In vitro cytotoxicity of white MTA, MTA Fillapex® and Portland cement on human periodontal ligament fibroblasts.

PubMed

Yoshino, Patrícia; Nishiyama, Celso Kenji; Modena, Karin Cristina da Silva; Santos, Carlos Ferreira; Sipert, Carla Renata

2013-01-01

The aim of this study was to compare the in vitro cytotoxicity of white mineral trioxide aggregate (MTA), MTA Fillapex® and Portland cement (PC) on human cultured periodontal ligament fibroblasts. Periodontal ligament fibroblast culture was established and the cells were used for cytotoxic tests after the fourth passage. Cell density was set at 1.25 X10 4 cells/well in 96-well plates. Endodontic material extracts were prepared by placing sealer/cement specimens (5x3mm) in 1mL of culture medium for 72 h. The extracts were then serially two-fold diluted and inserted into the cell-seeded wells for 24, 48 and 72 h. MTT assay was employed for analysis of cell viability. Cell supernatants were tested for nitric oxide using the Griess reagent system. MTA presented cytotoxic effect in undiluted extracts at 24 and 72 h. MTA Fillapex® presented the highest cytotoxic levels with important cell viability reduction for pure extracts and at ½ and ¼ dilutions. In this study, PC did not induce alterations in fibroblast viability. Nitric oxide was detected in extract-treated cell supernatants and also in the extracts only, suggesting presence of nitrite in the soluble content of the tested materials. In the present study, MTA Fillapex displayed the highest cytotoxic effect on periodontal ligament fibroblasts followed by white MTA and PC.

MTA3 regulates CGB5 and Snail genes in trophoblast

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Ying; Miyazaki, Jun; Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake

Highlights: •Impaired MTA3, raised CGB5 and Snail expression are associated with preeclampsia. •Knock-down of MTA3 causes up-regulation of CGB5 and Snail genes in BeWo cells. •MTA3 occupies CGB5 and Snail gene promoters in BeWo cells. -- Abstract: Secreted by the placental trophoblast, human chorionic gonadotropin (hCG) is an important hormone during pregnancy and is required for the maintenance of pregnancy. Previous studies have shown that dys-regulation of hCG expression is associated with preeclampsia. However, the exact relationship between altered hCG levels and development of preeclampsia is unknown. Metastasis associated protein 3 (MTA3), a chromatin remodeling protein, is abundantly expressed inmore » the placental trophoblasts, but its function is unknown. In breast cancer, MTA3 has been shown to repress the expression of Snail and cell migration. However, whether MTA3 acts similarly in the trophoblast has not been investigated. In the present study, we examined the role of MTA3 in regulating the hCG β-subunit gene (gene name: CGB5) and Snail expression in the trophoblast cell line, BeWo, as well as its relevance to the high hCG expression levels seen in preeclampsia. First, we investigated MTA3 expression in preeclamptic placenta as compared to normal control placenta via gene expression microarray and qRT-PCR and found that MTA3 was significantly down-regulated, whereas both CGB5 and Snail were up-regulated in preeclamptic placenta. Secondly, we knocked down MTA3 gene in trophoblast cell line BeWo and found Snail and hCG were both up-regulated, suggesting that MTA3 represses Snail and hCG gene expression in trophoblasts. Next, we cloned the CGB5 and Snail promoters into the pGL3-basic vector individually and found that silencing of MTA3 by siRNA resulted in an increase of both CGB5 and Snail promoter activities. To confirm that this MTA3 inhibition is a direct effect, we performed a chromatin immune-precipitation (ChIP) assay and found that MTA

MTA family of coregulators in nuclear receptor biology and pathology

PubMed Central

Manavathi, Bramanandam; Singh, Kamini; Kumar, Rakesh

2007-01-01

Nuclear receptors (NRs) rely on coregulators (coactivators and corepressors) to modulate the transcription of target genes. By interacting with nucleosome remodeling complexes, NR coactivators potentiate transcription, whereas corepressors inhibit transcription of the target genes. Metastasis-associated proteins (MTA) represent an emerging family of novel NR coregulators. In general, MTA family members form independent nucleosome remodeling and deacetylation (NuRD) complexes and repress the transcription of different genes by recruiting histone deacetylases onto their target genes. However, MTA1 also acts as a coactivator in a promoter-context dependent manner. Recent findings that repression of estrogen receptor transactivation functions by MTA1, MTA1s, and MTA2 and regulation of MTA3 by estrogen signaling have indicated the significance of these proteins in NR signaling. Here, we highlight the action of MTA proteins on NR signaling and their roles in pathophysiological conditions. PMID:18174918

7 CFR 1221.234 - Confidentiality

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 10 2014-01-01 2014-01-01 false Confidentiality 1221.234 Section 1221.234 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... persons voting in the referendum and ballots shall be confidential and the contents of the ballots shall...

7 CFR 1221.234 - Confidentiality

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 10 2012-01-01 2012-01-01 false Confidentiality 1221.234 Section 1221.234 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... persons voting in the referendum and ballots shall be confidential and the contents of the ballots shall...

7 CFR 1221.234 - Confidentiality

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 10 2013-01-01 2013-01-01 false Confidentiality 1221.234 Section 1221.234 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... persons voting in the referendum and ballots shall be confidential and the contents of the ballots shall...

7 CFR 1221.234 - Confidentiality

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 10 2011-01-01 2011-01-01 false Confidentiality 1221.234 Section 1221.234 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... persons voting in the referendum and ballots shall be confidential and the contents of the ballots shall...

MTA1 regulation of ERβ pathway in salivary gland carcinoma cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ohshiro, Kazufumi, E-mail: bcmkxo@gwu.edu; Kumar, Rakesh

Abstracts: Although Metastatic-tumor antigen 1 (MTA1) is differentially expressed in metastatic cancer and coregulates the status and activity of nuclear receptors, its role upon estrogen receptor β (ERβ) – a potent tumor suppressor, remains poorly understood. Here we investigated whether MTA1 regulates the expression and functions of ERβ, an ER isoform predominantly expressed in salivary gland cancer cells. We found that the depletion of the endogenous MTA1 in the HSG and HSY salivary duct carcinoma cell lines enhances the expression of ERβ while MTA1 overexpression augmented the expression of ERβ in salivary duct carcinoma cells. Furthermore, MTA1 knockdown inhibited themore » proliferations and invasion of HSG and HSY cells. The noted ERβ downregulation by MTA1 overexpression involves the process of proteasomal degradation, as a proteasome inhibitor could block it. In addition, both MTA1 knockdown and ERβ overexpression attenuated the cell migration and inhibited the ERK1/2 signaling in the both cell lines. These findings imply that MTA1 dysregulation in a subset of salivary gland cancer might promote aggressive phenotypes by compromising the tumor suppressor activity of ERβ, and hence, MTA1-ERβ axis might serve a new therapeutic target for the salivary gland cancer. - Highlights: • MTA1 silencing upregulates ERβ expression in salivary gland carcinoma cells. • MTA1 overexpression downregulates ERβ expression via proteasomal degradation. • Upregulation of ERβ expression inhibits cell migration and ERK signaling. • MTA1 knockdown inhibits cell proliferation and invasion.« less

Improved assessment of multiple sclerosis lesion segmentation agreement via detection and outline error estimates

PubMed Central

2012-01-01

Background Presented is the method “Detection and Outline Error Estimates” (DOEE) for assessing rater agreement in the delineation of multiple sclerosis (MS) lesions. The DOEE method divides operator or rater assessment into two parts: 1) Detection Error (DE) -- rater agreement in detecting the same regions to mark, and 2) Outline Error (OE) -- agreement of the raters in outlining of the same lesion. Methods DE, OE and Similarity Index (SI) values were calculated for two raters tested on a set of 17 fluid-attenuated inversion-recovery (FLAIR) images of patients with MS. DE, OE, and SI values were tested for dependence with mean total area (MTA) of the raters' Region of Interests (ROIs). Results When correlated with MTA, neither DE (ρ = .056, p=.83) nor the ratio of OE to MTA (ρ = .23, p=.37), referred to as Outline Error Rate (OER), exhibited significant correlation. In contrast, SI is found to be strongly correlated with MTA (ρ = .75, p < .001). Furthermore, DE and OER values can be used to model the variation in SI with MTA. Conclusions The DE and OER indices are proposed as a better method than SI for comparing rater agreement of ROIs, which also provide specific information for raters to improve their agreement. PMID:22812697

Cytotoxicity, Biocompatibility, and Biomineralization of the New High-plasticity MTA Material.

PubMed

Cintra, Luciano Tavares Angelo; Benetti, Francine; de Azevedo Queiroz, Índia Olinta; de Araújo Lopes, Juliana Maria; Penha de Oliveira, Sandra Helena; Sivieri Araújo, Gustavo; Gomes-Filho, João Eduardo

2017-05-01

Mineral trioxide aggregate (MTA) has excellent biological properties, but its handling properties have been criticized for both ProRoot MTA (Tulsa Dental Products, Tulsa, OK) and white MTA-Angelus (MTA-Ang; Angelus Indústria de Produtos Odontológicos S/A, Londrina, PR, Brazil). Angelus MTA HP (high plasticity) (Angelus Indústria de Produtos Odontológicos S/A) has been introduced recently. Considering the importance of biological properties of materials that will be in contact with the tissues, this study evaluated the cytotoxicity, biocompatibility, and biomineralization of MTA HP compared with white MTA-Ang. L929 fibroblast cell lines were cultured, and cell viability was assessed at 6, 24, 48, and 72 hours using the alamar Blue assay (Thermo Fisher Scientific, Waltham, MA). A subcutaneous implant test was performed with polyethylene tubes containing 1 of the materials or empty tubes (control) using 20 Wistar rats. After 7 and 30 days of implantation, the tubes with surrounding tissues were removed for analysis using hematoxylin-eosin or von Kossa stain or they remained unstained for observation under polarized light. The results were statistically analyzed (P < .05). A significant increase in cell viability for MTA HP was observed after 24, 48, and 72 hours compared with the control (P < .05). At 72 hours, MTA HP exhibited a higher viability compared with white MTA-Ang (P < .05). Histologic analysis performed at 7 days showed moderate inflammation and a thick fibrous capsule in all groups (P > .05). At 30 days, mild inflammation and a thin fibrous capsule were observed in all groups (P > .05). All materials had structures positive for von Kossa and birefringent to polarized light. MTA HP showed biocompatibility and biomineralization similar to MTA-Ang. In addition, MTA HP showed increased fibroblast cell viability compared with white MTA-Ang after a longer period. Copyright © 2017 American Association of Endodontists. Published by Elsevier

Physiochemical properties of experimental nano-hybrid MTA

PubMed Central

Akhavan Zanjani, V; Tabari, K; Sheikh-Al-Eslamian, SM; Abrandabadi, AN

2017-01-01

Introduction: Development of new pulp capping agents has paved the way towards the preservation of pulp vitality, which is an important goal in restorative dentistry. This study sought to assess the calcium ion release, pH and setting of mineral trioxide aggregate (MTA) Angelus, an experimental formulation of nano-hybrid MTA containing nano-SiO2, nano-Al2O3 and nano-TiO2 and MTA Angelus plus nano-oxides. Methods: In this experimental study, five specimens from each material were placed in polypropylene tubes and immersed in a flask containing deionized distilled water. The quantity of calcium ions released into the solution from each material was measured at 15 minutes, one hour, and 24 hours by using atomic absorption spectroscopy. The pH of the solutions was measured by using a pH meter at the respective time points. The setting time was also assessed by using a Gilmore needle. Data were analyzed by using repeated measure ANOVA. Results: The quantity of released calcium ions was not significantly different among the groups (P=0.060). All materials were alkaline and the pH at 24 hours was significantly higher than the other two time points in all groups (P<0.001). The experimental group had the shortest and the MTA Angelus had the longest setting time. All materials were alkaline and capable of releasing calcium. Addition of nanoparticles to MTA Angelus significantly decreased the setting time but had no effect on the release of calcium ions or pH. Abbreviations: MTA = mineral trioxide aggregate, VPT = vital pulp therapy PMID:29075348

Material Transfer Agreement (MTA) | FNLCR Staging

Cancer.gov

Material Transfer Agreements are appropriate for exchange of materials into or out of the Frederick National Labfor research or testing purposes, with no collaborative research by parties involving the materials.

7 CFR 900.309 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 900.309 Section 900.309... to Agricultural Marketing Agreement Act of 1937, as Amended § 900.309 Confidential information. The... information furnished to, compiled by, or in the possession of the referendum agent, shall be regarded as...

19 CFR 181.121 - Maintenance of confidentiality.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 181.121 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Confidentiality of Business... possession of confidential business information collected pursuant to this part shall, in accordance with...

7 CFR 900.407 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 900.407 Section 900.407... to the Agricultural Marketing Agreement Act of 1937, as Amended § 900.407 Confidential information... voted or the manner in which any person voted) and all information furnished to, compiled by, or in...

Cryogenics for the MuCool Test Area (MTA)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Darve, Christine; Norris, Barry; Pei, Liu-Jin

2005-09-01

MuCool Test Area (MTA) is a complex of buildings at Fermi National Accelerator Laboratory, which are dedicated to operate components of a cooling cell to be used for Muon Collider and Neutrino Factory R&D. The long-term goal of this facility is to test ionization cooling principles by operating a 25-liter liquid hydrogen (LH{sub 2}) absorber embedded in a 5 Tesla superconducting solenoid magnet. The MTA solenoid magnet will be used with RF cavities exposed to a high intensity beam. Cryogens used at the MTA include LHe, LN{sub 2} and LH{sub 2}. The latter dictates stringent system design for hazardous locations.more » The cryogenic plant is a modified Tevatron refrigerator based on the Claude cycle. The implementation of an in-house refrigerator system and two 300 kilowatt screw compressors is under development. The helium refrigeration capacity is 500 W at 14 K. In addition the MTA solenoid magnet will be batch-filled with LHe every 2 days using the same cryo-plant. This paper reviews cryogenic systems used to support the Muon Collider and Neutrino Factory R&D programs and emphasizes the feasibility of handling cryogenic equipment at MTA in a safe manner.« less

Cryogenics for the MuCool Test Area (MTA)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Darve, Christine; Norris, Barry; Pei, Liujin

2006-03-20

MuCool Test Area (MTA) is a complex of buildings at Fermi National Accelerator Laboratory, which are dedicated to operate components of a cooling cell to be used for Muon Collider and Neutrino Factory R and D. The long-term goal of this facility is to test ionization cooling principles by operating a 25-liter liquid hydrogen (LH2) absorber embedded in a 5 Tesla superconducting solenoid magnet. The MTA solenoid magnet will be used with RF cavities exposed to a high intensity beam. Cryogens used at the MTA include LHe, LN2 and LH2. The latter dictates stringent system design for hazardous locations. Themore » cryogenic plant is a modified Tevatron refrigerator based on the Claude cycle. The implementation of an in-house refrigerator system and two 300 kilowatt screw compressors is under development. The helium refrigeration capacity is 500 W at 14 K. In addition the MTA solenoid magnet will be batch-filled with LHe every 2 days using the same cryo-plant. This paper reviews cryogenic systems used to support the Muon Collider and Neutrino Factory R and D programs and emphasizes the feasibility of handling cryogenic equipment at MTA in a safe manner.« less

The MTA family proteins as novel histone H3 binding proteins.

PubMed

Wu, Meng; Wang, Lina; Li, Qian; Li, Jiwen; Qin, Jun; Wong, Jiemin

2013-01-03

The nucleosome remodeling and histone deacetylase complex (Mi2/NRD/NuRD/NURD) has a broad role in regulation of transcription, DNA repair and cell cycle. Previous studies have revealed a specific interaction between NURD and histone H3N-terminal tail in vitro that is not observed for another HDAC1/2-containing complex, Sin3A. However, the subunit(s) responsible for specific binding of H3 by NURD has not been defined. In this study, we show among several class I HDAC-containing corepressor complexes only NURD exhibits a substantial H3 tail-binding activity in vitro. We present the evidence that the MTA family proteins within the NURD complex interact directly with H3 tail. Extensive in vitro binding assays mapped the H3 tail-binding domain to the C-terminal region of MTA1 and MTA2. Significantly, although the MTA1 and MTA2 mutant proteins with deletion of the C-terminal H3 tail binding domain were assembled into the endogenous NURD complex when expressed in mammalian cells, the resulting NURD complexes were deficient in binding H3 tail in vitro, indicating that the MTA family proteins are required for the observed specific binding of H3 tail peptide by NURD in vitro. However, chromatin fractionation experiments show that the NURD complexes with impaired MTA1/2-H3 tail binding activity remained to be associated with chromatin in cells. Together our study reveals a novel histone H3-binding activity for the MTA family proteins and provides evidence that the MTA family proteins mediate the in vitro specific binding of H3 tail peptide by NURD complex. However, multiple mechanisms are likely to contribute to the chromatin association of NURD complex in cells. Our finding also raises the possibility that the MTA family proteins may exert their diverse biological functions at least in part through their direct interaction with H3 tail.

The MTA family proteins as novel histone H3 binding proteins

PubMed Central

2013-01-01

Background The nucleosome remodeling and histone deacetylase complex (Mi2/NRD/NuRD/NURD) has a broad role in regulation of transcription, DNA repair and cell cycle. Previous studies have revealed a specific interaction between NURD and histone H3N-terminal tail in vitro that is not observed for another HDAC1/2-containing complex, Sin3A. However, the subunit(s) responsible for specific binding of H3 by NURD has not been defined. Results In this study, we show among several class I HDAC-containing corepressor complexes only NURD exhibits a substantial H3 tail-binding activity in vitro. We present the evidence that the MTA family proteins within the NURD complex interact directly with H3 tail. Extensive in vitro binding assays mapped the H3 tail-binding domain to the C-terminal region of MTA1 and MTA2. Significantly, although the MTA1 and MTA2 mutant proteins with deletion of the C-terminal H3 tail binding domain were assembled into the endogenous NURD complex when expressed in mammalian cells, the resulting NURD complexes were deficient in binding H3 tail in vitro, indicating that the MTA family proteins are required for the observed specific binding of H3 tail peptide by NURD in vitro. However, chromatin fractionation experiments show that the NURD complexes with impaired MTA1/2-H3 tail binding activity remained to be associated with chromatin in cells. Conclusions Together our study reveals a novel histone H3-binding activity for the MTA family proteins and provides evidence that the MTA family proteins mediate the in vitro specific binding of H3 tail peptide by NURD complex. However, multiple mechanisms are likely to contribute to the chromatin association of NURD complex in cells. Our finding also raises the possibility that the MTA family proteins may exert their diverse biological functions at least in part through their direct interaction with H3 tail. PMID:23286669

4-MTA: a new synthetic drug on the dance scene.

PubMed

Winstock, Adam R; Wolff, Kim; Ramsey, John

2002-07-01

4-MTA (p-methylthioamphetamine) is a new synthetic sulphur derivative of amphetamine that has been associated with six deaths since it was first identified in Europe in 1997. Sold as 'ecstasy' or 'Flatliners', the drug like MDMA is a potent serotonin releaser. Using a self-nominated sampling methodology we accessed over 1000 dance drug users through a magazine survey. Ten percent of respondents thought that they had used 4-MTA. Those with experience of 4-MTA tended to come from a sub-population of heavy 'ecstasy'-users. Responses to the effects of the drug were mixed, although about a quarter of those who believed that they had tried 4-MTA thought that they would use it again.

Resistance to vertical fracture of MTA-filled roots.

PubMed

EL-Ma'aita, Ahmad M; Qualtrough, Alison J E; Watts, David C

2014-02-01

To investigate the effect of MTA root canal fillings on the resistance to vertical root fracture (VRF) over different time intervals. Freshly extracted anterior human teeth with single canals and minimal curvatures were decoronated, instrumented to size 50/.05 ProTaper file, irrigated with 1%NaOCl and randomly allocated to one of three groups (n = 36): (i) filled with MTA, (ii) filled with gutta-percha and sealer and (iii) unfilled roots used as a negative control. Each group was subdivided into three subgroups (n = 12) according to the storage time of 48 h, 1 and 6 months at 37°C in synthetic tissue fluid (STF). Following the storage periods, filled roots were mounted in acrylic supports, and the periodontal ligament was simulated using elastomeric impression material. Vertical loading was carried out with a ball-ended steel cylinder fitted on a universal testing machine at 1 mm/min crosshead speed. The maximum force at fracture (F-max) and the fracture mode were recorded for each root. Data were statistically analysed using two-way anova and Bonferroni post hoc tests. The mean F-max was significantly higher in the MTA subgroups after 1 and 6 months compared with all other subgroups. Two modes of fracture were identified: split and comminuted. The mean F-max values recorded with the latter were significantly higher compared with the former (P < 0.001). In all groups, split fracture was the most dominant mode apart from the MTA/1 month and MTA/6 month groups. MTA increases the resistance to VRF of endodontically treated teeth and influences the mode of fracture after 1 and 6 month of storage in STF compared with gutta-percha and sealer. © 2013 John Wiley & Sons A/S.

47 CFR 90.665 - Authorization, construction and implementation of MTA licenses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... years from the date of license grant, construct and place into operation a sufficient number of base stations to provide coverage to at least one-third of the population of the MTA; further, each MTA licensee must provide coverage to at least two-thirds of the population of the MTA five years from the date of...

47 CFR 90.665 - Authorization, construction and implementation of MTA licenses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... years from the date of license grant, construct and place into operation a sufficient number of base stations to provide coverage to at least one-third of the population of the MTA; further, each MTA licensee must provide coverage to at least two-thirds of the population of the MTA five years from the date of...

47 CFR 90.665 - Authorization, construction and implementation of MTA licenses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... years from the date of license grant, construct and place into operation a sufficient number of base stations to provide coverage to at least one-third of the population of the MTA; further, each MTA licensee must provide coverage to at least two-thirds of the population of the MTA five years from the date of...

47 CFR 90.665 - Authorization, construction and implementation of MTA licenses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... years from the date of license grant, construct and place into operation a sufficient number of base stations to provide coverage to at least one-third of the population of the MTA; further, each MTA licensee must provide coverage to at least two-thirds of the population of the MTA five years from the date of...

47 CFR 90.665 - Authorization, construction and implementation of MTA licenses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... years from the date of license grant, construct and place into operation a sufficient number of base stations to provide coverage to at least one-third of the population of the MTA; further, each MTA licensee must provide coverage to at least two-thirds of the population of the MTA five years from the date of...

7 CFR 1207.352 - Confidential treatment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan Reports, Books, and Records § 1207.352 Confidential treatment...

7 CFR 1207.352 - Confidential treatment.

Code of Federal Regulations, 2013 CFR

2013-01-01

... AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan Reports, Books, and Records § 1207.352 Confidential treatment...

7 CFR 1207.352 - Confidential treatment.

Code of Federal Regulations, 2014 CFR

2014-01-01

... AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan Reports, Books, and Records § 1207.352 Confidential treatment...

7 CFR 1207.352 - Confidential treatment.

Code of Federal Regulations, 2012 CFR

2012-01-01

... AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan Reports, Books, and Records § 1207.352 Confidential treatment...

7 CFR 1207.352 - Confidential treatment.

Code of Federal Regulations, 2011 CFR

2011-01-01

... AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan Reports, Books, and Records § 1207.352 Confidential treatment...

3-Year Follow-up of the NIMH MTA Study

ERIC Educational Resources Information Center

Jensen, Peter S.; Arnold, L. Eugene; Swanson, James M.; Vitiello, Benedetto; Abikoff, Howard B.; Greenhill, Laurence L.; Hechtman, Lily; Hinshaw, Stephen P.; Pelham, William E.; Wells, Karen C.; Conners, C. Keith; Elliott, Glen R.; Epstein, Jeffery N.; Hoza, Betsy; March, John S.; Molina, Brooke S. G.; Newcorn, Jeffrey H.; Severe, Joanne B.; Wigal, Timothy; Gibbons, Robert D.; Hur, Kwan

2007-01-01

Objective: In the intent-to-treat analysis of the Multimodal Treatment Study of Children With ADHD (MTA), the effects of medication management (MedMgt), behavior therapy (Beh), their combination (Comb), and usual community care (CC) differed at 14 and 24 months due to superiority of treatments that used the MTA medication algorithm (Comb+MedMgt)…

MTA and F-doped MTA cements used as sealers with warm gutta-percha. Long-term study of sealing ability.

PubMed

Gandolfi, M G; Prati, C

2010-10-01

To evaluate the long-term sealing ability (up to 6 months) of two experimental calcium silicate MTA cements used as root canal sealers in association with warm gutta-percha. Calcium silicate (MTA) and calcium-fluoro-silicate powders were prepared. Sodium fluoride was included in FMTA (Fluoride-doped Mineral Trioxide Aggregate) as an expansive and retardant agent. Single-rooted teeth were instrumented with NiTi rotary instruments, filled with warm gutta-percha in association with one of the experimental sealers or with AH Plus as a control (n = 20 for each sealer) and stored at 37 °C. Sealing was assessed at 24, 48 h, 1, 2 weeks and 1, 3, 6 months by a fluid filtration method. Scanning electron microscopy with energy dispersive analysis (SEM/EDX) was used to study the dentine/sealer interface of roots stored for 6 months and the surface of cement disks stored for 24 h. All sealers revealed a statistically significant reduction (P < 0.05) in fluid filtration after the first 2 weeks. No statistically significant differences were observed between FMTA and AH Plus at all analysis times. At short times (24, 48-h), no statistically significant differences were found between the experimental cements and AH Plus. At long-term evaluations (1, 3, 6 months), FMTA and AH Plus sealed significantly better (P < 0.05) than MTA. FMTA was associated with lower fluid filtration rates, and the seal was stable from 48 h to 6 months, thus proving the most effective material. Scanning electron microscopy with energy dispersive analysis of root sections filled with calcium silicate sealers revealed the formation of a blend layer of gutta-percha and cement consequent to the warm gutta-percha condensation technique. Scanning electron microscopy with energy dispersive analysis of 24-h-stored disks identified a Ca-rich coating on the outer surface consisting of globular particles (calcium hydroxide and calcium carbonate), and a deeper internal Ca- and Si-rich region consisting of needle

Antimicrobial activity of ProRoot MTA in contact with blood

PubMed Central

Farrugia, C.; Baca, P.; Camilleri, J.; Arias Moliz, M. T.

2017-01-01

Dental materials based on Portland cement, which is used in the construction industry have gained popularity for clinical use due to their hydraulic properties, the interaction with tooth tissue and their antimicrobial properties. The antimicrobial properties are optimal in vitro. However in clinical use contact with blood may affect the antimicrobial properties. This study aims to assess whether antimicrobial properties of the Portland cement-based dental cements such as mineral trioxide aggregate (MTA) are also affected by contact with blood present in clinical situations. ProRoot MTA, a Portland cement-based dental cement was characterized following contact with water, or heparinized blood after 1 day and 7 days aging. The antimicrobial activity under the mentioned conditions was assessed using 3 antimicrobial tests: agar diffusion test, direct contact test and intratubular infection test. MTA in contact with blood was severely discoloured, exhibited an additional phosphorus peak in elemental analysis, no calcium hydroxide peaks and no areas of bacterial inhibition growth in the agar diffusion test were demonstrated. ProRoot MTA showed limited antimicrobial activity, in both the direct contact test and intratubular infection test. When aged in water ProRoot MTA showed higher antimicrobial activity than when aged in blood. Antimicrobial activity reduced significantly after 7 days. Further assessment is required to investigate behaviour in clinical situations. PMID:28128328

Characterization of un-hydrated and hydrated BioAggregate™ and MTA Angelus™.

PubMed

Camilleri, J; Sorrentino, F; Damidot, D

2015-04-01

BioAggregate™ is a novel material introduced for use as a root-end filling material. It is tricalcium silicate-based, free of aluminium and uses tantalum oxide as radiopacifier. BioAggregate contains additives to enhance the material performance. The purpose of this research was to characterize the un-hydrated and hydrated forms of BioAggregate using a combination of techniques, verify whether the additives if present affect the properties of the set material and compare these properties to those of MTA Angelus™. Un-hydrated and hydrated BioAggregate and MTA Angelus were assessed. Un-hydrated cement was tested for chemical composition, specific surface area, mineralogy and kinetics of hydration. The set material was investigated for mineralogy, microstructure and bioactivity. Scanning electron microscopy, X-ray energy dispersive spectroscopic analysis, X-ray fluorescence spectroscopy, X-ray diffraction and isothermal calorimetry were employed. The specific surface area was investigated using a gas adsorption method with nitrogen as the probe. BioAggregate was composed of tricalcium silicate, tantalum oxide, calcium phosphate and silicon dioxide and was free of aluminium. On hydration, the tricalcium silicate produced calcium silicate hydrate and calcium hydroxide. The former was deposited around the cement grains, while the latter reacted with the silicon dioxide to form additional calcium silicate hydrate. This resulted in reduction of calcium hydroxide in the aged cement. MTA Angelus reacted in a similar fashion; however, since it contained no additives, the calcium hydroxide was still present in the aged cement. Bioactivity was demonstrated by deposition of hydroxyapatite. BioAggregate exhibited a high specific surface area. Nevertheless, the reactivity determined by isothermal calorimetry appeared to be slow compared to MTA Angelus. The tantalum oxide as opposed to bismuth oxide was inert, and tantalum was not leached in solution. BioAggregate exhibited

Medical confidentiality: an intransigent and absolute obligation.

PubMed Central

Kottow, M H

1986-01-01

Clinicians' work depends on sincere and complete disclosures from their patients; they honour this candidness by confidentially safeguarding the information received. Breaching confidentiality causes harms that are not commensurable with the possible benefits gained. Limitations or exceptions put on confidentiality would destroy it, for the confider would become suspicious and un-co-operative, the confidant would become untrustworthy and the whole climate of the clinical encounter would suffer irreversible erosion. Excusing breaches of confidence on grounds of superior moral values introduces arbitrariness and ethical unreliability into the medical context. Physicians who breach the agreement of confidentiality are being unfair, thus opening the way for, and becoming vulnerable to, the morally obtuse conduct of others. Confidentiality should not be seen as the cosy but dispensable atmosphere of clinical settings; rather, it constitutes a guarantee of fairness in medical actions. Possible perils that might accrue to society are no greater than those accepted when granting inviolable custody of information to priests, lawyers and bankers. To jeopardize the integrity of confidential medical relationships is too high a price to pay for the hypothetical benefits this might bring to the prevailing social order. PMID:3761330

7 CFR 1214.107 - Confidential information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 10 2012-01-01 2012-01-01 false Confidential information. 1214.107 Section 1214.107 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE CHRISTMAS TREE PROMOTION...

7 CFR 1214.107 - Confidential information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 10 2013-01-01 2013-01-01 false Confidential information. 1214.107 Section 1214.107 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE CHRISTMAS TREE PROMOTION...

7 CFR 1214.107 - Confidential information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 10 2014-01-01 2014-01-01 false Confidential information. 1214.107 Section 1214.107 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE CHRISTMAS TREE PROMOTION...

7 CFR 1219.108 - Confidential information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 10 2011-01-01 2011-01-01 false Confidential information. 1219.108 Section 1219.108 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE HASS AVOCADO PROMOTION, RESEARCH...

7 CFR 1219.108 - Confidential information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 10 2014-01-01 2014-01-01 false Confidential information. 1219.108 Section 1219.108 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE HASS AVOCADO PROMOTION, RESEARCH...

7 CFR 1212.107 - Confidential information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 10 2011-01-01 2011-01-01 false Confidential information. 1212.107 Section 1212.107 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE HONEY PACKERS AND IMPORTERS...

MTA Computer Based Evaluation System.

ERIC Educational Resources Information Center

Brenner, Lisa P.; And Others

The MTA PLATO-based evaluation system, which has been implemented by a consortium of schools of medical technology, is designed to be general-purpose, modular, data-driven, and interactive, and to accommodate other national and local item banks. The system provides a comprehensive interactive item-banking system in conjunction with online student…

In vitro methanol production from methyl coenzyme M using the Methanosarcina barkeri MtaABC protein complex.

PubMed

Dong, Ming; Gonzalez, Tara D; Klems, Meghan M; Steinberg, Lisa M; Chen, Wilfred; Papoutsakis, Eleftherios T; Bahnson, Brian J

2017-09-01

Methanol:coenzyme M methyltransferase is an enzyme complex composed of three subunits, MtaA, MtaB, and MtaC, found in methanogenic archaea and is needed for their growth on methanol ultimately producing methane. MtaABC catalyzes the energetically favorable methyl transfer from methanol to coenzyme M to form methyl coenzyme M. Here we demonstrate that this important reaction for possible production of methanol from the anaerobic oxidation of methane can be reversed in vitro. To this effect, we have expressed and purified the Methanosarcina barkeri MtaABC enzyme, and developed an in vitro functional assay that demonstrates MtaABC can catalyze the energetically unfavorable (ΔG° = 27 kJ/mol) reverse reaction starting from methyl coenzyme M and generating methanol as a product. Demonstration of an in vitro ability of MtaABC to produce methanol may ultimately enable the anaerobic oxidation of methane to produce methanol and from methanol alternative fuel or fuel-precursor molecules. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 33:1243-1249, 2017. © 2017 American Institute of Chemical Engineers.

7 CFR 900.407 - Confidential information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... the Conduct of Referenda in Connection With Marketing Orders for Fruits, Vegetables, and Nuts Pursuant to the Agricultural Marketing Agreement Act of 1937, as Amended § 900.407 Confidential information...

7 CFR 900.407 - Confidential information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... the Conduct of Referenda in Connection With Marketing Orders for Fruits, Vegetables, and Nuts Pursuant to the Agricultural Marketing Agreement Act of 1937, as Amended § 900.407 Confidential information...

7 CFR 900.407 - Confidential information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... the Conduct of Referenda in Connection With Marketing Orders for Fruits, Vegetables, and Nuts Pursuant to the Agricultural Marketing Agreement Act of 1937, as Amended § 900.407 Confidential information...

7 CFR 900.407 - Confidential information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... the Conduct of Referenda in Connection With Marketing Orders for Fruits, Vegetables, and Nuts Pursuant to the Agricultural Marketing Agreement Act of 1937, as Amended § 900.407 Confidential information...

7 CFR 993.71 - Confidential information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Confidential information. 993.71 Section 993.71 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE DRIED PRUNES PRODUCED IN...

7 CFR 993.71 - Confidential information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Confidential information. 993.71 Section 993.71 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE DRIED PRUNES PRODUCED IN...

7 CFR 993.71 - Confidential information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 8 2014-01-01 2014-01-01 false Confidential information. 993.71 Section 993.71 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE DRIED PRUNES PRODUCED IN...

7 CFR 993.71 - Confidential information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 8 2012-01-01 2012-01-01 false Confidential information. 993.71 Section 993.71 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE DRIED PRUNES PRODUCED IN...

7 CFR 929.65 - Confidential information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Confidential information. 929.65 Section 929.65 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES OF...

7 CFR 929.65 - Confidential information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Confidential information. 929.65 Section 929.65 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES OF...

7 CFR 929.65 - Confidential information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 8 2014-01-01 2014-01-01 false Confidential information. 929.65 Section 929.65 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES OF...

7 CFR 929.65 - Confidential information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 8 2012-01-01 2012-01-01 false Confidential information. 929.65 Section 929.65 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES OF...

Radiopacity evaluation of Portland and MTA-based cements by digital radiographic system.

PubMed

Borges, Alvaro Henrique; Pedro, Fabio Luiz Miranda; Semanoff-Segundo, Alex; Miranda, Carlos Eduardo Saraiva; Pécora, Jesus Djalma; Cruz Filho, Antônio Miranda

2011-01-01

The aim of the present study was to evaluate the radiopacity of Portland and MTA-based cements using the Digora TM digital radiographic system. The performed tests followed specification number 57 from the American National Standard Institute/American Dental Association (2000) for endodontic sealing materials. The materials were placed in 5 acrylic plates, especially designed for this experiment, along with a graduated aluminum stepwedge varying from 1 to 10 mm in thickness. The set was radiographed at a 30 cm focus-object distance and with 0.2 s exposure time. After the radiographs were taken, the optical laser readings of radiographs were performed by Digora TM system. Five radiographic density readings were performed for each studied material and for each step of the aluminum scale. White ProRoot MTA (155.99±8.04), gray ProRoot MTA (155.96±16.30) and MTA BIO (143.13±16.94) presented higher radiopacity values (p<0.05), while white non-structural Portland (119.76±22.34), gray Portland (109.71±4.90) and white structural Portland (99.59±12.88) presented lower radiopacity values (p<0.05). It was concluded that MTA-based cements were the only materials presenting radiopacity within the ANSI/ADA specifications.

15 CFR 701.5 - Confidentiality.

Code of Federal Regulations, 2011 CFR

2011-01-01

... OFFSETS AGREEMENTS IN SALES OF WEAPON SYSTEMS OR DEFENSE-RELATED ITEMS TO FOREIGN COUNTRIES OR FOREIGN FIRMS § 701.5 Confidentiality. (a) As provided by § 309(c) of the Defense Production Act of 1950, as... disclosure must be authorized in writing by an official of the firm competent to make such an authorization...

Radiopacity evaluation of Portland and MTA-based cements by digital radiographic system

PubMed Central

BORGES, Alvaro Henrique; PEDRO, Fabio Luiz Miranda; SEMANOFF-SEGUNDO, Alex; MIRANDA, Carlos Eduardo Saraiva; PÉCORA, Jesus Djalma; CRUZ FILHO, Antônio Miranda

2011-01-01

Objective The aim of the present study was to evaluate the radiopacity of Portland and MTA-based cements using the Digora TM digital radiographic system. Material and Methods The performed tests followed specification number 57 from the American National Standard Institute/American Dental Association (2000) for endodontic sealing materials. The materials were placed in 5 acrylic plates, especially designed for this experiment, along with a graduated aluminum stepwedge varying from 1 to 10 mm in thickness. The set was radiographed at a 30 cm focus-object distance and with 0.2 s exposure time. After the radiographs were taken, the optical laser readings of radiographs were performed by Digora TM system. Five radiographic density readings were performed for each studied material and for each step of the aluminum scale. Results White ProRoot MTA (155.99±8.04), gray ProRoot MTA (155.96±16.30) and MTA BIO (143.13±16.94) presented higher radiopacity values (p<0.05), while white non-structural Portland (119.76±22.34), gray Portland (109.71±4.90) and white structural Portland (99.59±12.88) presented lower radiopacity values (p<0.05). Conclusions It was concluded that MTA-based cements were the only materials presenting radiopacity within the ANSI/ADA specifications. PMID:21625738

Photo-Induced depopulation of the 180mTa isomer

NASA Astrophysics Data System (ADS)

Bhike, Megha; Krishichayan, Fnu; Tornow, W.

2015-10-01

The 180mTa nucleus is the rarest isotope in the universe, existing only in an isomeric state at 77.2 keV (Jπ = 9-) with half-life of greater than 7.1 ×1015 years. The stellar production of this high-spin isomer has been a challenging astrophysical problem. Cross-section measurements for the depopulation of the 180mTa isomer with monoenergetic photon beams of energies 2.5 and 3.1 MeV have been carried out at the HI γS facility. The activated Ta foils of natural abundance and containing 14.4 mg of 180mTa were γ-ray counted at TUNL's low background facility using a 13% planar HPGe detector. A 8'' ×12'' NaI detector in combination with the standard HI γS scintillator paddle system was employed for absolute photon-flux determination. Preliminary results will be discussed, and measurements at lower energies are planned. This work was supported by the U.S. DOE under Grant NO. DE-FG02-97ER41033.

12 CFR 1070.47 - Other rules regarding the disclosure of confidential information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... the requestor is a legislative body, use its best efforts to obtain the commitment or agreement of the legislative body that it will maintain the confidentiality of the confidential information. (5) No person... in possession of such information except as permitted by specific language in this regulation or by...

12 CFR 1070.47 - Other rules regarding the disclosure of confidential information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... the requestor is a legislative body, use its best efforts to obtain the commitment or agreement of the legislative body that it will maintain the confidentiality of the confidential information. (5) No person... in possession of such information except as permitted by specific language in this regulation or by...

The effect of MTA application on the affected dentine remineralization after partial caries excavation (in vivo)

NASA Astrophysics Data System (ADS)

Pratiwi, A. R.; Meidyawati, R.; Djauharie, N.

2017-08-01

On deep carious lesions, only thin dentine remains, causing a high risk of pulp exposure during the removal of all infected dentine. A minimally invasive technique is required, such as a partial caries excavation method in the infected dentine tissue and the use of bioactive material that can promote (Mineral Trioxide Aggregate) MTA remineralization. To compare the remineralization of deep carious lesion-affected dentine with the removal of some and all the infected dentine after the application of MTA. Subjects were divided into two groups: group I had only some parts of the infected dentine removed before MTA application, while group II had all the infected dentine removed before MTA application. Each group was measured on the pixel grey value before the treatment and again four weeks after the MTA application, and then the results were compared. Furthermore, the enhancement of both groups’ grey values were compared. Remineralization occurred in both groups after the MTA application. There was no significant difference in the remineralization level of the affected dentine in both groups I and II four weeks after the MTA application. Remineralization occurred in the affected dentine in both groups, either by removing only some parts or all the infected dentine in the deep carious lesion.

Physical, chemical, and biological properties of white MTA with additions of AlF3.

PubMed

Marciano, Marina Angélica; Camilleri, Josette; Lucateli, Ribamar Lazanha; Costa, Reginaldo Mendonça; Matsumoto, Mariza Akemi; Duarte, Marco Antonio Hungaro

2018-04-13

Addition of aluminum fluoride (AlF 3 ) to MTA was tested to inhibit dental discoloration. MTA Angelus with 0, 5, 15, and 45% AlF 3 were tested. The set cements were characterized using scanning electron microscopy, energy-dispersive spectroscopy, and X-ray diffraction. Radiopacity and setting time were analyzed according to ANSI/ADA 57 and ASTM C266-08. Volume change was evaluated using volumetric micro-CT analysis. The pH and calcium ion release were assessed after 3 and 24 h and 28 days. Dental discoloration in contact with the cements was assessed after 24 h and 28 and 90 days of contact with bovine and human dentine. Tissue reaction to subcutaneous implantation in rats was examined after 30 and 60 days. AlF 3 altered the microstructure of MTA. The addition of 5% AlF 3 did not significantly alter the radiopacity, setting time, and volume change (p > 0.05). pH and calcium ion release significantly increased with addition of AlF 3 (p > 0.05). All the tested proportions of AlF 3 prevented the dental darkening verified for MTA Angelus in bovine and human teeth. AlF 3 did not interfere in inflammatory response of MTA in all periods of analysis; otherwise, lower amounts showed less intense inflammatory infiltrate. AlF 3 prevents destabilization of bismuth oxide and consequent tooth darkening, frequently verified in clinical practice when using white MTA. The use of 5% of AlF 3 in combination to MTA resulted in a cement that did not result in dental discoloration and did not affect significantly physical, chemical, and biological properties.

Root End Generation: An Unsung Characteristic Property of MTA-A Case Report

PubMed Central

Dixit, Seema; Dixit, Ashutosh; Kumar, Pravin; Arora, Saurabh

2014-01-01

Management of immature teeth with necrotic pulp and periapical lesion has long presented a challenge. The treatment of choice for such teeth is apexification, which is induction of apical closure to produce more favorable conditions for conventional canal obturation. Traditionally, calcium hydroxide has been used for the apexification of immature permanent teeth, however, Mineral Trioxide Aggregate (MTA) holds significant promise not only as an alternative to multiple treatment visits with calcium hydroxide but also having the potential to induce root end development, eventually forming a completed root apex. This case report presents a successful healing and apexification with the use of calcium hydroxide and MTA. A 5-year follow-up revealed root development with MTA. PMID:24596800

Histological and histomorphometrical evaluation of furcation perforations filled with MTA, CPM and ZOE.

PubMed

da Silva, G F; Guerreiro-Tanomaru, J M; Sasso-Cerri, E; Tanomaru-Filho, M; Cerri, P S

2011-02-01

To evaluate the biological response of the periodontium adjacent to furcation perforations in rat molars filled with Endo-CPM-Sealer (CPM), MTA-Angelus (MTA) or zinc oxide-eugenol cement (ZOE). The pulp chamber floors of maxillary right first molar teeth were perforated and sealed with CPM, mineral trioxide aggregate (MTA) or ZOE; the left first molars, without any treatment, were used as controls (CG). After 7, 15, 30 and 60 days, fragments of maxilla were fixed, decalcified and embedded in paraffin. Sections were stained with H&E, Masson's trichrome and submitted to tartrate-resistant acid phosphatase (TRAP) reaction, used as an osteoclast marker. The width of the periodontal space, the numerical density of inflammatory cells and the number of TRAP-positive osteoclasts in the bone surface were measured, and statistical analyses were performed using analysis of variance and Tukey test (P ≤ 0.05). In all experimental groups, the greatest number of inflammatory cells was observed at 7 days, especially in the ZOE group. In this group, the intense inflammatory process was related to a significant increase (P ≤ 0.05) in the number of osteoclasts and, thereby, in an increase in the width of the periodontal space. At 60 days, no significant differences in osteoclast numbers amongst CPM, MTA and CG groups occurred; the periodontal space was also significantly reduced in the experimental groups in comparison with the initial periods. However, in the ZOE group, the periodontal space was significantly larger (P ≤ 0.05) in comparison with MTA-based materials. The periodontium adjacent to perforations filled with MTA and CPM exhibited clear evidence of re-establishment and thus better biocompatibility than ZOE. © 2010 International Endodontic Journal.

Resveratrol regulates PTEN/Akt pathway through inhibition of MTA1/HDAC unit of the NuRD complex in prostate cancer.

PubMed

Dhar, Swati; Kumar, Avinash; Li, Kun; Tzivion, Guri; Levenson, Anait S

2015-02-01

Metastasis associated protein 1 (MTA1) is a component of the nucleosome remodeling and deacetylating (NuRD) complex which mediates gene silencing and is overexpressed in several cancers. We reported earlier that resveratrol, a dietary stilbene found in grapes, can down-regulate MTA1. In the present study, we show that PTEN is inactivated by MTA1 in prostate cancer cells. Further, we show that resveratrol promotes acetylation and reactivation of PTEN via inhibition of the MTA1/HDAC complex, resulting in inhibition of the Akt pathway. In addition, we show that MTA1 knockdown is sufficient to augment acetylation of PTEN indicating a crucial role of MTA1 itself in the regulation of PTEN acetylation contributing to its lipid phosphatase activity. Acetylated PTEN preferentially accumulates in the nucleus where it binds to MTA1. We also show that MTA1 interacts exclusively with PTEN acetylated on Lys¹²⁵ and Lys¹²⁸, resulting in diminished p-Akt levels. Finally, using orthotopic prostate cancer xenografts, we demonstrate that both resveratrol treatment and MTA1 knockdown enhance PTEN levels leading to a decreased p-Akt expression and proliferation index. Taken together, our results indicate that MTA1/HDAC unit is a negative regulator of PTEN which facilitates survival pathways and progression of prostate cancer and that resveratrol can reverse this process through its MTA1 inhibitory function. Copyright © 2014 Elsevier B.V. All rights reserved.

Influence of 2% chlorhexidine on pH, calcium release and setting time of a resinous MTA-based root-end filling material.

PubMed

Jacinto, Rogério Castilho; Linhares-Farina, Giane; Sposito, Otávio da Silva; Zanchi, César Henrique; Cenci, Maximiliano Sérgio

2015-01-01

The addition of chlorhexidine (CHX) to a resinous experimental Mineral Trioxide Aggregate (E-MTA) based root-end filling material is an alternative to boost its antimicrobial activity. However, the influence of chlorhexidine on the properties of this material is unclear. The aim of this study was to evaluate the influence of 2% chlorhexidine on the pH, calcium ion release and setting time of a Bisphenol A Ethoxylate Dimethacrylate/Mineral Trioxide Aggregate (Bis-EMA/MTA) based dual-cure experimental root-end filling material (E-MTA), in comparison with E-MTA without the addition of CHX and with conventional white MTA (W-MTA). The materials were placed in polyethylene tubes, and immersed in deionized water to determine pH (digital pH meter) and calcium ion release (atomic absorption spectrometry technique). The setting time of each material was analyzed using Gilmore needles. The data were statistically analyzed at a significance level of 5%. E-MTA + CHX showed an alkaline pH in the 3 h period of evaluation, the alkalinity of which decreased but remained as such for 15 days. The pH of E-MTA + CHX was higher than the other two materials after 7 days, and lower after 30 days (p < 0.05). All of the materials were found to release calcium ions throughout the 30 days of the study. The addition of CHX increased the calcium ion release of E-MTA to levels statistically similar to W-MTA. E-MTA showed shorter initial and final setting time, compared with W-MTA (p < 0.05). The addition of 2% CHX to MTA prevented setting of the material. The addition of CHX to E-MTA increased its pH and calcium ion release. However, it also prevented setting of the material.

[An 18 month evaluation of MM-MTA pulpotomy on primary decayed molars].

PubMed

Abou Chedid, J C; Mchayleh, N; Khalil, I; Melki, B; Hardan, L S

2015-12-01

Pulpotomy is the most performed and controversial therapeutic in pediatric dentistry. Formocresol is known to have a toxic effect on living tissues, a mutagenic and carcinogenic potential with a systemic uptake of formocresol via pulpotomized teeth, other alternative products have been investigated. 40 molars were pulpotomized using Micro Mega Mineral Trioxide Aggregate (MM-MTA), which eliminates the need for the use of formocresol. The effects of this material were evaluated both clinically and radiographically. Post-operative control examinations were performed at 1, 6, 12, and 18 months trying to detect spontaneous or stimulated pain, pathological tooth mobility, abscesses or fistulas, internal or external pathological tooth resorption, periapical bone destruction, or canal obliteration. Pain was absent at 18 months post operatively. Thirty six molar treated with the MM-MTA didn't show any mobility or pain, one molar presented a pathological resorption and one molar presented an abscess without a fistula at 12 month. The observations were compared to others related to formocresol, ferric sulfate, MTA, and laser pulpotomies, using the Chi-square test x2. The abundance of positive result strongly demonstrate that the MM-MTA pulpotomy on carious temporary molars is a promising technique.

Sealing ability of mineral trioxide aggregate (MTA) combined with distilled water, chlorhexidine, and doxycycline.

PubMed

Arruda, Roberta A A; Cunha, Rodrigo S; Miguita, Kenner B; Silveira, Cláudia F M; De Martin, Alexandre S; Pinheiro, Sérgio L; Rocha, Daniel G P; Bueno, Carlos E S

2012-09-01

The aim of this study was to evaluate the sealing ability of mineral trioxide aggregate (MTA Bio) combined with different mixing agents (distilled water, chlorhexidine, doxycycline), used as an apical root-end filling material. Forty-two extracted human teeth were divided into three groups (n = 12); six teeth were used as controls. Root-ends were resected at 90 degrees, 3 mm from the apex. Root-end cavities were prepared using ultrasonic tips and filled with MTA Bio plus distilled water, 2% chlorhexidine solution, or 10% doxycycline solution. Apical sealing was assessed by microleakage of 50% silver nitrate solution. Roots were longitudinally sectioned in a buccolingual plane and analyzed using an operating microscope (20× magnification). Depth of dye leakage into the dentinal walls was measured in millimeters. Results were analyzed using ANOVA and Tukey's test (P = 0.05). MTA Bio plus distilled water showed significantly higher mean leakage results (1.06 mm) when compared with MTA Bio plus doxycycline (0.61 mm), and higher, although not significant, results when compared with MTA Bio plus chlorhexidine (0.79 mm). In conclusion, replacing distilled water with two biologically active mixing agents (doxycycline and chlorhexidine) did not alter the sealing properties of MTABio. The antimicrobial properties of these combinations should be further investigated.

Analysis of Metal Contents in Portland Type V and MTA-Based Cements

PubMed Central

Dorileo, Maura Cristiane Gonçales Orçati; Bandeca, Matheus Coelho; Pedro, Fábio Luis Miranda; Volpato, Luiz Evaristo Ricci; Guedes, Orlando Aguirre; Villa, Ricardo Dalla; Tonetto, Mateus Rodrigues; Borges, Alvaro Henrique

2014-01-01

The aim of this study was to determine, by Atomic Absorption Spectrometry (AAS), the concentration levels of 11 metals in Type V gray and structural white PC, ProRoot MTA, and MTA Bio. Samples, containing one gram of each tested cement, were prepared and transferred to a 100 mL Teflon tube with a mixture of 7.0 mL of nitric acid and 21 mL of hydrochloric acid. After the reaction, the mixture was filtered and then volumed to 50 mL of distilled water. For each metal, specific patterns were determined from universal standards. Arsenic quantification was performed by hydride generator. The analysis was performed five times and the data were statistically analyzed at 5% level of significance. Only the cadmium presented concentration levels of values lower than the quantification limit of the device. The AAS analysis showed increased levels of calcium, nickel, and zinc in structural white PC. Type V PC presented the greatest concentration levels of arsenic, chromium, copper, iron, lead, and manganese (P < 0.05). Bismuth was found in all cements, and the lowest concentration levels were observed in Portland cements, while the highest were observed in ProRoot MTA. Both PC and MTA-based cements showed evidence of metals inclusion. PMID:25436238

A simplified technique of orthograde MTA obturation on the elected canals of posterior teeth: Two case reports.

PubMed

Wahengbam, Brucelee; Wahengbam, Pragya; Tikku, Aseem Prakash

2014-01-01

This article suggests a simplified technique of orthograde MTA obturation in less accessible canal(s) of posteriors teeth without using costly ultrasonics or specialised carrier. Essentially few finger pluggers, absorbent points and a simple canal projection method were used. The orifice(s) of the elected canal(s) to be obturated with MTA were projected onto the external occlusal surface for easy delivery and predictive instrumentation. The idea was based on 'easy access', 'working one canal with one mix at one time', 'thorough condensation' and 'removal of excess moisture'. In case I, palatal canal of tooth no. 2 with gross apical perforation and suspected VRF was obturated with MTA. And in Case II, tooth no. 19 presented with incomplete furcal fracture extending into the canal was obturated with MTA in all 3 canals unitarily. Dense homogenous MTA obturation was achieved and both cases healed uneventfully.

7 CFR 983.9 - Confidential data or information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential data or information. 983.9 Section 983.9 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE PISTACHIOS GROWN IN CALIFORNIA...

Dietary Pterostilbene is a novel MTA1-targeted chemopreventive and therapeutic agent in prostate cancer

USDA-ARS?s Scientific Manuscript database

Dietary nutrients with ability to reverse adverse epigenetic events have great potential for cancer chemoprevention. Overexpression of the epigenetic modifier metastasis-associated protein 1 (MTA1) is associated with aggressive human prostate cancer. The purpose of this study was to determine MTA1-d...

Composition and microstructure of MTA and Aureoseal Plus: XRF, EDS, XRD and FESEM evaluation.

PubMed

Cianconi, L; Palopoli, P; Campanella, V; Mancini, M

2016-12-01

The aim of this study was to determine the chemical composition and the phases' microstructure of Aureoseal Plus (OGNA, Italy) and ProRoot MTA (Dentsply Tulsa Dental, USA) and to compare their characteristics. Study Design: Comparing Aureoseal Plus and ProRoot MTA microstructure by means of several analyses type. The chemical analysis of the two cements was assessed following the UNI EN ISO 196-2 norm. X-Ray fluorescence (XRF) was used to determine the element composition. The crystalline structure was analysed quantitatively using x-ray diffraction (XRD). Powders morphology was evaluated using a scanning electron microscope (SEM) with backscattering detectors, and a field emission scanning electron microscope (FESEM). Elemental analysis was performed by energy dispersive x-ray analysis (EDS). The semi-quantitative XRF analysis showed the presence of heavy metal oxides in both cements. The XRD spectra of the two cements reported the presence of dicalcium silicate, tricalcium silicate, tricalcium aluminate, tetracalcium aluminoferrite, bismuth oxide and gypsum. SEM analysis showed that ProRoot MTA powder is less coarse and more homogeneous than Aureoseal. Both powders are formed by particles of different shapes: round, prismatic and oblong. The EDS analysis showed that some ProRoot MTA particles, differently from Aureoseal, contain Ca, Si, Al and Fe. Oblong particles in ProRoot and Aureoseal are rich of bismuth. The strong interest in developing new Portland cement-based endodontic sealers will create materials with increased handling characteristics and physicochemical properties. A thorough investigation on two cement powders was carried out by using XRF, XRD, SEM and EDS analysis. To date there was a lack of studies on Aureoseal Plus. This cement is similar in composition to ProRoot MTA. Despite that it has distinctive elements that could improve its characteristics, resulting in a good alternative to MTA.

Effect of Nd: YAG laser on the apical seal after root-end resection and MTA retrofill: a bacterial leakage study.

PubMed

Birang, Reza; Kiani, Sepideh; Shokraneh, Ali; Hasheminia, Seyed Mohsen

2015-02-01

Laser irradiation has been investigated in terms of preventing leakage in retrofilled root canals. The aim of the present study was to evaluate the effect of neodymium-doped yttrium aluminum garnet (Nd: YAG) laser on the bacterial leakage of mineral trioxide aggregate (MTA)-retrofilled roots. In this ex vivo experimental study, 90 single-rooted incisor teeth were filled with gutta-percha and AH26 sealer. The apical 3 mm of all the roots were resected and 3-mm retrocavities were prepared by an ultrasonic device. The specimens were randomly divided into two experimental (n = 25), one positive control (n = 10), and two negative control (n = 10) groups. In the laser + MTA group, the cavity walls were irradiated by Nd: YAG laser prior to MTA placement. In the MTA group, MTA was placed without laser irradiation. The root surfaces were covered with two layers of nail varnish except for the apical 2 mm. The specimens were then embedded in a bacterial leakage test system and examined daily for 90 days. Contamination periods were recorded. Data were analyzed by Kaplan-Meier and Mann-Whitney U tests (α = 0.05). Five teeth with and five teeth without laser irradiation underwent scanning electron microscopic evaluation. The specimens in the laser + MTA group were contaminated earlier than those in the MTA group (p < 0.05). Comparison of survival times between the two groups showed significant differences (p < 0.05). Nd: YAG laser irradiation can decrease the sealing capacity of MTA in comparison to the apical seal achieved by MTA without laser irradiation. Further studies are recommended to provide a better seal for the MTA-retrofilled teeth after laser irradiation.

Dental discoloration caused by bismuth oxide in MTA in the presence of sodium hypochlorite.

PubMed

Marciano, Marina Angélica; Duarte, Marco Antonio Hungaro; Camilleri, Josette

2015-12-01

The aim of this research was to analyse the dental discolouration caused by mineral trioxide aggregate (MTA) induced by bismuth oxide and also assess the colour stability of other dental cements. Bismuth oxide, calcium tungstate and zirconium oxide were placed in contact with sodium hypochlorite for 24 h after which they were dried and photographed. Phase analyses were performed by X-ray diffraction (XRD) of radiopacifiers before and after immersion in sodium hypochlorite. Furthermore, teeth previously immersed in water or sodium hypochlorite were filled with MTA Angelus, Portland cement (PC), PC with 20 % zirconium oxide, PC with 20 % calcium tungstate and Biodentine. Teeth were immersed for 28 days in Hank's balanced salt solution after which they were sectioned and characterized using scanning electron microscopy (SEM) with energy-dispersive mapping and stereomicroscopy. Bismuth oxide in contact with sodium hypochlorite exhibited a change in colour from light yellow to dark brown. XRD analysis demonstrated peaks for radiopacifier and sodium chloride in samples immersed in sodium hypochlorite. The SEM images of the dentine to material interface showed alteration in material microstructure for MTA Angelus and Biodentine with depletion in calcium content in the material. The energy-dispersive maps showed migration of radiopacifier and silicon in dentine. MTA Angelus in contact with a tooth previously immersed in sodium hypochlorite resulted in colour alteration at the cement/dentine interface. MTA Angelus should not be used after irrigation with sodium hypochlorite as this will result in tooth discoloration.

Orthograde retreatment failure with extruded MTA apical plug in a large periradicular lesion followed by surgical intervention: case report.

PubMed

Brito-Junior, Manoel; Faria-e-Silva, Andre Luis; Quintino, Alex Carvalho; Moreira-Junior, Gil; Geber, Mauro; Camilo, Carla Cristina; Soares, Janir Alves

2012-01-01

Absence of periapical healing after orthograde retreatment using an apical plug with mineral trioxide aggregate (MTA) can require surgical intervention. A patient with a root-filled maxillary central incisor with chronic apical periodontitis and sinus tract was referred for endodontic retreatment. Excessive apical enlargement was verified, indicating an MTA apical plug placement; however, an unintentional extrusion of MTA occurred during this step. The root canal was filled with gutta-percha and sealer, and periodic recalls were scheduled. The sinus tract was observed after six months and the lesion remained unaltered, although the extruded MTA had resorbed; therefore, an apicoectomy and retrograde root-end filling with MTA were performed. Absence of sinus tract, normal clinical aspect, and complete repair of the lesion were observed at the two-year follow-up.

Material Transfer Agreement (MTA) | Frederick National Laboratory for Cancer Research

Cancer.gov

Material Transfer Agreements are appropriate for exchange of materials into or out of the Frederick National Laboratory for research or testing purposes, with no collaborative research by parties involving the materials.

Psychotic Symptoms in Attention-Deficit/Hyperactivity Disorder: An Analysis of the MTA Database.

PubMed

Vitiello, Benedetto; Perez Algorta, Guillermo; Arnold, L Eugene; Howard, Andrea L; Stehli, Annamarie; Molina, Brooke S G

2017-04-01

To assess the prevalence of psychotic symptoms among youths (14-25 years of age) with a childhood diagnosis of attention-deficit/hyperactivity disorder (ADHD) combined type. Participants in the Multimodal Treatment Study of Children with ADHD (MTA) and a local normative comparison group (LNCG) were systematically assessed 6, 8, 10, 12, 14, and 16 years after the original enrollment at a mean age of 8.5 years. Trained research assistants administered a psychosis screener, and positive screens were referred to study clinicians to confirm or exclude psychosis. Possible associations between screening positive and alcohol or substance use were assessed. Data were available from 509 MTA participants (88% of original MTA sample; mean age 25.1 years) and 276 LNCG participants (96% of original sample; mean age 24.6 years) at year 16. Twenty-six MTA participants (5%; 95% CI 3-7) and 11 LNCG participants (4%; 95% CI 2-6) screened positive for at least 1 psychotic symptom (p = .60). Most psychotic symptoms were transient. The prevalence of clinician-confirmed psychotic symptoms was 1.1% (95% CI 0.2-2.1) in the MTA group and 0.7% (0-1.7) in the LNCG (p = .72). Greater cannabis use was reported by those who screened positive (p < .05) and were confirmed positive (p < .01). There was no evidence that ADHD increased the risk for psychotic symptoms. In the ADHD and normative comparison groups, more frequent cannabis use was associated with a greater likelihood of experiencing psychotic symptoms, thus supporting the recommendation that youth should not use cannabis. Published by Elsevier Inc.

Psychotic Symptoms in Attention-Deficit/Hyperactivity Disorder: An Analysis of the MTA Database

PubMed Central

Vitiello, Benedetto; Algorta, Guillermo Perez; Arnold, L. Eugene; Howard, Andrea L.; Stehli, Annamarie; Molina, Brooke S.G.

2017-01-01

Objective To assess the prevalence of psychotic symptoms among youths (age 14-25 years) with a childhood diagnosis of attention-deficit/hyperactivity disorder (ADHD) combined type. Method The participants in the Multimodal Treatment Study of Children with ADHD (MTA) and a local normative comparison group (LNCG) were systematically assessed 6, 8, 10, 12, 14, and 16 years after the original enrollment at a mean age of 8.5 years. Trained research assistants administered a psychosis screener, and positive screens were referred to study clinicians to confirm or exclude psychosis. Possible associations between screening positive and alcohol or substance use were assessed. Results Data were available from 509 MTA participants (88% of the original MTA sample) and 276 LNCG participants (96% of the original sample), with a mean age of 25.1 and 24.6 years, respectively, at year 16. Twenty-six MTA participants (5%, 95% CI: 3, 7) and 11 LNCG (4%, 95% CI: 2, 6) screened positive for at least one psychotic symptom (p=.60). Most psychotic symptoms were transient. The prevalence of clinician-confirmed psychotic symptoms was 1.1% (95% CI 0.2, 2.1) in the MTA and 0.7% (0, 1.7) in the LNCG (p=.72). Greater cannabis use was reported by those who screened (p<.05) and were confirmed positive (p<.01). Conclusion There was no evidence that ADHD increased the risk for psychotic symptoms. In both the ADHD and normative comparison groups, more frequent cannabis use was associated with greater likelihood of experiencing psychotic symptoms, thus supporting the recommendation that youth should not use cannabis. PMID:28335878

Solubility and bacterial sealing ability of MTA and root-end filling materials.

PubMed

Espir, Camila Galletti; Guerreiro-Tanomaru, Juliane Maria; Spin-Neto, Rubens; Chávez-Andrade, Gisselle Moraima; Berbert, Fabio Luiz Camargo Villela; Tanomaru-Filho, Mario

2016-04-01

Objective To evaluate solubility and sealing ability of Mineral Trioxide Aggregate (MTA) and root-end filling materials. Material and Methods The materials evaluated were: MTA, Calcium Silicate Cement with zirconium oxide (CSC/ZrO2), and zinc oxide/eugenol (ZOE). Solubility test was performed according to ANSI/ADA. The difference between initial and final mass of the materials was analyzed after immersion in distilled water for 7 and 30 days. Retrograde cavities in human teeth with single straight root canal were performed by using ultrasonic tip CVD 9.5107-8. The cavities were filled with the evaluated materials to evaluate sealing ability using the bacterial leakage test with Enterococcus faecalis. Bacterial leakage was evaluated every 24 hours for six weeks observing the turbidity of Brain Heart infusion (BHI) medium in contact with root apex. Data were submitted to ANOVA followed by Tukey tests (solubility), and Kruskal-Wallis and Dunn tests (sealing ability) at a 5% significance level. Results For the 7-day period, ZOE presented highest solubility when compared with the other groups (p<0.05). For the 30-day period, no difference was observed among the materials. Lower bacterial leakage was observed for MTA and CSC/ZrO2, and both presented better results than ZOE (p<0.05). Conclusion MTA and CSC/ZrO2 presented better bacterial sealing capacity, which may be related to lower initial solubility observed for these materials in relation to ZOE.

Clinical study of Mineral Trioxide Aggregate in primary molars. Comparison between Grey and White MTA--a long term follow-up (84 months).

PubMed

Cardoso-Silva, Cristina; Barbería, Elena; Maroto, Myriam; García-Godoy, Franklin

2011-02-01

The aim of the present study was to conduct a clinical and radiographic long-term evaluation of pulpotomy in temporary molars performed with Grey and White Mineral Trioxide Aggregate (MTA) and compare the results of Grey and White MTA pulpotomies in a sample of 233 primary molars with a maximum follow-up period of 84 months. The sample was selected from patients treated at the Department of Pediatric Dentistry, Faculty of Dentistry, Complutense University of Madrid, Spain. This prospective study included first and second primary molars treated with pulpotomy with Grey or White MTA, controlled for a maximum follow-up period of 84 months. Statistical analysis of clinical and radiographic findings was completed using ANOVA (P<0.05). Follow-up evaluations, performed every 6 months, revealed that only 2 molars treated with White MTA presented abscess and pathological mobility. Radiographic examination of the 210 molars revealed unfavourable pulp response in only 6 molars (internal or furcation root resorption), without statistically significant differences between Grey and White MTA. Two radiological findings were noticed: dentine bridge formation and partial or total root canal stenosis. Grey MTA induced a higher percentage of dentine bridges with statistically significant differences (P<0.05), and a higher percentage of pulp canal stenosis, without a statistically significant difference. Grey and White MTA presented high levels of clinical and radiographic success. Although the present study showed evidence of a very good biologic response with both types of MTA, Grey MTA showed significantly higher number of dentine bridge formation than White MTA. Copyright © 2010 Elsevier Ltd. All rights reserved.

Cytotoxicity and Initial Biocompatibility of Endodontic Biomaterials (MTA and Biodentine™) Used as Root-End Filling Materials.

PubMed

Escobar-García, Diana María; Aguirre-López, Eva; Méndez-González, Verónica; Pozos-Guillén, Amaury

2016-01-01

Objective. The aim of this study was to evaluate the cytotoxicity and cellular adhesion of Mineral Trioxide Aggregate (MTA) and Biodentine (BD) on periodontal ligament fibroblasts (PDL). Methods. PDL cells were obtained from nonerupted third molars and cultured; MTS cellular profusion test was carried out in two groups: MTA and BD, with respective controls at different time periods. Also, the LIVE/DEAD assay was performed at 24 h. For evaluation of cellular adhesion, immunocytochemistry was conducted to discern the expression of Integrin β1 and Vinculin at 12 h and 24 h. Statistical analysis was performed by the Kruskal-Wallis and Mann-Whitney U tests. Results. MTA and BD exhibited living cells up to 7 days. More expressions of Integrin β1 and Vinculin were demonstrated in the control group, followed by BD and MTA, which also showed cellular loss and morphological changes. There was a significant difference in the experimental groups cultured for 5 and 7 days compared with the control, but there was no significant statistical difference between both cements. Conclusions. Neither material was cytotoxic during the time evaluated. There was an increase of cell adhesion through the expression of focal contacts observed in the case of BD, followed by MTA, but not significantly.

Sealing ability of MTA, CPM, and MBPc as root-end filling materials: a bacterial leakage study.

PubMed

Medeiros, Paulo Leal; Bernardineli, Norberti; Cavenago, Bruno Cavalini; Torres, Sérgio Aparecido; Duarte, Marco Antonio Hungaro; Bramante, Clovis Monteiro; Marciano, Marina Angélica

2016-04-01

Objectives To evaluate the sealing ability of three root-end filling materials (white MTA, CPM, and MBPc) using an Enterococcus faecalis leakage model. Material and Methods Seventy single-root extracted human teeth were instrumented and root-ends were resected to prepare 3 mm depth cavities. Root-end preparations were filled with white MTA, CPM, and MBPc cements. Enterococcus faecalis was coronally introduced and the apical portion was immersed in BHI culture medium with phenol red indicator. The bacterial leakage was monitored every 24 h for 4 weeks. The statistical analysis was performed using the Wilcoxon-Gehan test (p<0.05). Results All cements showed bacterial leakage after 24 hours, except for the negative control group. The MBPc showed significantly less bacterial leakage compared with the MTA group (p<0.05). No significant differences were found between the CPM and the other groups. Conclusions The epoxy resin-based cement MBPc had lower bacterial leakage compared with the calcium silicate-based cements MTA and CPM.

The metastasis-associated gene MTA3, a component of the Mi-2/NuRD transcriptional repression complex, predicts prognosis of gastroesophageal junction adenocarcinoma.

PubMed

Dong, Hongmei; Guo, Hong; Xie, Liangxi; Wang, Geng; Zhong, Xueyun; Khoury, Thaer; Tan, Dongfeng; Zhang, Hao

2013-01-01

Gastroesophageal junction (GEJ) adenocarcinoma carries a poor prognosis that is largely attributable to early and frequent metastasis. The acquisition of metastatic potential in cancer involves epithelial-to-mesenchymal transition (EMT). The metastasis-associated gene MTA3, a novel component of the Mi-2/NuRD transcriptional repression complex, was identified as master regulator of EMT through inhibition of Snail to increase E-cadherin expression in breast cancer. Here, we evaluated the expression pattern of the components of MTA3 pathway and the corresponding prognostic significance in GEJ adenocarcinoma. MTA3 expression was decreased at both protein and mRNA levels in tumor tissues compared to the non-tumorous and lowed MTA3 levels were noted in tumor cell lines with stronger metastatic potential. Immunohistochemical analysis of a cohort of 128 cases exhibited that patients with lower expression of MTA3 had poorer outcomes. Combined misexpression of MTA3, Snail and E-cadherin had stronger correlation with malignant properties. Collectively, results suggest that the MTA3-regulated EMT pathway is altered to favor EMT and, therefore, disease progression and that MTA3 expression was an independent prognostic factor in patients with GEJ adenocarcinoma.

A novel 3D bone-mimetic scaffold composed of collagen/MTA/MWCNT modulates cell migration and osteogenesis.

PubMed

Valverde, Thalita M; Castro, Elisandra G; Cardoso, Maíssa H S; Martins-Júnior, Paulo A; Souza, Lívia M O; Silva, Patrícia P; Ladeira, Luiz O; Kitten, Gregory T

2016-10-01

This study characterized a three-dimensional (3D) biocomposite scaffolds produced using type I collagen, mineral trioxide aggregate (MTA) and multi-walled carbon nanotubes (MWCNT) to be used in bone tissue regeneration. The scaffolds were analyzed via scanning (SEM) and transmission (TEM) electron microscopy, as well as the viability and migration of osteoblasts and mineralization of the scaffolds. SEM and TEM analyses showed that MTA and MWCNT were distributed as both large agglomerates entrapped within the collagen network and as smaller accumulations or individual molecules dispersed throughout the scaffold. Ultrastructural analysis revealed that osteoblastic MC3T3-E1 cells grown in the biocomposite endocytosed MWCNT, which were localized in the cytoplasm and in vesicles. Analysis of cells grown in the 3D scaffolds demonstrated that >95% of the cells remained viable in all tested combinations and concentrations of the biocomposite. MC3T3-E1 osteoblasts migrated into scaffolds formed with concentrations of type I collagen between 1.75 and 3.0mg/mL. Cells displayed increased migration into scaffolds formed with collagen and a range of low to high concentrations of MTA. In contrast, the presence of MWCNT in the biocomposite had a slight negative effect on migration. Collagen gels containing specific concentrations of MTA, or MWCNT, or combinations of MTA/MWCNT, caused an increase in mineralization of scaffolds. Scaffolds composed of defined concentrations of type I collagen, MTA and MWCNT are biocompatible, promote migration and mineralization of osteoblasts, and hence may be useful as bone tissue mimetics. Copyright © 2016 Elsevier Inc. All rights reserved.

Transcriptome and proteomic analyses reveal multiple differences associated with chloroplast development in the spaceflight-induced wheat albino mutant mta.

PubMed

Shi, Kui; Gu, Jiayu; Guo, Huijun; Zhao, Linshu; Xie, Yongdun; Xiong, Hongchun; Li, Junhui; Zhao, Shirong; Song, Xiyun; Liu, Luxiang

2017-01-01

Chloroplast development is an integral part of plant survival and growth, and occurs in parallel with chlorophyll biosynthesis. However, little is known about the mechanisms underlying chloroplast development in hexaploid wheat. Here, we obtained a spaceflight-induced wheat albino mutant mta. Chloroplast ultra-structural observation showed that chloroplasts of mta exhibit abnormal morphology and distribution compared to wild type. Photosynthetic pigments content was also significantly decreased in mta. Transcriptome and chloroplast proteome profiling of mta and wild type were done to identify differentially expressed genes (DEGs) and proteins (DEPs), respectively. In total 4,588 DEGs including 1,980 up- and 2,608 down-regulated, and 48 chloroplast DEPs including 15 up- and 33 down-regulated were identified in mta. Classification of DEGs revealed that most were involved in chloroplast development, chlorophyll biosynthesis, or photosynthesis. Besides, transcription factors such as PIF3, GLK and MYB which might participate in those pathways were also identified. The correlation analysis between DEGs and DEPs revealed that the transcript-to-protein in abundance was functioned into photosynthesis and chloroplast relevant groups. Real time qPCR analysis validated that the expression level of genes encoding photosynthetic proteins was significantly decreased in mta. Together, our results suggest that the molecular mechanism for albino leaf color formation in mta is a thoroughly regulated and complicated process. The combined analysis of transcriptome and proteome afford comprehensive information for further research on chloroplast development mechanism in wheat. And spaceflight provides a potential means for mutagenesis in crop breeding.

Superintendent Searches: Public or Confidential? Why Confidentiality Contributes to Quality Searches

ERIC Educational Resources Information Center

Attea, William J.

2010-01-01

When a highly qualified candidate learns the search will be conducted confidentially, a positive response is almost certain, in the author's experience running superintendent searches since 1988. Just as likely, the prospective candidate responds negatively to being told the search process will not be confidential. Confidentiality is the item of…

47 CFR 90.663 - MTA-based SMR system operations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... and operate base stations using such frequency. [60 FR 21991, May 4, 1995] ... licensees authorized in the 896-901/935-940 MHz band pursuant to § 90.661 may construct and operate base stations using any frequency identified in their spectrum block anywhere within their authorized MTA...

Effects of LED or laser phototherapy on bone defects grafted with MTA and irradiated with laser or LED light: a comparative Raman spectroscopic study

NASA Astrophysics Data System (ADS)

Pinheiro, Antonio L. B.; Soares, Luiz G. P.; Barbosa, Artur Felipe S.; Silveira, Landulfo, Jr.

2012-03-01

We studied peaks of calcium hydroxyapatite - CHA on defects grafted with MTA, treated or not with Light Emitting Diode - LED or IR Laser. 54 rats were divided in 6 groups each subdivided into 3 subgroups (15,21,30d). LED (λ850 +/- 10nm) or IR Laser (λ850 nm) was applied over (LED) or in 4 points around the defect at 48 h intervals for 15 days. Raman readings were taken at the surface of the defect. The smaller overall intensity of the peak was found in Group MTA + Laser (1510.2 +/- 274.1) and the highest on Group LED (2322 +/- 715). There were no statistically significant differences between non-irradiated subjects on regards the CHA peaks. On the other hand, there were statistically significant differences between the Group Clot and LED, Clot and Laser, and Clot and MTA + Laser (p =0.01, p = 0.02, p = 0.003). There were no significant differences between Group MTA and MTA + LED (p=0.2) but significant differences were seen between Groups MTA and MTA + Laser (p=0.01). Significant differences were also observed between Groups LED and Laser (p <0.001) and between Groups MTA + LED and MTA + Laser (p=0.009). MTA, due to its characteristics, seemed to be directly affected by the light. However, the use of either phototherapy positively affected bone healing similarly as observed on different studies using other biomaterials. The overall analysis of our results indicated that the use of either light source resulted in a better, more advanced, and of quality bone repair.

Evaluation of mineral trioxide aggregate (MTA) versus calcium hydroxide cement (Dycal(®) ) in the formation of a dentine bridge: a randomised controlled trial.

PubMed

Leye Benoist, Fatou; Gaye Ndiaye, Fatou; Kane, Abdoul Wakhabe; Benoist, Henri Michel; Farge, Pierre

2012-02-01

To assess the effectiveness of mineral trioxide aggregate (MTA) used as an indirect pulp-capping material in human molar and premolar teeth. We conducted a clinical evaluation of 60 teeth, which underwent an indirect pulp-capping procedure with either MTA or calcium hydroxide cement (Dycal(®) ). Calcium hydroxide was compared with MTA and the thickness of the newly formed dentine was measured at regular time intervals. The follow-up was at 3 and 6 months, and dentine formation was monitored by radiological measurements on digitised images using Mesurim Pro(®) software. At 3 months, the clinical success rates of MTA and calcium hydroxide were 93% and 73%, respectively (P = 0.02). At 6 months, the success rate was 89.6% with MTA, and remained steady at 73% with calcium hydroxide (P = 0.63). The mean initial residual dentine thickness was 0.23 mm, and increased by 0.121 mm with MTA and by 0.136 mm with calcium hydroxide at 3 months. At 6 months, there was an increase of 0.235 mm with MTA and of 0.221 mm with calcium hydroxide.   A higher success rate was observed in the MTA group relative to the Dycal(®) group after 3 months, which was statistically significant. After 6 months, no statistically significant difference was found in the dentine thickness between the two groups. Additional histological investigations are needed to support these findings. © 2012 FDI World Dental Federation.

28 CFR 115.53 - Inmate access to outside confidential support services.

Code of Federal Regulations, 2014 CFR

2014-07-01

... outside victim advocates for emotional support services related to sexual abuse by giving inmates mailing... confidential emotional support services related to sexual abuse. The agency shall maintain copies of agreements... monitored and the extent to which reports of abuse will be forwarded to authorities in accordance with...

28 CFR 115.53 - Inmate access to outside confidential support services.

Code of Federal Regulations, 2013 CFR

2013-07-01

... outside victim advocates for emotional support services related to sexual abuse by giving inmates mailing... confidential emotional support services related to sexual abuse. The agency shall maintain copies of agreements... monitored and the extent to which reports of abuse will be forwarded to authorities in accordance with...

28 CFR 115.53 - Inmate access to outside confidential support services.

Code of Federal Regulations, 2012 CFR

2012-07-01

... outside victim advocates for emotional support services related to sexual abuse by giving inmates mailing... confidential emotional support services related to sexual abuse. The agency shall maintain copies of agreements... monitored and the extent to which reports of abuse will be forwarded to authorities in accordance with...

Targeting MTA1/HIF-1a signaling by pterostilbene in combination with histone deacetylase inhibitor attenuates prostate cancer progression

USDA-ARS?s Scientific Manuscript database

The metastasis-associated protein 1(MTA1)/ histone deacetylase (HDAC) unit is a cancer progression-related epigenetic regulator, which is overexpressed in hormone-refractory and metastatic prostate cancer. In our previous studies, we found a significantly increased MTA1 expression in a prostate-spec...

Clinical and radiographic evaluation of indirect pulp treatment with MTA and calcium hydroxide in primary teeth (in-vivo study).

PubMed

George, Vimi; Janardhanan, Suresh Kumar; Varma, Balagopal; Kumaran, Parvathy; Xavier, Arun Mamachan

2015-01-01

Clinical and radiographic effects of mineral trioxide aggregate (white MTA) and calcium hydroxide (Dycal) in indirect pulp treatment (IPT) of primary teeth over a period of 6 months. A clinical trial with sample size of 40 primary molars between the age group of 5-9 years, of which, 20 teeth were considered, each for MTA and Dycal. Measurements on the digitized radiographs were performed at baseline, third and sixth month, increase in dentin was then measured using Corel Draw software. Independent t-test had indicated that at the end of 3 months and 6 months, a statistically significant increase in dentin thickness with both MTA and Dycal (P-value ≤ 0.001) was found. Within the MTA group, the thickness of dentin formed was 0.089 mm ± 0.031 mm at first 3 months and 0.055 ± 0.022 mm at the second 3 months, (P ≤ 0.001) evaluated using paired t-test. In the Dycal group, increment in dentin deposited was 0.068 mm at the first 3 months and second 3 months, it was 0.030 mm (P-value ≤ 0.001). Clinically and radiographically, MTA is superior to Dycal as a good IPT medicament in primary teeth.

Applying glass ionomer cement to MTA flow™ and biodentine™ and its effects on the interface layer

NASA Astrophysics Data System (ADS)

Savitri, D.; Suprastiwi, E.; Margono, A.

2017-08-01

This study compared the interface layer formation between Glass Ionomer Cement (GIC) with Biodentine™ and between GIC with MTA Flow™. There were 10 samples in each group. Biodentine™ and MTA Flow™ were filled with GIC in plastic molds then incubated at a temperature of 37 °C with 100% humidity for 24 hours. Samples were sectioned vertically with diamond discs and examined using a scanning electron microscope. The statistical analysis was performed using the Mann-Whitney Test. In group 1, 80% of the samples showed a score of 1 and 20% of the samples showed a score of 2. In group 2, 30% of the samples showed a score of 2 and 70% of the samples showed a score of 3. This clinical trial showed that the formation of interface layers in Biodentine™ and MTA Flow™ were significantly different.

28 CFR 115.253 - Resident access to outside confidential support services.

Code of Federal Regulations, 2014 CFR

2014-07-01

... with access to outside victim advocates for emotional support services related to sexual abuse by... confidential emotional support services related to sexual abuse. The agency shall maintain copies of agreements... communications will be monitored and the extent to which reports of abuse will be forwarded to authorities in...

28 CFR 115.253 - Resident access to outside confidential support services.

Code of Federal Regulations, 2012 CFR

2012-07-01

... with access to outside victim advocates for emotional support services related to sexual abuse by... confidential emotional support services related to sexual abuse. The agency shall maintain copies of agreements... communications will be monitored and the extent to which reports of abuse will be forwarded to authorities in...

28 CFR 115.253 - Resident access to outside confidential support services.

Code of Federal Regulations, 2013 CFR

2013-07-01

... with access to outside victim advocates for emotional support services related to sexual abuse by... confidential emotional support services related to sexual abuse. The agency shall maintain copies of agreements... communications will be monitored and the extent to which reports of abuse will be forwarded to authorities in...

[Repair of a root perforation by using MTA: a case report].

PubMed

Riccitiello, Francesco; Di Caprio, Maria Patrizia; D'Amora, Marilina; Pizza, Nunzia Luisa; Vallone, Gianfranco; D'Ambrosio, Colomba; Amato, Massimo

2013-01-01

Root perforations are accidental events that may occur during the treatment, causing tissue inflammation and alveolar bone loss of integrity of the periodontium. In such cases, the radiological evidence is fundamental in the formulation of the diagnosis, in the choice of therapy (surgical or non-surgical) and finally for the assessment of prognosis of the dental element. In non-surgical treatment of endodontic lesions, the material used for the repair of the defect root should have biocompatibility, antibacterial activity, ability to induce healing of periodontal tissues and radiopacity. The Mineral Trioxide Aggregate (MTA) is a silicate-based cement introduced in dental clinical practice with good radiopacity, biocompatibility and bone induction. This article describes the use of MTA in endodontic repair of a perforation of the middle third root and the success of non-surgical treatment was dimonstrated radiographicaly.

Insight into the architecture of the NuRD complex: structure of the RbAp48-MTA1 subcomplex.

PubMed

Alqarni, Saad S M; Murthy, Andal; Zhang, Wei; Przewloka, Marcin R; Silva, Ana P G; Watson, Aleksandra A; Lejon, Sara; Pei, Xue Y; Smits, Arne H; Kloet, Susan L; Wang, Hongxin; Shepherd, Nicholas E; Stokes, Philippa H; Blobel, Gerd A; Vermeulen, Michiel; Glover, David M; Mackay, Joel P; Laue, Ernest D

2014-08-08

The nucleosome remodeling and deacetylase (NuRD) complex is a widely conserved transcriptional co-regulator that harbors both nucleosome remodeling and histone deacetylase activities. It plays a critical role in the early stages of ES cell differentiation and the reprogramming of somatic to induced pluripotent stem cells. Abnormalities in several NuRD proteins are associated with cancer and aging. We have investigated the architecture of NuRD by determining the structure of a subcomplex comprising RbAp48 and MTA1. Surprisingly, RbAp48 recognizes MTA1 using the same site that it uses to bind histone H4, showing that assembly into NuRD modulates RbAp46/48 interactions with histones. Taken together with other results, our data show that the MTA proteins act as scaffolds for NuRD complex assembly. We further show that the RbAp48-MTA1 interaction is essential for the in vivo integration of RbAp46/48 into the NuRD complex. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Patient Perspectives of Medical Confidentiality

PubMed Central

Sankar, Pamela; Mora, Susan; Merz, Jon F; Jones, Nora L

2003-01-01

OBJECTIVE To lay the groundwork for a better understanding of patient views on medical confidentiality. DESIGN Studies were found by searching medline, bioethicsline, and selected bibliographies. Articles concerning physician perspectives or implications of legal and administrative regulations were excluded. Only peer-reviewed journal articles reporting original research on patients' confidentiality views and conduct were included. MAIN RESULTS Many patients are unaware of or misunderstand their legal or ethical right to medical confidentiality protections, which leads them to both over- and underestimate confidentiality protections. The possibility that medical information might be revealed, intentionally or not, to acquaintances in a clinic or other social community troubles patients as much as information release to insurers or employers. A significant minority of patients distrust confidentiality protections, leading some to report that they delay or forgo medical care. If doubtful that confidentiality will be upheld, patients will act independently to protect information. CONCLUSIONS Our review found a wider variety of understandings and beliefs about medical confidentiality among patients than are often indicated in the writings of practitioners or legal experts. As medical confidentiality regulations evolve, these differences need to be recognized and accounted for in interactions between practitioners and patients. PMID:12911650

Confidentiality in Sports Medicine.

PubMed

Malcolm, Dominic

2016-04-01

This article synthesizes existing literature to provide a summary of the ethical issues concerning patient confidentiality in sport. It outlines the medical principle of confidentiality and identifies cross-cultural ethicolegal variations that shape its implementation. Clinicians' multiple obligations, physical environments, and practice and policy contexts are discussed, and research detailing experiences of maintaining patient confidentiality in sport is reviewed. Policy recommendations for enhancing compliance with this ethical principle are summarized. It is argued that the context of sport exacerbates pressures on clinicians to break patient confidentiality, breaches occur regularly, and interventions are required to enhance ethical compliance in sports medicine. Copyright © 2016 Elsevier Inc. All rights reserved.

"MTA"-an Hydraulic Silicate Cement: review update and setting reaction.

PubMed

Darvell, B W; Wu, R C T

2011-05-01

To review the current status and understanding of Portland cement-like endodontic materials commonly referred to by the trade designation "MTA" (alias "Mineral Trioxide Aggregate"), and to present an outline setting reaction scheme, hitherto unattempted. The literature was searched using on-line tools, overlapping an earlier substantial review to pick up any omissions, including that in respect of ordinary Portland cement (OPC), with which MTA shares much. The search was conducted for the period January 2005 to December 2009 using 'MTA', 'GMTA', 'WMTA', and 'mineral AND trioxide AND aggregate' as keywords, with various on-line search engines including ScienceDirect (http://www.sciencedirect.com), SAGE Journals Online (http://online.sagepub.com), Wiley Online Library (http://onlinelibrary.wiley.com), SciELO Scientific electronic library online (http://www.scielo.br/scielo.php), JSTOR (http://www.jstor.org), and Scopus (http://www.scopus.com). References of articles found were cross-checked where appropriate for missed publications. Manufacturers' and related websites were searched with Google Search (http://www.google.com.hk). A generic name for this class of materials, Hydraulic Silicate Cement (HSC), is proposed, and an outline reaction scheme has been deduced. HSC has distinct advantages apparent, including sealing, sterilizing, mineralizing, dentinogenic and osteogenic capacities, which research continues to demonstrate. However, ad hoc modifications have little supporting justification. While HSC has a definite place in dentistry, with few of the drawbacks associated with other materials, some improvements in handling and other properties are highly desirable, as are studies of the mechanisms of the several beneficial physiological effects. Reference to the extensive, but complex, literature on OPC may provide the necessary insight. Copyright © 2011 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

Methylthioadenosine (MTA) Regulates Liver Cells Proteome and Methylproteome: Implications in Liver Biology and Disease*

PubMed Central

Bigaud, Emilie; Corrales, Fernando J.

2016-01-01

Methylthioadenosine phosphorylase (MTAP), a key enzyme in the adenine and methionine salvage pathways, catalyzes the hydrolysis of methylthioadenosine (MTA), a compound suggested to affect pivotal cellular processes in part through the regulation of protein methylation. MTAP is expressed in a wide range of cell types and tissues, and its deletion is common to cancer cells and in liver injury. The aim of this study was to investigate the proteome and methyl proteome alterations triggered by MTAP deficiency in liver cells to define novel regulatory mechanisms that may explain the pathogenic processes of liver diseases. iTRAQ analysis resulted in the identification of 216 differential proteins (p < 0.05) that suggest deregulation of cellular pathways as those mediated by ERK or NFκB. R-methyl proteome analysis led to the identification of 74 differentially methylated proteins between SK-Hep1 and SK-Hep1+ cells, including 116 new methylation sites. Restoring normal MTA levels in SK-Hep1+ cells parallels the specific methylation of 56 proteins, including KRT8, TGF, and CTF8A, which provides a novel regulatory mechanism of their activity with potential implications in carcinogenesis. Inhibition of RNA-binding proteins methylation is especially relevant upon accumulation of MTA. As an example, methylation of quaking protein in Arg242 and Arg256 in SK-Hep1+ cells may play a pivotal role in the regulation of its activity as indicated by the up-regulation of its target protein p27kip1. The phenotype associated with a MTAP deficiency was further verified in the liver of MTAP± mice. Our data support that MTAP deficiency leads to MTA accumulation and deregulation of central cellular pathways, increasing proliferation and decreasing the susceptibility to chemotherapeutic drugs, which involves differential protein methylation. Data are available via ProteomeXchange with identifier PXD002957 (http://www.ebi.ac.uk/pride/archive/projects/PXD002957). PMID:26819315

Influence of phototherapies on the outcome of complete tibial fractures grafted or not with MTA: Raman spectroscopic study on rabbits

NASA Astrophysics Data System (ADS)

Pinheiro, Antônio L. B.; Soares, Luiz G. P.; da Silva, Aline C. P.; Santos, Nicole R. S.; da Silva, Anna Paula L. T.; Neves, Bruno Luiz R. C.; Soares, Amanda P.; Silveira, Landulfo

2018-02-01

The aim of the present study was to assess, by means of Raman spectroscopy, the repair of complete surgical tibial fractures fixed with wire osteosynthesis or miniplates treated or not with infrared laser (λ780 nm) or infrared LED (λ850 +/- 10 nm) lights, 142.8 J/cm2 per treatment, associated or not to the use of mineral trioxide aggregate (MTA) cement. Surgical fractures were created on 36 rabbits and fixed with WO or miniplates and some groups were grafted with MTA. Irradiated groups received lights at every other day for 15 days and sacrifice occurred after 30 days. The results showed that only irradiation with either laser or LED influenced the peaks of phosphate ( 960 cm-1) and carbonated ( 1,070 cm-1) hydroxyapatite. Collagen peak (1,450 cm-1) was influenced by both the use of MTA and irradiation with either laser or LED. It is concluded that the use of either laser or LED phototherapy associated to MTA cement was efficacious on improving the repair of complete tibial fractures treated with wire osteosynthesis or miniplates.

MTA apical plugs in the treatment of traumatized immature teeth with large periapical lesions.

PubMed

Cehreli, Zafer C; Sara, Sezgi; Uysal, Serdar; Turgut, Melek D

2011-02-01

This case report describes the management of a late-referral case of periapically involved, traumatized immature permanent incisors by endodontic treatment and the use of mineral trioxide aggregate (MTA) apical plugs. A 10-year-old boy was referred to the clinic with a chief complaint of pain in his maxillary central incisors, which had experienced subluxation trauma 2 years earlier. Periapical radiograph of the teeth showed incomplete root development with wide-open apices and large periradicular lesions. The canals were gently debrided using K-files in conjunction with 2.5% NaOCl irrigation and 2% chlorhexidine for final flush. The root canals became asymptomatic after employing the same endodontic regimen for three visits. MTA plugs were placed in the apical area of the root canals, and the rest of the canal space was obturated by warm compaction of gutta-percha and AH Plus sealer. Resolution of the large periapical lesions was observed 2 months after treatment. At 18 months, the periapical areas revealed radiographic evidence of bone healing. Following successful removal of the toxic content of the root canal, placement of MTA plugs resulted in both healing of the periradicular radiolucency and regeneration of the periapical tissue. © 2010 John Wiley & Sons A/S.

Breaching confidentiality to protect the public: evolving standards of medical confidentiality for military detainees.

PubMed

Wynia, Matthew K

2007-08-01

Confidentiality is a core value in medicine and public health yet, like other core values, it is not absolute. Medical ethics has typically allowed for breaches of confidentiality when there is a credible threat of significant harm to an identifiable third party. Medical ethics has been less explicit in spelling out criteria for allowing breaches of confidentiality to protect populations, instead tending to defer these decisions to the law. But recently, issues in military detention settings have raised the profile of decisions to breach medical confidentiality in efforts to protect the broader population. National and international ethics documents say little about the confidentiality of detainee medical records. But initial decisions to use detainee medical records to help craft coercive interrogations led to widespread condemnation, and might have contributed to detainee health problems, such as a large number of suicide attempts several of which have been successful. More recent military guidance seems to reflect lessons learned from these problems and does more to protect detainee records. For the public health system, this experience is a reminder of the importance of confidentiality in creating trustworthy, and effective, means to protect the public's health.

Improving amphetamine therapeutic selectivity: N,N-dimethyl-MTA has dopaminergic effects and does not produce aortic contraction.

PubMed

Sotomayor-Zárate, Ramón; Jara, Pablo; Araos, Patricio; Vinet, Raúl; Quiroz, Gabriel; Renard, Georgina M; Espinosa, Pedro; Hurtado-Guzmán, Claudio; Moya, Pablo R; Iturriaga-Vásquez, Patricio; Gysling, Katia; Reyes-Parada, Miguel

2014-05-01

Amphetamine derivatives have therapeutic potential in diseases such as attention deficit hyperactivity disorder, narcolepsy and obesity. However, their prolonged use has been associated with cardiovascular toxicity and addiction. In recent years, we have studied the pharmacological effects of amphetamine derivatives such as methylthioamphetamine (MTA) and N,N-dimethyl-thioamphetamine, with the aim of improving their therapeutic selectivity. In this work, we show that similarly to MTA, N,N-dimethyl-thioamphetamine has effects on the dopamine system, producing a significant increase in extracellular levels of dopamine (as measured by in vivo brain microdialysis) and locomotor activity, which is a behavioural measure of dopaminergic activation. However, unlike MTA, N,N-dimethyl- thioamphetamine does not produce aortic contraction in vitro. Our results show that N,N-dimethyl-thioamphetamine is a drug that retains the dopaminergic effects of amphetamine derivatives but exhibits a lower potential for producing cardiovascular side effects. © 2013 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).

AIDS and medical confidentiality.

PubMed

Gillon, R

1987-06-27

In summary, I have argued that the arguments offered or hinted at in favour of doctors' breaking medical confidentiality by passing on information about their patients' HIV state to others, including other doctors, when this is against the patient's considered wishes are generally unconvincing. Although in highly exceptional cases there may be justifications for overriding confidentiality, the requirement of medical confidentiality is a very strong, though not absolute, obligation. Patients, their contacts, doctors and their staff, and the common good are most likely to be best served if that tradition continues to be honoured.

Overexpression of MTA1 and loss of KAI-1 and KiSS-1 expressions are associated with invasion, metastasis, and poor-prognosis of gallbladder adenocarcinoma.

PubMed

Wang, Wenjun; Yang, Zhu-lin; Liu, Jie-qiong; Yang, Le-ping; Yang, Xiao-jing; Fu, Xi

2014-01-01

Over 90% of patients with gallbladder cancer have invasion and/or metastasis when they are diagnosed at the clinic. Such patients usually have an extremely poor prognosis. The molecular mechanism responsible for the high prevalence of invasion and metastasis remains unknown. We investigated the expression of two metastasis-suppression genes--KAI-1 and KiSS-1--and a metastasis-associated gene--MTA1--in 108 adenocarcinomas, 15 gallbladder polyps, 35 chronic cholecystitis tissues, and 46 peritumoral tissues using in situ hybridization or immunohistochemistry. We demonstrated that positive MTA1 expression was significantly higher whereas positive expressions of KAI-1 and KiSS-1 genes were significantly lower in gallbladder adenocarcinoma than in peritumoral tissues, polyps, and chronic cholecystitis. Positive MTA1 expression was significantly lower, but positive KAI-1 and KiSS-1 expressions were significantly higher in cases with well-differentiated adenocarcinoma, smaller tumor mass, no metastasis of lymph node, and no invasion of regional tissues than in cases having poorly differentiated adenocarcinoma, larger tumor mass, metastasis and invasion. Univariate Kaplan-Meier analysis showed that increased expression of MTA1 and lowered expression of KAI-1 and KiSS-1 were significantly associated with decreased overall survival. Cox regression analysis showed that tumor mass, lymph node metastasis, invasion, and MTA1 expression levels negatively correlated with survival. Our study suggested that KAI-1, KiSS-1, and MTA1 might be important biological markers involved in the carcinogenesis, metastasis, and invasion of gallbladder adenocarcinoma, but MTA1 is an independent factor of prognosis.

Evaluation of the tissue reaction to fast endodontic cement (CER) and Angelus MTA.

PubMed

Gomes-Filho, João Eduardo; Rodrigues, Guilherme; Watanabe, Simone; Estrada Bernabé, Pedro Felício; Lodi, Carolina Simonett; Gomes, Alessandra Cristina; Faria, Max Doulgas; Domingos Dos Santos, Alailson; Silos Moraes, João Carlos

2009-10-01

A new cement (CER; Cimento Endodôntico Rápido or fast endodontic cement) has been developed to improve handling properties. It is a formulation that has Portland cement in gel. However, there had not yet been any study evaluating its biologic properties. The purpose of this study was to evaluate the rat subcutaneous tissue response to CER and Angelus MTA. The materials were placed in polyethylene tubes and implanted into dorsal connective tissue of Wistar rats for 7, 30, and 60 days. The specimens were prepared to be stained with hematoxylin-eosin or von Kossa or not stained for polarized light. The presence of inflammation, predominant cell type, calcification, and thickness of fibrous connective tissue were recorded. Scores were defined as follows: 0, none or few inflammatory cells, no reaction; 1, <25 cells, mild reaction; 2, 25-125 cells, moderate reaction; 3, >125 cells, severe reaction. Fibrous capsule was categorized as thin when thickness was <150 mum and thick at >150 mum. Necrosis and formation of calcification were both recorded. Both materials Angelus MTA and CER caused moderate reactions at 7 days, which decreased with time. The response was similar to the control at 30 and 60 days with Angelus MTA and CER, characterized by organized connective tissue and presence of some chronic inflammatory cells. Mineralization and granulations birefringent to polarized light were observed with both materials. It was possible to conclude that CER was biocompatible and stimulated mineralization.

29 CFR 90.33 - Confidential business information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 1 2014-07-01 2013-07-01 true Confidential business information. 90.33 Section 90.33 Labor... General Provisions § 90.33 Confidential business information. (a) Definition. Confidential business... of information submitted in confidence. Business information which is to be treated as confidential...

Confidentiality with Minors: Mental Health Counselors' Attitudes toward Breaching or Preserving Confidentiality.

ERIC Educational Resources Information Center

Isaacs, Madelyn L.; Stone, Carolyn

2001-01-01

Describes the results of research that explored how mental health counselors consider the confidentiality of minors and conditions under which they would breach it. Results indicate that mental health counselors are protective of their minor clients' confidentiality rights with variation based on degree of seriousness and age of the client.…

37 CFR 382.5 - Confidential information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Confidential information. 382... SATELLITE DIGITAL AUDIO RADIO SERVICES Preexisting Subscription Services § 382.5 Confidential information. (a) For purposes of this subpart, confidential information shall include statements of account and...

37 CFR 380.5 - Confidential Information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Confidential Information. 380... Noncommercial Webcasters § 380.5 Confidential Information. (a) Definition. For purposes of this subpart, “Confidential Information” shall include the statements of account and any information contained therein...

37 CFR 262.5 - Confidential information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Confidential information. 262... Confidential information. (a) Definition. For purposes of this part, “Confidential Information” shall include the statements of account, any information contained therein, including the amount of royalty payments...

37 CFR 384.5 - Confidential information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Confidential information. 384... BUSINESS ESTABLISHMENT SERVICES § 384.5 Confidential information. (a) Definition. For purposes of this section, “Confidential Information” shall include the statements of account and any information contained...

37 CFR 380.14 - Confidential Information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Confidential Information. 380... Confidential Information. (a) Definition. For purposes of this subpart, “Confidential Information” shall include the statements of account and any information contained therein, including the amount of royalty...

37 CFR 261.5 - Confidential information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Confidential information. 261... TRANSMISSIONS AND THE MAKING OF EPHEMERAL REPRODUCTIONS § 261.5 Confidential information. (a) For purposes of this part, “Confidential Information” shall include the statements of account, any information...

37 CFR 380.24 - Confidential Information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Confidential Information. 380... Webcasters § 380.24 Confidential Information. (a) Definition. For purposes of this subpart, “Confidential Information” shall include the statements of account and any information contained therein, including the...

37 CFR 382.14 - Confidential information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Confidential information. 382... Confidential information. (a) Definition. For purposes of this subpart, “Confidential Information” shall include the statements of account and any information contained therein, including the amount of royalty...

37 CFR 382.14 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Confidential information. 382... Confidential information. (a) Definition. For purposes of this subpart, “Confidential Information” shall include the statements of account and any information contained therein, including the amount of royalty...

37 CFR 384.5 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Confidential information. 384... BUSINESS ESTABLISHMENT SERVICES § 384.5 Confidential information. (a) Definition. For purposes of this part, “Confidential Information” shall include the statements of account, any information contained therein, including...

42 CFR 2.63 - Confidential communications.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Confidential communications. 2.63 Section 2.63 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS... Confidential communications. (a) A court order under these regulations may authorize disclosure of confidential...

15 CFR 705.6 - Confidential information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Confidential information. 705.6... EFFECT OF IMPORTED ARTICLES ON THE NATIONAL SECURITY § 705.6 Confidential information. (a) Any... confidential information (trade secrets, commercial or financial information, or any other information...

15 CFR 705.6 - Confidential information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Confidential information. 705.6... EFFECT OF IMPORTED ARTICLES ON THE NATIONAL SECURITY § 705.6 Confidential information. (a) Any... confidential information (trade secrets, commercial or financial information, or any other information...

15 CFR 705.6 - Confidential information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Confidential information. 705.6... EFFECT OF IMPORTED ARTICLES ON THE NATIONAL SECURITY § 705.6 Confidential information. (a) Any... confidential information (trade secrets, commercial or financial information, or any other information...

15 CFR 705.6 - Confidential information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Confidential information. 705.6... EFFECT OF IMPORTED ARTICLES ON THE NATIONAL SECURITY § 705.6 Confidential information. (a) Any... confidential information (trade secrets, commercial or financial information, or any other information...

MTA-enriched nanocomposite TiO(2)-polymeric powder coatings support human mesenchymal cell attachment and growth.

PubMed

Shi, Wen; Mozumder, Mohammad Sayem; Zhang, Hui; Zhu, Jesse; Perinpanayagam, Hiran

2012-10-01

The objective of the study described in this paper was the development of novel polymer/ceramic nanocomposite coatings for implants through the application of ultrafine powder coating technology. Polyester resins were combined with µm-sized TiO(2) (25%) as the biocompatibility agent, nTiO(2) (0.5%) as the flow additive and mineral trioxide aggregates (ProRoot® MTA, 5%) as bioactive ceramics. Ultrafine powders were prepared and applied to titanium to create continuous polymeric powder coatings (PPCs) through the application of electrostatic ultrafine powder coating technology. Energy dispersive x-ray analysis confirmed that MTA had been incorporated into the PPCs, and elemental mapping showed that it had formed small clusters that were evenly distributed across the surface. Scanning electron microscopy (SEM) revealed continuous and smooth, but highly textured surface coatings that contrasted with the scalloped appearance of commercially pure titanium (cpTi) controls. Atomic force microscopy revealed intricate nano-topographies with an abundance of submicron-sized pits and nano-projections, evenly dispersed across their surfaces. Inverted fluorescence microscopy, SEM and cell counts showed that human embryonic palatal mesenchymal cells attached and spread out onto PPC and MTA-enriched PPCs within 24 h. Mitochondrial enzyme activity measured viable and metabolically active cells on all of the surfaces. After 72 h of growth, cell counts and metabolic activity were significantly higher (P < 0.05) on the grey-MTA enriched PPC surfaces, than on unmodified PPC and cpTi. The novel polymer/ceramic nanocomposites that were created with ultrafine powder coating technology were continuous, homogenous and nano-rough coatings that enhanced human mesenchymal cell attachment and growth.

37 CFR 261.5 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Confidential information. 261... THE MAKING OF EPHEMERAL REPRODUCTIONS § 261.5 Confidential information. (a) For purposes of this part, “Confidential Information” shall include the statements of account, any information contained therein, including...

13 CFR 120.1060 - Confidentiality of Reports, Risk Ratings and related Confidential Information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Confidentiality of Reports, Risk Ratings and related Confidential Information. 120.1060 Section 120.1060 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Risk-Based Lender Oversight Supervision § 120.1060...

7 CFR 983.65 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 983.65 Section 983.65..., ARIZONA, AND NEW MEXICO Reports, Books and Records § 983.65 Confidential information. All reports and records furnished or submitted by handlers to the committee which include confidential data or information...

School Counselors and Confidentiality: Factors Affecting Professional Choices.

ERIC Educational Resources Information Center

Isaacs, Madelyn L; Stone, Carolyn

1999-01-01

Counselors who work with children regularly face the ethical dilemma of confidentiality for which there are few definitive answers. Confidentiality and Minors Questionnaire about managing student's confidential information was distributed to district guidance supervisors. It appears that counselors' judgment of what breaches confidentiality is…

Dental Stem Cell Migration on Pulp Ceiling Cavities Filled with MTA, Dentin Chips, or Bio-Oss

PubMed Central

Lymperi, Stefania; Taraslia, Vasiliki; Tsatsoulis, Ioannis N.; Samara, Athina; Agrafioti, Anastasia; Anastasiadou, Ema; Kontakiotis, Evangelos

2015-01-01

MTA, Bio-Oss, and dentin chips have been successfully used in endodontics. The aim of this study was to assess the adhesion and migration of dental stem cells on human pulp ceiling cavities filled with these endodontic materials in an experimental model, which mimics the clinical conditions of regenerative endodontics. Cavities were formed, by a homemade mold, on untouched third molars, filled with endodontic materials, and observed with electron microscopy. Cells were seeded on cavities' surface and their morphology and number were analysed. The phenomenon of tropism was assessed in a migration assay. All three materials demonstrated appropriate microstructures for cell attachment. Cells grew on all reagents, but they showed a differential morphology. Moreover, variations were observed when comparing cells numbers on cavity's filling versus the surrounding dentine disc. The highest number of cells was recorded on dentin chips whereas the opposite was true for Bio-Oss. This was confirmed in the migration assay where a statistically significant lower number of cells migrated towards Bio-Oss as compared to MTA and dentin chips. This study highlights that MTA and dentin chips have a greater potential compared to Bio-Oss regarding the attraction of dental stem cells and are good candidates for bioengineered pulp regeneration. PMID:26146613

Data Confidentiality Challenges in Big Data Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yin, Jian; Zhao, Dongfang

In this paper, we address the problem of data confidentiality in big data analytics. In many fields, much useful patterns can be extracted by applying machine learning techniques to big data. However, data confidentiality must be protected. In many scenarios, data confidentiality could well be a prerequisite for data to be shared. We present a scheme to provide provable secure data confidentiality and discuss various techniques to optimize performance of such a system.

A challenge to unqualified medical confidentiality.

PubMed

Bozzo, Alexander

2018-04-01

Medical personnel sometimes face a seeming conflict between a duty to respect patient confidentiality and a duty to warn or protect endangered third parties. The conventional answer to dilemmas of this sort is that, in certain circumstances, medical professionals have an obligation to breach confidentiality. Kenneth Kipnis has argued, however, that the conventional wisdom on the nature of medical confidentiality is mistaken. Kipnis argues that the obligation to respect patient confidentiality is unqualified or absolute, since unqualified policies can save more lives in the long run. In this paper, I identify the form of Kipnis's argument and present a challenge to it. I conclude that, as matters stand now, a qualified confidentiality policy is the more rational choice. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

40 CFR 85.1712 - Treatment of confidential information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Treatment of confidential information... and Motor Vehicle Engines § 85.1712 Treatment of confidential information. (a) Any person or... confidential treatment as provided by 40 CFR part 2, subpart B. (b) Any claim of confidentiality must accompany...

21 CFR 26.76 - Confidentiality.

Code of Federal Regulations, 2013 CFR

2013-04-01

... public, information exchanged under this part that constitutes trade secrets, confidential commercial or... OF PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT REPORTS... under its laws, the confidentiality of information exchanged under this part. (b) In particular, neither...

46 CFR 221.79 - Request for confidential treatment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Request for confidential treatment. 221.79 Section 221... INTERESTS Civil Penalties § 221.79 Request for confidential treatment. (a) In addition to information treated as confidential under § 221.77 of this subpart, a request for confidential treatment of a document...

Confidential donation confirmation as an alternative to confidential unit exclusion: 15 months experience of the HEMOMINAS foundation.

PubMed

Loureiro, Flávia Cristine Martineli; Oliveira, Cláudia Di Lorenzo; Proietti, Anna Bárbara F Carneiro; Proietti, Fernando Augusto

2011-01-01

Confidential unit exclusion remains a controversial strategy to reduce the residual risk of transfusion-transmitted infections. This study aimed to analyze confidential unit exclusion from its development in a large institution in light of confidential donation confirmation. Data of individuals who donated from October 1, 2008 to December 31, 2009 were analyzed in a case-control study. The serological results and sociodemographic characteristics of donors who did not confirm their donations were compared to those who did. Variables with p-values < 0.20 in univariate analysis were included in a logistic multivariate analysis. In the univariate analysis there was a statically significant association between positive serological results and response to confidential donation confirmation of "No". Donation type, (firsttime or return donor - OR 1.69, CI 1.37-2.09), gender (OR 1.66, CI 1.35-2.04), education level (OR 2.82, CI 2.30-3.47) and ethnic background (OR 0.67, CI 0.55-0.82) were included in the final logistic regression model. In all logistic regression models analyzed, the serological suitability and confidential donation confirmation were not found to be statistically associated. The adoption of new measures of clinical classification such as audiovisual touch-screen computer-assisted self-administered interviews might be more effective than confidential unit exclusion in the identification of donor risk behavior. The requirement that transfusion services continue to use confidential unit exclusion needs to be debated in countries where more specific and sensitive clinical and serological screening methods are available. Our findings suggest that there are not enough benefits to justify continued use of confidential donation confirmation in the analyzed institution.

Confidential donation confirmation as an alternative to confidential unit exclusion: 15 months experience of the HEMOMINAS foundation

PubMed Central

Loureiro, Flávia Cristine Martineli; Oliveira, Cláudia Di Lorenzo; Proietti, Anna Bárbara F. Carneiro; Proietti, Fernando Augusto

2011-01-01

Background Confidential unit exclusion remains a controversial strategy to reduce the residual risk of transfusion-transmitted infections. Objective This study aimed to analyze confidential unit exclusion from its development in a large institution in light of confidential donation confirmation. Methods Data of individuals who donated from October 1, 2008 to December 31, 2009 were analyzed in a case-control study. The serological results and sociodemographic characteristics of donors who did not confirm their donations were compared to those who did. Variables with p-values < 0.20 in univariate analysis were included in a logistic multivariate analysis. Results In the univariate analysis there was a statically significant association between positive serological results and response to confidential donation confirmation of "No". Donation type, (firsttime or return donor - OR 1.69, CI 1.37-2.09), gender (OR 1.66, CI 1.35-2.04), education level (OR 2.82, CI 2.30-3.47) and ethnic background (OR 0.67, CI 0.55-0.82) were included in the final logistic regression model. In all logistic regression models analyzed, the serological suitability and confidential donation confirmation were not found to be statistically associated. The adoption of new measures of clinical classification such as audiovisual touch-screen computer-assisted self-administered interviews might be more effective than confidential unit exclusion in the identification of donor risk behavior. The requirement that transfusion services continue to use confidential unit exclusion needs to be debated in countries where more specific and sensitive clinical and serological screening methods are available. Conclusion Our findings suggest that there are not enough benefits to justify continued use of confidential donation confirmation in the analyzed institution. PMID:23049316

29 CFR 1691.3 - Confidentiality.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 4 2013-07-01 2013-07-01 false Confidentiality. 1691.3 Section 1691.3 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES FOR COMPLAINTS OF EMPLOYMENT DISCRIMINATION FILED AGAINST RECIPIENTS OF FEDERAL FINANCIAL ASSISTANCE § 1691.3 Confidentiality...

14 CFR 413.9 - Confidentiality.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Confidentiality. 413.9 Section 413.9 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LICENSE APPLICATION PROCEDURES § 413.9 Confidentiality. (a) Any person furnishing...

14 CFR 413.9 - Confidentiality.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Confidentiality. 413.9 Section 413.9 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LICENSE APPLICATION PROCEDURES § 413.9 Confidentiality. (a) Any person furnishing...

14 CFR 414.13 - Confidentiality.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Confidentiality. 414.13 Section 414.13 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING SAFETY APPROVALS Application Procedures § 414.13 Confidentiality. (a) To ensure...

19 CFR 210.5 - Confidential business information.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 3 2011-04-01 2011-04-01 false Confidential business information. 210.5 Section... business information. (a) Definition and submission. Confidential business information shall be defined and... law judge, or another section of this part states otherwise, confidential business information shall...

19 CFR 210.5 - Confidential business information.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 3 2013-04-01 2013-04-01 false Confidential business information. 210.5 Section... business information. (a) Definition and submission. Confidential business information shall be defined and... law judge, or another section of this part states otherwise, confidential business information shall...

5 CFR 294.112 - Confidential commercial information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Confidential commercial information. 294... § 294.112 Confidential commercial information. (a) In general, OPM will not disclose confidential commercial information in response to a Freedom of Information Act request except in accordance with this...

21 CFR 807.95 - Confidentiality of information.

Code of Federal Regulations, 2014 CFR

2014-04-01

... and Drug Administration hold as confidential commercial information the intent to market the device... market the device to be confidential commercial information; (ii) That neither the person nor, to the... device is confidential commercial information. (c) Where the Commissioner determines that the person has...

21 CFR 807.95 - Confidentiality of information.

Code of Federal Regulations, 2012 CFR

2012-04-01

... and Drug Administration hold as confidential commercial information the intent to market the device... market the device to be confidential commercial information; (ii) That neither the person nor, to the... device is confidential commercial information. (c) Where the Commissioner determines that the person has...

21 CFR 807.95 - Confidentiality of information.

Code of Federal Regulations, 2013 CFR

2013-04-01

... and Drug Administration hold as confidential commercial information the intent to market the device... market the device to be confidential commercial information; (ii) That neither the person nor, to the... device is confidential commercial information. (c) Where the Commissioner determines that the person has...

21 CFR 807.95 - Confidentiality of information.

Code of Federal Regulations, 2011 CFR

2011-04-01

... and Drug Administration hold as confidential commercial information the intent to market the device... market the device to be confidential commercial information; (ii) That neither the person nor, to the... device is confidential commercial information. (c) Where the Commissioner determines that the person has...

21 CFR 720.8 - Confidentiality of statements.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) COSMETICS VOLUNTARY FILING OF COSMETIC PRODUCT INGREDIENT COMPOSITION STATEMENTS § 720.8 Confidentiality of... request for confidentiality of a cosmetic ingredient submitted with such forms or separately will be... chapter. (b) Any request for confidentiality of the identity of a cosmetic ingredient should contain a...

21 CFR 720.8 - Confidentiality of statements.

Code of Federal Regulations, 2012 CFR

2012-04-01

...) COSMETICS VOLUNTARY FILING OF COSMETIC PRODUCT INGREDIENT COMPOSITION STATEMENTS § 720.8 Confidentiality of... request for confidentiality of a cosmetic ingredient submitted with such forms or separately will be... chapter. (b) Any request for confidentiality of the identity of a cosmetic ingredient should contain a...

21 CFR 720.8 - Confidentiality of statements.

Code of Federal Regulations, 2011 CFR

2011-04-01

...) COSMETICS VOLUNTARY FILING OF COSMETIC PRODUCT INGREDIENT COMPOSITION STATEMENTS § 720.8 Confidentiality of... request for confidentiality of a cosmetic ingredient submitted with such forms or separately will be... chapter. (b) Any request for confidentiality of the identity of a cosmetic ingredient should contain a...

21 CFR 720.8 - Confidentiality of statements.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) COSMETICS VOLUNTARY FILING OF COSMETIC PRODUCT INGREDIENT COMPOSITION STATEMENTS § 720.8 Confidentiality of... request for confidentiality of a cosmetic ingredient submitted with such forms or separately will be... chapter. (b) Any request for confidentiality of the identity of a cosmetic ingredient should contain a...

21 CFR 720.8 - Confidentiality of statements.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) COSMETICS VOLUNTARY FILING OF COSMETIC PRODUCT INGREDIENT COMPOSITION STATEMENTS § 720.8 Confidentiality of... request for confidentiality of a cosmetic ingredient submitted with such forms or separately will be... chapter. (b) Any request for confidentiality of the identity of a cosmetic ingredient should contain a...

Evaluation of pH and calcium ion diffusion from calcium hydroxide pastes and MTA.

PubMed

Sáez, María Del M; López, Gabriela L; Atlas, Diana; de la Casa, María L

2017-04-01

The aim of this ex vivo study was to evaluate changes in pH and calcium ion diffusion through root dentin from calcium hydroxide (Ca (OH) 2 ) and mineral trioxide aggregate (MTA) pastes at 7, 30 and 60 days; and the relationship between pH and ion diffusion. Thirty-two human premolars were used. Crowns were sectioned and root canals instrumented and filled in with the following preparations: 1) Ca(OH) 2 + distilled water (n=7); 2) Ca(OH) 2 + 0.1% chlorhexidine gluconate (n=7); 3) MTA + distilled water (n=7); 4) MTA + 0.1% chlorhexidine gluconate (CHX) (n=7); 5) distilled water (n=2) (control); 6) 0.1% chlorhexidine gluconate (n=2) (control). The apex and coronary opening were sealed with IRM. Roots were placed in Eppendorf tubes with 1 ml distilled water at 37°C and 100% humidity. At baseline, 7, 30 and 60 days, pH was measured with pH meter, and calcium ion content in the solution was analyzed by atomic absorption spectrophotometry. The data were statistically analyzed using ANOVA, simple linear regression analysis and Pearson's correlation test. The highest pH values were achieved with calcium hydroxide pastes at 60 days (p ≤ 0.05). Calcium ions were released in all groups. The calcium hydroxide paste with distilled water at 60 days had the highest calcium ion value (p ≤ 0.01). There was a positive correlation between calcium and pH values. Sociedad Argentina de Investigación Odontológica.

22 CFR 130.15 - Confidential business information.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Confidential business information. 130.15... CONTRIBUTIONS, FEES AND COMMISSIONS § 130.15 Confidential business information. (a) Any person who is required... person considers to be confidential business information. No person, including any applicant or supplier...

22 CFR 130.15 - Confidential business information.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., confidential business information means commercial or financial information which by law is entitled to... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Confidential business information. 130.15... CONTRIBUTIONS, FEES AND COMMISSIONS § 130.15 Confidential business information. (a) Any person who is required...

22 CFR 1304.7 - Confidential commercial information.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Confidential commercial information. 1304.7... § 1304.7 Confidential commercial information. (a) Notice to submitters. The FOIA Officer shall, to the extent permitted by law, provide a submitter who provides confidential commercial information to the FOIA...

7 CFR 1280.634 - Confidentiality.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 10 2014-01-01 2014-01-01 false Confidentiality. 1280.634 Section 1280.634 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... persons voting in the referendum and ballots shall be confidential and the contents of the ballots shall...

7 CFR 1280.634 - Confidentiality.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 10 2011-01-01 2011-01-01 false Confidentiality. 1280.634 Section 1280.634 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... persons voting in the referendum and ballots shall be confidential and the contents of the ballots shall...

7 CFR 1280.634 - Confidentiality.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 10 2013-01-01 2013-01-01 false Confidentiality. 1280.634 Section 1280.634 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... persons voting in the referendum and ballots shall be confidential and the contents of the ballots shall...

7 CFR 1280.634 - Confidentiality.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 10 2012-01-01 2012-01-01 false Confidentiality. 1280.634 Section 1280.634 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... persons voting in the referendum and ballots shall be confidential and the contents of the ballots shall...

40 CFR 710.38 - Confidentiality.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting § 710.38 Confidentiality. (a) Any person... if the identity of that substance is treated as confidential in the Master Inventory File as of the...

40 CFR 403.14 - Confidentiality.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 30 2013-07-01 2012-07-01 true Confidentiality. 403.14 Section 403.14 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GENERAL PRETREATMENT REGULATIONS FOR EXISTING AND NEW SOURCES OF POLLUTION § 403.14 Confidentiality. (a...

7 CFR 1280.634 - Confidentiality.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidentiality. 1280.634 Section 1280.634 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... persons voting in the referendum and ballots shall be confidential and the contents of the ballots shall...

19 CFR 143.4 - Confidentiality of data.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Confidentiality of data. 143.4 Section 143.4... TREASURY (CONTINUED) SPECIAL ENTRY PROCEDURES Automated Broker Interface § 143.4 Confidentiality of data. The electronic data received and exchanged by a service bureau shall be considered confidential, and...

[Confidentiality as ethical responsibility and legal duty].

PubMed

Arroyo Cordero, Tamara

2009-01-01

The article analyzes the challenge that the health professionals encounter when trying to protect their patient's confidentiality, considering the increasing demand for globalization of the information. It discusses the importance that confidentiality has for the therapeutic alliance and how the government has protected it throughout time. It identifies weak areas in the protection of confidentiality, especially in the psychiatry field. Finally, it invites the reader to consider the real benefits of sharing patient's information when deciding whether to brake or not the patient's confidentiality.

Confidentiality: a survey in a research hospital.

PubMed

Grady, C; Jacob, J; Romano, C

1991-01-01

Despite the many justifications for protecting patient confidentiality, we recognize that confidentiality cannot be absolute. Our world of automated information and easy access and storage poses many threats to confidentiality. This paper has described a survey conducted at the NIH Clinical Center to assess the knowledge, attitudes, and behaviors of clinical physicians and nurses about confidentiality of patient information. The survey findings demonstrate the need for reminders and increased awareness about confidentiality in our setting. Most of the survey respondents had a good knowledge of what was expected of them, and they believed that confidentiality was important and maintaining it was their responsibility. Of interest was that in several simulated clinical situations, there was a discrepancy between what respondents indicated they should do and what they thought they would do. The biggest discrepancies appeared in situations that involved overhearing a patient conversation on the elevator, approaching an unfamiliar person who is reading a medical record in the nurses' station, and answering a patient's inquiry about the status of another patient. The findings support the speculation that this difference may be attributed to discomfort or decreased awareness, and not necessarily to lack of knowledge. Results indicate that policies and administrative expectations should be frequently communicated and enforced, and that educational programs that address issues of confidentiality should be provided. The results of this survey have been influential in guiding educational strategies and administrative activities at the clinical center. The clinical center initiated a confidentiality awareness campaign, displaying a new poster every three months in strategic locations and distributing other tangible reminders (such as pens, magnets, and buttons) containing the same confidentiality message.(ABSTRACT TRUNCATED AT 250 WORDS)

15 CFR 806.5 - Confidentiality.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Confidentiality. 806.5 Section 806.5 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF ECONOMIC ANALYSIS, DEPARTMENT OF COMMERCE DIRECT INVESTMENT SURVEYS § 806.5 Confidentiality. Information...

10 CFR 431.407 - Confidentiality.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Confidentiality. 431.407 Section 431.407 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT General Provisions § 431.407 Confidentiality. Pursuant to the provisions of 10 CFR 1004.11, any...

31 CFR 129.5 - Confidentiality.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Confidentiality. 129.5 Section 129.5 Money and Finance: Treasury Regulations Relating to Money and Finance MONETARY OFFICES, DEPARTMENT OF THE TREASURY PORTFOLIO INVESTMENT SURVEY REPORTING § 129.5 Confidentiality. (a) Information collected...

31 CFR 129.5 - Confidentiality.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Confidentiality. 129.5 Section 129.5 Money and Finance: Treasury Regulations Relating to Money and Finance MONETARY OFFICES, DEPARTMENT OF THE TREASURY PORTFOLIO INVESTMENT SURVEY REPORTING § 129.5 Confidentiality. (a) Information collected...

Using software agents to preserve individual health data confidentiality in micro-scale geographical analyses.

PubMed

Kamel Boulos, Maged N; Cai, Qiang; Padget, Julian A; Rushton, Gerard

2006-04-01

Confidentiality constraints often preclude the release of disaggregate data about individuals, which limits the types and accuracy of the results of geographical health analyses that could be done. Access to individually geocoded (disaggregate) data often involves lengthy and cumbersome procedures through review boards and committees for approval (and sometimes is not possible). Moreover, current data confidentiality-preserving solutions compatible with fine-level spatial analyses either lack flexibility or yield less than optimal results (because of confidentiality-preserving changes they introduce to disaggregate data), or both. In this paper, we present a simulation case study to illustrate how some analyses cannot be (or will suffer if) done on aggregate data. We then quickly review some existing data confidentiality-preserving techniques, and move on to explore a solution based on software agents with the potential of providing flexible, controlled (software-only) access to unmodified confidential disaggregate data and returning only results that do not expose any person-identifiable details. The solution is thus appropriate for micro-scale geographical analyses where no person-identifiable details are required in the final results (i.e., only aggregate results are needed). Our proposed software agent technique also enables post-coordinated analyses to be designed and carried out on the confidential database(s), as needed, compared to a more conventional solution based on the Web Services model that would only support a rigid, pre-coordinated (pre-determined) and rather limited set of analyses. The paper also provides an exploratory discussion of mobility, security, and trust issues associated with software agents, as well as possible directions/solutions to address these issues, including the use of virtual organizations. Successful partnerships between stakeholder organizations, proper collaboration agreements, clear policies, and unambiguous interpretations

31 CFR 129.5 - Confidentiality.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Confidentiality. 129.5 Section 129.5 Money and Finance: Treasury Regulations Relating to Money and Finance PORTFOLIO INVESTMENT SURVEY REPORTING § 129.5 Confidentiality. (a) Information collected pursuant to the Act will be kept in confidence...

40 CFR 57.606 - Confidentiality.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Confidentiality. 57.606 Section 57.606 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PRIMARY... section 114 of the Act and 40 CFR part 2 shall govern the confidentiality of any data or information...

Fracture resistance of simulated immature tooth roots reinforced with MTA or restorative materials.

PubMed

Karapinar-Kazandag, Meric; Basrani, Bettina; Tom-Kun Yamagishi, Valerie; Azarpazhooh, Amir; Friedman, Shimon

2016-04-01

Immature endodontically treated teeth may require reinforcing to reduce the risk of root fracture. This study assessed the fracture resistance of simulated immature tooth roots reinforced with mineral trioxide aggregate (MTA) or two composite resin (CR) materials. One hundred extracted roots of mature human maxillary incisors were decoronated and sectioned 9 mm further apically from the decoronation line and randomly divided into five groups (n = 20). In Group 1 (negative control), roots received no treatment. In groups 2-5, canals were enlarged to 2.1 mm diameter to simulate immature roots, dressed with calcium hydroxide (Ca(OH)2 ) and incubated for 7 days. After removal of Ca(OH)2 , canals in Group 2 (positive control) were left unfilled. Canals in groups 3, 4 and 5 were filled with MTA, BisFil 2B flowable CR or BisFil II posterior CR, respectively. After further incubation for 30 days, specimens were embedded in acrylic cylinders and horizontally loaded in a universal testing machine at cross head speed of 5 mm min(-1) until fracture occurred. Load (N) at and pattern of fracture were recorded. Load at fracture was significantly lower (t-test, P = 0.003) in Group 2 (630 ± 199.12) than in Group 1 (896.98 ± 311.79). It did not differ significantly among groups 1, 3, 4 and 5 (anova, P > 0.07). Pattern of fracture did not differ among the groups either. Within the limitations of this study, root canal filling with MTA and two CR materials affected reinforcement of simulated immature roots to levels comparable with intact roots. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

The inadvertent breach of confidentiality.

PubMed

Erlen, J A

1998-01-01

Patients believe that personal information that they share with their health care providers will be kept strictly confidential. Safeguarding a confidence has been and continues to be an expected professional behavior. Yet, a common ethical problem that nurses face in their everyday practice is the inadvertent disclosure of private information about particular patients to individuals who have no need for this information. This article discusses the inadvertent breach of confidentiality and its related ethical concepts: privacy, respect for persons, trust and fidelity, and the potential for harm or injury. Recommendations are provided to enable nurses to avoid and manage situations that involve an inadvertent breach of confidentiality.

A qualitative study of women's views on medical confidentiality

PubMed Central

Jenkins, G; Merz, J; Sankar, P

2005-01-01

Context: The need to reinvigorate medical confidentiality protections is recognised as an important objective in building patient trust necessary for successful health outcomes. Little is known about patient understanding and expectations from medical confidentiality. Objective: To identify and describe patient views of medical confidentiality and to assess provisionally the range of these views. Design: Qualitative study using indepth, open ended face-to-face interviews. Setting: Southeastern Pennsylvania and southern New Jersey, USA. Participants: A total of 85 women interviewed at two clinical sites and three community/research centres. Main outcome measures: Subjects' understanding of medical confidentiality, beliefs about the handling of confidential information and concerns influencing disclosure of information to doctors. Results: The subjects defined medical confidentiality as the expectation that something done or said would be kept "private" but differed on what information was confidential and the basis and methods for protecting information. Some considered all medical information as confidential and thought confidentiality protections functioned to limit its circulation to medical uses and reimbursement needs. Others defined only sensitive or potentially stigmatising information as confidential. Many of these also defined medical confidentiality as a strict limit prohibiting information release, although some noted that specific permission or urgent need could override this limit. Conclusions: Patients share a basic understanding of confidentiality as protection of information, but some might have expectations that are likely not met by current practice nor anticipated by doctors. Doctors should recognise that patients might have their own medical confidentiality models. They should address divergences from current practice and provide support to those who face emotional or practical obstacles to self-revelation. PMID:16131550

Delivery of Confidential Care to Adolescent Males

PubMed Central

Rubin, Susan E.; McKee, M. Diane; Campos, Giselle; O’Sullivan, Lucia F.

2014-01-01

Purpose Primary care providers’ (PCPs’) provision of time alone with an adolescent without the parents present (henceforth referred to as “confidential care”) has a significant impact on adolescents’ disclosure of risk behavior. To inform the development of interventions to improve PCPs’ delivery of confidential care, we obtained the perspectives of adolescent males and their mothers about the health care concerns of adolescent males and the provision of confidential care. Methods This focus-group study (5 groups: 2 with adolescent males and 2 with mothers) used standard qualitative methods for analysis. We recruited mother/son dyads who had been seen at urban primary care practices. Results Adolescents’ health concerns focused on pregnancy and sexually transmitted infections; mothers took a broader view. Many adolescents felt that PCPs often delivered safe sex counseling in a superficial, impersonal manner that did not add much value to what they already knew, and that their PCP’s principal role was limited to performing sexually transmitted infection testing. Though adolescents cited a number of advantages of confidential care and disclosure, they expressed some general mistrust in PCPs and concerns about limits of confidentiality. Rapport and relationship building with their PCP are key elements to adolescents’ comfort and increased disclosure. Overall, mothers viewed confidential care positively, especially in the context of continuity of care, but many felt excluded. Conclusions To increase adolescents’ perception of the relevance of primary care and to foster disclosure during health encounters, our participants described the critical nature of a strong doctor–patient relationship and positive physician demeanor and personalized messages, especially in the context of a continuity relationship. Regular, routine inclusion of confidential care time starting early in adolescence, as well as discussion of the purpose and limitations of

42 CFR 59.11 - Confidentiality.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Confidentiality. 59.11 Section 59.11 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR FAMILY PLANNING SERVICES Project Grants for Family Planning Services § 59.11 Confidentiality. All information as to personal facts...

42 CFR 59.11 - Confidentiality.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Confidentiality. 59.11 Section 59.11 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR FAMILY PLANNING SERVICES Project Grants for Family Planning Services § 59.11 Confidentiality. All information as to personal facts...

42 CFR 59.11 - Confidentiality.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Confidentiality. 59.11 Section 59.11 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR FAMILY PLANNING SERVICES Project Grants for Family Planning Services § 59.11 Confidentiality. All information as to personal facts...

42 CFR 59.11 - Confidentiality.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Confidentiality. 59.11 Section 59.11 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR FAMILY PLANNING SERVICES Project Grants for Family Planning Services § 59.11 Confidentiality. All information as to personal facts...

42 CFR 59.11 - Confidentiality.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Confidentiality. 59.11 Section 59.11 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR FAMILY PLANNING SERVICES Project Grants for Family Planning Services § 59.11 Confidentiality. All information as to personal facts...

15 CFR 718.3 - Disclosure of confidential business information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Disclosure of confidential business... CONFIDENTIAL BUSINESS INFORMATION § 718.3 Disclosure of confidential business information. (a) General... Information Act, as appropriate. (b) Disclosure of confidential business information contained in advance...

15 CFR 718.3 - Disclosure of confidential business information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Disclosure of confidential business... CONFIDENTIAL BUSINESS INFORMATION § 718.3 Disclosure of confidential business information. (a) General... Information Act, as appropriate. (b) Disclosure of confidential business information contained in advance...

15 CFR 718.3 - Disclosure of confidential business information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Disclosure of confidential business... CONFIDENTIAL BUSINESS INFORMATION § 718.3 Disclosure of confidential business information. (a) General... Information Act, as appropriate. (b) Disclosure of confidential business information contained in advance...

Development of the foremost light-curable calcium-silicate MTA cement as root-end in oral surgery. Chemical-physical properties, bioactivity and biological behavior.

PubMed

Gandolfi, Maria Giovanna; Taddei, Paola; Siboni, Francesco; Modena, Enrico; Ciapetti, Gabriela; Prati, Carlo

2011-07-01

An innovative light-curable calcium-silicate cement containing a HEMA-TEGDMA-based resin (lc-MTA) was designed to obtain a bioactive fast setting root-end filling and root repair material. lc-MTA was tested for setting time, solubility, water absorption, calcium release, alkalinizing activity (pH of soaking water), bioactivity (apatite-forming ability) and cell growth-proliferation. The apatite-forming ability was investigated by micro-Raman, ATR-FTIR and ESEM/EDX after immersion at 37°C for 1-28 days in DPBS or DMEM+FBS. The marginal adaptation of cement in root-end cavities of extracted teeth was assessed by ESEM/EDX, and the viability of Saos-2 cell on cements was evaluated. lc-MTA demonstrated a rapid setting time (2min), low solubility, high calcium release (150-200ppm) and alkalinizing power (pH 10-12). lc-MTA proved the formation of bone-like apatite spherulites just after 1 day. Apatite precipitates completely filled the interface porosities and created a perfect marginal adaptation. lc-MTA allowed Saos-2 cell viability and growth and no compromising toxicity was exerted. HEMA-TEGDMA creates a polymeric network able to stabilize the outer surface of the cement and a hydrophilic matrix permeable enough to allow water absorption. SiO(-)/Si-OH groups from the mineral particles induce heterogeneous nucleation of apatite by sorption of calcium and phosphate ions. Oxygen-containing groups from poly-HEMA-TEGDMA provide additional apatite nucleating sites through the formation of calcium chelates. The strong novelty was that the combination of a hydraulic calcium-silicate powder and a poly-HEMA-TEGDMA hydrophilic resin creates the conditions (calcium release and functional groups able to chelate Ca ions) for a bioactive fast setting light-curable material for clinical applications in dental and maxillofacial surgery. The first and unique/exclusive light-curable calcium-silicate MTA cement for endodontics and root-end application was created, with a potential

Postmortem Confidentiality: An Ethical Issue

ERIC Educational Resources Information Center

Bradley, Loretta J.; Hendricks, Bret; Kabell, Douglas R.

2011-01-01

In an era of increased need and expectation for confidentiality, the counseling record of the deceased client challenges confidentiality. Using ethical codes and legal mandates, the authors explore whether the counseling record of a deceased client should be released when the client's will and the client's counseling records are silent on this…

29 CFR 1691.3 - Confidentiality.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 4 2011-07-01 2011-07-01 false Confidentiality. 1691.3 Section 1691.3 Labor Regulations.... When an agency receives information obtained by EEOC, the agency shall observe the confidentiality requirements of sections 706(b) and 709(e) of title VII as would EEOC, except in cases where the agency...

29 CFR 1691.3 - Confidentiality.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false Confidentiality. 1691.3 Section 1691.3 Labor Regulations.... When an agency receives information obtained by EEOC, the agency shall observe the confidentiality requirements of sections 706(b) and 709(e) of title VII as would EEOC, except in cases where the agency...

29 CFR 1691.3 - Confidentiality.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 4 2014-07-01 2014-07-01 false Confidentiality. 1691.3 Section 1691.3 Labor Regulations.... When an agency receives information obtained by EEOC, the agency shall observe the confidentiality requirements of sections 706(b) and 709(e) of title VII as would EEOC, except in cases where the agency...

29 CFR 1691.3 - Confidentiality.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 4 2012-07-01 2012-07-01 false Confidentiality. 1691.3 Section 1691.3 Labor Regulations.... When an agency receives information obtained by EEOC, the agency shall observe the confidentiality requirements of sections 706(b) and 709(e) of title VII as would EEOC, except in cases where the agency...

Effects of LED phototherapy on bone defects grafted with MTA, bone morphogenetic proteins, and guided bone regeneration in a rodent model: a description of the bone repair by light microscopy

NASA Astrophysics Data System (ADS)

Pinheiro, Antonio Luiz B.; Aciole, Gilberth T. S.; Soares, Luiz G. P.; Correia, Neandder A.; N. dos Santos, Jean

2011-03-01

We carried out a histological analysis on surgical bone defects grafted or not with MTA, treated or not with LED, BMPs and GBR. We have used several models to assess the effects of laser on bone. Benefits of the isolated or combined use them on bone healing has been suggested. There is no previous report on their association with LED light. 90 rats were divided into 10 groups. On Groups II and I the defect were filled with the clot. On Group II, were further irradiated. On groups III-VI, defect was filled with MTA + Collagen gel (III); animals of group IV were further irradiated. On groups V and VI, the defects filled with the MTA were covered with a membrane. Animals of Group VI were further irradiated. On Groups VII and VIII a pool of BMPs was added to the MTA and was further irradiated. On groups IX and X, the MTA + BMP graft was covered with a membrane. On group X, the defect was further irradiated. LED (λ850 +/- 10nm, 150mW, A= 0.5cm2, 54s, 0.3W/cm2, 16 J/cm2) was applied at 48 h intervals during 15 days. Specimens were taken, processed, cut and stained with H&E and Sirius red and underwent histological analysis. The results showed that MTA seemed not being affected by LED light. However, its use positively affected healing around the graft. It is concluded that MTA is not affected by the LED light due to it characteristics, but beneficial results with LED usage was found.

29 CFR 1641.3 - Confidentiality.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 4 2014-07-01 2014-07-01 false Confidentiality. 1641.3 Section 1641.3 Labor Regulations... SUBCONTRACTS § 1641.3 Confidentiality. When the Department of Labor receives information obtained by EEOC, the... of the Civil Rights Act of 1964, as incorporated by section 107(a) of the ADA, as would EEOC, except...

29 CFR 1641.3 - Confidentiality.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false Confidentiality. 1641.3 Section 1641.3 Labor Regulations... SUBCONTRACTS § 1641.3 Confidentiality. When the Department of Labor receives information obtained by EEOC, the... of the Civil Rights Act of 1964, as incorporated by section 107(a) of the ADA, as would EEOC, except...

29 CFR 1641.3 - Confidentiality.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 4 2013-07-01 2013-07-01 false Confidentiality. 1641.3 Section 1641.3 Labor Regulations... SUBCONTRACTS § 1641.3 Confidentiality. When the Department of Labor receives information obtained by EEOC, the... of the Civil Rights Act of 1964, as incorporated by section 107(a) of the ADA, as would EEOC, except...

29 CFR 1641.3 - Confidentiality.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 4 2011-07-01 2011-07-01 false Confidentiality. 1641.3 Section 1641.3 Labor Regulations... SUBCONTRACTS § 1641.3 Confidentiality. When the Department of Labor receives information obtained by EEOC, the... of the Civil Rights Act of 1964, as incorporated by section 107(a) of the ADA, as would EEOC, except...

29 CFR 1641.3 - Confidentiality.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 4 2012-07-01 2012-07-01 false Confidentiality. 1641.3 Section 1641.3 Labor Regulations... SUBCONTRACTS § 1641.3 Confidentiality. When the Department of Labor receives information obtained by EEOC, the... of the Civil Rights Act of 1964, as incorporated by section 107(a) of the ADA, as would EEOC, except...

16 CFR 1102.24 - Designation of confidential information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... ACT REGULATIONS PUBLICLY AVAILABLE CONSUMER PRODUCT SAFETY INFORMATION DATABASE Procedural... allegedly confidential information is not placed in the database, a request for designation of confidential... publication in the Database until it makes a determination regarding confidential treatment. (e) Assistance...

16 CFR 1102.24 - Designation of confidential information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... ACT REGULATIONS PUBLICLY AVAILABLE CONSUMER PRODUCT SAFETY INFORMATION DATABASE Procedural... allegedly confidential information is not placed in the database, a request for designation of confidential... publication in the Database until it makes a determination regarding confidential treatment. (e) Assistance...

40 CFR 86.1116-87 - Treatment of confidential information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Treatment of confidential information... Vehicles, Including Light-Duty Trucks § 86.1116-87 Treatment of confidential information. (a) Any... confidential treatment as provided by 40 CFR part 2, subpart B. (b) Any claim of confidentiality must accompany...

16 CFR 1102.24 - Designation of confidential information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... ACT REGULATIONS PUBLICLY AVAILABLE CONSUMER PRODUCT SAFETY INFORMATION DATABASE (Eff. Jan. 10, 2011... allegedly confidential information is not placed in the database, a request for designation of confidential... publication in the Database until it makes a determination regarding confidential treatment. (e) Assistance...

Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-β-catenin signaling axis in a microRNA-34a dependent manner

PubMed Central

Avtanski, Dimiter B.; Nagalingam, Arumugam; Kuppusamy, Panjamurthy; Bonner, Michael Y.; Arbiser, Jack L.; Saxena, Neeraj K.; Sharma, Dipali

2015-01-01

Obesity greatly influences risk, progression and prognosis of breast cancer. As molecular effects of obesity are largely mediated by adipocytokine leptin, finding effective novel strategies to antagonize neoplastic effects of leptin is desirable to disrupt obesity-cancer axis. Present study is designed to test the efficacy of honokiol (HNK), a bioactive polyphenol from Magnolia grandiflora, against oncogenic actions of leptin and systematically elucidate the underlying mechanisms. Our results show that HNK significantly inhibits leptin-induced breast-cancer cell-growth, invasion, migration and leptin-induced breast-tumor-xenograft growth. Using a phospho-kinase screening array, we discover that HNK inhibits phosphorylation and activation of key molecules of leptin-signaling-network. Specifically, HNK inhibits leptin-induced Wnt1-MTA1-β-catenin signaling in vitro and in vivo. Finally, an integral role of miR-34a in HNK-mediated inhibition of Wnt1-MTA1-β-catenin axis was discovered. HNK inhibits Stat3 phosphorylation, abrogates its recruitment to miR-34a promoter and this release of repressor-Stat3 results in miR-34a activation leading to Wnt1-MTA1-β-catenin inhibition. Accordingly, HNK treatment inhibited breast tumor growth in diet-induced-obese mouse model (exhibiting high leptin levels) in a manner associated with activation of miR-34a and inhibition of MTA1-β-catenin. These data provide first in vitro and in vivo evidence for the leptin-antagonist potential of HNK revealing a crosstalk between HNK and miR34a and Wnt1-MTA1-β-catenin axis. PMID:26036628

49 CFR 537.12 - Confidential information.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 6 2012-10-01 2012-10-01 false Confidential information. 537.12 Section 537.12 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AUTOMOTIVE FUEL ECONOMY REPORTS § 537.12 Confidential information...

49 CFR 537.12 - Confidential information.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 6 2011-10-01 2011-10-01 false Confidential information. 537.12 Section 537.12 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AUTOMOTIVE FUEL ECONOMY REPORTS § 537.12 Confidential information...

49 CFR 537.12 - Confidential information.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 6 2014-10-01 2014-10-01 false Confidential information. 537.12 Section 537.12 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AUTOMOTIVE FUEL ECONOMY REPORTS § 537.12 Confidential information...

49 CFR 537.12 - Confidential information.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 6 2013-10-01 2013-10-01 false Confidential information. 537.12 Section 537.12 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AUTOMOTIVE FUEL ECONOMY REPORTS § 537.12 Confidential information...

7 CFR 28.960 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Confidential information. 28.960 Section 28.960 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... Tests § 28.960 Confidential information. No information concerning individual tests under the...

Biocompatibility and setting time of CPM-MTA and white Portland cement clinker with or without calcium sulfate.

PubMed

Bramante, Clovis Monteiro; Kato, Marcia Magro; Assis, Gerson Francisco de; Duarte, Marco Antonio Hungaro; Bernardineli, Norberti; Moraes, Ivaldo Gomes de; Garcia, Roberto Brandão; Ordinola-Zapata, Ronald; Bramante, Alexandre Silva

2013-01-01

To evaluate the biocompatibility and the setting time of Portland cement clinker with or without 2% or 5% calcium sulfate and MTA-CPM. Twenty-four mice (Rattus norvegicus) received subcutaneously polyethylene tubes filled with Portland cement clinker with or without 2% or 5% calcium sulfate and MTA. After 15, 30 and 60 days of implantation, the animals were killed and specimens were prepared for microscopic analysis. For evaluation of the setting time, each material was analyzed using Gilmore needles weighing 113.5 g and 456.5 g, according to the ASTM specification Number C266-08 guideline. Data were analyzed by ANOVA and Tukey's test for setting time and Kruskal-Wallis and Dunn test for biocompatibility at 5% significance level. Histologic observation showed no statistically significant difference of biocompatibility (p>0.05) among the materials in the subcutaneous tissues. For the setting time, clinker without calcium sulfate showed the shortest initial and final setting times (6.18 s/21.48 s), followed by clinker with 2% calcium sulfate (9.22 s/25.33 s), clinker with 5% calcium sulfate (10.06 s/42.46 s) and MTA (15.01 s/42.46 s). All the tested materials showed biocompatibility and the calcium sulfate absence shortened the initial and final setting times of the white Portland cement clinker.

40 CFR 704.7 - Confidential business information claims.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Confidential business information... Provisions for Section 8(a) Information-Gathering Rules § 704.7 Confidential business information claims. (a) Any person submitting a notice under this rule may assert a business confidentiality claim covering...

40 CFR 704.7 - Confidential business information claims.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Confidential business information... Provisions for Section 8(a) Information-Gathering Rules § 704.7 Confidential business information claims. (a) Any person submitting a notice under this rule may assert a business confidentiality claim covering...

40 CFR 704.7 - Confidential business information claims.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Confidential business information... Provisions for Section 8(a) Information-Gathering Rules § 704.7 Confidential business information claims. (a) Any person submitting a notice under this rule may assert a business confidentiality claim covering...

12 CFR 978.5 - Storage of confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Storage of confidential information. 978.5... OPERATIONS AND AUTHORITIES BANK REQUESTS FOR INFORMATION § 978.5 Storage of confidential information. Each Bank shall: (a) Store all identified confidential information in secure storage areas or filing...

The Confidentiality of Interlibrary Loan Records.

ERIC Educational Resources Information Center

Nolan, Christopher W.

1993-01-01

Discusses potential problems for confidentiality within interlibrary loan requests, outlines legal issues related to confidentiality, and proposes guidelines intended to protect library users' rights to privacy. Interlibrary loan documentation procedures are considered; laws and professional standards are reviewed; and the disposition of…

7 CFR 1206.107 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential information. 1206.107 Section 1206.107 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... INFORMATION Referendum Procedures. § 1206.107 Confidential information. The ballots and other information or...

15 CFR 705.6 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... EFFECT OF IMPORTED ARTICLES ON THE NATIONAL SECURITY § 705.6 Confidential information. (a) Any... the investigation that would disclose national security classified information or business... Security Classified” or “Business Confidential,” as appropriate, marked at the top of each sheet. Any...

31 CFR 9.6 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 9.6 Money and Finance: Treasury Office of the Secretary of the Treasury EFFECTS OF IMPORTED ARTICLES ON THE NATIONAL SECURITY § 9.6 Confidential information. Information submitted in confidence which... marked “Business Confidential.” [40 FR 50717, Oct. 31, 1975] ...

7 CFR 1150.278 - Confidential treatment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Confidential treatment. 1150.278 Section 1150.278 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... of Milk Producer Organizations § 1150.278 Confidential treatment. All documents and other information...

7 CFR 54.1033 - Confidential treatment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Confidential treatment. 54.1033 Section 54.1033 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... and Poultry Products § 54.1033 Confidential treatment. Every design review specialist providing...

7 CFR 983.9 - Confidential data or information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Confidential data or information. 983.9 Section 983.9..., ARIZONA, AND NEW MEXICO Definitions § 983.9 Confidential data or information. Confidential data or information submitted to the committee consists of data or information constituting a trade secret or...

7 CFR 983.9 - Confidential data or information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Confidential data or information. 983.9 Section 983.9..., ARIZONA, AND NEW MEXICO Definitions § 983.9 Confidential data or information. Confidential data or information submitted to the committee consists of data or information constituting a trade secret or...

7 CFR 983.9 - Confidential data or information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 8 2014-01-01 2014-01-01 false Confidential data or information. 983.9 Section 983.9..., ARIZONA, AND NEW MEXICO Definitions § 983.9 Confidential data or information. Confidential data or information submitted to the committee consists of data or information constituting a trade secret or...

7 CFR 983.9 - Confidential data or information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 8 2012-01-01 2012-01-01 false Confidential data or information. 983.9 Section 983.9..., ARIZONA, AND NEW MEXICO Definitions § 983.9 Confidential data or information. Confidential data or information submitted to the committee consists of data or information constituting a trade secret or...

Confidentiality Revisited: A Response to Manhal-Baugus (1996).

ERIC Educational Resources Information Center

Doyle, Kevin

1998-01-01

Reviews the issues relating to confidentiality raised by Manhal-Baugus (1996), identifies problem areas from the 1996 article, and offers additional information about confidentiality not included in the article. Chemical dependency counselors are urged to consider the federal law covering confidentiality of alcohol- and drug-abuse patient records…

Results of tests of MTA-2 TPS on the SRB hold-down bolt blast container

NASA Technical Reports Server (NTRS)

Dean, W. G.

1982-01-01

The four solid rocket booster (SRB) hold-down posts are fastened to the mobile launch platform (MLP) with four large nuts. At liftoff the nuts are split with explosive changes to release the SRB/Shuttle. A blast container is placed over the nuts to protect the vehicle from flying debris. The blast container is a reusable part and has to be protected from aerodynamic heating during flight. The thermal protection system (TPS) used to protect these blast containers is cork. Fitting the flat cork sheet to this hemispherical shaped blast container is both time consuming and expensive. Another problem is removing the charred cork and epoxy glue from the blast containers. Replacements of this cork with another TPS material such as MTA-2 was examined. Heating rates along the centerline of the forward facing areas of the blast container were determined. The feasibility of using 1/2 in. MTA-2 on the SRB blast containers for protection from ascent, plume impingement and reentry heating is demonstrated.

37 CFR 380.5 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Confidential information. 380... information. (a) Definition. For purposes of this part, “Confidential Information” shall include the statements of account and any information contained therein, including the amount of royalty payments, and...

7 CFR 900.352 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 900.352 Section 900.352... Determining the Qualification of Cooperative Milk Marketing Associations § 900.352 Confidential information. The documents and other information submitted by an applicant association and otherwise obtained by...

37 CFR 262.5 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Confidential information. 262... information. (a) Definition. For purposes of this part, “Confidential Information” shall include the statements of account, any information contained therein, including the amount of royalty payments, and any...

40 CFR 158.33 - Confidential data.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Confidential data. 158.33 Section 158.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES General Provisions § 158.33 Confidential data. (a) Definitions. For the purposes of...

40 CFR 158.33 - Confidential data.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Confidential data. 158.33 Section 158.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES General Provisions § 158.33 Confidential data. (a) Definitions. For the purposes of...

7 CFR 1260.203 - Confidential treatment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential treatment. 1260.203 Section 1260.203 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Promotion and Research Order Reports, Books and Records § 1260.203 Confidential treatment. All information...

7 CFR 1250.354 - Confidential treatment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential treatment. 1250.354 Section 1250.354 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Research and Promotion Order Reports, Books, and Records § 1250.354 Confidential treatment. (a) All...

7 CFR 1160.403 - Confidential treatment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Confidential treatment. 1160.403 Section 1160.403 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... Order Reports, Books and Records § 1160.403 Confidential treatment. (a) All persons, including agents...

7 CFR 1218.62 - Confidential treatment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential treatment. 1218.62 Section 1218.62 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... § 1218.62 Confidential treatment. All information obtained from books, records, or reports under the Act...

7 CFR 1221.127 - Confidential treatment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential treatment. 1221.127 Section 1221.127 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Confidential treatment. All information obtained from books, records, or reports under the Act and this part...

7 CFR 1150.173 - Confidential treatment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Confidential treatment. 1150.173 Section 1150.173 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... Order Reports, Books and Records § 1150.173 Confidential treatment. All information obtained from such...

7 CFR 1212.72 - Confidential treatment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential treatment. 1212.72 Section 1212.72 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Confidential treatment. All information obtained from books, records, or reports under the Act and this part...

7 CFR 1205.340 - Confidential treatment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential treatment. 1205.340 Section 1205.340 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Cotton Research and Promotion Order Reports, Books, and Records § 1205.340 Confidential treatment. All...

7 CFR 1230.82 - Confidential treatment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential treatment. 1230.82 Section 1230.82 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... § 1230.82 Confidential treatment. All information obtained from the books, records or reports required to...

7 CFR 1219.63 - Confidential treatment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential treatment. 1219.63 Section 1219.63 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... § 1219.63 Confidential treatment. (a) All information obtained from the books, records, or reports under...

7 CFR 1220.243 - Confidential treatment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential treatment. 1220.243 Section 1220.243 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Confidential treatment. Except as otherwise provided in the Act, financial or commercial information that is...

7 CFR 1206.62 - Confidential treatment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential treatment. 1206.62 Section 1206.62 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Confidential treatment. All information obtained from books, records, or reports under the Act and this part...

31 CFR 9.6 - Confidential information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Confidential information. 9.6 Section 9.6 Money and Finance: Treasury Office of the Secretary of the Treasury EFFECTS OF IMPORTED ARTICLES... marked “Business Confidential.” [40 FR 50717, Oct. 31, 1975] ...

31 CFR 9.6 - Confidential information.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Confidential information. 9.6 Section 9.6 Money and Finance: Treasury Office of the Secretary of the Treasury EFFECTS OF IMPORTED ARTICLES... marked “Business Confidential.” [40 FR 50717, Oct. 31, 1975] ...

7 CFR 932.63 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 932.63 Section 932.63... Regulating Handling Reports and Records § 932.63 Confidential information. All reports and information... any person, other than the Secretary upon request therefor, data, or information obtained or extracted...

7 CFR 989.75 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 989.75 Section 989.75... GROWN IN CALIFORNIA Order Regulating Handling Reports and Records § 989.75 Confidential information. All... to no person, except the Secretary upon request therefor, data or information obtained or extracted...

7 CFR 993.71 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 993.71 Section 993.71... CALIFORNIA Order Regulating Handling Reports and Books and Other Records § 993.71 Confidential information... information constituting a trade secret or disclosing of the trade position, financial condition, or business...

7 CFR 996.72 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 996.72 Section 996.72... Confidential information. All reports and records furnished or submitted by handlers and importers to USDA which include data or information constituting a trade secret or disclosing a trade position, financial...

7 CFR 926.19 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 926.19 Section 926.19... Confidential information. All reports and records furnished or submitted pursuant to this part which include data or information constituting a trade secret or disclosing the trade position or financial condition...

49 CFR 537.12 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 6 2010-10-01 2010-10-01 false Confidential information. 537.12 Section 537.12... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AUTOMOTIVE FUEL ECONOMY REPORTS § 537.12 Confidential information. (a) Information made available under § 537.11 for public inspection does not include information for...

12 CFR 1070.44 - Disclosure of confidential consumer complaint information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Disclosure of confidential consumer complaint... RECORDS AND INFORMATION Confidential Information § 1070.44 Disclosure of confidential consumer complaint... disclose confidential consumer complaint information as it deems necessary to investigate, resolve, or...

12 CFR 1070.44 - Disclosure of confidential consumer complaint information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 12 Banks and Banking 9 2014-01-01 2014-01-01 false Disclosure of confidential consumer complaint... RECORDS AND INFORMATION Confidential Information § 1070.44 Disclosure of confidential consumer complaint... disclose confidential consumer complaint information as it deems necessary to investigate, resolve, or...

12 CFR 1070.44 - Disclosure of confidential consumer complaint information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Disclosure of confidential consumer complaint... RECORDS AND INFORMATION Confidential Information § 1070.44 Disclosure of confidential consumer complaint... disclose confidential consumer complaint information as it deems necessary to investigate, resolve, or...

7 CFR 982.70 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 982.70 Section 982.70... WASHINGTON Order Regulating Handling Records and Reports § 982.70 Confidential information. All reports and records furnished or submitted by handlers to the Board, which include data or information constituting a...

7 CFR 985.63 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 985.63 Section 985.63... Confidential information. All reports and records furnished or submitted by handlers to, or obtained by the employees of the Committee, which contain data or information constituting a trade secret or disclosing the...

7 CFR 929.65 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 929.65 Section 929.65... Confidential information. All reports and records furnished or submitted by handlers to the committee and its authorized agents which include data or information constituting a trade secret or disclosing the trade...

7 CFR 984.79 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 984.79 Section 984.79... Regulating Handling Reports, Books, and Other Records § 984.79 Confidential information. All reports and records submitted by handlers to the Board, which include data or information constituting a trade secret...

7 CFR 930.73 - Confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 930.73 Section 930.73... Handling Reports and Records § 930.73 Confidential information. All reports and records furnished or submitted by handlers to the Board and its authorized agents which include data or information constituting...

42 CFR 2.13 - Confidentiality restrictions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS General Provisions § 2.13 Confidentiality restrictions... place where only alcohol or drug abuse diagnosis, treatment, or referral is provided may be acknowledged... facility if the facility is not publicy identified as only an alcohol or drug abuse diagnosis, treatment or...

42 CFR 2.13 - Confidentiality restrictions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS General Provisions § 2.13 Confidentiality restrictions... place where only alcohol or drug abuse diagnosis, treatment, or referral is provided may be acknowledged... facility if the facility is not publicy identified as only an alcohol or drug abuse diagnosis, treatment or...

42 CFR 2.13 - Confidentiality restrictions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS General Provisions § 2.13 Confidentiality restrictions... place where only alcohol or drug abuse diagnosis, treatment, or referral is provided may be acknowledged... facility if the facility is not publicy identified as only an alcohol or drug abuse diagnosis, treatment or...

42 CFR 2.13 - Confidentiality restrictions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS General Provisions § 2.13 Confidentiality restrictions... place where only alcohol or drug abuse diagnosis, treatment, or referral is provided may be acknowledged... facility if the facility is not publicy identified as only an alcohol or drug abuse diagnosis, treatment or...

42 CFR 2.13 - Confidentiality restrictions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS General Provisions § 2.13 Confidentiality restrictions... place where only alcohol or drug abuse diagnosis, treatment, or referral is provided may be acknowledged... facility if the facility is not publicy identified as only an alcohol or drug abuse diagnosis, treatment or...

Follow-Up of Young Adults With ADHD in the MTA: Design and Methods for Qualitative Interviews.

PubMed

Weisner, Thomas S; Murray, Desiree W; Jensen, Peter S; Mitchell, John T; Swanson, James M; Hinshaw, Stephen P; Wells, Karen; Hechtman, Lily; Molina, Brooke S G; Arnold, L Eugene; Sorensen, Page; Stehli, Annamarie

2017-06-01

Qualitative interviews with 183 young adults (YA) in the follow-up of the Multimodal Treatment Study of Children With and Without ADHD (MTA) provide rich information on beliefs and expectations regarding ADHD, life's turning points, medication use, and substance use (SU). Participants from four MTA sites were sampled to include those with persistent and atypically high SU, and a local normative comparison group (LNCG). Respondents were encouraged to "tell their story" about their lives, using a semistructured conversational interview format. Interviews were reliably coded for interview topics. ADHD youth more often desisted from SU because of seeing others going down wrong paths due to SU. Narratives revealed very diverse accounts and explanations for SU-ADHD influences. Qualitative methods captured the perspectives of YAs regarding using substances. This information is essential for improving resilience models in drug prevention and treatment programs and for treatment development for this at-risk population.

Parent-Reported Homework Problems in the MTA Study: Evidence for Sustained Improvement with Behavioral Treatment

ERIC Educational Resources Information Center

Langberg, Joshua M.; Arnold, L. Eugene; Flowers, Amanda M.; Epstein, Jeffery N.; Altaye, Mekibib; Hinshaw, Stephen P.; Swanson, James M.; Kotkin, Ronald; Simpson, Stephen; Molina, Brooke S. G.; Jensen, Peter S.; Abikoff, Howard; Pelham, William E., Jr.; Vitiello, Benedetto; Wells, Karen C.; Hechtman, Lily

2010-01-01

Parent-report of child homework problems was examined as a treatment outcome variable in the MTA-Multimodal Treatment Study of Children with Attention-Deficit/Hyperactivity Disorder (ADHD). Five hundred seventy-nine children ages 7.0 to 9.9 were randomly assigned to either medication management, behavioral treatment, combination treatment, or…

Confidentiality and the employee assistance program professional.

PubMed

Mistretta, E F; Inlow, L B

1991-02-01

During the last two decades EAPs have offered employees confidential assessment, counseling, and referral. Many occupational health nurses have taken on the role of EAP professional or function as the liaison between the EAP counselor and the employee. The occupational health nurse involved in any EAP issue must adhere to the standards of confidentiality. The federal and state laws, company policy, and professional codes of ethics regarding these clients must be clearly understood, especially related to the issue of confidentiality.

16 CFR § 1102.24 - Designation of confidential information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... SAFETY ACT REGULATIONS PUBLICLY AVAILABLE CONSUMER PRODUCT SAFETY INFORMATION DATABASE Procedural... allegedly confidential information is not placed in the database, a request for designation of confidential... publication in the Database until it makes a determination regarding confidential treatment. (e) Assistance...

15 CFR 718.3 - Disclosure of confidential business information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Disclosure of confidential business... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS CONFIDENTIAL BUSINESS INFORMATION § 718.3 Disclosure of confidential business information. (a) General...

15 CFR 30.60 - Confidentiality of Electronic Export Information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Confidentiality of Electronic Export... § 30.60 Confidentiality of Electronic Export Information. (a) Confidential status. The EEI collected... in any form including but not limited to electronic transmission, paper printout, or certified...

15 CFR 30.60 - Confidentiality of Electronic Export Information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Confidentiality of Electronic Export... § 30.60 Confidentiality of Electronic Export Information. (a) Confidential status. The EEI collected... in any form including but not limited to electronic transmission, paper printout, or certified...

15 CFR 30.60 - Confidentiality of Electronic Export Information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Confidentiality of Electronic Export... § 30.60 Confidentiality of Electronic Export Information. (a) Confidential status. The EEI collected... in any form including but not limited to electronic transmission, paper printout, or certified...

A defense of unqualified medical confidentiality.

PubMed

Kipnis, Kenneth

2006-01-01

It is broadly held that confidentiality may be breached when doing so can avert grave harm to a third party. This essay challenges the conventional wisdom. Neither legal duties, personal morality nor personal values are sufficient to ground professional obligations. A methodology is developed drawing on core professional values, the nature of professions, and the justification for distinct professional obligations. Though doctors have a professional obligation to prevent public peril, they do not honor it by breaching confidentiality. It is shown how the protective purpose to be furthered by reporting is defeated by the practice of reporting. Hence there is no conflict between confidentiality and the professional responsibility to protect endangered third parties.

Direct pulp capping in primary molars using a resin-modified Portland cement-based material (TheraCal) compared to MTA with 12-month follow-up: a randomised clinical trial.

PubMed

Erfanparast, L; Iranparvar, P; Vafaei, A

2018-05-16

This study was to compare the success of resin-modified Portland cement-based material (TheraCal) with MTA in direct pulp capping (DPC) of primary molars. Symmetrical bilateral primary molars (92) from 46 healthy subjects aged 5-7 years were included in this split-mouth randomised clinical trial. DPC for small non-contaminated pulp exposures using either TheraCal or MTA were randomly performed in symmetrical molars. Thereafter, teeth were restored with amalgam. Clinical and radiographic evaluations were performed at 6 and 12 month follow-ups. Data were analysed using Chi square test at a significance level of 0.05. At the final follow-up session 74 teeth were available. After 12 months, the overall success rates for MTA and TheraCal were 94.5 and 91.8%, respectively. The difference between outcomes of the two groups was not statistically significant (P > 0.05). Within the limitations of the current study, radiographic and clinical findings revealed that TheraCal exhibited a comparable outcome to MTA in DPC of primary molars after 12 months.

7 CFR 400.702 - Confidentiality of submission and duration of confidentiality.

Code of Federal Regulations, 2010 CFR

2010-01-01

... approval process, may be released to the public, including any mathematical modeling and data, unless it remains confidential business information under 5 U.S.C. 552(b). (c) Any submission disapproved by the...

40 CFR 86.615-84 - Treatment of confidential information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Treatment of confidential information....615-84 Treatment of confidential information. (a) Any manufacturer may assert that some or all of the information submitted pursuant to this subpart is entitled to confidential treatment as provided by 40 CFR...

Effects of the addition of nanoparticulate calcium carbonate on setting time, dimensional change, compressive strength, solubility and pH of MTA.

PubMed

Bernardi, A; Bortoluzzi, E A; Felippe, W T; Felippe, M C S; Wan, W S; Teixeira, C S

2017-01-01

To evaluate nanoparticulate calcium carbonate (NPCC) using transmission electron microscopy and the effects of NPCC addition to MTA in regard to the setting time, dimensional change, compressive strength, solubility and pH. The experimental groups were G1 (MTA), G2 (MTA with 5% NPCC) and G3 (MTA with 10% NPCC). The tests followed ISO and ADA standards. The specimens in the dimensional change and compressive strength tests were measured immediately after setting, after 24 h and after 30 days. In the solubility test, rings filled with cement were weighed after setting and after 30 days. The pH was measured after 24 h and 30 days. The data were analysed with the ANOVA, Tukey's and Kruskal-Wallis tests (α = 5%). The setting time was reduced (P < 0.05) in samples from G2 and G3 compared to G1. After 24 h, the dimensional change was similar amongst the groups, and after 30 days, G2 was associated with less alteration than G1 and G3. There was a difference in the compressive strength (P < 0.001) after 24 h and 30 days (G1 > G2 > G3). The solubility test revealed a difference amongst the groups when the specimens were hydrated: G2 > G1 > G3 and dehydrated: G3 > G2 > G1. The pH of the groups was similar at 24 h with higher values in each group after 30 days (P < 0.05), and G2 and G3 had similar mean pH values but both were higher than G1. Nanoparticulate calcium carbonate had a cubic morphology with few impurities. The addition of nanoparticulate calcium carbonate to MTA accelerated the setting time, decreased compressive strength and, after 30 days, resulted in lower dimensional change (G2), higher solubility and a higher pH. © 2015 International Endodontic Journal. Published by John Wiley & Sons Ltd.

50 CFR 300.220 - Confidentiality of information.

Code of Federal Regulations, 2010 CFR

2010-10-01

... met: (i) The employee has a need for confidential information to further the Department of Commerce's...) Homeland and national security activities. Confidential information may be made accessible to Federal... agency only if: (i) Providing the information promotes homeland security or national security purposes...

28 CFR 40.10 - Records-nature; confidentiality.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Records-nature; confidentiality. 40.10 Section 40.10 Judicial Administration DEPARTMENT OF JUSTICE STANDARDS FOR INMATE GRIEVANCE PROCEDURES Minimum Standards for Inmate Grievance Procedures § 40.10 Records—nature; confidentiality. (a) Nature...

28 CFR 40.10 - Records-nature; confidentiality.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Records-nature; confidentiality. 40.10 Section 40.10 Judicial Administration DEPARTMENT OF JUSTICE STANDARDS FOR INMATE GRIEVANCE PROCEDURES Minimum Standards for Inmate Grievance Procedures § 40.10 Records—nature; confidentiality. (a) Nature...

28 CFR 40.10 - Records-nature; confidentiality.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Records-nature; confidentiality. 40.10 Section 40.10 Judicial Administration DEPARTMENT OF JUSTICE STANDARDS FOR INMATE GRIEVANCE PROCEDURES Minimum Standards for Inmate Grievance Procedures § 40.10 Records—nature; confidentiality. (a) Nature...

School Counselors' Constructions of Student Confidentiality

ERIC Educational Resources Information Center

Trice-Black, Shannon; Riechel, Morgan E. Kiper; Shillingford, M. Ann

2013-01-01

Confidentiality in counseling relationships helps ensure trust between clients and counselors. Yet, defining and understanding the boundaries of confidentiality in school settings is often difficult, as school counselors are engaged in multiple relationships with various stakeholders. This qualitative phenomenological study explores the…

28 CFR 40.10 - Records-nature; confidentiality.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Records-nature; confidentiality. 40.10 Section 40.10 Judicial Administration DEPARTMENT OF JUSTICE STANDARDS FOR INMATE GRIEVANCE PROCEDURES Minimum Standards for Inmate Grievance Procedures § 40.10 Records—nature; confidentiality. (a) Nature...

28 CFR 40.10 - Records-nature; confidentiality.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Records-nature; confidentiality. 40.10 Section 40.10 Judicial Administration DEPARTMENT OF JUSTICE STANDARDS FOR INMATE GRIEVANCE PROCEDURES Minimum Standards for Inmate Grievance Procedures § 40.10 Records—nature; confidentiality. (a) Nature...

42 CFR 2a.7 - Effect of Confidentiality Certificate.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Effect of Confidentiality Certificate. 2a.7 Section 2a.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS PROTECTION OF IDENTITY-RESEARCH SUBJECTS § 2a.7 Effect of Confidentiality Certificate. (a) A Confidentiality...

42 CFR 2a.7 - Effect of Confidentiality Certificate.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Effect of Confidentiality Certificate. 2a.7 Section 2a.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS PROTECTION OF IDENTITY-RESEARCH SUBJECTS § 2a.7 Effect of Confidentiality Certificate. (a) A Confidentiality...

42 CFR 2a.7 - Effect of Confidentiality Certificate.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Effect of Confidentiality Certificate. 2a.7 Section 2a.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS PROTECTION OF IDENTITY-RESEARCH SUBJECTS § 2a.7 Effect of Confidentiality Certificate. (a) A Confidentiality...

42 CFR 2a.7 - Effect of Confidentiality Certificate.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Effect of Confidentiality Certificate. 2a.7 Section 2a.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS PROTECTION OF IDENTITY-RESEARCH SUBJECTS § 2a.7 Effect of Confidentiality Certificate. (a) A Confidentiality...

42 CFR 2a.7 - Effect of Confidentiality Certificate.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Effect of Confidentiality Certificate. 2a.7 Section 2a.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS PROTECTION OF IDENTITY-RESEARCH SUBJECTS § 2a.7 Effect of Confidentiality Certificate. (a) A Confidentiality...

Law and ethics in conflict over confidentiality?

PubMed

Dickens, B M; Cook, R J

2000-09-01

Ethical principles that require the preservation of patients' confidential information are reinforced by principles found in several areas of law, such as law on contracts, negligence, defamation and fiduciary duty. However, laws sometimes compel disclosures of medical confidences, and more often may justify or excuse disclosures. Legally contentious issues concern patients' confidences regarding possible unlawful conduct, such as pregnancy termination, and the risk of spread of HIV and other infections. This article reviews the various legal bases of the duty of confidentiality, and legal challenges to the ethical obligation of non-disclosure. It addresses the justifications and limits of exchange of patients' health information among healthcare professionals and trainees, and considers legally recognized limits of confidential duties, and the scope of legitimate disclosure. An underlying theme is how to determine whether physicians are ethically justified in employing the discretion the law sometimes affords them to breach patients' expectations of confidentiality.

13 CFR 315.3 - Confidential Business Information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Confidential Business Information. 315.3 Section 315.3 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE TRADE ADJUSTMENT ASSISTANCE FOR FIRMS General Provisions § 315.3 Confidential Business Information...

19 CFR 210.5 - Confidential business information.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Confidential business information. 210.5 Section 210.5 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Rules of General Applicability § 210.5 Confidential...

12 CFR 1102.309 - Confidential treatment procedures.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Confidential treatment procedures. 1102.309 Section 1102.309 Banks and Banking FEDERAL FINANCIAL INSTITUTIONS EXAMINATION COUNCIL APPRAISER REGULATION Description of Office, Procedures, Public Information § 1102.309 Confidential treatment procedures. (a) In...

45 CFR 144.212 - Confidentiality of information.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Confidentiality of information. 144.212 Section 144.212 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS RELATING TO HEALTH INSURANCE COVERAGE Source: § 144.212 Confidentiality of...

42 CFR 35.11 - Clinical records; confidential.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Clinical records; confidential. 35.11 Section 35.11 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICAL CARE AND EXAMINATIONS HOSPITAL AND STATION MANAGEMENT General § 35.11 Clinical records; confidential. A complete...

42 CFR 35.11 - Clinical records; confidential.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Clinical records; confidential. 35.11 Section 35.11 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICAL CARE AND EXAMINATIONS HOSPITAL AND STATION MANAGEMENT General § 35.11 Clinical records; confidential. A complete...

42 CFR 35.11 - Clinical records; confidential.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Clinical records; confidential. 35.11 Section 35.11 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICAL CARE AND EXAMINATIONS HOSPITAL AND STATION MANAGEMENT General § 35.11 Clinical records; confidential. A complete...

42 CFR 35.11 - Clinical records; confidential.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Clinical records; confidential. 35.11 Section 35.11 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICAL CARE AND EXAMINATIONS HOSPITAL AND STATION MANAGEMENT General § 35.11 Clinical records; confidential. A complete...

77 FR 5721 - Surety Bond Guarantee Program-Quick Bond Guarantee Application and Agreement

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-06

... SMALL BUSINESS ADMINISTRATION 13 CFR Part 115 RIN 3245-AG39 Surety Bond Guarantee Program--Quick Bond Guarantee Application and Agreement AGENCY: Small Business Administration. ACTION: Proposed rule....gov . If you wish to submit confidential business information (CBI) as defined in the User Notice at...

19 CFR 143.4 - Confidentiality of data.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 2 2011-04-01 2011-04-01 false Confidentiality of data. 143.4 Section 143.4 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) SPECIAL ENTRY PROCEDURES Automated Broker Interface § 143.4 Confidentiality of data...

49 CFR 511.66 - Confidential business information.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 6 2012-10-01 2012-10-01 false Confidential business information. 511.66 Section... in Cases of Violation of Average Fuel Economy Standards § 511.66 Confidential business information... business information. The provisions of 15 U.S.C. 2005(d) pertaining to discretionary release by the...

49 CFR 511.66 - Confidential business information.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 6 2014-10-01 2014-10-01 false Confidential business information. 511.66 Section... in Cases of Violation of Average Fuel Economy Standards § 511.66 Confidential business information... business information. The provisions of 15 U.S.C. 2005(d) pertaining to discretionary release by the...

12 CFR 602.7 - Confidential business information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Confidential business information. 602.7... Availability of Records of the Farm Credit Administration § 602.7 Confidential business information. (a) FCA disclosure. FCA may disclose business information from a business submitter only under this section. This...

12 CFR 404.7 - Confidential business information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Confidential business information. 404.7... for Disclosure of Records Under the Freedom of Information Act. § 404.7 Confidential business information. (a) Scope. This section applies to all business information, as defined in § 404.2. Such...

12 CFR 404.7 - Confidential business information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Confidential business information. 404.7... for Disclosure of Records Under the Freedom of Information Act. § 404.7 Confidential business information. (a) Scope. This section applies to all business information, as defined in § 404.2. Such...

49 CFR 511.66 - Confidential business information.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 6 2010-10-01 2010-10-01 false Confidential business information. 511.66 Section... in Cases of Violation of Average Fuel Economy Standards § 511.66 Confidential business information... business information. The provisions of 15 U.S.C. 2005(d) pertaining to discretionary release by the...

12 CFR 602.7 - Confidential business information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Confidential business information. 602.7... Availability of Records of the Farm Credit Administration § 602.7 Confidential business information. (a) FCA disclosure. FCA may disclose business information from a business submitter only under this section. This...

50 CFR 229.11 - Confidential fisheries data.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Confidential fisheries data. 229.11... MAMMAL PROTECTION ACT OF 1972 General Provisions § 229.11 Confidential fisheries data. (a) Proprietary... which could be prejudicial or harmful, such as information or data that are identifiable with an...

50 CFR 229.11 - Confidential fisheries data.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Confidential fisheries data. 229.11... MAMMAL PROTECTION ACT OF 1972 General Provisions § 229.11 Confidential fisheries data. (a) Proprietary... which could be prejudicial or harmful, such as information or data that are identifiable with an...

16 CFR 1117.7 - Confidentiality of reports.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 1117.7 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS... Confidentiality of reports. The confidentiality provisions of section 6 of the CPSA, 15 U.S.C. 2055, apply to... protection afforded to information submitted under section 15(b), in accordance with section 6(b)(5) of the...

42 CFR 35.11 - Clinical records; confidential.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Clinical records; confidential. 35.11 Section 35.11... EXAMINATIONS HOSPITAL AND STATION MANAGEMENT General § 35.11 Clinical records; confidential. A complete clinical record shall be maintained for each patient admitted to a station or hospital of the Service. Such...

Jana: Confidential Communications on Social Networks

DTIC Science & Technology

2017-08-09

Report: Jana: Confidential Communications on Social Networks The views, opinions and/or findings contained in this report are those of the author(s) and...Confidential Communications on Social Networks Report Term: 0-Other Email: krish@ucr.edu Distribution Statement: 1-Approved for public release; distribution...is unlimited. Major Goals: The inability of users to communicate secretly on online social networking (OSN) platforms is a key obstacle to overcome

37 CFR 260.4 - Confidential information and statements of account.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Confidential information and statements of account. (a) For purposes of this part, confidential information shall include statements of account and any information pertaining to the statements of account... included on the statement of account. (d) Access to the confidential information pertaining to the royalty...

Analysis of medical confidentiality from the islamic ethics perspective.

PubMed

Tavaokkoli, Saeid Nazari; Nejadsarvari, Nasrin; Ebrahimi, Ali

2015-04-01

Confidentiality is one of the old rules of the medical profession. While emphasizing the necessity of confidentiality in religious teachings, disclosure of other's secrets to commit sin deserves punishment hereafter known. Today, progress in medical science and invention of new diagnostic and therapeutic procedures, as well as the extent of information and disclosure of the secrets of the patients, have provided more than ever. After explaining the concepts and principles of confidentiality in medical ethics, the Islamic-oriented Virtue Ethics, in a comparative review, share the differences in these two sets of ethical review and explain the issue of confidentiality. In professional medical ethics, only the behaviors of health staff are evaluated and moral evaluation of the features cannot be evaluated, but in Islamic ethics, the moral evaluation of the features that are sensual, confidentiality is more stable, without any external supervision will maintain its efficiency.

Marginal adaptation of mineral trioxide aggregate (MTA) compared with amalgam as a root-end filling material: a low-vacuum (LV) versus high-vacuum (HV) SEM study.

PubMed

Shipper, G; Grossman, E S; Botha, A J; Cleaton-Jones, P E

2004-05-01

To compare the marginal adaptation of mineral trioxide aggregate (MTA) or amalgam root-end fillings in extracted teeth under low-vacuum (LV) versus high-vacuum (HV) scanning electron microscope (SEM) viewing conditions. Root-end fillings were placed in 20 extracted single-rooted maxillary teeth. Ten root ends were filled with MTA and the other 10 root ends were filled with amalgam. Two 1 mm thick transverse sections of each root-end filling were cut 0.50 mm (top) and 1.50 mm (bottom) from the apex. Gap size was recorded at eight fixed points along the dentine-filling material interface on each section when uncoated wet (LV wet (LVW)) and dry under LV (0.3 Torr) in a JEOL JSM-5800 SEM and backscatter emission (LV dry uncoated (LVDU)). The sections were then air-dried, gold-coated and gap size was recorded once again at the fixed points under HV (10(-6) Torr; HV dry coated (HVDC)). Specimen cracking, and the size and extent of the crack were noted. Gap sizes at fixed points were smallest under LVW and largest under HVDC SEM conditions. Gaps were smallest in MTA root-end fillings. A General Linear Models Analysis, with gap size as the dependent variable, showed significant effects for extent of crack in dentine, material and viewing condition (P = 0.0001). This study showed that MTA produced a superior marginal adaptation to amalgam, and that LVW conditions showed the lowest gap size. Gap size was influenced by the method of SEM viewing. If only HV SEM viewing conditions are used for MTA and amalgam root-end fillings, a correction factor of 3.5 and 2.2, respectively, may be used to enable relative comparisons of gap size to LVW conditions.

Novel use of platelet-rich fibrin matrix and MTA as an apical barrier in the management of a failed revascularization case.

PubMed

Yadav, Pankaj; Pruthi, Preeti Jain; Naval, Ruchika Roongta; Talwar, Sangeeta; Verma, Mahesh

2015-08-01

We report management of a failed revascularization/revitalization case, which could be due to inadequate removal of biofilm and bacteria in dentinal tubules. The use of an apical matrix barrier in form of a platelet-rich fibrin (PRF) membrane for stabilization of MTA in root end apexification procedure is described. The canal was cleansed of old MTA present in the cervical third using H files, irrigated using saline and finally irrigated with 2.5% NaOCl and saline. To obtain canal disinfection, calcium hydroxide paste was temporized in the canal. In subsequent appointments, PRF was placed at the root tip followed by 5-mm apical plug with mineral trioxide aggregate. One week later, the root canal was obturated with thermoplasticized gutta-percha. A 6-month and a 2-year follow ups showed reduction of periapical radiolucency and adequately functional tooth. One-visit apexification techniques provide an alternative treatment for failed revascularization cases. Follow up confirmed complete healing periradicularly. Apexification in one step using an apical barrier of PRF and a plug of MTA can be considered a predictable treatment and may be an alternative to long-term revascularization failures. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction.

PubMed

Lu, Yimin; Wang, Jun; Liu, Lei; Yu, Lequn; Zhao, Nian; Zhou, Xingju; Lu, Xudong

2017-04-01

Non-small-cell lung cancer is one of the most lethal cancers in the worldwide. Although Paclitaxel-based combinational therapies have long been used as a standard treatment in aggressive non-small-cell lung cancers, Paclitaxel resistance emerges as a major clinical problem. It has been demonstrated that Curcumin from Curcuma longa as a traditional Chinese medicine can inhibit cancer cell proliferation. However, the role of Curcumin in Paclitaxel-resistant non-small-cell lung cancer cells is not clear. In this study, we investigated the effect of Curcumin on the Paclitaxel-resistant non-small-cell lung cancer cells and found that Curcumin treatment markedly increased the sensitivity of Paclitaxel-resistant non-small-cell lung cancer cells to Paclitaxel. Mechanically, the study revealed that Curcumin could reduce the expression of metastasis-associated gene 1 (MTA1) gene through upregulation of microRNA-30c in Paclitaxel-resistant non-small-cell lung cancer cells. During the course, MTA1 reduction sensitized Paclitaxel-resistant non-small-cell lung cancer cells and enhanced the effect of Paclitaxel. Taken together, our studies indicate that Curcumin increases the sensitivity of Paclitaxel-resistant non-small-cell lung cancer cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction. Curcumin might be a potential adjuvant for non-small-cell lung cancer patients during Paclitaxel treatment.

Protecting Privacy and Confidentiality in Environmental Health Research.

PubMed

Resnik, David B

2010-01-01

Environmental health researchers often need to make difficult decisions on how to protect privacy and confidentiality when they conduct research in the home or workplace. These dilemmas are different from those normally encountered in clinical research. Although protecting privacy and confidentiality is one of the most important principles of research involving human subjects, it can be overridden to prevent imminent harm to individuals or if required by law. Investigators should carefully consider the facts and circumstances and use good judgment when deciding whether to breach privacy or confidentiality.

47 CFR 76.9 - Confidentiality of proprietary information.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 4 2012-10-01 2012-10-01 false Confidentiality of proprietary information. 76.9 Section 76.9 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE General § 76.9 Confidentiality of proprietary...

47 CFR 76.9 - Confidentiality of proprietary information.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 4 2013-10-01 2013-10-01 false Confidentiality of proprietary information. 76.9 Section 76.9 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE General § 76.9 Confidentiality of proprietary...

47 CFR 76.9 - Confidentiality of proprietary information.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 4 2010-10-01 2010-10-01 false Confidentiality of proprietary information. 76.9 Section 76.9 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE General § 76.9 Confidentiality of proprietary...

47 CFR 76.9 - Confidentiality of proprietary information.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 4 2014-10-01 2014-10-01 false Confidentiality of proprietary information. 76.9 Section 76.9 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE General § 76.9 Confidentiality of proprietary...

47 CFR 76.9 - Confidentiality of proprietary information.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 4 2011-10-01 2011-10-01 false Confidentiality of proprietary information. 76.9 Section 76.9 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE General § 76.9 Confidentiality of proprietary...

21 CFR 1316.23 - Confidentiality of identity of research subjects.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Confidentiality of identity of research subjects... Confidentiality of identity of research subjects. (a) Any person conducting a bona fide research project directly.... 1242; 21 U.S.C. 801) who intends to maintain the confidentiality of the identity of those persons who...

21 CFR 1316.23 - Confidentiality of identity of research subjects.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 9 2014-04-01 2014-04-01 false Confidentiality of identity of research subjects... Confidentiality of identity of research subjects. (a) Any person conducting a bona fide research project directly.... 1242; 21 U.S.C. 801) who intends to maintain the confidentiality of the identity of those persons who...

21 CFR 1316.23 - Confidentiality of identity of research subjects.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Confidentiality of identity of research subjects... Confidentiality of identity of research subjects. (a) Any person conducting a bona fide research project directly.... 1242; 21 U.S.C. 801) who intends to maintain the confidentiality of the identity of those persons who...

21 CFR 1316.23 - Confidentiality of identity of research subjects.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Confidentiality of identity of research subjects... Confidentiality of identity of research subjects. (a) Any person conducting a bona fide research project directly.... 1242; 21 U.S.C. 801) who intends to maintain the confidentiality of the identity of those persons who...

21 CFR 1316.23 - Confidentiality of identity of research subjects.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 9 2013-04-01 2013-04-01 false Confidentiality of identity of research subjects... Confidentiality of identity of research subjects. (a) Any person conducting a bona fide research project directly.... 1242; 21 U.S.C. 801) who intends to maintain the confidentiality of the identity of those persons who...

Physician Knowledge and Attitudes around Confidential Care for Minor Patients.

PubMed

Riley, Margaret; Ahmed, Sana; Reed, Barbara D; Quint, Elisabeth H

2015-08-01

Minor adolescent patients have a legal right to access certain medical services confidentially without parental consent or notification. We sought to assess physicians' knowledge of these laws, attitudes around the provision of confidential care to minors, and barriers to providing confidential care. An anonymous online survey was sent to physicians in the Departments of Family Medicine, Internal Medicine-Pediatrics, Obstetrics/Gynecology, and Pediatrics at the University of Michigan. Response rate was 40% (259/650). The majority of physicians felt comfortable addressing sexual health, mental health, and substance use with adolescent patients. On average, physicians answered just over half of the legal knowledge questions correctly (mean 56.6% ± 16.7%). The majority of physicians approved of laws allowing minors to consent for confidential care (90.8% ± 1.7% approval), while substantially fewer (45.1% ± 4.5%) approved of laws allowing parental notification of this care at the physician's discretion. Most physicians agreed that assured access to confidential care should be a right for adolescents. After taking the survey most physicians (76.6%) felt they needed additional training on confidentiality laws. The provision of confidential care to minors was perceived to be most inhibited by insurance issues, parental concerns/relationships with the family, and issues with the electronic medical record. Physicians are comfortable discussing sensitive issues with adolescents and generally approve of minor consent laws, but lack knowledge about what services a minor can access confidentially. Further research is needed to assess best methods to educate physicians about minors' legal rights to confidential healthcare services. Copyright © 2015 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

Breaching confidentiality: medical mandatory reporting laws in Iran

PubMed Central

Milanifar, Alireza; Larijani, Bagher; Paykarzadeh, Parvaneh; Ashtari, Golanna; Mehdi Akhondi, Mohammad

2014-01-01

Medical ethics is a realm where four important subjects of philosophy, medicine, theology and law are covered. Physicians and philosophers cooperation in this area will have great efficiency in the respective ethical rules formation. In addition to respect the autonomy of the patient, physician’s obligation is to ensure that the medical intervention has benefit for the patient and the harm is minimal. There is an obvious conflict between duty of confidentiality and duty of mandatory reporting. Professional confidentiality is one of the basic components in building a constant physician-patient relationship which nowadays, beside the novelty, it is the subject of discussion. Legal obligation of confidentiality is not absolute. In physician-patient relationship, keeping patient’s secrets and maintaining confidentiality is a legal and ethical duty, and disclosure of such secrets is mainly through specific statutes. Thus, there are a number of situations where breach of confidentiality is permitted in different legal systems. One of the situations where breaching confidentiality is permitted is the medical mandatory reporting to the relevant authority which is in accordance with many countries’ legal systems. Some situations are considered in many countries legal systems’ such as notification of births and deaths, infectious diseases, child abuse, sport and relevant events, medical errors, drug side effects and dangerous pregnancies. In this paper, we will examine and discuss medical mandatory reporting and its ethical and legal aspects in the judicial and legal system of Iran and few other countries. Finally we will suggest making Medical Mandatory Reporting Law in Iran. PMID:25512832

Breaching confidentiality: medical mandatory reporting laws in Iran.

PubMed

Milanifar, Alireza; Larijani, Bagher; Paykarzadeh, Parvaneh; Ashtari, Golanna; Mehdi Akhondi, Mohammad

2014-01-01

Medical ethics is a realm where four important subjects of philosophy, medicine, theology and law are covered. Physicians and philosophers cooperation in this area will have great efficiency in the respective ethical rules formation. In addition to respect the autonomy of the patient, physician's obligation is to ensure that the medical intervention has benefit for the patient and the harm is minimal. There is an obvious conflict between duty of confidentiality and duty of mandatory reporting. Professional confidentiality is one of the basic components in building a constant physician-patient relationship which nowadays, beside the novelty, it is the subject of discussion. Legal obligation of confidentiality is not absolute. In physician-patient relationship, keeping patient's secrets and maintaining confidentiality is a legal and ethical duty, and disclosure of such secrets is mainly through specific statutes. Thus, there are a number of situations where breach of confidentiality is permitted in different legal systems. One of the situations where breaching confidentiality is permitted is the medical mandatory reporting to the relevant authority which is in accordance with many countries' legal systems. Some situations are considered in many countries legal systems' such as notification of births and deaths, infectious diseases, child abuse, sport and relevant events, medical errors, drug side effects and dangerous pregnancies. In this paper, we will examine and discuss medical mandatory reporting and its ethical and legal aspects in the judicial and legal system of Iran and few other countries. Finally we will suggest making Medical Mandatory Reporting Law in Iran.

49 CFR 40.351 - What confidentiality requirements apply to service agents?

Code of Federal Regulations, 2013 CFR

2013-10-01

... confidentiality and security measures to ensure that confidential employee records are not available to unauthorized persons. This includes protecting the physical security of records, access controls, and computer security measures to safeguard confidential data in electronic data bases. ...

49 CFR 40.351 - What confidentiality requirements apply to service agents?

Code of Federal Regulations, 2014 CFR

2014-10-01

... confidentiality and security measures to ensure that confidential employee records are not available to unauthorized persons. This includes protecting the physical security of records, access controls, and computer security measures to safeguard confidential data in electronic data bases. ...

49 CFR 40.351 - What confidentiality requirements apply to service agents?

Code of Federal Regulations, 2012 CFR

2012-10-01

... confidentiality and security measures to ensure that confidential employee records are not available to unauthorized persons. This includes protecting the physical security of records, access controls, and computer security measures to safeguard confidential data in electronic data bases. ...

49 CFR 40.351 - What confidentiality requirements apply to service agents?

Code of Federal Regulations, 2011 CFR

2011-10-01

... confidentiality and security measures to ensure that confidential employee records are not available to unauthorized persons. This includes protecting the physical security of records, access controls, and computer security measures to safeguard confidential data in electronic data bases. ...

In vitro biocompatibility, inflammatory response, and osteogenic potential of 4 root canal sealers: Sealapex, Sankin apatite root sealer, MTA Fillapex, and iRoot SP root canal sealer.

PubMed

Chang, Seok-Woo; Lee, So-Youn; Kang, Soo-Kyung; Kum, Kee-Yeon; Kim, Eun-Cheol

2014-10-01

The objective of this study was to compare the cytotoxicity, inflammatory response, osteogenic effect, and the signaling mechanism of these biologic activities of 4 calcium compound-based root canal sealers (ie, Sealapex [Sybron Kerr, WA], apatite root sealer [ARS; Dentsply Sankin, Tokyo, Japan], MTA Fillapex [Angelus Indústria de Produtos Odontológicos S/A, Londrina, PR, Brazil], and iRoot SP [Innovative BioCreamix Inc, Vancouver, Canada]) in human periodontal ligament cells. Cytotoxicity was assessed using the 3-(4,5-dimethylthiazolyl-2-yl)-2,5-diphenyltetrazolium bromide assay. Levels of inflammatory mediators were measured by enzyme-linked immunosorbent assay, reverse-transcription polymerase chain reaction, and Western blot analysis. Osteogenic potential was evaluated by alkaline phosphatase activity, alizarin red staining, and marker genes by reverse-transcription polymerase chain reaction. The signal transduction pathways were examined by Western blotting. None of the sealers were cytotoxic. ARS, MTA Fillapex, and iRoot SP induced a lower expression of proinflammatory mediators than Sealapex. All sealers increased ALP activity and the formation of mineralized nodules and up-regulated the expression of osteoblastic marker messenger RNA. ARS, MTA Fillapex, and iRoot SP showed superior osteogenic potential compared with Sealapex. The expression and/or activation of integrin receptors and downstream signaling molecules, including focal adhesion kinase, paxillin, Akt, mitogen-activated protein kinase, and nuclear factor κB, was induced by ARS, MTA Fillapex, and iRoot SP treatment but not by Sealapex treatment. We show for the first time that ARS, MTA Fillapex, and iRoot SP induce a lower expression of inflammatory mediators and enhance osteoblastic differentiation of PDLCs via the integrin-mediated signaling pathway compared with Sealapex. Copyright © 2014 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

47 CFR 8.16 - Confidentiality of proprietary information.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 1 2013-10-01 2013-10-01 false Confidentiality of proprietary information. 8.16 Section 8.16 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRESERVING THE OPEN INTERNET § 8.16 Confidentiality of proprietary information. (a) Any materials filed in the course of a...

47 CFR 8.16 - Confidentiality of proprietary information.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 1 2014-10-01 2014-10-01 false Confidentiality of proprietary information. 8.16 Section 8.16 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRESERVING THE OPEN INTERNET § 8.16 Confidentiality of proprietary information. (a) Any materials filed in the course of a...

47 CFR 8.16 - Confidentiality of proprietary information.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 1 2012-10-01 2012-10-01 false Confidentiality of proprietary information. 8.16 Section 8.16 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRESERVING THE OPEN INTERNET § 8.16 Confidentiality of proprietary information. (a) Any materials filed in the course of a...

40 CFR 763.179 - Confidential business information claims.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Confidential business information... business information claims. (a) Applicants for exemptions under § 763.173 may assert a Confidential Business Information (CBI) claim for information in an exemption application or supplement submitted to the...

Confidentiality: From the Stacks to the Witness Stand.

ERIC Educational Resources Information Center

Lee, Janis M.; Smith, G. Guy

1988-01-01

A library director describes her experience of safeguarding the confidentiality of the circulation records of a woman who went on a shooting rampage at a shopping mall. The lawyer who represented the library discusses the legal responsibility of public and school libraries concerning confidentiality. (CLB)

40 CFR 763.179 - Confidential business information claims.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Confidential business information... business information claims. (a) Applicants for exemptions under § 763.173 may assert a Confidential Business Information (CBI) claim for information in an exemption application or supplement submitted to the...

40 CFR 303.31 - Assurance of claimant confidentiality.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 29 2013-07-01 2013-07-01 false Assurance of claimant confidentiality. 303.31 Section 303.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND... VIOLATIONS UNDER SUPERFUND Criteria for Payment of Award § 303.31 Assurance of claimant confidentiality. No...

40 CFR 303.31 - Assurance of claimant confidentiality.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 28 2014-07-01 2014-07-01 false Assurance of claimant confidentiality. 303.31 Section 303.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND... VIOLATIONS UNDER SUPERFUND Criteria for Payment of Award § 303.31 Assurance of claimant confidentiality. No...

40 CFR 303.31 - Assurance of claimant confidentiality.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 29 2012-07-01 2012-07-01 false Assurance of claimant confidentiality. 303.31 Section 303.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND... VIOLATIONS UNDER SUPERFUND Criteria for Payment of Award § 303.31 Assurance of claimant confidentiality. No...

40 CFR 303.31 - Assurance of claimant confidentiality.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 28 2011-07-01 2011-07-01 false Assurance of claimant confidentiality. 303.31 Section 303.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND... VIOLATIONS UNDER SUPERFUND Criteria for Payment of Award § 303.31 Assurance of claimant confidentiality. No...

47 CFR 8.16 - Confidentiality of proprietary information.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 1 2011-10-01 2011-10-01 false Confidentiality of proprietary information. 8.16 Section 8.16 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRESERVING THE OPEN INTERNET § 8.16 Confidentiality of proprietary information. (a) Any materials filed in the course of a...

19 CFR 103.35 - Confidential commercial information; exempt.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Confidential commercial information; exempt. 103....35 Confidential commercial information; exempt. (a) In general. For purposes of this section, “commercial information” is defined as trade secret, commercial, or financial information obtained from a...

21 CFR 809.4 - Confidentiality of submitted information.

Code of Federal Regulations, 2011 CFR

2011-04-01

... (CONTINUED) MEDICAL DEVICES IN VITRO DIAGNOSTIC PRODUCTS FOR HUMAN USE General Provisions § 809.4... within the exemption established in § 20.61 of this chapter shall be treated as confidential by the Food... Drug Administration will determine whether information submitted will be treated as confidential in...

21 CFR 809.4 - Confidentiality of submitted information.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (CONTINUED) MEDICAL DEVICES IN VITRO DIAGNOSTIC PRODUCTS FOR HUMAN USE General Provisions § 809.4... within the exemption established in § 20.61 of this chapter shall be treated as confidential by the Food... Drug Administration will determine whether information submitted will be treated as confidential in...

15 CFR 325.16 - Protecting confidentiality of information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Protecting confidentiality of information. 325.16 Section 325.16 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign... EXPORT TRADE CERTIFICATES OF REVIEW § 325.16 Protecting confidentiality of information. (a) Any...

15 CFR 325.16 - Protecting confidentiality of information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Protecting confidentiality of information. 325.16 Section 325.16 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign... EXPORT TRADE CERTIFICATES OF REVIEW § 325.16 Protecting confidentiality of information. (a) Any...

15 CFR 325.16 - Protecting confidentiality of information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Protecting confidentiality of information. 325.16 Section 325.16 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign... EXPORT TRADE CERTIFICATES OF REVIEW § 325.16 Protecting confidentiality of information. (a) Any...

15 CFR 325.16 - Protecting confidentiality of information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Protecting confidentiality of information. 325.16 Section 325.16 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign... EXPORT TRADE CERTIFICATES OF REVIEW § 325.16 Protecting confidentiality of information. (a) Any...

Practical State Machine Replication with Confidentiality

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duan, Sisi; Zhang, Haibin

2016-01-01

We study how to enable arbitrary randomized algorithms in Byzantine fault-tolerant (BFT) settings. We formalize a randomized BFT protocol and provide a simple and efficient construction that can be built on any existing BFT protocols while adding practically no overhead. We go one step further to revisit a confidential BFT protocol (Yin et al., SOSP '03). We show that their scheme is potentially susceptible to safety and confidentiality attacks. We then present a new protocol that is secure in the stronger model we formalize, by extending the idea of a randomized BFT protocol. Our protocol uses only efficient symmetric cryptography,more » while Yin et al.'s uses costly threshold signatures. We implemented and evaluated our protocols on microbenchmarks and real-world use cases. We show that our randomized BFT protocol is as efficient as conventional BFT protocols, and our confidential BFT protocol is two to three orders of magnitude faster than Yin et al.'s, which is less secure than ours.« less

Delinquent Behavior and Emerging Substance Use in the MTA at 36 Months: Prevalence, Course, and Treatment Effects

ERIC Educational Resources Information Center

Molina, Brooke S. G.; Flory, Kate; Hinshaw, Stephen P.; Greiner, Andrew R.; Arnold, L. Eugene; Swanson, James M.; Hechtman, Lily; Jensen, Peter S.; Vitiello, Benedetto; Hoza, Betsy; Pelham, William E.; Elliott, Glen R.; Wells, Karen C.; Abikoff, Howard B.; Gibbons, Robert D.; Marcus, Sue; Conners, C. Keith; Epstein, Jeffery N.; Greenhill, Laurence L.; March, John S.; Newcorn, Jeffrey H.; Severe, Joanne B.; Wigal, Timothy

2007-01-01

Objective: To compare delinquent behavior and early substance use between the children in the Multimodal Treatment Study of Children With ADHD (MTA; N = 487) and those in a local normative comparison group (n = 272) at 24 and 36 months postrandomization and to test whether these outcomes were predicted by the randomly assigned treatments and…

75 FR 75586 - Confidentiality of Suspicious Activity Reports

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-03

...] RIN 1550-AC26 Confidentiality of Suspicious Activity Reports AGENCY: The Office of Thrift Supervision... implementing the Bank Secrecy Act (BSA) governing the confidentiality of a suspicious activity report (SAR) to... corporations regulated by the OTS, to keep certain records and make certain reports that have been determined...

10 CFR 207.4 - Confidentiality of energy information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false Confidentiality of energy information. 207.4 Section 207.4 Energy DEPARTMENT OF ENERGY OIL COLLECTION OF INFORMATION Collection of Information Under the Energy Supply and Environmental Coordination Act of 1974 § 207.4 Confidentiality of energy information. (a...

10 CFR 207.4 - Confidentiality of energy information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false Confidentiality of energy information. 207.4 Section 207.4 Energy DEPARTMENT OF ENERGY OIL COLLECTION OF INFORMATION Collection of Information Under the Energy Supply and Environmental Coordination Act of 1974 § 207.4 Confidentiality of energy information. (a...

10 CFR 207.4 - Confidentiality of energy information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false Confidentiality of energy information. 207.4 Section 207.4 Energy DEPARTMENT OF ENERGY OIL COLLECTION OF INFORMATION Collection of Information Under the Energy Supply and Environmental Coordination Act of 1974 § 207.4 Confidentiality of energy information. (a...

10 CFR 207.4 - Confidentiality of energy information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Confidentiality of energy information. 207.4 Section 207.4 Energy DEPARTMENT OF ENERGY OIL COLLECTION OF INFORMATION Collection of Information Under the Energy Supply and Environmental Coordination Act of 1974 § 207.4 Confidentiality of energy information. (a...

10 CFR 207.4 - Confidentiality of energy information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false Confidentiality of energy information. 207.4 Section 207.4 Energy DEPARTMENT OF ENERGY OIL COLLECTION OF INFORMATION Collection of Information Under the Energy Supply and Environmental Coordination Act of 1974 § 207.4 Confidentiality of energy information. (a...

29 CFR 4003.8 - Request for confidential treatment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Request for confidential treatment. 4003.8 Section 4003.8 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION GENERAL RULES FOR ADMINISTRATIVE REVIEW OF AGENCY DECISIONS General Provisions § 4003.8 Request for confidential treatment. If any...

40 CFR 85.2123 - Treatment of confidential information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Treatment of confidential information... Warranty Regulations and Voluntary Aftermarket Part Certification Program § 85.2123 Treatment of... pursuant to this subpart is entitled to confidential treatment as provided by 40 CFR part 2, subpart B. (b...

42 CFR 2.22 - Notice to patients of Federal confidentiality requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS General Provisions § 2.22... alcohol and drug abuse patient records. (d) Sample notice. Confidentiality of Alcohol and Drug Abuse Patient Records The confidentiality of alcohol and drug abuse patient records maintained by this program...

42 CFR 2.22 - Notice to patients of Federal confidentiality requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS General Provisions § 2.22... alcohol and drug abuse patient records. (d) Sample notice. Confidentiality of Alcohol and Drug Abuse Patient Records The confidentiality of alcohol and drug abuse patient records maintained by this program...

42 CFR 2.22 - Notice to patients of Federal confidentiality requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS General Provisions § 2.22... alcohol and drug abuse patient records. (d) Sample notice. Confidentiality of Alcohol and Drug Abuse Patient Records The confidentiality of alcohol and drug abuse patient records maintained by this program...

42 CFR 2.22 - Notice to patients of Federal confidentiality requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS General Provisions § 2.22... alcohol and drug abuse patient records. (d) Sample notice. Confidentiality of Alcohol and Drug Abuse Patient Records The confidentiality of alcohol and drug abuse patient records maintained by this program...

42 CFR 2.22 - Notice to patients of Federal confidentiality requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS General Provisions § 2.22... alcohol and drug abuse patient records. (d) Sample notice. Confidentiality of Alcohol and Drug Abuse Patient Records The confidentiality of alcohol and drug abuse patient records maintained by this program...

38 CFR 1.520 - Confidentiality of social data.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Confidentiality of social... Confidentiality of social data. Persons having access to social data will be conscious of the fact that the family..., and the social worker, or may destroy their mutual confidence and influence, rendering it impossible...

Confidentiality of Children's Records. Education Memo No. 1.

ERIC Educational Resources Information Center

Russell, Pam

This memo describes provisions in state and federal law relating to confidentiality and disclosure of children's records kept by law enforcement officers, courts, and schools. It does not discuss confidentiality of children's medical records or child abuse reports. These provisions are discussed: (1) law enforcement and court records of children…

38 CFR 1.520 - Confidentiality of social data.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Confidentiality of social... Confidentiality of social data. Persons having access to social data will be conscious of the fact that the family..., and the social worker, or may destroy their mutual confidence and influence, rendering it impossible...

38 CFR 1.520 - Confidentiality of social data.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Confidentiality of social... Confidentiality of social data. Persons having access to social data will be conscious of the fact that the family..., and the social worker, or may destroy their mutual confidence and influence, rendering it impossible...

38 CFR 1.520 - Confidentiality of social data.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Confidentiality of social... Confidentiality of social data. Persons having access to social data will be conscious of the fact that the family..., and the social worker, or may destroy their mutual confidence and influence, rendering it impossible...

38 CFR 1.520 - Confidentiality of social data.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Confidentiality of social... Confidentiality of social data. Persons having access to social data will be conscious of the fact that the family..., and the social worker, or may destroy their mutual confidence and influence, rendering it impossible...

40 CFR 53.15 - Trade secrets and confidential or privileged information.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 6 2013-07-01 2013-07-01 false Trade secrets and confidential or... Provisions § 53.15 Trade secrets and confidential or privileged information. Any information submitted under this part that is claimed to be a trade secret or confidential or privileged information shall be...

40 CFR 53.15 - Trade secrets and confidential or privileged information.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 6 2012-07-01 2012-07-01 false Trade secrets and confidential or... Provisions § 53.15 Trade secrets and confidential or privileged information. Any information submitted under this part that is claimed to be a trade secret or confidential or privileged information shall be...

40 CFR 53.15 - Trade secrets and confidential or privileged information.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 5 2011-07-01 2011-07-01 false Trade secrets and confidential or... Provisions § 53.15 Trade secrets and confidential or privileged information. Any information submitted under this part that is claimed to be a trade secret or confidential or privileged information shall be...

40 CFR 53.15 - Trade secrets and confidential or privileged information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 6 2014-07-01 2014-07-01 false Trade secrets and confidential or... Provisions § 53.15 Trade secrets and confidential or privileged information. Any information submitted under this part that is claimed to be a trade secret or confidential or privileged information shall be...

40 CFR 53.15 - Trade secrets and confidential or privileged information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Trade secrets and confidential or... Provisions § 53.15 Trade secrets and confidential or privileged information. Any information submitted under this part that is claimed to be a trade secret or confidential or privileged information shall be...

Disaster easily averted? Data confidentiality and the hospital desktop computer.

PubMed

Sethi, Neeraj; Lane, Gethin; Newton, Sophie; Egan, Philip; Ghosh, Samit

2014-05-01

We specifically identified the hospital desktop computer as a potential source of breaches in confidentiality. We aimed to evaluate if there was accessible, unprotected, confidential information stored on the desktop screen on computers in a district general hospital and if so, how a teaching intervention could improve this situation. An unannounced spot check of 59 ward computers was performed. Data were collected regarding how many had confidential information stored on the desktop screen without any password protection. An online learning module was mandated for healthcare staff and a second cycle of inspection performed. A district general hospital. Two doctors conducted the audit. Computers in clinical areas were assessed. All clinical staff with computer access underwent the online learning module. An online learning module regarding data protection and confidentiality. In the first cycle, 55% of ward computers had easily accessible patient or staff confidential information stored on their desktop screen. This included handovers, referral letters, staff sick leave lists, audits and nursing reports. The majority (85%) of computers accessed were logged in under a generic username and password. The intervention produced an improvement in the second cycle findings with only 26% of computers being found to have unprotected confidential information stored on them. The failure to comply with appropriate confidential data protection regulations is a persistent problem. Education produces some improvement but we also propose a systemic approach to solving this problem. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Treatment of horizontal root fractures using MTA as apical plug: report of 3 cases.

PubMed

Kusgoz, Adem; Yildirim, Tahsin; Tanriver, Mehmet; Yesilyurt, Cemal

2009-05-01

Root fractures are rare occurrences through all dental injuries. They comprise only 0.5% to 7.0% of traumas affecting the permanent teeth. Generally the cervical and middle thirds of the roots are affected. The healing of these lesions depends on the health of the pulp, dentine, cementum, and alveolar bone. These case reports describe the management and 2-year follow-up of 3 maxillary central incisors with horizontal root fractures treated with mineral trioxide aggregate (MTA) as apical plug.

Using Working Agreements in Participatory Action Research: Working through Moral Problems with Malaysian Students

ERIC Educational Resources Information Center

Balakrishnan, Vishalache; Cornforth, Sue

2013-01-01

In this paper we propose that taking time before the work begins to develop agreements about how to work together in participatory action research enables researchers to directly address several ethical issues that can be problematic in this type of research: gaining fully informed consent; in-group confidentiality; cultural misconceptions; and…

[Professional confidentiality and the family].

PubMed

Louvrier, P

2006-09-01

The roots of " doctor-patient privilege " or professional confidentiality go back to the Greek island of Cos - Hippocrates' birthplace. The Cos school advocated silence about what the doctor might learn during his visits. In 1868 the Napoleonic Criminal Code sanctioned those who divulged secrets that were entrusted to them by virtue of their profession or estate. The [Belgian medical association's] Code of Professional Ethics extends the bounds of professional confidentiality to include everything that the doctor sees, has knowledge of, learns of, ascertains, discovers, or surprises. Confidentiality as a matter of public policy is relative. It is a tool for the preservation of values, allowing access to health care without fear of divulgation. This leads to possible conflicts of values, conflicts between two duties involving a value that can be protected only to the detriment of another value. The family's rights are specified in Belgium's law on patient's rights, to wit: indirect consultation of the medical file after an individual's death and representation of a patient who is not able to exercise her/his rights her/himself. Silence is nevertheless the rule. The care that an illness calls for generally forces the doctor to make certain disclosures to the patient's family about the state of the illness. This usually goes no farther if the ailment is benign. However, in some sensitive situations (HIV, alcoholism, and divorce), the doctor must bear in mind that the patient may oppose the disclosure of any and all information. A good understanding of the foundations of professional confidentiality, informing the patient, and the doctor's own human qualities should make it possible to get hitherto stalled situations to move forward. The patient remains the doctor's primary focus.

The MTA UXO Survey and Target Recovery on Lake Erie at the Former Erie Army Depot

DTIC Science & Technology

2009-12-01

MTA Demonstration Front Matter ii FIGURES 1. Firing fans and target locations for Erie Army Depot in 1965...triangles at the base of the image show the locations of the 15 fixed firing positions that were used for proof firing projectiles...the marshland adjacent to the firing ranges, and along beaches fronting the former Depot, (Reference 2, Appendices B and J).3-5 The impact areas

Genetic secrets: Protecting privacy and confidentiality in the genetic era

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rothstein, M.A.

1998-07-01

Few developments are likely to affect human beings more profoundly in the long run than the discoveries resulting from advances in modern genetics. Although the developments in genetic technology promise to provide many additional benefits, their application to genetic screening poses ethical, social, and legal questions, many of which are rooted in issues of privacy and confidentiality. The ethical, practical, and legal ramifications of these and related questions are explored in depth. The broad range of topics includes: the privacy and confidentiality of genetic information; the challenges to privacy and confidentiality that may be projected to result from the emergingmore » genetic technologies; the role of informed consent in protecting the confidentiality of genetic information in the clinical setting; the potential uses of genetic information by third parties; the implications of changes in the health care delivery system for privacy and confidentiality; relevant national and international developments in public policies, professional standards, and laws; recommendations; and the identification of research needs.« less

40 CFR 704.7 - Confidential business information claims.

Code of Federal Regulations, 2012 CFR

2012-07-01

... notice at the time it is submitted to EPA, the notice will be placed in an open file available to the public without further notice to the respondent. (c) To assert a claim of confidentiality for data... be complete. In that copy the respondent must indicate what data, if any, are claimed as confidential...

15 CFR 718.2 - Identification of confidential business information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... business information. 718.2 Section 718.2 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS CONFIDENTIAL BUSINESS INFORMATION 718.2 Identification of confidential business...

42 CFR 493.1231 - Standard: Confidentiality of patient information.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Standard: Confidentiality of patient information... AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing General Laboratory Systems § 493.1231 Standard: Confidentiality of patient information...

42 CFR 493.1231 - Standard: Confidentiality of patient information.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 5 2012-10-01 2012-10-01 false Standard: Confidentiality of patient information... AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing General Laboratory Systems § 493.1231 Standard: Confidentiality of patient information...

42 CFR 493.1231 - Standard: Confidentiality of patient information.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 5 2014-10-01 2014-10-01 false Standard: Confidentiality of patient information... AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing General Laboratory Systems § 493.1231 Standard: Confidentiality of patient information...

42 CFR 493.1231 - Standard: Confidentiality of patient information.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 5 2013-10-01 2013-10-01 false Standard: Confidentiality of patient information... AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing General Laboratory Systems § 493.1231 Standard: Confidentiality of patient information...

7 CFR 1425.5 - Confidentiality.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS COOPERATIVE MARKETING ASSOCIATIONS § 1425.5 Confidentiality. Information submitted to CCC related to trade secrets, financial or commercial operations, or the financial...

Treatment of Children With Attention-Deficit/Hyperactivity Disorder (ADHD) and Irritability: Results From the Multimodal Treatment Study of Children With ADHD (MTA)

PubMed Central

Fernández de la Cruz, Lorena; Simonoff, Emily; McGough, James J.; Halperin, Jeffrey M.; Arnold, L. Eugene; Stringaris, Argyris

2015-01-01

Objective Clinically impairing irritability affects 25% to 45% of children with attention-deficit/hyperactivity disorder (ADHD); yet, we know little about what interventions are effective in treating children with ADHD and co-occurring irritability. We used data from the Multimodal Treatment Study of Children With ADHD (MTA) to address 3 aims: to establish whether irritability in children with ADHD can be distinguished from other symptoms of oppositional defiant disorder (ODD); to examine whether ADHD treatment is effective in treating irritability; and to examine how irritability influences ADHD treatment outcomes. Method Secondary analyses of data from the MTA included multivariate analyses, and intent-to-treat random-effects regression models were used. Results Irritability was separable from other ODD symptoms. For treating irritability, systematic stimulant treatment was superior to behavioral management but not to routine community care; a combination of stimulants and behavioral treatment was superior to community care and to behavioral treatment alone, but not to medication alone. Irritability did not moderate the impact of treatment on parent- and teacher-reported ADHD symptoms in any of the 4 treatment groups. Conclusion Treatments targeting ADHD symptoms are helpful for improving irritability in children with ADHD. Moreover, irritability does not appear to influence the response to treatment of ADHD. Clinical trial registration information Multimodal Treatment Study of Children With Attention Deficit and Hyperactivity Disorder (MTA); http://www.clinicaltrials.gov; NCT00000388. PMID:25524791

50 CFR 600.130 - Protection of confidentiality of statistics.

Code of Federal Regulations, 2011 CFR

2011-10-01

... statistics. 600.130 Section 600.130 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... Fishery Management Councils § 600.130 Protection of confidentiality of statistics. Each Council must establish appropriate procedures for ensuring the confidentiality of the statistics that may be submitted to...

22 CFR 1104.17 - Confidentiality of archaeological resource information.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Confidentiality of archaeological resource information. 1104.17 Section 1104.17 Foreign Relations INTERNATIONAL BOUNDARY AND WATER COMMISSION, UNITED STATES AND MEXICO, UNITED STATES SECTION PROTECTION OF ARCHAEOLOGICAL RESOURCES § 1104.17 Confidentiality...

20 CFR 404.2122 - Confidentiality of information and records.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Confidentiality of information and records. 404.2122 Section 404.2122 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE... comply with the provisions for confidentiality of information, including the security of systems, and...

20 CFR 416.2222 - Confidentiality of information and records.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Confidentiality of information and records. 416.2222 Section 416.2222 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY... comply with the provisions for confidentiality of information, including the security of systems, and...

22 CFR 1104.17 - Confidentiality of archaeological resource information.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Confidentiality of archaeological resource information. 1104.17 Section 1104.17 Foreign Relations INTERNATIONAL BOUNDARY AND WATER COMMISSION, UNITED STATES AND MEXICO, UNITED STATES SECTION PROTECTION OF ARCHAEOLOGICAL RESOURCES § 1104.17 Confidentiality...

20 CFR 702.508 - Vocational rehabilitation; confidentiality of information.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Vocational rehabilitation; confidentiality of... PROCEDURE Vocational Rehabilitation § 702.508 Vocational rehabilitation; confidentiality of information. The... which it is provided; (b) Interested persons and agencies have been advised that any information...

50 CFR 600.130 - Protection of confidentiality of statistics.

Code of Federal Regulations, 2010 CFR

2010-10-01

... statistics. 600.130 Section 600.130 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL... Fishery Management Councils § 600.130 Protection of confidentiality of statistics. Each Council must establish appropriate procedures for ensuring the confidentiality of the statistics that may be submitted to...

Effects of LED phototherapy on bone defects grafted with MTA, bone morphogenetic proteins and guided bone regeneration: a Raman spectroscopic study.

PubMed

Pinheiro, Antonio L B; Soares, Luiz G P; Cangussú, Maria Cristina T; Santos, Nicole R S; Barbosa, Artur Felipe S; Silveira Júnior, Landulfo

2012-09-01

We studied peaks of calcium hydroxyapatite (CHA) and protein and lipid CH groups in defects grafted with mineral trioxide aggregate (MTA) treated or not with LED irradiation, bone morphogenetic proteins and guided bone regeneration. A total of 90 rats were divided into ten groups each of which was subdivided into three subgroups (evaluated at 15, 21 and 30 days after surgery). Defects were irradiated with LED light (wavelength 850 ± 10 nm) at 48-h intervals for 15 days. Raman readings were taken at the surface of the defects. There were no statistically significant differences in the CHA peaks among the nonirradiated defects at any of the experimental time-points. On the other hand, there were significant differences between the defects filled with blood clot and the irradiated defects at all time-points (p < 0.001, p = 0.02, p < 0.001). There were significant differences between the mean peak CHA in nonirradiated defects at all the experimental time-points (p < 0.01). The mean peak of the defects filled with blood clot was significantly different from that of the defects filled with MTA (p < 0.001). There were significant differences between the defects filled with blood clot and the irradiated defects (p < 0.001). The results of this study using Raman spectral analysis indicate that infrared LED light irradiation improves the deposition of CHA in healing bone grafted or not with MTA.

42 CFR 493.1231 - Standard: Confidentiality of patient information.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Confidentiality of patient information. 493.1231 Section 493.1231 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH... Nonwaived Testing General Laboratory Systems § 493.1231 Standard: Confidentiality of patient information...

18 CFR 1312.18 - Confidentiality of archaeological resource information.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Confidentiality of archaeological resource information. 1312.18 Section 1312.18 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY PROTECTION OF ARCHAEOLOGICAL RESOURCES: UNIFORM REGULATIONS § 1312.18 Confidentiality of...

18 CFR 1312.18 - Confidentiality of archaeological resource information.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Confidentiality of archaeological resource information. 1312.18 Section 1312.18 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY PROTECTION OF ARCHAEOLOGICAL RESOURCES: UNIFORM REGULATIONS § 1312.18 Confidentiality of...

18 CFR 1312.18 - Confidentiality of archaeological resource information.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Confidentiality of archaeological resource information. 1312.18 Section 1312.18 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY PROTECTION OF ARCHAEOLOGICAL RESOURCES: UNIFORM REGULATIONS § 1312.18 Confidentiality of...

18 CFR 1312.18 - Confidentiality of archaeological resource information.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Confidentiality of archaeological resource information. 1312.18 Section 1312.18 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY PROTECTION OF ARCHAEOLOGICAL RESOURCES: UNIFORM REGULATIONS § 1312.18 Confidentiality of...

18 CFR 1312.18 - Confidentiality of archaeological resource information.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Confidentiality of archaeological resource information. 1312.18 Section 1312.18 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY PROTECTION OF ARCHAEOLOGICAL RESOURCES: UNIFORM REGULATIONS § 1312.18 Confidentiality of...

7 CFR 1205.540 - Confidential books, records, and reports.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 10 2013-01-01 2013-01-01 false Confidential books, records, and reports. 1205.540 Section 1205.540 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL... Confidential books, records, and reports. All information obtained from the books, records, and reports of...

7 CFR 1205.540 - Confidential books, records, and reports.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 10 2012-01-01 2012-01-01 false Confidential books, records, and reports. 1205.540 Section 1205.540 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL... Confidential books, records, and reports. All information obtained from the books, records, and reports of...

7 CFR 1205.540 - Confidential books, records, and reports.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential books, records, and reports. 1205.540 Section 1205.540 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL... Confidential books, records, and reports. All information obtained from the books, records, and reports of...

7 CFR 1205.540 - Confidential books, records, and reports.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 10 2011-01-01 2011-01-01 false Confidential books, records, and reports. 1205.540 Section 1205.540 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL... Confidential books, records, and reports. All information obtained from the books, records, and reports of...

7 CFR 1205.540 - Confidential books, records, and reports.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 10 2014-01-01 2014-01-01 false Confidential books, records, and reports. 1205.540 Section 1205.540 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL... Confidential books, records, and reports. All information obtained from the books, records, and reports of...

Three-party authenticated key agreements for optimal communication

PubMed Central

Lee, Tian-Fu; Hwang, Tzonelih

2017-01-01

Authenticated key agreements enable users to determine session keys, and to securely communicate with others over an insecure channel via the session keys. This study investigates the lower bounds on communications for three-party authenticated key agreements and considers whether or not the sub-keys for generating a session key can be revealed in the channel. Since two clients do not share any common secret key, they require the help of the server to authenticate their identities and exchange confidential and authenticated information over insecure networks. However, if the session key security is based on asymmetric cryptosystems, then revealing the sub-keys cannot compromise the session key. The clients can directly exchange the sub-keys and reduce the transmissions. In addition, authenticated key agreements were developed by using the derived results of the lower bounds on communications. Compared with related approaches, the proposed protocols had fewer transmissions and realized the lower bounds on communications. PMID:28355253

Improving Individual Acceptance of Health Clouds through Confidentiality Assurance.

PubMed

Ermakova, Tatiana; Fabian, Benjamin; Zarnekow, Rüdiger

2016-10-26

Cloud computing promises to essentially improve healthcare delivery performance. However, shifting sensitive medical records to third-party cloud providers could create an adoption hurdle because of security and privacy concerns. This study examines the effect of confidentiality assurance in a cloud-computing environment on individuals' willingness to accept the infrastructure for inter-organizational sharing of medical data. We empirically investigate our research question by a survey with over 260 full responses. For the setting with a high confidentiality assurance, we base on a recent multi-cloud architecture which provides very high confidentiality assurance through a secret-sharing mechanism: Health information is cryptographically encoded and distributed in a way that no single and no small group of cloud providers is able to decode it. Our results indicate the importance of confidentiality assurance in individuals' acceptance of health clouds for sensitive medical data. Specifically, this finding holds for a variety of practically relevant circumstances, i.e., in the absence and despite the presence of conventional offline alternatives and along with pseudonymization. On the other hand, we do not find support for the effect of confidentiality assurance in individuals' acceptance of health clouds for non-sensitive medical data. These results could support the process of privacy engineering for health-cloud solutions.

Improving Individual Acceptance of Health Clouds through Confidentiality Assurance

PubMed Central

Fabian, Benjamin; Zarnekow, Rüdiger

2016-01-01

Summary Background Cloud computing promises to essentially improve healthcare delivery performance. However, shifting sensitive medical records to third-party cloud providers could create an adoption hurdle because of security and privacy concerns. Objectives This study examines the effect of confidentiality assurance in a cloud-computing environment on individuals’ willingness to accept the infrastructure for inter-organizational sharing of medical data. Methods We empirically investigate our research question by a survey with over 260 full responses. For the setting with a high confidentiality assurance, we base on a recent multi-cloud architecture which provides very high confidentiality assurance through a secret-sharing mechanism: Health information is cryptographically encoded and distributed in a way that no single and no small group of cloud providers is able to decode it. Results Our results indicate the importance of confidentiality assurance in individuals’ acceptance of health clouds for sensitive medical data. Specifically, this finding holds for a variety of practically relevant circumstances, i.e., in the absence and despite the presence of conventional offline alternatives and along with pseudonymization. On the other hand, we do not find support for the effect of confidentiality assurance in individuals’ acceptance of health clouds for non-sensitive medical data. These results could support the process of privacy engineering for health-cloud solutions. PMID:27781238

49 CFR 1109.3 - Confidentiality in ADR Matters

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 8 2011-10-01 2011-10-01 false Confidentiality in ADR Matters 1109.3 Section 1109... PROCEEDINGS AND THOSE IN WHICH THE BOARD IS A PARTY § 1109.3 Confidentiality in ADR Matters In all ADR matters... provisions of that Act (5 U.S.C. 574) shall bind the Board and all parties and neutrals in those ADR matters...

49 CFR 1109.3 - Confidentiality in ADR Matters

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 8 2010-10-01 2010-10-01 false Confidentiality in ADR Matters 1109.3 Section 1109... PROCEEDINGS AND THOSE IN WHICH THE BOARD IS A PARTY § 1109.3 Confidentiality in ADR Matters In all ADR matters... provisions of that Act (5 U.S.C. 574) shall bind the Board and all parties and neutrals in those ADR matters...

49 CFR 1109.3 - Confidentiality in ADR Matters

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 8 2012-10-01 2012-10-01 false Confidentiality in ADR Matters 1109.3 Section 1109... PROCEEDINGS AND THOSE IN WHICH THE BOARD IS A PARTY § 1109.3 Confidentiality in ADR Matters In all ADR matters... provisions of that Act (5 U.S.C. 574) shall bind the Board and all parties and neutrals in those ADR matters...

7 CFR 1220.624 - Confidentiality.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidentiality. 1220.624 Section 1220.624 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Secretary may direct. ...

The Ethical Issues of Privacy, Confidentiality and Privileged Communication.

ERIC Educational Resources Information Center

Nunnelly, Diane T.

School psychologists and other educators should be concerned about the issues of confidentiality, privacy and privileged communication in regard to school records such as psychological reports and intelligence test scores. Confidentiality relates to matters of professional ethics, privileged communication refers to legal rights, and privacy is a…

36 CFR 290.4 - Confidentiality of cave location information.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Confidentiality of cave location information. 290.4 Section 290.4 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF... organizations assisting the land management agencies with cave management activities. To request confidential...

36 CFR 290.4 - Confidentiality of cave location information.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Confidentiality of cave location information. 290.4 Section 290.4 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF... organizations assisting the land management agencies with cave management activities. To request confidential...

36 CFR 290.4 - Confidentiality of cave location information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Confidentiality of cave location information. 290.4 Section 290.4 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF... organizations assisting the land management agencies with cave management activities. To request confidential...

36 CFR 290.4 - Confidentiality of cave location information.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Confidentiality of cave location information. 290.4 Section 290.4 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF... organizations assisting the land management agencies with cave management activities. To request confidential...

7 CFR 1210.532 - Confidential books, records, and reports.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 10 2012-01-01 2012-01-01 false Confidential books, records, and reports. 1210.532... WATERMELON RESEARCH AND PROMOTION PLAN Rules and Regulations Records § 1210.532 Confidential books, records, and reports. All information obtained from the books, records, and reports of handlers and importers...

7 CFR 1210.532 - Confidential books, records, and reports.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 10 2014-01-01 2014-01-01 false Confidential books, records, and reports. 1210.532... WATERMELON RESEARCH AND PROMOTION PLAN Rules and Regulations Records § 1210.532 Confidential books, records, and reports. All information obtained from the books, records, and reports of handlers and importers...

7 CFR 1210.532 - Confidential books, records, and reports.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential books, records, and reports. 1210.532... WATERMELON RESEARCH AND PROMOTION PLAN Rules and Regulations Records § 1210.532 Confidential books, records, and reports. All information obtained from the books, records, and reports of handlers and importers...

7 CFR 1210.532 - Confidential books, records, and reports.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 10 2011-01-01 2011-01-01 false Confidential books, records, and reports. 1210.532... WATERMELON RESEARCH AND PROMOTION PLAN Rules and Regulations Records § 1210.532 Confidential books, records, and reports. All information obtained from the books, records, and reports of handlers and importers...

7 CFR 1210.532 - Confidential books, records, and reports.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 10 2013-01-01 2013-01-01 false Confidential books, records, and reports. 1210.532... WATERMELON RESEARCH AND PROMOTION PLAN Rules and Regulations Records § 1210.532 Confidential books, records, and reports. All information obtained from the books, records, and reports of handlers and importers...

46 CFR 249.11 - Confidentiality.

Code of Federal Regulations, 2013 CFR

2013-10-01

... top of each page containing information claimed to be confidential. (b) In claiming an exemption under... information in accordance with statutory and decisional authority; and (2) that measures have been taken by...

46 CFR 249.11 - Confidentiality.

Code of Federal Regulations, 2014 CFR

2014-10-01

... top of each page containing information claimed to be confidential. (b) In claiming an exemption under... information in accordance with statutory and decisional authority; and (2) that measures have been taken by...

46 CFR 249.11 - Confidentiality.

Code of Federal Regulations, 2010 CFR

2010-10-01

... top of each page containing information claimed to be confidential. (b) In claiming an exemption under... information in accordance with statutory and decisional authority; and (2) that measures have been taken by...

46 CFR 249.11 - Confidentiality.

Code of Federal Regulations, 2011 CFR

2011-10-01

... top of each page containing information claimed to be confidential. (b) In claiming an exemption under... information in accordance with statutory and decisional authority; and (2) that measures have been taken by...

Violations of medical confidentiality: opinions of primary care physicians

PubMed Central

Elger, Bernice S

2009-01-01

Background Physicians should be able to distinguish situations where they need to protect confidentiality from those where they could be obligated to reveal information. Data are scarce concerning physician's attitudes in daily situations where violations of confidentiality are avoidable. Physicians should be aware of situations where patients are identifiable. Aim To solicit participation of primary care physicians in a teaching intervention and to explore participants' opinions on violations of confidentiality. Design of study A questionnaire presented seven vignettes describing avoidable violations of confidentiality (for example, without patient consent a physician mentions a politician's illness their spouse). Participants answered on a scale of 0–3 (0 = no violation and 3 = serious violation). All contacted physicians were invited to a teaching session during which the study results were discussed. Method Three-hundred and seventy-eight members of the Association of Physicians in Geneva (community physicians) working in primary care medicine, and 130 GPs and internists working at the University Hospital of Geneva (hospital physicians) took part. Physicians' answers were compared to responses from Swiss, UK, and other European law professors, and from 311 medical and law students in Geneva. Results Between 4% (case 6) and 57% (case 2), of physicians thought that no violation occurred. Law professors attributed the scores to each case as 3, 3, 2, 3, 2, 3, 3; the means of physicians were: 1.9, 1.4, 0.7, 1.4 (hospital physicians)/1.9 (community physicians), 0.4, 1.6, 2.6. In most cases, physicians' and students' answers were similar. A significantly higher percentage of community physicians than hospital physicians and students thought that a physician violates confidentiality if they provide the list of their patients to the police for the investigation of the theft of a purse in the waiting room. Conclusion Physicians need to be fully aware of their

Privacy, confidentiality, and security in information systems of state health agencies.

PubMed

O'Brien, D G; Yasnoff, W A

1999-05-01

To assess the employment and status of privacy, confidentiality, security and fair information practices in electronic information systems of U.S. state health agencies. A survey instrument was developed and administered to key contacts within the state health agencies of each of the 50 U.S. states, Puerto Rico and the District of Columbia. About a third of U.S. state health agencies have no written policies in place regarding privacy and confidentiality in electronic information systems. The doctrines of fair information practice often seemed to be ignored. One quarter of the agencies reported at least one security breach during the past two years, and 16% experienced a privacy and confidentiality related transgression. Most of the breaches were committed by personnel from within the agencies. These results raise questions about the integrity of existing privacy, confidentiality and security measures in the information systems of U.S. state health agencies. Recommendations include the development and vigorous enforcement of written privacy and confidentiality policies, increased personnel training, and expanded implementation of security measures such as encryption and system firewalls. A discussion of the current status of U.S. privacy, confidentiality and security issues is offered.

Certificates of confidentiality: a valuable tool for protecting genetic data.

PubMed

Earley, C L; Strong, L C

1995-09-01

Protecting the confidentiality of genetic research data is an important aspect of genetic research that has been discussed in various forums. Research data must be protected to prevent discrimination and its use in litigation. The certificate of confidentiality was created to protect the subjects of alcohol- and drug-abuse studies, who may be engaging in illegal activities. As revised in 1988, the certificate protects investigators engaging in other kinds of studies from being compelled to reveal information about subjects. Because the certificate protects information that could damage a subject's financial or social standing or employability, it is an appropriate tool to use to maintain the confidentiality of genetic data. The Department of Health and Human Services issues the certificates; the procedure for applying for a certificate of confidentiality is presented.

Confidential storage and transmission of medical image data.

PubMed

Norcen, R; Podesser, M; Pommer, A; Schmidt, H-P; Uhl, A

2003-05-01

We discuss computationally efficient techniques for confidential storage and transmission of medical image data. Two types of partial encryption techniques based on AES are proposed. The first encrypts a subset of bitplanes of plain image data whereas the second encrypts parts of the JPEG2000 bitstream. We find that encrypting between 20% and 50% of the visual data is sufficient to provide high confidentiality.

10 CFR 431.407 - Confidentiality.

Code of Federal Regulations, 2011 CFR

2011-01-01

... person submitting information or data which the person believes to be confidential and exempt from public disclosure should submit one complete copy, and 15 copies from which the information believed to be... public disclosure. ...

Library Records: A Review of Confidentiality Laws and Policies.

ERIC Educational Resources Information Center

Million, Angela C.; Fisher, Kim N.

1986-01-01

Cites the importance of having a state law, knowing what it says, and having a library policy statement regarding the confidentiality of patron records. Discussion covers writing and implementing a policy, the role of automation, existing laws, library records defined, exceptions to confidentiality, and legal liability. Thirty-seven references are…

The Qualitative Interview Study of Persistent and Nonpersistent Substance Use in the MTA: Sample Characteristics, Frequent Use, and Reasons for Use.

PubMed

Swanson, James M; Wigal, Timothy; Jensen, Peter S; Mitchell, John T; Weisner, Thomas S; Murray, Desiree; Arnold, L Eugene; Hechtman, Lily; Molina, Brooke S G; Owens, Elizabeth B; Hinshaw, Stephen P; Belendiuk, Katherine; Howard, Andrea; Wigal, Sharon B; Sorensen, Page; Stehli, Annamarie

2017-10-01

To evaluate participants' perceptions about frequent use and reasons for substance use (SU) in the qualitative interview study, an add-on to the multimodal treatment study of ADHD (MTA). Using the longitudinal MTA database, 39 ADHD cases and 19 peers with Persistent SU, and 86 ADHD cases and 39 peers without Persistent SU were identified and recruited. In adulthood, an open-ended interview was administered, and SU excerpts were indexed and classified to create subtopics (frequent use and reasons for use of alcohol, marijuana, and other drugs). For marijuana, the Persistent compared with Nonpersistent SU group had a significantly higher percentage of participants describing frequent use and giving reasons for use, and the ADHD group compared with the group of peers had a significantly higher percentage giving "stability" as a reason for use. Motivations for persistent marijuana use may differ for adults with and without a history of ADHD.

Leptin-induced Epithelial-Mesenchymal Transition in Breast Cancer Cells Requires β-Catenin Activation via Akt/GSK3- and MTA1/Wnt1 Protein-dependent Pathways*

PubMed Central

Yan, Dan; Avtanski, Dimiter; Saxena, Neeraj K.; Sharma, Dipali

2012-01-01

Perturbations in the adipocytokine profile, especially higher levels of leptin, are a major cause of breast tumor progression and metastasis; the underlying mechanisms, however, are not well understood. In particular, it remains elusive whether leptin is involved in epithelial-mesenchymal transition (EMT). Here, we provide molecular evidence that leptin induces breast cancer cells to undergo a transition from epithelial to spindle-like mesenchymal morphology. Investigating the downstream mediator(s) that may direct leptin-induced EMT, we found functional interactions between leptin, metastasis-associated protein 1 (MTA1), and Wnt1 signaling components. Leptin increases accumulation and nuclear translocation of β-catenin leading to increased promoter recruitment. Silencing of β-catenin or treatment with the small molecule inhibitor, ICG-001, inhibits leptin-induced EMT, invasion, and tumorsphere formation. Mechanistically, leptin stimulates phosphorylation of glycogen synthase kinase 3β (GSK3β) via Akt activation resulting in a substantial decrease in the formation of the GSK3β-LKB1-Axin complex that leads to increased accumulation of β-catenin. Leptin treatment also increases Wnt1 expression that contributes to GSK3β phosphorylation. Inhibition of Wnt1 abrogates leptin-stimulated GSK3β phosphorylation. We also discovered that leptin increases the expression of an important modifier of Wnt1 signaling, MTA1, which is integral to leptin-mediated regulation of the Wnt/β-catenin pathway as silencing of MTA1 inhibits leptin-induced Wnt1 expression, GSK3β phosphorylation, and β-catenin activation. Furthermore, analysis of leptin-treated breast tumors shows increased expression of Wnt1, pGSK3β, and vimentin along with higher nuclear accumulation of β-catenin and reduced E-cadherin expression providing in vivo evidence for a previously unrecognized cross-talk between leptin and MTA1/Wnt signaling in epithelial-mesenchymal transition of breast cancer cells. PMID

Treatment of children with attention-deficit/hyperactivity disorder (ADHD) and irritability: results from the multimodal treatment study of children with ADHD (MTA).

PubMed

Fernández de la Cruz, Lorena; Simonoff, Emily; McGough, James J; Halperin, Jeffrey M; Arnold, L Eugene; Stringaris, Argyris

2015-01-01

Clinically impairing irritability affects 25% to 45% of children with attention-deficit/hyperactivity disorder (ADHD); yet, we know little about what interventions are effective in treating children with ADHD and co-occurring irritability. We used data from the Multimodal Treatment Study of Children With ADHD (MTA) to address 3 aims: to establish whether irritability in children with ADHD can be distinguished from other symptoms of oppositional defiant disorder (ODD); to examine whether ADHD treatment is effective in treating irritability; and to examine how irritability influences ADHD treatment outcomes. Secondary analyses of data from the MTA included multivariate analyses, and intent-to-treat random-effects regression models were used. Irritability was separable from other ODD symptoms. For treating irritability, systematic stimulant treatment was superior to behavioral management but not to routine community care; a combination of stimulants and behavioral treatment was superior to community care and to behavioral treatment alone, but not to medication alone. Irritability did not moderate the impact of treatment on parent- and teacher-reported ADHD symptoms in any of the 4 treatment groups. Treatments targeting ADHD symptoms are helpful for improving irritability in children with ADHD. Moreover, irritability does not appear to influence the response to treatment of ADHD. Multimodal Treatment Study of Children With Attention Deficit and Hyperactivity Disorder (MTA); http://www.clinicaltrials.gov; NCT00000388. Copyright © 2015 American Academy of Child & Adolescent Psychaitry. Published by Elsevier Inc. All rights reserved.

40 CFR 725.80 - General provisions for confidentiality claims.

Code of Federal Regulations, 2011 CFR

2011-07-01

... part, including any attachments, for which claims of confidentiality are made, the claim(s) must be... information claimed as confidential in the first copy must be deleted. EPA will place the second copy in the... make the information public and place it in the public file without further notice to the submitter. ...

The MTA at 8 Years: Prospective Follow-Up of Children Treated for Combined Type ADHD in a Multisite Study

PubMed Central

Molina, Brooke S.G.; Hinshaw, Stephen P.; Swanson, James M.; Arnold, L. Eugene; Vitiello, Benedetto; Jensen, Peter S.; Epstein, Jeffery N.; Hoza, Betsy; Hechtman, Lily; Abikoff, Howard B.; Elliott, Glen R.; Greenhill, Laurence L.; Newcorn, Jeffrey H.; Wells, Karen C.; Wigal, Timothy; Gibbons, Robert D.; Hur, Kwan; Houck, Patricia R.

2011-01-01

Objectives To determine any long-term effects, 6 and 8 years after childhood enrollment, of the randomly assigned 14-month treatments in the Multimodal Treatment Study of Children with ADHD (MTA; N=436); to test whether Attention-Deficit/Hyperactivity Disorder (ADHD) symptom trajectory through 3-years predicts outcome in subsequent years; to examine functioning level of the MTA adolescents relative to their non-ADHD peers (Local Normative Comparison Group or LNCG; N=261). Method Mixed effects regression models with planned contrasts at 6- and 8-years tested a wide range of symptom and impairment variables assessed by parent, teacher, and youth report. Results In nearly every analysis, the originally randomized treatment groups did not differ significantly on repeated measures or newly-analyzed variables (e.g., grades earned in school, arrests, psychiatric hospitalizations, or other clinically relevant outcomes). Medication use decreased by 62% after the 14-month controlled trial, but adjusting for this did not change the results. ADHD symptom trajectory in the first 3 years predicted 55% of the outcomes. MTA participants fared worse than LNCG on 91% of the variables tested. Conclusions Type or intensity of 14 months of treatment for ADHD in childhood (at age 7.0–9.9 years old) does not predict functioning six-to-eight years later. Rather, early ADHD symptom trajectory regardless of treatment type is prognostic. This finding implies that children with behavioral and sociodemographic advantage, with the best response to any treatment, will have the best longterm prognosis. As a group, however, despite initial symptom improvement during treatment that is largely maintained post-treatment, children with Combined-Type ADHD exhibit significant impairment in adolescence. Innovative treatment approaches targeting specific areas of adolescent impairment are needed. PMID:19318991

SEALING ABILITY OF GRAY MTA ANGELUS™, CPM™ AND MBPC USED AS APICAL PLUGS

PubMed Central

Orosco, Fernando Accorsi; Bramante, Clovis Monteiro; Garcia, Roberto Brandão; Bernardineli, Norberti; de Moraes, Ivaldo Gomes

2008-01-01

This study evaluated the sealing ability of apical plugs fabricated with gray MTA Angelus™ sealer, CPM™ sealer and MBPc sealer. The root canals of 98 extracted single-rooted human teeth were instrumented with #5 to #1 Gates Glidden drills according to the crown-down technique until the #1 drill could pass through the apical foramen. The specimens were then prepared with K-files, starting with an ISO 50 until an ISO 90 could be visualized 1 mm beyond the apex. After root canal preparation, the external surface of each root was rendered impermeable and roots were assigned to 3 experimental groups (n = 30), which received a 5-mm thick apical plug of gray MTA Angelus™, CPM ™ and MBPc, and two control groups (n=4). The remaining portion of the canal in the experimental groups was filled by the lateral condensation technique. The teeth of each group, properly identified, were fixed on utility wax by their crowns and were placed in plastic flasks, leaving the apex free and facing upward. The flasks were filled with 0.2% Rhodamine B solution, pH 7.0, so as to completely cover the root apex of all teeth. The sealing ability was analyzed by measuring 0.2% Rhodamine B leakage after all groups had been maintained in this solution for 48 hours. Data were analyzed statistically by Kruskal-Wallis test and Dunn test with a=5%. The results showed that, among the tested materials used for fabrication of apical plugs, MBPc sealer had the least amount of leakage with statistically significant difference (p<0.05). PMID:19089289

21 CFR 814.122 - Confidentiality of data and information.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Confidentiality of data and information. (a) Requirement for disclosure. The “HDE file” includes all data and... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Confidentiality of data and information. 814.122... record in the HDE file will be available for public disclosure in accordance with the provisions of this...

21 CFR 814.122 - Confidentiality of data and information.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Confidentiality of data and information. (a) Requirement for disclosure. The “HDE file” includes all data and... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Confidentiality of data and information. 814.122... record in the HDE file will be available for public disclosure in accordance with the provisions of this...

21 CFR 814.122 - Confidentiality of data and information.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Confidentiality of data and information. (a) Requirement for disclosure. The “HDE file” includes all data and... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Confidentiality of data and information. 814.122... record in the HDE file will be available for public disclosure in accordance with the provisions of this...

21 CFR 814.122 - Confidentiality of data and information.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Confidentiality of data and information. (a) Requirement for disclosure. The “HDE file” includes all data and... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Confidentiality of data and information. 814.122... record in the HDE file will be available for public disclosure in accordance with the provisions of this...

21 CFR 20.55 - Indexing trade secrets and confidential commercial or financial information.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Indexing trade secrets and confidential commercial... secrets and confidential commercial or financial information. Whenever the Food and Drug Administration... exempt from public disclosure as trade secret or confidential commercial or financial data and...

21 CFR 20.55 - Indexing trade secrets and confidential commercial or financial information.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Indexing trade secrets and confidential commercial... secrets and confidential commercial or financial information. Whenever the Food and Drug Administration... exempt from public disclosure as trade secret or confidential commercial or financial data and...

21 CFR 20.55 - Indexing trade secrets and confidential commercial or financial information.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Indexing trade secrets and confidential commercial... secrets and confidential commercial or financial information. Whenever the Food and Drug Administration... exempt from public disclosure as trade secret or confidential commercial or financial data and...

21 CFR 20.55 - Indexing trade secrets and confidential commercial or financial information.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Indexing trade secrets and confidential commercial... secrets and confidential commercial or financial information. Whenever the Food and Drug Administration... exempt from public disclosure as trade secret or confidential commercial or financial data and...

21 CFR 20.55 - Indexing trade secrets and confidential commercial or financial information.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Indexing trade secrets and confidential commercial... secrets and confidential commercial or financial information. Whenever the Food and Drug Administration... exempt from public disclosure as trade secret or confidential commercial or financial data and...

40 CFR 716.55 - Confidentiality claims.

Code of Federal Regulations, 2011 CFR

2011-07-01

... for commercial distribution (including for test marketing purposes and for use in research and... because disclosure would reveal a confidential process or quantitative mixture composition should briefly...

40 CFR 716.55 - Confidentiality claims.

Code of Federal Regulations, 2010 CFR

2010-07-01

... for commercial distribution (including for test marketing purposes and for use in research and... because disclosure would reveal a confidential process or quantitative mixture composition should briefly...

40 CFR 716.55 - Confidentiality claims.

Code of Federal Regulations, 2013 CFR

2013-07-01

... for commercial distribution (including for test marketing purposes and for use in research and... because disclosure would reveal a confidential process or quantitative mixture composition should briefly...

40 CFR 716.55 - Confidentiality claims.

Code of Federal Regulations, 2012 CFR

2012-07-01

... for commercial distribution (including for test marketing purposes and for use in research and... because disclosure would reveal a confidential process or quantitative mixture composition should briefly...

40 CFR 716.55 - Confidentiality claims.

Code of Federal Regulations, 2014 CFR

2014-07-01

... for commercial distribution (including for test marketing purposes and for use in research and... because disclosure would reveal a confidential process or quantitative mixture composition should briefly...

29 CFR 1208.5 - Material relating to mediation function-confidential.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false Material relating to mediation function-confidential. 1208.5 Section 1208.5 Labor Regulations Relating to Labor (Continued) NATIONAL MEDIATION BOARD AVAILABILITY OF INFORMATION § 1208.5 Material relating to mediation function—confidential. (a) All files...

5 CFR 1312.26 - Control of secret and confidential material.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Control of secret and confidential... Accountability of Classified Information § 1312.26 Control of secret and confidential material. Classified... Document Control, will be used to establish accountability controls on all Secret material received or...

16 CFR 1702.6 - Trade secrets and other confidential information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Trade secrets and other confidential information. 1702.6 Section 1702.6 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION...; PETITION PROCEDURES AND REQUIREMENTS § 1702.6 Trade secrets and other confidential information. Where a...

16 CFR 1702.6 - Trade secrets and other confidential information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Trade secrets and other confidential information. 1702.6 Section 1702.6 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION...; PETITION PROCEDURES AND REQUIREMENTS § 1702.6 Trade secrets and other confidential information. Where a...

5 CFR 1312.26 - Control of secret and confidential material.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Control of secret and confidential... Accountability of Classified Information § 1312.26 Control of secret and confidential material. Classified... Document Control, will be used to establish accountability controls on all Secret material received or...

5 CFR 1312.26 - Control of secret and confidential material.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Control of secret and confidential... Accountability of Classified Information § 1312.26 Control of secret and confidential material. Classified... Document Control, will be used to establish accountability controls on all Secret material received or...

16 CFR 1702.6 - Trade secrets and other confidential information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Trade secrets and other confidential information. 1702.6 Section 1702.6 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION...; PETITION PROCEDURES AND REQUIREMENTS § 1702.6 Trade secrets and other confidential information. Where a...

16 CFR 1702.6 - Trade secrets and other confidential information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Trade secrets and other confidential information. 1702.6 Section 1702.6 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION...; PETITION PROCEDURES AND REQUIREMENTS § 1702.6 Trade secrets and other confidential information. Where a...

5 CFR 1312.26 - Control of secret and confidential material.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Control of secret and confidential... Accountability of Classified Information § 1312.26 Control of secret and confidential material. Classified... Document Control, will be used to establish accountability controls on all Secret material received or...

Confidentiality issues for medical data miners.

PubMed

Berman, Jules J

2002-01-01

The first task in any medical data mining effort is ensuring patient confidentiality. In the past, most data mining efforts ensured confidentiality by the dubious policy of withholding their raw data from colleagues and the public. A cursory review of medical informatics literature in the past decade reveals that much of what we have "learned" consists of assertions derived from confidential datasets unavailable for anyone's review. Without access to the original data, it is impossible to validate or improve upon a researcher's conclusions. Without access to research data, we are asked to accept findings as an act of faith, rather than as a scientific conclusion. This special issue of Artificial Intelligence in Medicine is devoted to medical data mining. The medical data miner has an obligation to conduct valid research in a way that protects human subjects. Today, data miners have the technical tools to merge large data collections and to distribute queries over disparate databases. In order to include patient-related data in shared databases, data miners will need methods to anonymize and deidentify data. This article reviews the human subject risks associated with medical data mining. This article also describes some of the innovative computational remedies that will permit researchers to conduct research AND share their data without risk to patient or institution.

28 CFR 42.603 - Confidentiality.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Confidentiality. 42.603 Section 42.603 Judicial Administration DEPARTMENT OF JUSTICE NONDISCRIMINATION; EQUAL EMPLOYMENT OPPORTUNITY; POLICIES AND PROCEDURES Procedures for Complaints of Employment Discrimination Filed Against Recipients of Federal...

Confidential Business Information under TSCA

EPA Pesticide Factsheets

This website informs businesses, policymakers, and the public about the confidential business information (CBI) provisions of § 14 of the Toxic Substances Control Act (TSCA), as amended by the Frank R. Lautenberg Chemical Safety for the 21st Century Act.

30 CFR 291.111 - How does MMS treat the confidential information I provide?

Code of Federal Regulations, 2010 CFR

2010-07-01

... INTERIOR APPEALS OPEN AND NONDISCRIMINATORY ACCESS TO OIL AND GAS PIPELINES UNDER THE OUTER CONTINENTAL... a particular document is confidential. If you claim confidential treatment, then when you provide... that copy that you are making a request for confidential treatment for some or all of the information...

6 CFR 25.10 - Confidentiality and protection of Intellectual Property.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Confidentiality and protection of Intellectual Property. 25.10 Section 25.10 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY REGULATIONS TO SUPPORT ANTI-TERRORISM BY FOSTERING EFFECTIVE TECHNOLOGIES § 25.10 Confidentiality and...