Immunitary bioeconomy: the economisation of life in the international cord blood market.

PubMed

Brown, Nik; Machin, Laura; McLeod, Danae

2011-04-01

This paper examines an emerging bioeconomy centred on the international banking and trade in cord blood. Since the late 1980s cord blood has been used in an expanding range of treatments and as an alternative to the use of bone marrow stem cells. This is particularly the case in treating ethnic minority populations who have historically been under-represented in bone marrow registries. The paper explores the mobilisation and commercialisation of an increasingly important bioeconomic resource with cord blood units trading internationally at high prices. This is a market mediated through a sophisticated global network of immunologically typed and matched bodily matter in which immunity has become a form of 'corporeal currency'. Based on recent international figures we reflect upon the balance of trade between imports and exports across the world's cord blood bioeconomy. Theoretically, this case is, we suggest, an extension of what Roberto Esposito (2008) has termed an 'immunitary paradigm' in which immunity has become the basis for new forms of bioeconomic flow, circulation and exchange. Esposito (2008). Bios: Biopolitics and Philosophy. Minnesota, MN: University of Minnesota Press. Copyright © 2011 Elsevier Ltd. All rights reserved.

The Case for Massive and Ancient Rings of Saturn

NASA Astrophysics Data System (ADS)

Esposito, Larry W.

2016-04-01

Analysis of Voyager and Pioneer 11 results give a mass for Saturn's rings, M = 5 x 10-8 Msat. This is about the mass of Saturn's small moon Mimas. This has been interpreted as a lower limit to the ring mass (Esposito et al 1983), since the thickest parts of the rings were not penetrated by the stellar occultstion, and this calculation assumes an unvarying particle size throughout the rings. Because the rings are constantly bombarded by micrometeroids, their current composition of nearly pure water ice implies such low mass rings must have formed recently. The case is par-ticularly strong for Saturn's A ring, where the data are the best, implying the A ring is less than 10% of the age of the Saturn (Esposito 1986). Cassini results com-pound this problem. UVIS spectra are consistent with either young rings or rings about 10x as massive as the Voyager estimate (Elliott and Esposito (2011). CDA confirms the impacting mass flux is similar to that as-sumed for the pollution calculations (Kempf etal 2015). VIMS analysis of density wave signatures in the B ring gives a value of about 1/3 the Voyager value (Hedmann etal 2016). This VIMS result implies the rings are even younger! The problem is that young rings are very unlikely to be formed recently, meaning that we live in a very special epoch, following some unlikely recent origin… like disruption of a medium sized moon or capture of the fragments of a disrupted comet. This paradox (Charnoz etal 2009) is unre-solved. Alternative interpretations: To take the VIMS results at face value, Saturn's low mass rings must be very young. The optically thick B ring must be made of small, porous or fractal particles. This is hard to understand, since the particles are continually colliding every few hours and temporary aggregates will stir the collision velocities to higher values. An alternative is that we accept the higher mass interpretation of the Pioneer 11 results (Esposito etal 2008) using the granola bar model of Colwell

Effect of cosmological evolution on Solar System constraints and on the scalarization of neutron stars in massless scalar-tensor theories

NASA Astrophysics Data System (ADS)

Anderson, David; Yunes, Nicolás; Barausse, Enrico

2016-11-01

Certain scalar-tensor theories of gravity that generalize Jordan-Fierz-Brans-Dicke theory are known to predict nontrivial phenomenology for neutron stars. In these theories, first proposed by Damour and Esposito-Farèse, the scalar field has a standard kinetic term and couples conformally to the matter fields. The weak equivalence principle is therefore satisfied, but scalar effects may arise in strong-field regimes, e.g., allowing for violations of the strong equivalence principle in neutron stars ("spontaneous scalarization") or in sufficiently tight binary neutron-star systems ("dynamical/induced scalarization"). The original scalar-tensor theory proposed by Damour and Esposito-Farèse is in tension with Solar System constraints (for couplings that lead to scalarization), if one accounts for cosmological evolution of the scalar field and no mass term is included in the action. We extend here the conformal coupling of that theory, in order to ascertain if, in this way, Solar System tests can be passed, while retaining a nontrivial phenomenology for neutron stars. We find that, even with this generalized conformal coupling, it is impossible to construct a theory that passes both big bang nucleosynthesis and Solar System constraints, while simultaneously allowing for scalarization in isolated/binary neutron stars.

American Jihadist Terrorism: Combating a Complex Threat

DTIC Science & Technology

2010-12-07

Esposito, “Terror Raids at JFK Airport Net American Alleged Terror Plotters Headed for Somalia,” abcnews.com, June 6, 2010, http://abcnews.go.com...Blotter/terror-raids- jfk - airport -net-alleged-terror-plotters/story?id= 10839045. 186 U.S. v. Mohamed Alessa and Carlos E. Almonte, Criminal Complaint... Airport Net American Alleged Terror Plotters Headed for Somalia,” ABC News, June 6, 2010, http://abcnews.go.com/Blotter/terror-raids- jfk - airport -net

The Rings of Saturn

NASA Astrophysics Data System (ADS)

Cuzzi, J. N.; Filacchione, G.; Marouf, E. A.

2018-03-01

One could become an expert on Saturn's iconic rings pretty easily in the early 1970s, as very little was known about them beyond the distinction between the A, B, and C rings, and the Cassini Division or "gap" between rings A and B (Alexander, 1962; Bobrov, 1970). Water ice was discovered spectroscopically on the ring particle surfaces, and radar and microwave emission observations proved that the particles must be centimeters to meters in size, consisting primarily, not just superficially, of water ice (Pollack, 1975). While a 2:1 orbital resonance with Mimas had long been suspected of having something to do with the Cassini Division, computers of the time were unable to model the subtle dynamical effects that we now know to dominate ring structure. This innocent state of affairs was exploded by the Voyager 1 and 2 encounters in 1980 and 1981. Spectacular images revealed filigree structure and odd regional color variations, and exquisitely detailed radial profiles of fluctuating particle abundance were obtained from the first stellar and radio occultations, having resolution almost at the scale of single particles. Voyager-era understanding was reviewed by Cuzzi et al. (1984) and Esposito et al. (1984). While the Voyager data kept ring scientists busy for decades, planning which led to the monumentally successful NASA-ESA-ASI Cassini mission, which arrived in 2004, had been under way even before Voyager got to Saturn. A review of pre-Cassini knowledge of Saturn's Rings can be found in Orton et al. (2009). This chapter will build on recent topical and process-specific reviews that treat the gamut of ring phenomena and its underlying physics in considerable detail (Colwell et al., 2009; Cuzzi et al., 2009; Horányi et al., 2009; Schmidt et al., 2009; Esposito, 2010; Tiscareno, 2013b; Esposito, 2014). We will follow and extend the general organization of Cuzzi et al. (2010), the most recent general discussion of Saturn's rings. For brevity and the benefit of the

American Jihadist Terrorism: Combating a Complex Threat

DTIC Science & Technology

2010-09-20

www.nytimes.com/2010/07/30/us/30fbi.html. 177 Richard Esposito, “Terror Raids at JFK Airport Net American Alleged Terror Plotters Headed for Somalia...abcnews.com, June 6, 2010, http://abcnews.go.com/Blotter/terror-raids- jfk - airport -net-alleged-terror-plotters/story?id= 10839045. 178 U.S. v. Mohamed... Airport Net American Alleged Terror Plotters Headed for Somalia,” ABC News, June 6, 2010, http://abcnews.go.com/Blotter/terror-raids- jfk - airport -net

A Request for the Conference and Symposia Grant from COMP Division of American Chemical Society

DTIC Science & Technology

2015-03-02

John Kattirtzi, Joost VandeVondele, Jun Cheng. 4:45 pm 130 Oxidation stability and decomposition reactions of battery electrolytes and additives in bulk...CA Abstracts2View™: http://abstracts.acs.org/chem/248nm/program/divisionindex.php?act=pre... 3 of 5 8/26/2014 8:19 PM 11:10 am 420 DME decomposition ...Nature of electro-osmosis in hydrated polymer electrolyte membranes Yoong-Kee Choe 5:25 pm Concluding Remarks COMP Emilio Esposito, Scott Wildman

Environmental Assessment: Hurricane Katrina Recovery and Installation Development at Keesler Air Force Base, Mississippi

DTIC Science & Technology

2006-12-01

ly Sweeney Jef fe rso n D avi s Ze ro M a u villa Foulois Fe che t Cabell Esposito Percy Thunderbolt James Ar nol d Pine Lawn Monroe W all Bilm arsan... Jackson counties in Mississippi. These three counties encompass 1,785 square miles of land area and comprise the entire coastline of Mississippi along the...24.2% Hancock County 46,711 11.6% 15.7% 23.4% Harrison County 193,810 29.8% 16.5% 25.7% Jackson County 135,940 27.6% 15.0% 25.8% Biloxi MSA 376,461

The imprint of Gould's belt on the local cosmic ray electron spectrum

NASA Astrophysics Data System (ADS)

Pohl, M.; Perrot, C.; Grenier, I.

2001-08-01

In a recent paper Pohl and Esposito (1998) demonstrated that if the sources of cosmic-rays are discrete, as are Supernova Remnants (SNR), then the spectra of cosmic-ray electrons largely vary with location and time and the locally measured electron spectrum may not be representative of the electron spectra elsewhere in the Galaxy, which could be substantially harder than the local one. They have shown that the observed excess of γ-ray emission above 1 GeV can in fact be partially explained as a correspondingly hard inverse Compton component, provided the bulk of cosmic-ray electrons is produced in SNR. As part of a program to model the Galactic γ-ray foreground we have continued the earlier studies by investigating the impact of the star forming region Gould's Belt on the local electron spectrum. If the electron sources in Gould's Belt were continous, the local electron spectrum would be slightly hardened. If the electron sources are discrete, which is the more probable case, the variation in the local electron spectrum found by Pohl & Esposito persists. 1 The local cosmic-ray electron spectrum The recent detections of non-thermal X-ray synchrotron radiation from the supernova remnants SN1006 (Koyama et al., 1995), RX J1713.7-3946 (Koyama et al., 1997), IC443 (Keohane et al., 1997; Slane et al., 1999), Cas A (Allen et al., 1997), and RCW86 (Borkowski et al., 2001) and the subsequent detections of SN1006 (Tanimori et al., 1998), RX J1713.7-3946 (Muraishi et al., 2000), and Cas A (Aharonian et al., 2001) at TeV energies support the hypothesis that at least Galactic cosmic-ray electrons are accelerated predominantly in SNR. The Galactic distribution and spectrum of cosmic-ray electrons are intimately linked to the distribution and nature of their sources. Supernovae and hence their remnants are tran-

Mitosis-associated repression in development.

PubMed

Esposito, Emilia; Lim, Bomyi; Guessous, Ghita; Falahati, Hanieh; Levine, Michael

2016-07-01

Transcriptional repression is a pervasive feature of animal development. Here, we employ live-imaging methods to visualize the Snail repressor, which establishes the boundary between the presumptive mesoderm and neurogenic ectoderm of early Drosophila embryos. Snail target enhancers were attached to an MS2 reporter gene, permitting detection of nascent transcripts in living embryos. The transgenes exhibit initially broad patterns of transcription but are refined by repression in the mesoderm following mitosis. These observations reveal a correlation between mitotic silencing and Snail repression. We propose that mitosis and other inherent discontinuities in transcription boost the activities of sequence-specific repressors, such as Snail. © 2016 Esposito et al.; Published by Cold Spring Harbor Laboratory Press.

Implications of hidden gauged U (1 ) model for B anomalies

NASA Astrophysics Data System (ADS)

Fuyuto, Kaori; Li, Hao-Lin; Yu, Jiang-Hao

2018-06-01

We propose a hidden gauged U (1 )H Z' model to explain deviations from the standard model (SM) values in lepton flavor universality known as RK and RD anomalies. The Z' only interacts with the SM fermions via their mixing with vectorlike doublet fermions after the U (1 )H symmetry breaking, which leads to b →s μ μ transition through the Z' at tree level. Moreover, introducing an additional mediator, inert-Higgs doublet, yields b →c τ ν process via charged scalar contribution at tree level. Using flavio package, we scrutinize adequate sizes of the relevant Wilson coefficients to these two processes by taking various flavor observables into account. It is found that significant mixing between the vectorlike and the second generation leptons is needed for the RK anomaly. A possible explanation of the RD anomaly can also be simultaneously addressed in a motivated situation, where a single scalar operator plays a dominant role, by the successful model parameters for the RK anomaly.

A new species of Physoctonus Mello-Leitão, 1934 from the 'Campos formations' of southern Amazonia (Scorpiones, Buthidae).

PubMed

Lourenço, Wilson R

2017-01-01

Further studies on new specimens of the rare genus Physoctonus Mello-Leitão, 1934, lead to the description of a third new species. Until now only Physoctonus debilis (C. L. Koch, 1840) and Physoctonus striatus Esposito et al., 2017, were known from sites located in the caatingas of the north-east region of Brazil. The new species of Physoctonus was collected by the French arachnologist J. Vellard in the Campos do Pará during his field trips back to the 1920/1930, and entrusted to the author in the early 1980s. The populations of P. debilis and P. striatus from north-east Brazil and that of the new species certainly present disrupted distributions. Biogeographical comments on this pattern of distribution are also added.

Dependence on radiation quality of DNA fragmentation spectra

NASA Astrophysics Data System (ADS)

Campa, Alessandro; Ottolenghi, Andrea; Alloni, Daniele; Ballarini, Francesca; Belli, Mauro; Esposito, Giuseppe; Facoetti, Angelica; Friedland, Werner; Liotta, Marco; Paretzke, Herwig

(Relative Biological Effectiveness) of high LET radiation. This work was partially supported by EU ("RISC-RAD" project, Contract no. FI6R-CT 2003- 508842, and "NOTE" project, Contract no. FI6R-036465) and ASI (Italian Space Agency, "Mo-Ma/COUNT" project). References A. Campa, F. Ballarini, M. Belli, R. Cherubini, V. Dini, G. Esposito, W.Friedland, S. Gerardi, S. Molinelli, A. Ottolenghi, H. G. Paretzke, G. Simone and M. A. Tabocchini. DNA DSB induced in human cells by charged particles and gamma rays: experimental results and theoretical approaches. Int. J. Radiat.Biol. 81, 841-854 (2005). D. Alloni, F. Ballarini, M. Belli, A. Campa, G. Esposito, W. Friedland, M.Liotta, A. Ottolenghi and H. G. Paretzke. Modeling of DNA fragmentation induced in human fibroblasts by 56 Fe ions. Adv. Space Res. 40, 1401-1407 (2007a). D. Alloni, F. Antonelli, F. Ballarini, M. Belli, A. Campa, V. Dini, G.Esposito, W. Friedland, M. Liotta, A. Ottolenghi, H. G. Paretzke, G. Simone, E. Sorrentino and M. A. Tabocchini. Small DNA fragments induced in human fibroblasts by 56 Fe ions: experimental data and MC simulations. Proc. "Ion Beams in biology and medicine", Heidelberg, 26-29 September 2007, edited by J. Debus, K. Henrichs, G. Kraft, p. 164 (2207b).

Reply to Comments on “AGU Statement: Investigation of Scientists and Officials in L'Aquila, Italy, Is Unfounded”

NASA Astrophysics Data System (ADS)

McPhaden, Michael

2010-10-01

It is critical to recognize the benefits and limitations of scientific knowledge, particularly when it comes to predicting hazards. I agree with G. J. Wasserburg that AGU should help scientists communicate their work accurately and understandably so it can provide the greatest value to society. This objective is explicit in AGU's new strategic plan (http://www.agu.org/about/strategic_plan.shtml) and is consistent with our vision of both advancing and communicating Earth and space science to ensure a sustainable future. We as a community have an obligation to increase the role of science in informing policy to mitigate the impacts of natural disasters. Such efforts require an open exchange of ideas and information and a clear understanding of the limitations of our knowledge. In response to Flavio Dobran, I agree that scientists are not above the law and, like all citizens, must be held accountable for their actions. However, laws and lawmakers must also recognize what science can and cannot do. We cannot yet reliably predict precisely when earthquakes will occur.

Accretion in Saturn's F Ring

NASA Astrophysics Data System (ADS)

Meinke, B. K.; Esposito, L. W.; Stewart, G.

2012-12-01

Saturn's F ring is the solar system's principal natural laboratory for direct observation of accretion and disruption processes. The ring resides in the Roche zone, where tidal disruption competes with self-gravity, which allows us to observe the lifecycle of moonlets. Just as nearby moons create structure at the B ring edge (Esposito et al. 2012) and the Keeler gap (Murray 2007), the F ring "shepherding" moons Prometheus and Pandora stir up ring material and create observably changing structures on timescales of days to decades. In fact, Beurle et al (2010) show that Prometheus makes it possible for "distended, yet gravitationally coherent clumps" to form in the F ring, and Barbara and Esposito (2002) predicted a population of ~1 km bodies in the ring. In addition to the observations over the last three decades, the Cassini Ultraviolet Imaging Spectrograph (UVIS) has detected 27 statistically significant features in 101 occultations by Saturn's F ring since July 2004. Seventeen of those 27 features are associated with clumps of ring material. Two features are opaque in occultation, which makes them candidates for solid objects, which we refer to as Moonlets. The 15 other features partially block stellar signal for 22 m to just over 3.7 km along the radial expanse of the occultation. Upon visual inspection of the occultation profile, these features resemble Icicles, thus we will refer to them as such here. The density enhancements responsible for such signal attenuations are likely due to transient clumping of material, evidence that aggregations of material are ubiquitous in the F ring. Our lengthy observing campaign reveals that Icicles are likely transient clumps, while Moonlets are possible solid objects. Optical depth is an indicator of clumping because more-densely aggregated material blocks more light; therefore, it is natural to imagine moonlets as later evolutionary stage of icicle, when looser clumps of material compact to form a feature that appears

Efficiency and its bounds for thermal engines at maximum power using Newton's law of cooling.

PubMed

Yan, H; Guo, Hao

2012-01-01

We study a thermal engine model for which Newton's cooling law is obeyed during heat transfer processes. The thermal efficiency and its bounds at maximum output power are derived and discussed. This model, though quite simple, can be applied not only to Carnot engines but also to four other types of engines. For the long thermal contact time limit, new bounds, tighter than what were known before, are obtained. In this case, this model can simulate Otto, Joule-Brayton, Diesel, and Atkinson engines. While in the short contact time limit, which corresponds to the Carnot cycle, the same efficiency bounds as that from Esposito et al. [Phys. Rev. Lett. 105, 150603 (2010)] are derived. In both cases, the thermal efficiency decreases as the ratio between the heat capacities of the working medium during heating and cooling stages increases. This might provide instructions for designing real engines. © 2012 American Physical Society

A cultural historical theoretical perspective of discourse and design in the science classroom

NASA Astrophysics Data System (ADS)

Adams, Megan

2015-06-01

Flavio Azevedo, Peggy Martalock and Tugba Keser have initiated an important conversation in science education as they use sociocultural theory to introduce design based scenarios into the science classroom. This response seeks to expand Azevedo, Martalock and Keser's article The discourse of design- based science classroom activities by using a specific perspective within a sociocultural framework. Through using a cultural historical (Vygotsky in The history and development of higher mental functions, Plenum Press, New York, 1987) reading of design based activity and discourse in the science classroom, it is proposed that learning should be an integral part of these processes. Therefore, everyday and scientific concepts are explained and expanded in relation to Inventing Graphing and discourse presented in Azevedo, Martalock and Keser's article. This response reports on the importance of teacher's being explicit in relation to connecting everyday and scientific concepts alongside design based activity and related science concepts when teaching students. It is argued that explicit teaching of concepts should be instigated prior to analysis of discourse in the science classroom as it is only with experience and understanding these processes that students have the resources to call upon to argue like practicing scientists.

Spontaneous Scalarization: Dead or Alive?

NASA Astrophysics Data System (ADS)

Berti, Emanuele; Crispino, Luis; Gerosa, Davide; Gualtieri, Leonardo; Horbatsch, Michael; Macedo, Caio; Okada da Silva, Hector; Pani, Paolo; Sotani, Hajime; Sperhake, Ulrich

2015-04-01

In 1993, Damour and Esposito-Farese showed that a wide class of scalar-tensor theories can pass weak-field gravitational tests and exhibit nonperturbative strong-field deviations away from General Relativity in systems involving neutron stars. These deviations are possible in the presence of ``spontaneous scalarization,'' a phase transition similar in nature to spontaneous magnetization in ferromagnets. More than twenty years after the original proposal, binary pulsar experiments have severely constrained the possibility of spontaneous scalarization occurring in nature. I will show that these experimental constraints have important implications for the torsional oscillation frequencies of neutron stars and for the so-called ``I-Love-Q'' relations in scalar-tensor theories. I will also argue that there is still hope to observe strong scalarization effects, despite the strong experimental bounds on the original mechanism. In particular, I will discuss two mechanisms that could produce strong scalarization in neutron stars: anisotropy and multiscalarization. This work was supported by NSF CAREER Award PHY-1055103.

Cord blood banking - bio-objects on the borderlands between community and immunity.

PubMed

Brown, Nik; Williams, Rosalind

2015-01-01

Umbilical cord blood (UCB) has become the focus of intense efforts to collect, screen and bank haematopoietic stem cells (HSCs) in hundreds of repositories around the world. UCB banking has developed through a broad spectrum of overlapping banking practices, sectors and institutional forms. Superficially at least, these sectors have been widely distinguished in bioethical and policy literature between notions of the 'public' and the 'private', the commons and the market respectively. Our purpose in this paper is to reflect more critically on these distinctions and to articulate the complex practical and hybrid nature of cord blood as a 'bio-object' that straddles binary conceptions of the blood economies. The paper draws upon Roberto Esposito's reflections on biopolitics and his attempt to transcend the dualistic polarisations of immunity and community, or the private and the public. We suggest that his thoughts on immunitary hospitality resonate with many of the actual features and realpolitik of a necessarily internationalised and globally distributed UCB 'immunitary regime'.

Microphysical Model Studies of Venus Clouds

NASA Astrophysics Data System (ADS)

Meade, P. E.; Bullock, M. A.; Grinspoon, D. H.

2004-11-01

We have adapted a standard cloud microphysics model to construct a self-consistent microphysical model of Venus' cloud layer which reproduces and extends previous studies (e.g. James et al. 1997). Our model is based on the Community Aerosol and Radiation Model Atmosphere (CARMA), which is a widely used computer code for terrestrial cloud microphysics, derived from the work of Toon et al. (1988). The standard code has been adapted to treat H2O and H2SO4 as co-condensing vapor species onto aqueous H2SO4 cloud droplets, as well as the nucleation of condensation nuclei to droplets. Vapor condensation and evaporation follows the method of James et al. (1997). Microphysical processes included in this model include nucleation of condensation nuclei, condensation and evaporation of H2O and H2SO4 vapor, and droplet coagulation. Vertical transport occurs though advection, eddy diffusion, sedimentation for both droplets and condensation nuclei. The cloud model is used to explore the sensitivity of Venus' cloud layer to environmental changes. Observations of the Venus' lower cloud from the Pioneer Venus, Venera, and Galileo spacecraft have suggested that the properties of the lower cloud may be time-variable, and at times may be entirely absent (Carlson et al. 1993, Grinspoon et al. 1993, Esposito et al. 1997). Our model explores the dependence of such behavior on environment factors such as variations in water or SO2 abundance. We have also calculated the optical properties of the model atmosphere using both the conventional optical constants for H2SO4 (Palmer and Williams, 1975), and the new data of Tisdale et al. (1998). This work has been supported by NASA's Exobiology Program. References Carlson, R.W., et al., 1993. Planetary and Space Science, 41, 477-486. Esposito, L.W., et al., 1997. In Venus II, eds. S.W. Bougher et al., pp. 415-458, University of Arizona Press, Tucson. Grinspoon, D.H., et al., 1993. Planetary and Space Science, 41 (July 1993), 515-542. James, E. P

UV Detection and Characterization of Plume Activity

NASA Astrophysics Data System (ADS)

Hansen, C. J.; Esposito, L. W.; Hendrix, A. R.

2017-12-01

Observations at ultraviolet wavelengths offer multiple techniques for detecting and characterizing plumes of gas erupting from planetary bodies. At Enceladus and Europa, UV observations include emission and absorption by water vapor molecules, and reflectance from ice particles. Emission: Emission features from electrons' interaction with water products H, OH, O and O2 can signal the presence of a plume. OH and O form a torus in the Saturn system, supplied by Enceladus' water vapor plume, that was detected before Cassini arrived in orbit [1, 2]. The nature of the ratio of H, O, and O2 emissions from Europa allow separation of the possible presence of plume(s) from Europa's O2 exosphere [3]. Absorption: The spectrum of starlight transmitted through an absorbing gas will have attenuation at UV wavelengths that are diagnostic of the composition of the gas. At Enceladus stellar and solar occultations by Enceladus' plume showed the primary composition to be water, constrained plume dimensions and revealed the presence of imbedded supersonic jets [4]. The amount of water coming from Enceladus and its variability over a decade has been measured [5]. Using Saturn as a source was not useful for Enceladus when it was observed in transit across Saturn. In contrast the putative detection of plume(s) at Europa has been bolstered by evidence that reflected light from Jupiter was being absorbed at particular places along Europa's limb as it transited Jupiter [6]. This contrast may reveal fundamental differences in the plumes at Europa and Enceladus [7]. Reflectance: With extremely long integration times the Enceladus plume has been observed reflecting light - light which is in turn absorbed by a small percentage of C2H4 gas being expelled [8]. The ice grain / gas ratio has been estimated by comparison of reflected light at near-IR wavelengths to the gas absorption of sunlight in the UV [9]. [1] Shemansky, D. E. et al. (1993) Nature 363:329; [2] Esposito, L. W. et al. (2005

Perezhivanie and classroom discourse: a cultural-historical perspective on "Discourse of design based science classroom activities"

NASA Astrophysics Data System (ADS)

Adams, Megan; March, Sue

2015-06-01

Flavio Azevedo, Peggy Martalock and Tugba Keser challenge the `argumentation focus of science lessons' and propose that through a `design-based approach' emergent conversations with the teacher offer possibilities for different types of discussions to enhance pedagogical discourse in science classrooms. This important paper offers a "preliminary contribution to a general theory" regarding the link between activity types and discourse practices. Azevedo, Martalock and Keser offer a general perspective with a sociocultural framing for analysis of classroom discourse. Interestingly the specific concepts drawn upon are from conversation analysis; there are few sociocultural concepts explored in detail. Therefore, in this article we focus on a cultural historical (Vygotsky in The collected works of L. S. Vygotsky. The history and development of higher mental functions, vol 4. Plenum Press, New York, 1987; The Vygotsky reader. Black, Cambridge, 1994) methodology to explore, analyse and explain how we would use a different theoretical lens. We argue that a cultural historical reading of argumentation in science lessons and design based activity will expand Azevedo, Martalock and Keser's proposed general theory of activity types and discourse practices. Specifically, we use Lev Vygotksy's idea of perezhivanie as the unit of analysis to reconceptualise this important paper. We focus on the holistic category of students' emotional experience through discourse while developing scientific awareness.

GPR Technologies and Methodologies in Italy: A Review

NASA Astrophysics Data System (ADS)

Benedetto, Andrea; Frezza, Fabrizio; Manacorda, Guido; Massa, Andrea; Pajewski, Lara

2014-05-01

GPR techniques and technologies have been subject of intense research activities at the Italian level in the last 15 years because of their potential applications specifically to civil engineering. More in detail, several innovative approaches and models have been developed to inspect road pavements to measure the thickness of their layers as well as to diagnose or prevent damage. Moreover, new frontiers in bridge inspection as well as in geotechnical applications such as slides and flows have been investigated using GPR. From the methodological viewpoint, innovative techniques have been developed to solve GPR forward-scattering problems, as well to locate and classify subsurface targets in real-time and to retrieve their properties through multi-resolution strategies, and linear and non-linear methodologies. Furthermore, the application of GPR and other non-destructive testing methods in archaeological prospecting, cultural heritage diagnostics, and in the localization and detection of vital signs of trapped people has been widely investigated. More recently, new theoretical and empirical paradigms regarding water moisture evaluation in various porous media and soil characterization have been published as the results of long terms research activities. Pioneer studies are also currently under development with the scope to correlate GPR measurement with mechanical characteristics of bound and unbound construction materials. In such a framework, this abstract will be aimed at reviewing some of the most recent advances of GPR techniques and technologies within the Italian industrial and academic communities [also including their application within international projects such as FP7 ISTIMES (http://www.istimes.eu)], and at envisaging some of the most promising research trends currently under development. Acknowledgment - This work was supported by COST Action TU1208 'Civil Engineering Applications of Ground Penetrating Radar' References [1] M. Balsi, S. Esposito, F

Optimal low symmetric dissipation Carnot engines and refrigerators

NASA Astrophysics Data System (ADS)

de Tomás, C.; Hernández, A. Calvo; Roco, J. M. M.

2012-01-01

A unified optimization criterion for Carnot engines and refrigerators is proposed. It consists of maximizing the product of the heat absorbed by the working system times the efficiency per unit time of the device, either the engine or the refrigerator. This criterion can be applied to both low symmetric dissipation Carnot engines and refrigerators. For engines the criterion coincides with the maximum power criterion and then the Curzon-Ahlborn efficiency ηCA=1-Tc/Th is recovered, where Th and Tc are the temperatures of the hot and cold reservoirs, respectively [Esposito, Kawai, Lindenberg, and Van den Broeck, Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.105.150603 105, 150603 (2010)]. For refrigerators the criterion provides the counterpart of Curzon-Ahlborn efficiency for refrigerators ɛCA=[1/(1-(Tc/Th)]-1, first derived by Yan and Chen for the particular case of an endoreversible Carnot-type refrigerator with linear (Newtonian) finite heat transfer laws [Yan and Chen, J. Phys. D: Appl. Phys.JPAPBE0022-372710.1088/0022-3727/23/2/002 23, 136 (1990)].

A model of late quaternary landscape development in the Delaware Valley, New Jersey and Pennsylvania

USGS Publications Warehouse

Ridge, J.C.; Evenson, E.B.; Sevon, W.D.

1992-01-01

In the Delaware Valley of New Jersey and eastern Pennsylvania the late Quaternary history of colluviation, fluvial adjustment, and soil formation is based on the ages of pre-Wisconsinan soils and glacial deposits which are indicated by feld relationships and inferred from mid-latitude climate changes indicated by marine oxygen-isotope records. The area is divided into four terranes characterized by sandstone, gneiss, slate and carbonate rocks. Since the last pre-Wisconsinan glaciation (> 130 ka, inferred to be late Illinoian), each terrane responded differently to chemical and mechanical weathering. During the Sangamon interglacial stage (??? 130-75 ka) in situ weathering is inferred to have occurred at rates greater than transportation of material which resulted in the formation of deep, highly weathered soil and saprolite, and dissolution of carbonate rocks. Cold climatic conditions during the Wisconsinan, on the other hand, induced erosion of the landscape at rates faster than soil development. Upland erosion during the Wisconsinan removed pre-Wisconsinan soil and glacial sediment and bedrock to produce muddy to blocky colluvium, gre??zes lite??es, and alluvial fans on footslopes. Fluvial gravel and overlying colluvium in the Delaware Valley, both buried by late Wisconsinan outwash, are inferred to represent episodes of early and middle Wisconsinan (??? 75-25 ka) upland erosion and river aggradiation followed by river degradation and colluvium deposition. Early-middle Wisconsinan colluvium is more voluminous than later colluvium despite colder, possibly permafrost conditions during the late Wisconsinan ??? 25-10 ka). Extensive colluviation during the early and middle Wisconsinan resulted from a longer (50 kyr), generally cold interval of erosion with a greater availability of easily eroded pre-Wisconsinan surficial materials on uplands than during the late Wisconsinan. After recession of late Wisconsinan ice from its terminal position, soil formation and

Weighted reciprocal of temperature, weighted thermal flux, and their applications in finite-time thermodynamics.

PubMed

Sheng, Shiqi; Tu, Z C

2014-01-01

The concepts of weighted reciprocal of temperature and weighted thermal flux are proposed for a heat engine operating between two heat baths and outputting mechanical work. With the aid of these two concepts, the generalized thermodynamic fluxes and forces can be expressed in a consistent way within the framework of irreversible thermodynamics. Then the efficiency at maximum power output for a heat engine, one of key topics in finite-time thermodynamics, is investigated on the basis of a generic model under the tight-coupling condition. The corresponding results have the same forms as those of low-dissipation heat engines [ M. Esposito, R. Kawai, K. Lindenberg and C. Van den Broeck Phys. Rev. Lett. 105 150603 (2010)]. The mappings from two kinds of typical heat engines, such as the low-dissipation heat engine and the Feynman ratchet, into the present generic model are constructed. The universal efficiency at maximum power output up to the quadratic order is found to be valid for a heat engine coupled symmetrically and tightly with two baths. The concepts of weighted reciprocal of temperature and weighted thermal flux are also transplanted to the optimization of refrigerators.

On the origin of south polar folds on Enceladus

NASA Astrophysics Data System (ADS)

Barr, Amy C.; Preuss, Lauren J.

2010-07-01

Recent high-resolution Cassini images of the south polar terrain of Enceladus reveal regions of short-wavelength deformation, inferred to be compressional folds between the Baghdad and Damascus tiger stripes (Spencer, J.R., Barr, A.C., Esposito, L.W., Helfenstein, P., Ingersoll, A.P., Jaumann, R., McKay, C.P., Nimmo, F., Waite, J.H. [2009a]. Enceladus: An active cryovolcanic satellite. In: Saturn after Cassini-Huygens. Springer, New York, pp. 683-722). Here, we use Fourier analysis of the bright/dark variations to show that the folds have a dominant wavelength of 1.1 ± 0.4 km. We use the simple model of lava flow folding from Fink (Fink, J. [1980]. Geology 8, 250-254) to show that the folds could form in an ice shell with an upper high-viscosity boundary layer of thickness <400 m, with a driving stress of 40-80 kPa, and strain rate between 10 -14 s -1 and 10 -12 s -1. Such deformation rates imply resurfacing of the SPT in 0.05-5 Myr, consistent with its estimated surface age. Measurements of fold topography and more sophisticated numerical modeling can narrow down the conditions of fold formation and provide valuable constraints on the thermal structure of the ice shell on Enceladus.

Does antibiotic prophylaxis at implant placement decrease early implant failures? A Cochrane systematic review.

PubMed

Esposito, Marco; Grusovin, Maria Gabriella; Loli, Vasiliki; Coulthard, Paul; Worthington, Helen V

2010-01-01

Marco Esposito is the first author of two of the included studies; however, he was not involved in the quality assessment of these trials. This review is based on a Cochrane systematic review entitled 'Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications' published in The Cochrane Library (see http://www.cochrane.org for more information). Cochrane systematic reviews are regularly updated to include new research, and in response to comments and criticisms from readers. If you wish to comment on this review, please send your comments to the Cochrane website or to Marco Esposito. The Cochrane Library should be consulted for the most recent version of the review. The results of a Cochrane Review can be interpreted differently, depending on people's perspectives and circumstances. Please consider the conclusions presented carefully. They are the opinions of the review authors, and are not necessarily shared by the Cochrane Collaboration. To assess the beneficial or harmful effects of systemic prophylactic antibiotics at dental implant placement versus no antibiotic/placebo administration and, if antibiotics are of benefit, to find which type, dosage and duration is the most effective. The Cochrane Oral Health Group's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE were searched up to 2 June 2010 for randomised controlled clinical trials (RCTs) with a follow-up of at least 3 months comparing the administration of various prophylactic antibiotic regimens versus no antibiotics to patients undergoing dental implant placement. Outcome measures were prosthesis failures, implant failures, postoperative infections and adverse events (gastrointestinal, hypersensitivity, etc.). Screening of eligible studies, assessment of the methodological quality of the trials and data extraction were conducted in duplicate and independently by two review authors. Meta-analyses were

Cyclin D1 down-regulation is essential for DBC2's tumor suppressor function

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoshihara, Takashi; Collado, Denise; Hamaguchi, Masaaki

2007-07-13

The expression of tumor suppressor gene DBC2 causes certain breast cancer cells to stop growing [M. Hamaguchi, J.L. Meth, C. Von Klitzing, W. Wei, D. Esposito, L. Rodgers, T. Walsh, P. Welcsh, M.C. King, M.H. Wigler, DBC2, a candidate for a tumor suppressor gene involved in breast cancer, Proc. Natl. Acad. Sci. USA 99 (2002) 13647-13652]. Recently, DBC2 was found to participate in diverse cellular functions such as protein transport, cytoskeleton regulation, apoptosis, and cell cycle control [V. Siripurapu, J.L. Meth, N. Kobayashi, M. Hamaguchi, DBC2 significantly influences cell cycle, apoptosis, cytoskeleton, and membrane trafficking pathways. J. Mol. Biol. 346more » (2005) 83-89]. Its tumor suppression mechanism, however, remains unclear. In this paper, we demonstrate that DBC2 suppresses breast cancer proliferation through down-regulation of Cyclin D1 (CCND1). Additionally, the constitutional overexpression of CCND1 prevented the negative impact of DBC2 expression on their growth. Under a CCND1 promoter, the expression of CCNE1 exhibited the same protective effect. Our results indicate that the down-regulation of CCND1 is an essential step for DBC2's growth suppression of cancer cells. We believe that this discovery contributes to a better understanding of DBC2's tumor suppressor function.« less

Prefazione al quarto volume di GERBERTVS

NASA Astrophysics Data System (ADS)

Sigismondi, Costantino

The fourth volume of GERBERTVS contains the acts of the symposia held in Rome, at the Odeion hall of Lettere faculty in Sapienza University on December 7, 2012 Gerbert Homo Novus and on March 13, 2013 on the pre and post humanistic figures. Laura C. Paladino presents the didactical activity of Gerbert as from Richer of Reims who completed his Historia Francorum in 998, before the election of Gerbert to the pontifical soil. Among these activities there is the teaching of astronomy and mathematics and the abacus, to which a special article of Jorge Nuno Silva is dedicated. The abacus increased dramatically the rapidity of the computations and some algoritms thaught by Gerbert and reported by his former student Bernelinus is very reliably invented by Gerbert himself, as Silva demostrates in his paper. Giancarlo Pani presents the relation between Galileo and Kepler, at the end of the humanistic period, showing interesting insights on the rather asymmetrical exchange of information between the two greater astronomer of 1600. Veronica Regoli presents the Cosmos of Dante, the ideal structure of the Divine Comedy. Patrick Demouy presents the new biography of Flavio G. Nuvolone where the great novelty is the noble origin of Gerbert from Carlat family, but before the marriage of his (presumed) father. His birth is shifted back to 938 with technical demostrations. Paolo Zanna compares the magisterium of Gerbert-Sylvester II and that one of John Paul II and pope Francesco. Finally C. Sigismondi presents the work and the activities of Pawel Max Maksym (1983-2013) who founded the Observatory &"Pope Sylvester II" in the town of Bukowiec, near Lodz, Poland.

A spontaneous tRNA suppressor of a mutation in the Chlamydomonas reinhardtii nuclear MCD1 gene required for stability of the chloroplast petD mRNA

PubMed Central

Murakami, Shinya; Kuehnle, Katrin; Stern, David B.

2005-01-01

Numerous nuclear gene products are required for the correct expression of organellar genes. One such gene in the green alga Chlamydomonas reinhardtii is MCD1, whose product is required for stability of the chloroplast-encoded petD mRNA. In mcd1 mutants, which are non-photosynthetic, petD mRNA is degraded by a 5′–3′ exonuclease activity, resulting in a failure to synthesize its product, subunit IV of the cytochrome b 6/f complex. Here, we report the sequence of the wild-type MCD1 gene, which encodes a large and novel putative protein. Analysis of three mutant alleles showed that two harbored large deletions, but that one allele, mcd1-2, had a single base change resulting in a nonsense codon near the N-terminus. This same mutant allele can be suppressed by a second-site mutation in the nuclear MCD2 gene, whereas mcd2-1 cannot suppress the deletion in mcd1-1 (Esposito,D. Higgs,D.C. Drager,R.G. Stern, D.B. and Girard-Bascou,J. (2001) Curr. Genet., 39, 40–48). We report the cloning of mcd2-1, and show that the mutation lies in a tRNASer(CGA), which has been modified to translate the nonsense codon in mcd1-2. We discuss how the existence of a large tRNASer gene family may permit this suppression without pleiotropic consequences. PMID:15947135

National aerospace meeting of the Institute of Navigation

NASA Astrophysics Data System (ADS)

Fell, Patrick

The program for this year's aerospace meeting of The Institute of Navigation addressed developments in the evolving Global Positioning System (GPS) of navigation satellites, inertial navigation systems, and other electronic navigation systems and their applications. Also included in the program were a limited number of papers addressing the geodetic use of the GPS system.The Global Positioning System is a constellation of 18 navigation satellites being developed by the Department of Defense to provide instantaneous worldwide navigation. The system will support a multitude of military applications. The first paper by Jacobson reviewed the engineering development of GPS navigation receivers stressing the use of common hardware and software modules. A later paper by Ould described the mechanization of a digital receiver for GPS applications designed for faster acquisition of the spread spectrum satellite transmissions than analog receivers. The paper by Brady discussed the worldwide coverage that is provided by the limited number of satellites that will constitute the GPS constellation through 1983. The capability provided by the satellites presently on orbit would support a variety of experiments at almost any location. Tables of multiple satellite availability are provided for numerous worldwide locations. For civil aviation applications, Vogel addressed the satellite geometry considerations for low cost GPS user equipment, Esposito described the Federal Aviation Administration acceptance tests of a GPS navigation receiver, and Hopkins discussed the design and capability of an integrated GPS strapdown attitude and heading reference system for avionics.

Constraints on Particle Sizes in Saturn's G Ring from Ring Plane Crossing Observations

NASA Astrophysics Data System (ADS)

Throop, H. B.; Esposito, L. W.

1996-09-01

The ring plane crossings in 1995--96 allowed earth-based observations of Saturn's diffuse rings (Nicholson et al., Nature 272, 1996; De Pater et al. Icarus 121, 1996) at a phase angle of alpha ~ 5 deg . We calculate the G ring reflectance for steady state distributions of dust to km-sized bodies from a range of physical models which track the evolution of the G ring from its initial formation following the disruption of a progenitor satellite (Canup & Esposito 1996, \\ Icarus,\\ in press). We model scattering from the ring's small particles using an exact T-matrix method for nonspherical, absorptive particles (Mishchenko et al. 1996, \\ JGR Atmo., in press), large particles using the phase function and spectrum of Europa, and intermediate particles using a linear combination of the small and large limits. Two distinct particle size distributions from the CE96 model fit the observed spectrum. The first is that of a dusty ring, with the majority of ring reflectance in dust particles of relatedly shallow power law size distribution exponent q ~ 2.5. The second has equal reflectances from a) dust in the range q ~ 3.5 -- 6.5 and b) macroscopic bodies > 1 mm. In this second case, the respective slightly blue and red components combine to form the observed relatively flat spectrum. Although light scattering in backscatter is not sufficient to completely constrain the G ring size distribution, the distributions predicted by the CE96 model can explain the earth-based observations.

Stochastic events may lead to accretion in Saturn's rings

NASA Astrophysics Data System (ADS)

Esposito, Larry W.

Stochastic events may lead to accretion in Saturn's rings Larry W. Esposito LASP, University of Colorado UVIS occultations indicate accretion is triggered at the B ring edge, in strong density waves in ring A and in the F ring. Moons may trigger accretion by streamline crowding (Lewis & Stewart); which enhances collisions, leading to accretion; increasing random velocities; leading to more collisions and more accretion. Cassini occultations of these strongly perturbed locations show not only accretion but also disaggregation, with time scales of hours to weeks. The collisions may lead to temporary aggregations via stochastic events: collisions can compress unconsolidated objects, trigger adhesion or bring small pieces into contact with larger or higher-density seeds. Disaggregation then can follow from disruptive collisions or tidal shedding. In the accretion/disruption balance, increased random motions could eventually give the upper hand to disruption. . . just as `irrational exuberance' can lead to financial panic in the economy; or the overpopulation of hares can lead to boom-and-bust in the population of foxes. I present a simple predator-prey model. This system's unstable equilibrium can similarly give rise to episodic cycles in accretion: explaining why the observable ring features that indicate embedded objects have been increasing since the beginning of Cassini's observations of Saturn in 2004. Unlike other interpretations of the peculiar events seen near Saturn Equinox, I emphasize the kinetic description of particle interactions rather than a fluid instability approach; and the dominance of stochastic events involving individual aggregates over free and/or driven modes in a flat disk.

Cosmological evolution and Solar System consistency of massive scalar-tensor gravity

NASA Astrophysics Data System (ADS)

de Pirey Saint Alby, Thibaut Arnoulx; Yunes, Nicolás

2017-09-01

The scalar-tensor theory of Damour and Esposito-Farèse recently gained some renewed interest because of its ability to suppress modifications to general relativity in the weak field, while introducing large corrections in the strong field of compact objects through a process called scalarization. A large sector of this theory that allows for scalarization, however, has been shown to be in conflict with Solar System observations when accounting for the cosmological evolution of the scalar field. We here study an extension of this theory by endowing the scalar field with a mass to determine whether this allows the theory to pass Solar System constraints upon cosmological evolution for a larger sector of coupling parameter space. We show that the cosmological scalar field goes first through a quiescent phase, similar to the behavior of a massless field, but then it enters an oscillatory phase, with an amplitude (and frequency) that decays (and grows) exponentially. We further show that after the field enters the oscillatory phase, its effective energy density and pressure are approximately those of dust, as expected from previous cosmological studies. Due to these oscillations, we show that the scalar field cannot be treated as static today on astrophysical scales, and so we use time-dependent perturbation theory to compute the scalar-field-induced modifications to Solar System observables. We find that these modifications are suppressed when the mass of the scalar field and the coupling parameter of the theory are in a wide range, allowing the theory to pass Solar System constraints, while in principle possibly still allowing for scalarization.

Analyzing Bleriot's propeller gaps in Cassini NAC images

NASA Astrophysics Data System (ADS)

Hoffmann, Holger; Chen, Cheng; Seiß, Martin; Albers, Nicole; Spahn, Frank; Nic

2016-10-01

Among the great discoveries of the Cassini mission are the propeller-shaped structures created by small moonlets embedded in Saturn's dense rings. These moonlets are not massive enough to counteract the viscous ring diffusion to open and maintain circumferential gaps, distinguishing them from ring-moons like Pan and Daphnis.Although one of the defining features of propeller structures, well-formed partial gaps have been resolved by the Imaging Science Subsystem Narrow Angle Camera onboard the Cassini spacecraft only for the largest known propeller named Bleriot. We analyze images of the sunlit side of Saturn's outer A ring showing the propeller Bleriot with clearly visible gaps. By fitting a Gaussian to radial brightness profiles at different azimuthal locations, we obtain the evolution of gap minimum and gap width downstream of the moonlet.We report two findings:1) Numerical simulations indicate that the radial separation of the partial propeller gaps is expected to be 4 Hill radii (Spahn and Sremcevic, 2000, A&A). We infer Bleriot's Hill radius to be a few hundred meters, consistent with values given by Sremcevic et al. (2014, DPS) and Hoffmann et al. (2015, Icarus).2) In order to estimate the ring viscosity in the region of Saturn's outer A ring, where Bleriot orbits, we fit several model functions (one example being the analytic solution derived by Sremcevic, Spahn and Duschl, 2002, MNRAS) describing the azimuthal evolution of the surface density in the propeller gap region to the data obtained from the image analysis. We find viscosity values consistent with the parameterization of ring viscosity by Daisaka et al. (2001, Icarus), but significantly lower than the upper limit given by Esposito et al. (1983, Icarus)

Spatio-temporal Dynamics of Audiovisual Speech Processing

PubMed Central

Bernstein, Lynne E.; Auer, Edward T.; Wagner, Michael; Ponton, Curtis W.

2007-01-01

The cortical processing of auditory-alone, visual-alone, and audiovisual speech information is temporally and spatially distributed, and functional magnetic resonance imaging (fMRI) cannot adequately resolve its temporal dynamics. In order to investigate a hypothesized spatio-temporal organization for audiovisual speech processing circuits, event-related potentials (ERPs) were recorded using electroencephalography (EEG). Stimuli were congruent audiovisual /bα/, incongruent auditory /bα/ synchronized with visual /gα/, auditory-only /bα/, and visual-only /bα/ and /gα/. Current density reconstructions (CDRs) of the ERP data were computed across the latency interval of 50-250 milliseconds. The CDRs demonstrated complex spatio-temporal activation patterns that differed across stimulus conditions. The hypothesized circuit that was investigated here comprised initial integration of audiovisual speech by the middle superior temporal sulcus (STS), followed by recruitment of the intraparietal sulcus (IPS), followed by activation of Broca's area (Miller and d'Esposito, 2005). The importance of spatio-temporally sensitive measures in evaluating processing pathways was demonstrated. Results showed, strikingly, early (< 100 msec) and simultaneous activations in areas of the supramarginal and angular gyrus (SMG/AG), the IPS, the inferior frontal gyrus, and the dorsolateral prefrontal cortex. Also, emergent left hemisphere SMG/AG activation, not predicted based on the unisensory stimulus conditions was observed at approximately 160 to 220 msec. The STS was neither the earliest nor most prominent activation site, although it is frequently considered the sine qua non of audiovisual speech integration. As discussed here, the relatively late activity of the SMG/AG solely under audiovisual conditions is a possible candidate audiovisual speech integration response. PMID:17920933

Anabolic effect of plant brassinosteroid

PubMed Central

Esposito, Debora; Komarnytsky, Slavko; Shapses, Sue; Raskin, Ilya

2011-01-01

Brassinosteroids are plant-derived polyhydroxylated derivatives of 5a-cholestane, structurally similar to cholesterol-derived animal steroid hormones and insect ecdysteroids, with no known function in mammals. 28-Homobrassinolide (HB), a steroidal lactone with potent plant growth-promoting property, stimulated protein synthesis and inhibited protein degradation in L6 rat skeletal muscle cells (EC50 4 μM) mediated in part by PI3K/Akt signaling pathway. Oral administration of HB (20 or 60 mg/kg/d for 24 d) to healthy rats fed normal diet (protein content 23.9%) increased food intake, body weight gain, lean body mass, and gastrocnemius muscle mass as compared with vehicle-treated controls. The effect of HB administration increased slightly in animals fed a high-protein diet (protein content 39.4%). Both oral (up to 60 mg/kg) and subcutaneous (up to 4 mg/kg) administration of HB showed low androgenic activity when tested in the Hershberger assay. Moreover, HB showed no direct binding to the androgen receptor in vitro. HB treatment was also associated with an improved physical fitness of untrained healthy rats, as evident from a 6.7% increase in lower extremity strength, measured by grip test. In the gastrocnemius muscle of castrated animals, HB treatment significantly increased the number of type IIa and IIb fibers and the cross-sectional area of type I and type IIa fibers. These findings suggest that oral application of HB triggers selective anabolic response with minimal or no androgenic side-effects and begin to elucidate the putative cellular targets for plant brassinosteroids in mammals.—Esposito, D., Komarnytsky, S., Shapses, S., Raskin, I. Anabolic effect of plant brassinosteroid. PMID:21746867

Efficiency at maximum power output of linear irreversible Carnot-like heat engines.

PubMed

Wang, Yang; Tu, Z C

2012-01-01

The efficiency at maximum power output of linear irreversible Carnot-like heat engines is investigated based on the assumption that the rate of irreversible entropy production of the working substance in each "isothermal" process is a quadratic form of the heat exchange rate between the working substance and the reservoir. It is found that the maximum power output corresponds to minimizing the irreversible entropy production in two isothermal processes of the Carnot-like cycle, and that the efficiency at maximum power output has the form η(mP)=η(C)/(2-γη(C)), where η(C) is the Carnot efficiency, while γ depends on the heat transfer coefficients between the working substance and two reservoirs. The value of η(mP) is bounded between η(-)≡η(C)/2 and η(+)≡η(C)/(2-η(C)). These results are consistent with those obtained by Chen and Yan [J. Chem. Phys. 90, 3740 (1989)] based on the endoreversible assumption, those obtained by Esposito et al. [Phys. Rev. Lett. 105, 150603 (2010)] based on the low-dissipation assumption, and those obtained by Schmiedl and Seifert [Europhys. Lett. 81, 20003 (2008)] for stochastic heat engines which in fact also satisfy the low-dissipation assumption. Additionally, we find that the endoreversible assumption happens to hold for Carnot-like heat engines operating at the maximum power output based on our fundamental assumption, and that the Carnot-like heat engines that we focused on do not strictly satisfy the low-dissipation assumption, which implies that the low-dissipation assumption or our fundamental assumption is a sufficient but non-necessary condition for the validity of η(mP)=η(C)/(2-γη(C)) as well as the existence of two bounds, η(-)≡η(C)/2 and η(+)≡η(C)/(2-η(C)). © 2012 American Physical Society

Evidence for a Functional Hierarchy of Association Networks.

PubMed

Choi, Eun Young; Drayna, Garrett K; Badre, David

2018-05-01

Patient lesion and neuroimaging studies have identified a rostral-to-caudal functional gradient in the lateral frontal cortex (LFC) corresponding to higher-order (complex or abstract) to lower-order (simple or concrete) cognitive control. At the same time, monkey anatomical and human functional connectivity studies show that frontal regions are reciprocally connected with parietal and temporal regions, forming parallel and distributed association networks. Here, we investigated the link between the functional gradient of LFC regions observed during control tasks and the parallel, distributed organization of association networks. Whole-brain fMRI task activity corresponding to four orders of hierarchical control [Badre, D., & D'Esposito, M. Functional magnetic resonance imaging evidence for a hierarchical organization of the prefrontal cortex. Journal of Cognitive Neuroscience, 19, 2082-2099, 2007] was compared with a resting-state functional connectivity MRI estimate of cortical networks [Yeo, B. T., Krienen, F. M., Sepulcre, J., Sabuncu, M. R., Lashkari, D., Hollinshead, M., et al. The organization of the human cerebral cortex estimated by intrinsic functional connectivity. Journal of Neurophysiology, 106, 1125-1165, 2011]. Critically, at each order of control, activity in the LFC and parietal cortex overlapped onto a common association network that differed between orders. These results are consistent with a functional organization based on separable association networks that are recruited during hierarchical control. Furthermore, corticostriatal functional connectivity MRI showed that, consistent with their participation in functional networks, rostral-to-caudal LFC and caudal-to-rostral parietal regions had similar, order-specific corticostriatal connectivity that agreed with a striatal gating model of hierarchical rule use. Our results indicate that hierarchical cognitive control is subserved by parallel and distributed association networks, together forming

Constraining Nonperturbative Strong-Field Effects in Scalar-Tensor Gravity by Combining Pulsar Timing and Laser-Interferometer Gravitational-Wave Detectors

NASA Astrophysics Data System (ADS)

Shao, Lijing; Sennett, Noah; Buonanno, Alessandra; Kramer, Michael; Wex, Norbert

2017-10-01

Pulsar timing and laser-interferometer gravitational-wave (GW) detectors are superb laboratories to study gravity theories in the strong-field regime. Here, we combine these tools to test the mono-scalar-tensor theory of Damour and Esposito-Farèse (DEF), which predicts nonperturbative scalarization phenomena for neutron stars (NSs). First, applying Markov-chain Monte Carlo techniques, we use the absence of dipolar radiation in the pulsar-timing observations of five binary systems composed of a NS and a white dwarf, and eleven equations of state (EOSs) for NSs, to derive the most stringent constraints on the two free parameters of the DEF scalar-tensor theory. Since the binary-pulsar bounds depend on the NS mass and the EOS, we find that current pulsar-timing observations leave scalarization windows, i.e., regions of parameter space where scalarization can still be prominent. Then, we investigate if these scalarization windows could be closed and if pulsar-timing constraints could be improved by laser-interferometer GW detectors, when spontaneous (or dynamical) scalarization sets in during the early (or late) stages of a binary NS (BNS) evolution. For the early inspiral of a BNS carrying constant scalar charge, we employ a Fisher-matrix analysis to show that Advanced LIGO can improve pulsar-timing constraints for some EOSs, and next-generation detectors, such as the Cosmic Explorer and Einstein Telescope, will be able to improve those bounds for all eleven EOSs. Using the late inspiral of a BNS, we estimate that for some of the EOSs under consideration, the onset of dynamical scalarization can happen early enough to improve the constraints on the DEF parameters obtained by combining the five binary pulsars. Thus, in the near future, the complementarity of pulsar timing and direct observations of GWs on the ground will be extremely valuable in probing gravity theories in the strong-field regime.

Gamma-Ray Observations of Supernova Remnants

NASA Astrophysics Data System (ADS)

Buckley, James

2000-04-01

Despite the growing evidence for shock acceleration of electrons in supernova remnants (SNR), there is still no direct evidence pointing unambiguously to SNR as sources of cosmic-ray nuclei. Observations of nonthermal synchrotron emission in the limbs of a number of shell-type SNR (SN1006, Tycho, Cas A, IC443, RCW86, and Kepler) provide convincing evidence for acceleration of electrons to energies greater than 10 TeV (Allen 1999). The CANGAROO group has now reported significant VHE gamma-ray emission from SN1006 (Tanimori et al. 1998) and RXJ1713-3946, and the HEGRA group has reported preliminary evidence for TeV emission from Cas A (Pülhofer et al. 1999); all of these measurements are consistent with the expected level of inverse-Compton emission in these objects. Following the predictions of an observable π^0-decay signal from nearby SNRs (e.g., Drury, Aharonian and Volk 1994) the discovery of >100 MeV emission from the direction of a number of SNR by the EGRET experiment (Esposito et al. 1996) and possible evidence for a π^0 component (Gaisser, Protheroe and Stanev 1996) led to some initial optimism that evidence for a SNR origin of cosmic-ray nuclei had been obtained. However, 200 GeV to 100 TeV measurements revealed no significant emission implying either a significantly steeper source spectrum than the canonical ~ E-2.1, a spectral cutoff below the knee energy in these sources, or that a re-interpretation of the EGRET results was required. I will discuss these results, as well as the considerable promise of future gamma-ray experiments to determine the sources of galactic cosmic-ray nuclei and to provide quantitative information about the acceleration mechanisms.

PREFACE: Workshop Photograph and Program

NASA Astrophysics Data System (ADS)

2011-07-01

Workshop photograph Workshop Program Sunday 28 March 201019:00-21:00 Reception at Okura Frontier Hotel Tsukuba(Buffet style dinner with drink) Monday 29 March 2010Introduction (Chair: André Rubbia (ETH Zurich))09:00 Welcome address (05') Atsuto Suzuki (KEK)09:05 Message from CERN on neutrino physics (10') Sergio Bertolucci (CERN)09:15 Message from FNAL on neutrino physics (10') Young Kee Kim (FNAL)09:25 Message from KEK on neutrino physics (10') Koichiro Nishikawa (KEK)09:35 Introductory remark on GLA2010 (10') Takuya Hasegawa (KEK) Special session (Chair: Koichiro Nishikawa (KEK))09:45 The ICARUS Liquid Argon TPC (45') Carlo Rubbia (CERN)10:30-11:00 Coffee break Main goals of Giant Liquid Argon Charge Imaging Experiments I (Chair: Takashi Kobayashi (KEK))11:00 Results from massive underground detectors (non accelerator) (30') Takaaki Kajita (ICRR, U. of Tokyo)11:30 Present long baseline neutrino experiments (30') Chang Kee Jung (SUNY Stony Brook)12:00-12:10 Workshop picture12:10-14:00 Lunch break Main goals of Giant Liquid Argon Charge Imaging Experiments II (Chair: Takashi Kobayashi (KEK))14:00 Physics goals of the next generation massive underground experiments (30') David Wark (Imperial College London)14:30 Near detectors for long baseline neutrino experiments (20') Tsuyoshi Nakaya (Kyoto U.) Lessons on Liquid Argon Charge Imaging technology from ongoing developments (Chair: Chang Kee Jung (SUNY Stony Brook))14:50 WARP (30') Claudio Montanari (U. of Pavia)15:20 ArDM (30') Alberto Marchionni (ETH Zurich)15:50 From ArgoNeuT to MicroBooNE (30') Bonnie Fleming (Yale U.)16:20 250L (30') Takasumi Maruyama (KEK)16:50 The DEAP/CLEAN project (20') Mark Boulay (Queen's U.)17:10-17:40 Coffee break Lessons from Xe based Liquids Imaging detectors (Chair: Flavio Cavanna (U. of L'Aquilla))17:30 MEG (20') Satoshi Mihara (KEK)17:50 The XENON project (20') Elena Aprile (Columbia U.)18:10 XMASS (20') Hiroyuki Sekiya (ICRR, U. of Tokyo) Studies on physics performance (Chair

Confirmation of a traveling feature in Saturn's rings in Cassini Imaging Science Subsystem data

NASA Astrophysics Data System (ADS)

Aye, K. M.; Rehnberg, M.; Esposito, L. W.

2017-12-01

Introduction: Using Cassini UVIS occultation data, a traveling wave feature has been identified in the Saturn rings that is most likely caused by the radial positions swap of the moons Janus and Epimetheus [1]. The hypothesis is that non-linear interferences between the density waves when being relocated by the moon swap create a solitary wave that is traveling outward through the rings. The observations in [1] further lead to the derivation of values for the radial travel speeds of the identified traveling features, from 39.6 km/yr for the Janus 5:4 resonance up to 45.8 for the Janus 4:3 resonance. Previous confirmations in ISS data: Work in [1] also identified the feature in Cassini Imaging Science Subsystem (ISS) data that was taken around the time of the UVIS occultations where the phenomenon was first discovered, so far one ISS image for each Janus resonances 2:1, 4:3, 5:4, and 6:5. Searches performed in ISS data: Filtering all existing ISS data down to the best resolutions that include both a clearly identifiable minimum and maximum ring radius, we have visually inspected approx. 200 images, both with and without known resonances within the image, but unbeknownst to the inspector. Identification of a feature of interest happens when train waves are being interrupted by anomalies. Comparing the radial locations of identified ISS features with those in UV data of [1], we have identified several at the same radii. Considering the vast differences in radial resolution, we conclude that the traveling feature causes observable anomalies at both small scales of meters, up to large scales of hundreds of meters to kilometers.References: [1] Rehnberg, M.E., Esposito, L.W., Brown, Z.L., Albers, N., Sremčević, M., Stewart, G.R., 2016. A Traveling Feature in Saturn's Rings. Icarus, accepted in June 2016. [2] K.-Michael Aye (2016, November 11). michaelaye/pyciss: . v0.6.0 Zenodo. https://doi.org/10.5281/zenodo.596802

Efficiency at maximum power output of linear irreversible Carnot-like heat engines

NASA Astrophysics Data System (ADS)

Wang, Yang; Tu, Z. C.

2012-01-01

The efficiency at maximum power output of linear irreversible Carnot-like heat engines is investigated based on the assumption that the rate of irreversible entropy production of the working substance in each “isothermal” process is a quadratic form of the heat exchange rate between the working substance and the reservoir. It is found that the maximum power output corresponds to minimizing the irreversible entropy production in two isothermal processes of the Carnot-like cycle, and that the efficiency at maximum power output has the form ηmP=ηC/(2-γηC), where ηC is the Carnot efficiency, while γ depends on the heat transfer coefficients between the working substance and two reservoirs. The value of ηmP is bounded between η-≡ηC/2 and η+≡ηC/(2-ηC). These results are consistent with those obtained by Chen and Yan [J. Chem. Phys.JCPSA60021-960610.1063/1.455832 90, 3740 (1989)] based on the endoreversible assumption, those obtained by Esposito [Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.105.150603 105, 150603 (2010)] based on the low-dissipation assumption, and those obtained by Schmiedl and Seifert [Europhys. Lett.EULEEJ0295-507510.1209/0295-5075/81/20003 81, 20003 (2008)] for stochastic heat engines which in fact also satisfy the low-dissipation assumption. Additionally, we find that the endoreversible assumption happens to hold for Carnot-like heat engines operating at the maximum power output based on our fundamental assumption, and that the Carnot-like heat engines that we focused on do not strictly satisfy the low-dissipation assumption, which implies that the low-dissipation assumption or our fundamental assumption is a sufficient but non-necessary condition for the validity of ηmP=ηC/(2-γηC) as well as the existence of two bounds, η-≡ηC/2 and η+≡ηC/(2-ηC).

Temperature-induced conformational change at the catalytic site of Sulfolobus solfataricus alcohol dehydrogenase highlighted by Asn249Tyr substitution. A hydrogen/deuterium exchange, kinetic, and fluorescence quenching study.

PubMed

Secundo, Francesco; Russo, Consiglia; Giordano, Antonietta; Carrea, Giacomo; Rossi, Mosè; Raia, Carlo A

2005-08-23

A combination of hydrogen/deuterium exchange, fluorescence quenching, and kinetic studies was used to acquire experimental evidence for the crystallographically hypothesized increase in local flexibility which occurs in thermophilic NAD(+)-dependent Sulfolobus solfataricus alcohol dehydrogenase (SsADH) upon substitution Asn249Tyr. The substitution, located at the adenine-binding site, proved to decrease the affinity for both coenzyme and substrate, rendering the mutant enzyme 6-fold more active when compared to the wild-type enzyme [Esposito et al. (2003) FEBS Lett. 539, 14-18]. The amide H/D exchange data show that the wild-type and mutant enzymes have similar global flexibility at 22 and 60 degrees C. However, the temperature dependence of the Stern-Volmer constant determined by acrylamide quenching shows that the increase in temperature affects the local flexibility differently, since the K(SV) increment is significantly higher for the wild-type than for the mutant enzyme over the range 18-45 degrees C. Interestingly, the corresponding van't Hoff plot (log K(SV) vs 1/T) proves nonlinear for the apo and holo wild-type and apo mutant enzymes, with a break at approximately 45 degrees C in all three cases due to a conformational change affecting the tryptophan microenvironment experienced by the quencher molecules. The Arrhenius and van't Hoff plots derived from the k(cat) and K(M) thermodependence measured with cyclohexanol and NAD(+) at different temperatures display an abrupt change of slope at 45-50 degrees C. This proves more pronounced in the case of the mutant enzyme compared to the wild-type enzyme due to a conformational change in the structure rather than to an overlapping of two or more rate-limiting reaction steps with different temperature dependencies of their rate constants. Three-dimensional analysis indicates that the observed conformational change induced by temperature is associated with the flexible loops directly involved in the substrate and

Specific Adaptations in Performance and Muscle Architecture After Weighted Jump-Squat vs. Body Mass Squat Jump Training in Recreational Soccer Players.

PubMed

Coratella, Giuseppe; Beato, Marco; Milanese, Chiara; Longo, Stefano; Limonta, Eloisa; Rampichini, Susanna; Cè, Emiliano; Bisconti, Angela V; Schena, Federico; Esposito, Fabio

2018-04-01

Coratella, G, Beato, M, Milanese, C, Longo, S, Limonta, E, Rampichini, S, Cè, E, Bisconti, AV, Schena, F, and Esposito, F. Specific adaptations in performance and muscle architecture after weighted jump-squat vs. body mass squat jump training in recreational soccer players. J Strength Cond Res 32(4): 921-929, 2018-The aim of the present study was to compare the effects of weighted jump-squat training (WJST) vs. body mass squat jump training (BMSJT) on quadriceps' muscle architecture, lower-limb lean-mass (LM) and muscle strength, performance in change of direction (COD), and sprint and jump in recreational soccer players. Forty-eight healthy soccer players participated in an offseason randomized controlled trial. Before and after an 8-week training intervention, vastus lateralis pennation angle, fascicle length, muscle thickness, LM, squat 1RM, quadriceps and hamstrings isokinetic peak torque, agility T-test, 10-and 30-m sprints, and squat-jump (SJ) were measured. Although similar increases were observed in muscle thickness, fascicle length increased more in WJST (Effect size [ES] = 1.18, 0.82-1.54) than in BMSJT (ES = 0.54, 0.40-0.68), and pennation angle increased only in BMSJT (ES = 1.03, 0.78-1.29). Greater increases in LM were observed in WJST (ES = 0.44, 0.29-0.59) than in BMSJT (ES = 0.21, 0.07-0.37). The agility T-test (ES = 2.95, 2.72-3.18), 10-m (ES = 0.52, 0.22-0.82), and 30-m sprints (ES = 0.52, 0.23-0.81) improved only in WJST, whereas SJ improved in BMSJT (ES = 0.89, 0.43-1.35) more than in WJST (ES = 0.30, 0.03-0.58). Similar increases in squat 1RM and peak torque occurred in both groups. The greater inertia accumulated within the landing phase in WJST vs. BMSJT has increased the eccentric workload, leading to specific eccentric-like adaptations in muscle architecture. The selective improvements in COD in WJST may be related to the increased braking ability generated by the enhanced eccentric workload.

The Peculiar Electrical Properties of the 8-12th September, 2015 Massive Dust Outbreak Over the Levant

NASA Astrophysics Data System (ADS)

Yair, Y.; Katz, S.; Price, C.; Ziv, B.; Yaniv, R.

2016-12-01

Dust storms over the Levant and Eastern Mediterranean region are common and occur several times a year, depending on synoptic systems and meteorological parameters. Such storms are often accompanied by large electrical charging, most likely due to triboelectric processes (Esposito et al., 2016). The effects of dust storms on atmospheric electricity parameters such as the fair weather electric field (Ez) and current density (Jz) are well documented, but have not been extensively studied for the Levant region. We report new measurements conducted during the massive dust outbreak that occurred over the region in September 08-12, 2015. That event was one of the strongest dust storms on record and engulfed the entire region for 5 consecutive days, from Iraq through Syria, Jordan, Israel, Lebanon, the Eastern Mediterranean Sea, Cyprus and Egypt. Ground-based measurements of Ez and Jz were conducted at the Wise Observatory (WO) in Mizpe-Ramon (30035'N, 34045'E) and at Mt. Hermon (30024'N, 35051'E). The Aerosol Optical Thickness (AOT) obtained from the AERONET station in Sde-Boker reached values up to 4.0. During the dust outbreak very large fluctuations in the electrical parameters were measured at both stations, however remarkable differences were noted. While at the Mt. Hermon station we registered strong positive values of the electric field and current density, the values registered at WO were significantly smaller and more negative. The Mt. Hermon site showed Ez and Jz values fluctuating between -460 and +570 V m-1 and -14.5 and +18 pA m-2 respectively. In contrast, Ez values registered at WO were between -430 and +10 V m-1, while the Jz fluctuated between -6 and +3 pA m-2 .When compared with the February 2015 electrified dust storm reported by Yair et al. (2016), we note substantial differences in the electric parameters variability, amplitude and polarity. The possible reasons for these differences will be discussed.

Searching for a traveling feature in Saturn's rings in Cassini Imaging Science Subsystem data

NASA Astrophysics Data System (ADS)

Aye, Klaus-Michael; Rehnberg, Morgan; Brown, Zarah; Esposito, Larry W.

2016-10-01

Introduction: Using Cassini UVIS occultation data, a traveling wave feature has been identified in the Saturn rings that is most likely caused by the radial positions swap of the moons Janus and Epimetheus [1]. The hypothesis is that non-linear interferences between the linear density waves when being relocated by the moon swap create a solitary wave that is traveling outward through the rings. The observations in [1] further lead to the derivation of values for the radial travel speeds of the identified traveling features, from 39.6 km/yr for the Janus 5:4 resonance up to 45.8 for the Janus 4:3 resonance.Previous confirmations in ISS data: Work in [1] also identified the feature in Cassini Imaging Science Subsystem (ISS) data that was taken around the time of the UVIS occultations where the phenomenon was first discovered, so far one ISS image for each Janus resonances 2:1, 4:3, 5:4, and 6:5.Search guided by predicted locations: Using the observation-fitted radial velocities from [1], we can extrapolate these to identify Saturn radii at which the traveling feature should be found at later times. Using this and new image analysis and plotting tools available in [2], we have identified a potential candidate feature in an ISS image that was taken 2.5 years after the feature causing moon swap in January 2006. We intend to expand our search by identifying candidate ISS data by a meta-database search constraining the radius at future times corresponding to the predicted future locations of the hypothesized solitary wave and present our findings at this conference.References: [1] Rehnberg, M.E., Esposito, L.W., Brown, Z.L., Albers, N., Sremčević, M., Stewart, G.R., 2016. A Traveling Feature in Saturn's Rings. Icarus, accepted in June 2016. [2] K.-Michael Aye. (2016). pyciss: v0.5.0. Zenodo. 10.5281/zenodo.53092

Structural basis for the glycosyltransferase activity of the Salmonella effector SseK3.

PubMed

Esposito, Diego; Günster, Regina A; Martino, Luigi; El Omari, Kamel; Wagner, Armin; Thurston, Teresa L M; Rittinger, Katrin

2018-04-06

The Salmonella -secreted effector SseK3 translocates into host cells, targeting innate immune responses, including NF-κB activation. SseK3 is a glycosyltransferase that transfers an N -acetylglucosamine (GlcNAc) moiety onto the guanidino group of a target arginine, modulating host cell function. However, a lack of structural information has precluded elucidation of the molecular mechanisms in arginine and GlcNAc selection. We report here the crystal structure of SseK3 in its apo form and in complex with hydrolyzed UDP-GlcNAc. SseK3 possesses the typical glycosyltransferase type-A (GT-A)-family fold and the metal-coordinating D X D motif essential for ligand binding and enzymatic activity. Several conserved residues were essential for arginine GlcNAcylation and SseK3-mediated inhibition of NF-κB activation. Isothermal titration calorimetry revealed SseK3's preference for manganese coordination. The pattern of interactions in the substrate-bound SseK3 structure explained the selection of the primary ligand. Structural rearrangement of the C-terminal residues upon ligand binding was crucial for SseK3's catalytic activity, and NMR analysis indicated that SseK3 has limited UDP-GlcNAc hydrolysis activity. The release of free N -acetyl α-d-glucosamine, and the presence of the same molecule in the SseK3 active site, classified it as a retaining glycosyltransferase. A glutamate residue in the active site suggested a double-inversion mechanism for the arginine N -glycosylation reaction. Homology models of SseK1, SseK2, and the Escherichia coli orthologue NleB1 reveal differences in the surface electrostatic charge distribution, possibly accounting for their diverse activities. This first structure of a retaining GT-A arginine N -glycosyltransferase provides an important step toward a better understanding of this enzyme class and their roles as bacterial effectors. © 2018 Esposito et al.

C-O-H-S magmatic fluid system in shrinkage bubbles of melt inclusions

NASA Astrophysics Data System (ADS)

Robidoux, P.; Frezzotti, M. L.; Hauri, E. H.; Aiuppa, A.

2016-12-01

Magmatic volatiles include multiple phases in the C-O-H-S system of shrinkage bubbles for which a conceptual model is still unclear during melt inclusion formation [1,2,3,4]. The present study aims to qualitatively explore the evolution of the volatile migration, during and after the formation of the shrinkage bubble in melt inclusions trapped by olivines from Holocene to present at San Cristóbal volcano (Nicaragua), Central American Volcanic Arc (CAVA). Combined scanning electron microscope (SEM) and Raman spectroscopy observations allow to define the mineral-fluid phases inside typical shrinkage bubbles at ambient temperature. The existence of residual liquid water is demonstrated in the shrinkage bubbles of naturally quenched melt inclusion and this water could represents the principal agent for chemical reactions with other dissolved ionic species (SO42-, CO32-, etc.) and major elements (Mg, Fe, Cu, etc.) [4,5]. With the objective of following the cooling story of the bubble-inclusion system, the new methodological approach here estimate the interval of equilibrium temperatures for each SEM-Raman identified mineral phase (carbonates, hydrous carbonates, sulfurs, sulfates, etc.). Finally, two distinct mechanisms are proposed to describe the evolution of this heterogeneous fluid system in bubble samples at San Cristóbal which imply a close re-examination for similar volcanoes in subduction zone settings: (1) bubbles are already contracted and filled by volatiles by diffusion processes from the glass and leading to a C-O-H-S fluid-glass reaction enriched in Mg-Fe-Cu elements (2) bubbles are formed by oversaturation of the volatiles from the magma which is producing an immiscible metal-rich fluid. [1]Moore et al. (2015). Am. Mineral. 100, 806-823 [2]Wallace et al. (2015). Am. Mineral. 100, 787-794 [3]Lowenstern (2015). Am. Mineral. 100, 672-673 [4]Esposito, et al. (2016). Am. Mineral. 101, 1691-1708 [5]Kamenetsky et al. (2001). Earth Planet. Sci. Lett. 184, 685-702

Gemini Planet Imager Exoplanet Survey: Key Results Two Years Into The Survey

NASA Astrophysics Data System (ADS)

Marchis, Franck; Rameau, Julien; Nielsen, Eric L.; De Rosa, Robert J.; Esposito, Thomas; Draper, Zachary H.; Macintosh, Bruce; Graham, James R.; GPIES

2016-10-01

The Gemini Planet Imager Exoplanet Survey (GPIES) is targeting 600 young, nearby stars using the GPI instrument. We report here on recent results obtained with this instrument from our team.Rameau et al. (ApJL, 822 2, L2, 2016) presented astrometric monitoring of the young exoplanet HD 95086 b obtained with GPI between 2013 and 2016. Efficient Monte Carlo techniques place preliminary constraints on the orbital parameters of HD 95086 b. Under the assumption of a coplanar planet-disk system, the periastron of HD 95086 b is beyond 51 AU. Therefore, HD 95086 b cannot carve the entire gap inferred from the measured infrared excess in the SED of HD 95086. Additional photometric and spectroscopic measurements reported by de Rosa et al. (2016, apJ, in press) showed that the spectral energy distribution of HD 95086 b is best fit by low temperature (T~800-1300 K), low surface gravity spectra from models which simulate high photospheric dust content. Its temperature is typical to L/T transition objects, but the spectral type is poorly constrained. HD 95086 b is an important exoplanet to test our models of atmospheric properties of young extrasolar planets.Direct detections of debris disk are keys to infer the collisional past and understand the formation of planetary systems. Two debris disks were recently studied with GPI:- Draper et al. (submitted to ApJ, 2016) show the resolved circumstellar debris disk around HD 111520 at a projected range of ~30-100 AU using both total and polarized H-band intensity. Structures in the disks such as a large brightness asymmetry and symmetric polarization fraction are seen. Additional data would confirm if a large disruption event from a stellar fly-by or planetary perturbations altered the disk density- Esposito et al. (submitted to ApJ, 2016) combined Keck NIRC2 data taken at 1.2-2.3 microns and GPI 1.6 micron total intensity and polarized light detections that probes down to projected separations less than 10 AU to show that the HD

Health-Related Coping and Social Interaction in People with Multiple Sclerosis Supported by a Social Network: Pilot Study With a New Methodological Approach.

PubMed

Lavorgna, Luigi; Russo, Antonio; De Stefano, Manuela; Lanzillo, Roberta; Esposito, Sabrina; Moshtari, Fatemeh; Rullani, Francesco; Piscopo, Kyrie; Buonanno, Daniela; Brescia Morra, Vincenzo; Gallo, Antonio; Tedeschi, Gioacchino; Bonavita, Simona

2017-07-14

.com was perceived by users to be a useful tool to support health-related coping and social interaction, and may suggest a new kind of therapeutic alliance between physicians and people with MS. ©Luigi Lavorgna, Antonio Russo, Manuela De Stefano, Roberta Lanzillo, Sabrina Esposito, Fatemeh Moshtari, Francesco Rullani, Kyrie Piscopo, Daniela Buonanno, Vincenzo Brescia Morra, Antonio Gallo, Gioacchino Tedeschi, Simona Bonavita. Originally published in the Interactive Journal of Medical Research (http://www.i-jmr.org/), 14.07.2017.

Forming Inner Ice-Rich Moons at Saturn from a Massive Early Ring

NASA Astrophysics Data System (ADS)

Salmon, Julien; Canup, Robin M.

2014-11-01

Saturn’s rings are 90 to 95% water ice. As a group, Saturn’s moons interior to and including Tethys are also about 90% ice. The small inner moons (interior to and including Janus) are dynamically young with histories tied to that of the rings (e.g., Goldreich & Tremaine 1982; Esposito 1986). Charnoz et al. (2010) showed that ring material viscously spreading outward across the Roche limit can produce these small moons and their observed mass vs. distance relationship within the last 107 years. Canup (2010) proposed that at the end of Saturn’s formation, tidal stripping from a differentiated Titan-sized moon as it spiraled into Saturn could have produced a massive 1024 - 1025 g initial ice ring, and that Mimas, Enceladus and Tethys could have been similarly spawned from this primordial ring as it viscously evolved. Charnoz et al. (2011) considered a massive ice-rock ring and a tidal dissipation factor for Saturn of Q ˜ 103, and found that satellites out to Rhea could be spawned from such a ring. However the likelihood of such a small value for Q is debated. In addition, capture into mutual mean motion resonances and resulting eccentricity growth (not included in the Charnoz et al. model) could lead to orbital destabilization as the moons tidally expand over large distances (Peale & Canup 2014). Here we consider a dissipation factor for Saturn Q ˜ 104 - 105 and investigate whether Mimas, Enceladus and Tethys could have been spawned from a massive initial ice ring. In this scenario, the rock in these moons would be delivered by material from outside the rings, e.g. by heliocentric impactors during the LHB (Canup 2013). We have expanded a numerical model developed to study the accretion of Earth's Moon (Salmon and Canup 2012, 2014), which couples an analytic Roche-interior disk model to the N-body code SyMBA for material exterior to the Roche limit, so that we can directly track the accretion and mutual interactions of growing satellites (including mean

Surgical Interventions for the Treatment of Supracondylar Humerus Fractures in Children: Protocol of a Systematic Review.

PubMed

Carrazzone, Oreste Lemos; Belloti, João Carlos; Matsunaga, Fabio Teruo; Mansur, Nacime Salomão Barbachan; Matsumoto, Marcelo Hide; Faloppa, Flavio; Tamaoki, Marcel Jun Sugawara

2017-11-21

by a government-based noncommercial agency, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). This study may provide surgical treatment effects evidence for SHFC. The results will assist clinical practice by demonstrating the effectiveness and potential complications of these interventions and might serve as a reference for future clinical trials on the topic. PROSPERO CRD42014009304; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=9304 (Archived by WebCite at http://www.webcitation.org/6usiDHzD7). ©Oreste Lemos Carrazzone, João Carlos Belloti, Fabio Teruo Matsunaga, Nacime Salomão Barbachan Mansur, Marcelo Hide Matsumoto, Flavio Faloppa, Marcel Jun Sugawara Tamaoki. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 21.11.2017.

To Mercury dynamics

NASA Astrophysics Data System (ADS)

Barkin, Yu. V.; Ferrandiz, J. M.

Present significance of the study of rotation of Mercury considered as a core-mantle system arises from planned Mercury missions. New high accurate data on Mercury's structure and its physical fields are expected from BepiColombo mission (Anselmi et al., 2001). Investigation of resonant rotation of Mercury, begun by Colombo G. (1966), will play here main part. New approaches to the study of Mercury dynamics and the construction of analytical theory of its resonant rotation are suggested. Within these approaches Mercury is considered as a system of two non-spherical interacting bodies: a core and a mantle. The mantle of Mercury is considered as non-spherical, rigid (or elastic) layer. Inner shell is a liquid core, which occupies a large ellipsoidal cavity of Mercury. This Mercury system moves in the gravitational field of the Sun in resonant traslatory-rotary regime of the resonance 3:2. We take into account only the second harmonic of the force function of the Sun and Mercury. For the study of Mercury rotation we have been used specially designed canonical equations of motion in Andoyer and Poincare variables (Barkin, Ferrandiz, 2001), more convenient for the application of mentioned methods. Approximate observational and some theoretical evaluations of the two main coefficients of Mercury gravitational field J_2 and C22 are known. From observational data of Mariner-10 mission were obtained some first evaluations of these coefficients: J_2 =(8± 6)\\cdot 10-5(Esposito et al., 1977); J_2 =(6± 2)\\cdot 10-5and C22 =(1.0± 0.5)\\cdot 10-5(Anderson et al., 1987). Some theoretical evaluation of ratio of these coefficients has been obtained on the base of study of periodic motions of the system of two non-spherical gravitating bodies (Barkin, 1976). Corresponding values of coefficients consist: J_2 =8\\cdot 10-5and C22 =0.33\\cdot 10-5. We have no data about non-sphericity of inner core of Mercury. Planned missions to Mercury (BepiColombo and Messenger) promise to

Influence of shieldings or antioxidants on DNA damage and early and delyed cell death induced in human fibroblasts by accelerated 595 MeV/u Fe ions

NASA Astrophysics Data System (ADS)

Antonelli, Francesca; Esposito, Giuseppe; Dini, Valentina; Belli, Mauro; Campa, Alessandro; Sorrentino, Eugenio; Antonella Tabocchini, Maria; Lobascio, Cesare; Berra, Bruno

HZE particles from space radiation raise an important protection concern during long-term astronauts' travels. As high charge, high energy particles interact with a shield, both projec-tile and target fragmentation may occurs, so that the biological properties of the emerging radiation field depend on the nature and energy of the incident particles, and on the nature and thickness of the shield. We have studied the influence of PMMA and Kevlar shielding as well as the antioxidant compounds Rosmarinic acid or Resveratrol on DNA damage induction and processing (as evaluated by the g-H2AX phosphorylation assay) and on early and delayed cell death in AG01522 human fibroblasts irradiated with Fe ions of 595 MeV/u at the NASA Space Radiation Laboratory (NSRL), Brookhaven National Laboratory (BNL, Upton, USA). Insertion of PMMA or Kevlar shields (10 g/cm2 thick) gave no substantial change in the bio-logical effect per unit dose on the sample for all the end points studied. When irradiation was performed in the presence of 300 mM Rosmarinic acid or Resveratrol no difference were found for both early and delayed cell death, while a slight protective effect was observed for the initial and residual DNA damage. For both early and delayed cell death, Fe-ions are more effective than g-rays. The number of Fe-ion induced g-H2AX foci is instead lower than that induced by g-rays, due to the presence of multiple DSB within a single focus induced by Fe-ions. From a comparison of the g-H2AX data with the results on DNA fragmentation obtained with 414 MeV/u Fe ions at the Heavy Ions Medical Accelerator (HIMAC, Chiba, Japan) and with 1 GeV/u Fe ions at BNL, in the absence or in the presence of PMMA shields (Esposito et al, Advance in Space Research 2004) we speculate that the overall effect of the shield is a balance between the contributions due to the slowing down of the primary particles and that due to the nuclear fragmentation. Acknowledgment: Financial support from ASI project

The ESI scale, an ethical approach to the evaluation of seismic hazards

NASA Astrophysics Data System (ADS)

Porfido, Sabina; Nappi, Rosa; De Lucia, Maddalena; Gaudiosi, Germana; Alessio, Giuliana; Guerrieri, Luca

2015-04-01

studies have been reviewed: the destructive 1976 February 4 Guatemala, earthquake (M 7.5) and the 1743 February 20 Nardò, historical earthquake (Salento, Southern Italy). The re-analysis of both earthquakes contributes to define more realistic seismic scenarios in terms of intensities assessment and consequent regional seismic hazards. References Michetti A.M., Esposito E., Guerrieri L., Porfido S., Serva L., Tatevossian R., Vittori E., Audemard F., Azuma T., Clague J., Comerci V., Gurpinar A., Mccalpin J., Mohammadioun B., Mörner N.A, Ota Y. And E. Roghozin - 2007. Intensity Scale ESI 2007, Mem. Descrittive della Carta Geologica d'Italia, Roma, 74, 53 pp

Efficacy of laparoscopically assisted high ligation of patent processus vaginalis in children.

PubMed

Ahmed, H; Youssef, M K; Salem, E A; Fawzi, A M; Desoky, E A E; Eliwa, A M; Sakr, A M N; Shahin, A M S

2016-02-01

Laparoscopic hernia repairs have been proven to be efficient and safe for children, despite the slightly higher recurrence rate compared with the classic surgical repair. They have the advantage of easy and precise identification of the type of defect and its correction, both in ipsilateral and contralateral sides. The objectives of this study were to evaluate the efficacy, safety and outcome of the laparoscopically assisted piecemeal high ligation of a patent processus vaginalis (PPV) in children. A total of 40 children were enrolled into this prospective study; they were aged ≥ 6 months and had an inguinal hernia. The peritoneal cavity, including the contralateral side, was inspected for the possibility of bilateral hernias using a 3-mm 30° telescope. Another 3-mm port was introduced through the same infra-umbilical incision. The hernia was manually reduced or with the aid of a working infra-umbilical grasper. A prolene or vicryl 2/0 or 3/0 suture on a curved semicircle round-bodied taper-ended 25-30 mm needle was introduced through a very small inguinal skin-crease incision. It was passed through the abdominal wall layers to the peritoneum and was manipulated by the laparoscopic grasper to pick up the peritoneum in piecemeal all around the internal ring. The needle was then pushed to the outside near to the entrance site, thus forming a semicircle around the internal ring. The suture was then tied and the knot was subcutaneously buried. The primary outcome of the procedure was the incidence of intraoperative diagnosis and surgical repair of contralateral hernias in pre-operatively diagnosed unilateral cases. The secondary outcomes were defined as the incidence of complications and hernia recurrence. The exploratory laparoscopy found contralateral patent processus vaginalis (CPPV) with a detection rate of 28.1%. Chan et al., Esposito et al., Toufique et al. and Niyogi et al. reported similar figures for laparoscopic contralateral hernia detection rates of 28

Lake Biel Holocene sediment record before and after the Aare river deviation (1878 AD)

NASA Astrophysics Data System (ADS)

Jeannet, Alice; Corella, Juan Pablo; Kremer, Katrina; Girardclos, Stéphanie

2014-05-01

new river input is also linked to a massive and sudden Ti increase, and inversely abrupt Ca decrease in XRF data. This record reveals the significant alteration in the sediment dynamics, and the lake oxygenation changes that the lake experienced when it shifted from a relatively closed basin to a river and delta-influenced basin. Thank you to Flavio S. Anselmetti, Christine Guido and Frédéric Arlaud for help coring on the field and Stefanie Wirth for help at Limnogeology Laboratory. This study, undertaken as a Master thesis, was financed by the Swiss National Foundation projects 121666 and 146889. Reference Thevenon F. et al. 2013. Human impact on the transport of terrigenous and anthropogenic elements to peri-alpine lakes (Switzerland) over the last decades. Aquatic Sciences 75: 413-424.

Roman Travertine: proposed as a candidate for "Global Heritage Stone Resource" designation

NASA Astrophysics Data System (ADS)

Primavori, Piero

2017-04-01

Roman Travertine is one of the most long-standing and famous stones, used since the times of the Roman Empire. Together with Carrara and Botticino marbles, it is probably the most worldwide well-known and diffused Italian dimension stone. Travertine derives its name from the former town, known as Tibur in ancient Roman times; the ancient name for the stone was Lapis Tiburtinus, meaning Tibur Stone, which was gradually corrupted to Travertino (travertine). The Roman Travertine is geographically located circa 25 km to the east of Rome, Central Italy, in the hilly area of Guidonia-Montecelio and Tivoli. Its deposit, formed during late Pleistocene time over an active strike-slip fault nearby the Colli Albani quiescent volcano, is about 20 km2 wide and 60 m thick on average; the thickness is over 85 m toward its western N-S-elongated side, where thermal springs and large sinkholes occur in an aligned pattern. The first quarries date back to pre-Roman times; nowadays three main productive sub-zones can be recognized within the extractive basin: "Valle Pilella", "Barco" and "Le Fosse", where more than fifty quarries are in operation, together with a relevant number of processing plants and artisanal laboratories. Lithological and stratigraphical features allow the distinction of an extensive number of commercial varieties, being the most renowned the Classic, the Bianco, the Noce, the Paglierino, the Navona. Used since more than 2.500 years, the Roman Travertine has deeply characterized the architecture of Rome and its history, with the realization of villas, palaces, artistic and monumental buildings, and masterpieces with unmistakable features, such as the Anfiteatro Flavio (the Colosseum), the Theatre of Marcellus, the St. Peter's Basilica and Colonnade, the Tritone Fountain, the Adriana Villa, the Trevi Fountain, and many others. From Renaissance times on, the travertine has been extensively used to build an innumerable amount of churches, common buildings and houses

Prefazione al volume 9 di Gerbertus in Transitu Mercurii

NASA Astrophysics Data System (ADS)

Sigismondi, Costantino

2016-05-01

observed in phase with new Moon. 11. The penumbral phase of the lunar eclipse of 28/9/2015 and 12. 2015 four PHEMU are observed visually and digitally. The transit of Mercury on the Sun could have been predicted or/and observed at the time of Gerbert? The 13th roman congress on Gerbert is celebrated the day of 2016 transit: their 13. algebra, 14. physics (solar) and 15. optical astronomy are discussed in detail. 16. The measurement of the solar diameter with the eclipse of 9 march 2016 is obtained, using public domain data. 17. The Carme figuratum of Gerbert was dedicated to the Emperor Otto II: Flavio Nuvolone enlighten this aspect of early middle age literature of court poets, with chryptographical schemes.

Applying the seismic interferometry method to vertical seismic profile data using tunnel excavation noise as source

NASA Astrophysics Data System (ADS)

Jurado, Maria Jose; Teixido, Teresa; Martin, Elena; Segarra, Miguel; Segura, Carlos

2013-04-01

response and the reflection response for a 1D multilayer structure, and next 3D approach (Wapenaar 2004). As a result of this seismic interferometry experiment the 3D reflectivity model (frequencies and resolution ranges) was obtained. We proved also that the seismic interferometry approach can be applied in asynchronous seismic auscultation. The reflections detected in the virtual seismic sections are in agreement with the geological features encountered during the excavation of the tunnel and also with the petrophysical properties and parameters measured in previous geophysical borehole logging. References Claerbout J.F., 1968. Synthesis of a layered medium from its acoustic transmision response. Geophysics, 33, 264-269 Flavio Poletto, Piero Corubolo and Paolo Comeli.2010. Drill-bit seismic interferometry whith and whitout pilot signals. Geophysical Prospecting, 2010, 58, 257-265. Wapenaar, K., J. Thorbecke, and D. Draganov, 2004, Relations between reflection and transmission responses of three-dimensional inhomogeneous media: Geophysical Journal International, 156, 179-194.

The distribution of atomic hydrogen and oxygen in the magnetosphere of Saturn

NASA Astrophysics Data System (ADS)

Melin, Henrik; Shemansky, Don E.; Liu, Xianming

2009-12-01

The intensity of H Ly α1216A˚ ( 2P- 1S) and OI 1304A˚ ( 2p33s3S-2p4P) is mapped in the magnetosphere of Saturn using the ultraviolet imaging spectrograph (UVIS) [Esposito, L.W., Barth, C.A., Colwell, J.E., Lawrence, G.M., McClintock, W.E., Stewart, A.I.F., Keller, H.U., Korth, A., Lauche, H., Festou, M.C., Lane, A.L., Hansen, C.J., Maki, J.N., West, R.A., Jahn, H., Reulke, R., Warlich, K., Shemansky, D.E., Yung, Y.L., 2004. The Cassini ultraviolet imaging spectrograph investigation. Space Science Reviews 115, 299-361] onboard Cassini. Spatial coverage is built up by stepping the slit sequentially across the system (system scan). Data are obtained at a large range of space-craft-Saturn distances. The observed atomic hydrogen distribution is very broad, extending beyond 40RS in the equatorial plane, with the intensity increasing with decreasing distances to Saturn. The distribution displays persistent local-time asymmetries, and is seen connecting continuously to the upper atmosphere of the planet at sub-solar latitudes located well outside of the equatorial (ring) plane. This is consistent with the source of the atomic hydrogen being located at the top of the atmosphere on the sun-lit side of the planet on the southern hemisphere. In addition there are a number of temporally persistent features in the intensity distribution, indicating a complex hydrogen energy distribution. The emission from OI 1304A˚ is generally distributed as a broad torus centered around ˜4RS although the position of the peak intensity can vary by as much as ±1RS. There is significant intensity present out to ±10RS. HST observations of hydroxyl (OH) are re-analyzed and display a distribution half as broad as that of oxygen, also centered at 4RS. The observed atomic oxygen distribution requires a sourcing of 1.3×1028atomss-1 against loss due to charge capture with the plasma. Using the ion partitioning of Schippers et al. [2008. Multi-instrument analysis of electron populations in Saturn

Proceedings of RIKEN BNL Research Center Workshop: Progress in High-pT Physics at RHIC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bazilevsky, A.; Bland, L.; Vogelsang, W.

2010-03-17

had excellent presentations throughout and productive discussions, which showed the importance and unique value of the RHIC high-p{sub T} program. We are grateful to all participants for coming to BNL. The support provided by the RIKEN-BNL Research Center for this workshop has been magnificent, and we are most grateful for it. We also thank Brookhaven National Laboratory and the U.S. Department of Energy for providing additional support and for the facilities to hold this workshop. Finally, sincere thanks go to Pamela Esposito for her most efficient and tireless work in organizing and running the workshop.« less

Internet Use and Access, Behavior, Cyberbullying, and Grooming: Results of an Investigative Whole City Survey of Adolescents.

PubMed

Vismara, Marco Flavio Michele; Toaff, Joseph; Pulvirenti, Giuliana; Settanni, Chiara; Colao, Emma; Lavano, Serena Marianna; Cemicetti, Riccardo; Cotugno, David; Perrotti, Giuseppe; Meschesi, Viviana; Montera, Roberto; Zepponi, Barbara; Rapetto, Umberto; Marotta, Rosa

2017-08-29

interviewed teenagers have uploaded pictures or movies of which they felt ashamed; 27.05% (415/1534) have received invitations from people they met on the Internet to meet in real life; and 8.67% (133/1534) have accepted such invitations. The results offer a breakdown of the teenagers' use of the Internet, focusing on how teenagers learn to use and access it while taking into account factors such as parental coaching, schooling, or self-education. It describes how they approach and interact with social networks and how they perceive risks and risky behaviors on the Internet. Information technology must be seen as an instrument and not as a hindrance. For this to happen, parental guidance, schooling, and medical counseling are needed for a sound development of the child in this critical stage. ©Marco Flavio Michele Vismara, Joseph Toaff, Giuliana Pulvirenti, Chiara Settanni, Emma Colao, Serena Marianna Lavano, Riccardo Cemicetti, David Cotugno, Giuseppe Perrotti, Viviana Meschesi, Roberto Montera, Barbara Zepponi, Umberto Rapetto, Rosa Marotta. Originally published in the Interactive Journal of Medical Research (http://www.i-jmr.org/), 29.08.2017.

Structural events in the photocycle of green fluorescent protein.

PubMed

van Thor, Jasper J; Zanetti, Giulia; Ronayne, Kate L; Towrie, Michael

2005-08-25

Picosecond time-resolved mid-infrared absorption changes of the wild type green fluorescent protein from Aequorea victoria are reported on structural events during the photocycle. Concomitant with rapid H/D transfer following excitation of the neutral A state at 400 nm, a transient signal at 1721/1711 cm(-1) (H/D) developed belonging to protonated glutamate 222, which was definitively assigned using the E222D mutant from the altered proton-transfer kinetics to aspartate in addition to the altered band position and intensity in the spectra. A transient at 1697 cm(-1), assigned to a structural perturbation of glutamine 69, had a H/D kinetic isotope effect of >32, showing the conformational dynamics to be sensitive to the active site H/D vibrations. The kinetic data up to 2 ns after excitation in the 1250-1800 cm(-1) region in D2O provided 10 and 75 ps time constants for the excited-state deuteron transfer and the associated A1* - A1 and A2* - A2 difference spectra and showed the radiative intermediate I state vibrations and the transient accumulation of the long-lived ground-state intermediate I2. Assignments of chromophore modes for the A1, A2, and I2 ground states are proposed on the basis of published model compound studies (Esposito, A. P.; Schellenberg, P.; Parson, W. W.; Reid, P. J. J. Mol. Struct. 2001, 569, 25 and He, X.; Bell, A. F.; Tonge, P. J. J. Phys. Chem. B 2002, 106, 6056). Tentative assignments for the singlet-state intermediates A1*, A2*, and I* are discussed. An unexpected and unassigned band that may be a C=C chromophore vibration was observed in the ground state (1665 cm(-1)) as well as in all photocycle intermediates. Optical dumping of the transient I population was achieved using an additional 532 nm pulse and the directly obtained I2 - I* difference spectrum was highly similar to the I2 - I* photocycle spectrum. The pump-dump-probe spectrum differed from the pump-probe photocycle difference spectrum with respect to the intensity of the phenol

Testing and ground calibration of DREAMS-H relative humidity device

NASA Astrophysics Data System (ADS)

Genzer, Maria; Hieta, Maria; Nikkanen, Timo; Schmidt, Walter; Kemppinen, Osku; Harri, Ari-Matti; Haukka, Harri

2015-04-01

were measured at several temperature points between 0°C and -70°C. Dry baseline was established in vacuum measurements at the Finnish Meteorological Institute. In addition to stable relative humidity points, measurements in changing relative humidity and temperature were done in order to get information about the lag of the sensor. References: 1] Esposito, F. et al: The DREAMS Experiment on the ExoMars 2016 Mission for the Study of Martian Environment during the Dust Storm Season, The Fifth International Workshop on the Mars Atmosphere, 13-16 January 2014, Oxford, UK, 2014. [2] Gómez-Elvira, J. et al.: REMS: The Environmental Sensor Suite for the Mars Science Laboratory Rover, Space Sci. Rev., 170, pp. 583-640, 2012. [3] Harri, A.-M. et al.: Mars Science Laboratory Relative Humidity Observations - Initial Results, JGR Planets, Vol 119 Issue 9, pp. 2132-2147, 2014.

Effets Josephson generalises entre antiferroaimants et entre supraconducteurs antiferromagnetiques

NASA Astrophysics Data System (ADS)

Chasse, Dominique

L'effet Josephson est generalement presente comme le resultat de l'effet tunnel coherent de paires de Cooper a travers une jonction tunnel entre deux supraconducteurs, mais il est possible de l'expliquer dans un contexte plus general. Par exemple, Esposito & al. ont recemment demontre que l'effet Josephson DC peut etre decrit a l'aide du boson pseudo-Goldstone de deux systemes couples brisant chacun la symetrie abelienne U(1). Puisque cette description se generalise de facon naturelle a des brisures de symetries continues non-abeliennes, l'equivalent de l'effet Josephson devrait donc exister pour des types d'ordre a longue portee differents de la supraconductivite. Le cas de deux ferroaimants itinerants (brisure de symetrie 0(3)) couples a travers une jonction tunnel a deja ete traite dans la litterature Afin de mettre en evidence la generalite du phenomene et dans le but de faire des predictions a partir d'un modele realiste, nous etudions le cas d'une jonction tunnel entre deux antiferroaimants itinerants. En adoptant une approche Similaire a celle d'Ambegaokar & Baratoff pour une jonction Josephson, nous trouvons un courant d'aimantation alternee a travers la jonction qui est proportionnel a sG x sD ou fG et sD sont les vecteurs de Neel de part et d'autre de la jonction. La fonction sinus caracteristique du courant Josephson standard est donc remplacee.ici par un produit vectoriel. Nous montrons que, d'un point de vue microscopique, ce phenomene resulte de l'effet tunnel coherent de paires particule-trou de spin 1 et de vecteur d'onde net egal au vecteur d'onde antiferromagnetique Q. Nous trouvons egalement la dependance en temperature de l'analogue du courant critique. En presence d'un champ magnetique externe, nous obtenons l'analogue de l'effet Josephson AC et la description complete que nous en donnons s'applique aussi au cas d'une jonction tunnel entre ferroaimants (dans ce dernier cas, les traitements anterieurs de cet effet AC s'averent incomplets). Nous

Cassini UVIS Observations of Titan Ultraviolet Airglow Spectra with Laboratory Modeling from Electron- and Proton-Excited N2 Emission Studies

NASA Astrophysics Data System (ADS)

Ajello, J. M.; West, R. A.; Malone, C. P.; Gustin, J.; Esposito, L. W.; McClintock, W. E.; Holsclaw, G. M.; Stevens, M. H.

2011-12-01

Joseph M. Ajello, Robert A. West, Rao S. Mangina Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 Charles P. Malone Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 & Department of Physics, California State University, Fullerton, CA 92834 Michael H. Stevens Space Science Division, Naval Research Laboratory, Washington, DC 20375 Jacques Gustin Laboratoire de Physique Atmosphérique et Planétaire, Université de Liège, Liège, Belgium A. Ian F. Stewart, Larry W. Esposito, William E. McClintock, Gregory M. Holsclaw Laboratory for Atmospheric and Space Physics, University of Colorado, Boulder, CO 80303 E. Todd Bradley Department of Physics, University of Central Florida, Orlando, FL 32816 The Cassini Ultraviolet Imaging Spectrograph (UVIS) observed photon emissions of Titan's day and night limb-airglow and disk-airglow on multiple occasions, including three eclipse observations from 2009 through 2010. The 77 airglow observations analyzed in this paper show EUV (600-1150 Å) and FUV (1150-1900 Å) atomic multiplet lines and band emissions (lifetimes less than ~100 μs), including the Lyman-Birge-Hopfield (LBH) band system, arising from photoelectron induced fluorescence and solar photo-fragmentation of molecular nitrogen (N2). The altitude of peak UV emission on the limb of Titan during daylight occurred inside the thermosphere/ionosphere (near 1000 km altitude). However, at night on the limb, the same emission features, but much weaker in intensity, arise in the lower atmosphere below 1000 km (lower thermosphere, mesosphere, haze layer) extending downwards to near the surface at ~300 km, possibly resulting from proton- and/or heavier ion-induced emissions as well as secondary-electron-induced emissions. The eclipse observations are unique. UV emissions were observed during only one of the three eclipse events, and no Vegard-Kaplan (VK) or LBH emissions were seen. Through regression analysis using

EDITORIAL: Quantum phenomena in Nanotechnology Quantum phenomena in Nanotechnology

NASA Astrophysics Data System (ADS)

Loss, Daniel

2009-10-01

of quantum cellular automata, a new paradigm for computing as reported by Craig S Lent and colleagues (Lent C S, Tougaw P D, Porod W and Bernstein G H 1993 Nanotechnology 4 49-57). The increasingly sophisticated manipulation of spin has been an enduring theme of research throughout this decade, providing a number of interesting developments such as spin pumping (Cota E, Aguado R, Creffield C E and Platero G 2003 Nanotechnology 14 152-6). The idea of spin qubits, proposed by D Loss and D P DiVincenzo (1998 Phys. Rev. A 57 120), developed into an established option for advancing research in quantum computing and continues to drive fruitful avenues of research, such as the integrated superconductive magnetic nanosensor recently devised by researchers in Italy (Granata C, Esposito E, Vettoliere A, Petti L and Russo M 2008 Nanotechnology 19 275501). The device has a spin sensitivity in units of the Bohr magneton of 100 spin Hz-1/2 and has large potential for applications in the measurement of nanoscale magnetization and quantum computing. The advance of science and technology at the nanoscale is inextricably enmeshed with advances in our understanding of quantum effects. As Nanotechnology celebrates its 20th volume, research into fundamental quantum phenomena continues to be an active field of research, providing fertile pasture for developing nanotechnologies.

Gap Assessment (FY 13 Update)

DOE Data Explorer

Getman, Dan

2013-09-30

To help guide its future data collection efforts, The DOE GTO funded a data gap analysis in FY2012 to identify high potential hydrothermal areas where critical data are needed. This analysis was updated in FY2013 and the resulting datasets are represented by this metadata. The original process was published in FY 2012 and is available here: https://pangea.stanford.edu/ERE/db/GeoConf/papers/SGW/2013/Esposito.pdf Though there are many types of data that can be used for hydrothermal exploration, five types of exploration data were targeted for this analysis. These data types were selected for their regional reconnaissance potential, and include many of the primary exploration techniques currently used by the geothermal industry. The data types include: 1. well data 2. geologic maps 3. fault maps 4. geochemistry data 5. geophysical data To determine data coverage, metadata for exploration data (including data type, data status, and coverage information) were collected and catalogued from nodes on the National Geothermal Data System (NGDS). It is the intention of this analysis that the data be updated from this source in a semi-automated fashion as new datasets are added to the NGDS nodes. In addition to this upload, an online tool was developed to allow all geothermal data providers to access this assessment and to directly add metadata themselves and view the results of the analysis via maps of data coverage in Geothermal Prospector (http://maps.nrel.gov/gt_prospector). A grid of the contiguous U.S. was created with 88,000 10-km by 10-km grid cells, and each cell was populated with the status of data availability corresponding to the five data types. Using these five data coverage maps and the USGS Resource Potential Map, sites were identified for future data collection efforts. These sites signify both that the USGS has indicated high favorability of occurrence of geothermal resources and that data gaps exist. The uploaded data are contained in two data files for

Impact of a Web-Based Electronic Health Record on Behavioral Health Service Delivery for Children and Adolescents: Randomized Controlled Trial.

PubMed

Bruns, Eric J; Hook, Alyssa N; Parker, Elizabeth M; Esposito, Isabella; Sather, April; Parigoris, Ryan M; Lyon, Aaron R; Hyde, Kelly L

2018-06-14

Wraparound model, and satisfaction with services. EHR-assigned facilitators from both sites demonstrated the robust use of the system. Facilitators in the EHR group reported spending significantly more time reviewing client progress (P=.03) in supervision, and less time overall sending reminders to youth/families (P=.04). A trend toward less time on administrative tasks (P=.098) in supervision was also found. Facilitators in both groups reported significantly increased use of measurement-based care strategies overall, which may reflect cross-group contamination (given that randomization of staff to the EHR occurred within agencies and supervisors supervised both types of staff). Although not significant at P<.05, there was a trend (P=.10) toward caregivers in the EHR group reporting poorer shared agreement on tasks on the measure of working alliance with providers. No other significant between-group differences were found. Results support the proposal that use of EHR systems can promote the use of client progress data and promote efficiency; however, there was little evidence of any impact (positive or negative) on overall service quality, fidelity, or client satisfaction. The field of children's behavioral health services would benefit from additional research on EHR systems using designs that include larger sample sizes and longer follow-up periods. ClinicalTrials.gov NCT02421874; https://clinicaltrials.gov/ct2/show/NCT02421874 (Archived by WebCite at http://www.webcitation.org/6yyGPJ3NA). ©Eric J Bruns, Alyssa N Hook, Elizabeth M Parker, Isabella Esposito, April Sather, Ryan M Parigoris, Aaron R Lyon, Kelly L Hyde. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 14.06.2018.

Moonlet induced wakes in planetary rings: Analytical model including eccentric orbits of moon and ring particles

NASA Astrophysics Data System (ADS)

Seiß, M.; Spahn, F.; Schmidt, Jürgen

2010-11-01

Saturn's rings host two known moons, Pan and Daphnis, which are massive enough to clear circumferential gaps in the ring around their orbits. Both moons create wake patterns at the gap edges by gravitational deflection of the ring material (Cuzzi, J.N., Scargle, J.D. [1985]. Astrophys. J. 292, 276-290; Showalter, M.R., Cuzzi, J.N., Marouf, E.A., Esposito, L.W. [1986]. Icarus 66, 297-323). New Cassini observations revealed that these wavy edges deviate from the sinusoidal waveform, which one would expect from a theory that assumes a circular orbit of the perturbing moon and neglects particle interactions. Resonant perturbations of the edges by moons outside the ring system, as well as an eccentric orbit of the embedded moon, may partly explain this behavior (Porco, C.C., and 34 colleagues [2005]. Science 307, 1226-1236; Tiscareno, M.S., Burns, J.A., Hedman, M.M., Spitale, J.N., Porco, C.C., Murray, C.D., and the Cassini Imaging team [2005]. Bull. Am. Astron. Soc. 37, 767; Weiss, J.W., Porco, C.C., Tiscareno, M.S., Burns, J.A., Dones, L. [2005]. Bull. Am. Astron. Soc. 37, 767; Weiss, J.W., Porco, C.C., Tiscareno, M.S. [2009]. Astron. J. 138, 272-286). Here we present an extended non-collisional streamline model which accounts for both effects. We describe the resulting variations of the density structure and the modification of the nonlinearity parameter q. Furthermore, an estimate is given for the applicability of the model. We use the streamwire model introduced by Stewart (Stewart, G.R. [1991]. Icarus 94, 436-450) to plot the perturbed ring density at the gap edges. We apply our model to the Keeler gap edges undulated by Daphnis and to a faint ringlet in the Encke gap close to the orbit of Pan. The modulations of the latter ringlet, induced by the perturbations of Pan (Burns, J.A., Hedman, M.M., Tiscareno, M.S., Nicholson, P.D., Streetman, B.J., Colwell, J.E., Showalter, M.R., Murray, C.D., Cuzzi, J.N., Porco, C.C., and the Cassini ISS team [2005]. Bull. Am

DREAMS: a payload on-board the ExoMars EDM Schiaparelli for the characterization of Martian environment during the statistical dust storm season

NASA Astrophysics Data System (ADS)

Molfese, Cesare; Esposito, Francesca; Debei, Stefano; Bettanini, Carlo; Arruego Rodríguez, Ignacio; Colombatti, Giacomo; Harri, Ari-Matty.; Montmessin, Franck; Wilson, Colin; Aboudan, Alessio; Mugnuolo, Raffaele; Pirrotta, Simone; Marchetti, Ernesto; Witasse, Olivier

2015-04-01

F. Esposito1, S. Debei2, C. Bettanini2, C. Molfese1, I. Arruego Rodríguez3, G. Colombatti2, A-M. Harri4, F. Montmessin5, C. Wilson6, A. Aboudan2, S. Abbaki5, V. Apestigue3, G. Bellucci7, J-J. Berthelier5, J. R. Brucato8, S. B. Calcutt6, F. Cortecchia1, F. Cucciarrè2, G. Di Achille1, F. Ferri2, F. Forget9, E. Friso2, M. Genzer4, P. Gilbert5, H. Haukka4, J. J. Jiménez3, S. Jiménez10, J-L. Josset11, O. Karatekin12, G. Landis13, R. Lorenz14, J. Martinez3, L. Marty1, V. Mennella1, D. Möhlmann15, D. Moirin5, R. Molinaro1, E. Palomba7, M. Patel16, J-P. Pommereau5, C.I. Popa1, S. Rafkin17, P. Rannou18, N.O. Renno19, P. Schipani1, W. Schmidt4, E. Segato2, S. Silvestro1, F. Simoes20, A. Spiga9, F. Valero21, L. Vázquez21, F. Vivat5, O. Witasse22, R. Mugnuolo23, S. Pirrotta23, E.Marchetti23 1INAF - Osservatorio Astronomico di Capodimonte, Napoli, Italy, 2CISAS - Università degli Studi di Padova, Padova, Italy, 3INTA, Spain, 4Finnish Meteorological Institute (FMI),Helsinki, Finland, 5LATMOS - CNRS/UVSQ/IPSL, France, 6Oxford University, Oxford, United Kingdom, 7INAF - Istituto di Fisica dello Spazio Interplanetario (IFSI), 8INAF-Osservatorio Astrofisico di Arcetri, 9CNRS, LMD, France, 10Universidad Politécnica de Madrid, Spain, 11Space Exploration Institute, Switzerland, 12Royal Observatory of Belgium,Belgium, 13NASA, GRC, USA, 14JHU Applied Physics Lab (JHU-APL), USA, 15DLR PF Leitungsbereich, Berlin, Germany, 16Open University, UK, 17SwRL, Switzerland, 18GSMA, France, 19University of Michigan, USA, 20NASA, GSFC, USA, 21Universidad Complutense de Madrid (UCM), Spain, 22ESA-ESTEC, Noordwijk, The Netherlands, 23Italian Space Agency, Italy DREAMS (Dust characterization, Risk assessment and Environment Analyzer on the Martian Surface) package is an integrated multi-sensor scientific payload dedicated to characterizing the landing site environment in dusty conditions. It will measure pressure, wind speed and direction, relative humidity, temperature, the solar irradiance

PREFACE: Water Interfaces in Physics Chemistry and Biology: a multi-disciplinary approach

NASA Astrophysics Data System (ADS)

Bellissent-Funel, Marie-Claire; Dore, John

2009-07-01

meeting as well as five extended abstracts. 1. Initial Filling Mechanism of Predominant Water Adsorption on Hydrophobic Slit-Shaped Carbon Nanopores Tomonori Ohba and Katsumi Kaneko 2. Computer simulation study of water/hydrocarbon interfaces: effects of hydrocarbon branching on interfacial properties Janamejaya Chowdhary and Branka M Ladanyi 3. Thermodynamics of supercooled water in solutions D Corradini, P Gallo and M Rovere 4. Transferability of polarizable models for ion-water electrostatic interaction Marco Masia 5. Quantum chemical study of water impact on the calcium hydroxyapatite V D Khavryuchenko, O V Khavryuchenko, V V Lisnyak 6. Neutron Scattering Studies of Dynamic Crossover Phenomena in a Coupled System of Biopolymer and Its Hydration Water Sow-Hsin Chen, F Mallamace, X Q Chu, C Kim, M Lagi, A Faraone, E Fratini, P Baglioni 7. Looking for the best experimental conditions to detail the protein solvation shell in a binary aqueous solvent via Small Angle Scattering Maria Grazia Ortore, Raffaele Sinibaldi, Francesco Spinozzi, Andrea Carbini, Flavio Carsughi and Paolo Mariani 8. Influence of the water molecules near surface of viral protein on virus activation process S O Shepelenko, A S Salnikov, S V Rak, E P Goncharova and A B Ryzhikov 9. Optical Kerr effect measurements on supercooled water: the experimental perspectives P. Bartolini, A Taschin, R Eramo, R Righini and R Torre 10. Structural studies of water confined in a confined hydrophobic environment J C Dore, M-C Bellissent-Funel, A Burian, H P Castricum, J Jelassi, K Kaneko, T Ohba, H Tanaka and J B W Webber 11. Dynamic transition and glassy behaviour in hydrated proteins F Mezei, M Russina, G Chen, H Frauenfelder, P W Fenimore, P Falus and B Farago 12. Relation between frequency and H bond length in heavy water: Towards the understanding of the unusual properties of H bond dynamics in nanoporous media S Pommeret, R Musat, J-P Renault, J-C Leicknam and S Bratos 13. Quantum confinement of hydrogen in ice

PREFACE: 17th International Conference on the Physics of Highly Charged Ions

NASA Astrophysics Data System (ADS)

2015-01-01

sources and Roberto Garibotti, for his help with the edition of the book of abstracts. We thank Lynn van Brook for her work as conference secretary, and Silvana Peralta and Natalia Mastrángelo, for the web development and graphic design. Finally, we express our acknowledgements to the scientists that participated during the refereeing process of the present Proceedings. Raúl Barrachina Flavio Colavecchia Roberto Rivarola Local Chairs, HCI 2014 December 2014

Scattering properties of Saturn's rings in the far ultraviolet from Cassini UVIS spectra

NASA Astrophysics Data System (ADS)

Bradley, E. Todd; Colwell, Joshua E.; Esposito, Larry W.

2013-07-01

We use Cassini UVIS data to determine the scattering properties of Saturn's ring particles in the FUV. We have replaced the scattering function from the classical Chandrasekhar single scattering radiative transfer equation for reflectance with a ring wake model for the A and B rings derived from stellar occultations. The free parameters in this model are the ring particle Bond albedo, AB, and the ring particle asymmetry parameter, g, which equals the cosine of the most probable scattering angle of a photon from a ring particle. The spectrum of Saturn's rings from 140 to 190 nm shows an absorption feature due to water ice shortward of 165 nm. We compare our model values for I/F to lit-side data at 155 nm and at 180 nm for regions in both the A and B rings. We used the unmodified Chandrasekhar model for the C ring and Cassini Division, and in all cases we determined AB and g in the FUV for the first time. Values of AB vary between 0.04 and 0.091 at 180 nm and between 0.012 and 0.019 at 155 nm. The variations across the ring of AB at 180 nm is consistent with a greater abundance of non-ice contaminant in the C ring and Cassini Division and a minimum in contaminant abundance in the outer B ring. There is little variation in AB at 155 nm across the rings, which suggests that the reflectance of the water ice and non-water ice material shortward of the 165 nm absorption edge are about the same. Values of g vary between -0.68 and -0.78 at 180 nm and between -0.63 and -0.77 at 155 nm showing that the ring particles are highly backscattering in the FUV. We find that the wavelength of the absorption feature varies with ring region and viewing geometry indicating a different photon mean path length, L, through the outer layer of the ring particle (Bradley, E.T., Colwell, J.E., Esposito, L.W., Cuzzi, J.N., Tollerud, H., Chambers, L. [2010]. Icarus 206 (2), 458-466). We compared I/F from 152 to 185 nm to a radiative transfer spectral model developed by Shkuratov et al

PREFACE: Strongly Coupled Coulomb Systems Strongly Coupled Coulomb Systems

NASA Astrophysics Data System (ADS)

Neilson, David; Senatore, Gaetano

2009-05-01

, condensed matter and ultra-cold plasmas. One hundred and thirty participants came from twenty countries and four continents to participate in the conference. Those giving presentations were asked to contribute to this special issue to make a representative record of an interesting conference. We thank the International Advisory Board and the Programme Committee for their support and suggestions. We thank the Local Organizing Committee (Stefania De Palo, Vittorio Pellegrini, Andrea Perali and Pierbiagio Pieri) for all their efforts. We highlight for special mention the dedication displayed by Andrea Perali, by Rocco di Marco for computer support, and by our tireless conference secretary Fiorella Paino. The knowledgeable guided tour of the historic centre of Camerino given by Fiorella Paino was appreciated by many participants. It is no exaggeration to say that without the extraordinary efforts put in by these three, the conference could not have been the success that it was. For their sustained interest and support we thank Fulvio Esposito, Rector of the University of Camerino, Fabio Beltram, Director of NEST, Scuola Normale Superiore, Pisa, and Daniel Cox, Co-Director of ICAM, University of California at Davis. We thank the Institute of Complex and Adaptive Matter ICAM-I2CAM, USA for providing a video record of the conference on the web (found at http://sccs2008.df.unicam.it/). Finally we thank the conference sponsors for their very generous support: the University of Camerino, the Institute of Complex and Adaptive Matter ICAM-I2CAM, USA, the International Centre for Theoretical Physics ICTP Trieste, and CNR-INFM DEMOCRITOS Modeling Center for Research in Atomistic Simulation, Trieste. Participants at the International Conference on Strongly Coupled Coulomb Systems (SCCS) (University of Camerino, Italy, 29 July-2 August 2008).

High resolution seismic reflection survey in the Gulf of Pozzuoli, Naples, Italy. An example of preliminary interpretation of seismic profiles.

NASA Astrophysics Data System (ADS)

D'Aniello, Elena; di Fiore, Vincenzo; Sacchi, Marco; Rapolla, Antonio

2010-05-01

were recognized. The correspondence between magnetic structures, interpreted as volcanic bodies, and the faults NE-SW and NW-SE trending, supports the hypothesis that the magma rises along normal faults cutting the carbonate platform. We here present two significant seismic profiles: their interpretation reveals a complex stratigraphic and structural setting, dominated by the occurrence of volcanic bodies and siliciclastic depositional units, mostly deriving from the dismantling of the adjacent vents and volcaniclastic units. The results of this preliminary research include the recognition of volcanic features and structures not yet described in the literature that may represent a relevant contribute to the understanding of the Late Quaternary evolution of the Campi Flegrei area. References: Bruno P.P., Rapolla A., Di Fiore V., 2003. Structural setting of the Bay of Naples (Italy) seismic reflection data: implications for Campanian volcanism. Tectonophysics, 372, 193-213. Bruno P.P., 2004. Structure and evolution of the Bay of Pozzuoli (Italy) using marine seismic reflection data: implication for collapse of the Campi Flegrei caldera. Bull. Volcanol., 66, 342-355. Di Fiore V., D'Aniello E., Rapolla A., Sacchi M., Secomandi M., Spiess V., 2009. Multichannel seismic survey in coastal Campania area by two different resolution sources. EGU General Assembly 2009, vol.11. Sacchi M., Alessio G., Aquino I., Esposito E., Molisso F., Nappi R., Porfido S., Violante C., 2008. Risultati preliminari della campagna oceanografica CAFE_07 - Leg 3 nei Golfi di Napoli e Pozzuoli, Mar Tirreno Orientale. Quaderni di Geofisica, n. 64. Secomandi M., Paoletti V., Aiello G., Fedi M., Marsella E., Ruggieri S., D'Argenio B., Rapolla A., 2003. Analysis of the magnetic anomaly field of the volcanic district of the Bay of Naples, Italy. Marine Geophysical Researches. 24: 207-221.

Soft tissue management for dental implants: what are the most effective techniques? A Cochrane systematic review.

PubMed

Esposito, Marco; Maghaireh, Hassan; Grusovin, Maria Gabriella; Ziounas, Ioannis; Worthington, Helen V

2012-01-01

This review is based on a Cochrane systematic review entitled 'Interventions for replacing missing teeth: management of soft tissues for dental implants' published in The Cochrane Library (see http:// www.cochrane.org/ for information). Cochrane systematic reviews are regularly updated to include new research, and in response to comments and criticisms from readers. If you wish to comment on this review, please send your comments to the Cochrane website or to Marco Esposito. The Cochrane Library should be consulted for the most recent version of the review. The results of a Cochrane review can be interpreted differently, depending on people's perspectives and circumstances. Please consider the conclusions presented carefully. They are the opinions of the review authors, and are not necessarily shared by the Cochrane Collaboration. To evaluate whether flapless procedures are beneficial for patients and which is the ideal flap design, whether soft tissue correction/augmentation techniques are beneficial for patients and which are the best techniques, whether techniques to increase the peri-implant keratinised mucosa are beneficial for patients and which are the best techniques, and which are the best suturing techniques/ materials. The Cochrane Oral Health Group's Trials Register, CENTRAL, MEDLINE and EMBASE were searched up to the 9th of June 2011 for randomised controlled trials (RCTs) of rootform osseointegrated dental implants, with a follow-up of at least 6 months after function, comparing various techniques to handle soft tissues in relation to dental implants. Primary outcome measures were prosthetic failures, implant failures and biological complications. Screening of eligible studies, assessment of the methodological quality of the trials and data extraction were conducted at least in duplicate and independently by two or more review authors. The statistical unit was the patient and not the prosthesis, the procedure or the implant. RESULTS were expressed

Jupiter

NASA Astrophysics Data System (ADS)

Bagenal, Fran; Dowling, Timothy E.; McKinnon, William B.

2007-03-01

Preface; 1. Introduction F. Bagenal, T. E. Dowling and W. B. McKinnon; 2. The origin of Jupiter J. I. Lunine, A. Corandini, D. Gautier, T. C. Owen and G. Wuchterl; 3. The interior of Jupiter T. Guillot, D. J. Stevenson, W. B. Hubbard and D. Saumon; 4. The composition of the atmosphere of Jupiter F. W. Taylor, S. K. Atreya, Th. Encrenaz, D. M. Hunten, P. G. J. Irwin and T. C. Owen; 5. Jovian clouds and haze R. A. West, K. H. Baines, A. J. Friedson, D. Banfield, B. Ragent and F. W. Taylor; 6. Dynamics of Jupiter's atmosphere A. P. Ingersoll, T. E. Dowling, P. J. Gierasch, G. S. Orton, P. L. Read, A. Sánchez-Lavega, A. P. Showman, A. A. Simon-Miller and A. R. Vasavada; 7. The stratosphere of Jupiter J. I. Moses, T. Fouchet, R. V. Yelle, A. J. Friedson, G. S. Orton, B. Bézard, P. Drossart, G. R. Gladstone, T. Kostiuk and T. A. Livengood; 8. Lessons from Shoemaker-Levy 9 about Jupiter and planetary impacts J. Harrington, I. de Pater, S. H. Brecht, D. Deming, V. Meadows, K. Zahnle and P. D. Nicholson; 9. Jupiter's thermosphere and ionosphere R. V. Yelle and S. Miller; 10. Jovian dust: streams, clouds and rings H. Krüger, M. Horányi, A. V. Krivov and A. L. Graps; 11. Jupiter's ring-moon system J. A. Burns, D. P. Simonelli, M. R. Showalter, D. P. Hamilton, C. C. Porco, H. Throop and L. W. Esposito; 12. Jupiter's outer satellites and trojans D. C. Jewitt, S. Sheppard and C. Porco; 13. Interior composition, structure and dynamics of the Galilean satellites G. Schubert, J. D. Anderson, T. Spohn and W. B. McKinnon; 14. The lithosphere and surface of Io A. S. McEwen, L. P. Keszthelyi, R. Lopes, P. M. Schenk and J. R. Spencer; 15. Geology of Europa R. Greeley, C. F. Chyba, J. W. Head III, T. B. McCord, W. B. McKinnon, R. T. Pappalardo and P. Figueredo; 16. Geology of Ganymede R. T. Pappalardo, G. C. Collins, J. W. Head III, P. Helfenstein, T. B. McCord, J. M. Moore, L. M. Procktor, P. M. Shenk and J. R. Spencer; 17. Callisto J. M. Moore, C. R. Chapman. E. B. Bierhaus, R

10 years of mapping the icy saturnian satellites

NASA Astrophysics Data System (ADS)

Roatsch, Thomas; Kersten, Elke; Matz, Klaus-Dieter; Porco, Carolyn

2014-05-01

anticipated scientific investigations at saturn, Space Science Re-view 115, 363-497. [2] Roatsch et al., 2006, Mapping of the icy Saturnian satellites: first results from Cassi-ni-ISS, Planetary Space Sciences 54, 1137-1145. [3] Archinal et al., 2011, Report of the IAU working group on cartographic coordinates and rotational elements: 2009. Celestial Mechanics and Dynamical Astronomy 109, 101-135. [4] Roatsch et al., 2009, Cartographic mapping of the icy satellites using ISS and VIMS data. In: Dougherty, M.K., Esposito, L.W., Krimigis, S.M. (Eds.), Saturn from Cassini-Huygens. Springer, NY, pp. 763-782. [5] Greeley and Batson, 1990, Planetary Mapping, Cambridge University Press, Cambridge.

Multiscale Geoarchaeological Approaches from the Laurentine Shore, Castelporziano, Lazio, Italy

NASA Astrophysics Data System (ADS)

Bicket, A. R.; Rendell, H. M.; Claridge, A.; Rose, P.; Brown, F. S. J.

2009-04-01

archaeological record to be discussed. Sedimentary petrology techniques allow the provenance and transportation dynamics of both the sand-sized and dust-sized sediments to be assessed. Furthermore this approach also enables an investigation of carbonate and iron oxide diagenetic cements, which are an important product of the long-term in situ weathering of the dune ridges' mineralogical assemblages, but is also a feature of short-term weathering of archaeological contexts. This work has implications for locations of interest to geoarchaeological surveys. There are also important implications for the mineralogy, provenance and preservation of luminescent minerals; and some form mineralogical/provenance analysis is recommended for all optical dating studies as a result. In summary, the geoarchaeological approach undertaken at Castelporziano allows the meso-scale human/environment interactions to be considered within the broader temporal scales of the late Quaternary. It also permits consideration within the macro-spatial scales of the Tiber Delta's development during the last 15-20ka within the context of eustatic sea level rise. REFERENCES LAMBECK, K., ANTONIOLI, F., PURCELL, A. & SILENZI, S. (2004a) Sea-level change along the Italian coast for the past 10,000 yr. Quaternary Science Reviews, 23, 1567-1598. LAMBECK, K., ANZIDEI, M., ANTONIOLI, F., BENINI, A. & ESPOSITO, A. (2004b) Sea level in Roman time in the Central Mediterranean and implications for recent change. Earth and Planetary Science Letters, 224, 563-575.

3D displacements maps of the L'Aquila earthquake by applying SISTEM method to GPS and ENVISAT and ALOS DInSAR data

NASA Astrophysics Data System (ADS)

Guglielmino, Francesco; Anzidei, Marco; Briole, Pierre; de Michele, Marcello; Elias, Panagiotis; Nunnari, Giuseppe; Puglisi, Giuseppe; Spata, Alessandro

2010-05-01

). We also analyzed ALOS PALSAR interferograms produced with images acquired along two different ascending tracks and relevant to the 3/7/2008 - 21/5/2009 time interval (track 638; tbline = 322 days; Bperp = 665 m ) and 2/3/2007 - 22/4/2009 time interval (track 639; tbline = 782 days; Bperp = 466 m ). In order to derive 3D surface motion maps, we apply the SISTEM method to the available geodetic dataset (both GPS and DInSAR). The SISTEM method performs an integration of GPS and DInSAR data for computing displacements on each point of the studied area. The SISTEM is based on elastic theory, and provides the complete 3D strain and the rigid body rotation tensors in the same solution. To achieve higher accuracy and get better the constraint of the 3D components of the displacements, we improved the standard formulation of SISTEM approach, based on a single DInSAR data, in order to take into account both ascending and descending interferograms and the DInSAR data acquired by different sensors(ALOS and ENVISAT). The SISTEM integration results show a complex kinematics, where the main movements (max westward movement of 165 mm associated with a max lowering of 260 mm) are recorded in the area between the surface evidence of the Paganica fault and Monticchio-fossa fault. These results, which provide both accurate and fine spatial characterization of ground deformation, are hence promising for future studies aimed at improving the knowledge of the kinematic of the Paganica fault and identification of additional faults responsible of the seismic sequence and that have contributed to the observed ground deformation. References. Anzidei, M., P. Baldi, A. Pesci, A. Esposito, A. Galvani, F. Loddo, P. Cristofoletti, A. Massucci, and S. Del Mese (2005), Geodetic deformation across the Central Apennines from GPS data in the time span 1999-2003, Ann. Geophys., 48(2), 259-271. Boschi, E., E. Guidoboni, G. Ferrrari, D. Mariotti, G. Valensise, and P. Gasperini (2000), Catalogue of strong

Is the April 6th 2009 L'Aquila earthquake a confirmation of the "seismic landscape" concept?

NASA Astrophysics Data System (ADS)

Blumetti, Anna Maria; Comerci, Valerio; Guerrieri, Luca; Michetti, Alessandro Maria; Serva, Leonello; Vittori, Eutizio

2010-05-01

-generated mountain fronts in Central Apennines (Central Italy); geomorphological features and seismotectonic implications. Earth Surface Processes and Landforms, 18, 203-223. Blumetti A.M. (1995) - Neotectonic investigations and evidence of paleo­seismicity in the epicentral area of the January-February 1703 Central Italy earthquakes. Bulletin of the American Association of Engineering Geologists, Special Volume n. 6: "Perspectives in Paleoseismology", Texas A&M University, Chapter 7, 83-100. Blumetti A.M., Guerrieri L. (2007) - Fault-generated mountain fronts and the identification of fault segments: implications for seismic hazard assessment. Boll. Soc. Geol. It. (Ital.J.Geosci.), 126 (2), 307-322. Blumetti, A.M., Comerci, V., Di Manna, P., Guerrieri L., Vittori E. (2009) - Geological effects induced by the L'Aquila earthquake (6 April 2009; ML=5.8) on the natural environment. Preliminary Report. 38 pp. http://www.apat.gov.it/site/_files/Inqua/2009_abruzzo_earthquake_report.pdf. Chiarabba, C. et al. (2009) - The 2009 L'Aquila (central Italy) Mw 6.3 earthquake: Main shock and aftershocks. Geophys. Res. Lett., 36, L18308, Michetti A.M., Audemard F., Marco S. (2005) - Future trends in paleoseismology: Integrated study of the seismic landscape as a vital tool in seismic hazard analyses, In: Michetti A.M., Audemard F., Marco S. (Editors), "Paleoseismology, integrated study of the Quaternary geological record for earthquake deformation and faulting", Special Issue, Tectonophysics, 408 (1-4), 3-21. Serva L. Blumetti A.M., Guerrieri L. & Michetti A. M. (2002) - The Apennine intermountain basins: the result of repeated strong earthquakes over a geological time interval. Boll. Soc. Geol. It. Special Volume 1, 939-946. Uria de Llanos A. (1703) - Relazione overo itinerario fatto dall'auditore Alfonso Uria del Llanos per riconoscere li danni causati dalli passati terremoi seguiti li 14 Gennaro e 2 Febraro M.DCCIII: Stamperi Gaetano Zenobj, Roma. Vittori E., G. Deiana, E. Esposito, L. Ferreli

PREFACE: Dynamic crossover phenomena in water and other glass-forming liquids Dynamic crossover phenomena in water and other glass-forming liquids

NASA Astrophysics Data System (ADS)

Chen, Sow-Hsin; Baglioni, Piero

2012-02-01

protein hydration water Francesco Mallamace, Carmelo Corsaro, Piero Baglioni, Emiliano Fratini and Sow-Hsin Chen Common features in the microscopic dynamics of hydration water on organic and inorganic surfacesE Mamontov, H O'Neill, Q Zhang, W Wang and D J Wesolowski Water dynamics as affected by interaction with biomolecules and change of thermodynamic state: a neutron scattering studyA Orecchini, A Paciaroni, C Petrillo, F Sebastiani, A De Francesco and F Sacchetti Temperature dependence of structure and density for D2O confined in MCM-41-SWilliam A Kamitakahara, Antonio Faraone, Kao-Hsiang Liu and Chung-Yuan Mou Density profile of water confined in cylindrical pores in MCM-41 silicaAlan K Soper Dynamic crossover in hydration water of curing cement paste: the effect of superplasticizerHua Li, Wei-Shan Chiang, Emiliano Fratini, Francesca Ridi, Francesco Bausi, Piero Baglioni, Madhu Tyagi and Sow-Hsin Chen Water confined in MCM-41: a mode coupling theory analysisP Gallo, M Rovere and S-H Chen Computer simulations of dynamic crossover phenomena in nanoconfined waterG B Suffritti, P Demontis, J Gulín-Gonźlez and M Masia Hydrophobic nanoconfinement suppresses fluctuations in supercooled waterE G Strekalova, M G Mazza, H E Stanley and G Franzese Other glass-forming liquids Quasi-elastic neutron scattering studies of the slow dynamics of supercooled and glassy aspirinYang Zhang, Madhusudan Tyagi, Eugene Mamontov and Sow-Hsin Chen Colloids Phase diagram of trivalent and pentavalent patchy particlesFlavio Romano, Eduardo Sanz, Piero Tartaglia and Francesco Sciortino Distinguishing the monomer to cluster phase transition in concentrated lysozyme solutions by studying the temperature dependence of the short-time dynamicsPéter Falus, Lionel Porcar, Emiliano Fratini, Wei-Ren Chen, Antonio Faraone, Kunlun Hong, Piero Baglioni and Yun Liu Contrast variation in spin-echo small angle neutron scatteringXin Li, Bin Wu, Yun Liu, Roger Pynn, Chwen-Yang Shew, Gregory S Smith, Kenneth W