analyte sensing and identification, respectively. We study the influence of analyte area coverage, pattern periodicity, and CD rotational frequency on the peaks in the frequency spectrum associated with the patterned analyte. We apply this technique to discriminate differently-coloured analytes, perform trigger-free detection of multiple analytes distributed on a single CD, and detect at least two different, overlapped analyte patterns on a single CD. The extension of this technique for sensing and identification of colorimetric chemical reagents is discussed. Future work will focus on adapting this technique to perform measurements at multiple wavelengths and streamlining the data collection and processing.

  13. Agreement of glaucoma specialists and experienced optometrists in gonioscopy and optic disc evaluation

    PubMed Central

    Kumar, Addepalli U.; Jonnadula, Ganesh B.; Garudadri, Chandrasekhar; Rao, Harsha L.; Senthil, Sirisha; Papas, Eric B.; Sankaridurg, Padmaja; Khanna, Rohit C.

    2013-01-01

    Purpose To compare the diagnostic performance of glaucoma specialists and experienced optometrists in gonioscopy and optic disc assessment. Methods This study was done to validate the diagnostic performance of two experienced optometrists for using their skills of detecting glaucoma using gonioscopy and optic disc assessment in a major epidemiological study, the L V Prasad Eye Institute Glaucoma Epidemiology and Molecular Genetics Study (LVPEI-GLEAMS). Gonioscopic findings for 150 eyes were categorized as 0, 1 and 2 for open angle, primary angle closure suspect (PACS) and primary angle closure (PAC) respectively. Optic disc findings for 200 eyes were categorized as 0, 1 and 2 for normal, suspects and glaucomatous respectively. Weighted kappa (?) and diagnostic accuracy parameters were calculated. Two optometrists (#1 and #2) participated in the study. Results Agreement between glaucoma specialists and optometrist for interpretation of gonioscopy to discriminate PACS and PAC from open angles and for interpretation of optic disc to discriminate glaucomatous and suspicious discs from normal, the kappa (?) was 0.92 and 0.84 and 0.90 and 0.89 for optometrists #1 and #2 respectively. Sensitivities and specificities were above 90% for gonioscopy. Optic disc evaluation had specificities greater than 95% to discriminate normal from glaucomatous discs while the sensitivities were 83% and 93% for optometrists #1 and #2 respectively. Conclusion Agreement between optometrists and glaucoma specialists, in diagnostic performance of gonioscopy and optic assessment was excellent with high sensitivity and specificity. Hence, we conclude that the experienced optometrists can detect glaucoma accurately in the LVPEI-GLEAMS.

  14. Teaching of optics in the optics age

    NASA Astrophysics Data System (ADS)

    Parasnis, A. S.

    1995-10-01

    The present Optics Age of science had not been foreseen by curriculum- makers in many countries. The result is that during the last 25 years when activity in science, engineering, technology and industry related to optics and lasers was exploding in the advanced countries optics was being de-emphasized in curricula in these countries. The consequence is that these countries including India have not played good enough a role. It is shown that the changes needed are more in attitude, pedagogic tools, terminology, and teaching methodology than in curricular contents. Examples: (1) The sequence of topics be changed, (2) The concept of coherence be introduced by considering thought experiments with different light sources; it is shown that the Michelson interferometer along with an HeNe laser can be used to introduce spatial as well as temporal coherence, (3) Modern terminology be used, (4) Crystal optics which is difficult be divorced from the concept of polarization which is simple; greater attention be paid to polarization helix than to polarization ellipse so that the confusion in 'handedness' is eliminated, (5) Group velocity be introduced as related to stationary phase approximation, (6) Modern terms like irradiance, temporal, spatial, frequency spectrum, spatial frequency, etc be used extensively, and so on.

  15. Optic Disc Segmentation by Balloon Snake with Texture from Color Fundus Image

    PubMed Central

    Sun, Jinyang; Luan, Fangjun; Wu, Hanhui

    2015-01-01

    A well-established method for diagnosis of glaucoma is the examination of the optic nerve head based on fundus image as glaucomatous patients tend to have larger cup-to-disc ratios. The difficulty of optic segmentation is due to the fuzzy boundaries and peripapillary atrophy (PPA). In this paper a novel method for optic nerve head segmentation is proposed. It uses template matching to find the region of interest (ROI). The method of vessel erasing in the ROI is based on PDE inpainting which will make the boundary smoother. A novel optic disc segmentation approach using image texture is explored in this paper. A cluster method based on image texture is employed before the optic disc segmentation step to remove the edge noise such as cup boundary and vessels. We replace image force in the snake with image texture and the initial contour of the balloon snake is inside the optic disc to avoid the PPA. The experimental results show the superior performance of the proposed method when compared to some traditional segmentation approaches. An average segmentation dice coefficient of 94% has been obtained. PMID:25861249

  16. Automated localisation of the optic disc, fovea, and retinal blood vessels from digital colour fundus images

    PubMed Central

    Sinthanayothin, C.; Boyce, J.; Cook, H.; Williamson, T.

    1999-01-01

    AIM—To recognise automatically the main components of the fundus on digital colour images.?METHODS—The main features of a fundus retinal image were defined as the optic disc, fovea, and blood vessels. Methods are described for their automatic recognition and location. 112 retinal images were preprocessed via adaptive, local, contrast enhancement. The optic discs were located by identifying the area with the highest variation in intensity of adjacent pixels. Blood vessels were identified by means of a multilayer perceptron neural net, for which the inputs were derived from a principal component analysis (PCA) of the image and edge detection of the first component of PCA. The foveas were identified using matching correlation together with characteristics typical of a fovea—for example, darkest area in the neighbourhood of the optic disc. The main components of the image were identified by an experienced ophthalmologist for comparison with computerised methods.?RESULTS—The sensitivity and specificity of the recognition of each retinal main component was as follows: 99.1% and 99.1% for the optic disc; 83.3% and 91.0% for blood vessels; 80.4% and 99.1% for the fovea.?CONCLUSIONS—In this study the optic disc, blood vessels, and fovea were accurately detected. The identification of the normal components of the retinal image will aid the future detection of diseases in these regions. In diabetic retinopathy, for example, an image could be analysed for retinopathy with reference to sight threatening complications such as disc neovascularisation, vascular changes, or foveal exudation.?? PMID:10413690

  17. Retinoschisis and macular detachment associated with acquired enlarged optic disc cup.

    PubMed

    Moreno-López, María; González-López, Julio José; Jarrín, Elena; Bertrand, Josefina

    2012-01-01

    We describe a case of maculopathy consisting of macular retinoschisis and serous macular detachment occurring in a patient with an acquired enlarged optic disc cup, similar to the maculopathy observed in congenital optic nerve abnormalities, mainly optic nerve pits and colobomas, without vitreomacular traction nor angiographic leak. Pars plana vitrectomy with argon laser endophotocoagulation and gas tamponade was found to be useful. Traction from membranes covering deep optic disc cups may create small retinal dehiscences, as described in congenital optic nerve abnormalities, which will enable the liquefied vitreous to pass, leading to retinoschisis with or without associated neurosensory detachment. Vitrectomy, photocoagulation, and gas tamponade may be a useful therapy for this entity. PMID:22536032

  18. Optical effects related to Keplerian discs orbiting Kehagias-Sfetsos naked singularities

    NASA Astrophysics Data System (ADS)

    Stuchlík, Zden?k; Schee, Jan

    2014-10-01

    We demonstrate possible optical signatures of the Kehagias-Sfetsos (KS) naked singularity spacetimes representing a spherically symmetric vacuum solution of the modified Ho?ava gravity. In such spacetimes, accretion structures significantly different from those present in standard black hole spacetimes occur due to the ‘antigravity’ effect, which causes an internal static sphere surrounded by Keplerian discs. We focus our attention on the optical effects related to the Keplerian accretion discs, constructing the optical appearance of the Keplerian discs, the spectral continuum due to their thermal radiation, and the spectral profiled lines generated in the innermost parts of such discs. The KS naked singularity signature is strongly encoded in the characteristics of predicted optical effects, especially in cases where the spectral continuum and spectral lines are profiled by the strong gravity of the spacetimes due to the vanishing region of the angular velocity gradient influencing the effectiveness of the viscosity mechanism. We can conclude that optical signatures of KS naked singularities can be well distinguished from the signatures of standard black holes.

  19. Choosing an Optical Disc System: A Guide for Users and Resellers.

    ERIC Educational Resources Information Center

    Vane-Tempest, Stewart

    1995-01-01

    Presents a guide for selecting an optional disc system. Highlights include storage hierarchy; standards; data life cycles; security; implementing an optical jukebox system; optimizing the system; performance; quality and reliability; software; cost of online versus near-line; and growing opportunities. Sidebars provide additional information on…

  20. Case Report of Optic Disc Drusen with Simultaneous Peripapillary Subretinal Hemorrhage and Central Retinal Vein Occlusion

    PubMed Central

    Law, David Zhiwei; Yang, Francine Pei Lin; Teoh, Stephen Charn Beng

    2014-01-01

    A 52-year-old Chinese gentleman presented with right eye floaters and photopsia over one week. His visual acuities were 20/20 bilaterally. Posterior segment examination showed a right eye swollen optic disc and central retinal vein occlusion (CRVO) associated with an area of subretinal hemorrhage adjacent to the optic disc. Fundus fluorescein (FA) and indocyanine green angiographies (ICGA) of the right eye did not demonstrate choroidal neovascularization (CNV), polypoidal choroidal vasculopathy (PCV), or retinal ischemia. Ultrasound B-scan revealed optic disc drusen (ODD). In view of good vision and absence of CNV, he was managed conservatively with spontaneous resolution after two months. Commonly, ODD may directly compress and mechanically rupture subretinal vessels at the optic disc, resulting in peripapillary subretinal hemorrhage, as was likely the case in our patient. Mechanical impairment of peripapillary circulation also results in retinal ischemia and may trigger the development of choroidal neovascularization (CNV) and/or polypoidal choroidal vasculopathy (PCV), leading to subretinal haemorrhage. Compromise in central venous outflow with increased retinal central venous pressure from the direct mechanical effects of enlarging ODD results in central retinal vein occlusion (CRVO). Patients with subretinal hemorrhage and CRVO from ODD should be monitored closely for the development of potentially sight-threatening complications. PMID:25544921

  1. Unifying disc-jet behaviour in X-ray binaries: an optical/IR approach

    E-print Network

    David M. Russell; Dipankar Maitra; Rob P. Fender; Fraser Lewis

    2008-11-18

    Synchrotron emission from jets produced by X-ray binaries can be detected at optical and infrared (IR) frequencies. I show that optical/IR colour-magnitude diagrams of the outbursts of nine X-ray binaries successfully separate thermal disc emission from non-thermal jet emission, in both black hole and neutron star sources. A heated single-temperature blackbody is able to reproduce the observed relations between colour and magnitude, except when excursions are made to a redder colour than expected, which is due to jet emission. The general picture that is developed is then incorporated into the unified picture of disc-jet behaviour in black hole X-ray binaries. At a given position of a source in the X-ray hardness-intensity diagram, the radio, IR and optical properties can be inferred. Similarly, it is possible to predict the X-ray and radio luminosities and spectral states from optical/IR monitoring.

  2. Constraints on the temperature inhomogeneity in quasar accretion discs from the ultraviolet-optical spectral variability

    E-print Network

    Kokubo, Mitsuru

    2015-01-01

    The physical mechanisms of the quasar ultraviolet (UV)-optical variability are not well understood despite the long history of observations. Recently, Dexter & Agol presented a model of quasar UV-optical variability, which assumes large local temperature fluctuations in the quasar accretion discs. This inhomogeneous accretion disc model is claimed to describe not only the single-band variability amplitude, but also microlensing size constraints and the quasar composite spectral shape. In this work, we examine the validity of the inhomogeneous accretion disc model in the light of quasar UV-optical spectral variability by using five-band multi-epoch light curves for nearly 9 000 quasars in the Sloan Digital Sky Survey (SDSS) Stripe 82 region. By comparing the values of the intrinsic scatter $\\sigma_{\\text{int}}$ of the two-band magnitude-magnitude plots for the SDSS quasar light curves and for the simulated light curves, we show that Dexter & Agol's inhomogeneous accretion disc model cannot explain the ...

  3. Measuring the vertical age structure of the Galactic disc using asteroseismology and SAGA

    E-print Network

    Casagrande, L; Schlesinger, K J; Stello, D; Huber, D; Serenelli, A M; Schoenrich, R; Cassisi, S; Pietrinferni, A; Hodgkin, S; Milone, A P; Feltzing, S; Asplund, M

    2015-01-01

    The existence of a vertical age gradient in the Milky Way disc has been indirectly known for long. Here, we measure it directly for the first time with seismic ages, using red giants observed by Kepler. We use Stroemgren photometry to gauge the selection function of asteroseismic targets, and derive colour and magnitude limits where giants with measured oscillations are representative of the underlying population in the field. Limits in the 2MASS system are also derived. We lay out a method to assess and correct for target selection effects independent of Galaxy models. We find that low mass, i.e. old red giants dominate at increasing Galactic heights, whereas closer to the Galactic plane they exhibit a wide range of ages and metallicities. Parametrizing this as a vertical gradient returns approximately 4 Gyr/kpc for the disc we probe, although with a large dispersion of ages at all heights. The ages of stars show a smooth distribution over the last 10 Gyr, consistent with a mostly quiescent evolution for the...

  4. Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration

    PubMed Central

    Vo, Nam V.; Hartman, Robert A.; Yurube, Takashi; Jacobs, Lloydine J.; Sowa, Gwendolyn A.; Kang, James D.

    2013-01-01

    BACKGROUND CONTEXT Destruction of extracellular matrix (ECM) leads to intervertebral disc degeneration (IDD), which underlies many spine-related disorders. Matrix metalloproteinases (MMPs), and disintegrins and metalloproteinases with thrombospondin motifs (ADAMTSs) are believed to be the major proteolytic enzymes responsible for ECM degradation in the intervertebral disc (IVD). PURPOSE To summarize the current literature on gene expression and regulation of MMPs, ADAMTSs, and tissue inhibitors of metalloproteinases (TIMPs) in IVD aging and IDD. METHODS A comprehensive literature review of gene expression of MMP, ADAMTS, and TIMP in human IDD and reported studies on regulatory factors controlling their expressions and activities in both human and animal model systems. RESULTS Upregulation of specific MMPs (MMP-1, -2, -3, -7, -8, -10, and -13) and ADAMTS (ADAMTS-1, -4, and -15) were reported in human degenerated IVDs. However, it is still unclear from conflicting published studies whether the expression of ADAMTS-5, the predominant aggrecanase, is increased with IDD. Tissue inhibitors of metalloproteinase-3 is downregulated, whereas TIMP-1 is upregulated in human degenerated IVDs relative to nondegenerated IVDs. Numerous studies indicate that the expression levels of MMP and ADAMTS are modulated by a combination of many factors, including mechanical, inflammatory, and oxidative stress, some of which are mediated in part through the p38 mitogen-activated protein kinase pathway. Genetic predisposition also plays an important role in determining gene expression of MMP-1, -2, -3, and -9. CONCLUSIONS Upregulation of MMP and ADAMTS expression and enzymatic activity is implicated in disc ECM destruction, leading to the development of IDD. Future IDD therapeutics depends on identifying specific MMPs and ADAMTSs whose dysregulation result in pathological proteolysis of disc ECM. PMID:23369495

  5. Automated segmentation of optic disc in SD-OCT images and cup-to-disc ratios quantification by patch searching-based neural canal opening detection.

    PubMed

    Wu, Menglin; Leng, Theodore; de Sisternes, Luis; Rubin, Daniel L; Chen, Qiang

    2015-11-30

    Glaucoma is one of the most common causes of blindness worldwide. Early detection of glaucoma is traditionally based on assessment of the cup-to-disc (C/D) ratio, an important indicator of structural changes to the optic nerve head. Here, we present an automated optic disc segmentation algorithm in 3-D spectral domain optical coherence tomography (SD-OCT) volumes to quantify this ratio. The proposed algorithm utilizes a two-stage strategy. First, it detects the neural canal opening (NCO) by finding the points with maximum curvature on the retinal pigment epithelium (RPE) boundary with a spatial correlation smoothness constraint on consecutive B-scans, and it approximately locates the coarse disc margin in the projection image using convex hull fitting. Then, a patch searching procedure using a probabilistic support vector machine (SVM) classifier finds the most likely patch with the NCO in its center in order to refine the segmentation result. Thus, a reference plane can be determined to calculate the C/D radio. Experimental results on 42 SD-OCT volumes from 17 glaucoma patients demonstrate that the proposed algorithm can achieve high segmentation accuracy and a low C/D ratio evaluation error. The unsigned border error for optic disc segmentation and the evaluation error for C/D ratio comparing with manual segmentation are 2.216 ± 1.406 pixels (0.067 ± 0.042 mm) and 0.045 ± 0.033, respectively. PMID:26698750

  6. Method and system for assigning a confidence metric for automated determination of optic disc location

    DOEpatents

    Karnowski, Thomas P. (Knoxville, TN); Tobin, Jr., Kenneth W. (Harriman, TN); Muthusamy Govindasamy, Vijaya Priya (Knoxville, TN); Chaum, Edward (Memphis, TN)

    2012-07-10

    A method for assigning a confidence metric for automated determination of optic disc location that includes analyzing a retinal image and determining at least two sets of coordinates locating an optic disc in the retinal image. The sets of coordinates can be determined using first and second image analysis techniques that are different from one another. An accuracy parameter can be calculated and compared to a primary risk cut-off value. A high confidence level can be assigned to the retinal image if the accuracy parameter is less than the primary risk cut-off value and a low confidence level can be assigned to the retinal image if the accuracy parameter is greater than the primary risk cut-off value. The primary risk cut-off value being selected to represent an acceptable risk of misdiagnosis of a disease having retinal manifestations by the automated technique.

  7. Multimodal segmentation of optic disc and cup from stereo fundus and SD-OCT images

    NASA Astrophysics Data System (ADS)

    Miri, Mohammad Saleh; Lee, Kyungmoo; Niemeijer, Meindert; Abràmoff, Michael D.; Kwon, Young H.; Garvin, Mona K.

    2013-03-01

    Glaucoma is one of the major causes of blindness worldwide. One important structural parameter for the diagnosis and management of glaucoma is the cup-to-disc ratio (CDR), which tends to become larger as glaucoma progresses. While approaches exist for segmenting the optic disc and cup within fundus photographs, and more recently, within spectral-domain optical coherence tomography (SD-OCT) volumes, no approaches have been reported for the simultaneous segmentation of these structures within both modalities combined. In this work, a multimodal pixel-classification approach for the segmentation of the optic disc and cup within fundus photographs and SD-OCT volumes is presented. In particular, after segmentation of other important structures (such as the retinal layers and retinal blood vessels) and fundus-to-SD-OCT image registration, features are extracted from both modalities and a k-nearest-neighbor classification approach is used to classify each pixel as cup, rim, or background. The approach is evaluated on 70 multimodal image pairs from 35 subjects in a leave-10%-out fashion (by subject). A significant improvement in classification accuracy is obtained using the multimodal approach over that obtained from the corresponding unimodal approach (97.8% versus 95.2%; p < 0:05; paired t-test).

  8. Quantitative chemical tagging, stellar ages and the chemo-dynamical evolution of the Galactic disc

    NASA Astrophysics Data System (ADS)

    Mitschang, A. W.; De Silva, G.; Zucker, D. B.; Anguiano, B.; Bensby, T.; Feltzing, S.

    2014-03-01

    The early science results from the new generation of high-resolution stellar spectroscopic surveys, such as Galactic Archaeology with HERMES (GALAH) and the Gaia European Southern Observatory survey (Gaia-ESO), will represent major milestones in the quest to chemically tag the Galaxy. Yet this technique to reconstruct dispersed coeval stellar groups has remained largely untested until recently. We build on previous work that developed an empirical chemical tagging probability function, which describes the likelihood that two field stars are conatal, that is, they were formed in the same cluster environment. In this work, we perform the first ever blind chemical tagging experiment, i.e. tagging stars with no known or otherwise discernible associations, on a sample of 714 disc field stars with a number of high-quality high-resolution homogeneous metal abundance measurements. We present evidence that chemical tagging of field stars does identify coeval groups of stars, yet these groups may not represent distinct formation sites, e.g. as in dissolved open clusters, as previously thought. Our results point to several important conclusions, among them that group finding will be limited strictly to chemical abundance space, e.g. stellar ages, kinematics, colours, temperature and surface gravity do not enhance the detectability of groups. We also demonstrate that in addition to its role in probing the chemical enrichment and kinematic history of the Galactic disc, chemical tagging represents a powerful new stellar age determination technique.

  9. Bilateral optic disc pit with maculopathy in a patient with cleft lip and cleft palate

    PubMed Central

    Seth, Anisha; Gupta, Rajat; Gupta, Anika; Raina, Usha K; Ghosh, Basudeb

    2015-01-01

    Optic disc pit (ODP) is small, gray-white, oval depression found at the optic nerve head. It is a congenital defect that occurs due to imperfect closure of superior edge of the embryonic fissure. Cleft lip and palate are also congenital midline abnormalities occurring due to defect in the fusion of frontonasal prominence, maxillary prominence and mandibular prominence. There is only one case report describing the occurrence of ODP in a young patient with cleft lip and palate who also had basal encephalocele. We describe a 52-year-old patient with congenital cleft lip and palate with bilateral ODP with maculopathy but without any other midline abnormality. PMID:26044478

  10. New optical architecture for holographic data storage system compatible with Blu-ray Disc™ system

    NASA Astrophysics Data System (ADS)

    Shimada, Ken-ichi; Ide, Tatsuro; Shimano, Takeshi; Anderson, Ken; Curtis, Kevin

    2014-02-01

    A new optical architecture for holographic data storage system which is compatible with a Blu-ray Disc™ (BD) system is proposed. In the architecture, both signal and reference beams pass through a single objective lens with numerical aperture (NA) 0.85 for realizing angularly multiplexed recording. The geometry of the architecture brings a high affinity with an optical architecture in the BD system because the objective lens can be placed parallel to a holographic medium. Through the comparison of experimental results with theory, the validity of the optical architecture was verified and demonstrated that the conventional objective lens motion technique in the BD system is available for angularly multiplexed recording. The test-bed composed of a blue laser system and an objective lens of the NA 0.85 was designed. The feasibility of its compatibility with BD is examined through the designed test-bed.

  11. Behaviour of Disc Oedema During and After Amiodarone Optic Neuropathy: Case Report

    PubMed Central

    Martínez-Gamero, Bertha O.; Mohamed-Noriega, Jibran; Cavazos-Adame, Med. Humberto; Mohamed-Hamsho, Med. Jesús

    2014-01-01

    A 73-year-old woman with atrial fibrillation treated with Amiodarone presented with Optic Disc oedema in right eye (OD). Using Optical Coherence Tomography (OCT) we describe the impact of this neuropathy on Retinal Nerve Fibre Layer (RNFL). At diagnosis RNFL average was of 188 ?m OD and 77 ?m in the left eye (OS), six months after discontinuation of the drug decreased to 40 ?m in OD and 76 ?m in OS. The RNFL average of OD presented a transient increase during the acute oedema that returned to normal levels during the first month after discontinuation of the drug and fell dramatically to 44 ?m at the second month and 40 ?m at the sixth month. We show there is axonal loss after amiodarone-associated optic neuropathy measured with OCT. The OCT may be used in these patients to document changes in RNFL in the follow-up. PMID:24959500

  12. Papilledema and optic disc pit: The association of two pathologies in one patient.

    PubMed

    Galvez-Ruiz, Alberto; Ghazi, Nicola; Ruhaily, Yasir

    2012-10-01

    Histologically, optic disc pit (ODP) is described as a small congenital defect in the cribriform plate where a herniation of the dysplastic retina extends to the subarachnoid space in the optic nerve, which is surrounded by a layer of collagen-rich tissue. Approximately 25-75% of cases are complicated by optic disc pit maculopathy (ODPM). The pathogenesis of maculopathies associated with ODP has not been fully elucidated. We present an unusual case of a patient with a history of papilledema secondary to a fronto-temporal meningioma. The patient underwent a successful surgical intervention with resolution of the papilledema 15 years before the detection of an ODP that was associated with retinal detachment in the macular region. Several studies have reported on the importance of intracranial pressure in the development of maculopathies associated with ODP. During the period of intracranial hypertension and papilledema in our patient, the hernia sac that was associated with ODP may have been small, which would have decreased the chances of developing a maculopathy that was associated with OPD. PMID:23961031

  13. Factors Affecting Cirrus-HD OCT Optic Disc Scan Quality: A Review with Case Examples

    PubMed Central

    Hardin, Joshua S.; Taibbi, Giovanni; Nelson, Seth C.; Chao, Diana; Vizzeri, Gianmarco

    2015-01-01

    Spectral-domain OCT is an established tool to assist clinicians in detecting glaucoma and monitor disease progression. The widespread use of this imaging modality is due, at least in part, to continuous hardware and software advancements. However, recent evidence indicates that OCT scan artifacts are frequently encountered in clinical practice. Poor image quality invariably challenges the interpretation of test results, with potential implications for the care of glaucoma patients. Therefore, adequate knowledge of various imaging artifacts is necessary. In this work, we describe several factors affecting Cirrus HD-OCT optic disc scan quality and their effects on measurement variability. PMID:26351574

  14. Optical Spectroscopic Monitoring of Parachute Yarn Aging

    SciTech Connect

    Tallant, D.R.; Garcia, M.J.; Simpson, R.L.; Behr, V.L.; Whinery, L.D.; Peng, L.W.

    1999-04-01

    Optical spectroscopic techniques were evaluated as nondestructive monitors of the aging of parachutes in nuclear weapons. We analyzed thermally aged samples of nylon and Kevlar webbing by photoluminescence spectroscopy and reflection spectroscopy. Infrared analysis was also performed to help understand the degradation mechanisms of the polymer materials in the webbing. The photoluminescence and reflection spectra were analyzed by chemometric data treatment techniques to see if aged-induced changes in the spectra correlated to changes in measured tensile strength. A correlation was found between the shapes of the photoluminescent bands and the measured tensile strengths. Photoluminescent spectra can be used to predict the tensile strengths of nylon and Kevlar webbing with sufficient accuracy to categorize the webbing sample as above rated tensile strength, marginal or below rated tensile strength. The instrumentation required to perform the optical spectroscopic measurement can be made rugged, compact and portable. Thus, optical spectroscopic techniques offer a means for nondestructive field monitoring of parachutes in the enduring stockpile/

  15. Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology.

    PubMed

    Springelkamp, Henriët; Mishra, Aniket; Hysi, Pirro G; Gharahkhani, Puya; Höhn, René; Khor, Chiea-Chuen; Cooke Bailey, Jessica N; Luo, Xiaoyan; Ramdas, Wishal D; Vithana, Eranga; Koh, Victor; Yazar, Seyhan; Xu, Liang; Forward, Hannah; Kearns, Lisa S; Amin, Najaf; Iglesias, Adriana I; Sim, Kar-Seng; van Leeuwen, Elisabeth M; Demirkan, Ayse; van der Lee, Sven; Loon, Seng-Chee; Rivadeneira, Fernando; Nag, Abhishek; Sanfilippo, Paul G; Schillert, Arne; de Jong, Paulus T V M; Oostra, Ben A; Uitterlinden, André G; Hofman, Albert; Zhou, Tiger; Burdon, Kathryn P; Spector, Timothy D; Lackner, Karl J; Saw, Seang-Mei; Vingerling, Johannes R; Teo, Yik-Ying; Pasquale, Louis R; Wolfs, Roger C W; Lemij, Hans G; Tai, E-Shyong; Jonas, Jost B; Cheng, Ching-Yu; Aung, Tin; Jansonius, Nomdo M; Klaver, Caroline C W; Craig, Jamie E; Young, Terri L; Haines, Jonathan L; MacGregor, Stuart; Mackey, David A; Pfeiffer, Norbert; Wong, Tien-Yin; Wiggs, Janey L; Hewitt, Alex W; van Duijn, Cornelia M; Hammond, Christopher J

    2015-03-01

    Primary open-angle glaucoma is the most common optic neuropathy and an important cause of irreversible blindness worldwide. The optic nerve head or optic disc is divided in two parts: a central cup (without nerve fibers) surrounded by the neuroretinal rim (containing axons of the retinal ganglion cells). The International Glaucoma Genetics Consortium conducted a meta-analysis of genome-wide association studies consisting of 17,248 individuals of European ancestry and 6,841 individuals of Asian ancestry. The outcomes of the genome-wide association studies were disc area and cup area. These specific measurements describe optic nerve morphology in another way than the vertical cup-disc ratio, which is a clinically used measurement, and may shed light on new glaucoma mechanisms. We identified 10 new loci associated with disc area (CDC42BPA, F5, DIRC3, RARB, ABI3BP, DCAF4L2, ELP4, TMTC2, NR2F2, and HORMAD2) and another 10 new loci associated with cup area (DHRS3, TRIB2, EFEMP1, FLNB, FAM101, DDHD1, ASB7, KPNB1, BCAS3, and TRIOBP). The new genes participate in a number of pathways and future work is likely to identify more functions related to the pathogenesis of glaucoma. PMID:25631615

  16. Optical methods for diagnostics and feedback control in laser-induced regeneration of spine disc and joint cartilages

    NASA Astrophysics Data System (ADS)

    Sobol, Emil; Sviridov, Alexander; Omeltchenko, Alexander; Baum, Olga; Baskov, Andrey; Borchshenko, Igor; Golubev, Vladimir; Baskov, Vladimir

    2011-03-01

    In 1999 we have introduced a new approach for treatment of spine diseases based on the mechanical effect of nondestructive laser radiation on the nucleus pulposus of the intervertebral disc. Laser reconstruction of spine discs (LRD) involves puncture of the disc and non-destructive laser irradiation of the nucleus pulposus to activate reparative processes in the disc tissues. In vivo animal study has shown that LRD allows activate the growth of hyaline type cartilage in laser affected zone. The paper considers physical processes and mechanisms of laser regeneration, presents results of investigations aimed to optimize laser settings and to develop feedback control system for laser reparation in cartilages of spine and joints. The results of laser reconstruction of intervertebral discs for 510 patients have shown substantial relief of back pain for 90% of patients. Laser technology has been experimentally tested for reparation of traumatic and degenerative diseases in joint cartilage of 20 minipigs. It is shown that laser regeneration of cartilage allows feeling large (more than 5 mm) defects which usually never repair on one's own. Optical techniques have been used to promote safety and efficacy of the laser procedures.

  17. Structural and optical properties of disc-in-wire InGaN/GaN LEDs.

    PubMed

    Yan, Lifan; Jahangir, Shafat; Wight, Scott A; Nikoobakht, Babak; Bhattacharya, Pallab; Millunchick, Joanna M

    2015-03-11

    This study examines the role of the microstructure and optical properties of InGaN/GaN nanowire LED structures on Si(111) having different nanowire coverages. Cathodoluminescence (CL) measurements show that all samples exhibit broad emission around the intended energy, 1.95 eV (635 nm). While the absolute emission intensity is hard to compare for CL measurement, the bandgap emission (?3.4 eV) coming from the GaN root is more pronounced as coverage of nanowires decreases, which has less coalescence formation. The width of the emission peak is likely due to variations in the morphology of the InGaN discs within the wires, as faceted layers with different thicknesses and quantum dots are observed by transmission electron microscopy. Nonepitaxial six-fold symmetric lateral branching, called "nanocrowns," emanate from stacking faults within the active regions. These features likely reduce optical emission as a result of grain boundaries between the nanocrown and nanowire. PMID:25658444

  18. Association of retinal thickness and optic disc-to-fovea angle to axial length of young healthy eyes

    PubMed Central

    Yamashita, Takehiro; Sakamoto, Taiji; Terasaki, Hiroto; Tanaka, Minoru; Kii, Yuya; Uchino, Eisuke; Hisatomi, Toshio; Nakao, Kumiko

    2015-01-01

    Aim To determine the relationship between the axial length (AL) and the retinal thickness in the posterior pole and to the optic disc-to-fovea (ODF) angle of healthy eyes. Procedures A prospective, observational cross-sectional study (registration number, UMIN000006040) of 64 healthy right eyes (mean age 26.0±4.5 years) was performed. The thickness of the 64 areas within the central 24° area were measured in the Spectralis spectral domain–optical coherent tomographic images obtained by posterior pole scans. Each area was 3°×3°. The ODF angle was measured in each fundus photograph. The relationships between the AL and the retinal thickness of each of the 64 areas and the ODF angle were investigated by linear regression analyses. Results The mean AL was 25.0±1.3 mm and the mean ODF angle was 17.2°±1.0°. The average retinal thickness of the four areas around the fovea was constant and not significantly correlated with the AL. However, the retinal thicknesses of 54 of the other 60 areas were significantly and negatively correlated with the AL (R=?0.25 to ?0.56, P<0.05). The ODF angle was also constant and not significantly correlated with the AL (R=?0.17, P=0.19). Conclusion The lack of significant correlations between the AL and the retinal thicknesses of the central 6° or the ODF angle suggests that there might be some feedback system to keep the central retinal thickness and ODF angle constant regardless of an elongation of the AL. PMID:26664037

  19. Macular and optic disc edema and retinal vascular leakage in familial amyloid polyneuropathy with a transthyretin Val30Met mutation: a case report

    PubMed Central

    2014-01-01

    Introduction Familial amyloid polyneuropathy is a group of autosomal dominant disorders characterized by extracellular amyloid deposition in several target organs. This paper aims to report an unusual manifestation of retinal vascular leakage including optic disc and macular edema in a patient with familial amyloid polyneuropathy. Case presentation A 37-year-old Portuguese Caucasian man with Val30Met transthyretin-related familial amyloid polyneuropathy presented with rapidly progressing visual loss in his left eye. He had undergone liver transplantation at the age of 30 with neurologic stabilization. Fundoscopy and fluorescein angiogram revealed optic disc and macular edema as well as vessel wall staining with leakage in the posterior pole and mid-periphery, without vitreous opacities. A diagnostic work-up for infectious, autoimmune and neoplasic conditions was negative. Systemic immunosuppression was increased but without improvement. Sustained resolution of macular edema was observed after intravitreal injection of dexamethasone implant and laser panretinal photocoagulation. Conclusions To the best of our knowledge, this is the first report of a rare ocular manifestation of familial amyloid polyneuropathy which represents a new therapeutic challenge. Intravitreal injection of sustained release dexamethasone implant and panretinal photocoagulation may be an effective eye-saving therapeutic approach. PMID:25282612

  20. Autologous platelet concentrate in surgery for macular detachment associated with congenital optic disc pit

    PubMed Central

    Nadal, Jeroni; Figueroa, Marta S; Carreras, Elisa; Pujol, Patricia; Canut, Maria Isabel; Barraquer, Rafael Ignacio

    2015-01-01

    Purpose To evaluate the anatomical and functional results obtained with pars plana vitrectomy (PPV) plus autologous platelet concentrate (APC) as a treatment for macular detachment associated with optic disc pit (ODP). Methods We performed a prospective interventional study of 19 eyes of 19 consecutive patients with posterior macular detachment due to ODP. All patients underwent PPV, posterior hyaloid peeling, fluid–air exchange, injection of 0.05 mL of APC over the ODP and 15% perfluoropropane (C3F8) endotamponade. Postoperative measures included face-up positioning for 2 hours and then avoidance of the face-up position during the ensuing 10 days. All patients underwent complete ophthalmologic examination and optical coherence tomography preoperatively at 1 month, 3 months, 6 months, 9 months, and 12 months postoperatively and then annually. Outcome measures were best corrected visual acuity (BCVA) by logMAR, improvement of quality of vision, macular attachment, and resolution of intraretinal schisis-like separation. Results Preoperatively, the median BCVA was 0.70 (range: 0.30–1.70) and all patients showed improved visual acuity after surgery; BCVA was 0.22 (range: 0.07–0.52) at 12 months follow-up. All patients showed complete reabsorption of intraretinal fluid (median time: 3.5 months [range: 2–8 months]) and macular attachment at the end of follow-up (median: 60 months [range: 12–144 months]), with stable or improved visual acuity. No reoperations were needed and no major adverse events were recorded. Conclusion For macular detachment associated with ODP, the combination of PPV, posterior hyaloid peeling, APC, and C3F8 tamponade is a highly effective alternative technique with stable anatomical and functional results. PMID:26543348

  1. Minimal invasive localization of the germinal disc in ovo for subsequent chicken sexing using optical coherence tomography

    NASA Astrophysics Data System (ADS)

    Burkhardt, Anke; Geissler, Stefan; Cimalla, Peter; Walther, Julia; Koch, Edmund

    2010-02-01

    Reason for using optical coherence tomography (OCT) to locate the germinal disc is the questionable and ethically alarming killing of male layer chickens because for the layer line only the females are necessary. To avoid this and to protect the animal rights, the sex of the fertilized chicken egg has to be determined as early as possible in the unincubated state. Because the information whether the chick becomes male or female can be found in the germinal disc an accurate localization for sexing is essential. The germinal disc is located somewhere on top of the yolk and has a diameter of approximately 4 - 5 mm. Different imaging methods like ultrasonography, 3D-X-ray micro computed tomography and magnetic resonance imaging were used for localization until now, but found to be impractical. The goal of this study is to prove if OCT can be a moderate approach for the precise in ovo localization. Because the eggshell is an impenetrable barrier for OCT and to minimize the penetration of germs a very small hole is placed in the eggshell and a fan-shaped optical scanning pattern is used.

  2. 78 FR 55292 - Certain Optical Disc Drives, Components Thereof, and Products Containing the Same; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ...disc drives, components thereof, and products containing the same. The complaint names as respondents Lenovo Group Ltd. of Hong Kong; Lenovo (United States) Inc. of NC; LG Electronics, Inc. of South Korea; LG Electronics U.S.A.,...

  3. Obtaining optic disc center and pixel region by automatic thresholding methods on morphologically processed fundus images.

    PubMed

    Marin, Diego; Gegundez-Arias, Manuel E; Suero, Angel; Bravo, Jose M

    2015-02-01

    Development of automatic retinal disease diagnosis systems based on retinal image computer analysis can provide remarkably quicker screening programs for early detection. Such systems are mainly focused on the detection of the earliest ophthalmic signs of illness and require previous identification of fundal landmark features such as optic disc (OD), fovea or blood vessels. A methodology for accurate center-position location and OD retinal region segmentation on digital fundus images is presented in this paper. The methodology performs a set of iterative opening-closing morphological operations on the original retinography intensity channel to produce a bright region-enhanced image. Taking blood vessel confluence at the OD into account, a 2-step automatic thresholding procedure is then applied to obtain a reduced region of interest, where the center and the OD pixel region are finally obtained by performing the circular Hough transform on a set of OD boundary candidates generated through the application of the Prewitt edge detector. The methodology was evaluated on 1200 and 1748 fundus images from the publicly available MESSIDOR and MESSIDOR-2 databases, acquired from diabetic patients and thus being clinical cases of interest within the framework of automated diagnosis of retinal diseases associated to diabetes mellitus. This methodology proved highly accurate in OD-center location: average Euclidean distance between the methodology-provided and actual OD-center position was 6.08, 9.22 and 9.72 pixels for retinas of 910, 1380 and 1455 pixels in size, respectively. On the other hand, OD segmentation evaluation was performed in terms of Jaccard and Dice coefficients, as well as the mean average distance between estimated and actual OD boundaries. Comparison with the results reported by other reviewed OD segmentation methodologies shows our proposal renders better overall performance. Its effectiveness and robustness make this proposed automated OD location and segmentation method a suitable tool to be integrated into a complete prescreening system for early diagnosis of retinal diseases. PMID:25433912

  4. Detection of the optic disc in fundus images by combining probability models.

    PubMed

    Harangi, Balazs; Hajdu, Andras

    2015-10-01

    In this paper, we propose a combination method for the automatic detection of the optic disc (OD) in fundus images based on ensembles of individual algorithms. We have studied and adapted some of the state-of-the-art OD detectors and finally organized them into a complex framework in order to maximize the accuracy of the localization of the OD. The detection of the OD can be considered as a single-object detection problem. This object can be localized with high accuracy by several algorithms extracting single candidates for the center of the OD and the final location can be defined using a single majority voting rule. To include more information to support the final decision, we can use member algorithms providing more candidates which can be ranked based on the confidence ordered by the algorithms. In this case, a spatial weighted graph is defined where the candidates are considered as its nodes, and the final OD position is determined in terms of finding a maximum-weighted clique. Now, we examine how to apply in our ensemble-based framework all the accessible information supplied by the member algorithms by making them return confidence values for each image pixel. These confidence values inform us about the probability that a given pixel is the center point of the object. We apply axiomatic and Bayesian approaches, as in the case of aggregation of judgments of experts in decision and risk analysis, to combine these confidence values. According to our experimental study, the accuracy of the localization of OD increases further. Besides single localization, this approach can be adapted for the precise detection of the boundary of the OD. Comparative experimental results are also given for several publicly available datasets. PMID:26259029

  5. Central Retinal Venous Pressure in Eyes of Normal-Tension Glaucoma Patients with Optic Disc Hemorrhage

    PubMed Central

    Kim, Ko Eun; Kim, Dong Myung; Flammer, Josef; Kim, Kyoung Nam

    2015-01-01

    Objective To compare central retinal venous pressure (CRVP) among eyes with and without optic disc hemorrhage (ODH) in bilateral normal-tension glaucoma (NTG) patients and NTG eyes without an episode of ODH. Methods In this prospective study, 22 bilateral NTG patients showing a unilateral ODH and 29 bilateral NTG patients without an episode of ODH were included. Eyes were categorized into group A (n = 22, eyes with ODH), group B (n = 22, fellow eyes without ODH), and group C (n = 29, NTG eyes without an episode of ODH). A contact lens ophthalmodynamometer was used to measure CRVP and central retinal arterial pressure (CRAP). Results Intraocular pressure (IOP) measured on the day of contact lens ophthalmodynamometry showed no difference among groups. However, the mean baseline IOP in group A was significantly lower than that in group C (P = .008). The CRVP in group A (29.1 ± 10.8 mmHg) was significantly lower than that in group C (40.1 ± 8.8 mmHg, P = .001), but similar to that in group B (30.5 ± 8.7 mmHg, P = .409). A similar relationship was noted for CRAP. No significant eye-associated variable for ODH was found in group A and B by conditional logistic regression analysis (all P > 0.05). However, multivariate logistic regression analysis in groups A and C revealed that low mean baseline IOP (odds ratio [OR] = 0.69, 95% confidence interval [CI] 0.49-0.98, P = 0.043) and low CRVP (OR = 0.88, 95% CI 0.80-0.95, P = 0.003) were associated with ODH. Conclusions CRVP was lower in NTG eyes with ODH than in eyes without an episode of ODH, but similar to that of fellow eyes without ODH. These imply less likelihood of association between increased central retinal venous resistance and ODH. PMID:25996599

  6. Analysis of Disturbance on Differential Push-Pull Tracking with Dual-Layer Optical Disc

    NASA Astrophysics Data System (ADS)

    Itonaga, Makoto; Eguchi, Hideharu; Sakurauchi, Kiyoshi; Saito, Toshiya

    2008-07-01

    In this paper, we analyze the disturbance of tracking error signal caused by layer cross talk on playback of a dual-layer disc. We will reveal the origin of the disturbance by experiments using a special disc. The origin is the groove of the cross-talk layer. Furthermore, we will investigate other related factors that increase the disturbance. Tangential tilt and variation of space layer thickness in one revolution are such factors.

  7. Uveal melanomas near the optic disc or fovea. Visual results after proton beam irradiation

    SciTech Connect

    Seddon, J.M.; Gragoudas, E.S.; Egan, K.M.; Glynn, R.J.; Munzenrider, J.E.; Austin-Seymour, M.; Goitein, M.; Verhey, L.; Urie, M.; Koehler, A.

    1987-04-01

    Proximity to the disc and fovea is a risk factor for visual loss after proton beam irradiation of uveal melanomas. Of 562 eyes treated over a 10-year period with pretreatment visual acuity of 20/200 or better, 363 (64.6%) contained tumors within 2 disc diameters (DD) of the disc or fovea. Rates of visual loss after treatment to worse than 20/200 and causes of visual decline were evaluated using Kaplan-Meier analysis. Cumulative rates of visual loss among subjects with tumors near the disc or fovea were 33 and 47% 1 and 2 years after treatment compared to 17 and 28%, respectively, for subjects with tumors located farther from both structures. The leading cause of visual loss in the first year among eyes with tumors near the disc or fovea was retinal detachment. Controlling for other predictors of visual loss to worse than 20/200, location near the disc or fovea was independently related to visual loss primarily due to retinal detachment, cataract, and radiation retinopathy. Despite the unfavorable location of these tumors, over half of patients with 20/200 or better pretreatment visual acuity had useful vision 2 years after treatment.

  8. The Advanced Glaucoma Intervention Study (AGIS): 10. Variability among academic glaucoma subspecialists in assessing optic disc notching.

    PubMed Central

    Gaasterland, D E; Blackwell, B; Dally, L G; Caprioli, J; Katz, L J; Ederer, F

    2001-01-01

    PURPOSE: An analysis of data from the Advanced Glaucoma Intervention Study (AGIS) has found eyes reported to have partial optic disc rim notching (not to the edge) at baseline to have less risk of subsequent visual field loss than eyes with no notching. Because this is counterintuitive and because classification of notching had not been defined in the AGIS protocol, we have assessed AGIS ophthalmologists interobserver and intraobserver agreement on notching. METHODS: Fourteen glaucoma subspecialists classified notching in 26 pairs of stereoscopic disc photographs of eyes with mild to severe glaucomatous optic neuropathy. They classified images as showing either no notching, notching not to the edge, or notching to the edge. Several hours later, 10 of them classified the same images a second time. RESULTS: In an analysis of interobserver agreement, of 26 stereoscopic images, a plurality of ophthalmologists classified notching as absent in 9 (35%), as present but not to the edge in 7 (27%), and as present and not to the edge in 10 (38%). All 14 ophthalmologists (100%) agreed on the classification of 7 (27%) of the images, and 13 of the 14 ophthalmologists (93%) agreed on the classification of 4 additional images (15%). Of these 11 images with at least 93% agreement, notching was reported as absent in 3 (27%) and to the edge in 8 (73%). In the remaining 15 images, there was substantial disagreement about whether notching was present and, if so, whether it was to the edge. In an analysis of intraobserver agreement, none of the 10 ophthalmologists who completed the viewing a second time classified all eyes exactly the same as the first time, though 5 ophthalmologists made 4 or fewer reclassifications. Overall, 80% of the original classifications were reproduced on second reading. Of the initial classifications that were not reproduced, slightly more than half were first classified as having notching not to the edge. CONCLUSION: Without definitions or examples of optic disc rim notching, the glaucoma subspecialists had relatively high intraobserver agreement but were likely to disagree with each other in characterizing the degree of disc rim notching. We recommend development of a standard photographic classification of disc rim notching. The classification should be tested for inter- and intra-observer agreement. PMID:11797305

  9. Comparison of optical and electrical investigations of meat ageing

    NASA Astrophysics Data System (ADS)

    Prokopyeva, Elena; Tománek, Pavel; Kocová, Lucie; Palai-Dany, Tomáš; Balík, Zden?k.; Škarvada, Pavel; Grmela, Lubomír.

    2013-05-01

    Different ultrasonic, electromagnetic, electrical and optical methods are used for meat ageing detection. Muscles are turbid anisotropic media, they exhibit changes in electrical and optical properties according to the direction of the electrical and optical fields in the sample. The work assesses the feasibility of impedance measurements for meat ageing detection and their comparison with optical measurement of scattered light. The pork chop slices were used for their relative homogeneity. An investigation was carried out for the detection of the ageing of unpacked slices exposed directly to the air, and other packed in polyethylene bags. The electrical method is a promising method due to the possibility of getting much information and realizing cheap and fast enough measurement systems. The optical method allows measure the rotation of polarization plane in the range of 95 degrees within considered period. Nevertheless, further work has to be provided to determine closer relationships between optical scattering characteristics, electrical anisotropy in ageing-related tissue structural properties.

  10. Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area.

    PubMed

    Khor, Chiea Chuen; Ramdas, Wishal D; Vithana, Eranga N; Cornes, Belinda K; Sim, Xueling; Tay, Wan-Ting; Saw, Seang-Mei; Zheng, Yingfeng; Lavanya, Raghavan; Wu, Renyi; Wang, Jie Jin; Mitchell, Paul; Uitterlinden, André G; Rivadeneira, Fernando; Teo, Yik-Ying; Chia, Kee-Seng; Seielstad, Mark; Hibberd, Martin; Vingerling, Johannes R; Klaver, Caroline C W; Jansonius, Nomdo M; Tai, E-Shyong; Wong, Tien-Yin; van Duijn, Cornelia M; Aung, Tin

    2011-05-01

    Damage to the optic nerve (e.g. from glaucoma) has an adverse and often irreversible impact on vision. Earlier studies have suggested that the size of the optic nerve head could be governed by hereditary factors. We conducted a genome-wide association study (GWAS) on 4445 Singaporean individuals (n = 2132 of Indian and n = 2313 of Malay ancestry, respectively), with replication in Rotterdam, the Netherlands (n = 9326 individuals of Caucasian ancestry) using the most widely reported parameter for optic disc traits, the optic disc area. We identified a novel locus on chromosome 22q13.1, CARD10, which strongly associates with optic disc area in both Singaporean cohorts as well as in the Rotterdam Study (RS; rs9607469, per-allele change in optic disc area = 0.051 mm(2); P(meta) = 2.73×10(-12)) and confirmed the association between CDC7/TGFBR3 (lead single nucleotide polymorphism (SNP) rs1192415, P(meta) = 7.57×10(-17)) and ATOH7 (lead SNP rs7916697, P(meta) = 2.00 × 10(-15)) and optic disc area in Asians. This is the first Asian-based GWAS on optic disc area, identifying a novel locus for the optic disc area, but also confirming the results found in Caucasian persons suggesting that there are general genetic determinants applicable to the size of the optic disc across different ethnicities. PMID:21307088

  11. Transient accretion disc-like envelope in the symbiotic binary BF Cygni during its 2006-2015 optical outburst

    NASA Astrophysics Data System (ADS)

    Tomov, N. A.; Tomova, M. T.; Bisikalo, D. V.

    2015-09-01

    The optical light of the symbiotic binary BF Cyg during its last eruption after 2006 shows orbital variations because of an eclipse of the outbursting compact object. The first orbital minimum is deeper than the following ones. Moreover, the Balmer profiles of this system acquired additional satellite components indicating a bipolar collimated outflow at one time between the first and second orbital minima. This behaviour is interpreted in the framework of the model of a collimated stellar wind from the outbursting object. It is supposed that one extended disc-like envelope covering the accretion disc of the compact object and collimating its stellar wind forms in the period between the first and second minima. The uneclipsed part of this envelope is responsible for the decrease of the depth of the orbital minimum. The calculated U BVR_{ C}I_{ C} fluxes of this uneclipsed part are in agreement with the observed residual of the depths of the first and second orbital minima. The parameters of the envelope require that it is the main emitting region of the line H? but the H? profile is less determined from its rotation and mostly from other mechanisms. It is concluded that the envelope is a transient nebular region and its destruction determines the increase of the depth of the orbital minimum with fading of the optical light.

  12. The Origin of UV-optical Variability in AGN and Test of Disc Models: XMM-Newton and ground based observations of NGC4395

    E-print Network

    McHardy, Ian; Peterson, Brad; Bieryla, Allyson; Chand, Hum; Elvis, Martin; Emmanoulopoulos, Dimitrios; Falco, Emilio; Gandhi, Poshak; Kaspi, Shai; Latham, David; Lira, Paulina; McCully, Curtis; Netzer, Hagai; Uemura, Makoto

    2016-01-01

    The origin of short timescale (weeks/months) variability of AGN, whether due to intrinsic disc variations or reprocessing of X-ray emission by a surrounding accretion disc, has been a puzzle for many years. However recently a number of observational programmes, particularly of NGC5548 with Swift, have shown that the UV/optical variations lag behind the X-ray variations in a manner strongly supportive of X-ray reprocessing. Somewhat surprisingly the implied size of the accretion disc is ~3x greater than expected from a standard, smooth, Shakura-Sunyaev thin disc model. Although the difference may be explained by a clumpy accretion disc, it is not clear whether the difference will occur in all AGN or whether it may change as, eg, a function of black hole mass, accretion rate or disc temperature. Measurements of interband lags for most AGN require long timescale monitoring, which is hard to arrange. However for low mass (<1 million solar mass) AGN, the combination of XMM-Newton EPIC (X-rays) with the optical ...

  13. Function and morphology in macular retinoschisis associated with optic disc pit in a child before and after its spontaneous resolution.

    PubMed

    Polunina, Anna A; Todorova, Margarita G; Palmowski-Wolfe, Anja M

    2012-04-01

    Optic disc pit (ODP) is a rare congenital defect within the optic nerve head. Macula elevation associated with ODP develops in 75-93% of the adult patients. Macular involvement in children with optic disc pit is rare, and only a few cases have been published to date. In the present case, we have observed morphology and function of the central retina in a child with ODP-associated macular detachment and following its spontaneous resolution. An 8-year-old white boy diagnosed with a macular detachment in an eye with an ODP. Optical coherent tomography (OCT) and multifocal electroretinography (mfERG), as well as visual acuity and visual field, were performed in the follow-up of the unilateral schisis-like retinal detachment. A large retinoschisis associated with ODP in a child showed a tendency to spontaneously resolve at 3 months, which was confirmed on OCT. At this time, an mfERG revealed markedly reduced responses. Despite morphologic reattachment at follow-up and improvement in visual acuity, increased mfERG responses were still not the same as in the fellow healthy eye. In contrast to the OCT which is very helpful to assess the extent of the neurosensory detachment, the mfERG offers an additional tool for follow-up of retinal function in this disorder. The good visual outcome in our patient shows that in the presence of residual retinal function on mfERG and in the absence of further lesions on OCT, follow-up is a valid option in children with an ODP-associated macular detachment. PMID:22322392

  14. A novel collinear optical system with annulus mirrors for holographic disc driver

    NASA Astrophysics Data System (ADS)

    Wang, Ye

    2008-12-01

    This paper focus on a novel collinear lens system with annulus mirrors for holographic disc driver, both information beam and reference beam are use same laser beam. The expanded and parallel laser beam, center part of it as the information beam then through Fourier transform lens, the beam around center part as a reference beam. On this axis, the ring reference beam reflected by two annulus shaped mirrors, then became a convergent beam, together with the information beam which through the first Fourier transform lens then produce holographic pattern to be write into the holographic disc behind of them, this lens system with two mirrors made the angle between information beam and reference beam more wide, can improved the multiplex level of holographic storage. Pair of Fourier transform lens with advance performance is designed in this paper.

  15. A search for eclipsing binaries that host discs

    NASA Astrophysics Data System (ADS)

    Meng, Zeyang; Quillen, Alice C.; Bell, Cameron P. M.; Mamajek, Eric E.; Scott, Erin L.; Zhou, Ji-Lin

    2014-07-01

    We search for systems hosting eclipsing discs using a complete sample of eclipsing binaries (EBs); those previously identified in the third phase of the Optical Gravitational Lensing Experiment (OGLE-III). Within a subsample of 2823 high-cadence, high-photometric precision and large eclipsing depth detached EBs previously identified in the Large Magellanic Cloud (LMC), we find that the skewness and kurtosis of the light-curve magnitude distribution within the primary eclipse can distinguish EBs with a complex-shaped eclipse from those without. Two systems with previously identified eclipsing discs (OGLE-LMC-ECL-11893 and OGLE-LMC-ECL-17782) are identified with near zero skewness (|S| < 0.5) and positive kurtosis. No additional eclipsing disc systems were found in the OGLE-III LMC, Small Magellanic Cloud or Galactic Disc EB light curves. We estimate that the fraction of detached early-type LMC EBs (which have a primary with an I-band magnitude brighter than ?19 mag) that exhibit atypical eclipses and so could host a disc is approximately 1/1000. As circumstellar disc lifetimes are short, we expected to primarily find eclipsing discs around young stars. In addition, as there is more room for a disc in a widely separated binary and because a disc close to a luminous star would be above the dust sublimation temperature, we expected to primarily find eclipsing discs in long-period binaries. However, OGLE-LMC-ECL-17782 is a 13.3 d period B star system with a transient and hot (˜6000 K, ˜0.1 au radius) disc and Scott et al. estimate an age of 150 Myr for OGLE-LMC-ECL-11893. Both discs are unexpected in the EB sample and impel explanation.

  16. Retinal Nerve Fiber and Optic Disc Morphology in Patients with Human Immunodeficiency Virus Using the Heidelberg Retina Tomography 3

    PubMed Central

    Bartsch, Dirk-Uwe; Kozak, Igor; Grant, Igor; Knudsen, Victoria L.; Weinreb, Robert N.; Lee, Byung Ro; Freeman, William R.

    2015-01-01

    Purpose To use novel confocal scanning ophthalmoscopy technology to test hypothesis that HIV-seropositive patients without history of retinitis with a history of a low CD4 count are more likely to have damage to their retinal nerve fiber layer (RNFL) when compared to patients with high CD4 count. In addition, we compared optic disc morphologic changes with glaucoma. Design Cross-sectional study. Participants and Controls 171 patients were divided into four groups. The control group consisted of 40 eyes of 20 HIV-seronegative patients. The second group consisted of 80 eyes of 41 HIV-positive patients whose CD4 cell count never dropped below 100 (1.0 x 109/L). The third group consisted of 44 eyes of 26 HIV-positive patients with a history of low CD4 counts <100. Fourth group consisted of 79 eyes of 79 patients with confirmed glaucoma who served as positive controls. Testing Confocal scanning laser ophthalmoscopy was performed with the Heidelberg Retina Tomograph (HRT3) and data were analyzed with HRT3, software (Heyex version 1.5.10.0). Main Outcome Measures Disc area, cup area, cup volume, rim volume, mean cup depth, maximum cup depth, cup-to-disc ration, mean RNFL thickness, and RNFL cross-sectional area. Results Analysis of the global optic nerve and cup parameters showed no difference in disk area among the four groups. There was also no difference in cup, rim volume, mean cup depth, or maximum cup depth among the first three groups but they were all different from glaucoma group. The RNFL was thinner in glaucoma and both HIV-positive groups compared to HIV-seronegative subjects. The cross sectional RNFL area was thinner in both high and low CD4 HIV-positive groups compared to HIV-seronegative group in the nasal and temporal/inferior sectors, respectively. Glaucoma group showed thinning in all sectors. Conclusions HIV retinopathy results in retinal nerve fiber layer loss without structural optic nerve supportive tissue change. RNFL damage may occur early in HIV disease by mechanism different than in glaucoma. PMID:26258547

  17. Optics in the Age of Euler

    NASA Astrophysics Data System (ADS)

    Hakfoort, Casper

    1995-01-01

    This book studies the eighteenth-century origins and early phase of a fundamental debate in optics: whether light is a particle or wave. Specifically, it is the first in-depth study of the contents and reception of Leonhard Euler's wave theory of light. The author shows that contrary to what has been assumed, the debate did not start in 1672 with Newton's particle theory of light. Rather, it only really got under way after Euler published his wave theory in 1746. He also corrects the misapprehension that Newton's theory was prevalently held in Germany in the early years of the debate, but really only became dominant around 1795. In his discussion, Professor Hakfoort demonstrates in dramatic fashion the relevance of chemical experiments on physical optics. Finally, in the epilogue, the author reflects on the mathematical, experimental, and metaphysical aspects of physical optics that shaped early modern science.

  18. Retrobulbar blood flow and visual organ function disturbance in the course of giant cell arteritis coexisting with optic disc drusen – a case report

    PubMed Central

    Post, Micha?; Milchert, Marcin

    2013-01-01

    The review presented ophthalmologic syndrome connected with visual organ function disorder in giant cell arteritis patient concomitant with optic nerve disc drusen. Diagnostic difficulties were shown in relation to incidence of both similar ophthalmic symptoms as well as interpretation of specialists examinations results (pattern visual evoked potential test, scanning laser polarimetry, and perimetric tests – kinetic and static). Apart from ophthalmic investigations, significant role of radiological examinations was considered, especially color Doppler ultrasonography of retrobulbar circulation – optic artery, central retinal artery, long posterior ciliary arteries. Adequate interpretation of results seems to be crucial to establish scheme and timing of treatment in case of co-occurrence of the abovementioned disorders. In the presented case early implementation of steroid therapy resulted in improvement of blood flow parameters and the regression of ophthalmological complaints. Visual field deficiency in kinetic perimetry, reduced wave amplitude p100 in visual evoked potential test as well as decrease in number of optic nerve fibers in optic nerve disc region in scanning laser polarimetry exam can be diagnostic features in diagnosis of visual impairment in the course of giant cell arteritis and optic nerve disc drusen. Evaluation of blood flow velocity parameters in retrobulbar arteries in color Doppler ultrasonography is the most valuable screening in monitoring ophthalmic dysregulation in presented disorders.

  19. Ultrafast nonlinear optical properties of dye-doped PMMA discs irradiated by 40 fs laser pulses

    NASA Astrophysics Data System (ADS)

    Xia, Yuanqin; Jiang, Yugang; Fan, Rongwei; Dong, Zhiwei; Zhao, Weijiang; Chen, Deying; Umesh, G.

    2009-09-01

    The two-photon absorption (TPA) characteristics of PMMA discs doped with three different dyes were studied using an fs-pulsed Ti-Sapphire laser as the pump source, and employing the open-aperture Z-scan technique. TPA cross-sections obtained for PMMA doped with the dyes PM597, DCM and rhodamine 6G-rhodamine B (co-doped) were found to be equal to 24.7, 33.3 and 32.3 GM, respectively (1 GM=10 -50 cm 4 s phot -1 mol -1). Furthermore, two-photon fluorescence was measured for the samples containing DCM and rhodamine 6G-rhodamine B (co-doped). Compared to the one-photon fluorescence spectrum, the peaks in the two-photon fluorescence spectrum were red shifted and the extent of red shift increased with increasing doping concentration. We have also observed that the red shift in the two-photon fluorescence peak of the samples in the solid form is much larger than that in the solution state. This phenomenon could be explained by a twisted intra-molecular charge transfer model.

  20. A trifurcated fiber-optic-probe-based optical system designed for AGEs measurement

    NASA Astrophysics Data System (ADS)

    Wang, Yikun; Zhang, Long; Zhu, Ling; Liu, Yong; Zhang, Gong; Wang, An

    2012-03-01

    Advanced Glycation End-products (AGEs) are biochemical end-products of non-enzymatic glycation and are formed irreversibly in human serum and skin tissue. AGEs are thought to play an important role in the pathogenesis of diabetes and corresponding complications. All conventional methods for measuring AGEs must take sampling and measure in vitro. These methods are invasive and have the problem of relatively time-consuming. AGEs have fluorescent characteristics. Skin AGEs can be assessed noninvasively by collecting the fluorescence emitted from skin tissue when excited with proper light. However, skin tissue has absorption and scattering effects on fluorescence of AGEs, it is not reliable to evaluate the accumulation of AGEs according the emitted fluorescence but not considering optical properties of skin tissue. In this study, a portable system for detecting AGEs fluorescence and skin reflectance spectrum simultaneously has been developed. The system mainly consists of an ultraviolet light source, a broadband light source, a trifurcated fiber-optic probe, and a compact charge coupled device (CCD) spectrometer. The fiber-optic probe consists of 36 optical fibers which are connected to the ultraviolet light source, 6 optical fibers connected to the broadband light source, and a core fiber connected to the CCD spectrometer. Demonstrative test measurements with the system on skin tissue of 40 healthy subjects have been performed. Using parameters that are calculated from skin reflectance spectrum, the distortion effects caused by skin absorption and scattering can be eliminated, and the integral intensity of corrected fluorescence has a strong correlation with the accumulation of AGEs. The system looks very promising for both laboratory and clinical applications to monitor AGEs related diseases, especially for chronic diabetes and complications.

  1. A trifurcated fiber-optic-probe-based optical system designed for AGEs measurement

    NASA Astrophysics Data System (ADS)

    Wang, Yikun; Zhang, Long; Zhu, Ling; Liu, Yong; Zhang, Gong; Wang, An

    2011-11-01

    Advanced Glycation End-products (AGEs) are biochemical end-products of non-enzymatic glycation and are formed irreversibly in human serum and skin tissue. AGEs are thought to play an important role in the pathogenesis of diabetes and corresponding complications. All conventional methods for measuring AGEs must take sampling and measure in vitro. These methods are invasive and have the problem of relatively time-consuming. AGEs have fluorescent characteristics. Skin AGEs can be assessed noninvasively by collecting the fluorescence emitted from skin tissue when excited with proper light. However, skin tissue has absorption and scattering effects on fluorescence of AGEs, it is not reliable to evaluate the accumulation of AGEs according the emitted fluorescence but not considering optical properties of skin tissue. In this study, a portable system for detecting AGEs fluorescence and skin reflectance spectrum simultaneously has been developed. The system mainly consists of an ultraviolet light source, a broadband light source, a trifurcated fiber-optic probe, and a compact charge coupled device (CCD) spectrometer. The fiber-optic probe consists of 36 optical fibers which are connected to the ultraviolet light source, 6 optical fibers connected to the broadband light source, and a core fiber connected to the CCD spectrometer. Demonstrative test measurements with the system on skin tissue of 40 healthy subjects have been performed. Using parameters that are calculated from skin reflectance spectrum, the distortion effects caused by skin absorption and scattering can be eliminated, and the integral intensity of corrected fluorescence has a strong correlation with the accumulation of AGEs. The system looks very promising for both laboratory and clinical applications to monitor AGEs related diseases, especially for chronic diabetes and complications.

  2. Polarimetric microlensing of circumstellar discs

    NASA Astrophysics Data System (ADS)

    Sajadian, Sedighe; Rahvar, Sohrab

    2015-12-01

    We study the benefits of polarimetry observations of microlensing events to detect and characterize circumstellar discs around the microlensed stars located at the Galactic bulge. These discs which are unresolvable from their host stars make a net polarization effect due to their projected elliptical shapes. Gravitational microlensing can magnify these signals and make them be resolved. The main aim of this work is to determine what extra information about these discs can be extracted from polarimetry observations of microlensing events in addition to those given by photometry ones. Hot discs which are closer to their host stars are more likely to be detected by microlensing, owing to more contributions in the total flux. By considering this kind of discs, we show that although the polarimetric efficiency for detecting discs is similar to the photometric observation, but polarimetry observations can help to constraint the disc geometrical parameters e.g. the disc inner radius and the lens trajectory with respect to the disc semimajor axis. On the other hand, the time-scale of polarimetric curves of these microlensing events generally increases while their photometric time-scale does not change. By performing a Monte Carlo simulation, we show that almost four optically thin discs around the Galactic bulge sources are detected (or even characterized) through photometry (or polarimetry) observations of high-magnification microlensing events during 10-yr monitoring of 150 million objects.

  3. Alteration of lunar optical properties: age and composition effects.

    PubMed

    Adams, J B; McCord, T B

    1971-02-12

    A model for lunar surface processes is presented which explains the main albedo and color contrasts and the temporal changes in these optical properties. Evidence from Apollo 11 and Apollo 12 samples and telescopic spectral reflectivity measurements indicates that the maria are similar in mineralogy on a regional scale and that the highlands are consistent with an anorthositic-gabbro composition. Bright craters and rays in both regions expose materials that are relatively crystalline compared with their backgrounds, which are richer in dark glass. With age, bright craters and rays in the maria darken in place by meteorite impact-induced vitrification and mixing with the surrounding material. Highland bright craters and rays may, however, darken primarily through regional contamination by iron- and titanium-rich mare material. PMID:17734782

  4. Color naming, lens aging, and grue: What the optics of the aging eye can teach us about color language

    E-print Network

    Kay, Paul

    1 Color naming, lens aging, and grue: What the optics of the aging eye can teach us about color University of California, Davis Medical Center Christina M. Frederick Department of Psychology, University subjects in the proportion of blue color-name responses. Color naming for stimuli that were nominally green

  5. Artificial Disc Replacement

    MedlinePLUS

    ... treat this condition, alternatives to disc replacement include fusion, nonoperative care or no treatment. Typically, surgery is ... operative treatment for disc pain has been spinal fusion. This is a surgical procedure in which disc ...

  6. Debris discs in binaries: a numerical study

    E-print Network

    Thebault, Philippe; Augereau, Jean-Charles

    2010-01-01

    Debris disc analysis and modelling provide crucial information about the structure and the processes at play in extrasolar planetary systems. In binary systems, this issue is more complex because the disc should in addition respond to the companion star's perturbations. We explore the dynamical evolution of a collisionally active debris disc for different initial parent body populations, diverse binary configurations and optical depths. We focus on the radial extent and size distribution of the disc at a stationary state. We numerically follow the evolution of $10^{5}$ massless small grains, initially produced from a circumprimary disc of parent bodies following a size distribution in $dN \\propto s^{-3.5}$ds . Grains are submitted to both stars' gravity as well as radiation pressure. In addition, particles are assigned an empirically derived collisional lifetime. For all the binary configurations the disc extends far beyond the critical semimajor axis $a_crit$ for orbital stability. This is due to the steady ...

  7. The impacts of ageing effects due to radiation burden on optical fiber couplers

    NASA Astrophysics Data System (ADS)

    Perecar, F.; Marcinka, O.; Bednarek, L.; Lucki, M.; Liner, A.; Hajek, L.; Papes, M.; Jaros, J.; Vasinek, V.

    2015-08-01

    The paper discuss about accelerated ageing of optical fiber elements in their burdened with gamma radiation. In addition to the destruction of coating materials, gamma radiation has its effect on the internal structure of the optical fiber. It is necessary to specify the changes in the optical coupler and find out why these changes occur. This article contains experimental measurement of the impact of gamma radiation Cobalt-60 on the optical couplers of various split performance ratio. The couplers were exposed to gradually increasing doses of 60Co. Measurements are focused on the overall distribution of the energy in the core and cladding various branches of SM optical fiber couplers. This article focuses on applied research and experimental development of resources for safety operation of optical networks since monitoring of ageing substantially contributes to its security. It addresses issues of accelerated ageing of optical fiber elements in their burdened with gamma radiation. How does radiation energy of gamma radiation influence optical network elements? This effect is explored just very little bit and is yet another unanswered question. In addition to the destruction of coating materials, gamma radiation has its effect on the internal structure of the optical fiber. It is necessary to specify the changes in the optical coupler and find out why these changes occur. This article contains experimental measurement of the impact of gamma radiation Cobalt-60 on the optical couplers of various split performance ratio. Optical passive components, couplers, were exposed to gradually increasing doses of 60Co. Measurements are focused on the overall distribution of the energy of LP01 mode in the core and cladding various branches of SM optical fiber couplers. Graphical and mathematical detect changes in the dissemination of energy coupler after single doses of gamma radiation are useful to understand the phenomenon of accelerated ageing elements of optical networks in environments with an increased incidence of radiation energy. Keywords: 2-D view, 3-D view, coupler, gamma radiation, Cobalt-60, ageing, energy

  8. Adaptive optics-assisted optical coherence tomography for imaging of patients with age related macular degeneration

    NASA Astrophysics Data System (ADS)

    Sudo, Kenta; Cense, Barry

    2013-03-01

    We developed an optical coherence tomography (OCT) prototype with a sample arm that uses a 3.4 mm beam, which is considerably larger than the 1.2 to 1.5 mm beam that is used in commercialized OCT systems. The system is equipped with adaptive optics (AO), and to distinguish it from traditional AO-OCT systems with a larger 6 mm beam we have coined this concept AO-assisted OCT. Compared to commercialized OCT systems, the 3.4 mm aperture combined with AO improves light collection efficiency and imaging lateral resolution. In this paper, the performance of the AOa-OCT system was compared to a standard OCT system and demonstrated for imaging of age-related macular degeneration (AMD). Measurements were performed on the retinas of three human volunteers with healthy eyes and on one eye of a patient diagnosed with AMD. The AO-assisted OCT system imaged retinal structures of healthy human eyes and a patient eye affected by AMD with higher lateral resolution and a 9° by 9° field of view. This combination of a large isoplanatic patch and high lateral resolution can be expected to fill a gap between standard OCT with a 1.2 mm beam and conventional AO-OCT with a 6 mm beam and a 1.5° by 1.5° isoplanatic patch.

  9. Percutaneous diode laser disc nucleoplasty

    NASA Astrophysics Data System (ADS)

    Menchetti, P. P.; Longo, Leonardo

    2004-09-01

    The treatment of herniated disc disease (HNP) over the years involved different miniinvasive surgical options. The classical microsurgical approach has been substituted over the years both by endoscopic approach in which is possible to practice via endoscopy a laser thermo-discoplasty, both by percutaneous laser disc nucleoplasty. In the last ten years, the percutaneous laser disc nucleoplasty have been done worldwide in more than 40000 cases of HNP. Because water is the major component of the intervertebral disc, and in HNP pain is caused by the disc protrusion pressing against the nerve root, a 980 nm Diode laser introduced via a 22G needle under X-ray guidance and local anesthesia, vaporizes a small amount of nucleous polposus with a disc shrinkage and a relief of pressure on nerve root. Most patients get off the table pain free and are back to work in 5 to 7 days. Material and method: to date, 130 patients (155 cases) suffering for relevant symptoms therapy-resistant 6 months on average before consulting our department, have been treated. Eightyfour (72%) males and 46 (28%) females had a percutaneous laser disc nucleoplasty. The average age of patients operated was 48 years (22 - 69). The level of disc removal was L3/L4 in 12 cases, L4/L5 in 87 cases and L5/S1 in 56 cases. Two different levels were treated at the same time in 25 patients. Results: the success rate at a minimum follow-up of 6 months was 88% with a complication rate of 0.5%.

  10. Intervertebral disc degeneration: evidence for two distinct phenotypes

    PubMed Central

    Adams, Michael A; Dolan, Patricia

    2012-01-01

    We review the evidence that there are two types of disc degeneration. ‘Endplate-driven’ disc degeneration involves endplate defects and inwards collapse of the annulus, has a high heritability, mostly affects discs in the upper lumbar and thoracic spine, often starts to develop before age 30 years, usually leads to moderate back pain, and is associated with compressive injuries such as a fall on the buttocks. ‘Annulus-driven’ disc degeneration involves a radial fissure and/or a disc prolapse, has a low heritability, mostly affects discs in the lower lumbar spine, develops progressively after age 30 years, usually leads to severe back pain and sciatica, and is associated with repetitive bending and lifting. The structural defects which initiate the two processes both act to decompress the disc nucleus, making it less likely that the other defect could occur subsequently, and in this sense the two disc degeneration phenotypes can be viewed as distinct. PMID:22881295

  11. A study of axonal degeneration in the optic nerves of aging mice

    NASA Technical Reports Server (NTRS)

    Johnson, J. E., Jr.; Philpott, D. E.; Miquel, J.

    1978-01-01

    The optic nerves of C57BL/6J mice ranging from 3 to 30 months were examined by electron microscopy. At all ages investigated, optic nerve axons contained enlarged mitochondria with abnormal cristae. With increasing age, a large number of necrotic axons were observed and were in the process of being phagocytized. The abnormal mitochondria may represent preliminary changes that eventually lead to necrosis of the axon.

  12. Black hole accretion disc impacts

    E-print Network

    Pihajoki, Pauli

    2015-01-01

    We present an analytic model for computing the luminosity and spectral evolution of flares caused by a supermassive black hole impacting the accretion disc of another supermassive black hole. Our model includes photon diffusion, emission from optically thin regions and relativistic corrections to the observed spectrum and time-scales. We test the observability of the impact scenario with a simulated population of quasars hosting supermassive black hole binaries. The results indicate that for a moderate binary mass ratio of 0.3, and impact distances of 100 primary Schwarzschild radii, the accretion disc impacts can be expected to equal or exceed the host quasar in brightness at observed wavelength {\\lambda} = 510 nm up to z = 0.6. We conclude that accretion disc impacts may function as an independent probe for supermassive black hole binaries. We release the code used for computing the model light curves to the community.

  13. Herschel-PACS observations of discs in the ? Chamaeleontis association

    NASA Astrophysics Data System (ADS)

    Riviere-Marichalar, P.; Elliott, P.; Rebollido, I.; Bayo, A.; Ribas, A.; Merín, B.; Kamp, I.; Dent, W. R. F.; Montesinos, B.

    2015-12-01

    Context. Protoplanetary discs are the birthplace of planets. Studying protoplanetary discs is the key to constraining theories of planet formation. By observing dust and gas in associations at different ages we can study the evolution of these discs, their clearing timescales, and their physical and geometrical properties.The stellar association ? Cha is peculiar; some members still retain detectable amounts of gas in their discs at the late age of ~7 Myr, making it one of the most interesting young stellar associations in the solar neighbourhood. Aims: We characterise the properties of dust and gas in protoplanetary and transitional discs in the ? Cha young cluster, with special emphasis on explaining the peculiarities that lead to the observed high disc detection fraction and prominent IR excesses at an age of ~7 Myr. Methods: We observed 17 members of the ? Cha association with Herschel-PACS in photometric mode and line spectroscopic mode. A subset of members were also observed in range spectroscopic mode. The observations trace [OI] and H2O emissions at 63.18 and 63.32 ?m, respectively, as well as CO, OH, CH+, and [CII] at different wavelengths for those systems observed in range mode. The photometric observations were used to build complete spectral energy distributions (SEDs) from the optical to the far-IR. High-resolution multi-epoch optical spectra with high signal-to-noise ratios were also analysed to study the multiplicity of the sources and look for further gas (accreting) and outflow indicators. Results: We detect four out of fifteen sources observed at 70 ?m, four out of six at 100 ?m, and six out of sixteen at 160 ?m. Only one system shows [OI] emission at 63 ?m, namely RECX 15 or J0843.3-7905. None of them shows far-IR line emission at any other wavelength. The [OI] emission toward RECX 15 points to the presence of an outflow; however, the emission is not extended. We study H? emission among ? Cha members and conclude that RECX 4, 5, 9, 11, and 15 are actively accreting in at least one epoch. Conclusions: The SEDs of the discs in ? Cha show a variety of shapes, from those in Taurus and in Upper Scorpius to sources showing excess over the Taurus median SED. Furthermore, the SEDs of RECX 3 and RECX 4 are typical of debris discs. The detection fraction for [OI] in ? Cha is lower than younger regions like Taurus and Cha II, indicative of an evolutionary trend. The lack of [OI] emission, together with the intermediate values of the IR excess, can be explained by long-lived discs with a flattened geometry or by flared discs with a low UV flux, or by a combination of the two scenarios. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.

  14. Does Posterior Capsule Opacification Affect the Results of Diagnostic Technologies to Evaluate the Retina and the Optic Disc?

    PubMed Central

    Garcia-Medina, Jose Javier; del Rio-Vellosillo, Monica; Zanon-Moreno, Vicente; Santos-Bueso, Enrique; Gallego-Pinazo, Roberto; Ferreras, Antonio; Pinazo-Duran, Maria Dolores

    2015-01-01

    The visual outcome obtained after cataract removal may progressively decline because of posterior capsular opacification (PCO). This condition can be treated by creating an opening in the posterior lens capsule by Nd:YAG laser capsulotomy. PCO optical imperfections cause several light reflection, refraction, and diffraction phenomena, which may interfere with the functional and structural tests performed in different ocular locations for the diagnosis and follow-up of ocular disease, like macular and optic nerve diseases. Some parameters measured by visual field examinations, scanning laser polarimetry, and optical coherence tomography (OCT) have changed after PCO removal. Imaging quality also changes following capsulotomy. Consequently, the results of ancillary tests in pseudophakic eyes for studying ocular diseases like glaucoma or maculopathies should be correlated with other clinical examinations, for example, slit-lamp biomicroscopy or funduscopy. If PCO is clinically significant, a new baseline should be set for future comparisons following capsulotomy when using automated perimetry and scanning laser polarimetry. To perform OCT in the presence of PCO, reliable examinations (considering signal strength) apparently guarantee that measurements are not influenced by PCO. PMID:26167499

  15. ON THE AGE AND METALLICITY ESTIMATION OF SPIRAL GALAXIES USING OPTICAL AND NEAR-INFRARED PHOTOMETRY

    E-print Network

    Lee, Hyun-chul

    ON THE AGE AND METALLICITY ESTIMATION OF SPIRAL GALAXIES USING OPTICAL AND NEAR-INFRARED PHOTOMETRY-infrared photometry show surprisingly orthogonal grids as age and metallicity are varied, and they are coming headinggs: galaxies: abundances -- galaxies: evolution -- galaxies: photometry -- galaxies: spiral

  16. Study of the shape of an optical window in a super-resolution state by electromagnetic-thermal coupled simulation: Effects of melting of an active layer in an optical disc

    SciTech Connect

    Sano, Haruyuki; Shima, Takayuki; Kuwahara, Masashi; Fujita, Yoshiya; Uchiyama, Munehisa; Aono, Yoshiyuki

    2014-04-21

    We performed a multi-physics simulation for the propagation of electromagnetic waves and heat conduction in a super-resolution optical disc that includes an active layer of InSb. Because the change in the optical constant of InSb due to the phase transition is taken into account, the melting of the active layer can be realistically simulated in our calculation. It was found that in the case of an incident light power (P) of 2 mW, a profile of the electric field intensity transmitted through the InSb layer has an asymmetric shape with a narrow peak. This beam-narrowing was suggested to be an essential mechanism of the super-resolution, because a narrower light beam allows the detection of a smaller pit structure than the optical diffraction limit. This beam-narrowing was found to be originating from a small molten region produced in the InSb layer, which works as a mask for light exposure.

  17. Forced exercise protects the aged optic nerve against intraocular pressure injury.

    PubMed

    Chrysostomou, Vicki; Kezic, Jelena M; Trounce, Ian A; Crowston, Jonathan G

    2014-07-01

    We have previously shown that the optic nerve of mice becomes increasingly vulnerable to injury with advancing age. Here, we investigated whether regular exercise can modify this age-related vulnerability and improve optic nerve recovery after injury. Aged (12-month-old) C57BL/6J mice were exercised by swimming for 60 min/d, 5 d/wk for 6 weeks. After 5 weeks, injury to the optic nerve was induced by short-term elevation of intraocular pressure. Retinal function was recorded using the electroretinogram and the cellular and biochemical changes induced by injury were assessed using immunohistochemistry and quantitative polymerase chain reaction. We found that exercise almost completely reversed age-related vulnerability of the optic nerve to injury such that exercised aged mice had a similar functional response to injury as non-exercised young (3-month-old) mice. Exercise also abrogated injury-induced astrocytic gliosis and macrophage activation in the aged retina. These data suggest that the known benefits of exercise also extend to the visual system and support further investigation of physical activity as a means of protecting against injury, dysfunction, and degeneration in the aging eye. PMID:24524967

  18. Stability of a hot two-temperature accretion disc with advection

    E-print Network

    Xue-Bing Wu

    1997-08-01

    The effects of radial advection and thermal diffusion were considered in investigating the linear stability of an optically thin, two-temperature accretion disc. If the disc has only very little advection, we proved that the thermal instability exists when the disc is geometrically thin. But it dispears in a geometrically slim disc if the thermal diffusion was considered. Moreover, if the disc is advection dominated, the thermal instability does not exist. In addition, we found that the instabilities of inertial-acoustic modes exist only in a geometrically thin disc or an advection-dominated disc with low Mach number, whereas the Lightman & Eardley viscous instability always dispears in a two-temperature disc. A simple comparison also showed that an optically thin, bremsstrahlung cooling dominated disc is generally more thermally unstable than a two-temperature disc if it is not advection-dominated.

  19. A revised burial dose estimation procedure for optical dating of youngand modern-age sediments

    USGS Publications Warehouse

    Arnold, L.J.; Roberts, R.G.; Galbraith, R.F.; DeLong, S.B.

    2009-01-01

    The presence of genuinely zero-age or near-zero-age grains in modern-age and very young samples poses a problem for many existing burial dose estimation procedures used in optical (optically stimulated luminescence, OSL) dating. This difficulty currently necessitates consideration of relatively simplistic and statistically inferior age models. In this study, we investigate the potential for using modified versions of the statistical age models of Galbraith et??al. [Galbraith, R.F., Roberts, R.G., Laslett, G.M., Yoshida, H., Olley, J.M., 1999. Optical dating of single and multiple grains of quartz from Jinmium rock shelter, northern Australia: Part I, experimental design and statistical models. Archaeometry 41, 339-364.] to provide reliable equivalent dose (De) estimates for young and modern-age samples that display negative, zero or near-zero De estimates. For this purpose, we have revised the original versions of the central and minimum age models, which are based on log-transformed De values, so that they can be applied to un-logged De estimates and their associated absolute standard errors. The suitability of these 'un-logged' age models is tested using a series of known-age fluvial samples deposited within two arroyo systems from the American Southwest. The un-logged age models provide accurate burial doses and final OSL ages for roughly three-quarters of the total number of samples considered in this study. Sensitivity tests reveal that the un-logged versions of the central and minimum age models are capable of producing accurate burial dose estimates for modern-age and very young (<350??yr) fluvial samples that contain (i) more than 20% of well-bleached grains in their De distributions, or (ii) smaller sub-populations of well-bleached grains for which the De values are known with high precision. Our results indicate that the original (log-transformed) versions of the central and minimum age models are still preferable for most routine dating applications, since these age models are better suited to the statistical properties of typical single-grain and multi-grain single-aliquot De datasets. However, the unique error properties of modern-age samples, combined with the problems of calculating natural logarithms of negative or zero-Gy De values, mean that the un-logged versions of the central and minimum age models currently offer the most suitable means of deriving accurate burial dose estimates for very young and modern-age samples. ?? 2009 Elsevier Ltd. All rights reserved.

  20. Automotive disc brake squeal

    NASA Astrophysics Data System (ADS)

    Kinkaid, N. M.; O'Reilly, O. M.; Papadopoulos, P.

    2003-10-01

    Disc brake squeal remains an elusive problem in the automotive industry. Since the early 20th century, many investigators have examined the problem with experimental, analytical, and computational techniques, but there is as yet no method to completely suppress disc brake squeal. This paper provides a comprehensive review and bibliography of works on disc brake squeal. In an effort to make this review accessible to a large audience, background sections on vibrations, contact and disc brake systems are also included.

  1. Turbine disc sealing assembly

    DOEpatents

    Diakunchak, Ihor S.

    2013-03-05

    A disc seal assembly for use in a turbine engine. The disc seal assembly includes a plurality of outwardly extending sealing flange members that define a plurality of fluid pockets. The sealing flange members define a labyrinth flow path therebetween to limit leakage between a hot gas path and a disc cavity in the turbine engine.

  2. Changes in diffusion path length with old age in diffuse optical tomography

    NASA Astrophysics Data System (ADS)

    Bonnéry, Clément; Leclerc, Paul-Olivier; Desjardins, Michèle; Hoge, Rick; Bherer, Louis; Pouliot, Philippe; Lesage, Frédéric

    2012-05-01

    Diffuse, optical near infrared imaging is increasingly being used in various neurocognitive contexts where changes in optical signals are interpreted through activation maps. Statistical population comparison of different age or clinical groups rely on the relative homogeneous distribution of measurements across subjects in order to infer changes in brain function. In the context of an increasing use of diffuse optical imaging with older adult populations, changes in tissue properties and anatomy with age adds additional confounds. Few studies investigated these changes with age. Duncan et al. measured the so-called diffusion path length factor (DPF) in a large population but did not explore beyond the age of 51 after which physiological and anatomical changes are expected to occur [Pediatr. Res. 39(5), 889-894 (1996)]. With increasing interest in studying the geriatric population with optical imaging, we studied changes in tissue properties in young and old subjects using both magnetic resonance imaging (MRI)-guided Monte-Carlo simulations and time-domain diffuse optical imaging. Our results, measured in the frontal cortex, show changes in DPF that are smaller than previously measured by Duncan et al. in a younger population. The origin of these changes are studied using simulations and experimental measures.

  3. Optical properties of neonatal skin measured in vivo as a function of age and skin pigmentation

    NASA Astrophysics Data System (ADS)

    Bosschaart, Nienke; Mentink, Rosaline; Kok, Joke H.; van Leeuwen, Ton G.; Aalders, Maurice C. G.

    2011-09-01

    Knowledge of the optical properties of neonatal skin is invaluable when developing new, or improving existing optical techniques for use at the neonatal intensive care. In this article, we present in vivo measurements of the absorption ?a and reduced scattering coefficient ?s' of neonatal skin between 450 and 600 nm and assess the influence of age and skin pigmentation on the optical properties. The optical properties were measured using a spatially resolved, steady state diffuse reflectance spectroscopy setup, combined with a modified spatially resolved diffusion model. The method was validated on phantoms with known values for the absorption and reduced scattering coefficient. Values of ?a and ?s' were obtained from the skin at four different body locations (forehead, sternum, hand, and foot) of 60 neonates with varying gestational age, postnatal age, and skin pigmentation. We found that ?a ranged from 0.02 to 1.25 mm-1 and ?s' was in the range of 1 to 2.8 mm-1 (5th to 95th percentile of the patient population), independent of body location. In contrast to previous studies, no to very weak correlation was observed between the optical properties and gestational maturity, but a strong dependency of the absorption coefficient on postnatal age was found for dark skinned patients.

  4. Long-term monitoring of the archetype Seyfert galaxy MCG-6-30-15: X-ray, optical and near-IR variability of the corona, disc and torus

    NASA Astrophysics Data System (ADS)

    Lira, P.; Arévalo, P.; Uttley, P.; McHardy, I. M. M.; Videla, L.

    2015-11-01

    We present long-term monitoring of MCG-6-30-15 in X-rays, optical and near-IR wavelengths, collected over 5 yr of monitoring. We determine the power spectrum density of all the observed bands and show that after taking into account the host contamination similar power is observed in the optical and near-IR bands. There is evidence for a correlation between the light curves of the X-ray photon flux and the optical B band, but it is not possible to determine a lag with certainty, with the most likely value being around 0 d. Strong correlation is seen between the optical and near-IR bands. Cross-correlation analysis shows some complex probability distributions and lags that range from 10 to 20 d, with the near-IR following the optical variations. Filtering the light curves in frequency space shows that the strongest correlations are those corresponding to the shortest time-scales. We discuss the nature of the X-ray variability and conclude that this is intrinsic and cannot be accounted for by absorption episodes due to material intervening in the line of sight. It is also found that the lags agree with the relation ? ? ?4/3, as expected for an optically thick geometrically thin accretion disc, although for a larger disc than that predicted by the estimated black hole mass and accretion rate in MCG-6-30-15. The cross-correlation analysis suggests that the torus is located at ˜20 light-days from the central source and at most at ˜50 light-days from the central region. This implies an active galactic nucleus bolometric luminosity of ˜3 × 1043 erg s-1 cm-2.

  5. Assessment of fiber optic sensors for aging monitoring of industrial liquid coolants

    NASA Astrophysics Data System (ADS)

    Riziotis, Christos; El Sachat, Alexandros; Markos, Christos; Velanas, Pantelis; Meristoudi, Anastasia; Papadopoulos, Aggelos

    2015-03-01

    Lately the demand for in situ and real time monitoring of industrial assets and processes has been dramatically increased. Although numerous sensing techniques have been proposed, only a small fraction can operate efficiently under harsh industrial environments. In this work the operational properties of a proposed photonic based chemical sensing scheme, capable to monitor the ageing process and the quality characteristics of coolants and lubricants in industrial heavy machinery for metal finishing processes is presented. The full spectroscopic characterization of different coolant liquids revealed that the ageing process is connected closely to the acidity/ pH value of coolants, despite the fact that the ageing process is quite complicated, affected by a number of environmental parameters such as the temperature, humidity and development of hazardous biological content as for example fungi. Efficient and low cost optical fiber sensors based on pH sensitive thin overlayers, are proposed and employed for the ageing monitoring. Active sol-gel based materials produced with various pH indicators like cresol red, bromophenol blue and chorophenol red in tetraethylorthosilicate (TEOS), were used for the production of those thin film sensitive layers deposited on polymer's and silica's large core and highly multimoded optical fibers. The optical characteristics, sensing performance and environmental robustness of those optical sensors are presented, extracting useful conclusions towards their use in industrial applications.

  6. The avian intervertebral disc arises from rostral sclerotome and lacks a nucleus pulposus: Implications for evolution of the vertebrate disc

    PubMed Central

    Bruggeman, Bradley J.; Maier, Jennifer A.; Mohiuddin, Yasmin S.; Powers, Rae; Lo, YinTing; Guimarães-Camboa, Nuno; Evans, Sylvia M.; Harfe, Brian D.

    2012-01-01

    Deterioration of the intervertebral discs is an unfortunate consequence of aging. The intervertebral disc in mammals is composed of three parts: a jelly-like center called the nucleus pulposus, the cartilaginous annulus fibrosus and anterior and posterior endplates that attach the discs to vertebrae. In order to understand the origin of the disc, we have investigated the intervertebral region of chickens. Surprisingly, our comparison of mouse and chicken discs revealed that chicken discs lack nuclei pulposi. In addition, the notochord, which in mice forms nuclei pulposi, was found to persist as a rod-like structure and express Shh throughout chicken embryogenesis. Our fate mapping data indicates that cells originating from the rostral half of each somite are responsible for forming the avian disc while cells in the caudal region of each somite form vertebrae. A histological analysis of mammalian and non-mammalian organisms suggests that nuclei pulposi are only present in mammals. PMID:22354863

  7. Stem Cell Approaches to Intervertebral Disc Regeneration: Obstacles from the Disc Microenvironment.

    PubMed

    Wang, Feng; Shi, Rui; Cai, Feng; Wang, Yun-Tao; Wu, Xiao-Tao

    2015-11-01

    Intervertebral disc (IVD) degeneration results in segmental instability and irritates neural compressive symptoms, such as low back pain and motor deficiency. The transplanting of stem cell into degenerative discs has attracted increasing clinical attention, as a new and proven approach to alleviating disc degeneration and to relieving discogenic pains. Aside from supplementation with stem cells, the IVD itself already contains a pool of stem and progenitor cells. Since the resident disc stem cells are incapable of reversing the pathologic changes that occur during aging and disc degeneration, it has been debated as to whether transplanted stem cells are capable of providing an efficient and durable therapeutic effect, even though there have been positive outcomes in both animal models and in clinical trials. This review aims to decipher the interactions between the stem cell and the disc microenvironment. Within their new niches in the IVD, the exogenous stem cell shows metabolic adaptation to the low-glucose supply, hypoxia, and compressive loadings, but demonstrates little tolerance to the disc-like acidity and hypertonicity. Similarly, the survival of endogenous stem cells is threatened as well by the harsh disc microenvironment, which may exhaust the stem cell resources and restrict the self-repair capacity of a degenerating IVD. To eliminate the intrinsic obstacles within the stressful disc niches, stem cells should be delivered with an injectable scaffold that provides both survival and mechanical support. Quick healing or concretion of the injection injuries, which minimizes stem cell leakage and disturbance to disc homeostasis, is of equal importance toward achieving efficient stem cell-based disc regeneration. PMID:26228642

  8. Radially truncated galactic discs

    E-print Network

    Richard de Grijs; Michiel Kregel; Karen H. Wesson

    2001-02-02

    We present the first results of a systematic analysis of radially truncated exponential discs for four galaxies of a complete sample of disc-dominated edge-on spiral galaxies. The discs of our sample galaxies are truncated at similar radii on either side of their centres. With possible the exception of the disc of ESO 416-G25, it appears that the truncations in our sample galaxies are closely symmetric, in terms of both their sharpness and the truncation length. However, the truncations occur over a larger region and not as abruptly as found in previous studies. We show that the truncated luminosity distributions of our sample galaxies, if also present in the mass distributions, comfortably meet the requirements for longevity. The formation and maintenance of disc truncations are likely closely related to stability requirements for galactic discs.

  9. High-definition optical coherence tomography intrinsic skin ageing assessment in women: a pilot study.

    PubMed

    Boone, M A L M; Suppa, M; Marneffe, A; Miyamoto, M; Jemec, G B E; Del Marmol, V

    2015-10-01

    Several non-invasive two-dimensional techniques with different lateral resolution and measurable depth range have proved to be useful in assessing and quantifying morphological changes in skin ageing. Among these, only in vivo microscopy techniques permit histometric measurements in vivo. Qualitative and quantitative assessment of chronological (intrinsic) age-related (IAR) morphological changes of epidermis, dermo-epidermal junction (DEJ), papillary dermis (PD), papillary-reticular dermis junction and reticular dermis (RD) have been performed by high-definition optical coherence tomography in real time 3-D. HD-OCT images were taken at the internal site of the right upper arm. Qualitative HD-OCT IAR descriptors were reported at skin surface, at epidermal layer, DEJ, PD and upper RD. Quantitative evaluation of age-related compaction and backscattered intensity or brightness of different skin layers was performed by using the plugin plot z-axis profile of ImageJ(®) software permitting intensity assessment of HD-OCT (DICOM) images (3-D images). Analysis was in blind from all clinical information. Sixty, fair-skinned (Fitzpatrick types I-III) healthy females were analysed retrospectively in this study. The subjects belonged to three age groups: twenty in group I aged 20-39, twenty in group II aged 40-59 and twenty in group III aged 60-79. Only intrinsic ageing in women has been studied. Significant age-related qualitative and quantitative differences could be noticed. IAR changes in dermal matrix fibers morphology/organisation and in microvasculature were observed. The brightness and compaction of the different skin layers increased significantly with intrinsic skin ageing. The depth of visibility of fibers in RD increased significantly in the older age group. In conclusion, HD-OCT allows 3-D in vivo and real time qualitative and quantitative assessment of chronological (intrinsic) age-related morphological skin changes at high resolution from skin surface to a depth of the superficial reticular dermis. PMID:26066511

  10. MRI evaluation of spontaneous intervertebral disc degeneration in the alpaca cervical spine.

    PubMed

    Stolworthy, Dean K; Bowden, Anton E; Roeder, Beverly L; Robinson, Todd F; Holland, Jacob G; Christensen, S Loyd; Beatty, Amanda M; Bridgewater, Laura C; Eggett, Dennis L; Wendel, John D; Stieger-Vanegas, Susanne M; Taylor, Meredith D

    2015-12-01

    Animal models have historically provided an appropriate benchmark for understanding human pathology, treatment, and healing, but few animals are known to naturally develop intervertebral disc degeneration. The study of degenerative disc disease and its treatment would greatly benefit from a more comprehensive, and comparable animal model. Alpacas have recently been presented as a potential large animal model of intervertebral disc degeneration due to similarities in spinal posture, disc size, biomechanical flexibility, and natural disc pathology. This research further investigated alpacas by determining the prevalence of intervertebral disc degeneration among an aging alpaca population. Twenty healthy female alpacas comprised two age subgroups (5 young: 2-6 years; and 15 older: 10+ years) and were rated according to the Pfirrmann-grade for degeneration of the cervical intervertebral discs. Incidence rates of degeneration showed strong correlations with age and spinal level: younger alpacas were nearly immune to developing disc degeneration, and in older animals, disc degeneration had an increased incidence rate and severity at lower cervical levels. Advanced disc degeneration was present in at least one of the cervical intervertebral discs of 47% of the older alpacas, and it was most common at the two lowest cervical intervertebral discs. The prevalence of intervertebral disc degeneration encourages further investigation and application of the lower cervical spine of alpacas and similar camelids as a large animal model of intervertebral disc degeneration. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1776-1783, 2015. PMID:26135031

  11. Aging Related Changes of Retina and Optic Nerve of Uromastyx aegyptia and Falco tinnunculus

    PubMed Central

    2013-01-01

    Aging is a biological phenomenon that involves gradual degradation of the structure and function of the retina and optic nerve. To our knowledge, little is known about the aging-related ocular cell loss in avian (Falco tinnunculus) and reptilian species (Uromastyx aegyptia). A selected 90 animals of pup, middle, and old age U. aegyptia (reptilian) and F. tinnunculus (avian) were used. The retinae and optic nerves were investigated by light and transmission electron microscopy (TEM) and assessments of neurotransmitters, antioxidant enzymes (catalase, superoxide dismustase and glutathione s transferase), caspase-3 and -7, malonadialdhyde, and DNA fragmentation. Light and TEM observations of the senile specimens revealed apparent deterioration of retinal cell layers, especially the pigmented epithelium and photoreceptor outer segments. Their inclusions of melanin were replaced by lipofuscins. Also, vacuolar degeneration and demyelination of the optic nerve axons were detected. Concomitantly, there was a marked increase of oxidative stress involved reduction of neurotransmitters and antioxidant enzymes and an increase of lipid peroxidation, caspase-3 and -7, subG0/G1 apoptosis, and P53. We conclude that aging showed an inverse relationship with the neurotransmitters and antioxidant enzymes and a linear relationship of caspases, malondialdhyde, DNA apoptosis, and P53 markers of cell death. These markers reflected the retinal cytological alterations and lipofuscin accumulation within inner segments. PMID:24215233

  12. Autonomous Optical Sensor System for the Monitoring of Nitrogen Dioxide from Aging Rocket Propellant

    SciTech Connect

    COX, TRISHA D.; SINGH, SEEMA; HUNTER, JOHN A.; JONES, GARY D.; SINCLAIR, MICHAEL B.; ROHWER, LAUREN E. S.; POHL, PHILLIP I.; ANDRZEJEWSKI, WILLIAM; SASAKI, DARRYL Y.

    2001-09-01

    An optical sensor system has been developed for the autonomous monitoring of NO{sub 2} evolution in energetic material aging studies. The system is minimally invasive, requiring only the presence of a small sensor film within the aging chamber. The sensor material is a perylene/PMMA film that is excited by a blue LED light source and the fluorescence detected with a CCD spectrometer. Detection of NO{sub 2} gas is done remotely through the glass window of the aging chamber. Irreversible reaction of NO{sub 2} with perylene, producing the non-fluorescent nitroperylene, provides the optical sensing scheme. The rate of fluorescence intensity loss over time can be modeled using a numerical solution to the coupled diffusion and a nonlinear chemical reaction problem to evaluate NO{sub 2} concentration levels. The light source, spectrometer, spectral acquisition, and data processing were controlled through a Labivew program run by a laptop PC. Due to the long times involved with materials aging studies the system was designed to turn on, warm up, acquire data, power itself off, then recycle at a specific time interval. This allowed the monitoring of aging HE material over the period of several weeks with minimal power consumption and stable LED light output. Despite inherent problems with gas leakage of the aging chamber they were able to test the sensor system in the field under an accelerated aging study of rocket propellant. They found that the propellant evolved NO{sub 2} at a rate that yielded a concentration of between 10 and 100 ppm. The sensor system further revealed that the propellant, over an aging period of 25 days, evolves NO{sub 2} with cyclic behavior between active and dormant periods.

  13. Relationship between Initial Telomere Length, Initial Telomerase Activity, Age, and Replicative Capacity of Nucleus Pulposus Chondrocytes in Human Intervertebral Discs: What Is a Predictor of Replicative Potential?

    PubMed Central

    Lee, Jun-Seok; Jeong, Seo-Won; Cho, Sung-Wook; Juhn, Joon-Pyo; Kim, Ki-Won

    2015-01-01

    There is evidence that telomere length (TL), telomerase activity (TA), and age are related to the replicative potential of human nucleus pulposus chondrocytes (NPCs). However, it has not yet been established if any of these factors can serve as predictors of the replicative potential of NPCs. To establish predictors of the replicative potential of NPCs, we evaluated potential relationships between replicative capacity of NPCs, initial TL (telomere length at the first passage), initial TA (telomerase activity at the first passage), and age. Nucleus pulposus specimens were obtained from 14 patients of various ages undergoing discectomy. NPCs were serially cultivated until the end of their replicative lifespans. Relationships among cumulative population doubling level (PDL), initial TL, initial TA, and age were analyzed. Initial TA was negatively correlated with age (r = -0.674, P = 0.008). However, no correlation between initial TL and age was observed. Cumulative PDL was also negatively correlated with age (r = -0.585, P = 0.028). Although the cumulative PDL appeared to increase with initial TL or initial TA, this trend was not statistically significant. In conclusion, age is the sole predictor of the replicative potential of human NPCs, and replicative potential decreases with age. Initial TL and initial TA are not predictors of replicative potential, and can serve only as reference values. PMID:26633809

  14. Reconstructing the star formation history of the Milky Way disc(s) from chemical abundances

    NASA Astrophysics Data System (ADS)

    Snaith, O.; Haywood, M.; Di Matteo, P.; Lehnert, M. D.; Combes, F.; Katz, D.; Gómez, A.

    2015-06-01

    We develop a chemical evolution model to study the star formation history of the Milky Way. Our model assumes that the Milky Way has formed from a closed-box-like system in the inner regions, while the outer parts of the disc have experienced some accretion. Unlike the usual procedure, we do not fix the star formation prescription (e.g. Kennicutt law) to reproduce the chemical abundance trends. Instead, we fit the abundance trends with age to recover the star formation history of the Galaxy. Our method enables us to recover the star formation history of the Milky Way in the first Gyrs with unprecedented accuracy in the inner (R < 7-8 kpc) and outer (R > 9-10 kpc) discs, as sampled in the solar vicinity. We show that half the stellar mass formed during the thick-disc phase in the inner galaxy during the first 4-5 Gyr. This phase was followed by a significant dip in star formation activity (at 8-9 Gyr) and a period of roughly constant lower-level star formation for the remaining 8 Gyr. The thick-disc phase has produced as many metals in 4 Gyr as the thin-disc phase in the remaining 8 Gyr. Our results suggest that a closed-box model is able to fit all the available constraints in the inner disc. A closed-box system is qualitatively equivalent to a regime where the accretion rate maintains a high gas fraction in the inner disc at high redshift. In these conditions the SFR is mainly governed by the high turbulence of the interstellar medium. By z ~ 1 it is possible that most of the accretion takes place in the outer disc, while the star formation activity in the inner disc is mostly sustained by the gas that is not consumed during the thick-disc phase and the continuous ejecta from earlier generations of stars. The outer disc follows a star formation history very similar to that of the inner disc, although initiated at z ~ 2, about 2 Gyr before the onset of the thin-disc formation in the inner disc.

  15. Discovery of the Fomalhaut C debris disc

    NASA Astrophysics Data System (ADS)

    Kennedy, G. M.; Wyatt, M. C.; Kalas, P.; Duchêne, G.; Sibthorpe, B.; Lestrade, J.-F.; Matthews, B. C.; Greaves, J.

    2014-02-01

    Fomalhaut is one of the most interesting and well-studied nearby stars, hosting at least one planet, a spectacular debris ring and two distant low-mass stellar companions (TW PsA and LP 876-10, a.k.a. Fomalhaut B and C). We observed both companions with Herschel, and while no disc was detected around the secondary, TW PsA, we have discovered the second debris disc in the Fomalhaut system, around LP 876-10. This detection is only the second case of two debris discs seen in a multiple system, both of which are relatively wide (?3000 au for HD 223352/40 and 158 kau [0.77 pc] for Fomalhaut/LP 876-10). The disc is cool (24 K) and relatively bright, with a fractional luminosity Ldisc/L? = 1.2 × 10-4, and represents the rare observation of a debris disc around an M dwarf. Further work should attempt to find if the presence of two discs in the Fomalhaut system is coincidental, perhaps simply due to the relatively young system age of 440 Myr, or if the stellar components have dynamically interacted and the system is even more complex than it currently appears.

  16. Demographics of transition discs in Ophiuchus and Taurus

    NASA Astrophysics Data System (ADS)

    Najita, Joan R.; Andrews, Sean M.; Muzerolle, James

    2015-07-01

    Transition disc systems are young stars that appear to be on the verge of dispersing their protoplanetary discs. We explore the nature of these systems by comparing the stellar accretion rates dot{M}_* and disc masses Md of transition discs and normal T Tauri stars in Taurus and Ophiuchus. After controlling for the known dependences of dot{M}_* and Md on age, dot{M}_* on stellar mass and Md on the presence of stellar or substellar companions, we find that the normal T Tauri stars show a trend of dot{M}_* increasing with Md. The transition discs tend to have higher average disc masses than normal T Tauri stars as well as lower accretion rates than normal T Tauri stars of the same disc mass. These results are most consistent with the interpretation that the transition discs have formed objects massive enough to alter the accretion flow, i.e. single or multiple giant planets. Several Ophiuchus T Tauri stars that are not known transition disc systems also have very low accretion rates for their disc masses. We speculate on the possible nature of these sources.

  17. An optical age chronology of late Quaternary extreme fluvial events recorded in Ugandan dambo soils

    USGS Publications Warehouse

    Mahan, S.A.; Brown, D.J.

    2007-01-01

    There is little geochonological data on sedimentation in dambos (seasonally saturated, channel-less valley floors) found throughout Central and Southern Africa. Radiocarbon dating is problematic for dambos due to (i) oxidation of organic materials during dry seasons; and (ii) the potential for contemporary biological contamination of near-surface sediments. However, for luminescence dating the equatorial site and semi-arid climate facilitate grain bleaching, while the gentle terrain ensures shallow water columns, low turbidity, and relatively long surface exposures for transported grains prior to deposition and burial. For this study, we focused on dating sandy strata (indicative of high-energy fluvial events) at various positions and depths within a second-order dambo in central Uganda. Blue-light quartz optically stimulated luminescences (OSL) ages were compared with infrared stimulated luminescence (IRSL) and thermoluminescence (TL) ages from finer grains in the same sample. A total of 8 samples were dated, with 6 intervals obtained at ???35, 33, 16, 10.4, 8.4, and 5.9 ka. In general, luminescence ages were stratigraphically, geomorphically and ordinally consistent and most blue-light OSL ages could be correlated with well-dated climatic events registered either in Greenland ice cores or Lake Victoria sediments. Based upon OSL age correlations, we theorize that extreme fluvial dambo events occur primarily during relatively wet periods, often preceding humid-to-arid transitions. The optical ages reported in this study provide the first detailed chronology of dambo sedimentation, and we anticipate that further dambo work could provide a wealth of information on the paleohydrology of Central and Southern Africa. ?? 2006 Elsevier Ltd. All rights reserved.

  18. Disc in flames: Roles of TNF-? and IL-1? in intervertebral disc degeneration.

    PubMed

    Johnson, Z I; Schoepflin, Z R; Choi, H; Shapiro, I M; Risbud, M V

    2015-01-01

    The intervertebral disc is an important mechanical structure that allows range of motion of the spinal column. Degeneration of the intervertebral disc--incited by aging, traumatic insult, genetic predisposition, or other factors--is often defined by functional and structural changes in the tissue, including excessive breakdown of the extracellular matrix, increased disc cell senescence and death, as well as compromised biomechanical function of the tissue. Intervertebral disc degeneration is strongly correlated with low back pain, which is a highly prevalent and costly condition, significantly contributing to loss in productivity and health care costs. Disc degeneration is a chronic, progressive condition, and current therapies are limited and often focused on symptomatic pain relief rather than curtailing the progression of the disease. Inflammatory processes exacerbated by cytokines tumour necrosis factor-? (TNF-?) and interleukin-1? (IL-1?) are believed to be key mediators of disc degeneration and low back pain. In this review, we describe the contributions of TNF-? and IL-1? to changes seen during disc degeneration at both cellular and tissue level, as well as new evidence suggesting a link between infection of the spine and low back pain, and the emerging therapeutic modalities aimed at combating these processes. PMID:26388614

  19. Association of age and macular pigment optical density using dual-wavelength autofluorescence imaging

    PubMed Central

    Lima, Verônica Castro; Rosen, Richard B; Prata, Tiago Santos; Dorairaj, Syril; Spielberg, Leigh; Maia, Mauricio; Sallum, Juliana M

    2013-01-01

    Background Several lines of evidence suggest that macular pigment may play a protective role against age-related macular degeneration, but the influence of age on macular pigment density levels remains unclear. This study was designed to investigate the relationship between age and the normal distribution of macular pigment optical density (MPOD) values surrounding the fovea. Methods Consecutive healthy subjects with no evidence of ocular disease were enrolled in this study. After inclusion, MPOD values were measured at specific eccentricities (0.5, 1, and 2 degrees) from the foveal center using a dual-wavelength autofluorescence method employing a modified confocal scanning laser ophthalmoscope. Whenever both eyes were eligible, one was randomly selected for analysis. The correlation between age and MPOD values was investigated using regression analysis. Results Thirty subjects (30 eyes) were included (mean age 48.6 ± 16.4 [range 23–77] years). Significant differences were found between MPOD values measured at 0.5, 1, and 2 degrees from the center of the fovea (0.49 ± 0.12 density units, 0.37 ± 0.11 density units, and 0.13 ± 0.05 density units, respectively, P < 0.05). Significant correlations between age and MPOD values at 0.5 and 1 degree were found (P ? 0.02). Values measured at 2 degrees did not correlate significantly with age (P = 0.06). Conclusion In healthy subjects, MPOD values were highest near the foveal center. These values appeared to increase during adulthood (peak at 45–50 years), followed by a gradual reduction after 60 years of age. PMID:23589675

  20. On total disc replacement.

    PubMed

    Berg, Svante

    2011-02-01

    Low back pain consumes a large part of the community's resources dedicated to health care and sick leave. Back disorders also negatively affect the individual leading to pain suffering, decreased quality-of-life and disability. Chronic low back pain (CLBP) due to degenerative disc disease (DDD) is today often treated with fusion when conservative treatment has failed and symptoms are severe. This treatment is as successful as arthroplasty is for hip arthritis in restoring the patient's quality of life and reducing disability. Even so, there are some problems with this treatment, one of these being recurrent CLBP from an adjacent segment (ASD) after primarily successful surgery. This has led to the development of alternative surgical treatments and devices that maintain or restore mobility, in order to reduce the risk for ASD. Of these new devices, the most frequently used are the disc prostheses used in Total Disc Replacement (TDR). This thesis is based on four studies comparing total disc replacement with posterior fusion. The studies are all based on a material of 152 patients with DDD in one or two segments, aged 20-55 years that were randomly treated with either posterior fusion or TDR. The first study concerned clinical outcome and complications. Follow-up was 100% at both one and two years. It revealed that both treatment groups had a clear benefit from treatment and that patients with TDR were better in almost all outcome scores at one-year follow-up. Fusion patients continued to improve during the second year. At two-year follow-up there was a remaining difference in favour of TDR for back pain. 73% in the TDR group and 63% in the fusion group were much better or totally pain-free (n.s.), while twice as many patients in the TDR group were totally pain free (30%) compared to the fusion group (15%). Time of surgery and total time in hospital were shorter in the TDR group. There was no difference in complications and reoperations, except that seventeen of the patients in the fusion group were re-operated for removal of their implants. The second study concerned sex life and sexual function. TDR is performed via an anterior approach, an approach that has been used for a long time for various procedures on the lumbar spine. A frequent complication reported in males when this approach is used is persistent retrograde ejaculation. The TDR group in this material was operated via an extra-peritoneal approach to the retroperitoneal space, and there were no cases of persistent retrograde ejaculation. There was a surprisingly high frequency of men in the fusion group reporting deterioration in ability to have an orgasm postoperatively. Preoperative sex life was severely hampered in the majority of patients in the entire material, but sex life underwent a marked improvement in both treatment groups by the two-year follow-up that correlated with reduction in back pain. The third study was on mobility in the lumbar spinal segments, where X-rays were taken in full extension and flexion prior to surgery and at two-year follow-up. Analysis of the films showed that 78% of the patients in the fusion group reached the surgical goal (non-mobility) and that 89% of the TDR patients maintained mobility. Preoperative disc height was lower than in a normative database in both groups, and remained lower in the fusion group, while it became higher in the TDR group. Mobility in the operated segment increased in the TDR group postoperatively. Mobility at the rest of the lumbar spine increased in both treatment groups. Mobility in adjacent segments was within the norm postoperatively, but slightly larger in the fusion group. In the fourth study the health economics of TDR vs Fusion was analysed. The hospital costs for the procedure were higher for patients in the fusion group compared to the TDR group, and the TDR patients were on sick-leave two months less. In all, these studies showed that the results in the TDR group were as good as in the fusion group. Patients are more likely to be totally pain-free when treated with TDR compared to fusion

  1. Evolution of Black Carbon Optical Properties during Atmospheric Aging: Comparison Between Theoretical Calculations and Laboratory Experiments

    NASA Astrophysics Data System (ADS)

    He, C.; Liou, K. N.; Takano, Y.; Li, Q.; Yang, P.; Zhang, R.

    2014-12-01

    The optical properties of black carbon (BC) are significantly affected by its aging process in the atmosphere. We have built a conceptual model defining three BC aging stages, including freshly emitted BC aggregates, coating by soluble material and hygroscopic growth. We apply an improved geometric-optics surface-wave approach (Liou et al., 2011; Takano et al., 2013) to calculate the absorption and scattering properties of BC at each stage and compare the theoretical results with those obtained from laboratory experiments (Zhang et al., 2008; Khalizov et al., 2009). Preliminary results show a general agreement between calculated and measured BC absorption cross sections (bias < 10%) and scattering cross sections (bias < 30%) for BC aerosols with mobility diameters of 155, 245 and 320 nm at Stages 1 and 2, where BC is coated by sulfuric acid and its water solution, respectively. We find that the calculated scattering and absorption cross sections for fresh BC aggregates (Stage 0) with different sizes are invariably larger than experimental results partly because of the uncertainty in theoretical calculations for BC with size parameters less than 1. It appears that the uncertainty in the experiment could also contribute to the discrepancy, considering that the measuring instrument missed some scattering in certain angles (0-7° and 170-180°). Finally, we will apply the conceptual model and the single-scattering results to assess the effects of BC aging processes on direct radiative forcing using observed BC vertical profiles.

  2. Changes in quantitative 3D shape features of the optic nerve head associated with age

    NASA Astrophysics Data System (ADS)

    Christopher, Mark; Tang, Li; Fingert, John H.; Scheetz, Todd E.; Abramoff, Michael D.

    2013-02-01

    Optic nerve head (ONH) structure is an important biological feature of the eye used by clinicians to diagnose and monitor progression of diseases such as glaucoma. ONH structure is commonly examined using stereo fundus imaging or optical coherence tomography. Stereo fundus imaging provides stereo views of the ONH that retain 3D information useful for characterizing structure. In order to quantify 3D ONH structure, we applied a stereo correspondence algorithm to a set of stereo fundus images. Using these quantitative 3D ONH structure measurements, eigen structures were derived using principal component analysis from stereo images of 565 subjects from the Ocular Hypertension Treatment Study (OHTS). To evaluate the usefulness of the eigen structures, we explored associations with the demographic variables age, gender, and race. Using regression analysis, the eigen structures were found to have significant (p < 0.05) associations with both age and race after Bonferroni correction. In addition, classifiers were constructed to predict the demographic variables based solely on the eigen structures. These classifiers achieved an area under receiver operating characteristic curve of 0.62 in predicting a binary age variable, 0.52 in predicting gender, and 0.67 in predicting race. The use of objective, quantitative features or eigen structures can reveal hidden relationships between ONH structure and demographics. The use of these features could similarly allow specific aspects of ONH structure to be isolated and associated with the diagnosis of glaucoma, disease progression and outcomes, and genetic factors.

  3. Optic disc boundary segmentation from diffeomorphic demons registration of monocular fundus image sequences versus 3D visualization of stereo fundus image pairs for automated early stage glaucoma assessment

    NASA Astrophysics Data System (ADS)

    Gatti, Vijay; Hill, Jason; Mitra, Sunanda; Nutter, Brian

    2014-03-01

    Despite the current availability in resource-rich regions of advanced technologies in scanning and 3-D imaging in current ophthalmology practice, world-wide screening tests for early detection and progression of glaucoma still consist of a variety of simple tools, including fundus image-based parameters such as CDR (cup to disc diameter ratio) and CAR (cup to disc area ratio), especially in resource -poor regions. Reliable automated computation of the relevant parameters from fundus image sequences requires robust non-rigid registration and segmentation techniques. Recent research work demonstrated that proper non-rigid registration of multi-view monocular fundus image sequences could result in acceptable segmentation of cup boundaries for automated computation of CAR and CDR. This research work introduces a composite diffeomorphic demons registration algorithm for segmentation of cup boundaries from a sequence of monocular images and compares the resulting CAR and CDR values with those computed manually by experts and from 3-D visualization of stereo pairs. Our preliminary results show that the automated computation of CDR and CAR from composite diffeomorphic segmentation of monocular image sequences yield values comparable with those from the other two techniques and thus may provide global healthcare with a cost-effective yet accurate tool for management of glaucoma in its early stage.

  4. Herniated Lumbar Disc

    MedlinePLUS

    ... is a herniated disc? Nonsurgical treatment Medication and pain management Surgery What can I expect after surgery? How ... program are important parts of treatment. Medication and pain management Medications used to control pain are called analgesics. ...

  5. Bryan total disc arthroplasty: a replacement disc for cervical disc disease

    PubMed Central

    Wenger, Markus; Markwalder, Thomas-Marc

    2010-01-01

    Total disc arthroplasty is a new option in the treatment of cervical degenerative disc disease. Several types of cervical disc prostheses currently challenge the gold-standard discectomy and fusion procedures. This review describes the Bryan Cervical Disc System and presents the Bryan prosthesis, its indications, surgical technique, complications, and outcomes, as given in the literature. PMID:22915917

  6. Changes in angle of optic nerve and angle of ocular orbit with increasing age in Japanese children

    PubMed Central

    Tsukitome, Hideyuki; Hatsukawa, Yoshikazu; Morimitsu, Tomoko; Yagasaki, Teiji; Kondo, Mineo

    2015-01-01

    Purpose To study changes in the opening angle of the optic nerve and the angle of the ocular orbit with increasing age in normal Japanese children. Methods We studied 147 normal children (aged 6?months to 18?years) who had undergone CT as a diagnostic procedure. Measurements were performed on axial CT images that included the entire optic nerve of both eyes. The opening angle of the optic nerve was defined as the angle formed by the intersection of a line running through the left optic nerve and a vertical line passing through the centre of the nose. The opening angle of the orbit was defined as the angle formed by the intersection of a line running tangentially along the deep lateral wall of the left orbit and a vertical line passing through the centre of the nose. The relationship between age and these opening angles was analysed by regression analysis. Results The correlation between age and opening angle of the optic nerve was not significant. In contrast, the opening angle of the orbit decreased relatively rapidly until about 2–3?years of age, and then it stabilised. The decrease in the opening angle of the orbit with increasing age was significant (p<0.001). The relationship between these two parameters was best fitted by a logarithmic regression curve. Conclusions Because the opening angle of the orbit decreased significantly with increasing age, this factor must be considered when diagnosing and treating strabismus in children. PMID:25147368

  7. Classification of wet aged related macular degeneration using optical coherence tomographic images

    NASA Astrophysics Data System (ADS)

    Haq, Anam; Mir, Fouwad Jamil; Yasin, Ubaid Ullah; Khan, Shoab A.

    2013-12-01

    Wet Age related macular degeneration (AMD) is a type of age related macular degeneration. In order to detect Wet AMD we look for Pigment Epithelium detachment (PED) and fluid filled region caused by choroidal neovascularization (CNV). This form of AMD can cause vision loss if not treated in time. In this article we have proposed an automated system for detection of Wet AMD in Optical coherence tomographic (OCT) images. The proposed system extracts PED and CNV from OCT images using segmentation and morphological operations and then detailed feature set are extracted. These features are then passed on to the classifier for classification. Finally performance measures like accuracy, sensitivity and specificity are calculated and the classifier delivering the maximum performance is selected as a comparison measure. Our system gives higher performance using SVM as compared to other methods.

  8. Optical Sensing of Polarization States Changes in Meat due to the Ageing

    NASA Astrophysics Data System (ADS)

    Tománek, Pavel; Mikláš, Jan; Abubaker, Hamed Mohamed; Grmela, Lubomír

    2010-11-01

    Food materials or biological materials display large compositional variations, inhomogeneities, and anisotropic structures. The biological tissues consist of cells which dimensions are bigger than a wavelength of visible light, therefore Mie scattering of transmitted and reflected light occurs and different polarization states arise. The meat industry needs reliable meat quality information throughout the production process in order to guarantee high-quality meat products for consumers. The minor importance is still given to the food quality control and inspection during processing operations or storing conditions. The paper presents a quite simple optical method allowing measure the freshness or ageing of products. The principle is to study temporal characteristics of polarization states of forward or backward scattered laser light in the samples in function of meat ageing.

  9. Subterranean transport and deposition of quartz by ants in sandy sites relevant to age overestimation in optical luminescence dating

    E-print Network

    Ronquist, Fredrik

    Subterranean transport and deposition of quartz by ants in sandy sites relevant to age 2012 Accepted 6 November 2012 Keywords: Optical luminescence dating OSL Quartz Age overestimation Ant of native sand and colored sand (3 parts native uncolored quartz, 1 part colored quartz) in Apalachicola

  10. Constraining the age and formation of stone runs in the Falkland Islands using Optically Stimulated Luminescence

    NASA Astrophysics Data System (ADS)

    Hansom, James D.; Evans, David J. A.; Sanderson, David C. W.; Bingham, Robert G.; Bentley, Michael J.

    2008-02-01

    The stone runs of the Falkland Islands are thought to be periglacial blockfields but their age and detailed origin remain enigmatic. We examine the fine sediments that underlie two stone runs in order to establish whether Optically Stimulated Luminescence (OSL) dating is an appropriate technique to constrain the date of emplacement of the fine sediments and, hence, the stone runs. Six samples were collected from two accessible sections during the Scotia Centenary Antarctic expedition in 2003. All samples were used to explore the main luminescence characteristics of the sediment, followed by quartz SAR dating procedures on four of the samples. Age estimates range from in excess of 54 ka to 16 ka, suggesting that the overlying stone runs remained active until 16 ka or later. Saturation of luminescence from quartz limits age estimates for the oldest samples in the sequences, however these are not critical to define the upper limit to the emplacement age for the overlying stone runs. The sediments also contain feldspars and initial results suggest that these may be useful in extending the timescale further, but require further samples to be obtained from other parts of the sequence. Extending the method to other stone runs in the Port Stanley Formation may allow estimates of the age of stabilisation of the stone runs to be extended into the 1-250 ka timescale. Luminescence dating of the underlying sediments, used in conjunction with cosmogenic isotope dating of the surface boulders from a range of locations along the stone runs, appears to offer a useful route towards decoding the depositional history of these impressive deposits.

  11. Intervertebral disc degeneration.

    PubMed

    Fraser, R D; Osti, O L; Vernon-Roberts, B

    1993-03-01

    Disc degeneration in the human spine is a complex phenomenon characterised by biochemical change in the nucleus pulposus and inner annulus and the formation of clefts and fissures radiating from the central area of the disc towards the periphery. In addition, and probably independent of these phenomena, discrete defects in the outer annular attachement are seen which are likely to be due to mechanical stress and failure. The presence of stress tears in disc tissue and their failure to heal can initiate or accelerate the degeneration of the central component of the intervertebral disc. We postulate that discogenic pain may be linked to damage to the outer portion of the annulus fibrosus. Although it would seem logical to assume that discs with sustained high intradiscal pressure would be more prone to pain referred in the outer annular layers because of higher tensile strain, analysis of prospective studies has failed to confirm a relationship between typical pain reproduction at discography and high pressure values. It is concluded that, at present, the only consistent morphological changes present in patients with pain reproduction at discography are the presence of various annular defects involving the outer layers. Whether nerve ingrowth during attempts at repair of these defects is a consistent feature remains to be established. PMID:20054919

  12. Neurovascular coupling in normal aging: A combined optical, ERP and fMRI study

    PubMed Central

    Fabiani, Monica; Gordon, Brian A.; Maclin, Edward L.; Pearson, Melanie A.; Brumback-Peltz, Carrie R.; Low, Kathy A.; McAuley, Edward; Sutton, Bradley P.; Kramer, Arthur F.; Gratton, Gabriele

    2013-01-01

    Brain aging is characterized by changes in both hemodynamic and neuronal responses, which may be influenced by the cardiorespiratory fitness of the individual. To investigate the relationship between neuronal and hemodynamic changes, we studied the brain activity elicited by visual stimulation (checkerboard reversals at different frequencies) in younger adults and in older adults varying in physical fitness. Four functional brain measures were used to compare neuronal and hemodynamic responses obtained from BA17: two reflecting neuronal activity (the event-related optical signal, EROS, and the C1 response of the ERP), and two reflecting functional hemodynamic changes (functional magnetic resonance imaging, fMRI, and near-infrared spectroscopy, NIRS). The results indicated that both younger and older adults exhibited a quadratic relationship between neuronal and hemodynamic effects, with reduced increases of the hemodynamic response at high levels of neuronal activity. Although older adults showed reduced activation, similar neurovascular coupling functions were observed in the two age groups when fMRI and deoxy-hemoglobin measures were used. However, the coupling between oxy-and deoxy-hemoglobin changes decreased with age and increased with increasing fitness. These data indicate that departures from linearity in neurovascular coupling may be present when using hemodynamic measures to study neuronal function. PMID:23664952

  13. Impact of Age on Stent Strut Coverage and Neointimal Remodeling as Assessed by Optical Coherence Tomography.

    PubMed

    Han, Zhigang; Feng, Linxing; Du, Hongwei; Sun, Zhao; Hu, Sining; Dai, Jiannan; Sun, Meng; Xing, Lei; Hou, Jingbo; Zhang, Shaosong; Yu, Bo

    2015-12-01

    While older age associates with adverse percutaneous coronary intervention (PCI) outcomes, detailed information relating age to stent strut coverage and neointimal characteristics is lacking.One hundred nineteen patients with 123 sirolimus-eluting stents (SESs) were divided into 3 groups: group A (?55 years), group B (56-65 years), and group C (>65 years). At 6 and 12 months of follow-up, optical coherence tomography was performed to assess strut coverage and neointimal remodeling.At 6 months, the proportion of uncovered struts increased with age: 6.1% in group A versus 7.3% in group B versus 11.7% in group C (P?age (3.9% vs. 3.3% vs. 4.9 %; P?

  14. Modeling the Compact Disc Read System in Lab

    ERIC Educational Resources Information Center

    Hinaus, Brad; Veum, Mick

    2009-01-01

    One of the great, engaging aspects of physics is its application to everyday technology. The compact disc player is an example of one such technology that applies fundamental principles from optics in order to efficiently store and quickly retrieve information. We have created a lab in which students use simple optical components to assemble a…

  15. Revival of the Jumping Disc

    ERIC Educational Resources Information Center

    Ucke, C.; Schlichting, H-J.

    2009-01-01

    Snap discs made of bimetal have many technical applications as thermostats. Jumping discs are a toy version of such snap discs. Besides giving technical information, we describe physical investigations. We show especially how, through simple measurements and calculations, you can determine the initial speed ([approximately equal to]3.5 m…

  16. The DISC Quotient

    NASA Astrophysics Data System (ADS)

    Elliott, John R.; Baxter, Stephen

    2012-09-01

    D.I.S.C: Decipherment Impact of a Signal's Content. The authors present a numerical method to characterise the significance of the receipt of a complex and potentially decipherable signal from extraterrestrial intelligence (ETI). The purpose of the scale is to facilitate the public communication of work on any such claimed signal, as such work proceeds, and to assist in its discussion and interpretation. Building on a "position" paper rationale, this paper looks at the DISC quotient proposed and develops the algorithmic steps and comprising measures that form this post detection strategy for information dissemination, based on prior work on message detection, decipherment. As argued, we require a robust and incremental strategy, to disseminate timely, accurate and meaningful information, to the scientific community and the general public, in the event we receive an "alien" signal that displays decipherable information. This post-detection strategy is to serve as a stepwise algorithm for a logical approach to information extraction and a vehicle for sequential information dissemination, to manage societal impact. The "DISC Quotient", which is based on signal analysis processing stages, includes factors based on the signal's data quantity, structure, affinity to known human languages, and likely decipherment times. Comparisons with human and other phenomena are included as a guide to assessing likely societal impact. It is submitted that the development, refinement and implementation of DISC as an integral strategy, during the complex processes involved in post detection and decipherment, is essential if we wish to minimize disruption and optimize dissemination.

  17. The Teddy Bears' Disc.

    ERIC Educational Resources Information Center

    Laurillard, Diana

    1985-01-01

    Reports an evaluation of the Teddy Bear disc, an interactive videodisc developed at the Open University for a second-level course in metallurgy and materials technology. Findings from observation of students utilizing the videodisc are reviewed; successful design features and design problems are considered; and development costs are outlined. (MBR)

  18. Infrared variability from circumbinary disc temperature modulations

    NASA Astrophysics Data System (ADS)

    Bodman, Eva H. L.; Quillen, Alice

    2015-11-01

    The temperature of a circumbinary disc edge should undulate due to variations in illumination as a function of binary orbital phase. We explore circumbinary disc temperature variations as a source of broad-band infrared light-curve variability. Approximating the wall of a circumbinary disc edge as a wide optically thick cylinder with surface temperature dependent on its illumination, we find that a binary composed of 1 and 0.5 M? pre-main-sequence stars in a ˜15.5 d period, would exhibit the largest amplitude variations of ˜9 per cent at 3.77 and 4.68 ?m as seen by a distant observer. The amplitude of variations and shape of the light curve are sensitive to the luminosity and mass ratios of the stars in the binary, the radius of the circumbinary disc clearing, the binary separation, and the orbital inclination. The light-curve variations are smooth and very red with a non-sinusoidal shape for most of the parameter space explored. Possible morphologies include a single peak with a flat region, two peaks of different heights, or a single dip.

  19. Testing the molecular-hydrogen Kennicutt-Schmidt law in the low-density environments of extended ultraviolet disc galaxies

    NASA Astrophysics Data System (ADS)

    Watson, Linda C.; Martini, Paul; Lisenfeld, Ute; Böker, Torsten; Schinnerer, Eva

    2016-01-01

    Studying star formation beyond the optical radius of galaxies allows us to test empirical relations in extreme conditions with low average gas density and low molecular fraction. Previous studies discovered galaxies with extended ultraviolet (XUV) discs, which often contain star-forming regions with lower H?-to-far-UV (FUV) flux ratios compared to inner disc star-forming regions. However, most previous studies lack measurements of molecular gas, which is presumably the component of the interstellar medium out of which stars form. We analysed published CO measurements and upper limits for 15 star-forming regions in the XUV or outer disc of three nearby spiral galaxies and a new CO upper limit from the IRAM (Institut de Radioastronomie Millimétrique) 30 m telescope in one star-forming region at r = 3.4r25 in the XUV disc of NGC 4625. We found that the star-forming regions are in general consistent with the same molecular-hydrogen Kennicutt-Schmidt law that applies within the optical radius, independent of whether we used H? or FUV as the star formation rate (SFR) tracer. However, a number of the CO detections are significantly offset towards higher SFR surface density for their molecular-hydrogen surface density. Deeper CO data may enable us to use the presence or absence of molecular gas as an evolutionary probe to break the degeneracy between age and stochastic sampling of the initial mass function as the explanation for the low H?-to-FUV flux ratios in XUV discs.

  20. Characterization of Choroidal Layers in Normal Aging Eyes Using Enface Swept-Source Optical Coherence Tomography

    PubMed Central

    Mullins, Robert F.; Baumal, Caroline R.; Mohler, Kathrin J.; Kraus, Martin F.; Liu, Jonathan; Badaro, Emmerson; Alasil, Tarek; Hornegger, Joachim; Fujimoto, James G.; Duker, Jay S.; Waheed, Nadia K.

    2015-01-01

    Purpose To characterize qualitative and quantitative features of the choroid in normal eyes using enface swept-source optical coherence tomography (SS-OCT). Methods Fifty-two eyes of 26 consecutive normal subjects were prospectively recruited to obtain multiple three-dimensional 12x12mm volumetric scans using a long-wavelength high-speed SS-OCT prototype. A motion-correction algorithm merged multiple SS-OCT volumes to improve signal. Retinal pigment epithelium (RPE) was segmented as the reference and enface images were extracted at varying depths every 4.13?m intervals. Systematic analysis of the choroid at different depths was performed to qualitatively assess the morphology of the choroid and quantify the absolute thicknesses as well as the relative thicknesses of the choroidal vascular layers including the choroidal microvasculature (choriocapillaris, terminal arterioles and venules; CC) and choroidal vessels (CV) with respect to the subfoveal total choroidal thickness (TC). Subjects were divided into two age groups: younger (<40 years) and older (?40 years). Results Mean age of subjects was 41.92 (24-66) years. Enface images at the level of the RPE, CC, CV, and choroidal-scleral interface were used to assess specific qualitative features. In the younger age group, the mean absolute thicknesses were: TC 379.4?m (SD±75.7?m), CC 81.3?m (SD±21.2?m) and CV 298.1?m (SD±63.7?m). In the older group, the mean absolute thicknesses were: TC 305.0?m (SD±50.9?m), CC 56.4?m (SD±12.1?m) and CV 248.6?m (SD±49.7?m). In the younger group, the relative thicknesses of the individual choroidal layers were: CC 21.5% (SD±4.0%) and CV 78.4% (SD±4.0%). In the older group, the relative thicknesses were: CC 18.9% (SD±4.5%) and CV 81.1% (SD±4.5%). The absolute thicknesses were smaller in the older age group for all choroidal layers (TC p=0.006, CC p=0.0003, CV p=0.03) while the relative thickness was smaller only for the CC (p=0.04). Conclusions Enface SS-OCT at 1050nm enables a precise qualitative and quantitative characterization of the individual choroidal layers in normal eyes. Only the CC is relatively thinner in the older eyes. In-vivo evaluation of the choroid at variable depths may be potentially valuable in understanding the natural history of age-related posterior segment disease. PMID:26172550

  1. Two-level total lumbar disc replacement

    PubMed Central

    Bakaloudis, Georgios; Lolli, Francesco; Vommaro, Francesco; Parisini, Patrizio

    2009-01-01

    Total lumbar disc replacement (TDR) has been widely used as a treatment option for 2-level symptomatic degenerative disc disease. However, recent studies have presented conflicting results and some authors concluded that outcome deteriorated when disc replacement was performed bisegmentally, with an increase of complications for bisegmental replacements in comparison with monosegmental disc arthroplasty. The goal of the present retrospective study is to investigate results in a group of patients who have received bisegmental TDR with SB Charitè III artificial disc for degenerative disc disease with a minimum follow-up of 3 years, and to compare the results of 2-level disc replacement versus 1-level patients treated with the same prosthesis. A total of 32 patients had at least 3-years follow-up and were reviewed. The average age of the patients was 38.5 years. There were 11 males and 21 females. About 16 patients received 2-level TDR (SB Charitè III) and 16 received 1-level TDR (SB Charitè III). Both radiographic and functional outcome analysis, including patient’s satisfaction, was performed. There were no signs of degenerative changes of the adjacent segments in any case of the 2- or 1-level TDR. There was no statistically significant difference between 2- and 1-level TDR both at 12 months and at 3-years follow-up on functional outcome scores. There was a statistically insignificant difference concerning the patients satisfaction between 1- and 2-level surgeries at the last follow-up (P = 0.46). In the 2-level TDR patients, there were 5 minor complications (31.25%), whereas major complications occurred in 4 more patients (25%) and required a new surgery in 2 cases (12.5%). In the 1-level cases there were 2 minor complications (12.5%) and 2 major complications (12.5%) and a new revision surgery was required in 1 patient (6.25%). In conclusion, the use of 2-level disc replacement at last follow-up presented a higher incidence of complications than in cases with 1-level replacement. At the same time it was impossible to delineate a clear difference in evaluating the questionnaires between the follow-up results of patients receiving 2- and 1-level TDR: the 2-level group presented slightly lower scores at follow-up, but none was statistically significant. PMID:19399536

  2. Warp Propagation in Astrophysical Discs

    NASA Astrophysics Data System (ADS)

    Nixon, Chris; King, Andrew

    Astrophysical discs are often warped, that is, their orbital planes change with radius. This occurs whenever there is a non-axisymmetric force acting on the disc, for example the Lense-Thirring precession induced by a misaligned spinning black hole, or the gravitational pull of a misaligned companion. Such misalignments appear to be generic in astrophysics. The wide range of systems that can harbour warped discs—protostars, X-ray binaries, tidal disruption events, quasars and others—allows for a rich variety in the disc's response. Here we review the basic physics of warped discs and its implications.

  3. Warp propagation in astrophysical discs

    E-print Network

    Nixon, Chris

    2015-01-01

    Astrophysical discs are often warped, that is, their orbital planes change with radius. This occurs whenever there is a non-axisymmetric force acting on the disc, for example the Lense-Thirring precession induced by a misaligned spinning black hole, or the gravitational pull of a misaligned companion. Such misalignments appear to be generic in astrophysics. The wide range of systems that can harbour warped discs - protostars, X-ray binaries, tidal disruption events, quasars and others - allows for a rich variety in the disc's response. Here we review the basic physics of warped discs and its implications.

  4. Gas Modelling in the Disc of HD 163296

    NASA Technical Reports Server (NTRS)

    Tilling, I.; Woitke, P.; Meeus, G.; Mora, A.; Montesinos, B.; Riviere-Marichalar, P.; Eiroa, C.; Thi, W. -F.; Isella, A.; Roberge, A.; Martin-Zaidi, C.; Kamp, I.; Pinte, C.; Sandell, G.; Vacca, W. D.; Menard, F.; Mendigutia, I.; Duchene, G.; Dent, W. R. F.; Aresu, G.; Meijerink, R.; Spaans, M.

    2011-01-01

    We present detailed model fits to observations of the disc around the Herbig Ae star HD 163296. This well-studied object has an age of approx. 4Myr, with evidence of a circumstellar disc extending out to approx. 540AU. We use the radiation thermo-chemical disc code ProDiMo to model the gas and dust in the circumstellar disc of HD 163296, and attempt to determine the disc properties by fitting to observational line and continuum data. These include new Herschel/PACS observations obtained as part of the open-time key program GASPS (Gas in Protoplanetary Systems), consisting of a detection of the [Oi] 63 m line and upper limits for several other far infrared lines. We complement this with continuum data and ground-based observations of the CO-12 3-2, 2-1 and CO-13 J=1-0 line transitions, as well as the H2 S(1) transition. We explore the effects of stellar ultraviolet variability and dust settling on the line emission, and on the derived disc properties. Our fitting efforts lead to derived gas/dust ratios in the range 9-100, depending on the assumptions made. We note that the line fluxes are sensitive in general to the degree of dust settling in the disc, with an increase in line flux for settled models. This is most pronounced in lines which are formed in the warm gas in the inner disc, but the low excitation molecular lines are also affected. This has serious implications for attempts to derive the disc gas mass from line observations. We derive fractional PAH abundances between 0.007 and 0.04 relative to ISM levels. Using a stellar and UV excess input spectrum based on a detailed analysis of observations, we find that the all observations are consistent with the previously assumed disc geometry

  5. Spiral density waves in the outer galactic gaseous discs

    NASA Astrophysics Data System (ADS)

    Khoperskov, S. A.; Bertin, G.

    2015-08-01

    Deep H I observations of the outer parts of disc galaxies demonstrate the frequent presence of extended, well-developed spiral arms far beyond the optical radius. To understand the nature and the origin of such outer spiral structure, we investigate the propagation in the outer gaseous disc of large-scale spiral waves excited in the bright optical disc. Using hydrodynamical simulations, we show that non-axisymmetric density waves, penetrating in the gas through the outer Lindblad resonance, can exhibit relatively regular spiral structures outside the bright optical stellar disc. For low-amplitude structures, the results of numerical simulations match the predictions of a simple WKB linear theory. The amplitude of spiral structure increases rapidly with radius. Beyond ?2 optical radii, spirals become non-linear (the linear theory becomes quantitatively and qualitatively inadequate) and unstable. In numerical simulations, in models for which gas is available very far out, spiral arms can extend out to 25 disc scalelengths. A comparison between the properties of the models we have investigated and the observed properties of individual galaxies may shed light into the problem of the amount and distribution of dark matter in the outer halo.

  6. Disc resonator gyroscope fabrication process requiring no bonding alignment

    NASA Technical Reports Server (NTRS)

    Shcheglov, Kirill V. (Inventor)

    2010-01-01

    A method of fabricating a resonant vibratory sensor, such as a disc resonator gyro. A silicon baseplate wafer for a disc resonator gyro is provided with one or more locating marks. The disc resonator gyro is fabricated by bonding a blank resonator wafer, such as an SOI wafer, to the fabricated baseplate, and fabricating the resonator structure according to a pattern based at least in part upon the location of the at least one locating mark of the fabricated baseplate. MEMS-based processing is used for the fabrication processing. In some embodiments, the locating mark is visualized using optical and/or infrared viewing methods. A disc resonator gyroscope manufactured according to these methods is described.

  7. Biomechanics of Disc Degeneration

    PubMed Central

    Palepu, V.; Kodigudla, M.; Goel, V. K.

    2012-01-01

    Disc degeneration and associated disorders are among the most debated topics in the orthopedic literature over the past few decades. These may be attributed to interrelated mechanical, biochemical, and environmental factors. The treatment options vary from conservative approaches to surgery, depending on the severity of degeneration and response to conservative therapies. Spinal fusion is considered to be the “gold standard” in surgical methods till date. However, the association of adjacent level degeneration has led to the evolution of motion preservation technologies like spinal arthroplasty and posterior dynamic stabilization systems. These new technologies are aimed to address pain and preserve motion while maintaining a proper load sharing among various spinal elements. This paper provides an elaborative biomechanical review of the technologies aimed to address the disc degeneration and reiterates the point that biomechanical efficacy followed by long-term clinical success will allow these nonfusion technologies as alternatives to fusion, at least in certain patient population. PMID:22745914

  8. Mechanotransduction in intervertebral discs

    PubMed Central

    Tsai, Tsung-Ting; Cheng, Chao-Min; Chen, Chien-Fu; Lai, Po-Liang

    2014-01-01

    Mechanotransduction plays a critical role in intracellular functioning—it allows cells to translate external physical forces into internal biochemical activities, thereby affecting processes ranging from proliferation and apoptosis to gene expression and protein synthesis in a complex web of interactions and reactions. Accordingly, aberrant mechanotransduction can either lead to, or be a result of, a variety of diseases or degenerative states. In this review, we provide an overview of mechanotransduction in the context of intervertebral discs, with a focus on the latest methods of investigating mechanotransduction and the most recent findings regarding the means and effects of mechanotransduction in healthy and degenerative discs. We also provide some discussion of potential directions for future research and treatments. PMID:25267492

  9. First results of the SONS survey: submillimetre detections of debris discs

    NASA Astrophysics Data System (ADS)

    Pani?, O.; Holland, W. S.; Wyatt, M. C.; Kennedy, G. M.; Matthews, B. C.; Lestrade, J. F.; Sibthorpe, B.; Greaves, J. S.; Marshall, J. P.; Phillips, N. M.; Tottle, J.

    2013-10-01

    New detections of debris discs at submillimetre wavelengths present highly valuable complementary information to prior observations of these sources at shorter wavelengths. Characterization of discs through spectral energy distribution modelling including the submillimetre fluxes is essential for our basic understanding of disc mass and temperature, and presents a starting point for further studies using millimetre interferometric observations. In the framework of the ongoing SCUBA-2 Observations of Nearby Stars, the instrument SCUBA-2 on the James Clerk Maxwell Telescope was used to provide measurements of 450 and 850 ?m fluxes towards a large sample of nearby main-sequence stars with debris discs detected previously at shorter wavelengths. We present the first results from the ongoing survey, concerning 850 ?m detections and 450 ?m upper limits towards 10 stars, the majority of which are detected at submillimetre wavelengths for the first time. One, or possibly two, of these new detections is likely a background source. We fit the spectral energy distributions of the star+disc systems with a blackbody emission approach and derive characteristic disc temperatures. We use these temperatures to convert the observed fluxes to disc masses. We obtain a range of disc masses from 0.001 to 0.1 M?, values similar to the prior dust mass measurements towards debris discs. There is no evidence for evolution in dust mass with age on the main sequence, and indeed the upper envelope remains relatively flat at ?0.5 M? at all ages. The inferred disc masses are lower than those from disc detections around pre-main-sequence stars, which may indicate a depletion of solid mass. This may also be due to a change in disc opacity, though limited sensitivity means that it is not yet known what fraction of pre-main-sequence stars have discs with dust masses similar to debris disc levels. New, high-sensitivity detections are a path towards investigating the trends in dust mass evolution.

  10. Beyond the standard accretion disc model: coupled magnetic disc--corona solutions with a physically motivated viscosity law

    E-print Network

    A. Merloni

    2003-02-05

    We present a systematic, analytical study of geometrically thin, optically thick accretion disc solutions for magnetized turbulent flows, with an alpha-like viscosity prescription. Under the only assumptions that (1) Magneto-Rotational instability (MRI) generates the turbulence that produces the anomalous viscosity needed for accretion to proceed, and that (2) the magnetic field amplified by the instability saturates due to buoyant vertical escape, we are able to self-consistently solve the disc structure equations including the fraction of power, f, that is carried off by vertical Poynting flux (and likely dissipated outside the optically thick disc). For low-viscosity discs, we obtain stable high-f solutions at low accretion rates, when gas pressure dominates, and unstable, low-f, radiation pressure dominated solutions at high accretion rates. For high viscosity discs, instead, a new thermally and viscously stable, radiation pressure dominated solution is found, characterized by f~1 and appearing only above a critical accretion rate (of the order of few tenths of the Eddington one). We discuss the regimes of validity of our assumptions, and the astrophysical relevance of our solutions. We conclude that our newly discovered thin disc solutions, possibly accompanied by powerful, magnetically dominated coronae and outflows, should be seriously considered as models for black holes accreting at super-Eddington rates.

  11. Apsidal precession, disc breaking and viscosity in warped discs

    NASA Astrophysics Data System (ADS)

    Nealon, Rebecca; Nixon, Chris; Price, Daniel J.; King, Andrew

    2016-01-01

    We demonstrate the importance of general relativistic apsidal precession in warped black hole accretion discs by comparing three-dimensional smoothed particle hydrodynamic simulations in which this effect is first neglected, and then included. If apsidal precession is neglected, we confirm the results of an earlier magnetohydrodynamic simulation which made this assumption, showing that at least in this case the ? viscosity model produces very similar results to those of simulations where angular momentum transport is due to the magnetorotational instability. Including apsidal precession significantly changes the predicted disc evolution. For moderately inclined discs thick enough that tilt is transported by bending waves, we find a disc tilt which is non-zero at the inner disc edge and oscillates with radius, consistent with published analytic results. For larger inclinations, we find disc breaking.

  12. Apsidal precession, disc breaking and viscosity in warped discs

    E-print Network

    Nealon, Rebecca; Price, Daniel J; King, Andrew

    2015-01-01

    We demonstrate the importance of general relativistic apsidal precession in warped black hole accretion discs by comparing three - dimensional smoothed particle hydrodynamic simulations in which this effect is first neglected, and then included. If apsidal precession is neglected, we confirm the results of an earlier magnetohydrodynamic simulation which made this assumption, showing that at least in this case the $\\alpha$ viscosity model produces very similar results to those of simulations where angular momentum transport is due to the magnetorotational instability. Including apsidal precession significantly changes the predicted disc evolution. For moderately inclined discs thick enough that tilt is transported by bending waves, we find a disc tilt which is nonzero at the inner disc edge and oscillates with radius, consistent with published analytic results. For larger inclinations we find disc breaking.

  13. Size distributions of dust in circumstellar debris discs

    NASA Astrophysics Data System (ADS)

    Krivov, A. V.; Mann, I.; Krivova, N. A.

    2000-10-01

    The size distribution of particles in a dust disc is determined by, and holds the key to, sources, sinks and dynamics of grains. Here we derive the size distribution in circumstellar debris discs, exemplified by the disc of begin {equation}ta Pictoris, by modelling the dynamical evolution of the circumstellar dust, dominated by collisions. The whole disc is considered as consisting of two dust populations: larger grains moving in bound orbits (alpha -meteoroids) and smaller ones blown away by radiation pressure (begin {equation}ta-meteoroids). Although begin {equation}ta-meteoroids leave the disc in hyperbolic trajectories, they are continuously replenished by collisions, so that at any time the disc contains a substantial population of small particles. As a consequence, the fragmentation of alpha -meteoroids not only by mutual collisions, but also by impacts of begin {equation}ta-meteoroids becomes significant. This flattens the distribution of alpha -meteoroids in the size regime adjacent to the blow-out limit and shifts the cross section-dominating sizes from a few micrometres to ga 10 mum . The overall distribution shows essentially three different slopes: steeper ones for both begin {equation}ta-meteoroids and large alpha -meteoroids and a gentler one for alpha -meteoroids with sizes just above the blow-out limit. This resembles the size distribution of interplanetary dust particles in the Solar system which, however, is shaped by different mechanisms. The basic features of the modelled size distribution (the presence of a substantial population of small hyperbolic particles in the disc, the dominance of grains ~ 10 mum in size) well agree with the observational data available. Although particular calculations were made for the begin {equation}ta Pic disc, our basic qualitative conclusions directly apply to the debris discs around other Vega-type stars with low gas contents and similar or somewhat lower optical depths.

  14. Optical coherence tomography-based intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration.

    PubMed

    Ernst, Benjamin J; Barkmeier, Andrew J; Akduman, Levent

    2010-06-01

    To evaluate optical coherence tomography (OCT)-based intravitreal ranibizumab treatment for neovascular age-related macular degeneration (AMD), the charts of consecutive patients who received intravitreal ranibizumab for subfoveal choroidal neovascularization due to AMD were retrospectively reviewed. Patients with less than 6 months follow-up were excluded. OCT was performed at baseline and at monthly intervals for induction therapy. Injections were given monthly until no improvement was observed between successive OCTs. In the maintenance period, reinjections were performed for any recurrence of macular fluid on OCT. Main outcome measures were visual acuity and number of injections given. Twenty-five eyes of 22 patients with mean follow-up of 16 months [standard deviation (SD) = 3.7 months] had mean improvement of 1.6 lines of Snellen visual acuity (SD 2.9, 95% confidence interval 0.48-2.9, P = 0.008). Visual acuity was stable (< or =3 lines of visual acuity lost) in 22 eyes (88%). Nine eyes (36%) gained > or =3 lines. Three eyes (12%) lost > or =3 lines. A mean of 6.0 (SD 2.7) injections were given over a follow-up period ranging from 8 to 21 months. We conclude that OCT-based intravitreal ranibizumab treatment for neovascular AMD offered excellent visual acuity results and reduced the number of injections compared with monthly dosing. PMID:19730802

  15. Enclosed rotary disc air pulser

    DOEpatents

    Olson, A. L. (Idaho Falls, ID); Batcheller, Tom A. (Idaho Falls, ID); Rindfleisch, J. A. (Arco, ID); Morgan, John M. (Arco, ID)

    1989-01-01

    An enclosed rotary disc air pulser for use with a solvent extraction pulse olumn includes a housing having inlet, exhaust and pulse leg ports, a shaft mounted in the housing and adapted for axial rotation therein, first and second disc members secured to the shaft within the housing in spaced relation to each other to define a chamber therebetween, the chamber being in communication with the pulse leg port, the first disc member located adjacent the inlet port, the second disc member being located adjacent the exhaust port, each disc member having a milled out portion, the disc members positioned on the shaft so that as the shaft rotates, the milled out portions permit alternative cyclical communication between the inlet port and the chamber and the exhaust port and the chamber.

  16. OPTICAL COHERENCE TOMOGRAPHY–BASED CORRELATION BETWEEN CHOROIDAL THICKNESS AND DRUSEN LOAD IN DRY AGE-RELATED MACULAR DEGENERATION

    PubMed Central

    KO, ASHLEY; CAO, SIJIA; PAKZAD-VAEZI, KAIVON; BRASHER, PENELOPE M.; MERKUR, ANDREW B.; ALBIANI, DAVID A.; KIRKER, ANDREW W.; CUI, JING; MATSUBARA, JOANNE; FOROOGHIAN, FARZIN

    2014-01-01

    Purpose Spectral domain optical coherence tomography can be used to measure both choroidal thickness and drusen load. The authors conducted an exploratory study using spectral domain optical coherence tomography to determine if a correlation between choroidal thickness and drusen load exists in patients with dry age-related macular degeneration. Methods Forty-four patients with dry age-related macular degeneration were recruited. The drusen area and volume were determined using the automated software algorithm of the spectral domain optical coherence tomography device, and choroidal thickness was measured using enhanced depth imaging. Correlations were determined using multivariable and univariable analyses. Results The authors found an inverse correlation between choroidal thickness and drusen load (r = ?0.35, P = 0.04). Drusen load was also correlated with visual acuity (r = 0.32, P = 0.04). A correlation between choroidal thickness and visual acuity was suggested (r = ?0.22, P = 0.21). Conclusion Spectral domain optical coherence tomography can be used to assess the correlation between drusen load and choroidal thickness, both of which show a relationship with visual acuity. The measurement of these outcomes may serve as important outcome parameters in routine clinical care and in clinical trials for patients with dry age-related macular degeneration. PMID:23474546

  17. Inflammation in intervertebral disc degeneration and regeneration

    PubMed Central

    Molinos, Maria; Almeida, Catarina R.; Caldeira, Joana; Cunha, Carla; Gonçalves, Raquel M.; Barbosa, Mário A.

    2015-01-01

    Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a problem with a heavy economic burden, which has been increasing in prevalence as populations age. Deeper knowledge of the complex spatial and temporal orchestration of cellular interactions and extracellular matrix remodelling is critical to improve current IVD therapies, which have so far proved unsatisfactory. Inflammation has been correlated with degenerative disc disease but its role in discogenic pain and hernia regression remains controversial. The inflammatory response may be involved in the onset of disease, but it is also crucial in maintaining tissue homeostasis. Furthermore, if properly balanced it may contribute to tissue repair/regeneration as has already been demonstrated in other tissues. In this review, we focus on how inflammation has been associated with IVD degeneration by describing observational and in vitro studies as well as in vivo animal models. Finally, we provide an overview of IVD regenerative therapies that target key inflammatory players. PMID:25673296

  18. Numbered nasal discs for waterfowl

    USGS Publications Warehouse

    Bartonek, J.C.; Dane, C.W.

    1964-01-01

    Numbered nasal discs were successfully used in studies requiring large numbers of individually marked waterfowl. The procedure for constructing these discs is outlined. Blue-winged teal (Anas discors) with 5/8-inch discs, and canvasback (Aythya valisineria) and redhead (A. americana) with 3/4-inch discs can be individually identified up to 50 and 80 yards, respectively, with a gunstock-mounted, 20-power spotting scope. The particular value of these markers is their durability, the number of combinations possible, and the apparent absence of behavioral or mortality influence among such species as the blue-winged teal.

  19. Two-photon excitation spectroscopy of coupled asymmetric GaN/AlGaN quantum discs

    NASA Astrophysics Data System (ADS)

    Lee, K. H.; Birner, S.; Na, J. H.; Taylor, R. A.; Yi, S. N.; Park, Y. S.; Park, C. M.; Kang, T. W.

    2006-12-01

    By using two-photon excitation spectroscopy we take advantage of the increased spatial resolution to perform time-integrated and time-resolved photoluminescence measurements on several discrete stacks of GaN quantum discs. The stack structure consisted of coupled asymmetric GaN quantum discs with embedded AlGaN barriers, which were grown at the tip of a GaN nanocolumn. We observed that with increasing optical excitation power the carrier lifetime decreased due to free-carrier screening, with an enhancement of the screening effect in the larger quantum disc due to carrier tunnelling from the smaller quantum disc.

  20. The prevalence of disc degeneration associated with neural arch defects of the lumbar spine assessed by magnetic resonance imaging.

    PubMed

    Szypryt, E P; Twining, P; Mulholland, R C; Worthington, B S

    1989-09-01

    The morphology of the intervertebral discs in 40 patients with spondylolytic and mild spondylolisthetic defects of the lumbar spine were assessed using magnetic resonance imaging. The results were compared with an age- and sex-matched asymptomatic population, and the difference in prevalence of disc degeneration between the two groups was noted. Under the age of 25 years, degeneration was uncommon in both the disc associated with the neural arch defect and the comparable disc in the control population. However, after this age, the prevalence of the disc degeneration rose in both groups, but was more marked in the spondylytic group, and this difference was statistically significant (P = 0.025). The results suggest that a neural arch defect is associated with an increased prevalence of disc degeneration, which is greater than is seen in a normal aging population. PMID:2789436

  1. Preparation of ormetoprim sulfadimethoxine medicated discs for disc diffusion assay

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Romet (a blend of ormetoprim and sulfadimethoxine) is a typeA medicated article for the manufacture of medicated feed in the catfish industry. Recently, the commercial manufacture of ormetoprim–sulfadimethoxine susceptibility discs was discontinued. Ormetoprim–sulfadimethoxine discs were prepared at...

  2. Optical and Near-Infrared Color Profiles in Nearby Early-Type Galaxies and The Implied Age and Metallicity Gradients

    E-print Network

    Hong Wu; Zhengyi Shao; H. J. Mo; Xiaoyang Xia; Zugan Deng

    2004-12-02

    We present results of age and metallicity gradient analysis inferred from both optical and near-infrared surface photometry. The analysis is based on a sample of 36 nearby early-type galaxies, obtained from the Early Data Release of the Sloan Digital Sky Survey and the Two Micron All Sky Survey. Surface brightness profiles were derived in each band, and used to study the color gradients of the galaxies. Using simple stellar population models with both optical and near infrared colors, we may interpret the color gradients in term of age and metallicity gradients of galaxies. Using $g_Z \\equiv d \\log Z_{\\rm met} / d \\log R $ and $g_A = d \\log {\\rm Age} / d \\log R $ to represent the metallicity and age gradients, we found a median value of $g_Z=-0.25\\pm 0.03$ for the metallicity gradient, with a dispersion $\\sigma_{g_Z}=0.19\\pm0.02$. The corresponding values for the age gradient were $g_A=0.02\\pm 0.04$ and $\\sigma_{g_A}=0.25\\pm0.03$. These results are in good agreement with recent observational results, as well as with recent simulations that suggest both monolithic collapse and major merger have played important roles in the formation of early-type galaxies. Our results demonstrate the potential of using multi-waveband colors obtained from current and future optical and infrared surveys in constraining the age and metallicity gradients of early-type galaxies.

  3. Galaxy Zoo: CANDELS barred discs and bar fractions

    NASA Astrophysics Data System (ADS)

    Simmons, B. D.; Melvin, Thomas; Lintott, Chris; Masters, Karen L.; Willett, Kyle W.; Keel, William C.; Smethurst, R. J.; Cheung, Edmond; Nichol, Robert C.; Schawinski, Kevin; Rutkowski, Michael; Kartaltepe, Jeyhan S.; Bell, Eric F.; Casteels, Kevin R. V.; Conselice, Christopher J.; Almaini, Omar; Ferguson, Henry C.; Fortson, Lucy; Hartley, William; Kocevski, Dale; Koekemoer, Anton M.; McIntosh, Daniel H.; Mortlock, Alice; Newman, Jeffrey A.; Ownsworth, Jamie; Bamford, Steven; Dahlen, Tomas; Faber, Sandra M.; Finkelstein, Steven L.; Fontana, Adriano; Galametz, Audrey; Grogin, N. A.; Grützbauch, Ruth; Guo, Yicheng; Häußler, Boris; Jek, Kian J.; Kaviraj, Sugata; Lucas, Ray A.; Peth, Michael; Salvato, Mara; Wiklind, Tommy; Wuyts, Stijn

    2014-12-01

    The formation of bars in disc galaxies is a tracer of the dynamical maturity of the population. Previous studies have found that the incidence of bars in discs decreases from the local Universe to z ˜ 1, and by z > 1 simulations predict that bar features in dynamically mature discs should be extremely rare. Here, we report the discovery of strong barred structures in massive disc galaxies at z ˜ 1.5 in deep rest-frame optical images from the Cosmic Assembly Near-Infrared Deep Extragalactic Legacy Survey. From within a sample of 876 disc galaxies identified by visual classification in Galaxy Zoo, we identify 123 barred galaxies. Selecting a subsample within the same region of the evolving galaxy luminosity function (brighter than L*), we find that the bar fraction across the redshift range 0.5 ? z ? 2 ( f_{bar} = 10.7^{+6.3}_{-3.5} per cent after correcting for incompleteness) does not significantly evolve. We discuss the implications of this discovery in the context of existing simulations and our current understanding of the way disc galaxies have evolved over the last 11 billion years.

  4. The Effect of Diffusion Rates in Optical Fiber Polymer Coatings on Aging Janet L. Armstrong,a M. John Matthewson, Mayra G. Juarez, Catherine Y. Chou

    E-print Network

    Matthewson, M. John

    The Effect of Diffusion Rates in Optical Fiber Polymer Coatings on Aging Janet L. Armstrong,a M, diffusion, aging knee 1. INTRODUCTION 1.1 Equilibration Before the effects of the environment of strength reduction during static fatigue and zero stress aging for long times in aggressive environments

  5. Radicular interdural lumbar disc herniation.

    PubMed

    Akhaddar, Ali; Boulahroud, Omar; Elasri, Abad; Elmostarchid, Brahim; Boucetta, Mohammed

    2010-07-01

    Intraradicular lumbar disc herniation is a rare complication of disc disease that is generally diagnosed only during surgery. The mechanism for herniated disc penetration into the intradural space is not known with certainty, but adhesion between the radicular dura and the posterior longitudinal ligament was suggested as the most important condition. The authors report the first case of an intraradicular lumbar disc herniation without subdural penetration; the disc hernia was lodged between the two radicular dura layers. The patient, a 34-year-old soldier, was admitted with a 12-month history of low back pain and episodic left sciatica. Neurologic examination showed a positive straight leg raising test on the left side without sensory, motor or sphincter disturbances. Spinal CT scan and MRI exploration revealed a left posterolateral osteophyte formation at the L5-S1 level with an irregular large disc herniation, which migrated superiorly. An intradural extension was suspected. A left L5 hemilaminectomy and S1 foraminotomy were performed. The exploration revealed a large fragment of disc material located between the inner and outer layers of the left S1 radicular dura. The mass was extirpated without cerebrospinal fluid outflow. The postoperative course was uneventful. Radicular interdural lumbar disc herniation should be suspected when a swollen, hard and immobile nerve root is present intraoperatively. PMID:19888608

  6. New ages for Middle and Later Stone Age deposits at Mumba rockshelter, Tanzania: optically stimulated luminescence dating of quartz and feldspar grains.

    PubMed

    Gliganic, Luke A; Jacobs, Zenobia; Roberts, Richard G; Domínguez-Rodrigo, Manuel; Mabulla, Audax Z P

    2012-04-01

    The archaeological deposits at Mumba rockshelter, northern Tanzania, have been excavated for more than 70 years, starting with Margit and Ludwig Köhl-Larsen in the 1930s. The assemblages of Middle Stone Age (MSA) and Later Stone Age (LSA) artefacts collected from this site constitute the type sequences for these cultural phases in East Africa. Despite its archaeological importance, however, the chronology of the site is poorly constrained, despite the application since the 1980s of several dating methods (radiocarbon, uranium-series and amino acid racemisation) to a variety of materials recovered from the deposits. Here, we review these previous chronologies for Mumba and report new ages obtained from optically stimulated luminescence (OSL) and infrared stimulated luminescence (IRSL) measurements on single grains of quartz and multi-grain aliquots of potassium (K) feldspar from the MSA and LSA deposits. Measurements of single grains of quartz allowed the rejection of unrepresentative grains and the application of appropriate statistical models to obtain the most reliable age estimates, while measurements of K-feldspars allowed the chronology to be extended to older deposits. The seven quartz ages and four K-feldspar ages provide improved temporal constraints on the archaeological sequence at Mumba. The deposits associated with the latest Kisele Industry (Bed VI-A) and the earliest Mumba Industry (Bed V) are dated to 63.4 ± 5.7 and 56.9 ± 4.8 ka (thousands of years ago), respectively, thus constraining the time of transition between these two archaeological phases to ~60 ka. An age of 49.1 ± 4.3 ka has been obtained for the latest deposits associated with the Mumba Industry, which show no evidence for post-depositional mixing and contain ostrich eggshell (OES) beads and abundant microlithics. The Nasera Industry deposits (Bed III) contain large quantities of OES beads and date to 36.8 ± 3.4 ka. We compare the luminescence ages with the previous chronologies for Mumba, and briefly discuss how the revised chronology fits in the context of existing archaeological records and palaeoclimatic reconstructions for East Africa. PMID:22425240

  7. A SCUBA-2 850-?m survey of protoplanetary discs in the ? Orionis cluster

    NASA Astrophysics Data System (ADS)

    Williams, Jonathan P.; Cieza, Lucas A.; Andrews, Sean M.; Coulson, Iain M.; Barger, Amy J.; Casey, Caitlin M.; Chen, Chian-Chou; Cowie, Lennox L.; Koss, Michael; Lee, Nicholas; Sanders, David B.

    2013-10-01

    We present the results from a large 850-?m survey of the ? Orionis cluster using the SCUBA-2 camera on the James Clerk Maxwell Telescope. The 0.5° diameter circular region we surveyed contains 297 young stellar objects with an age estimated at about 3 Myr. We detect nine of these objects, eight of which have infrared excesses from an inner disc. We also serendipitously detect three non-stellar sources at >5? that are likely background submillimetre galaxies. The nine detected stars have inferred disc masses ranging from 5 to about 17 MJup, assuming similar dust properties as Taurus discs and an interstellar medium gas-to-dust ratio of 100. There is a net positive signal towards the positions of the individually undetected infrared excess sources indicating a mean disc mass of 0.5 MJup. Stacking the emission towards those stars without infrared excesses constrains their mean disc mass to less than 0.3 MJup, or an equivalent Earth mass in dust. The submillimetre luminosity distribution is significantly different from that in the younger Taurus region, indicating disc mass evolution as star-forming regions age and the infrared excess fraction decreases. Submillimetre Array observations reveal CO emission towards four sources demonstrating that some, but probably not much, molecular gas remains in these relatively evolved discs. These observations provide new constraints on the dust and gas mass of protoplanetary discs during the giant planet building phase and provide a reference level for future studies of disc evolution.

  8. SHEDDING NEW LIGHT ON THE AGE OF THE PALOUSE LOESS, SOUTHEASTERN WASHINGTON, USING OPTICALLY STIMULATED LUMINESCENCE DATING OF QUARTZ

    NASA Astrophysics Data System (ADS)

    Roberts, H. M.; Gaylord, D.; Foit, F. F.; Sweeney, M.; Busacca, A. J.

    2009-12-01

    A single-aliquot regenerative-dose (SAR) protocol was applied to fine-silt (4-11 micron), coarse-silt (35-50 micron), and sand-sized (90-125 micron) quartz grains extracted from loess from the Palouse, southeastern Washington. Since its introduction in 2000, this optically stimulated luminescence (OSL) dating method has been applied to a wide variety of sediments, and has been shown to be robust and reliable. A clearly defined set of quality control checks has been developed to assess the suitability of samples to which this method is applied; if a sample passes these quality checks, then the ages are considered to be reliable. For the Palouse loess samples in this study, the luminescence characteristics of the various size fractions differed, and not all quartz fractions proved to be suitable for OSL dating. The coarse-grain quartz samples appear to be contaminated with feldspar, probably as inclusions within the quartz grains. OSL ages were determined using the 35-50 micron quartz fraction; the OSL signals from both this and the 4-11 micron quartz fraction passed all of the quality control checks associated with determining an accurate and precise quartz SAR OSL age. On the basis on the luminescence characteristics, therefore, the quartz OSL ages generated are believed to be robust and reliable. At some sites within the Palouse Loess region, the quartz OSL ages generated were in agreement with independent age control provided by chemical identification of tephra layers associated with known eruptions. However, at a number of sites the quartz OSL ages and the tephra evidence did not agree. The cause of this discrepancy was unknown, but given the anticipated reliability of the quartz OSL ages, attention turned to re-evaluation and re-analysis of the tephra layers which had originally been sampled and analysed more than 15 years prior to collection of the samples for quartz OSL dating. The chronology at the site was further complicated by two much earlier studies which applied IRSL and TL dating methods to polymineral fine-grains, generating ages which were acknowledged by the authors to potentially underestimate the true age of the loess units, whilst other ages appeared to agree broadly with the ages of the tephra units identified. Both the previously published luminescence ages and tephrochronologic data, and the newly generated OSL and tephra data are evaluated; the implications for stratigraphic interpretation at these and other loess sites is discussed.

  9. Carbon, nitrogen and ?-element abundances determine the formation sequence of the Galactic thick and thin discs

    NASA Astrophysics Data System (ADS)

    Masseron, T.; Gilmore, G.

    2015-10-01

    Using the DR12 public release of APOGEE data, we show that the thin and thick discs separate very well in the space defined by [?/Fe], [Fe/H] and [C/N]. Thick disc giants have both higher [C/N] and higher [?/Fe] than do thin disc stars with similar [Fe/H]. We deduce that the thick disc is composed of lower mass stars than the thin disc. Considering the fact that at a given metallicity there is a one-to-one relation between stellar mass and age, we are then able to infer the chronology of disc formation. Both the thick and the thin discs - defined by [?/Fe] - converge in their dependence on [C/N] and [C+N/Fe] at [Fe/H]?-0.7. We conclude that (1) the majority of thick disc stars formed earlier than did the thin disc stars, (2) the formation histories of the thin and thick discs diverged early on, even when the [Fe/H] abundances are similar and (3) that the star formation rate in the thin disc has been lower than in the thick disc, at all metallicities. Although these general conclusions remain robust, we also show that current stellar evolution models cannot reproduce the observed C/N ratios for thick disc stars. Unexpectedly, reduced or inhibited canonical extra mixing is very common in field stars. While subject to abundance calibration zero-point uncertainties, this implies a strong dependence of non-canonical extra mixing along the red giant branch on the initial composition of the star and in particular on the ?-elemental abundance.

  10. Protoplanetary disc evolution and dispersal

    E-print Network

    Owen, James Edward

    2011-10-11

    to the formation of the reservoir of gas and dust from which planets will form: the protoplanetary disc. Protoplanetary discs are an inevitable outcome of star formation and their existence was postulated during the 18th century within the framework of the nebular... hypothesis. 1.1 The origin of protoplanetary discs In order to initiate the star formation process, the gas from which the star is going to form must sat- isfy a basic requirement: namely that the gravitational collapse can proceed unimpeded by the thermal...

  11. Amiodarone induced optic neuropathy

    PubMed Central

    Nagra, P K; Foroozan, R; Savino, P J; Castillo, I; Sergott, R C

    2003-01-01

    Aim: To determine the clinical features of amiodarone induced optic neuropathy, which may help distinguish it from non-arteritic anterior ischaemic optic neuropathy. Methods: Retrospective observational case series of patients diagnosed with amiodarone induced optic neuropathy at the neuro-ophthalmology service from March 1998 to February 2001. Amiodarone was discontinued after discussion with the patient's cardiologist. Visual acuity, colour vision, automated perimetry, and funduscopy were performed on initial and follow up examinations. Results: Three patients with amiodarone induced optic neuropathy presented with mildly decreased vision, visual field defects, and bilateral optic disc swelling. Upon discontinuing the medication, visual function and optic disc swelling slowly improved in all three patients. Conclusion: Amiodarone induced optic neuropathy can present with visual dysfunction, and is typically a bilateral process. Upon discontinuation of amiodarone, slow resolution of optic disc swelling occurs and visual function improves in some patients. PMID:12642303

  12. Enlivening Physics, a Local Video Disc Project.

    ERIC Educational Resources Information Center

    McInerney, M.

    1989-01-01

    Describes how to make and use an inexpensive video disc of physics demonstrations. Discusses the background, production of the disc, subject of the disc including angular momentum, "monkey and the hunter" experiment, Doppler shift, pressure of a constant volume of gas thermometer, and wave effects, and using the disc in classroom. (YP)

  13. Effect of Intravitreous Anti–Vascular Endothelial Growth Factor Therapy on Choroidal Thickness in Neovascular Age-Related Macular Degeneration Using Spectral-Domain Optical Coherence Tomography

    E-print Network

    Branchini, Lauren

    A critical method of monitoring patients with neovascular age-related macular degeneration (AMD) being treated with anti–vascular endothelial growth factor (anti-VEGF) is optical coherence tomography (OCT), which uses ...

  14. Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma

    PubMed Central

    Pahlitzsch, Milena; Torun, Necip; Erb, Carl; Bruenner, Jeanette; Maier, Anna Karina B; Gonnermann, Johannes; Bertelmann, Eckart; Klamann, Matthias K J

    2015-01-01

    Purpose To assess the correlation between the disc damage likelihood scale (DDLS) objectively measured by a non-mydriatic fundus camera, Heidelberg Retina Tomograph 3, and optic coherence tomography in preperimetric glaucoma. Methods One-hundred-twenty-five patients with preperimetric primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (n=30) were included (mean age 58.9±15.9 years). All three devices graded the optic disc topography: Diagnosis 1 was defined as “outside normal limits”, while Diagnosis 2 as “borderline or outside normal limits”. Results For Diagnosis 1, a significant correlation was shown between DDLS and Moorfields regression analysis (P=0.022), and for Diagnosis 2 with glaucoma probability score analysis (P=0.024), in POAG. In pseudoexfoliation glaucoma, DDLS did not correlate significantly with Heidelberg Retina Tomograph 3 and optic coherence tomography. Regarding the area under the curve the highest predictive power was demonstrated by the objective DDLS (0.513–0.824) compared to Burk (0.239–0.343) and Mikelberg (0.093–0.270) coefficients. Conclusions The DDLS showed a significant correlation to the Moorfields regression analysis in preperimetric POAG. The objective DDLS showed the highest predictive power and thus is an additive tool in diagnosing preperimetric glaucoma. PMID:26640365

  15. Constraints on AGN accretion disc viscosity derived from continuum variability

    E-print Network

    Starling, R L C; Uttley, P; Soria, R; Starling, Rhaana L. C.; Siemiginowska, Aneta; Uttley, Phil; Soria, Roberto

    2004-01-01

    We estimate a value of the viscosity parameter in AGN accretion discs for the PG quasar sample. We assume that optical variability on time-scales of months to years is caused by local instabilities in the inner accretion disc. Comparing the observed variability time-scales to the thermal time-scales of alpha-disc models we obtain constraints on the viscosity parameter for the sample. We find that, at a given L/L_Edd, the entire sample is consistent with a single value of the viscosity parameter, alpha. We obtain constraints of 0.01 < alpha < 0.03 for 0.01 < L/L_Edd < 1.0. This narrow range suggests that these AGN are all seen in a single state, with a correspondingly narrow spread of black hole masses or accretion rates. The value of alpha we derive is consistent with predictions by current simulation s in which MHD turbulence is the primary viscosity mechanism.

  16. Correlation of Aging and Segmental Choroidal Thickness Measurement using Swept Source Optical Coherence Tomography in Healthy Eyes

    PubMed Central

    Wakatsuki, Yu; Shinojima, Ari; Kawamura, Akiyuki; Yuzawa, Mitsuko

    2015-01-01

    Purpose To assess and compare choroidal thickness changes related to aging, we determined whether changes are due to thinning of the choriocapillaris plus Sattler's (CS) layer and/or the large vessel layer in healthy eyes using swept-source optical coherence tomography (SS-OCT) at a wavelength of 1,050-nm. Methods We studied 115 normal eyes of 115 healthy volunteers, all with refractive errors of less than -6 diopters. All 115 eyes underwent analysis of choroidal thickness at the fovea, the CS layer and the large choroidal vessel layer. In 68 of the 115 eyes, choroidal thickness was determined at five sites (the fovea, and superior, inferior, nasal, and temporal sites) using SS-OCT with an Early Treatment of Diabetic Retinopathy grid scan. Results Total choroidal thicknesses at each of the five sites were related to subject age (P<0.0001). The choroid was thinnest at the nasal site, followed by the temporal, inferior, superior and finally the subfoveal site itself. The total choroidal thickness at the nasal site was significantly less than those at the other four sites (p<0.05). The CS layer showed thinning which correlated with age (P<0.0001). The thickness of the choroidal large vessel layer also decreased with age (p = 0.02). Subfoveal choroidal thickness was calculated as follows: 443.89–2.98×age (?m) (P<0.0001). Conclusion Subfoveal choroidal thickness decreases by 2.98 ?m each year. Total choroidal thickness diminishes with age. The CS and large vessel layers of the choroid at the subfovea showed significant decreases, though only the former correlated strongly with age. PMID:26632821

  17. Disc Golf, a Growing Sport

    PubMed Central

    Nelson, Joseph T.; Jones, Richard E.; Runstrom, Michael; Hardy, Jolene

    2015-01-01

    Background Disc golf is a sport played much like traditional golf, but rather than using a ball and club, players throw flying discs with various throwing motions. It has been played by an estimated 8 to 12 million people in the United States. Like all sports, injuries sustained while playing disc golf are not uncommon. Although formalized in the 1970s, it has grown at a rapid pace; however, disc golf–related injuries have yet to be described in the medical literature. Purpose To describe the most common injuries incurred by disc golf players while comparing the different types of throwing styles. Study Design Descriptive epidemiology study. Methods The data in this study were collected from 883 disc golf players who responded to an online survey collected over a 1-month period. Respondents answered 49 questions related to demographics, experience, style of play, and injury details. Using a chi-square analysis, common injuries sustained in players using backhand and forehand throwing styles were compared. Results More than 81% of respondents stated that they had sustained an injury playing disc golf, including injuries to the elbow (n = 325), shoulder (n = 305), back (n = 218), and knee (n = 199). The injuries were most commonly described as a muscle strain (n = 241), sprain (n = 162), and tendinitis (n = 145). The type of throw primarily used by players varied, with 86.2% using backhand, 12.7% using forehand, and 1.1% using an overhead throw. Players using a forehand throw were more likely to sustain an elbow injury (P = .014). Many players (n = 115) stated they had undergone surgery due to a disc golf–related injury, with the most common surgeries including meniscal, shoulder, spine, and foot/ankle surgeries. Conclusion The majority of surveyed disc golfers sustained at least 1 injury while playing disc golf, with many requiring surgery. The types of injuries sustained by players varied by the types of throw primarily used. As the sport of disc golf continues to expand, health professionals should be aware of injuries sustained, with future studies focusing on injury prevention and education strategies. PMID:26665099

  18. Histological analysis of surgical lumbar intervertebral disc tissue provides evidence for an association between disc degeneration and increased body mass index

    PubMed Central

    2011-01-01

    Background Although histopathological grading systems for disc degeneration are frequently used in research, they are not yet integrated into daily care routine pathology of surgical samples. Therefore, data on histopathological changes in surgically excised disc material and their correlation to clinical parameters such as age, gender or body mass index (BMI) is limited to date. The current study was designed to correlate major physico-clinical parameters from a population of orthopaedic spine center patients (gender, age and BMI) with a quantitative histologic degeneration score (HDS). Methods Excised lumbar disc material from 854 patients (529 men/325 women/mean age 56 (15-96) yrs.) was graded based on a previously validated histologic degeneration score (HDS) in a cohort of surgical disc samples that had been obtained for the treatment of either disc herniation or discogenic back pain. Cases with obvious inflammation, tumor formation or congenital disc pathology were excluded. The degree of histological changes was correlated with sex, age and BMI. Results The HDS (0-15 points) showed significantly higher values in the nucleus pulposus (NP) than in the annulus fibrosus (AF) (Mean: NP 11.45/AF 7.87), with a significantly higher frequency of histomorphological alterations in men in comparison to women. Furthermore, the HDS revealed a positive significant correlation between the BMI and the extent of histological changes. No statistical age relation of the degenerative lesions was seen. Conclusions This study demonstrated that histological disc alterations in surgical specimens can be graded in a reliable manner based on a quantitative histologic degeneration score (HDS). Increased BMI was identified as a positive risk factor for the development of symptomatic, clinically significant disc degeneration. PMID:22087871

  19. Clinical Impact of Sagittal Spinopelvic Parameters on Disc Degeneration in Young Adults

    PubMed Central

    Oh, Young-Min; Eun, Jong-Pil

    2015-01-01

    Abstract The sagittal balance plays an important role in the determination of shear and compressive forces applied on the anterior (vertebral bodies and intervertebral discs) and posterior (facet joints) elements of the lumbar vertebral column. Many studies have also examined the effect of structural changes in the disc on the biomechanical characteristics of the spinal segment. Nevertheless, the relationship between sagittal balance and the degree of disc degeneration has not been extensively explored. Thus, here we investigated the relationships between various sagittal spinopelvic parameters and the degree of disc degeneration in young adults. A total of 278 young adult male patients were included in this study (age range: 18–24 years old). Multiple sagittal spinopelvic parameters, including pelvic incidence (PI), sacral slope (SS), pelvic tilt (PT), lumbar lordosis (LL), sacral inclination (SI), lumbosacral angle (LSA), and sacral table angle (STA), were measured from standing lateral lumbosacral radiographs. The degree of intervertebral disc degeneration was classified using a modified Pfirrmann scale. To assess the pain intensity of each patient, the visual analogue scale (VAS) score for low back pain (LBP) was obtained from all the patients. Finally, the relationships between these spinopelvic parameters and the degree of disc degeneration in young adults were analyzed. Also, we performed multiple logistic regression study. Out of all the spinopelvic parameters measured in this study, a low STA and a low SI were the only significant risk factors that were associated with disc degeneration in young adults. It means that patients with disc degeneration tend to have more severe sacral kyphosis and vertical sacrum. We found that patients with disc degeneration showed a lower SI and lower STA compared with patients without disc degeneration in young adults. Therefore, we suggest that the patients with disc degeneration tend to have more vertical sacrum, more sacral kyphosis, and more severe LBP, and that SI and STA measurements should be carefully considered to predict or prevent further disc degeneration and LBP. PMID:26496324

  20. Clinical Impact of Sagittal Spinopelvic Parameters on Disc Degeneration in Young Adults.

    PubMed

    Oh, Young-Min; Eun, Jong-Pil

    2015-10-01

    The sagittal balance plays an important role in the determination of shear and compressive forces applied on the anterior (vertebral bodies and intervertebral discs) and posterior (facet joints) elements of the lumbar vertebral column. Many studies have also examined the effect of structural changes in the disc on the biomechanical characteristics of the spinal segment. Nevertheless, the relationship between sagittal balance and the degree of disc degeneration has not been extensively explored. Thus, here we investigated the relationships between various sagittal spinopelvic parameters and the degree of disc degeneration in young adults.A total of 278 young adult male patients were included in this study (age range: 18-24 years old). Multiple sagittal spinopelvic parameters, including pelvic incidence (PI), sacral slope (SS), pelvic tilt (PT), lumbar lordosis (LL), sacral inclination (SI), lumbosacral angle (LSA), and sacral table angle (STA), were measured from standing lateral lumbosacral radiographs. The degree of intervertebral disc degeneration was classified using a modified Pfirrmann scale. To assess the pain intensity of each patient, the visual analogue scale (VAS) score for low back pain (LBP) was obtained from all the patients. Finally, the relationships between these spinopelvic parameters and the degree of disc degeneration in young adults were analyzed. Also, we performed multiple logistic regression study.Out of all the spinopelvic parameters measured in this study, a low STA and a low SI were the only significant risk factors that were associated with disc degeneration in young adults. It means that patients with disc degeneration tend to have more severe sacral kyphosis and vertical sacrum.We found that patients with disc degeneration showed a lower SI and lower STA compared with patients without disc degeneration in young adults. Therefore, we suggest that the patients with disc degeneration tend to have more vertical sacrum, more sacral kyphosis, and more severe LBP, and that SI and STA measurements should be carefully considered to predict or prevent further disc degeneration and LBP. PMID:26496324

  1. A SCUBA-2 850-?m survey of protoplanetary discs in the IC 348 cluster

    NASA Astrophysics Data System (ADS)

    Cieza, L.; Williams, J.; Kourkchi, E.; Andrews, S.; Casassus, S.; Graves, S.; Schreiber, M. R.

    2015-12-01

    We present 850-?m observations of the 2-3 Myr cluster IC 348 in the Perseus molecular cloud using the SCUBA-2 camera on the James Clerk Maxwell Telescope. Our SCUBA-2 map has a diameter of 30 arcmin and contains ˜370 cluster members, including ˜200 objects with IR excesses. We detect a total of 13 discs. Assuming standard dust properties and a gas-to-dust-mass ratio of 100, we derive disc masses ranging from 1.5 to 16 MJUP. We also detect six Class 0/I protostars. We find that the most massive discs (MD > 3 MJUP; 850-?m flux > 10 mJy) in IC 348 tend to be transition objects according to the characteristic `dip' in their infrared spectral energy distributions (SEDs). This trend is also seen in other regions. We speculate that this could be an initial conditions effect (e.g. more massive discs tend to form giant planets that result in transition disc SEDs) and/or a disc evolution effect (the formation of one or more massive planets results in both a transition disc SED and a reduction of the accretion rate, increasing the lifetime of the outer disc). A stacking analysis of the discs that remain undetected in our SCUBA-2 observations suggests that their median 850-?m flux should be ?1 mJy, corresponding to a disc mass ?0.3 MJUP (gas plus dust) or ?1 M? of dust. While the available data are not deep enough to allow a meaningful comparison of the disc luminosity functions between IC 348 and other young stellar clusters, our results imply that disc masses exceeding the minimum-mass solar nebula are very rare (?1per cent) at the age of IC 348, especially around very low-mass stars.

  2. Preclinical and clinical experience with a viscoelastic total disc replacement

    PubMed Central

    Rischke, Burkhard; Ross, Raymond S.; Jollenbeck, Boris A.; Zimmers, Kari B.; Defibaugh, Neal D.

    2011-01-01

    Background The purpose of this study is to describe the mechanical durability and the clinical and radiographic outcomes of a viscoelastic total disc replacement (VTDR). The human intervertebral disc is a complex, viscoelastic structure, permitting and constraining motion in 3 axes, thus providing stability. The ideal disc replacement should be viscoelastic and deformable in all directions, and it should restore disc height and angle. Methods Mechanical testing was conducted to validate the durability of the VTDR, and a clinical study was conducted to evaluate safety and performance. Fifty patients with single-level, symptomatic lumbar degenerative disc disease at L4-5 or L5-S1 were enrolled in a clinical trial at 3 European sites. Patients were assessed clinically and radiographically for 2 years by the Oswestry Disability Index (ODI), a visual analog scale (VAS), and independent radiographic analyses. Results The VTDR showed a fatigue life in excess of 50 million cycles (50-year equivalent) and a physiologically appropriate level of stiffness, motion, geometry, and viscoelasticity. We enrolled 28 men and 22 women in the clinical study, with a mean age of 40 years. Independent quantitative radiographic assessment indicated that the VTDR restored and maintained disc height and lordosis while providing physiologic motion. Mean ODI scores decreased from 48% preoperatively to 23% at 2 years’ follow-up. Mean VAS low-back pain scores decreased from 7.1 cm to 2.9 cm. Median scores indicated that half of the patient population had ODI scores below 10% and VAS low-back pain scores below 0.95 cm at 2 years. Conclusions The VTDR has excellent durability and performs clinically and radiographically as intended for the treatment of symptomatic lumbar degenerative disc disease. Clinical Relevance The VTDR is intended to restore healthy anatomic properties and stability characteristics to the spinal segment. This study is the first to evaluate a VTDR in a 50-patient, multicenter European study. PMID:25802675

  3. Optically stimulated luminescence age controls on late Pleistocene and Holocene coastal lithosomes, North Carolina, USA

    USGS Publications Warehouse

    Mallinson, D.; Burdette, K.; Mahan, S.; Brook, G.

    2008-01-01

    Luminescence ages from a variety of coastal features on the North Carolina Coastal Plain provide age control for shoreline formation and relative sea-level position during the late Pleistocene. A series of paleoshoreline ridges, dating to Marine Isotope Stage (MIS) 5a and MIS 3 have been defined. The Kitty Hawk beach ridges, on the modern Outer Banks, yield ages of 3 to 2??ka. Oxygen-isotope data are used to place these deposits in the context of global climate and sea-level change. The occurrence of MIS 5a and MIS 3 shorelines suggests that glacio-isostatic adjustment (GIA) of the study area is large (ca. 22 to 26??m), as suggested and modeled by other workers, and/or MIS 3 sea level was briefly higher than suggested by some coral reef studies. Correcting the shoreline elevations for GIA brings their elevation in line with other sea-level indicators. The age of the Kitty Hawk beach ridges places the Holocene shoreline well west of its present location at ca. 3 to 2??ka. The age of shoreline progradation is consistent with the ages of other beach ridge complexes in the southeast USA, suggesting some regionally contemporaneous forcing mechanism. ?? 2007 University of Washington.

  4. Study of the stellar population properties in the discs of ten spiral galaxies

    NASA Astrophysics Data System (ADS)

    Morelli, L.; Corsini, E. M.; Pizzella, A.; Dalla Bontà, E.; Coccato, L.; Méndez-Abreu, J.

    2015-09-01

    We investigated the properties of the stellar populations in the discs of a sample of 10 spiral galaxies. Our analysis focused on the galaxy region where the disc contributes more than 95 per cent of total surface brightness in order to minimize the contamination of the bulge and bar. The luminosity-weighted age and metallicity were obtained by fitting the galaxy spectra with a linear combination of stellar population synthesis models, while the total overabundance of ?-elements over iron was derived by measuring the line-strength indices. Most of the sample discs display a bimodal age distribution and they are characterized by a total [?/Fe] enhancement ranging from solar and supersolar. We interpreted the age bimodality as due to the simultaneous presence of both a young (Age ? 4 Gyr) and an old (Age > 4 Gyr) stellar population. The old stellar component usually dominates the disc surface brightness and its light contribution is almost constant within the observed radial range. For this reason, no age gradient is observed in half of the sample galaxies. The old component is slightly more metal poor than the young one. The metallicity gradient is negative and slightly positive in the old and young components, respectively. These results are in agreement with an inside-out scenario of disc formation and suggest a reduced impact of the radial migration on the stellar populations of the disc. The young component could be the result of a second burst of star formation in gas captured from the environment.

  5. Reoperations Following Cervical Disc Replacement

    PubMed Central

    Skovrlj, Branko; Lee, Dong-Ho; Caridi, John Michael

    2015-01-01

    Cervical disc replacement (CDR) has emerged as an alternative surgical option to cervical arthrodesis. With increasing numbers of patients and longer follow-ups, complications related to the device and/or aging spine are growing, leaving us with a new challenge in the management and surgical revision of CDR. The purpose of this study is to review the current literature regarding reoperations following CDR and to discuss about the approaches and solutions for the current and future potential complications associated with CDR. The published rates of reoperation (mean, 1.0%; range, 0%-3.1%), revision (mean, 0.2%; range, 0%-0.5%), and removal (mean, 1.2%; range, 0%-1.9%) following CDR are low and comparable to the published rates of reoperation (mean, 1.7%; range; 0%-3.4%), revision (mean, 1.5%; range, 0%-4.7%), and removal (mean, 2.0%; range, 0%-3.4%) following cervical arthrodesis. The surgical interventions following CDR range from the repositioning to explantation followed by fusion or the reimplantation to posterior foraminotomy or fusion. Strict patient selection, careful preoperative radiographic review and surgical planning, as well as surgical technique may reduce adverse events and the need for future intervention. Minimal literature and no guidelines exist for the approaches and techniques in revision and for the removal of implants following CDR. Adherence to strict indications and precise surgical technique may reduce the number of reoperations, revisions, and removals following CDR. Long-term follow-up studies are needed, assessing the implant survivorship and its effect on the revision and removal rates. PMID:26097667

  6. On the Absolute Age of the Metal-rich Globular M71 (NGC 6838). I. Optical Photometry

    NASA Astrophysics Data System (ADS)

    Di Cecco, A.; Bono, G.; Prada Moroni, P. G.; Tognelli, E.; Allard, F.; Stetson, P. B.; Buonanno, R.; Ferraro, I.; Iannicola, G.; Monelli, M.; Nonino, M.; Pulone, L.

    2015-08-01

    We investigated the absolute age of the Galactic globular cluster M71 (NGC 6838) using optical ground-based images (u\\prime ,g\\prime ,r\\prime ,i\\prime ,z\\prime ) collected with the MegaCam camera at the Canada–France–Hawaii Telescope (CFHT). We performed a robust selection of field and cluster stars by applying a new method based on the 3D (r\\prime ,u\\prime -g\\prime ,g\\prime -r\\prime ) color–color–magnitude diagram. A comparison between the color–magnitude diagram (CMD) of the candidate cluster stars and a new set of isochrones at the locus of the main sequence turn-off (MSTO) suggests an absolute age of 12 ± 2 Gyr. The absolute age was also estimated using the difference in magnitude between the MSTO and the so-called main sequence knee, a well-defined bending occurring in the lower main sequence. This feature was originally detected in the near-infrared bands and explained as a consequence of an opacity mechanism (collisionally induced absorption of molecular hydrogen) in the atmosphere of cool low-mass stars. The same feature was also detected in the r?, u\\prime -g\\prime , and in the r\\prime ,g\\prime -r\\prime CMD, thus supporting previous theoretical predictions by Borysow et al. The key advantage in using the {{{? }}}{TO}{Knee} as an age diagnostic is that it is independent of uncertainties affecting the distance, the reddening, and the photometric zero point. We found an absolute age of 12 ± 1 Gyr that agrees, within the errors, with similar age estimates, but the uncertainty is on average a factor of two smaller. We also found that the {{{? }}}{TO}{Knee} is more sensitive to the metallicity than the MSTO, but the dependence vanishes when using the difference in color between the MSK and the MSTO.

  7. The effect of aging on smoke optical properties and scavenging characteristics

    SciTech Connect

    Penner, J.E.

    1986-11-01

    Aging of smoke in dense smoke plumes is known to alter its size distribution and scavenging characteristics. In this paper, I review data pertaining to these processes and compare them to model simulations of the coagulation of smoke. Model simulations of the degree of smoke coagulation in the first few days after a nuclear war are summarized. The predicted size of smoke particles after several days of coagulation is found to be larger than that of any data pertaining to the absorption properties of smoke. Thus, it is suggested that more relevant data on the absorption properties of smoke is needed. I also review aging experiments pertaining to the number of cloud condensation nuclei in a smoke sample. I show that the fraction of smoke particles which act as CCN after aging depends on the number of particles initially present in the aging chamber. Smoke from an acetylene flame can quickly coagulate to sizes wherein nearly all of the particles act as CCN. On the other hand, only 10% of the smoke particles from an outdoor fire of gasoline and diesel fuel became CCN after 30 hours of aging. The development of CCN concentrations in this experiment may have been quenched by low initial concentrations in the aging chamber. Both experiments are consistent with particles as small as 0.08 micron in radius (and perhaps even smaller) acting as CCN. Model simulations of the coagulation of smoke particles above a large, intense fire show that coagulation would allow approximately 50% of the particles to become larger than 0.08 micron before the plume reaches cloud base. Furthermore, aging over several days time would transform nearly all the particles into the scavengable size range.

  8. The far-infrared behaviour of Herbig Ae/Be discs: Herschel PACS photometry

    E-print Network

    Pascual, N; Meeus, G; Marshall, J P; Mendigutía, I; Sandell, G

    2015-01-01

    Herbig Ae/Be objects are pre-main sequence stars surrounded by gas- and dust-rich circumstellar discs. These objects are in the throes of star and planet formation, and their characterisation informs us of the processes and outcomes of planet formation processes around intermediate mass stars. Here we analyse the spectral energy distributions of disc host stars observed by the Herschel Open Time Key Programme `Gas in Protoplanetary Systems'. We present Herschel/PACS far-infrared imaging observations of 22 Herbig Ae/Bes and 5 debris discs, combined with ancillary photometry spanning ultraviolet to sub-millimetre wavelengths. From these measurements we determine the diagnostics of disc evolution, along with the total excess, in three regimes spanning near-, mid-, and far-infrared wavelengths. Using appropriate statistical tests, these diagnostics are examined for correlations. We find that the far-infrared flux, where the disc becomes optically thin, is correlated with the millimetre flux, which provides a meas...

  9. Dynamical and chemical evolution of the thin disc

    E-print Network

    Just, Andreas

    2015-01-01

    Our detailed analytic local disc model (JJ-model) quantifies the interrelation between kinematic properties (e.g. velocity dispersions and asymmetric drift), spatial parameters (scale-lengths and vertical density profiles), and properties of stellar sub-populations (age and abundance distributions). Any consistent radial extension of the disc evolution model should predict specific features in the different distribution functions and in their correlations. Large spectroscopic surveys (SEGUE, RAVE, APOGEE, Gaia-ESO) allow significant constraints on the long-term evolution of the thin disc. We discuss the qualitative difference of correlations (like the alpha-enhancement as function of metallicity) and distribution functions (e.g. in [Mg/H] or [Fe/H]) for the construction of a disc model. In the framework of the JJ-model we build a local chemical enrichment model and show that significant vertical gradients for main sequence and red clump stars are expected in the thin disc. A Jeans analysis of the asymmetric d...

  10. Quantitative analysis of three-dimensional fibrillar collagen microstructure within the normal, aged and glaucomatous human optic nerve head

    PubMed Central

    Jones, H. J.; Girard, M. J.; White, N.; Fautsch, M. P.; Morgan, J. E.; Ethier, C. R.; Albon, J.

    2015-01-01

    The aim of this study was to quantify connective tissue fibre orientation and alignment in young, old and glaucomatous human optic nerve heads (ONH) to understand ONH microstructure and predisposition to glaucomatous optic neuropathy. Transverse (seven healthy, three glaucomatous) and longitudinal (14 healthy) human ONH cryosections were imaged by both second harmonic generation microscopy and small angle light scattering (SALS) in order to quantify preferred fibre orientation (PFO) and degree of fibre alignment (DOFA). DOFA was highest within the peripapillary sclera (ppsclera), with relatively low values in the lamina cribrosa (LC). Elderly ppsclera DOFA was higher than that in young ppsclera (p < 0.00007), and generally higher than in glaucoma ppsclera. In all LCs, a majority of fibres had preferential orientation horizontally across the nasal–temporal axis. In all glaucomatous LCs, PFO was significantly different from controls in a minimum of seven out of 12 LC regions (p < 0.05). Additionally, higher fibre alignment was observed in the glaucomatous inferior–temporal LC (p < 0.017). The differences between young and elderly ONH fibre alignment within regions suggest that age-related microstructural changes occur within the structure. The additional differences in fibre alignment observed within the glaucomatous LC may reflect an inherent susceptibility to glaucomatous optic neuropathy, or may be a consequence of ONH remodelling and/or collapse. PMID:25808336

  11. Morphological analysis of age-related iridocorneal angle changes in normal and glaucomatous cases using anterior segment optical coherence tomography

    PubMed Central

    Maruyama, Yuko; Mori, Kazuhiko; Ikeda, Yoko; Ueno, Morio; Kinoshita, Shigeru

    2014-01-01

    Purpose To analyze age-related morphological changes of the iridocorneal angle in normal subjects and glaucomatous cases, using anterior segment optical coherence tomography (AS-OCT). Methods This study involved 58 eyes of 58 open-angle glaucoma cases and 72 eyes of 72 age-matched normal-open-angle control subjects. Iridocorneal angle structures in nasal and temporal regions and anterior chamber depth (ACD) were measured using AS-OCT. Axial length and refractive error were measured by use of an ocular biometer and auto refractor keratometer. Angle opening distance (AOD), angle recess area (ARA), and trabecular-iris space area (TISA), measured at 500 ?m (TISA500) and 750 ?m (TISA750) distant from the scleral spur, were calculated, in the nasal and temporal regions. A new index, the peripheral angle frame index (PAFI), which represents the peripheral angle structure, was proposed, and was defined as (TISA750-TISA500)/TISA500. Results Refractive power in the glaucoma cases was less than in control cases (P<0.0001). Axial length (P<0.0001) and ACD (P=0.0004) were longer and deeper, respectively, in the glaucoma cases, compared with the control cases. In both control and glaucoma groups, ACD, AOD, ARA, and TISA decreased linearly in an age-dependent manner, while PAFI stayed at relatively constant values throughout the age distribution. AOD in the glaucoma group was longer than in the control group, in both the temporal and nasal regions; ARA and TISA were larger in the glaucoma than in the control group. However, no significant differences in nasal or temporal PAFI were found between the glaucoma and control groups. Conclusion The findings of this study show that AS-OCT is useful for the quantitative evaluation of age-related changes in peripheral angle structure in glaucoma and control cases. PMID:24379654

  12. A focussing disc DIRC for PANDA

    NASA Astrophysics Data System (ADS)

    Cowie, E. N.; Britting, A.; Clarkson, A.; Dodokhof, V. KH.; Düren, M.; Dutta, D.; Eyrich, W.; Föhl, K.; Glazer, D. I.; Hayrapetyan, A.; Hoek, M.; Hohler, R.; Kaiser, R.; Keri, T.; Koch, P.; Kröck, B.; Lehmann, A.; Lehmann, D.; Lumsden, S.; Marton, J.; Merle, O.; Montgomery, R.; Peters, K.; Reinicke, S.; Rosner, G.; Roy, B.; Schepers, G.; Schmitt, L.; Schwarz, C.; Schwiening, J.; Seitz, B.; Sfienti, C.; Suzuki, K.; Uhlig, F.; Vodopianov, A. S.; Watts, D. P.; Yu, W.

    2011-05-01

    The PANDA experiment at the FAIR upgrade to GSI, Darmstadt, aims to study modern hadronic physics with unprecedented precision. Excellent particle identification of both charged and neutral particles is necessary to achieve the physics aims of PANDA. Two DIRC detectors are foreseen for charged particle identification, one in a barrel configuration for the central region, and the second in a disc configuration for the forward endcap. The design of the forward disc DIRC centres around the novel application of passive chromatic dispersion correction elements, allied with focussing optics, to achieve excellent resolution of Chernekov angle. A system of comprehensive prototype development will show the feasibility of the system. Key to the success of the prototype is fully understanding the production, transport and detection of the Cherenkov photons within the detector. Photon yield and its dependence on the polar angle of the detector have been measured. Observed photon yield is also the basis for subsequent studies into the benefit of chromatic dispersion correction elements, focussing and overall detector performance.

  13. Phase object imaging inside the airy disc

    NASA Astrophysics Data System (ADS)

    Tychinsky, Vladimir P.

    1991-03-01

    The possibility of phase objects superresoluton imaging is theoretically justifieth The measurements with CPM " AIRYSCAN" showed the reality of O structures observations when the Airy disc di ameter i s 0 86 j. . m SUMMARY It has been known that the amount of information contained in the image of any object is mostly determined by the number of points measured i ndependentl y or by spati al resol uti on of the system. From the classic theory of the optical systems it follows that for noncoherent sources the -spatial resolution is limited by the aperture dd 6LX/N. A. ( Rayleigh criterion where X is wave length NA numerical aperture. ) The use of this criterion is equivalent tO the statement that any object inside the Airy disc of radius d that is the difraction image of a point is practical ly unresolved. However at the coherent illumination the intensity distribution in the image plane depends also upon the phase iq (r) of the wave scattered by the object and this is the basis of the Zernike method of phasecontrast microscopy differential interference contrast (DIC) and computer phase microscopy ( CPM ). In theoretical foundation of these methods there was no doubt in the correctness of Rayleigh criterion since the phase information is derived out of intensity distribution and as we know there were no experiments that disproved this

  14. Chondrule transport in protoplanetary discs

    NASA Astrophysics Data System (ADS)

    Goldberg, Aaron Z.; Owen, James E.; Jacquet, Emmanuel

    2015-10-01

    Chondrule formation remains one of the most elusive early Solar system events. Here, we take the novel approach of employing numerical simulations to investigate chondrule origin beyond purely cosmochemical methods. We model the transport of generically produced chondrules and dust in a 1D viscous protoplanetary disc model in order to constrain the chondrule formation events. For a single formation event we are able to match analytical predictions of the memory they retain of each other (complementarity), finding that a large mass accretion rate (?10-7 M? yr-1) allows for delays on the order of the disc's viscous time-scale between chondrule formation and chondrite accretion. Further, we find older discs to be severely diminished of chondrules, with accretion rates ?10-9 M? yr-1 for nominal parameters. We then characterize the distribution of chondrule origins in both space and time, as functions of disc parameters and chondrule formation rates, in runs with continuous chondrule formation and both static and evolving discs. Our data suggest that these can account for the observed diversity between distinct chondrite classes, if some diversity in accretion time is allowed for.

  15. Laser microbeams for DNA damage induction, optical tweezers for the search on blood pressure relaxing drugs: contributions to ageing research

    NASA Astrophysics Data System (ADS)

    Grigaravicius, P.; Monajembashi, S.; Hoffmann, M.; Altenberg, B.; Greulich, K. O.

    2009-08-01

    One essential cause of human ageing is the accumulation of DNA damages during lifetime. Experimental studies require quantitative induction of damages and techniques to visualize the subsequent DNA repair. A new technique, the "immuno fluorescent comet assay", is used to directly visualize DNA damages in the microscope. Using DNA repair proteins fluorescently labeled with green fluorescent protein, it could be shown that the repair of the most dangerous DNA double strand breaks starts with the inaccurate "non homologous end joining" pathway and only after 1 - 1 ½ minutes may switch to the more accurate "homologous recombination repair". One might suggest investigating whether centenarians use "homologous recombination repair" differently from those ageing at earlier years and speculate whether it is possible, for example by nutrition, to shift DNA repair to a better use of the error free pathway and thus promote healthy ageing. As a complementary technique optical tweezers, and particularly its variant "erythrocyte mediated force application", is used to simulate the effects of blood pressure on HUVEC cells representing the inner lining of human blood vessels. Stimulating one cell induces in the whole neighbourhood waves of calcium and nitric oxide, known to relax blood vessels. NIFEDIPINE and AMLODIPINE, both used as drugs in the therapy of high blood pressure, primarily a disease of the elderly, prolong the availability of nitric oxide. This partially explains their mode of action. In contrast, VERAPAMILE, also a blood pressure reducing drug, does not show this effect, indicating that obviously an alternative mechanism must be responsible for vessel relaxation.

  16. The absolute age of the globular cluster M15 using near-infrared adaptive optics images from PISCES/LBT

    E-print Network

    Monelli, M; Bono, G; Ferraro, I; Iannicola, G; Fiorentino, G; Arcidiacono, C; Massari, D; Boutsia, K; Briguglio, R; Busoni, L; Carini, R; Close, L; Cresci, G; Esposito, S; Fini, L; Fumana, M; Guerra, J C; Hill, J; Kulesa, C; Mannucci, F; McCarthy, D; Pinna, E; Puglisi, A; Quiros-Pacheco, F; Ragazzoni, R; Riccardi, A; Skemer, A; Xompero, M

    2015-01-01

    We present deep near-infrared (NIR) J, Ks photometry of the old, metal-poor Galactic globular cluster M\\,15 obtained with images collected with the LUCI1 and PISCES cameras available at the Large Binocular Telescope (LBT). We show how the use of First Light Adaptive Optics system coupled with the (FLAO) PISCES camera allows us to improve the limiting magnitude by ~2 mag in Ks. By analyzing archival HST data, we demonstrate that the quality of the LBT/PISCES color magnitude diagram is fully comparable with analogous space-based data. The smaller field of view is balanced by the shorter exposure time required to reach a similar photometric limit. We investigated the absolute age of M\\,15 by means of two methods: i) by determining the age from the position of the main sequence turn-off; and ii) by the magnitude difference between the MSTO and the well-defined knee detected along the faint portion of the MS. We derive consistent values of the absolute age of M15, that is 12.9+-2.6 Gyr and 13.3+-1.1 Gyr, respectiv...

  17. Debris disc formation induced by planetary growth

    NASA Astrophysics Data System (ADS)

    Kobayashi, H.; Löhne, T.

    2014-08-01

    Several hundred stars older than 10 million years have been observed to have infrared excesses. These observations are explained by dust grains formed by the collisional fragmentation of hidden planetesimals. Such dusty planetesimal discs are known as debris discs. In a dynamically cold planetesimal disc, collisional coagulation of planetesimals produces planetary embryos which then stir the surrounding leftover planetesimals. Thus, the collisional fragmentation of planetesimals that results from planet formation forms a debris disc. We aim to determine the properties of the underlying planetesimals in debris discs by numerically modelling the coagulation and fragmentation of planetesimal populations. The brightness and temporal evolution of debris discs depend on the radial distribution of planetesimal discs, the location of their inner and outer edges, their total mass, and the size of planetesimals in the disc. We find that a radially narrow planetesimal disc is most likely to result in a debris disc that can explain the trend of observed infrared excesses of debris discsvvv around G-type stars, for which planet formation occurs only before 100 million years. Early debris disc formation is induced by planet formation, while the later evolution is explained by the collisional decay of leftover planetesimals around planets that have already formed. Planetesimal discs with underlying planetesimals of radii ˜100 km at ?30 au most readily explain the Spitzer Space Telescope 24 and 70 ?m fluxes from debris discs around G-type stars.

  18. A case of subretinal tubercular abscess presenting as disc edema.

    PubMed

    Shetty, Sachin Bermu; Bawtag, Mohammad Abdullah; Biswas, Jyotirmay

    2015-02-01

    We report a case of ocular tuberculosis (TB) which initially presented with disc edema and was mistaken for optic neuritis. With no definite pathology being identified, the patient was treated on the lines of optic neuritis with intravenous (IV) steroid with beneficial effect. Ocular TB was suspected when he presented later with a subretinal abscess. Based on positive Mantoux, QuantiFERON TB gold results and radiographic findings, a diagnosis of subretinal abscess of presumed tubercular etiology was made. The patient was successfully treated with anti-tubercular therapy. To the best of our knowledge, this is the first case report of ocular TB presenting as disc edema followed by subretinal abscess. PMID:25827550

  19. Occupational risk factors for symptomatic lumbar disc herniation; a case-control study

    PubMed Central

    Seidler, A; Bolm-Audorff, U; Siol, T; Henkel, N; Fuchs, C; Schug, H; Leheta, F; Marquardt, G; Schmitt, E; Ulrich, P; Beck, W; Missalla, A; Elsner, G

    2003-01-01

    Background: Previous studies mostly did not separate between symptomatic disc herniation combined with osteochondrosis/spondylosis of the lumbar spine and symptomatic disc herniation in radiographically normal intervertebral spaces. This may at least in part explain the differences in the observed risk patterns. Aims: To investigate the possible aetiological relevance of physical and psychosocial workload to lumbar disc herniation with and without concomitant osteochondrosis/spondylosis. Methods: A total of 267 cases with acute lumbar disc herniation (in two practices and four clinics) and 197 control subjects were studied. Data were gathered in a structured personal interview and analysed using logistic regression to control for age, region, nationality, and diseases affecting the lumbar spine. Cases without knowledge about osteochondrosis/spondylosis (n=42) were excluded from analysis. Risk factors were examined separately for those cases with (n=131) and without (n=94) radiographically diagnosed concomitant osteochondrosis or spondylosis. Results: There was a statistically significant positive association between extreme forward bending and lumbar disc herniation with, as well as without concomitant osteochondrosis/spondylosis. There was a statistically significant relation between cumulative exposure to weight lifting or carrying and lumbar disc herniation with, but not without, concomitant osteochondrosis/spondylosis. Cases with disc herniation reported time pressure at work as well as psychic strain through contact with clients more frequently than control subjects. Conclusions: Further larger studies are needed to verify the concept of distinct aetiologies of lumbar disc herniation in relatively younger persons with otherwise normal discs and of disc herniation in relatively older persons with structurally damaged discs. PMID:14573712

  20. 46 CFR 64.61 - Rupture disc.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...SECURITY (CONTINUED) MARINE ENGINEERING MARINE PORTABLE TANKS AND CARGO HANDLING SYSTEMS Pressure Relief Devices and Vacuum Relief Devices for MPTs § 64.61 Rupture disc. If a rupture disc is the only pressure relief device on the tank,...

  1. 46 CFR 64.61 - Rupture disc.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...SECURITY (CONTINUED) MARINE ENGINEERING MARINE PORTABLE TANKS AND CARGO HANDLING SYSTEMS Pressure Relief Devices and Vacuum Relief Devices for MPTs § 64.61 Rupture disc. If a rupture disc is the only pressure relief device on the tank,...

  2. 46 CFR 64.61 - Rupture disc.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...SECURITY (CONTINUED) MARINE ENGINEERING MARINE PORTABLE TANKS AND CARGO HANDLING SYSTEMS Pressure Relief Devices and Vacuum Relief Devices for MPTs § 64.61 Rupture disc. If a rupture disc is the only pressure relief device on the tank,...

  3. 46 CFR 64.61 - Rupture disc.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...SECURITY (CONTINUED) MARINE ENGINEERING MARINE PORTABLE TANKS AND CARGO HANDLING SYSTEMS Pressure Relief Devices and Vacuum Relief Devices for MPTs § 64.61 Rupture disc. If a rupture disc is the only pressure relief device on the tank,...

  4. 46 CFR 64.61 - Rupture disc.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...SECURITY (CONTINUED) MARINE ENGINEERING MARINE PORTABLE TANKS AND CARGO HANDLING SYSTEMS Pressure Relief Devices and Vacuum Relief Devices for MPTs § 64.61 Rupture disc. If a rupture disc is the only pressure relief device on the tank,...

  5. Physics and chemistry of gas in discs 

    E-print Network

    Tilling, Ian

    2013-11-28

    Protoplanetary discs set the initial conditions for planet formation. By combining observations with detailed modelling, it is possible to constrain the physics and chemistry in such discs. I have used the detailed ...

  6. DISC-UK DataShare 

    E-print Network

    Rice, Robin

    DISC-UK DataShare (http://www.disc-uk.org/datashare.html) is a JISC-funded collaborative project led by EDINA and Edinburgh University Data Library, with the Universities of Oxford and Southampton as partners, and the ...

  7. Association of Abdominal Obesity with Lumbar Disc Degeneration – A Magnetic Resonance Imaging Study

    PubMed Central

    Takatalo, Jani; Karppinen, Jaro; Taimela, Simo; Niinimäki, Jaakko; Laitinen, Jaana; Sequeiros, Roberto Blanco; Samartzis, Dino; Korpelainen, Raija; Näyhä, Simo; Remes, Jouko; Tervonen, Osmo

    2013-01-01

    Purpose To evaluate whether midsagittal (abdominal) obesity in magnetic resonance imaging (MRI), waist circumference (WC) and body fat percentage are associated with lumbar disc degeneration in early adulthood. Methods We obtained the lumbar MRI (1.5-T scanner) of 325 females and 233 males at a mean age of 21 years. Lumbar disc degeneration was evaluated using Pfirrmann classification. We analysed the associations of MRI measures of obesity (abdominal diameter (AD), sagittal diameter (SAD), ventral subcutaneous thickness (VST), and dorsal subcutaneous thickness (DST)), WC and body fat percentage with disc degeneration sum scores using ordinal logistic regression. Results A total of 155 (48%) females and 147 (63%) males had disc degeneration. AD and SAD were associated with a disc degeneration sum score of ?3 compared to disc degeneration sum score of 0–2 (OR 1.67; 95% confidence interval (CI) 1.20–2.33 and OR 1.40; 95% CI 1.12–1.75, respectively) among males, but we found no association among females. WC was also associated with disc degeneration among males (OR 1.03 per one cm; 95% CI 1.00–1.05), but not among females. Conclusion Measures of abdominal obesity in MRI and waist circumference were associated with disc degeneration among 21-year-old males. PMID:23418543

  8. Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs

    E-print Network

    Wang, Kuan Hong

    Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs 1, 2005; Revised December 30, 2005; Accepted February 8, 2006 DISC1 has been identified-terminus-truncated DISC1 disrupts intracellular transport, neural architecture and migration, perhaps because it fails

  9. [Analysis of LCD aging with polarized optical texture and transmission spectrum].

    PubMed

    Huang, Chong; Zhou, Xue-Ping; Liu, Ji; Ouyang, Yan-Dong

    2006-08-01

    Light radiation experiment was done to a group of liquid crystal display devices, and the influence of light radiation on the display quality of liquid crystal display devices was studied. The changes in their polarized textures after light radiation were observed with a polarized optical microscope. Parallel stripe texture and black holes, which lost extinction function, appeared in liquid crystal texture. With the increase of light radiation time, more and more black holes result, and the area of black holes gets bigger and bigger. The authors tested the transmission spectrum with computer-controlled ultraviolet/visible light spectrometer, finding that the transmission rate declines with the increase of light radiation time. The results show that the appearance of stripe texture and black holes resulted from the changes in liquid crystal molecular structure after ultraviolet radiation, and the occurrence of black holes, which lost extinction function, is the main reason for the continuous decline of transmission rate. PMID:17058936

  10. Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography

    NASA Astrophysics Data System (ADS)

    Baumann, Bernhard; Götzinger, Erich; Pircher, Michael; Sattmann, Harald; Schütze, Christopher; Schlanitz, Ferdinand; Ahlers, Christian; Schmidt-Erfurth, Ursula; Hitzenberger, Christoph K.

    2010-11-01

    We present polarization-sensitive optical coherence tomography (PS-OCT) for quantitative assessment of retinal pathologies in age-related macular degeneration (AMD). On the basis of the polarization scrambling characteristics of the retinal pigment epithelium, novel segmentation algorithms were developed that allow one to segment pathologic features such as drusen and atrophic zones in dry AMD as well as to determine their dimensions. Results from measurements in the eyes of AMD patients prove the ability of PS-OCT for quantitative imaging based on the retinal features polarizing properties. Repeatability measurements were performed in retinas diagnosed with drusen and geographic atrophy in order to evaluate the performance of the described methods. PS-OCT appears as a promising imaging modality for three-dimensional retinal imaging and ranging with additional contrast based on the structures' tissue-inherent polarization properties.

  11. Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography

    PubMed Central

    Baumann, Bernhard; Götzinger, Erich; Pircher, Michael; Sattmann, Harald; Schütze, Christopher; Schlanitz, Ferdinand; Ahlers, Christian; Schmidt-Erfurth, Ursula; Hitzenberger, Christoph K.

    2011-01-01

    We present polarization-sensitive optical coherence tomography (PS-OCT) for quantitative assessment of retinal pathologies in age-related macular degeneration (AMD). On the basis of the polarization scrambling characteristics of the retinal pigment epithelium, novel segmentation algorithms were developed that allow one to segment pathologic features such as drusen and atrophic zones in dry AMD as well as to determine their dimensions. Results from measurements in the eyes of AMD patients prove the ability of PS-OCT for quantitative imaging based on the retinal features polarizing properties. Repeatability measurements were performed in retinas diagnosed with drusen and geographic atrophy in order to evaluate the performance of the described methods. PS-OCT appears as a promising imaging modality for three-dimensional retinal imaging and ranging with additional contrast based on the structures’ tissue-inherent polarization properties. PMID:21198152

  12. Galactic archaeology of a thick disc: Excavating ESO 533-4 with VIMOS

    NASA Astrophysics Data System (ADS)

    Comerón, S.; Salo, H.; Janz, J.; Laurikainen, E.; Yoachim, P.

    2015-12-01

    The disc of galaxies is made of the superposition of a thin and a thick disc. Star formation is hosted in the thin discs and contributes to their growth. Thick discs are formed of old stars. The formation mechanisms of thick discs are under discussion. Thick discs might have formed either at high redshift on a short timescale or might have been built slowly over a Hubble-Lemaître time. They may have an internal or an external origin. Here we adopt a galactic archaeology approach to study the thick disc of ESO 533-4, i.e. we study the kinematics and the stellar populations of this galaxy in detail. ESO 533-4 is a Southern, nearby, and almost bulgeless galaxy. We present the first ever Integral Field Unit spectroscopy of an edge-on galaxy with enough depth and quality to study the thick disc. We exposed ESO 533-4 with the blue grism of the VIMOS instrument of the VLT for 6.5 h. The field of view covered an axial extent from ~ 0.1 r25 to ~ 0.7 r25, where r25 is the 25 mag arcsec-2 isophotal radius. This corresponds to the range from ~1 kpc to ~7 kpc. We used pPXF and the MILES library to obtain velocity and stellar population maps. We compared our kinematic data with simple GADGET-2 models. The apparent rotational lag of the thick disc of ESO 533-4 is compatible with that expected from the combinations of two effects: differential asymmetric drift and the projection effects arising from studying a disc a few degrees (2-3°) away from edge-on. Thus, ESO 533-4 contains little or no counter-rotating material. This is compatible with three formation scenarios: the secular dynamical heating of an initially thin disc, the formation of the thick disc at high redshift in an early turbulent disc phase, and the creation of a thick disc in a major merger event. If this last mechanism occurred in all galaxies, it would cause retrograde thick discs in half of them. These retrograde discs have not been observed in the five massive disc galaxies (circular velocity vc ? 120 km s-1) for which the kinematics of the thick disc is known. The stellar populations map indicates that the populations of the thin and the thick discs of ESO 533-4 are possibly separated in the Age-log (Z/Z?) plane. This would imply that thin and thick discs are formed of two distinct stellar populations. The stellar population results are not fully conclusive because of the high dust extinction in ESO 533-4 and because recovering stellar populations is a difficult inverse problem. Having said that, the stellar population results do not favour a secular evolution origin for the thick disc. Hence, we suggest that the thick disc of ESO 533-4 formed in a relatively short event. Based on observations made at the European Southern Observatory using the Very Large Telescope under programme 091.B-0228(A).

  13. Calcification in the ovine intervertebral disc: a model of hydroxyapatite deposition disease

    PubMed Central

    Burkhardt, D.; Taylor, T. K. F.; Dillon, C. T.; Read, R.; Cake, M.; Little, C. B.

    2009-01-01

    The study design included a multidisciplinary examination of the mineral phase of ovine intervertebral disc calcifications. The objective of the study was to investigate the mineral phase and its mechanisms of formation/association with degeneration in a naturally occurring animal model of disc calcification. The aetiology of dystrophic disc calcification in adult humans is unknown, but occurs as a well-described clinical disorder with hydroxyapatite as the single mineral phase. Comparable but age-related pathology in the sheep could serve as a model for the human disorder. Lumbar intervertebral discs (n = 134) of adult sheep of age 6 years (n = 4), 8 years (n = 12) and 11 years (n = 2) were evaluated using radiography, morphology, scanning and transmission electron microscopy, energy dispersive X-ray spectroscopy, X-ray powder diffraction, histology, immunohistology and proteoglycan analysis. Half of the 6-year, 84% of the 8-year and 86% of the 11-year-old discs had calcific deposits. These were not well delineated by plain radiography. They were either: (a) punctate deposits in the outer annulus, (b) diffuse deposits in the transitional zone or inner annulus fibrosus with occasional deposits in the nucleus, or (c) large deposits in the transitional zone extending variably into the nucleus. Their maximal incidence was in the lower lumbar discs (L4/5–L6/7) with no calcification seen in the lumbosacral or lower thoracic discs. All deposits were hydroxyapatite with large crystallite sizes (800–1,300 Å) compared to cortical bone (300–600 Å). No type X-collagen, osteopontin or osteonectin were detected in calcific deposits, although positive staining for bone sialoprotein was evident. Calcified discs had less proteoglycan of smaller hydrodynamic size than non-calcified discs. Disc calcification in ageing sheep is due to hydroxyapatite deposition. The variable, but large, crystal size and lack of protein markers indicate that this does not occur by an endochondral ossification-like process. The decrease in disc proteoglycan content and size suggests that calcification may precede or predispose to disc degeneration in ageing sheep. PMID:19165512

  14. Electromagnetic Levitation of a Disc

    ERIC Educational Resources Information Center

    Valle, R.; Neves, F.; de Andrade, R., Jr.; Stephan, R. M.

    2012-01-01

    This paper presents a teaching experiment that explores the levitation of a disc of ferromagnetic material in the presence of the magnetic field produced by a single electromagnet. In comparison to the classical experiment of the levitation of a sphere, the main advantage of the proposed laboratory bench is that the uniform magnetic field…

  15. Synthesis and Characteristics of Protective Coating on Thin Cover Layer for High Density-Digital Versatile Disc

    NASA Astrophysics Data System (ADS)

    Chang, Dohoon; Yoon, Duseop; Ro, Myongdo; Hwang, Inoh; Park, Insik; Shin, Dongho

    2003-02-01

    This study relates to the optical disc used in the high-density digital versatile disc (HD-DVD) system that uses a high numerical aperture of 0.85 at 405 nm wavelength. The disc has a protective layer formed on the light-incident surface for protection against damage and dust. The synthesis of the UV-curable resinous material, as means of making a protective layer within sufficient margins of thickness variation and optical and mechanical properties, was investigated. In addition, the dynamic characteristics, including reflectivity, fluctuation of the RF signal and noise level, were also investigated.

  16. Slim accretion discs: a model for ADAF-SLE transitions

    E-print Network

    I. V. Igumenshchev; M. A. Abramowicz; I. D. Novikov

    1997-09-16

    We numerically construct slim, global, vertically integrated models of optically thin, transonic accretion discs around black holes, assuming a regularity condition at the sonic radius and boundary conditions at the outer radius of the disc and near the black hole. In agreement with several previous studies, we find two branches of shock-free solutions, in which the cooling is dominated either by advection, or by local radiation. We also confirm that the part of the accretion flow where advection dominates is in some circumstances limited in size: it does not extend beyond a certain outer limiting radius. New results found in our paper concern the location of the limiting radius and properties of the flow near to it. In particular, we find that beyond the limiting radius, the advective dominated solutions match on to Shapiro, Lightman & Eardley (SLE) discs through a smooth transition region. Therefore, the full global solutions are shock-free and unlimited in size. There is no need for postulating an extra physical effect (e.g. evaporation) for triggering the ADAF-SLE transition. It occurs due to standard accretion processes described by the classic slim disc equations.

  17. Note: Light ageing with simultaneous colorimetry via fibre optics reflection spectrometry

    NASA Astrophysics Data System (ADS)

    ?ojewski, Tomasz; Thomas, Jacob; Go?ab, Roman; Kawa?ko, Jakub; ?ojewska, Joanna

    2011-07-01

    In this article, the design and characteristics of a micro-fadeometer is presented. The technique allows for a non-(micro-) destructive evaluation of the light fastness of colorants on various materials and can be used to directly assess valuable materials, such as heritage objects, and develop safer display strategies to promote their preservation. The presented instrument has several benefits over standard light ageing methods - low operating cost, non-damaging, real time measurement of induced changes for kinetics studies, and automated high throughput screening of materials. A selection of data is presented to demonstrate the flexibility of the presented instrument and illustrate how it can be used to evaluate museum lighting and oxygen-free display of heritage objects.

  18. Evolution of linear warps in accretion discs and applications to protoplanetary discs in binaries

    NASA Astrophysics Data System (ADS)

    Foucart, Francois; Lai, Dong

    2014-12-01

    Warped accretion discs are expected in many protostellar binary systems. In this paper, we study the long-term evolution of disc warp and precession for discs with dimensionless thickness H/r larger than their viscosity parameter ?, such that bending waves can propagate and dominate the warp evolution. For small warps, these discs undergo approximately rigid-body precession. We derive analytical expressions for the warp/twist profiles of the disc and the alignment time-scale for a variety of models. Applying our results to circumbinary discs, we find that these discs align with the orbital plane of the binary on a time-scale comparable to the global precession time of the disc, and typically much smaller than its viscous time-scale. We discuss the implications of our finding for the observations of misaligned circumbinary discs (such as KH 15D) and circumbinary planetary systems (such as Kepler-413); these observed misalignments provide useful constraints on the uncertain aspects of the disc warp theory. On the other hand, we find that circumstellar discs can maintain large misalignments with respect to the plane of the binary companion over their entire lifetime. We estimate that inclination angles larger than ˜20° can be maintained for typical disc parameters. Overall, our results suggest that while highly misaligned circumstellar discs in binaries are expected to be common, such misalignments should be rare for circumbinary discs. These expectations are consistent with current observations of protoplanetary discs and exoplanets in binaries, and can be tested with future observations.

  19. The Absolute Age of the Globular Cluster M15 Using Near-infrared Adaptive Optics Images from PISCES/LBT.

    NASA Astrophysics Data System (ADS)

    Monelli, M.; Testa, V.; Bono, G.; Ferraro, I.; Iannicola, G.; Fiorentino, G.; Arcidiacono, C.; Massari, D.; Boutsia, K.; Briguglio, R.; Busoni, L.; Carini, R.; Close, L.; Cresci, G.; Esposito, S.; Fini, L.; Fumana, M.; Guerra, J. C.; Hill, J.; Kulesa, C.; Mannucci, F.; McCarthy, D.; Pinna, E.; Puglisi, A.; Quiros-Pacheco, F.; Ragazzoni, R.; Riccardi, A.; Skemer, A.; Xompero, M.

    2015-10-01

    We present deep near-infrared J, {K}{{s}} photometry of the old, metal-poor Galactic globular cluster M15 obtained with images collected with the LUCI1 and PISCES cameras available at the Large Binocular Telescope (LBT). We show how the use of First Light Adaptive Optics (FLAO) system coupled with the PISCES camera allows us to improve the limiting magnitude by ˜2 mag in {K}{{s}}. By analyzing archival Hubble Space Telescope data, we demonstrate that the quality of the LBT/PISCES color-magnitude diagram is fully comparable with analogous space-based data. The smaller field of view is balanced by the shorter exposure time required to reach a similar photometric limit. We investigated the absolute age of M15 by means of two methods: (i) by determining the age from the position of the main-sequence turnoff (MSTO), and (ii) by the magnitude difference between the MSTO and the well-defined knee detected along the faint portion of the MS. We derive consistent values of the absolute age of M15, that is, 12.9 ± 2.6 Gyr and 13.3 ± 1.1 Gyr, respectively. Observations were carried out using the Large Binocular Telescope at Mount Graham, AZ. The LBT is an international collaboration among institutions in the United States, Italy, and Germany. LBT Corporation partners are the University of Arizona on behalf of the Arizona university system; Istituto Nazionale di Astrofisica, Italy; LBT Beteiligungsgesellschaft, Germany, representing the Max-Planck Society, the Astrophysical Institute Potsdam, and Heidelberg University; the Ohio State University; and the Research Corporation, on behalf of the University of Notre Dame, University of Minnesota, and University of Virginia.

  20. The clinical study of percutaneous disc decompression of treating herniation of cervical disc with Nd:YAG laser

    NASA Astrophysics Data System (ADS)

    Zhang, Dianxue; Cheng, Hefu; Wang, Jindong

    2005-07-01

    Objective: The possibility of PLDD (percutaneous laser disc decompression) and an ideal non-operative method which is long everlasting effect for PLDD was investigated. Methods: 159 patients of Cervical Disc Herniation with PLDD were studied. All the herniated discs were irradiated with 10­15J/S Nd:YAG laser quantum through optical-fiber under the supervision of C-arm X-ray. Results: All the patients were followed and reexamined CT or MRI after one to six months of PLDD. The result of cured (67.92%), excellent (24.53%), moderation (5.66%), non-effect (1.88%) was got. The excellent rate was 88.24%. The effective rate was 97.65%. Non-effective rate was 2.35%. Conclusion: When irradiated with Nd:YAG laser, the nucleus pulposus was vapouring, charring and coagulating. The volume and inner-pressure of the disc decreased. So the symptoms and signs improved. The main value of this methods were micro-damage, non-operation, no bleeding, no bone injury, good therapy effect, quick recovery, lesser pain, safety and excellent long everlasting effect. It is an ideal non-operative method of treating PLDD.

  1. On the age vs depth and optical clarity of deep ice at South Pole

    E-print Network

    The AMANDA collaboration

    1995-01-23

    The first four strings of phototubes for the AMANDA high-energy neutrino observatory are now frozen in place at a depth of 800 to 1000 m in ice at the South Pole. During the 1995-96 season an additional six strings will be deployed at greater depths. Provided absorption, scattering, and refraction of visible light are sufficiently small, the trajectory of a muon into which a neutrino converts can be determined by using the array of phototubes to measure the arrival times of \\v{C}erenkov light emitted by the muon. To help in deciding on the depth for implantation of the six new strings, we discuss models of age vs depth for South Pole ice, we estimate mean free paths for scattering from bubbles and dust as a function of depth, and we assess distortion of light paths due to refraction at crystal boundaries and interfaces between air-hydrate inclusions and normal ice. We conclude that the depth interval 1600 to 1800 m will be suitably transparent for the next six AMANDA strings and, moreover, that the interval 1600 to 2100 m will be suitably transparent for a future 1-km$^3$ observatory except possibly in a region a few tens of meters thick at a depth corresponding to a peak in the dust concentration at 60 kyr BP.

  2. Effect of phlorizin on sugar uptake by broadbean leaf discs. [Vica faba L

    SciTech Connect

    Lemoine, R.; Delrot, S.

    1986-04-01

    Phlorizin is a competitive inhibitor of Na/sup +//glucose symport in animal cells and of H/sup +//3-O-methylglucose (3-O-MeG) symport in liverworts. The effects of this compound on the uptake of (U-/sup 14/C) sucrose and of (/sup 14/C) 3-O-MeG by broadbean (Vicia faba L.) leaf discs were studied. Leaf discs without lower epidermis were preincubated in the dark for 30 min (fresh discs) or for 12 h (aged discs) on a medium buffered at pH 5.0 containing mannitol as an osmoticum. They were then incubated for 30 min in the light on a similar solution added with 1 mM (/sup 14/C) sucrose or (/sup 14/C) 3-O-MeG and 5 mM phlorizin. Phlorizin inhibited uptake of 3-O-MeG by 37 and 50% respectively in fresh and aged discs. Sucrose uptake was more sensitive to the inhibitor than 3-O-MeG uptake and was also more inhibited in aged than in fresh discs (76% inhibition vs 54%). Kinetic studies showed that the inhibition exerted by phlorizin in fresh material is of competitive type both for sucrose and for 3-O-MeG uptake. Electrophysiological measurements indicated that the inhibitor did not affect the transmembrane potential difference of parenchyma cells within 30 min. The data suggest that phlorizin can be recognized by the hexose and by the sucrose carrier of leaf cells.

  3. Searching for signatures of planet formation in stars with circumstellar debris discs

    NASA Astrophysics Data System (ADS)

    Maldonado, J.; Eiroa, C.; Villaver, E.; Montesinos, B.; Mora, A.

    2015-07-01

    Context. Tentative correlations between the presence of dusty circumstellar debris discs and low-mass planets have recently been presented. In parallel, detailed chemical abundance studies have reported different trends between samples of planet and non-planet hosts. Whether these chemical differences are indeed related to the presence of planets is still strongly debated. Aims: We aim to test whether solar-type stars with debris discs show any chemical peculiarity that could be related to the planet formation process. Methods: We determine in a homogeneous way the metallicity, [Fe/H], and abundances of individual elements of a sample of 251 stars including stars with known debris discs, stars harbouring simultaneously debris discs and planets, stars hosting exclusively planets, and a comparison sample of stars without known discs or planets. High-resolution échelle spectra (R ~ 57 000) from 2-3 m class telescopes are used. Our methodology includes the calculation of the fundamental stellar parameters (Teff, log g, microturbulent velocity, and metallicity) by applying the iron ionisation and equilibrium conditions to several isolated Fe i and Fe ii lines, as well as individual abundances of C, O, Na, Mg, Al, Si, S, Ca, Sc, Ti, V, Cr, Mn, Co, Ni, Cu, and Zn. Results: No significant differences have been found in metallicity, individual abundances or abundance-condensation temperature trends between stars with debris discs and stars with neither debris nor planets. Stars with debris discs and planets have the same metallicity behaviour as stars hosting planets, and they also show a similar ?[ X/Fe ] ? - TC trend. Different behaviour in the ?[ X/Fe ] ? - TC trends is found between the samples of stars without planets and the samples of planet hosts. In particular, when considering only refractory elements, negative slopes are shown in cool giant planet hosts, whilst positive ones are shown in stars hosting low-mass planets. The statistical significance of the derived slopes is low, however, probably because of the wide range of stellar parameters of our samples. Stars hosting exclusively close-in giant planets behave in a different way, showing higher metallicities and positive ?[ X/Fe ] ? - TC slope. A search for correlations between the ?[ X/Fe ] ? - TC slopes and the stellar properties reveals a moderate but significant correlation with the stellar radius and a weak correlation with the stellar age, which remain even if Galactic chemical evolution effects are considered. No correlation between the ?[ X/Fe ] ? - TC slopes and the disc/planet properties are found. Conclusions: The fact that stars with debris discs and stars with low-mass planets do not show either metal enhancement or a different ?[ X/Fe ] ? - TC trend might indicate a correlation between the presence of debris discs and the presence of low-mass planets. We extend results from previous works based mainly on solar analogues with reported differences in the ?[ X/Fe ] ? - TC trends between planet hosts and non-hosts to a wider range of parameters. However, these differences tend to be present only when the star hosts a cool distant planet and not in stars hosting exclusively low-mass planets. The interpretation of these differences as a signature of planetary formation should be considered with caution since moderate correlations between the TC-slopes with the stellar radius and the stellar age are found, suggesting that an evolutionary effect might be at work. Based on observations collected at the Centro Astronómico Hispano Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC); observations made with the Italian Telescopio Nazionale Galileo (TNG) operated on the island of La Palma by the Fundación Galileo Galilei of the INAF (Istituto Nazionale di Astrofisica); observations made with the Nordic Optical Telescope, operated on the island of La Palma jointly by Denmark, Finland, Iceland, Norway, and Sweden, in the Spanish Observatorio del R

  4. Synthetic NLTE accretion disc spectra for the dwarf nova SS Cyg during an outburst cycle

    E-print Network

    M. Kromer; T. Nagel; K. Werner

    2007-09-04

    Dwarf nova outbursts result from enhanced mass transport through the accretion disc of a cataclysmic variable system. We assess the question of whether these outbursts are caused by an enhanced mass transfer from the late-type main sequence star onto the white dwarf (so-called mass transfer instability model, MTI) or by a thermal instability in the accretion disc (disc instability model, DIM). We compute non-LTE models and spectra of accretion discs in quiescence and outburst and construct spectral time sequences for discs over a complete outburst cycle. We then compare our spectra to published optical spectroscopy of the dwarf nova SS Cygni. In particular, we investigate the hydrogen and helium line profiles that are turning from emission into absorption during the rise to outburst. The evolution of the hydrogen and helium line profiles during the rise to outburst and decline clearly favour the disc-instability model. Our spectral model sequences allow us to distinguish inside-out and outside-in moving heating waves in the disc of SS Cygni, which can be related to symmetric and asymmetric outburst light curves, respectively.

  5. Inward radial transport in differentially rotated plasma discs formed in z-pinch experiments

    NASA Astrophysics Data System (ADS)

    Lebedev, Sergey; Bennett, M.; Swadling, G. F.; Suttle, L.; Blackman, E.; Burdiak, G.; Chittenden, J. P.; Ciardi, A.; Drake, R. P.; Frank, A.; Hall, G. N.; Hare, J.; Patankar, S.; Smith, R. A.; Suzuki-Vidal, F.

    2014-10-01

    We will present experimental results showing the development of instabilities and an inward transport of matter in a differentially rotating supersonic plasma disc with dimensionless parameters relevant to modeling physics of astrophysical discs. The converging off-axis plasma flow forming the disc is produced by ablation of wires in a cylindrical wire array z-pinch (1.4 MA, 250 ns) combined with a cusp magnetic field, and the rotating disc is supported in equilibrium by the ram pressure of the flow. The radial profile of rotation velocity in the disc is measured using Doppler shifts of the ion feature of Thomson scattering spectra, while the broadening of the spectra yields the plasma temperature. The evolution of the disc structure is observed with multi-frame XUV and optical cameras, and the plasma density is measured using end-on laser interferometry. The Reynolds number in the disc is sufficiently large (>105) to allow development of turbulence on the time-scale of the experiment, and the observed inward transport of matter with the growth of small scale structures suggests that turbulence is responsible for the transport.

  6. Factors regulating viable cell density in the intervertebral disc: blood supply in relation to disc height

    PubMed Central

    Boubriak, Olga A; Watson, Natasha; Sivan, Sarit S; Stubbens, Naomi; Urban, Jill P G

    2013-01-01

    The intervertebral disc is an avascular tissue, maintained by a small population of cells that obtain nutrients mainly by diffusion from capillaries at the disc–vertebral body interface. Loss of this nutrient supply is thought to lead to disc degeneration, but how nutrient supply influences viable cell density is unclear. We investigated two factors that influence nutrient delivery to disc cells and hence cell viability: disc height and blood supply. We used bovine caudal discs as our model as these show a gradation in disc height. We found that although disc height varied twofold from the largest to the smallest disc studied, it had no significant effect on cell density, unlike the situation found in articular cartilage. The density of blood vessels supplying the discs was markedly greater for the largest disc than the smallest disc, as was the density of pores allowing capillary penetration through the bony endplate. Results indicate that changes in blood vessels in the vertebral bodies supplying the disc, as well as changes in endplate architecture appear to influence density of cells in intervertebral discs. PMID:23311982

  7. The pseudo-photosphere model for the continuum emission of gaseous discs

    NASA Astrophysics Data System (ADS)

    Vieira, R. G.; Carciofi, A. C.; Bjorkman, J. E.

    2015-12-01

    We investigate the continuum emission of viscous decretion discs around Be stars in this paper. The results obtained from non-LTE (local thermodynamic equilibrium) radiative transfer models show two regimes in the disc surface brightness profile: an inner optically thick region, which behaves as a pseudo-photosphere with a wavelength-dependent size, and an optically thin tenuous outer part, which contributes with about a third of the total flux. The isophotal shape of the surface brightness is well described by elliptical contours with an axial ratio b/a = cos i for inclinations i < 75°. Based on these properties, a semi-analytical model was developed to describe the continuum emission of gaseous discs. It provides fluxes and spectral slopes at the infrared within an accuracy of 10 and 5 per cent, respectively, when compared to the numerical results. The model indicates that the infrared spectral slope is mainly determined by both the density radial slope and the disc flaring exponent, being practically independent of disc inclination and base density. As a first application, the density structure of 15 Be stars was investigated, based on the infrared flux excess, and the results compared to previous determinations in the literature. Our results indicate that the decretion rates are in the range of 10-12-10-9 M? yr-1, which is at least two orders of magnitude smaller than the previous outflowing disc model predictions.

  8. X-ray and multiwavelength insights into the inner structure of high-luminosity disc-like emitters

    NASA Astrophysics Data System (ADS)

    Luo, B.; Brandt, W. N.; Eracleous, M.; Wu, Jian; Hall, P. B.; Rafiee, A.; Schneider, D. P.; Wu, Jianfeng

    2013-02-01

    We present X-ray and multiwavelength studies of a sample of eight high-luminosity active galactic nuclei (AGN) with disc-like H? emission-line profiles selected from the Sloan Digital Sky Survey Data Release 7. These sources have higher redshift (z ? 0.6) than the majority of the known disc-like emitters, and they occupy a largely unexplored space in the luminosity-redshift plane. Seven sources have typical AGN X-ray spectra with power-law photon indices of ? ? 1.4-2.0; two of them show some X-ray absorption (column density NH ? 1021-1022 cm-2 for neutral gas). The other source, J0850+4451, has only three hard X-ray photons detected and is probably heavily obscured (NH ? 3 × 1023 cm-2). This object is also identified as a low-ionization broad absorption line (BAL) quasar based on Mg II ?2799 absorption; it is the first disc-like emitter reported that is also a BAL quasar. The infrared-to-ultraviolet (UV) spectral energy distributions (SEDs) of these eight sources are similar to the mean SEDs of typical quasars with a UV `bump', suggestive of standard accretion discs radiating with high efficiency, which differs from low-luminosity disc-like emitters. Studies of the X-ray-to-optical power-law slope parameters (?OX) indicate that there is no significant excess X-ray emission in these high-luminosity disc-like emitters. Energy budget analysis suggests that for disc-like emitters in general, the inner disc must illuminate and ionize the outer disc efficiently (?15 per cent of the nuclear ionizing radiation is required on average) via direct illumination and/or scattering. Warped accretion discs are probably needed for direct illumination to work in high-luminosity objects, as their geometrically thin inner discs decrease the amount of direct illumination possible for a flat disc.

  9. Anisotropic radiation from accretion disc coronae in active galactic nuclei

    NASA Astrophysics Data System (ADS)

    Xu, Ya-Di

    2015-05-01

    In the unification scheme for active galactic nuclei, type 1 Seyfert galaxies and type 2 Seyfert galaxies are thought to be intrinsically the same but viewed at different angles. However, the Fe K? emission line luminosity of type 1 Seyfert galaxies was found on average to be about twice that of type 2 Seyfert galaxies for a given X-ray continuum luminosity in previous work. We construct an accretion disc-corona model in which a fraction of the energy dissipated in the disc is extracted to heat the corona above the disc. The radiation transfer equation with Compton scattering processes is an integro-differential equation, which is solved numerically for the corona with a parallel plane geometry. We find that the specific intensity of X-ray radiation from the corona changes little with the viewing angle ? when ? is small (nearly face-on), and it is sensitive to ? if the viewing angle is large (? ? 40°). The radiation from the cold disc, mostly in infrared, optical and UV bands, is almost proportional to cos ? when ? ? 40°, while it decreases more rapidly than cos ? when ? ? 40° because of strong absorption in the corona in this case. For Seyfert galaxies, the Fe K? line may probably be emitted from the disc irradiated by the X-ray continuum emission. The observed equivalent width difference between type 1 Seyfert galaxies and type 2 Seyfert galaxies can be reproduced by our model calculations, provided the type 1 Seyfert galaxies are observed nearly face-on and the average inclination angle of type 2 Seyfert galaxies is ˜65°.

  10. Evolution of Accretion Discs around a Kerr Black Hole using Extended Magnetohydrodynamics

    E-print Network

    Foucart, Francois; Gammie, Charles F; Quataert, Eliot

    2015-01-01

    Black holes accreting well below the Eddington rate are believed to have geometrically thick, optically thin, rotationally supported accretion discs in which the Coulomb mean free path is large compared to $GM/c^2$. In such an environment, the disc evolution may differ significantly from ideal magnetohydrodynamic predictions. We present non-ideal global axisymmetric simulations of geometrically thick discs around a rotating black hole. The simulations are carried out using a new code ${\\rm\\it grim}$, which evolves a covariant extended magnetohydrodynamics model derived by treating non-ideal effects as a perturbation of ideal magnetohydrodynamics. Non-ideal effects are modeled through heat conduction along magnetic field lines, and a difference between the pressure parallel and perpendicular to the field lines. The model relies on an effective collisionality in the disc from wave-particle scattering and velocity-space (mirror and firehose) instabilities. We find that the pressure anisotropy grows to match the ...

  11. Eddy current braking experiment using brake disc from aluminium series of A16061 and A17075

    NASA Astrophysics Data System (ADS)

    Baharom, M. Z.; Nuawi, M. Z.; Priyandoko, G.; Harris, S. M.

    2012-09-01

    The electromagnetic braking using eddy current was studied, focused on two series of aluminium as the brake disc which are A16061 and A17075. This paper presents the comparison for both series in a few varied parameters related to eddy current braking such as air-gap, number of turns and brake disc thickness. Optical tachometer has been used along with PULSE analyzer to capture the speed (rpm) and time (s). The findings shows that the smaller the air-gap, the larger of electromagnet turns and the thicker disc thickness is, will generate higher braking torque to stop the rotational motion of disc brake and give great performance for eddy current braking. Thos parameters that been evaluated also addressed a potential on expanding this knowledge to develop an electromagnetic braking system to replace the conventional braking system.

  12. Grain charging in protoplanetary discs

    E-print Network

    Ilgner, Martin

    2011-01-01

    Recent work identified a growth barrier for dust coagulation that originates in the electric repulsion between colliding particles. Depending on its charge state, dust material may have the potential to control key processes towards planet formation such as MHD (magnetohydrodynamic) turbulence and grain growth which are coupled in a two-way process. We quantify the grain charging at different stages of disc evolution and differentiate between two very extreme cases: compact spherical grains and aggregates with fractal dimension D_f = 2. Applying a simple chemical network that accounts for collisional charging of grains, we provide a semi-analytical solution. This allowed us to calculate the equilibrium population of grain charges and the ionisation fraction efficiently. The grain charging was evaluated for different dynamical environments ranging from static to non-stationary disc configurations. The results show that the adsorption/desorption of neutral gas-phase heavy metals, such as magnesium, effects the ...

  13. Laminated composite disc flywheel development

    NASA Astrophysics Data System (ADS)

    Nimmer, R. P.; Torossian, K.; Hickey, J.

    1980-02-01

    A flywheel concept for an electric powered vehicle uses a laminated disc and a filament wound outer ring assembled with an interference fit between these two components. The laminated, central disc is made of S2-glass-epoxy and the outer ring is filament-wound graphite-epoxy. Projections for this particular flywheel design indicate that it will be both practical and relatively inexpensive to produce, and that it will have a high energy density capacity. Two hybrid composite flywheels of 37 cm O.D. were successfully assembled. The spin test data are summarized, the nondestructive test dat are discussed and the fabrication techniques developed for the hybrid flywheel assembly are described.

  14. Ptolemy relations for punctured discs

    E-print Network

    Baur, Karin

    2007-01-01

    We construct frieze patterns of type D_N with entries which are numbers of matchings between vertices and triangles of corresponding triangulations of a punctured disc. For triangulations corresponding to orientations of the Dynkin diagram of type D_N, we show that the numbers in the pattern can be interpreted as specialisations of cluster variables in the corresponding Fomin-Zelevinsky cluster algebra.

  15. On the thermal stability of transonic accretion discs

    E-print Network

    Ewa Szuszkiewicz; John C. Miller

    1997-01-13

    Nonlinear time-dependent calculations have been carried out in order to study the evolution of the thermal instability for optically thick, transonic, slim accretion discs around black holes. In the present calculations we have investigated only the original version of the slim disc model with low viscosity. This version does not yet contain several important non-local effects but our aim is to use it as a standard reference against which to compare the results from forthcoming studies in which additional effects will be added one by one thus giving a systematic way of understanding the contribution from each of them. A range of results for different cases is presented showing a number of interesting features. One preliminary conclusion is that the stabilizing effect of advection seems not to be strong enough in these low viscosity models to allow for limit cycle behaviour to occur.

  16. Proto-planetary disc evolution and dispersal

    NASA Astrophysics Data System (ADS)

    Rosotti, Giovanni Pietro

    2015-05-01

    Planets form from gas and dust discs in orbit around young stars. The timescale for planet formation is constrained by the lifetime of these discs. The properties of the formed planetary systems depend thus on the evolution and final dispersal of the discs, which is the main topic of this thesis. Observations reveal the existence of a class of discs called "transitional", which lack dust in their inner regions. They are thought to be the last stage before the complete disc dispersal, and hence they may provide the key to understanding the mechanisms behind disc evolution. X-ray photoevaporation and planet formation have been studied as possible physical mechanisms responsible for the final dispersal of discs. However up to now, these two phenomena have been studied separately, neglecting any possible feedback or interaction. In this thesis we have investigated what is the interplay between these two processes. We show that the presence of a giant planet in a photo-evaporating disc can significantly shorten its lifetime, by cutting the inner regions from the mass reservoir in the exterior of the disc. This mechanism produces transition discs that for a given mass accretion rate have larger holes than in models considering only X-ray photo-evaporation, constituting a possible route to the formation of accreting transition discs with large holes. These discs are found in observations and still constitute a puzzle for the theory. Inclusion of the phenomenon called "thermal sweeping", a violent instability that can destroy a whole disc in as little as 10 4 years, shows that the outer disc left can be very short-lived (depending on the X-ray luminosity of the star), possibly explaining why very few non accreting transition discs are observed. However the mechanism does not seem to be efficient enough to reconcile with observations. In this thesis we also show that X-ray photo-evaporation naturally explains the observed correlation between stellar masses and accretion rates and is therefore the ideal candidate for driving disc evolution. Another process that can influence discs is a close encounter with another star. In this thesis we develop a model to study the effect of stellar dynamics in the natal stellar cluster on the discs, following for the first time at the same time the stellar dynamics together with the evolution of the discs. We find that, although close encounters with stars are unlikely to change significantly the mass of a disc, they can change substantially its size, hence imposing an upper limit on the observed disc radii. Finally, we investigated in this thesis whether discs can be reformed after their dispersal. If a star happens to be in a region that is currently forming stars, it can accrete material from the interstellar medium. This mechanism may result in the production of "second generation" discs such that in a given star forming region a few percent of stars may still possess a disc, in tentative agreement with observations of so called "old accretors", which are difficult to explain within the current paradigm of disc evolution and dispersal.

  17. Optical ages indicate the southwestern margin of the Green Bay Lobe in Wisconsin, USA, was at its maximum extent until about 18,500 years ago

    USGS Publications Warehouse

    Attig, J.W.; Hanson, P.R.; Rawling, J.E.; Young, A.R.; Carson, E.C.

    2011-01-01

    Samples for optical dating were collected to estimate the time of sediment deposition in small ice-marginal lakes in the Baraboo Hills of Wisconsin. These lakes formed high in the Baraboo Hills when drainage was blocked by the Green Bay Lobe when it was at or very near its maximum extent. Therefore, these optical ages provide control for the timing of the thinning and recession of the Green Bay Lobe from its maximum position. Sediment that accumulated in four small ice-marginal lakes was sampled and dated. Difficulties with field sampling and estimating dose rates made the interpretation of optical ages derived from samples from two of the lake basins problematic. Samples from the other two lake basins-South Bluff and Feltz basins-responded well during laboratory analysis and showed reasonably good agreement between the multiple ages produced at each site. These ages averaged 18.2. ka (n= 6) and 18.6. ka (n= 6), respectively. The optical ages from these two lake basins where we could carefully select sediment samples provide firm evidence that the Green Bay Lobe stood at or very near its maximum extent until about 18.5. ka.The persistence of ice-marginal lakes in these basins high in the Baraboo Hills indicates that the ice of the Green Bay Lobe had not experienced significant thinning near its margin prior to about 18.5. ka. These ages are the first to directly constrain the timing of the maximum extent of the Green Bay Lobe and the onset of deglaciation in the area for which the Wisconsin Glaciation was named. ?? 2011 Elsevier B.V.

  18. In Vivo Measurement of Age-Related Stiffening in the Crystalline Lens by Brillouin Optical Microscopy

    PubMed Central

    Scarcelli, Giuliano; Kim, Pilhan; Yun, Seok Hyun

    2011-01-01

    Abtract The biophysical and biomechanical properties of the crystalline lens (e.g., viscoelasticity) have long been implicated in accommodation and vision problems, such as presbyopia and cataracts. However, it has been difficult to measure such parameters noninvasively. Here, we used in vivo Brillouin optical microscopy to characterize material acoustic properties at GHz frequency and measure the longitudinal elastic moduli of lenses. We obtained three-dimensional elasticity maps of the lenses in live mice, which showed biomechanical heterogeneity in the cortex and nucleus of the lens with high spatial resolution. An in vivo longitudinal study of mice over a period of 2 months revealed a marked age-related stiffening of the lens nucleus. We found remarkably good correlation (log-log linear) between the Brillouin elastic modulus and the Young's modulus measured by conventional mechanical techniques at low frequencies (?1 Hz). Our results suggest that Brillouin microscopy is potentially useful for basic and animal research and clinical ophthalmology. PMID:21943436

  19. Magnetorotational instability in protoplanetary discs

    NASA Astrophysics Data System (ADS)

    Salmeron, Raquel; Wardle, Mark

    2005-07-01

    We investigate the linear growth and vertical structure of the magnetorotational instability (MRI) in weakly ionized, stratified accretion discs. The magnetic field is initially vertical and dust grains are assumed to have settled towards the mid-plane, so charges are carried by electrons and ions only. Solutions are obtained at representative radial locations from the central protostar for different choices of the initial magnetic field strength, sources of ionization, disc structure and configuration of the conductivity tensor. The MRI is active over a wide range of magnetic field strengths and fluid conditions in low-conductivity discs. Moreover, no evidence was found of a low-limit field strength below which unstable modes do not exist. For the minimum-mass solar nebula model, incorporating cosmic ray ionization, perturbations grow at 1 au for B<~ 8 G. For a significant subset of these strengths (200mG <~B<~ 5G), the maximum growth rate is of the order of the ideal magnetohydrodynamic (MHD) rate (0.75?). Hall conductivity modifies the structure and growth rate of global unstable modes at 1 au for all magnetic field strengths that support MRI. As a result, at this radius, modes obtained with a full conductivity tensor grow faster and are active over a more extended cross-section of the disc than perturbations in the ambipolar diffusion limit. For relatively strong fields (e.g. B>~ 200 mG), ambipolar diffusion alters the envelope shapes of the unstable modes, which peak at an intermediate height, instead of being mostly flat as modes in the Hall limit are in this region of parameter space. Similarly, when cosmic rays are assumed to be excluded from the disc by the winds emitted by the magnetically active protostar, unstable modes grow at this radius for B<~ 2 G. For strong fields, perturbations exhibit a kink at the height where X-ray ionization becomes active. Finally, for R= 5 au (10 au), unstable modes exist for B<~ 800 mG (B<~ 250 mG) and the maximum growth rate is close to the ideal-MHD rate for 20 <~B<~ 500 mG (2 <~B<~ 50 mG). Similarly, perturbations incorporating Hall conductivity have a higher wavenumber and grow faster than solutions in the ambipolar diffusion limit for B<~ 100 mG (B<~ 10 mG). Unstable modes grow even at the mid-plane for B>~ 100 mG (B~ 1 mG), but for weaker fields, a small dead region exists. This study shows that, despite the low magnetic coupling, the magnetic field is dynamically important for a large range of fluid conditions and field strengths in protostellar discs. An example of such magnetic activity is the generation of MRI unstable modes, which are supported at 1 au for field strengths up to a few gauss. Hall diffusion largely determines the structure and growth rate of these perturbations for all studied radii. At radii of order 1 au, in particular, it is crucial to incorporate the full conductivity tensor in the analysis of this instability and more generally in studies of the dynamics of astrophysical discs.

  20. The imprint of satellite accretion on the chemical and dynamical properties of disc galaxies

    E-print Network

    Ruiz-Lara, T; Gibson, B K; Pérez, I; Florido, E; Minchev, I; Sánchez-Blázquez, P

    2015-01-01

    Aims: We study the effects of the cosmological assembly history on the chemical and dynamical properties of the discs of spiral galaxies as a function of radius. Methods: We make use of the simulated Milky-Way mass, fully-cosmological discs, from {\\tt RaDES} (Ramses Disc Environment Study). We analyse their assembly history by examining the proximity of satellites to the galactic disc, instead of their merger trees, to better gauge which satellites impact the disc. We present stellar age and metallicity profiles, Age-Metallicity Relation (AMR), Age-Velocity dispersion Relation (AVR), and Stellar Age Distribution (SAD) in several radial bins for the simulated galaxies. Results: Assembly histories can be divided into three different stages: i) a merger dominated phase, when a large number of mergers with mass ratios of $\\sim$1:1 take place (lasting $\\sim$3.2$\\pm$0.4 Gyr on average); ii) a quieter phase, when $\\sim$1:10 mergers take place (lasting $\\sim$4.4$\\pm$2.0 Gyr) - these two phases are able to kinematical...

  1. Immunolocalization of Delta-Giardin within the Ventral Disc in of Trophozoites and in cysts of Giardia duodenalis using the Multiplex Laser Scanning Confocal Microscopy

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Immunolocalization of alpha2-, beta- and delta-giardin in Giardia showed that in the trophozoites and cysts delta-giardin it strictly associated with the ventral disc. Optical sectioning of the ventral discs, together with quantitative colocalization of the immunoreactivity for delta- and beta-giard...

  2. On the theory of disc photoevaporation

    E-print Network

    Owen, James E; Ercolano, Barbara

    2011-01-01

    We discuss a hydrodynamical model for the dispersal of protoplanetary discs around young, low mass (100) luminosity ratios, the FUV constricts the X-ray flow and may dominate the mass-loss. Simulations of low mass discs with inner holes demonstrate a further stage of disc clearing, which we call `thermal sweeping'. This process occurs when the mid-plane pressure drops to sufficiently low values. At this stage a bound, warm, X-ray heated region becomes sufficiently large and unstable, such that the remaining disc material is cleared on approximately dynamical time-scales. This process significantly reduces the time taken to clear the outer regions of the disc, resulting in an expected transition disc population that will be dominated by accreting objects, as indicated by recent observations.

  3. Stirring in massive, young debris discs from spatially resolved Herschel images

    NASA Astrophysics Data System (ADS)

    Moór, A.; Kóspál, Á.; Ábrahám, P.; Apai, D.; Balog, Z.; Grady, C.; Henning, Th.; Juhász, A.; Kiss, Cs.; Krivov, A. V.; Pawellek, N.; Szabó, Gy. M.

    2015-02-01

    A significant fraction of main-sequence stars are encircled by dusty debris discs, where the short-lived dust particles are replenished through collisions between planetesimals. Most destructive collisions occur when the orbits of smaller bodies are dynamically stirred up, either by the gravitational effect of locally formed Pluto-sized planetesimals (self-stirring scenario), or via secular perturbation caused by an inner giant planet (planetary stirring). The relative importance of these scenarios in debris systems is unknown. Here, we present new Herschel Space Observatory imagery of 11 discs selected from the most massive and extended known debris systems. All discs were found to be extended at far-infrared wavelengths, five of them being resolved for the first time. We evaluated the feasibility of the self-stirring scenario by comparing the measured disc sizes with the predictions of the model calculated for the ages of our targets. We concluded that the self-stirring explanation works for seven discs. However, in four cases, the predicted pace of outward propagation of the stirring front, assuming reasonable initial disc masses, was far too low to explain the radial extent of the cold dust. Therefore, for HD 9672, HD 16743, HD 21997, and HD 95086, another explanation is needed. We performed a similar analysis for ? Pic and HR 8799, reaching the same conclusion. We argue that planetary stirring is a promising possibility to explain the disc properties in these systems. In HR 8799 and HD 95086, we may already know the potential perturber, since their known outer giant planets could be responsible for the stirring process. Interestingly, the discs around HD 9672, HD 21997, and ? Pic are also unique in harbouring detectable amount of molecular CO gas. Our study demonstrates that among the largest and most massive debris discs self-stirring may not be the only active scenario, and potentially planetary stirring is responsible for destructive collisions and debris dust production in a number of systems.

  4. Kinematics and excitation of the molecular hydrogen accretion disc in NGC 1275

    NASA Astrophysics Data System (ADS)

    Scharwächter, J.; McGregor, P. J.; Dopita, M. A.; Beck, T. L.

    2013-03-01

    We report the results of high spatial and spectral resolution integral-field spectroscopy of the central ˜3 × 3 arcsec2 of the active galaxy NGC 1275 (Perseus A), based on observations with the Near-infrared Integral Field Spectrograph (NIFS) and the ALTitude conjugate Adaptive optics for the InfraRed (ALTAIR) adaptive-optics system on the Gemini North telescope. The circum-nuclear disc in the inner R ˜ 50 pc of NGC 1275 is seen in both the H2 and [Fe II] lines. The disc is interpreted as the outer part of a collisionally excited turbulent accretion disc. The kinematic major axis of the disc at a position angle of 68° is oriented perpendicular to the radio jet. A streamer-like feature to the south-west of the disc, detected in H2 but not in [Fe II], is discussed as one of possibly several molecular streamers, presumably falling into the nuclear region. Indications of an ionization structure within the disc are deduced from the He I and Br? emission lines, which may partially originate from the inner portions of the accretion disc. The kinematics of these two lines agrees with the signature of the circum-nuclear disc, but both lines display a larger central velocity dispersion than the H2 line. The ro-vibrational H2 transitions from the core of NGC 1275 are indicative of thermal excitation caused by shocks and agree with excitation temperatures of ˜1360 and ˜4290 K for the lower and higher energy H2 transitions, respectively. The data suggest X-ray heating as the dominant excitation mechanism of [Fe II] emission in the core, while fast shocks are a possible alternative. The [Fe II] lines indicate an electron density of ˜4000 cm-3. The H2 disc is modelled using simulated NIFS data cubes of H2 emission from inclined discs in Keplerian rotation around a central mass. Assuming a disc inclination of 45° ± 10°, the best-fitting models imply a central mass of (8 + 7 - 2) × 108 M?. Taken as a black hole mass estimate, this value is larger than previous estimates for the black hole mass in NGC 1275, but is in agreement with the M-? relation within the rms scatter. However, the molecular gas mass in the core region is tentatively estimated to be non-negligible, which suggests that the central mass may rather represent an upper limit for the black hole mass. In comparison to other H2-luminous radio galaxies, we discuss the relative role of jet feedback and accretion in driving shocks and turbulence in the molecular gas component.

  5. Immunohistochemical expression of collagen type IV antibody in the articular disc of the temporomandibular joint of human fetuses.

    PubMed

    de Moraes, Luís Otávio Carvalho; Lodi, Fábio Redivo; Gomes, Thiago Simão; Marques, Sergio Ricardo; Fernandes Junior, João Antão; Oshima, Celina Tizuko Fijiyama; Alonso, Luís Garcia

    2008-01-01

    The objective of this paper was to study the morphology of the articular disc and analyze the immunohistochemical expression of the marker of type IV collagen in the articular disc of the temporomandibular joint (TMJ) of human fetuses of different gestational ages. Twenty TMJ from human fetuses aging from 21 to 24 weeks of intrauterine life were studied. The TMJ were supplied by the Federal University of Uberaba. The ages of the fetuses were determined by measuring the crown-rump length (CRL). Macroscopically, the fetuses were fixed in a formalin solution at 10% and dissected by removing the skin and the subcutaneous tissue, exposing the deep structures. An immunohistochemical marker of type IV collagen was used in order to characterize the presence of blood vessels in the central region of the temporomandibular joint disc. Analysis of the immunohistochemical marker of type IV collagen showed the presence of blood vessels in the central region of the temporomandibular disc in human fetuses. PMID:18702236

  6. HD 98800: A most unusual debris disc

    E-print Network

    P. E. Verrier; N. W. Evans

    2008-07-31

    The dynamics of planetesimals in the circumbinary debris disc of the quadruple star system HD 98800 are investigated. Evolving a spherical shell of test particles from a million years ago to the present day indicates that both coplanar and retrograde warped discs could exist, as well as a high inclination halo of material. Significant gaps are seen in the discs, as well as unexpected regions of stability due to the retrograde nature of the stellar orbits. Despite a viewing angle almost perpendicular to the direction of the warp of the planetesimal disc it is still intersected by the line of sight for eccentricities of the outer orbit of 0.5 or less.

  7. On the evolution of the protolunar disc

    PubMed Central

    Ward, William R.

    2014-01-01

    The structure and viscous evolution of a post-impact, protolunar disc is examined. The equations for a silicate disc in two-phase (vapour–liquid) equilibrium are employed to derive an analytical solution to vertical structure. Both a vertically mixed phase disc and a stratified disc, where a magma layer exists in the mid-plane surrounded by a vapour reservoir, are considered. The former largely reproduces the low gas mass fraction, x?1, profiles of the disc described in earlier literature that proposed that the disc would hover on the brink of gravitational instability. In the latter, the vapour layer has x?1 and is generally gravitationally stable, while the magma layer is vigorously unstable. The viscous evolution of the stratified model is then explored. Initially, the disc quickly settles to a quasi-steady state with a vapour reservoir containing the majority of the disc mass. The magma layer viscously spreads on a time scale of approximately 3–4 years, during which vapour continuously condenses into droplets that settle to the mid-plane, maintaining the magma surface density in spite of disc spreading. Material flowing inwards is accreted by the Earth; material flowing outwards past the Roche boundary can become incorporated into accreting moonlets. This evolution persists until the vapour reservoir is depleted in approximately 50–100 years, depending on its initial mass. PMID:25114314

  8. Accretion Discs Show Their True Colours

    NASA Astrophysics Data System (ADS)

    2008-07-01

    Quasars are the brilliant cores of remote galaxies, at the hearts of which lie supermassive black holes that can generate enough power to outshine the Sun a trillion times. These mighty power sources are fuelled by interstellar gas, thought to be sucked into the hole from a surrounding 'accretion disc'. A paper in this week's issue of the journal Nature, partly based on observations collected with ESO's Very Large Telescope, verifies a long-standing prediction about the intensely luminous radiation emitted by these accretion discs. Uncovering the disc ESO PR Photo 21/08 Uncovering the inner disc "Astronomers were puzzled by the fact that the best models of these discs couldn't quite be reconciled with some of the observations, in particular, with the fact that these discs did not appear as blue as they should be," explains lead-author Makoto Kishimoto. Such a discrepancy could be the signal that there was something very wrong with the models. With his colleagues, he investigated this discrepancy by studying the polarised light from six quasars. This enabled them to demonstrate that the disc spectrum is as blue as predicted. "The crucial observational difficulty here has been that the disc is surrounded by a much larger torus containing hot dust, whose light partly outshines that of the disc," says Kishimoto. "Because the light coming from the disc is scattered in the disc vicinity and thus polarised, by observing only polarised light from the quasars, one can uncover the buried light from the disc." In a similar way that a fisherman would wear polarised sunglasses to help get rid of the glare from the water surface and allow him to see more clearly under the water, the filter on the telescope allowed the astronomers to see beyond surrounding clouds of dust and gas to the blue colour of the disc in infrared light. The observations were done with the FORS and ISAAC instruments on one of the 8.2-m Unit Telescopes of ESO's Very Large Telescope, located in the Atacama Desert, in Chile, as well as several other telescopes, including STFC's UKIRT. The standard picture of the accretion disc is therefore vindicated. The authors believe that further measurements could eventually provide valuable insight into how and where the disc ends, and how material is being supplied to the disc.

  9. Optical Coherence Tomography in Glaucoma

    NASA Astrophysics Data System (ADS)

    Berisha, Fatmire; Hoffmann, Esther M.; Pfeiffer, Norbert

    Retinal nerve fiber layer (RNFL) thinning and optic nerve head cupping are key diagnostic features of glaucomatous optic neuropathy. The higher resolution of the recently introduced SD-OCT offers enhanced visualization and improved segmentation of the retinal layers, providing a higher accuracy in identification of subtle changes of the optic disc and RNFL thinning associated with glaucoma.

  10. The pseudo-photosphere model for the continuum emission of gaseous discs

    E-print Network

    Vieira, Rodrigo G; Bjorkman, Jon E

    2015-01-01

    We investigate the continuum emission of viscous decretion discs around Be stars in this paper. The results obtained from non-LTE (local thermodynamic equilibrium) radiative transfer models show two regimes in the disc surface brightness profile: an inner optically thick region, which behaves as a pseudo-photosphere with a wavelength-dependent size, and an optically thin tenuous outer part, which contributes with about a third of the total flux. The isophotal shape of the surface brightness is well described by elliptical contours with an axial ratio $b/a=\\cos i$ for inclinations $iinfrared within an accuracy of $10\\%$ and $5\\%$, respectively, when compared to the numerical results. The model indicates that the infrared spectral slope is mainly determined by both the density radial slope and the disc flaring exponent, being practic...

  11. 8 Areas of Age-Related Change

    MedlinePLUS

    ... please turn Javascript on. Photo: PhotoDisc 1. Brain: Memory and Alzheimer's Disease (AD) As adults age, many ... Researchers from 12 institutions, including the NIH's National Human Genome Research Institute (NHGRI), recently announced the results ...

  12. Total Disc Replacement in Lumbar Degenerative Disc Diseases

    PubMed Central

    2015-01-01

    More than 10 years have passed since lumbar total disc replacement (LTDR) was introduced for the first time to the world market for the surgical management of lumbar degenerative disc disease (DDD). It seems like the right time to sum up the relevant results in order to understand where LTDR stands on now, and is heading forward to. The pathogenesis of DDD has been currently settled, but diagnosis and managements are still controversial. Fusion is recognized as golden standard of surgical managements but has various kinds of shortcomings. Lately, LTDR has been expected to replace fusion surgery. A great deal of LTDR reports has come out. Among them, more than 5-year follow-up prospective randomized controlled studies including USA IDE trials were expected to elucidate whether for LTDR to have therapeutic benefit compared to fusion. The results of these studies revealed that LTDR was not inferior to fusion. Most of clinical studies dealing with LTDR revealed that there was no strong evidence for preventive effect of LTDR against symptomatic degenerative changes of adjacent segment disease. LTDR does not have shortcomings associated with fusion. However, it has a potentiality of the new complications to occur, which surgeons have never experienced in fusion surgeries. Consequently, longer follow-up should be necessary as yet to confirm the maintenance of improved surgical outcome and to observe any very late complications. LTDR still may get a chance to establish itself as a substitute of fusion both nominally and virtually if it eases the concerns listed above. PMID:26713139

  13. Formation of massive stars and black holes in self-gravitating AGN discs, and gravitational waves in LISA band

    E-print Network

    Yuri Levin

    2003-07-04

    We propose a scenario in which massive stars form at the outer edges of an AGN accretion disc. We analyze the dynamics of a disc forming around a supermassive black hole, in which the angular momentum is transported by turbulence induced by the disc's self-gravity. We find that once the surface density of the disc exceeds a critical value, the disc fragments into dense clumps. The biggest clumps collapse and form massive stars, which produce few-tens-solar-mass black holes at the end of their evolution. The embedded black holes will interact gravitationally with the massive accretion disc and be dragged towards the central black hole. Merger of a disc-born black hole with the central black hole will produce a burst of gravitational waves. If the central black hole is accreting at a rate comparable to the Eddington limit, the gas drag from the accretion disc will not alter significantly the dynamics of the final year of merger, and the gravitational waves should be observable by LISA. We argue that for a reasonable range of parameters such mergers will be detected monthly, and that the gravitational-wave signal from these mergers is distinct from that of other merger scenarios. Also, for some plausible black hole masses and accretion rates, the burst of gravitational waves should be accompanied by a detectable change in the optical luminosity of the central engine.

  14. 21 CFR 872.3970 - Interarticular disc prosthesis (interpositional implant).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...Interarticular disc prosthesis (interpositional implant). 872.3970 Section 872.3970...Interarticular disc prosthesis (interpositional implant). (a) Identification. An interarticular disc prosthesis (interpositional implant) is a device that is intended to...

  15. Use NASA GES DISC Data in ArcGIS

    NASA Technical Reports Server (NTRS)

    Yang, Wenli; Pham, Long B.; Kempler, Steve

    2015-01-01

    This presentation describes GIS relevant data at NASA Goddard Earth Sciences Data and Information Services Center (GES DISC), GES DISC Services and Support for GIS Users, and use cases of GES DISC data in ArcGIS.

  16. Optical coherence tomography in photodynamic therapy for subfoveal choroidal neovascularisation secondary to age related macular degeneration: a cross sectional study

    PubMed Central

    Sahni, J; Stanga, P; Wong, D; Harding, S

    2005-01-01

    Aims: To introduce new terminology and validate its reliability for the analysis of optical coherence tomography (OCT) scans, compare clinical detection of cystoid macular oedema (CMO) and subretinal fluid (SRF) with OCT findings, and to study the effect of photodynamic therapy (PDT) on the foveal morphology. Methods: Patients with subfoveal, predominantly classic choroidal neovascularisation (CNV) secondary to age related macular degeneration (AMD) undergoing PDT were evaluated with refraction protocol best corrected logMAR visual acuity (VA), slit lamp biomicroscopy, stereoscopic fluorescein angiography (FFA), and OCT. New terminologies introduced to interpret the OCT scans were: neuroretinal foveal thickness (NFT), bilaminar foveal thickness (BFT), outer high reflectivity band thickness (OHRBT), intraretinal fluid (IRF), subretinal fluid (oSRF), and vitreomacular hyaloid attachment (VMHA). Results: Fifty six eyes of 53 patients were studied. VA was better in eyes with a thinner outer high reflectivity band (OHRBT) (p?=?0.02) and BFT (p?=?0.05). BFT was less in eyes that had undergone a greater number of PDT treatments (p?=?0.04). There was poor agreement between OCT and clinical examination in the detection of CMO and subretinal fluid (??=?0.289 and ??=?0.165 respectively). To validate the interpretation and measurements on OCT, two groups of 20 scans were analysed by two independent observers. There was good agreement between the observers in the detection of IRF, oSRF, and VMHA (p<0.001). Measurements of NFT and BFT had a high reproducibility, and of OHRBT reproducibility was low. Conclusions: New terminology has been introduced and tested. OCT appears to be superior to clinical examination and FFA in the detection of CMO. In this study, better vision was associated with a thinner OHRBT and/or the absence of SRF giving insight into the biological effect of PDT. PMID:15722312

  17. The Project MACULA Retinal Pigment Epithelium Grading System for Histology and Optical Coherence Tomography in Age-Related Macular Degeneration

    PubMed Central

    Zanzottera, Emma C.; Messinger, Jeffrey D.; Ach, Thomas; Smith, R. Theodore; Freund, K. Bailey; Curcio, Christine A.

    2015-01-01

    Purpose. To seek pathways of retinal pigment epithelium (RPE) fate in age-related macular degeneration via a morphology grading system; provide nomenclature, visualization targets, and metrics for clinical imaging and model systems. Methods. Donor eyes with geographic atrophy (GA) or choroidal neovascularization (CNV) and one GA eye with previous clinical spectral-domain optical coherence tomography (SDOCT) imaging were processed for histology, photodocumented, and annotated at predefined locations. Retinal pigment epithelial cells contained spindle-shaped melanosomes, apposed a basal lamina or basal laminar deposit (BLamD), and exhibited recognizable morphologies. Thicknesses and unbiased estimates of frequencies were obtained. Results. In 13 GA eyes (449 locations), ‘Shedding,’ ‘Sloughed,’ and ‘Dissociated’ morphologies were abundant; 22.2% of atrophic locations had ‘Dissociated’ RPE. In 39 CNV eyes (1363 locations), 37.3% of locations with fibrovascular/fibrocellular scar had ‘Entombed’ RPE; ‘Sloughed,’ ‘Dissociated,’ and ‘Bilaminar’ morphologies were abundant. Of abnormal RPE, CNV and GA both had ?35% ‘Sloughed’/‘Intraretinal,’ with more Intraretinal in CNV (9.5% vs. 1.8%). ‘Shedding’ cells associated with granule aggregations in BLamD. The RPE layer did not thin, and BLamD remained thick, with progression. Granule-containing material consistent with three morphologies correlated to SDOCT hyperreflective foci in the previously examined GA patient. Conclusions. Retinal pigment epithelium morphology indicates multiple pathways in GA and CNV. Atrophic/scarred areas have numerous cells capable of transcribing genes and generating imaging signals. Shed granule aggregates, possibly apoptotic, are visible in SDOCT, as are ‘Dissociated’ and ‘Sloughed’ cells. The significance of RPE phenotypes is addressable in longitudinal, high-resolution imaging in clinic populations. Data can motivate future molecular phenotyping studies. PMID:25813989

  18. Identification of Drusen Characteristics in Age-Related Macular Degeneration by Polarization-Sensitive Optical Coherence Tomography

    PubMed Central

    Schlanitz, Ferdinand G.; Sacu, Stefan; Baumann, Bernhard; Bolz, Matthias; Platzer, Maria; Pircher, Michael; Hitzenberger, Christoph K.; Schmidt-Erfurth, Ursula

    2015-01-01

    Purpose To describe qualitative characteristics of drusen in eyes with nonadvanced age-related macular degeneration (AMD) using polarization-sensitive optical coherence tomography (OCT). Design Cross-sectional study. Methods Twenty-five eyes of 25 patients with early to intermediate (nonadvanced) AMD were imaged with polarization-sensitive OCT using macular volume scans. All individual drusen in each B-scan were manually delineated by experts certified by a reading center and graded for 6 different morphologic characteristics based on a defined classification scheme, including the presence of internal depolarizing structures and associated depolarizing foci. With the use of a custom-made software, the central B-scan of each individual druse was selected and used to analyze its location, diameter, and characteristics and assess the prevalence of the different features and relations between them. Results Using the macular volume scans, 6224 individual drusen could be identified, including their position within the retina, their characteristics, and their association with any pigmentary alterations. The most common drusen type was a convex-shaped druse with homogeneous medium internal reflectivity and no depolarizing contents (55.3% of drusen). A total of 30.5% of the drusen exhibited internal depolarizing material; 0.3% presented overlying hyperreflective foci, and in 54.5% the foci were also depolarizing. Significant correlations were found between the diameter of the drusen and their distribution throughout the retina, shape, homogeneity of internal reflectivity, presence of internal depolarizing characteristics, and presence of overlying foci (P < .001 each). Significant relations were found between reflectivity, homogeneity, and polarization-sensitive internal characteristics (P < .001). Conclusions Polarization-sensitive OCT reveals characteristic morphologic features of different druse types highlighting the pathophysiological spectrum of early to intermediate AMD. PMID:25982973

  19. The frequency and infrared brightness of circumstellar discs at white dwarfs

    NASA Astrophysics Data System (ADS)

    Rocchetto, M.; Farihi, J.; Gänsicke, B. T.; Bergfors, C.

    2015-05-01

    White dwarfs whose atmospheres are polluted by terrestrial-like planetary debris have become a powerful and unique tool to study evolved planetary systems. This paper presents results for an unbiased Spitzer Infrared Array Camera search for circumstellar dust orbiting a homogeneous and well-defined sample of 134 single white dwarfs. The stars were selected without regard to atmospheric metal content but were chosen to have (1) hydrogen-rich atmospheres, (2) 17 000 < Teff < 25 000 K and correspondingly young post-main-sequence ages of 15-270 Myr, and (3) sufficient far-ultraviolet brightness for a corresponding Hubble Space Telescope COS snapshot. Five white dwarfs were found to host an infrared bright dust disc, three previously known, and two reported here for the first time, yielding a nominal 3.7^{+2.4}_{-1.0} per cent of white dwarfs in this post-main-sequence age range with detectable circumstellar dust. Remarkably, the complementary Hubble observations indicate that a fraction of 27 per cent show metals in their photosphere that can only be explained with ongoing accretion from circumstellar material, indicating that nearly 90 per cent of discs escape detection in the infrared, likely due to small emitting surface area. This paper also presents the distribution of disc fractional luminosity as a function of cooling age for all known dusty white dwarfs, suggesting possible disc evolution scenarios and indicating an undetected population of circumstellar discs.

  20. Environmentally benign manufacturing of compact disc stampers [Final Phase II report

    SciTech Connect

    1999-07-08

    Optical data storage is currently a $10B/yr. business. With the introduction of the high capacity Digital Versatile Disc (D/D) as well as the continued growth of CD-Audio and CD-ROM worldwide sales of optical data products as a whole are growing at rate of more than 10% per year. In North America, more than 2.5 billion optical discs will be sold in 1998. By 1999, the numbers of optical discs produced for the North American market will grow to almost three billion. The optical disc manufacturing industry is dominated by Asian and European companies (e.g. Sony of Japan and Philips of Netherlands). Prism Corporation has created a process that could significantly improve US competitiveness in the business of optical disc production. The objectives of the Phase II STTR project were to build and test an ion machining system (IMS) for stamper fabrication, prove overall manufacturing system feasibility by fabrication stampers and replicas, and evaluate alternative materials and alternative process parameters to optimize the process. During tie period of the Phase II project Prism Corporation was able to meet these objectives. In the course of doing so, adjustments had been made to better the project and in turn the final product. An ion machining system was designed and built that produced stampers ready for the molding process. Also, many control steps in the manufacturing process were studied to improve the current process and make it even more compatible with the industry standards, fitting seamlessly into current manufacturing lines.

  1. Galaxies that shine: radiation-hydrodynamical simulations of disc galaxies

    NASA Astrophysics Data System (ADS)

    Rosdahl, Joakim; Schaye, Joop; Teyssier, Romain; Agertz, Oscar

    2015-07-01

    Radiation feedback is typically implemented using subgrid recipes in hydrodynamical simulations of galaxies. Very little work has so far been performed using radiation-hydrodynamics (RHD), and there is no consensus on the importance of radiation feedback in galaxy evolution. We present RHD simulations of isolated galaxy discs of different masses with a resolution of 18 pc. Besides accounting for supernova feedback, our simulations are the first galaxy-scale simulations to include RHD treatments of photoionization heating and radiation pressure, from both direct optical/UV radiation and multiscattered, re-processed infrared (IR) radiation. Photoheating smooths and thickens the discs and suppresses star formation about as much as the inclusion of (`thermal dump') supernova feedback does. These effects decrease with galaxy mass and are mainly due to the prevention of the formation of dense clouds, as opposed to their destruction. Radiation pressure, whether from direct or IR radiation, has little effect, but for the IR radiation we show that its impact is limited by our inability to resolve the high optical depths for which multiscattering becomes important. While artificially boosting the IR optical depths does reduce the star formation, it does so by smoothing the gas rather than by generating stronger outflows. We conclude that although higher resolution simulations, and potentially also different supernova implementations, are needed for confirmation, our findings suggest that radiation feedback is more gentle and less effective than is often assumed in subgrid prescriptions.

  2. Cervical arthroplasty using ProDisc-C Case Report

    PubMed Central

    Nica, DA; Copaciu, R

    2013-01-01

    Cervical disc replacement is an emerging motion-preserving technology in the surgical treatment of the cervical degenerative disc disorders used as an alternative to the classic interbody fusion. We present a case report of a patient diagnosed with C6-7 right disc herniation who underwent anterior discectomy and received a total disc replacement using ProDisc C artificial disc prosthesis. PMID:23599830

  3. Interactive Visualization of a Thin Disc around a Schwarzschild Black Hole

    ERIC Educational Resources Information Center

    Muller, Thomas; Frauendiener, Jorg

    2012-01-01

    In a first course in general relativity, the Schwarzschild spacetime is the most discussed analytic solution to Einstein's field equations. Unfortunately, there is rarely enough time to study the optical consequences of the bending of light for some advanced examples. In this paper, we present how the visual appearance of a thin disc around a…

  4. D-Zero Cryostat Supplemental Rupture Disc

    SciTech Connect

    Mulholland, G.T.; /Fermilab

    1987-08-03

    The common relief and rupture disc vent line requires a double disc assembly with vented interspace for accurate disc burst pressures. The first disc must take pump and purge vacuum loading, but be set to operate at 110% of the MAWP, 18.3 psig (ASME code). The available solution is 18.3 psig with a burst tolerance of +/- psig. The interspace should be locally vented by a flow limiting vent valve to decouple the vent line backpressure from the vessel rupture disc. The second disc must take the worst case vent line backpressure, the steady state value found in D-Zero engineering note 3740.000-EN-63 with all three cryostats simultaneously venting at the fire condition into the 4-inch x 6-inch and 6-inch x 8-inch sections. This value is less than 2 psid. The maximum rupture value for the second disc must be less than the minimum rupture value for the first disc less 2 psid i.e. < 16.3.

  5. The Actual Level of Symptomatic Soft Disc Herniation in Patients with Cervical Disc Herniation

    PubMed Central

    Choi, Su Yong; Kim, Woo Kyung; Son, Seong; Jeong, Tae Seok

    2015-01-01

    Objective The aim of this study was to predict the relationship between the symptomatic disc herniation level and the osteophyte level or decreased disc height in patients with cervical disc herniation. Methods Between January 2011 and December 2012, 69 patients with an osteophyte of the cervical spine underwent surgery at a single center due to soft cervical disc herniation. Data including soft disc herniation level, osteophyte level in the posterior vertebral margin, Cobb's angle, and symptom duration were retrospectively assessed. The patients were divided into three groups according to the relationship between the degenerative change level and the level of reported symptoms. Results Among the 69 patients, 48 (69.6%) showed a match between osteophyte level and soft disc herniation level. Disc herniation occurred at the adjacent segment to degenerative osteophyte level in 12 patients (17.4%) and at both the adjacent and the osteophyte level in nine (13.0%). There was no significant difference in Cobb's angle or duration among the three groups. Osteophyte type was not significant. The mean disc height of the prominent degenerative change level group was lower than the adjacent segment level, but this was not significant. Conclusion Soft cervical disc herniation usually occurs at the level an osteophyte forms. However, it may also occur at segments adjacent to that of the osteophyte level. Therefore, in patients with cervical disc herniation, although a prominent osteophyte alone may appear on plain radiography, we must suspect the presence of soft disc herniation at other levels. PMID:26512266

  6. A debris disc under the influence of a wide planetary-mass companion: the system of HD 106906

    NASA Astrophysics Data System (ADS)

    Jílková, Lucie; Portegies Zwart, Simon

    2015-07-01

    The 13-Myr old star HD 106906 is orbited by a debris disc of at least 0.067 MMoon with inner and outer radii of 20 and 120 au, respectively, and by a planet at a distance of 650 au. We use this curious combination of a close low-mass disc and a wide planet to motivate our simulations of this system. We study the parameter space of the initial conditions to quantify the mass loss from the debris disc and its lifetime under the influence of the planet. We find that when the planet orbits closer to the star than about 50 au and with low inclination relative to the disc (less than about 10°), more disc material is perturbed outside than inside the region constrained by observations on time-scales shorter than 1 Myr. Considering the age of the system, such a short lifetime of the disc is incompatible with the time-scale for planet-planet scattering, which is one of the scenarios suggested to explain the wide separation of the planet. For some configurations, when the planet orbit is inclined with respect to the disc, the latter will start to wobble. We argue that this wobbling is caused by a mechanism similar to Kozai-Lidov oscillations. We also observe various resonant structures (such as rings and spiral arms) induced in the disc by the planet.

  7. Intrinsic disc emission and the soft X-ray excess in active galactic nuclei

    NASA Astrophysics Data System (ADS)

    Done, Chris; Davis, S. W.; Jin, C.; Blaes, O.; Ward, M.

    2012-03-01

    Narrow-line Seyfert 1 (NLS1) galaxies have low-mass black holes and mass accretion rates close to (or exceeding) Eddington, so a standard blackbody accretion disc should peak in the extreme ultraviolet. However, the lack of true absorption opacity in the disc means that the emission is better approximated by a colour temperature corrected blackbody, and this colour temperature correction is large enough (˜2.4) that the bare disc emission from a zero spin black hole can extend into the soft X-ray bandpass. Part of the soft X-ray excess seen in these objects must be intrinsic emission from the disc unless the vertical structure is very different to that predicted. None the less, this is not the whole story even for the extreme NLS1 as the shape of the soft excess is much broader than predicted by a bare disc spectrum, indicating some Compton upscattering by warm, optically thick material. We associate this with the disc itself, so it must ultimately be powered by mass accretion. We build an energetically self-consistent model assuming that the emission thermalizes to a (colour temperature corrected) blackbody only at large radii. At smaller radii the gravitational energy is split between powering optically thick Comptonized disc emission (forming the soft X-ray excess) and an optically thin corona above the disc (forming the tail to higher energies). We show examples of this model fit to the extreme NLS1 RE J1034+396, and to the much lower Eddington fraction broad-line Seyfert 1 PG 1048+231. We use these to guide our fits and interpretations of three template spectra made from co-adding multiple sources to track out a sequence of active galactic nucleus (AGN) spectra as a function of L/LEdd. Both the individual objects and template spectra show the surprising result that the Compton upscattered soft X-ray excess decreases in importance with increasing L/LEdd. The strongest soft excesses are associated with low mass accretion rate AGN rather than being tied to some change in disc structure around Eddington. We argue that this suggests a true break in accretion flow properties between stellar and supermassive black holes. The new model is publicly available within the XSPEC spectral fitting package.

  8. Stirring in Massive, Young Debris Discs from Spatially Resolved Herschel Images

    NASA Technical Reports Server (NTRS)

    Moor, A.; Kospal, A.; Abraham, P.; Apai, D.; Balog, Z.; Grady, Carol A.; Henning, Th.; Juhasz, A.; Kiss, Cs.; Krivov, A. V.; Pawellek, N.; Szabo, Gy. M.

    2014-01-01

    A significant fraction of main-sequence stars are encircled by dusty debris discs, where the short-lived dust particles are replenished through collisions between planetesimals. Most destructive collisions occur when the orbits of smaller bodies are dynamically stirred up, either by the gravitational effect of locally formed Pluto-sized planetesimals (self-stirring scenario), or via secular perturbation caused by an inner giant planet (planetary stirring). The relative importance of these scenarios in debris systems is unknown. Here we present new Herschel Space Observatory imagery of 11 discs selected from the most massive and extended known debris systems. All discs were found to be extended at far-infrared wavelengths, five of them being resolved for the first time. We evaluated the feasibility of the self-stirring scenario by comparing the measured disc sizes with the predictions of the model calculated for the ages of our targets. We concluded that the self-stirring explanation works for seven discs. However, in four cases, the predicted pace of outward propagation of the stirring front, assuming reasonable initial disc masses, was far too low to explain the radial extent of the cold dust. Therefore, for HD9672, HD16743, HD21997, and HD95086, another explanation is needed. We performed a similar analysis for Beta Pic and HR8799, reaching the same conclusion. We argue that planetary stirring is a promising possibility to explain the disk properties in these systems. In HR8799 and HD95086 we may already know the potential perturber, since their known outer giant planets could be responsible for the stirring process. Interestingly, the discs around HD9672, HD21997, and Beta Pic are also unique in harbouring detectable amount of molecular CO gas. Our study demonstrates that among the largest and most massive debris discs self-stirring may not be the only active scenario, and potentially planetary stirring is responsible for destructive collisions and debris dust production in a number of systems.

  9. Ages, durations and behavioural implications of Middle Stone Age industries in southern Africa: advances in optical dating of individual grains of quartz

    NASA Astrophysics Data System (ADS)

    Jacobs, Z.

    2009-04-01

    Recent developments in OSL dating have focussed on the measurement of individual sand-sized grains of quartz. Single-grain dating allows the identification of contaminant grains in a sample and their exclusion before final age determination, and the ability to directly check the stratigraphic integrity of archaeological sequences and address concerns about post-deposition sediment mixing. These benefits result in single-grain OSL ages being both accurate and precise. Even greater precision can be attained by adopting a systematic approach to the collection and analysis of OSL data. This involves one operator using the same OSL stimulation and detection instrument, laboratory radiation sources, calibration standards, and analytical procedures for all samples. By holding these experimental parameters constant, sources of error common to all samples are removed, enabling far greater resolution of the true age structure. This approach was recently used to determine the timing and duration of two bursts of Middle Stone Age technological and behavioural innovation - the Still Bay (SB) and Howieson's Poort (HP) - in southern Africa. These distinctive artefacts are associated with the first evidence for symbols and personal ornaments, and may have been the catalyst for the expansion of Homo sapiens populations in Africa 80,000-60,000 years ago and for the subsequent migration of modern humans out of Africa. Testing such hypotheses, and the putative role of climate change, has been hampered by poor age constraints for the HP and SB industries. Previous attempts to resolve the start and end dates of these industries had been largely obscured by the chronological' haze' arising from a variety of different materials being dated by different methods using different equipment, calibration standards, measurement procedures and techniques of data analysis. By clearing this haze and placing all ages on a common timescale, we were able to constrain the timing of the SB and HP, and the gap between them, to better than 3000 years at the 95% confidence interval. Both industries occur within the interval of population expansions in Africa inferred from genetic studies. A meta-analysis shows that our new ages are consistent with previous estimates but are more precise, revealing a lack of spatial patterning of the HP and SB across varied climatic and ecological zones. We find a temporal coincidence with major swings in climate, but not uniquely with these industries. Environmental factors may, therefore, have been responsible for episodic occupation of rock shelters, but were not the forcing mechanism behind the emergence of modern human behaviour.

  10. Evaluation of the accuracy of brain optical properties estimation at different ages using the frequency-domain multi-distance method

    NASA Astrophysics Data System (ADS)

    Dehaes, Mathieu; Grant, P. Ellen; Sliva, Danielle D.; Roche-Labarbe, Nadège; Pienaar, Rudolph; Boas, David A.; Franceschini, Maria Angela; Selb, Juliette

    2011-03-01

    NIRS is safe, non-invasive and offers the possibility to record local hemodynamic parameters at the bedside, avoiding the transportation of neonates and critically ill patients. In this work, we evaluate the accuracy of the frequency-domain multi-distance (FD-MD) method to retrieve brain optical properties from neonate to adult. Realistic measurements are simulated using a 3D Monte Carlo modeling of light propagation. Height different ages were investigated: a term newborn of 38 weeks gestational age, two infants of 6 and 12 months of age, a toddler of 2 year (yr.) old, two children of 5 and 10 years of age, a teenager of 14 yr. old, and an adult. Measurements are generated at multiple distances on the right parietal area of head models and fitted to a homogeneous FD-MD model to estimate the brain optical properties. In the newborn, infants, toddler and 5 yr. old child models, the error was dominated by the head curvature, while the superficial layer in the 10 yr. old child, teenager and adult heads. The influence of the CSF is also evaluated. In this case, absorption coefficients suffer from an additional error. In all cases, measurements at 5 mm provided worse estimation because of the diffusion approximation.

  11. Generation of highly inclined protoplanetary discs through single stellar flybys

    E-print Network

    Xiang-Gruess, Meng

    2015-01-01

    We study the three-dimensional evolution of a viscous protoplanetary disc which is perturbed by a passing star on a parabolic orbit. The aim is to test whether a single stellar flyby is capable to excite significant disc inclinations which would favour the formation of so-called misaligned planets. We use smoothed particle hydrodynamics to study inclination, disc mass and angular momentum changes of the disc for passing stars with different masses. We explore different orbital configurations for the perturber's orbit to find the parameter spaces which allow significant disc inclination generation. Prograde inclined parabolic orbits are most destructive leading to significant disc mass and angular momentum loss. In the remaining disc, the final disc inclination is only below $20^\\circ$. This is due to the removal of disc particles which have experienced the strongest perturbing effects. Retrograde inclined parabolic orbits are less destructive and can generate disc inclinations up to $60^\\circ$. The final disc...

  12. Kilonova light curves from the disc wind outflows of compact object mergers

    NASA Astrophysics Data System (ADS)

    Kasen, Daniel; Fernández, Rodrigo; Metzger, Brian D.

    2015-06-01

    We study the radioactively powered transients produced by accretion disc winds following a compact object merger. Based on the outflows found in two-dimensional hydrodynamical disc models, we use wavelength-dependent radiative transfer calculations to generate synthetic light curves and spectra. We show that resulting kilonova transients generally produce both optical and infrared emission, with the brightness and colour carrying information about the merger physics. In those regions of the wind subject to high neutrino irradiation, r-process nucleosynthesis may halt before producing high-opacity, complex ions (the lanthanides). The kilonova light curves thus typically has two distinct components: a brief (˜2 d) blue optical transient produced in the outer lanthanide-free ejecta, and a longer (˜10 d) infrared transient produced in the inner, lanthanide line-blanketed region. Mergers producing a longer lived neutron star, or a more rapidly spinning black hole, have stronger neutrino irradiation, generate more lanthanide-free ejecta and are optically brighter and bluer. At least some optical emission is produced in all disc wind models, which should enhance the detectability of electromagnetic counterparts to gravitational wave sources. However, the presence of even a small amount (10-4 M?) of overlying, neutron-rich dynamical ejecta will act as a `lanthanide-curtain', obscuring the optical wind emission from certain viewing angles. Because the disc outflows have moderate velocities (˜10 000 km s-1), numerous resolved line features are discernible in the spectra, distinguishing disc winds from fast-moving dynamical ejecta, and offering a potential diagnostic of the detailed composition of freshly produced r-process material.

  13. Optical Coherence Tomography Monitoring Strategies for A-VEGF—Treated Age-Related Macular Degeneration: An Evidence-Based Analysis

    PubMed Central

    Pron, G

    2014-01-01

    Background New anti-angiogenesis pharmacotherapies have dramatically altered treatment of age-related macular degeneration (AMD), the leading cause of blindness in older adults. Monthly intraocular injections however, are extremely burdensome to ophthalmologists, patients, and their families. Repeated injections also increase risks of complications or adverse events. Although the pharmacokinetics of anti–vascular endothelial growth factor (A-VEGF) drugs are fairly well known, an individuals’ AMD presentation and their pharmacodynamics or response to the drug has been shown to be extremely variable. Therefore treating everyone on the same fixed or standard regimen has potential for undertreating or overtreating patients, and drug costs are not trivial. Objectives To review monitoring strategies and to evaluate the role of optical coherence tomography (OCT) in guiding management of A-VEGF–treated neovascular AMD (n-AMD) patients. Data Sources Systematic reviews of biographic databases for studies published between 2008 and February 2013 involving A-VEGF–treated n-AMD patients monitored in longitudinal follow-up. Review Methods Studies were grouped according to varying treatments, monitoring schedules, and re-treatment protocols reported for n-AMD patients treated with A-VEGF. Several outcomes were evaluated across strategies including visual acuity (VA), retinal anatomy, re-treatment criteria and frequencies of clinical follow-up, OCT imaging investigations, and intravitreal injections. Results were summarized qualitatively, as heterogeneity in study objectives and methods precluded formal meta-analysis. Results A systematic review identified 18 randomized controlled trials (RCTs) and 20 observational studies involving A-VEGF treatment employing various monitoring and as-needed (PRN) re-treatment protocols. Several maintenance strategies were unsuccessful, resulting in lower VA gains and stabilization than monthly injections in A-VEGF–treated n-AMD. These included fixed quarterly treatment; fixed quarterly monitoring and PRN re-treatment; and monthly monitoring with either VA-guided re-treatment or quantitative-only VA/OCT- (central retinal thickness [CRT] > 100 ?m) guided re-treatment. PRN re-treatment strategies with A-VEGF on the basis of monthly follow-up and rigorous reviews of OCT qualitative and quantitative measures of disease activity did decrease injection burden while maintaining visual gains. Gains in VA obtained with PRN re-treatment in usual clinical practice, however, were not as high as gains in clinical trials. Conclusions To reduce treatment burden and provide a more individualized treatment strategy for n-AMD patients, OCT/VA-guided PRN treatment strategies have become the preferred and the dominant maintenance strategy. Success of these strategies, however, is dependent on close monitoring and adherence to tightly defined re-treatment criteria. PMID:26316918

  14. The properties of discs around planets and brown dwarfs as evidence for disc fragmentation

    E-print Network

    Stamatellos, Dimitris

    2015-01-01

    Direct imaging searches have revealed many very low-mass objects, including a small number of planetary mass objects, as wide-orbit companions to young stars. The formation mechanism of these objects remains uncertain. In this paper we present the predictions of the disc fragmentation model regarding the properties of the discs around such low-mass objects. We find that the discs around objects that have formed by fragmentation in discs hosted by Sun-like stars (referred to as 'parent' discs and 'parent' stars) are more massive than expected from the ${M}_{\\rm disc}-M_*$ relation (which is derived for stars with masses $M_*>0.2 {\\rm M}_{\\odot}$). Accordingly, the accretion rates onto these objects are also higher than expected from the $\\dot{M}_*-M_*$ relation. Moreover there is no significant correlation between the mass of the brown dwarf or planet with the mass of its disc nor with the accretion rate from the disc onto it. The discs around objects that form by disc fragmentation have larger than expected m...

  15. Effect of repetitive laser pulses on the electrical conductivity of intervertebral disc tissue

    SciTech Connect

    Omel'chenko, A I; Sobol', E N

    2009-03-31

    The thermomechanical effect of 1.56-{mu}m fibre laser pulses on intervertebral disc cartilage has been studied using ac conductivity measurements with coaxial electrodes integrated with an optical fibre for laser radiation delivery to the tissue. The observed time dependences of tissue conductivity can be interpreted in terms of hydraulic effects and thermomechanical changes in tissue structure. The laserinduced changes in the electrical parameters of the tissue are shown to correlate with the structural changes, which were visualised using shadowgraph imaging. Local ac conductivity measurements in the bulk of tissue can be used to develop a diagnostic/monitoring system for laser regeneration of intervertebral discs. (laser biology and medicine)

  16. Influence of the DiscFovea Angle on Limits of RNFL Variability and Glaucoma Discrimination

    E-print Network

    Levine, Alex J.

    ­fovea angle was measured on scanning laser ophthalmoscope fundus images from 170 eyes (110 normal and glaucoma was 2.08 (61.88). Predictors for DFA were female sex (P ¼ 0.004), smaller disc area (P ¼ 0 databases. These include patient age, quality of the SD-OCT image, axial length, and, most notably

  17. DISC1 genetics, biology and psychiatric illness

    PubMed Central

    THOMSON, Pippa A.; MALAVASI, Elise L.V.; GRÜNEWALD, Ellen; SOARES, Dinesh C.; BORKOWSKA, Malgorzata; MILLAR, J. Kirsty

    2012-01-01

    Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points towards DISC1 being one of the genes that influence risk of schizophrenia, bipolar disorder and depression, and functional studies of DISC1 consequently have the potential to reveal much about the pathways that lead to major mental illness. Here, we review the evidence that DISC1 influences disease risk through effects upon multiple critical pathways in the developing and adult brain. PMID:23550053

  18. Optical and thermoluminescence dating of Middle Stone Age and Kintampo bearing sediments at Birimi, a multi-component archaeological site in Ghana

    NASA Astrophysics Data System (ADS)

    Quickert, Nicole A.; Godfrey-Smith, Dorothy I.; Casey, Joanna L.

    2003-05-01

    We report the first luminescence ages for the archeological and geological sediments forming the substrate of the Birimi archaeological site in the Northern Region of Ghana. The site's significance rests on the fact that it contains a rich collection of artifact assemblages representative of three distinct cultures, and that, on the basis of artifact typology, the earliest assemblage is diagnostic of the Middle Stone Age (MSA) . In situ occurrences of MSA artifacts are found at over 1 m below today's surface. They are overlain by a ceramic-rich complex of a sedentary or semi-sendentary Later Stone Age culture known as the Kintampo. The western half of the site is dominated by the industrial remains of Iron Age smelting activity. Elemental, mineralogical, and sedimentological analysis of the cultural and sub-cultural sedimentary horizons at the site revealed at least three distinct lithostratigraphic units. The quartz sediments are derived from the sandstone of the Gambaga escarpment, mass wasted and accreted fluvially at a rate of 3.2 cm/ka, forming a wide terrace at Birimi. Silts and finer fractions derive from windblown dust, likely from White Volta River and granitic sources to the north. Soil forming processes and wide fluctuations in moisture have progressively reduced the sediments at depth to the resistant quartz and kaolinite, with rich iron oxide coatings, and created two ironstone horizons composed of goethite-cemented quartz nodules. Multiple aliquot green-light stimulated optical ages for 125-150 ?m quartz grains yielded ages of 23.6±2.9 and 40.8±11.8 ka for the MSA-bearing sediments, and 58.4±15.3 ka for the base of the terrace. Radiocarbon ages on charcoal from Kintampo-bearing units are 3.36-3.83 ka cal BP, and are supported by thermoluminescence (TL) ages on pottery sherds and burnt house daub fragments of this cultural complex. A 0.4 ka age on sediment from the site's surface confirms that the quartz zeroes well when exposed to natural light. Sediments bearing the Kintampo artifacts, however, yielded ages of 7.8-16.9 ka. These ages were obtained on sediments from large pits, some over 50 cm deep, and they deviate only slightly from the ages expected for naturally aggraded sediments at these depths. We conclude, therefore, that extensive digging of pits by the Kintampo dwellers was followed by rapid refilling, and that the bulk mobilization of the matrix did not permit the sedimentary quartz grains to experience any appreciable zeroing at that time.

  19. 21 CFR 866.1620 - Antimicrobial susceptibility test disc.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...antimicrobic-impregnated paper discs used to measure by a disc-agar diffusion technique or a disc-broth elution technique the in vitro...bacterial pathogens to antimicrobial agents. In the disc-agar diffusion technique, bacterial susceptibility is...

  20. 21 CFR 866.1620 - Antimicrobial susceptibility test disc.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...antimicrobic-impregnated paper discs used to measure by a disc-agar diffusion technique or a disc-broth elution technique the in vitro...bacterial pathogens to antimicrobial agents. In the disc-agar diffusion technique, bacterial susceptibility is...

  1. 21 CFR 866.1620 - Antimicrobial susceptibility test disc.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...antimicrobic-impregnated paper discs used to measure by a disc-agar diffusion technique or a disc-broth elution technique the in vitro...bacterial pathogens to antimicrobial agents. In the disc-agar diffusion technique, bacterial susceptibility is...

  2. 21 CFR 866.1620 - Antimicrobial susceptibility test disc.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...antimicrobic-impregnated paper discs used to measure by a disc-agar diffusion technique or a disc-broth elution technique the in vitro...bacterial pathogens to antimicrobial agents. In the disc-agar diffusion technique, bacterial susceptibility is...

  3. 21 CFR 872.3970 - Interarticular disc prosthesis (interpositional implant).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Interarticular disc prosthesis (interpositional... disc prosthesis (interpositional implant). (a) Identification. An interarticular disc prosthesis... Food and Drug Administration on or before March 30, 1999, for any interarticular disc...

  4. 21 CFR 872.3970 - Interarticular disc prosthesis (interpositional implant).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Interarticular disc prosthesis (interpositional... disc prosthesis (interpositional implant). (a) Identification. An interarticular disc prosthesis... Food and Drug Administration on or before March 30, 1999, for any interarticular disc...

  5. 21 CFR 872.3970 - Interarticular disc prosthesis (interpositional implant).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Interarticular disc prosthesis (interpositional... disc prosthesis (interpositional implant). (a) Identification. An interarticular disc prosthesis... Food and Drug Administration on or before March 30, 1999, for any interarticular disc...

  6. 21 CFR 872.3970 - Interarticular disc prosthesis (interpositional implant).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Interarticular disc prosthesis (interpositional... disc prosthesis (interpositional implant). (a) Identification. An interarticular disc prosthesis... Food and Drug Administration on or before March 30, 1999, for any interarticular disc...

  7. 21 CFR 872.3970 - Interarticular disc prosthesis (interpositional implant).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Interarticular disc prosthesis (interpositional... disc prosthesis (interpositional implant). (a) Identification. An interarticular disc prosthesis... Food and Drug Administration on or before March 30, 1999, for any interarticular disc...

  8. Study of a thermal lens in thin laser-ceramics discs

    SciTech Connect

    Snetkov, I L; Soloviev, A A; Khazanov, Efim A

    2009-04-30

    Thermal distortions of the radiation phase are studied theoretically in laser ceramics. Special attention is paid to the small-scale phase modulation inherent in ceramics, which is caused by the arbitrary orientation of its single-crystal grains. Expressions are derived which describe the average phase distortion and its dispersion in disc elements in approximations of a thin disc cooled through optical surfaces and of weak heat exchange. The numerical calculation has confirmed the high accuracy of these expressions. The proposed approximate solutions of the heat conduction and elasticity equations are of their own importance. In particular, the obtained solutions can be used to describe phase and polarisation distortions of radiation in an arbitrarily oriented single-crystal disc. (active media)

  9. Protoplanetary disc evolution affected by star-disc interactions in young stellar clusters

    E-print Network

    Rosotti, Giovanni P; Ovelar, Maria de Juan; Hubber, David A; Kruijssen, J M Diederik; Ercolano, Barbara; Walch, Stefanie

    2014-01-01

    Most stars form in a clustered environment. Therefore, it is important to assess how this environment influences the evolution of protoplanetary discs around young stars. In turn, this affects their ability to produce planets and ultimately life. We present here for the first time 3D SPH/N-body simulations that include both the hydrodynamical evolution of the discs around their natal stars, as well as the dynamics of the stars themselves. The discs are viscously evolving, accreting mass onto the central star and spreading. We find penetrating encounters to be very destructive for the discs as in previous studies, although the frequency of such encounters is low. We also find, however, that encounter influence the disc radii more strongly than other disc properties such as the disc mass. The disc sizes are set by the competition between viscous spreading and the disruptive effect of encounters. As discs spread, encounters become more and more important. In the regime of rapid spreading encounters simply trunca...

  10. Treatment of lumbar disc herniation by percutaneous laser disc decompression (PLDD) and modified PLDD

    NASA Astrophysics Data System (ADS)

    Chi, Xiao fei; Li, Hong zhi; Wu, Ru zhou; Sui, Yun xian

    2005-07-01

    Objective: To study the micro-invasive operative method and to compare the effect of treatment of PLDD and modified PLDD for Lumbar Disc Herniation. Method: Vaporized part of the nucleus pulposus in single or multiple point after acupuncture into lumbar disc, to reach the purpose of the decompression of the lumbar disc. Result: Among the 19 cases of the regular PLDD group, the excellent and good rate was 63.2%, and among the 40 cases of the modified PLDD group, the excellent and good rate was 82.5%. Conclusion: The modified PLDD has good effect on the treatment for lumbar disc herniation.

  11. Eclipse Mapping: Astrotomography of Accretion Discs

    E-print Network

    Baptista, Raymundo

    2015-01-01

    The Eclipse Mapping Method is an indirect imaging technique that transforms the shape of the eclipse light curve into a map of the surface brightness distribution of the occulted regions. Three decades of application of this technique to the investigation of the structure, the spectrum and the time evolution of accretion discs around white dwarfs in cataclysmic variables have enriched our understanding of these accretion devices with a wealth of details such as (but not limited to) moving heating/cooling waves during outbursts in dwarf novae, tidally-induced spiral shocks of emitting gas with sub-Keplerian velocities, elliptical precessing discs associated to superhumps, and measurements of the radial run of the disc viscosity through the mapping of the disc flickering sources. This chapter reviews the principles of the method, discusses its performance, limitations, useful error propagation procedures, as well as highlights a selection of applications aimed at showing the possible scientific problems that ha...

  12. Planet formation in self-gravitating discs 

    E-print Network

    Gibbons, Peter George

    2013-11-28

    The work performed here studies particle dynamics in local two-dimensional simulations of self-gravitating accretion discs with a simple cooling law. It is well known that the structure which arises in the gaseous component ...

  13. Evolution of solids in protoplanetary discs

    NASA Astrophysics Data System (ADS)

    Kornet, K.

    2006-10-01

    1d code designed to track the evolution of solids in protoplanetary discs from an early stage, when all solids are in the dust form, to the stage when most solids are in the form of a planetesimal swarm.

  14. Spontaneous Regression of a Large Lumbar Disc Extrusion

    PubMed Central

    Ryu, Sung-Joo

    2010-01-01

    Although the spontaneous disappearance or decrease in size of a herniated disc is well known, that of a large extruded disc has rarely been reported. This paper reports a case of a spontaneous regression of a large lumbar disc extrusion. The disc regressed spontaneously with clinical improvement and was documented on a follow up MRI study 6 months later. The literature is reviewed and the possible mechanisms of spontaneous disc regression are discussed. PMID:21082061

  15. Growth Factors and Anticatabolic Substances for Prevention and Management of Intervertebral Disc Degeneration

    PubMed Central

    Longo, Umile Giuseppe; Petrillo, Stefano; Franceschetti, Edoardo; Maffulli, Nicola; Denaro, Vincenzo

    2012-01-01

    Intervertebral disc (IVD) degeneration is frequent, appearing from the second decade of life and progressing with age. Conservative management often fails, and patients with IVD degeneration may need surgical intervention. Several treatment strategies have been proposed, although only surgical discectomy and arthrodesis have been proved to be predictably effective. Biological strategies aim to prevent and manage IVD degeneration, improving the function and anabolic and reparative capabilities of the nucleus pulposus and annulus fibrosus cells and inhibiting matrix degradation. At present, clinical applications are still in their infancy. Further studies are required to clarify the role of growth factors and anticatabolic substances for prevention and management of intervertebral disc degeneration. PMID:25098367

  16. A Metallurgical Investigation of Large Forged Discs of Low-carbon N-155 Alloy

    NASA Technical Reports Server (NTRS)

    Cross, Howard C; Freeman, J W

    1947-01-01

    Research was undertaken to ascertain the properties of better wrought heat resisting alloys in the form of large discs required for gas turbine rotors. The properties of large discs of low carbon N-155 alloy in both the as-forged and water-quenched and aged conditions were determined by means of stress-rupture and creep tests for time periods up to about 2000 hours at 1200, 1350, and 1500 F. Short-time tensile test, impact test, and time-total deformation characteristics are included. The principle results are given.

  17. Disc valve for sampling erosive process streams

    DOEpatents

    Mrochek, John E. (Oak Ridge, TN); Dinsmore, Stanley R. (Norris, TN); Chandler, Edward W. (Knoxville, TN)

    1986-01-01

    A four-port disc valve for sampling erosive, high temperature process streams. A rotatable disc defining opposed first and second sampling cavities rotates between fired faceplates defining flow passageways positioned to be alternatively in axial alignment with the first and second cavities. Silicon carbide inserts and liners composed of .alpha. silicon carbide are provided in the faceplates and in the sampling cavities to limit erosion while providing lubricity for a smooth and precise operation when used under harsh process conditions.

  18. Particle Acceleration in (by) Accretion Discs

    E-print Network

    J. I. Katz

    1992-05-04

    I present a model for acceleration of protons by the second-order Fermi process acting on randomly scrambled magnetic flux arches above an accretion disc. The accelerated protons collide with thermal protons in the disc, producing degraded energetic protons, charged and neutral pions, and neutrons. The pions produce gamma-rays by spontaneous decay of $\\pi^0$ and by bremsstrahlung and Compton processes following the decay of $\\pi^\\pm$ to $e^\\pm$.

  19. Investigation of cryogenic rupture disc design

    NASA Technical Reports Server (NTRS)

    Keough, J. B.; Oldland, A. H.

    1973-01-01

    Rupture disc designs of both the active (command actuated) and passive (pressure ruptured) types were evaluated for performance characteristics at cryogenic temperatures and for capability to operate in a variety of cryogens, including gaseous and liquid fluorine. The test results, coupled with information from literature and industry searches, were used to establish a statement of design criteria and recommended practices for application of rupture discs to cryogenic rocket propellant feed and vent systems.

  20. The JCMT Gould Belt Survey: low-mass protoplanetary discs from a SCUBA-2 census of NGC 1333

    NASA Astrophysics Data System (ADS)

    Dodds, P.; Greaves, J. S.; Scholz, A.; Hatchell, J.; Holland, W. S.; JCMT Gould Belt Survey Team

    2015-02-01

    NGC 1333 is a 1-2 Myr old cluster of stars in the Perseus molecular cloud. We used 850 ?m data from the Gould Belt Survey with SCUBA-2 on the James Clerk Maxwell Telescope to measure or place limits on disc masses for 82 Class II sources in this cluster. Eight disc candidates were detected; one is estimated to have mass of about 9 MJup in dust plus gas, while the others host only 2-4 MJup of circumstellar material. None of these discs exceeds the threshold for the `minimum mass solar nebula' (MMSN). This reinforces previous claims that only a small fraction of Class II sources at an age of 1-2 Myr have discs exceeding the MMSN threshold and thus can form a planetary system like our own. However, other regions with similarly low fractions of MMSN discs (IC 348, UpSco, ? Ori) are thought to be older than NGC 1333. Compared with coeval regions, the exceptionally low fraction of massive discs in NGC 1333 cannot easily be explained by the effects of UV radiation or stellar encounters. Our results indicate that additional environmental factors significantly affect disc evolution and the outcome of planet formation by core accretion.

  1. Rossby wave instability in 3D discs

    NASA Astrophysics Data System (ADS)

    Meheut, Heloise; Yu, Cong; Lai, Dong

    2012-05-01

    The Rossby wave instability (RWI) is a promising mechanism for producing large-scale vortices in protoplanetary discs. The instability operates around a density bump in the disc, and the resulting vortices may facilitate planetesimal formation and angular momentum transfer in the disc dead zone. Most previous works on the RWI deal with 2D (height-integrated) discs. However, vortices in 3D may have different dynamical behaviours from those in 2D. Recent numerical simulations of the RWI in 3D global discs by Meheut et al. have revealed intriguing vertical structure of the vortices, including appreciable vertical velocities. In this paper we present a linear analysis of the RWI, in 3D global models of isothermal discs. We calculate the growth rates of the Rossby modes (of various azimuthal wave numbers m= 2-6) trapped around the fiducial density bump and carry out 3D numerical simulations to compare with our linear results. We show that the 3D RWI growth rates are only slightly smaller than the 2D growth rates, and the velocity structures seen in the numerical simulations during the linear phase are in agreement with the velocity eigenfunctions obtained in our linear calculations. This numerical benchmark shows that numerical simulations can accurately describe the instability. The angular momentum transfer rate associated with Rossby vortices is also studied.

  2. Turbulent drag reduction through oscillating discs

    E-print Network

    Wise, Daniel J

    2014-01-01

    The changes of a turbulent channel flow subjected to oscillations of wall flush-mounted rigid discs are studied by means of direct numerical simulations. The Reynolds number is $R_\\tau$=$180$, based on the friction velocity of the stationary-wall case and the half channel height. The primary effect of the wall forcing is the sustained reduction of wall-shear stress, which reaches a maximum of 20%. A parametric study on the disc diameter, maximum tip velocity, and oscillation period is presented, with the aim to identify the optimal parameters which guarantee maximum drag reduction and maximum net energy saving, computed by taking into account the power spent to actuate the discs. This may be positive and reaches 6%. The Rosenblat viscous pump flow is used to predict the power spent for disc motion in the turbulent channel flow and to estimate localized and transient regions over the disc surface subjected to the turbulent regenerative braking effect, for which the wall turbulence exerts work on the discs. The...

  3. Synthesis of Organic Matter of Prebiotic Chemistry at the Protoplanetary Disc

    NASA Astrophysics Data System (ADS)

    Snytnikov, Valeriy; Stoynovskaya, Olga; Rudina, Nina

    We have carried out scanning electron microscopic examination of CM carbonaceous chondrites meteorites Migey, Murchison, Staroe Boriskino aged more than 4.56 billion years (about 50 million years from the beginning of the formation of the Solar system). Our study confirmed the conclusion of Rozanov, Hoover and other researchers about the presence of microfossils of bacterial origin in the matrix of all these meteorites. Since the time of the Solar system formation is 60 - 100 million years, the primary biocenosis emerged in the protoplanetary disc of the Solar system before meteorites or simultaneously with them. It means that prebiological processes and RNA world appeared even earlier in the circumsolar protoplanetary disc. Most likely, this appearance of prebiotic chemistry takes place nowday in massive and medium-massive discs of the observed young stellar objects (YSO) class 0 and I. The timescale of the transition from chemical to biological evolution took less than 50 million years for the Solar system. Further evolution of individual biocenosis in a protoplanetary disc associated with varying physico-chemical conditions during the formation of the Solar system bodies. Biocenosis on these bodies could remove or develop under the influence of many cosmic factors and geological processes in the case of Earth. To complete the primary biosphere formation in short evolution time - millions of years - requires highly efficient chemical syntheses. In industrial chemistry for the efficient synthesis of ammonia, hydrogen cyanide, methanol and other organic species, that are the precursors to obtain prebiotic compounds, catalytic reactors of high pressure are used. Thus (1) necessary amount of the proper catalyst in (2) high pressure areas of the disc can trigger these intense syntheses. The disc contains the solids with the size from nanoparticle to pebble. Iron and magnesium is catalytically active ingredient for such solids. The puzzle is a way to provide hydrogen pressure inside the disc from tens to hundred atmospheres. We simulated unsteady processes in massive circumstellar discs around YSO class O and I. In the computational experiments, we have shown that at a certain stage of its evolution the circumstellar discs of gas and solids produces local areas of high pressure. According to the classical heterogeneous catalysis, a wide range of organic and prebiotic compounds could have been synthesized in these areas. Can we capture these areas of high pressure synthesis in observation of circumstellar discs? Due to the small sizes of such areas they can be hardly ever resolved even with the modern telescopes such as ALMA. However, we can try to detect their signatures in the disc, since the gas of the disc keep the set of organic synthesis products. The idea is to define the signature of the process using laboratory experiments. Varying gas temperature and pressure in laboratory setup we can carry out the catalytic high pressure syntheses and specify the set of gaseous products. These sets of organic compounds observed in the discs may serve as indicators of the emergence of high-pressure areas of prebiotic chemistry. Thus, there is a special interest to the study of YSO class 0 and I by means of observational astronomy. For these objects, first data on the presence of individual organic compounds in massive hydrogen-helium component of the discs appear. The origin of the organic compounds that are associated with chemical reactions in the discs should be separated from the set of organic compounds of the initial molecular cloud.

  4. Rotational support of giant clumps in high-z disc galaxies

    NASA Astrophysics Data System (ADS)

    Ceverino, Daniel; Dekel, Avishai; Mandelker, Nir; Bournaud, Frederic; Burkert, Andreas; Genzel, Reinhard; Primack, Joel

    2012-03-01

    We address the internal support against total free-fall collapse of the giant clumps that form by violent gravitational instability in high-z disc galaxies. Guidance is provided by an analytic model, where the protoclumps are cut from a rotating disc and collapse to equilibrium while preserving angular momentum. This model predicts prograde clump rotation, which dominates the support if the clump has contracted to a surface density contrast ?10. This is confirmed in hydro adaptive mesh refinement zoom-in simulations of galaxies in a cosmological context. In most high-z clumps, the centrifugal force dominates the support, ?, where Vrot is the rotation velocity and the circular velocity Vcirc measures the potential well. The clump spin indeed tends to be in the sense of the global disc angular momentum, but substantial tilts are frequent, reflecting the highly warped nature of the high-z discs. Most clumps are in Jeans equilibrium, with the rest of the support provided by turbulence, partly driven by the gravitational instability itself. The general agreement between model and simulations indicates that angular momentum loss or gain in most clumps is limited to a factor of 2. Simulations of isolated gas-rich discs that resolve the clump substructure reveal that the cosmological simulations may overestimate ? by ˜30 per cent, but the dominance of rotational support at high z is not a resolution artefact. In turn, isolated gas-poor disc simulations produce at z= 0 smaller gaseous non-rotating transient clouds, indicating that the difference in rotational support is associated with the fraction of cold baryons in the disc. In our current cosmological simulations, the clump rotation velocity is typically more than twice the disc dispersion, Vrot˜ 100 km s-1, but when beam smearing of ?0.1 arcsec is imposed, the rotation signal is reduced to a small gradient of ?30 km s-1 kpc-1 across the clump. The velocity dispersion in the simulated clumps is comparable to the disc dispersion so it is expected to leave only a marginal signal for any beam smearing. Retrograde minor-merging galaxies could lead to massive clumps that do not show rotation even when marginally resolved. A testable prediction of the scenario as simulated is that the mean stellar age and the stellar fraction of the clumps are declining linearly with distance from the disc centre.

  5. Monitoring transformer oil insulation using optical absorption properties

    NASA Astrophysics Data System (ADS)

    Rose, Benjamin P.

    As the electrical power distribution system ages, new methods of determining the quality of electrical transformer units are needed. Due to the relatively high expense of loss of service and safety hazards, a relatively cheap sensor to track the age of the insulation would aide in the progress of an intelligent power grid. The degradation of solid insulating paper releases some of the age indicating organic compounds into the oil. At present, the only available method to determine the concentration of those compounds is to perform high performance liquid chromatography (HPLC) testing in a laboratory. This is an expensive and time consuming activity that also requires transformer to be taken offline. Currently there are no sensors that can directly (on-line) measure the chemical integrity of the material. This research was focused upon one of the well known organic compounds released by paper into the transformer oil - 2-furfuraldehyde (2FAL). Previous methods of 2FAL detection were explored and expounded upon. A device was constructed to utilize light emitting diodes to optically interrogate solid discs made out of chemically active material in multiple tests. A 10 kVA distribution transformer was fitted with a special device allowing a continuous oil circulation and the optical setup. The transformer was tested while being loaded under accelerated ageing conditions. A premature failure of the distribution transformer did not allow any correlation between concentration of 2FAL and the optical signals. Previously sampled oils for a current transformer (CT) were also tested for chemical analysis in the laboratory and optical signals from the newly developed optical device were obtained. A 95% linear correlation was found between the age of the CT oil and the output of the optical device. Although the technique was validated and does seem to have merit, more tests are needed before the optical device can be recommended for use in the field.

  6. Co-focused ultrasound and optical coherence elastography system for the study of age-related changes of biomechanical properties of crystalline lens in rabbit eyes

    NASA Astrophysics Data System (ADS)

    Wu, Chen; Han, Zhaolong; Wang, Shang; Li, Jiasong; Singh, Manmohan; Liu, Chih-hao; Aglyamov, Salavat; Emelianov, Stanislav; Manns, Fabrice; Larin, Kirill V.

    2015-03-01

    In this study, we utilize a confocal ultrasound and phase-sensitive optical coherence elastography (OCE) system to assess age-related changes in biomechanical properties of the crystalline lens in intact rabbit eyes in situ. Lowamplitude elastic deformations, induced on the surface of the lens by localized acoustic radiation force, were measured using phase-sensitive OCT. The results demonstrate that the displacements induced in young rabbit lenses are significantly larger than those in the mature lenses. Temporal analyses of the elastic waves are also demonstrated significant difference between young and old lenses, indicating that the stiffness of lens increases with the age. These results demonstrate possibility of OCE for completely noninvasive analysis and quantification of lens biomechanical properties, which could be used in many clinical and basic science applications such as surgeries and studies on lens physiology and function.

  7. Mechanical Vibrations Reduce the Intervertebral Disc Swelling and Muscle Atrophy from Bed Rest

    NASA Technical Reports Server (NTRS)

    Holguin, Nilsson; Muir, Jesse; Evans, Harlan J.; Qin, Yi-Xian; Rubin, Clinton; Wagshul, Mark; Judex, Stefan

    2007-01-01

    Loss of functional weight bearing, such as experienced during space flight or bed rest (BR), distorts intervertebral disc (IVD) and muscle morphology. IVDs are avascular structures consisting of cells that may derive their nutrition and waste removal from the load induced fluid flow into and out of the disc. A diurnal cycle is produced by forces related to weight bearing and muscular activity, and comprised of a supine and erect posture over a 24 hr period. A diurnal cycle will include a disc volume change of approx. 10-13%. However, in space there are little or no diurnal changes because of the microgravity, which removes the gravitational load and compressive forces to the back muscles. The BR model and the etiology of the disc swelling and muscle atrophy could provide insight into those subjects confined to bed for chronic disease/injury and aging. We hypothesize that extremely low-magnitude, high frequency mechanical vibrations will abate the disc degeneration and muscle loss associated with long-term BR.

  8. A computational spinal motion segment model incorporating a matrix composition-based model of the intervertebral disc.

    PubMed

    Barthelemy, V M P; van Rijsbergen, M M; Wilson, W; Huyghe, J M; van Rietbergen, B; Ito, K

    2016-02-01

    The extracellular matrix of the intervertebral disc is subjected to changes with age and degeneration, affecting the biomechanical behaviour of the spine. In this study, a finite element model of a generic spinal motion segment that links spinal biomechanics and intervertebral disc biochemical composition was developed. The local mechanical properties of the tissue were described by the local matrix composition, i.e. fixed charge density, amount of water and collagen and their organisation. The constitutive properties of the biochemical constituents were determined by fitting numerical responses to experimental measurements derived from literature. This general multi-scale model of the disc provides the possibility to evaluate the relation between local disc biochemical composition and spinal biomechanics. PMID:26469631

  9. Gold, carbon, and aluminum low-reflectivity compact discs as microassaying platforms.

    PubMed

    Brun, Eva M; Puchades, Rosa; Maquieira, Ángel

    2013-04-16

    Compact disc (CD) surface modification with different reflective materials offers new working perspectives as bioanalytical platforms. The potential of gold, carbon, and aluminum low-reflectivity compact discs as a substrate for microassaying is presented. CD polycarbonate bases were coated with these reflecting materials, maintaining optical properties. Probes immobilization onto reflective layers was studied by both passive adsorption and covalent linking. Different chemical modifications were made on substrates to provide functional groups capable of anchoring probes with primary amines covalently. Thus, self-assembled monolayers were performed by chemisorption of 11-mercaptoundecanoic acid on gold surfaces, and silanization with N-(trimethoxysilylpropyl)ethylenediamine triacetic acid on aluminum to provide a carboxylic acid functional group. Carbon oxidation with oxygen plasma afforded similar functionalization on the discs coated with this material. Performance of the studied materials as reflective layers was evaluated, and as proof of concept, a microimmunoassay for a neurotoxic compound was studied on the three surfaces. The results show the possibility of doing assays on this new supports with good analytical performances while maintaining discs' optical and mechanical properties to be read by a CD player. PMID:23489115

  10. DENVER DISC FILTER IN CO91107, SHOWING FIVE DOUBLESIDED DISCS AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DENVER DISC FILTER IN CO-91-107, SHOWING FIVE DOUBLE-SIDED DISCS AND DRIVE MOTOR. NOTE FOUR VERTICAL SLURRY FEED PIPES FROM OVERHEAD MANIFOLD AND SUCTION PIPE IN FOREGROUND. - Shenandoah-Dives Mill, 135 County Road 2, Silverton, San Juan County, CO

  11. Modeling and optimization of an elastic arthroplastic disc for a degenerated disc

    NASA Astrophysics Data System (ADS)

    Ghouchani, Azadeh; Ravari, Mohammad; Mahmoudi, Farid

    2011-10-01

    A three-dimensional finite element model (FEM) of the L3-L4 motion segment using ABAQUS v 6.9 has been developed. The model took into account the material nonlinearities and is imposed different loading conditions. In this study, we validated the model by comparison of its predictions with several sets of experimental data. Disc deformation under compression and segmental rotational motions under moment loads for the normal disc model agreed well with the corresponding in vivo studies. By linking ABAQUS with MATLAB 2010.a, we determined the optimal Young s modulus as well as the Poisson's ratio for the artificial disc under different physiologic loading conditions. The results of the present study confirmed that a well-designed elastic arthroplastic disc preferably has an annulus modulus of 19.1 MPa and 1.24 MPa for nucleus section and Poisson ratio of 0.41 and 0.47 respectively. Elastic artificial disc with such properties can then achieve the goal of restoring the disc height and mechanical function of intact disc under different loading conditions and so can reduce low back pain which is mostly caused due to disc degeneration.

  12. Defocus Incorporated Soft Contact (DISC) lens slows myopia progression in Hong Kong Chinese schoolchildren: a 2-year randomised clinical trial

    PubMed Central

    Lam, Carly Siu Yin; Tang, Wing Chun; Tse, Dennis Yan-Yin; Tang, Ying Yung; To, Chi Ho

    2014-01-01

    Aims To determine if ‘Defocus Incorporated Soft Contact’ (DISC) lens wear slows childhood myopia progression. Methods A 2-year double-blind randomised controlled trial was carried out in 221 children aged 8–13?years, with myopia between ?1.00 and ?5.00 Dioptres (D) and astigmatism ?1.00?D. Subjects were randomly assigned to the DISC (n=111) or single vision (SV; n=110) contact lens group. DISC lenses incorporated concentric rings, which provided an addition of +2.50?D, alternating with the normal distance correction. Refractive error (cycloplegic autorefraction) and axial length were measured at 6-month intervals. Differences between groups were analysed using unpaired t test. Results In total, 128 children completed the study, n=65 in the DISC group and n=63 in the SV group. Myopia progressed 25% more slowly for children in the DISC group compared with those in the control group (0.30?D/year; 95% CI ?0.71 to ?0.47 vs 0.4?D/year; 95% CI ?0.93 to ?0.65, p=0.031). Likewise, there was less axial elongation for children in the DISC versus SV groups (0.13?mm/year; 95% CI 0.20 to 0.31 vs 0.18?mm/year; 95% CI 0.30 to 0.43, p=0.009). Treatment effect correlated positively with DISC lens wearing time (r=0.342; p=0.005). Indeed, myopia in children who wore the DISC lenses for five or more hours/day progressed 46% (mean difference=?0.382?D, p=0.001; 95% CI ?0.59 to ?0.17) less than those in the SV group. Conclusions The daily wearing of DISC lens significantly slowed myopia progression and axial elongation in Hong Kong schoolchildren. The findings demonstrated that simultaneous clear vision with constant myopic defocus can retard myopia progression. PMID:24169657

  13. Only marginal alignment of disc galaxies

    NASA Astrophysics Data System (ADS)

    Andrae, René; Jahnke, Knud

    2011-12-01

    Testing theories of angular-momentum acquisition of rotationally supported disc galaxies is the key to understanding the formation of this type of galaxies. The tidal-torque theory aims to explain this acquisition process in a cosmological framework and predicts positive autocorrelations of angular-momentum orientation and spiral-arm handedness, i.e. alignment of disc galaxies, on short distance scales of 1 Mpc h-1. This disc alignment can also cause systematic effects in weak-lensing measurements. Previous observations claimed discovering these correlations but are overly optimistic in the reported level of statistical significance of the detections. Errors in redshift, ellipticity and morphological classifications were not taken into account, although they have a significant impact. We explain how to rigorously propagate all the important errors through the estimation process. Analysing disc galaxies in the Sloan Digital Sky Survey (SDSS) data base, we find that positive autocorrelations of spiral-arm handedness and angular-momentum orientations on distance scales of 1 Mpc h-1 are plausible but not statistically significant. Current data appear not good enough to constrain parameters of theory. This result agrees with a simple hypothesis test in the Local Group, where we also find no evidence for disc alignment. Moreover, we demonstrate that ellipticity estimates based on second moments are strongly biased by galactic bulges even for Scd galaxies, thereby corrupting correlation estimates and overestimating the impact of disc alignment on weak-lensing studies. Finally, we discuss the potential of future sky surveys. We argue that photometric redshifts have too large errors, i.e. PanSTARRS and LSST cannot be used. Conversely, the EUCLID project will not cover the relevant redshift regime. We also discuss the potentials and problems of front-edge classifications of galaxy discs in order to improve the autocorrelation estimates of angular-momentum orientation.

  14. Plasma-mediated disc decompression for contained cervical disc herniation: results through 5 years.

    PubMed

    Cesaroni, Alessandro; Nardi, Pier Vittorio

    2011-01-01

    Conventional treatment for cervical disc herniations often defaults to open cervical discectomy, potentially supplemented by intervertebral fusion. Newer treatment strategies focus on percutaneous, minimally invasive procedures which are capable of resolving herniation pathology while offering decreased morbidity and convalescence time when compared to fusion. In cases where patients complain of radicular and neck pain symptoms related to a contained herniated disc, plasma disc decompression may be used as a minimally invasive treatment option on the cervical intervertebral discs.Three hundred and forty-nine patients who presented with a contained herniated cervical disc or focal protrusion causing pain associated with cervical nerve root compression were treated between January 2003 and May 2007. This case series study was conducted to evaluate clinical results through 1 year postoperatively. PMID:21107946

  15. Assessing Age-Related Changes in the Biomechanical Properties of Rabbit Lens Using a Coaligned Ultrasound and Optical Coherence Elastography System

    PubMed Central

    Wu, Chen; Han, Zhaolong; Wang, Shang; Li, Jiasong; Singh, Manmohan; Liu, Chih-hao; Aglyamov, Salavat; Emelianov, Stanislav; Manns, Fabrice; Larin, Kirill V.

    2015-01-01

    Purpose. To evaluate the capability of a novel, coaligned focused ultrasound and phase-sensitive optical coherence elastography (US-OCE) system to assess age-related changes in biomechanical properties of the crystalline lens in situ. Methods. Low-amplitude elastic deformations in young and mature rabbit lenses were measured by an US-OCE system consisting of a spectral-domain optical coherence tomography (OCT) system coaligned with a focused ultrasound system used to produce a transient force on the lens surface. Uniaxial compressional tests were used to validate the OCE data. Results. The OCE measurements showed that the maximum displacements of the young rabbit lenses were significantly larger than those of the mature lenses, indicating a gradual increase of the lens stiffness with age. Temporal analyses of the displacements also demonstrate a similar trend of elastic properties in these lenses. The stress-strain measurements using uniaxial mechanical tests confirmed the results obtained by the US-OCE system. Conclusions. The results demonstrate that the US-OCE system can be used for noninvasive analysis and quantification of lens biomechanical properties in situ and possibly in vivo. PMID:25613945

  16. Efficacy of Percutaneous Epidural Neuroplasty Does Not Correlate with Dural Sac Cross-Sectional Area in Single Level Disc Disease

    PubMed Central

    Ji, Gyu Yeul; Oh, Chang Hyun; Moon, Bongju; Choi, Seung Hyun; Yoon, Young Sul; Kim, Keung Nyun

    2015-01-01

    Purpose Percutaneous epidural neuroplasty (PEN) is a minimally invasive treatment. The efficacy of PEN has been relatively well investigated; however, the relationship between the clinical effectiveness of PEN and the severity of spinal canal stenosis by disc material has not yet been established. The purpose of this study was to compare clinical outcomes of PEN according to the dural sac cross-sectional area in single level disc disease. Materials and Methods This study included 363 patients with back pain from single level disc disease with and without radiculopathy. Patients were categorized into groups according to spinal canal compromise by disc material: Category 1, less or more than 50%; and Category 2, three subgroups with lesser than a third, between a third and two thirds, and more than two thirds. Clinical outcomes were assessed according to the Visual Analog Scale (VAS) score for back pain and leg pain and Odom's criteria at 1, 3, 6, 12, and 24 months after treatment. Results The demographic data showed no difference between groups according to spinal canal compromise by disc material except age (older age correlated with more spinal canal compromise). The dural sac cross-sectional area did not correlate with the VAS scores for back and leg pain after PEN in single level disc disease in Groups 1 and 2. Odom's criteria after PEN were also not different according to dural sac cross-sectional area by disc material. Conclusion PEN is an effective procedure in treating single level lumbar disc herniation without affecting dural sac cross-sectional area. PMID:25837174

  17. Biogeographic Ancestry in the African Descent and Glaucoma Evaluation Study (ADAGES): Association With Corneal and Optic Nerve Structure

    PubMed Central

    Girkin, Christopher A.; Nievergelt, Caroline M.; Kuo, Jane Z.; Maihofer, Adam X.; Huisingh, Carrie; Liebmann, Jeffrey M.; Ayyagari, Radha; Weinreb, Robert N.; Ritch, Robert; Zangwill, Linda M.

    2015-01-01

    Purpose. We determined if quantitative measurements of biogeographic ancestry (BGA) correlate with variations in optic disc area, corneal thickness (CCT), and retinal nerve fiber layer (RNFL) thickness. Methods. Data were obtained from 656 participants in the African Descent and Glaucoma Evaluation Study (ADAGES) cohort who consented to BGA testing. Data for CCT, optic disc area, and RNFL thickness were obtained from subjects in the ADAGES study who also had participated in the current substudy. A total of 31 ancestry informative markers (AIMs) with large allele frequencies differences between populations was used to calculate admixture proportion (implemented in STRUCTURE). Correlations with BGA adjusted for diagnosis, age, and sex for CCT and optic disc area using the whole group and RNFL thickness adjusted for age and sex for the normal study participants were determined. Results. The mean percentage of African admixture was 79.6% in the self-described African Descent (AD) group and 3.5% in the European Descent (ED) group. Percent African ancestry was significantly correlated with CCT (? = ?0.27, P < 0.0001) and disc area (? = 0.15, P < 0.0001), but only marginally associated with RNFL thickness (? = 0.20, P = 0.092) in adjusted models. Conclusions. The BGA correlates with variation in ocular features that significantly differ across racial groups and that have been associated with the development of glaucoma. While BGA can provide an objective measurement of the biologic component of self-described race for ocular research, for most nongenetic epidemiologic studies, self-described race may adequately describe the associations with these ocular characteristics. (ClinicalTrials.gov number, NCT00221923.) PMID:25744975

  18. Formation of planetary debris discs around white dwarfs - II. Shrinking extremely eccentric collisionless rings

    NASA Astrophysics Data System (ADS)

    Veras, Dimitri; Leinhardt, Zoë M.; Eggl, Siegfried; Gänsicke, Boris T.

    2015-08-01

    The formation channel of the tens of compact debris discs which orbit white dwarfs (WDs) at a distance of 1 R? remains unknown. Asteroids that survive the giant branch stellar phases beyond a few au are assumed to be dynamically thrust towards the WD and tidally disrupted within its Roche radius, generating extremely eccentric (e > 0.98) rings. Here, we establish that WD radiation compresses and circularizes the orbits of supermicron to cm-sized ring constituents to entirely within the WD's Roche radius. We derive a closed algebraic formula which well-approximates the shrinking time as a function of WD cooling age, the physical properties of the star and the physical and orbital properties of the ring particles. The shrinking time-scale increases with both particle size and cooling age, yielding age-dependent WD debris disc size distributions.

  19. Debris Discs: Modeling/theory review

    NASA Astrophysics Data System (ADS)

    Thébault, P.

    2012-03-01

    An impressive amount of photometric, spectroscopic and imaging observations of circumstellar debris discs has been accumulated over the past 3 decades, revealing that they come in all shapes and flavours, from young post-planet-formation systems like Beta-Pic to much older ones like Vega. What we see in these systems are small grains, which are probably only the tip of the iceberg of a vast population of larger (undetectable) collisionally-eroding bodies, leftover from the planet-formation process. Understanding the spatial structure, physical properties, origin and evolution of this dust is of crucial importance, as it is our only window into what is going on in these systems. Dust can be used as a tracer of the distribution of their collisional progenitors and of possible hidden massive pertubers, but can also allow to derive valuable information about the disc's total mass, size distribution or chemical composition. I will review the state of the art in numerical models of debris disc, and present some important issues that are explored by current modelling efforts: planet-disc interactions, link between cold (i.e. Herschel-observed) and hot discs, effect of binarity, transient versus continuous processes, etc. I will finally present some possible perspectives for the development of future models.

  20. Metallicity, planet formation, and disc lifetimes

    E-print Network

    Ercolano, Barbara

    2009-01-01

    The formation of planets within a disc must operate within the time frame of disc dispersal, it is thus crucial to establish what is the dominant process that disperses the gaseous component of discs around young stars. Planet formation itself as well as photoevaporation by energetic radiation from the central young stellar object have been proposed as plausible dispersal mechanisms. [abridged]. In this paper we use the different metallicity dependance of X-ray photoevaporation and planet formation to discriminate between these two processes. We study the effects of metallicity, Z, on the dispersal timescale, t_phot, in the context of a photoevaporation model, by means of detailed thermal calculations of a disc in hydrostatic equilibrium irradiated by EUV and X-ray radiation from the central source. Our models show t_phot \\propto Z^0.52 for a pure photoevaporation model. By means of analytical estimates we derive instead a much stronger negative power dependance on metallicity of the disc lifetime for a dispe...

  1. Genetic aspects of intervertebral disc degeneration.

    PubMed

    Hanaei, Sara; Abdollahzade, Sina; Khoshnevisan, Alireza; Kepler, Christopher K; Rezaei, Nima

    2015-10-01

    Intervertebral disc degeneration (IVDD) is one of the common causes of low back pain. Similar to many other multifactorial diseases, it is affected by environmental and genetic factors. Although not completely understood, genetic factors include a wide spectrum of variations, such as single nucleotide polymorphisms, which could play a significant role in the etiology of this disease. Besides, the interactions with environmental factors could make the role of genetic factors more complicated. Genetic variations in disc components could participate in developing degenerative disc disease through altering the normal homeostasis of discs. Gene polymorphisms in disc proteins (collagens I, II, III, IX, and XI), proteoglycans (aggrecan), cytokines (interleukins I, VI, and X), enzymes (matrix metalloproteinases II, III, and IX), and vitamin D receptor seem to play considerable roles in the pathology of this disease. There are also many other investigated genes that could somehow take part in the process. However, it seems that more studies are needed to clarify the exact role of genetics in IVDD. PMID:25996483

  2. Evidence from stellar rotation of enhanced disc dispersal: (I) The case of the triple visual system BD-21 1074 in the $\\beta$ Pictoris association

    E-print Network

    Messina, S; Biazzo, K; Melo, C H F; Frasca, A

    2014-01-01

    The early stage of stellar evolution is characterized by a star-disc locking mechanism. The disc-locking prevents the star to spin its rotation up, and its timescale depends on the disc lifetime. Some mechanisms can significantly shorten this lifetime, allowing a few stars to start spinning up much earlier than other stars. In the present study, we aim to investigate how the properties of the circumstellar environment can shorten the disc lifetime. We have identified a few multiple stellar systems, composed of stars with similar masses, which belong to associations with a known age. Since all parameters that are responsible for the rotational evolution, with the exception of environment properties and initial stellar rotation, are similar for all components, we expect that significant differences among the rotation periods can only arise from differences in the disc lifetimes. A photometric timeseries allowed us to measure the rotation periods of each component, while high-resolution spectra provided us with ...

  3. Use of the NASA GEOS-5 SEAC4RS Meteorological and Aerosol Reanalysis for assessing simulated aerosol optical properties as a function of smoke age

    NASA Astrophysics Data System (ADS)

    Randles, C. A.; da Silva, A. M., Jr.; Colarco, P. R.; Darmenov, A.; Buchard, V.; Govindaraju, R.; Chen, G.; Hair, J. W.; Russell, P. B.; Shinozuka, Y.; Wagner, N.; Lack, D.

    2014-12-01

    The NASA Goddard Earth Observing System version 5 (GEOS-5) Earth system model, which includes an online aerosol module, provided chemical and weather forecasts during the SEAC4RS field campaign. For post-mission analysis, we have produced a high resolution (25 km) meteorological and aerosol reanalysis for the entire campaign period. In addition to the full meteorological observing system used for routine NWP, we assimilate 550 nm aerosol optical depth (AOD) derived from MODIS (both Aqua and Terra satellites), ground-based AERONET sun photometers, and the MISR instrument (over bright surfaces only). Daily biomass burning emissions of CO, CO2, SO2, and aerosols are derived from MODIS fire radiative power retrievals. We have also introduced novel smoke "age" tracers, which provide, for a given time, a snapshot histogram of the age of simulated smoke aerosol. Because GEOS-5 assimilates remotely sensed AOD data, it generally reproduces observed (column) AOD compared to, for example, the airborne 4-STAR instrument. Constraining AOD, however, does not imply a good representation of either the vertical profile or the aerosol microphysical properties (e.g., composition, absorption). We do find a reasonable vertical structure for aerosols is attained in the model, provided actual smoke injection heights are not much above the planetary boundary layer, as verified with observations from DIAL/HRSL aboard the DC8. The translation of the simulated aerosol microphysical properties to total column AOD, needed in the aerosol assimilation step, is based on prescribed mass extinction efficiencies that depend on wavelength, composition, and relative humidity. Here we also evaluate the performance of the simulated aerosol speciation by examining in situ retrievals of aerosol absorption/single scattering albedo and scattering growth factor (f(RH)) from the LARGE and AOP suite of instruments. Putting these comparisons in the context of smoke age as diagnosed by the model helps us to revise assumed aerosol optical properties for an improved representation of aerosol radiative forcing.

  4. Higher preoperative Oswestry Disability Index is associated with better surgical outcome in upper lumbar disc herniations.

    PubMed

    Saberi, Hooshang; Isfahani, Arash Vatankhahan

    2008-01-01

    To evaluate the surgical outcome in terms of functional and subjective recovery, patients who needed discectomies at L1-L2, L2-L3 and L3-L4 levels were compared with an age and sex-matched group of patients who required L4-L5 and L5-S1 discectomies. We prospectively enrolled 50 consecutive patients, referred to our center, who had L1-L2, L2-L3 and L3-L4 herniations and required surgical intervention. Likewise, a comparative group of 50 consecutive patients with herniations at L4-L5 and L5-S1 were selected. All 100 patients were treated and followed for a 1 year period. Physical examination findings as well as Oswestry Disability Questionnaire before surgery were recorded. After 1 year, patients were requested to fill the same questionnaire. Significant decline in the Oswestry Disability Index (ODI) scores was considered to be a measure of functional improvement and recovery. The mean age of patients with upper lumbar disc herniation (L1-L2, L2-L3, L3-L4) was 45.7 years and patients with lower lumbar disc herniation (L4-L5, L5-S1) had a mean age of 41.2 years. There was no statistically significant difference in age between the two groups. The preoperative Oswestry Disability (ODI) Index score had a statistically significant impact on ODI score improvement after surgery in both lower and upper lumbar disc groups. All 100 patients with either lower or upper lumbar disc herniation had statistically significant ODI change after surgical intervention (P < 0.0001 for both groups). However, patients with upper disc herniations and moderate preoperative disability (ODI of 21-40%) did not show significant improvement, while patients with ODI greater than 40% had significant reduction (P = 0.018). Surprisingly, as many as 25% of the former had even an increase in ODI scores after surgery. Gender was also a conspicuous factor in determining the surgical outcome of patients with upper lumbar disc herniation, and male patients had more reduction in ODI score than female patients (P = 0.007). Since the functional recovery in patients with herniated lumbar disc, especially upper lumbar herniation, is influenced by preoperative ODI scores, the use of ODI or any other standard pain assessment tool is a sensible consideration as an inherent investigative method to preclude unfavorable surgical outcome. PMID:17972115

  5. Higher preoperative Oswestry Disability Index is associated with better surgical outcome in upper lumbar disc herniations

    PubMed Central

    Isfahani, Arash Vatankhahan

    2007-01-01

    To evaluate the surgical outcome in terms of functional and subjective recovery, patients who needed discectomies at L1–L2, L2–L3 and L3–L4 levels were compared with an age and sex-matched group of patients who required L4–L5 and L5–S1 discectomies. We prospectively enrolled 50 consecutive patients, referred to our center, who had L1–L2, L2–L3 and L3–L4 herniations and required surgical intervention. Likewise, a comparative group of 50 consecutive patients with herniations at L4–L5 and L5–S1 were selected. All 100 patients were treated and followed for a 1 year period. Physical examination findings as well as Oswestry Disability Questionnaire before surgery were recorded. After 1 year, patients were requested to fill the same questionnaire. Significant decline in the Oswestry Disability Index (ODI) scores was considered to be a measure of functional improvement and recovery. The mean age of patients with upper lumbar disc herniation (L1–L2, L2–L3, L3–L4) was 45.7 years and patients with lower lumbar disc herniation (L4–L5, L5–S1) had a mean age of 41.2 years. There was no statistically significant difference in age between the two groups. The preoperative Oswestry Disability (ODI) Index score had a statistically significant impact on ODI score improvement after surgery in both lower and upper lumbar disc groups. All 100 patients with either lower or upper lumbar disc herniation had statistically significant ODI change after surgical intervention (P < 0.0001 for both groups). However, patients with upper disc herniations and moderate preoperative disability (ODI of 21–40%) did not show significant improvement, while patients with ODI greater than 40% had significant reduction (P = 0.018). Surprisingly, as many as 25% of the former had even an increase in ODI scores after surgery. Gender was also a conspicuous factor in determining the surgical outcome of patients with upper lumbar disc herniation, and male patients had more reduction in ODI score than female patients (P = 0.007). Since the functional recovery in patients with herniated lumbar disc, especially upper lumbar herniation, is influenced by preoperative ODI scores, the use of ODI or any other standard pain assessment tool is a sensible consideration as an inherent investigative method to preclude unfavorable surgical outcome. PMID:17972115

  6. Generation of highly inclined protoplanetary discs through single stellar flybys

    NASA Astrophysics Data System (ADS)

    Xiang-Gruess, M.

    2016-01-01

    We study the three-dimensional evolution of a viscous protoplanetary disc which is perturbed by a passing star on a parabolic orbit. The aim is to test whether a single stellar flyby is capable to excite significant disc inclinations which would favour the formation of so-called misaligned planets. We use smoothed particle hydrodynamics to study inclination, disc mass and angular momentum changes of the disc for passing stars with different masses. We explore different orbital configurations for the perturber's orbit to find the parameter spaces which allow significant disc inclination generation. Prograde inclined parabolic orbits are most destructive leading to significant disc mass and angular momentum loss. In the remaining disc, the final disc inclination is only below 20°. This is due to the removal of disc particles which have experienced the strongest perturbing effects. Retrograde inclined parabolic orbits are less destructive and can generate disc inclinations up to 60°. The final disc orientation is determined by the precession of the disc angular momentum vector about the perturber's orbital angular momentum vector and by disc orbital inclination changes. We propose a sequence of stellar flybys for the generation of misalignment angles above 60°. The results taken together show that stellar flybys are promising and realistic for the explanation of misaligned Hot Jupiters with misalignment angles up to 60°.

  7. The spatially-resolved star formation history of the M31 outer disc

    NASA Astrophysics Data System (ADS)

    Bernard, Edouard J.; Ferguson, Annette M. N.; Chapman, Scott C.; Ibata, Rodrigo A.; Irwin, Mike J.; Lewis, Geraint F.; McConnachie, Alan W.

    2015-10-01

    We present deep Hubble Space Telescope Advanced Camera for Surveys observations of the stellar populations in two fields lying at 20 and 23 kpc from the centre of M31 along the south-west semimajor axis. These data enable the construction of colour-magnitude diagrams reaching the oldest main-sequence turn-offs (˜13 Gyr) which, when combined with another field at 25 kpc from our previous work, we use to derive the first precision constraints on the spatially-resolved star formation history of the M31 disc. The star formation rates exhibit temporal as well as field-to-field variations, but are generally always within a factor of 2 of their time average. There is no evidence of inside-out growth over the radial range probed. We find a median age of ˜7.5 Gyr, indicating that roughly half of the stellar mass in the M31 outer disc was formed before z ˜ 1. We also find that the age-metallicity relations (AMRs) are smoothly increasing from [Fe/H] ? -0.4 to solar metallicity between 10 and 3 Gyr ago, contrary to the flat AMR of the Milky Way disc at a similar number of scalelengths. Our findings provide insight on the roles of stellar feedback and radial migration in the formation and evolution of large disc galaxies.

  8. MSC response to pH levels found in degenerating intervertebral discs

    SciTech Connect

    Wuertz, Karin Godburn, Karolyn; Iatridis, James C.

    2009-02-20

    Painful degenerative disc disease is a major health problem and for successful tissue regeneration, MSCs must endure and thrive in a harsh disc microenvironment that includes matrix acidity as a critical factor. MSCs were isolated from bone marrow of Sprague-Dawley rats from two different age groups (<1 month, n = 6 and 4-5 months, n = 6) and cultured under four different pH conditions representative of the healthy, mildly or severely degenerated intervertebral disc (pH 7.4, 7.1, 6.8, and 6.5) for 5 days. Acidity caused an inhibition of aggrecan, collagen-1, and TIMP-3 expression, as well as a decrease in proliferation and viability and was associated with a change in cell morphology. Ageing had generally minor effects but young MSCs maintained greater mRNA expression levels. As acidic pH levels are typical of increasingly degenerated discs, our findings demonstrate the importance of early interventions and predifferentiation when planning to use MSCs for reparative treatments.

  9. [Pain related impairment and the ability to function in herniated disc patients during rehabilitation].

    PubMed

    Kitze, K; Rust, V; Angermeyer, M C

    2007-12-01

    Herniated discs usually occur in middle aged persons. For some the pain is so serious that an operation is necessary. Yet despite modern micro-surgical methods for operations, approximately one-third of the patients continue to report ongoing limitations. The reasons for insufficient success of therapy however lie not only in the illness as such. This study is intended to examine the changes in the subjective success parameters of pain-related impairment and the ability to function in herniated disc patients during rehabilitation. Using multivariate analyses, the influence of sociodemographic, illness-specific, work-related and mental variables on changes in goal variables is shown. 214 herniated disc patients were interviewed before the operation, after post-operative therapy, and six months after surgery. Before their operation, herniated disc patients experienced a severe limitation of activity and ability in everyday function due to pain. About three-fourth of the patients experienced significant improvement in both variables after the operation and post-operative therapy. The influence factors for a successful therapy outcome were male gender and higher educational level. Risk factors were increasing age, a desire for a pension, severe illness symptoms and severe pre-operative depression. In addition to somatic therapy, higher risk patients should receive psychological or social and employment counselling as a support to post-operative therapy. PMID:18188804

  10. The Gaia-ESO Survey: New constraints on the Galactic disc velocity dispersion and its chemical dependencies

    NASA Astrophysics Data System (ADS)

    Guiglion, G.; Recio-Blanco, A.; de Laverny, P.; Kordopatis, G.; Hill, V.; Mikolaitis, Š.; Minchev, I.; Chiappini, C.; Wyse, R. F. G.; Gilmore, G.; Randich, S.; Feltzing, S.; Bensby, T.; Flaccomio, E.; Koposov, S. E.; Pancino, E.; Bayo, A.; Costado, M. T.; Franciosini, E.; Hourihane, A.; Jofré, P.; Lardo, C.; Lewis, J.; Lind, K.; Magrini, L.; Morbidelli, L.; Sacco, G. G.; Ruchti, G.; Worley, C. C.; Zaggia, S.

    2015-11-01

    Context. Understanding the history and the evolution of the Milky Way is one of the main goals of modern astrophysics. In particular, the formation of the Galactic disc is a key problem of Galactic archaeology. Aims: We study the velocity dispersion behaviour of Galactic disc stars as a function of the [Mg/Fe] ratio, which for small metallicity bins can be used as a proxy of relative age. This key relation is essential to constrain the formation mechanisms of the disc stellar populations as well as the cooling and settling processes. Methods: We used the recommended parameters and chemical abundances of 7800 FGK Milky Way field stars from the second internal data release of the Gaia-ESO spectroscopic Survey. These stars were observed with the GIRAFFE spectrograph (HR10 and HR21 setups), and cover a large spatial volume in the intervals 6 disc sequence in the [Mg/Fe] vs. [Fe/H] plane. Results: From analysing the Galactocentric velocity of the stars for the thin disc, we find a weak positive correlation between V? and [Fe/H] that is due to a slowly rotating [Fe/H]-poor tail. For the thick disc stars, a strong correlation with [Fe/H] and [Mg/Fe] is established. In addition, we have detected an inversion of the velocity dispersion trends with [Mg/Fe] for thick-disc stars with [Fe/H] < -0.10 dex and [Mg/Fe] > +0.20 dex for the radial component. First, the velocity dispersion increases with [Mg/Fe] at all [Fe/H] ratios for the thin-disc stars, and then it decreases for the thick-disc population at the highest [Mg/Fe] abundances. Similar trends are observed for several bins of [Mg/Fe] within the errors for the azimuthal velocity dispersion, while a continuous increase with [Mg/Fe] is observed for the vertical velocity dispersion. The velocity dispersion decrease agrees with previous measurements of the RAVE survey, although it is observed here for a greater metallicity interval and a larger spatial volume. Conclusions: Thanks to the Gaia-ESO Survey data, we confirm the existence of [Mg/Fe]-rich thick-disc stars with cool kinematics in the generally turbulent context of the primitive Galactic disc. This is discussed in the framework of the different disc formation and evolution scenarios. Based on observations collected with the FLAMES spectrograph at the VLT/UT2 telescope (Paranal Observatory, ESO, Chile), for the Gaia-ESO Large Public Survey, programme 188.B-3002

  11. Evolution of Accretion Discs around a Kerr Black Hole using Extended Magnetohydrodynamics

    E-print Network

    Francois Foucart; Mani Chandra; Charles F. Gammie; Eliot Quataert

    2015-11-13

    Black holes accreting well below the Eddington rate are believed to have geometrically thick, optically thin, rotationally supported accretion discs in which the Coulomb mean free path is large compared to $GM/c^2$. In such an environment, the disc evolution may differ significantly from ideal magnetohydrodynamic predictions. We present non-ideal global axisymmetric simulations of geometrically thick discs around a rotating black hole. The simulations are carried out using a new code ${\\rm\\it grim}$, which evolves a covariant extended magnetohydrodynamics model derived by treating non-ideal effects as a perturbation of ideal magnetohydrodynamics. Non-ideal effects are modeled through heat conduction along magnetic field lines, and a difference between the pressure parallel and perpendicular to the field lines. The model relies on an effective collisionality in the disc from wave-particle scattering and velocity-space (mirror and firehose) instabilities. We find that the pressure anisotropy grows to match the magnetic pressure, at which point it saturates due to the mirror instability. The pressure anisotropy produces outward angular momentum transport with a magnitude comparable to that of MHD turbulence in the disc, and a significant increase in the temperature in the wall of the jet. We also find that, at least in our axisymmetric simulations, conduction has a small effect on the disc evolution because (1) the heat flux is constrained to be parallel to the field and the field is close to perpendicular to temperature gradients, and (2) the heat flux is choked by an increase in effective collisionality associated with the mirror instability.

  12. Indications for Lumbar Total Disc Replacement: Selecting the Right Patient with the Right Indication for the Right Total Disc

    PubMed Central

    Guyer, Richard D.; Ohnmeiss, Donna D.

    2014-01-01

    Summary of Background Data As with any surgery, care should be taken to determine patient selection criteria for lumbar TDR based on safety and optimizing outcome. These goals may initially be addressed by analyzing biomechanical implant function and early clinical experience, ongoing evaluation is needed to refine indications. Objective The purpose of this work was to synthesize information published on general indications for lumbar TDR. A secondary objective was to determine if indications vary for different TDR designs. Methods A comprehensive literature search was conducted to identify lumbar TDR articles. Articles were reviewed and patient selection criteria and indications were synthesized. Results With respect to safety, there was good agreement in the literature to exclude patients with osteopenia/osteoporosis or fracture. Risk of injury to vascular structures due to the anterior approach was often addressed by excluding patients with previous abdominal surgery in the area of disc pathology or increased age. The literature was very consistent on the primary indication for TDR being painful disc degeneration unresponsive to at least 6 months of nonoperative care. Literature investigating the impact of previous spine surgery was mixed; however, prior surgery was not necessarily a contra-indication, provided the patient otherwise met selection criteria. The literature was mixed on setting a minimum preoperative disc height as a selection criterion. There were no publications investigating whether some patients are better/worse candidates for specific TDR designs. Based on the literature a proposal for patient selection criteria is offered. Conclusions Several TDR indications and contra-indications are widely accepted. No literature addresses particular TDR design being preferable for some patients. As with any spine surgery, ongoing evaluation of TDR outcomes will likely lead to more detailed general and device design specific indications. PMID:25694946

  13. Magnetically driven accretion in protoplanetary discs

    NASA Astrophysics Data System (ADS)

    Simon, Jacob B.; Lesur, Geoffroy; Kunz, Matthew W.; Armitage, Philip J.

    2015-11-01

    We characterize magnetically driven accretion at radii between 1 and 100 au in protoplanetary discs, using a series of local non-ideal magnetohydrodynamic (MHD) simulations. The simulations assume a minimum mass solar nebula (MMSN) disc that is threaded by a net vertical magnetic field of specified strength. Confirming previous results, we find that the Hall effect has only a modest impact on accretion at 30 au, and essentially none at 100 au. At 1-10 au the Hall effect introduces a pronounced bimodality in the accretion process, with vertical magnetic fields aligned to the disc rotation supporting a strong laminar Maxwell stress that is absent if the field is anti-aligned. In the anti-aligned case, we instead find evidence for bursts of turbulent stress at 5-10 au, which we tentatively identify with the non-axisymmetric Hall-shear instability. The presence or absence of these bursts depends upon the details of the adopted chemical model, which suggests that appreciable regions of actual protoplanetary discs might lie close to the borderline between laminar and turbulent behaviour. Given the number of important control parameters that have already been identified in MHD models, quantitative predictions for disc structure in terms of only radius and accretion rate appear to be difficult. Instead, we identify robust qualitative tests of magnetically driven accretion. These include the presence of turbulence in the outer disc, independent of the orientation of the vertical magnetic fields, and a Hall-mediated bimodality in turbulent properties extending from the region of thermal ionization to 10 au.

  14. SDSSJ084539.17+225728.0: the first DBZ white dwarf with a metal-rich gaseous debris disc

    E-print Network

    B. T. Gaensicke; D. Koester; T. R. Marsh; A. Rebassa-Mansergas; J. Southworth

    2008-09-15

    We report the discovery of a third white dwarf hosting a gaseous debris disc, SDSSJ084539.17+225728.0. The typical double-peaked CaII 8498,8542,8662A emission lines can be modelled in terms of a Keplerian gas disc with a radial extent from ~0.5Rsun to ~1.0. The effective temperature of SDSS0845+2257, Teff=18600+-500K, is comparable to the two other white dwarfs with gaseous discs, SDSS1043+0855 and SDSS1228+1040, and hence substantially hotter than the bulk of white dwarfs where dusty debris discs were identified through the presence of infrared excess flux. This may suggest that the conditions to produce emission lines from debris discs in the optical wavelength range are only met for a relatively narrow range in Teff. The observed asymmetry in the line profiles indicates a substantial eccentricity in the disc. Two spectra obtained four years apart reveal a significant change in the shapes and equivalent widths of the line profiles, implying that the circumstellar disc evolves on relatively short time scales. In contrast to SDSS1043+0855 and SDSS1228+1040, SDSS0845+2257 has a helium-dominated atmosphere. We detect photospheric absorption lines of He, Ca, Mg, and Si in the Sloan Digital Sky Survey spectrum, and hence classify SDSS0845+2257 as DBZ white dwarf. The abundances for the three metals determined from model atmosphere fits are Ca/He~1.3x10^-7, Mg/He~6.0x10^-6, and Si/He~8.0x10^-6. From the non-detection of Halpha we derive H/He~1000 times lower than in the Sun. This lends strong support to the hypothesis that the gaseous and dusty debris discs found around roughly a dozen white dwarfs originate from the disruption of rocky planetary material.

  15. Disc valve for sampling erosive process streams

    DOEpatents

    Mrochek, J.E.; Dinsmore, S.R.; Chandler, E.W.

    1986-01-07

    A four-port disc valve is described for sampling erosive, high temperature process streams. A rotatable disc defining opposed first and second sampling cavities rotates between fired faceplates defining flow passageways positioned to be alternatively in axial alignment with the first and second cavities. Silicon carbide inserts and liners composed of [alpha] silicon carbide are provided in the faceplates and in the sampling cavities to limit erosion while providing lubricity for a smooth and precise operation when used under harsh process conditions. 1 fig.

  16. Retrolisthesis and Lumbar Disc Herniation: A Pre-operative Assessment of Patient Function

    PubMed Central

    Shen, Michael; Razi, Afshin; Lurie, Jon D.; Hanscom, Brett; Weinstein, Jim

    2008-01-01

    BACKGROUND CONTEXT Retrolisthesis is relatively rare but when present has been associated with increased back pain and impaired back function. Neither the prevalence of this condition in individuals with lumbar disc herniations nor its possible relation to pre-operative back pain and dysfunction has been well studied. PURPOSE The purposes of this study were as follows: 1) to determine the prevalence of retrolisthesis (alone or in combination with other degenerative conditions) in individuals with confirmed L5 – S1 disc herniation who later underwent lumbar discectomy; 2) to determine if there is any association between retrolisthesis and degenerative changes within the same vertebral motion segment; and 3) to determine the relation between retrolisthesis (alone or in combination with other degenerative conditions) and pre-operative low back pain, physical function, and quality of life. STUDY DESIGN/SETTING Cross-sectional study. PATIENT SAMPLE A total of 125 individuals were identified for incorporation into this study. All patients had confirmed L5-S1 disc herniation on MRI and later underwent L5-S1 discectomy. All patients were enrolled in the SPORT (Spine Patient Outcomes Research Trial) study; data was obtained from the multi-institutional database comprised of SPORT patients from across the United States. OUTCOME MEASURES Retrolisthesis, Degenerative change on MRI, Modic Changes. METHODS MRI scans of the lumbar spine were assessed at spinal level L5–S1 for all 125 patients. Retrolisthesis was defined as posterior subluxation of 8% or more. Disc degeneration was defined as any loss of disc signal on T2 imaging. Modic changes were graded 1 – 3 and collectively classified as vertebral endplate degenerative changes. The presence of facet arthropathy and ligamentum flavum hypertrophy were classified jointly as posterior degenerative changes. RESULTS The overall incidence of retrolisthesis at L5-S1 in our study was 23.2%. Retrolisthesis combined with posterior degenerative changes, degenerative disc disease, or vertebral endplate changes had incidences of 4.8%, 16%, and 4.8% respectively. The prevalence of retrolisthesis did not vary by sex, age, race, smoking status, or education level when compared to individuals with normal sagittal alignment. However, individuals with retrolisthesis were more likely to be receiving worker compensation than those without retrolisthesis. Increased age was found to be associated with individuals having vertebral endplate degenerative changes (both alone and in conjunction with retrolisthesis) and degenerative disc disease. Individuals who had retrolisthesis with concomitant vertebral endplate degenerative changes were more often smokers and had no insurance. The presence of retrolisthesis was not associated with an increased incidence of having degenerative disc disease, posterior degenerative changes, or vertebral endplate changes. No statistical significance was found between the presence of retrolisthesis on the degree of patient pre-operative low back pain and physical function. Patients with degenerative disc disease were found to have increased leg pain compared to those patients without degenerative disc changes. CONCLUSIONS We found no significant relationship between retrolisthesis in patients with L5-S1 disc herniation and worse baseline pain or function. It is possible that the contribution of pain or dysfunction related to retrolisthesis was far overshadowed by the presence of symptoms due to the concomitant disc herniation. It remains to be seen whether retrolisthesis will affect outcome following discectomy in these patients. PMID:17630138

  17. Pushing the limits of optical storage

    NASA Astrophysics Data System (ADS)

    van Haaren, J. A. M. M.

    2005-09-01

    Philips Research has been working on improvements of optical disc storage technology for three decades. In this period, optical discs have become the technology of choice for storing and sharing of data on removable media. In 30 years we have made an improvement of about 2 orders of magnitude in both data rate and storage density. The new Blu-ray Disc (BD) optical storage system offers 25 GB on a single layer, with 36 Mbps base data rate. Philips has made an optical pick-up unit with a single lens and a single detector that can be used for BD as well as for DVD and CD. We doubled the BD-storage capacity and increased the data rate by another order of magnitude in our two-dimensional optical storage format TwoDOS. Furthermore, we are exploring near-field optical storage for capacities beyond Blu-ray Disc. By using a solid immersion lens in a conventional actuator, we have realized an experimental laboratory system with remarkable robustness. We have found that near-field optical storage may be used on discs that have a cover layer to protect the data from scratches.

  18. Viscoelastic Disc Arthroplasty Provides Superior Back and Leg Pain Relief in Patients with Lumbar Disc Degeneration Compared to Anterior Lumbar Interbody Fusion

    PubMed Central

    Rischke, Burkhard; Smith, Eric

    2015-01-01

    Background Lumbar disc degeneration (LDD) is one of the most frequently diagnosed spinal diseases. The symptoms these disorders cause are anticipated to increase as the population in Western countries ages. Purpose Compare back and leg pain alleviation in patients with LDD and a viscoelastic disc prosthesis documented in the SWISSspine registry versus patients with anterior lumbar interbody fusion documented in the Spine Tango registry. Study Design Prospectively collected clinical and outcome data in two independent spine registries. Outcome Measures were back and leg pain relief on 0 to 10 numerical rating scales. Materials and Methods The analysis included a single surgeon series of 48 patients with viscoelastic total disc replacement (VTDR) from the SWISSspine registry which were compared to 131 patients with anterior lumbar interbody fusion (ALIF) from the Spine Tango registry. Two linear multivariate regression models were built to assess the associations of patient characteristics with back and leg pain relief. The following covariates were included in the models: patient age and sex, disc herniation as additional diagnosis, number of treated segments, level of treated segment, treatment type (VTDR, ALIF), preoperative back and leg pain levels and follow-up interval. Results Both models showed VTDR to be associated with significantly higher back (2.76 points; 95% confidence interval (CI) 1.78 - 3.73; p < 0.001) and leg pain (2.12 points; 95% CI 1.12 to 3.13; p < 0.001) relief than ALIF. Other influential factors for higher back pain relief were female sex compared with male sex (1.03 additional points; 95% CI 0.27 to 1.78; p = 0.008), monosegmental surgery compared with bisegmental surgery (1.02 additional points; 95% CI 0.21 to 1.83; p = 0.014), and higher back pain at baseline (0.87 points additional pain relief per level of preoperative back pain; 95% CI 0.70 to 1.03; p < 0.001). Other influential factors for leg pain relief were monosegmental surgery (0.93 additional points; 95% CI 0.10 to 1.77; p = 0.029) and higher leg pain at baseline (0.83 points additional pain relief per level of preoperative leg pain; 95% CI 0.70 to 0.96). In both models the L3/4 segment showed 2.36 points (95% CI -4.27 to -0.45; p = 0.016) and 3.69 points (95% CI -5.66 to -1.71; p < 0.001) less pain relief than L5/S1. Discussion Significantly higher back and leg pain relief were observed after viscoelastic total disc replacement in comparison with anterior lumbar interbody fusion. The new less rigid materials used in the second generation total disc replacements (TDRs) may make artificial disc replacement an increasingly attractive option for patients with degenerative lumbar disc disease. Further controlled and long-term follow-up studies are required for more detailed comparisons of the outcomes of these types of disc implants. The Freedom Lumbar Disc is limited by U.S. federal law to investigational use only. PMID:26196033

  19. ORNL concept would greatly increase optical data storage

    SciTech Connect

    Not Available

    1990-01-01

    ORNL researchers have developed a technique, surface-enhanced Raman optical data storage (SERODS), which uses the light-emitting properties of molecules to pack considerably more information into compact discs. This new technology has the potential to store 10 days of music-instead of just 90 minutes-on a single disc.

  20. The Transition between the Inner Disc and the Innermost Galactic Regions

    NASA Astrophysics Data System (ADS)

    Bono, G.; Genovali, K.; Lemasle, B.; Romaniello, M.; Nonino, M.; Bergemann, M.; Buonanno, R.; Fabrizio, M.; François, P.; Inno, L.; Laney, C.; Matsunaga, N.; Pedicelli, S.; Primas, F.; Thévenin, F.

    2015-05-01

    We discuss the iron and the ?-element gradients in the Galactic disc and in the innermost Galactic regions (bulge, bar, nuclear bulge). Accurate spectroscopic measurements of young stellar tracers show a well defined iron gradient between the inner and the outer disc. The same outcome applies to light, ?, and heavy elements. Moreover, the [?/Fe] ratio attains solar values over a significant fraction of the disc, in the bar and in the nuclear bulge. Thus suggesting that the slopes of iron and ?-elements attain quite similar values. There is evidence of a mild enhancement in the outer disc, but this is the consequence of the steady decrease in iron abundance. Current findings do not allow us to constrain whether the chemical enrichment in the nuclear bulge and in the bar is currently driven by bar instabilities. The recent results by the ARGOS spectroscopic survey of intermediate-age stellar tracers (red clump) suggest that the metal-rich stellar components associated with the boxy/peanut bulge show evidence of a mild iron gradient, while the metal-poor component associated with the thick disc/halo shows a flat iron distribution across the bulge. The [?/Fe] ratio of the metal-rich components is slightly enhanced in the bulge, but attains a solar value in the disc. On the other hand, the metal-poor component is ?-enhanced both in the bulge and at larger Galactocentric distances. The chemical enrichment history of the bulge supports N-body simulations suggesting that the bulge formed via a bar-forming and bar-buckling instabilities (Ness et al. 2013a,b).

  1. Generalized Joint Laxity is Associated with Primary Occurrence and Treatment Outcome of Lumbar Disc Herniation

    PubMed Central

    Han, Woo Jin; Kim, Hong-Bae; Lee, Gun Woo; Choi, Jung Heum; Jo, Won Jin

    2015-01-01

    Background We investigated relationships between generalized joint laxity and primary lumbar disc herniation occurrence and compared clinical outcomes after conservative treatment in lumbar disc herniation patients with and without generalized joint laxity. Methods The study group included 128 men, and the control group included 276 men matched for age and body mass index with the study group. The primary outcome measure was the presence or absence of generalized joint laxity using the Beighton scale. Clinical outcomes measured by the visual analog scale and the Oswestry disability index 2 years after conservative treatment were the secondary outcome measure. Results Generalized joint laxity prevalence was 13.2% in the study group and 5.1% in the control group, a significant difference (P=0.01). Spearman correlation analysis revealed that weight (r=0.162, P=0.03), body mass index (r=0.131, P=0.03), and generalized joint laxity (r=0.372, P<0.01) significantly correlated with lumbar disc herniation occurrence. In multivariate regression analysis, generalized joint laxity was the only significant lumbar disc herniation predictor (P=0.002; 95% confidence interval, 1.08 to 5.26). Generalized joint laxity in lumbar disc herniation patients was associated with worse clinical outcomes after conservative treatment measured by visual analog scale scores for lower extremity pain (P=0.02), lower back pain (P=0.03), and Oswestry disability index scores (P=0.03). Conclusion Generalized joint laxity might be associated with lumbar disc herniation occurrence and might also be a negative predictor of worse clinical outcomes after conservative treatment. PMID:26019764

  2. Evidence for temporal evolution in the M33 disc as traced by its star clusters

    E-print Network

    Beasley, Michael A; Gallart, Carme; Sarajedini, Ata; Aparicio, Antonio

    2015-01-01

    We present precision radial velocities and stellar population parameters for 77 star clusters in the Local Group galaxy M33. Our GTC and WHT observations sample both young, massive clusters and known/candidate globular clusters, spanning ages ~ 10^6 - 10^10 yr, and metallicities, [M/H] ~-1.7 to solar. The cluster system exhibits an age-metallicity relation; the youngest clusters are the most metal-rich. When compared to HI data, clusters with [M/H] ~ -1.0 and younger than ~ 4 Gyr are clearly identified as a disc population. The clusters show evidence for strong time evolution in the disc radial metallicity gradient (d[M/H]dt / dR = 0.03 dex/kpc/Gyr). The oldest clusters have stronger, more negative gradients than the youngest clusters in M33. The clusters also show a clear age-velocity dispersion relation. The line of sight velocity dispersions of the clusters increases with age similar to Milky Way open clusters and stars. The general shape of the relation is reproduced by disc heating simulations, and the s...

  3. The Gaia-ESO Survey: Insights into the inner-disc evolution from open clusters

    NASA Astrophysics Data System (ADS)

    Magrini, L.; Randich, S.; Donati, P.; Bragaglia, A.; Adibekyan, V.; Romano, D.; Smiljanic, R.; Blanco-Cuaresma, S.; Tautvaišien?, G.; Friel, E.; Overbeek, J.; Jacobson, H.; Cantat-Gaudin, T.; Vallenari, A.; Sordo, R.; Pancino, E.; Geisler, D.; San Roman, I.; Villanova, S.; Casey, A.; Hourihane, A.; Worley, C. C.; Francois, P.; Gilmore, G.; Bensby, T.; Flaccomio, E.; Korn, A. J.; Recio-Blanco, A.; Carraro, G.; Costado, M. T.; Franciosini, E.; Heiter, U.; Jofré, P.; Lardo, C.; de Laverny, P.; Monaco, L.; Morbidelli, L.; Sacco, G.; Sousa, S. G.; Zaggia, S.

    2015-08-01

    Context. The inner disc, which links the thin disc with the bulge, has been somewhat neglected in the past because of the intrinsic difficulties in its study, among which crowding and high extinction. Open clusters located in the inner disc are among thebest tracers of its chemistry at different ages and distances. Aims: We analyse the chemical patterns of four open clusters located within 7 kpc of the Galactic centre and of field stars to infer the properties of the inner disc with the Gaia-ESO survey idr2/3 data release. Methods: We derive the parameters of the newly observed cluster, Berkeley 81, finding an age of about 1 Gyr and a Galactocentric distance of ~5.4 kpc. We construct the chemical patterns of clusters and we compare them with those of field stars in the solar neighbourhood and in the inner-disc samples. Results: Comparing the three populations we observe that inner-disc clusters and field stars are both, on average, enhanced in [O/Fe], [Mg/Fe], and [Si/Fe]. Using the idr2/3 results of M67, we estimate the non-local thermodynamic equilibrium (NLTE) effect on the abundances of Mg and Si in giant stars. After empirically correcting for NLTE effects, we note that NGC 6705 and Be 81 still have a high [?/Fe]. Conclusions: The location of the four open clusters and of the field population reveals that the evolution of the metallicity [Fe/H] and of [?/Fe] can be explained within the framework of a simple chemical evolution model: both [Fe/H] and [?/Fe] of Trumpler 20 and of NGC 4815 are in agreement with expectations from a simple chemical evolution model. On the other hand, NGC 6705, and to a lesser degree Berkeley 81, have higher [?/Fe] than expected for their ages, location in the disc, and metallicity. These differences might originate from local enrichment processes as explained in the inhomogeneous evolution framework. Based on observations collected with the FLAMES spectrograph at VLT/UT2 telescope (Paranal Observatory, ESO, Chile), for the Gaia-ESO Large Public Survey (188.B-3002).

  4. Optical Coherence Tomography Updates on Clinical and Technical Developments. Age-Related Macular Degeneration: Drusen and Geographic Atrophy

    NASA Astrophysics Data System (ADS)

    Fleckenstein, Monika; Schmitz-Valckenberg, Steffen; Holz, Frank G.

    Age-related macular degeneration (AMD) is a complex disease with both genetic and environmental factors influencing its development. With the advent of high-resolution OCT imaging, the characterization of drusen in AMD has become possible. The in vivo morphologic characteristics imaged with SD-OCT may represent distinct subclasses of drusen variants, may relate closely to ultrastructural drusen elements identified in donor eyes, and may be useful imaging biomarkers for disease severity or risk of progression [Khanifar et al. Ophthalmology 115(11):1883-1890, 2008].

  5. DISC1–ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1

    E-print Network

    Ishizuka, K

    Disrupted-In-Schizophrenia 1 (DISC1), a risk factor for major mental illnesses, has been studied extensively in the context of neurodevelopment. However, the role of DISC1 in neuronal signaling, particularly in conjunction ...

  6. Measuring cone density in a Japanese macaque (Macaca fuscata) model of age-related macular degeneration with commercially available adaptive optics.

    PubMed

    Pennesi, Mark E; Garg, Anupam K; Feng, Shu; Michaels, Keith V; Smith, Travis B; Fay, Jonathan D; Weiss, Alison R; Renner, Laurie M; Hurst, Sawan; McGill, Trevor J; Cornea, Anda; Rittenhouse, Kay D; Sperling, Marvin; Fruebis, Joachim; Neuringer, Martha

    2014-01-01

    The aim of this study was to assess the feasibility of using a commercially available high-resolution adaptive optics (AO) camera to image the cone mosaic in Japanese macaques (Macaca fuscata) with dominantly inherited drusen. The macaques examined develop drusen closely resembling those seen in humans with age-related macular degeneration (AMD). For each animal, we acquired and processed images from the AO camera, montaged the results into a composite image, applied custom cone-counting software to detect individual cone photoreceptors, and created a cone density map of the macular region. We conclude that flood-illuminated AO provides a promising method of visualizing the cone mosaic in nonhuman primates. Future studies will quantify the longitudinal change in the cone mosaic and its relationship to the severity of drusen in these animals. PMID:24664712

  7. Prognosis of intervertebral disc loss from diagnosis of degenerative disc disease

    NASA Astrophysics Data System (ADS)

    Li, S.; Lin, A.; Tay, K.; Romano, W.; Osman, Said

    2015-03-01

    Degenerative Disc Disease (DDD) is one of the most common causes of low back pain, and is a major factor in limiting the quality of life of an individual usually as they enter older stages of life, the disc degeneration reduces the shock absorption available which in turn causes pain. Disc loss is one of the central processes in the pathogenesis of DDD. In this study, we investigated whether the image texture features quantified from magnetic resonance imaging (MRI) could be appropriate markers for diagnosis of DDD and prognosis of inter-vertebral disc loss. The main objective is to use simple image based biomarkers to perform prognosis of spinal diseases using non-invasive procedures. Our results from 65 subjects proved the higher success rates of the combination marker compared to the individual markers and in the future, we will extend the study to other spine regions to allow prognosis and diagnosis of DDD for a wider region.

  8. AIRS Data Products at GES DISC DAAC

    NASA Technical Reports Server (NTRS)

    2003-01-01

    This list contains the names and some characteristics of Atmospheric InfraRed Sounder (AIRS) data products at the Goddard Earth Sciences (GES) Data and Information Services Center (DISC) Distributed Active Archive Center (DAAC). The list includes variables, units, dimensions, and descriptions for each of the data products, which include infrared radiances and brightness temperatures.

  9. DISC-BASED IMMUNOASSAY MICROARRAYS. (R825433)

    EPA Science Inventory

    Microarray technology as applied to areas that include genomics, diagnostics, environmental, and drug discovery, is an interesting research topic for which different chip-based devices have been developed. As an alternative, we have explored the principle of compact disc-based...

  10. The Astral Curved Disc of Chevroches (France)

    NASA Astrophysics Data System (ADS)

    Devevey, F. Rousseau, A.

    2009-08-01

    The excavation of the unexplored secondary agglomeration in Chevroches (Nièvre), from 2001 to 2002, directed by F. Devevey (INRAP), has led to the discovery of an astrological bronze curved disc of a type unknown in the ancient world; it is inscribed with three lines in Greek transcribing Egyptian an Roman months, and the twelve signs of the zodiac. This article presents the first observations.

  11. On the convective overstability in protoplanetary discs

    NASA Astrophysics Data System (ADS)

    Latter, Henrik N.

    2016-01-01

    This paper explores the driving of low-level hydrodynamical activity in protoplanetary-disc dead zones. A small adverse radial entropy gradient, ordinarily stabilized by rotation, excites oscillatory convection (`convective overstability') when thermal diffusion, or cooling, is neither too strong nor too weak. I revisit the linear theory of the instability, discuss its prevalence in protoplanetary discs, and show that unstable modes are exact non-linear solutions in the local Boussinesq limit. Overstable modes cannot grow indefinitely, however, as they are subject to a secondary parametric instability that limits their amplitudes to relatively low levels. If parasites set the saturation level of the ensuing turbulence then the convective overstability is probably too weak to drive significant angular momentum transport or to generate vortices. But I also discuss an alternative, and far more vigorous, saturation route that generates radial `layers' or `zonal flows' (witnessed in semiconvection). Numerical simulations are required to determine which outcome is favoured in realistic discs, and consequently how important the instability is for disc dynamics.

  12. Project DISC: Developing Indian Software Curriculum.

    ERIC Educational Resources Information Center

    Jacobi, Carolyn

    Project DISC (Developing Indian Software Curriculum) was initiated in the Rapid City (South Dakota) school district to improve Native American children's reading and language arts ability and to provide them with microcomputer skills. During the summer of 1982, introductory computer activities were planned, a computer specialist was hired, and…

  13. Spectra of thermally unstable slim discs

    E-print Network

    Ewa Szuszkiewicz; Roberto Turolla; Luca Zampieri

    2000-11-21

    Thermal instability driven by radiation pressure might be relevant for intrinsically bright accreting sources. The most promising candidate where this instability seems to be at work is one of the two known galactic superluminal sources, GRS 1915+105 (Belloni et al. 1997). In spite of being of relevance, this scenario has not yet been confirmed by proper time-dependent modelling. Non-linear time-dependent calculations performed by Szuszkiewicz and Miller (1998) show that thermally unstable discs undergo limit-cycle behaviour with successive evacuation and refilling of the central parts of the disc. This evolution is very similar to the one proposed by Belloni et al. (1997) in their phenomenological model. Further investigations are needed to confirm the thermal instability being operational in this source. First of all the spectra emitted from the disc during its evolution should be calculated and compared with observations. Here such spectra are computed assuming local blackbody emission from the best studied transonic disc model.

  14. Frictional Torque on a Rotating Disc

    ERIC Educational Resources Information Center

    Mungan, Carl E.

    2012-01-01

    Resistance to motion often includes a dry frictional term independent of the speed of an object and a fluid drag term varying linearly with speed in the viscous limit. (At higher speeds, quadratic drag can also occur.) Here, measurements are performed for an aluminium disc mounted on bearings that is given an initial twist and allowed to spin…

  15. Disc valve for sampling erosive process streams

    DOEpatents

    Mrochek, J.E.; Dinsmore, S.R.; Chandler, E.W.

    1984-08-16

    This is a patent for a disc-type, four-port sampling valve for service with erosive high temperature process streams. Inserts and liners of ..cap alpha..-silicon carbide respectively, in the faceplates and in the sampling cavities, limit erosion while providing lubricity for a smooth and precise operation. 1 fig.

  16. Measurement of macular pigment optical density among healthy Chinese people and patients with early-stage age-related macular degeneration

    PubMed Central

    Ren, Xue-Tao; Gu, Hong; Han, Xu; Zhang, Jun-Yan; Li, Xue; Yang, Xiu-Fen; Xu, Jun; Snellingen, Torkel; Liu, Xi-Pu; Wang, Ning-Li; Liu, Ning-Pu

    2015-01-01

    AIM To measure the macular pigment optical density (MPOD) in healthy Chinese people and patients with early age-related macular degeneration (AMD). METHODS Cross-sectional population based study. Demographic and lifestyle characteristics were ascertained by questionnaire. A food frequency questionnaire was completed for all participants. Participants underwent general physical and ophthalmic examinations and MPOD was measured by heterochromatic flicker photometry. Foveal architecture was measured by optical coherence tomography. RESULTS MPOD of 225 participants (122 healthy and 103 early AMD) was 0.48±0.18. Patients with early AMD (0.52±0.19) tended to have higher MPOD levels than healthy people (0.47±0.17), but the difference was not statistically significant (P=0.06). Participants with carrot or corn oil intake every week tended to have higher levels of MPOD (P=0.002 and 0.008 respectively) while those with corn intake had relatively lower level of MPOD (P=0.01). MPOD increased with the center foveal thickness (P=0.01). CONCLUSION Our findings show that there is no statistically significant association between MPOD and early AMD in the studied population. MPOD is related to center foveal thickness and diets would influence MPOD levels. PMID:26682171

  17. Gas dynamics in tidal dwarf galaxies: disc formation at z=0

    E-print Network

    Lelli, F; Brinks, E; Bournaud, F; McGaugh, S S; Lisenfeld, U; Weilbacher, P M; Boquien, M; Revaz, Y; Braine, J; Koribalski, B S; Belles, P -E

    2015-01-01

    Tidal dwarf galaxies (TDGs) are recycled objects that form within the collisional debris of interacting/merging galaxies. They are expected to be devoid of non-baryonic dark matter, since they can form only from dissipative material ejected from the discs of the progenitor galaxies. We investigate the gas dynamics in a sample of six bona-fide TDGs around three interacting and post-interacting systems: NGC 4694, NGC 5291, and NGC 7252 ("Atoms for Peace"). For NGC 4694 and NGC 5291 we analyse existing HI data from the Very Large Array (VLA), while for NGC 7252 we present new HI observations from the Jansky VLA together with long-slit and integral-field optical spectroscopy. For all six TDGs, the HI emission can be described by rotating disc models. These HI discs, however, have undergone less than a full rotation since the time of the interaction/merger event, raising the question of whether they are in dynamical equilibrium. Assuming that these discs are in equilibrium, the inferred dynamical masses are consis...

  18. Outflows from accretion discs formed in neutron star mergers: effect of black hole spin

    NASA Astrophysics Data System (ADS)

    Fernández, Rodrigo; Kasen, Daniel; Metzger, Brian D.; Quataert, Eliot

    2015-01-01

    The accretion disc that forms after a neutron star merger is a source of neutron-rich ejecta. The ejected material contributes to a radioactively powered electromagnetic transient, with properties that depend sensitively on the composition of the outflow. Here, we investigate how the spin of the black hole (BH) remnant influences mass ejection on the thermal and viscous time-scales. We carry out two-dimensional, time-dependent hydrodynamic simulations of merger remnant accretion discs including viscous angular momentum transport and approximate neutrino self-irradiation. The gravity of the spinning BH is included via a pseudo-Newtonian potential. We find that a disc around a spinning BH ejects more mass, up to a factor of several, relative to the non-spinning case. The enhanced mass-loss is due to energy release by accretion occurring deeper in the gravitational potential, raising the disc temperature and hence the rate of viscous heating in regions where neutrino cooling is ineffective. The mean electron fraction of the outflow increases moderately with BH spin due to a highly irradiated (though not neutrino-driven) wind component. While the bulk of the ejecta is still very neutron-rich, thus generating heavy r-process elements, the leading edge of the wind contains a small amount of Lanthanide-free material. This component can give rise to an ?1 d blue optical `bump' in a kilonova light curve, even in the case of prompt BH formation, which may facilitate its detection.

  19. Evaluation of the effect of intravitreal ranibizumab injections in patients with neovascular age related macular degeneration on retinal nerve fiber layer thickness using optical coherence tomography

    PubMed Central

    El-Ashry, Mohamed F; Lascaratos, Gerassimos; Dhillon, Baljean

    2015-01-01

    Purpose To evaluate the effect of repeated intravitreal ranibizumab injections for neovascular age related macular degeneration (nAMD) on the retinal nerve fiber layer (RNFL) thickness using optical coherence tomography. Design A prospective observational cohort study of patients with nAMD. Methods Thirty eyes of 30 patients with nAMD were selected. All patients received three ranibizumab injections and underwent scans using the fast RNFL thickness protocol (Stratus optical coherence tomography) before starting the first injection and 1 month after the third injection. The RNFL thickness measurements prior to the injections and after the third injection were used for the analysis. We also evaluated the effect of the lens status as well as the type of choroidal neovascular membrane on RNFL thickness measurements pre- and post-injection. Pre- and post-injection average and individual quadrant RNFL thickness were measured and statistically analyzed. Results The mean (± standard deviation) pre-injection RNFL thickness was 90.8±18. The mean (± standard deviation) post-injection RNFL thickness was 91.03±15. The pre- and post-injection values of the mean RNFL thickness were not statistically significant. Likewise, the pre- and post-injection values for RNFL thickness in the different quadrants were not statistically significant. There was no statistical significance for the lens status or the type of choroidal neovascular membrane on the RNFL thickness. Conclusion Repeated ranibizumab injections in nAMD appear to have no harmful effect on the RNFL thickness in the short term, in spite of the proven neurotrophic effect of vascular endothelial growth factor. Nevertheless, the safety profile of ranibizumab injections in nAMD needs to be further evaluated in a large multicenter trial with special emphasis on the long-term effects on the retina and optic nerve. PMID:26203216

  20. Evolution of gas in debris discs

    NASA Astrophysics Data System (ADS)

    Kral, Quentin; Wyatt, Mark; Pringle, Jim

    2015-12-01

    A non negligible quantity of gas has been discovered in an increasing number of debris disc systems. ALMA high sensitivity and high resolution is changing our perception of the gaseous component of debris discs as CO is discovered in systems where it should be rapidly photodissociated. It implies that there is a replenishment mechanism and that the observed gas is secondary. Past missions such as Herschel probed the atomic part of the gas through O I and C II emission lines. Gas science in debris discs is still in its infancy, and these new observations raise a handful of questions concerning the mechanisms to create the gas and about its evolution in the planetary system when it is released. The latter question will be addressed in this talk as a self-consistent gas evolution scenario is proposed and is compared to observations for the peculiar case of ? Pictoris.Our model proposes that carbon and oxygen within debris discs are created due to photodissociation of CO which is itself created from the debris disc dust (due to grain-grain collisions or photodesorption). The evolution of the carbon atoms is modelled as viscous spreading, with viscosity parameterised using an ? model. The temperature, ionisation fraction and population levels of carbon are followed with a PDR model called Cloudy, which is coupled to the dynamical viscous ? model. Only carbon gets ionised due to its lower ionisation potential than oxygen. The carbon gas disc can end up with a high ionisation fraction due to strong FUV radiation field. A high ionisation fraction means that the magnetorotational instability (MRI) is very active, so that ? is very high. Gas density profiles can be worked out for different input parameters such as the ? value, the CO input rate, the location of the input and the incoming radiation field. Observability predictions can be made for future observations, and our model is tested on ? Pictoris observations. This new gas evolution model fits the carbon and CO observations in ? Pic and gives a self-consistent scenario that might be at play in all debris discs...

  1. Prognostic Factors for Postsurgical Recovery of Deltoid Palsy due to Cervical Disc Herniations

    PubMed Central

    Chung, Jae-Yoon; Chang, Han; Song, Kyung-Jin; Kim, Jin-Hyok; Hong, Chang-Hwa; Lee, Jung Sub; Lee, Sang-Hun; Song, Kwang-Sup; Yang, Jae Jun; Uh, Jae-Hyung; Kim, Young-Tae; Lee, Jae Min

    2015-01-01

    Study Design Retrospective multicenter study. Purpose We aimed to investigate prognostic factors affecting postsurgical recovery of deltoid palsy due to cervical disc herniation (CDH). Overview of Literature Little information is available about prognostic factors affecting postsurgical recovery of deltoid palsy due to CDH. Methods Sixty-one patients with CDH causing deltoid palsy (less than grade 3) were included in this study: 35 soft discs and 26 hard discs. Average duration of preoperative deltoid palsy was 11.9 weeks. Thirty-two patients underwent single-level surgery, 22 two-level, four three-level, and three four-level. Patients with accompanying myelopathy, shoulder diseases, or peripheral neuropathy were excluded from the study. Results Deltoid palsy (2.4 grades vs. 4.5 grades, p<0.001) and radiculopathy (6.4 points vs. 2.1 points, p<0.001) significantly improved after surgery. Thirty-six of 61 patients (59%) achieved full recovery (grade 5) of deltoid palsy, with an average time of 8.4 weeks. Longer duration of preoperative deltoid palsy and more severe radiculopathy negatively affected the degree of improvement in deltoid palsy. Age, gender, number of surgery level, and disc type did not affect the degree of improvement of deltoid palsy. Contrary to our expectations, severity of preoperative deltoid palsy did not affect the degree of improvement. Due to the shorter duration of preoperative deltoid palsy, in the context of rapid referral, early surgical decompression resulted in significant recovery of more severe grades (grade 0 or 1) of deltoid palsy compared to grade 2 or 3 deltoid palsy. Conclusions Early surgical decompression significantly improved deltoid palsy caused by CDH, irrespective of age, gender, number of surgery level, and disc type. However, longer duration of deltoid palsy and more severe intensity of preoperative radiating pain were associated with less improvement of deltoid palsy postoperatively. PMID:26435786

  2. Stellar populations of bulges in galaxies with a low surface-brightness disc

    NASA Astrophysics Data System (ADS)

    Morelli, L.; Corsini, E. M.; Pizzella, A.; Dalla Bontà, E.; Coccato, L.; Méndez-Abreu, J.

    2015-03-01

    The radial profiles of the H?, Mg, and Fe line-strength indices are presented for a sample of eight spiral galaxies with a low surface-brightness stellar disc and a bulge. The correlations between the central values of the line-strength indices and velocity dispersion are consistent to those known for early-type galaxies and bulges of high surface-brightness galaxies. The age, metallicity, and ?/Fe enhancement of the stellar populations in the bulge-dominated region are obtained using stellar population models with variable element abundance ratios. Almost all the sample bulges are characterized by a young stellar population, on-going star formation, and a solar ?/Fe enhancement. Their metallicity spans from high to sub-solar values. No significant gradient in age and ?/Fe enhancement is measured, whereas only in a few cases a negative metallicity gradient is found. These properties suggest that a pure dissipative collapse is not able to explain formation of all the sample bulges and that other phenomena, like mergers or acquisition events, need to be invoked. Such a picture is also supported by the lack of a correlation between the central value and gradient of the metallicity in bulges with very low metallicity. The stellar populations of the bulges hosted by low surface-brightness discs share many properties with those of high surface-brightness galaxies. Therefore, they are likely to have common formation scenarios and evolution histories. A strong interplay between bulges and discs is ruled out by the fact that in spite of being hosted by discs with extremely different properties, the bulges of low and high surface-brightness discs are remarkably similar.

  3. Enhancement of Overgrowth by Gene Interactions in Lethal(2)giant Discs Imaginal Discs from Drosophila Melanogaster

    PubMed Central

    Buratovich, M. A.; Bryant, P. J.

    1997-01-01

    Recessive lethal mutations of the lethal(2)giant discs (l(2)gd) and lethal(2)fat (l(2)ft) loci of Drosophila melanogaster cause imaginal disc hyperplasia during a prolonged larval stage. Imaginal discs from l(2)ft l(2)gd or Gl(2)gd double homozygotes show more extensive overgrowth than in either single homozygote, and double homozygous l(2)ft l(2)gd mitotic clones in adult flies show much more overgrowth than is seen in clones homozygous for either l(2)gd or l(2)ft alone. dachsous (ds) also acts as an enhancer of l(2)gd, producing dramatically overgrown discs and causing failure to pupariate in double homozygotes. The comb gap (cg) mutation, which also interacts with ds, greatly enhances the tendency of imaginal discs from l(2)gd larvae to duplicate as they overgrow. If l(2)gd homozygotes are made heterozygous for l(2)ft, then several discs duplicate, indicating that l(2)ft acts as a dominant enhancer of l(2)gd. l(2)ft also acts as a dominant enhancer of l(2)gd, and conversely l(2)gd acts as a dominant modifier of l(2)ft. The enhancement of overgrowth caused by various mutant combinations is accompanied by changes in expression of Decapentaplegic and Wingless. These results show that tumor suppressor genes act in combination to control cell proliferation, and that tissue hyperplasia can be associated with ectopic expression of genes involved in pattern formation. PMID:9335602

  4. Influence of blade profile of disc cutter on numerical simulation of the disc slitting process

    NASA Astrophysics Data System (ADS)

    Zeng, J.; Lu, J. B.; Yan, Q. S.; Li, S.

    2015-03-01

    The disc slitting machining experiments for electrical steel sheet were conducted to investigate the wear process of carbide alloy disc cutter and the slitting quality in the disc slitting process, and the blade contour shape of disc cutter in different slitting distance was measured by the surface profiler. A DEFORM-2D model, where the real blade profile or arc fitting profile was used as the blade contour of the cutter, was built to simulate the disc slitting process. Results show that the blade wear of disc cutter increases. The blade wear presents uneven in the side surface and cylindrical surface of the cutter, and the side wear is more serious with the increase of the slitting distance of electrical steel sheet. As the blade wear increases, the height of the rollover increases gradually, the height of the shear area increases at first and then decreases, but the height of the fracture area decreases at first and then increases. Compared with the arc fitting profile, the simulation surface morphology using the real blade profile is in good agreement with the experimental result. The variation of blade profile can change the distribution of the hydrostatic stress of sheet metal and the occurring and propagating of the crack, and the maximum hydrostatic stress can be used to estimate the change tendency of the fracture area.

  5. Collisional dust avalanches in debris discs

    E-print Network

    Anna Grigorieva; Pawel Artymowicz; Philippe Thébault

    2006-09-26

    We quantitatively investigate how collisional avalanches may developin debris discs as the result of the initial break-up of a planetesimal or comet-like object, triggering a collisional chain reaction due to outward escaping small dust grains. We use a specifically developed numerical code that follows both the spatial distribution of the dust grains and the evolution of their size-frequency distribution due to collisions. We investigate how strongly avalanche propagation depends on different parameters (e.g., amount of dust released in the initial break-up, collisional properties of dust grains and their distribution in the disc). Our simulations show that avalanches evolve on timescales of ~1000 years, propagating outwards following a spiral-like pattern, and that their amplitude exponentially depends on the number density of dust grains in the system. We estimate a probability for witnessing an avalanche event as a function of disc densities, for a gas-free case around an A-type star, and find that features created by avalanche propagation can lead to observable asymmetries for dusty systems with a beta Pictoris-like dust content or higher. Characteristic observable features include: (i) a brightness asymmetry of the two sides for a disc viewed edge-on, and (ii) a one-armed open spiral or a lumpy structure in the case of face-on orientation. A possible system in which avalanche-induced structures might have been observed is the edge-on seen debris disc around HD32297, which displays a strong luminosity difference between its two sides.

  6. Age-Related Vitamin D Deficiency Is Associated with Reduced Macular Ganglion Cell Complex: A Cross-Sectional High-Definition Optical Coherence Tomography Study

    PubMed Central

    Uro, Mathieu; Beauchet, Olivier; Cherif, Mehdi; Graffe, Alix; Milea, Dan; Annweiler, Cedric

    2015-01-01

    Background Vitamin D deficiency is associated with smaller volume of optic chiasm in older adults, indicating a possible loss of the visual axons and their cellular bodies. Our objective was to determine whether vitamin D deficiency in older adults is associated with reduced thickness of the ganglion cell complex(GCC) and of the retinal nerve fibre layer(RNFL), as measured with high-definition optical coherence tomography(HD-OCT). Methods Eighty-five French older community-dwellers without open-angle glaucoma and patent age-related macular degeneration(mean, 71.1±4.7years; 45.9%female) from the GAIT study were separated into 2 groups according to serum 25OHD level(i.e., deficient?25nmol/L or sufficient>25nmol/L). Measurements of GCC and RNFL thickness were performed using HD-OCT. Age, gender, body mass index, number of comorbidities, dementia, functional autonomy, intracranial volume, visual acuity, serum calcium concentration and season of testing were considered as potential confounders. Results Mean serum 25OHD concentration was 58.4±26.8nmol/L. Mean logMAR visual acuity was 0.03±0.06. Mean visual field mean deviation was -1.25±2.29dB. Patients with vitamin D deficiency(n=11) had a reduced mean GCC thickness compared to those without vitamin D deficiency(72.1±7.4?m versus 77.5±7.5?m, P=0.028). There was no difference of the mean RNFL thickness in these two groups(P=0.133). After adjustment for potential confounders, vitamin D deficiency was associated with reduced GCC thickness(ß=-5.12, P=0.048) but not RNFL thickness(ß=-9.98, P=0.061). Specifically, vitamin D deficiency correlated with the superior medial GCC area(P=0.017) and superior temporal GCC area(P=0.010). Conclusions Vitamin D deficiency in older patients is associated with reduced mean GCC thickness, which can represent an early stage of optic nerve damage, prior to RNFL loss. PMID:26090872

  7. A REST-FRAME OPTICAL VIEW ON z {approx} 4 GALAXIES. I. COLOR AND AGE DISTRIBUTIONS FROM DEEP IRAC PHOTOMETRY OF THE IUDF10 AND GOODS SURVEYS

    SciTech Connect

    Oesch, P. A.; Illingworth, G. D.; Gonzalez, V.; Holden, B. P.; Magee, D.; Trenti, M.; Van Dokkum, P. G.

    2013-08-01

    We present a study of rest-frame UV-to-optical color distributions for z {approx} 4 galaxies based on the combination of deep HST/ACS+WFC3/IR data with Spitzer/IRAC imaging. In particular, we use new, ultra-deep data from the IRAC Ultradeep Field program (IUDF10), together with previous, public IRAC data over the GOODS fields. Our sample contains a total of {approx}2600 galaxies selected as B-dropout Lyman-break Galaxies in the HUDF and its deep parallel field HUDF09-2, as well as GOODS-North/South. This sample is used to investigate the UV continuum slopes {beta} and Balmer break colors (J{sub 125} - [4.5]) as a function of rest-frame optical luminosity (using [4.5] to avoid optical emission lines). We find that galaxies at M{sub z} < -21.5 (roughly corresponding to L{sup *}{sub z{approx}4}) are significantly redder than their lower luminosity counterparts. The UV continuum slopes and the J{sub 125} - [4.5] colors are well correlated, indicating that the dust reddening at these redshifts is better described by an SMC-like extinction curve, rather than the typically assumed Calzetti reddening. After dust correction, we find that the galaxy population shows mean stellar population ages in the range 10{sup 8.5} to 10{sup 9} yr, with a dispersion of {approx}0.5 dex, and only weak trends as a function of luminosity. Only a small fraction of galaxies shows Balmer break colors consistent with extremely young ages, younger than 100 Myr. Under the assumption of smooth star-formation histories, this fraction is 12%-19% for galaxies at M{sub z} < -19.75. Our results are consistent with a gradual build-up of stars and dust in galaxies at z > 4 with only a small fraction of stars being formed in short, intense bursts of star-formation.

  8. A Rest-frame Optical View on z ~ 4 Galaxies. I. Color and Age Distributions from Deep IRAC Photometry of the IUDF10 and GOODS Surveys

    NASA Astrophysics Data System (ADS)

    Oesch, P. A.; Labbé, I.; Bouwens, R. J.; Illingworth, G. D.; Gonzalez, V.; Franx, M.; Trenti, M.; Holden, B. P.; van Dokkum, P. G.; Magee, D.

    2013-08-01

    We present a study of rest-frame UV-to-optical color distributions for z ~ 4 galaxies based on the combination of deep HST/ACS+WFC3/IR data with Spitzer/IRAC imaging. In particular, we use new, ultra-deep data from the IRAC Ultradeep Field program (IUDF10), together with previous, public IRAC data over the GOODS fields. Our sample contains a total of ~2600 galaxies selected as B-dropout Lyman-break Galaxies in the HUDF and its deep parallel field HUDF09-2, as well as GOODS-North/South. This sample is used to investigate the UV continuum slopes ? and Balmer break colors (J 125 - [4.5]) as a function of rest-frame optical luminosity (using [4.5] to avoid optical emission lines). We find that galaxies at Mz < -21.5 (roughly corresponding to L^*_{z\\sim 4}) are significantly redder than their lower luminosity counterparts. The UV continuum slopes and the J 125 - [4.5] colors are well correlated, indicating that the dust reddening at these redshifts is better described by an SMC-like extinction curve, rather than the typically assumed Calzetti reddening. After dust correction, we find that the galaxy population shows mean stellar population ages in the range 108.5 to 109 yr, with a dispersion of ~0.5 dex, and only weak trends as a function of luminosity. Only a small fraction of galaxies shows Balmer break colors consistent with extremely young ages, younger than 100 Myr. Under the assumption of smooth star-formation histories, this fraction is 12%-19% for galaxies at Mz < -19.75. Our results are consistent with a gradual build-up of stars and dust in galaxies at z > 4 with only a small fraction of stars being formed in short, intense bursts of star-formation. Based on data obtained with the Hubble Space Telescope operated by AURA, Inc. for NASA under contract NAS5-26555. Based on observations with the Spitzer Space Telescope, which is operated by the Jet Propulsion Laboratory, California Institute of Technology under NASA contract 1407.

  9. Evidence for temporal evolution in the M33 disc as traced by its star clusters

    NASA Astrophysics Data System (ADS)

    Beasley, Michael A.; San Roman, Izaskun; Gallart, Carme; Sarajedini, Ata; Aparicio, Antonio

    2015-08-01

    We present precision radial velocities and stellar population parameters for 77 star clusters in the Local Group galaxy M33. Our Gran Telescopio de Canarias and William Herschel Telescope observations sample both young, massive clusters and known/candidate globular clusters (GCs), spanning ages ˜106-1010 yr, and metallicities, [M/H] ˜ -1.7 to solar. The cluster system exhibits an age-metallicity relation; the youngest clusters are the most metal rich. When compared to H I data, clusters with [M/H] ˜ -1.0 and younger than ˜4 Gyr are clearly identified as a disc population. The clusters show evidence for strong time evolution in the disc radial metallicity gradient (d[M/H]dt/dR = 0.03 dex kpc-1 Gyr-1). The oldest clusters have stronger, more negative gradients than the youngest clusters in M33. The clusters also show a clear age-velocity dispersion relation. The line-of-sight velocity dispersions of the clusters increases with age similar to Milky Way open clusters and stars. The general shape of the relation is reproduced by disc heating simulations, and the similarity between the relations in M33 and the Milky Way suggests that heating by substructure and cooling of the interstellar medium both play a role in shaping this relation. We identify 12 `classical' GCs, six of which are newly identified GC candidates. The GCs are more metal rich than Milky Way halo clusters, and show weak rotation. The inner (R < 4.5 kpc) GCs exhibit a steep radial metallicity gradient (d[M/H]/dR = -0.29 ± 0.11 dex kpc-1) and an exponential-like surface density profile. We argue that these inner GCs are thick disc rather than halo objects.

  10. Effect of calcitonin pretreatment on naturally occurring intervertebral disc degeneration in guinea pig

    PubMed Central

    Jiang, Xiaohua; Tian, Faming; Wang, Wenya; Yan, Jinyin; Liu, Huanjiang; Liu, Binbin; Song, Huiping; Zhang, Yingze; Shen, Yong; Zhang, Liu

    2015-01-01

    Introduction: Our previous study suggested protective effects of calcitonin (CT) on experimental osteoarthritis. The aim of the present study was to provide evidence of whether CT pretreatment could prevent naturally occurring intervertebral disc degeneration in guinea pigs. Methods: Forty-two 3 months old female guinea pigs were randomly assigned into 2 groups as follows: Twenty-four were treated by normal saline as control group and sacrificed at 3, 6, 9 and 12 months of age (6 animals at each time point), the other 18 were received salmon CT (8 ug/kg/day, everyday) treatment at 3 months of age and sacrificed at the age of 6, 9 and 12 months respectively. Van Gieson stain and the histological score were used to identify the histological changes of the lumbar intervertebral discs. The disc height and vertebral body height were measured. Immunohistochemistry measurements for glycosaminoglycan, type II collagen, and matrix metalloprotease (MMP)-1 expressions were performed. Bone quality and microstructural changes in the L3-6 lumbar vertebral bodies were assessed by bone mineral density (BMD), micro-CT analysis and biomechanical testing. Results: Histological analysis indicated significantly higher disc degeneration scores in 9-month-old guinea pigs in comparison with younger animals, and grew higher with increasing age. CT treatment significantly reduced the histological score, and increased the disc height and the ratio to vertebral body height in 12 months old animals, as well as upregulated the glycosaminoglycan, type II collagen and inhibited the MMP-1 expression. Micro-CT analysis showed decreased percent bone volume (BV/TV) and increased trabecular separation (Tb.Sp), structural model index (SMI) in 12 months old animals in comparison with the younger animals. Markedly increased BV/TV and decreased Tb.Sp were observed in CT treated animals when compared with control animals. The biomechanical properties including maximum load, maximum stress, yield stress and elastic modulus increased from 3 to 6 months old and thereafter maintained in a stable level, which were enhanced by CT treatment. Conclusion: Pretreatment with CT could prevent naturally occurring intervertebral disc degeneration in guinea pigs, which might be related to the modulation of extracellular matrix metabolism and the integrity and biomechanical properties in adjacent vertebral body. PMID:26379827

  11. Optical DNA

    NASA Astrophysics Data System (ADS)

    Vijaywargi, Deepak; Lewis, Dave; Kirovski, Darko

    A certificate of authenticity (COA) is an inexpensive physical object with a random and unique structure S which is hard to near-exactly replicate. An inexpensive device should be able to scan object’s physical “fingerprint,” a set of features that represents S. In this paper, we explore one set of requirements that optical media such as DVDs should satisfy, to be considered as COAs. As manufacturing of such media produces inevitable errors, we use the locations and count of these errors as a “fingerprint” for each optical disc: its optical DNA. The “fingerprint” is signed using publisher’s private-key and the resulting signature is stored onto the optical medium using a post-production process. Standard DVD players with altered firmware that includes publisher’s public-key, should be able to verify the authenticity of DVDs protected with optical DNA. Our key finding is that for the proposed protocol, only DVDs with exceptional wear-and-tear characteristics would result in an inexpensive and viable anti-counterfeiting technology.

  12. Turbulence-induced disc formation in strongly magnetized cloud cores

    NASA Astrophysics Data System (ADS)

    Seifried, D.; Banerjee, R.; Pudritz, R. E.; Klessen, R. S.

    2013-07-01

    We present collapse simulations of strongly magnetized, turbulent molecular cloud cores with masses ranging from 2.6 to 1000 M? in order to study the influence of the initial conditions on the turbulence-induced disc formation mechanism proposed recently by Seifried et al. We find that Keplerian discs are formed in all cases independently of the core mass, the strength of turbulence or the presence of global rotation. The discs appear within a few kyr after the formation of the protostar, are 50-150 au in size, and have masses between 0.05 and a few 0.1 M?. During the formation of the discs the mass-to-flux ratio stays well below the critical value of 10 for Keplerian disc formation. Hence, flux-loss alone cannot explain the formation of Keplerian discs. The formation of rotationally supported discs at such early phases is rather due to the disordered magnetic field structure and due to turbulent motions in the surroundings of the discs, two effects lowering the classical magnetic braking efficiency. Binary systems occurring in the discs are mainly formed via the disc capturing mechanism rather than via disc fragmentation, which is largely suppressed by the presence of magnetic fields.

  13. Examination of turbine discs from nuclear power plants

    SciTech Connect

    Czajkowski, C.J.; Weeks, J.R.

    1982-01-01

    Investigations were performed on a cracked turbine disc from the Cooper Nuclear Power Station, and on two failed turbine discs (governor and generator ends) from the Yankee-Rowe Nuclear Power Station. Cooper is a boiling water reactor (BWR) which went into commercial operation in July 1974, and Yankee-Rowe is a pressurized water reactor (PWR) which went into commercial operation in June 1961. Cracks were identified in the bore of the Cooper disc after 41,913 hours of operation, and the disc removed for repair. At Yankee-Rowe two discs failed after 100,000 hours of operation. Samples of the Cooper disc and both Yankee-Rowe disc (one from the governor and one from the generator end of the LP turbine) were sent to Brookhaven National Laboratory (BNL) for failure analysis.

  14. Does disc fragmentation prevent the formation of supermassive stars in protogalaxies?

    NASA Astrophysics Data System (ADS)

    Inayoshi, Kohei; Haiman, Zoltán

    2014-12-01

    Supermassive stars (SMSs; ? 105 M?) formed in the first protogalaxies with virial temperature Tvir ? 104 K are expected to collapse into seeds of supermassive black hole in the high-redshift Universe (z ? 7). Fragmentation of the primordial gas is, however, a possible obstacle to SMS formation. We discuss the expected properties of a compact, metal-free, marginally unstable nuclear protogalactic disc, and the fate of the clumps formed in the disc by gravitational instability. Interior to a characteristic radius Rf = few × 10-2 pc, the disc fragments into massive clumps with Mc ˜ 30 M?. The clumps grow via accretion and migrate inward rapidly on a time-scale of ˜104 yr, which is comparable or shorter than the Kelvin-Helmholtz time >104 yr. Some clumps may evolve to zero-age main-sequence stars and halt gas accretion by radiative feedback, but most of the clumps can migrate inward and merge with the central protostar before forming massive stars. Moreover, we found that dust-induced fragmentation in metal-enriched gas does not modify these conclusions unless Z ? 3 × 10- 4 Z?, because clump migration below this metallicity remains as rapid as in the primordial case. Our results suggest that fragmentation of a compact, metal-poor disc cannot prevent the formation of a SMS.

  15. The Star Formation History in The Far Outer Disc of M33

    E-print Network

    Barker, M K; Cole, A A; Ibata, R; Irwin, M; Lewis, G F; Smecker-Hane, T A; Tanvir, N R

    2010-01-01

    The outer regions of disc galaxies are becoming increasingly recognized as key testing sites for models of disc assembly and evolution. Important issues are the epoch at which the bulk of the stars in these regions formed and how discs grow radially over time. To address these issues, we use Hubble Space Telescope Advanced Camera for Surveys imaging to study the star formation history (SFH) of two fields at 9.1 and 11.6 kpc along M33's northern major axis. These fields lie at ~ 4 and 5 V-band disc scale-lengths and straddle the break in M33's surface brightness profile. The colour-magnitude diagrams (CMDs) reach the ancient main sequence turnoff with a signal-to-noise ratio of ~ 5. From detailed modelling of the CMDs, we find that the majority of stars in both fields combined formed at z < 1. The mean age in the inner field, S1, is ~ 3 +/- 1 Gyr and the mean metallicity is [M/H] ~ -0.5 +/- 0.2 dex. The star formation history of S1 unambiguously reveals how the inside-out growth previously measured for M33'...

  16. Level Set Segmentation of Optic Discs from Retinal Images

    E-print Network

    Li, Yongmin

    matching I. INTRODUCTION Glaucoma, predicted to affect about 70 million people around the world by 2020 [1 in glaucoma analysis. Over the past years, glaucoma experts have analysed the amount of cupping using manual

  17. Line and continuum emission from the outer regions of accretion discs in active galactic nuclei. III. Influence of the illumination model

    NASA Astrophysics Data System (ADS)

    Dumont, A. M.; Collin-Souffrin, S.

    1990-03-01

    In this paper we study the influence of the external illumination on the structure of the accretion disc in an Active Galactic Nucleus. We consider two situations: the point source model, where a compact source of non-thermal radiation located at a given height illuminates the disc; the diffusion model, where the radiation of a central source is scattered back towards the disc by a hot diffusing medium The structure of the inner regions of the disc (R < 10^4^ R_G_) is not modified by the presence of an external radiation flux, but a radiatively heated chromosphere is created above the surface. In the outer regions (R > 10^4^ R_G_) the whole disc is radiatively heated. The main result of this study is to show that the ionization parameter in the bulk of the irradiated layers is small. It may be high only in a small external "skin", but in this case the gas undergoes a thermal instability and is heated to a high temperature. As a consequence the disc will mainly emit a Low Ionization spectrum We determine the optical thickness of the Paschen and Balmer continuum and show that the outer regions of the disc are generally transparent in the visible and opaque in the UV, while the inner regions are opaque in both ranges.

  18. Interface Modes and Their Instabilities in Accretion Disc Boundary Layers

    E-print Network

    David Tsang; Dong Lai

    2008-12-20

    We study global non-axisymmetric oscillation modes trapped near the inner boundary of an accretion disc. Observations indicate that some of the quasi-periodic oscillations (QPOs) observed in the luminosities of accreting compact objects (neutron stars, black holes and white dwarfs) are produced in the inner-most regions of accretion discs or boundary layers. Two simple models are considered in this paper: The magnetosphere-disc model consists of a thin Keplerian disc in contact with a uniformly rotating magnetosphere with and low plasma density, while the star-disc model involves a Keplerian disc terminated at the stellar atomosphere with high density and small density scale height. We find that the interface modes at the magnetosphere-disc boundary are generally unstable due to Rayleigh-Taylor and/or Kelvin-Helmholtz instabilities. However, differential rotation of the disc tends to suppress Rayleigh-Taylor instability and a sufficiently high disc sound speed (or temperature) is needed to overcome this suppression and to attain net mode growth. On the other hand, Kelvin-Helmholtz instability may be active at low disc sound speeds. We also find that the interface modes trapped at the boundary between a thin disc and an unmagnetized star do not suffer Rayleigh-Taylor or Kelvin-Helmholtz instability, but can become unstable due to wave leakage to large disc radii and, for sufficiently steep disc density distributions, due to wave absorption at the corotation resonance in the disc. The non-axisymmetric interface modes studied in this paper may be relevant to the high-frequency QPOs observed in some X-ray binaries and in cataclysmic variables.

  19. Low back pain associated with lumbar disc herniation: role of moderately degenerative disc and annulus fibrous tears.

    PubMed

    Yang, Hao; Liu, Hui; Li, Zemin; Zhang, Kuibo; Wang, Jianru; Wang, Hua; Zheng, Zhaomin

    2015-01-01

    Lumbar disc herniation is one of the most common spinal degenerative disorders which may lead to low back pain (LBP) and radicular leg pain. However, it remains difficult to diagnose a degenerative herniated disc as the LBP generator in clinical practice. The purpose of this study is to explore the characteristic changes of a herniated disc causing LBP on MRI and to clarify the underlying role of inflammatory mediators and annulus fibrous (AF) tears in LBP generation associated with disc herniation. We prospectively collected intervertebral disc specimens and MRI from 57 single-segment disc herniation patients with radiculopathy. All subjects were grouped according to LBP occurrence or disc degeneration severity for the comparison of inflammatory mediators' expression and AF tears occurrence (High Intensity Zone, HIZ, on MRI). LBP incidence under circumstances of different degeneration severity with or without HIZ was further analyzed. Both LBP incidence and Inflammatory mediators expression in moderately degenerated group was higher than mildly and severely degenerative groups. HIZ incidence was higher in moderately and severely degenerated groups. LBP incidence in the patients with both moderately degenerated discs and HIZ was 86.7%, much higher than the rest of the patient population. In conclusion, the high expression of inflammatory mediators with AF tears causes LBP associated with disc herniation. Moderately degenerative disc with HIZ is MRI morphological change of herniated disc causing LBP, which can be applied to diagnose LBP. PMID:25932092

  20. Gas dynamics in tidal dwarf galaxies: Disc formation at z = 0

    NASA Astrophysics Data System (ADS)

    Lelli, Federico; Duc, Pierre-Alain; Brinks, Elias; Bournaud, Frédéric; McGaugh, Stacy S.; Lisenfeld, Ute; Weilbacher, Peter M.; Boquien, Médéric; Revaz, Yves; Braine, Jonathan; Koribalski, Bärbel S.; Belles, Pierre-Emmanuel

    2015-12-01

    Tidal dwarf galaxies (TDGs) are recycled objects that form within the collisional debris of interacting and merging galaxies. They are expected to be devoid of non-baryonic dark matter, since they can only form from dissipative material ejected from the discs of the progenitor galaxies. We investigate the gas dynamics in a sample of six bona fide TDGs around three interacting and post-interacting systems: NGC 4694, NGC 5291, and NGC 7252 ("Atoms for Peace"). For NGC 4694 and NGC 5291, we analyse existing H I data from the Very Large Array (VLA), while for NGC 7252 we present new H I observations from the Jansky VLA, together with long-slit and integral-field optical spectroscopy. For all six TDGs, the H I emission can be described by rotating disc models. These H I discs, however, have undergone less than a full rotation since the time of the interaction/merger event, raising the question of whether they are in dynamical equilibrium. Assuming that these discs are in equilibrium, the inferred dynamical masses are consistent with the observed baryonic masses, implying that TDGs are devoid of dark matter. This puts constraints on putative "dark discs" (either baryonic or non-baryonic) in the progenitor galaxies. Moreover, TDGs seem to systematically deviate from the baryonic Tully-Fisher relation. These results provide a challenging test for alternative theories like MOND. Based on observations made with ESO telescopes at Paranal Observatory under programmes 65.O-0563, 67.B-0049, and 083.B-0647.Appendices are available in electronic form at http://www.aanda.orgThe reduced data cubes are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/584/A113

  1. On the convective overstability in protoplanetary discs

    E-print Network

    Latter, Henrik

    2015-01-01

    This paper explores the driving of low-level hydrodynamical activity in protoplanetary-disc dead zones. A small adverse radial entropy gradient, ordinarily stabilised by rotation, excites oscillatory convection (`convective overstability') when thermal diffusion, or cooling, is neither too strong nor too weak. I revisit the linear theory of the instability, discuss its prevalence in protoplanetary discs, and show that unstable modes are exact nonlinear solutions in the local Boussinesq limit. Overstable modes cannot grow indefinitely, however, as they are subject to a secondary parametric instability that limits their amplitudes to relatively low levels. If parasites set the saturation level of the ensuing turbulence then the convective overstability is probably too weak to drive significant angular momentum transport or to generate vortices. But I also discuss an alternative, and far more vigorous, saturation route that generates radial `layers' or `zonal flows' (witnessed also in semiconvection). Numerical ...

  2. Cervical disc arthroplasty: Pros and cons

    PubMed Central

    Moatz, Bradley; Tortolani, P. Justin

    2012-01-01

    Background: Cervical disc arthroplasty has emerged as a promising potential alternative to anterior cervical discectomy and fusion (ACDF) in appropriately selected patients. Despite a history of excellent outcomes after ACDF, the question as to whether a fusion leads to adjacent segment degeneration remains unanswered. Numerous US investigational device exemption trials comparing cervical arthroplasty to fusion have been conducted to answer this question. Methods: This study reviews the current research regarding cervical athroplasty, and emphasizes both the pros and cons of arthroplasty as compared with ACDF. Results: Early clinical outcomes show that cervical arthroplasty is as effective as the standard ACDF. However, this new technology is also associated with an expanding list of novel complications. Conclusion: Although there is no definitive evidence that cervical disc replacement reduces the incidence of adjacent segment degeneration, it does show other advantages; for example, faster return to work, and reduced need for postoperative bracing. PMID:22905327

  3. Material Science in Cervical Total Disc Replacement

    PubMed Central

    Pham, Martin H.; Mehta, Vivek A.; Tuchman, Alexander; Hsieh, Patrick C.

    2015-01-01

    Current cervical total disc replacement (TDR) designs incorporate a variety of different biomaterials including polyethylene, stainless steel, titanium (Ti), and cobalt-chrome (CoCr). These materials are most important in their utilization as bearing surfaces which allow for articular motion at the disc space. Long-term biological effects of implanted materials include wear debris, host inflammatory immune reactions, and osteolysis resulting in implant failure. We review here the most common materials used in cervical TDR prosthetic devices, examine their bearing surfaces, describe the construction of the seven current cervical TDR devices that are approved for use in the United States, and discuss known adverse biological effects associated with long-term implantation of these materials. It is important to appreciate and understand the variety of biomaterials available in the design and construction of these prosthetics and the considerations which guide their implementation. PMID:26523281

  4. New Experiments with Spinning Metallic Discs

    NASA Astrophysics Data System (ADS)

    Mazuruk, Konstantin; Grugel, Richard N.

    2003-01-01

    A number of recent advanced theories related to torsion properties of the space-time matrix predict the existence of an interaction between classically spinning objects. Indeed, some experimental data suggest that spinning magnetic bodies discernibly interact with Earth's natural fields. If there are interactions between rotating bodies then nuclear spins could be used for detection. Thus, assuming a spinning body induces a hypothetical torsion field, a sensor based on the giant magnetoresistance effect would detect local changes. Experimentally, spinning a brass wheel shielded from Earth's magnetic field showed no measurable change in signals; with no shielding a Faraday disc phenomenon was observed. Unexpected experimental measurements from the non-axial Faraday disc configuration were recorded and a theoretical model was derived to explain them.

  5. Material Science in Cervical Total Disc Replacement.

    PubMed

    Pham, Martin H; Mehta, Vivek A; Tuchman, Alexander; Hsieh, Patrick C

    2015-01-01

    Current cervical total disc replacement (TDR) designs incorporate a variety of different biomaterials including polyethylene, stainless steel, titanium (Ti), and cobalt-chrome (CoCr). These materials are most important in their utilization as bearing surfaces which allow for articular motion at the disc space. Long-term biological effects of implanted materials include wear debris, host inflammatory immune reactions, and osteolysis resulting in implant failure. We review here the most common materials used in cervical TDR prosthetic devices, examine their bearing surfaces, describe the construction of the seven current cervical TDR devices that are approved for use in the United States, and discuss known adverse biological effects associated with long-term implantation of these materials. It is important to appreciate and understand the variety of biomaterials available in the design and construction of these prosthetics and the considerations which guide their implementation. PMID:26523281

  6. [Repeated operations for recurrent lumbar disc herniations].

    PubMed

    Kloc, W; Imieli?ski, B L; Wasilewski, W; Jende, P; Puzyrewski, R

    1999-01-01

    A study of 73 patients who underwent reoperation for persistent or new complaints following initial lumbar discectomy is presented. 32 patients showed true recurrence of disc herniation (6 on the contralateral side) and 41 at a different level. 14 patients needed 3rd operation. Final results were evaluated using the Functional Economic Rating Scale elaborated by Prolo. Mean score for group operated on twice was 8.1 according to Prolo and 7.1 for group operated on 3 times. PMID:10791038

  7. Quantified H I morphology - V. H I discs in the Virgo cluster

    NASA Astrophysics Data System (ADS)

    Holwerda, B. W.; Pirzkal, N.; de Blok, W. J. G.; van Driel, W.

    2011-10-01

    We explore the quantified morphology of atomic hydrogen (H I) discs in the Virgo cluster. These galaxies display a wealth of phenomena in their H I morphology, e.g., tails, truncation and warps. These morphological disturbances are related to the ram pressure stripping and tidal interaction that galaxies undergo in this dense cluster environment. To quantify the morphological transformation of the H I discs, we compute the morphological parameters of Concentration, Asymmetry, Smoothness, Gini and M20 and our own GM for 51 galaxies in 48 H I column density maps from the VLA Imaging of Virgo spirals in Atomic gas (VIVA) project. Some morphological phenomena can be identified in this space of relatively low-resolution H I data. Truncation of the H I disc can be cleanly identified via the Concentration parameter (C < 1), and Concentration can also be used to identify H I deficient discs (1 < C < 5). Tidal interaction is typically identified using combinations of these morphological parameters, applied to (optical) images of galaxies. We find that some selection criteria (Gini-M20, Asymmetry and a modified Concentration-M20) are still applicable for the coarse (˜15 arcsec full width at half - maximum) VIVA H I data. We note that Asymmetry is strongly affected by the choice for the centre of these galaxies. The phenomena of tidal tails can be reasonably well identified using the Gini-M20 criterion (60 per cent of galaxies with tails identified but with as many contaminants). Ram pressure does move H I discs into and out of most of our interaction criteria: the ram pressure sequence identified by previous authors tracks into and out of some of these criteria (Asymmetry-based and the Gini-M20 selections, but not the Concentration-M20 or the GM-based ones). Therefore, future searches for interaction using H I morphologies should take ram pressure into account as a mechanism to disturb H I discs enough to make them appear as gravitationally interacting. One mechanism would be to remove all the H I deficient (C < 5) discs from the sample, as these have undergone more than one H I removal mechanism.

  8. Inner disc obscuration in GRS 1915+105 based on relativistic slim disc model

    NASA Astrophysics Data System (ADS)

    Vierdayanti, K.; Sadowski, A.; Mineshige, S.; Bursa, M.

    2013-11-01

    We study the observational signatures of the relativistic slim disc of 10 M? black hole, in a wide range of mass accretion rate, dot{m}, dimensionless spin parameter, a*, and viewing angle, i. In general, the innermost temperature, Tin, increases with the increase of i for a fixed value of dot{m} and a*, due to the Doppler effect. However, for i > 50° and dot{m}>dot{m}_turn, Tin starts to decrease with the increase of dot{m}. This is a result of self-obscuration - the radiation from the innermost hot part of the disc is blocked by the surrounding cooler part. The value of dot{m}_turn and the corresponding luminosities depend on a* and i. Such obscuration effects cause an interesting behaviour on the disc luminosity (Ldisc)-Tin plane for high inclinations. In addition to the standard disc branch which appears below dot{m}_turn and which obeys L_disc ? T_in4 relation, another branch above dot{m}_turn, which is nearly horizontal, may be observed at luminosities close to the Eddington luminosity. We show that these features are likely observed in a Galactic X-ray source, GRS 1915+105. We support a high spin parameter (a* > 0.9) for GRS 1915+105 since otherwise the high value of Tin and small size of the emitting region (rin < 1rS) cannot be explained.

  9. Block and Codeword Interleaving Scheme for the High Density Digital Versatile Disc

    NASA Astrophysics Data System (ADS)

    Hwang, Sung-hee; Lee, Yoon-woo; Han, Sung-hyu; Ryu, Sang-hyun; Park, In-sik; Shin, Dong-ho

    2002-03-01

    The effect of noises from smaller dusts and scratches is higher than the conventional optical storage systems, e.g., compact disc(CD) or digital versatile disc(DVD) by the higher numerical aperture (NA=0.85) and thin cover layer (0.1 mm) of the high density DVD. Accordingly, new error correcting code (ECC) is needed to correct not only both short burst errors and random errors but also long burst errors. So, the interleaving scheme between two ECC blocks is considered to improve the error correction capability. In this paper, we will show our new block and codeword interleaving scheme (BCIS) and calculate the block error rate of BCIS after error correcting by probability method under the error model of Sony’s burst error distribution and compare with the conventional reed-solomon product code(RSPC) of DVD.

  10. Diagnostic methods of a bladed disc mode shape evaluation used for shrouded blades in steam turbines

    NASA Astrophysics Data System (ADS)

    Strnad, Jaromir; Liska, Jindrich

    2015-11-01

    This paper deals with advanced methods for the evaluation of a bladed disc behavior in terms of the wheel vibration and blade service time consumption. These methods are developed as parts of the noncontact vibration monitoring system of the steam turbine shrouded blades. The proposed methods utilize the time-frequency processing (cross spectra) and the method using least squares to analyse the data from the optical and magnetoresistive sensors, which are mounted in the stator radially above the rotor blades. Fundamentally, the blade vibrations are detected during the blade passages under the sensors and the following signal processing, which covers also the proposed methods, leads to the estimation of the blade residual service life. The prototype system implementing above mentioned techniques was installed into the last stage of the new steam turbine (LP part). The methods for bladed disc mode shape evaluation were successfully verified on the signals, which were obtained during the commission operation of the turbine.

  11. On the Eddington limit for relativistic accretion discs

    NASA Astrophysics Data System (ADS)

    Abolmasov, Pavel; Chashkina, Anna

    2015-12-01

    Standard accretion disc model relies upon several assumptions, the most important of which is geometrical thinness. Whenever this condition is violated, new physical effects become important such as radial energy advection and mass loss from the disc. These effects are important, for instance, for large mass accretion rates when the disc approaches its local Eddington limit. In this work, we study the upper limits for standard accretion disc approximation and find the corrections to the standard model that should be considered in any model aiming on reproducing the transition to super-Eddington accretion regime. First, we find that for thin accretion disc, taking into account relativistic corrections allows to increase the local Eddington limit by about a factor of 2 due to stronger gravity in general relativity (GR). However, violation of the local Eddington limit also means large disc thickness. To consider consequently the disc thickness effects, one should make assumptions upon the two-dimensional rotation law of the disc. For rotation frequency constant on cylinders r sin ? = const, vertical gravity becomes stronger with height on spheres of constant radius. On the other hand, effects of radial flux advection increase the flux density in the inner parts of the disc and lower the Eddington limit. In general, the effects connected to disc thickness tend to increase the local Eddington limit even more. The efficiency of accretion is however decreased by advection effects by about a factor of several.

  12. The Photoevaporation of Discs Around Young Stars in Massive Clusters

    E-print Network

    C. J. Clarke

    2007-02-05

    We present models in which the photoevaporation of discs around young stars by an external ultraviolet source (as computed by Adams et al 2004) is coupled with the internal viscous evolution of the discs. These models are applied to the case of the Orion Nebula Cluster, where the presence of a strong ultraviolet field from the central OB stars, together with a detailed census of circumstellar discs and photoevaporative flows, is well established. In particular we investigate the constraints that are placed on the initial disc properties in the ONC by the twin requirement that most stars possess a disc on a scale of a few A.U., but that only a minority ($ 0.1 M_\\odot$). The ubiquity of discs on a small scale, on the other hand, mainly constrains the timespan over which the discs have been exposed to the ultraviolet field ($< 2 $Myr). We argue that the discs that are resolved by HST represent a population of discs in which self-gravity was important at the time that the dominant central OB star switched on, but that, according to our models, self-gravity is unlikely to be important in these discs at the present time. We discuss the implications of our results for the so-called proplyd lifetime problem.

  13. Gradient composite materials for artificial intervertebral discs.

    PubMed

    Migacz, Katarzyna; Ch?opek, Jan; Morawska-Chochó?, Anna; Ambroziak, Maciej

    2014-01-01

    Composites with the gradient of Young's modulus constitute a new group of biomimetic materials which affect the proper distribution of stresses between the implant and the bone. The aim of this article was to examine the mechanical properties of gradient materials based on carbon fibre-polysulfone composite, and to compare them to the properties of a natural intervertebral disc. Gradient properties were provided by different orientation or volume fraction of carbon fibres in particular layers of composites. The results obtained during in vitro tests displayed a good durability of the gradient materials put under long-term static load. However, the configuration based on a change in the volume fraction of the fibres seems more advantageous than the one based on a change of the fibres' orientation. The materials under study were designed to replace the intervertebral disc. The effect of Young's modulus of the material layers on the stress distribution between the tissue and the implant was analyzed and the biomimetic character of the gradient composites was stated. Unlike gradient materials, the pure polysulfone and the non-gradient composite resulted in the stress concentration in the region of nucleus pulposus, which is highly disadvantageous and does not occur in the stress distribution of natural intervertebral discs. PMID:25306938

  14. Accretion disc origin of the Earth's water.

    PubMed

    Vattuone, Luca; Smerieri, Marco; Savio, Letizia; Asaduzzaman, Abu Md; Muralidharan, Krishna; Drake, Michael J; Rocca, Mario

    2013-07-13

    Earth's water is conventionally believed to be delivered by comets or wet asteroids after the Earth formed. However, their elemental and isotopic properties are inconsistent with those of the Earth. It was thus proposed that water was introduced by adsorption onto grains in the accretion disc prior to planetary growth, with bonding energies so high as to be stable under high-temperature conditions. Here, we show both by laboratory experiments and numerical simulations that water adsorbs dissociatively on the olivine {100} surface at the temperature (approx. 500-1500 K) and water pressure (approx. 10?? bar) expected for the accretion disc, leaving an OH adlayer that is stable at least up to 900 K. This may result in the formation of many Earth oceans, provided that a viable mechanism to produce water from hydroxyl exists. This adsorption process must occur in all disc environments around young stars. The inevitable conclusion is that water should be prevalent on terrestrial planets in the habitable zone around other stars. PMID:23734050

  15. Effects of bone cement on intervertebral disc degeneration.

    PubMed

    Zhao, Hui; Ni, Cai-Fang; Huang, Jian; Zhao, Su-Ming; Gu, Wei-Wei; Jiang, Hao; Chen, Long; Tan, Tian-Si

    2014-04-01

    Percutaneous vertebroplasty (PVP) is popular for the treatment of intractable pain due to vertebral collapse from various lesions, intervertebral disk leakage of cement is a frequent complication. The aim of this study was to determine whether bone cement causes disc degeneration, and to evaluate the degree of intervertebral disc degeneration (IDD) according to the time period following cement injection, and the type and volume of cement injected. Sixteen dogs were randomly divided into two groups that were sacrificed at 12 or 24 weeks following cement injection. Five intervertebral discs in each dog were studied, including one control untreated disc and four discs randomly injected with polymethylmethacrylate (PMMA) or calcium phosphate cement (CPC) in two quantities. Radiographic and magnetic resonance imaging (MRI) studies were performed prior to animal sacrifice. T2-weighted mid-sagittal images of the discs were qualitatively analyzed for evidence of degeneration by calculating the MRI index, and all harvested discs were studied histopathologically. IDD was not evident in control discs. Univariate analysis revealed significant differences in the MRI index and the histological grade of disc degeneration in terms of the time period following cement injection, as well as the type and volume of cement injected. Result indicate that direct contact with PMMA and CPC can lead to IDD. However, IDD induced by PMMA was more severe than that induced by CPC. The extent of IDD was found to correlate with the time period post-cement injection and the volume of cement injected into the disc. PMMA and CPC may lead to intervertebral disc degeneration. Intervertebral disc degeneration induced by PMMA is more serious than that of CPC. The degree of intervertebral disc degeneration is correlative to the time after operation and the doses of bone cement. PMID:24669259

  16. Structural and Ultrastructural Analysis of the Cervical Discs of Young and Elderly Humans

    PubMed Central

    Fontes, Ricardo Braganca de Vasconcellos; Baptista, Josemberg Silva; Rabbani, Said Rahnamaye; Traynelis, Vincent C.; Liberti, Edson Aparecido

    2015-01-01

    Several studies describing the ultrastructure and extracellular matrix (ECM) of intervertebral discs (IVDs) involve animal models and specimens obtained from symptomatic individuals during surgery for degenerative disease or scoliosis, which may not necessarily correlate to changes secondary to normal aging in humans. These changes may also be segment-specific based on different load patterns throughout life. Our objective was to describe the ECM and collagen profile of cervical IVDs in young (G1 - <35 years) and elderly (G2 - >65 years) presumably-asymptomatic individuals. Thirty cervical discs per group were obtained during autopsies of presumably-asymptomatic individuals. IVDs were analyzed with MRI, a morphological grading scale, light microscopy, scanning electron microscopy (SEM) and immunohistochemistry (IHC) for collagen types I, II, III, IV, V, VI, IX and X. Macroscopic degenerative features such as loss of annulus-nucleus distinction and fissures were found in both groups and significantly more severe in G2 as expected. MRI could not detect all morphological changes when compared even with simple morphological inspection. The loose fibrocartilaginous G1 matrix was replaced by a denser ECM in G2 with predominantly cartilaginous characteristics, chondrocyte clusters and absent elastic fibers. SEM demonstrated persistence of an identifiable nucleus and Sharpey-type insertion of cervical annulus fibers even in highly-degenerated G2 specimens. All collagen types were detected in every disc sector except for collagen X, with the largest area stained by collagens II and IV. Collagen detection was significantly decreased in G2: although significant intradiscal differences were rare, changes may occur faster or earlier in the posterior annulus. These results demonstrate an extensive modification of the ECM with maintenance of basic ultrastructural features despite severe macroscopic degeneration. Collagen analysis supports there is not a “pathologic” collagen type and changes are generally similar throughout the disc. Understanding the collagen and ultrastructural substrate of degenerative changes in the human disc is an essential step in planning restorative therapies. PMID:26427056

  17. NAVY PRECISION OPTICAL INTERFEROMETER OBSERVATIONS OF THE EXOPLANET HOST {kappa} CORONAE BOREALIS AND THEIR IMPLICATIONS FOR THE STAR'S AND PLANET'S MASSES AND AGES

    SciTech Connect

    Baines, Ellyn K.; Armstrong, J. Thomas; Van Belle, Gerard T.

    2013-07-01

    We used the Navy Precision Optical Interferometer to measure the limb-darkened angular diameter of the exoplanet host star {kappa} CrB and obtained a value of 1.543 {+-} 0.009 mas. We calculated its physical radius (5.06 {+-} 0.04 R{sub Sun }) and used photometric measurements from the literature with our diameter to determine {kappa} CrB's effective temperature (4788 {+-} 17 K) and luminosity (12.13 {+-} 0.09 L{sub Sun }). We then placed the star on an Hertzsprung-Russell diagram to ascertain the star's age (3.42{sup +0.32}{sub -0.25} Gyr) and mass (1.47 {+-} 0.04 M{sub Sun }) using a metallicity of [Fe/H] = +0.15. With this mass, we calculated the system's mass function with the orbital elements from a variety of sources, which produced a range of planetary masses: m{sub p}sin i = 1.61-1.88 M{sub Jup}. We also updated the extent of the habitable zone for the system using our new temperature.

  18. The Application of Fiber-Reinforced Materials in Disc Repair

    PubMed Central

    Pei, Bao-Qing; Li, Hui; Zhu, Gang; Li, De-Yu; Fan, Yu-Bo; Wu, Shu-Qin

    2013-01-01

    The intervertebral disc degeneration and injury are the most common spinal diseases with tremendous financial and social implications. Regenerative therapies for disc repair are promising treatments. Fiber-reinforced materials (FRMs) are a kind of composites by embedding the fibers into the matrix materials. FRMs can maintain the original properties of the matrix and enhance the mechanical properties. By now, there are still some problems for disc repair such as the unsatisfied static strength and dynamic properties for disc implants. The application of FRMs may resolve these problems to some extent. In this review, six parts such as background of FRMs in tissue repair, the comparison of mechanical properties between natural disc and some typical FRMs, the repair standard and FRMs applications in disc repair, and the possible research directions for FRMs' in the future are stated. PMID:24383057

  19. Accretion disc viscosity: a limit on the anisotropy

    NASA Astrophysics Data System (ADS)

    Nixon, Chris

    2015-07-01

    Observations of warped discs can give insight into the nature of angular momentum transport in accretion discs. Only a few objects are known to show strong periodicity on long time-scales, but when such periodicity is present it is often attributed to precession of the accretion disc. The X-ray binary Hercules X-1/HZ Herculis (Her X-1) is one of the best examples of such periodicity and has been linked to disc precession since it was first observed. By using the current best-fitting models to Her X-1, which invoke precession driven by radiation warping, I place a constraint on the effective viscosities that act in a warped disc. These effective viscosities almost certainly arise due to turbulence induced by the magnetorotational instability. The constraints derived here are in agreement with analytical and numerical investigations into the nature of magnetohydrodynamic disc turbulence, but at odds with some recent global simulations.

  20. The Gaia-ESO Survey: New constraints on the Galactic disc velocity dispersion and its chemical dependencies

    E-print Network

    Guiglion, G; de Laverny, P; Kordopatis, G; Hill, V; Mikolaitis, Š; Minchev, I; Chiappini, C; Wyse, R F G; Gilmore, G; Randich, S; Feltzing, S; Bensby, T; Flaccomio, E; Koposov, S E; Pancino, E; Bayo, A; Costado, M T; Franciosini, E; Hourihane, A; Jofré, P; Lardo, C; Lewis, J; Lind, K; Magrini, L; Morbidelli, L; Sacco, G G; Ruchti, G; Worley, C C; Zaggia, S

    2015-01-01

    Understanding the history and the evolution of the Milky Way disc is one of the main goals of modern astrophysics. We study the velocity dispersion behaviour of Galactic disc stars as a function of the [Mg/Fe] ratio, which can be used as a proxy of relative age. This key relation is essential to constrain the formation mechanisms of the disc stellar populations as well as the cooling processes. We used the recommended parameters and chemical abundances of 7800 FGK Milky Way field stars from the second internal data release of the Gaia-ESO Survey. These stars were observed with the GIRAFFE spectrograph, and cover a large spatial volume (6+0.2dex. First, the velocity dispersion increases with [Mg/Fe] at all [Fe/H] ratios for the thin-disc stars, and then it decreases for the thick-disc at the highest [Mg/Fe] abundances. Similar trends are observed within the errors for the azimuthal velocity dispersion, while a continuous increase with [Mg/Fe] is observed for the vertical velocity dispersion. The velocity dispe...

  1. Dancing with the stars: formation of the Fomalhaut triple system and its effect on the debris discs

    NASA Astrophysics Data System (ADS)

    Shannon, Andrew; Clarke, Cathie; Wyatt, Mark

    2014-07-01

    Fomalhaut is a triple system, with all components widely separated (˜105 au). Such widely separated binaries are thought to form during cluster dissolution, but that process is unlikely to form such a triple system. We explore an alternative scenario, where A and C form as a tighter binary from a single molecular cloud core (with semimajor axis ˜104 au), and B is captured during cluster dispersal. We use N-body simulations augmented with the Galactic tidal forces to show that such a system naturally evolves into a Fomalhaut-like system in about half of cases, on a time-scale compatible with the age of Fomalhaut. From initial non-interacting orbits, Galactic tides drive cycles in B's eccentricity that lead to a close encounter with C. After several close encounters, typically lasting tens of millions of years, one of the stars is ejected. The Fomalhaut-like case with both components at large separations is almost invariably a precursor to the ejection of one component, most commonly Fomalhaut C. By including circumstellar debris in a subset of the simulations, we also show that such an evolution usually does not disrupt the coherently eccentric debris disc around Fomalhaut A, and in some cases can even produce such a disc. We also find that the final eccentricity of the disc around A and the disc around C are correlated, which may indicate that the dynamics of the three stars stirred C's disc, explaining its unusual brightness.

  2. Automated determination of cup-to-disc ratio for classification of glaucomatous and normal eyes on stereo retinal fundus images

    NASA Astrophysics Data System (ADS)

    Muramatsu, Chisako; Nakagawa, Toshiaki; Sawada, Akira; Hatanaka, Yuji; Yamamoto, Tetsuya; Fujita, Hiroshi

    2011-09-01

    Early diagnosis of glaucoma, which is the second leading cause of blindness in the world, can halt or slow the progression of the disease. We propose an automated method for analyzing the optic disc and measuring the cup-to-disc ratio (CDR) on stereo retinal fundus images to improve ophthalmologists' diagnostic efficiency and potentially reduce the variation on the CDR measurement. The method was developed using 80 retinal fundus image pairs, including 25 glaucomatous, and 55 nonglaucomatous eyes, obtained at our institution. A disc region was segmented using the active contour method with the brightness and edge information. The segmentation of a cup region was performed using a depth map of the optic disc, which was reconstructed on the basis of the stereo disparity. The CDRs were measured and compared with those determined using the manual segmentation results by an expert ophthalmologist. The method was applied to a new database which consisted of 98 stereo image pairs including 60 and 30 pairs with and without signs of glaucoma, respectively. Using the CDRs, an area under the receiver operating characteristic curve of 0.90 was obtained for classification of the glaucomatous and nonglaucomatous eyes. The result indicates potential usefulness of the automated determination of CDRs for the diagnosis of glaucoma.

  3. Audiovisual Bounce-Inducing Effect: Attention Alone Does Not Explain Why the Discs Are Bouncing

    ERIC Educational Resources Information Center

    Grassi, Massimo; Casco, Clara

    2009-01-01

    Two discs moving from opposite points in space, overlapping and stopping at the other disc's starting point, can be seen as either bouncing or streaming through each other. With silent displays, observers report the discs as streaming, whereas if a sound is played when the discs touch each other, observers report the discs as bouncing. The origin…

  4. Molecules in Protoplanetary HAEBE discs as seen with Herschel.

    NASA Astrophysics Data System (ADS)

    Meeus, G.

    2011-05-01

    The discovery of planets around other stars has revealed that planet formation is ubiquitous. However, the mechanisms determining planet formation are not (yet) well-understood. Primordial protoplanetary discs consist 99% out of gas, and only 1% out of dust. With time, those discs are believed to evolve from a flaring geometry into a flat geometry, as the initially small dust grains grow to larger sizes and settle towards the mid-plane. In the mean time, the gas will disperse, until so little is left that giant planets no longer can form. It is thus important to understand the chemical composition of the disc and the influence of the gas heating/cooling processes on the disc structure, and finally how gas gets dispersed as a pieces of the puzzle of planet formation. In this contribution, we study the protoplanetary discs around Herbig Ae/Be stars, young objects of intermediate mass, in the context of gas chemistry. We present Herschel PACS spectroscopic observations for a sample that was obtained within the GASPS (Gas in Protoplanetary Systems) Open Time Key Project, concentrating on the detection and characterisation of emission lines of the molecules H20, CO and CH+ (besides [OI] and [CII]), tracing the disc between 5 and 500 AU. We look for correlations between the observed line fluxes and stellar properties such as effective temperature, Halpha emission, accretion rates and UV flux, as well as the disc properties: degree of flaring, presence and strength of PAH emission and disc mass. We will present a few cases to show how simultaneous modeling (using the thermo-chemical disc code ProDiMo) of the atomic fine structure lines and both Space Telescope and ground-based molecular lines can constrain the disc gas mass, once the disc structure is derived (here with the radiative transfer code MCFost). Finally, we compare our gas line observations with those of young debris disc stars, for which the HAEBE stars are thought to be progenitors.

  5. New Brown Dwarf Discs in Upper Scorpius Observed with WISE

    NASA Technical Reports Server (NTRS)

    Dawson, P.; Scholz, A.; Ray, T. P.; Natta, A.; Marsh, K. A.; Padgett, D.; Ressler, M. E.

    2013-01-01

    We present a census of the disc population for UKIDSS selected brown dwarfs in the 5-10 Myr old Upper Scorpius OB association. For 116 objects originally identified in UKIDSS, the majority of them not studied in previous publications, we obtain photometry from the Wide-Field Infrared Survey Explorer data base. The resulting colour magnitude and colour colour plots clearly show two separate populations of objects, interpreted as brown dwarfs with discs (class II) and without discs (class III). We identify 27 class II brown dwarfs, 14 of them not previously known. This disc fraction (27 out of 116, or 23%) among brown dwarfs was found to be similar to results for K/M stars in Upper Scorpius, suggesting that the lifetimes of discs are independent of the mass of the central object for low-mass stars and brown dwarfs. 5 out of 27 discs (19 per cent) lack excess at 3.4 and 4.6 microns and are potential transition discs (i.e. are in transition from class II to class III). The transition disc fraction is comparable to low-mass stars.We estimate that the time-scale for a typical transition from class II to class III is less than 0.4 Myr for brown dwarfs. These results suggest that the evolution of brown dwarf discs mirrors the behaviour of discs around low-mass stars, with disc lifetimes of the order of 5 10 Myr and a disc clearing time-scale significantly shorter than 1 Myr.

  6. Gravitational instability in protostellar discs at low metallicities

    NASA Astrophysics Data System (ADS)

    Tanaka, Kei E. I.; Omukai, Kazuyuki

    2014-04-01

    Fragmentation of protostellar discs controls the growth of protostars and plays a key role in determining the final mass of newborn stars. In this paper, we investigate the structure and gravitational stability of the protostellar discs in the full metallicity range between zero and the solar value. Using the mass-accretion rates evaluated from the thermal evolution in the preceding collapse phase of the pre-stellar cores, we calculate disc structures and their evolution in the framework of the standard steady discs. Overall, with higher metallicity, more efficient cooling results in the lower accretion rate and lower temperature inside the disc: at zero metallicity, the accretion rate is ˜10-3 M? yr-1 and the disc temperature is ˜1000 K, while at solar metallicity, ˜10-6 M? yr-1 and ˜10 K. Despite the large difference in these values, the zero- and solar-metallicity discs have similar stability properties: the Toomre parameter for the gravitational stability, which can be written using the ratio of temperatures in the disc and in the envelope as QT ˜ (Tdisc/Tenv)3/2, is ? 1, i.e. marginally stable. At intermediate metallicities of 10-5 to 10-3 Z?, however, the discs are found to be strongly unstable with QT ˜ 0.1-1 since dust cooling, which is effective only in the discs due to their high density ( ? 1010 cm- 3), makes the temperature in the discs lower than that in the envelopes. This indicates that masses of the individual stars formed as a result of the protostellar disc fragmentation can be significantly smaller than their parent core in this metallicity range. The typical stellar mass in this case would be a few M?, which is consistent with the observationally suggested mass-scale of extremely metal-poor stars.

  7. Nanostructure changes in the intervertebral discs after experimental laser irradiation.

    PubMed

    Byval'tsev, V A; Panasenkov, S Yu; Belykh, E G; Ivanov, N A; Tsyganov, P Yu; Nikiforov, S B; Sorokovikov, V A; Grigor'ev, E G; Kolesnikov, S I

    2015-02-01

    Laser-induced changes in the intervertebral discs were studied by the method of atomic force microscopy. Alteration of the proximal caudal intervertebral discs was modeled in rats: puncture and exposure to diode laser (2, 3, or 5 W) in constant or pulse regimens or only puncture (control). Nanostructure of disc surface was estimated by surface skewness, root mean square and average roughness, and coefficient of kurtosis. Maximum positive effect and signs of regenerative changes in the surface microstructure of the intervertebral discs were found after exposure to laser (2-3 W) in constant or pulse regimens. PMID:25708335

  8. 21 CFR 866.1620 - Antimicrobial susceptibility test disc.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Diagnostic Devices § 866.1620 Antimicrobial susceptibility test disc. (a)...

  9. Angular momentum of disc galaxies with a lognormal density distribution

    NASA Astrophysics Data System (ADS)

    Marr, John H.

    2015-10-01

    By postulating that the majority of the mass and angular momentum of a disc galaxy is confined to the disc with a lognormal surface density distribution, and that galactic discs are substantially, if not fully, self-gravitating, it may be shown that the resultant rotation curves (RCs) display a good overall fit to observational data for a wide range of galaxy types. With this hypothesis, the total angular momentum J, and total energy |E| of 38 disc galaxies was computed and plotted against the derived disc masses, with best fit slopes for J of 1.683 ± 0.018 and |E| of 1.643 ± 0.038, and a universal disc spin parameter ? = 0.423 ± 0.014. Using the disc parameters Vmax and Rmax as surrogates for the virial velocity and radius, a virial mass estimator M_{disc} ? R_{max} V_{max}^2 was generated, with a log-log slope of 1.024 ± 0.014 for the 38 galaxies, and a proportionality constant ?* = 1.47 ± 0.20 × 105 M?kpc- 1 km- 2 s2. This relationship has less scatter than M?(Vrot)?, and may provide an alternative to the Tully-Fisher relation in determining virial disc masses.

  10. MECHANICAL DESIGN CRITERIA FOR INTERVERTEBRAL DISC TISSUE ENGINEERING

    PubMed Central

    Nerurkar, Nandan L.; Elliott, Dawn M.; Mauck, Robert L.

    2009-01-01

    Due to the inability of current clinical practices to restore function to degenerated intervertebral discs, the arena of disc tissue engineering has received substantial attention in recent years. Despite tremendous growth and progress in this field, translation to clinical implementation has been hindered by a lack of well-defined functional benchmarks. Because successful replacement of the disc is contingent upon replication of some or all of its complex mechanical behaviour, it is critically important that disc mechanics be well characterized in order to establish discrete functional goals for tissue engineering. In this review, the key functional signatures of the intervertebral disc are discussed and used to propose a series of native tissue benchmarks to guide the development of engineered replacement tissues. These benchmarks include measures of mechanical function under tensile, compressive and shear deformations for the disc and its substructures. In some cases, important functional measures are identified that have yet to be measured in the native tissue. Ultimately, native tissue benchmark values are compared to measurements that have been made on engineered disc tissues, identifying measures where functional equivalence was achieved, and others where there remain opportunities for advancement. Several excellent reviews exist regarding disc composition and structure, as well as recent tissue engineering strategies; therefore this review will remain focused on the functional aspects of disc tissue engineering. PMID:20080239

  11. Does the stellar disc flattening depend on the galaxy type?

    NASA Astrophysics Data System (ADS)

    Mosenkov, A. V.; Sotnikova, N. Ya.; Reshetnikov, V. P.; Bizyaev, D. V.; Kautsch, S. J.

    2015-08-01

    We analyse the dependence of the stellar disc flatness on the galaxy morphological type using 2D decomposition of galaxies from the reliable subsample of the Edge-on Galaxies in SDSS catalogue. Combining these data with the retrieved models of the edge-on galaxies from the Two Micron All Sky Survey and the Spitzer Survey of Stellar Structure in Galaxies catalogue, we make the following conclusions. The disc relative thickness z0/h in the near- and mid-infrared passbands correlates weakly with morphological type and does not correlate with the bulge-to-total luminosity ratio B/T in all studied bands. Applying a 1D photometric profile analysis overestimates the disc thickness in galaxies with large bulges making an illusion of the relationship between the disc flattening and the ratio B/T. In our sample, the early-type disc galaxies (S0/a) have both flat and `puffed' discs. The early spirals and intermediate-type galaxies have a large scatter of the disc flatness, which can be caused by the presence of a bar: barred galaxies have thicker stellar discs, on average. On the other hand, the late-type spirals are mostly thin galaxies, whereas irregular galaxies have puffed stellar discs.

  12. Analysis of rabbit intervertebral disc physiology based on water metabolism. II. Changes in normal intervertebral discs under axial vibratory load

    SciTech Connect

    Hirano, N.; Tsuji, H.; Ohshima, H.; Kitano, S.; Itoh, T.; Sano, A.

    1988-11-01

    Metabolic changes induced by axial vibratory load to the spine were investigated based on water metabolism in normal intervertebral discs of rabbits with or without pentobarbital anesthesia. Tritiated water concentration in the intervertebral discs of unanesthetized rabbits was reduced remarkably by axial vibration for 30 minutes using the vibration machine developed for this study. Repeated vibratory load for 18 and 42 hours duration showed the recovery of /sup 3/H/sub 2/O concentration of the intervertebral disc without anesthesia. Computer simulation suggested a reduction of blood flow surrounding the intervertebral disc following the vibration stress. However, no reduction of the /sup 3/H/sub 2/O concentration in the intervertebral disc was noted under anesthesia. Emotional stress cannot be excluded as a factor in water metabolism in the intervertebral disc.

  13. Immunohistochemical expression of types I and III collagen antibodies in the temporomandibular joint disc of human foetuses

    PubMed Central

    de Moraes, L.O.C.; Lodi, F.R.; Gomes, T.S.; Marques, S.R.; Oshima, C.T.F.; Lancellotti, C.L.P.; Rodríguez-Vázquez, J.F.; Mérida-Velasco, J.R.; Alonso, L.G.

    2011-01-01

    The objective was to study the morphology of the articular disc and analyse the immunohistochemical expression of types I and III collagen markers in the temporomandibular joint (TMJ) disc of human foetuses of different gestational ages. Twenty TMJ from human foetuses supplied by Universidade Federal de Uberaba with gestational ages from 17 to 24 weeks were studied. The gestational age of the foetuses was determined by measuring the crown-rump (CR) length. Macroscopically, the foetuses were fixed in 10% formalin solution and dissected by removing the skin and subcutaneous tissue and exposing the deep structures. Immunohistochemical markers of type I and III were used to characterize the existence of collagen fibres. Analysis of the immunohistochemical markers of types I and III collagen revealed the presence of heterotypical fibril networks. PMID:22073371

  14. ISASS Policy Statement - Cervical Artificial Disc.

    PubMed

    Coric, Domagoj

    2014-01-01

    Morgan Lorio, MD, FACS, Chair, ISASS Task Force on Coding & Reimbursement The ISASS Task Force reached out to Domagoj Coric, MD to provide a timely summation on cervical disc arthroplasty given his special interest and recent IASP championship of this innovative technology to insure enhanced spine patient access. The ISASS Task Force is pleased with this step towards published ISASS societal policy and applauds Dr. Coric's effort; if ISASS is to continue to succeed we must continually harness the voluntary talents and energies of our members with gratitude. PMID:25694944

  15. Correlation between Voronoi volumes in disc packings

    E-print Network

    Song-Chuan Zhao; Stacy Sidle; Harry L. Swinney; Matthias Schröter

    2011-12-19

    We measure the two-point correlation of free Voronoi volumes in binary disc packings, where the packing fraction $\\phi_{\\rm avg}$ ranges from 0.8175 to 0.8380. We observe short-ranged correlations over the whole range of $\\phi_{\\rm avg}$ and anti-correlations for $\\phi_{\\rm avg}>0.8277$. The spatial extent of the anti-correlation increases with $\\phi_{\\rm avg}$ while the position of the maximum of the anti-correlation and the extent of the positive correlation shrink with $\\phi_{\\rm avg}$. We conjecture that the onset of anti-correlation corresponds to dilatancy onset in this system.

  16. ISASS Policy Statement – Lumbar Artificial Disc

    PubMed Central

    Garcia, Rolando

    2015-01-01

    Purpose The primary goal of this Policy Statement is to educate patients, physicians, medical providers, reviewers, adjustors, case managers, insurers, and all others involved or affected by insurance coverage decisions regarding lumbar disc replacement surgery. Procedures This Policy Statement was developed by a panel of physicians selected by the Board of Directors of ISASS for their expertise and experience with lumbar TDR. The panel's recommendation was entirely based on the best evidence-based scientific research available regarding the safety and effectiveness of lumbar TDR. PMID:25785243

  17. 75 FR 54345 - Determination of Regulatory Review Period for Purposes of Patent Extension; BRYAN CERVICAL DISC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-07

    ...marketing the medical device BRYAN CERVICAL DISC SYSTEM. BRYAN CERVICAL DISC SYSTEM is indicated in...intractable radiculopathy and/or myelopathy. Subsequent to this approval...restoration application for BRYAN CERVICAL DISC SYSTEM (U.S....

  18. DISC1 & GSK3? modulate PDE4 activity: functional integration of psychiatric associated signalling pathways 

    E-print Network

    Carlyle, Becky Catherine

    2010-01-01

    Following the discovery of the DISC1 gene in 2000, subsequent research has led to DISC1 becoming one of the most promising candidate genes for psychiatric disorders. Acting as a scaffold protein, DISC1 has a large number ...

  19. Dixdc1 Is a Critical Regulator of DISC1 and Embryonic Cortical Development

    E-print Network

    Singh, Karun K.

    The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important role in brain development; however, it is unclear how DISC1 is regulated during cortical development. Here, we report that DISC1 is ...

  20. Dynamic Compression Effects on Intervertebral Disc Mechanics and Biology

    PubMed Central

    Korecki, Casey L.; MacLean, Jeffrey J.; Iatridis, James C.

    2008-01-01

    Study Design A bovine intervertebral disc organ culture model was used to study the effect of dynamic compression magnitude on mechanical behavior and measurement of biosynthesis rate, cell viability, and mRNA expression. Objective The objective of this study was to examine the effect of loading magnitude on intervertebral disc mechanics and biology in an organ culture model. Summary of Background Data The in vivo and cell culture response of intervertebral disc cells to dynamic mechanical loading provides evidence the disc responds in a magnitude dependant manner. However, the ability to link mechanical behavior of the disc with biologic phenomena has been limited. A large animal organ culture system facilitates measurements of tissue mechanics and biologic response parameters on the same sample allowing a broader understanding of disc mechanobiology. Methods Bovine caudal intervertebral discs were placed in organ culture for 6 days and assigned to a static control or 1 of 2 dynamic compression loading protocols (0.2–1 MPa or 0.2–2.5 MPa) at 1 Hz for 1 hour for 5 days. Disc structure was assessed with measurements of dynamic modulus, creep, height loss, water content, and proteoglycan loss to the culture medium. Cellular responses were assessed through changes in cell viability, metabolism, and qRT-PCR analyses. Results Increasing magnitudes of compression increased disc modulus and creep; however, all mechanical parameters recovered each day. In the anulus, significant increases in gene expression for collagen I and a trend of increasing sulfate incorporation were observed. In the nucleus, increasing gene expression for collagen I and MMP3 was observed between magnitudes and between static controls and the lowest magnitude of loading. Conclusion Results support the hypothesis that biologic remodeling precedes damage to the intervertebral disc structure, that compression is a healthy loading condition for the disc, and further support the link between applied loading and biologic remodeling. PMID:18520935

  1. K2 and MAXI observations of Sco X-1 - evidence for disc precession?

    NASA Astrophysics Data System (ADS)

    Hakala, Pasi; Ramsay, Gavin; Barclay, Thomas; Charles, Phil

    2015-10-01

    Sco X-1 is the archetypal low-mass X-ray binary and the brightest persistent extrasolar X-ray source in the sky. It was included in the K2 Campaign 2 field and was observed continuously for 71 d with 1 min time resolution. In this Letter, we report these results and underline the potential of K2 for similar observations of other accreting compact binaries. We reconfirm that Sco X-1 shows a bimodal distribution of optical `high' and `low' states and rapid transitions between them on time-scales less than 3 h (or 0.15 orbits). We also find evidence that this behaviour has a typical systemic time-scale of 4.8 d, which we interpret as a possible disc precession period in the system. Finally, we confirm the complex optical versus X-ray correlation/anticorrelation behaviour for `high' and `low' optical states, respectively.

  2. Physico-chemical characteristics of ZnO nanoparticles-based discs and toxic effect on human cervical cancer HeLa cells

    NASA Astrophysics Data System (ADS)

    Sirelkhatim, Amna; Mahmud, Shahrom; Seeni, Azman; Kaus, Noor Haida Mohd.; Sendi, Rabab

    2014-10-01

    In this study, we investigated physico-chemical properties of zinc oxide nanoparticles (ZnO NPs)-based discs and their toxicity on human cervical cancer HeLa cell lines. ZnO NPs (80 nm) were produced by the conventional ceramic processing method. FESEM analysis indicated dominant structure of nanorods with dimensions 100-500 nm in length, and 20-100 nm in diameter. The high content of ZnO nanorods in the discs probably played significant role in toxicity towards HeLa cells. Structural defects (oxygen vacancies and zinc/oxygen interstitials) were revealed by PL spectra peaks at 370-376 nm and 519-533 nm for the ZnO discs. The structural, optical and electrical properties of prepared sample have influenced the toxicological effects of ZnO discs towards HeLa cell lines via the generation of reactive oxygen species (ROS), internalization, membrane damage, and eventually cell death. The larger surface to volume area of the ZnO nanorods, combined with defects, stimulated enhanced toxicity via ROS generation hydrogen peroxide, hydroxyl radicals, and superoxide anion. The preliminary results confirmed the ZnO-disc toxicity on HeLa cells was significantly associated with the unique physicochemical properties of ZnO NPs and to our knowledge, this is the first cellular study for treatment of HeLa cells with ZnO discs made from 80 nm ZnO particles.

  3. The evolution of the disc variability along the hard state of the black hole transient GX 339-4

    NASA Astrophysics Data System (ADS)

    De Marco, B.; Ponti, G.; Muñoz-Darias, T.; Nandra, K.

    2015-12-01

    We report on the analysis of hard-state power spectral density function (PSD) of GX 339-4 down to the soft X-ray band, where the disc significantly contributes to the total emission. At any luminosity probed, the disc in the hard state is intrinsically more variable than in the soft state. However, the fast decrease of disc variability as a function of luminosity, combined with the increase of disc intensity, causes a net drop of fractional variability at high luminosities and low energies, which reminds the well-known behaviour of disc-dominated energy bands in the soft state. The peak frequency of the high-frequency Lorentzian (likely corresponding to the high-frequency break seen in active galactic nuclei, AGN) scales with luminosity, but we do not find evidence for a linear scaling. In addition, we observe that this characteristic frequency is energy dependent. We find that the normalization of the PSD at the peak of the high-frequency Lorentzian decreases with luminosity at all energies, though in the soft band this trend is steeper. Together with the frequency shift, this yields quasi-constant high-frequency (5-20 Hz) fractional rms at high energies, with less than 10 per cent scatter. This reinforces previous claims suggesting that the high-frequency PSD solely scales with black hole mass. On the other hand, this constancy breaks down in the soft band (where the scatter increases to ˜30 per cent). This is a consequence of the additional contribution from the disc component, and resembles the behaviour of optical variability in AGN.

  4. Accretion Disc Time Lag Distributions: Applying CREAM to Simulated AGN Light Curves

    E-print Network

    Starkey, David; Villforth, Carolin

    2015-01-01

    Active Galactic Nuclei (AGN) vary in their brightness across all wavelengths. Moreover, longer wavelength ultraviolet - optical continuum light curves appear to be delayed with respect to shorter wavelength light curves. A simple way to model these delays is by assuming thermal reprocessing of a variable point source (a lamp post) by a blackbody accretion disc. We introduce a new method, CREAM (\\textbf{C}ontinuum \\textbf{RE}processed \\textbf{A}GN \\textbf{M}arkov Chain Monte Carlo), that models continuum variations using this lamp post model. The disc light curves lag the lamp post emission with a time delay distribution sensitive to the disc temperature-radius profile and inclination. We test CREAM's ability to recover both inclination and product of black hole mass and accretion rate $\\mmdot$, and show that the code is also able to infer the shape of the driving light curve. CREAM is applied to synthetic light curves expected from 1000 second exposures of a 17th magnitude AGN with a 2m telescope in Sloan g a...

  5. HERO - A 3D general relativistic radiative post-processor for accretion discs around black holes

    NASA Astrophysics Data System (ADS)

    Zhu, Yucong; Narayan, Ramesh; Sadowski, Aleksander; Psaltis, Dimitrios

    2015-08-01

    HERO (Hybrid Evaluator for Radiative Objects) is a 3D general relativistic radiative transfer code which has been tailored to the problem of analysing radiation from simulations of relativistic accretion discs around black holes. HERO is designed to be used as a post-processor. Given some fixed fluid structure for the disc (i.e. density and velocity as a function of position from a hydrodynamic or magnetohydrodynamic simulation), the code obtains a self-consistent solution for the radiation field and for the gas temperatures using the condition of radiative equilibrium. The novel aspect of HERO is that it combines two techniques: (1) a short-characteristics (SC) solver that quickly converges to a self-consistent disc temperature and radiation field, with (2) a long-characteristics (LC) solver that provides a more accurate solution for the radiation near the photosphere and in the optically thin regions. By combining these two techniques, we gain both the computational speed of SC and the high accuracy of LC. We present tests of HERO on a range of 1D, 2D, and 3D problems in flat space and show that the results agree well with both analytical and benchmark solutions. We also test the ability of the code to handle relativistic problems in curved space. Finally, we discuss the important topic of ray defects, a major limitation of the SC method, and describe our strategy for minimizing the induced error.

  6. A differentially rotating disc in a high-mass protostellar system

    E-print Network

    Pestalozzi, M; Conway, J

    2009-01-01

    A strong signature of a circumstellar disc around a high-mass protostar has been inferred from high resolution methanol maser observations in NGC7538-IRS1 N. This interpretation has however been challenged with a bipolar outflow proposed as an alternative explanation. We compare the two proposed scenarios for best consistency with the observations. Using a newly developed formalism we model the optical depth of the maser emission at each observed point in the map and LOS velocity for the two scenarios. We find that if the emission is symmetric around a central peak in both space and LOS velocity then it has to arise from an edge-on disc in sufficiently fast differential rotation. Disc models successfully fit ~100 independent measurement points in position-velocity space with 4 free parameters to an overall accuracy of 3-4%. Solutions for Keplerian rotation require a central mass of at least 4 solar masses. Close to best-fitting models are obtained if Keplerian motion is assumed around a central mass equaling ...

  7. The VAMPIRES instrument: imaging the innermost regions of protoplanetary discs with polarimetric interferometry

    NASA Astrophysics Data System (ADS)

    Norris, Barnaby; Schworer, Guillaume; Tuthill, Peter; Jovanovic, Nemanja; Guyon, Olivier; Stewart, Paul; Martinache, Frantz

    2015-03-01

    Direct imaging of protoplanetary discs promises to provide key insight into the complex sequence of processes by which planets are formed. However, imaging the innermost region of such discs (a zone critical to planet formation) is challenging for traditional observational techniques (such as near-IR imaging and coronagraphy) due to the relatively long wavelengths involved and the area occulted by the coronagraphic mask. Here, we introduce a new instrument - Visible Aperture-Masking Polarimetric Interferometer for Resolving Exoplanetary Signatures (VAMPIRES) - which combines non-redundant aperture-masking interferometry with differential polarimetry to directly image this previously inaccessible innermost region. By using the polarization of light scattered by dust in the disc to provide precise differential calibration of interferometric visibilities and closure phases, VAMPIRES allows direct imaging at and beyond the telescope diffraction limit. Integrated into the SCExAO (Subaru Coronagraphic Extreme Adaptive Optics) system at the Subaru telescope, VAMPIRES operates at visible wavelengths (where polarization is high) while allowing simultaneous infrared observations conducted by HICIAO. Here, we describe the instrumental design and unique observing technique and present the results of the first on-sky commissioning observations, validating the excellent visibility and closure-phase precision which are then used to project expected science performance metrics.

  8. En-face optical coherence tomography in the diagnosis and management of age-related macular degeneration and polypoidal choroidal vasculopathy

    PubMed Central

    Lau, Tiffany; Wong, Ian Y; Iu, Lawrence; Chhablani, Jay; Yong, Tao; Hideki, Koizumi; Lee, Jacky; Wong, Raymond

    2015-01-01

    Optical coherence tomography (OCT) is a noninvasive imaging modality providing high-resolution images of the central retina that has completely transformed the field of ophthalmology. While traditional OCT has produced longitudinal cross-sectional images, advancements in data processing have led to the development of en-face OCT, which produces transverse images of retinal and choroidal layers at any specified depth. This offers additional benefit on top of longitudinal cross-sections because it provides an extensive overview of pathological structures in a single image. The aim of this review was to discuss the utility of en-face OCT in the diagnosis and management of age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV). En-face imaging of the inner segment/outer segment junction of retinal photoreceptors has been shown to be a useful indicator of visual acuity and a predictor of the extent of progression of geographic atrophy. En-face OCT has also enabled high-resolution analysis and quantification of pathological structures such as reticular pseudodrusen (RPD) and choroidal neovascularization, which have the potential to become useful markers for disease monitoring. En-face Doppler OCT enables subtle changes in the choroidal vasculature to be detected in eyes with RPD and AMD, which has significantly advanced our understanding of their pathogenesis. En-face Doppler OCT has also been shown to be useful for detecting the polypoid lesions and branching vascular networks diagnostic of PCV. It may therefore serve as a noninvasive alternative to fluorescein and indocyanine green angiography for the diagnosis of PCV and other forms of the exudative macular disease. PMID:26139796

  9. Diocotron Modes in Nonneutral Disc Plasmas.

    NASA Astrophysics Data System (ADS)

    Quinn, J. C.; Dubin, D. H. E.

    2006-10-01

    We study the E xB dynamics of a thin disc of charge confined in a cylindrical Penning trap with wall radius Rw. The axial extent (thickness) of the disc is assumed to be negligible. We show that, as in other similar cases, monotonic density profiles are stable to small perturbations. We then consider the specific density profile that is a uniformly charged spheroid of radius R projected onto a plane, because for R Rw it has the special property of rotating without shear. An eigenvalue equation for a density perturbation can be obtained by linearizing the equations of motion and using a Green's function. We find an analytic expression for a special class of eigenmodes, which are the diocotron modes, and the corresponding eigenfrequencies. These expressions are compared to the results of a numerical computation which was done by discretizing the eigenvalue equation. These results are also compared to the 2d limit of the Dubin theory of electrostatic modes in a spheroidal plasma. D.H.E. Dubin, Phys. Rev. Lett. 66, 2076 (1991).

  10. Decimetre dust aggregates in protoplanetary discs

    E-print Network

    Teiser, Jens; 10.1051/0004-6361/200912027

    2011-01-01

    The growth of planetesimals is an essential step in planet formation. Decimetre-size dust agglomerates mark a transition point in this growth process. In laboratory experiments we simulated the formation, evolution, and properties of decimetre-scale dusty bodies in protoplanetary discs. Small sub-mm size dust aggregates consisting of micron-size SiO$_2$ particles randomly interacted with dust targets of varying initial conditions in a continuous sequence of independent collisions. Impact velocities were 7.7 m/s on average and in the range expected for collisions with decimetre bodies in protoplanetary discs. The targets all evolved by forming dust \\emph{crusts} with up to several cm thickness and a unique filling factor of 31% $\\pm$3%. A part of the projectiles sticks directly. In addition, some projectile fragments slowly return to the target by gravity. All initially porous parts of the surface, i.e. built from the slowly returning fragments, are compacted and firmly attached to the underlying dust layers b...

  11. Pressuredriven outflow and magnetocentrifugal wind from a dynamo active disc

    E-print Network

    Brandenburg, Axel

    a numerical model of an accretion disc with mean­field dynamo action that develops pressure­driven collimated is collimated and confined by the azimuthal magnetic field that is produced by the dynamo in the disc and collimating it into a jet in young stellar objects and active galactic nuclei; see K¨onigl & Pudritz (1999

  12. Tissue Engineering a Biological Repair Strategy for Lumbar Disc Herniation

    PubMed Central

    O'Connell, Grace D.; Leach, J. Kent; Klineberg, Eric O.

    2015-01-01

    Abstract The intervertebral disc is a critical part of the intersegmental soft tissue of the spinal column, providing flexibility and mobility, while absorbing large complex loads. Spinal disease, including disc herniation and degeneration, may be a significant contributor to low back pain. Clinically, disc herniations are treated with both nonoperative and operative methods. Operative treatment for disc herniation includes removal of the herniated material when neural compression occurs. While this strategy may have short-term advantages over nonoperative methods, the remaining disc material is not addressed and surgery for mild degeneration may have limited long-term advantage over nonoperative methods. Furthermore, disc herniation and surgery significantly alter the mechanical function of the disc joint, which may contribute to progression of degeneration in surrounding tissues. We reviewed recent advances in tissue engineering and regenerative medicine strategies that may have a significant impact on disc herniation repair. Our review on tissue engineering strategies focuses on cell-based and inductive methods, each commonly combined with material-based approaches. An ideal clinically relevant biological repair strategy will significantly reduce pain and repair and restore flexibility and motion of the spine. PMID:26634189

  13. Can giant planets form by gravitational fragmentation of discs?.

    NASA Astrophysics Data System (ADS)

    Stamatellos, D.; Whitworth, A. P.

    2008-03-01

    Context: Gravitational fragmentation has been proposed as a mechanism for the formation of giant planets in close orbits around solar-type stars. However, it is debatable whether this mechanism can function in the inner regions (R? 40 AU) of real discs. Aims: We investigate the thermodynamics of the inner regions of discs and their propensity to fragment. Methods: We use a newly developed method for treating the energy equation and the equation of state, which accounts for radiative transfer effects in SPH simulations of circumstellar discs. The different chemical and internal states of hydrogen and the properties of dust at different densities and temperatures (ice coated dust grains at low temperatures, ice melting, dust sublimation) are all taken into account by the new method. Results: We present radiative hydrodynamic simulations of the inner regions of massive circumstellar discs and examine two cases: (i) a disc irradiated by a cool background radiation field (T_BGR˜ 10 K) and (ii) a disc heated by radiation from its central star (T_BGR˜ 1200~K[R/AU]-1). In neither case does the disc fragment: in the former because it cannot cool fast enough and in the latter because it is not gravitationally unstable. Our results (a) corroborate previous numerical results using different treatments for the hydrodynamics and the radiative transfer, and (b) confirm our own earlier analytic predictions. Conclusions: Disc fragmentation is unlikely to be able to produce giant planets around solar-type stars at radii ?40 AU.

  14. Jet and disc luminosities in tidal disruption events

    NASA Astrophysics Data System (ADS)

    Piran, Tsvi; S?dowski, Aleksander; Tchekhovskoy, Alexander

    2015-10-01

    Tidal disruption events (TDEs) explore the whole range of accretion rates and configurations. A challenging question is what the corresponding light curves of these events are. We explore numerically the disc luminosity and the conditions within the inner region of the disc using a fully general relativistic slim disc model. Those conditions determine the magnitude of the magnetic field that engulfs the black hole and this, in turn, determines the Blandford-Znajek jet power. We estimate this power in two different ways and show that they are self-consistent. We find, as expected earlier from analytic arguments , that neither the disc luminosity nor the jet power follows the accretion rate throughout the disruption event. The disc luminosity varies only logarithmically with the accretion rate at super-Eddington luminosities. The jet power follows initially the accretion rate but remains constant after the transition from super- to sub-Eddington. At lower accretion rates at the end of the magnetically arrested disc (MAD) phase, the disc becomes thin and the jet may stop altogether. These new estimates of the jet power and disc luminosity that do not simply follow the mass fallback rate should be taken into account when searching for TDEs and analysing light curves of TDE candidates. Identification of some of the above-mentioned transitions may enable us to estimate better TDE parameters.

  15. The turbulent viscosity in accretion discs ULF TORKELSSON

    E-print Network

    Brandenburg, Axel

    The turbulent viscosity in accretion discs ULF TORKELSSON Sterrekundig Instituut, Postbus 80000 tur­ bulence. The turbulence is considered to be a likely source for viscosity in accretion discs. Re viscosity. There are however significant quantitative discrepancies between their re­ sults. Estimates

  16. 26 CFR 1.992-1 - Requirements of a DISC.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Domestic International Sales Corporations § 1.992-1 Requirements of a DISC. (a) “DISC... corporation which, for a taxable year— (1) Is duly incorporated and existing under the laws of any State...

  17. DISC1 Ser704Cys impacts thalamic-prefrontal connectivity.

    PubMed

    Liu, Bing; Fan, Lingzhong; Cui, Yue; Zhang, Xiaolong; Hou, Bing; Li, Yonghui; Qin, Wen; Wang, Dawei; Yu, Chunshui; Jiang, Tianzi

    2015-01-01

    The Disrupted-in-Schizophrenia 1 (DISC1) gene has been thought as a putative susceptibility gene for various psychiatric disorders, and DISC1 Ser704Cys is associated with variations of brain morphology and function. Moreover, our recent diffusion magnetic resonance imaging (dMRI) study reported that DISC1 Ser704Cys was associated with information transfer efficiency in the brain anatomical network. However, the effects of the DISC1 gene on functional brain connectivity and networks, especially for thalamic-prefrontal circuit, which are disrupted in various psychiatric disorders, are largely unknown. Using a functional connectivity density (FCD) mapping method based on functional magnetic resonance imaging data in a large sample of healthy Han Chinese subjects, we first investigated the association between DISC1 Ser704Cys and short- and long-range FCD hubs. Compared with Ser homozygotes, Cys-allele individuals had increased long-range FCD hubs in the bilateral thalami. The functional and anatomical connectivity of the thalamus to the prefrontal cortex was further analyzed. Significantly increased thalamic-prefrontal functional connectivity and decreased thalamic-prefrontal anatomical connectivity were found in DISC1 Cys-allele carriers. Our findings provide consistent evidence that the DISC1 Ser704Cys polymorphism influences the thalamic-prefrontal circuits in humans and may provide new insights into the neural mechanisms that link DISC1 and the risk for psychiatric disorders. PMID:24146131

  18. Laser Discs, Barcodes, and Books--a Great Combination.

    ERIC Educational Resources Information Center

    Peto, Erica

    1996-01-01

    Describes the use of barcodes to link laser discs with books in school libraries. Highlights include use of a barcode reader as a remote control device as well as a scanner, guidelines for making laser disc books, and a sidebar that explains how to make barcodes and describes software. (LRW)

  19. The SWELLS survey - VI. Hierarchical inference of the initial mass functions of bulges and discs

    NASA Astrophysics Data System (ADS)

    Brewer, Brendon J.; Marshall, Philip J.; Auger, Matthew W.; Treu, Tommaso; Dutton, Aaron A.; Barnabè, Matteo

    2014-01-01

    The long-standing assumption that the stellar initial mass function (IMF) is universal has recently been challenged by a number of observations. Several studies have shown that a `heavy' IMF (e.g. with a Salpeter-like abundance of low-mass stars and thus normalization) is preferred for massive early-type galaxies, while this IMF is inconsistent with the properties of less massive, later-type galaxies. These discoveries motivate the hypothesis that the IMF may vary (possibly very slightly) across galaxies and across components of individual galaxies (e.g. bulges versus discs). In this paper, we use a sample of 19 late-type strong gravitational lenses from the Sloan WFC Edge-on Late-type Lens Survey (SWELLS) to investigate the IMFs of the bulges and discs in late-type galaxies. We perform a joint analysis of the galaxies' total masses (constrained by strong gravitational lensing) and stellar masses (constrained by optical and near-infrared colours in the context of a stellar population synthesis model, up to an IMF normalization parameter). Using minimal assumptions apart from the physical constraint that the total stellar mass m* within any aperture must be less than the total mass mtot within the aperture, we find that the bulges of the galaxies cannot have IMFs heavier (i.e. implying high mass per unit luminosity) than Salpeter, while the disc IMFs are not well constrained by this data set. We also discuss the necessity for hierarchical modelling when combining incomplete information about multiple astronomical objects. This modelling approach allows us to place upper limits on the size of any departures from universality. More data, including spatially resolved kinematics (as in Paper V) and stellar population diagnostics over a range of bulge and disc masses, are needed to robustly quantify how the IMF varies within galaxies.

  20. Fundamental parameters of the close interacting binary HD 170582 and its luminous accretion disc

    NASA Astrophysics Data System (ADS)

    Mennickent, R. E.; Djuraševi?, G.; Cabezas, M.; Cséki, A.; Rosales, J. G.; Niemczura, E.; Araya, I.; Curé, M.

    2015-04-01

    We present a spectroscopic and photometric study of the double period variable HD 170582. Based on the study of the ASAS V-band light curve, we determine an improved orbital period of 16.871 77 ± 0.020 84 d and a long period of 587 d. We disentangled the light curve into an orbital part, determining ephemerides and revealing orbital ellipsoidal variability with unequal maxima, and a long cycle, showing quasi-sinusoidal changes with amplitude ?V= 0.1 mag. Assuming synchronous rotation for the cool stellar component and semidetached configuration we find a cool evolved star of M2 = 1.9 ± 0.1 M?, T2 = 8000 ± 100 K and R2 = 15.6 ± 0.2 R?, and an early B-type dwarf of M1 = 9.0 ± 0.2 M?. The B-type star is surrounded by a geometrically and optically thick accretion disc of radial extension 20.8 ± 0.3 R? contributing about 35 per cent to the system luminosity at the V band. Two extended regions located at opposite sides of the disc rim, and hotter than the disc by 67 and 46 per cent, fit the light-curve asymmetries. The system is seen under inclination 67.4° ± 0.4° and it is found at a distance of 238 ± 10 pc. Specially interesting is the double line nature of He I 5875; two absorption components move in antiphase during the orbital cycle; they can be associated with the shock regions revealed by the photometry. The radial velocity of one of the He I 5875 components closely follows the donor radial velocity, suggesting that the line is formed in a wind emerging near the stream-disc interacting region.

  1. Bending instability in galactic discs: advocacy of the linear theory

    NASA Astrophysics Data System (ADS)

    Rodionov, S. A.; Sotnikova, N. Ya.

    2013-09-01

    We demonstrate that in N-body simulations of isolated disc galaxies, there is numerical vertical heating which slowly increases the vertical velocity dispersion and the disc thickness. Even for models with over a million particles in a disc, this heating can be significant. Such an effect is just the same as in numerical experiments by Sellwood. We also show that in a stellar disc, outside a boxy/peanut bulge, if it presents, the saturation level of the bending instability is rather close to the value predicted by the linear theory. We pay attention to the fact that the bending instability develops and decays very fast, so it cannot play any role in secular vertical heating. However, the bending instability defines the minimal value of the ratio between the vertical and radial velocity dispersions ?z/?R ? 0.3 (so indirectly the minimal thickness), which stellar discs in real galaxies may have. We demonstrate that observations confirm the last statement.

  2. Analytical Investigation on Squeal Phenomena Generated in Bicycle Disc Brakes

    NASA Astrophysics Data System (ADS)

    Nakae, Takashi; Sueoka, Atsuo; Ryu, Takahiro

    The squeal phenomenon is often generated in bicycle disc brakes. This paper deals analytically with the generation mechanism and the criterion of whether or not the squeal occurs. According to the experimental studies, it has been made clear that the squeal is mainly in-plane vibration in the direction of disc surface with the frequency about 1kHz caused by frictional characteristics with negative slope with respect to the relative velocity. An analytical model of the bicycle disc brake system has been devised to confirm the experimental results, in which a coupled in-plane and out-of-plane vibrating system is composed of the disc, hub, caliper and spokes. The resulting frequency of squeal and the unstable vibration modes of the disc and spokes from the analytical model agreed well with the experimental results.

  3. The Influence of a Kinematically Cold Young Component on Disc-Halo Decompositions in Spiral Galaxies: Insights from Solar Neighbourhood K-giants

    E-print Network

    Aniyan, S; Gerhard, O E; Arnaboldi, M; Flynn, C

    2015-01-01

    In decomposing the HI rotation curves of disc galaxies, it is necessary to break a degeneracy between the gravitational fields of the disc and the dark halo by estimating the disc surface density. This is done by combining measurements of the vertical velocity dispersion of the disc with the disc scale height. The vertical velocity dispersion of the discs is measured from absorption lines (near the V-band) of near-face-on spiral galaxies, with the light coming from a mixed population of giants of all ages. However, the scale heights for these galaxies are estimated statistically from near-IR surface photometry of edge-on galaxies. The scale height estimate is therefore dominated by a population of older (> 2 Gyr) red giants. In this paper, we demonstrate the importance of measuring the velocity dispersion for the same older population of stars that is used to estimate the vertical scale height. We present an analysis of the vertical kinematics of K-giants in the solar vicinity. We find the vertical velocity d...

  4. Fiber Optic Rotary Position Transducer

    NASA Astrophysics Data System (ADS)

    Maida, J. L., Jr.; Varshneya, D.

    1988-03-01

    A design for a Fiber Optic Rotary Position Transducer (FORPT) has been developed, and major components tested. This rotary position transducer exhibits a full angular span of 90 (+ or - 45) degrees with an angular resolution of approximately 0.09 degrees (10 bits). The physical dimensions are approximately two inches outside diameter with a thickness of about one inch. The transducer is designed to meet standard military specifications. Its optical telemetry system uses the principle of time division multiplexing. An optical signal processor consisting of an optical transmitter and receiver communicates via a single optical fiber to the transducer. A digitally encoded reflective disc coupled mechanically to a shaft and optically to a fiber optic read head constitutes the actual transduction mechanism.

  5. Magnetised accretion discs in Kerr spacetimes

    NASA Astrophysics Data System (ADS)

    Ranea-Sandoval, Ignacio F.; García, Federico

    2015-01-01

    Context. Observational data from X-ray binary systems provide strong evidence of astronomical objects that are too massive and compact to be explained as neutron or hybrid stars. When these systems are in the thermal (high/soft) state, they emit mainly in the 0.1-5 keV energy range. This emission can be explained by thin accretion discs that formed around compact objects like black holes. The profile of the fluorescent iron line is useful to obtain insight into the nature of the compact object. General relativity does not ensure that a black hole must form after the complete gravitational collapse of very massive stars, and other theoretical models such as naked singularities cannot be discarded. The cosmic censorship conjecture was proposed by Penrose to avoid these possibilities and is yet to be proven. Aims: We study the effect caused by external magnetic fields on the observed thermal spectra and iron line profiles of thin accretion discs formed around Kerr black holes and naked singularities. We aim to provide a tool that can be used to estimate the presence of magnetic fields in the neighbourhood of a compact object and to probe the cosmic censorship conjecture in these particular astrophysical environments. Methods: We developed a numerical scheme able to calculate thermal spectra of magnetised Page-Thorne accretion discs formed around rotating black holes and naked singularities as seen by an arbitrary distant observer. We incorporated two different magnetic field configurations: uniform and dipolar, using a perturbative scheme in the coupling constant between matter and magnetic field strength. Under the same assumptions, we obtained observed synthetic line profiles of the 6.4 keV fluorescent iron line. Results: We show that an external magnetic field produces potentially observable modifications on the thermal energy spectrum and the fluorescent iron line profile. Thermal energy spectra of naked singularities are harder and brighter than those from black holes, and in addition, peak and cut-off energies are affected by the external magnetic field. Moreover, iron line profiles of slowly rotating black holes suffer more changes by a uniform magnetic field, while nearly extremal black holes and naked singularities are more altered in the dipolar case. Based on our calculations, we discard the possibility of modelling the archetypal black-hole candidate in Cygnus X-1 as a naked singularity. Conclusions: Comparison of our models with observational data can be used to probe the cosmic censorship conjecture and to estimate the existence and global geometry of magnetic fields around compact objects by fitting the thermal energy spectra and iron line profiles of X-ray binaries.

  6. Lumbar spinal stenosis is a highly genetic condition partly mediated by disc degeneration

    PubMed Central

    Battié, Michele C.; Ortega-Alonso, Alfredo; Niemelainen, Riikka; Gill, Kevin; Levalahti, Esko; Videman, Tapio; Kaprio, Jaakko

    2014-01-01

    Objectives Lumbar spinal stenosis is one of the most commonly diagnosed spinal disorders in older adults. Although the pathophysiology of the clinical syndrome is not well understood, a narrow central canal or intervertebral foramen is an essential or defining feature. The aim of the present study was to estimate the magnitude of genetic versus environmental influences on central lumbar spinal stenosis, and investigate disc degeneration and stature or bone development as possible genetic pathways. Methods A classic twin study with multivariate analyses considering lumbar level and other covariates was conducted. The study sample comprised 598 male twins (147 monozygotic and 152 dizygotic pairs), 35-70 years of age, from the population-based Finnish Twin Cohort. Primary phenotypes were central lumbar stenosis assessed qualitatively on MRI and quantitatively measured dural sac cross-sectional area. Additional phenotypes to examine possible genetic pathways included disc bulging and standing height, as an indicator of overall skeletal size or development. Results The heritability estimate (h2) for qualitatively assessed central lumbar spinal stenosis on MRI was 67% (95%CI: 56.8-74.5). The broad sense heritability estimate for dural sac cross-sectional area was 81.2% (95%CI: 74.5 – 86.1%), with a similar magnitude of genetic influences across lumbar levels (h2=72.4-75.6). The additive genetic correlation of quantitatively assessed stenosis and disc bulging was extremely high. There was no indication of shared genetic influences between stenosis and stature. Conclusion Central lumbar spinal stenosis and associated dural sac dimensions are highly genetic, and disc degeneration (bulging) appears to be one pathway through which genes influence spinal stenosis. PMID:25155712

  7. High-Speed Recording Performance of Metal Azo Dye Containing Digital Video Disc-Recordable Discs

    NASA Astrophysics Data System (ADS)

    Suzuki, Yuki; Okamoto, Yuuko; Kurose, Yutaka; Maeda, Shuuichi

    1999-03-01

    We have studied the high-speed performance at speeds of 3.5 m/s 14.0 m/s of digital video disc recordable (DVD-R) discs which contain metal azo dyes. Good recording sensitivity and good mark jitter with carrier-to-noise ratio (C/N) > 50 dB at mark lengths of less than 0.40 µm were demonstrated at over 10 m/s due to the high recording responses of the dyes. Furthermore, by introducing the write strategy with pulse trains, the sensitivity difference between mark lengths could be completely eliminated and excellent recording with a jitter value of 8% level has been achieved at 7.0 m/s with a minimum mark length of around 0.4 µm.

  8. Aging Skin

    MedlinePLUS

    ... Submit Home > Healthy Aging > Wellness Healthy Aging Aging skin More information on aging skin When it comes ... early. Return to top More information on Aging skin Read more from womenshealth.gov Varicose Veins and ...

  9. Chandra, XMM-Newton and HST observations of a transient in M31 with a possible asymmetric, precessing disc

    NASA Astrophysics Data System (ADS)

    Barnard, R.; Garcia, M. R.; Murray, S. S.

    2015-06-01

    The transient X-ray source CXOM31 004205.77+411330.43 exhibited several outbursts during our long-term monitoring campaign of approximately monthly observations of the M31 centre with Chandra. However, the decay profile appears to be unlike those observed from Galactic transients. We followed up the 2011 outburst with two ˜B band HST/ACS observations, one in outburst and the other in quiescence, and used difference imaging to search for a counterpart; this would be dominated by reprocessed X-ray emission from the disc. We found a counterpart with B = 28.21 ± 0.16. An XMM-Newton observation from a previous outburst yielded a spectrum that is well described by an absorbed power law with absorption equivalent to ˜2.6 × 1021 H atom cm-2 and photon index ˜1.8; the highest quality Chandra spectrum yielded only ˜130 counts, and best fits consistent with the XMM-Newton results. We calculated an absolute V magnitude of +1.9 during outburst for a typical disc spectrum. An empirical relation between the ratio of X-ray to optical flux and orbital period suggests a period ? 4 h for a black hole accretor. Such a short period is expected to yield an asymmetric, precessing disc, and we propose that the observed decay light curve is due to modulation of the mass transfer rate due to the disc precession.

  10. Doppler-imaging of the planetary debris disc at the white dwarf SDSS J122859.93+104032.9

    E-print Network

    Manser, Christopher J; Marsh, Thomas R; Veras, Dimitri; Koester, Detlev; Breedt, Elmé; Pala, Anna F; Parsons, Steven G; Southworth, John

    2015-01-01

    Debris discs which orbit white dwarfs are signatures of remnant planetary systems. We present twelve years of optical spectroscopy of the metal-polluted white dwarf SDSS J1228+1040, which shows a steady variation in the morphology of the 8600 {\\AA} Ca II triplet line profiles from the gaseous component of its debris disc. We identify additional emission lines of O I, Mg I, Mg II, Fe II and Ca II in the deep co-added spectra. These emission features (including Ca H & K) exhibit a wide range in strength and morphology with respect to each other and to the Ca II triplet, indicating different intensity distributions of these ionic species within the disc. Using Doppler tomography we show that the evolution of the Ca II triplet profile can be interpreted as the precession of a fixed emission pattern with a period in the range 24-30 years. The Ca II line profiles vary on time-scales that are broadly consistent with general relativistic precession of the debris disc.

  11. Photometric evidence of an intermediate-age stellar population in the inner bulge of M31

    NASA Astrophysics Data System (ADS)

    Dong, Hui; Li, Zhiyuan; Wang, Q. Daniel; Lauer, Tod R.; Olsen, Knut A. G.; Saha, Abhijit; Dalcanton, Julianne J.; Williams, Benjamin F.

    2015-08-01

    We explore the assembly history of the M31 bulge within a projected major-axis radius of 180 arcsec (˜680 pc) by studying its stellar populations in Hubble Space Telescope Wide Field Camera 3 and Advanced Camera for Surveys observations. Colours formed by comparing near-ultraviolet versus optical bands are found to become bluer with increasing major-axis radius, which is opposite to that predicted if the sole sources of near-ultraviolet light were old extreme horizontal branch stars with a negative radial gradient in metallicity. Spectral energy distribution fits require a metal-rich intermediate-age stellar population (300 Myr to 1 Gyr old, ˜Z?) in addition to the dominant old population. The radial gradients in age and metallicity of the old stellar population are consistent with those in previous works. For the intermediate-age population, we find an increase in age with radius and a mass fraction that increases up to 2 per cent at 680 pc away from the centre. We exclude contamination from the M31 disc and/or halo as the main origin for this population. Our results thus suggest that intermediate-age stars exist beyond the central 5 arcsec (19 pc) of M31 and contribute ˜1 per cent of the total stellar mass in the bulge. These stars could be related to the secular growth of the M31 bulge.

  12. Disc-geometry homopolar synchronous machine

    NASA Astrophysics Data System (ADS)

    Evans, P. D.; Eastham, J. F.

    1980-09-01

    Results of an experimental and theoretical investigation of a disc-geometry homopolar synchronous machine with field excitation on the primary side are presented. The unlaminated mild-steel rotor contains no windings and is brushless. The prototype machine produces approximately 7.5 kW of mechanical output at 3000 rev/min, with a product of power factor and efficiency greater than 0.7. The construction of the stator core is unusual and incorporates both laminated and unlaminated portions. The magnetic circuit is also arranged to minimize the axial force between the stator and rotor. A novel rotor design which achieves a reduced quadrature-axis reactance is shown experimentally to be superior to the conventional homopolar rotor.

  13. Structure and dynamics of galaxies with a low surface-brightness disc - II. Stellar populations of bulges

    NASA Astrophysics Data System (ADS)

    Morelli, L.; Corsini, E. M.; Pizzella, A.; Dalla Bontà, E.; Coccato, L.; Méndez-Abreu, J.; Cesetti, M.

    2012-06-01

    We present the radial profiles of the H?, Mg and Fe line-strength indices for a sample of eight spiral galaxies with a low-surface-brightness stellar disc and a bulge. The correlations between the central values of the line-strength indices and velocity dispersion are consistent with those known for early-type galaxies and bulges of high-surface-brightness galaxies. The age, metallicity and ?/Fe enhancement of the stellar populations in the bulge-dominated region are obtained using stellar population models with variable element abundance ratios. Almost all the sample bulges are characterized by a young stellar population, ongoing star formation and a solar ?/Fe enhancement. Their metallicity spans from high to subsolar values. No significant gradient in age and ?/Fe enhancement is measured, whereas a negative metallicity gradient is found only in a few cases. These properties suggest that a pure dissipative collapse cannot explain the formation of all the sample bulges and that other phenomena, such as mergers or acquisition events, need to be invoked. Such a picture is also supported by the lack of a correlation between the central value and the gradient of the metallicity in bulges with very low metallicity. The stellar populations of the bulges hosted by low-surface-brightness discs share many properties with those of high-surface-brightness galaxies. Therefore, they are likely to have common formation scenarios and evolution histories. A strong interplay between bulges and discs is ruled out by the fact that, in spite of being hosted by discs with extremely different properties, the bulges of low- and high-surface-brightness discs are remarkably similar. Based on observations made with European Southern Observatory telescopes at the La Silla Paranal Observatory under programmes 76.B-0375 and 80.B-00754.

  14. Who should have Surgery for an Intervertebral Disc Herniation?

    PubMed Central

    Pearson, Adam; Lurie, Jon; Tosteson, Tor; Zhao, Wenyan; Abdu, William; Mirza, Sohail; Weinstein, James

    2012-01-01

    Study Design Combined prospective randomized controlled trial and observational cohort study of intervertebral disc herniation (IDH), an as-treated analysis. Objective To determine modifiers of the treatment effect (TE) of surgery (the difference between surgical and nonoperative outcomes) for intervertebral disc herniation (IDH) using subgroup analysis. Summary of Background Data SPORT demonstrated a positive surgical TE for IDH at the group level. However, individual characteristics may affect TE. No prior studies have evaluated TE modifiers in IDH. Methods IDH patients underwent either discectomy (n=788) or nonoperative care (n=404) and were analyzed according to treatment received. Thirty-seven baseline variables were used to define subgroups for calculating the time-weighted average TE for the Oswestry Disability Index (ODI) over 4 years (TE=?ODIsurgery-?ODInonoperative). Variables with significant subgroup by* treatment interactions (p<0.1) were simultaneously entered into a multivariate model to select independent TE predictors. Results All analyzed subgroups improved significantly more with surgery than with nonoperative treatment (p<0.05). In minimally adjusted univariate analyses: being married, absence of joint problems, worsening symptom trend at baseline, high school education or less, older age, no worker’s compensation, longer duration of symptoms, and an SF-36 mental component score (MCS) less than 35 were associated with greater TEs. Multivariate analysis demonstrated: being married (TE ?15.8 vs. ?7.7 single, p<0.001), absence of joint problems (TE ?14.6 vs. ?10.3 joint problems, p=0.012), and worsening symptoms (TE ?15.9 vs. ?11.8 stable symptoms, p=0.032) were independent TE modifiers. TE’s were greatest in married patients with worsening symptoms (?18.3) vs. single patients with stable symptoms (?7.8). Conclusions IDH patients who met strict inclusion criteria improved more with surgery than with nonoperative treatment, regardless of specific characteristics. However, being married, without joint problems, and worsening symptom trend at baseline were associated with a greater treatment effect. PMID:21681140

  15. Optic nerve hypoplasia

    PubMed Central

    Kaur, Savleen; Jain, Sparshi; Sodhi, Harsimrat B. S.; Rastogi, Anju; Kamlesh

    2013-01-01

    Optic nerve hypoplasia (ONH) is a congenital anomaly of the optic disc that might result in moderate to severe vision loss in children. With a vast number of cases now being reported, the rarity of ONH is obviously now refuted. The major aspects of ophthalmic evaluation of an infant with possible ONH are visual assessment, fundus examination, and visual electrophysiology. Characteristically, the disc is small, there is a peripapillary double-ring sign, vascular tortuosity, and thinning of the nerve fiber layer. A patient with ONH should be assessed for presence of neurologic, radiologic, and endocrine associations. There may be maternal associations like premature births, fetal alcohol syndrome, maternal diabetes. Systemic associations in the child include endocrine abnormalities, developmental delay, cerebral palsy, and seizures. Besides the hypoplastic optic nerve and chiasm, neuroimaging shows abnormalities in ventricles or white- or gray-matter development, septo-optic dysplasia, hydrocephalus, and corpus callosum abnormalities. There is a greater incidence of clinical neurologic abnormalities in patients with bilateral ONH (65%) than patients with unilateral ONH. We present a review on the available literature on the same to urge caution in our clinical practice when dealing with patients with ONH. Fundus photography, ocular coherence tomography, visual field testing, color vision evaluation, neuroimaging, endocrinology consultation with or without genetic testing are helpful in the diagnosis and management of ONH. (Method of search: MEDLINE, PUBMED). PMID:24082663

  16. The circumstellar disc, envelope and bipolar outflow of the massive young stellar object W33A

    NASA Astrophysics Data System (ADS)

    Davies, Ben; Lumsden, Stuart L.; Hoare, Melvin G.; Oudmaijer, René D.; de Wit, Willem-Jan

    2010-03-01

    The young stellar object (YSO) W33A is one of the best known examples of a massive star still in the process of forming. Here we present Gemini North Altitude conjugate Adaptive optics for the Infrared (ALTAIR)/Near-Infrared Integral Field Spectrograph laser-guide star adaptive-optics assisted K-band integral-field spectroscopy of W33A and its inner reflection nebula. In our data, we make the first detections of a rotationally flattened outer envelope and fast bipolar jet of a massive YSO at near-infrared wavelengths. The predominant spectral features observed are Br?, H2 and a combination of emission and absorption from CO gas. We perform a 3D spectro-astrometric analysis of the line emission, the first study of its kind. We find that the object's Br? emission reveals evidence for a fast bipolar jet on sub-milliarcsecond scales, which is aligned with the larger scale outflow. The hybrid CO features can be explained as a combination of hot CO emission arising in a disc close to the central star, while cold CO absorption originates in the cooler outer envelope. Kinematic analysis of these features reveals that both structures are rotating and consistent with being aligned perpendicular to both the ionized jet and the large-scale outflow. Assuming Keplerian rotation, we find that the circumstellar disc orbits a central mass of >~10Msolar, while the outer envelope encloses a mass of ~15Msolar. Our results suggest a scenario of a central star accreting material from a circumstellar disc at the centre of a cool extended rotating torus, while driving a fast bipolar wind. These results therefore provide strong supporting evidence for the hypothesis that the formation mechanism for high-mass stars is qualitatively similar to that of low-mass stars.

  17. Percutaneous treatment of cervical and lumbar herniated disc.

    PubMed

    Kelekis, A; Filippiadis, D K

    2015-05-01

    Therapeutic armamentarium for symptomatic intervertebral disc herniation includes conservative therapy, epidural infiltrations (interlaminar or trans-foraminal), percutaneous therapeutic techniques and surgical options. Percutaneous, therapeutic techniques are imaging-guided, minimally invasive treatments for intervertebral disc herniation which can be performed as outpatient procedures. They can be classified in 4 main categories: mechanical, thermal, chemical decompression and biomaterials implantation. Strict sterility measures are a prerequisite and should include extensive local sterility and antibiotic prophylaxis. Indications include the presence of a symptomatic, small to medium sized contained intervertebral disc herniation non-responding to a 4-6 weeks course of conservative therapy. Contraindications include sequestration, infection, segmental instability (spondylolisthesis), uncorrected coagulopathy or a patient unwilling to provide informed consent. Decompression techniques are feasible and reproducible, efficient (75-94% success rate) and safe (>0.5% mean complications rate) therapies for the treatment of symptomatic intervertebral disc herniation. Percutaneous, imaging guided, intervertebral disc therapeutic techniques can be proposed either as an initial treatment or as an attractive alternative prior to surgery for the therapy of symptomatic herniation in both cervical and lumbar spine. This article will describe the mechanism of action for different therapeutic techniques applied to intervertebral discs of cervical and lumbar spine, summarize the data concerning safety and effectiveness of these treatments, and provide a rational approach for the therapy of symptomatic intervertebral disc herniation in cervical and lumbar spine. PMID:24673977

  18. Accretion of the Moon from non-canonical discs

    PubMed Central

    Salmon, J.; Canup, R. M

    2014-01-01

    Impacts that leave the Earth–Moon system with a large excess in angular momentum have recently been advocated as a means of generating a protolunar disc with a composition that is nearly identical to that of the Earth's mantle. We here investigate the accretion of the Moon from discs generated by such ‘non-canonical’ impacts, which are typically more compact than discs produced by canonical impacts and have a higher fraction of their mass initially located inside the Roche limit. Our model predicts a similar overall accretional history for both canonical and non-canonical discs, with the Moon forming in three consecutive steps over hundreds of years. However, we find that, to yield a lunar-mass Moon, the more compact non-canonical discs must initially be more massive than implied by prior estimates, and only a few of the discs produced by impact simulations to date appear to meet this condition. Non-canonical impacts require that capture of the Moon into the evection resonance with the Sun reduced the Earth–Moon angular momentum by a factor of 2 or more. We find that the Moon's semi-major axis at the end of its accretion is approximately 7R?, which is comparable to the location of the evection resonance for a post-impact Earth with a 2.5?h rotation period in the absence of a disc. Thus, the dynamics of the Moon's assembly may directly affect its ability to be captured into the resonance. PMID:25114307

  19. Disc fragmentation rarely forms planetary-mass objects

    NASA Astrophysics Data System (ADS)

    Rice, Ken; Lopez, Eric; Forgan, Duncan; Biller, Beth

    2015-12-01

    It is now reasonably clear that disc fragmentation can only operate in the outer parts of protostellar discs (r > 50 au). It is also expected that any object that forms via disc fragmentation will have an initial mass greater than that of Jupiter. However, whether or not such a process actually operates, or can play a significant role in the formation of planetary-mass objects, is still unclear. We do have a few examples of directly imaged objects that may have formed in this way, but we have yet to constrain how often disc fragmentation may actually form such objects. What we want to consider here is whether or not we can constrain the likely population of planetary-mass objects formed via disc fragmentation by considering how a population of objects at large radii (a > 50) au - if they do exist - would evolve under perturbations from more distant stellar companions. We find that there is a specific region of parameter space to which such objects would be scattered and show that the known exoplanets in that region have properties more consistent with that of the bulk exoplanet population, than with having been formed via disc fragmentation at large radii. Along with the scarcity of directly imaged objects at large radii, our results provide a similar, but independent, constraint on the frequency of objects formed via disc fragmentation.

  20. On the vertical-shear instability in astrophysical discs

    NASA Astrophysics Data System (ADS)

    Barker, A. J.; Latter, H. N.

    2015-06-01

    We explore the linear stability of astrophysical discs exhibiting vertical shear, which arises when there is a radial variation in the temperature or entropy. Such discs are subject to a `vertical-shear instability', which recent non-linear simulations have shown to drive hydrodynamic activity in the MRI-stable regions of protoplanetary discs. We first revisit locally isothermal discs using the quasi-global reduced model derived by Nelson et al. This analysis is then extended to global axisymmetric perturbations in a cylindrical domain. We also derive and study a reduced model describing discs with power-law radial entropy profiles (`locally polytropic discs'), which are somewhat more realistic in that they possess physical (as opposed to numerical) surfaces. The fastest growing modes have very short wavelengths and are localized at the disc surfaces (if present), where the vertical shear is maximal. An additional class of modestly growing vertically global body modes is excited, corresponding to destabilized classical inertial waves (`r modes'). We discuss the properties of both types of modes, and stress that those that grow fastest occur on the shortest available length-scales (determined either by the numerical grid or the physical viscous length). This ill-posedness makes simulations of the instability difficult to interpret. We end with some brief speculation on the non-linear saturation and resulting angular momentum transport.

  1. Does the stellar disc flattening depend on the galaxy type?

    E-print Network

    Mosenkov, A V; Reshetnikov, V P; Bizyaev, D V; Kautsch, S J

    2015-01-01

    We analyze the dependence of the stellar disc flatness on the galaxy morphological type using 2D decomposition of galaxies from the reliable subsample of the Edge-on Galaxies in SDSS (EGIS) catalogue. Combining these data with the retrieved models of the edge-on galaxies from the Two Micron All Sky Survey (2MASS) and the Spitzer Survey of Stellar Structure in Galaxies (S$^4$G) catalogue, we make the following conclusions: (1) The disc relative thickness $z_0/h$ in the near- and mid-infrared passbands correlates weakly with morphological type and does not correlate with the bulge-to-total luminosity ratio $B/T$ in all studied bands. (2) Applying an 1D photometric profile analysis overestimates the disc thickness in galaxies with large bulges making an illusion of the relationship between the disc flattening and the ratio $B/T$. (3) In our sample the early-type disc galaxies (S0/a) have both flat and "puffed" discs. The early spirals and intermediate-type galaxies have a large scatter of the disc flatness, whic...

  2. Accretion of the Moon from non-canonical discs.

    PubMed

    Salmon, J; Canup, R M

    2014-09-13

    Impacts that leave the Earth-Moon system with a large excess in angular momentum have recently been advocated as a means of generating a protolunar disc with a composition that is nearly identical to that of the Earth's mantle. We here investigate the accretion of the Moon from discs generated by such 'non-canonical' impacts, which are typically more compact than discs produced by canonical impacts and have a higher fraction of their mass initially located inside the Roche limit. Our model predicts a similar overall accretional history for both canonical and non-canonical discs, with the Moon forming in three consecutive steps over hundreds of years. However, we find that, to yield a lunar-mass Moon, the more compact non-canonical discs must initially be more massive than implied by prior estimates, and only a few of the discs produced by impact simulations to date appear to meet this condition. Non-canonical impacts require that capture of the Moon into the evection resonance with the Sun reduced the Earth-Moon angular momentum by a factor of 2 or more. We find that the Moon's semi-major axis at the end of its accretion is approximately 7R?, which is comparable to the location of the evection resonance for a post-impact Earth with a 2.5?h rotation period in the absence of a disc. Thus, the dynamics of the Moon's assembly may directly affect its ability to be captured into the resonance. PMID:25114307

  3. Gap formation and stability in non-isothermal protoplanetary discs

    NASA Astrophysics Data System (ADS)

    Les, Robert; Lin, Min-Kai

    2015-06-01

    Several observations of transition discs show lopsided dust distributions. A potential explanation is the formation of a large-scale vortex acting as a dust-trap at the edge of a gap opened by a giant planet. Numerical models of gap-edge vortices have so far employed locally isothermal discs in which the temperature profile is held fixed, but the theory of this vortex-forming or `Rossby wave' instability was originally developed for adiabatic discs. We generalize the study of planetary gap stability to non-isothermal discs using customized numerical simulations of disc-planet systems where the planet opens an unstable gap. We include in the energy equation a simple cooling function with cooling time-scale t_c=? ? _k^{-1}, where ?k is the Keplerian frequency, and examine the effect of ? on the stability of gap edges and vortex lifetimes. We find increasing ? lowers the growth rate of non-axisymmetric perturbations, and the dominant azimuthal wavenumber m decreases. We find a quasi-steady state consisting of one large-scale, overdense vortex circulating the outer gap edge, typically lasting O(103) orbits. We find vortex lifetimes generally increase with the cooling time-scale tc up to an optimal value of tc ˜ 10 orbits, beyond which vortex lifetimes decrease. This non-monotonic dependence is qualitatively consistent with recent studies using strictly isothermal discs that vary the disc aspect ratio. The lifetime and observability of gap-edge vortices in protoplanetary discs is therefore dependent on disc thermodynamics.

  4. Local and global dynamics of warped astrophysical discs

    NASA Astrophysics Data System (ADS)

    Ogilvie, Gordon I.; Latter, Henrik N.

    2013-08-01

    Astrophysical discs are warped whenever a misalignment is present in the system, or when a flat disc is made unstable by external forces. The evolution of the shape and mass distribution of a warped disc is driven not only by external influences but also by an internal torque, which transports angular momentum through the disc. This torque depends on internal flows driven by the oscillating pressure gradient associated with the warp, and on physical processes operating on smaller scales, which may include instability and turbulence. We introduce a local model for the detailed study of warped discs. Starting from the shearing sheet of Goldreich and Lynden-Bell, we impose the oscillating geometry of the orbital plane by means of a coordinate transformation. This warped shearing sheet (or box) is suitable for analytical and computational treatments of fluid dynamics, magnetohydrodynamics, etc., and it can be used to compute the internal torque that drives the large-scale evolution of the disc. The simplest hydrodynamic states in the local model are horizontally uniform laminar flows that oscillate at the orbital frequency. These correspond to the non-linear solutions for warped discs found in previous work by Ogilvie, and we present an alternative derivation and generalization of that theory. In a companion paper, we show that these laminar flows are often linearly unstable, especially if the disc is nearly Keplerian and of low viscosity. The local model can be used in future work to determine the non-linear outcome of the hydrodynamic instability of warped discs, and its interaction with others such as the magnetorotational instability.

  5. Test-Retest Reliability of the Chinese Version of the Diagnostic Interview Schedule for Children-Version 4 (DISC-IV)

    ERIC Educational Resources Information Center

    Ho, Ting-Pong; Leung, Patrick Wing-leung; Lee, Chi-chiu; Tang, Chun-pan; Hung, Se-fong; Kwong, Shi-leung; Lucas, Christopher P.; Lieh-Mak, Felice; Shaffer, David

    2005-01-01

    Background: Despite the huge youth population, there is a lack of psychiatric diagnostic instruments with reported psychometric properties in Chinese. This study reports the development of the Chinese version of DISC-IV and examines its test-retest reliability. Method: Seventy-eight parents and 79 youths (mean age 13.1 years) attending child…

  6. Cervical Disc Injury—Symptoms and Conservative Treatment

    PubMed Central

    Gorham, F. W.

    1964-01-01

    Primary traumatic cervical disc disease and chronic disc disease associated with spondylitis aggravated by injury causes referred pain to the head, face, neck, arms, shoulders and chest, and even in the low back. Such pain may be reproduced by the injection of contrast medium for cervical discography. Dorsal nerve root pain is rare. Clear-cut disc derangement or annular incompetence may be demonstrated by discography at levels which reproduce symptoms. The pain pattern at each level is not consistent. Conservative treatment, involving primarily the use of a cervical extension collar, results in substantial improvement in 75 per cent of cases. PMID:14229745

  7. Simple solutions of multilayered discs subjected to biaxial moment loading.

    SciTech Connect

    Hsueh, Chun-Hway; Kelly, J R

    2009-01-01

    The purpose of this study was to derive a simple closed-form solution for the stress distribution through the thickness of multilayered discs subjected to biaxial moment loading, such that it can be used readily to evaluate the biaxial strength of multilayered dental ceramics using biaxial flexure tests. Methods A simple analytical model was developed to derive the stress distribution through the thickness of multilayered discs subjected to biaxial moment loading. The accuracy of the solution was verified by comparing with previous rigorous analytical solutions and finite element results. The results obtained from Roark's formulas for bilayered discs were also included for comparison.

  8. Hot Jupiters and Central Cavities of Protoplanetary Discs

    E-print Network

    Szymon Starczewski; Artur J. Gawryszczak; Richard Wunsch; Michal Rozyczka

    2007-11-12

    We investigate numerically the orbital evolution of massive extrasolar planets within central cavities of their parent protoplanetary discs. Assuming that they arrive at the inner edge of the disc due to type II migration, we show that they spiral further in. We find that in magnetospheric cavities more massive planets stop migrating at a larger distance from the edge of the disc. This effect may qualitatively explain the correlation between masses and orbital periods found for massive planets with P shorter than 5 days.

  9. Constraining the thick disc formation scenario of the Milky Way

    NASA Astrophysics Data System (ADS)

    Robin, A. C.; Reylé, C.; Fliri, J.; Czekaj, M.; Robert, C. P.; Martins, A. M. M.

    2014-09-01

    Aims: More than 30 years after its discovery, the thick disc of the Milky Way is not fully explored. We examine the shape of the thick disc in order to gain insight into the process of its formation. Methods: The shape of the thick disc is studied in detail using photometric data at high and intermediate latitudes from SDSS and 2MASS surveys. We adopted the population synthesis approach using an approximate Bayesian computation - Markov chain Monte Carlo (ABC-MCMC) method to determine the potential degeneracies in the parameters that can be caused by the mixing with the halo and the thin disc. We characterised the thick-disc shape, scale height, scale length, local density, and flare, and we investigated the extent of the thick-disc formation period by simulating several formation episodes. Results: We find that the vertical variation in density is not exponential, but much closer to a hyperbolic secant squared. Assuming a single formation epoch, the thick disc is better fitted with a sech2 scale height of 470 pc and a scale length of 2.3 kpc. However, if one simulates two successive formation episodes, which mimicks an extended formation period, the older episode has a higher scale height and a longer scale length than the younger episode, which indicates a contraction during the collapse phase. The scale height decreases from 800 pc to 340 pc, the scale length from 3.2 kpc to 2 kpc. The likelihood is much higher when the thick disc formation extends over a longer period. We also show that star formation increases from the old episode to the young and that there is no flare in the outskirt of the thick disc during the main episode. We compare our results with formation scenarios of the thick disc. During the fitting process, the halo parameters are determined as well. If a power-law density is assumed, it has an exponent of 3.3 and an axis ratio of 0.7. Alternatively, a Hernquist shape would have an exponent of 2.76, an axis ratio of 0.77, and a core radius of 2.1 kpc. The constraint on the halo shows that a transition between an inner and outer halo, if it exists, cannot be at a distance shorter than about 30 kpc, which is the limit of our investigation using turnoff halo stars. Finally, we show that extrapolating the thick disc towards the bulge region explains well the stellar populations observed there that there is no longer need to invoke a classical bulge. Conclusions: The facts that the thick-disc episode lasted for several billion years, that a contraction is observed during the collapse phase, and that the main thick disc has a constant scale height with no flare argue against the formation of the thick disc through radial migration. The most probable scenario for the thick disc is that it formed while the Galaxy was gravitationally collapsing from well-mixed gas-rich giant clumps that were sustained by high turbulence, which prevented a thin disc from forming for a time, as proposed previously. This scenario explains well the observations in the thick-disc region and in the bulge region. Figures 8-11 and Appendix A are available in electronic form at http://www.aanda.org

  10. Braking down an accreting protostar: disc-locking, disc winds, stellar winds, X-winds and Magnetospheric Ejecta

    NASA Astrophysics Data System (ADS)

    Ferreira, J.

    2013-09-01

    Classical T Tauri stars are low mass young forming stars that are surrounded by a circumstellar accretion disc from which they gain mass. Despite this accretion and their own contraction that should both lead to their spin up, these stars seem to conserve instead an almost constant rotational period as long as the disc is maintained. Several scenarios have been proposed in the literature in order to explain this puzzling "disc-locking" situation: either deposition in the disc of the stellar angular momentum by the stellar magnetosphere or its ejection through winds, providing thereby an explanation of jets from Young Stellar Objects. In this lecture, these various mechanisms will be critically detailed, from the physics of the star-disc interaction to the launching of self-confined jets (disc winds, stellar winds, X-winds, conical winds). It will be shown that no simple model can account alone for the whole bulk of observational data and that "disc locking" requires a combination of some of them.

  11. DETAIL OF DENVER DISC FILTER IN CO91107, SUCTION END. NOTE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL OF DENVER DISC FILTER IN CO-91-107, SUCTION END. NOTE BEARING HOUSING WITH CAST LOGO, SUCTION PIPE GOING OFF TO THE RIGHT, AND FILTER DISC IN BACKGROUND. VACUUM INSIDE DISCS FURTHER DEWATERED CONCENTRATE. AS DISC SLOWLY ROTATED A BAR SCRAPED DRIED CONCENTRATE FROM OUTSIDE OF FILTER CLOTH. - Shenandoah-Dives Mill, 135 County Road 2, Silverton, San Juan County, CO

  12. 26 CFR 1.995-1 - Taxation of DISC income to shareholders.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...2011-04-01 2011-04-01 false Taxation of DISC income to shareholders. 1...Sales Corporations § 1.995-1 Taxation of DISC income to shareholders. ...DISC, or a former DISC, are subject to taxation on the earnings and profits of...

  13. 26 CFR 1.995-1 - Taxation of DISC income to shareholders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...2010-04-01 2010-04-01 false Taxation of DISC income to shareholders. 1...Sales Corporations § 1.995-1 Taxation of DISC income to shareholders. ...DISC, or a former DISC, are subject to taxation on the earnings and profits of...

  14. Testing large-scale vortex formation against viscous layers in three-dimensional discs

    E-print Network

    Lin, Min-Kai

    2013-01-01

    Vortex formation through the Rossby wave instability (RWI) in protoplanetary discs has been invoked to play a role in planet formation theory, and suggested to explain the observation of large dust asymmetries in several transitional discs. However, whether or not vortex formation operates in layered accretion discs, i.e. models of protoplanetary discs including dead zones near the disc