Sample records for agreement ast 88-09616

  1. Photometric Periodicities of Be/X-Ray Pulsars in the Small Magellanic Cloud

    NASA Astrophysics Data System (ADS)

    Schmidtke, P. C.; Cowley, A. P.

    2005-11-01

    Analysis of the long-term photometric variability of seven Be/X-ray pulsar systems in the Small Magellanic Cloud has been carried out. We find that a variety of types of variability are present, including long-term irregular changes, periodic orbital outbursts due to interaction between the stars (weeks to months), low-amplitude quasi-periodic variations of the equatorial disk (days), and nonradial pulsations of the Be primary star (hours). This paper utilizes public domain data obtained by the MACHO Project, jointly funded by the US Department of Energy through the University of California, Lawrence Livermore National Laboratory, under contract W-7405-Eng-48, by the National Science Foundation through the Center for Particle Astrophysics of the University of California under cooperative agreement AST 88-09616, and by the Mount Stromlo and Siding Spring Observatory, part of the Australian National University.

  2. Synthesis, Biophysical, and Pharmacological Evaluation of the Melanocortin Agonist AST3-88: Modifications of Peptide Backbone at Trp 7 Position Lead to a Potent, Selective, and Stable Ligand of the Melanocortin 4 Receptor (MC4R)

    PubMed Central

    2015-01-01

    The melanocortin-3 (MC3R) and melanocortin-4 (MC4R) receptors are expressed in the brain and are implicated in the regulation of food intake and energy homeostasis. The endogenous agonist ligands for these receptors (α-, β-, γ-MSH and ACTH) are linear peptides with limited receptor subtype selectivity and metabolic stability, thus minimizing their use as probes to characterize the overlapping pharmacological and physiological functions of the melanocortin receptor subtypes. In the present study, an engineered template, in which the peptide backbone was modified by a heterocyclic reverse turn mimetic at the Trp7 residue, was synthesized using solid phase peptide synthesis and characterized by a β-galactosidase cAMP based reporter gene assay. The functional assay identified a ∼5 nM mouse MC4R agonist (AST3-88) with more than 50-fold selectivity over the mMC3R. Biophysical studies (2D 1H NMR spectroscopy and molecular dynamics) of AST3-88 identified a type VIII β-turn secondary structure spanning the pharmacophore domain stabilized by the intramolecular interactions between the side chains of the His and Trp residues. Enzymatic studies of AST3-88 revealed enhanced stability of AST3-88 over the α-MSH endogenous peptide in rat serum. Upon central administration of AST3-88 into rats, a decreased food intake response was observed. This is the first study to probe the in vivo physiological activity of this engineered peptide-heterocycle template. These findings advance the present knowledge of pharmacophore design for potent, selective, and metabolically stable melanocortin ligands. PMID:25141170

  3. 36 CFR 8.8 - Filing of labor agreements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Filing of labor agreements. 8... LABOR STANDARDS APPLICABLE TO EMPLOYEES OF NATIONAL PARK SERVICE CONCESSIONERS § 8.8 Filing of labor...), concessioners shall file with the Director of the National Park Service a copy of each labor agreement in effect...

  4. PhAst: A Flexible IDL Astronomical Image Viewer

    NASA Astrophysics Data System (ADS)

    Rehnberg, Morgan; Crawford, R.; Trueblood, M.; Mighell, K.

    2012-01-01

    We present near-Earth asteroid data analyzed with PhAst, a new IDL astronomical image viewer based on the existing application ATV. PhAst opens, displays, and analyzes an arbitrary number of FITS images. Analysis packages include image calibration, photometry, and astrometry (provided through an interface with SExtractor, SCAMP, and missFITS). PhAst has been designed to generate reports for Minor Planet Center reporting. PhAst is cross platform (Linux/Mac OSX/Windows for image viewing and Linux/Mac OSX for image analysis) and can be downloaded from the following website at NOAO: http://www.noao.edu/staff/mighell/phast/. Rehnberg was supported by the NOAO/KPNO Research Experiences for Undergraduates (REU) Program which is funded by the National Science Foundation Research Experiences for Undergraduates Program and the Department of Defense ASSURE program through Scientific Program Order No. 13 (AST-0754223) of the Cooperative Agreement No. AST-0132798 between the Association of Universities for Research in Astronomy (AURA) and the NSF.

  5. AST: A Simplified 3-item Tool for Managing Alcohol Withdrawal.

    PubMed

    Holzman, Samuel B; Rastegar, Darius A

    2016-01-01

    This study compared the Glasgow Modified Alcohol Withdrawal Scale (GMAWS) and a newly devised 3-item "Anxiety Sweats Tremor" Scale (AST) to the Revised Clinical Institute Withdrawal Assessment Scale (CIWA-Ar)-the standard of care for symptom-triggered management of alcohol withdrawal syndrome. Our study took place over 2 separate 1-week observational periods, and included 332 serial evaluations from 85 unique patients. All study participants were treated per hospital protocol based on CIWA-Ar, with supplemental scoring initially by GMAWS and later by AST in tandem. Internal consistency, interitem correlation, and operational characteristics were explored. Median CIWA-Ar score across both phases was 6 (range 0-13), with a median GMAWS score of 2 (range 0-5) and an AST score of 3 (range 0-7). The internal consistency of CIWA-Ar and GMAWS were both poor, with Cronbach alpha scores of 0.46 (n = 156) and 0.41 (n = 156), respectively. The internal consistency of the AST scale was significantly better, with a Cronbach alpha of 0.68 (n = 176). AST identified individuals with CIWA-Ar ≥8 with an area under the receiver-operating characteristic curve of 0.83 (95% confidence interval 0.77-0.89), compared with 0.81 (95% confidence interval 0.74-0.88) for GMAWS. An AST score of ≥3 (out of a possible 9) predicted CIWA-Ar ≥8, with a sensitivity of 93% and a specificity of 63%, whereas the GMAWS had a sensitivity and specificity of 100% and 12%, respectively, based on previously defined cut-offs. A simple 3-item scale demonstrated good internal consistency and reliably identified individuals experiencing significant alcohol withdrawal. This scale needs to be tested in other settings and among patients with a broader spectrum of withdrawal severity.

  6. AST Test: MedlinePlus Lab Test Information

    MedlinePlus

    ... page: https://medlineplus.gov/labtests/asttest.html AST Test To use the sharing features on this page, please enable JavaScript. What is an AST Test? AST (aspartate aminotransferase) is an enzyme that is ...

  7. AST: World Coordinate Systems in Astronomy

    NASA Astrophysics Data System (ADS)

    Berry, David S.; Warren-Smith, Rodney F.

    2014-04-01

    The AST library provides a comprehensive range of facilities for attaching world coordinate systems to astronomical data, for retrieving and interpreting that information in a variety of formats, including FITS-WCS, and for generating graphical output based on it. Core projection algorithms are provided by WCSLIB (ascl:1108.003) and astrometry is provided by the PAL (ascl:1606.002) and SOFA (ascl:1403.026) libraries. AST bindings are available in Python (pyast), Java (JNIAST) and Perl (Starlink::AST). AST is used as the plotting and astrometry library in DS9 and GAIA, and is distributed separately and as part of the Starlink software collection.

  8. PhAST: pharmacophore alignment search tool.

    PubMed

    Hähnke, Volker; Hofmann, Bettina; Grgat, Tomislav; Proschak, Ewgenij; Steinhilber, Dieter; Schneider, Gisbert

    2009-04-15

    We present a ligand-based virtual screening technique (PhAST) for rapid hit and lead structure searching in large compound databases. Molecules are represented as strings encoding the distribution of pharmacophoric features on the molecular graph. In contrast to other text-based methods using SMILES strings, we introduce a new form of text representation that describes the pharmacophore of molecules. This string representation opens the opportunity for revealing functional similarity between molecules by sequence alignment techniques in analogy to homology searching in protein or nucleic acid sequence databases. We favorably compared PhAST with other current ligand-based virtual screening methods in a retrospective analysis using the BEDROC metric. In a prospective application, PhAST identified two novel inhibitors of 5-lipoxygenase product formation with minimal experimental effort. This outcome demonstrates the applicability of PhAST to drug discovery projects and provides an innovative concept of sequence-based compound screening with substantial scaffold hopping potential. 2008 Wiley Periodicals, Inc.

  9. Expression and purification of a functional recombinant aspartate aminotransferase (AST) from Escherichia coli.

    PubMed

    Zou, Lihui; Zhao, Haijian; Wang, Daguang; Wang, Meng; Zhang, Chuanbao; Xiao, Fei

    2014-07-01

    Aspartate aminotransferase (AST; E.C. 2.6.1.1), a vitamin B6-dependent enzyme, preferentially promotes the mutual transformation of aspartate and α-ketoglutarate to oxaloacetate and glutamate. It plays a key role in amino acid metabolism and has been widely recommended as a biomarker of liver and heart damage. Our study aimed to evaluate the extensive preparation of AST and its application in quality control in clinical laboratories. We describe a scheme to express and purify the 6His-AST fusion protein. An optimized sequence coding AST was synthesized and transformed into Escherichia coli BL21 (DE3) strain for protein expression. Ideally, the fusion protein has a volumetric productivity achieving 900 mg/l cultures. After affinity chromatography, the enzyme activity of purified AST reached 150,000 U/L. Commutability assessment between the engineered AST and standard AST from Roche suggested that the engineered AST was the better candidate for the reference material. Moreover, the AST showed high stability during long-term storage at -20ºC. In conclusion, the highly soluble 6His-tagged AST can become a convenient tool for supplying a much better and cheaper standard or reference material for the clinical laboratory.

  10. 7 CFR 993.88 - Agents.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Agents. 993.88 Section 993.88 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE DRIED PRUNES PRODUCED IN CALIFORNIA Order...

  11. 7 CFR 993.88 - Agents.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Agents. 993.88 Section 993.88 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE DRIED PRUNES PRODUCED IN CALIFORNIA Order...

  12. 7 CFR 993.88 - Agents.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Agents. 993.88 Section 993.88 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE DRIED PRUNES PRODUCED IN CALIFORNIA Order...

  13. 7 CFR 993.88 - Agents.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Agents. 993.88 Section 993.88 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE DRIED PRUNES PRODUCED IN CALIFORNIA Order...

  14. 7 CFR 993.88 - Agents.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Agents. 993.88 Section 993.88 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE DRIED PRUNES PRODUCED IN CALIFORNIA Order...

  15. 7 CFR 966.88 - Agents.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Agents. 966.88 Section 966.88 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TOMATOES GROWN IN FLORIDA Order Regulating...

  16. AST Combustion Workshop: Diagnostics Working Group Report

    NASA Technical Reports Server (NTRS)

    Locke, Randy J.; Hicks, Yolanda R.; Hanson, Ronald K.

    1996-01-01

    A workshop was convened under NASA's Advanced Subsonics Technologies (AST) Program. Many of the principal combustion diagnosticians from industry, academia, and government laboratories were assembled in the Diagnostics/Testing Subsection of this workshop to discuss the requirements and obstacles to the successful implementation of advanced diagnostic techniques to the test environment of the proposed AST combustor. The participants, who represented the major relevant areas of advanced diagnostic methods currently applied to combustion and related fields, first established the anticipated AST combustor flowfield conditions. Critical flow parameters were then examined and prioritized as to their importance to combustor/fuel injector design and manufacture, environmental concerns, and computational interests. Diagnostic techniques were then evaluated in terms of current status, merits and obstacles for each flow parameter. All evaluations are presented in tabular form and recommendations are made on the best-suited diagnostic method to implement for each flow parameter in order of applicability and intrinsic value.

  17. Efficacy of AST-120 in dogs with chronic idiopathic enteropathies.

    PubMed

    Volkmann, M; Wirtherle, N C; Beddies, G F; Kohn, B

    2013-01-01

    Chronic idiopathic enteropathies (CIE) in dogs are complex diseases of unknown origin. AST-120 is a spherical carbon adsorbent preparation with a high adsorption ability for low molecular substances. Evaluation of the clinical efficacy of AST-120 in dogs with CIE. Ten client-owned dogs with mild (n = 7) to moderate (n = 3) CIE. Explorative, prospective, randomized, placebo-controlled, double-blinded pilot study. Dogs with chronic diarrhea and no or insufficient response to an elimination diet were included. The dogs received either AST-120 (n = 5) or placebo (n = 5) for a duration of 21 days. The canine inflammatory bowel disease activity index (CIBDAI) was used to assess disease severity at baseline and clinical outcome after 3 weeks of treatment. Furthermore, changes in body weight and the parameters stool consistency and frequency were compared within and between groups. The mean CIBDAI score decreased from 5.6 (SD 1.5) to 2.0 (SD 1.2) in the AST-120 group (P = .125) and from 4.8 (SD .8) to 3.6 (SD 2.3) in the placebo group (P = .688). Compared with baseline, posttreatment CIBDAI scores decreased more than 60% in 4/5 dogs treated with AST-120 and in 1/5 dogs treated with placebo (P = .206). Changes in CIBDAI scores, body weights, stool consistency, and frequency within and between groups did not achieve statistical significance after 3 weeks of treatment. No adverse effects of AST-120 were noted. This study investigated potential efficacy of AST-120 as an alternative therapy in dogs with mild-to-moderate CIE. Copyright © 2013 by the American College of Veterinary Internal Medicine.

  18. Hadronic molecular states from the Kbar{K}^{ast} interaction

    NASA Astrophysics Data System (ADS)

    Lü, Pei-Liang; He, Jun

    2016-12-01

    In this work, the Kbar{K}^{ast} interaction is studied in a quasipotential Bethe-Salpeter equation approach combined with the one-boson-exchange model. With the help of the hidden-gauge Lagrangian, the exchanges of pseudoscalar mesons (π and η) and vector mesons (ρ, ω and φ) are considered to describe the Kbar{K}^{ast} interaction. Besides the direct vector-meson exchange which can be related to the Weinberg-Tomozawa term, pseudoscalar-meson exchanges also play important roles in the mechanism of the Kbar{K}^{ast} interaction. The poles of scattering amplitude are searched to find the molecular states produced from the Kbar{K}^{ast} interaction. In the case of quantum number IG(J^{PC}) = 0+(1^{++}), a pole is found with a reasonable cutoff, which can be related to the f1(1285) in experiment. Another bound state with 0-(1^{+-}) is also produced from the Kbar{K}^{ast} interaction, which can be related to the h1(1380). In the isovector sector, the interaction is much weaker and a bound state with 1+(1+) relevant to the b1(1235) is produced but at a larger cutoff. Our results suggest that in the hadronic molecular state picture the f1(1285) and b1(1235) are the strange partners of the X(3872) and Zc(3900), respectively.

  19. The AST3 controlling and operating software suite for automatic sky survey

    NASA Astrophysics Data System (ADS)

    Hu, Yi; Shang, Zhaohui; Ma, Bin; Hu, Keliang

    2016-07-01

    We have developed a specialized software package, called ast3suite, to achieve the remote control and automatic sky survey for AST3 (Antarctic Survey Telescope) from scratch. It includes several daemon servers and many basic commands. Each program does only one single task, and they work together to make AST3 a robotic telescope. A survey script calls basic commands to carry out automatic sky survey. Ast3suite was carefully tested in Mohe, China in 2013 and has been used at Dome, Antarctica in 2015 and 2016 with the real hardware for practical sky survey. Both test results and practical using showed that ast3suite had worked very well without any manual auxiliary as we expected.

  20. AST/ASTS workshop on increasing organ donation in the United States: creating an "arc of change" from removing disincentives to testing incentives.

    PubMed

    Salomon, D R; Langnas, A N; Reed, A I; Bloom, R D; Magee, J C; Gaston, R S

    2015-05-01

    The American Society of Transplantation (AST) and American Society of Transplant Surgeons (ASTS) convened a workshop on June 2-3, 2014, to explore increasing both living and deceased organ donation in the United States. Recent articles in the lay press on illegal organ sales and transplant tourism highlight the impact of the current black market in kidneys that accompanies the growing global organ shortage. We believe it important not to conflate the illegal market for organs, which we reject in the strongest possible terms, with the potential in the United States for concerted action to remove all remaining financial disincentives for donors and critically consider testing the impact and acceptability of incentives to increase organ availability in the United States. However, we do not support any trials of direct payments or valuable considerations to donors or families based on a process of market-assigned values of organs. This White Paper represents a summary by the authors of the deliberations of the Incentives Workshop Group and has been approved by both AST and ASTS Boards. © Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.

  1. AstRoMap European Astrobiology Roadmap

    PubMed Central

    Horneck, Gerda; Westall, Frances; Grenfell, John Lee; Martin, William F.; Gomez, Felipe; Leuko, Stefan; Lee, Natuschka; Onofri, Silvano; Tsiganis, Kleomenis; Saladino, Raffaele; Pilat-Lohinger, Elke; Palomba, Ernesto; Harrison, Jesse; Rull, Fernando; Muller, Christian; Strazzulla, Giovanni; Brucato, John R.; Rettberg, Petra; Capria, Maria Teresa

    2016-01-01

    Abstract The European AstRoMap project (supported by the European Commission Seventh Framework Programme) surveyed the state of the art of astrobiology in Europe and beyond and produced the first European roadmap for astrobiology research. In the context of this roadmap, astrobiology is understood as the study of the origin, evolution, and distribution of life in the context of cosmic evolution; this includes habitability in the Solar System and beyond. The AstRoMap Roadmap identifies five research topics, specifies several key scientific objectives for each topic, and suggests ways to achieve all the objectives. The five AstRoMap Research Topics are • Research Topic 1: Origin and Evolution of Planetary Systems• Research Topic 2: Origins of Organic Compounds in Space• Research Topic 3: Rock-Water-Carbon Interactions, Organic Synthesis on Earth, and Steps to Life• Research Topic 4: Life and Habitability• Research Topic 5: Biosignatures as Facilitating Life Detection It is strongly recommended that steps be taken towards the definition and implementation of a European Astrobiology Platform (or Institute) to streamline and optimize the scientific return by using a coordinated infrastructure and funding system. Key Words: Astrobiology roadmap—Europe—Origin and evolution of life—Habitability—Life detection—Life in extreme environments. Astrobiology 16, 201–243. PMID:27003862

  2. Reliability and Validity of Korean Version of Apraxia Screen of TULIA (K-AST).

    PubMed

    Kim, Soo Jin; Yang, You-Na; Lee, Jong Won; Lee, Jin-Youn; Jeong, Eunhwa; Kim, Bo-Ram; Lee, Jongmin

    2016-10-01

    To evaluate the reliability and validity of Korean version of AST (K-AST) as a bedside screening test of apraxia in patients with stroke for early and reliable detection. AST was translated into Korean, and the translated version received authorization from the author of AST. The performances of K-AST in 26 patients (21 males, 5 females; mean age 65.42±17.31 years) with stroke (23 ischemic, 3 hemorrhagic) were videotaped. To test the reliability and validity of K-AST, the recorded performances were assessed by two physiatrists and two occupational therapists twice at a 1-week interval. The patient performances at admission in Korean version of Mini-Mental State Examination (K-MMSE), self-care and transfer categories of Functional Independence Measure (FIM), and motor praxis area of Loewenstein Occupational Therapy Cognitive Assessment, the second edition (LOTCA-II) were also evaluated. Scores of motor praxis area of LOTCA-II was used to assess the validity of K-AST. Inter-rater reliabilities were 0.983 (p<0.001) at the first assessment and 0.982 (p<0.001) at the second assessment. For intra-rater (test-retest) reliabilities, the values of four raters were 0.978 (p<0.001), 0.957 (p<0.001), 0.987 (p<0.001), and 0.977 (p<0.001). K-AST showed significant correlation (r=0.758, p<0.001) with motor praxis area of LOTCA-II test. K-AST also showed positive correlations with the total FIM score (r=0.694, p<0.001), the selfcare category of FIM (r=0.705, p<0.001) and the transfer category of FIM (r=653, p<0.001). K-AST is a reliable and valid test for bedside screening of apraxia.

  3. AST Composite Wing Program: Executive Summary

    NASA Technical Reports Server (NTRS)

    Karal, Michael

    2001-01-01

    The Boeing Company demonstrated the application of stitched/resin infused (S/RFI) composite materials on commercial transport aircraft primary wing structures under the Advanced Subsonic technology (AST) Composite Wing contract. This report describes a weight trade study utilizing a wing torque box design applicable to a 220-passenger commercial aircraft and was used to verify the weight savings a S/RFI structure would offer compared to an identical aluminum wing box design. This trade study was performed in the AST Composite Wing program, and the overall weight savings are reported. Previous program work involved the design of a S/RFI-base-line wing box structural test component and its associated testing hardware. This detail structural design effort which is known as the "semi-span" in this report, was completed under a previous NASA contract. The full-scale wing design was based on a configuration for a MD-90-40X airplane, and the objective of this structural test component was to demonstrate the maturity of the S/RFI technology through the evaluation of a full-scale wing box/fuselage section structural test. However, scope reductions of the AST Composite Wing Program pre-vented the fabrication and evaluation of this wing box structure. Results obtained from the weight trade study, the full-scale test component design effort, fabrication, design development testing, and full-scale testing of the semi-span wing box are reported.

  4. 7 CFR 905.88 - Personal liability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Personal liability. 905.88 Section 905.88 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... responsible, either individually or jointly with others, in any way whatsoever, to any handler or to any other...

  5. 7 CFR 983.88 - Suspension or termination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Suspension or termination. 983.88 Section 983.88 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE PISTACHIOS GROWN IN CALIFORNIA...

  6. M4AST - A Tool for Asteroid Modelling

    NASA Astrophysics Data System (ADS)

    Birlan, Mirel; Popescu, Marcel; Irimiea, Lucian; Binzel, Richard

    2016-10-01

    M4AST (Modelling for asteroids) is an online tool devoted to the analysis and interpretation of reflection spectra of asteroids in the visible and near-infrared spectral intervals. It consists into a spectral database of individual objects and a set of routines for analysis which address scientific aspects such as: taxonomy, curve matching with laboratory spectra, space weathering models, and mineralogical diagnosis. Spectral data were obtained using groundbased facilities; part of these data are precompiled from the literature[1].The database is composed by permanent and temporary files. Each permanent file contains a header and two or three columns (wavelength, spectral reflectance, and the error on spectral reflectance). Temporary files can be uploaded anonymously, and are purged for the property of submitted data. The computing routines are organized in order to accomplish several scientific objectives: visualize spectra, compute the asteroid taxonomic class, compare an asteroid spectrum with similar spectra of meteorites, and computing mineralogical parameters. One facility of using the Virtual Observatory protocols was also developed.A new version of the service was released in June 2016. This new release of M4AST contains a database and facilities to model more than 6,000 spectra of asteroids. A new web-interface was designed. This development allows new functionalities into a user-friendly environment. A bridge system of access and exploiting the database SMASS-MIT (http://smass.mit.edu) allows the treatment and analysis of these data in the framework of M4AST environment.Reference:[1] M. Popescu, M. Birlan, and D.A. Nedelcu, "Modeling of asteroids: M4AST," Astronomy & Astrophysics 544, EDP Sciences, pp. A130, 2012.

  7. Coastal Atmosphere and Sea Time Series (CoASTS)

    NASA Technical Reports Server (NTRS)

    Hooker, Stanford B. (Editor); Firestone, Elaine R. (Editor); Zibordi, Giuseppe; Berthon, Jean-Francoise; Doyle, John P.; Grossi, Stefania; vanderLinde, Dirk; Targa, Cristina; Alberotanza, Luigi; McClain, Charles R. (Technical Monitor)

    2002-01-01

    The Coastal Atmosphere and Sea Time Series (CoASTS) Project aimed at supporting ocean color research and applications, from 1995 up to the time of publication of this document, has ensured the collection of a comprehensive atmospheric and marine data set from an oceanographic tower located in the northern Adriatic Sea. The instruments and the measurement methodologies used to gather quantities relevant for bio-optical modeling and for the calibration and validation of ocean color sensors, are described. Particular emphasis is placed on four items: (1) the evaluation of perturbation effects in radiometric data (i.e., tower-shading, instrument self-shading, and bottom effects); (2) the intercomparison of seawater absorption coefficients from in situ measurements and from laboratory spectrometric analysis on discrete samples; (3) the intercomparison of two filter techniques for in vivo measurement of particulate absorption coefficients; and (4) the analysis of repeatability and reproducibility of the most relevant laboratory measurements carried out on seawater samples (i.e., particulate and yellow substance absorption coefficients, and pigment and total suspended matter concentrations). Sample data are also presented and discussed to illustrate the typical features characterizing the CoASTS measurement site in view of supporting the suitability of the CoASTS data set for bio-optical modeling and ocean color calibration and validation.

  8. Advanced Supersonic Technology concept AST-100 characteristics developed in a baseline-update study

    NASA Technical Reports Server (NTRS)

    Baber, H. T., Jr.; Swanson, E. E.

    1976-01-01

    The advanced supersonic technology configuration, AST-100, is described. The combination of wing thickness reduction, nacelle recontouring for minimum drag at cruise, and the use of the horizontal tail to produce lift during climb and cruise resulted in an increase in maximum lift-to-drag ratio. Lighter engines and lower fuel weight associated with this resizing result in a six percent reduction in takeoff gross weight. The AST-100 takeoff maximum effective perceived noise at the runway centerline and sideline measurement stations was 114.4 decibels. Since 1.5-decibels tradeoff is available from the approach noise, the required engine noise supression is 4.9 decibels. The AST-100 largest maximum overpressure would occur during transonic climb acceleration when the aircraft was at relatively low altitude. Calculated standard +8 C day range of the AST-100, with a 292 passenger payload, is 7348 km (3968 n.mi). Fuel price is the largest contributor to direct operating cost. However, if the AST-100 were flown subsonically (M = 0.9), direct operating costs would increase approximately 50 percent because of time related costs.

  9. Effects of an AST program on US titanium story

    NASA Technical Reports Server (NTRS)

    Fitzsimmons, R. D.

    1980-01-01

    The singular importance of titanium as the primary structural material for an efficient advanced supersonic transport (AST) is outlined. The advantages of titanium over other metals are shown to apply to future subsonic aircraft as well as for supersonic designs. The cost problem of titanium is addressed and shown to be markedly reduced by the emerging technologies of superplastic forming/diffusion bonding sandwich, hot isostatic pressing of titanium powders, and isothermal forgings if demonstration programs should validate preliminary findings. The impact of a U.S. AST program on the United States titanium supply and demand picture is postulated.

  10. AST1306, a potent EGFR inhibitor, antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance.

    PubMed

    Zhang, Hui; Wang, Yi-Jun; Zhang, Yun-Kai; Wang, De-Shen; Kathawala, Rishil J; Patel, Atish; Talele, Tanaji T; Chen, Zhe-Sheng; Fu, Li-Wu

    2014-08-01

    AST1306, an inhibitor of EGFR and ErbB2, is currently in phase I of clinical trials. We evaluated the effect of AST306 on the reversal of multidrug resistance (MDR) induced by ATP-binding cassette (ABC) transporters. We found that AST1306 significantly sensitized the ABC subfamily G member 2 (ABCG2)-overexpressing cells to ABCG2 substrate chemotherapeutics. AST1306 significantly increased intracellular accumulation of [(3)H]-mitoxantrone in ABCG2-overexpressing cells by blocking ABCG2 efflux function. Moreover, AST1306 stimulated the ATPase activity of ABCG2. Homology modeling predicted the binding conformation of AST1306 to be within the transmembrane region of ABCG2. In conclusion, AST1306 could notably reverse ABCG2-mediated MDR. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  11. 7 CFR 956.88 - Effect of termination or amendment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Effect of termination or amendment. 956.88 Section 956.88 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE SWEET...

  12. Precision holography for N={2}^{\\ast } on S 4 from type IIB supergravity

    NASA Astrophysics Data System (ADS)

    Bobev, Nikolay; Gautason, Friðrik Freyr; van Muiden, Jesse

    2018-04-01

    We find a new supersymmetric solution of type IIB supergravity which is holographically dual to the planar limit of the four-dimensional N={2}^{\\ast } supersymmetric Yang-Mills theory on S 4. We study a probe fundamental string in this background which is dual to a supersymmetric Wilson loop in the N={2}^{\\ast } theory. Using holography we calculate the expectation value of this line operator to leading order in the 't Hooft coupling. The result is a non-trivial function of the mass parameter of the N={2}^{\\ast } theory that precisely matches the result from supersymmetric localization.

  13. Deleterious vascular effects of indoxyl sulfate and reversal by oral adsorbent AST-120.

    PubMed

    Six, Isabelle; Gross, Priscilla; Rémond, Mathieu C; Chillon, Jean Marc; Poirot, Sabrina; Drueke, Tilman B; Massy, Ziad A

    2015-11-01

    In chronic kidney disease (CKD), blood vessels are permanently exposed to uremic toxins such as indoxyl sulfate (IS). We hypothesized that IS could alter vascular tone and that reducing its serum concentration could be beneficial. We studied acute and longer-term effects of IS and AST-120, an oral charcoal adsorbent, on vascular reactivity, endothelium integrity and expression of adhesion molecules VCAM-1 and ICAM-1 in aortic rings of normal and uremic wild type (WT) mice in vitro, and the cardiovascular effects of AST-120 in both WT and apoE-/- mice with CKD in vivo. In vitro, 1.0 mM IS acutely reduced vascular relaxation (64% for IS 1.0 mM vs. 80% for control, p < 0.05). The effect was more marked after 4 days exposure (39% for IS 1.0 mM 4 days; p < 0.001, prolonged vs. acute exposure), and was associated with endothelial cell loss and upregulation of ICAM-1/VCAM-1 expression. In vitro, AST-120 restored normal vascular function and prevented IS induced endothelial cell loss and ICAM-1/VCAM-1 upregulation. In vivo, AST-120 treatment of CKD mice (1) improved vascular relaxation (72% vs. 48% maximal relaxation in treated vs. untreated mice, p < 0.001), (2) reduced aortic VCAM-1 and ICAM-1 expression, (3) decreased aorta systolic expansion rate (9 ± 3% CKD vs. 14 ± 3% CKD + AST-120, p < 0.02), and (4) prevented the increase in pulse wave velocity (3.56 ± 0.17 m/s CKD vs. 3.10 ± 0.08 m/s CKD + AST-120, p < 0.006). Similar changes were observed in apoE-/- mice. IS appears to be an important contributor to the vascular dysfunction associated with CKD. AST-120 treatment ameliorates this dysfunction, possibly via a decrease in serum IS concentration. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  14. The genetic architecture of liver enzyme levels: GGT, ALT and AST.

    PubMed

    van Beek, Jenny H D A; de Moor, Marleen H M; de Geus, Eco J C; Lubke, Gitta H; Vink, Jacqueline M; Willemsen, Gonneke; Boomsma, Dorret I

    2013-07-01

    High levels of liver enzymes GGT, ALT and AST are predictive of disease and all-cause mortality and can reflect liver injury, fatty liver and/or oxidative stress. Variation in GGT, ALT and AST levels is heritable. Moderation of the heritability of these liver enzymes by age and sex has not often been explored, and it is not clear to what extent non-additive genetic and shared environmental factors may play a role. To examine the genetic architecture of GGT, ALT and AST, plasma levels were assessed in a large sample of twins, their siblings, parents and spouses (N = 8,371; age range 18-90). For GGT and ALT, but not for AST, genetic structural equation modeling showed evidence for quantitative sex differences in the genetic architecture. There was no evidence for qualitative sex differences, i.e. the same genes were expressed in males and females. Both additive and non-additive genetic factors were important for GGT in females (total heritability h(2) 60 %) and AST in both sexes (total h(2) 43 %). The heritability of GGT in males and ALT for both sexes was due to additive effects only (GGT males 30 %; ALT males 40 %, females 22 %). Evidence emerged for shared environmental factors influencing GGT in the male offspring generation (variance explained 28 %). Thus, the same genes influence liver enzyme levels across sex and age, but their relative contribution to the variation in GGT and ALT differs in males and females and for GGT across age. Given adequate sample sizes these results suggest that genome-wide association studies may result in the detection of new susceptibility loci for liver enzyme levels when pooling results over sex and age.

  15. The First Release of the AST3-1 Point Source Catalogue from Dome A, Antarctica

    NASA Astrophysics Data System (ADS)

    Ma, Bin; Shang, Zhaohui; Hu, Yi; Hu, Keliang; Liu, Qiang; Ashley, Michael C. B.; Cui, Xiangqun; Du, Fujia; Fan, Dongwei; Feng, Longlong; Huang, Fang; Gu, Bozhong; He, Boliang; Ji, Tuo; Li, Xiaoyan; Li, Zhengyang; Liu, Huigen; Tian, Qiguo; Tao, Charling; Wang, Daxing; Wang, Lifan; Wang, Songhu; Wang, Xiaofeng; Wei, Peng; Wu, Jianghua; Xu, Lingzhe; Yang, Shihai; Yang, Ming; Yang, Yi; Yu, Ce; Yuan, Xiangyan; Zhou, Hongyan; Zhang, Hui; Zhang, Xueguang; Zhang, Yi; Zhao, Cheng; Zhou, Jilin; Zhu, Zong-Hong

    2018-05-01

    The three Antarctic Survey Telescopes (AST3) aim to carry out time domain imaging survey at Dome A, Antarctica. The first of the three telescopes (AST3-1) was successfully deployed on January 2012. AST3-1 is a 500 mm aperture modified Schmidt telescope with a 680 mm diameter primary mirror. AST3-1 is equipped with a SDSS i filter and a 10k × 10k frame transfer CCD camera, reduced to 5k × 10k by electronic shuttering, resulting in a 4.3 deg2 field-of-view. To verify the capability of AST3-1 for a variety of science goals, extensive commissioning was carried out between March and May 2012. The commissioning included a survey covering 2000 deg2 as well as the entire Large and Small Magellanic Clouds. Frequent repeated images were made of the center of the Large Magellanic Cloud, a selected exoplanet transit field, and fields including some Wolf-Rayet stars. Here we present the data reduction and photometric measurements of the point sources observed by AST3-1. We have achieved a survey depth of 19.3 mag in 60 s exposures with 5 mmag precision in the light curves of bright stars. The facility achieves sub-mmag photometric precision under stable survey conditions, approaching its photon noise limit. These results demonstrate that AST3-1 at Dome A is extraordinarily competitive in time-domain astronomy, including both quick searches for faint transients and the detection of tiny transit signals.

  16. Raman spectroscopy of glasses in the As-Te system

    NASA Astrophysics Data System (ADS)

    Tverjanovich, A.; Rodionov, K.; Bychkov, E.

    2012-06-01

    For the first time, the Raman spectra of AsxTe1-x glasses, 0.2≤x≤0.6, have been measured over the entire glass-forming range. The spectra exhibit three broad spectral features attributed to vibrations of structural units having Te-Te, As-Te and As-As bonds. The observed chemical disorder in the glasses is discussed on the basis of partial bond fractions derived from the integrated intensity of the Raman modes. The underlying structural model suggests a dissociation of AsTe- or As2Te3-related units in the glass melt. The spectra of glasses quenched from different temperatures, as well as those of the annealed vitreous alloys, are consistent with predictions of the model.

  17. Aspartate Aminotransferase (AST/GOT) and Alanine Aminotransferase (ALT/GPT) Detection Techniques

    PubMed Central

    Huang, Xing-Jiu; Choi, Yang-Kyu; Im, Hyung-Soon; Yarimaga, Oktay; Yoon, Euisik; Kim, Hak-Sung

    2006-01-01

    The levels of aspartate aminotransferase (AST/GOT) and alanine aminotransferase (ALT/GPT) in serum can help people diagnose body tissues especially the heart and the liver are injured or not. This article provides a comprehensive review of research activities that concentrate on AST/GOT and ALT/GPT detection techniques due to their clinical importance. The detection techniques include colorimetric, spectrophotometric, chemiluminescence, chromatography, fluorescence and UV absorbance, radiochemical, and electrochemical techniques. We devote the most attention on experimental principle. In some methods a few representative devices and important conclusions are presented.

  18. DynAstVO : a Europlanet database of NEA orbits

    NASA Astrophysics Data System (ADS)

    Desmars, J.; Thuillot, W.; Hestroffer, D.; David, P.; Le Sidaner, P.

    2017-09-01

    DynAstVO is a new orbital database developed within the Europlanet 2020 RI and the Virtual European Solar and Planetary Access (VESPA) frameworks. The database is dedicated to Near-Earth asteroids and provide parameters related to orbits: osculating elements, observational information, ephemeris through SPICE kernel, and in particular, orbit uncertainty and associated covariance matrix. DynAstVO is daily updated on a automatic process of orbit determination on the basis of the Minor Planet Electronic Circulars that reports new observations or the discover of a new asteroid. This database conforms to EPN-TAP environment and is accessible through VO protocols and on the VESPA portal web access (http://vespa.obspm.fr/). A comparison with other classical databases such as Astorb, MPCORB, NEODyS and JPL is also presented.

  19. Incremental Predictive Value of Serum AST-to-ALT Ratio for Incident Metabolic Syndrome: The ARIRANG Study

    PubMed Central

    Ahn, Song Vogue; Baik, Soon Koo; Cho, Youn zoo; Koh, Sang Baek; Huh, Ji Hye; Chang, Yoosoo; Sung, Ki-Chul; Kim, Jang Young

    2016-01-01

    Aims The ratio of aspartate aminotransferase (AST) to alanine aminotransferase (ALT) is of great interest as a possible novel marker of metabolic syndrome. However, longitudinal studies emphasizing the incremental predictive value of the AST-to-ALT ratio in diagnosing individuals at higher risk of developing metabolic syndrome are very scarce. Therefore, our study aimed to evaluate the AST-to-ALT ratio as an incremental predictor of new onset metabolic syndrome in a population-based cohort study. Material and Methods The population-based cohort study included 2276 adults (903 men and 1373 women) aged 40–70 years, who participated from 2005–2008 (baseline) without metabolic syndrome and were followed up from 2008–2011. Metabolic syndrome was defined according to the harmonized definition of metabolic syndrome. Serum concentrations of AST and ALT were determined by enzymatic methods. Results During an average follow-up period of 2.6-years, 395 individuals (17.4%) developed metabolic syndrome. In a multivariable adjusted model, the odds ratio (95% confidence interval) for new onset of metabolic syndrome, comparing the fourth quartile to the first quartile of the AST-to-ALT ratio, was 0.598 (0.422–0.853). The AST-to-ALT ratio also improved the area under the receiver operating characteristic curve (AUC) for predicting new cases of metabolic syndrome (0.715 vs. 0.732, P = 0.004). The net reclassification improvement of prediction models including the AST-to-ALT ratio was 0.23 (95% CI: 0.124–0.337, P<0.001), and the integrated discrimination improvement was 0.0094 (95% CI: 0.0046–0.0143, P<0.001). Conclusions The AST-to-ALT ratio independently predicted the future development of metabolic syndrome and had incremental predictive value for incident metabolic syndrome. PMID:27560931

  20. Generating a Magellanic star cluster catalog with ASteCA

    NASA Astrophysics Data System (ADS)

    Perren, G. I.; Piatti, A. E.; Vázquez, R. A.

    2016-08-01

    An increasing number of software tools have been employed in the recent years for the automated or semi-automated processing of astronomical data. The main advantages of using these tools over a standard by-eye analysis include: speed (particularly for large databases), homogeneity, reproducibility, and precision. At the same time, they enable a statistically correct study of the uncertainties associated with the analysis, in contrast with manually set errors, or the still widespread practice of simply not assigning errors. We present a catalog comprising 210 star clusters located in the Large and Small Magellanic Clouds, observed with Washington photometry. Their fundamental parameters were estimated through an homogeneous, automatized and completely unassisted process, via the Automated Stellar Cluster Analysis package ( ASteCA). Our results are compared with two types of studies on these clusters: one where the photometry is the same, and another where the photometric system is different than that employed by ASteCA.

  1. 2 CFR 200.88 - Simplified acquisition threshold.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Simplified acquisition threshold. 200.88... acquisition threshold. Simplified acquisition threshold means the dollar amount below which a non-Federal... threshold. The simplified acquisition threshold is set by the Federal Acquisition Regulation at 48 CFR...

  2. Translation and cultural adaptation of the Aguado Syntax Test (AST) into Brazilian Portuguese.

    PubMed

    Baggio, Gustavo Inheta; Hage, Simone Rocha de Vasconcellos

    2017-12-07

    To perform the translation and cultural adaptation of the Aguado Syntax Test (AST) into Brazilian Portuguese considering the linguistic and cultural reality of the language. The AST assesses the early morphosyntactic development in children aged 3 to 7 in terms of understanding and expression of various types of structures such as sentences, pronouns, verbal voices, comparisons, prepositions and verbal desinence as to number, mode and tense. The process of translation and cultural adaptation followed four steps: 1) preparation of two translations; 2) synthesis of consensual translations; 3) backtranslation; and 4) verification of equivalence between the initial translations and backtranslations that resulted in the final translated version. The whole process of translation and cultural adaptation revealed the presence of equivalence and reconciliation of the translated items and an almost complete semantic equivalence between the two translations and the absence of consistent translation difficulties. The AST was translated and culturally adapted into Brazilian Portuguese, constituting the first step towards validation and standardization of the test.

  3. Decay {B to K^ast(to Kπ)ℓ+ ℓ-} in Covariant Quark Model

    NASA Astrophysics Data System (ADS)

    Dubnička, S.; Dubničková, A. Z.; Habyl, N.; Ivanov, M. A.; Liptaj, A.; Nurbakova, G. S.

    2016-03-01

    Our article is devoted to the study of the rare {B to K^ast ℓ^+ℓ^-} decay where {ℓ=e,μ,τ}. We compute the relevant form factors in the framework of the covariant quark model with infrared confinement in the full kinematical momentum transfer region. The calculated form factors are used to evaluate branching fractions and polarization observables in the cascade decay {B to K^ast(to Kπ)ℓ^+ℓ^-}. We compare the obtained results with available experimental data and the results from other theoretical approaches.

  4. Research on scheduling of robotic transient survey for Antarctic Survey Telescopes (AST3)

    NASA Astrophysics Data System (ADS)

    Liu, Qiang; Wei, Peng; Shang, Zhao-Hui; Ma, Bin; Hu, Yi

    2018-01-01

    Antarctic Survey Telescopes (AST3) are designed to be fully robotic telescopes at Dome A, Antarctica, which aim for highly efficient time-domain sky surveys as well as rapid response to special transient events (e.g., gamma-ray bursts, near-Earth asteroids, supernovae, etc.). Unlike traditional observations, a well-designed real-time survey scheduler is needed in order to implement an automatic survey in a very efficient, reliable and flexible way for the unattended telescopes. We present a study of the survey strategy for AST3 and implementation of its survey scheduler, which is also useful for other survey projects.

  5. Suicide inactivation of rat liver aryl sulfotransferase IV (AST IV) by the sulfuric acid ester of N-hydroxy-2-acetylaminofluorene (NOH-AAF)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ringer, D.P.; Norton, T.R.; Self, R.R.

    Rat liver NOH-AAf sulfotransferase activity is mediated by AST IV and causes the bioactivation of NOH-AAF to a highly reactive, mutagenic sulfuric acid ester form which putatively has a role in inducing liver cancer. Unexpectedly, AAF has been found to decrease liver NOH-AAF sulfotransferase activity in dietary protocols used to induce hepatocarcinogenesis. The authors have thus examined reaction-product, suicide inactivation of AST IV as a possible mechanism for the loss in sulfotransferase activity. In initial experiments, purified AST IV was found to undergo a PAPS-dependent binding with ({sup 14}C)-NOH-AAF. Alkaline hydrolysis and C18-HPLC analysis of the AST IV:AAF conjugates revealedmore » that linkage primarily involved cysteine and methionine residues of AST IV. Experiments testing the effect of pretreatment of AST IV with NOH-AAF upon subsequent assay of sulfotransferase activity, showed that there was a NOH-AAF and PAPS dependent loss in AST IV sulfotransferase activity. These results demonstrate the highly reactive, sulfuric acid ester of NOH-AAF can covalently link with AST IV causing suicide inactivation of the enzyme, and suggests that it deserves consideration as an in vivo mechanism for loss of NOH-AAF sulfotransferase activity.« less

  6. Ada Compiler Validation Summary Report. Certificate Number: 921004W1. 11281, Verdix Corporation VADS System V/386/486 VAda-110-3232, Version 6.1, AST Premium 486 under UNIX System V, Release 4.0.

    DTIC Science & Technology

    1992-11-18

    Rev. 2-89) Prescribed by ANSI Std. 239-128 AVr Control Number: AVF-VSR-542-1092 Date VSR Complete: 18 November 1992 92-06-23- vRx Ada COMPILER...System: AST Premium 486 under UNIX System V, Release 4.0 Customer Agreement Number: 92-06-23- VRX See section 3.1 for any additional information about

  7. The Bronson Settlement Review: Year Four, 1987-88.

    ERIC Educational Resources Information Center

    Evans, Robert W.; Nieman, Ronald W.

    School year 1987-88 marked the mid-point of the seven-year desegregation settlement for the Cincinnati (Ohio) Public Schools. This report presents data from a review of progress that was provided for in the Bronson Settlement Agreement, answers plaintiff questions, and addresses district concerns. The following subjects are discussed: (1) progress…

  8. Analysis of Acoustic Emission Parameters from Corrosion of AST Bottom Plate in Field Testing

    NASA Astrophysics Data System (ADS)

    Jomdecha, C.; Jirarungsatian, C.; Suwansin, W.

    Field testing of aboveground storage tank (AST) to monitor corrosion of the bottom plate is presented in this chapter. AE testing data of the ten AST with different sizes, materials, and products were employed to monitor the bottom plate condition. AE sensors of 30 and 150 kHz were used to monitor the corrosion activity of up to 24 channels including guard sensors. Acoustic emission (AE) parameters were analyzed to explore the AE parameter patterns of occurring corrosion compared to the laboratory results. Amplitude, count, duration, and energy were main parameters of analysis. Pattern recognition technique with statistical was implemented to eliminate the electrical and environmental noises. The results showed the specific AE patterns of corrosion activities related to the empirical results. In addition, plane algorithm was utilized to locate the significant AE events from corrosion. Both results of parameter patterns and AE event locations can be used to interpret and locate the corrosion activities. Finally, basic statistical grading technique was used to evaluate the bottom plate condition of the AST.

  9. Non-amidated and amidated members of the C-type allatostatin (AST-C) family are differentially distributed in the stomatogastric nervous system of the American lobster, Homarus americanus.

    PubMed

    Christie, Andrew E; Miller, Alexandra; Fernandez, Rebecca; Dickinson, Evyn S; Jordan, Audrey; Kohn, Jessica; Youn, Mina C; Dickinson, Patsy S

    2018-01-13

    The crustacean stomatogastric nervous system (STNS) is a well-known model for investigating neuropeptidergic control of rhythmic behavior. Among the peptides known to modulate the STNS are the C-type allatostatins (AST-Cs). In the lobster, Homarus americanus, three AST-Cs are known. Two of these, pQIRYHQCYFNPISCF (AST-C I) and GNGDGRLYWRCYFNAVSCF (AST-C III), have non-amidated C-termini, while the third, SYWKQCAFNAVSCFamide (AST-C II), is C-terminally amidated. Here, antibodies were generated against one of the non-amidated peptides (AST-C I) and against the amidated isoform (AST-C II). Specificity tests show that the AST-C I antibody cross-reacts with both AST-C I and AST-C III, but not AST-C II; the AST-C II antibody does not cross-react with either non-amidated peptide. Wholemount immunohistochemistry shows that both subclasses (non-amidated and amidated) of AST-C are distributed throughout the lobster STNS. Specifically, the antibody that cross-reacts with the two non-amidated peptides labels neuropil in the CoGs and the stomatogastric ganglion (STG), axons in the superior esophageal (son) and stomatogastric (stn) nerves, and ~ 14 somata in each commissural ganglion (CoG). The AST-C II-specific antibody labels neuropil in the CoGs, STG and at the junction of the sons and stn, axons in the sons and stn, ~ 42 somata in each CoG, and two somata in the STG. Double immunolabeling shows that, except for one soma in each CoG, the non-amidated and amidated peptides are present in distinct sets of neuronal profiles. The differential distributions of the two AST-C subclasses suggest that the two peptide groups are likely to serve different modulatory roles in the lobster STNS.

  10. ASTE Surveys of Galactic Star-Forming Regions

    NASA Astrophysics Data System (ADS)

    Kohno, Kotaro

    2008-05-01

    We report some recent highlights on the observational studies of Galactic star formation based on surveys using the Atacama Submillimeter Telescope Experiment (ASTE), a new 10 m telescope in the Atacama desert in northern Chile (Kohno et al., 2008, ApSS, 313, 279). The highlights will include (1) a large scale CO(3-2) imaging survey of the Galactic Center, unveiling the presence of numerous compact high velocity clouds with high CO(3-2)/CO(1-0) ratios as a "fossil” of the recent burst of star formation in the Galactic Center region (Oka et al., 2007, PASJ, 59, 15; Nagai et al., 2007, PASJ, 59, 25; Tanaka et al., 2007, PASJ, 59, 323), (2) a large scale CO(3-2) imaging survey of the Sgr arm and inter-am regions, revealing the distinct difference on the morphology and physical property of molecular gas between the arm and inter-arm regions for the first time (Sawada, Koda, et al., in prep.), and (3) a wide area 1.1 mm imaging survey of Southern low mass star-forming regions such as Chamaeleon and Lupus molecular clouds using the bolometer camera AzTEC (Wilson et al., 2008, MNRAS, in press) mounted on ASTE, yielding detections of starless cores with a very low mass detection limist down to 0.1 solar masses (Hiramatsu, Tsukagoshi, Kawabe et al., in prep.). Related topics on the massive star-forming regions in very nearby galaxies such as LMC (Minamidani et al., 2008, ApJS, in press) and M 33 (Tosaki et al., 2007, ApJ, 664, L27; Onodera et al., in prep.; Komugi et al., in prep.) will also be reviewed.

  11. Oral activated charcoal adsorbent (AST-120) ameliorates extent and instability of atherosclerosis accelerated by kidney disease in apolipoprotein E-deficient mice

    PubMed Central

    Yamamoto, Suguru; Zuo, Yiqin; Ma, Ji; Yancey, Patricia G.; Hunley, Tracy E.; Motojima, Masaru; Fogo, Agnes B.; Linton, MacRae F.; Fazio, Sergio; Ichikawa, Iekuni

    2011-01-01

    Background. Accelerated atherosclerosis and increased cardiovascular events are not only more common in chronic kidney disease (CKD) but are more resistant to therapeutic interventions effective in the general population. The oral charcoal adsorbent, AST-120, currently used to delay start of dialysis, reduces circulating and tissue uremic toxins, which may contribute to vasculopathy, including atherosclerosis. We, therefore, investigated whether AST-120 affects CKD-induced atherosclerosis. Methods. Apolipoprotein E-deficient mice, a model of atherosclerosis, underwent uninephrectomy, subtotal nephrectomy or sham operation at 8 weeks of age and were treated with AST-120 after renal ablation. Atherosclerosis and its characteristics were assessed at 25 weeks of age. Results. Uninephrectomy and subtotal nephrectomised mice had significantly increased acceleration of atherosclerosis. AST-120 treatment dramatically reduced the atherosclerotic burden in mice with kidney damage, while there was no beneficial effect in sham-operated mice. The benefit was independent of blood pressure, serum total cholesterol or creatinine clearance. AST-120 significantly decreased necrotic areas and lessened aortic deposition of the uremic toxin indoxyl sulfate without affecting lesional macrophage or collagen content. Furthermore, AST-120 lessened aortic expression of monocyte chemoattractant protein-1, tumor necrosis factor-α and interleukin-1β messenger RNA. Conclusions. AST-120 lessens the extent of atherosclerosis induced by kidney injury and alters lesion characteristics in apolipoprotein E-deficient mice, resulting in plaques with a more stable phenotype with less necrosis and reduced inflammation. PMID:21245127

  12. 21 CFR 862.1100 - Aspartate amino transferase (AST/SGOT) test system.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Aspartate amino transferase (AST/SGOT) test system. 862.1100 Section 862.1100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES Clinical Chemistry...

  13. 21 CFR 862.1100 - Aspartate amino transferase (AST/SGOT) test system.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Aspartate amino transferase (AST/SGOT) test system. 862.1100 Section 862.1100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES Clinical Chemistry...

  14. 21 CFR 862.1100 - Aspartate amino transferase (AST/SGOT) test system.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Aspartate amino transferase (AST/SGOT) test system. 862.1100 Section 862.1100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES Clinical Chemistry...

  15. 21 CFR 862.1100 - Aspartate amino transferase (AST/SGOT) test system.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Aspartate amino transferase (AST/SGOT) test system. 862.1100 Section 862.1100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES Clinical Chemistry...

  16. 21 CFR 862.1100 - Aspartate amino transferase (AST/SGOT) test system.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Aspartate amino transferase (AST/SGOT) test system. 862.1100 Section 862.1100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES Clinical Chemistry...

  17. An AST-ELM Method for Eliminating the Influence of Charging Phenomenon on ECT.

    PubMed

    Wang, Xiaoxin; Hu, Hongli; Jia, Huiqin; Tang, Kaihao

    2017-12-09

    Electrical capacitance tomography (ECT) is a promising imaging technology of permittivity distributions in multiphase flow. To reduce the effect of charging phenomenon on ECT measurement, an improved extreme learning machine method combined with adaptive soft-thresholding (AST-ELM) is presented and studied for image reconstruction. This method can provide a nonlinear mapping model between the capacitance values and medium distributions by using machine learning but not an electromagnetic-sensitive mechanism. Both simulation and experimental tests are carried out to validate the performance of the presented method, and reconstructed images are evaluated by relative error and correlation coefficient. The results have illustrated that the image reconstruction accuracy by the proposed AST-ELM method has greatly improved than that by the conventional methods under the condition with charging object.

  18. Enzyme activity and AGE formation in a model of AST glycoxidation by D-fructose in vitro.

    PubMed

    Bousova, Iva; Vukasović, Danka; Juretić, Dubravka; Palicka, Vladimir; Drsata, Jaroslav

    2005-03-01

    Non-enzymatic glycation as the chain reaction between reducing sugars and free amino groups of proteins has been shown to correlate with physiological ageing and severity of diabetes. The process involves oxidative steps (glycoxidation). In this paper, the effect of D-fructose as a reactive sugar on aspartate aminotransferase (AST) as a model protein was monitored by measurements of the enzyme activity and formation of fluorescent advanced glycation end products (AGEs). Change in the AST activity was considered as a measure of the overall protein damage caused by glycation, and total AGEs and pentosidine represent, at least partly, the formation of glycoxidation products. Catalytic activity of AST in an incubation mixture containing D-fructose (50 mmol L(-1)), decreased compared to control values to 42% (p < 0.05) and to 11% (p < 0.05) on the 5th and on 21st day of incubation, respectively. In the presence of fructose, total fluorescent AGEs concentration was significantly higher since 5th day of incubation (110%, p < 0.05) and the fluorescent pentosidine concentration from 15th day of incubation (117%, p < 0.05) compared to control values, respectively. Catalytic activity of AST clearly and quantitatively demonstrated functional changes in the enzyme molecule caused by structural modifications initiated by fructose, while the evaluation of AGE formation and especially that of pentosidine by fluorescence measurement was less reliable.

  19. What is the acceptable hemolysis index for the measurements of plasma potassium, LDH and AST?

    PubMed

    Rousseau, Nathalie; Pige, Raphaëlle; Cohen, Richard; Pecquet, Matthieu

    2016-06-01

    Hemolysis is a cause of variability in test results for plasma potassium, LDH and AST and is a non-negligible part of measurement uncertainty. However, allowable levels of hemolysis provided by reagent suppliers take neither analytical variability (trueness and precision) nor the measurand into account. Using a calibration range of hemolysis, we measured the plasma concentrations of potassium, LDH and AST, and hemolysis indices with a Cobas C501 analyzer (Roche Diagnostics(®), Meylan, France). Based on the allowable total error (according to Ricós et al.) and the expanded measurement uncertainty equation we calculated the maximum allowable bias for two concentrations of each measurand. Finally, we determined the allowable hemolysis indices for all three measurands. We observed a linear relationship between the observed increases of concentration and hemolysis indices. The LDH measurement was the most sensitive to hemolysis, followed by AST and potassium measurements. The determination of the allowable hemolysis index depends on the targeted measurand, its concentration and the chosen level of requirement of allowable total error.

  20. An AST-ELM Method for Eliminating the Influence of Charging Phenomenon on ECT

    PubMed Central

    Wang, Xiaoxin; Hu, Hongli; Jia, Huiqin; Tang, Kaihao

    2017-01-01

    Electrical capacitance tomography (ECT) is a promising imaging technology of permittivity distributions in multiphase flow. To reduce the effect of charging phenomenon on ECT measurement, an improved extreme learning machine method combined with adaptive soft-thresholding (AST-ELM) is presented and studied for image reconstruction. This method can provide a nonlinear mapping model between the capacitance values and medium distributions by using machine learning but not an electromagnetic-sensitive mechanism. Both simulation and experimental tests are carried out to validate the performance of the presented method, and reconstructed images are evaluated by relative error and correlation coefficient. The results have illustrated that the image reconstruction accuracy by the proposed AST-ELM method has greatly improved than that by the conventional methods under the condition with charging object. PMID:29232850

  1. Astrobiology Road Mapping (AstRoMap) - A project within FP7 of the European Commission: First results

    NASA Astrophysics Data System (ADS)

    Gomez-Gomez, Felipe; Capria, Maria Teresa; Palomba, Ernesto; Walter, Nicolas; Rettberg, Petra; Muller, Christian; Horneck, Gerda

    AstRoMap (Astrobiology and Planetary Exploration Road Mapping) is a funded project formulated in the 5th Call of the European Commission FP7 framework. The main objectives of the AstRoMap are: 1. Identify the main astrobiology issues to be addressed by Europe in the next decades in relation with space exploration 2. Identify potential mission concepts that would allow addressing these issues 3. Identify the technology developments required to enable these missions 4. Provide a prioritized roadmap integrating science and technology activities as well as ground-based approach 5. Map scientific knowledge related to astrobiology in Europe To reach those objectives, AstRoMap is executed within the following steps: 1. Community consultation. In order to map the European astrobiology landscape and to provide a collaborative networking platform for this community, the AstRoMap project hosts a database of scientists (European and beyond) interested in astrobiology and planetary exploration (see: http://www.astromap.eu/database.html). It reflects the demography and the research and teaching activities of the astrobiology community, as well as their professional profiles and involvement in astrobiology projects. Considering future aspects of astrobiology in Europe, the need for more astrobiology-dedicated funding programmes at the EU level, especially for cross-disciplinary groups, was stressed. This might eventually lead to the creation of a European laboratory of Astrobiology, or even of a European Astrobiology Institute. 2. Workshops organisation. On the basis of the feedbacks from the community consultation, the potential participants and interesting topics are being identified to take part in the following workshops: 1-. Origin of organic compounds, steps to life; 2. Physico-chemical boundary conditions for habitability 3. Biosignatures as facilitating life detection 4. Origin of the Solar system 3. Astrobiology road-mapping. Based on the results and major conclusions

  2. Radio Identification of Millimeter-Bright Galaxies Detected in the AzTEC/ASTE Blank Field Survey

    NASA Astrophysics Data System (ADS)

    Hatsukade, Bunyo; Kohno, Kotaro; White, Glenn; Matsuura, Shuji; Hanami, Hitoshi; Shirahata, Mai; Nakanishi, Kouichiro; Hughes, David; Tamura, Yoichi; Iono, Daisuke; Wilson, Grant; Yun, Min

    2008-10-01

    We propose a deep 1.4-GHz imaging of millimeter-bright sources in the AzTEC/ASTE 1.1-mm blank field survey of AKARI Deep Field-South. The AzTEC/ASTE uncovered 37 sources, which are possibly at z > 2. We have obtained multi-wavelength data in this field, but the large beam size of AzTEC/ASTE (30 arcsec) prevents us from identifying counterparts. The aim of this proposal is to identify radio counterparts with higher-angular resolution. This enables us (i) To identifying optical/IR counterparts. It enables optical spectroscopy to determine precise redshifts, allowing us to derive SFRs, luminosity functions, clustering properties, mass of dark matter halos, etc. (ii) To constrain luminosity evolutions of SMGs by comparing of 1.4-GHz number counts (and luminosity functions) with luminosity evolution models. (iii) To estimate photometric redshifts from 1.4-GHz and 1.1-mm data using the radio-FIR flux correlation. In case of non-detection, we can put deep lower limits (3 sigma limit of z > 3). These information lead to the study of evolutionary history of SMGs, their relationship with other galaxy populations, contribution to the cosmic star formation history and the infrared background.

  3. AST: Activity-Security-Trust driven modeling of time varying networks.

    PubMed

    Wang, Jian; Xu, Jiake; Liu, Yanheng; Deng, Weiwen

    2016-02-18

    Network modeling is a flexible mathematical structure that enables to identify statistical regularities and structural principles hidden in complex systems. The majority of recent driving forces in modeling complex networks are originated from activity, in which an activity potential of a time invariant function is introduced to identify agents' interactions and to construct an activity-driven model. However, the new-emerging network evolutions are already deeply coupled with not only the explicit factors (e.g. activity) but also the implicit considerations (e.g. security and trust), so more intrinsic driving forces behind should be integrated into the modeling of time varying networks. The agents undoubtedly seek to build a time-dependent trade-off among activity, security, and trust in generating a new connection to another. Thus, we reasonably propose the Activity-Security-Trust (AST) driven model through synthetically considering the explicit and implicit driving forces (e.g. activity, security, and trust) underlying the decision process. AST-driven model facilitates to more accurately capture highly dynamical network behaviors and figure out the complex evolution process, allowing a profound understanding of the effects of security and trust in driving network evolution, and improving the biases induced by only involving activity representations in analyzing the dynamical processes.

  4. AST: Activity-Security-Trust driven modeling of time varying networks

    PubMed Central

    Wang, Jian; Xu, Jiake; Liu, Yanheng; Deng, Weiwen

    2016-01-01

    Network modeling is a flexible mathematical structure that enables to identify statistical regularities and structural principles hidden in complex systems. The majority of recent driving forces in modeling complex networks are originated from activity, in which an activity potential of a time invariant function is introduced to identify agents’ interactions and to construct an activity-driven model. However, the new-emerging network evolutions are already deeply coupled with not only the explicit factors (e.g. activity) but also the implicit considerations (e.g. security and trust), so more intrinsic driving forces behind should be integrated into the modeling of time varying networks. The agents undoubtedly seek to build a time-dependent trade-off among activity, security, and trust in generating a new connection to another. Thus, we reasonably propose the Activity-Security-Trust (AST) driven model through synthetically considering the explicit and implicit driving forces (e.g. activity, security, and trust) underlying the decision process. AST-driven model facilitates to more accurately capture highly dynamical network behaviors and figure out the complex evolution process, allowing a profound understanding of the effects of security and trust in driving network evolution, and improving the biases induced by only involving activity representations in analyzing the dynamical processes. PMID:26888717

  5. Review of Airport Ground Traffic Models Including an Evaluation of the ASTS Computer Program

    DOT National Transportation Integrated Search

    1972-12-01

    The report covers an evaluation of Airport Ground Traffic models for the purpose of simulating an Autonomous Local Intersection Controller. All known models were reviewed and a detailed study was performed on the two in-house models the ASTS and ROSS...

  6. VizieR Online Data Catalog: AzTEC/ASTE source catalogue (Aretxaga+, 2011)

    NASA Astrophysics Data System (ADS)

    Aretxaga, I.; Wilson, G. W.; Aguilar, E.; Alberts, S.; Scott, K. S.; Scoville, N.; Yun, M. S.; Austermann, J.; Downes, T. P.; Ezawa, H.; Hatsukade, B.; Hughes, D. H.; Kawabe, R.; Kohno, K.; Oshima, T.; Perera, T. A.; Tamura, Y.; Zeballos, M.

    2013-02-01

    We imaged a 2800 arcmin2 field centred at right ascension RA(J2000.0)=10:00:30.00 and declination DE(J2000.0)=2:14.00 with AzTEC mounted on the 10-m ASTE, located at 4800m in the Atacama Desert of Chile. The survey was carried out from 2008 October 20 to November 30. (1 data file).

  7. Agreement between Oakland University and the Oakland University Chapter, American Association of University Professors, 1985-88.

    ERIC Educational Resources Information Center

    American Association of Univ. Professors, Washington, DC.

    The collective bargaining agreement between Oakland University and the University's chapter (370 members) of the American Association of University Professors (AAUP) covering the period 1985-1988 is presented. Items covered in the agreement include: definitions and recognition of AAUP, academic titles, AAUP rights, university management,…

  8. Characteristics of the advanced supersonic technology AST-105-1 configured for transpacific range with Pratt and Whitney aircraft variable stream control engines

    NASA Technical Reports Server (NTRS)

    Baber, H. T., Jr.

    1979-01-01

    Credence to systems weights and assurance that the noise study AST concept can be balanced were studied. Current titanium structural technology is assumed. A duct-burning turbofan variable stream control engine (VSCE), with noise reduction potential through use of a coannular nozzle was used. With 273 passengers, range of the AST-105-1 for a cruise Mach number of 2.62 is essentially transpacific. Lift-to-drag ratio is slightly higher than for previous AST configurations. It is trimmable over a center-of-gravity range of 4.7m (15.5 ft). Inherent high positive effective dihedral, typical of arrow-wing configurations in high-lift approach, would limit AST-105-1 to operating in crosswinds of 11.6 m/sec (22.4 kt), or less, with 75 percent of available lateral control. Normal power takeoff with cutback results in noise in excess of Federal Aviation Regulation Part 36 but less than for conventional procedure takeoff. Results of advanced (noncertificated) programmed throttle takeoff and approach procedures, not yet optimized, indicate that such can be an important additional method noise reduction.

  9. Astakine LvAST binds to the β subunit of F1-ATP synthase and likely plays a role in white shrimp Litopeneaus vannamei defense against white spot syndrome virus.

    PubMed

    Liang, Gao-Feng; Liang, Yan; Xue, Qinggang; Lu, Jin-Feng; Cheng, Jun-Jun; Huang, Jie

    2015-03-01

    Cytokines play a critical role in innate and adaptive immunity. Astakines represent a group of invertebrate cytokines that are related to vertebrate prokineticin and function in promoting hematopoiesis in crustaceans. We have identified an astakine from the white shrimp Litopeneaus vannamei and named it LvAST in a previous research. In the present research, we investigated the interactions among LvAST, the envelope protein VP37 of white spot syndrome virus (i.e., WSSV), and the β subunit of F1-ATP synthase (ATPsyn-β) of the white shrimp (i.e., BP53) using binding assays and co-precipitations. We also examined the effects of LvAST on shrimp susceptibility to WSSV. We found that LvAST and VP37 competitively bound to BP53, but did not bind to each other. Shrimps that had been injected with recombinant LvAST exhibited significantly lower mortality and longer survival time in experimental infections by WSSV. In contrast, shrimps whose LvAST gene expression had been inhibited by RNA interference showed significantly higher WSSV infection intensity and shorter survival time following viral challenges. These results suggested that LvAST and WSSV both likely use ATPsyn-β as a receptor and LvAST plays a role in shrimp defense against WSSV infection. This represented the first research showing the involvement of astakines in host antiviral immunity. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Photonuclear production of yttrium-88 - A high energy gamma emitter for hydrocarbon extraction applications.

    PubMed

    Dale, Daniel S; Starovoitova, Valeriia N; Forest, Tony A; Oliphant, Emily

    2018-05-05

    The use of fracing has risen over the past decade and revolutionized energy production in the US. However, there is still an impetus for further optimization of the extraction of oil and natural gas from vast shale reservoirs. In this work, we discuss photonuclear production of yttrium-88 as a promising radiotracer for fracing operations. Single neutron knock-out from natural monoisotopic yttrium-89 is an inexpensive process resulting in high activity of 88 Y with minimal impurities. MCNPX simulations were performed to estimate the 88 Y yield. Irradiations of natural yttrium using a 32 MeV electron linac equipped with a tungsten bremsstrahlung converter were done to benchmark the simulations. Activities of 88 Y, 87g Y, and 87m Y were measured and found to be in good agreement with the predictions. Copyright © 2018 Elsevier Ltd. All rights reserved.

  11. AST: An Automated Sequence-Sampling Method for Improving the Taxonomic Diversity of Gene Phylogenetic Trees

    PubMed Central

    Zhou, Chan; Mao, Fenglou; Yin, Yanbin; Huang, Jinling; Gogarten, Johann Peter; Xu, Ying

    2014-01-01

    A challenge in phylogenetic inference of gene trees is how to properly sample a large pool of homologous sequences to derive a good representative subset of sequences. Such a need arises in various applications, e.g. when (1) accuracy-oriented phylogenetic reconstruction methods may not be able to deal with a large pool of sequences due to their high demand in computing resources; (2) applications analyzing a collection of gene trees may prefer to use trees with fewer operational taxonomic units (OTUs), for instance for the detection of horizontal gene transfer events by identifying phylogenetic conflicts; and (3) the pool of available sequences is biased towards extensively studied species. In the past, the creation of subsamples often relied on manual selection. Here we present an Automated sequence-Sampling method for improving the Taxonomic diversity of gene phylogenetic trees, AST, to obtain representative sequences that maximize the taxonomic diversity of the sampled sequences. To demonstrate the effectiveness of AST, we have tested it to solve four problems, namely, inference of the evolutionary histories of the small ribosomal subunit protein S5 of E. coli, 16 S ribosomal RNAs and glycosyl-transferase gene family 8, and a study of ancient horizontal gene transfers from bacteria to plants. Our results show that the resolution of our computational results is almost as good as that of manual inference by domain experts, hence making the tool generally useful to phylogenetic studies by non-phylogeny specialists. The program is available at http://csbl.bmb.uga.edu/~zhouchan/AST.php. PMID:24892935

  12. AST: an automated sequence-sampling method for improving the taxonomic diversity of gene phylogenetic trees.

    PubMed

    Zhou, Chan; Mao, Fenglou; Yin, Yanbin; Huang, Jinling; Gogarten, Johann Peter; Xu, Ying

    2014-01-01

    A challenge in phylogenetic inference of gene trees is how to properly sample a large pool of homologous sequences to derive a good representative subset of sequences. Such a need arises in various applications, e.g. when (1) accuracy-oriented phylogenetic reconstruction methods may not be able to deal with a large pool of sequences due to their high demand in computing resources; (2) applications analyzing a collection of gene trees may prefer to use trees with fewer operational taxonomic units (OTUs), for instance for the detection of horizontal gene transfer events by identifying phylogenetic conflicts; and (3) the pool of available sequences is biased towards extensively studied species. In the past, the creation of subsamples often relied on manual selection. Here we present an Automated sequence-Sampling method for improving the Taxonomic diversity of gene phylogenetic trees, AST, to obtain representative sequences that maximize the taxonomic diversity of the sampled sequences. To demonstrate the effectiveness of AST, we have tested it to solve four problems, namely, inference of the evolutionary histories of the small ribosomal subunit protein S5 of E. coli, 16 S ribosomal RNAs and glycosyl-transferase gene family 8, and a study of ancient horizontal gene transfers from bacteria to plants. Our results show that the resolution of our computational results is almost as good as that of manual inference by domain experts, hence making the tool generally useful to phylogenetic studies by non-phylogeny specialists. The program is available at http://csbl.bmb.uga.edu/~zhouchan/AST.php.

  13. Operation of AST3 telescope and site testing at Dome A, Antarctica

    NASA Astrophysics Data System (ADS)

    Shang, Zhaohui; Hu, Yi; Ma, Bin; Hu, Keliang; Ashley, Michael C. B.; Wang, Lifan; Yuan, Xiangyan

    2016-07-01

    We have successfully operated the AST3 telescope remotely as well as robotically for time-domain sky survey in 2015 and 2016. We have set up a real-time system to support the operation of the unattended telescope, monitoring the status of all instruments as well as the weather conditions. The weather tower also provides valuable information of the site at the highest plateau in Antarctica, demonstrating the extremely stable atmosphere above the ground and implying excellent seeing at Dome A.

  14. Laboratory blood analysis in Strigiformes-Part II: plasma biochemistry reference intervals and agreement between the Abaxis Vetscan V2 and the Roche Cobas c501.

    PubMed

    Ammersbach, Mélanie; Beaufrère, Hugues; Gionet Rollick, Annick; Tully, Thomas

    2015-03-01

    Limited plasma biochemical information is available in Strigiformes. Only one study investigated the agreement between a point-of-care with a reference laboratory analyzer for biochemistry variables in birds. The objective was to report reference intervals (RI) for plasma biochemistry variables in Strigiformes, and to assess agreement between the Abaxis Vetscan V2 and Roche Cobas c501. A prospective study was designed to assess plasma biochemistry RI for concentration of calcium, phosphorus, total protein, albumin, globulin, glucose, bilirubin, uric acid, bile acids, sodium, potassium, and chloride, and activities of AST, GGT, CK, amylase, lipase, LDH, and GLDH. In addition, the agreement between the Vetscan and the Cobas in owl species was assessed. A total of 190 individuals were sampled belonging to 12 Strigiformes species including Barn Owls, Barred Owls, Great Horned Owls, Eurasian Eagle Owls, Spectacled Owls, Eastern Screech Owls, Long-Eared Owls, Short-Eared Owls, Great Gray Owls, Snowy Owls, Northern Saw-Whet Owls, and Northern Hawk-Owls. Order-, species-, and method-specific RI were determined on both analyzers. Although Vetscan data were not equivalent to the Cobas, 4 analytes (glucose, AST, CK, and total protein, with correction for bias) were within acceptable agreement, 3 analytes (uric acid, calcium, and phosphorus) were within close agreement, and the remaining analytes were in strong disagreement. Species-specific differences were observed notably for the concentration of glucose in Barn Owls and electrolytes in Northern Saw-Whet Owls. Overall, this study suggests that the Vetscan has acceptable clinical performance in Strigiformes for some analytes and highlights discrepancies for several analytes. © 2015 American Society for Veterinary Clinical Pathology.

  15. The effects of AST-120 on chronic kidney disease progression in the United States of America: a post hoc subgroup analysis of randomized controlled trials.

    PubMed

    Schulman, Gerald; Berl, Tomas; Beck, Gerald J; Remuzzi, Giuseppe; Ritz, Eberhard; Shimizu, Miho; Shobu, Yuko; Kikuchi, Mami

    2016-09-30

    The orally administered spherical carbon adsorbent AST-120 is used on-label in Asian countries to slow renal disease progression in patients with progressive chronic kidney disease (CKD). Recently, two multinational, randomized, double-blind, placebo-controlled, phase 3 trials (Evaluating Prevention of Progression in Chronic Kidney Disease [EPPIC] trials) examined AST-120's efficacy in slowing CKD progression. This study assessed the efficacy of AST-120 in the subgroup of patients from the United States of America (USA) in the EPPIC trials. In the EPPIC trials, 2035 patients with moderate to severe CKD were studied, of which 583 were from the USA. The patients were randomly assigned to two groups of equal size that were treated with AST-120 or placebo (9 g/day). The primary end point was a composite of dialysis initiation, kidney transplantation, or serum creatinine doubling. The Kaplan-Meier curve for the time to achieve the primary end point in the placebo-treated patients from the USA was similar to that projected before the study. The per protocol subgroup analysis of the population from the USA which included patients with compliance rates of ≥67 % revealed a significant difference between the treatment groups in the time to achieve the primary end point (Hazard Ratio, 0.74; 95 % Confidence Interval, 0.56-0.97). This post hoc subgroup analysis of EPPIC study data suggests that treatment with AST-120 might delay the time to primary end point in CKD patients from the USA. A further randomized controlled trial in progressive CKD patients in the USA is necessary to confirm the beneficial effect of adding AST-120 to standard therapy regimens. ClinicalTrials.gov NCT00500682 ; NCT00501046 .

  16. Identification and Antifungal Susceptibility Testing of Candida Species: A Comparison of Vitek-2 System with Conventional and Molecular Methods.

    PubMed

    Kaur, Ravinder; Dhakad, Megh Singh; Goyal, Ritu; Haque, Absarul; Mukhopadhyay, Gauranga

    2016-01-01

    Candida infection is a major cause of morbidity and mortality in immunocompromised patients; an accurate and early identification is a prerequisite need to be taken as an effective measure for the management of patients. The purpose of this study was to compare the conventional identification of Candida species with identification by Vitek-2 system and the antifungal susceptibility testing (AST) by broth microdilution method with Vitek-2 AST system. A total of 172 Candida isolates were subjected for identification by the conventional methods, Vitek-2 system, restriction fragment length polymorphism, and random amplified polymorphic DNA analysis. AST was carried out as per the Clinical and Laboratory Standards Institute M27-A3 document and by Vitek-2 system. Candida albicans (82.51%) was the most common Candida species followed by Candida tropicalis (6.29%), Candida krusei (4.89%), Candida parapsilosis (3.49%), and Candida glabrata (2.79%). With Vitek-2 system, of the 172 isolates, 155 Candida isolates were correctly identified, 13 were misidentified, and four were with low discrimination. Whereas with conventional methods, 171 Candida isolates were correctly identified and only a single isolate of C. albicans was misidentified as C. tropicalis . The average measurement of agreement between the Vitek-2 system and conventional methods was >94%. Most of the isolates were susceptible to fluconazole (88.95%) and amphotericin B (97.67%). The measurement of agreement between the methods of AST was >94% for fluconazole and >99% for amphotericin B, which was statistically significant ( P < 0.01). The study confirmed the importance and reliability of conventional and molecular methods, and the acceptable agreements suggest Vitek-2 system an alternative method for speciation and sensitivity testing of Candida species infections.

  17. Variable Stars Observed in the Galactic Disk by AST3-1 from Dome A, Antarctica

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Lingzhi; Ma, Bin; Hu, Yi

    AST3-1 is the second-generation wide-field optical photometric telescope dedicated to time-domain astronomy at Dome A, Antarctica. Here, we present the results of an i -band images survey from AST3-1 toward one Galactic disk field. Based on time-series photometry of 92,583 stars, 560 variable stars were detected with i magnitude ≤16.5 mag during eight days of observations; 339 of these are previously unknown variables. We tentatively classify the 560 variables as 285 eclipsing binaries (EW, EB, and EA), 27 pulsating variable stars ( δ Scuti, γ Doradus, δ Cephei variable, and RR Lyrae stars), and 248 other types of variables (unclassifiedmore » periodic, multiperiodic, and aperiodic variable stars). Of the eclipsing binaries, 34 show O’Connell effects. One of the aperiodic variables shows a plateau light curve and another variable shows a secondary maximum after peak brightness. We also detected a complex binary system with an RS CVn-like light-curve morphology; this object is being followed-up spectroscopically using the Gemini South telescope.« less

  18. Circulating AST, H-FABP, and NGAL are early and accurate biomarkers of graft injury and dysfunction in a preclinical model of kidney transplantation.

    PubMed

    Jochmans, Ina; Lerut, Evelyne; van Pelt, Jos; Monbaliu, Diethard; Pirenne, Jacques

    2011-11-01

    To investigate circulating biomarkers of initial graft injury in a porcine kidney autotransplant model. Injury endured by kidney grafts early posttransplant determines their outcome. However, creatinine (clearance) is a poor surrogate of tissue injury and urinary biomarkers are limited by graft anuria or persistent native kidney diuresis. No validated circulating biomarkers quantifying initial graft injury exist. Minimally injured porcine kidney grafts (n = 6) were cold stored (18 hours) and autotransplanted. Moderately (n = 6) and severely injured grafts (n = 7) were exposed to 30 or 60 minutes warm ischemia before storage and autotransplantation. Four biomarkers [aspartate transaminase (AST), heart-type fatty acid-binding protein (H-FABP), neutrophil gelatinase-associated lipocalin (NGAL), and N-acetyl-β-glucosaminidase (NAG)] were measured posttransplant and compared with creatinine (clearance) and histology. Diuresis was delayed in moderately [2.5 days (2-3)] and severely [4 days (4-5)] versus minimally injured grafts (P < 0.001). Creatinine peaked later than AST, H-FABP, and NGAL [4 days (3-5) vs 3 hours (3-6), 6 hours (6-24), 2 days (1-3), respectively] and only differentiated minimally from severely injured grafts. Peak AST and H-FABP distinguished all injury grades. Neutrophil gelatinase-associated lipocalin discriminated initial graft injury 2 days posttransplant. Peak AST, H-FABP, and NGAL correlated with peak creatinine [Pearson coefficients: 0.70 (P = 0.001), 0.85 (P < 0.0001), 0.80 (P < 0.0001)]. N-acetyl-β-glucosaminidase was not different. Decreased clearance accounted for a small percentage of H-FABP and NGAL increase. Histology was not different among transplanted groups. Plasma AST, H-FABP, and NGAL reflect the severity of initial kidney graft injury and predict graft dysfunction earlier and more accurately than creatinine (clearance) and histology. They represent promising tools to improve patient care after kidney transplantation.

  19. GEOHAZARDS '88GEOHAZARDS '88

    NASA Astrophysics Data System (ADS)

    Hodges, Carroll Ann

    Durant's prophetic observation provided the perfect mantra for GEOHAZARDS '88, a symposium highlighting research on the causes, effects, and prediction of geologic and hydrologic hazards, held November 17-18, 1988, at the U.S. Geological Survey's Western Region Headquarters in Menlo Park, Calif. All three research divisions of the Survey—Geologic, Water Resources, and National Mapping—contributed to the program.USGS has long been engaged in research on hazardous environments resulting from geologic and hydrologic factors, and that research has been especially vigorous at its Western Region offices. It was appropriate therefore that this forum convene at the locus of tectonic ferment on the edge of the North American plate, adjacent to the San Andreas fault. An open house for the general public highlighting all aspects of USGS programs followed the symposium November 19. The purpose of GEOHAZARDS '88 was to provide an opportunity for USGS scientists and other investigators to talk with local, state, and federal officials who must react to the findings of Earth science research with judicious policy decisions. Making such decisions is neither easy nor enviable. Yet the citizenry demands and is entitled to enlightened policy regarding the hazardous geologic and hydrologic conditions with which we necessarily live, particularly on the west coast. California serves as de facto proving ground for building codes and land-use decisions because of the high frequency with which they are tested by natural events somewhere in the state.

  20. Lepton-flavor universality violation in R K and {R}_{D{_{(\\ast )}}} from warped space

    NASA Astrophysics Data System (ADS)

    Megías, Eugenio; Quirós, Mariano; Salas, Lindber

    2017-07-01

    Some anomalies in the processes b → sℓℓ ( ℓ = μ, e) and b\\to cℓ {\\overline{ν}}_{ℓ } ( ℓ = τ, μ, e), in particular in the observables R K and {R}_{D{_{(\\ast )}}} , have been found by the BaBar, LHCb and Belle collaborations, leading to a possible lepton flavor universality violation. If these anomalies were confirmed they would inevitably lead to physics beyond the Standard Model. In this paper we try to accommodate the present anomalies in an extra dimensional theory, solving the naturalness problem of the Standard Model by means of a warped metric with a strong conformality violation near the infra-red brane. The R K anomaly can be accommodated provided that the left-handed bottom quark and muon lepton have some degree of compositeness in the dual theory. The theory is consistent with all electroweak and flavor observables, and with all direct searches of Kaluza-Klein electroweak gauge bosons and gluons. The fermion spectrum, and fermion mixing angles, can be reproduced by mostly elementary right-handed bottom quarks, and tau and muon leptons. Moreover the {R}_{D{_{(\\ast )}}} anomaly requires a strong degree of compositeness for the left-handed tau leptons, which turns out to be in tension with experimental data on the {g}_{τ_L}^Z coupling, possibly unless some degree of fine-tuning is introduced in the fixing of the CKM matrix.

  1. Astrophysical properties of star clusters in the Magellanic Clouds homogeneously estimated by ASteCA

    NASA Astrophysics Data System (ADS)

    Perren, G. I.; Piatti, A. E.; Vázquez, R. A.

    2017-06-01

    Aims: We seek to produce a homogeneous catalog of astrophysical parameters of 239 resolved star clusters, located in the Small and Large Magellanic Clouds, observed in the Washington photometric system. Methods: The cluster sample was processed with the recently introduced Automated Stellar Cluster Analysis (ASteCA) package, which ensures both an automatized and a fully reproducible treatment, together with a statistically based analysis of their fundamental parameters and associated uncertainties. The fundamental parameters determined for each cluster with this tool, via a color-magnitude diagram (CMD) analysis, are metallicity, age, reddening, distance modulus, and total mass. Results: We generated a homogeneous catalog of structural and fundamental parameters for the studied cluster sample and performed a detailed internal error analysis along with a thorough comparison with values taken from 26 published articles. We studied the distribution of cluster fundamental parameters in both Clouds and obtained their age-metallicity relationships. Conclusions: The ASteCA package can be applied to an unsupervised determination of fundamental cluster parameters, which is a task of increasing relevance as more data becomes available through upcoming surveys. A table with the estimated fundamental parameters for the 239 clusters analyzed is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/602/A89

  2. 38 CFR 4.88 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false [Reserved] 4.88 Section 4.88 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS SCHEDULE FOR RATING DISABILITIES Disability Ratings Infectious Diseases, Immune Disorders and Nutritional Deficiencies § 4.88...

  3. 38 CFR 4.88 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false [Reserved] 4.88 Section 4.88 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS SCHEDULE FOR RATING DISABILITIES Disability Ratings Infectious Diseases, Immune Disorders and Nutritional Deficiencies § 4.88...

  4. 38 CFR 4.88 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false [Reserved] 4.88 Section 4.88 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS SCHEDULE FOR RATING DISABILITIES Disability Ratings Infectious Diseases, Immune Disorders and Nutritional Deficiencies § 4.88...

  5. 38 CFR 4.88 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false [Reserved] 4.88 Section 4.88 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS SCHEDULE FOR RATING DISABILITIES Disability Ratings Infectious Diseases, Immune Disorders and Nutritional Deficiencies § 4.88...

  6. 38 CFR 4.88 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false [Reserved] 4.88 Section 4.88 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS SCHEDULE FOR RATING DISABILITIES Disability Ratings Infectious Diseases, Immune Disorders and Nutritional Deficiencies § 4.88...

  7. 40 CFR 763.88 - Assessment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Assessment. 763.88 Section 763.88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos-Containing Materials in Schools § 763.88 Assessment. (a)(1) For each inspection and reinspection...

  8. 40 CFR 763.88 - Assessment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Assessment. 763.88 Section 763.88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos-Containing Materials in Schools § 763.88 Assessment. (a)(1) For each inspection and reinspection...

  9. 40 CFR 763.88 - Assessment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Assessment. 763.88 Section 763.88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos-Containing Materials in Schools § 763.88 Assessment. (a)(1) For each inspection and reinspection...

  10. 40 CFR 763.88 - Assessment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Assessment. 763.88 Section 763.88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos-Containing Materials in Schools § 763.88 Assessment. (a)(1) For each inspection and reinspection...

  11. 40 CFR 763.88 - Assessment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Assessment. 763.88 Section 763.88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos-Containing Materials in Schools § 763.88 Assessment. (a)(1) For each inspection and reinspection...

  12. 40 CFR 98.88 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Definitions. 98.88 Section 98.88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Cement Production § 98.88 Definitions. All terms used in this subpart have the same...

  13. 40 CFR 98.88 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Definitions. 98.88 Section 98.88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Cement Production § 98.88 Definitions. All terms used in this subpart have the same...

  14. 40 CFR 98.88 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Definitions. 98.88 Section 98.88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Cement Production § 98.88 Definitions. All terms used in this subpart have the same...

  15. 40 CFR 98.88 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Definitions. 98.88 Section 98.88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Cement Production § 98.88 Definitions. All terms used in this subpart have the same...

  16. 40 CFR 98.88 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 21 2011-07-01 2011-07-01 false Definitions. 98.88 Section 98.88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Cement Production § 98.88 Definitions. All terms used in this subpart have the same...

  17. 37 CFR 1.88 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false [Reserved] 1.88 Section 1.88 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES National Processing Provisions The Drawings § 1.88 [Reserved...

  18. Multi-hazard Assessment and Scenario Toolbox (MhAST): A Framework for Analyzing Compounding Effects of Multiple Hazards

    NASA Astrophysics Data System (ADS)

    Sadegh, M.; Moftakhari, H.; AghaKouchak, A.

    2017-12-01

    Many natural hazards are driven by multiple forcing variables, and concurrence/consecutive extreme events significantly increases risk of infrastructure/system failure. It is a common practice to use univariate analysis based upon a perceived ruling driver to estimate design quantiles and/or return periods of extreme events. A multivariate analysis, however, permits modeling simultaneous occurrence of multiple forcing variables. In this presentation, we introduce the Multi-hazard Assessment and Scenario Toolbox (MhAST) that comprehensively analyzes marginal and joint probability distributions of natural hazards. MhAST also offers a wide range of scenarios of return period and design levels and their likelihoods. Contribution of this study is four-fold: 1. comprehensive analysis of marginal and joint probability of multiple drivers through 17 continuous distributions and 26 copulas, 2. multiple scenario analysis of concurrent extremes based upon the most likely joint occurrence, one ruling variable, and weighted random sampling of joint occurrences with similar exceedance probabilities, 3. weighted average scenario analysis based on a expected event, and 4. uncertainty analysis of the most likely joint occurrence scenario using a Bayesian framework.

  19. 21 CFR 808.88 - Pennsylvania.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Pennsylvania. 808.88 Section 808.88 Food and Drugs... and Local Exemptions § 808.88 Pennsylvania. (a) The following Pennsylvania medical device requirements... the condition that, in enforcing this requirement, Pennsylvania apply the definition of “used hearing...

  20. 9 CFR 381.88 - Parasites.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Parasites. 381.88 Section 381.88 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... § 381.88 Parasites. Organs or other parts of carcasses which are found to be infested with parasites, or...

  1. Identification, functional characterization and expression pattern of myeloid differentiation factor 88 (MyD88) in Sepiella japonica.

    PubMed

    Huo, Liping; Bao, Miaomiao; Lv, Zhenming; Chi, Changfeng; Wang, Tianming; Liu, Huihui

    2018-05-01

    Myeloid differentiation factor 88 (MyD88) is an adaptor protein involved in the interleukin-1 receptor and Toll-like receptor-induced activation of nuclear factor-κB (NF-κB). In this study a novel isoform of MyD88 in Sepiella japonica (SjMyD88) was cloned and functionally characterized (GenBank accession no. AQY56781.1). The complete cDNA sequence of SjMyD88 was 1912 bp and contained a 1017 bp open reading frame encoding 338 amino acid residues, which was similar to its mollusk orthologues in the length. BLASTp analysis suggested the deduced amino acids sequence of SjMyD88 shared high identity to the known MyD88, for instance, 64% identity with Octopus bimaculoides. Sequence analysis revealed two conserved domains, the N-terminal DD and the C-terminal TIR domain appeared in SjMyD88, which was consistent with MyD88 proteins from other species. The fusion expression of SjMyD88 and green fluorescent protein (EGFP) in HEK293 cells was conducted and cytoplasm localization was detected. Meanwhile, the TIR-pmCherry fusion protein showed red fluorescence and mainly distributed in the cytoplasm. After cotransfection MyD88-EGFP and TIR-pmCherry red obviously overlapped and changed to yellowish green. The results suggested that there was the interaction between homologous TIR-pmcherry and MyD88-EGFP. Tissues expression profiles analysis showed that SjMyD88 ubiquitously expressed in all tested tissues with the highest expression in the gills and livers except reproductive related tissue, and it was significantly induced in livers under LPS stress. These data provide insight into the roles of SjMyD88 in the TLR signaling pathway of S. japonica in response to pathogenic bacteria. Copyright © 2018. Published by Elsevier Ltd.

  2. 34 CFR 668.88 - Hearing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false Hearing. 668.88 Section 668.88 Education Regulations of... Proceedings § 668.88 Hearing. (a) A hearing is an orderly presentation of arguments and evidence conducted by a hearing official. (b) If the hearing official, the designated department official who brought a...

  3. 34 CFR 668.88 - Hearing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Hearing. 668.88 Section 668.88 Education Regulations of... Proceedings § 668.88 Hearing. (a) A hearing is an orderly presentation of arguments and evidence conducted by a hearing official. (b) If the hearing official, the designated department official who brought a...

  4. Testing minimal flavor violation in leptoquark models of the {R_K}{^{(\\ast )}} anomaly

    NASA Astrophysics Data System (ADS)

    Aloni, Daniel; Dery, Avital; Frugiuele, Claudia; Nir, Yosef

    2017-11-01

    The {R_K}{^{(\\ast )}} anomaly can be explained by tree level exchange of leptoquarks. We study the consequences of subjecting these models to the principle of minimal flavor violation (MFV). We consider MFV in the linear regime, and take the charged lepton Yukawa matrix to be the only spurion that violates lepton flavor universality. We find that a combination of constraints from a variety of processes — b → sμμ, b → sττ , b → sνν, b\\overline{b}\\to τ τ and b → cτν — excludes MFV in these models.

  5. Towards a Continental Energy Market: From the Energy Crisis to the Free Trade Agreement, 1970-88.

    ERIC Educational Resources Information Center

    Bennett, Paul W.

    1989-01-01

    Discusses the impact the 1973 oil embargo and resulting energy crisis had on Canadian energy policies, which eventually led in 1987 to the enactment of the Free Trade Agreement between Canada and the United States. Includes excerpts of three documents which reveal much about the shift in Canadian policy toward a continental energy market. (LS)

  6. Conceptual study of an advanced supersonic technology transport (AST-107) for transpacific range using low-bypass-ratio turbofan engines

    NASA Technical Reports Server (NTRS)

    Morris, S. J., Jr.; Foss, W. E., Jr.; Neubauer, M. J., Jr.

    1980-01-01

    An advanced supersonic technology configuration concept designated the AST-107, using a low bypass ratio turbofan engine, is described and analyzed. The aircraft had provisions for 273 passengers arranged five abreast. The cruise Mach number was 2.62. The mission range for the AST-107 was 8.48 Mm (4576 n.mi.) and an average lift drag ratio of 9.15 during cruise was achieved. The available lateral control was not sufficient for the required 15.4 m/s (30 kt) crosswind landing condition, and a crosswind landing gear or a significant reduction in dihedral effect would be necessary to meet this requirement. The lowest computed noise levels, including a mechanical suppressor noise reduction of 3 EPNdB at the flyover and sideline monitoring stations, were 110.3 EPNdB (sideline noise), 113.1 EPNdB (centerline noise) and 110.5 EPNdB (approach noise).

  7. Intra- and interobserver agreement for fetal cerebral measurements in 3D-ultrasonography.

    PubMed

    Albers, Maria E W A; Buisman, Erato T I A; Kahn, René S; Franx, Arie; Onland-Moret, N Charlotte; de Heus, Roel

    2018-04-10

    The aim of this study is to evaluate intra- and interobserver agreement for measurement of intracranial, cerebellar, and thalamic volume with the Virtual Organ Computer-aided AnaLysis (VOCAL) technique in three-dimensional ultrasound images, in comparison to two-dimensional measurements of these brain structures. Three-dimensional ultrasound images of the brains of 80 fetuses at 20-24 weeks' gestational age were obtained from YOUth, a Dutch prospective cohort study. Two observers performed offline measurement of the occipitofrontal diameter, intracranial volume, transcerebellar diameter, cerebellar volume, and thalamic width, area, and volume, independently. VOCAL was used for calculation of the volumes. The two-way random, single measures intraclass correlation coefficient (ICC) was used for analysis of agreement and Bland-Altman plots were configured. Intra- and interobserver agreement was almost perfect for occipitofrontal diameter (intra ICC 0.88, 95% CI 0.82-0.92; inter ICC 0.91, 95% CI 0.85-0.94), intracranial volume (intra ICC 0.96, 95% CI 0.91-0.98; inter ICC 0.97, 95% CI 0.96-0.98) and transcerebellar diameter (intra ICC 0.91, 95% CI 0.86-0.94; inter ICC 0.86, 95% CI 0.78-0.910). For cerebellar volume, the intraobserver agreement was almost perfect (0.85, 95% CI 0.76-0.90), whereas the interobserver agreement was substantial (0.75, 95% CI 0.44-0.88). Agreement was only moderate for thalamic measurements. Bland-Altman plots for the volume measurements are normally distributed with acceptable mean differences and 95% limits of agreement. The intra- and interobserver agreement of the measurement of intracranial and cerebellar volume with VOCAL was almost perfect. These measurements are therefore reliable, and can be used to investigate fetal brain development. Thalamic measurements are not reliable enough. © 2018 Wiley Periodicals, Inc.

  8. Proposal Information | ast.noao.edu

    Science.gov Websites

    Logo NOAO is the national center for ground-based nighttime astronomy in the United States and is operated by the Association of Universities for Research in Astronomy (AURA). under cooperative agreement with the National Science Foundation. If you would like information about solar astronomy, visit the

  9. Differences in levels of albumin, ALT, AST, γ-GT and creatinine in frail, moderately healthy and healthy elderly individuals.

    PubMed

    Edvardsson, Maria; Sund-Levander, Märtha; Milberg, Anna; Wressle, Ewa; Marcusson, Jan; Grodzinsky, Ewa

    2018-02-23

    Reference intervals are widely used as decision tools, providing the physician with information about whether the analyte values indicate ongoing disease process. Reference intervals are generally based on individuals without diagnosed diseases or use of medication, which often excludes elderly. The aim of the study was to assess levels of albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine and γ-glutamyl transferase (γ-GT) in frail, moderately healthy and healthy elderly indivuduals. Blood samples were collected from individuals >80 years old, nursing home residents, in the Elderly in Linköping Screening Assessment and Nordic Reference Interval Project, a total of 569 individuals. They were divided into three cohorts: frail, moderately healthy and healthy, depending on cognitive and physical function. Albumin, ALT, AST, creatinine and γ-GT were analyzed using routine methods. Linear regression predicted factors for 34% of the variance in albumin were activities of daily living (ADL), gender, stroke and cancer. ADLs, gender and weight explained 15% of changes in ALT. For AST levels, ADLs, cancer and analgesics explained 5% of changes. Kidney disease, gender, Mini Mental State Examination (MMSE) and chronic obstructive pulmonary disease explained 25% of the variation in creatinine levels and MMSE explained three per cent of γ-GT variation. Because a group of people are at the same age, they should not be assessed the same way. To interpret results of laboratory tests in elderly is a complex task, where reference intervals are one part, but far from the only one, to take into consideration.

  10. Very Large Array OH Zeeman Observations of the Star-forming Region S88B

    NASA Astrophysics Data System (ADS)

    Sarma, A. P.; Brogan, C. L.; Bourke, T. L.; Eftimova, M.; Troland, T. H.

    2013-04-01

    We present observations of the Zeeman effect in OH thermal absorption main lines at 1665 and 1667 MHz taken with the Very Large Array toward the star-forming region S88B. The OH absorption profiles toward this source are complicated, and contain several blended components toward a number of positions. Almost all of the OH absorbing gas is located in the eastern parts of S88B, toward the compact continuum source S88B-2 and the eastern parts of the extended continuum source S88B-1. The ratio of 1665/1667 MHz OH line intensities indicates the gas is likely highly clumped, in agreement with other molecular emission line observations in the literature. S88-B appears to present a similar geometry to the well-known star-forming region M17, in that there is an edge-on eastward progression from ionized to molecular gas. The detected magnetic fields appear to mirror this eastward transition; we detected line-of-sight magnetic fields ranging from 90 to 400 μG, with the lowest values of the field to the southwest of the S88B-1 continuum peak, and the highest values to its northeast. We used the detected fields to assess the importance of the magnetic field in S88B by a number of methods; we calculated the ratio of thermal to magnetic pressures, we calculated the critical field necessary to completely support the cloud against self-gravity and compared it to the observed field, and we calculated the ratio of mass to magnetic flux in terms of the critical value of this parameter. All these methods indicated that the magnetic field in S88B is dynamically significant, and should provide an important source of support against gravity. Moreover, the magnetic energy density is in approximate equipartition with the turbulent energy density, again pointing to the importance of the magnetic field in this region.

  11. BM88 is an early marker of proliferating precursor cells that will differentiate into the neuronal lineage.

    PubMed

    Koutmani, Yassemi; Hurel, Catherine; Patsavoudi, Evangelia; Hack, Michael; Gotz, Magdalena; Thomaidou, Dimitra; Matsas, Rebecca

    2004-11-01

    Progression of progenitor cells towards neuronal differentiation is tightly linked with cell cycle control and the switch from proliferative to neuron-generating divisions. We have previously shown that the neuronal protein BM88 drives neuroblastoma cells towards exit from the cell cycle and differentiation into a neuronal phenotype in vitro. Here, we explored the role of BM88 during neuronal birth, cell cycle exit and the initiation of differentiation in vivo. By double- and triple-labelling with the S-phase marker BrdU or the late G2 and M-phase marker cyclin B1, antibodies to BM88 and markers of the neuronal or glial cell lineages, we demonstrate that in the rodent forebrain, BM88 is expressed in multipotential progenitor cells before terminal mitosis and in their neuronal progeny during the neurogenic interval, as well as in the adult. Further, we defined at E16 a cohort of proliferative progenitors that exit S phase in synchrony, and by following their fate for 24 h we show that BM88 is associated with the dynamics of neuron-generating divisions. Expression of BM88 was also evident in cycling cortical radial glial cells, which constitute the main neurogenic population in the cerebral cortex. In agreement, BM88 expression was markedly reduced and restricted to a smaller percentage of cells in the cerebral cortex of the Small eye mutant mice, which lack functional Pax6 and exhibit severe neurogenesis defects. Our data show an interesting correlation between BM88 expression and the progression of progenitor cells towards neuronal differentiation during the neurogenic interval.

  12. Investigation of the polyvinyl alcohol stabilization mechanism and adsorption properties on the surface of ternary mixed nanooxide AST 50 (Al2O3-SiO2-TiO2)

    NASA Astrophysics Data System (ADS)

    Wiśniewska, Małgorzata; Ostolska, Iwona; Szewczuk-Karpisz, Katarzyna; Chibowski, Stanisław; Terpiłowski, Konrad; Gun'ko, Vladimir Moiseevich; Zarko, Vladimir Iljich

    2015-01-01

    A new adsorbent consisting of fumed, mixed alumina, silica, and titania in various proportions (AST 50) was investigated. The studied material was prepared by chemical vapor deposition method. The diameter of AST 50 primary particles was equal to about 51 nm which denotes that it can be classified as a nanomaterial. In the presented paper, the adsorption properties of polyvinyl alcohol on the ternary oxide were investigated. The polymer macromolecules were characterized by two different molecular weights and degree of hydrolysis. The polymer adsorption reaches the maximum at pH 3 and decreases with the solution pH rise. The reduction of the adsorbed PVA macromolecules is related to the electrostatic repulsion forces occurring in the studied system. The AST 50 point of zero charge (pHpzc) obtained from the potentiometric titration is equal to 4.7. Due to the nonionic character of the analyzed macromolecular compound, the polymer attendance has an insignificant effect on the AST 50 surface charge density. In the case of the adsorbent particles zeta potential, the obtained dependencies are different in the absence and presence of PVA. The shift of the slipping plane and displacement of the counter-ions from Stern layer by the adsorbed polymer chains have the greatest effect on the ζ potential value. The stability measurements indicate that the AST 50 suspensions in the presence of the background electrolyte at pH 3 and 6 are unstable. In turn, in an alkaline medium the mixed oxide suspensions exhibit the highest durability, which is a result of a large number of the negative charges on the AST 50 surface. The addition of PVA 100 significantly improves the suspension stability at pH 3 and 6; at higher pH value, the polymer presence does not influence the system durability. It is related to the steric and electrosteric stabilization of the colloidal particles by the adsorbed polyvinyl alcohol macromolecules.

  13. 7 CFR 3570.88 - Management assistance.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Management assistance. 3570.88 Section 3570.88 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF AGRICULTURE COMMUNITY PROGRAMS Community Facilities Grant Program § 3570.88 Management assistance. Grant...

  14. 7 CFR 3570.88 - Management assistance.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Management assistance. 3570.88 Section 3570.88 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF AGRICULTURE COMMUNITY PROGRAMS Community Facilities Grant Program § 3570.88 Management assistance. Grant...

  15. 7 CFR 3570.88 - Management assistance.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Management assistance. 3570.88 Section 3570.88 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF AGRICULTURE COMMUNITY PROGRAMS Community Facilities Grant Program § 3570.88 Management assistance. Grant...

  16. 7 CFR 3570.88 - Management assistance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Management assistance. 3570.88 Section 3570.88 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF AGRICULTURE COMMUNITY PROGRAMS Community Facilities Grant Program § 3570.88 Management assistance. Grant...

  17. 32 CFR 88.6 - Information requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Information requirements. 88.6 Section 88.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN TRANSITION ASSISTANCE FOR MILITARY PERSONNEL § 88.6 Information requirements. The quarterly report...

  18. 32 CFR 88.6 - Information requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Information requirements. 88.6 Section 88.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN TRANSITION ASSISTANCE FOR MILITARY PERSONNEL § 88.6 Information requirements. The quarterly report...

  19. 32 CFR 88.6 - Information requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Information requirements. 88.6 Section 88.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN TRANSITION ASSISTANCE FOR MILITARY PERSONNEL § 88.6 Information requirements. The quarterly report...

  20. 32 CFR 88.6 - Information requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Information requirements. 88.6 Section 88.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN TRANSITION ASSISTANCE FOR MILITARY PERSONNEL § 88.6 Information requirements. The quarterly report...

  1. 32 CFR 88.6 - Information requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Information requirements. 88.6 Section 88.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN TRANSITION ASSISTANCE FOR MILITARY PERSONNEL § 88.6 Information requirements. The quarterly report...

  2. Implementation and evaluation of the 5As framework of obesity management in primary care: design of the 5As Team (5AsT) randomized control trial.

    PubMed

    Campbell-Scherer, Denise L; Asselin, Jodie; Osunlana, Adedayo M; Fielding, Sheri; Anderson, Robin; Rueda-Clausen, Christian F; Johnson, Jeffrey A; Ogunleye, Ayodele A; Cave, Andrew; Manca, Donna; Sharma, Arya M

    2014-06-19

    Obesity is a pressing public health concern, which frequently presents in primary care. With the explosive obesity epidemic, there is an urgent need to maximize effective management in primary care. The 5As of Obesity Management™ (5As) are a collection of knowledge tools developed by the Canadian Obesity Network. Low rates of obesity management visits in primary care suggest provider behaviour may be an important variable. The goal of the present study is to increase frequency and quality of obesity management in primary care using the 5As Team (5AsT) intervention to change provider behaviour. The 5AsT trial is a theoretically informed, pragmatic randomized controlled trial with mixed methods evaluation. Clinic-based multidisciplinary teams (RN/NP, mental health, dietitians) will be randomized to control or the 5AsT intervention group, to participate in biweekly learning collaborative sessions supported by internal and external practice facilitation. The learning collaborative content addresses provider-identified barriers to effective obesity management in primary care. Evidence-based shared decision making tools will be co-developed and iteratively tested by practitioners. Evaluation will be informed by the RE-AIM framework. The primary outcome measure, to which participants are blinded, is number of weight management visits/full-time equivalent (FTE) position. Patient-level outcomes will also be assessed, through a longitudinal cohort study of patients from randomized practices. Patient outcomes include clinical (e.g., body mass index [BMI], blood pressure), health-related quality of life (SF-12, EQ5D), and satisfaction with care. Qualitative data collected from providers and patients will be evaluated using thematic analysis to understand the context, implementation and effectiveness of the 5AsT program. The 5AsT trial will provide a wide range of insights into current practices, knowledge gaps and barriers that limit obesity management in primary practice

  3. Advanced Subsonic Technology (AST) 22-Inch Low Noise Research Fan Rig Preliminary Design of ADP-Type Fan 3

    NASA Technical Reports Server (NTRS)

    Jeracki, Robert J. (Technical Monitor); Topol, David A.; Ingram, Clint L.; Larkin, Michael J.; Roche, Charles H.; Thulin, Robert D.

    2004-01-01

    This report presents results of the work completed on the preliminary design of Fan 3 of NASA s 22-inch Fan Low Noise Research project. Fan 3 was intended to build on the experience gained from Fans 1 and 2 by demonstrating noise reduction technology that surpasses 1992 levels by 6 dB. The work was performed as part of NASA s Advanced Subsonic Technology (AST) program. Work on this task was conducted in the areas of CFD code validation, acoustic prediction and validation, rotor parametric studies, and fan exit guide vane (FEGV) studies up to the time when a NASA decision was made to cancel the design, fabrication and testing phases of the work. The scope of the program changed accordingly to concentrate on two subtasks: (1) Rig data analysis and CFD code validation and (2) Fan and FEGV optimization studies. The results of the CFD code validation work showed that this tool predicts 3D flowfield features well from the blade trailing edge to about a chord downstream. The CFD tool loses accuracy as the distance from the trailing edge increases beyond a blade chord. The comparisons of noise predictions to rig test data showed that both the tone noise tool and the broadband noise tool demonstrated reasonable agreement with the data to the degree that these tools can reliably be used for design work. The section on rig airflow and inlet separation analysis describes the method used to determine total fan airflow, shows the good agreement of predicted boundary layer profiles to measured profiles, and shows separation angles of attack ranging from 29.5 to 27deg for the range of airflows tested. The results of the rotor parametric studies were significant in leading to the decision not to pursue a new rotor design for Fan 3 and resulted in recommendations to concentrate efforts on FEGV stator designs. The ensuing parametric study on FEGV designs showed the potential for 8 to 10 EPNdB noise reduction relative to the baseline.

  4. 21 CFR 500.88 - Regulatory method.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Regulatory method. 500.88 Section 500.88 Food and... § 500.88 Regulatory method. (a) The sponsor shall submit for evaluation and validation a regulatory method developed to monitor compliance with FDA's operational definition of no residue. (b) The...

  5. 21 CFR 500.88 - Regulatory method.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Regulatory method. 500.88 Section 500.88 Food and... § 500.88 Regulatory method. (a) The sponsor shall submit for evaluation and validation a regulatory method developed to monitor compliance with FDA's operational definition of no residue. (b) The...

  6. 21 CFR 500.88 - Regulatory method.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 6 2012-04-01 2012-04-01 false Regulatory method. 500.88 Section 500.88 Food and... § 500.88 Regulatory method. (a) The sponsor shall submit for evaluation and validation a regulatory method developed to monitor compliance with FDA's operational definition of no residue. (b) The...

  7. 21 CFR 500.88 - Regulatory method.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Regulatory method. 500.88 Section 500.88 Food and... § 500.88 Regulatory method. (a) The sponsor shall submit for evaluation and validation a regulatory method developed to monitor compliance with FDA's operational definition of no residue. (b) The...

  8. 21 CFR 500.88 - Regulatory method.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Regulatory method. 500.88 Section 500.88 Food and... § 500.88 Regulatory method. (a) The sponsor shall submit for evaluation and validation a regulatory method developed to monitor compliance with FDA's operational definition of no residue. (b) The...

  9. 9 CFR 88.2 - General information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false General information. 88.2 Section 88.2... EQUINES FOR SLAUGHTER § 88.2 General information. (a) State governments may enact and enforce regulations... transported the equines information regarding the business of that individual or other entity. When such...

  10. 19 CFR 141.88 - Computed value.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Computed value. 141.88 Section 141.88 Customs... (CONTINUED) ENTRY OF MERCHANDISE Invoices § 141.88 Computed value. When the port director determines that information as to computed value is necessary in the appraisement of any class or kind of merchandise, he...

  11. 9 CFR 381.88 - Parasites.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Parasites. 381.88 Section 381.88 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Post Mortem Inspection; Disposition of Carcasses and Parts...

  12. 45 CFR 88.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Definitions. 88.2 Section 88.2 Public Welfare... State and local governments, public and private institutions of higher education, public and private... governments, public and private institutions of higher education, public and private hospitals, commercial...

  13. 32 CFR 88.4 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Policy. 88.4 Section 88.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN TRANSITION... prepare separating Service members and their families with the skills, tools, and self-confidence...

  14. 32 CFR 88.4 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Policy. 88.4 Section 88.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN TRANSITION... prepare separating Service members and their families with the skills, tools, and self-confidence...

  15. 32 CFR 88.4 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Policy. 88.4 Section 88.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN TRANSITION... prepare separating Service members and their families with the skills, tools, and self-confidence...

  16. 32 CFR 88.4 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Policy. 88.4 Section 88.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN TRANSITION... prepare separating Service members and their families with the skills, tools, and self-confidence...

  17. 32 CFR 88.4 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Policy. 88.4 Section 88.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN TRANSITION... prepare separating Service members and their families with the skills, tools, and self-confidence...

  18. 42 CFR 88.1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Definitions. 88.1 Section 88.1 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND... Conditions (4) Cancers: This list includes those individual cancer types specified in Table 1, below...

  19. Investigation on the porosity of zeolite NU-88 by means of positron annihilation lifetime spectroscopy

    NASA Astrophysics Data System (ADS)

    Consolati, G.; Mariani, M.; Millini, R.; Quasso, F.

    2009-08-01

    Seven well characterized zeolites were investigated by positron annihilation lifetime spectroscopy. The lifetime spectra were analysed in four discrete components. The third one was associated with ortho-positronium annihilation in the channels, framed in terms of infinite cylinders. Differences between the radii determined from the positron annihilation technique and X-ray diffraction data were found and explained in terms of the physical structure of the channel. An analogous study on a high-silica NU-88 zeolite gave a value of 0.33 nm for the corresponding radius, in agreement with Ar and N 2 adsorption data as well as with the catalytic behaviour of this zeolite in several acid catalyzed reactions. The longest lifetime component in NU-88 reveals the existence of mesopores, with average radius of about 1.8 nm, which could explain the importance of hydrogen transfer reactions in this zeolite.

  20. Coastal Atmosphere and Sea Time Series (CoASTS)

    NASA Technical Reports Server (NTRS)

    Hooker, Stanford B. (Editor); Firestone, Elaine R. (Editor); Berthon, Jean-Francoise; Zibordi, Giuseppe; Doyle, John P.; Grossi, Stefania; vanderLinde, Dirk; Targa, Cristina; McClain, Charles R. (Technical Monitor)

    2002-01-01

    In this document, the first three years of a time series of bio-optical marine and atmospheric measurements are presented and analyzed. These measurements were performed from an oceanographic tower in the northern Adriatic Sea within the framework of the Coastal Atmosphere and Sea Time Series (CoASTS) project, an ocean color calibration and validation activity. The data set collected includes spectral measurements of the in-water apparent (diffuse attenuation coefficient, reflectance, Q-factor, etc.) and inherent (absorption and scattering coefficients) optical properties, as well as the concentrations of the main optical components (pigment and suspended matter concentrations). Clear seasonal patterns are exhibited by the marine quantities on which an appreciable short-term variability (on the order of a half day to one day) is superimposed. This short-term variability is well correlated with the changes in salinity at the surface resulting from the southward transport of freshwater coming from the northern rivers. Concentrations of chlorophyll alpha and total suspended matter span more than two orders of magnitude. The bio-optical characteristics of the measurement site pertain to both Case-I (about 64%) and Case-II (about 36%) waters, based on a relationship between the beam attenuation coefficient at 660nm and the chlorophyll alpha concentration. Empirical algorithms relating in-water remote sensing reflectance ratios and optical components or properties of interest (chlorophyll alpha, total suspended matter, and the diffuse attenuation coefficient) are presented.

  1. Why There Are 88 Keys on the Piano: "88 Logic-The Mackay Method for Piano." Volume 1

    ERIC Educational Resources Information Center

    Mackay, Stephen R.

    2005-01-01

    Background: After trying to define the reason why the piano ended up with 88 keys, I found patterns to explain ways of playing the piano with an 8:8 ratio which gives purpose to why the piano has 88 keys on it. Purpose: The first purpose is to enable piano teachers and music students to benefit from understanding how to play piano and be…

  2. Implementation and evaluation of the 5As framework of obesity management in primary care: design of the 5As Team (5AsT) randomized control trial

    PubMed Central

    2014-01-01

    Background Obesity is a pressing public health concern, which frequently presents in primary care. With the explosive obesity epidemic, there is an urgent need to maximize effective management in primary care. The 5As of Obesity Management™ (5As) are a collection of knowledge tools developed by the Canadian Obesity Network. Low rates of obesity management visits in primary care suggest provider behaviour may be an important variable. The goal of the present study is to increase frequency and quality of obesity management in primary care using the 5As Team (5AsT) intervention to change provider behaviour. Methods/design The 5AsT trial is a theoretically informed, pragmatic randomized controlled trial with mixed methods evaluation. Clinic-based multidisciplinary teams (RN/NP, mental health, dietitians) will be randomized to control or the 5AsT intervention group, to participate in biweekly learning collaborative sessions supported by internal and external practice facilitation. The learning collaborative content addresses provider-identified barriers to effective obesity management in primary care. Evidence-based shared decision making tools will be co-developed and iteratively tested by practitioners. Evaluation will be informed by the RE-AIM framework. The primary outcome measure, to which participants are blinded, is number of weight management visits/full-time equivalent (FTE) position. Patient-level outcomes will also be assessed, through a longitudinal cohort study of patients from randomized practices. Patient outcomes include clinical (e.g., body mass index [BMI], blood pressure), health-related quality of life (SF-12, EQ5D), and satisfaction with care. Qualitative data collected from providers and patients will be evaluated using thematic analysis to understand the context, implementation and effectiveness of the 5AsT program. Discussion The 5AsT trial will provide a wide range of insights into current practices, knowledge gaps and barriers that limit

  3. Molecular identification and functional analysis of two variants of myeloid differentiation factor 88 (MyD88) from disk abalone (Haliotis discus discus).

    PubMed

    Priyathilaka, Thanthrige Thiunuwan; Bathige, S D N K; Lee, Seongdo; Lee, Jehee

    2018-02-01

    Myeloid differentiation factor 88 (MyD88) is a crucial adaptor protein of the Toll-like receptor (TLR)- and interleukin 1 receptor-mediated signaling pathways and is involved in a diverse array of inflammatory responses via NF-κB activation. In the present study, two MyD88 variants were identified from disk abalone (Haliotis discus discus) and designated AbMyD88-2 and AbMyD88-X. The deduced AbMyD88-2 and AbMyD88-X comprised 433 and 354 amino acids with predicted molecular masses of 48.85 kDa and 40.17 kDa, respectively. AbMyD88-2 and AbMyD88-X possessed typical MyD88 domain structural features including an N-terminal death domain (DD) and C-terminal toll interleukin 1 receptor (TIR) domain similar to those in mammals. Expression analysis of AbMyD88-2 and AbMyD88-X mRNA at different early embryonic developmental stages of abalone by qPCR revealed that their constitutive expression at all developmental stages analyzed with the considerably higher values at the 16-cell (AbMyD88-2) and morula stages (AbMyD88-X). In unchallenged disk abalones, AbMyD88-2 was highly expressed in muscles, while AbMyD88-X mRNA was predominantly transcribed in hemocytes. Moreover, AbMyD88-2 and AbMyD88-X mRNA were differentially modulated in abalone hemocytes after a challenge with live bacteria (Vibrio parahaemolyticus, Listeria monocytogenes), virus (viral hemorrhagic septicemia virus), and pathogen-associated molecular patterns (lipopolysaccharides and Poly I:C). Overexpression of AbMyD88-2 and AbMyD88-X in HEK293T cells induced the activation of the NF-κB promoter. AbMyD88-2 and AbMyD88-X involvement in inflammatory responses was characterized by their overexpression in RAW264.7 murine macrophage cells. These results revealed comparatively higher NO (Nitric oxide) production, induction of inflammatory mediator genes (iNOS and COX2), and proinflammatory genes (IL1β, IL6 and TNFα) expression in abalone MyD88s-overexpressing cells than in mock control in the presence or absence of LPS

  4. Agreement in cardiovascular risk rating based on anthropometric parameters

    PubMed Central

    Dantas, Endilly Maria da Silva; Pinto, Cristiane Jordânia; Freitas, Rodrigo Pegado de Abreu; de Medeiros, Anna Cecília Queiroz

    2015-01-01

    Objective To investigate the agreement in evaluation of risk of developing cardiovascular diseases based on anthropometric parameters in young adults. Methods The study included 406 students, measuring weight, height, and waist and neck circumferences. Waist-to-height ratio and the conicity index. The kappa coefficient was used to assess agreement in risk classification for cardiovascular diseases. The positive and negative specific agreement values were calculated as well. The Pearson chi-square (χ2) test was used to assess associations between categorical variables (p<0.05). Results The majority of the parameters assessed (44%) showed slight (k=0.21 to 0.40) and/or poor agreement (k<0.20), with low values of negative specific agreement. The best agreement was observed between waist circumference and waist-to-height ratio both for the general population (k=0.88) and between sexes (k=0.93 to 0.86). There was a significant association (p<0.001) between the risk of cardiovascular diseases and females when using waist circumference and conicity index, and with males when using neck circumference. This resulted in a wide variation in the prevalence of cardiovascular disease risk (5.5%-36.5%), depending on the parameter and the sex that was assessed. Conclusion The results indicate variability in agreement in assessing risk for cardiovascular diseases, based on anthropometric parameters, and which also seems to be influenced by sex. Further studies in the Brazilian population are required to better understand this issue. PMID:26466060

  5. 88-Inch Cyclotron

    Science.gov Websites

    , commercial, and international institutions use these beams to understand the effect of radiation on microelectronics, optics, materials, and cells. Click here to see the 88-Inch Cyclotron's contributions to space

  6. 40 CFR 65.88-65.99 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false [Reserved] 65.88-65.99 Section 65.88-65.99 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONSOLIDATED FEDERAL AIR RULE Transfer Racks §§ 65.88-65.99 [Reserved] ...

  7. 7 CFR 989.88 - Duration of immunities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Duration of immunities. 989.88 Section 989.88... GROWN IN CALIFORNIA Order Regulating Handling Miscellaneous Provisions § 989.88 Duration of immunities. The benefits, privileges, and immunities conferred upon any person by virtue of this amended subpart...

  8. 7 CFR 989.88 - Duration of immunities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Duration of immunities. 989.88 Section 989.88... GROWN IN CALIFORNIA Order Regulating Handling Miscellaneous Provisions § 989.88 Duration of immunities. The benefits, privileges, and immunities conferred upon any person by virtue of this amended subpart...

  9. 7 CFR 989.88 - Duration of immunities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Duration of immunities. 989.88 Section 989.88... GROWN IN CALIFORNIA Order Regulating Handling Miscellaneous Provisions § 989.88 Duration of immunities. The benefits, privileges, and immunities conferred upon any person by virtue of this amended subpart...

  10. 7 CFR 989.88 - Duration of immunities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Duration of immunities. 989.88 Section 989.88... GROWN IN CALIFORNIA Order Regulating Handling Miscellaneous Provisions § 989.88 Duration of immunities. The benefits, privileges, and immunities conferred upon any person by virtue of this amended subpart...

  11. 7 CFR 989.88 - Duration of immunities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Duration of immunities. 989.88 Section 989.88... GROWN IN CALIFORNIA Order Regulating Handling Miscellaneous Provisions § 989.88 Duration of immunities. The benefits, privileges, and immunities conferred upon any person by virtue of this amended subpart...

  12. Observers' Agreement on Measurements in Fiberoptic Endoscopic Evaluation of Swallowing.

    PubMed

    Pilz, Walmari; Vanbelle, Sophie; Kremer, Bernd; van Hooren, Michel R; van Becelaere, Tine; Roodenburg, Nel; Baijens, Laura W J

    2016-04-01

    This study analyzed the effect that dysphagia etiology, different observers, and bolus consistency might have on the level of agreement for measurements in FEES images reached by independent versus consensus panel rating. Sixty patients were included and divided into two groups according to dysphagia etiology: neurological or head and neck oncological. All patients underwent standardized FEES examination using thin and thick liquid consistencies. Two observers scored the same exams, first independently and then in a consensus panel. Four ordinal FEES variables were analyzed. Statistical analysis was performed using a linear weighted kappa coefficient and Bayesian multilevel model. Intra- and interobserver agreement on FEES measurements ranged from 0.76 to 0.93 and from 0.61 to 0.88, respectively. Dysphagia etiology did not influence observers' agreement level. However, bolus consistency resulted in decreased interobserver agreement for all measured FEES variables during thin liquid swallows. When rating on the consensus panel, the observers deviated considerably from the scores they had previously given on the independent rating task. Observer agreement on measurements in FEES exams was influenced by bolus consistency, not by dysphagia etiology. Therefore, observer agreement on FEES measurements should be analyzed by taking bolus consistency into account, as it might affect the interpretation of the outcome. Identifying factors that might influence agreement levels could lead to better understanding of the rating process and assist in developing a more precise measurement scale that would ensure higher levels of observer agreement for measurements in FEES exams.

  13. 7 CFR 981.88 - Duration of immunities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Duration of immunities. 981.88 Section 981.88... Regulating Handling Miscellaneous Provisions § 981.88 Duration of immunities. The benefits, privileges, and immunities conferred upon any person by virtue of this subpart shall cease upon its termination except with...

  14. 7 CFR 981.88 - Duration of immunities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Duration of immunities. 981.88 Section 981.88... Regulating Handling Miscellaneous Provisions § 981.88 Duration of immunities. The benefits, privileges, and immunities conferred upon any person by virtue of this subpart shall cease upon its termination except with...

  15. 7 CFR 981.88 - Duration of immunities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Duration of immunities. 981.88 Section 981.88... Regulating Handling Miscellaneous Provisions § 981.88 Duration of immunities. The benefits, privileges, and immunities conferred upon any person by virtue of this subpart shall cease upon its termination except with...

  16. 7 CFR 981.88 - Duration of immunities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Duration of immunities. 981.88 Section 981.88... Regulating Handling Miscellaneous Provisions § 981.88 Duration of immunities. The benefits, privileges, and immunities conferred upon any person by virtue of this subpart shall cease upon its termination except with...

  17. 7 CFR 981.88 - Duration of immunities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Duration of immunities. 981.88 Section 981.88... Regulating Handling Miscellaneous Provisions § 981.88 Duration of immunities. The benefits, privileges, and immunities conferred upon any person by virtue of this subpart shall cease upon its termination except with...

  18. 40 CFR 87.83-87.88 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false [Reserved] 87.83-87.88 Section 87.83-87.88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) Definitions. Test Procedures for Engine Smoke Emissions (Aircraft Gas Turbine Engines) §§ 87.83-87.88...

  19. 42 CFR 32.88 - Examinations and treatment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Examinations and treatment. 32.88 Section 32.88... Hansen's Disease § 32.88 Examinations and treatment. Patients will be provided necessary clinical examinations which may be required for the diagnosis of primary or secondary conditions, and such treatment as...

  20. STS-88 Crew Portrait

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Five NASA astronauts and a Russian cosmonaut assigned to the STS-88 mission pose for a crew portrait. Seated in front (left to right) are mission specialists Sergei K. Krikalev, representing the Russian Space Agency (RSA), and astronaut Nancy J. Currie. In the rear from the left, are astronauts Jerry L. Ross, mission specialist; Robert D. Cabana, mission commander; Frederick W. 'Rick' Sturckow, pilot; and James H. Newman, mission specialist. The STS-88 mission launched aboard the Space Shuttle Endeavor on December 4, 1998 at 2:35 a.m. (CST) to deliver the Unity Node to the International Space Station (ISS).

  1. Planktic foraminifer census data from Northwind Ridge cores PI-88-AP P3, PI-88-AR P7 and PI-88-AR P9, Arctic Ocean

    USGS Publications Warehouse

    Foley, Kevin M.; Poore, Richard Z.

    1993-01-01

    The U.S. Geological Survey recovered 9 piston cores from the Northwind Ridge in the Canada Basin of the Arctic Ocean from a cruise of the USCGC Polar Star during 1988. Preliminary analysis of the cores suggests sediments deposited on Northwind Ridge preserve a detailed record of glacial and interglacial cycles for the last few hundred-thousand to one million years. This report includes quantitative data on foraminifers and selected sediment size-fraction data in 98 samples from Northwind Ridge core PI-88AR P3, 51 samples from core PI-88-AR P7 and 117 samples from core PI-88-AR P9.

  2. 7 CFR 800.88 - Loss of identity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Loss of identity. 800.88 Section 800.88 Agriculture... Methods and Procedures § 800.88 Loss of identity. (a) Lots. Except as noted in paragraph (d) of this... personnel performing a reinspection, appeal inspection, or Board appeal inspection service, the identity of...

  3. 7 CFR 800.88 - Loss of identity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Loss of identity. 800.88 Section 800.88 Agriculture... Methods and Procedures § 800.88 Loss of identity. (a) Lots. Except as noted in paragraph (d) of this... personnel performing a reinspection, appeal inspection, or Board appeal inspection service, the identity of...

  4. 7 CFR 800.88 - Loss of identity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Loss of identity. 800.88 Section 800.88 Agriculture... Methods and Procedures § 800.88 Loss of identity. (a) Lots. Except as noted in paragraph (d) of this... personnel performing a reinspection, appeal inspection, or Board appeal inspection service, the identity of...

  5. 7 CFR 800.88 - Loss of identity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 7 2013-01-01 2013-01-01 false Loss of identity. 800.88 Section 800.88 Agriculture... Methods and Procedures § 800.88 Loss of identity. (a) Lots. Except as noted in paragraph (d) of this... personnel performing a reinspection, appeal inspection, or Board appeal inspection service, the identity of...

  6. 7 CFR 800.88 - Loss of identity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false Loss of identity. 800.88 Section 800.88 Agriculture... Methods and Procedures § 800.88 Loss of identity. (a) Lots. Except as noted in paragraph (d) of this... personnel performing a reinspection, appeal inspection, or Board appeal inspection service, the identity of...

  7. 42 CFR 84.88 - Breathing bag test.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Apparatus § 84.88 Breathing bag test. (a) Breathing bags will be tested in an air atmosphere saturated with... Institute upon request. (d) The air within the bag(s) shall not contain more than 100 parts per million of... 42 Public Health 1 2014-10-01 2014-10-01 false Breathing bag test. 84.88 Section 84.88 Public...

  8. 27 CFR 6.88 - Equipment and supplies.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Equipment and supplies. 6.88 Section 6.88 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Exceptions § 6.88 Equipment and supplies. (a) General. The act by an industry member of selling equipmen...

  9. Home safety practices in an urban low-income population: level of agreement between parental self-report and observed behaviors.

    PubMed

    Lee, Lois K; Walia, Taranjeev; Forbes, Peter W; Osganian, Stavroula K; Samuels, Ronald; Cox, Joanne E; Mooney, David P

    2012-12-01

    Home-related injuries are overrepresented in children from low-income households. The objectives of this study were to determine frequencies of home safety behaviors and the level of agreement between parental self-report and observed safety practices in low-income homes. In a prospective, interventional home injury prevention study of 49 low-income families with children <5 years old, a trained home visitor administered baseline parental home safety behavior questionnaires and assessments. There was high agreement between caregiver self-report and home visitor observation for lack of cabinet latch (99%, 95% confidence interval [CI] = 88%-99%) and stair gate use (100%, 95% CI = 88-100%). There was lower agreement for the safe storage of cleaning supplies (62%, 95% CI = 46%-75%), sharps (74%, 95% CI = 59%-85%), and medicines/vitamins (83%, 95% CI = 69%-92%) because of the overreporting of safe practices. Self-reports of some home safety behaviors are relatively accurate, but certain practices may need to be verified by direct assessment.

  10. Gas exchange and lactate anaerobic thresholds: inter- and intraevaluator agreement.

    PubMed

    Gladden, L B; Yates, J W; Stremel, R W; Stamford, B A

    1985-06-01

    Twenty-four coded graph sets of gas exchange variables and blood lactate concentration (LA) plotted against time at 15-s intervals were analyzed by nine evaluators who determined the gas exchange (ATGE) and LA (ATLA) anaerobic thresholds. In addition, ATGE and ATLA were determined by a linear regression computer program. Agreement between ATGE and ATLA was poor; the median intraclass correlation coefficient (ri) was 0.53. Among evaluators, ATLA agreement (median ri = 0.81) was better than ATGE agreement (median ri = 0.70). In general, the ability of any evaluator to choose similar values from duplicate plots for either ATGE (median ri = 0.97) or ATLA (median ri = 0.995) was good. There was better agreement between the mean ATLA of the evaluators and the computer ATLA (ComLA) (ri = 0.88) than between the mean ATGE of the evaluators and the computer ATGE (ComVE), (ri = 0.58). Agreement between ComVE and ComLA was poor (ri = 0.29). These results suggest that ATGE does not accurately predict ATLA and that different evaluators choose different thresholds from the same data. Further assessment of the validity and precision of ATGE based on breath-by-breath and minute-by-minute data is needed.

  11. Multimethod, Multi-Informant Agreement, and Positive Predictive Value in the Identification of Child Anxiety Disorders Using the SCAS and ADIS-C

    ERIC Educational Resources Information Center

    Brown-Jacobsen, Amy M.; Wallace, Dustin P.; Whiteside, Stephen P. H.

    2011-01-01

    The current study sought to provide practical information for the clinical use of child and parent reports of child anxiety symptoms by investigating agreement between parent, child, and clinician as well as the predictive value of this information. Examining 88 anxious children and their parents, the study compared agreement by correlating parent…

  12. IFT88 influences chondrocyte actin organization and biomechanics.

    PubMed

    Wang, Z; Wann, A K T; Thompson, C L; Hassen, A; Wang, W; Knight, M M

    2016-03-01

    Primary cilia are microtubule based organelles which control a variety of signalling pathways important in cartilage development, health and disease. This study examines the role of the intraflagellar transport (IFT) protein, IFT88, in regulating fundamental actin organisation and mechanics in articular chondrocytes. The study used an established chondrocyte cell line with and without hypomorphic mutation of IFT88 (IFT88(orpk)). Confocal microscopy was used to quantify F-actin and myosin IIB organisation. Viscoelastic cell and actin cortex mechanics were determined using micropipette aspiration with actin dynamics visualised in live cells transfected with LifeACT-GFP. IFT88(orpk) cells exhibited a significant increase in acto-myosin stress fibre organisation relative to wild-type (WT) cells in monolayer and an altered response to cytochalasin D. Rounded IFT88(orpk) cells cultured in suspension exhibited reduced cortical actin expression with reduced cellular equilibrium modulus. Micropipette aspiration resulted in reduced membrane bleb formation in IFT88(orpk) cells. Following membrane blebbing, IFT88(orpk) cells exhibited slower reformation of the actin cortex. IFT88(orpk) cells showed increased actin deformability and reduced cortical tension confirming that IFT regulates actin cortex mechanics. The reduced cortical tension is also consistent with the reduced bleb formation. This study demonstrates for the first time that the ciliary protein IFT88 regulates fundamental actin organisation and the stiffness of the actin cortex leading to alterations in cell deformation, mechanical properties and blebbing in an IFT88 chondrocyte cell line. This adds to the growing understanding of the role of primary cilia and IFT in regulating cartilage biology. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  13. Dispensable role of myeloid differentiation primary response gene 88 (MyD88) and MyD88-dependent toll-like receptors (TLRs) in a murine model of osteoarthritis.

    PubMed

    Nasi, Sonia; Ea, Hang-Korng; Chobaz, Véronique; van Lent, Peter; Lioté, Frédéric; So, Alexander; Busso, Nathalie

    2014-07-01

    The aim of our study was to evaluate the role of cell-membrane expressed TLRs and the signaling molecule MyD88 in a murine model of OA induced by knee menisectomy (surgical partial removal of the medial meniscus [MNX]). OA was induced in 8-10weeks old C57Bl/6 wild-type (WT) female (n=7) mice and in knockout (KO) TLR-1 (n=7), -2 (n=8), -4 (n=9) -6 (n=5), MyD88 (n=8) mice by medial menisectomy, using the sham-operated contralateral knee as a control. Cartilage destruction and synovial inflammation were evaluated by knee joint histology using the OARSI scoring method. Apoptotic chondrocytes and cartilage metabolism (collagen II synthesis and MMP-mediated aggrecan degradation) were analyzed using immunohistochemistry. Operated knees exhibited OA features at 8weeks post-surgery compared to sham-operated ones. In menisectomized TLR-1, -2, -4, and -6 deficient mice, cartilage lesions, synovial inflammation and cartilage metabolism were similar to that in operated WT mice. Accordingly, using the same approach, we found no significant protection in MyD88-deficient mice in terms of OA progression as compared to WT littermates. Deficiency of TLRs or their signalling molecule MyD88 did not impact on the severity of experimental OA. Our results demonstrate that MyD88-dependent TLRs are not involved in this murine OA model. Moreover, the dispensable role of MyD88, which is also an adaptor for IL-1 receptor signaling, suggests that IL-1 is not a key mediator in the development of OA. This latter hypothesis is strengthened by the lack of efficiency of IL-1β antagonist in the treatment of OA. Copyright © 2014 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.

  14. 36 CFR 223.88 - Bidding methods.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Bidding methods. 223.88... Sale Contracts Advertisement and Bids § 223.88 Bidding methods. (a) Competitive sales of National Forest timber shall be offered through either sealed or oral auction bidding. The method chosen for each...

  15. 36 CFR 223.88 - Bidding methods.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Bidding methods. 223.88... Sale Contracts Advertisement and Bids § 223.88 Bidding methods. (a) Competitive sales of National Forest timber shall be offered through either sealed or oral auction bidding. The method chosen for each...

  16. 36 CFR 223.88 - Bidding methods.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Bidding methods. 223.88... Sale Contracts Advertisement and Bids § 223.88 Bidding methods. (a) Competitive sales of National Forest timber shall be offered through either sealed or oral auction bidding. The method chosen for each...

  17. 36 CFR 223.88 - Bidding methods.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Bidding methods. 223.88... Sale Contracts Advertisement and Bids § 223.88 Bidding methods. (a) Competitive sales of National Forest timber shall be offered through either sealed or oral auction bidding. The method chosen for each...

  18. 38 CFR 8.8 - Health requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Health requirements. 8.8... INSURANCE Reinstatement § 8.8 Health requirements. National Service life insurance on any plan may be... month for which the unpaid premium was due, provided the applicant be in as good health on the date of...

  19. 38 CFR 8.8 - Health requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Health requirements. 8.8... INSURANCE Reinstatement § 8.8 Health requirements. National Service life insurance on any plan may be... month for which the unpaid premium was due, provided the applicant be in as good health on the date of...

  20. 38 CFR 8.8 - Health requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Health requirements. 8.8... INSURANCE Reinstatement § 8.8 Health requirements. National Service life insurance on any plan may be... month for which the unpaid premium was due, provided the applicant be in as good health on the date of...

  1. 38 CFR 8.8 - Health requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Health requirements. 8.8... INSURANCE Reinstatement § 8.8 Health requirements. National Service life insurance on any plan may be... month for which the unpaid premium was due, provided the applicant be in as good health on the date of...

  2. 38 CFR 8.8 - Health requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Health requirements. 8.8... INSURANCE Reinstatement § 8.8 Health requirements. National Service life insurance on any plan may be... month for which the unpaid premium was due, provided the applicant be in as good health on the date of...

  3. 68Ga-PSMA-11 PET/CT Interobserver Agreement for Prostate Cancer Assessments: An International Multicenter Prospective Study.

    PubMed

    Fendler, Wolfgang Peter; Calais, Jeremie; Allen-Auerbach, Martin; Bluemel, Christina; Eberhardt, Nina; Emmett, Louise; Gupta, Pawan; Hartenbach, Markus; Hope, Thomas A; Okamoto, Shozo; Pfob, Christian Helmut; Pöppel, Thorsten D; Rischpler, Christoph; Schwarzenböck, Sarah; Stebner, Vanessa; Unterrainer, Marcus; Zacho, Helle D; Maurer, Tobias; Gratzke, Christian; Crispin, Alexander; Czernin, Johannes; Herrmann, Ken; Eiber, Matthias

    2017-10-01

    The interobserver agreement for 68 Ga-PSMA-11 PET/CT study interpretations in patients with prostate cancer is unknown. Methods: 68 Ga-PSMA-11 PET/CT was performed in 50 patients with prostate cancer for biochemical recurrence ( n = 25), primary diagnosis ( n = 10), biochemical persistence after primary therapy ( n = 5), or staging of known metastatic disease ( n = 10). Images were reviewed by 16 observers who used a standardized approach for interpretation of local (T), nodal (N), bone (Mb), or visceral (Mc) involvement. Observers were classified as having a low (<30 prior 68 Ga-PSMA-11 PET/CT studies; n = 5), intermediate (30-300 studies; n = 5), or high level of experience (>300 studies; n = 6). Histopathology ( n = 25, 50%), post-external-beam radiation therapy prostate-specific antigen response ( n = 15, 30%), or follow-up PET/CT ( n = 10, 20%) served as a standard of reference. Observer groups were compared by overall agreement (% patients matching the standard of reference) and Fleiss' κ with mean and corresponding 95% confidence interval (CI). Results: Agreement among all observers was substantial for T (κ = 0.62; 95% CI, 0.59-0.64) and N (κ = 0.74; 95% CI, 0.71-0.76) staging and almost perfect for Mb (κ = 0.88; 95% CI, 0.86-0.91) staging. Level of experience positively correlated with agreement for T (κ = 0.73/0.66/0.50 for high/intermediate/low experience, respectively), N (κ = 0.80/0.76/0.64, respectively), and Mc staging (κ = 0.61/0.46/0.36, respectively). Interobserver agreement for Mb was almost perfect irrespective of prior experience (κ = 0.87/0.91/0.88, respectively). Observers with low experience, when compared with intermediate and high experience, demonstrated significantly lower median overall agreement (54% vs. 66% and 76%, P = 0.041) and specificity for T staging (73% vs. 88% and 93%, P = 0.032). Conclusion: The interpretation of 68 Ga-PSMA-11 PET/CT for prostate cancer staging is highly consistent among observers with high levels of

  4. 32 CFR 776.88 - Report to licensing authorities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Report to licensing authorities. 776.88 Section 776.88 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES... Complaint Processing Procedures § 776.88 Report to licensing authorities. Upon determination by JAG that a...

  5. 32 CFR 776.88 - Report to licensing authorities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Report to licensing authorities. 776.88 Section 776.88 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES... Complaint Processing Procedures § 776.88 Report to licensing authorities. Upon determination by JAG that a...

  6. 32 CFR 776.88 - Report to licensing authorities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Report to licensing authorities. 776.88 Section 776.88 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES... Complaint Processing Procedures § 776.88 Report to licensing authorities. Upon determination by JAG that a...

  7. 10 CFR 110.88 - Authority of the Secretary.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Authority of the Secretary. 110.88 Section 110.88 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Public Participation Procedures Concerning License Applications § 110.88 Authority of the Secretary. The Secretary is...

  8. 10 CFR 110.88 - Authority of the Secretary.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Authority of the Secretary. 110.88 Section 110.88 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Public Participation Procedures Concerning License Applications § 110.88 Authority of the Secretary. The Secretary is...

  9. 26 CFR 1.88-1 - Nuclear decommissioning costs.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 2 2011-04-01 2011-04-01 false Nuclear decommissioning costs. 1.88-1 Section 1... (CONTINUED) INCOME TAXES (CONTINUED) Items Specifically Included in Gross Income § 1.88-1 Nuclear decommissioning costs. (a) In general. Section 88 provides that the amount of nuclear decommissioning costs...

  10. 26 CFR 1.88-1 - Nuclear decommissioning costs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 2 2013-04-01 2013-04-01 false Nuclear decommissioning costs. 1.88-1 Section 1... (CONTINUED) INCOME TAXES (CONTINUED) Items Specifically Included in Gross Income § 1.88-1 Nuclear decommissioning costs. (a) In general. Section 88 provides that the amount of nuclear decommissioning costs...

  11. 26 CFR 1.88-1 - Nuclear decommissioning costs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 2 2012-04-01 2012-04-01 false Nuclear decommissioning costs. 1.88-1 Section 1... (CONTINUED) INCOME TAXES (CONTINUED) Items Specifically Included in Gross Income § 1.88-1 Nuclear decommissioning costs. (a) In general. Section 88 provides that the amount of nuclear decommissioning costs...

  12. 26 CFR 1.88-1 - Nuclear decommissioning costs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Nuclear decommissioning costs. 1.88-1 Section 1... (CONTINUED) INCOME TAXES (CONTINUED) Items Specifically Included in Gross Income § 1.88-1 Nuclear decommissioning costs. (a) In general. Section 88 provides that the amount of nuclear decommissioning costs...

  13. 26 CFR 1.88-1 - Nuclear decommissioning costs.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 2 2014-04-01 2014-04-01 false Nuclear decommissioning costs. 1.88-1 Section 1... (CONTINUED) INCOME TAXES (CONTINUED) Items Specifically Included in Gross Income § 1.88-1 Nuclear decommissioning costs. (a) In general. Section 88 provides that the amount of nuclear decommissioning costs...

  14. 42 CFR 408.88 - Refund of group payments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false Refund of group payments. 408.88 Section 408.88... PROGRAM PREMIUMS FOR SUPPLEMENTARY MEDICAL INSURANCE Direct Remittance: Group Payment § 408.88 Refund of group payments. (a) Basis for refund. Group payments are refunded only in the following circumstances...

  15. 42 CFR 408.88 - Refund of group payments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false Refund of group payments. 408.88 Section 408.88... PROGRAM PREMIUMS FOR SUPPLEMENTARY MEDICAL INSURANCE Direct Remittance: Group Payment § 408.88 Refund of group payments. (a) Basis for refund. Group payments are refunded only in the following circumstances...

  16. 42 CFR 408.88 - Refund of group payments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false Refund of group payments. 408.88 Section 408.88... PROGRAM PREMIUMS FOR SUPPLEMENTARY MEDICAL INSURANCE Direct Remittance: Group Payment § 408.88 Refund of group payments. (a) Basis for refund. Group payments are refunded only in the following circumstances...

  17. 42 CFR 408.88 - Refund of group payments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Refund of group payments. 408.88 Section 408.88... PROGRAM PREMIUMS FOR SUPPLEMENTARY MEDICAL INSURANCE Direct Remittance: Group Payment § 408.88 Refund of group payments. (a) Basis for refund. Group payments are refunded only in the following circumstances...

  18. 42 CFR 408.88 - Refund of group payments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Refund of group payments. 408.88 Section 408.88... PROGRAM PREMIUMS FOR SUPPLEMENTARY MEDICAL INSURANCE Direct Remittance: Group Payment § 408.88 Refund of group payments. (a) Basis for refund. Group payments are refunded only in the following circumstances...

  19. 48 CFR 552.211-88 - Vehicle export preparation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Vehicle export preparation. 552.211-88 Section 552.211-88 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 552.211-88 Vehicle export preparation. As prescribed...

  20. 21 CFR 520.88 - Amoxicillin oral dosage forms.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Amoxicillin oral dosage forms. 520.88 Section 520.88 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.88 Amoxicillin oral...

  1. 21 CFR 520.88 - Amoxicillin oral dosage forms.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Amoxicillin oral dosage forms. 520.88 Section 520.88 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.88 Amoxicillin oral...

  2. 21 CFR 520.88 - Amoxicillin oral dosage forms.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Amoxicillin oral dosage forms. 520.88 Section 520.88 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.88 Amoxicillin oral...

  3. 21 CFR 520.88 - Amoxicillin oral dosage forms.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Amoxicillin oral dosage forms. 520.88 Section 520.88 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.88 Amoxicillin oral...

  4. Patient-Proxy Agreement on the Health-Related Quality of Life One Year After Traumatic Brain Injury.

    PubMed

    Hwang, Hei-Fen; Chen, Chih-Yi; Lin, Mau-Roung

    2017-12-01

    To examine the level of agreement between patients and their proxies on a measure of health-related quality of life (HRQL) 1 year after traumatic brain injury (TBI). A cross-sectional study. Four hospitals in Taipei. Participants (N=176) were patients with TBI (n=88) identified from discharge records of 4 hospitals in Taiwan and family members or friends (n=88) who could answer questions regarding the patient's health and HRQL 1 year after the injury. Not applicable. A health profile of the brief Taiwanese version of the World Health Organization Quality of Life (WHOQOL-BREF) and 2 health utility measures of the time tradeoff (TTO) and standard gamble (SG). Compared with proxy responses, patients provided higher ratings on the domains of the WHOQOL-BREF and lower ratings on the TTO and SG. Intraclass correlation coefficients between patient and proxy ratings varied among the 4 domains of the WHOQOL-BREF, in which levels of agreement were moderate or good for physical capacity (.69) and low for psychological well-being (.45), social relationships (.24), and the environment (.32). Levels of agreement were extremely low for the TTO (0.0) and SG (.10). A profile analysis showed that patients' ratings on the WHOQOL-BREF, on average, were significantly greater than those of their proxies (mean difference, 3.07), with a similar distribution of scatter responses (mean difference, .002) and shape agreement (mean difference, .57). Greater variations in the patient-proxy level of agreement appeared in patients who were younger and had more severe injuries, and also with parent and child proxies. To assess the HRQL of patients with a TBI, the level of patient-proxy agreement was adequate for the physical domain but was lower for the social and environmental domains, and the agreement was very low for the TTO and SG. Furthermore, a patient's age and injury severity, and the patient-proxy' relationship may affect the agreement. Copyright © 2017 American Congress of

  5. 10 CFR 71.88 - Air transport of plutonium.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Air transport of plutonium. 71.88 Section 71.88 Energy... Controls and Procedures § 71.88 Air transport of plutonium. (a) Notwithstanding the provisions of any..., whether for import, export, or domestic shipment, is not transported by air or delivered to a carrier for...

  6. 10 CFR 71.88 - Air transport of plutonium.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Air transport of plutonium. 71.88 Section 71.88 Energy... Controls and Procedures § 71.88 Air transport of plutonium. (a) Notwithstanding the provisions of any..., whether for import, export, or domestic shipment, is not transported by air or delivered to a carrier for...

  7. 10 CFR 71.88 - Air transport of plutonium.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Air transport of plutonium. 71.88 Section 71.88 Energy... Controls and Procedures § 71.88 Air transport of plutonium. (a) Notwithstanding the provisions of any..., whether for import, export, or domestic shipment, is not transported by air or delivered to a carrier for...

  8. 10 CFR 71.88 - Air transport of plutonium.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Air transport of plutonium. 71.88 Section 71.88 Energy... Controls and Procedures § 71.88 Air transport of plutonium. (a) Notwithstanding the provisions of any..., whether for import, export, or domestic shipment, is not transported by air or delivered to a carrier for...

  9. 10 CFR 71.88 - Air transport of plutonium.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Air transport of plutonium. 71.88 Section 71.88 Energy... Controls and Procedures § 71.88 Air transport of plutonium. (a) Notwithstanding the provisions of any..., whether for import, export, or domestic shipment, is not transported by air or delivered to a carrier for...

  10. 29 CFR 452.88 - Resumption of good standing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... DISCLOSURE ACT OF 1959 Right To Vote § 452.88 Resumption of good standing. While it is permissible for a labor organization to deny the right to vote to those delinquent in paying their dues (with the... 29 Labor 2 2010-07-01 2010-07-01 false Resumption of good standing. 452.88 Section 452.88 Labor...

  11. 10 CFR 51.88 - Proposals for legislation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Proposals for legislation. 51.88 Section 51.88 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2...

  12. 9 CFR 88.4 - Requirements for transport.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Section 88.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS COMMERCIAL TRANSPORTATION OF EQUINES FOR SLAUGHTER § 88.4 Requirements for transport. (a) Prior to the commercial...

  13. 9 CFR 88.4 - Requirements for transport.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Section 88.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS COMMERCIAL TRANSPORTATION OF EQUINES FOR SLAUGHTER § 88.4 Requirements for transport. (a) Prior to the commercial...

  14. 9 CFR 88.4 - Requirements for transport.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Section 88.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS COMMERCIAL TRANSPORTATION OF EQUINES FOR SLAUGHTER § 88.4 Requirements for transport. (a) Prior to the commercial...

  15. 9 CFR 88.4 - Requirements for transport.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Section 88.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS COMMERCIAL TRANSPORTATION OF EQUINES FOR SLAUGHTER § 88.4 Requirements for transport. (a) Prior to the commercial...

  16. 9 CFR 88.4 - Requirements for transport.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Section 88.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS COMMERCIAL TRANSPORTATION OF EQUINES FOR SLAUGHTER § 88.4 Requirements for transport. (a) Prior to the commercial...

  17. MYD88 L265P mutation in Waldenstrom macroglobulinemia.

    PubMed

    Poulain, Stéphanie; Roumier, Christophe; Decambron, Audrey; Renneville, Aline; Herbaux, Charles; Bertrand, Elisabeth; Tricot, Sabine; Daudignon, Agnès; Galiègue-Zouitina, Sylvie; Soenen, Valerie; Theisen, Olivier; Grardel, Nathalie; Nibourel, Olivier; Roche-Lestienne, Catherine; Quesnel, Bruno; Duthilleul, Patrick; Preudhomme, Claude; Leleu, Xavier

    2013-05-30

    Mutation of the MYD88 gene has recently been identified in activated B-cell-like diffuse cell lymphoma and enhanced Janus kinase/signal transducer and activator of transcription (JAK-STAT) and nuclear factor κB (NF-κB) signaling pathways. A whole exome-sequencing study of Waldenstrom macroglobulinemia (WM) suggested a high frequency of MYD88 L265P mutation in WM. The genetic background is not fully deciphered in WM, although the role of NF-κB and JAK-STAT has been demonstrated. We analyzed MYD88 mutation in exon 5 and characterized the clinical significance of this genetic alteration in 67 WM patients. Clinical features; immunophenotypic markers; and conventional cytogenetic, fluorescence in situ hybridization, and single nucleotide polymorphism array data were analyzed. MYD88 L265P mutation was acquired in 79% of patients. Overall, we have identified alteration of the MYD88 locus in 91% of WM patients, including 12% with gain on chromosome 3 at the 3p22 locus that included the MYD88 gene. Patients with absence of MYD88 mutation were WM characterized with a female predominance, a splenomegaly, gain of chromosome 3, and CD27 expression. Importantly, inhibition of MYD88 signaling induced cytotoxicity and inhibited cell growth of cell lines issued from patients with WM. In conclusion, these results confirm a high frequency of MYD88 L265P mutation in WM. The discovery of MYD88 L265P mutation may contribute to a better understanding of the physiopathogeny of WM.

  18. 27 CFR 479.88 - Special (occupational) taxpayers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2014-04-01 2014-04-01 false Special (occupational) taxpayers. 479.88 Section 479.88 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES...

  19. 27 CFR 479.88 - Special (occupational) taxpayers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2013-04-01 2013-04-01 false Special (occupational) taxpayers. 479.88 Section 479.88 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES...

  20. 27 CFR 479.88 - Special (occupational) taxpayers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2011-04-01 2010-04-01 true Special (occupational) taxpayers. 479.88 Section 479.88 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES...

  1. 27 CFR 479.88 - Special (occupational) taxpayers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Special (occupational) taxpayers. 479.88 Section 479.88 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES...

  2. 27 CFR 479.88 - Special (occupational) taxpayers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2012-04-01 2010-04-01 true Special (occupational) taxpayers. 479.88 Section 479.88 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES...

  3. Oncogenically active MYD88 mutations in human lymphoma.

    PubMed

    Ngo, Vu N; Young, Ryan M; Schmitz, Roland; Jhavar, Sameer; Xiao, Wenming; Lim, Kian-Huat; Kohlhammer, Holger; Xu, Weihong; Yang, Yandan; Zhao, Hong; Shaffer, Arthur L; Romesser, Paul; Wright, George; Powell, John; Rosenwald, Andreas; Muller-Hermelink, Hans Konrad; Ott, German; Gascoyne, Randy D; Connors, Joseph M; Rimsza, Lisa M; Campo, Elias; Jaffe, Elaine S; Delabie, Jan; Smeland, Erlend B; Fisher, Richard I; Braziel, Rita M; Tubbs, Raymond R; Cook, J R; Weisenburger, Denny D; Chan, Wing C; Staudt, Louis M

    2011-02-03

    The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) remains the least curable form of this malignancy despite recent advances in therapy. Constitutive nuclear factor (NF)-κB and JAK kinase signalling promotes malignant cell survival in these lymphomas, but the genetic basis for this signalling is incompletely understood. Here we describe the dependence of ABC DLBCLs on MYD88, an adaptor protein that mediates toll and interleukin (IL)-1 receptor signalling, and the discovery of highly recurrent oncogenic mutations affecting MYD88 in ABC DLBCL tumours. RNA interference screening revealed that MYD88 and the associated kinases IRAK1 and IRAK4 are essential for ABC DLBCL survival. High-throughput RNA resequencing uncovered MYD88 mutations in ABC DLBCL lines. Notably, 29% of ABC DLBCL tumours harboured the same amino acid substitution, L265P, in the MYD88 Toll/IL-1 receptor (TIR) domain at an evolutionarily invariant residue in its hydrophobic core. This mutation was rare or absent in other DLBCL subtypes and Burkitt's lymphoma, but was observed in 9% of mucosa-associated lymphoid tissue lymphomas. At a lower frequency, additional mutations were observed in the MYD88 TIR domain, occurring in both the ABC and germinal centre B-cell-like (GCB) DLBCL subtypes. Survival of ABC DLBCL cells bearing the L265P mutation was sustained by the mutant but not the wild-type MYD88 isoform, demonstrating that L265P is a gain-of-function driver mutation. The L265P mutant promoted cell survival by spontaneously assembling a protein complex containing IRAK1 and IRAK4, leading to IRAK4 kinase activity, IRAK1 phosphorylation, NF-κB signalling, JAK kinase activation of STAT3, and secretion of IL-6, IL-10 and interferon-β. Hence, the MYD88 signalling pathway is integral to the pathogenesis of ABC DLBCL, supporting the development of inhibitors of IRAK4 kinase and other components of this pathway for the treatment of tumours bearing oncogenic MYD88 mutations.

  4. 40 CFR 87.83-87.88 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false [Reserved] 87.83-87.88 Section 87.83-87.88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM AIRCRAFT AND AIRCRAFT ENGINES Test Procedures for Engine Smoke Emissions...

  5. 40 CFR 87.83-87.88 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false [Reserved] 87.83-87.88 Section 87.83-87.88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM AIRCRAFT AND AIRCRAFT ENGINES Test Procedures for Engine Smoke Emissions...

  6. 42 CFR 84.88 - Breathing bag test.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Breathing bag test. 84.88 Section 84.88 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing...

  7. 42 CFR 84.88 - Breathing bag test.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Breathing bag test. 84.88 Section 84.88 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing...

  8. 42 CFR 84.88 - Breathing bag test.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Breathing bag test. 84.88 Section 84.88 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing...

  9. 42 CFR 84.88 - Breathing bag test.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Breathing bag test. 84.88 Section 84.88 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing...

  10. 47 CFR 1.88 - Predesignation pleading procedure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Predesignation pleading procedure. 1.88 Section... Rules of Practice and Procedure Miscellaneous Proceedings § 1.88 Predesignation pleading procedure. In... staff, in its discretion, may in writing, advise such licensee of the general nature of the...

  11. 45 CFR 88.4 - Requirements and prohibitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Requirements and prohibitions. 88.4 Section 88.4... his religious beliefs or moral convictions, or because of his religious beliefs or moral convictions... or consistent with the applicant's religious beliefs or moral convictions. (d) Entities to whom this...

  12. 14 CFR 34.83-34.88 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false [Reserved] 34.83-34.88 Section 34.83-34.88 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT FUEL VENTING AND EXHAUST EMISSION REQUIREMENTS FOR TURBINE ENGINE POWERED AIRPLANES Test Procedures for Engine Smoke...

  13. Dupuytren’s and Ledderhose Diseases in a Family with LMNA-Related Cardiomyopathy and a Novel Variant in the ASTE1 Gene

    PubMed Central

    Zaragoza, Michael V.; Nguyen, Cecilia H. H.; Widyastuti, Halida P.; McCarthy, Linda A.; Grosberg, Anna

    2017-01-01

    Dupuytren’s disease (palmar fibromatosis) involves nodules in fascia of the hand that leads to flexion contractures. Ledderhose disease (plantar fibromatosis) is similar with nodules of the foot. While clinical aspects are well-described, genetic mechanisms are unknown. We report a family with cardiac disease due to a heterozygous LMNA mutation (c.736C>T, p.Gln246Stop) with palmar/plantar fibromatosis and investigate the hypothesis that a second rare DNA variant increases the risk for fibrotic disease in LMNA mutation carriers. The proband and six family members were evaluated for the cardiac and hand/feet phenotypes and tested for the LMNA mutation. Fibroblast RNA studies revealed monoallelic expression of the normal LMNA allele and reduced lamin A/C mRNAs consistent with LMNA haploinsufficiency. A novel, heterozygous missense variant (c.230T>C, p.Val77Ala) in the Asteroid Homolog 1 (ASTE1) gene was identified as a potential risk factor in fibrotic disease using exome sequencing and family studies of five family members: four LMNA mutation carriers with fibromatosis and one individual without the LMNA mutation and no fibromatosis. With a possible role in epidermal growth factor receptor signaling, ASTE1 may contribute to the increased risk for palmar/plantar fibromatosis in patients with Lamin A/C haploinsufficiency. PMID:29104234

  14. 14 CFR 33.88 - Engine overtemperature test.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Block Tests; Turbine Aircraft Engines § 33.88 Engine overtemperature test. (a) Each engine must run for 5 minutes at maximum permissible rpm with the gas temperature at... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Engine overtemperature test. 33.88 Section...

  15. 38 CFR 11.88 - Cancellation of note.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Certificates Redeemed from Banks by the Department of Veterans Affairs Under Section 502 of the World War... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Cancellation of note. 11.88 Section 11.88 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS LOANS BY...

  16. 38 CFR 11.88 - Cancellation of note.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Certificates Redeemed from Banks by the Department of Veterans Affairs Under Section 502 of the World War... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Cancellation of note. 11.88 Section 11.88 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS LOANS BY...

  17. 38 CFR 11.88 - Cancellation of note.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Certificates Redeemed from Banks by the Department of Veterans Affairs Under Section 502 of the World War... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Cancellation of note. 11.88 Section 11.88 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS LOANS BY...

  18. 38 CFR 11.88 - Cancellation of note.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Certificates Redeemed from Banks by the Department of Veterans Affairs Under Section 502 of the World War... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Cancellation of note. 11.88 Section 11.88 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS LOANS BY...

  19. 38 CFR 11.88 - Cancellation of note.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Certificates Redeemed from Banks by the Department of Veterans Affairs Under Section 502 of the World War... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Cancellation of note. 11.88 Section 11.88 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS LOANS BY...

  20. 7 CFR 1212.88 - OMB control number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false OMB control number. 1212.88 Section 1212.88 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Management and Budget pursuant to the Paperwork Reduction Act of 1995, 44 U.S.C. Chapter 35, is OMB control...

  1. 14 CFR 33.88 - Engine overtemperature test.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Engine overtemperature test. 33.88 Section... AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Block Tests; Turbine Aircraft Engines § 33.88 Engine overtemperature test. (a) Each engine must run for 5 minutes at maximum permissible rpm with the gas temperature at...

  2. 40 CFR 745.88 - Recognized test kits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Recognized test kits. 745.88 Section... Renovation § 745.88 Recognized test kits. (a) Effective June 23, 2008, EPA recognizes the test kits that have been determined by National Institute of Standards and Technology research to meet the negative...

  3. 40 CFR 745.88 - Recognized test kits.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Recognized test kits. 745.88 Section... Renovation § 745.88 Recognized test kits. (a) Effective June 23, 2008, EPA recognizes the test kits that have been determined by National Institute of Standards and Technology research to meet the negative...

  4. 40 CFR 745.88 - Recognized test kits.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Recognized test kits. 745.88 Section... Renovation § 745.88 Recognized test kits. (a) Effective June 23, 2008, EPA recognizes the test kits that have been determined by National Institute of Standards and Technology research to meet the negative...

  5. 40 CFR 745.88 - Recognized test kits.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Recognized test kits. 745.88 Section... Renovation § 745.88 Recognized test kits. (a) Effective June 23, 2008, EPA recognizes the test kits that have been determined by National Institute of Standards and Technology research to meet the negative...

  6. 20 CFR 632.88 - General responsibilities of the Department.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false General responsibilities of the Department. 632.88 Section 632.88 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR INDIAN AND NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Program Design and Management § 632.88...

  7. Molecular dynamics simulations on the conformational transitions from the GA 98 (GA 88) to GB 98 (GB 88) proteins.

    PubMed

    Song, Chunnian; Wang, Qing; Xue, Tuo; Wang, Yan; Chen, Guangju

    2016-12-01

    We performed conventional and targeted molecular dynamics simulations to address the dynamic transition mechanisms of the conformational transitions from the G A 98 protein with only 1 mutation of Leu45Tyr to G B 98 and from the G A 88 protein with 7 mutations of Gly24Ala, Ile25Thr, Ile30Phe, Ile33Tyr, Leu45Tyr, Ile49Thr, and Leu50Lys to G B 88. The results show that the conformational transition mechanism from the mutated 3α G A 98 (G A 88) state to the α+4β G B 98 (G B 88) state via several intermediate conformations involves the bending of loops at the N and C termini firstly, the unfolding of αA and αC, then the traversing of αB, and the formation of the 4β layer with the conversion of the hydrophobic core. The bending of loops at the N and C termini and the formation of the crucial transition conformation with the full unfolded structure are key factors in their transition processes. The communication of the interaction network, the bending directions of loops, and the traversing site of αB in the transition of G A 98 to G B 98 are markedly different from those in G A 88 to G B 88 because of the different mutated residues. The analysis of the correlations and the calculated mass center distances between some segments further supported their conformational transition mechanisms. These results could help people to better understand the Paracelsus challenge. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  8. 7 CFR 1779.88 - Transfers and assumptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... borrowers will include a one-time nonrefundable transfer fee to the Agency of no more than 1 percent... reasonable debt-paying ability considering their assets and income at the time of transfer, and (ii) The... 7 Agriculture 12 2013-01-01 2013-01-01 false Transfers and assumptions. 1779.88 Section 1779.88...

  9. Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate.

    PubMed

    Tian, Hua; Feng, Jifan; Li, Jingyuan; Ho, Thach-Vu; Yuan, Yuan; Liu, Yang; Brindopke, Frederick; Figueiredo, Jane C; Magee, William; Sanchez-Lara, Pedro A; Chai, Yang

    2017-03-01

    Ciliopathies are pleiotropic human diseases resulting from defects of the primary cilium, and these patients often have cleft lip and palate. IFT88 is required for the assembly and function of the primary cilia, which mediate the activity of key developmental signaling pathways. Through whole exome sequencing of a family of three affected siblings with isolated cleft lip and palate, we discovered that they share a novel missense mutation in IFT88 (c.915G > C, p.E305D), suggesting this gene should be considered a candidate for isolated orofacial clefting. In order to evaluate the function of IFT88 in regulating craniofacial development, we generated Wnt1-Cre;Ift88fl/fl mice to eliminate Ift88 specifically in cranial neural crest (CNC) cells. Wnt1-Cre;Ift88fl/flpups died at birth due to severe craniofacial defects including bilateral cleft lip and palate and tongue agenesis, following the loss of the primary cilia in the CNC-derived palatal mesenchyme. Loss of Ift88 also resulted in a decrease in neural crest cell proliferation during early stages of palatogenesis as well as a downregulation of the Shh signaling pathway in the palatal mesenchyme. Importantly, Osr2KI-Cre;Ift88fl/flmice, in which Ift88 is lost specifically in the palatal mesenchyme, exhibit isolated cleft palate. Taken together, our results demonstrate that IFT88 has a highly conserved function within the primary cilia of the CNC-derived mesenchyme in the lip and palate region in mice and is a strong candidate as an orofacial clefting gene in humans. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  10. 40 CFR 745.88 - Recognized test kits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Recognized test kits. 745.88 Section... Renovation § 745.88 Recognized test kits. (a) Effective June 23, 2008, EPA recognizes the test kits that have... publicizes its recognition of the first test kit that meets both the negative response and positive response...

  11. 21 CFR 526.88 - Amoxicillin trihydrate for intramammary infusion.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Amoxicillin trihydrate for intramammary infusion. 526.88 Section 526.88 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... § 526.88 Amoxicillin trihydrate for intramammary infusion. (a) Specifications. Each single dose syringe...

  12. 18 CFR 401.88 - Findings, report and Commission review.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Findings, report and Commission review. 401.88 Section 401.88 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Administrative and Other Hearings § 401.88...

  13. Wide-field Imaging Survey of Dust Continuum Emissions at lambda = 1.1 mm toward the Chamaeleon and Lupus Regions with AzTEC on ASTE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Momose, Munetake; Hiramatsu, Masaaki; Tsukagoshi, Takashi

    2009-08-05

    We carried out an imaging survey of dust continuum emissions toward the Chamaeleon and Lupus regions. Observations were made with the 144-element bolometer array camera AzTEC mounted on the 10-meter sub-millimeter telescope ASTE during 2007-2008. The preliminary results of disk search and the cloud structure of Lupus III are presented.

  14. 40 CFR 86.603-88 - Test orders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 20 2012-07-01 2012-07-01 false Test orders. 86.603-88 Section 86.603... Auditing of New Light-Duty Vehicles, Light-Duty Trucks, and Heavy-Duty Vehicles § 86.603-88 Test orders. (a) The Administrator will require any testing under this subpart by means of a test order addressed to...

  15. 40 CFR 86.603-88 - Test orders.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 19 2014-07-01 2014-07-01 false Test orders. 86.603-88 Section 86.603... New Light-Duty Vehicles, Light-Duty Trucks, and Heavy-Duty Vehicles § 86.603-88 Test orders. (a) The Administrator will require any testing under this subpart by means of a test order addressed to the manufacturer...

  16. Microbial identification and automated antibiotic susceptibility testing directly from positive blood cultures using MALDI-TOF MS and VITEK 2.

    PubMed

    Wattal, C; Oberoi, J K

    2016-01-01

    The study addresses the utility of Matrix Assisted Laser Desorption/Ionisation Time-Of-Flight mass spectrometry (MALDI-TOF MS) using VITEK MS and the VITEK 2 antimicrobial susceptibility testing (AST) system for direct identification (ID) and timely AST from positive blood culture bottles using a lysis-filtration method (LFM). Between July and December 2014, a total of 140 non-duplicate mono-microbial blood cultures were processed. An aliquot of positive blood culture broth was incubated with lysis buffer before the bacteria were filtered and washed. Micro-organisms recovered from the filter were first identified using VITEK MS and its suspension was used for direct AST by VITEK 2 once the ID was known. Direct ID and AST results were compared with classical methods using solid growth. Out of the 140 bottles tested, VITEK MS resulted in 70.7 % correct identification to the genus and/ or species level. For the 103 bottles where identification was possible, there was agreement in 97 samples (94.17 %) with classical culture. Compared to the routine method, the direct AST resulted in category agreement in 860 (96.5 %) of 891 bacteria-antimicrobial agent combinations tested. The results of direct ID and AST were available 16.1 hours before those of the standard approach on average. The combined use of VITEK MS and VITEK 2 directly on samples from positive blood culture bottles using a LFM technique can result in rapid and reliable ID and AST results in blood stream infections to result in early institution of targeted treatment. The combination of LFM and AST using VITEK 2 was found to expedite AST more reliably.

  17. Comparison of Zebrafish tmem88a mutant and morpholino knockdown phenotypes

    PubMed Central

    Place, Elsie S.; Smith, James C.

    2017-01-01

    Tmem88a is a transmembrane protein that is thought to be a negative regulator of the Wnt signalling pathway. Several groups have used antisense morpholino oligonucleotides in an effort to characterise the role of tmem88a in zebrafish cardiovascular development, but they have not obtained consistent results. Here, we generate an 8 bp deletion in the coding region of the tmem88a locus using TALENs, and we have gone on to establish a viable homozygous tmem88aΔ8 mutant line. Although tmem88aΔ8 mutants have reduced expression of some key haematopoietic genes, differentiation of erythrocytes and neutrophils is unaffected, contradicting our previous study using antisense morpholino oligonucleotides. We find that expression of the tmem88a paralogue tmem88b is not significantly changed in tmem88aΔ8 mutants and injection of the tmem88a splice-blocking morpholino oligonucleotide into tmem88aΔ8 mutants recapitulates the reduction of erythrocytes observed in morphants using o-Dianisidine. This suggests that there is a partial, but inessential, requirement for tmem88a during haematopoiesis and that morpholino injection exacerbates this phenotype in tmem88a morpholino knockdown embryos. PMID:28192479

  18. Redox sensitivity of the MyD88 immune signaling adapter.

    PubMed

    Stottmeier, Benjamin; Dick, Tobias P

    2016-12-01

    The transcription factor nuclear factor-κB (NF-κB) mediates expression of key genes involved in innate immunity and inflammation. NF-κB activation has been repeatedly reported to be modulated by hydrogen peroxide (H 2 O 2 ). Here, we show that the NF-κB-activating signaling adapter myeloid differentiation primary response gene 88 (MyD88) is highly sensitive to oxidation by H 2 O 2 and may be redox-regulated in its function, thus facilitating an influence of H 2 O 2 on the NF-κB signaling pathway. Upon oxidation, MyD88 forms distinct disulfide-linked conjugates which are reduced by the MyD88-interacting oxidoreductase nucleoredoxin (Nrx). MyD88 cysteine residues functionally modulate MyD88-dependent NF-κB activation, suggesting a link between MyD88 thiol oxidation state and immune signaling. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. 28 CFR 8.8 - Advertisement and declaration of forfeiture.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Advertisement and declaration of forfeiture. 8.8 Section 8.8 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.8 Advertisement and declaration of forfeiture. (a) The notice required by customs laws, section 607, Tariff Act of 1930, as amended ...

  20. 21 CFR 520.88d - Amoxicillin trihydrate soluble powder.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Amoxicillin trihydrate soluble powder. 520.88d Section 520.88d Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.88d Amoxicillin...

  1. 21 CFR 520.88d - Amoxicillin trihydrate soluble powder.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Amoxicillin trihydrate soluble powder. 520.88d Section 520.88d Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.88d Amoxicillin...

  2. 21 CFR 520.88d - Amoxicillin trihydrate soluble powder.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Amoxicillin trihydrate soluble powder. 520.88d Section 520.88d Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.88d Amoxicillin...

  3. CCDC88B is required for pathogenesis of inflammatory bowel disease.

    PubMed

    Fodil, Nassima; Moradin, Neda; Leung, Vicki; Olivier, Jean-Frederic; Radovanovic, Irena; Jeyakumar, Thiviya; Flores Molina, Manuel; McFarquhar, Ashley; Cayrol, Romain; Bozec, Dominique; Shoukry, Naglaa H; Kubo, Michiaki; Dimitrieva, Julia; Louis, Edouard; Theatre, Emilie; Dahan, Stephanie; Momozawa, Yukihide; Georges, Michel; Yeretssian, Garabet; Gros, Philippe

    2017-10-13

    Inflammatory bowel disease (IBD) involves interaction between host genetic factors and environmental triggers. CCDC88B maps within one IBD risk locus on human chromosome 11q13. Here we show that CCDC88B protein increases in the colon during intestinal injury, concomitant with an influx of CCDC88B + lymphoid and myeloid cells. Loss of Ccdc88b protects against DSS-induced colitis, with fewer pathological lesions and reduced intestinal inflammation in Ccdc88b-deficient mice. In a T cell transfer model of colitis, Ccdc88b mutant CD4 + T cells do not induce colitis in immunocompromised hosts. Expression of human CCDC88B RNA and protein is higher in IBD patient colons than in control colon tissue. In human CD14 + myeloid cells, CCDC88B is regulated by cis-acting variants. In a cohort of patients with Crohn's disease, CCDC88B expression correlates positively with disease risk. These findings suggest that CCDC88B has a critical function in colon inflammation and the pathogenesis of IBD.Hook-related protein family member CCDC88b is encoded by a locus that has been associated with inflammatory bowel disease. Here the authors show that Ccdc88b inactivation in T cells prevents colitis in a transfer model, and detect high colonic levels of CCDC88b in patients with Crohn disease or ulcerative colitis, identifying that expression correlates with disease risk.

  4. Inter- and intraobserver agreement in 24-hour combined multiple intraluminal impedance and pH measurement in children.

    PubMed

    Pilic, Denisa; Höfs, Carolin; Weitmann, Sandra; Nöh, Frank; Fröhlich, Thorsten; Skopnik, Heino; Köhler, Henrik; Wenzl, Tobias G; Schmidt-Choudhury, Anjona

    2011-09-01

    Assessment of intra- and interobserver agreement in multiple intraluminal impedance (MII) measurement between investigators from different institutions. Twenty-four 18- to 24-hour MII tracings were randomly chosen from 4 different institutions (6 per center). Software-aided automatic analysis was performed. Each result was validated by 2 independent investigators from the 4 different centers (4 investigator combinations). For intraobserver agreement, 6 measurements were analyzed twice by the same investigator. Agreement between investigators was calculated using the Cohen kappa coefficient. Interobserver agreement: 13 measurements showed a perfect agreement (kappa > 0.8); 9 had a substantial (kappa 0.61-0.8), 1 a moderate (kappa coefficient 0.41 to 0.6), and 1 a fair agreement (kappa coefficient 0.11-0.4). Median kappa value was 0.83. Intraobserver agreement: 5 tracings showed perfect and 1 showed a substantial agreement. The median kappa value was 0.88. Most measurements showed substantial to perfect intra- and interobserver agreement. Still, we found a few outliers presumably caused by poorer signal quality in some tracings rather than being observer dependent. An improvement of analysis results may be achieved by using a standard analysis protocol, a standardized method for judging tracing quality, better training options for method users, and more interaction between investigators from different institutions.

  5. Trends in surface-water quality in Connecticut, 1969-88

    USGS Publications Warehouse

    Trench, E.C.

    1996-01-01

    Surface-water-quality data from selected monitoring stations in Connecticut were analyzed for trend, using the Seasonal Kendall test, for water years 1969-88, 1975-88, and 1981-88. The number of constituents and stations evaluated varied with the different time periods. The 39 monitoring stations included 26 freshwater streams with associated discharge data, 7 tidally affected streams, 4 harbor stations, and 2 surface impoundments. Flow-adjustment procedures were used where possible to minimize the effects of stream- flow variability on trend results. The drainage area of the monitoring stations includes approximately 5,000 mi2 covering the State of Connecticut and about 11,000 mi2 in upstream drainage areas outside of the State. Drainage basin size for the freshwater streams ranges from 4.1 mi2 to 9,660 mi2. Land uses in the drainage basins range from undeveloped forested areas to highly urbanized metropolitan areas. During the period covered by the trend study, the State's population has grown, suburban development has increased, agricultural land use has decreased, and wastewater-treatment practices have improved. Increases in specific conductance and in the concentrations of calcium, magnesium, chloride, sulfate, dissolved solids, and total solids were geographically widespread and numerous during water years 1975-88 and indicate a general increase statewide in dissolved constituents in streamflow, both in urbanized and less developed areas. The effects of increasing urbanization, including municipal and industrial wastewater, septic system leachate, nonpoint runoff, and atmospheric deposition of contaminants, are possible causes for these increases. Decreases in turbidity and in the concentrations of total phosphorus, total organic carbon, and fecal coliform bacteria were geographically widespread and numerous during 1975-88. This general decrease in suspended material and bacteria may be attributable to basic improvements in the treatment of municipal and

  6. 38 CFR 4.88a - Chronic fatigue syndrome.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Chronic fatigue syndrome. 4.88a Section 4.88a Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS SCHEDULE FOR RATING DISABILITIES Disability Ratings Infectious Diseases, Immune Disorders and Nutritional...

  7. Evaluation of the Accelerate Pheno System for Fast Identification and Antimicrobial Susceptibility Testing from Positive Blood Cultures in Bloodstream Infections Caused by Gram-Negative Pathogens.

    PubMed

    Marschal, Matthias; Bachmaier, Johanna; Autenrieth, Ingo; Oberhettinger, Philipp; Willmann, Matthias; Peter, Silke

    2017-07-01

    Bloodstream infections (BSI) are an important cause of morbidity and mortality. Increasing rates of antimicrobial-resistant pathogens limit treatment options, prompting an empirical use of broad-range antibiotics. Fast and reliable diagnostic tools are needed to provide adequate therapy in a timely manner and to enable a de-escalation of treatment. The Accelerate Pheno system (Accelerate Diagnostics, USA) is a fully automated test system that performs both identification and antimicrobial susceptibility testing (AST) directly from positive blood cultures within approximately 7 h. In total, 115 episodes of BSI with Gram-negative bacteria were included in our study and compared to conventional culture-based methods. The Accelerate Pheno system correctly identified 88.7% (102 of 115) of all BSI episodes and 97.1% (102 of 105) of isolates that are covered by the system's identification panel. The Accelerate Pheno system generated an AST result for 91.3% (95 of 104) samples in which the Accelerate Pheno system identified a Gram-negative pathogen. The overall category agreement between the Accelerate Pheno system and culture-based AST was 96.4%, the rates for minor discrepancies 1.4%, major discrepancies 2.3%, and very major discrepancies 1.0%. Of note, ceftriaxone, piperacillin-tazobactam, and carbapenem resistance was correctly detected in blood culture specimens with extended-spectrum beta-lactamase-producing Escherichia coli ( n = 7) and multidrug-resistant Pseudomonas aeruginosa ( n = 3) strains. The utilization of the Accelerate Pheno system reduced the time to result for identification by 27.49 h ( P < 0.0001) and for AST by 40.39 h ( P < 0.0001) compared to culture-based methods in our laboratory setting. In conclusion, the Accelerate Pheno system provided fast, reliable results while significantly improving turnaround time in blood culture diagnostics of Gram-negative BSI. Copyright © 2017 American Society for Microbiology.

  8. 45 CFR 88.6 - Complaint handling and investigating.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 88.6 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION ENSURING THAT DEPARTMENT OF HEALTH AND HUMAN SERVICES FUNDS DO NOT SUPPORT COERCIVE OR DISCRIMINATORY POLICIES OR PRACTICES § 88.6 Complaint handling and investigating. The Office for Civil Rights (OCR) of the Department of...

  9. 45 CFR 88.2 - Complaint handling and investigating.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 88.2 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION ENSURING THAT DEPARTMENT OF HEALTH AND HUMAN SERVICES FUNDS DO NOT SUPPORT COERCIVE OR DISCIMINATORY POLICIES OR PRACTICES IN VIOLATION OF FEDERAL LAW § 88.2 Complaint handling and investigating. The Office for Civil Rights...

  10. 45 CFR 88.2 - Complaint handling and investigating.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 88.2 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION ENSURING THAT DEPARTMENT OF HEALTH AND HUMAN SERVICES FUNDS DO NOT SUPPORT COERCIVE OR DISCIMINATORY POLICIES OR PRACTICES IN VIOLATION OF FEDERAL LAW § 88.2 Complaint handling and investigating. The Office for Civil Rights...

  11. 45 CFR 88.2 - Complaint handling and investigating.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 88.2 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION ENSURING THAT DEPARTMENT OF HEALTH AND HUMAN SERVICES FUNDS DO NOT SUPPORT COERCIVE OR DISCIMINATORY POLICIES OR PRACTICES IN VIOLATION OF FEDERAL LAW § 88.2 Complaint handling and investigating. The Office for Civil Rights...

  12. 45 CFR 88.2 - Complaint handling and investigating.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 88.2 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION ENSURING THAT DEPARTMENT OF HEALTH AND HUMAN SERVICES FUNDS DO NOT SUPPORT COERCIVE OR DISCIMINATORY POLICIES OR PRACTICES IN VIOLATION OF FEDERAL LAW § 88.2 Complaint handling and investigating. The Office for Civil Rights...

  13. STS-88 Mission Specialist Currie suits up for launch

    NASA Technical Reports Server (NTRS)

    1998-01-01

    STS-88 Mission Specialist Nancy J. Currie dons her orange launch and entry suit in the Operations and Checkout Building. STS-88 will be Currie's third spaceflight. She and the five other STS-88 crew members will depart shortly for Launch Pad 39A where the Space Shuttle Endeavour is poised for liftoff on the first U.S. mission dedicated to the assembly of the International Space Station.

  14. Wound Healing Is Impaired in MyD88-Deficient Mice

    PubMed Central

    Macedo, Lisa; Pinhal-Enfield, Grace; Alshits, Vera; Elson, Genie; Cronstein, Bruce Neil; Leibovich, Samuel Joseph

    2007-01-01

    Synergy between Toll-like receptor (TLR) and adenosine A2A receptor (A2AR) signaling switches macrophages from production of inflammatory cytokines such as tumor necrosis factor-α to production of the angiogenic growth factor vascular endothelial growth factor (VEGF). We show in this study that this switch critically requires signaling through MyD88, IRAK4, and TRAF6. Macrophages from mice lacking MyD88 (MyD88−/−) or IRAK4 (IRAK4−/−) lacked responsiveness to TLR agonists and did not respond to A2AR agonists by expressing VEGF. Suppression of TRAF6 expression with siRNA in RAW264.7 macrophages also blocked their response to TLR and A2AR agonists. Excisional skin wounds in MyD88−/− mice healed at a markedly slower rate than wounds in wild-type MyD88+/+ mice, showing delayed contraction, decreased and delayed granulation tissue formation, and reduced new blood vessel density. Although macrophages accumulated to higher levels in MyD88−/− wounds than in controls, expression of VEGF and HIF1-α mRNAs was elevated in MyD88+/+ wounds. CGS21680, an A2AR agonist, promoted repair in MyD88+/+ wounds and stimulated angiogenesis but had no significant effect on healing of MyD88−/− wounds. These results suggest that the synergistic interaction between TLR and A2AR signaling observed in vitro that switches macrophages from an inflammatory to an angiogenic phenotype also plays a role in wound healing in vivo. PMID:17974599

  15. 21 CFR 520.88e - Amoxicillin trihydrate boluses.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 520.88e Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.88e Amoxicillin...) Limitations. For oral use in preruminating calves including veal calves only, not for use in other animals...

  16. 21 CFR 520.88e - Amoxicillin trihydrate boluses.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 520.88e Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.88e Amoxicillin...) Limitations. For oral use in preruminating calves including veal calves only, not for use in other animals...

  17. 21 CFR 520.88e - Amoxicillin trihydrate boluses.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 520.88e Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.88e Amoxicillin...) Limitations. For oral use in preruminating calves including veal calves only, not for use in other animals...

  18. 21 CFR 312.88 - Safeguards for patient safety.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... initial human testing (§ 312.23), and the monitoring of adverse drug experiences through the requirements... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Safeguards for patient safety. 312.88 Section 312.88 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

  19. 21 CFR 312.88 - Safeguards for patient safety.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... initial human testing (§ 312.23), and the monitoring of adverse drug experiences through the requirements... 21 Food and Drugs 5 2013-04-01 2013-04-01 false Safeguards for patient safety. 312.88 Section 312.88 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

  20. 21 CFR 312.88 - Safeguards for patient safety.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... initial human testing (§ 312.23), and the monitoring of adverse drug experiences through the requirements... 21 Food and Drugs 5 2011-04-01 2011-04-01 false Safeguards for patient safety. 312.88 Section 312.88 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

  1. 21 CFR 312.88 - Safeguards for patient safety.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... initial human testing (§ 312.23), and the monitoring of adverse drug experiences through the requirements... 21 Food and Drugs 5 2014-04-01 2014-04-01 false Safeguards for patient safety. 312.88 Section 312.88 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

  2. 21 CFR 312.88 - Safeguards for patient safety.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... initial human testing (§ 312.23), and the monitoring of adverse drug experiences through the requirements... 21 Food and Drugs 5 2012-04-01 2012-04-01 false Safeguards for patient safety. 312.88 Section 312.88 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

  3. Inter-Observer Agreement of Whole-Body Computed Tomography in Staging and Response Assessment in Lymphoma: The Lugano Classification.

    PubMed

    Razek, Ahmed Abdel Khalek Abdel; Shamaa, Sameh; Lattif, Mahmoud Abdel; Yousef, Hanan Hamid

    2017-01-01

    To assess inter-observer agreement of whole-body computed tomography (WBCT) in staging and response assessment in lymphoma according to the Lugano classification. Retrospective analysis was conducted of 115 consecutive patients with lymphomas (45 females, 70 males; mean age of 46 years). Patients underwent WBCT with a 64 multi-detector CT device for staging and response assessment after a complete course of chemotherapy. Image analysis was performed by 2 reviewers according to the Lugano classification for staging and response assessment. The overall inter-observer agreement of WBCT in staging of lymphoma was excellent ( k =0.90, percent agreement=94.9%). There was an excellent inter-observer agreement for stage I ( k =0.93, percent agreement=96.4%), stage II ( k =0.90, percent agreement=94.8%), stage III ( k =0.89, percent agreement=94.6%) and stage IV ( k =0.88, percent agreement=94%). The overall inter-observer agreement in response assessment after a completer course of treatment was excellent ( k =0.91, percent agreement=95.8%). There was an excellent inter-observer agreement in progressive disease ( k =0.94, percent agreement=97.1%), stable disease ( k =0.90, percent agreement=95%), partial response ( k =0.96, percent agreement=98.1%) and complete response ( k =0.87, Percent agreement=93.3%). We concluded that WBCT is a reliable and reproducible imaging modality for staging and treatment assessment in lymphoma according to the Lugano classification.

  4. STS-88 in-flight crew portrait

    NASA Image and Video Library

    1998-12-14

    S88-E-5169 (12-14-98) --- A pre-set electronic still camera (ESC) was used to take one of the traditional in-flight crew portraits for the STS-88 members on Endeavour's mid deck. From the left are Jerry L. Ross, James H. Newman, Robert D. Cabana, Frederick W. (Rick) Sturckow, Nancy J. Currie and Sergei K. Krikalev. Krikalev, representing the Russian Space Agency (RSA), has been assigned as one of the crew members for the first ISS crew. A banner representing the participating countries for ISS and a model of the connected Unity-Zarya modules are in the background. The photo was taken at 23:41:40, Dec. 14.

  5. Recipient Myd88 Deficiency Promotes Spontaneous Resolution of Kidney Allograft Rejection

    PubMed Central

    Lerret, Nadine M.; Li, Ting; Wang, Jiao-Jing; Kang, Hee-Kap; Wang, Sheng; Wang, Xueqiong; Jie, Chunfa; Kanwar, Yashpal S.; Abecassis, Michael M.

    2015-01-01

    The myeloid differentiation protein 88 (MyD88) adapter protein is an important mediator of kidney allograft rejection, yet the precise role of MyD88 signaling in directing the host immune response toward the development of kidney allograft rejection remains unclear. Using a stringent mouse model of allogeneic kidney transplantation, we demonstrated that acute allograft rejection occurred equally in MyD88-sufficient (wild-type [WT]) and MyD88−/− recipients. However, MyD88 deficiency resulted in spontaneous diminution of graft infiltrating effector cells, including CD11b−Gr-1+ cells and activated CD8 T cells, as well as subsequent restoration of near-normal renal graft function, leading to long-term kidney allograft acceptance. Compared with T cells from WT recipients, T cells from MyD88−/− recipients failed to mount a robust recall response upon donor antigen restimulation in mixed lymphocyte cultures ex vivo. Notably, exogenous IL-6 restored the proliferation rate of T cells, particularly CD8 T cells, from MyD88−/− recipients to the proliferation rate of cells from WT recipients. Furthermore, MyD88−/− T cells exhibited diminished expression of chemokine receptors, specifically CCR4 and CXCR3, and the impaired ability to accumulate in the kidney allografts despite an otherwise MyD88-sufficient environment. These results provide a mechanism linking the lack of intrinsic MyD88 signaling in T cells to the effective control of the rejection response that results in spontaneous resolution of acute rejection and long-term graft protection. PMID:25788530

  6. STS-88 Mission Insignia

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Designed by the STS-88 crew members, this patch commemorates the first assembly flight to carry United States-built hardware for constructing the International Space Station (ISS). This flight's primary task was to assemble the cornerstone of the Space Station: the Node with the Functional Cargo Block (FGB). The rising sun symbolizes the dawning of a new era of international cooperation in space and the beginning of a new program: the International Space Station. The Earth scene outlines the countries of the Station Partners: the United States, Russia, those of the European Space Agency (ESA), Japan, and Canada. Along with the Pressurized Mating Adapters (PMA) and the Functional Cargo Block, the Node is shown in the final mated configuration while berthed to the Space Shuttle during the STS-88/2A mission. The Big Dipper Constellation points the way to the North Star, a guiding light for pioneers and explorers for generations. In the words of the crew, These stars symbolize the efforts of everyone, including all the countries involved in the design and construction of the International Space Station, guiding us into the future.

  7. 12 CFR 133.5 - Related agreements considered a single agreement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... agreement. 133.5 Section 133.5 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY DISCLOSURE AND REPORTING OF CRA-RELATED AGREEMENTS § 133.5 Related agreements considered a single agreement... § 133.2 of this part. (a) Agreements entered into by same parties. All written agreements to which an...

  8. 40 CFR 600.113-88 - Fuel economy calculations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Fuel economy calculations. 600.113-88 Section 600.113-88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1978 and Later Model Year Automobiles-Test...

  9. 33 CFR 88.15 - Lights on dredge pipelines.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lights on dredge pipelines. 88.15... NAVIGATION RULES ANNEX V: PILOT RULES § 88.15 Lights on dredge pipelines. Dredge pipelines that are floating or supported on trestles shall display the following lights at night and in periods of restricted...

  10. 33 CFR 88.15 - Lights on dredge pipelines.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Lights on dredge pipelines. 88.15... NAVIGATION RULES ANNEX V: PILOT RULES § 88.15 Lights on dredge pipelines. Dredge pipelines that are floating or supported on trestles shall display the following lights at night and in periods of restricted...

  11. 33 CFR 88.15 - Lights on dredge pipelines.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Lights on dredge pipelines. 88.15... NAVIGATION RULES ANNEX V: PILOT RULES § 88.15 Lights on dredge pipelines. Dredge pipelines that are floating or supported on trestles shall display the following lights at night and in periods of restricted...

  12. 33 CFR 88.15 - Lights on dredge pipelines.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Lights on dredge pipelines. 88.15... NAVIGATION RULES ANNEX V: PILOT RULES § 88.15 Lights on dredge pipelines. Dredge pipelines that are floating or supported on trestles shall display the following lights at night and in periods of restricted...

  13. 33 CFR 88.15 - Lights on dredge pipelines.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Lights on dredge pipelines. 88.15... NAVIGATION RULES ANNEX V: PILOT RULES § 88.15 Lights on dredge pipelines. Dredge pipelines that are floating or supported on trestles shall display the following lights at night and in periods of restricted...

  14. Changes in mortality in Pakistan 1960-88.

    PubMed

    Sathar, Z A

    1991-01-01

    General trends in Pakistan infant/child mortality, adult mortality, differentials in mortality, and prospects for future declines in mortality are presented. Future mortality declines are desired and recognized by government policy. Paucity of data and quality control issues cloud an accurate presentation of trends. The crude death rate (CDR) has nonetheless declined in 4 decades form 40-50/1000 in 1900 to 10-12/1000 in the late 1970s and early 1980s. The 1984-88 Pakistan Demographic Survey (PDS) reports a CDR of 10.8/1000. Life expectancy is expected to improve. The majority of deaths are infant/child related. Government policy aims to have 1 trained traditional birth attendant/village in order to improve maternal and child care. Although official statistics are in dispute, there is general agreement that infant mortality has declined particularly in neonatal mortality, i.e., infant mortality is now at 56-62/1000 and neonatal mortality 48/1000 in 1988. Data are derived from the Pakistan Fertility Survey (PFS), and Population Labor Force and Migration Survey (PLM) in the 1960-70s, the 1976-79 Population Growth Surveys (PGS), and the 1984-88 PDS. Lower death rates have also occurred among adults. Sex differentials in mortality have reversed, although the sex ratio still favors males; the improvement may be due to better reporting of female mortality. Life expectancy has improved for women, and there are gains over males. The disadvantage at 15-40 years has been eliminated. Differential mortality is expressed geographically, where urban mortality is much lower than in rural areas. There is a relationship between mothers who have some education and lower infant mortality. Labor force participation effects on mortality are dependent on the reasons for work: economic necessity or in pursuance of a career and supplemental income. Findings on the relationship between income or social class and mortality are equivocal. Improvements are dependent on further fertility

  15. 33 CFR 88.13 - Lights on moored barges.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lights on moored barges. 88.13... NAVIGATION RULES ANNEX V: PILOT RULES § 88.13 Lights on moored barges. (a) The following barges shall display at night and if practicable in periods of restricted visibility the lights described in paragraph (b...

  16. 33 CFR 88.13 - Lights on moored barges.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Lights on moored barges. 88.13... NAVIGATION RULES ANNEX V: PILOT RULES § 88.13 Lights on moored barges. (a) The following barges shall display at night and if practicable in periods of restricted visibility the lights described in paragraph (b...

  17. 33 CFR 88.13 - Lights on moored barges.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Lights on moored barges. 88.13... NAVIGATION RULES ANNEX V: PILOT RULES § 88.13 Lights on moored barges. (a) The following barges shall display at night and if practicable in periods of restricted visibility the lights described in paragraph (b...

  18. 33 CFR 88.13 - Lights on moored barges.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Lights on moored barges. 88.13... NAVIGATION RULES ANNEX V: PILOT RULES § 88.13 Lights on moored barges. (a) The following barges shall display at night and if practicable in periods of restricted visibility the lights described in paragraph (b...

  19. 33 CFR 88.13 - Lights on moored barges.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Lights on moored barges. 88.13... NAVIGATION RULES ANNEX V: PILOT RULES § 88.13 Lights on moored barges. (a) The following barges shall display at night and if practicable in periods of restricted visibility the lights described in paragraph (b...

  20. 42 CFR 430.88 - Evidence.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS GRANTS TO STATES FOR MEDICAL ASSISTANCE PROGRAMS Hearings on Conformity of State Medicaid Plans and Practice to Federal Requirements § 430.88 Evidence. (a) Evidentiary purpose. The hearing is...

  1. STS-88 in-flight crew portrait

    NASA Image and Video Library

    1998-12-14

    S88-E-5170 (12-15-98) --- A pre-set electronic still camera (ESC) was used to take one of the traditional in-flight crew portraits for the STS-88 members on Endeavour's mid deck. From the left are Frederick W. (Rick) Sturckow, Jerry L. Ross, James H. Newman, Nancy J. Currie, Robert D. Cabana and Sergei K. Krikalev. Krikalev, representing the Russian Space Agency (RSA), has been assigned as one of the crew members for the first ISS crew. A banner representing the participating countries for ISS and a model (near Krikalev) of the connected Unity-Zarya modules are in the background. The photo was taken at 00:12:48 GMT, Dec. 15.

  2. 40 CFR Appendix - Tables to Subpart B of Part 88

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Tables to Subpart B of Part 88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES California Pilot Test Program State opt-in for the California Pilot Test Program. Pt. 88, Subpt. B, Tables Tables to Subpart B of Part 88...

  3. 40 CFR Appendix - Tables to Subpart B of Part 88

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Tables to Subpart B of Part 88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES California Pilot Test Program State opt-in for the California Pilot Test Program. Pt. 88, Subpt. B, Tables Tables to Subpart B of Part 88...

  4. 40 CFR Appendix - Tables to Subpart B of Part 88

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Tables to Subpart B of Part 88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES California Pilot Test Program State opt-in for the California Pilot Test Program. Pt. 88, Subpt. B, Tables Tables to Subpart B of Part 88 Tabl...

  5. 40 CFR Appendix - Tables to Subpart B of Part 88

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Tables to Subpart B of Part 88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES California Pilot Test Program State opt-in for the California Pilot Test Program. Pt. 88, Subpart B, Tables Tables to Subpart B of Part 88...

  6. 40 CFR Appendix - Tables to Subpart B of Part 88

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Tables to Subpart B of Part 88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES California Pilot Test Program State opt-in for the California Pilot Test Program. Pt. 88, Subpart B, Tables Tables to Subpart B of Part 88...

  7. 42 CFR 88.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... RELATED ACTIVITIES WORLD TRADE CENTER HEALTH PROGRAM § 88.1 Definitions. Act means the Title XXXIII of the..., or a WTC-related health condition or a health condition medically associated with a WTC-related... medicine, environmental medicine, trauma-related psychiatry and psychology, and social services counseling...

  8. 42 CFR 88.1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... RELATED ACTIVITIES WORLD TRADE CENTER HEALTH PROGRAM § 88.1 Definitions. Act means the Title XXXIII of the..., or a WTC-related health condition or a health condition medically associated with a WTC-related... medicine, environmental medicine, trauma-related psychiatry and psychology, and social services counseling...

  9. Community Science and Data Center (CSDC) | ast.noao.edu

    Science.gov Websites

    ground-based nighttime astronomy in the United States and is operated by the Association of Universities for Research in Astronomy (AURA). under cooperative agreement with the National Science Foundation. If you would like information about solar astronomy, visit the National Solar Observatory. If you would

  10. 42 CFR 88.1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... RELATED ACTIVITIES WORLD TRADE CENTER HEALTH PROGRAM § 88.1 Definitions. Link to an amendment published at... screening-eligible survivor as eligible for monitoring and treatment, or a WTC-related health condition or a health condition medically associated with a WTC-related health condition in a particular WTC responder...

  11. Good Agreement Between Transabdominal and Endoscopic Ultrasound of the Pancreas in Chronic Pancreatitis.

    PubMed

    Engjom, Trond; Pham, Khahn Do-Chong; Erchinger, Friedemann; Haldorsen, Ingfrid Salvesen; Gilja, Odd Helge; Dimcevski, Georg; Havre, Roald Flesland

    2018-03-26

     We aimed to evaluate the agreement of single criteria and dedicated scores from transabdominal ultrasound of the pancreas (US) compared to standards by endoscopic ultrasound (EUS) and computed tomography (CT).  In this observational cohort study performed in a tertiary care center, US and EUS were performed in 110 patients referred for suspected CP. Based on the Mayo score, 52 patients were diagnosed with CP. The sonographic findings obtained by both methods were registered. The number of criteria was counted and scored according to the Rosemont score.  Agreement between the number of detected US and EUS criteria was substantial (ICC = 0.74 [0.61 - 0.83]. Adding Rosemont weighting improved the agreement (ICC = 0.88 [0.81 - 0.92]). Regarding individual criteria, the agreement was substantial for the detection of calcifications (κ = 0.86) and moderate for cysts and irregular or dilated pancreatic duct (κ = 0.42 - 0.58). Agreement for the other criteria was poorer (κ≤ 0.40). The diagnostic performance indices [95 % CI] of US for diagnosing CP (using Mayo score as reference standard) were for the unweighted score: Sensitivity: 0.65 [0.51 - 0.78], specificity: 0.97 [0.87 - 1.00]; and for Rosemont score: Sensitivity: 0.75 [0.61 - 0.86], specificity: 0.95 [0.83 - 0.99].  The agreement between US and EUS for the unweighted and weighted scores was substantial. For the features calcifications, cysts and main pancreatic duct (MPD) changes, agreement was moderate to substantial. For the other detected US criteria, the agreement with EUS was too poor to be clinically relevant. © Georg Thieme Verlag KG Stuttgart · New York.

  12. Reliability of the modified Gross Motor Function Measure-88 (GMFM-88) for children with both Spastic Cerebral Palsy and Cerebral Visual Impairment: A preliminary study.

    PubMed

    Salavati, M; Krijnen, W P; Rameckers, E A A; Looijestijn, P L; Maathuis, C G B; van der Schans, C P; Steenbergen, B

    2015-01-01

    The aims of this study were to adapt the Gross Motor Function Measure-88 (GMFM-88) for children with Cerebral Palsy (CP) and Cerebral Visual Impairment (CVI) and to determine the test-retest and interobserver reliability of the adapted version. Sixteen paediatric physical therapists familiar with CVI participated in the adaptation process. The Delphi method was used to gain consensus among a panel of experts. Seventy-seven children with CP and CVI (44 boys and 33 girls, aged between 50 and 144 months) participated in this study. To assess test-retest and interobserver reliability, the GMFM-88 was administered twice within three weeks (Mean=9 days, SD=6 days) by trained paediatric physical therapists, one of whom was familiar with the child and one who wasn't. Percentages of identical scores, Cronbach's alphas and intraclass correlation coefficients (ICC) were computed for each dimension level. All experts agreed on the proposed adaptations of the GMFM-88 for children with CP and CVI. Test-retest reliability ICCs for dimension scores were between 0.94 and 1.00, mean percentages of identical scores between 29 and 71, and interobserver reliability ICCs of the adapted GMFM-88 were 0.99-1.00 for dimension scores. Mean percentages of identical scores varied between 53 and 91. Test-retest and interobserver reliability of the GMFM-88-CVI for children with CP and CVI was excellent. Internal consistency of dimension scores lay between 0.97 and 1.00. The psychometric properties of the adapted GMFM-88 for children with CP and CVI are reliable and comparable to the original GMFM-88. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Evaluation of the VITEK 2 System for Identification and Antimicrobial Susceptibility Testing of Medically Relevant Gram-Positive Cocci

    PubMed Central

    Ligozzi, Marco; Bernini, Cinzia; Bonora, Maria Grazia; de Fatima, Maria; Zuliani, Jessica; Fontana, Roberta

    2002-01-01

    A study was conducted to evaluate the new VITEK 2 system (bioMérieux) for identification and antibiotic susceptibility testing of gram-positive cocci. Clinical isolates of Staphylococcus aureus (n = 100), coagulase-negative staphylococci (CNS) (n = 100), Enterococcus spp. (n = 89), Streptococcus agalactiae (n = 29), and Streptococcus pneumoniae (n = 66) were examined with the ID-GPC identification card and with the AST-P515 (for staphylococci), AST-P516 (for enterococci and S. agalactiae) and AST-P506 (for pneumococci) susceptibility cards. The identification comparison methods were the API Staph for staphylococci and the API 20 Strep for streptococci and enterococci; for antimicrobial susceptibility testing, the agar dilution method according to the procedure of the National Committee for Clinical Laboratory Standards (NCCLS) was used. The VITEK 2 system correctly identified to the species level (only one choice or after simple supplementary tests) 99% of S. aureus, 96.5% of S. agalactiae, 96.9% of S. pneumoniae, 92.7% of Enterococcus faecalis, 91.3% of Staphylococcus haemolyticus, and 88% of Staphylococcus epidermidis but was least able to identify Enterococcus faecium (71.4% correct). More than 90% of gram-positive cocci were identified within 3 h. According to the NCCLS breakpoints, antimicrobial susceptibility testing with the VITEK 2 system gave 96% correct category agreement, 0.82% very major errors, 0.17% major errors, and 2.7% minor errors. Antimicrobial susceptibility testing showed category agreement from 94 to 100% for S. aureus, from 90 to 100% for CNS, from 91 to 100% for enterococci, from 96 to 100% for S. agalactiae, and from 91 to 100% for S. pneumoniae. Microorganism-antibiotic combinations that gave very major errors were CNS-erythromycin, CNS-oxacillin, enterococci-teicoplanin, and enterococci-high-concentration gentamicin. Major errors were observed for CNS-oxacillin and S. agalactiae-tetracycline combinations. In conclusion the results of

  14. 45 CFR 88.3 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Community Mental Health Centers Act, or the Developmental Disabilities Assistance and Bill of Rights Act of... DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION ENSURING THAT DEPARTMENT OF HEALTH AND HUMAN...) The Department of Health and Human Services is required to comply with sections §§ 88.4(a), (b)(1...

  15. 45 CFR 88.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION ENSURING THAT DEPARTMENT OF HEALTH AND HUMAN SERVICES FUNDS DO NOT SUPPORT COERCIVE OR DISCRIMINATORY POLICIES OR PRACTICES § 88.1 Purpose. The purpose of this Part is to provide for the implementation and enforcement of the Church Amendments, 42 U.S.C...

  16. 31 CFR 306.88 - Political entities and public corporations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... corporations. 306.88 Section 306.88 Money and Finance: Treasury Regulations Relating to Money and Finance... entities and public corporations. Securities registered in the name of, or assigned to, a State, county, city, town, village, school district or other political entity, public body or corporation, may be...

  17. 31 CFR 306.88 - Political entities and public corporations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... corporations. 306.88 Section 306.88 Money and Finance: Treasury Regulations Relating to Money and Finance... entities and public corporations. Securities registered in the name of, or assigned to, a State, county, city, town, village, school district or other political entity, public body or corporation, may be...

  18. 31 CFR 306.88 - Political entities and public corporations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... corporations. 306.88 Section 306.88 Money and Finance: Treasury Regulations Relating to Money and Finance... entities and public corporations. Securities registered in the name of, or assigned to, a State, county, city, town, village, school district or other political entity, public body or corporation, may be...

  19. Expression of Mucin-Type Glycoprotein K88 Receptors Strongly Correlates with Piglet Susceptibility to K88+ Enterotoxigenic Escherichia coli, but Adhesion of This Bacterium to Brush Borders Does Not

    PubMed Central

    Francis, David H.; Grange, Philippe A.; Zeman, David H.; Baker, Diane R.; Sun, Ronggai; Erickson, Alan K.

    1998-01-01

    Three antigenic variants of the K88 fimbrial adhesin exist in nature, K88ab, K88ac, and K88ad. Enterotoxigenic Escherichia coli (ETEC) strains that produce these fimbriae cause life-threatening diarrhea in some but not all young pigs. The susceptibility of pigs to these organisms has been correlated with the adherence of bacteria to isolated enterocyte brush borders. Whether that correlation holds for multiple K88 variants and over a broad genetic base of pigs is unknown and was the impetus for this study. We also desired to examine the correlation of the expression of a porcine intestinal brush border mucin-type glycoprotein (IMTGP) which binds K88ab and K88ac with the susceptibility of piglets to K88+ ETEC. Of 31 neonatal gnotobiotic pigs inoculated with K88ab+ or K88ac+ ETEC, 13 developed severe diarrhea, became dehydrated, and died or became moribund. Another pig became severely lethargic but not dehydrated. In vitro brush border adherence analysis was not possible for 10 of the severely ill pigs due to colonization by challenge strains. However, of the 17 pigs that did not become severely ill, 8 (47%) had brush borders that supported the adherence of K88ab+ and K88ac+ bacteria in vitro, suggesting a poor correlation between in vitro brush border adherence and piglet susceptibility to K88+ ETEC. By contrast, the expression of IMTGP was highly correlated with susceptibility to K88+ ETEC. Of the 12 pigs that produced IMTGP, 11 developed severe diarrhea. The other pig that produced IMTGP became lethargic but not severely diarrheic. Only 2 of 18 pigs that did not produce IMTGP became severely diarrheic. Colonizing bacteria were observed in histologic sections of intestines from all pigs that expressed IMTGP except for the one that did not develop severe diarrhea. However, colonizing bacteria were observed in histologic sections from only one pig that did not produce IMTGP. The bacterial concentration in the jejuna and ilea of pigs expressing IMTGP was significantly

  20. Agreement in electrocardiogram interpretation in patients with septic shock.

    PubMed

    Mehta, Sangeeta; Granton, John; Lapinsky, Stephen E; Newton, Gary; Bandayrel, Kristofer; Little, Anjuli; Siau, Chuin; Cook, Deborah J; Ayers, Dieter; Singer, Joel; Lee, Terry C; Walley, Keith R; Storms, Michelle; Cooper, Jamie; Holmes, Cheryl L; Hebert, Paul; Gordon, Anthony C; Presneill, Jeff; Russell, James A

    2011-09-01

    The reliability of electrocardiogram interpretation to diagnose myocardial ischemia in critically ill patients is unclear. In adults with septic shock, we assessed intra- and inter-rater agreement of electrocardiogram interpretation, and the effect of knowledge of troponin values on these interpretations. Prospective substudy of a randomized trial of vasopressin vs. norepinephrine in septic shock. Nine Canadian intensive care units. Adults with septic shock requiring at least 5 μg/min of norepinephrine for 6 hrs. Twelve-lead electrocardiograms were recorded before study drug, and 6 hrs, 2 days, and 4 days after study drug initiation. Two physician readers, blinded to patient data and group, independently interpreted electrocardiograms on three occasions (first two readings were blinded to patient data; third reading was unblinded to troponin). To calibrate and refine definitions, both readers initially reviewed 25 trial electrocardiograms representing normal to abnormal. Cohen's Kappa and the φ statistic were used to analyze intra- and inter-rater agreement. One hundred twenty-one patients (62.2 ± 16.5 yrs, Acute Physiology and Chronic Health Evaluation II 28.6 ± 7.7) had 373 electrocardiograms. Blinded to troponin, readers 1 and 2 interpreted 46.4% and 30.0% of electrocardiograms as normal, and 15.3% and 12.3% as ischemic, respectively. Intrarater agreement was moderate for overall ischemia (κ 0.54 and 0.58), moderate/good for "normal" (κ 0.69 and 0.55), fair to good for specific signs of ischemia (ST elevation, T inversion, and Q waves, reader 1 κ 0.40 to 0.69; reader 2 κ 0.56 to 0.70); and good/very good for atrial arrhythmias (κ 0.84 and 0.79) and bundle branch block (κ 0.88 and 0.79). Inter-rater agreement was fair for ischemia (κ 0.29), moderate for ST elevation (κ 0.48), T inversion (κ 0.52), and Q waves (κ 0.44), good for bundle branch block (κ 0.78), and very good for atrial arrhythmias (κ 0.83). Inter-rater agreement for ischemia improved

  1. Remodeling of Sensorimotor Brain Connectivity in Gpr88-Deficient Mice.

    PubMed

    Arefin, Tanzil Mahmud; Mechling, Anna E; Meirsman, Aura Carole; Bienert, Thomas; Hübner, Neele Saskia; Lee, Hsu-Lei; Ben Hamida, Sami; Ehrlich, Aliza; Roquet, Dan; Hennig, Jürgen; von Elverfeldt, Dominik; Kieffer, Brigitte Lina; Harsan, Laura-Adela

    2017-10-01

    Recent studies have demonstrated that orchestrated gene activity and expression support synchronous activity of brain networks. However, there is a paucity of information on the consequences of single gene function on overall brain functional organization and connectivity and how this translates at the behavioral level. In this study, we combined mouse mutagenesis with functional and structural magnetic resonance imaging (MRI) to determine whether targeted inactivation of a single gene would modify whole-brain connectivity in live animals. The targeted gene encodes GPR88 (G protein-coupled receptor 88), an orphan G protein-coupled receptor enriched in the striatum and previously linked to behavioral traits relevant to neuropsychiatric disorders. Connectivity analysis of Gpr88-deficient mice revealed extensive remodeling of intracortical and cortico-subcortical networks. Most prominent modifications were observed at the level of retrosplenial cortex connectivity, central to the default mode network (DMN) whose alteration is considered a hallmark of many psychiatric conditions. Next, somatosensory and motor cortical networks were most affected. These modifications directly relate to sensorimotor gating deficiency reported in mutant animals and also likely underlie their hyperactivity phenotype. Finally, we identified alterations within hippocampal and dorsal striatum functional connectivity, most relevant to a specific learning deficit that we previously reported in Gpr88 -/- animals. In addition, amygdala connectivity with cortex and striatum was weakened, perhaps underlying the risk-taking behavior of these animals. This is the first evidence demonstrating that GPR88 activity shapes the mouse brain functional and structural connectome. The concordance between connectivity alterations and behavior deficits observed in Gpr88-deficient mice suggests a role for GPR88 in brain communication.

  2. Adjuvant heparanase inhibitor PI-88 therapy for hepatocellular carcinoma recurrence

    PubMed Central

    Liu, Chun-Jen; Chang, Juliana; Lee, Po-Huang; Lin, Deng-Yn; Wu, Cheng-Chung; Jeng, Long-Bin; Lin, Yih-Jyh; Mok, King-Tong; Lee, Wei-Chen; Yeh, Hong-Zen; Ho, Ming-Chih; Yang, Sheng-Shun; Yang, Mei-Due; Yu, Ming-Chin; Hu, Rey-Heng; Peng, Cheng-Yuan; Lai, Kuan-Lang; Chang, Stanley Shi-Chung; Chen, Pei-Jer

    2014-01-01

    AIM: To demonstrate that administering heparanase inhibitor PI-88 at 160 mg/d is safe and promising in reducing hepatocellular carcinoma (HCC) recurrence for up to 3 year following curative resection. METHODS: A total of 143 patients (83.1% of the 172 participants in the phase II study) participated in the follow-up study. Of these patients, 50 had received no treatment, 48 had received 160 mg/d PI-88, and 45 had received 250 mg/d PI-88 during the phase II trial. Safety parameters and the following efficacy endpoints were investigated: (1) time to recurrence; (2) disease-free survival; and (3) overall survival. RESULTS: PI-88 at 160 mg/d delayed the onset and frequency of HCC recurrence, and provided a clinically significant survival advantage for up to 3 years after treatment compared with those of the control group: (1) the recurrence-free rate increased from 50% to 63%, and (2) time to recurrence at the 36th percentile was postponed by 78%. The efficacy of administering PI-88 at 250 mg/d was confounded by a high dropout rate (11 out of 54 patients). Additionally, subgroup analyses of patients with (1) multiple tumors or a single tumor ≥ 2 cm; and (2) hepatitis B or C revealed that administering PI-88 at 160 mg/d conferred the most significant survival advantage (56.8% improvement in disease-free survival, P = 0.045) for patients with both risk factors for recurrence. CONCLUSION: Administering PI-88 at 160 mg/d is a safe and well-tolerated dosage that may confer significant clinical benefits for patients with HCC. PMID:25170226

  3. 29 CFR 37.88 - Who may contact CRC about a complaint?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Who may contact CRC about a complaint? 37.88 Section 37.88... PROVISIONS OF THE WORKFORCE INVESTMENT ACT OF 1998 (WIA) Compliance Procedures § 37.88 Who may contact CRC... contact CRC for information about the complaint. The Director will determine what information, if any...

  4. 28 CFR 8.8 - Advertisement and declaration of forfeiture.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... forfeiture. 8.8 Section 8.8 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR... (FBI) within 20 days from the date of the first publication of the notice a claim to such property and... judicial district in which the property was seized. If a claim is not made within the time period, the FBI...

  5. 28 CFR 8.8 - Advertisement and declaration of forfeiture.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... forfeiture. 8.8 Section 8.8 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR... (FBI) within 20 days from the date of the first publication of the notice a claim to such property and... judicial district in which the property was seized. If a claim is not made within the time period, the FBI...

  6. 21 CFR 520.88c - Amoxicillin trihydrate oral suspension.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Amoxicillin trihydrate oral suspension. 520.88c Section 520.88c Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... orally, twice a day using a dosing pump. (2) Indications for use. Treatment of baby pigs under 10 pounds...

  7. 21 CFR 520.88c - Amoxicillin trihydrate oral suspension.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Amoxicillin trihydrate oral suspension. 520.88c Section 520.88c Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... orally, twice a day using a dosing pump. (2) Indications for use. Treatment of baby pigs under 10 pounds...

  8. 21 CFR 520.88c - Amoxicillin trihydrate oral suspension.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 6 2012-04-01 2012-04-01 false Amoxicillin trihydrate oral suspension. 520.88c Section 520.88c Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... orally, twice a day using a dosing pump. (2) Indications for use. Treatment of baby pigs under 10 pounds...

  9. 21 CFR 520.88c - Amoxicillin trihydrate oral suspension.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Amoxicillin trihydrate oral suspension. 520.88c Section 520.88c Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... orally, twice a day using a dosing pump. (2) Indications for use. Treatment of baby pigs under 10 pounds...

  10. 21 CFR 520.88c - Amoxicillin trihydrate oral suspension.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Amoxicillin trihydrate oral suspension. 520.88c Section 520.88c Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... orally, twice a day using a dosing pump. (2) Indications for use. Treatment of baby pigs under 10 pounds...

  11. Astéroides et satellites de Saturne: quelques résultats récents et contribution éventuelle des données Hipparcos.

    NASA Astrophysics Data System (ADS)

    Viateau, B.; Rapaport, M.

    48 astéroides et 2 satellites de Saturne étaient au programme de la mission Hipparcos, et diverses propositions ont été faites pour l'utilisation de ces données. Les auteurs présentent quelques résultats récents concernant ces objets, et susceptibles de 1) donner un supplément d'intére^t aux données astrométriques fournies par Hipparcos, 2) permettre de préciser les objectifs contenus dans diverses propositions.

  12. Rapid and cost-effective identification and antimicrobial susceptibility testing in patients with Gram-negative bacteremia directly from blood-culture fluid.

    PubMed

    Sakarikou, Christina; Altieri, Anna; Bossa, Maria Cristina; Minelli, Silvia; Dolfa, Camilla; Piperno, Micol; Favalli, Cartesio

    2018-03-01

    Rapid pathogen identification (ID) and antimicrobial susceptibility testing (AST) in bacteremia cases or sepsis could improve patient prognosis. Thus, it is important to provide timely reports, which make it possible for clinicians to set up appropriate antibiotic therapy during the early stages of bloodstream infection (BSI). This study evaluates an in-house microbiological protocol for early ID as well as AST on Gram negative bacteria directly from positive monomicrobial and polymicrobial blood cultures (BCs). A total of 102 non-duplicated positive BCs from patients with Gram-negative bacteremia were tested. Both IDs and ASTs were performed from bacterial pellets extracted directly from BCs using our protocol, which was applied through the combined use of a MALDI-TOF MS and Vitek2 automated system. The results of our study showed a 100% agreement in bacterial ID and 98.25% categorical agreement in AST when compared to those obtained by routine conventional methods. We recorded only a 0.76% minor error (mE), 0.76% major error (ME) and a 0.20% very major error (VME). Moreover, the turnaround time (TAT) regarding the final AST report was significantly shortened (ΔTAT = 8-20 h, p < 0.00001). This in-house protocol is rapid, easy to perform and cost effective and could be successfully introduced into any clinical microbiology laboratory. A final same-day report of ID and AST improves patient management, by early and appropriate antimicrobial treatment and could potentially optimize antimicrobial stewardship programs. Copyright © 2018 Elsevier B.V. All rights reserved.

  13. AzTEC/ASTE 1.1 mm Deep Surveys: Number Counts and Clustering of Millimeter-bright Galaxies

    NASA Astrophysics Data System (ADS)

    Hatsukade, B.

    2011-11-01

    We present results of a 1.1 mm deep survey of the AKARI Deep Field South (ADF-S) with AzTEC mounted on the Atacama Submillimetre Telescope Experiment (ASTE). We obtained a map of 0.25 deg2 area with an rms noise level of 0.32-0.71 mJy. This is one of the deepest and widest maps thus far at millimetre and submillimetre wavelengths. We uncovered 198 sources with a significance of 3.5-15.6σ, providing the largest catalog of 1.1 mm sources in a contiguous region. Most of the sources are not detected in the far-infrared bands of the AKARI satellite, suggesting that they are mostly at z ≥ 1.5 given the detection limits. We construct differential and cumulative number counts of the ADF-S, the Subaru/XMM Newton Deep Field (SXDF), and the SSA 22 field surveyed by AzTEC/ASTE, which provide currently the tightest constraints on the faint end. The integration of the differential number counts of the ADF-S find that the contribution of 1.1 mm sources with ≥1 mJy to the cosmic infrared background (CIB) at 1.1 mm is 12-16%, suggesting that the large fraction of the CIB originates from faint sources of which number counts are not yet constrained. We estimate the cosmic star-formation rate density contributed by 1.1 mm sources with ≥1 mJy using the differential number counts and find that it is lower by about a factor of 5-10 compared to those derived from UV/optically-selected galaxies at z ~ 2-3. Clustering analyses of AzTEC sources in the ADF-S and the SXDF find that bright (>3 mJy) AzTEC sources are more strongly clustered than faint (< 3 mJy) AzTEC sources and the average mass of dark halos hosting bright AzTEC sources was calculated to be 1013-1014M⊙. Comparison of correlation length of AzTEC sources with other populations and with a bias evolution model suggests that dark halos hosting bright AzTEC sources evolve into systems of clusters at present universe and the AzTEC sources residing the dark halos evolve into massive elliptical galaxies located in the center of

  14. WSR-88D doppler radar detection of corn earworm moth migration.

    PubMed

    Westbrook, J K; Eyster, R S; Wolf, W W

    2014-07-01

    Corn earworm (Lepidoptera: Noctuidae) (CEW) populations infesting one crop production area may rapidly migrate and infest distant crop production areas. Although entomological radars have detected corn earworm moth migrations, the spatial extent of the radar coverage has been limited to a small horizontal view above crop production areas. The Weather Service Radar (version 88D) (WSR-88D) continuously monitors the radar-transmitted energy reflected by, and radial speed of, biota as well as by precipitation over areas that may encompass crop production areas. We analyzed data from the WSR-88D radar (S-band) at Brownsville, Texas, and related these data to aerial concentrations of CEW estimated by a scanning entomological radar (X-band) and wind velocity measurements from rawinsonde and pilot balloon ascents. The WSR-88D radar reflectivity was positively correlated (r2=0.21) with the aerial concentration of corn earworm-size insects measured by a scanning X-band radar. WSR-88D radar constant altitude plan position indicator estimates of wind velocity were positively correlated with wind speed (r2=0.56) and wind direction (r2=0.63) measured by pilot balloons and rawinsondes. The results reveal that WSR-88D radar measurements of insect concentration and displacement speed and direction can be used to estimate the migratory flux of corn earworms and other nocturnal insects, information that could benefit areawide pest management programs. In turn, identification of the effects of spatiotemporal patterns of migratory flights of corn earworm-size insects on WSR-88D radar measurements may lead to the development of algorithms that increase the accuracy of WSR-88D radar measurements of reflectivity and wind velocity for operational meteorology.

  15. WSR-88D doppler radar detection of corn earworm moth migration

    NASA Astrophysics Data System (ADS)

    Westbrook, J. K.; Eyster, R. S.; Wolf, W. W.

    2014-07-01

    Corn earworm (Lepidoptera: Noctuidae) (CEW) populations infesting one crop production area may rapidly migrate and infest distant crop production areas. Although entomological radars have detected corn earworm moth migrations, the spatial extent of the radar coverage has been limited to a small horizontal view above crop production areas. The Weather Service Radar (version 88D) (WSR-88D) continuously monitors the radar-transmitted energy reflected by, and radial speed of, biota as well as by precipitation over areas that may encompass crop production areas. We analyzed data from the WSR-88D radar (S-band) at Brownsville, Texas, and related these data to aerial concentrations of CEW estimated by a scanning entomological radar (X-band) and wind velocity measurements from rawinsonde and pilot balloon ascents. The WSR-88D radar reflectivity was positively correlated ( r 2 = 0.21) with the aerial concentration of corn earworm-size insects measured by a scanning X-band radar. WSR-88D radar constant altitude plan position indicator estimates of wind velocity were positively correlated with wind speed ( r 2 = 0.56) and wind direction ( r 2 = 0.63) measured by pilot balloons and rawinsondes. The results reveal that WSR-88D radar measurements of insect concentration and displacement speed and direction can be used to estimate the migratory flux of corn earworms and other nocturnal insects, information that could benefit areawide pest management programs. In turn, identification of the effects of spatiotemporal patterns of migratory flights of corn earworm-size insects on WSR-88D radar measurements may lead to the development of algorithms that increase the accuracy of WSR-88D radar measurements of reflectivity and wind velocity for operational meteorology.

  16. Vaginal vault suspension during hysterectomy for benign indications: a prospective register study of agreement on terminology and surgical procedure.

    PubMed

    Bonde, Lisbeth; Noer, Mette Calundann; Møller, Lars Alling; Ottesen, Bent; Gimbel, Helga

    2017-07-01

    Several suspension methods are used to try to prevent pelvic organ prolapse (POP) after hysterectomy. We aimed to evaluate agreement on terminology and surgical procedure of these methods. We randomly chose 532 medical records of women with a history of hysterectomy from the Danish Hysterectomy and Hysteroscopy Database (DHHD). Additionally, we video-recorded 36 randomly chosen hysterectomies. The hysterectomies were registered in the DHHD. The material was categorized according to predefined suspension methods. Agreement compared suspension codes in DHHD (gynecologists' registrations) with medical records (gynecologists' descriptions) and with videos (reviewers' categorizations) respectively. Whether the vaginal vault was suspended (pooled suspension) or not (no suspension method + not described) was analyzed, in addition to each suspension method. Regarding medical records, agreement on terminology was good among patients undergoing pooled suspension in cases of hysterectomy via the abdominal and vaginal route (agreement 78.7, 92.3%). Regarding videos, agreement on surgical procedure was good among pooled suspension patients in cases of hysterectomy via the abdominal, laparoscopic, and vaginal routes (agreement 88.9, 97.8, 100%). Agreement on individual suspension methods differed regarding both medical records (agreement 0-90.1%) and videos (agreement 0-100%). Agreement on terminology and surgical procedure regarding suspension method was good in respect of pooled suspension. However, disagreement was observed when individual suspension methods and operative details were scrutinized. Better consensus of terminology and surgical procedure is warranted to enable further research aimed at preventing POP among women undergoing hysterectomy.

  17. Successful associateship agreements.

    PubMed

    Crafton, B C

    1997-08-01

    When evaluating potential associateship agreements, dentists need to recognize and understand how status, noncompete clauses, scheduling and compensation affect the strength of an associateship agreement. Dentists should not enter an associateship agreement without fully understanding the agreement and its obligations or without the help of an accountant and an attorney.

  18. National Weather Service Warning Performance Based on the WSR-88D.

    NASA Astrophysics Data System (ADS)

    Polger, Paul D.; Goldsmith, Barry S.; Przywarty, Richard C.; Bocchieri, Joseph R.

    1994-02-01

    The National Weather Service (NWS) began operational use of the Weather Surveillance Radar-1988 Doppler (WSR-88D) system in March 1991 at Norman, Oklahoma. WSR-88D data have been available to forecasters at five additional offices: Melbourne, Florida, and sterling, Virginia (since January 1992); St. Louis, Missouri, and Dodge City, Kansas (since March 1992); and Houston, Texas (since April 1992). The performance of the severe local storm and flash flood warning programs at the six offices before and after the availability of the WSR-88D was measured quantitatively. The verification procedures and statistical measures used in the quantitative evaluation were those used operationally by the NWS.The statistics show that the warnings improved dramatically when the WSR-88D was in operation. Specifically, the probability of detection of severe weather events increased and the number of false alarms decreased. There was also a marked improvement in the lead time for all severe local storm and flash flood events. These improvements were evident throughout the effective range of the radar. Stratification of severe local storm data by severe thunderstorms versus tornadoes revealed an improvement in the NWS's ability to differentiate between tornadic and nontornadic storms when the WSR-88D was in operation. Four individual cases are examined to illustrate how forecasters used the WSR-88D to achieve the improved results. These cases focus on the unique features of the WSR-88D that provide an advantage over conventional NWS radars.

  19. A Statistical Analysis of Reviewer Agreement and Bias in Evaluating Medical Abstracts 1

    PubMed Central

    Cicchetti, Domenic V.; Conn, Harold O.

    1976-01-01

    Observer variability affects virtually all aspects of clinical medicine and investigation. One important aspect, not previously examined, is the selection of abstracts for presentation at national medical meetings. In the present study, 109 abstracts, submitted to the American Association for the Study of Liver Disease, were evaluated by three “blind” reviewers for originality, design-execution, importance, and overall scientific merit. Of the 77 abstracts rated for all parameters by all observers, interobserver agreement ranged between 81 and 88%. However, corresponding intraclass correlations varied between 0.16 (approaching statistical significance) and 0.37 (p < 0.01). Specific tests of systematic differences in scoring revealed statistically significant levels of observer bias on most of the abstract components. Moreover, the mean differences in interobserver ratings were quite small compared to the standard deviations of these differences. These results emphasize the importance of evaluating the simple percentage of rater agreement within the broader context of observer variability and systematic bias. PMID:997596

  20. Agreement among orthodontists experienced with cone-beam computed tomography on the need for follow-up and the clinical impact of craniofacial findings from multiplanar and 3-dimensional reconstructed views.

    PubMed

    Edwards, Ryan; Alsufyani, Noura; Heo, Giseon; Flores-Mir, Carlos

    2015-08-01

    In this study, we aimed to assess interrater and intrarater agreement among orthodontic clinicians in their assessments of reported incidental findings in regard to both the need for additional follow-up and the impact on future orthodontic treatment in large-field maxillofacial cone-beam computed tomography (CBCT) imaging. The study sample consisted of 18 nonrandomly selected large-field maxillofacial CBCT volumes containing a reported total of 88 radiographic findings. All scans were associated with formal radiologic reports. However, the suggestions of further follow-up were removed from the radiologic reports so as to not bias the 3 evaluating orthodontists in their subsequent decision making. The evaluators had on average 7.6 years of CBCT usage and self-interpretation experience. Reliability was determined by quantifying the level of agreement between the evaluators' assessments for both research questions for all 88 findings using a binary response (yes/no) as the outcome measure. The Cohen kappa statistic was calculated to quantify intrarater and interrater agreement globally for both statements. Although interrater agreement was considerable, potential decisions with clinical impact were not consistent. This needs to be considered when interpreting maxillofacial incidental findings. Evaluators demonstrated higher levels of agreement for dentoalveolar findings compared with all other extragnathic regions when assessing clinical significance. Among the evaluators who were considered experienced in CBCT, "fair-to-good" interrater agreement and "excellent" intrarater agreement were demonstrated in terms of the need for further follow-up and their potential impact on future orthodontic treatment. Copyright © 2015 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

  1. 42 CFR 412.88 - Additional payment for new medical service or technology.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... technology. 412.88 Section 412.88 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... Payments for Outlier Cases, Special Treatment Payment for New Technology, and Payment Adjustment for Certain Replaced Devices Additional Special Payment for Certain New Technology § 412.88 Additional payment...

  2. 42 CFR 412.88 - Additional payment for new medical service or technology.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... technology. 412.88 Section 412.88 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... Payments for Outlier Cases, Special Treatment Payment for New Technology, and Payment Adjustment for Certain Replaced Devices Additional Special Payment for Certain New Technology § 412.88 Additional payment...

  3. 42 CFR 412.88 - Additional payment for new medical service or technology.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... technology. 412.88 Section 412.88 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... Payments for Outlier Cases, Special Treatment Payment for New Technology, and Payment Adjustment for Certain Replaced Devices Additional Special Payment for Certain New Technology § 412.88 Additional payment...

  4. 42 CFR 412.88 - Additional payment for new medical service or technology.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... technology. 412.88 Section 412.88 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... Payments for Outlier Cases, Special Treatment Payment for New Technology, and Payment Adjustment for Certain Replaced Devices Additional Special Payment for Certain New Technology § 412.88 Additional payment...

  5. MyD88 and TLR4 Expression in Epithelial Ovarian Cancer

    PubMed Central

    Block, Matthew S.; Vierkant, Robert A.; Rambau, Peter F.; Winham, Stacey J.; Wagner, Philipp; Traficante, Nadia; Tołoczko, Aleksandra; Tiezzi, Daniel G.; Taran, Florin Andrei; Sinn, Peter; Sieh, Weiva; Sharma, Raghwa; Rothstein, Joseph H.; Cajal, Teresa Ramón y; Paz-Ares, Luis; Oszurek, Oleg; Orsulic, Sandra; Ness, Roberta B.; Nelson, Gregg; Modugno, Francesmary; Menkiszak, Janusz; McGuire, Valerie; McCauley, Bryan M.; Mack, Marie; Lubiński, Jan; Longacre, Teri A.; Li, Zheng; Lester, Jenny; Kennedy, Catherine J.; Kalli, Kimberly R.; Jung, Audrey Y.; Johnatty, Sharon E.; Jimenez-Linan, Mercedes; Jensen, Allan; Intermaggio, Maria P.; Hung, Jillian; Herpel, Esther; Hernandez, Brenda Y.; Hartkopf, Andreas D.; Harnett, Paul R.; Ghatage, Prafull; García-Bueno, José M.; Gao, Bo; Fereday, Sian; Eilber, Ursula; Edwards, Robert P.; de Sousa, Christiani B.; de Andrade, Jurandyr M.; Chudecka-Głaz, Anita; Chenevix-Trench, Georgia; Cazorla, Alicia; Brucker, Sara Y.; Alsop, Jennifer; Whittemore, Alice S.; Steed, Helen; Staebler, Annette; Moysich, Kirsten B.; Menon, Usha; Koziak, Jennifer M.; Kommoss, Stefan; Kjaer, Susanne K.; Kelemen, Linda E.; Karlan, Beth Y.; Huntsman, David G.; Høgdall, Estrid; Gronwald, Jacek; Goodman, Marc T.; Gilks, Blake; García, María José; Fasching, Peter A.; de Fazio, Anna; Deen, Suha; Chang-Claude, Jenny; Candido dos Reis, Francisco J.; Campbell, Ian G.; Brenton, James D.; Bowtell, David D.; Benítez, Javier; Pharoah, Paul D.P.; Köbel, Martin; Ramus, Susan J.; Goode, Ellen L.

    2018-01-01

    Objective To evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival. Patients and Methods We conducted centralized immunohistochemical staining, semi-quantitative scoring, and survival analysis in 5263 patients participating in the Ovarian Tumor Tissue Analysis consortium. Patients were diagnosed between January 1, 1978, and December 31, 2014, including 2865 high-grade serous ovarian carcinomas (HGSOCs), with more than 12,000 person-years of follow-up time. Tissue microarrays were stained for MyD88 and TLR4, and staining intensity was classified using a 2-tiered system for each marker (weak vs strong). Results Expression of MyD88 and TLR4 was similar in all histotypes except clear cell ovarian cancer, which showed reduced expression compared with other histotypes (P<.001 for both). In HGSOC, strong MyD88 expression was modestly associated with shortened overall survival (hazard ratio [HR], 1.13; 95% CI, 1.01–1.26; P=.04) but was also associated with advanced stage (P<.001). The expression of TLR4 was not associated with survival. In low-grade serous ovarian cancer (LGSOC), strong expression of both MyD88 and TLR4 was associated with favorable survival (HR [95% CI], 0.49 [0.29–0.84] and 0.44 [0.21–0.89], respectively; P=.009 and P=.02, respectively). Conclusion Results are consistent with an association between strong MyD88 staining and advanced stage and poorer survival in HGSOC and demonstrate correlation between strong MyD88 and TLR4 staining and improved survival in LGSOC, highlighting the biological differences between the 2 serous histotypes. PMID:29502561

  6. MyD88 and TLR4 Expression in Epithelial Ovarian Cancer.

    PubMed

    Block, Matthew S; Vierkant, Robert A; Rambau, Peter F; Winham, Stacey J; Wagner, Philipp; Traficante, Nadia; Tołoczko, Aleksandra; Tiezzi, Daniel G; Taran, Florin Andrei; Sinn, Peter; Sieh, Weiva; Sharma, Raghwa; Rothstein, Joseph H; Ramón Y Cajal, Teresa; Paz-Ares, Luis; Oszurek, Oleg; Orsulic, Sandra; Ness, Roberta B; Nelson, Gregg; Modugno, Francesmary; Menkiszak, Janusz; McGuire, Valerie; McCauley, Bryan M; Mack, Marie; Lubiński, Jan; Longacre, Teri A; Li, Zheng; Lester, Jenny; Kennedy, Catherine J; Kalli, Kimberly R; Jung, Audrey Y; Johnatty, Sharon E; Jimenez-Linan, Mercedes; Jensen, Allan; Intermaggio, Maria P; Hung, Jillian; Herpel, Esther; Hernandez, Brenda Y; Hartkopf, Andreas D; Harnett, Paul R; Ghatage, Prafull; García-Bueno, José M; Gao, Bo; Fereday, Sian; Eilber, Ursula; Edwards, Robert P; de Sousa, Christiani B; de Andrade, Jurandyr M; Chudecka-Głaz, Anita; Chenevix-Trench, Georgia; Cazorla, Alicia; Brucker, Sara Y; Alsop, Jennifer; Whittemore, Alice S; Steed, Helen; Staebler, Annette; Moysich, Kirsten B; Menon, Usha; Koziak, Jennifer M; Kommoss, Stefan; Kjaer, Susanne K; Kelemen, Linda E; Karlan, Beth Y; Huntsman, David G; Høgdall, Estrid; Gronwald, Jacek; Goodman, Marc T; Gilks, Blake; García, María José; Fasching, Peter A; de Fazio, Anna; Deen, Suha; Chang-Claude, Jenny; Candido Dos Reis, Francisco J; Campbell, Ian G; Brenton, James D; Bowtell, David D; Benítez, Javier; Pharoah, Paul D P; Köbel, Martin; Ramus, Susan J; Goode, Ellen L

    2018-03-01

    To evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival. We conducted centralized immunohistochemical staining, semi-quantitative scoring, and survival analysis in 5263 patients participating in the Ovarian Tumor Tissue Analysis consortium. Patients were diagnosed between January 1, 1978, and December 31, 2014, including 2865 high-grade serous ovarian carcinomas (HGSOCs), with more than 12,000 person-years of follow-up time. Tissue microarrays were stained for MyD88 and TLR4, and staining intensity was classified using a 2-tiered system for each marker (weak vs strong). Expression of MyD88 and TLR4 was similar in all histotypes except clear cell ovarian cancer, which showed reduced expression compared with other histotypes (P<.001 for both). In HGSOC, strong MyD88 expression was modestly associated with shortened overall survival (hazard ratio [HR], 1.13; 95% CI, 1.01-1.26; P=.04) but was also associated with advanced stage (P<.001). The expression of TLR4 was not associated with survival. In low-grade serous ovarian cancer (LGSOC), strong expression of both MyD88 and TLR4 was associated with favorable survival (HR [95% CI], 0.49 [0.29-0.84] and 0.44 [0.21-0.89], respectively; P=.009 and P=.02, respectively). Results are consistent with an association between strong MyD88 staining and advanced stage and poorer survival in HGSOC and demonstrate correlation between strong MyD88 and TLR4 staining and improved survival in LGSOC, highlighting the biological differences between the 2 serous histotypes. Copyright © 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  7. 40 CFR 88.302-94 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .../engine conversion configuration pursuant to the requirements of 40 CFR part 86 and this part 88. Control... combination of vehicle/engine conversion hardware and a base vehicle of a specific engine family. Covered... vehicle component manufacturer, or owned or held by a university research department, independent testing...

  8. 40 CFR 88.302-94 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .../engine conversion configuration pursuant to the requirements of 40 CFR part 86 and this part 88. Control... combination of vehicle/engine conversion hardware and a base vehicle of a specific engine family. Covered... vehicle component manufacturer, or owned or held by a university research department, independent testing...

  9. 40 CFR 88.302-94 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .../engine conversion configuration pursuant to the requirements of 40 CFR part 86 and this part 88. Control... combination of vehicle/engine conversion hardware and a base vehicle of a specific engine family. Covered... vehicle component manufacturer, or owned or held by a university research department, independent testing...

  10. 40 CFR 88.302-94 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .../engine conversion configuration pursuant to the requirements of 40 CFR part 86 and this part 88. Control... combination of vehicle/engine conversion hardware and a base vehicle of a specific engine family. Covered... vehicle component manufacturer, or owned or held by a university research department, independent testing...

  11. 40 CFR 88.302-94 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .../engine conversion configuration pursuant to the requirements of 40 CFR part 86 and this part 88. Control... combination of vehicle/engine conversion hardware and a base vehicle of a specific engine family. Covered... vehicle component manufacturer, or owned or held by a university research department, independent testing...

  12. 9 CFR 88.2 - General information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... EQUINES FOR SLAUGHTER § 88.2 General information. (a) State governments may enact and enforce regulations... whether an individual or other entity found to transport equines to a slaughtering facility is subject to... who transported the equines information regarding the business of that individual or other entity...

  13. 40 CFR 88.311-98 - Emissions standards for Inherently Low-Emission Vehicles.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Emissions standards for Inherently Low-Emission Vehicles. 88.311-98 Section 88.311-98 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... standards for Inherently Low-Emission Vehicles. Section 88.311-98 includes text that specifies requirements...

  14. MYD88 Inhibitor ST2825 Suppresses the Growth of Lymphoma and Leukaemia Cells.

    PubMed

    Shiratori, Erika; Itoh, Mai; Tohda, Shuji

    2017-11-01

    Myeloid differentiation primary response gene 88 (MYD88), which activates the nuclear factor kappa B (NF-κB) pathway, is important for the growth of lymphoma and leukaemia cells. In this study, we investigated the effects of ST2825, a synthetic peptidomimetic compound which inhibits MYD88 homodimerization, on their growth. Seven lymphoma and leukaemia cell lines including TMD8, a B-cell lymphoma line with MYD88-activating mutation, were treated with ST2825 and analysed for cell proliferation and expression of NF-κB signalling-related molecules. ST2825 suppressed the growth of all cell lines by inducing apoptosis and down-regulating phosphorylation of NF-κB pathway components inhibitor of nuclear factor kappa B kinase (IκB) and reticuloendotheliosis oncogene A (RelA), as well as of MYD88 activator Bruton tyrosine kinase (BTK), suggesting that MYD88 may affect BTK activity. ST2825 effects were specific as MYD88-targeting siRNA also suppressed phosphorylation of NF-κB signalling proteins and BTK in TMD8 cells. ST2825 may be a novel drug targeting not only B-lymphoid malignancies with MYD88 mutations, but also lymphoma and leukaemia with wild-type MYD88. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  15. 21 CFR 520.88a - Amoxicillin trihydrate film-coated tablets.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Amoxicillin trihydrate film-coated tablets. 520.88a Section 520.88a Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Amoxicillin trihydrate film-coated tablets. (a) Specifications. Each tablet contains amoxicillin trihydrate...

  16. 10 CFR 1040.88 - Remedial and affirmative action by recipients.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Remedial and affirmative action by recipients. 1040.88... Standards for Determining Age Discrimination § 1040.88 Remedial and affirmative action by recipients. (a... take affirmative action to overcome the effects of conditions that resulted in limited participation in...

  17. 10 CFR 1040.88 - Remedial and affirmative action by recipients.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Remedial and affirmative action by recipients. 1040.88... Standards for Determining Age Discrimination § 1040.88 Remedial and affirmative action by recipients. (a... take affirmative action to overcome the effects of conditions that resulted in limited participation in...

  18. Predominance of the ac variant in K88-positive Escherichia coli isolates from swine.

    PubMed Central

    Westerman, R B; Mills, K W; Phillips, R M; Fortner, G W; Greenwood, J M

    1988-01-01

    Monoclonal antibodies to K88ac and K88ab were used in enzyme-linked immunosorbent assays on Escherichia coli cultures known to produce K88 pili. A total of 415 K88-positive E. coli isolates from nine states were all found to be the K88ac variant. The cultures tested were isolated during the years 1976 to 1985. PMID:3277990

  19. 36 CFR 223.88 - Bidding methods.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Bidding methods. 223.88... methods. (a) Competitive sales of National Forest timber shall be offered through either sealed or oral auction bidding. The method chosen for each sale will: (1) Insure open and fair competition, (2) Insure...

  20. 40 CFR 88.102-94 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) CLEAN-FUEL VEHICLES Emission Standards for Clean-Fuel Vehicles § 88.102-94 Definitions. Any terms... and the GVWR. Dual Fuel Vehicle (or Engine) means any motor vehicle (or motor vehicle engine) engineered and designed to be operated on two different fuels, but not on a mixture of the fuels. Flexible...

  1. 25 CFR 88.2 - Employment by tribes or individual claimants.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Employment by tribes or individual claimants. 88.2 Section... ATTORNEYS AND AGENTS TO REPRESENT CLAIMANTS § 88.2 Employment by tribes or individual claimants. All such attorneys or agents seeking approval of their employment by Indian tribes or desiring to represent...

  2. 25 CFR 88.2 - Employment by tribes or individual claimants.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Employment by tribes or individual claimants. 88.2... ATTORNEYS AND AGENTS TO REPRESENT CLAIMANTS § 88.2 Employment by tribes or individual claimants. All such attorneys or agents seeking approval of their employment by Indian tribes or desiring to represent...

  3. 25 CFR 88.2 - Employment by tribes or individual claimants.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Employment by tribes or individual claimants. 88.2... ATTORNEYS AND AGENTS TO REPRESENT CLAIMANTS § 88.2 Employment by tribes or individual claimants. All such attorneys or agents seeking approval of their employment by Indian tribes or desiring to represent...

  4. 25 CFR 88.2 - Employment by tribes or individual claimants.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Employment by tribes or individual claimants. 88.2... ATTORNEYS AND AGENTS TO REPRESENT CLAIMANTS § 88.2 Employment by tribes or individual claimants. All such attorneys or agents seeking approval of their employment by Indian tribes or desiring to represent...

  5. 25 CFR 88.2 - Employment by tribes or individual claimants.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Employment by tribes or individual claimants. 88.2... ATTORNEYS AND AGENTS TO REPRESENT CLAIMANTS § 88.2 Employment by tribes or individual claimants. All such attorneys or agents seeking approval of their employment by Indian tribes or desiring to represent...

  6. 9 CFR 88.6 - Violations and penalties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... TRANSPORTATION OF EQUINES FOR SLAUGHTER § 88.6 Violations and penalties. (a) The Secretary is authorized to... equine transported in violation of the regulations of this part will be considered a separate violation...

  7. 1987-88 Statewide Computer Survey Report.

    ERIC Educational Resources Information Center

    South Carolina Educational Television Network Columbia.

    This fifth annual survey of computers and their use in South Carolina schools covers the 1978-88 school years. A questionnaire inventoried computer equipment and software, and dealt with such issues as instructional and administrative uses of computers, and availability of funding. The forms were distributed to all South Carolina public school…

  8. Project MASTER, 1987-88. OREA Report.

    ERIC Educational Resources Information Center

    Berney, Tomi D.; Hammack, Floyd

    Project MASTER completed its 3-year funding cycle in 1987-88. The project aimed at providing enhanced science instruction to 575 Spanish-speaking limited-English-proficient students in 5 elementary schools. Project MASTER offered classes in English as a Second Language (ESL), mathematics, science, and computer skills with a hands-on, integrated…

  9. Agreement between clinical and MINI diagnoses in outpatients with mood and anxiety disorders.

    PubMed

    Verhoeven, F E A; Swaab, L S M A; Carlier, I V E; van Hemert, A M; Zitman, F G; Ruhé, H G; Schoevers, R A; Giltay, E J

    2017-10-15

    Standardized Diagnostic Interviews (SDIs) such as the Mini International Neuropsychiatric Interview (MINI) are widely used to systematically screen for psychiatric disorders in research. To support generalizability of results to clinical practice, we assessed agreement between the MINI and clinical diagnoses. Agreement was assessed in a large, real life dataset (n = 7016) using concordance statistics such as sensitivity, specificity, efficiency and area under the curve (AUC). 41.5% of clinical diagnoses were mood disorders, 26.5% were anxiety disorders. Overall, we found moderate agreement between MINI and clinical diagnoses (median efficiency: 0.92, median AUC: 0.79). For mood disorders, the AUC for all participants showed a range between 0.55 and 0.81 (median: 0.73), and for anxiety disorders the AUC ranged from 0.78 to 0.88 (median: 0.83). The AUC showed better agreement for mood disorders in the single diagnosis group than in the total group (median 0.77 vs. 0.71). For anxiety disorders, the AUC for the single diagnosis group was comparable to the AUC of the total group (median: 0.81 vs. 0.83 respectively). Numbers of false positives were high for both mood and anxiety diagnoses, but less so in the single diagnosis group. Time lag between MINI and clinical diagnosis, the availability of only the primary clinical diagnosis, and relatively high severity of the current sample are limitations of the current study. Agreement between MINI and clinical diagnoses was moderate at best, which partly reflects the difference between the different measures used in the current study. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Immobilization stress-induced anorexia is mediated independent of MyD88.

    PubMed

    Hosoi, Toru; Yamawaki, Yosuke; Kimura, Hitomi; Ozawa, Koichiro

    2016-09-07

    MyD88 is an adaptor protein for the toll-like receptor, which is involved in regulating innate immune function. Lipopolysaccharide-induced activation of toll-like receptor 4 signaling induces hypothalamic signal transducer and activator of transcription 3 (STAT3) phosphorylation and anorexia through MyD88. In the present study, we investigated the possible role of MyD88 in psychological stress-induced anorexia. We found that immobilization stress inhibited food intake in both wild-type mice and MyD88-deficient mice. Immobilization stress slightly increased STAT3 phosphorylation in the hypothalamus, but it was weaker than the lipopolysaccharide-induced increase in STAT3 phosphorylation. These observations suggest that the mechanisms involved in psychological stress-induced anorexia may be regulated differently from those involved in anorexia that is induced by infection.

  11. Efficacy and tolerability of diphenyl-dimethyl-dicarboxylate plus garlic oil in patients with chronic hepatitis.

    PubMed

    Lee, Min Ho; Kim, Young Mi; Kim, Sang Geon

    2012-11-01

    To investigate the hepatoprotective effect, safety and tolerability of oral preparation comprising dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB) plus garlic oil (GO) in chronic hepatitis patients. In this double-blind, placebo-controlled clinical trial conducted for 6 weeks with 1-week follow-up, a total of 88 patients with histologically confirmed chronic hepatitis and persistently elevated levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were enrolled and randomly assigned to one of 4 treatment groups: placebo (Group A) and 3 escalating dose groups (2, 3, or 6 study drug capsules a day) (Groups B - D). Each study drug capsule contains 25 mg DDB plus 50 mg GO. Efficacy was assessed by monitoring changes in the circulating activities of ALT and AST as surrogate markers for liver injury. Safety and tolerability were assessed based on the evaluation of clinically adverse events and laboratory test results. Of 88 patients, 83 took at least one dose of study drug and 79 completed the study without any protocol violation. The majority of patients (81/83, 98%) had been infected with HBV. The proportions of patients whose ALT levels returned to normal ranges at Week 6, a primary outcome, were significantly different among 4 groups: 16% (3/19), 41% (9/22), 52% (11/21), and 88% (15/17) in Groups A, B, C, and D, respectively (p < 0.001). The proportions were significantly higher in Groups C (p = 0.022) and D (p < 0.001) but not in Group B compared to Group A. Interestingly, the proportion of Group D was higher than that of Group C (p = 0.034), suggesting a dose-response effect of DDB plus GO on the decrease of ALT levels. The mean ALT levels started to decrease from Week 1 in patients treated with DDB plus GO, whereas no decrease was seen in placebo group. The mean AST levels had a decreasing trend in all doses of DDB plus GO groups. Notably, patients treated with 6 capsules of DDB plus GO daily exhibited

  12. A new experimental method for the determination of the effective orifice area based on the acoustical source term

    NASA Astrophysics Data System (ADS)

    Kadem, L.; Knapp, Y.; Pibarot, P.; Bertrand, E.; Garcia, D.; Durand, L. G.; Rieu, R.

    2005-12-01

    The effective orifice area (EOA) is the most commonly used parameter to assess the severity of aortic valve stenosis as well as the performance of valve substitutes. Particle image velocimetry (PIV) may be used for in vitro estimation of valve EOA. In the present study, we propose a new and simple method based on Howe’s developments of Lighthill’s aero-acoustic theory. This method is based on an acoustical source term (AST) to estimate the EOA from the transvalvular flow velocity measurements obtained by PIV. The EOAs measured by the AST method downstream of three sharp-edged orifices were in excellent agreement with the EOAs predicted from the potential flow theory used as the reference method in this study. Moreover, the AST method was more accurate than other conventional PIV methods based on streamlines, inflexion point or vorticity to predict the theoretical EOAs. The superiority of the AST method is likely due to the nonlinear form of the AST. There was also an excellent agreement between the EOAs measured by the AST method downstream of the three sharp-edged orifices as well as downstream of a bioprosthetic valve with those obtained by the conventional clinical method based on Doppler-echocardiographic measurements of transvalvular velocity. The results of this study suggest that this new simple PIV method provides an accurate estimation of the aortic valve flow EOA. This new method may thus be used as a reference method to estimate the EOA in experimental investigation of the performance of valve substitutes and to validate Doppler-echocardiographic measurements under various physiologic and pathologic flow conditions.

  13. Rapid disc diffusion antibiotic susceptibility testing for Pseudomonas aeruginosa, Acinetobacter baumannii and Enterococcus spp.

    PubMed Central

    Hombach, Michael; Jetter, Marion; Blöchliger, Nicolas; Kolesnik-Goldmann, Natalia; Keller, Peter M; Böttger, Erik C

    2018-01-01

    Abstract Background We investigated the feasibility of rapid disc diffusion antibiotic susceptibility testing (rAST) with reading of inhibition zones after 6 and/or 8 h of incubation for Enterococcus faecalis, Enterococcus faecium, Pseudomonas aeruginosa and Acinetobacter baumannii. In addition, we evaluated discrimination of resistant populations from the WT populations at early timepoints and the requirement for clinical breakpoint adaptations for proper interpretation of rAST data. Methods In total, 815 clinical strains [E. faecalis (n = 135), E. faecium (n = 227), P. aeruginosa (n = 295) and A. baumannii (n = 158)] were included in this study. Disc diffusion plates were streaked, incubated and imaged using the WASPLabTM automation system. WT populations and non-WT populations were defined using epidemiological cut-offs. Results and conclusions rAST at 6 and 8 h was possible for A. baumannii and enterococci with readability of inhibition zones >90%. Overall categorical agreement of rAST at 6 h with AST at 18 h was 97.2%, 97.4% and 95.3% for E. faecalis, E. faecium and A. baumannii, respectively. With few exceptions, major categorization error rates were <1% for A. baumannii, and vancomycin-resistant E. faecium were clearly separated from the WT at 6 h. For P. aeruginosa the average readability of inhibition zones was 68.9% at 8 h and we found an overall categorical agreement of 94.8%. Adaptations of clinical breakpoints and/or introduction of technical buffer zones, preferably based on aggregated population data from various epidemiological settings, are required for proper interpretation of rAST. PMID:29186434

  14. 7 CFR 3300.88 - Fees for U.S. ATP certificates.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Fees for U.S. ATP certificates. 3300.88 Section 3300... EQUIPMENT TO BE USED FOR SUCH CARRIAGE (ATP); INSPECTION, TESTING, AND CERTIFICATION OF SPECIAL EQUIPMENT Other Provisions § 3300.88 Fees for U.S. ATP certificates. The fee schedule for issuance of U.S. ATP...

  15. 7 CFR 3300.88 - Fees for U.S. ATP certificates.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Fees for U.S. ATP certificates. 3300.88 Section 3300... EQUIPMENT TO BE USED FOR SUCH CARRIAGE (ATP); INSPECTION, TESTING, AND CERTIFICATION OF SPECIAL EQUIPMENT Other Provisions § 3300.88 Fees for U.S. ATP certificates. The fee schedule for issuance of U.S. ATP...

  16. 7 CFR 3300.88 - Fees for U.S. ATP certificates.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Fees for U.S. ATP certificates. 3300.88 Section 3300... EQUIPMENT TO BE USED FOR SUCH CARRIAGE (ATP); INSPECTION, TESTING, AND CERTIFICATION OF SPECIAL EQUIPMENT Other Provisions § 3300.88 Fees for U.S. ATP certificates. The fee schedule for issuance of U.S. ATP...

  17. 7 CFR 3300.88 - Fees for U.S. ATP certificates.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Fees for U.S. ATP certificates. 3300.88 Section 3300... EQUIPMENT TO BE USED FOR SUCH CARRIAGE (ATP); INSPECTION, TESTING, AND CERTIFICATION OF SPECIAL EQUIPMENT Other Provisions § 3300.88 Fees for U.S. ATP certificates. The fee schedule for issuance of U.S. ATP...

  18. 7 CFR 3300.88 - Fees for U.S. ATP certificates.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Fees for U.S. ATP certificates. 3300.88 Section 3300... EQUIPMENT TO BE USED FOR SUCH CARRIAGE (ATP); INSPECTION, TESTING, AND CERTIFICATION OF SPECIAL EQUIPMENT Other Provisions § 3300.88 Fees for U.S. ATP certificates. The fee schedule for issuance of U.S. ATP...

  19. 14 CFR 34.83-34.88 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT FUEL VENTING AND EXHAUST EMISSION REQUIREMENTS FOR TURBINE ENGINE POWERED AIRPLANES Test Procedures for Engine Smoke Emissions (Aircraft Gas Turbine Engines) 34.83-34.88 [Reserved] ...

  20. 40 CFR Appendix - Tables to Subpart C of Part 88

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Tables to Subpart C of Part 88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES Clean-Fuel Fleet Program Incentives for the purchase of Inherently Low-Emission Vehicles. Pt. 88, Subpt. C, Tables Tables to Subpart C of Par...

  1. 40 CFR Appendix - Tables to Subpart C of Part 88

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Tables to Subpart C of Part 88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES Clean-Fuel Fleet Program Incentives for the purchase of Inherently Low-Emission Vehicles. Pt. 88, Subpt. C, Tables Tables to Subpart C of Par...

  2. 40 CFR Appendix - Tables to Subpart C of Part 88

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Tables to Subpart C of Part 88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES Clean-Fuel Fleet Program Incentives for the purchase of Inherently Low-Emission Vehicles. Pt. 88, Subpt. C, Tables Tables to Subpart C of Par...

  3. 40 CFR Appendix - Tables to Subpart C of Part 88

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Tables to Subpart C of Part 88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES Clean-Fuel Fleet Program Incentives for the purchase of Inherently Low-Emission Vehicles. Pt. 88, Subpt. C, Tables Tables to Subpart C of Part...

  4. 40 CFR Appendix - Tables to Subpart C of Part 88

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Tables to Subpart C of Part 88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES Clean-Fuel Fleet Program Incentives for the purchase of Inherently Low-Emission Vehicles. Pt. 88, Subpt. C, Tables Tables to Subpart C of Par...

  5. C5a Receptor (CD88) Blockade Protects against MPO-ANCA GN

    PubMed Central

    Xiao, Hong; Dairaghi, Daniel J.; Powers, Jay P.; Ertl, Linda S.; Baumgart, Trageen; Wang, Yu; Seitz, Lisa C.; Penfold, Mark E.T.; Gan, Lin; Hu, Peiqi; Lu, Bao; Gerard, Norma P.; Gerard, Craig; Schall, Thomas J.; Jaen, Juan C.; Falk, Ronald J.

    2014-01-01

    Necrotizing and crescentic GN (NCGN) with a paucity of glomerular immunoglobulin deposits is associated with ANCA. The most common ANCA target antigens are myeloperoxidase (MPO) and proteinase 3. In a manner that requires activation of the alternative complement pathway, passive transfer of antibodies to mouse MPO (anti-MPO) induces a mouse model of ANCA NCGN that closely mimics human disease. Here, we confirm the importance of C5aR/CD88 in the mediation of anti-MPO–induced NCGN and report that C6 is not required. We further demonstrate that deficiency of C5a-like receptor (C5L2) has the reverse effect of C5aR/CD88 deficiency and results in more severe disease, indicating that C5aR/CD88 engagement enhances inflammation and C5L2 engagement suppresses inflammation. Oral administration of CCX168, a small molecule antagonist of human C5aR/CD88, ameliorated anti-MPO–induced NCGN in mice expressing human C5aR/CD88. These observations suggest that blockade of C5aR/CD88 might have therapeutic benefit in patients with ANCA-associated vasculitis and GN. PMID:24179165

  6. C5a receptor (CD88) blockade protects against MPO-ANCA GN.

    PubMed

    Xiao, Hong; Dairaghi, Daniel J; Powers, Jay P; Ertl, Linda S; Baumgart, Trageen; Wang, Yu; Seitz, Lisa C; Penfold, Mark E T; Gan, Lin; Hu, Peiqi; Lu, Bao; Gerard, Norma P; Gerard, Craig; Schall, Thomas J; Jaen, Juan C; Falk, Ronald J; Jennette, J Charles

    2014-02-01

    Necrotizing and crescentic GN (NCGN) with a paucity of glomerular immunoglobulin deposits is associated with ANCA. The most common ANCA target antigens are myeloperoxidase (MPO) and proteinase 3. In a manner that requires activation of the alternative complement pathway, passive transfer of antibodies to mouse MPO (anti-MPO) induces a mouse model of ANCA NCGN that closely mimics human disease. Here, we confirm the importance of C5aR/CD88 in the mediation of anti-MPO-induced NCGN and report that C6 is not required. We further demonstrate that deficiency of C5a-like receptor (C5L2) has the reverse effect of C5aR/CD88 deficiency and results in more severe disease, indicating that C5aR/CD88 engagement enhances inflammation and C5L2 engagement suppresses inflammation. Oral administration of CCX168, a small molecule antagonist of human C5aR/CD88, ameliorated anti-MPO-induced NCGN in mice expressing human C5aR/CD88. These observations suggest that blockade of C5aR/CD88 might have therapeutic benefit in patients with ANCA-associated vasculitis and GN.

  7. 14 CFR 34.83-34.88 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT FUEL VENTING AND EXHAUST EMISSION REQUIREMENTS FOR TURBINE ENGINE POWERED AIRPLANES Test Procedures for Engine Smoke Emissions (Aircraft Gas Turbine Engines) §§ 34.83-34.88 [Reserved] ...

  8. 46 CFR 298.38 - Partnership agreements and limited liability company agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Partnership agreements and limited liability company... liability company agreements. Partnership and limited liability company agreements must be in form and...) Duration of the entity; (b) Adequate partnership or limited liability company funding requirements and...

  9. Absolute frequency measurement of the 88Sr+ clock transition using a GPS link to the SI second

    NASA Astrophysics Data System (ADS)

    Dubé, Pierre; E Bernard, John; Gertsvolf, Marina

    2017-06-01

    We report the results of a recent measurement of the absolute frequency of the 5s{{ }2}{{S}1/2} - 4d{{ }2}{{D}5/2} transition of the {{}88}\\text{Sr}{{}+} ion. The optical frequency was measured against the international atomic time realization of the SI second on the geoid as obtained by frequency transfer using a global positioning system link and the precise point positioning technique. The measurement campaign yielded more than 100 h of frequency data. It was performed with improvements to the stability and accuracy of the single-ion clock compared to the last measurement made in 2012. The single ion clock uncertainty is evaluated at 1.5× {{10}-17} when contributions from acousto-optic modulator frequency chirps and servo errors are taken into account. The stability of the ion clock is 3× {{10}-15} at 1 s averaging, a factor of three better than in the previous measurement. The results from the two measurement campaigns are in good agreement. The uncertainty of the measurement, primarily from the link to the SI second, is 0.75 Hz (1.7× {{10}-15} ). The frequency measured for the S-D clock transition of {{}88}\\text{S}{{\\text{r}}+} is {ν0}= 444 779 044 095 485.27(75) Hz.

  10. Cloning, annotation and expression analysis of mycoparasitism-related genes in Trichoderma harzianum 88.

    PubMed

    Yao, Lin; Yang, Qian; Song, Jinzhu; Tan, Chong; Guo, Changhong; Wang, Li; Qu, Lianhai; Wang, Yun

    2013-04-01

    Trichoderma harzianum 88, a filamentous soil fungus, is an effective biocontrol agent against several plant pathogens. High-throughput sequencing was used here to study the mycoparasitism mechanisms of T. harzianum 88. Plate confrontation tests of T. harzianum 88 against plant pathogens were conducted, and a cDNA library was constructed from T. harzianum 88 mycelia in the presence of plant pathogen cell walls. Randomly selected transcripts from the cDNA library were compared with eukaryotic plant and fungal genomes. Of the 1,386 transcripts sequenced, the most abundant Gene Ontology (GO) classification group was "physiological process". Differential expression of 19 genes was confirmed by real-time RT-PCR at different mycoparasitism stages against plant pathogens. Gene expression analysis revealed the transcription of various genes involved in mycoparasitism of T. harzianum 88. Our study provides helpful insights into the mechanisms of T. harzianum 88-plant pathogen interactions.

  11. Ferritin levels, inflammatory biomarkers, and mortality in peripheral arterial disease: a substudy of the Iron (Fe) and Atherosclerosis Study (FeAST) Trial.

    PubMed

    Depalma, Ralph G; Hayes, Virginia W; Chow, Bruce K; Shamayeva, Galina; May, Patricia E; Zacharski, Leo R

    2010-06-01

    This study delineated correlations between ferritin, inflammatory biomarkers, and mortality in a cohort of 100 cancer-free patients with peripheral arterial disease (PAD) participating in the Veterans Affairs (VA) Cooperative Study #410, the Iron (Fe) and Atherosclerosis Study (FeAST). FeAST, a prospective, randomized, single-blind clinical trial, tested the hypothesis that reduction of iron stores using phlebotomy would influence clinical outcomes in 1227 PAD patients randomized to iron reduction or control groups. The effects of statin administration were also examined in the Sierra Nevada Health Care (SNHC) cohort by measuring serum ferritin levels at entry and during the 6-year study period. No difference was documented between treatment groups in all-cause mortality and secondary outcomes of death plus nonfatal myocardial infarction and stroke. Iron reduction in the main study caused a significant age-related improvement in cardiovascular disease outcomes, new cancer diagnoses, and cancer-specific death. Tumor necrosis factor (TNF)-alpha, TNF-alpha receptors 1 and 2, interleukin (IL)-2, IL-6, IL-10, and high-sensitivity C reactive protein (hs-CRP) were measured at entry and at 6-month intervals for 6 years. Average levels of ferritin and lipids at entry and at the end of the study were compared. The clinical course and ferritin levels of 23 participants who died during the study were reviewed. At entry, mean age of entry was 67 +/- 9 years for the SNHCS cohort, comparable to FeAST and clinical and laboratory parameters were equivalent in substudy participants randomized to iron reduction (n = 51) or control (n = 49). At baseline, 53 participants on statins had slightly lower mean entry-level ferritin values (114.06 ng/mL; 95% confidence interval [CI] 93.43-134.69) vs the 47 off statins (127.62 ng/mL; 95% CI, 103.21-152.02). Longitudinal analysis of follow-up data, after adjusting for the phlebotomy treatment effect, showed that statin use was associated with

  12. The Orientation of Gastric Biopsy Samples Improves the Inter-observer Agreement of the OLGA Staging System.

    PubMed

    Cotruta, Bogdan; Gheorghe, Cristian; Iacob, Razvan; Dumbrava, Mona; Radu, Cristina; Bancila, Ion; Becheanu, Gabriel

    2017-12-01

    Evaluation of severity and extension of gastric atrophy and intestinal metaplasia is recommended to identify subjects with a high risk for gastric cancer. The inter-observer agreement for the assessment of gastric atrophy is reported to be low. The aim of the study was to evaluate the inter-observer agreement for the assessment of severity and extension of gastric atrophy using oriented and unoriented gastric biopsy samples. Furthermore, the quality of biopsy specimens in oriented and unoriented samples was analyzed. A total of 35 subjects with dyspeptic symptoms addressed for gastrointestinal endoscopy that agreed to enter the study were prospectively enrolled. The OLGA/OLGIM gastric biopsies protocol was used. From each subject two sets of biopsies were obtained (four from the antrum, two oriented and two unoriented, two from the gastric incisure, one oriented and one unoriented, four from the gastric body, two oriented and two unoriented). The orientation of the biopsy samples was completed using nitrocellulose filters (Endokit®, BioOptica, Milan, Italy). The samples were blindly examined by two experienced pathologists. Inter-observer agreement was evaluated using kappa statistic for inter-rater agreement. The quality of histopathology specimens taking into account the identification of lamina propria was analyzed in oriented vs. unoriented samples. The samples with detectable lamina propria mucosae were defined as good quality specimens. Categorical data was analyzed using chi-square test and a two-sided p value <0.05 was considered statistically significant. A total of 350 biopsy samples were analyzed (175 oriented / 175 unoriented). The kappa index values for oriented/unoriented OLGA 0/I/II/III and IV stages have been 0.62/0.13, 0.70/0.20, 0.61/0.06, 0.62/0.46, and 0.77/0.50, respectively. For OLGIM 0/I/II/III stages the kappa index values for oriented/unoriented samples were 0.83/0.83, 0.88/0.89, 0.70/0.88 and 0.83/1, respectively. No case of OLGIM IV

  13. Introduction to the WSR-88D (NEXRAD) for ornithological research

    Treesearch

    Robert H. Diehl; Ronald P. Larkin

    2005-01-01

    The system of Doppler weather surveillance radars known as WSR-88D or more popularly as NEXRAD helped transform radar ornithology in the United States into a field that today attracts considerable attention from scientists and laypersons alike. As interest in ornithological applications of WSR-88D grows, so does the need to provide perspective on its use. In this paper...

  14. Interrater Agreement in the Radiologic Characterization of Ruptured Intracranial Aneurysms Based on Computed Tomography Angiography.

    PubMed

    Maldaner, Nicolai; Stienen, Martin N; Bijlenga, Philippe; Croci, Davide; Zumofen, Daniel W; Dalonzo, Donato; Marbacher, Serge; Maduri, Rodolfo; Daniel, Roy Thomas; Serra, Carlo; Esposito, Giuseppe; Neidert, Marian Christoph; Bozinov, Oliver; Regli, Luca; Burkhardt, Jan-Karl

    2017-07-01

    To determine interrater agreement in the initial radiologic characterization of ruptured intracranial aneurysms based on computed tomography angiography (CTA) with special emphasis on the rater's level of experience. One junior and one senior rater of 5 high-volume neurovascular tertiary centers evaluated anonymized CTA images of 30 consecutive patients with aneurysmal subarachnoid hemorrhage. Each rater described location, side, size, and morphology in a standardized manner. Interrater variability was analyzed using intraclass correlation and Fleiss' kappa analysis. There was a high level of agreement for location (κ = 0.76, 95% confidence interval [CI] 0.74-0.79), side (κ = 0.95, CI 0.91-0.99), maximum diameter (intraclass correlation coefficient [ICC] 0.81, CI 0.70-0.90), and dome (ICC 0.78, CI 0.66-0.88) of intracranial aneurysms. In contrast, a lower level of agreement was observed for aneurysms' neck diameter (ICC 0.39, CI 0.28-0.58), the presence of multiple aneurysms (κ = 0.35, CI 0.30-0.40), and aneurysm morphology (blister κ = 0.11, CI -0.05 to 0.07; fusiform κ = 0.54, CI 0.48-0.60; multilobular, κ = 0.39 CI 0.33-0.45). The interrater agreement in the senior rater group was greater than in the junior rater group. Interrater agreement confirms the benefit of CTA as initial diagnostic imaging in ruptured intracranial aneurysms but not for aneurysm morphology and presence of multiple aneurysms. A trend towards greater interrater agreement between more experienced raters was noticed. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Comparison of BD Phoenix to Vitek 2, MicroScan MICroSTREP, and Etest for Antimicrobial Susceptibility Testing of Streptococcus pneumoniae▿

    PubMed Central

    Mittman, Scott A.; Huard, Richard C.; Della-Latta, Phyllis; Whittier, Susan

    2009-01-01

    The performance of the BD Phoenix Automated Microbiology System (BD Diagnostic Systems) was compared to those of the Vitek 2 (bioMérieux), the MicroScan MICroSTREP plus (Siemens), and Etest (bioMérieux) for antibiotic susceptibility tests (AST) of 311 clinical isolates of Streptococcus pneumoniae. The overall essential agreement (EA) between each test system and the reference microdilution broth reference method for S. pneumoniae AST results was >95%. For Phoenix, the EAs of individual antimicrobial agents ranged from 90.4% (clindamycin) to 100% (vancomycin and gatifloxacin). The categorical agreements (CA) of Phoenix, Vitek 2, MicroScan, and Etest for penicillin were 95.5%, 94.2%, 98.7%, and 97.7%, respectively. The overall CA for Phoenix was 99.3% (1 very major error [VME] and 29 minor errors [mEs]), that for Vitek 2 was 98.8% (7 VMEs and 28 mEs), and those for MicroScan and Etest were 99.5% each (19 and 13 mEs, respectively). The average times to results for Phoenix, Vitek 2, and the manual methods were 12.1 h, 9.8 h, and 24 h, respectively. From these data, the Phoenix AST results demonstrated a high degree of agreement with all systems evaluated, although fewer VMEs were observed with the Phoenix than with the Vitek 2. Overall, both automated systems provided reliable AST results for the S. pneumoniae-antibiotic combinations in half the time required for the manual methods, rendering them more suitable for the demands of expedited reporting in the clinical setting. PMID:19741088

  16. Exact partition functions for the Ω-deformed {N}={2}^{ast } SU(2) gauge theory

    NASA Astrophysics Data System (ADS)

    Beccaria, Matteo; Macorini, Guido

    2016-07-01

    We study the low energy effective action of the Ω-deformed {N}={2}^{ast } SU(2) gauge theory. It depends on the deformation parameters ɛ 1, ɛ 2, the scalar field expectation value a, and the hypermultiplet mass m. We explore the plane (m/ɛ_1,ɛ_2/ɛ_1) looking for special features in the multi-instanton contributions to the prepotential, motivated by what happens in the Nekrasov-Shatashvili limit ɛ 2 → 0. We propose a simple condition on the structure of poles of the k-instanton prepotential and show that it is admissible at a finite set of points in the above plane. At these special points, the prepotential has poles at fixed positions independent on the instanton number. Besides and remarkably, both the instanton partition function and the full prepotential, including the perturbative contribution, may be given in closed form as functions of the scalar expectation value a and the modular parameter q appearing in special combinations of Eisenstein series and Dedekind η function. As a byproduct, the modular anomaly equation can be tested at all orders at these points. We discuss these special features from the point of view of the AGT correspondence and provide explicit toroidal 1-blocks in non-trivial closed form. The full list of solutions with 1, 2, 3, and 4 poles is determined and described in details.

  17. Agreement between computed tomography, magnetic resonance imaging, and surgical findings in dogs with degenerative lumbosacral stenosis.

    PubMed

    Suwankong, Niyada; Voorhout, George; Hazewinkel, Herman A W; Meij, Björn P

    2006-12-15

    To assess the extent of agreement between computed tomography (CT), magnetic resonance imaging (MRI), and surgical findings in dogs with degenerative lumbosacral stenosis. Observational study. 35 dogs with degenerative lumbosacral stenosis. Results of preoperative CT and MRI were compared with surgical findings with respect to degree and location of disk protrusion, position of the dural sac, amount of epidural fat, and swelling of spinal nerve roots. A lumbosacral step was seen on radiographic images from 22 of 32 (69%) dogs, on CT images from 23 of 35 (66%) dogs, and on MR images from 21 of 35 (60%) dogs. Most dogs had slight or moderate disk protrusion that was centrally located. There was substantial or near perfect agreement between CT and MRI findings in regard to degree of disk protrusion (kappa, 0.88), location of disk protrusion (0.63), position of the dural sac (0.89), amount of epidural fat (0.72), and swelling of spinal nerve roots (0.60). The degree of agreement between CT and surgical findings and between MRI and surgical findings was moderate in regard to degree and location of disk protrusion (kappa, 0.44 to 0.56) and swelling of spinal nerve roots (0.40 and 0.50). Results indicate that there is a high degree of agreement between CT and MRI findings in dogs with degenerative lumbosacral stenosis but that the degree of agreement between diagnostic imaging findings and surgical findings is lower.

  18. Search for the CO-dark Mass in the Central Molecular Zone by using the ASTE 10-m Telescope

    NASA Astrophysics Data System (ADS)

    Tanaka, Kunihiko

    2017-01-01

    Atomic carbon (C0) is one of the most abundant carbon-bearing species in the interstellar molecular gas, and its submillimeter lines are good tracers of low-density molecular clouds which are often dark in CO rotational lines. We present a new map of the central 150 pc region of the Milky Way in the 500 GHz [CI] line, which has been recently obtained with the ASTE 10-m telescope. The [CI] emission is brightest toward the central 5-pc region, where massive GMCs are absent. This [CI]-bright region is approximately centered toward Sgr A*, covering the entire circum-nuclear ring (CND) and the western part of the 50-km/s cloud. The C0/CO abundance ratio is 0.5-2 there, and the highest ratio is observed toward the CND but just outside of the 2-pc ring of dense gas. This discovery may suggest that the CO-dark component occupies a significant fraction of the molecular gas in the circumnuclear region.

  19. Technology Partnership Agreements | NREL

    Science.gov Websites

    Partnership Agreements Technology Partnership Agreements Looking for Funding? We do not fund any projects under a technology partnership agreement. The partner provides the necessary resources and, in using technology partnership agreements. See a summary of our Fiscal Year 2017 technology partnership

  20. 21 CFR 520.88g - Amoxicillin trihydrate and clavulanate potassium film-coated tablets.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Amoxicillin trihydrate and clavulanate potassium film-coated tablets. 520.88g Section 520.88g Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... ANIMAL DRUGS § 520.88g Amoxicillin trihydrate and clavulanate potassium film-coated tablets. (a...

  1. The STS-88 crew and families DEPART for Houston

    NASA Technical Reports Server (NTRS)

    1998-01-01

    STS-88 Commander Robert D. Cabana and his wife, Nancy, enter the airplane that will return them to Houston and the Johnson Space Center. They will be joined by other crew members, with their families, Pilot Frederick W. 'Rick' Sturckow. Mission Specialists Sergei Konstantinovich Krikalev, James H. Newman, Jerry L. Ross and Nancy J. Currie. The STS-88 crew returned Dec. 15 from a 12- day mission on orbit constructing the first elements of the International Space Station, the U.S.-built Unity connecting module and Russian-built Zarya control module.

  2. Discovery of interaction signatures in the Hickson Compact Group 88

    NASA Astrophysics Data System (ADS)

    Brosch, Noah

    2015-08-01

    I describe new observations of the Hickson Compact Group 88 (HCG88) obtained during the commissioning of a new telescope at the Wise Observatory. The observations that reach low surface brightness levels reveal a diffuse, ~20-kpc long low-surface-brightness tail emerging from the brightest component (NGC 6878) to the NW, and possibly a morphological abnormally in component B (NGC 6977). The N6878 tail could explain the asymmetry in this galaxy’s optical rotation curve. These findings show that significant interactions, including possible galactic cannibalism, have taken place in at least two galaxies of this group, contrary to previous claims that HCG88 is in a very early stage of interaction. This work emphasizes the surprisingly interesting results that can be obtained from deep imaging of interesting targets.

  3. 22 CFR 124.6 - Termination of manufacturing license agreements and technical assistance agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... and technical assistance agreements. 124.6 Section 124.6 Foreign Relations DEPARTMENT OF STATE... Termination of manufacturing license agreements and technical assistance agreements. The U.S. party to a manufacturing license or a technical assistance agreement must inform the Directorate of Defense Trade Controls...

  4. 40 CFR 141.88 - Monitoring requirements for lead and copper in source water.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 23 2014-07-01 2014-07-01 false Monitoring requirements for lead and copper in source water. 141.88 Section 141.88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Control of Lead and Copper § 141.88 Monitoring requirements for...

  5. 14 CFR 33.88 - Engine overtemperature test.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Block Tests; Turbine Aircraft Engines § 33.88 Engine overtemperature... this run, the turbine assembly must be within serviceable limits. (b) In addition to the test... this run, the turbine assembly may exhibit distress beyond the limits for an overtemperature condition...

  6. 14 CFR 33.88 - Engine overtemperature test.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Block Tests; Turbine Aircraft Engines § 33.88 Engine overtemperature... this run, the turbine assembly must be within serviceable limits. (b) In addition to the test... this run, the turbine assembly may exhibit distress beyond the limits for an overtemperature condition...

  7. 14 CFR 33.88 - Engine overtemperature test.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Block Tests; Turbine Aircraft Engines § 33.88 Engine overtemperature... this run, the turbine assembly must be within serviceable limits. (b) In addition to the test... this run, the turbine assembly may exhibit distress beyond the limits for an overtemperature condition...

  8. Measuring agreement between cervical vertebrae and hand-wrist maturation in determining skeletal age: reassessing the theory in patients with short stature.

    PubMed

    Danaei, Shahla Momeni; Karamifar, Amirali; Sardarian, Ahmadreza; Shahidi, Shoaleh; Karamifar, Hamdollah; Alipour, Abbas; Ghodsi Boushehri, Sahar

    2014-09-01

    The objective of this study was to determine the degree of agreement between hand-wrist radiography and cervical vertebral maturation analysis in patients diagnosed with short stature. A cross-sectional study was designed; 178 patients (90 girls, 88 boys) diagnosed with short stature and seeking treatment were selected. The patients were divided into 2 groups (76 with familial short stature, 102 with nonfamilial short stature). Hand-wrist and lateral cephalometric radiographs were obtained from the patients. The hand-wrist radiographs were analyzed using the Fishman method, and the lateral cephalometric views were categorized according to the method of Hassel and Farman. The degree of agreement between the 2 methods of predicting skeletal maturation was measured by calculating the contingency coefficient and the weighted kappa statistic. A high degree of agreement was observed between the 2 methods of analyzing skeletal maturation. It was also observed that agreement was higher in girls in the familial short-stature group, whereas boys had higher agreement in the nonfamilial short-stature group. Cervical vertebral maturation can be a valuable substitute for hand-wrist radiography in patients with short stature. Copyright © 2014 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

  9. MyD88 contributes to neuroinflammatory responses induced by cerebral ischemia/reperfusion in mice

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ye, Xinchun; Kong, Delian; Wang, Jun

    Myeloid differentiation primary-response protein-88 (MyD88) is one of adaptor proteins mediating Toll-like receptors (TLRs) signaling. Activation of MyD88 results in the activation of nuclear factor kappa B (NFκB) and the increase of inflammatory responses. Evidences have demonstrated that TLRs signaling contributes to cerebral ischemia/reperfusion (I/R) injury. However, the role of MyD88 in this mechanism of action is disputed and needs to be clarified. In the present study, in a mouse model of cerebral I/R, we examined the activities of NFκB and interferon factor-3 (IRF3), and the inflammatory responses in ischemic brain tissue using ELISA, Western blots, and real-time PCR. Neurologicalmore » function and cerebral infarct size were also evaluated 24 h after cerebral I/R. Our results showed that NFκB activity increased in ischemic brains, but IRF3 was not activated after cerebral I/R, in wild-type (WT) mice. MyD88 deficit inhibited the activation of NFκB, and the expression of interleukin-1β (IL-1β), IL-6, Beclin-1 (BECN1), pellino-1, and cyclooxygenase-2 (COX-2) increased by cerebral I/R compared with WT mice. Interestingly, the expression of interferon Beta 1 (INFB1) and vascular endothelial growth factor (VEGF) increased in MyD88 KO mice. Unexpectedly, although the neurological function improved in the MyD88 knockout (KO) mice, the deficit of MyD88 failed to reduce cerebral infarct size compared to WT mice. We concluded that MyD88-dependent signaling contributes to the inflammatory responses induced by cerebral I/R. MyD88 deficit may inhibit the increased inflammatory response and increase neuroprotective signaling. - Highlights: • Cerebral ischemia/reperfusion activates inflammatory responses in brain tissue. • MyD88-dependent pathway contributes to the activated inflammatory responses. • MyD88 deficit increases neuroprotective signaling in ischemic brain.« less

  10. The Anopheles stephensi odorant binding protein 1 (AsteObp1) gene: a new molecular marker for biological forms diagnosis.

    PubMed

    Gholizadeh, S; Firooziyan, S; Ladonni, H; Hajipirloo, H Mohammadzadeh; Djadid, N Dinparast; Hosseini, A; Raz, A

    2015-06-01

    Anopheles (Cellia) stephensi Liston 1901 is known as an Asian malaria vector. Three biological forms, namely "mysorensis", "intermediate", and "type" have been earlier reported in this species. Nevertheless, the present morphological and molecular information is insufficient to diagnose these forms. During this investigation, An. stephensi biological forms were morphologically identified and sequenced for odorant-binding protein 1 (Obp1) gene. Also, intron I sequences were used to construct phylogenetic trees. Despite nucleotide sequence variation in exon of AsteObp1, nearly 100% identity was observed at the amino acid level among the three biological forms. In order to overcome difficulties in using egg morphology characters, intron I sequences of An. stephensi Obp1 opens new molecular way to the identification of the main Asian malaria vector biological forms. However, multidisciplinary studies are needed to establish the taxonomic status of An. stephensi. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. WSR-88D doppler radar detection of corn earworm moth migration

    USDA-ARS?s Scientific Manuscript database

    Flying insects, birds, and bats contribute to radar reflectivity and radial velocity measured by Doppler weather radars. A study was conducted in the Lower Rio Grande Valley of Texas to determine the capability of Weather Service Radar (version 88D) (WSR-88D) to monitor migratory flights of corn ea...

  12. 48 CFR 1852.216-88 - Performance incentive.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Performance incentive. 1852... 1852.216-88 Performance incentive. As prescribed in 1816.406-70(f), insert the following clause: Performance Incentive (JAN 1997) (a) A performance incentive applies to the following hardware item(s...

  13. 48 CFR 1852.216-88 - Performance incentive.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Performance incentive... 1852.216-88 Performance incentive. As prescribed in 1816.406-70(f), insert the following clause: Performance Incentive (JAN 1997) (a) A performance incentive applies to the following hardware item(s...

  14. 48 CFR 1852.216-88 - Performance incentive.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Performance incentive... 1852.216-88 Performance incentive. As prescribed in 1816.406-70(f), insert the following clause: Performance Incentive (JAN 1997) (a) A performance incentive applies to the following hardware item(s...

  15. Micrometeorological measurements during the Blackmo 88 spray trials

    Treesearch

    D. E. Anderson; D. R. Miller; Y. S. Wang; W. E. Yendol; M. L. McManus

    1991-01-01

    Instrumentation was arrayed on a 120 foot tower to detail the local atmospheric conditions during the Blackmo 88 spray experiment. Measurements were continuous for 30 minute periods encompassing each spray pass.

  16. Computed 88% TCP dose for SBRT of NSCLC from tumour hypoxia modelling

    NASA Astrophysics Data System (ADS)

    Ruggieri, Ruggero; Stavreva, Nadejda; Naccarato, Stefania; Stavrev, Pavel

    2013-07-01

    In small NSCLC, 88% local control at three years from SBRT was reported both for schedule (20-22 Gy ×3) (Fakiris et al 2009 Int. J. Radiat. Oncol. Biol. Phys. 75 677-82), actually close to (18-20 Gy ×3) if density correction is properly applied, and for schedules (18 Gy ×3) and (11 Gy ×5) (Palma et al 2012 Int. J. Radiat. Oncol. Biol. Phys. 82 1149-56). Here, we compare our computed iso-TCP = 88% dose per fraction (d88) for three and five fractions (n) with such clinically adopted ones. Our TCP model accounts for tumour repopulation, at rate λ (d-1), reoxygenation of chronic hypoxia (ch-), at rate a (d-1) and fluctuating oxygenation of acute hypoxia (ah-), with hypoxic fraction (C) of the acutely hypoxic fractional volume (AHF). Out of the eight free parameters whose values we had fitted to in vivo animal data (Ruggieri et al 2012 Int. J. Radiat. Oncol. Biol. Phys. 83 1603-8), we here maintained (a(d-1), C, OERch, OERah/OERch, AHF, CHF) = (0.026, 0.17, 1.9, 2.2, 0.033, 0.145) while rescaling the initial total number of clonogens (No) according to the ratio of NSCLC on animal median tumour volumes. From the clinical literature, the usually assumed (αo/βo(Gy), λ(d-1)) = (10, 0.217) for the well-oxygenated (o-)cells were taken. By normal (lognormal) random sampling of all parameter values over their 95% C.I., the uncertainty on present d88(n) computations was estimated. Finally, SBRT intra-tumour dose heterogeneity was simulated by a 1.3 dose boost ratio on 50% of tumour volume. Computed d88(±1σ) were 19.0 (16.3; 21.7) Gy, for n = 3; 10.4 (8.7; 12.1) Gy, for n = 5; 5.8 (5.2; 6.4) Gy, for n = 8; 4.0 (3.6; 4.3) Gy, for n = 12. Furthermore, the iso-TCP = 88% total dose, D88(n) = d88(n)*n, exhibited a relative minimum around n = 8. Computed d88(n = 3, 5) are strictly consistent with the clinically adopted ones, which confirms the validity of LQ-model-based TCP predictions at the doses used in SBRT if a highly radioresistant cell subpopulation is properly

  17. MyD88-dependent dendritic and epithelial cell crosstalk orchestrates immune responses to allergens.

    PubMed

    Thomas, S Y; Whitehead, G S; Takaku, M; Ward, J M; Xu, X; Nakano, K; Lyons-Cohen, M R; Nakano, H; Gowdy, K M; Wade, P A; Cook, D N

    2018-05-01

    Sensitization to inhaled allergens is dependent on activation of conventional dendritic cells (cDCs) and on the adaptor molecule, MyD88. However, many cell types in the lung express Myd88, and it is unclear how signaling in these different cell types reprograms cDCs and leads to allergic inflammation of the airway. By combining ATAC-seq with RNA profiling, we found that MyD88 signaling in cDCs maintained open chromatin at select loci even at steady state, allowing genes to be rapidly induced during allergic sensitization. A distinct set of genes related to metabolism was indirectly controlled in cDCs through MyD88 signaling in airway epithelial cells (ECs). In mouse models of asthma, Myd88 expression in ECs was critical for eosinophilic inflammation, whereas Myd88 expression in cDCs was required for Th17 cell differentiation and consequent airway neutrophilia. Thus, both cell-intrinsic and cell-extrinsic MyD88 signaling controls gene expression in cDCs and orchestrates immune responses to inhaled allergens.

  18. 49 CFR 585.88 - Petition to extend period to file report.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Petition to extend period to file report. 585.88... Electronic Stability Control System Phase-In Reporting Requirements § 585.88 Petition to extend period to... of the time stated in § 585.86(a). The filing of a petition does not automatically extend the time...

  19. 49 CFR 585.88 - Petition to extend period to file report.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Petition to extend period to file report. 585.88... Electronic Stability Control System Phase-In Reporting Requirements § 585.88 Petition to extend period to... of the time stated in § 585.86(a). The filing of a petition does not automatically extend the time...

  20. 49 CFR 585.88 - Petition to extend period to file report.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Petition to extend period to file report. 585.88... Electronic Stability Control System Phase-In Reporting Requirements § 585.88 Petition to extend period to... of the time stated in § 585.86(a). The filing of a petition does not automatically extend the time...

  1. 49 CFR 585.88 - Petition to extend period to file report.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Petition to extend period to file report. 585.88... Electronic Stability Control System Phase-In Reporting Requirements § 585.88 Petition to extend period to... of the time stated in § 585.86(a). The filing of a petition does not automatically extend the time...

  2. 49 CFR 585.88 - Petition to extend period to file report.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Petition to extend period to file report. 585.88... Electronic Stability Control System Phase-In Reporting Requirements § 585.88 Petition to extend period to... of the time stated in § 585.86(a). The filing of a petition does not automatically extend the time...

  3. Biorecognition of Escherichia coli K88 adhesin for glycated porcine albumin.

    PubMed

    Sarabia-Sainz, Andre-i; Ramos-Clamont, Gabriela; Candia-Plata, Ma María del Carmen; Vázquez-Moreno, Luz

    2009-03-01

    Escherichia coli (E. coli) that expresses galactose-reactive lectins, like K88 adhesin, causes high mortality among piglets. Carbohydrates that compete for adhesion could serve as an alternative for disease prevention. Porcine serum albumin (PSA) was modified by non-enzymatic glycation with lactose to produce PSA-Lac or PSA-Glc beta (1-4) Gal, as confirmed by reduction of available free amino groups, increased molecular mass and by Ricinus communis lectin recognition. E. coli K88 binds to PSA-Lac treatments containing three and four lactoses, respectively. In addition, PSA-Lac partially inhibited K88 strain adherence to mucins. These results suggest that neoglycoconjugates obtained by non-enzymatic glycation of proteins may serve in the prophylaxis of piglets' diarrhea.

  4. 22 CFR 124.8 - Clauses required both in manufacturing license agreements and technical assistance agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... agreements and technical assistance agreements. 124.8 Section 124.8 Foreign Relations DEPARTMENT OF STATE... Clauses required both in manufacturing license agreements and technical assistance agreements. The following statements must be included both in manufacturing license agreements and in technical assistance...

  5. Dendritic cells coordinate innate immunity via MyD88 signaling to control Listeria monocytogenes infection.

    PubMed

    Arnold-Schrauf, Catharina; Dudek, Markus; Dielmann, Anastasia; Pace, Luigia; Swallow, Maxine; Kruse, Friederike; Kühl, Anja A; Holzmann, Bernhard; Berod, Luciana; Sparwasser, Tim

    2014-02-27

    Listeria monocytogenes (LM), a facultative intracellular Gram-positive pathogen, can cause life-threatening infections in humans. In mice, the signaling cascade downstream of the myeloid differentiation factor 88 (MyD88) is essential for proper innate immune activation against LM, as MyD88-deficient mice succumb early to infection. Here, we show that MyD88 signaling in dendritic cells (DCs) is sufficient to mediate the protective innate response, including the production of proinflammatory cytokines, neutrophil infiltration, bacterial clearance, and full protection from lethal infection. We also demonstrate that MyD88 signaling by DCs controls the infection rates of CD8α(+) cDCs and thus limits the spread of LM to the T cell areas. Furthermore, in mice expressing MyD88 in DCs, inflammatory monocytes, which are required for bacterial clearance, are activated independently of intrinsic MyD88 signaling. In conclusion, CD11c(+) conventional DCs critically integrate pathogen-derived signals via MyD88 signaling during early infection with LM in vivo. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  6. Prognostic value of pretreatment serum alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and gamma glutamyltransferase (GGT) in patients with esophageal squamous cell carcinoma.

    PubMed

    Huang, Hao; Wang, Xue-Ping; Li, Xiao-Hui; Chen, Hao; Zheng, Xin; Lin, Jian-Hua; Kang, Ting; Zhang, Lin; Chen, Pei-Song

    2017-08-14

    The levels of liver function tests (LFTs) are often used to assess liver injury and non-liver disease-related mortality. In our study, the relationship between pretreatment serum LFTs and overall survival (OS) was evaluated in esophageal squamous cell carcinoma (ESCC) patients. Our purpose was to investigate the prognostic value of the preoperative alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and gamma glutamyltransferase (GGT) in ESCC patients. A retrospective study was performed in 447 patients with ESCC, and follow-up period was at least 60 months until death. The prognostic significance of serum LFTs were determined by univariate and multivariate Cox hazard models. LFTs including ALT, AST, LSR, GGT, TBA and LDH were analyzed. Serum LSR (HR: 0.592, 95% CI = 0.457-0.768, p < 0.001 and GGT (HR: 1.507, 95% CI = 1.163-1.953, p = 0.002) levels were indicated as significant predictors of OS. The 5-year OS among patients with higher LSR levels was longer compared with those patients with decreased LSR levels, not only in the whole cohort but also in the subgroups stratified by pathological stage (T1-T2 subgroup, T3-T4 subgroup, N0 subgroup and M0 subgroup). We also found that patients with a higher GGT might predict worse OS than patients with a normal GGT, not only in the whole cohort but also in the subgroups stratified by pathological stage (T3-T4 subgroup and N1-N2 subgroup). Both increased levels of LSR and decreased levels of GGT might predict shorter overall survival in ESCC patients. Our findings suggest that serum LSR and GGT levels could be used as a key predictor of survival in patients with ESCC.

  7. Nondisclosure Agreements | NREL

    Science.gov Websites

    the agreement. 5. Share Information and Maintain Records Once the nondisclosure agreement has been executed, appropriately labeled information may be shared. NREL and the other party then maintain records

  8. Measurement of the low-energy quenching factor in germanium using an Y 88 / Be photoneutron source

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Scholz, B. J.; Chavarria, A. E.; Collar, J. I.

    2016-12-01

    We employ an 88Y/Be photoneutron source to derive the quenching factor for neutron-induced nuclear recoils in germanium, probing recoil energies from a few hundred eVnr to 8.5 keV nr. A comprehensive Monte Carlo simulation of our setup is compared to experimental data employing a Lindhard model with a free electronic energy loss k and an adiabatic correction for sub-keVnr nuclear recoils. The best fit k=0.179±0.001 obtained using a Monte Carlo Markov chain (MCMC) ensemble sampler is in good agreement with previous measurements, confirming the adequacy of the Lindhard model to describe the stopping of few-keV ions in germanium crystals at a temperaturemore » of ~77 K. This value of k corresponds to a quenching factor of 13.7% to 25.3% for nuclear recoil energies between 0.3 and 8.5 keV nr, respectively.« less

  9. MALDI Imaging Analysis of Neuropeptides in Africanized Honeybee (Apis mellifera) Brain: Effect of Aggressiveness.

    PubMed

    Pratavieira, Marcel; Menegasso, Anally Ribeiro da Silva; Esteves, Franciele Grego; Sato, Kenny Umino; Malaspina, Osmar; Palma, Mario Sérgio

    2018-05-18

    The aggressiveness in honeybees seems to be regulated by multiple genes, under the influence of different factors, such as polyethism of workers, environmental factors, and response to alarm pheromones, creating a series of behavioral responses. It is suspected that neuropeptides seem to be involved with the regulation of the aggressive behavior. The role of allatostatin and tachykinin-related neuropeptides in honeybee brain during the aggressive behavior is unknown; thus, worker honeybees were stimulated to attack and to sting leather targets hanged in front of the colonies. The aggressive individuals were collected and immediately frozen in liquid nitrogen; the heads were removed, and sliced at sagittal plan. The brain slices were submitted to MALDI-Spectral-Imaging analysis, and the results of the present study reported the processing of the precursors proteins into mature forms of the neuropeptides AmAST A (59-76) (AYTYVSEYKRLPVYNFGL-NH2), AmAST A (69-76) (LPVYNFGL-NH2), AmTRP (88 - 96) (APMGFQGMR-NH2), and AmTRP (254 - 262) (ARMGFHGMR-NH2), which apparently acted in different neuropils of honeybee brain, during the aggressive behavior, possibly playing the neuromodulation of different aspects of this complex behavior. These results were biologically validated performing aggressiveness-related behavioral assays, using young honeybee workers that received 1 ng of AmAST A (69-76) or AmTRP (88 - 96) via hemocele. The young workers that were not expected to be aggressive individuals, presented a complete series of the aggressive behaviors, in presence of the neuropeptides, corroborating the hypothesis that correlates the presence of mature AmASTs A and AmTRPs in honeybee brain with the aggressiveness of this insect.

  10. STS-88 Mission Specialists Currie and Ross inside Endeavour

    NASA Technical Reports Server (NTRS)

    1998-01-01

    STS-88 Mission Specialists Nancy J. Currie, Ph.D., (back) and Jerry L. Ross (front) check over equipment inside orbiter Endeavour during Terminal Countdown Demonstration Activities (TCDT). The TCDT includes mission familiarization activities, emergency egress training, and the simulated main engine cut-off exercise. Mission STS-88 is targeted for launch on Dec. 3, 1998. It is the first U.S. flight for the assembly of the International Space Station and will carry the Unity connecting module. Unity will be mated with the already orbiting Russian-built Zarya control module. The 12-day mission includes three planned spacewalks to connect power, data and utility lines and install exterior equipment.

  11. 12 CFR 1291.9 - Agreements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Agreements. 1291.9 Section 1291.9 Banks and... HOUSING PROGRAM § 1291.9 Agreements. (a) Agreements between Banks and members. A Bank shall have in place with each member receiving an AHP subsidized advance or AHP direct subsidy an agreement or agreements...

  12. 12 CFR 1291.9 - Agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Agreements. 1291.9 Section 1291.9 Banks and... HOUSING PROGRAM § 1291.9 Agreements. (a) Agreements between Banks and members. A Bank shall have in place with each member receiving an AHP subsidized advance or AHP direct subsidy an agreement or agreements...

  13. 12 CFR 1291.9 - Agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Agreements. 1291.9 Section 1291.9 Banks and... HOUSING PROGRAM § 1291.9 Agreements. (a) Agreements between Banks and members. A Bank shall have in place with each member receiving an AHP subsidized advance or AHP direct subsidy an agreement or agreements...

  14. 12 CFR 1291.9 - Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Agreements. 1291.9 Section 1291.9 Banks and... HOUSING PROGRAM § 1291.9 Agreements. (a) Agreements between Banks and members. A Bank shall have in place with each member receiving an AHP subsidized advance or AHP direct subsidy an agreement or agreements...

  15. 12 CFR 1291.9 - Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Agreements. 1291.9 Section 1291.9 Banks and... HOUSING PROGRAM § 1291.9 Agreements. (a) Agreements between Banks and members. A Bank shall have in place with each member receiving an AHP subsidized advance or AHP direct subsidy an agreement or agreements...

  16. WSR-88D observations of volcanic ash

    USGS Publications Warehouse

    Wood, J.; Scott, C.; Schneider, D.

    2007-01-01

    Conclusions that may impact operations are summarized below: ??? Current VCPs may not be optimal for the scharacterization of volcanic events. Therefore, the development of a new VCP that combines the enhanced low level elevation density and increased temporal resolution of VCP 12 with the enhanced sensitivity of VCP 31. ??? Given currently available scan strategies, this preliminary investigation would suggest that it is advisable to use VCP 12 during the initial explosive phase of an eruptive event. Once the maximum reflectivity has dropped below 30 dBZ, VCP 31 should be used. ??? This study clearly indicates that WSR-88D Level II data offers many advantages over Level III data currently available in Alaska. The ability to access this data would open up greater opportunities for research. Given the proximity of WSR-88D platforms to active volcanoes in Alaska, as well as in the western Lower 48 states and Hawaii, radar data will likely play a major operational role when volcanic eruptions again pose a threat to life and property. The utilization of this tool to its maximum capability is vital.

  17. Naval Health Research Center Command Annual Report Calendar Year 1987 and FY-88

    DTIC Science & Technology

    1988-01-01

    1044-1055). Conference Proceedings Space 󈨜, 29-31 Aug 88, Albuquerque, New Mexico . 1988, New York: American Society of Civil Engineers. (Center...Proceedings Space 󈨜, 29-31 Aug 88, Albuquerque, New Mexico . 1988, New York: American Society of Civil Engineers. Work Unit: Army 3MI62770.A87@.AR...New Mexico , 29-31 Aug 88 Dr. Palinkas - "The Human Experience in Space: Lessons from Antarctica" Association of Professional Sleep Societies Meetings

  18. Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88.

    PubMed

    Into, Takeshi; Horie, Toshi; Inomata, Megumi; Gohda, Jin; Inoue, Jun-Ichiro; Murakami, Yukitaka; Niida, Shumpei

    2017-04-21

    Autophagy, the processes of delivery of intracellular components to lysosomes, regulates induction of inflammation. Inducible macroautophagy degrades inflammasomes and dysfunctional mitochondria to downregulate inflammatory signals. Nonetheless, the effects of constitutive basal autophagy on inflammatory signals are largely unknown. Here, we report a previously unknown effect of basal autophagy. Lysosomal inhibition induced weak inflammatory signals in the absence of a cellular stimulus and in the presence of a nutrient supply, and their induction was impaired by MyD88 deficiency. During lysosomal inhibition, MyD88 was accumulated, and overabundant MyD88 autoactivated downstream signaling or enhanced TLR/IL-1R-mediated signaling. MyD88 is probably degraded via basal microautophagy because macroautophagy inhibitors, ATG5 deficiency, and an activator of chaperone-mediated autophagy did not affect MyD88. Analysis using a chimeric protein whose monomerization/dimerization can be switched revealed that monomeric MyD88 is susceptible to degradation. Immunoprecipitation of monomeric MyD88 revealed its interaction with TRAF6. In TRAF6-deficient cells, degradation of basal MyD88 was enhanced, suggesting that TRAF6 participates in protection from basal autophagy. Thus, basal autophagy lowers monomeric MyD88 expression, and thereby autoactivation of inflammatory signals is prevented. Given that impairment of lysosomes occurs in various settings, our results provide novel insights into the etiology of inflammatory signals that affect consequences of inflammation.

  19. Surrogate Agreement in Tzotzil.

    ERIC Educational Resources Information Center

    Aissen, Judith L.

    This study investigates whether other relationships in sentence structure besides the "brother-in-law" relation sanction surrogate agreement in Zinacanteco Tzotzil (Mayan). Surrogate agreement refers to cases in which an element that lies outside the class of regular agreement controllers in a language (the surrogate) controls…

  20. Placido disk-based topography versus high-resolution rotating Scheimpflug camera for corneal power measurements in keratoconic and post-LASIK eyes: reliability and agreement.

    PubMed

    Penna, Rachele R; de Sanctis, Ugo; Catalano, Martina; Brusasco, Luca; Grignolo, Federico M

    2017-01-01

    To compare the repeatability/reproducibility of measurement by high-resolution Placido disk-based topography with that of a high-resolution rotating Scheimpflug camera and assess the agreement between the two instruments in measuring corneal power in eyes with keratoconus and post-laser in situ keratomileusis (LASIK). One eye each of 36 keratoconic patients and 20 subjects who had undergone LASIK was included in this prospective observational study. Two independent examiners worked in a random order to take three measurements of each eye with both instruments. Four parameters were measured on the anterior cornea: steep keratometry (Ks), flat keratometry (Kf), mean keratometry (Km), and astigmatism (Ks-Kf). Intra-examiner repeatability and inter-examiner reproducibility were evaluated by calculating the within-subject standard deviation (Sw) the coefficient of repeatability (R), the coefficient of variation (CoV), and the intraclass correlation coefficient (ICC). Agreement between instruments was tested with the Bland-Altman method by calculating the 95% limits of agreement (95% LoA). In keratoconic eyes, the intra-examiner and inter-examiner ICC were >0.95. As compared with measurement by high-resolution Placido disk-based topography, the intra-examiner R of the high-resolution rotating Scheimpflug camera was lower for Kf (0.32 vs 0.88), Ks (0.61 vs 0.88), and Km (0.32 vs 0.84) but higher for Ks-Kf (0.70 vs 0.57). Inter-examiner R values were lower for all parameters measured using the high-resolution rotating Scheimpflug camera. The 95% LoA were -1.28 to +0.55 for Kf, -1.36 to +0.99 for Ks, -1.08 to +0.50 for Km, and -1.11 to +1.48 for Ks-Kf. In the post-LASIK eyes, the intra-examiner and inter-examiner ICC were >0.87 for all parameters. The intra-examiner and inter-examiner R were lower for all parameters measured using the high-resolution rotating Scheimpflug camera. The intra-examiner R was 0.17 vs 0.88 for Kf, 0.21 vs 0.88 for Ks, 0.17 vs 0.86 for Km, and 0

  1. Placido disk-based topography versus high-resolution rotating Scheimpflug camera for corneal power measurements in keratoconic and post-LASIK eyes: reliability and agreement

    PubMed Central

    Penna, Rachele R.; de Sanctis, Ugo; Catalano, Martina; Brusasco, Luca; Grignolo, Federico M.

    2017-01-01

    AIM To compare the repeatability/reproducibility of measurement by high-resolution Placido disk-based topography with that of a high-resolution rotating Scheimpflug camera and assess the agreement between the two instruments in measuring corneal power in eyes with keratoconus and post-laser in situ keratomileusis (LASIK). METHODS One eye each of 36 keratoconic patients and 20 subjects who had undergone LASIK was included in this prospective observational study. Two independent examiners worked in a random order to take three measurements of each eye with both instruments. Four parameters were measured on the anterior cornea: steep keratometry (Ks), flat keratometry (Kf), mean keratometry (Km), and astigmatism (Ks-Kf). Intra-examiner repeatability and inter-examiner reproducibility were evaluated by calculating the within-subject standard deviation (Sw) the coefficient of repeatability (R), the coefficient of variation (CoV), and the intraclass correlation coefficient (ICC). Agreement between instruments was tested with the Bland-Altman method by calculating the 95% limits of agreement (95% LoA). RESULTS In keratoconic eyes, the intra-examiner and inter-examiner ICC were >0.95. As compared with measurement by high-resolution Placido disk-based topography, the intra-examiner R of the high-resolution rotating Scheimpflug camera was lower for Kf (0.32 vs 0.88), Ks (0.61 vs 0.88), and Km (0.32 vs 0.84) but higher for Ks-Kf (0.70 vs 0.57). Inter-examiner R values were lower for all parameters measured using the high-resolution rotating Scheimpflug camera. The 95% LoA were -1.28 to +0.55 for Kf, -1.36 to +0.99 for Ks, -1.08 to +0.50 for Km, and -1.11 to +1.48 for Ks-Kf. In the post-LASIK eyes, the intra-examiner and inter-examiner ICC were >0.87 for all parameters. The intra-examiner and inter-examiner R were lower for all parameters measured using the high-resolution rotating Scheimpflug camera. The intra-examiner R was 0.17 vs 0.88 for Kf, 0.21 vs 0.88 for Ks, 0.17 vs 0

  2. STS-88 Crew Breakfast in O&C Building

    NASA Technical Reports Server (NTRS)

    1998-01-01

    The STS-88 crew gather for the traditional pre-launch breakfast in the Operations and Checkout Building. From left to right are Mission Specialists Jerry L. Ross and Nancy J. Currie, Commander Robert D. Cabana, Pilot Frederick W. 'Rick' Sturckow, and Mission Specialists James H. Newman and Sergei Konstantinovich Krikalev, a Russian cosmonaut. Mission STS-88 is expected to launch at 3:56 a.m. EST aboard Space Shuttle Endeavour on Dec. 3. Endeavour carries the Unity connecting module, which the crew will be mating with the Russian-built Zarya control module already on orbit. In addition to Unity, two small replacement electronics boxes are on board for possible repairs to Zarya batteries. The mission is expected to last 11 days, 19 hours and 49 minutes, landing at 10:17 p.m. EST on Dec. 14.

  3. MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus.

    PubMed

    Reynolds, Lisa A; Harcus, Yvonne; Smith, Katherine A; Webb, Lauren M; Hewitson, James P; Ross, Ewan A; Brown, Sheila; Uematsu, Satoshi; Akira, Shizuo; Gray, David; Gray, Mohini; MacDonald, Andrew S; Cunningham, Adam F; Maizels, Rick M

    2014-09-15

    Helminth parasites remain one of the most common causes of infections worldwide, yet little is still known about the immune signaling pathways that control their expulsion. C57BL/6 mice are chronically susceptible to infection with the gastrointestinal helminth parasite Heligmosomoides polygyrus. In this article, we report that C57BL/6 mice lacking the adapter protein MyD88, which mediates signaling by TLRs and IL-1 family members, showed enhanced immunity to H. polygyrus infection. Alongside increased parasite expulsion, MyD88-deficient mice showed heightened IL-4 and IL-17A production from mesenteric lymph node CD4(+) cells. In addition, MyD88(-/-) mice developed substantial numbers of intestinal granulomas around the site of infection, which were not seen in MyD88-sufficient C57BL/6 mice, nor when signaling through the adapter protein TRIF (TIR domain-containing adapter-inducing IFN-β adapter protein) was also ablated. Mice deficient solely in TLR2, TLR4, TLR5, or TLR9 did not show enhanced parasite expulsion, suggesting that these TLRs signal redundantly to maintain H. polygyrus susceptibility in wild-type mice. To further investigate signaling pathways that are MyD88 dependent, we infected IL-1R1(-/-) mice with H. polygyrus. This genotype displayed heightened granuloma numbers compared with wild-type mice, but without increased parasite expulsion. Thus, the IL-1R-MyD88 pathway is implicated in inhibiting granuloma formation; however, protective immunity in MyD88-deficient mice appears to be granuloma independent. Like IL-1R1(-/-) and MyD88(-/-) mice, animals lacking signaling through the type 1 IFN receptor (i.e., IFNAR1(-/-)) also developed intestinal granulomas. Hence, IL-1R1, MyD88, and type 1 IFN receptor signaling may provide pathways to impede granuloma formation in vivo, but additional MyD88-mediated signals are associated with inhibition of protective immunity in susceptible C57BL/6 mice. Copyright © 2014 The Authors.

  4. Agreement between self-reported sleep patterns and actigraphy in fibromyalgia and healthy women.

    PubMed

    Segura-Jiménez, Víctor; Camiletti-Moirón, Daniel; Munguía-Izquierdo, Diego; Álvarez-Gallardo, Inmaculada C; Ruiz, Jonatan R; Ortega, Francisco B; Delgado-Fernández, Manuel

    2015-01-01

    To examine the agreement between objective (accelerometer) and subjective measures of sleep in fibromyalgia women (FW) and healthy women (HW). To identify explanatory variables of the discrepancies between the objective and subjective measures in FW and in HW. 127 diagnosed FW and 53 HW filled the Fibromyalgia Impact Questionnaire (FIQ) and wore the SenseWear Pro Armband (SWA) for 7 days in order to assess sleep over the last week. Participants completed the Pittsburgh Sleep Quality Index (PSQI) when the SWA was returned. The SWA showed greater total duration (74 vs. 88 min/day) and average duration (7 vs. 9 min) of wake after sleep onset in FW compared with HW. The PSQI showed poorer sleep quality in all the variables studied in FW than in HW (all, p<0.001), except time in bed. There was a lack of inter-method agreement for total sleep time, sleep time without naps and sleep latency in FW. Age and educational status explained the inter-method mean difference in sleep time in FW. High discrepancy in sleep time between the SWA and the PSQI was related to higher FIQ scores (p<0.05). The objective measure only showed higher frequency and average duration of wake after sleep onset in FW compared with HW. The agreement between the SWA and the PSQI measures of sleep were poor in the FW group. Age, educational level and the impact of fibromyalgia might be explanatory variables of the inter-method discrepancies in FW.

  5. Summary of the Blackmo 88 spray experiment

    Treesearch

    D. R. Miller; W. E. Yendol; M. L. McManus; D. E. Anderson; K. Mierzejewski

    1991-01-01

    The Blackmo 88 spray trial experiment was conducted for two primary purposes: To quantify the effects of local micrometeorological processes, in and near the canopy, on the deposition patterns of aerially applied BT in a mature oak forest; To generate a data set containing simultaneous measurements of spray deposition and detailed micrometeorology, in a canopy of known...

  6. Sandia National Laboratories: Agreements

    Science.gov Websites

    Technology Partnerships Business, Industry, & Non-Profits Government Universities Center for Development Agreement (CRADA) Strategic Partnership Projects, Non-Federal Entity (SPP/NFE) Agreements New Projects, Non-Federal Entity (SPP/NFE) Agreements Sandia performs work on a reimbursable basis for a non

  7. Bromelain protects piglets from diarrhoea caused by oral challenge with K88 positive enterotoxigenic Escherichia coli

    PubMed Central

    Chandler, D; Mynott, T

    1998-01-01

    Background—K88 positive enterotoxigenic Escherichia coli (K88+ ETEC) is an important cause of diarrhoea in young piglets. K88+ ETEC pathogenesis relies on attachment to specific glycoprotein receptors located on the intestinal mucosa. Proteolytic treatment of these receptors in vitro and in vivo prevents attachment of K88+ ETEC to piglet small intestines and may be of clinical use to prevent K88+ ETEC pathogenesis. 
Aims—To determine whether bromelain, a proteolytic extract obtained from pineapple stems, would protect piglets against K88+ ETEC diarrhoea and to confirm and extend earlier findings on the effects of bromelain on K88+ ETEC receptors in vivo. 
Methods—Bromelain (0, 12.5, or 125 mg) was orally administered to just weaned piglets for 10 days. One day following commencement of bromelain treatment, piglets were challenged with K88+ ETEC (5 × 1010 K88ac:0149) for seven days. Intestinal contents from unchallenged piglets were obtained via an intestinal fistula, and tested for their ability to bind K88+ ETEC before and after bromelain treatment. 
Results—Both doses of bromelain were successful in reducing the incidence of K88+ ETEC diarrhoea and protected piglets from life threatening disease. Bromelain treated pigs also had significantly increased weight gain compared with untreated pigs. Bromelain only temporarily inhibited K88+ ETEC receptor activity, with receptor activity being regenerated 30 hours following treatment, consistent with the regeneration of new enterocytes. 
Conclusion—Results show that bromelain can temporarily inactivate ETEC receptors in vivo and protect against ETEC induced diarrhoea. Bromelain may therefore be an effective prophylaxis against ETEC infection. 

 Keywords: enterotoxigenic Escherichia coli; K88 ETEC; ETEC receptors; diarrhoea; bromelain PMID:10189844

  8. STS-88 Day 01 Highlights

    NASA Technical Reports Server (NTRS)

    1998-01-01

    On this first day of the STS-88 mission, the flight crew, Commander Robert D. Cabana, Pilot Frederick W. Sturckow, and Mission Specialists Nancy J. Currie, James H. Newman, Jerry L. Ross, and Sergei Krikalev can be seen performing pre-launch activities such as eating the traditional breakfast, crew suit-up, and the ride out to the launch pad. Also, included are various panoramic views of the shuttle on the pad. The crew is readied in the "white room" for their mission. After the closing of the hatch and arm retraction, launch activities are shown including countdown, engine ignition, launch, and the separation of the Solid Rocket Boosters.

  9. STS-88 crew members take part in news conference

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Introduced by NASA News Chief Bruce Buckingham (left), the STS-88 crew answer questions from media representatives after a day of Terminal Countdown Demonstration Test (TCDT) activities. From left, they are Mission Commander Robert D. Cabana, Pilot Frederick W. 'Rick' Sturckow, and Mission Specialists Jerry L. Ross, Nancy J. Currie, James H. Newman and Sergei Konstantinovich Krikalev, a Russian cosmonaut. The TCDT provides the crew with simulated countdown exercises, emergency egress training, and opportunities to inspect their mission payloads in the orbiter's payload bay. STS-88 is targeted for launch on Dec. 3, 1998. It is the first U.S. flight for the assembly of the International Space Station and will carry the Unity connecting module.

  10. Adaptive Self Tuning

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Peterson, Matthew; Draelos, Timothy; Knox, Hunter

    2017-05-02

    The AST software includes numeric methods to 1) adjust STA/LTA signal detector trigger level (TL) values and 2) filter detections for a network of sensors. AST adapts TL values to the current state of the environment by leveraging cooperation within a neighborhood of sensors. The key metric that guides the dynamic tuning is consistency of each sensor with its nearest neighbors: TL values are automatically adjusted on a per station basis to be more or less sensitive to produce consistent agreement of detections in its neighborhood. The AST algorithm adapts in near real-time to changing conditions in an attempt tomore » automatically self-tune a signal detector to identify (detect) only signals from events of interest.« less

  11. A juridical review of partnership agreements that have the elements of work agreements in Indonesia

    NASA Astrophysics Data System (ADS)

    Nugroho, A.; Sulistyowati, E.; Hikmah, N.

    2018-01-01

    The Partnership Agreements place the parties in an equal position each party has something as the bargaining power. In some cases, employers prefer to use Partnership Agreements to some individuals to complete the work in their company than Work agreements. Practicality and the absence of obligations to fulfil workers’ rights such as the right to join a Union and to get social security are some of the reasons why employers use the Partnership Agreements. Sometimes Partnership Agreement contains jobs, wages and orders which is the characteristic of work agreement. Based on the fact above, the legal issues arise whether the Partnership Agreement can be considered as the Work Agreement or not and which court is authorized to hear in the event of a dispute. To analyze the above legal issues, this research uses normative legal research type with the statute approach. The technique of legal material analysis uses prescriptive techniques to assess the issue and make recommendations. Based on the analysis, it can be concluded that the Partnership Agreement, of which the elements are: wages and orders can be categorized as Work Agreement and therefore in the event of a dispute, the authorized court is Industrial Relations Court.

  12. Validation of Vitek 2 Nonfermenting Gram-Negative Cards and Vitek 2 Version 4.02 Software for Identification and Antimicrobial Susceptibility Testing of Nonfermenting Gram-Negative Rods from Patients with Cystic Fibrosis▿

    PubMed Central

    Otto-Karg, Ines; Jandl, Stefanie; Müller, Tobias; Stirzel, Beate; Frosch, Matthias; Hebestreit, Helge; Abele-Horn, Marianne

    2009-01-01

    Accurate identification and antimicrobial susceptibility testing (AST) of nonfermenters from cystic fibrosis patients are essential for appropriate antimicrobial treatment. This study examined the ability of the newly designed Vitek 2 nonfermenting gram-negative card (NGNC) (new gram-negative identification card; bioMérieux, Marcy-l'Ètoile, France) to identify nonfermenting gram-negative rods from cystic fibrosis patients in comparison to reference methods and the accuracy of the new Vitek 2 version 4.02 software for AST compared to the broth microdilution method. Two hundred twenty-four strains for identification and 138 strains for AST were investigated. The Vitek 2 NGNC identified 211 (94.1%) of the nonfermenters correctly. Among morphologically atypical microorganisms, five strains were misidentified and eight strains were determined with low discrimination, requiring additional tests which raised the correct identification rate to 97.8%. Regarding AST, the overall essential agreement of Vitek 2 was 97.6%, and the overall categorical agreement was 92.9%. Minor errors were found in 5.1% of strains, and major and very major errors were found in 1.6% and 0.3% of strains, respectively. In conclusion, the Vitek NGNC appears to be a reliable method for identification of morphologically typical nonfermenters and is an improvement over the API NE system and the Vitek 2 GNC database version 4.01. However, classification in morphologically atypical nonfermenters must be interpreted with care to avoid misidentification. Moreover, the new Vitek 2 version 4.02 software showed good results for AST and is suitable for routine clinical use. More work is needed for the reliable testing of strains whose MICs are close to the breakpoints. PMID:19710272

  13. Multicenter Evaluation of the Accelerate PhenoTest BC Kit for Rapid Identification and Phenotypic Antimicrobial Susceptibility Testing Using Morphokinetic Cellular Analysis

    PubMed Central

    2018-01-01

    ABSTRACT We describe results from a multicenter study evaluating the Accelerate Pheno system, a first of its kind diagnostic system that rapidly identifies common bloodstream pathogens from positive blood cultures within 90 min and determines bacterial phenotypic antimicrobial susceptibility testing (AST) results within ∼7 h. A combination of fresh clinical and seeded blood cultures were tested, and results from the Accelerate Pheno system were compared to Vitek 2 results for identification (ID) and broth microdilution or disk diffusion for AST. The Accelerate Pheno system accurately identified 14 common bacterial pathogens and two Candida spp. with sensitivities ranging from 94.6 to 100%. Of fresh positive blood cultures, 89% received a monomicrobial call with a positive predictive value of 97.3%. Six common Gram-positive cocci were evaluated for ID. Five were tested against eight antibiotics, two resistance phenotypes (methicillin-resistant Staphylococcus aureus and Staphylococcus spp. [MRSA/MRS]), and inducible clindamycin resistance (MLSb). From the 4,142 AST results, the overall essential agreement (EA) and categorical agreement (CA) were 97.6% and 97.9%, respectively. Overall very major error (VME), major error (ME), and minor error (mE) rates were 1.0%, 0.7%, and 1.3%, respectively. Eight species of Gram-negative rods were evaluated against 15 antibiotics. From the 6,331 AST results, overall EA and CA were 95.4% and 94.3%, respectively. Overall VME, ME, and mE rates were 0.5%, 0.9%, and 4.8%, respectively. The Accelerate Pheno system has the unique ability to identify and provide phenotypic MIC and categorical AST results in a few hours directly from positive blood culture bottles and support accurate antimicrobial adjustment. PMID:29305546

  14. 9 CFR 3.88 - Primary conveyances (motor vehicle, rail, air, and marine).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Primary conveyances (motor vehicle, rail, air, and marine). 3.88 Section 3.88 Animals and Animal Products ANIMAL AND PLANT HEALTH... conveyances (motor vehicle, rail, air, and marine). (a) The animal cargo space of primary conveyances used to...

  15. 9 CFR 3.88 - Primary conveyances (motor vehicle, rail, air, and marine).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Primary conveyances (motor vehicle, rail, air, and marine). 3.88 Section 3.88 Animals and Animal Products ANIMAL AND PLANT HEALTH... conveyances (motor vehicle, rail, air, and marine). (a) The animal cargo space of primary conveyances used to...

  16. 9 CFR 3.88 - Primary conveyances (motor vehicle, rail, air, and marine).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Primary conveyances (motor vehicle, rail, air, and marine). 3.88 Section 3.88 Animals and Animal Products ANIMAL AND PLANT HEALTH... conveyances (motor vehicle, rail, air, and marine). (a) The animal cargo space of primary conveyances used to...

  17. 9 CFR 3.88 - Primary conveyances (motor vehicle, rail, air, and marine).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Primary conveyances (motor vehicle, rail, air, and marine). 3.88 Section 3.88 Animals and Animal Products ANIMAL AND PLANT HEALTH... conveyances (motor vehicle, rail, air, and marine). (a) The animal cargo space of primary conveyances used to...

  18. 9 CFR 3.88 - Primary conveyances (motor vehicle, rail, air, and marine).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Primary conveyances (motor vehicle, rail, air, and marine). 3.88 Section 3.88 Animals and Animal Products ANIMAL AND PLANT HEALTH... conveyances (motor vehicle, rail, air, and marine). (a) The animal cargo space of primary conveyances used to...

  19. 49 CFR 212.105 - Agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Agreements. 212.105 Section 212.105 Transportation... TRANSPORTATION STATE SAFETY PARTICIPATION REGULATIONS State/Federal Roles § 212.105 Agreements. (a) Scope. The... agreement with FRA. An agreement may delegate investigative and surveillance authority with respect to all...

  20. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Agreements. 247.4 Section 247.4 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are necessary for agencies to administer CSFP? The following agreements are necessary for agencies to administer...

  1. 49 CFR 212.105 - Agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Agreements. 212.105 Section 212.105 Transportation... TRANSPORTATION STATE SAFETY PARTICIPATION REGULATIONS State/Federal Roles § 212.105 Agreements. (a) Scope. The... agreement with FRA. An agreement may delegate investigative and surveillance authority with respect to all...

  2. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Agreements. 247.4 Section 247.4 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are necessary for agencies to administer CSFP? The following agreements are necessary for agencies to administer...

  3. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Agreements. 247.4 Section 247.4 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are necessary for agencies to administer CSFP? The following agreements are necessary for agencies to administer...

  4. 49 CFR 212.105 - Agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Agreements. 212.105 Section 212.105 Transportation... TRANSPORTATION STATE SAFETY PARTICIPATION REGULATIONS State/Federal Roles § 212.105 Agreements. (a) Scope. The... agreement with FRA. An agreement may delegate investigative and surveillance authority with respect to all...

  5. 49 CFR 212.105 - Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Agreements. 212.105 Section 212.105 Transportation... TRANSPORTATION STATE SAFETY PARTICIPATION REGULATIONS State/Federal Roles § 212.105 Agreements. (a) Scope. The... agreement with FRA. An agreement may delegate investigative and surveillance authority with respect to all...

  6. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Agreements. 247.4 Section 247.4 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are necessary for agencies to administer CSFP? The following agreements are necessary for agencies to administer...

  7. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Agreements. 247.4 Section 247.4 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are necessary for agencies to administer CSFP? The following agreements are necessary for agencies to administer...

  8. 49 CFR 212.105 - Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Agreements. 212.105 Section 212.105 Transportation... TRANSPORTATION STATE SAFETY PARTICIPATION REGULATIONS State/Federal Roles § 212.105 Agreements. (a) Scope. The... agreement with FRA. An agreement may delegate investigative and surveillance authority with respect to all...

  9. Intra- and inter-observer agreement when using a descriptive classification scale for clinical assessment of faecal consistency in growing pigs.

    PubMed

    Pedersen, Ken Steen; Toft, Nils

    2011-03-01

    The objective of the current study was to evaluate intra- and inter-observer agreement using a descriptive classification scale with four categories, descriptive text and pictures for assessment of consistency in faecal samples from pigs post weaning. The four consistency categories were score one=firm and shaped, score two=soft and shaped, score three=loose and score four=watery. Five observers from the same veterinary practice examined 100 faecal samples using the scale with four categories. Four of the observers examined the 100 faecal samples twice within the same day. Within observers the difference in proportions for the individual consistency categories between two examinations was on average 0.04 (range: 0-0.10). The mean intra-observer agreement was 0.82 (range: 0.72-0.91) with a mean kappa value of 0.76 (range: 0.61-0.88). For inter-observer agreement overall kappa was 0.64. For the 10 pair-wise comparisons the mean inter-observer agreement was 0.73 (range: 0.61-0.90) with a mean kappa value of 0.64 (range: 0.48-0.87). The difference in proportions for the individual consistency categories was on average 0.08 (range: 0-0.17). In conclusion, the agreement observed for the descriptive classification scale with four categories, descriptive text and pictures may be categorized as a substantial to almost perfect intra-observer agreement and a moderate to almost perfect inter-observer agreement. However, more objective measures than clinical scales may still be needed to improve intra- and inter-observer agreement in research studies. Copyright © 2010 Elsevier B.V. All rights reserved.

  10. Retrospective Evaluation of Accelerate Pheno™ System (AXDX, Version 1.1) for Identification/Antimicrobial Susceptibility Testing (ID/AST) of Gram-Negative Bacilli (GNB) including Carbapenemase-Producing Organisms (CPO) from Seeded Blood Culture Bottles (SBCB) Tested using AXDX PhenoTestTM BC Kits

    PubMed Central

    Willey, Barbara M; Gascon, Bryan; Lee, Samantha; Koren, Vita; Surangiwala, Salman; Paterson, Aimee; Lo, Pauline; Boyd, David A; Mulvey, Michael; Mazzulli, Tony; Poutanen, Susan M

    2017-01-01

    Abstract Background AXDX reports ID/AST in <7h from positive blood cultures. Prospective pre-FDA clinical trials were conducted in areas where CPO bacteremia was rare. This study challenged AXDX to detect CPO from SBCB. Methods 53 GNB including 31 CPO (10 KPC, 8 OXA48-type, 4 NDM, 3 GES5, 3 VIM, 1 VIM/GES5, 1 IMP7, 1 SME) were tested in AXDX post SBCB incubation in BacT/Alert® (bioMérieux). Seeding suspensions were parallel-tested by CLSI M100-S27 broth microdilution (BMD) for cefazolin (CFZ), ceftriaxone (CRO), ceftazidime (CAZ), piperacillin/tazobactam (TZP), ertapenem (ETP), meropenem (MEM), ciprofloxacin (CIP), gentamicin (GM), tobramycin (TOB), and amikacin (AN). With GNB-genera combined, AXDX-AST were assessed vs BMD using Cumitech 31A for ≥90% agreements [essential (EA); categorical (CA)] and errors [very major (VME) <3%; combined major/minor (ME/mE) <7%]. Results AXDX produced evaluable results (ID-correct/AST-reported) for 83% GNB (19 Klebsiella species; 13 Escherichia coli; 5 Pseudomonas aeruginosa; 4 Enterobacter cloacae, 2 Proteus mirabilis; 1 Serratia marcescens) tabulated below. Limits were exceeded for underlined values, but 95% confidence intervals (CI) overlapped acceptable limits except in values marked with astericks [95% CI: EA (CRO:58.8–85.6; ETP:31.6–61.4; MEM:62.8–87.3; GEN:48.8–76.3); VME (MEM:11.7–45.2); ME/mE (CAZ:7.8–30.3)]. Of 31 CPO, by BMD/AXDX respectively, 2 (6.5%; P. mirabilis NDM, E. coli KPC)/4 (12.9%; same 2 plus E. cloacae KPC, S. marcescens SME) were ETP+MEM=S, 23 (74.2%)/17 (54.8%) were ETP+MEM=I/R and 6 (19.4%; 5 OXA48; 1 KPC)/12 (38.7%; same plus 14 KPC, 1 NDM, 1 SME) were ETP = I/R but MEM=S. If ETP-I/R alone predicted CPO, BMD/AXDX detected 93.5% (95% CI: 78.3–99.2)/87.1% (95% CI: 70.5–95.5) CPO, respectively (P = 0.6713, NS). But as 3/5 (60%) ETP=R non-CPO were also MEM=S by BMD+AXDX, this rule would incur MEM ME. Conclusion Expert rules based on ETP enabled detection of 87.1% (70.5–95.5%) CPO

  11. 7 CFR 1499.5 - Agreements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Agreements. 1499.5 Section 1499.5 Agriculture... AGRICULTURE EXPORT PROGRAMS FOOD FOR PROGRESS PROGRAM § 1499.5 Agreements. (a) After FAS approves an applicant's proposal, FAS will develop an agreement in consultation with the applicant. The agreement will set...

  12. 7 CFR 1499.5 - Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Agreements. 1499.5 Section 1499.5 Agriculture... AGRICULTURE EXPORT PROGRAMS FOOD FOR PROGRESS PROGRAM § 1499.5 Agreements. (a) After FAS approves an applicant's proposal, FAS will develop an agreement in consultation with the applicant. The agreement will set...

  13. 7 CFR 1499.5 - Agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Agreements. 1499.5 Section 1499.5 Agriculture... AGRICULTURE EXPORT PROGRAMS FOOD FOR PROGRESS PROGRAM § 1499.5 Agreements. (a) After FAS approves an applicant's proposal, FAS will develop an agreement in consultation with the applicant. The agreement will set...

  14. 2 CFR 3001.661 - Reimbursable Agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Reimbursable Agreement. 3001.661 Section 3001.661 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF... Reimbursable Agreement. Reimbursable Agreement means an award in which the recipient is reimbursed for...

  15. 34 CFR 675.35 - Agreement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false Agreement. 675.35 Section 675.35 Education Regulations..., DEPARTMENT OF EDUCATION FEDERAL WORK-STUDY PROGRAMS Job Location and Development Program § 675.35 Agreement... agreement with the Secretary. (b) The agreement must provide— (1) That the institution will administer the...

  16. 34 CFR 675.35 - Agreement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false Agreement. 675.35 Section 675.35 Education Regulations..., DEPARTMENT OF EDUCATION FEDERAL WORK-STUDY PROGRAMS Job Location and Development Program § 675.35 Agreement... agreement with the Secretary. (b) The agreement must provide— (1) That the institution will administer the...

  17. 16 CFR 2.32 - Agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Agreement. 2.32 Section 2.32 Commercial... Consent Order Procedure § 2.32 Agreement. Every agreement in settlement of a Commission complaint shall... of findings of fact and conclusions of law. Every agreement also shall waive further procedural steps...

  18. 34 CFR 675.35 - Agreement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false Agreement. 675.35 Section 675.35 Education Regulations..., DEPARTMENT OF EDUCATION FEDERAL WORK-STUDY PROGRAMS Job Location and Development Program § 675.35 Agreement... agreement with the Secretary. (b) The agreement must provide— (1) That the institution will administer the...

  19. 34 CFR 675.35 - Agreement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false Agreement. 675.35 Section 675.35 Education Regulations..., DEPARTMENT OF EDUCATION FEDERAL WORK-STUDY PROGRAMS Job Location and Development Program § 675.35 Agreement... agreement with the Secretary. (b) The agreement must provide— (1) That the institution will administer the...

  20. 16 CFR 2.32 - Agreement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Agreement. 2.32 Section 2.32 Commercial... Consent Order Procedure § 2.32 Agreement. Every agreement in settlement of a Commission complaint shall... of findings of fact and conclusions of law. Every agreement also shall waive further procedural steps...

  1. 16 CFR 2.32 - Agreement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Agreement. 2.32 Section 2.32 Commercial... Consent Order Procedure § 2.32 Agreement. Every agreement in settlement of a Commission complaint shall... of findings of fact and conclusions of law. Every agreement also shall waive further procedural steps...

  2. 16 CFR 2.32 - Agreement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Agreement. 2.32 Section 2.32 Commercial... Consent Order Procedure § 2.32 Agreement. Every agreement in settlement of a Commission complaint shall... of findings of fact and conclusions of law. Every agreement also shall waive further procedural steps...

  3. 16 CFR 2.32 - Agreement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Agreement. 2.32 Section 2.32 Commercial... Consent Order Procedure § 2.32 Agreement. Every agreement in settlement of a Commission complaint shall... of findings of fact and conclusions of law. Every agreement also shall waive further procedural steps...

  4. 34 CFR 675.35 - Agreement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Agreement. 675.35 Section 675.35 Education Regulations..., DEPARTMENT OF EDUCATION FEDERAL WORK-STUDY PROGRAMS Job Location and Development Program § 675.35 Agreement... agreement with the Secretary. (b) The agreement must provide— (1) That the institution will administer the...

  5. Characterization and mapping of cDNA encoding aspartate aminotransferase in rice, Oryza sativa L.

    PubMed

    Song, J; Yamamoto, K; Shomura, A; Yano, M; Minobe, Y; Sasaki, T

    1996-10-31

    Fifteen cDNA clones, putatively identified as encoding aspartate aminotransferase (AST, EC 2.6.1.1.), were isolated and partially sequenced. Together with six previously isolated clones putatively identified to encode ASTs (Sasaki, et al. 1994, Plant Journal 6, 615-624), their sequences were characterized and classified into 4 cDNA species. Two of the isolated clones, C60213 and C2079, were full-length cDNAs, and their complete nucleotide sequences were determined. C60213 was 1612 bp long and its deduced amino acid sequence showed 88% homology with that of Panicum miliaceum L. mitochondrial AST. The C60213-encoded protein had an N-terminal amino acid sequence that was characteristic of a mitochondrial transit peptide. On the other hand, C2079 was 1546 bp long and had 91% amino acid sequence homology with P. miliaceum L. cytosolic AST but lacked in the transit peptide sequence. The homologies of nucleotide sequences and deduced amino acid sequences of C2079 and C60213 were 54% and 52%, respectively. C2079 and C60213 were mapped on chromosomes 1 and 6, respectively, by restriction fragment length polymorphism linkage analysis. Northern blot analysis using C2079 as a probe revealed much higher transcript levels in callus and root than in green and etiolated shoots, suggesting tissue-specific variations of AST gene expression.

  6. HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib.

    PubMed

    Yang, Guang; Buhrlage, Sara J; Tan, Li; Liu, Xia; Chen, Jie; Xu, Lian; Tsakmaklis, Nicholas; Chen, Jiaji G; Patterson, Christopher J; Brown, Jennifer R; Castillo, Jorge J; Zhang, Wei; Zhang, Xiaofeng; Liu, Shuai; Cohen, Philip; Hunter, Zachary R; Gray, Nathanael; Treon, Steven P

    2016-06-23

    Activating mutations in MYD88 are present in ∼95% of patients with Waldenström macroglobulinemia (WM), as well as other B-cell malignancies including activated B-cell (ABC) diffuse large B-cell lymphoma (DLBCL). In WM, mutated MYD88 triggers activation of Bruton tyrosine kinase (BTK). Ibrutinib, a pleiotropic kinase inhibitor that targets BTK, is highly active in patients with mutated MYD88. We observed that mutated MYD88 WM and ABC DLBCL cell lines, as well as primary WM cells show enhanced hematopoietic cell kinase (HCK) transcription and activation, and that HCK is activated by interleukin 6 (IL-6). Over-expression of mutated MYD88 triggers HCK and IL-6 transcription, whereas knockdown of HCK reduced survival and attenuated BTK, phosphoinositide 3-kinase/AKT, and mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in mutated MYD88 WM and/or ABC DLBCL cells. Ibrutinib and the more potent HCK inhibitor A419259, blocked HCK activation and induced apoptosis in mutated MYD88 WM and ABC DLBCL cells. Docking and pull-down studies confirmed that HCK was a target of ibrutinib. Ibrutinib and A419259 also blocked adenosine triphosphate binding to HCK, whereas transduction of mutated MYD88 expressing WM cells with a mutated HCK gatekeeper greatly increased the half maximal effective concentration for ibrutinib and A419259. The findings support that HCK expression and activation is triggered by mutated MYD88, supports the growth and survival of mutated MYD88 WM and ABC DLBCL cells, and is a direct target of ibrutinib. HCK represents a novel target for therapeutic development in MYD88-mutated WM and ABC DLBCL, and possibly other diseases driven by mutated MYD88. © 2016 by The American Society of Hematology.

  7. 2 CFR 1401.220 - Cooperative agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Cooperative agreement. 1401.220 Section 1401.220 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF THE... agreement. Cooperative agreement means an award of financial assistance that, consistent with 31 U.S.C. 6305...

  8. 49 CFR 605.14 - Agreement.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Agreement. 605.14 Section 605.14 Transportation... TRANSPORTATION SCHOOL BUS OPERATIONS School Bus Agreements § 605.14 Agreement. Except as provided in § 605.11 no... entered into a written agreement that the applicant will not engage in school bus operations exclusively...

  9. 49 CFR 605.14 - Agreement.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Agreement. 605.14 Section 605.14 Transportation... TRANSPORTATION SCHOOL BUS OPERATIONS School Bus Agreements § 605.14 Agreement. Except as provided in § 605.11 no... entered into a written agreement that the applicant will not engage in school bus operations exclusively...

  10. 23 CFR 660.111 - Agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Agreements. 660.111 Section 660.111 Highways FEDERAL... (DIRECT FEDERAL) Forest Highways § 660.111 Agreements. (a) A statewide FH agreement shall be executed among the FHWA, the FS, and each SHA. This agreement shall set forth the responsibilities of each party...

  11. 23 CFR 660.111 - Agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Agreements. 660.111 Section 660.111 Highways FEDERAL... (DIRECT FEDERAL) Forest Highways § 660.111 Agreements. (a) A statewide FH agreement shall be executed among the FHWA, the FS, and each SHA. This agreement shall set forth the responsibilities of each party...

  12. 23 CFR 660.111 - Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Agreements. 660.111 Section 660.111 Highways FEDERAL... (DIRECT FEDERAL) Forest Highways § 660.111 Agreements. (a) A statewide FH agreement shall be executed among the FHWA, the FS, and each SHA. This agreement shall set forth the responsibilities of each party...

  13. 49 CFR 605.14 - Agreement.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Agreement. 605.14 Section 605.14 Transportation... TRANSPORTATION SCHOOL BUS OPERATIONS School Bus Agreements § 605.14 Agreement. Except as provided in § 605.11 no... entered into a written agreement that the applicant will not engage in school bus operations exclusively...

  14. 49 CFR 605.14 - Agreement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Agreement. 605.14 Section 605.14 Transportation... TRANSPORTATION SCHOOL BUS OPERATIONS School Bus Agreements § 605.14 Agreement. Except as provided in § 605.11 no... entered into a written agreement that the applicant will not engage in school bus operations exclusively...

  15. 23 CFR 660.111 - Agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Agreements. 660.111 Section 660.111 Highways FEDERAL... (DIRECT FEDERAL) Forest Highways § 660.111 Agreements. (a) A statewide FH agreement shall be executed among the FHWA, the FS, and each SHA. This agreement shall set forth the responsibilities of each party...

  16. 49 CFR 605.14 - Agreement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Agreement. 605.14 Section 605.14 Transportation... TRANSPORTATION SCHOOL BUS OPERATIONS School Bus Agreements § 605.14 Agreement. Except as provided in § 605.11 no... entered into a written agreement that the applicant will not engage in school bus operations exclusively...

  17. 23 CFR 660.111 - Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Agreements. 660.111 Section 660.111 Highways FEDERAL... (DIRECT FEDERAL) Forest Highways § 660.111 Agreements. (a) A statewide FH agreement shall be executed among the FHWA, the FS, and each SHA. This agreement shall set forth the responsibilities of each party...

  18. Assessment of Interradiologist Agreement Regarding Mammographic Breast Density Classification Using the Fifth Edition of the BI-RADS Atlas.

    PubMed

    Ekpo, Ernest U; Ujong, Ujong Peter; Mello-Thoms, Claudia; McEntee, Mark F

    2016-05-01

    The objective of the present study was to assess interradiologist agreement regarding mammographic breast density assessment performed using the rating scale outlined in the fifth edition of the BI-RADS atlas of the American College of Radiology. Breast density assessments of 1000 cases were conducted by five radiologists from the same institution who together had recently undergone retraining in mammographic breast density classification based on the fifth edition of BI-RADS. The readers assigned breast density grades (A-D) on the basis of the BI-RADS classification scheme. Repeat assessment of 100 cases was performed by all readers 1 month after the initial assessment. A weighted kappa was used to calculate intrareader and interreader agreement. Intrareader agreement ranged from a kappa value of 0.86 (95% CI, 0.77-0.93) to 0.89 (95% CI, 0.81-0.95) on a four-category scale (categories A-D) and from 0.89 (95% CI, 0.86-0.92) to 0.94 (95% CI, 0.89-0.97) on a two-category scale (category A-B vs category C-D). Interreader agreement ranged from substantial (κ = 0.76; 95% CI, 0.73-0.78) to almost perfect (κ = 0.87; 95% CI, 0.86-0.89) on a four-category scale, and the overall weighted kappa value was substantial (0.79; 95% CI, 0.78-0.83). Interreader agreement on a two-category scale ranged from a kappa value of 0.85 (95% CI, 0.83-0.86) to 0.91 (95% CI, 0.90-0.92), and the overall weighted kappa was 0.88 (95% CI, 0.87-0.89). Overall, with regard to mammographic breast density classification, radiologists had substantial interreader agreement when a four-category scale was used and almost perfect interreader agreement when a dichotomous scale was used.

  19. Agreement of angle closure assessments between gonioscopy, anterior segment optical coherence tomography and spectral domain optical coherence tomography.

    PubMed

    Tay, Elton Lik Tong; Yong, Vernon Khet Yau; Lim, Boon Ang; Sia, Stelson; Wong, Elizabeth Poh Ying; Yip, Leonard Wei Leon

    2015-01-01

    To determine angle closure agreements between gonioscopy and anterior segment optical coherence tomography (AS-OCT), as well as gonioscopy and spectral domain OCT (SD-OCT). A secondary objective was to quantify inter-observer agreements of AS-OCT and SD-OCT assessments. Seventeen consecutive subjects (33 eyes) were recruited from the study hospital's Glaucoma clinic. Gonioscopy was performed by a glaucomatologist masked to OCT results. OCT images were read independently by 2 other glaucomatologists masked to gonioscopy findings as well as each other's analyses of OCT images. Totally 84.8% and 45.5% of scleral spurs were visualized in AS-OCT and SD-OCT images respectively (P<0.01). The agreement for angle closure between AS-OCT and gonioscopy was fair at k=0.31 (95% confidence interval, CI: 0.03-0.59) and k=0.35 (95% CI: 0.07-0.63) for reader 1 and 2 respectively. The agreement for angle closure between SD-OCT and gonioscopy was fair at k=0.21 (95% CI: 0.07-0.49) and slight at k=0.17 (95% CI: 0.08-0.42) for reader 1 and 2 respectively. The inter-reader agreement for angle closure in AS-OCT images was moderate at 0.51 (95% CI: 0.13-0.88). The inter-reader agreement for angle closure in SD-OCT images was slight at 0.18 (95% CI: 0.08-0.45). Significant proportion of scleral spurs were not visualised with SD-OCT imaging resulting in weaker inter-reader agreements. Identifying other angle landmarks in SD-OCT images will allow more consistent angle closure assessments. Gonioscopy and OCT imaging do not always agree in angle closure assessments but have their own advantages, and should be used together and not exclusively.

  20. Agreement of angle closure assessments between gonioscopy, anterior segment optical coherence tomography and spectral domain optical coherence tomography

    PubMed Central

    Tay, Elton Lik Tong; Yong, Vernon Khet Yau; Lim, Boon Ang; Sia, Stelson; Wong, Elizabeth Poh Ying; Yip, Leonard Wei Leon

    2015-01-01

    AIM To determine angle closure agreements between gonioscopy and anterior segment optical coherence tomography (AS-OCT), as well as gonioscopy and spectral domain OCT (SD-OCT). A secondary objective was to quantify inter-observer agreements of AS-OCT and SD-OCT assessments. METHODS Seventeen consecutive subjects (33 eyes) were recruited from the study hospital's Glaucoma clinic. Gonioscopy was performed by a glaucomatologist masked to OCT results. OCT images were read independently by 2 other glaucomatologists masked to gonioscopy findings as well as each other's analyses of OCT images. RESULTS Totally 84.8% and 45.5% of scleral spurs were visualized in AS-OCT and SD-OCT images respectively (P<0.01). The agreement for angle closure between AS-OCT and gonioscopy was fair at k=0.31 (95% confidence interval, CI: 0.03-0.59) and k=0.35 (95% CI: 0.07-0.63) for reader 1 and 2 respectively. The agreement for angle closure between SD-OCT and gonioscopy was fair at k=0.21 (95% CI: 0.07-0.49) and slight at k=0.17 (95% CI: 0.08-0.42) for reader 1 and 2 respectively. The inter-reader agreement for angle closure in AS-OCT images was moderate at 0.51 (95% CI: 0.13-0.88). The inter-reader agreement for angle closure in SD-OCT images was slight at 0.18 (95% CI: 0.08-0.45). CONCLUSION Significant proportion of scleral spurs were not visualised with SD-OCT imaging resulting in weaker inter-reader agreements. Identifying other angle landmarks in SD-OCT images will allow more consistent angle closure assessments. Gonioscopy and OCT imaging do not always agree in angle closure assessments but have their own advantages, and should be used together and not exclusively. PMID:25938053