Sample records for agreements agency pi

  1. Mexican Space Agency and NASA Agreement

    NASA Image and Video Library

    2013-03-18

    John Grunsfeld (far left), Associate Administrator for the Science Mission Directorate at NASA Headquarters, Dr. Francisco Javier Mendieta Jimenez, Director General of the Mexican Space Agency, NASA Administrator Charles Bolden, Leland Melvin, NASA Associate Administrator for Education and Al Condes (far right), Deputy Associate Administrator for International and Interagency Relations pose for a photo, Monday, March 18, 2013 at NASA Headquarters in Washington. A Reimbursable Space Act Agreement (RSAA) for a NASA International Internship Program was signed between the two agencies. This is the first NASA-Mexico agreement signed. Photo Credit: (NASA/Carla Cioffi)

  2. 40 CFR 35.6250 - Support agency Cooperative Agreement requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund Response Actions Support Agency Cooperative Agreements § 35.6250 Support agency...

  3. 40 CFR 35.6250 - Support agency Cooperative Agreement requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund Response Actions Support Agency Cooperative Agreements § 35.6250 Support agency...

  4. 40 CFR 35.6250 - Support agency Cooperative Agreement requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund Response Actions Support Agency Cooperative Agreements § 35.6250 Support agency...

  5. 40 CFR 35.6250 - Support agency Cooperative Agreement requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund Response Actions Support Agency Cooperative Agreements § 35.6250 Support agency...

  6. 20 CFR 617.59 - Agreements with State agencies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Agreements with State agencies. 617.59 Section 617.59 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR TRADE... § 617.59 Agreements with State agencies. (a) Authority. Before performing any function or exercising any...

  7. All over the map: An interobserver agreement study of tumor location based on the PI-RADSv2 sector map.

    PubMed

    Greer, Matthew D; Shih, Joanna H; Barrett, Tristan; Bednarova, Sandra; Kabakus, Ismail; Law, Yan Mee; Shebel, Haytham; Merino, Maria J; Wood, Bradford J; Pinto, Peter A; Choyke, Peter L; Turkbey, Baris

    2018-01-17

    Prostate imaging reporting and data system version 2 (PI-RADSv2) recommends a sector map for reporting findings of prostate cancer mulitparametric MRI (mpMRI). Anecdotally, radiologists may demonstrate inconsistent reproducibility with this map. To evaluate interobserver agreement in defining prostate tumor location on mpMRI using the PI-RADSv2 sector map. Retrospective. Thirty consecutive patients who underwent mpMRI between October, 2013 and March, 2015 and who subsequently underwent prostatectomy with whole-mount processing. 3T mpMRI with T 2 W, diffusion-weighted imaging (DWI) (apparent diffusion coefficient [ADC] and b-2000), dynamic contrast-enhanced (DCE). Six radiologists (two high, two intermediate, and two low experience) from six institutions participated. Readers were blinded to lesion location and detected up to four lesions as per PI-RADSv2 guidelines. Readers marked the long-axis of lesions, saved screen-shots of each lesion, and then marked the lesion location on the PI-RADSv2 sector map. Whole-mount prostatectomy specimens registered to the MRI served as ground truth. Index lesions were defined as the highest grade lesion or largest lesion if grades were equivalent. Agreement was calculated for the exact, overlap, and proportion of agreement. Readers detected an average of 1.9 lesions per patient (range 1.6-2.3). 96.3% (335/348) of all lesions for all readers were scored PI-RADS ≥3. Readers defined a median of 2 (range 1-18) sectors per lesion. Agreement for detecting index lesions by screen shots was 83.7% (76.1%-89.9%) vs. 71.0% (63.1-78.3%) overlap agreement on the PI-RADS sector map (P < 0.001). Exact agreement for defining sectors of detected index lesions was only 21.2% (95% confidence interval [CI]: 14.4-27.7%) and rose to 49.0% (42.4-55.3%) when overlap was considered. Agreement on defining the same level of disease (ie, apex, mid, base) was 61.4% (95% CI 50.2-71.8%). Readers are highly likely to detect the same index lesion on mpMRI, but

  8. Agency Agreements Process Champion Support Intern

    NASA Technical Reports Server (NTRS)

    Miksa, Ember

    2018-01-01

    This document will provide information on the 2018 Spring semester NIFS Intern who represented the Office of Chief Financial Officer (OCFO) as a Reimbursable Accountant at Kennedy Space Center (KSC). This intern supported the Agency Agreements Process Champions and Team Lead, Susan Kroskey, Sandy Massey and Mecca Murphy, with major initiatives to advance the KSC OCFO's vision of creating and innovating healthy financial management practices that maximize the value of resources entrusted to NASA. These initiatives include, but are not limited to: updating the Agency Guidance and NASA Procedural Guidance 9090.1 Agreements, implementing a new budget structure to be utilized across all centers, submitting a Call Request (CRQ) to enhance non-federal customer reporting, initiating a discussion to incorporate a 3-year funding program for NASA agreements, and undertaking the Office of Inspector General (OIG) Audit. In support of these initiatives, this intern identified technical methods to enhance and reduce the workload of financial processes for reimbursable and non-reimbursable agreements, prepared reports in support of accounting functions, and performed administrative work and miscellaneous technical tasks in support of the OCFO as requested. In conclusion of the internship, the intern will become knowledgeable on reimbursable accounting, reimbursable policy, types of reimbursable agreements, the agreements process, estimated pricing reports, and the roles and responsibilities of the Financial Accounting and Financial Services offices.

  9. Mexican Space Agency and NASA Agreement

    NASA Image and Video Library

    2013-03-18

    NASA Administrator Charles Bolden (center) presents Dr. Francisco Javier Mendieta Jimenez, Director General of the Mexican Space Agency, a NASA montage in honor of the Reimbursable Space Act Agreement (RSAA) signed between the two agencies, Monday, March 18, 2013 at NASA Headquarters in Washington. Leland Melvin (right), NASA Associate Administrator for Education looks on. The International Internship Program is a pilot program developed at NASA which will provide and avenue for non-US students to come to NASA for an internship. US students will be paired with a foreign student to work on a NASA research project under the guidance of a mentor. This is the first NASA-Mexico agreement signed. Photo Credit: (NASA/Carla Cioffi)

  10. 46 CFR 535.304 - Agency agreements-exemption.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 9 2011-10-01 2011-10-01 false Agency agreements-exemption. 535.304 Section 535.304 Shipping FEDERAL MARITIME COMMISSION REGULATIONS AFFECTING OCEAN SHIPPING IN FOREIGN COMMERCE OCEAN COMMON CARRIER AND MARINE TERMINAL OPERATOR AGREEMENTS SUBJECT TO THE SHIPPING ACT OF 1984 Exemptions § 535.304...

  11. 46 CFR 308.8 - War risk insurance underwriting agency agreement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false War risk insurance underwriting agency agreement. 308.8 Section 308.8 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE General § 308.8 War risk insurance underwriting agency agreement. Standard form MA-355 of...

  12. 46 CFR 308.8 - War risk insurance underwriting agency agreement.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false War risk insurance underwriting agency agreement. 308.8 Section 308.8 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE General § 308.8 War risk insurance underwriting agency agreement. Standard form MA-355...

  13. 46 CFR 308.8 - War risk insurance underwriting agency agreement.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false War risk insurance underwriting agency agreement. 308.8 Section 308.8 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE General § 308.8 War risk insurance underwriting agency agreement. Standard form MA-355 of...

  14. 46 CFR 308.8 - War risk insurance underwriting agency agreement.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false War risk insurance underwriting agency agreement. 308.8 Section 308.8 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE General § 308.8 War risk insurance underwriting agency agreement. Standard form MA-355 of...

  15. 46 CFR 308.8 - War risk insurance underwriting agency agreement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false War risk insurance underwriting agency agreement. 308.8 Section 308.8 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE General § 308.8 War risk insurance underwriting agency agreement. Standard form MA-355 of...

  16. 40 CFR 35.6240 - Eligibility for support agency Cooperative Agreements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund Response Actions Support Agency Cooperative Agreements § 35.6240 Eligibility for...

  17. 40 CFR 35.6240 - Eligibility for support agency Cooperative Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund Response Actions Support Agency Cooperative Agreements § 35.6240 Eligibility for...

  18. 40 CFR 35.6240 - Eligibility for support agency Cooperative Agreements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund Response Actions Support Agency Cooperative Agreements § 35.6240 Eligibility for...

  19. 40 CFR 35.6240 - Eligibility for support agency Cooperative Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund Response Actions Support Agency Cooperative Agreements § 35.6240 Eligibility for...

  20. Mexican Space Agency and NASA Agreement

    NASA Image and Video Library

    2013-03-18

    Leland Melvin (right), NASA Associate Administrator for Education, along with the head of the Mexican Space Agency, Dr. Francisco Javier Mendieta Jimenez shake hands after signing a Reimbursable Space Act Agreement (RSAA) for a NASA International Internship Program as NASA Administrator Charles Bolden looks on, Monday, March 18, 2013 at NASA Headquarters in Washington. The International Internship Program is a pilot program developed at NASA which will provide and avenue for non-US students to come to NASA for an internship. US students will be paired with a foreign student to work on a NASA research project under the guidance of a mentor. This is the first NASA-Mexico agreement signed. Photo Credit: (NASA/Carla Cioffi)

  1. Mexican Space Agency and NASA Agreement

    NASA Image and Video Library

    2013-03-18

    Leland Melvin (right), NASA Associate Administrator for Education, along with the head of the Mexican Space Agency, Dr. Francisco Javier Mendieta Jimenez pose for a photo after signing a Reimbursable Space Act Agreement (RSAA) for a NASA International Internship Program as NASA Administrator Charles Bolden looks on, Monday, March 18, 2013 at NASA Headquarters in Washington. The International Internship Program is a pilot program developed at NASA which will provide and avenue for non-US students to come to NASA for an internship. US students will be paired with a foreign student to work on a NASA research project under the guidance of a mentor. This is the first NASA-Mexico agreement signed. Photo Credit: (NASA/Carla Cioffi)

  2. 34 CFR 682.400 - Agreements between a guaranty agency and the Secretary.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FEDERAL FAMILY EDUCATION LOAN (FFEL) PROGRAM Administration of the Federal Family Education Loan Programs by a Guaranty Agency § 682.400 Agreements between a... 34 Education 3 2010-07-01 2010-07-01 false Agreements between a guaranty agency and the Secretary...

  3. Direct comparison of PI-RADS version 2 and version 1 regarding interreader agreement and diagnostic accuracy for the detection of clinically significant prostate cancer.

    PubMed

    Becker, Anton S; Cornelius, Alexander; Reiner, Cäcilia S; Stocker, Daniel; Ulbrich, Erika J; Barth, Borna K; Mortezavi, Ashkan; Eberli, Daniel; Donati, Olivio F

    2017-09-01

    to simultaneously evaluate interreader agreement and diagnostic accuracy in the of PI-RADS v2 and compare it to v1. A total of 67 patients (median age 65.3 y, range 51.2-78.2 y; PSA 6.8μg/L, 0.2-33μg/L) undergoing MRI of the prostate and subsequent transperineal template biopsy within ≤6 months from MRI were included. Four readers from two institutions evaluated the likelihood of prostate cancer using PI-RADS v1 and v2 in two separate reading sessions ≥3 months apart. Interreader agreement was assessed for each pulse-sequence and for total PI-RADS scores using the intraclass correlation coefficient (ICC). Differences were considered significant for non-overlapping 95%-confidence intervals. Diagnostic accuracy was assessed with the area under the receiver operating characteristic curve (A Z ). A p-value <0.05 was considered statistically significant. Interreader agreement for DCE-scores was good in v2 (ICC 2 =0.70; 95% CI: 0.66-0.74) and slightly lower in v1 (ICC 1 =0.64, 0.59-0.69). Agreement for DWI scores (ICC 1 =0.77, ICC 2 =0.76) as well as final PI-RADS scores per quadrant were nearly identical (ICC 1 =ICC 2 =0.71). Diagnostic accuracy showed no significant differences (p=0.09-0.93) between v1 and v2 in any of the readers (range: A Z =0.78-0.88). PI-RADS scores show similar interreader agreement in v2 and v1 at comparable diagnostic performance. The simplification of the DCE interpretation in v2 might slightly improve agreement while not negatively affecting diagnostic performance. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. 77 FR 6137 - Agency Information Collection Activities: Guam-CNMI Visa Waiver Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... Activities: Guam-CNMI Visa Waiver Agreement AGENCY: U.S. Customs and Border Protection, Department of... comment on an information collection requirement concerning the Guam-CNMI Visa Waiver Agreement (CBP Form... information collection: Title: Guam-CNMI Visa Waiver Agreement. OMB Number: 1651-0126. Form Number: CBP Form I...

  5. Observation of pi+pi-pi+pi- photoproduction in ultraperipheral heavy-ion collisions at sqrt sNN = 200 GeV at the STAR detector

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    STAR Collaboration; Abelev, Betty

    We present a measurement of {pi}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -} photonuclear production in ultra-peripheral Au-Au collisions at {radical}s{sub NN} = 200 GeV from the STAR experiment. The {pi}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -} final states are observed at low transverse momentum and are accompanied by mutual nuclear excitation of the beam particles. The strong enhancement of the production cross section at low transverse momentum is consistent with coherent photoproduction. The {pi}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -} invariant mass spectrum of the coherent events exhibits a broad peak around 1540 {+-} 40 MeV/c{sup 2} with a width of 570 {+-} 60 MeV/c{sup 2},more » in agreement with the photoproduction data for the {rho}{sup 0}(1700). We do not observe a corresponding peak in the {pi}{sup +}{pi}{sup -} final state and measure an upper limit for the ratio of the branching fractions of the {rho}{sup 0}(1700) to {pi}{sup +}{pi}{sup -} and {pi}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -} of 2.5% at 90% confidence level. The ratio of {rho}{sup 0}(1700) and {rho}{sup 0}(770) coherent production cross sections is measured to be 13.4 {+-} 0.8{sub stat.} {+-} 4.4{sub syst.}%.« less

  6. Observation of pi+ pi- pi+pi- photoproduction in ultraperipheral heavy-ion collisons at sqrt sNN = 200 GeV at the STAR Detector

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Abelev, B.I.; Dunlop, J.; et al. STAR Collaboration

    We present a measurement of {pi}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -} photonuclear production in ultraperipheral Au-Au collisions at {radical}s{sub NN} = 200 GeV from the STAR experiment. The {pi}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -} final states are observed at low transverse momentum and are accompanied by mutual nuclear excitation of the beam particles. The strong enhancement of the production cross section at low transverse momentum is consistent with coherent photoproduction. The {pi}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -} invariant mass spectrum of the coherent events exhibits a broad peak around 1540 {+-} 40 MeV/c{sup 2} with a width of 570 {+-} 60 MeV/c{sup 2},more » in agreement with the photoproduction data for the {rho}{sup 0}(1700). We do not observe a corresponding peak in the {pi}{sup +}{pi}{sup -} final state and measure an upper limit for the ratio of the branching fractions of the {rho}{sup 0}(1700) to {pi}{sup +}{pi}{sup -} and {pi}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -} of 2.5% at 90% confidence level. The ratio of {rho}{sup 0}(1700) and {rho}{sup 0}(770) coherent production cross sections is measured to be 13.4 {+-} 0.8{sub stat.}{+-}4.4{sub syst.}%.« less

  7. 20 CFR 411.415 - Who will verify the establishment of agreements between ENs and State VR agencies?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... agreements between ENs and State VR agencies? 411.415 Section 411.415 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.415 Who will verify the establishment of agreements between ENs and State VR agencies? The PM will verify the establishment of these...

  8. 20 CFR 411.415 - Who will verify the establishment of agreements between ENs and State VR agencies?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... agreements between ENs and State VR agencies? 411.415 Section 411.415 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.415 Who will verify the establishment of agreements between ENs and State VR agencies? The PM will verify the establishment of these...

  9. Application of Prostate Imaging Reporting and Data System Version 2 (PI-RADS v2): Interobserver Agreement and Positive Predictive Value for Localization of Intermediate- and High-Grade Prostate Cancers on Multiparametric Magnetic Resonance Imaging.

    PubMed

    Chen, Frank; Cen, Steven; Palmer, Suzanne

    2017-09-01

    To evaluate interobserver agreement with the use of and the positive predictive value (PPV) of Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) for the localization of intermediate- and high-grade prostate cancers on multiparametric magnetic resonance imaging (mpMRI). In this retrospective, institutional review board-approved study, 131 consecutive patients who had mpMRI followed by transrectal ultrasound-MR imaging fusion-guided biopsy of the prostate were included. Two readers who were blinded to initial mpMRI reports, clinical data, and pathologic outcomes reviewed the MR images, identified all prostate lesions, and scored each lesion based on the PI-RADS v2. Interobserver agreement was assessed by intraclass correlation coefficient (ICC), and PPV was calculated for each PI-RADS category. PI-RADS v2 was found to have a moderate level of interobserver agreement between two readers of varying experience, with ICC of 0.74, 0.72, and 0.67 for all lesions, peripheral zone lesions, and transitional zone lesions, respectively. Despite only moderate interobserver agreement, the calculated PPV in the detection of intermediate- and high-grade prostate cancers for each PI-RADS category was very similar between the two readers, with approximate PPV of 0%, 12%, 64%, and 87% for PI-RADS categories 2, 3, 4, and 5, respectively. In our study, PI-RADS v2 has only moderate interobserver agreement, a similar finding in studies of the original PI-RADS and in initial studies of PI-RADS v2. Despite this, PI-RADS v2 appears to be a useful system to predict significant prostate cancer, with PI-RADS scores correlating well with the likelihood of intermediate- and high-grade cancers. Copyright © 2017 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

  10. 20 CFR 411.435 - How will disputes arising under the agreements between ENs and State VR agencies be resolved?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... agreements between ENs and State VR agencies be resolved? 411.435 Section 411.435 Employees' Benefits SOCIAL... Vr Agencies § 411.435 How will disputes arising under the agreements between ENs and State VR agencies be resolved? Disputes arising under agreements between ENs and State VR agencies must be resolved...

  11. 20 CFR 411.435 - How will disputes arising under the agreements between ENs and State VR agencies be resolved?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... agreements between ENs and State VR agencies be resolved? 411.435 Section 411.435 Employees' Benefits SOCIAL... Vr Agencies § 411.435 How will disputes arising under the agreements between ENs and State VR agencies be resolved? Disputes arising under agreements between ENs and State VR agencies must be resolved...

  12. PI-RADS v2: Current standing and future outlook.

    PubMed

    Smith, Clayton P; Türkbey, Barış

    2018-05-01

    The Prostate Imaging-Reporting and Data System (PI-RADS) was created in 2012 to establish standardization in prostate multiparametric magnetic resonance imaging (mpMRI) acquisition, interpretation, and reporting. In hopes of improving upon some of the PI-RADS v1 shortcomings, the PI-RADS Steering Committee released PI-RADS v2 in 2015. This paper reviews the accuracy, interobserver agreement, and clinical outcomes of PI-RADS v2 and comments on the limitations of the current literature. Overall, PI-RADS v2 shows improved sensitivity and similar specificity compared to PI-RADS v1. However, concerns exist regarding interobserver agreement and the heterogeneity of the study methodology.

  13. PI-RADS v2: Current standing and future outlook

    PubMed Central

    Smith, Clayton P.

    2018-01-01

    The Prostate Imaging-Reporting and Data System (PI-RADS) was created in 2012 to establish standardization in prostate multiparametric magnetic resonance imaging (mpMRI) acquisition, interpretation, and reporting. In hopes of improving upon some of the PI-RADS v1 shortcomings, the PI-RADS Steering Committee released PI-RADS v2 in 2015. This paper reviews the accuracy, interobserver agreement, and clinical outcomes of PI-RADS v2 and comments on the limitations of the current literature. Overall, PI-RADS v2 shows improved sensitivity and similar specificity compared to PI-RADS v1. However, concerns exist regarding interobserver agreement and the heterogeneity of the study methodology. PMID:29733790

  14. 76 FR 6845 - Agency Information Collection (Certificate of Affirmation of Enrollment Agreement for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-08

    ... (Certificate of Affirmation of Enrollment Agreement for Correspondence Course) Activity Under OMB Review AGENCY....'' SUPPLEMENTARY INFORMATION: Title: Certificate of Affirmation of Enrollment Agreement for Correspondence Course... collection. Abstract: Claimants enrolled in a correspondence training course complete and submit VA Form 22...

  15. Observation of pi{sup +}pi{sup -}pi{sup +}pi{sup -} photoproduction in ultraperipheral heavy-ion collisions at sq root(s{sub NN})=200 GeV at the STAR detector

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Abelev, B. I.; Betts, R. R.; Evdokimov, O.

    We present a measurement of pi{sup +}pi{sup -}pi{sup +}pi{sup -} photonuclear production in ultraperipheral Au-Au collisions at sq root(s{sub N{sub N}})=200 GeV from the STAR experiment. The pi{sup +}pi{sup -}pi{sup +}pi{sup -} final states are observed at low transverse momentum and are accompanied by mutual nuclear excitation of the beam particles. The strong enhancement of the production cross section at low transverse momentum is consistent with coherent photoproduction. The pi{sup +}pi{sup -}pi{sup +}pi{sup -} invariant mass spectrum of the coherent events exhibits a broad peak around 1540+-40 MeV/c{sup 2} with a width of 570+-60 MeV/c{sup 2}, in agreement with themore » photoproduction data for the rho{sup 0}(1700). We do not observe a corresponding peak in the pi{sup +}pi{sup -} final state and measure an upper limit for the ratio of the branching fractions of the rho{sup 0}(1700) to pi{sup +}pi{sup -} and pi{sup +}pi{sup -}pi{sup +}pi{sup -} of 2.5% at 90% confidence level. The ratio of rho{sup 0}(1700) and rho{sup 0}(770) coherent production cross sections is measured to be 13.4+-0.8{sub stat.}+-4.4{sub syst.}%.« less

  16. 20 CFR 411.420 - What information should be included in an agreement between an EN and a State VR agency?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... agreement between an EN and a State VR agency? 411.420 Section 411.420 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.420 What information should be included in an agreement between an EN and a State VR agency? The agreement between an EN and a State VR...

  17. 20 CFR 411.420 - What information should be included in an agreement between an EN and a State VR agency?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... agreement between an EN and a State VR agency? 411.420 Section 411.420 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.420 What information should be included in an agreement between an EN and a State VR agency? The agreement between an EN and a State VR...

  18. 29 CFR 1626.10 - Agreements with State or local fair employment practices agencies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 4 2013-07-01 2013-07-01 false Agreements with State or local fair employment practices agencies. 1626.10 Section 1626.10 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.10 Agreements with State or...

  19. 29 CFR 1626.10 - Agreements with State or local fair employment practices agencies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 4 2014-07-01 2014-07-01 false Agreements with State or local fair employment practices agencies. 1626.10 Section 1626.10 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.10 Agreements with State or...

  20. 29 CFR 1626.10 - Agreements with State or local fair employment practices agencies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 4 2012-07-01 2012-07-01 false Agreements with State or local fair employment practices agencies. 1626.10 Section 1626.10 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.10 Agreements with State or...

  1. 29 CFR 1626.10 - Agreements with State or local fair employment practices agencies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 4 2011-07-01 2011-07-01 false Agreements with State or local fair employment practices agencies. 1626.10 Section 1626.10 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.10 Agreements with State or...

  2. 29 CFR 1626.10 - Agreements with State or local fair employment practices agencies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Agreements with State or local fair employment practices agencies. 1626.10 Section 1626.10 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.10 Agreements with State or...

  3. Measurements of total production cross sections for $$\\pi^{+}$$+C, $$\\pi^{+}$$+Al, $$K^{+}$$+C, and $$K^{+}$$+Al at 60 GeV/c and $$\\pi^{+}$$+C and $$\\pi^{+}$$+Al at 31 GeV/c

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aduszkiewicz, A.; et al.

    This paper presents several measurements of total production cross sections and total inelastic cross sections for the following reactions:more » $$\\pi^{+}$$+C, $$\\pi^{+}$$+Al, $$K^{+}$$+C, $$K^{+}$$+Al at 60 GeV/c, $$\\pi^{+}$$+C and $$\\pi^{+}$$+Al at 31 GeV/c . The measurements were made using the NA61/SHINE spectrometer at the CERN SPS. Comparisons with previous measurements are given and good agreement is seen. These interaction cross sections measurements are a key ingredient for neutrino flux prediction from the reinteractions of secondary hadrons in current and future accelerator-based long-baseline neutrino experiments.« less

  4. 20 CFR 411.415 - Who will verify the establishment of agreements between ENs and State VR agencies?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Who will verify the establishment of agreements between ENs and State VR agencies? 411.415 Section 411.415 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.415 Who will verify the...

  5. 20 CFR 411.415 - Who will verify the establishment of agreements between ENs and State VR agencies?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Who will verify the establishment of agreements between ENs and State VR agencies? 411.415 Section 411.415 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.415 Who will verify the...

  6. 20 CFR 411.415 - Who will verify the establishment of agreements between ENs and State VR agencies?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Who will verify the establishment of agreements between ENs and State VR agencies? 411.415 Section 411.415 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.415 Who will verify the...

  7. 20 CFR 411.405 - When does an agreement between an EN and the State VR agency have to be in place?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... State VR agency have to be in place? 411.405 Section 411.405 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.405 When does an agreement between an EN and the State VR agency have to be in place? Each EN must have an agreement with the State...

  8. 20 CFR 411.405 - When does an agreement between an EN and the State VR agency have to be in place?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... State VR agency have to be in place? 411.405 Section 411.405 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.405 When does an agreement between an EN and the State VR agency have to be in place? Each EN must have an agreement with the State...

  9. 78 FR 19726 - Agency Information Collection Activities: Visa Waiver Program Carrier Agreement (CBP Form I-775)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ... Activities: Visa Waiver Program Carrier Agreement (CBP Form I-775) AGENCY: U.S. Customs and Border Protection... information collection requirement concerning the Visa Waiver Program Carrier Agreement (CBP Form I-775). This... concerning the following information collection: Title: Visa Waiver Program Carrier Agreement. OMB Number...

  10. 20 CFR 411.410 - Does each referral from an EN to a State VR agency require its own agreement?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Does each referral from an EN to a State VR...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.410 Does each referral from an EN to a State VR agency require its own agreement? No. The agreements between ENs and State VR...

  11. 20 CFR 411.410 - Does each referral from an EN to a State VR agency require its own agreement?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Does each referral from an EN to a State VR...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.410 Does each referral from an EN to a State VR agency require its own agreement? No. The agreements between ENs and State VR...

  12. 75 FR 16173 - Renewal of Agency Information Collection for Tribal Energy Resource Agreements; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Renewal of Agency Information Collection for Tribal Energy Resource Agreements; Comment Request AGENCY: Bureau of Indian Affairs, Interior. [[Page... Department of the Interior at the Office of Management and Budget, by facsimile to (202) 395-5806 or you may...

  13. Dalitz Plot Analyses of B- to D+ Pi- Pi-, B+ to Pi+ Pi- Pi+ and D(S)+ to Pi+ Pi- Pi+ at BaBar

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dong, Liaoyuan; /Iowa State U.

    We report on the Dalitz plot analyses of B{sup -} {yields} D{sup +}{pi}{sup -}{pi}{sup -}, B{sup +} {yields} {pi}{sup +}{pi}{sup -}{pi}{sup +} and D{sub s}{sup +} {yields} {pi}{sup +}{pi}{sup -}{sup +}. The Dalitz plot method and the most recent BABAR results are discussed.

  14. 42 CFR 1007.9 - Relationship to, and agreement with, the Medicaid agency.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Relationship to, and agreement with, the Medicaid agency. 1007.9 Section 1007.9 Public Health OFFICE OF INSPECTOR GENERAL-HEALTH CARE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OIG AUTHORITIES STATE MEDICAID FRAUD CONTROL UNITS § 1007.9 Relationship to, and...

  15. 20 CFR 411.410 - Does each referral from an EN to a State VR agency require its own agreement?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Does each referral from an EN to a State VR agency require its own agreement? 411.410 Section 411.410 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.410 Does each referral from an...

  16. 20 CFR 411.410 - Does each referral from an EN to a State VR agency require its own agreement?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Does each referral from an EN to a State VR agency require its own agreement? 411.410 Section 411.410 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.410 Does each referral from an...

  17. 20 CFR 411.410 - Does each referral from an EN to a State VR agency require its own agreement?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Does each referral from an EN to a State VR agency require its own agreement? 411.410 Section 411.410 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.410 Does each referral from an...

  18. 20 CFR 411.405 - When does an agreement between an EN and the State VR agency have to be in place?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false When does an agreement between an EN and the State VR agency have to be in place? 411.405 Section 411.405 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.405 When does an agreement...

  19. 20 CFR 411.405 - When does an agreement between an EN and the State VR agency have to be in place?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false When does an agreement between an EN and the State VR agency have to be in place? 411.405 Section 411.405 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.405 When does an agreement...

  20. 20 CFR 411.405 - When does an agreement between an EN and the State VR agency have to be in place?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false When does an agreement between an EN and the State VR agency have to be in place? 411.405 Section 411.405 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.405 When does an agreement...

  1. 2 CFR 382.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Officials § 382.400 What method do I use as an agency awarding official to obtain a recipient's agreement to... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 382.400 Section 382.400 Grants...

  2. 2 CFR 782.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Officials § 782.400 What method do I use as an agency awarding official to obtain a recipient's agreement to... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 782.400 Section 782.400 Grants...

  3. 2 CFR 902.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ....400 What method do I use as an agency awarding official to obtain a recipient's agreement to comply... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 902.400 Section 902.400 Grants...

  4. 2 CFR 421.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ....400 What method do I use as an agency awarding official to obtain a recipient's agreement to comply... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 421.400 Section 421.400 Grants...

  5. 2 CFR 421.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ....400 What method do I use as an agency awarding official to obtain a recipient's agreement to comply... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 421.400 Section 421.400 Grants...

  6. 2 CFR 382.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Officials § 382.400 What method do I use as an agency awarding official to obtain a recipient's agreement to... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 382.400 Section 382.400 Grants...

  7. 2 CFR 782.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Officials § 782.400 What method do I use as an agency awarding official to obtain a recipient's agreement to... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 782.400 Section 782.400 Grants...

  8. 2 CFR 2339.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... § 2339.400 What method do I use as an agency awarding official to obtain a recipient's agreement to... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 2339.400 Section 2339.400...

  9. 2 CFR 2339.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... § 2339.400 What method do I use as an agency awarding official to obtain a recipient's agreement to... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 2339.400 Section 2339.400...

  10. 2 CFR 902.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ....400 What method do I use as an agency awarding official to obtain a recipient's agreement to comply... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 902.400 Section 902.400 Grants...

  11. 2 CFR 782.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Officials § 782.400 What method do I use as an agency awarding official to obtain a recipient's agreement to... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 782.400 Section 782.400 Grants...

  12. 2 CFR 2339.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... § 2339.400 What method do I use as an agency awarding official to obtain a recipient's agreement to... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 2339.400 Section 2339.400...

  13. 2 CFR 902.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ....400 What method do I use as an agency awarding official to obtain a recipient's agreement to comply... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 902.400 Section 902.400 Grants...

  14. 2 CFR 421.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ....400 What method do I use as an agency awarding official to obtain a recipient's agreement to comply... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 421.400 Section 421.400 Grants...

  15. 2 CFR 2339.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... § 2339.400 What method do I use as an agency awarding official to obtain a recipient's agreement to... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 2339.400 Section 2339.400...

  16. 2 CFR 382.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Officials § 382.400 What method do I use as an agency awarding official to obtain a recipient's agreement to... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 382.400 Section 382.400 Grants...

  17. 2 CFR 902.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ....400 What method do I use as an agency awarding official to obtain a recipient's agreement to comply... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 902.400 Section 902.400 Grants...

  18. 78 FR 20658 - Agency Information Collection Activities; Proposed Collection; Comment Request; Agreement for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... Devices for Sterilization AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and... of information technology. Agreement for Shipment of Devices for Sterilization--21 CFR 801.150(e... commerce for sterilization at another establishment, a practice that facilitates the processing of devices...

  19. 2 CFR 382.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Officials § 382.400 What method do I use as an agency awarding official to obtain a recipient's agreement to... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 382.400 Section 382.400 Grants...

  20. 21 CFR 20.108 - Agreements between the Food and Drug Administration and other departments, agencies, and...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Specific Categories of Records § 20.108 Agreements between the Food and Drug Administration and other... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Agreements between the Food and Drug Administration and other departments, agencies, and organizations. 20.108 Section 20.108 Food and Drugs FOOD AND...

  1. 20 CFR 411.420 - What information should be included in an agreement between an EN and a State VR agency?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false What information should be included in an agreement between an EN and a State VR agency? 411.420 Section 411.420 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.420 What information should be...

  2. 20 CFR 411.420 - What information should be included in an agreement between an EN and a State VR agency?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false What information should be included in an agreement between an EN and a State VR agency? 411.420 Section 411.420 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.420 What information should be...

  3. 20 CFR 411.420 - What information should be included in an agreement between an EN and a State VR agency?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false What information should be included in an agreement between an EN and a State VR agency? 411.420 Section 411.420 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.420 What information should be...

  4. Miscellaneous agreements between the U.S. Department of Energy and Federal, State, and local agencies.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Meincke, Carol L.

    This document identifies and provides access to source documentation for the Site- Wide Environmental Impact Statement for Sandia National Laboratories/New Mexico. Specifically, it lists agreements between the U.S. Department of Energy (DOE), the National Nuclear Security Administration (NNSA), DOE/NNSA/Sandia Site Office (SSO), Sandia Corporation, and local and state government agencies, Department of Defense, Kirtland Air Force Base, and other federal agencies.

  5. Measurement of the ratios of branching fractions B(B0s --> Ds- pi+ pi+ pi-)/B(B0-->D- pi+ pi+ pi-) and B(B0s --> Ds- pi+)/B(B0-->D- pi+).

    PubMed

    Abulencia, A; Adelman, J; Affolder, T; Akimoto, T; Albrow, M G; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J-F; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, G; Bellinger, J; Belloni, A; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Budroni, S; Burkett, K; Busetto, G; Bussey, P; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carillo, S; Carlsmith, D; Carosi, R; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciljak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; Cyr, D; DaRonco, S; D'Auria, S; Davies, T; D'Onofrio, M; Dagenhart, D; de Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; Dell'Orso, M; Delli Paoli, F; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; Dituro, P; Dörr, C; Donati, S; Donega, M; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Field, R; Flanagan, G; Foland, A; Forrester, S; Foster, G W; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garcia, J E; Garberson, F; Garfinkel, A F; Gay, C; Gerberich, H; Gerdes, D; Giagu, S; Giannetti, P; Gibson, A; Gibson, K; Gimmell, J L; Ginsburg, C; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, J; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Griffiths, M; Grinstein, S; Grosso-Pilcher, C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B-Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Holloway, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ishizawa, Y; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jensen, H; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kovalev, A; Kraan, A C; Kraus, J; Kravchenko, I; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhlmann, S E; Kuhr, T; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; LeCompte, T; Lee, J; Lee, J; Lee, Y J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Loverre, P; Lu, R-S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maki, T; Maksimovic, P; Malde, S; Manca, G; Margaroli, F; Marginean, R; Marino, C; Marino, C P; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Mastrandrea, P; Masubuchi, T; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miles, J; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyamoto, A; Moed, S; Moggi, N; Mohr, B; Moore, R; Morello, M; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Mumford, R; Murat, P; Nachtman, J; Nagano, A; Naganoma, J; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nigmanov, T; Nodulman, L; Norniella, O; Nurse, E; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Oldeman, R; Orava, R; Osterberg, K; Pagliarone, C; Palencia, E; Papadimitriou, V; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ranjan, N; Rappoccio, S; Reisert, B; Rekovic, V; Renton, P; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Sabik, S; Safonov, A; Sakumoto, W K; Salamanna, G; Saltó, O; Saltzberg, D; Sánchez, C; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyrla, A; Shapiro, M D; Shears, T; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakyan, A; Sjolin, J; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Spreitzer, T; Squillacioti, P; Stanitzki, M; Staveris-Polykalas, A; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sun, H; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Takikawa, K; Tanaka, M; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tsuchiya, R; Tsuno, S; Turini, N; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vallecorsa, S; van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Veramendi, G; Veszpremi, V; Vidal, R; Vila, I; Vilar, R; Vine, T; Vollrath, I; Volobouev, I; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner, J; Wagner, W; Wallny, R; Wang, S M; Warburton, A; Waschke, S; Waters, D; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zhou, J; Zucchelli, S

    2007-02-09

    Using 355 pb;{-1} of data collected by the CDF II detector in pp[over ] collisions at sqrt[s]=1.96 TeV at the Fermilab Tevatron, we study the fully reconstructed hadronic decays B_{(s)};{0}-->D_{(s)};{-}pi;{+} and B_{(s)};{0}-->D_{(s)};{-}pi;{+}pi;{+}pi;{-}. We present the first measurement of the ratio of branching fractions B(B_{s};{0}-->D_{s};{-}pi;{+}pi;{+}pi;{-})/B(B;{0}-->D;{-}pi;{+}pi;{+}pi;{-})=1.05+/-0.10(stat)+/-0.22(syst). We also update our measurement of B(B_{s};{0}-->D_{s};{-}pi;{+})/B(B;{0}-->D;{-}pi;{+}) to 1.13+/-0.08(stat)+/-0.23(syst), improving the statistical uncertainty by more than a factor of 2. We find B(B_{s};{0}-->D_{s};{-}pi;{+})=[3.8+/-0.3(stat)+/-1.3(syst)]x10;{-3} and B(B_{s};{0}-->D_{s};{-}pi;{+}pi;{+}pi;{-})=[8.4+/-0.8(stat)+/-3.2(syst)]x10;{-3}.

  6. 2 CFR 3373.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Officials § 3373.400 What method do I use as an agency awarding official to obtain a recipient's agreement... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false What method do I use as an agency awarding...

  7. 2 CFR 3373.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Officials § 3373.400 What method do I use as an agency awarding official to obtain a recipient's agreement... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false What method do I use as an agency awarding...

  8. 2 CFR 1536.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Officials § 1536.400 What method do I use as an agency awarding official to obtain a recipient's agreement... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false What method do I use as an agency awarding...

  9. 2 CFR 3001.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Officials § 3001.400 What method do I use as an agency awarding official to obtain a recipient's agreement... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false What method do I use as an agency awarding...

  10. 2 CFR 1536.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Officials § 1536.400 What method do I use as an agency awarding official to obtain a recipient's agreement... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false What method do I use as an agency awarding...

  11. 2 CFR 1536.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Officials § 1536.400 What method do I use as an agency awarding official to obtain a recipient's agreement... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false What method do I use as an agency awarding...

  12. 2 CFR 3001.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Officials § 3001.400 What method do I use as an agency awarding official to obtain a recipient's agreement... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false What method do I use as an agency awarding...

  13. 2 CFR 1536.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Officials § 1536.400 What method do I use as an agency awarding official to obtain a recipient's agreement... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false What method do I use as an agency awarding...

  14. 2 CFR 3373.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Officials § 3373.400 What method do I use as an agency awarding official to obtain a recipient's agreement... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false What method do I use as an agency awarding...

  15. 2 CFR 3373.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Officials § 3373.400 What method do I use as an agency awarding official to obtain a recipient's agreement... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false What method do I use as an agency awarding...

  16. 2 CFR 3001.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Officials § 3001.400 What method do I use as an agency awarding official to obtain a recipient's agreement... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false What method do I use as an agency awarding...

  17. Dynamical coupled-channels study of pi N --> pi pi N reactions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kamano, Hiroyuki; Julia Diaz, Bruno; Lee, Tsung-Shung

    2009-01-01

    As a step toward performing a complete coupled-channels analysis of the world data of pi N, gamma^* N --> pi N, eta N, pi pi N reactions, the pi N --> pi pi N reactions are investigated starting with the dynamical coupled-channels model developed in Phys. Rev. C76, 065201 (2007). The channels included are pi N, eta N, and pi pi N which has pi Delta, rho N, and sigma N resonant components. The non-resonant amplitudes are generated from solving a set of coupled-channels equations with the meson-baryon potentials defined by effective Lagrangians. The resonant amplitudes are generated from 16more » bare excited nucleon (N^*) states which are dressed by the non-resonant interactions as constrained by the unitarity condition. The available total cross section data of pi^+ p --> pi^+ pi^+ n, pi^+ pi^0 and pi^- p --> pi^+ pi^- n, pi^- pi^0 n, pi^0 pi^0 n can be reproduced to a very large extent both in magnitudes and energy-dependence. Possible improvements of the model are investigated, in p« less

  18. 75 FR 78807 - Agency Information Collection (Other On-The-Job Training and Apprenticeship Training Agreement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-16

    ... Officer, OMB Human Resources and Housing Branch, New Executive Office Building, Room 10235, Washington, DC...-The-Job Training and Apprenticeship Training Agreement and Standards and Employer's Application To Provide Job Training) Activity Under OMB Review AGENCY: Veterans Benefits Administration, Department of...

  19. Observation of {eta}{sup '} Decays to {pi}{sup +}{pi}{sup -}{pi}{sup 0} and {pi}{sup +}{pi}{sup -}e{sup +}e{sup -}

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Naik, P.; Rademacker, J.; Asner, D. M.

    Using {psi}(2S){yields}{pi}{sup +}{pi}{sup -}J/{psi}, J/{psi}{yields}{gamma}{eta}{sup '} events acquired with the CLEO-c detector at the CESR e{sup +}e{sup -} collider, we make the first observations of the decays {eta}{sup '}{yields}{pi}{sup +}{pi}{sup -}{pi}{sup 0} and {eta}{sup '}{yields}{pi}{sup +}{pi}{sup -}e{sup +}e{sup -}, measuring absolute branching fractions (37{sub -9}{sup +11}{+-}4)x10{sup -4} and (25{sub -9}{sup +12}{+-}5)x10{sup -4}, respectively. For {eta}{sup '}{yields}{pi}{sup +}{pi}{sup -}{pi}{sup 0}, this result probes the mechanism of isospin violation and the roles of {pi}{sup 0}/{eta}/{eta}{sup '}-mixing and final state rescattering in strong decays. We also set upper limits on branching fractions for {eta}{sup '} decays to {pi}{sup +}{pi}{sup -}{mu}{sup +}{mu}{sup -}, 2({pi}{supmore » +}{pi}{sup -}), {pi}{sup +}{pi}{sup -}2{pi}{sup 0}, 2({pi}{sup +}{pi}{sup -}){pi}{sup 0}, 3({pi}{sup +}{pi}{sup -}), and invisible final states.« less

  20. 2 CFR 1401.245 - Federal agency or agency.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Federal agency or agency. 1401.245 Section 1401.245 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF THE INTERIOR REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) (Eff. 1-21-2011) Definitions § 1401...

  1. 75 FR 5099 - Agency Information Collection Activities: Visa Waiver Program Carrier Agreement (Form I-775)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... Activities: Visa Waiver Program Carrier Agreement (Form I-775) AGENCY: U.S. Customs and Border Protection... and Budget (OMB) for review and approval in accordance with the Paperwork Reduction Act: Visa Waiver... other technological techniques or other forms of information. Title: Visa Waiver Program Carrier...

  2. Measurement of CP Asymmetries and Branching Fractions in B0 -> pi+ pi-, B0 -> K+ pi-, B0 -> pi0 pi0, B0 -> K0 pi0 and Isospin Analysis of B -> pi pi Decays

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aubert, Bernard; Bona, M.; Karyotakis, Y.

    2008-08-01

    The authors present preliminary results of improved measurements of the CP-violating asymmetries and branching fractions in the decays B{sup 0} {yields} {pi}{sup +}{pi}{sup -}, B{sup 0} {yields} K{sup +}{pi}{sup -}, B{sup 0} {yields} {pi}{sup 0}{pi}{sup 0}, and B{sup 0} {yields} K{sup 0}{pi}{sup 0}. This update includes all data taken at the {Upsilon}(4S) resonance by the BABAR experiment at the asymmetric PEP-II B-meson factory at SLAC, corresponding to 467 {+-} 5 million B{bar B} pairs. They find S{sub {pi}{pi}} = -0.68 {+-} 0.10 {+-} 0.03, C{sub {pi}{pi}} = -0.25 {+-} 0.08 {+-} 0.02, {Alpha}{sub K{sub {pi}}} = -0.107 {+-} 0.016{sub -0.004},{supmore » +0.006}, C{sub {pi}{sup 0}{pi}{sup 0}} = -0.43 {+-} 0.26 {+-} 0.05, {Beta}(B{sup 0} {yields} {pi}{sup 0}{pi}{sup 0}) = (1.83 {+-} 0.21 {+-} 0.13) x 10{sup -6}, {Beta}(B{sup 0} {yields} K{sup 0}{pi}{sup 0}) = (10.1 {+-} 0.6 {+-} 0.4) x 10{sup -6}, where the first error is statistical and the second is systematic. They observe CP violation with a significance of 6.7{sigma} in B{sup 0} {yields} {pi}{sup -} and 6.1{sigma} in B{sup 0} {yields} K{sup +}{pi}{sup -}. Constraints on the Unitarity Triangle angle {alpha} are determined from the isospin relation between all B {yields} {pi}{pi} rates and asymmetries.« less

  3. Scalar resonances in a unitary {pi}{pi} S-wave model for D{sup +}{yields}{pi}{sup +}{pi}{sup -}{pi}{sup +}

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Boito, D. R.; Instituto de Fisica, Universidade de Sao Paulo, C.P. 66318, 05315-970, Sao Paulo, SP; Dedonder, J.-P.

    We propose a model for D{sup +}{yields}{pi}{sup +}{pi}{sup -}{pi}{sup +} decays following experimental results which indicate that the two-pion interaction in the S wave is dominated by the scalar resonances f{sub 0}(600)/{sigma} and f{sub 0}(980). The weak decay amplitude for D{sup +}{yields}R{pi}{sup +}, where R is a resonance that subsequently decays into {pi}{sup +}{pi}{sup -}, is constructed in a factorization approach. In the S wave, we implement the strong decay R{yields}{pi}{sup +}{pi}{sup -} by means of a scalar form factor. This provides a unitary description of the pion-pion interaction in the entire kinematically allowed mass range m{sub {pi}}{sub {pi}}{sup 2}more » from threshold to about 3 GeV{sup 2}. In order to reproduce the experimental Dalitz plot for D{sup +}{yields}{pi}{sup +}{pi}{sup -}{pi}{sup +}, we include contributions beyond the S wave. For the P wave, dominated by the {rho}(770){sup 0}, we use a Breit-Wigner description. Higher waves are accounted for by using the usual isobar prescription for the f{sub 2}(1270) and {rho}(1450){sup 0}. The major achievement is a good reproduction of the experimental m{sub {pi}}{sub {pi}}{sup 2} distribution, and of the partial as well as the total D{sup +}{yields}{pi}{sup +}{pi}{sup -}{pi}{sup +} branching ratios. Our values are generally smaller than the experimental ones. We discuss this shortcoming and, as a by-product, we predict a value for the poorly known D{yields}{sigma} transition form factor at q{sup 2}=m{sub {pi}}{sup 2}.« less

  4. Determination of the S-Wave Pi Pi Scattering Lengths From a Study of K - to Pi - Pi0 Pi0 Decays

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Batley, J.R.; Culling, A.J.; Kalmus, G.

    We report the results from a study of the full sample of {approx}6.031 x 10{sup 7} K{sup {+-}} {yields} {pi}{sup {+-}}{pi}{sup 0}{pi}{sup 0} decays recorded by the NA48/2 experiment at the CERN SPS. As first observed in this experiment, the {pi}{sup 0}{pi}{sup 0} invariant mass (M{sub 00}) distribution shows a cusp-like anomaly in the region around M{sub 00} = 2m{sub +}, where m{sub +} is the charged pion mass. This anomaly has been interpreted as an effect due mainly to the final state charge exchange scattering process {pi}{sup +}{pi}{sup -} {yields} {pi}{sup 0}{pi}{sup 0} in K{sup {+-}} {yields} {pi}{sup {+-}}{pi}{supmore » +}{pi}{sup -} decay. Fits to the M{sub 00} distribution using two different theoretical formulations provide the presently most precise determination of a{sub 0} - a{sub 2}, the difference between the {pi}{pi} S-wave scattering lengths in the isospin I = 0 and I = 2 states. Higher-order {pi}{pi} rescattering terms, included in the two formulations, allow also an independent, though less precise, determination of a{sub 2}.« less

  5. Dynamical coupled-channels study of {pi}N{yields}{pi}{pi}N reactions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kamano, H.; Julia-Diaz, B.; Department d'Estructura i Constituents de la Materia and Institut de Ciencies del Cosmos, Universitat de Barcelona E-08028 Barcelona

    As a step toward performing a complete coupled-channels analysis of the world data of {pi}N,{gamma}*N{yields}{pi}N,{eta}N,{pi}{pi}N reactions, the {pi}N{yields}{pi}{pi}N reactions are investigated starting with the dynamical coupled-channels model developed in Phys. Rev. C 76, 065201 (2007). The channels included are {pi}N,{eta}N, and {pi}{pi}N which has {pi}{delta},{rho}N, and {sigma}N resonant components. The nonresonant amplitudes are generated from solving a set of coupled-channels equations with the meson-baryon potentials defined by effective Lagrangians. The resonant amplitudes are generated from 16 bare excited nucleon (N*) states that are dressed by the nonresonant interactions as constrained by the unitarity condition. The data of total cross sectionsmore » and {pi}N and {pi}{pi} invariant mass distributions of {pi}{sup +}p{yields}{pi}{sup +}{pi}{sup +}n,{pi}{sup +}{pi}{sup 0}p and {pi}{sup -}p{yields}{pi}{sup +}{pi}{sup -}n,{pi}{sup -}{pi}{sup 0}p,{pi}{sup 0}{pi}{sup 0}n reactions from threshold to the invariant mass W=2 GeV can be described to a very large extent. We show the importance of the coupled-channels effects and the strong interference among the contributions from the {pi}{delta},{sigma}N, and {rho}N channels. The large interference between the resonant and nonresonant amplitudes is also demonstrated. Possible future developments are discussed.« less

  6. PiVoT GPS Receiver

    NASA Technical Reports Server (NTRS)

    Wennersten, Miriam Dvorak; Banes, Anthony Vince; Boegner, Gregory J.; Dougherty, Lamar; Edwards, Bernard L.; Roman, Joseph; Bauer, Frank H. (Technical Monitor)

    2001-01-01

    NASA Goddard Space Flight Center has built an open architecture, 24 channel space flight GPS receiver. The CompactPCI PiVoT GPS receiver card is based on the Mitel/GEC Plessey Builder-2 board. PiVoT uses two Plessey 2021 correlators to allow tracking of up to 24 separate GPS SV's on unique channels. Its four front ends can support four independent antennas, making it a useful card for hosting GPS attitude determination algorithms. It has been built using space quality, radiation tolerant parts. The PiVoT card will track a weaker signal than the original Builder 2 board. It also hosts an improved clock oscillator. The PiVoT software is based on the original Plessey Builder 2 software ported to the Linux operating system. The software is POSIX complaint and can easily be converted to other POSIX operating systems. The software is open source to anyone with a licensing agreement with Plessey. Additional tasks can be added to the software to support GPS science experiments or attitude determination algorithms. The next generation PiVoT receiver will be a single radiation hardened CompactPCI card containing the microprocessor and the GPS receiver optimized for use above the GPS constellation. PiVoT was flown successfully on a balloon in July, 2001, for its first non-simulated flight.

  7. 75 FR 36654 - Proposed Settlement Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9168-9] Proposed Settlement Agreement AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of Proposed Settlement Agreement; request for public comment. SUMMARY.... 7413(g), notice is hereby given of a proposed settlement agreement to address lawsuits filed by...

  8. 75 FR 82390 - Proposed Settlement Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-30

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9246-2] Proposed Settlement Agreement AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of Proposed Settlement Agreement; Request for Public Comment. SUMMARY... a proposed settlement agreement to address lawsuits filed by the following groups of Petitioners: (1...

  9. 75 FR 82009 - Proposed Settlement Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9245-1] Proposed Settlement Agreement AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of Proposed Settlement Agreement; Request for Public Comment. SUMMARY... a proposed settlement agreement to address a lawsuit filed by the Center for Biological Diversity...

  10. 78 FR 59684 - Proposed Settlement Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-27

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9901-48-OGC] Proposed Settlement Agreement AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of proposed settlement agreement; request for public... hereby given of a proposed settlement agreement to address a lawsuit filed by the American Forest & Paper...

  11. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Agreements. 247.4 Section 247.4 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are necessary for agencies to administer CSFP? The following agreements are necessary for agencies to administer...

  12. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Agreements. 247.4 Section 247.4 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are necessary for agencies to administer CSFP? The following agreements are necessary for agencies to administer...

  13. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Agreements. 247.4 Section 247.4 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are necessary for agencies to administer CSFP? The following agreements are necessary for agencies to administer...

  14. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Agreements. 247.4 Section 247.4 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are necessary for agencies to administer CSFP? The following agreements are necessary for agencies to administer...

  15. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Agreements. 247.4 Section 247.4 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are necessary for agencies to administer CSFP? The following agreements are necessary for agencies to administer...

  16. The e{sup +}e{sup -}{yields}2({pi}{sup +}{pi}{sup -}){pi}{sup 0}, 2({pi}{sup +}{pi}{sup -}){eta}, K{sup +}K{sup -}{pi}{sup +}{pi}{sup -}{pi}{sup 0} and K{sup +}K{sup -}{pi}{sup +}{pi}{sup -}{eta} cross sections measured with initial-state radiation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aubert, B.; Bona, M.; Boutigny, D.

    We study the processes e{sup +}e{sup -}{yields}2({pi}{sup +}{pi}{sup -}){pi}{sup 0}{gamma}, 2({pi}{sup +}{pi}{sup -}){eta}{gamma}, K{sup +}K{sup -}{pi}{sup +}{pi}{sup -}{pi}{sup 0}{gamma} and K{sup +}K{sup -}{pi}{sup +}{pi}{sup -}{eta}{gamma} with the hard photon radiated from the initial state. About 20 000, 4300, 5500, and 375 fully reconstructed events, respectively, are selected from 232 fb{sup -1} of BABAR data. The invariant mass of the hadronic final state defines the effective e{sup +}e{sup -} center-of-mass energy, so that the obtained cross sections from the threshold to about 5 GeV can be compared with corresponding direct e{sup +}e{sup -} measurements, currently available only for the {eta}{pi}{sup +}{pi}{supmore » -} and {omega}{pi}{sup +}{pi}{sup -} submodes of the e{sup +}e{sup -}{yields}2({pi}{sup +}{pi}{sup -}){pi}{sup 0} channel. Studying the structure of these events, we find contributions from a number of intermediate states, and we extract their cross sections where possible. In particular, we isolate the contribution from e{sup +}e{sup -}{yields}{omega}(782){pi}{sup +}{pi}{sup -} and study the {omega}(1420) and {omega}(1650) resonances. In the charmonium region, we observe the J/{psi} in all these final states and several intermediate states, as well as the {psi}(2S) in some modes, and we measure the corresponding branching fractions.« less

  17. 76 FR 67728 - Proposed Settlement Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9485-8] Proposed Settlement Agreement AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of proposed settlement agreement; request for public comment. SUMMARY...), notice is hereby given of a proposed settlement agreement to address a lawsuit filed by the Engine...

  18. 76 FR 56194 - Proposed Settlement Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-12

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9462-9] Proposed Settlement Agreement AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of Proposed Settlement Agreement; Request for Public Comment. SUMMARY...), notice is hereby given of a proposed settlement agreement to address a lawsuit filed by Allied Energy...

  19. Standardized Reporting of Prostate MRI: Comparison of the Prostate Imaging Reporting and Data System (PI-RADS) Version 1 and Version 2

    PubMed Central

    Tewes, Susanne; Mokov, Nikolaj; Hartung, Dagmar; Schick, Volker; Peters, Inga; Schedl, Peter; Pertschy, Stefanie; Wacker, Frank; Voshage, Götz; Hueper, Katja

    2016-01-01

    Introduction Objective of our study was to determine the agreement between version 1 (v1) and v2 of the Prostate Imaging Reporting and Data System (PI-RADS) for evaluation of multiparametric prostate MRI (mpMRI) and to compare their diagnostic accuracy, their inter-observer agreement and practicability. Material and Methods mpMRI including T2-weighted imaging, diffusion-weighted imaging (DWI) and dynamic contrast-enhanced imaging (DCE) of 54 consecutive patients, who subsequently underwent MRI-guided in-bore biopsy were re-analyzed according to PI-RADS v1 and v2 by two independent readers. Diagnostic accuracy for detection of prostate cancer (PCa) was assessed using ROC-curve analysis. Agreement between PI-RADS versions and observers was calculated and the time needed for scoring was determined. Results MRI-guided biopsy revealed PCa in 31 patients. Diagnostic accuracy for detection of PCa was equivalent with both PI-RADS versions for reader 1 with sensitivities and specificities of 84%/91% (AUC = 0.91 95%CI[0.8–1]) for PI-RADS v1 and 100%/74% (AUC = 0.92 95% CI[0.8–1]) for PI-RADS v2. Reader 2 achieved similar diagnostic accuracy with sensitivity and specificity of 74%/91% (AUC = 0.88 95%CI[0.8–1]) for PI-RADS v1 and 81%/91% (AUC = 0.91 95%CI[0.8–1]) for PI-RADS v2. Agreement between scores determined with different PI-RADS versions was good (reader 1: κ = 0.62, reader 2: κ = 0.64). Inter-observer agreement was moderate with PI-RADS v2 (κ = 0.56) and fair with v1 (κ = 0.39). The time required for building the PI-RADS score was significantly lower with PI-RADS v2 compared to v1 (24.7±2.3 s vs. 41.9±2.6 s, p<0.001). Conclusion Agreement between PI-RADS versions was high and both versions revealed high diagnostic accuracy for detection of PCa. Due to better inter-observer agreement for malignant lesions and less time demand, the new PI-RADS version could be more practicable for clinical routine. PMID:27657729

  20. Scalar resonances in a unitary {pi}{pi} S-wave model for D{sup +} {r_arrow} {pi}{sup+}{pi}{sup-}{pi}{sup+}.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Boito, D. R.; Dedonder, J.-P.; El-Bennich, B.

    We propose a model for D{sup +} {yields} {pi}{sup +}{pi}{sup -}{pi}{sup +} decays following experimental results which indicate that the two-pion interaction in the S wave is dominated by the scalar resonances f{sub 0}(600)/{sigma} and f{sub 0}(980). The weak decay amplitude for D{sup +} {yields} R{pi}{sup +}, where R is a resonance that subsequently decays into {pi}{sup +}{pi}{sup -}, is constructed in a factorization approach. In the S wave, we implement the strong decay R {yields} {pi}{sup +}{pi}{sup -} by means of a scalar form factor. This provides a unitary description of the pion-pion interaction in the entire kinematically allowedmore » mass range m{sub {pi}{pi}}{sup 2} from threshold to about 3 GeV{sup 2}. In order to reproduce the experimental Dalitz plot for D{sup +} {yields} {pi}{sup +}{pi}{sup -}{pi}{sup +}, we include contributions beyond the S wave. For the P wave, dominated by the {rho}(770){sup 0}, we use a Breit-Wigner description. Higher waves are accounted for by using the usual isobar prescription for the f{sub 2}(1270) and {rho}(1450){sup 0}. The major achievement is a good reproduction of the experimental m{sub {pi}{pi}}{sup 2} distribution, and of the partial as well as the total D{sup +} {yields} {pi}{sup +}{pi}{sup -}{pi}{sup +} branching ratios. Our values are generally smaller than the experimental ones. We discuss this shortcoming and, as a by-product, we predict a value for the poorly known D {yields} {sigma} transition form factor at q{sup 2} = m{sub {pi}}{sup 2}.« less

  1. 46 CFR 308.548 - Standard form of underwriting agency agreement for cargo, Form MA-318.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., Form MA-318. 308.548 Section 308.548 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iv-General § 308.548 Standard form of underwriting agency agreement for cargo, Form MA-318. This form, which may be obtained from the American War...

  2. 46 CFR 308.551 - War risk insurance clearing agency agreement for cargo, Form MA-321.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false War risk insurance clearing agency agreement for cargo, Form MA-321. 308.551 Section 308.551 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iv-General § 308.551 War risk insurance...

  3. 46 CFR 308.551 - War risk insurance clearing agency agreement for cargo, Form MA-321.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false War risk insurance clearing agency agreement for cargo, Form MA-321. 308.551 Section 308.551 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance General § 308.551 War risk insurance...

  4. 46 CFR 308.548 - Standard form of underwriting agency agreement for cargo, Form MA-318.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., Form MA-318. 308.548 Section 308.548 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iv-General § 308.548 Standard form of underwriting agency agreement for cargo, Form MA-318. This form, which may be obtained from the American War...

  5. 46 CFR 308.551 - War risk insurance clearing agency agreement for cargo, Form MA-321.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false War risk insurance clearing agency agreement for cargo, Form MA-321. 308.551 Section 308.551 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iv-General § 308.551 War risk insurance...

  6. 46 CFR 308.548 - Standard form of underwriting agency agreement for cargo, Form MA-318.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., Form MA-318. 308.548 Section 308.548 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iv-General § 308.548 Standard form of underwriting agency agreement for cargo, Form MA-318. This form, which may be obtained from the American War...

  7. 46 CFR 308.548 - Standard form of underwriting agency agreement for cargo, Form MA-318.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., Form MA-318. 308.548 Section 308.548 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iv-General § 308.548 Standard form of underwriting agency agreement for cargo, Form MA-318. This form, which may be obtained from the American War...

  8. 46 CFR 308.551 - War risk insurance clearing agency agreement for cargo, Form MA-321.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false War risk insurance clearing agency agreement for cargo, Form MA-321. 308.551 Section 308.551 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iv-General § 308.551 War risk insurance...

  9. 46 CFR 308.551 - War risk insurance clearing agency agreement for cargo, Form MA-321.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false War risk insurance clearing agency agreement for cargo, Form MA-321. 308.551 Section 308.551 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iv-General § 308.551 War risk insurance...

  10. PiVoT GPS Receiver

    NASA Technical Reports Server (NTRS)

    Wennersten, Miriam; Banes, Vince; Boegner, Greg; Clagnett, Charles; Dougherty, Lamar; Edwards, Bernard; Roman, Joe; Bauer, Frank H. (Technical Monitor)

    2001-01-01

    NASA Goddard Space Flight Center has built an open architecture, 24 channel spaceflight Global Positioning System (GPS) receiver. The compact PCI PiVoT GPS receiver card is based on the Mitel/GEC Plessey Builder 2 board. PiVoT uses two Plessey 2021 correlators to allow tracking of up to 24 separate GPS SV's on unique channels. Its four front ends can support four independent antennas, making it a useful card for hosting GPS attitude determination algorithms. It has been built using space quality, radiation tolerant parts. The PiVoT card works at a lower signal to noise ratio than the original Builder 2 board. It also hosts an improved clock oscillator. The PiVoT software is based on the original Piessey Builder 2 software ported to the Linux operating system. The software is posix compliant and can be easily converted to other posix operating systems. The software is open source to anyone with a licensing agreement with Plessey. Additional tasks can be added to the software to support GPS science experiments or attitude determination algorithms. The next generation PiVoT receiver will be a single radiation hardened compact PCI card containing the microprocessor and the GPS receiver optimized for use above the GPS constellation.

  11. 48 CFR 42.002 - Interagency agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Interagency agreements. 42... MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES 42.002 Interagency agreements. (a) Agencies shall avoid... agency, through the use of interagency agreements. (b) Subject to the fiscal regulations of the agencies...

  12. 48 CFR 42.002 - Interagency agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Interagency agreements. 42... MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES 42.002 Interagency agreements. (a) Agencies shall avoid... agency, through the use of interagency agreements. (b) Subject to the fiscal regulations of the agencies...

  13. 48 CFR 42.002 - Interagency agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Interagency agreements. 42... MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES 42.002 Interagency agreements. (a) Agencies shall avoid... agency, through the use of interagency agreements. (b) Subject to the fiscal regulations of the agencies...

  14. Dynamical coupled-channels study of {pi}N {right arrow} {pi pi}N reactions.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kamano, H.; Julia-Diaz, B.; Lee, T.-S. H.

    As a step toward performing a complete coupled-channels analysis of the world data of {pi}N,{gamma}*N {yields} {pi}N,{eta}N,{pi}{pi}N reactions, the {pi}N {yields} {pi}{pi}N reactions are investigated starting with the dynamical coupled-channels model developed in Phys. Rev. C 76, 065201 (2007). The channels included are {pi}N,{eta}N, and {pi}{pi}N which has {pi}{Delta},{rho}N, and {sigma}N resonant components. The nonresonant amplitudes are generated from solving a set of coupled-channels equations with the meson-baryon potentials defined by effective Lagrangians. The resonant amplitudes are generated from 16 bare excited nucleon (N*) states that are dressed by the nonresonant interactions as constrained by the unitarity condition. The datamore » of total cross sections and {pi}N and {pi}{pi} invariant mass distributions of {pi} + p {yields} {pi} + {pi} + n, {pi} + {pi}0p and {pi} - p {yields} {pi} + {pi} - n, {pi} - {pi}0p,{pi}0{pi}0n reactions from threshold to the invariant mass W = 2 GeV can be described to a very large extent. We show the importance of the coupled-channels effects and the strong interference among the contributions from the {pi}{Delta},{sigma}N, and {rho}N channels. The large interference between the resonant and nonresonant amplitudes is also demonstrated. Possible future developments are discussed.« less

  15. 77 FR 39511 - Solicitation for a Cooperative Agreement: Development of a Guide for Correctional Agencies To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ... inform the development of televisiting initiatives. The cooperative agreement awardee will design and... design and develop three products: (1) A guide to assist correctional agencies in the establishment of... to make enhancements to current televisiting initiatives, (3) a series of evaluative questions about...

  16. 2 CFR 182.645 - Federal agency or agency.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Federal agency or agency. 182.645 Section 182.645 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions...

  17. 48 CFR 41.206 - Interagency agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Interagency agreements. 41... agreements. Agencies shall use interagency agreements (e.g., consolidated purchase, joint use, or cross-service agreements) when acquiring utility service or facilities from other Government agencies and shall...

  18. 48 CFR 41.206 - Interagency agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Interagency agreements. 41... agreements. Agencies shall use interagency agreements (e.g., consolidated purchase, joint use, or cross-service agreements) when acquiring utility service or facilities from other Government agencies and shall...

  19. 48 CFR 41.206 - Interagency agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Interagency agreements. 41... agreements. Agencies shall use interagency agreements (e.g., consolidated purchase, joint use, or cross-service agreements) when acquiring utility service or facilities from other Government agencies and shall...

  20. Measurements of the branching fractions for B{sub (s)}{yields}D{sub (s)}{pi}{pi}{pi} and {Lambda}{sub b}{sup 0}{yields}{Lambda}{sub c}{sup +}{pi}{pi}{pi}

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aaij, R.; Bauer, Th.; Beuzekom, M. van

    Branching fractions of the decays H{sub b}{yields}H{sub c}{pi}{sup -}{pi}{sup +}{pi}{sup -} relative to H{sub b}{yields}H{sub c}{pi}{sup -} are presented, where H{sub b} (H{sub c}) represents B{sup 0} (D{sup +}), B{sup -} (D{sup 0}), B{sub s}{sup 0} (D{sub s}{sup +}), and {Lambda}{sub b}{sup 0} ({Lambda}{sub c}{sup +}). The measurements are performed with the LHCb detector using 35 pb{sup -1} of data collected at {radical}(s)=7 TeV. The ratios of branching fractions are measured to be [B(B{sup 0}{yields}D{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -})]/[B(B{sup 0}{yields}D{sup +}{pi}{sup -})]=2.38{+-}0.11{+-}0.21, [B(B{sup -}{yields}D{sup 0}{pi}{sup -}{pi}{sup +}{pi}{sup -})]/[B(B{sup -}{yields}D{sup 0}{pi}{sup -})]= 1.27{+-}0.06{+-}0.11, [B(B{sub s}{sup 0}{yields}D{sub s}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -})]/[B(B{submore » s}{sup 0}{yields}D{sub s}{sup +}{pi}{sup -})]=2.01{+-}0.37{+-}0.20, [B({Lambda}{sub b}{sup 0}{yields}{Lambda}{sub c}{sup +}{pi}{sup -} {pi}{sup +}{pi}{sup -})]/[B({Lambda}{sub b}{sup 0}{yields}{Lambda}{sub c}{sup +}{pi}{sup -})]=1.43{+-}0.16{+-}0.13 We also report measurements of partial decay rates of these decays to excited charm hadrons. These results are of comparable or higher precision than existing measurements.« less

  1. 77 FR 7242 - Agency Information Collection (Agreement To Train on the Job Disabled Veterans): Activity Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-10

    ..., OMB Human Resources and Housing Branch, New Executive Office Building, Room 10235, Washington, DC... (Agreement To Train on the Job Disabled Veterans): Activity Under OMB Review AGENCY: Veterans Benefits... to the Office of Management and Budget (OMB) for review and comment. The PRA submission describes the...

  2. 20 CFR 411.435 - How will disputes arising under the agreements between ENs and State VR agencies be resolved?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM State Vocational Rehabilitation Agencies' Participation Resolving Disputes Arising Under Agreements Between Employment Networks and State...

  3. 20 CFR 411.435 - How will disputes arising under the agreements between ENs and State VR agencies be resolved?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM State Vocational Rehabilitation Agencies' Participation Resolving Disputes Arising Under Agreements Between Employment Networks and State...

  4. 20 CFR 411.435 - How will disputes arising under the agreements between ENs and State VR agencies be resolved?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM State Vocational Rehabilitation Agencies' Participation Resolving Disputes Arising Under Agreements Between Employment Networks and State...

  5. Role of the N*(1535) resonance and the {pi}{sup -}p{yields}KY amplitudes in the OZI forbidden {pi}N{yields}{phi}N reaction

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Doering, M.; Oset, E.; Zou, B. S.

    2008-08-15

    We study the {pi}N{yields}{phi}N reaction close to the {phi}N threshold within the chiral unitary approach, by combining the {pi}{sup -}p{yields}K{sup +}{sigma}{sup -},{pi}{sup -}p{yields}K{sup 0}{sigma}{sup 0}, and {pi}{sup -}p{yields}K{sup 0}{lambda} amplitudes with the coupling of {phi} to the K components of the final states of these reactions via quantum loops. We obtain good agreement with experiment when the dominant {pi}{sup -}p{yields}K{sup 0}{lambda} amplitude is constrained with its experimental cross section. We also evaluate the coupling of N*(1535) to {phi}N and find a moderate coupling as a consequence of partial cancellation of the large KY components of N*(1535). We also show thatmore » the N*(1535) pole approximation is too small to reproduce the measured cross section for the {pi}{sup -}N{yields}{phi}N reaction.« less

  6. Effect of unitarization on the amplitudes for the decays K{sub 1}{sup 0} {sup {yields} {pi}+{pi}-} and K{sup +} {sup {yields} {pi}+{pi}+{pi}-}

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shabalin, E. P., E-mail: shabalin@itep.r

    The unitarization of the amplitude for the decay process K{sub 1}{sup 0} {sup {yields} {pi}+{pi}-} and allowance for the rescattering of final-state pions in the decay process K{sup +} {sup {yields} {pi}+{pi}+{pi}-} make it possible to evaluate, by using the parameters extracted from data on K {sup {yields}}2{pi} decays, the K{sup +} {sup {yields} {pi}+{pi}+{pi}-} decay width. The result agrees with the experimental width value at a level of a few percent. Allowance for corrections for higher order terms of the momentum expansion of the amplitude for the decay process K{sup +} {sup {yields} {pi}+{pi}+{pi}-} leads to the slope-parameter valuemore » of g{sub ++-}{sup th} = 0.2182, which agrees with its experimental counterpart, g{sub ++-}{sup exp} = 0.2154 {+-} 0.0035.« less

  7. First observation of the decays {chi}{sub cJ}{yields}{pi}{sup 0}{pi}{sup 0}{pi}{sup 0}{pi}{sup 0}

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ablikim, M.; An, Z. H.; Bai, J. Z.

    We present a study of the P-wave spin-triplet charmonium {chi}{sub cJ} decays (J=0, 1, 2) into {pi}{sup 0}{pi}{sup 0}{pi}{sup 0}{pi}{sup 0}. The analysis is based on 106x10{sup 6} {psi}{sup '} decays recorded with the BESIII detector at the BEPCII electron positron collider. The decay into the {pi}{sup 0}{pi}{sup 0}{pi}{sup 0}{pi}{sup 0} hadronic final state is observed for the first time. We measure the branching fractions B({chi}{sub c0}{yields}{pi}{sup 0}{pi}{sup 0}{pi}{sup 0}{pi}{sup 0})=(3.34{+-}0.06{+-}0.44)x10{sup -3}, B({chi}{sub c1}{yields}{pi}{sup 0}{pi}{sup 0}{pi}{sup 0}{pi}{sup 0})=(0.57{+-}0.03{+-}0.08)x10{sup -3}, and B({chi}{sub c2}{yields}{pi}{sup 0}{pi}{sup 0}{pi}{sup 0}{pi}{sup 0})=(1.21{+-}0.05{+-}0.16)x10{sup -3}, where the uncertainties are statistical and systematical, respectively.

  8. Study of the strong {sigma}{sub c}{yields}{lambda}{sub c}{pi},{sigma}{sub c}*{yields}{lambda}{sub c}{pi} and {xi}{sub c}*{yields}{xi}{sub c}{pi} decays in a nonrelativistic quark model

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Albertus, C.; Nieves, J.; Hernandez, E.

    We present results for the strong widths corresponding to the {sigma}{sub c}{yields}{lambda}{sub c}{pi}, {sigma}{sub c}*{yields}{lambda}{sub c}{pi} and {xi}{sub c}*{yields}{xi}{sub c}{pi} decays. The calculations have been done in a nonrelativistic constituent quark model with wave functions that take advantage of the constraints imposed by heavy quark symmetry. Partial conservation of axial current hypothesis allows us to determine the strong vertices from an analysis of the axial current matrix elements. Our results {gamma}({sigma}{sub c}{sup ++}{yields}{lambda}{sub c}{sup +}{pi}{sup +})=2.41{+-}0.07{+-}0.02 MeV, {gamma}({sigma}{sub c}{sup +}{yields}{lambda}{sub c}{sup +}{pi}{sup 0})=2.79{+-}0.08{+-}0.02 MeV, {gamma}({sigma}{sub c}{sup 0}{yields}{lambda}{sub c}{sup +}{pi}{sup -})=2.37{+-}0.07{+-}0.02 MeV, {gamma}({sigma}{sub c}*{sup ++}{yields}{lambda}{sub c}{sup +}{pi}{sup +})=17.52{+-}0.74{+-}0.12 MeV, {gamma}({sigma}{sub c}*{supmore » +}{yields}{lambda}{sub c}{sup +}{pi}{sup 0})=17.31{+-}0.73{+-}0.12 MeV, {gamma}({sigma}{sub c}*{sup 0}{yields}{lambda}{sub c}{sup +}{pi}{sup -})=16.90{+-}0.71{+-}0.12 MeV, {gamma}({xi}{sub c}*{sup +}{yields}{xi}{sub c}{sup 0}{pi}{sup +}+{xi}{sub c}{sup +}{pi}{sup 0})=3.18{+-}0.10{+-}0.01 MeV, and {gamma}({xi}{sub c}*{sup 0}{yields}{xi}{sub c}{sup +}{pi}{sup -}+{xi}{sub c}{sup 0}{pi}{sup 0})=3.03{+-}0.10{+-}0.01 MeV are in good agreement with experimental determinations.« less

  9. 76 FR 16850 - 60-Day Notice of Proposed Information Collection: Agency Form DS-4127, NEA/PI Online Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... Form DS- 4127, NEA/PI Online Performance Reporting System (PRS), OMB Control Number 1405-0183. ACTION... Collection: NEA/PI Online Performance Reporting System (PRS). OMB Control Number: 1405-0183. Type of Request: Renewal. Originating Office: NEA/PI. Form Number: DS-4127. Respondents: Recipients of NEA/PI grants...

  10. Measurement of CP--violating asymmetries in $$D^0\\to\\pi^+\\pi^-$$ and $$D^0\\to K^+K^-$$ decays at CDF

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aaltonen, T.; /Helsinki Inst. of Phys.; Alvarez Gonzalez, B.

    2011-11-01

    We report on a measurement of CP-violating asymmetries (A{sub CP}) in the Cabibbo-suppressed D{sup 0} {yields} {pi}{sup +}{pi}{sup -} and D{sup 0} {yields} K{sup +}K{sup -} decays reconstructed in a data sample corresponding to 5.9 fb{sup -1} of integrated luminosity collected by the upgraded Collider Detector at Fermilab. We use the strong decay D*{sup +} {yields} D{sup 0}{pi}{sup +} to identify the flavor of the charmed meson at production and exploit CP-conserving strong c{bar c} pair-production in p{bar p} collisions. High-statistics samples of Cabibbo-favored D{sup 0} {yields} K{sup -}{pi}{sup +} decays with and without a D*{sup {+-}} tag are usedmore » to correct for instrumental effects and significantly reduce systematic uncertainties. We measure A{sub CP}(D{sup 0} {yields} {pi}{sup +}{pi}{sup -}) = (+0.22 {+-} 0.24(stat) {+-} 0.11 (syst))% and A{sub CP}(D{sup 0} {yields} K{sup +}K{sup -}) = (-0.24 {+-} 0.22 (stat) {+-} 0.09 (syst))%, in agreement with CP conservation. These are the most precise determinations from a single experiment to date. Under the assumption of negligible direct CP violation in D{sup 0} {yields} {pi}{sup +}{pi}{sup -} and D{sup 0} {yields} K{sup +}K{sup -} decays, the results provide an upper limit to the CP-violating asymmetry in D{sup 0} mixing, |A{sub CP}{sup ind}(D{sup 0})| < 0.13% at the 90% confidence level.« less

  11. 2 CFR 382.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... condition in the award: Drug-free workplace. You as the recipient must comply with drug-free workplace... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false What method do I use as an agency awarding official to obtain a recipient's agreement to comply with the OMB guidance? 382.400 Section 382.400 Grants...

  12. 2 CFR 2245.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Awarding Officials § 2245.400 What method do I use as an agency awarding official to obtain a recipient's... of the award, to comply with the requirements in subpart B (or subpart C, if the recipient is an... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false What method do I use as an agency awarding...

  13. 2 CFR 3186.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Awarding Officials § 3186.400 What method do I use as an agency awarding official to obtain a recipient's... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false What method do I use as an agency awarding...

  14. 2 CFR 3186.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Awarding Officials § 3186.400 What method do I use as an agency awarding official to obtain a recipient's... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false What method do I use as an agency awarding...

  15. 2 CFR 3186.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Awarding Officials § 3186.400 What method do I use as an agency awarding official to obtain a recipient's... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false What method do I use as an agency awarding...

  16. 2 CFR 2245.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Awarding Officials § 2245.400 What method do I use as an agency awarding official to obtain a recipient's... of the award, to comply with the requirements in subpart B (or subpart C, if the recipient is an... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false What method do I use as an agency awarding...

  17. 2 CFR 2429.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Awarding Officials § 2429.400 What method do I use as an agency awarding official to obtain a recipient's... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false What method do I use as an agency awarding...

  18. 2 CFR 3186.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Awarding Officials § 3186.400 What method do I use as an agency awarding official to obtain a recipient's... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false What method do I use as an agency awarding...

  19. 2 CFR 2429.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Awarding Officials § 2429.400 What method do I use as an agency awarding official to obtain a recipient's... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false What method do I use as an agency awarding...

  20. 2 CFR 2429.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Awarding Officials § 2429.400 What method do I use as an agency awarding official to obtain a recipient's... award: Drug-free workplace. You as the recipient must comply with drug-free workplace requirements in... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false What method do I use as an agency awarding...

  1. 2 CFR 2245.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Awarding Officials § 2245.400 What method do I use as an agency awarding official to obtain a recipient's... of the award, to comply with the requirements in subpart B (or subpart C, if the recipient is an... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false What method do I use as an agency awarding...

  2. 2 CFR 2245.400 - What method do I use as an agency awarding official to obtain a recipient's agreement to comply...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Awarding Officials § 2245.400 What method do I use as an agency awarding official to obtain a recipient's... of the award, to comply with the requirements in subpart B (or subpart C, if the recipient is an... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false What method do I use as an agency awarding...

  3. 7 CFR 766.201 - Shared Appreciation Agreement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Recovery Buyout Agreements § 766.201 Shared Appreciation Agreement. (a) When a SAA is required. The Agency... loans; (3) The borrower ceases farming; or (4) The Agency accelerates the borrower's loans. ...

  4. 7 CFR 766.201 - Shared Appreciation Agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Recovery Buyout Agreements § 766.201 Shared Appreciation Agreement. (a) When a SAA is required. The Agency... loans; (3) The borrower ceases farming; or (4) The Agency accelerates the borrower's loans. ...

  5. 7 CFR 766.201 - Shared Appreciation Agreement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Recovery Buyout Agreements § 766.201 Shared Appreciation Agreement. (a) When a SAA is required. The Agency... loans; (3) The borrower ceases farming; or (4) The Agency accelerates the borrower's loans. ...

  6. 7 CFR 766.201 - Shared Appreciation Agreement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Recovery Buyout Agreements § 766.201 Shared Appreciation Agreement. (a) When a SAA is required. The Agency... loans; (3) The borrower ceases farming; or (4) The Agency accelerates the borrower's loans. ...

  7. 7 CFR 766.201 - Shared Appreciation Agreement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Recovery Buyout Agreements § 766.201 Shared Appreciation Agreement. (a) When a SAA is required. The Agency... loans; (3) The borrower ceases farming; or (4) The Agency accelerates the borrower's loans. ...

  8. Multiparametric MRI of the prostate: diagnostic performance and interreader agreement of two scoring systems.

    PubMed

    Lin, Wei-Ching; Muglia, Valdair F; Silva, Gyl E B; Chodraui Filho, Salomão; Reis, Rodolfo B; Westphalen, Antonio C

    2016-06-01

    To compare the diagnostic accuracies and interreader agreements of the Prostate Imaging Reporting and Data System (PI-RADS) v. 2 and University of California San Francisco (UCSF) multiparametric prostate MRI scale for diagnosing clinically significant prostate cancer. This institutional review board-approved retrospective study included 49 males who had 1.5 T endorectal MRI and prostatectomy. Two radiologists scored suspicious lesions on MRI using PI-RADS v. 2 and the UCSF scale. Percent agreement, 2 × 2 tables and the area under the receiver operating characteristic curves (Az) were used to assess and compare the individual and overall scores of these scales. Interreader agreements were estimated with kappa statistics. Reader 1 (R1) detected 78 lesions, and Reader 2 (R2) detected 80 lesions. Both identified 52 of 65 significant cancers. The Az for PI-RADS v. 2 and UCSF scale for R1 were 0.68 and 0.69 [T2 weighted imaging (T2WI)], 0.75 and 0.68 [diffusion-weighted imaging (DWI)] and 0.64 and 0.72 (overall score), respectively, and were 0.72 and 0.75 (T2WI), 0.73 and 0.67 (DWI) and 0.66 and 0.75 (overall score) for R2. The dynamic contrast-enhanced percent agreements between scales were 100% (R1) and 95% (R2). PI-RADS v. 2 DWI of R1 performed better than UCSF DWI (Az = 0.75 vs Az = 0.68; p = 0.05); no other differences were found. The interreader agreements were higher for PI-RADS v. 2 (T2WI: 0.56 vs 0.42; DWI: 0.60 vs 0.46; overall: 0.61 vs 0.42). The UCSF approach to derive the overall PI-RADS v. 2 scores increased the Az for the identification of significant cancer (R1 to 0.76, p < 0.05; R2 to 0.71, p = 0.35). Although PI-RADS v. 2 DWI score may have a higher discriminatory performance than the UCSF scale counterpart to diagnose clinically significant cancer, the utilization of the UCSF scale weighing system for the integration of PI-RADS v. 2 individual parameter scores improved the accuracy its overall score. PI-RADS v. 2 is

  9. Study of the K{sup +}{pi}{sup +}{pi}{sup -} final state in B{sup +}{yields}J/{psi}K{sup +}{pi}{sup +}{pi}{sup -} and B{sup +}{yields}{psi}'K{sup +}{pi}{sup +}{pi}{sup -}

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Guler, H.; McGill University, Montreal; Universite de Montreal, Montreal

    Using 535x10{sup 6} B-meson pairs collected by the Belle detector at the KEKB e{sup +}e{sup -} collider, we measure branching fractions of (7.16{+-}0.10(stat){+-}0.60(syst)x10{sup -4} for B{sup +}{yields}J/{psi}K{sup +}{pi}{sup +}{pi}{sup -} and (4.31{+-}0.20(stat){+-}0.50(syst))x10{sup -4} for B{sup +}{yields}{psi}'K{sup +}{pi}{sup +}{pi}{sup -}. We perform amplitude analyses to determine the resonant structure of the K{sup +}{pi}{sup +}{pi}{sup -} final state in B{sup +}{yields}J/{psi}K{sup +}{pi}{sup +}{pi}{sup -} and B{sup +}{yields}{psi}'K{sup +}{pi}{sup +}{pi}{sup -} and find that the K{sub 1}(1270) is a prominent component of both decay modes. There is significant interference among the different intermediate states, which leads, in particular, to a striking distortion ofmore » the {rho} line shape due to the {omega}. Based on the results of the fit to the B{sup +}{yields}J/{psi}K{sup +}{pi}{sup +}{pi}{sup -} data, the relative decay fractions of the K{sub 1}(1270) to K{rho}, K{omega}, and K*(892){pi} are consistent with previous measurements, but the decay fraction to K{sub 0}*(1430) is significantly smaller. Finally, by floating the mass and width of the K{sub 1}(1270) in an additional fit of the B{sup +}{yields}J/{psi}K{sup +}{pi}{sup +}{pi}{sup -} data, we measure a mass of (1248.1{+-}3.3(stat){+-}1.4(syst)) MeV/c{sup 2} and a width of (119.5{+-}5.2(stat){+-}6.7(syst)) MeV/c{sup 2} for the K{sub 1}(1270).« less

  10. NASA and Russian Space Agency sign agreement for additional Space Shuttle/Mir missions

    PubMed

    Huff, W

    1994-01-01

    On December 16, 1993 NASA Administrator Daniel S. Goldin [correction of Golden] and the Russian Space Agency (RSA) director Yuri Koptev signed a protocol agreeing to up to 10 Shuttle flights to Mir with a total of 24 months time aboard Mir for U.S. astronants, a program of scientific and technological research, and the upgrade and extension of the Mir lifetime during the period 1995-1997. This is the first of a three-phase program in human spaceflight cooperation which may culminate in the construction of an international Space Station. This agreement starts joint development of spacecraft environmental control and life support systems and potential common space suit.

  11. Phosphate (Pi)-regulated heterodimerization of the high-affinity sodium-dependent Pi transporters PiT1/Slc20a1 and PiT2/Slc20a2 underlies extracellular Pi sensing independently of Pi uptake.

    PubMed

    Bon, Nina; Couasnay, Greig; Bourgine, Annabelle; Sourice, Sophie; Beck-Cormier, Sarah; Guicheux, Jérôme; Beck, Laurent

    2018-02-09

    Extracellular phosphate (P i ) can act as a signaling molecule that directly alters gene expression and cellular physiology. The ability of cells or organisms to detect changes in extracellular P i levels implies the existence of a P i -sensing mechanism that signals to the body or individual cell. However, unlike in prokaryotes, yeasts, and plants, the molecular players involved in P i sensing in mammals remain unknown. In this study, we investigated the involvement of the high-affinity, sodium-dependent P i transporters PiT1 and PiT2 in mediating P i signaling in skeletal cells. We found that deletion of PiT1 or PiT2 blunted the P i -dependent ERK1/2-mediated phosphorylation and subsequent gene up-regulation of the mineralization inhibitors matrix Gla protein and osteopontin. This result suggested that both PiTs are necessary for P i signaling. Moreover, the ERK1/2 phosphorylation could be rescued by overexpressing P i transport-deficient PiT mutants. Using cross-linking and bioluminescence resonance energy transfer approaches, we found that PiT1 and PiT2 form high-abundance homodimers and P i -regulated low-abundance heterodimers. Interestingly, in the absence of sodium-dependent P i transport activity, the PiT1-PiT2 heterodimerization was still regulated by extracellular P i levels. Of note, when two putative P i -binding residues, Ser-128 (in PiT1) and Ser-113 (in PiT2), were substituted with alanine, the PiT1-PiT2 heterodimerization was no longer regulated by extracellular P i These observations suggested that P i binding rather than P i uptake may be the key factor in mediating P i signaling through the PiT proteins. Taken together, these results demonstrate that P i -regulated PiT1-PiT2 heterodimerization mediates P i sensing independently of P i uptake. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

  12. Reaction. pi. /sup -/p. --> pi. /sup -/. pi. /sup +/. pi. /sup -/p at 8 GeV/c

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kitagaki, T.; Tanaka, S.; Yuta, H.

    1982-10-01

    Results from a high-statistics experiment involving an exposure of the SLAC 82-in. hydrogen bubble chamber to a beam of 8-GeV/c ..pi../sup -/ yielding a final state of ..pi../sup -/..pi../sup +/..pi../sup -/p are presented. Copious production of rho, ..delta../sup + +/, and f is found. Considerable quasi-two-body production in which one particle decays to one of the above resonances is also observed. Some double-resonance production involving baryon and meson resonances is also seen. The production properties of rho, ..delta../sup + +/, and f mesons are well described by a double-Regge model.

  13. Exclusive Central pi+pi- production in CDF

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Albrow, Michael; Swiech, Artur; Zurek, Maria

    2013-10-14

    Using the Collider Detector at Fermilab, CDF, we have measured exclusive pi+pi- production at sqrt(s) = 900 GeV and 1960 GeV. The pi+pi- pair is central, |y| < 1.0, and there are no other particles detected in |eta| < 5.9. We discuss the mass spectrum, showing f0(980) and f2(1270) resonances, s-dependence, pT-dependence, and angular distributions.

  14. First Observation of the Cabibbo-suppressed Decays Xi+(c) ---> Sigma+ pi- pi+ and Xi+(c) ---> Sigma- pi+ pi+ and Measurement of their Branching Ratios

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vazquez-Jauregui, E.; /San Luis Potosi U.; Engelfried, J.

    The authors report the first observation of two Cabibbo-suppressed decay modes, {Xi}{sub c}{sup +} {yields} {Sigma}{sup +}{pi}{sup -}{pi}{sup +} and {Xi}{sub c}{sup +} {yields} {Sigma}{sup -} {pi}{sup +}{pi}{sup +}. They observe 56 {+-} 13 over a background of 21, and 23 {+-} 7 over a background of 12 events, respectively, for the signals. The data were accumulated using the SELEX spectrometer during the 1996-1997 fixed target run at Fermilab, chiefly from a 600 GeV/c {Sigma}{sup -} beam. The branching ratios of the decays relative to the Cabibbo-favored {Xi}{sub c}{sup +} {yields} {Xi}{sup -}{pi}{sup +}{pi}{sup +} are measured to be B({Xi}{submore » c}{sup +} {yields} {Sigma}{sup +}{pi}{sup -}{pi}{sup +})/B({xi}{sub c}{sup +} {yields} {Xi}{sup -} {pi}{sup +}{pi}{sup +}) = 0.50 {+-} 0.20, and B({Xi}{sub c}{sup +} {yields} {Sigma}{sup -}{pi}{sup +}{pi}{sup +})/B({Xi}{sub c}{sup +} {yields} {Xi}{sup -}{pi}{sup +}{pi}{sup +}) = 0.23 {+-} 0.11, respectively. They also report branching ratios for the same decay modes of the {Lambda}{sub c}{sup +} relative to {Lambda}{sub c}{sup +} {yields} pK{sup -}{pi}{sup +}.« less

  15. 2 CFR 3001.661 - Reimbursable Agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Reimbursable Agreement. 3001.661 Section 3001.661 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF... Reimbursable Agreement. Reimbursable Agreement means an award in which the recipient is reimbursed for...

  16. Large electroweak penguin contribution in B{yields}K{pi} and {pi}{pi} decay modes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mishima, Satoshi; Yoshikawa, Tadashi

    2004-11-01

    We discuss a possibility of large electroweak penguin contribution in B{yields}K{pi} and {pi}{pi} from recent experimental data. The experimental data may be suggesting that there are some discrepancies between the data and theoretical estimation in the branching ratios of them. In B{yields}K{pi} decays, to explain it, a large electroweak penguin contribution and large strong phase differences seem to be needed. The contributions should appear also in B{yields}{pi}{pi}. We show, as an example, a solution to solve the discrepancies in both B{yields}K{pi} and B{yields}{pi}{pi}. However the magnitude of the parameters and the strong phase estimated from experimental data are quite largemore » compared with the theoretical estimations. It may be suggesting some new physics effects are included in these processes. We will have to discuss about the dependence of the new physics. To explain both modes at once, we may need large electroweak penguin contribution with new weak phases and some SU(3) breaking effects by new physics in both QCD and electroweak penguin-type processes.« less

  17. Measurement of the branching fraction $${\\mathcal{B}}(\\Lambda^0_b\\rightarrow \\Lambda^+_c\\pi^-\\pi^+\\pi^-)$$ at CDF

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aaltonen, T.; /Helsinki Inst. of Phys.; Alvarez Gonzalez, B.

    We report an analysis of the {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -} decay in a data sample collected by the CDF II detector at the Fermilab Tevatron corresponding to 2.4 fb{sup -1} of integrated luminosity. We reconstruct the currently largest samples of the decay modes {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}(2595){sup +}{pi}{sup -} (with {Lambda}{sub c}(2595){sup +} {yields} {Lambda}{sub c}{sup +}{pi}{sup +}{pi}{sup -}), {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}(2625){sup +}{pi}{sup -} (with {Lambda}{sub c}(2625){sup +} {yields} {Lambda}{sub c}{sup +}{pi}{sup +}{pi}{sup -}), {Lambda}{sub b}{sup 0} {yields} {Sigma}{sub c}(2455){sup ++}{pi}{sup -}{pi}{sup -} (with {Sigma}{sub c}(2455){sup ++} {yields} {Lambda}{submore » c}{sup +}{pi}{sup +}), and {Lambda}{sub b}{sup 0} {yields} {Sigma}{sub c}(2455)0{pi}{sup +}{pi}{sup -} (with {Sigma}{sub c}(2455)0 {yields} {Lambda}{sub c}{sup +}{pi}{sup -}) and measure the branching fractions relative to the {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}{sup +}{pi}{sup -} branching fraction. We measure the ratio {Beta}({Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -})/ {Beta}({Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}{sup +}{pi}{sup -})=3.04 {+-} 0.33(stat){sub -0.55}{sup +0.70}(syst) which is used to derive {Beta}({Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -})=(26.8{sub -11.2}{sup +11.9}) x 10{sup -3}.« less

  18. First observation and measurement of the resonant structure of the lambda_b->lambda_c pi-pi+pi- decay mode

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Azzurri, P.; Barria, P.; Ciocci, M.A.

    The authors present the first observation of the {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -} decay using data from an integrated luminosity of approximately 2.4 fb{sup -1} of p{bar p} collisions at {radical}s = 1.96 TeV, collected with the CDF II detector at the Fermilab Tevatron. They also present the first observation of the resonant decays {Lambda}{sub b}{sup 0} {yields} {Sigma}{sub c}(2455){sup 0} {pi}{sup +}{pi}{sup -} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -}, {Lambda}{sub b}{sup 0} {yields} {Sigma}{sub c}(2455){sup ++}{pi}{sup -}{pi}{sup -} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -}, {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}(2595){sup +}{pi}{sup -}more » {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -} and {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}(2625){sup +}{pi}{sup -} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -}, and measure their relative branching ratios.« less

  19. The Parity of the Neutral Pion and the Decay pi{sup 0} Yields 2e{sup +} + 2e{sup -}

    DOE R&D Accomplishments Database

    Samios, N. P.; Plano, R.; Prodell, A.; Schwartz, M.; Steinberger, J.

    1962-01-01

    Two hundred and six electronic decays of the pi{sup 0}, pi{sup 0} yields e{sup +} + e{sup -} + e{sup +} + e{sup -}, were observed in a hydrogen bubble chamber. The decay distributions of the electron pairs and the total rate for this process are shown to be in good agreement with theory. An examination of correlations of the e{sup +}e{sup -} pair decay planes on the basis of electrodynamic predictions is in agreement with the hypothesis that the pi{sup 0} is pseudoscalar, but disagrees for scalar pions by 3.6 standard deviations. (auth)

  20. The PI-Mode of Project Management

    NASA Technical Reports Server (NTRS)

    Isaac, Dan

    1997-01-01

    The PI-Mode is NASA's new approach to project management. It responds to the Agency's new policy to develop scientific missions that deliver the highest quality science for a fixed cost. It also attempts to provide more research opportunities by reducing project development times and increasing the number of launches per year. In order to accomplish this, the Principal Investigator is placed at the helm of the project with full responsibility over all aspects of the mission, including instrument and spacecraft development, as well as mission operations and data analysis. This paper intends to study the PI-Mode to determine the strengths and weaknesses of such a new project management technique. It also presents an analysis of its possible impact on the scientific community and its relations with industry, NASA, and other institutions.

  1. Exotic and qq-bar resonances in the pi+pi-pi- system produced in pi-p collisions at 18 GeV/c

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    S. U. Chung; K. Danyo; R. W. Hackenburg

    A partial-wave analysis of the reaction pi{sup -}p-->pi{sup +}pi{sup -}pi{sup -}p at 18 GeV/c has been performed on a data sample of 250 000 events obtained in the Brookhaven experiment E852. The well-known a{sub 1}(1260), a{sub 2}(1320) and pi{sub 2}(1670) resonant states are observed. The existence of the pi(1800), a{sub 1}(1700) and a{sub 4}(2040) states is confirmed. The a{sub 3}(1874) state is also observed. The exotic 1{sup -+} pi{sub 1}(1600) state produced in the natural parity exchange process is found to decay in the rho(770)pi{sup -} channel. A mass-dependent fit results in a resonance mass of 1593{+-}8{sub -47}{sup +29} MeV/c{supmore » 2} and a width of 168{+-}20{sub -12}{sup +150} MeV/c{sup 2}.« less

  2. 2 CFR 1401.220 - Cooperative agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Cooperative agreement. 1401.220 Section 1401.220 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF THE... agreement. Cooperative agreement means an award of financial assistance that, consistent with 31 U.S.C. 6305...

  3. The utility of the NEO-PI-R validity scales to detect response distortion: a comparison with the MMPI-2.

    PubMed

    Morasco, Benjamin J; Gfeller, Jeffrey D; Elder, Katherine A

    2007-06-01

    In this psychometric study, we compared the recently developed Validity Scales from the Revised NEO Personality Inventory (NEO PI-R; Costa & McCrae, 1992b) with the MMPI-2 (Butcher, Dahstrom, Graham, Tellegen, & Kaemmer, 1989) Validity Scales. We collected data from clients (n = 74) who completed comprehensive psychological evaluations at a university-based outpatient mental health clinic. Correlations between the Validity Scales of the NEO-PI-R and MMPI-2 were significant and in the expected directions. The relationships provide support for convergent and discriminant validity of the NEO-PI-R Validity Scales. The percent agreement of invalid responding on the two measures was high, although the diagnostic agreement was modest (kappa = .22-.33). Finally, clients who responded in an invalid manner on the NEO-PI-R Validity Scales produced significantly different clinical profiles on the NEO-PI-R and MMPI-2 than clients with valid protocols. These results provide additional support for the clinical utility of the NEO-PI-R Validity Scales as indicators of response bias.

  4. Chiral symmetry and N*(1440){yields}N{pi}{pi} decay

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kamano, H.; Morishita, M.; Arima, M.

    2005-04-01

    The N*(1440){yields}N{pi}{pi} decay is studied by making use of the chiral reduction formula. This formula suggests a scalar-isoscalar pion-baryon contact interaction that is absent in the recent study of Hernandez et al. [Phys. Rev. C 66, 065201 (2002)]. The contact interaction is introduced into their model and is found to be necessary for the simultaneous description of g{sub RN{pi}}{sub {pi}} and the {pi}{pi} and {pi}N invariant mass distributions.

  5. 7 CFR 1782.19 - Third party agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Director may authorize third party operation, maintenance, and management of an Agency financed facility. The borrower's attorney must review the contract, management agreement, written lease, or other third party agreement and issue an opinion to the Agency as to their legal sufficiency. The borrower shall...

  6. 29 CFR 1908.10 - Cooperative Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 5 2012-07-01 2012-07-01 false Cooperative Agreements. 1908.10 Section 1908.10 Labor... CONSULTATION AGREEMENTS § 1908.10 Cooperative Agreements. (a) Who may make Agreements. The Assistant Secretary may make a Cooperative Agreement under this part with the Governor of a State or with any State agency...

  7. 29 CFR 1908.10 - Cooperative Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false Cooperative Agreements. 1908.10 Section 1908.10 Labor... CONSULTATION AGREEMENTS § 1908.10 Cooperative Agreements. (a) Who may make Agreements. The Assistant Secretary may make a Cooperative Agreement under this part with the Governor of a State or with any State agency...

  8. 29 CFR 1908.10 - Cooperative Agreements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 5 2014-07-01 2014-07-01 false Cooperative Agreements. 1908.10 Section 1908.10 Labor... CONSULTATION AGREEMENTS § 1908.10 Cooperative Agreements. (a) Who may make Agreements. The Assistant Secretary may make a Cooperative Agreement under this part with the Governor of a State or with any State agency...

  9. 48 CFR 16.702 - Basic agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Basic agreements. 16.702... AND CONTRACT TYPES TYPES OF CONTRACTS Agreements 16.702 Basic agreements. (a) Description. A basic agreement is a written instrument of understanding, negotiated between an agency or contracting activity and...

  10. 48 CFR 16.702 - Basic agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Basic agreements. 16.702... AND CONTRACT TYPES TYPES OF CONTRACTS Agreements 16.702 Basic agreements. (a) Description. A basic agreement is a written instrument of understanding, negotiated between an agency or contracting activity and...

  11. 48 CFR 16.702 - Basic agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Basic agreements. 16.702... AND CONTRACT TYPES TYPES OF CONTRACTS Agreements 16.702 Basic agreements. (a) Description. A basic agreement is a written instrument of understanding, negotiated between an agency or contracting activity and...

  12. 2 CFR 1401.220 - Cooperative agreement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Cooperative agreement. 1401.220 Section 1401.220 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF THE INTERIOR REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) (Eff. 1-21-2011) Definitions § 1401...

  13. 40 CFR 35.3010 - Delegation agreement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Delegation agreement. 35.3010 Section... agreement. (a) Before execution of the delegation agreement, the Regional Administrator must determine that the unit of the State agency designated to implement the agreement is capable of carrying out the...

  14. 40 CFR 35.3010 - Delegation agreement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Delegation agreement. 35.3010 Section... agreement. (a) Before execution of the delegation agreement, the Regional Administrator must determine that the unit of the State agency designated to implement the agreement is capable of carrying out the...

  15. 7 CFR 634.15 - Agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Agreements. 634.15 Section 634.15 Agriculture... Agreements. The State Conservationist, NRCS, upon receiving notice of an approved project, is to enter into a grant agreement with the administering agency, except in those cases where USDA is to administer the...

  16. 7 CFR 634.15 - Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Agreements. 634.15 Section 634.15 Agriculture... Agreements. The State Conservationist, NRCS, upon receiving notice of an approved project, is to enter into a grant agreement with the administering agency, except in those cases where USDA is to administer the...

  17. 7 CFR 634.15 - Agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Agreements. 634.15 Section 634.15 Agriculture... Agreements. The State Conservationist, NRCS, upon receiving notice of an approved project, is to enter into a grant agreement with the administering agency, except in those cases where USDA is to administer the...

  18. 7 CFR 634.15 - Agreements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Agreements. 634.15 Section 634.15 Agriculture... Agreements. The State Conservationist, NRCS, upon receiving notice of an approved project, is to enter into a grant agreement with the administering agency, except in those cases where USDA is to administer the...

  19. 7 CFR 634.15 - Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Agreements. 634.15 Section 634.15 Agriculture... Agreements. The State Conservationist, NRCS, upon receiving notice of an approved project, is to enter into a grant agreement with the administering agency, except in those cases where USDA is to administer the...

  20. Experimental Study of the NaK 3(1)Pi State.

    PubMed

    Laub; Mazsa; Webb; La Civita J; Prodan; Jabbour; Namiotka; Huennekens

    1999-02-01

    We report the results of an optical-optical double resonance experiment to determine the NaK 3(1)Pi state potential energy curve. In the first step, a narrow band cw dye laser (PUMP) is tuned to line center of a particular 2(A)1Sigma+(v', J') <-- 1(X)1Sigma+(v", J") transition, and its frequency is then fixed. A second narrowband tunable cw Ti:Sapphirelaser (PROBE) is then scanned, while 3(1)Pi --> 1(X)1Sigma+ violet fluorescence is monitored. The Doppler-free signals accurately map the 3(1)Pi(v, J) ro-vibrational energy levels. These energy levels are then fit to a Dunham expansion to provide a set of molecular constants. The Dunham constants, in turn, are used to construct an RKR potential curve. Resolved 3(1)Pi(v, J) --> 1(X)1Sigma+(v", J") fluorescence scans are also recorded with both PUMP and PROBE laser frequencies fixed. Comparison between observed and calculated Franck-Condon factors is used to determine the absolute vibrational numbering of the 3(1)Pi state levels and to determine the variation of the 3(1)Pi --> 1(X)1Sigma+ transitiondipole moment with internuclear separation. The recent theoretical calculation of the NaK 3(1)Pi state potential reported by Magnier and Millié (1996, Phys. Rev. A 54, 204) is in excellent agreement with the present experimental RKR curve. Copyright 1999 Academic Press.

  1. Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing

    PubMed Central

    Le Thomas, Adrien; Stuwe, Evelyn; Li, Sisi; Marinov, Georgi; Rozhkov, Nikolay; Chen, Yung-Chia Ariel; Luo, Yicheng; Sachidanandam, Ravi; Toth, Katalin Fejes; Patel, Dinshaw; Aravin, Alexei A.

    2014-01-01

    Small noncoding RNAs that associate with Piwi proteins, called piRNAs, serve as guides for repression of diverse transposable elements in germ cells of metazoa. In Drosophila, the genomic regions that give rise to piRNAs, the so-called piRNA clusters, are transcribed to generate long precursor molecules that are processed into mature piRNAs. How genomic regions that give rise to piRNA precursor transcripts are differentiated from the rest of the genome and how these transcripts are specifically channeled into the piRNA biogenesis pathway are not known. We found that transgenerationally inherited piRNAs provide the critical trigger for piRNA production from homologous genomic regions in the next generation by two different mechanisms. First, inherited piRNAs enhance processing of homologous transcripts into mature piRNAs by initiating the ping-pong cycle in the cytoplasm. Second, inherited piRNAs induce installment of the histone 3 Lys9 trimethylation (H3K9me3) mark on genomic piRNA cluster sequences. The heterochromatin protein 1 (HP1) homolog Rhino binds to the H3K9me3 mark through its chromodomain and is enriched over piRNA clusters. Rhino recruits the piRNA biogenesis factor Cutoff to piRNA clusters and is required for efficient transcription of piRNA precursors. We propose that transgenerationally inherited piRNAs act as an epigenetic memory for identification of substrates for piRNA biogenesis on two levels: by inducing a permissive chromatin environment for piRNA precursor synthesis and by enhancing processing of these precursors. PMID:25085419

  2. Determination of the D{sup 0}{yields}K{sup -}{pi}{sup +}{pi}{sup 0} and D{sup 0}{yields}K{sup -}{pi}{sup +}{pi}{sup +}{pi}{sup -} coherence factors and average strong-phase differences using quantum-correlated measurements

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lowrey, N.; Mehrabyan, S.; Selen, M.

    The first measurements of the coherence factors (R{sub K{pi}}{sub {pi}{sup 0}} and R{sub K3{pi}}) and the average strong-phase differences ({delta}{sub D}{sup K{pi}}{sup {pi}{sup 0}} and {delta}{sub D}{sup K3{pi}}) for D{sup 0}{yields}K{sup -}{pi}{sup +}{pi}{sup 0} and D{sup 0}{yields}K{sup -}{pi}{sup +}{pi}{sup +}{pi}{sup -} are presented. These parameters can be used to improve the determination of the unitarity triangle angle {gamma} in B{sup -}{yields}DK{sup -} decays, where D is a D{sup 0} or D{sup 0} meson decaying to the same final state. The measurements are made using quantum-correlated, fully reconstructed D{sup 0}D{sup 0} pairs produced in e{sup +}e{sup -} collisions at the {psi}(3770)more » resonance. The measured values are: R{sub K{pi}}{sub {pi}{sup 0}}=0.84{+-}0.07, {delta}{sub D}{sup K{pi}}{sup {pi}{sup 0}}=(227{sub -17}{sup +14}) deg., R{sub K3{pi}}=0.33{sub -0.23}{sup +0.20}, and {delta}{sub D}{sup K3{pi}}=(114{sub -23}{sup +26}) deg. These results indicate significant coherence in the decay D{sup 0}{yields}K{sup -}{pi}{sup +}{pi}{sup 0}, whereas lower coherence is observed in the decay D{sup 0}{yields}K{sup -}{pi}{sup +}{pi}{sup +}{pi}{sup -}. The analysis also results in a small improvement in the knowledge of other D-meson parameters, in particular, the strong-phase difference for D{sup 0}{yields}K{sup -}{pi}{sup +}, {delta}{sub D}{sup K{pi}}, and the mixing parameter y.« less

  3. The Search for Exotic Mesons in gamma p -> pi+pi+pi-n with CLAS at Jefferson Lab

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Craig Bookwalter

    2011-12-01

    The {pi}{sub 1}(1600), a J{sup PC} = 1{sup {-+}} exotic meson has been observed by experiments using pion beams. Theorists predict that photon beams could produce gluonic hybrid mesons, of which the {pi}{sub 1}(1600) is a candidate, at enhanced levels relative to pion beams. The g12 rungroup at Jefferson Lab's CEBAF Large Acceptance Spectrometer (CLAS) has recently acquired a large photoproduction dataset, using a liquid hydrogen target and tagged photons from a 5.71 GeV electron beam. A partial-wave analysis of 502K {gamma}p {yields} {pi}{sup +}{pi}{sup +}{pi}{sup -}n events selected from the g12 dataset has been performed, and preliminary fit resultsmore » show strong evidence for well-known states such as the a{sub 1}(1260), a{sub 2}(1320), and {pi}{sub 2}(1670). However, we observe no evidence for the production of the {pi}{sub 1}(1600) in either the partial-wave intensities or the relative complex phase between the 1{sup {-+}} and the 2{sup {-+}} (corresponding to the {pi}{sub 2}) partial waves.« less

  4. 18 CFR 401.33 - Administrative agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... agreements. 401.33 Section 401.33 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION... Administrative agreements. The Executive Director is authorized and directed to enter into cooperative Administrative Agreements with federal and state regulatory agencies concerned with the review of projects under...

  5. 48 CFR 731.109 - Advance agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Advance agreements. 731.109 Section 731.109 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT... agreements. Advance agreements on selected costs may be negotiated with USAID contractors by the Overhead and...

  6. 18 CFR 401.33 - Administrative agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... agreements. 401.33 Section 401.33 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION... Administrative agreements. The Executive Director is authorized and directed to enter into cooperative Administrative Agreements with federal and state regulatory agencies concerned with the review of projects under...

  7. 18 CFR 401.33 - Administrative agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... agreements. 401.33 Section 401.33 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION... Administrative agreements. The Executive Director is authorized and directed to enter into cooperative Administrative Agreements with federal and state regulatory agencies concerned with the review of projects under...

  8. 48 CFR 731.109 - Advance agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Advance agreements. 731.109 Section 731.109 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT... agreements. Advance agreements on selected costs may be negotiated with USAID contractors by the Overhead and...

  9. 48 CFR 731.109 - Advance agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Advance agreements. 731.109 Section 731.109 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT... agreements. Advance agreements on selected costs may be negotiated with USAID contractors by the Overhead and...

  10. 5 CFR 362.106 - Participant Agreement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Participant Agreement. 362.106 Section... PROGRAMS General Provisions § 362.106 Participant Agreement. Agencies must execute a written Participant Agreement with each Pathways Participant that clearly identifies expectations, including but not limited to...

  11. 10 CFR 140.52 - Indemnity agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Indemnity agreements. 140.52 Section 140.52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) FINANCIAL PROTECTION REQUIREMENTS AND INDEMNITY AGREEMENTS Provisions Applicable Only to Federal Agencies § 140.52 Indemnity agreements. (a) The Commission will execute and issue...

  12. 10 CFR 140.52 - Indemnity agreements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Indemnity agreements. 140.52 Section 140.52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) FINANCIAL PROTECTION REQUIREMENTS AND INDEMNITY AGREEMENTS Provisions Applicable Only to Federal Agencies § 140.52 Indemnity agreements. (a) The Commission will execute and issue...

  13. 10 CFR 140.52 - Indemnity agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Indemnity agreements. 140.52 Section 140.52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) FINANCIAL PROTECTION REQUIREMENTS AND INDEMNITY AGREEMENTS Provisions Applicable Only to Federal Agencies § 140.52 Indemnity agreements. (a) The Commission will execute and issue...

  14. 40 CFR 35.1615 - Substate agreements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Substate agreements. 35.1615 Section 35... STATE AND LOCAL ASSISTANCE Cooperative Agreements for Protecting and Restoring Publicly Owned Freshwater Lakes § 35.1615 Substate agreements. States may make financial assistance available to substate agencies...

  15. 40 CFR 35.1615 - Substate agreements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Substate agreements. 35.1615 Section 35... STATE AND LOCAL ASSISTANCE Cooperative Agreements for Protecting and Restoring Publicly Owned Freshwater Lakes § 35.1615 Substate agreements. States may make financial assistance available to substate agencies...

  16. 76 FR 77998 - Market Access Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-15

    ... FARM CREDIT ADMINISTRATION Market Access Agreement AGENCY: Farm Credit Administration. ACTION: Notice of approval of the Draft Second Amended and Restated Market Access Agreement. SUMMARY: The Farm... Access Agreement (Draft Second Restated MAA) proposed to be entered into by all of the banks of the Farm...

  17. 14 CFR 142.33 - Training agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Training agreements. 142.33 Section 142.33... OTHER CERTIFICATED AGENCIES TRAINING CENTERS General § 142.33 Training agreements. A pilot school... certificated under this part if— (a) There is a training, testing, and checking agreement between the...

  18. 5 CFR 370.105 - Written agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Written agreements. 370.105 Section 370... TECHNOLOGY EXCHANGE PROGRAM § 370.105 Written agreements. Before the detail begins, the agency and private sector organization must enter into a written agreement with the individual(s) detailed. The written...

  19. 5 CFR 370.105 - Written agreements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Written agreements. 370.105 Section 370... TECHNOLOGY EXCHANGE PROGRAM § 370.105 Written agreements. Before the detail begins, the agency and private sector organization must enter into a written agreement with the individual(s) detailed. The written...

  20. 14 CFR 141.26 - Training agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Training agreements. 141.26 Section 141.26... OTHER CERTIFICATED AGENCIES PILOT SCHOOLS General § 141.26 Training agreements. (a) A training center... training agreement between the certificated training center and the pilot school; (2) The training, testing...

  1. Measurement of the Branching Ratio Lambda_c+ -> p pi+ pi- (in Spanish)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lopez-Hinojosa, Guillermo; /San Luis Potosi U.

    2008-03-01

    The confirmation of the Cabibbo-suppressed charm baryon decay mode {Lambda}{sub c}{sup +} {yields} p{pi}{sup +}{pi}{sup -} is reported. All data analyzed are from SELEX, a fixed target experiment at Fermilab that took data during 1996 and 1997, mainly with a 600 GeV/c {Sigma}{sup -} beam. The branching ratio of the Cabibbo-suppressed decay mode {Lambda}{sub c}{sup +} {yields} p{pi}{sup +}{pi}{sup -} relative to the Cabibbo-favored mode {Lambda}{sub c}{sup +} {yields} pK{sup -}{pi}{sup +} is measured to be: {Gamma}({Lambda}{sub c}{sup +} {yields} p{pi}{sup +}{pi}{sup -})/{Gamma}({Lambda}{sub c}{sup +} {yields} pK{sup -}{pi}{sup +}) = 0.103 {+-} 0.022.

  2. 30 CFR 735.19 - Grant agreement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Grant agreement. 735.19 Section 735.19 Mineral... AND ENFORCEMENT § 735.19 Grant agreement. (a) If the Director or his authorized designee approves an agency's grant application, the Director or his authorized designee shall prepare a grant agreement which...

  3. 30 CFR 735.19 - Grant agreement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Grant agreement. 735.19 Section 735.19 Mineral... AND ENFORCEMENT § 735.19 Grant agreement. (a) If the Director or his authorized designee approves an agency's grant application, the Director or his authorized designee shall prepare a grant agreement which...

  4. 5 CFR 537.107 - Service agreements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Service agreements. 537.107 Section 537... STUDENT LOANS § 537.107 Service agreements. (a) Before an employing agency makes any loan payments for an employee, the employee (or job candidate) must sign a written service agreement to complete a specified...

  5. 30 CFR 735.19 - Grant agreement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Grant agreement. 735.19 Section 735.19 Mineral... AND ENFORCEMENT § 735.19 Grant agreement. (a) If the Director or his authorized designee approves an agency's grant application, the Director or his authorized designee shall prepare a grant agreement which...

  6. 7 CFR 3560.453 - Workout agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Workout agreements. 3560.453 Section 3560.453... Other Actions § 3560.453 Workout agreements. (a) General. (1) Prevention or resolution of compliance... Agency for approval a workout agreement that proposes actions to be taken over a period of time to...

  7. 5 CFR 537.107 - Service agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Service agreements. 537.107 Section 537... STUDENT LOANS § 537.107 Service agreements. (a) Before an employing agency makes any loan payments for an employee, the employee (or job candidate) must sign a written service agreement to complete a specified...

  8. 7 CFR 3560.453 - Workout agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Workout agreements. 3560.453 Section 3560.453... Other Actions § 3560.453 Workout agreements. (a) General. (1) Prevention or resolution of compliance... Agency for approval a workout agreement that proposes actions to be taken over a period of time to...

  9. Evidence for the decay D0-->K(-)pi(+)pi(-)e(+)nu(e).

    PubMed

    Artuso, M; Blusk, S; Butt, J; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Naik, P; Briere, R A; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Cassel, D G; Duboscq, J E; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Mohapatra, D; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Athar, S B; Patel, R; Potlia, V; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Karliner, I; Kim, D; Lowrey, N; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Smith, A; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Ernst, J; Ecklund, K M; Severini, H; Love, W; Savinov, V; Aquines, O; Lopez, A; Mehrabyan, S; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F

    2007-11-09

    Using a 281 pb{-1} data sample collected at the psi(3770) with the CLEO-c detector, we present the first absolute branching fraction measurement of the decay D0-->K(-)pi(+)pi(-)e(+)nu(e) at a statistical significance of about 4.0 standard deviations. We find 10 candidates consistent with the decay D0-->K(-)pi(+)pi(-)e(+)nu(e). The probability that a background fluctuation accounts for this signal is less than 4.1 x 10{-5}. We find B(D0-->K(-)pi(+)pi(-)e(+)nu(e)) = [2.8{-1.1}{+1.4}(stat)+/-0.3(syst)]x10{-4}. By restricting the invariant mass of the hadronic system to be consistent with K1(1270), we obtain the product of branching fractions B(D{0}-->K{1}{-}(1270)e{+}nu{e})xB(K1-(1270)-->K{-}pi{+}pi{-})=[2.5{-1.0}{+1.3}(stat)+/-0.2(syst)]x10{-4}. Using B(K1-(1270)-->K{-}pi{+}pi{-})=(33+/-3)%, we obtain B(D{0}-->K{1}{-}(1270)e{+}nu{e})=[7.6{-3.0}{+4.1}(stat)+/-0.6(syst)+/-0.7]x10{-4}. The last error accounts for the uncertainties in the measured K1-(1270)-->K{-}pi{+}pi{-} branching fractions.

  10. 77 FR 20353 - United States Warehouse Act; Export Food Aid Commodities Licensing Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-04

    ... States Warehouse Act; Export Food Aid Commodities Licensing Agreement AGENCY: Farm Service Agency, USDA... the new Export Food Aid Commodities (EFAC) licensing agreement offered by the Farm Service Agency (FSA.... This licensing agreement was developed in response to concerns of export food aid providers...

  11. Impact of Clinical History on Maximum PI-RADS Version 2 Score: A Six-Reader 120-Case Sham History Retrospective Evaluation.

    PubMed

    Shankar, Prasad R; Kaza, Ravi K; Al-Hawary, Mahmoud M; Masch, William R; Curci, Nicole E; Mendiratta-Lala, Mishal; Sakala, Michelle D; Johnson, Timothy D; Davenport, Matthew S

    2018-04-17

    Purpose To assess the impact of clinical history on the maximum Prostate Imaging Recording and Data System (PI-RADS) version 2 (v2) score assigned to multiparametric magnetic resonance (MR) imaging of the prostate. Materials and Methods This retrospective cohort study included 120 consecutively selected multiparametric prostate MR imaging studies performed between November 1, 2016, and December 31, 2016. Sham clinical data in four domains (digital rectal examination, prostate-specific antigen level, plan for biopsy, prior prostate cancer history) were randomly assigned to each case by using a balanced orthogonal design. Six fellowship-trained abdominal radiologists independently reviewed the sham data, actual patient age, and each examination while they were blinded to interreader scoring, true clinical data, and histologic findings. Readers were told the constant sham histories were true, believed the study to be primarily investigating interrater agreement, and were asked to assign a maximum PI-RADS v2 score to each case. Linear regression was performed to assess the association between clinical variables and maximum PI-RADS v2 score designation. Intraclass correlation coefficients (ICCs) were obtained to compare interreader scoring. Results Clinical information had no significant effect on maximum PI-RADS v2 scoring for any of the six readers (P = .09-.99, 42 reader-variable pairs). Distributions of maximum PI-RADS v2 scores in the research context were similar to the distribution of the scores assigned clinically and had fair-to-excellent pairwise interrater agreement (ICC range: 0.53-0.76). Overall interrater agreement was good (ICC: 0.64; 95% confidence interval: 0.57, 0.71). Conclusion Clinical history does not appear to be a substantial bias in maximum PI-RADS v2 score assignment. This is potentially important for clinical nomograms that plan to incorporate PI-RADS v2 score and clinical data into their algorithms (ie, PI-RADS v2 scoring is not confounded by

  12. Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

    PubMed

    Vernon, Robert McCoy; Chong, Paul Andrew; Tsang, Brian; Kim, Tae Hun; Bah, Alaji; Farber, Patrick; Lin, Hong; Forman-Kay, Julie Deborah

    2018-02-09

    Protein phase separation is implicated in formation of membraneless organelles, signaling puncta and the nuclear pore. Multivalent interactions of modular binding domains and their target motifs can drive phase separation. However, forces promoting the more common phase separation of intrinsically disordered regions are less understood, with suggested roles for multivalent cation-pi, pi-pi, and charge interactions and the hydrophobic effect. Known phase-separating proteins are enriched in pi-orbital containing residues and thus we analyzed pi-interactions in folded proteins. We found that pi-pi interactions involving non-aromatic groups are widespread, underestimated by force-fields used in structure calculations and correlated with solvation and lack of regular secondary structure, properties associated with disordered regions. We present a phase separation predictive algorithm based on pi interaction frequency, highlighting proteins involved in biomaterials and RNA processing. © 2018, Vernon et al.

  13. Pi-Pi contacts are an overlooked protein feature relevant to phase separation

    PubMed Central

    Vernon, Robert McCoy; Chong, Paul Andrew; Tsang, Brian; Kim, Tae Hun; Bah, Alaji; Farber, Patrick; Lin, Hong

    2018-01-01

    Protein phase separation is implicated in formation of membraneless organelles, signaling puncta and the nuclear pore. Multivalent interactions of modular binding domains and their target motifs can drive phase separation. However, forces promoting the more common phase separation of intrinsically disordered regions are less understood, with suggested roles for multivalent cation-pi, pi-pi, and charge interactions and the hydrophobic effect. Known phase-separating proteins are enriched in pi-orbital containing residues and thus we analyzed pi-interactions in folded proteins. We found that pi-pi interactions involving non-aromatic groups are widespread, underestimated by force-fields used in structure calculations and correlated with solvation and lack of regular secondary structure, properties associated with disordered regions. We present a phase separation predictive algorithm based on pi interaction frequency, highlighting proteins involved in biomaterials and RNA processing. PMID:29424691

  14. Dispersion relations with crossing symmetry for {pi}{pi} D- and F-wave amplitudes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kaminski, R.

    A set of once subtracted dispersion relations with imposed crossing symmetry condition for the {pi}{pi} D- and F-wave amplitudes is derived and analyzed. An example of numerical calculations in the effective two-pion mass range from the threshold to 1.1 GeV is presented. It is shown that these new dispersion relations impose quite strong constraints on the analyzed {pi}{pi} interactions and are very useful tools to test the {pi}{pi} amplitudes. One of the goals of this work is to provide a complete set of equations required for easy use. Full analytical expressions are presented. Along with the well-known dispersion relations successfulmore » in testing the {pi}{pi} S- and P-wave amplitudes, those presented here for the D and F waves give a complete set of tools for analyses of the {pi}{pi} interactions.« less

  15. Diagnostic performance and reproducibility of T2w based and diffusion weighted imaging (DWI) based PI-RADSv2 lexicon descriptors for prostate MRI.

    PubMed

    Benndorf, Matthias; Hahn, Felix; Krönig, Malte; Jilg, Cordula Annette; Krauss, Tobias; Langer, Mathias; Dovi-Akué, Philippe

    2017-08-01

    To examine the diagnostic performance of PI-RADSv2 T2w and diffusion weighted imaging (DWI) based lexicon descriptors, inter-observer agreement for descriptor assignment and diagnostic accuracy of the PI-RADSv2 assessment categories for multiparametric prostate MRI. 176 lesions in 79 consecutive patients are analyzed, lesions are histopathologically verified by MRI-ultrasound fusion biopsy. All lesions are rated according to the PI-RADSv2 lexicon, descriptors for T2w and DWI sequences and resulting assessment categories are assigned by two independent blinded radiologists. We perform receiver-operating-characteristic analysis using the assessment categories. To analyze inter-observer agreement, we calculate weighted kappa values for assessment category assignment and unweighted kappa values for descriptor assignment. PI-RADSv2 assessment categories yield an area under the curve of 0.76/0.74 (radiologist 1/radiologist 2), P >0.05. Weighted kappa for agreement is 0.601 in the peripheral zone and 0.580 in the transition zone. We detect a difference in the cancer rate for PI-RADSv2 category 3 between peripheral zone (32%) and transition zone (12%), P <0.05. We obtain moderate agreement at most for descriptor assignment with kappa values ranging from 0.082 (T2w shape in the transition zone) to 0.407 (T2w signal intensity in the peripheral zone) and 0.493 (ADC pattern in the peripheral zone). Our analysis corroborates typical descriptors for benign/malignant lesions, but also reveals insights into potential pitfalls - T2w wedge shaped lesions in the peripheral zone have a considerable cancer rate, despite being labelled category 2 in the lexicon. Agreement for descriptor assignment in the PI-RADSv2 lexicon is at most moderate in our study. Typical descriptors for benign and malignant lesions are validated, whereas the discriminatory power of some descriptors is challenged. The difference in the cancer rate for PI-RADSv2 category 3 between peripheral zone and transition

  16. Observation of an enhancement in e{sup +}e{sup -}{yields}{Upsilon}(1S){pi}{sup +}{pi}{sup -}, {Upsilon}(2S){pi}{sup +}{pi}{sup -}, and {Upsilon}(3S){pi}{sup +}{pi}{sup -} production near {radical}(s)=10.89 GeV

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chen, K.-F.; Hou, W.-S.; Chang, P.

    2010-11-01

    We measure the production cross sections for e{sup +}e{sup -}{yields}{Upsilon}(1S){pi}{sup +}{pi}{sup -}, {Upsilon}(2S){pi}{sup +}{pi}{sup -}, and {Upsilon}(3S){pi}{sup +}{pi}{sup -} as a function of {radical}(s) between 10.83 GeV and 11.02 GeV. The data consist of 8.1 fb{sup -1} collected with the Belle detector at the KEKB e{sup +}e{sup -} collider. We observe enhanced production in all three final states that does not agree well with the conventional {Upsilon}(10860) line shape. A fit using a Breit-Wigner resonance shape yields a peak mass of [10 888.4{sub -2.6}{sup +2.7}(stat){+-}1.2(syst)] MeV/c{sup 2} and a width of [30.7{sub -7.0}{sup +8.3}(stat){+-}3.1(syst)] MeV/c{sup 2}.

  17. Cross Sections for the Reactions e+e to K+ K- pi+pi-, K+ K- pi0pi0, and K+ K- K+ K- Measured Using Initial-State Radiation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lees, J.P.; Poireau, V.; Prencipe, E.

    2011-08-19

    We study the processes e{sup +}e{sup -} {yields} K{sup +}K{sup -}{pi}{sup +}{pi}-{gamma}, K{sup +}K{sup -}{pi}{sup 0}{pi}{sup 0}{gamma}, and K{sup +}K{sup -}K{sup +}K{sup -}{gamma}, where the photon is radiated from the initial state. About 84000, 8000, and 4200 fully reconstructed events, respectively, are selected from 454 fb{sup -1} of BABAR data. The invariant mass of the hadronic final state defines the e{sup +}e{sup -} center-of-mass energy, so that the K{sup +}K{sup -}{pi}{sup +}{pi}{sup -}{gamma} data can be compared with direct measurements of the e{sup +}e{sup -} {yields} K{sup +}K{sup -}{pi}{sup +}{pi}{sup -} reaction. No direct measurements exist for the e{sup +}e{supmore » -} {yields} K{sup +}K{sup -}{pi}{sup 0}{pi}{sup 0} or e{sup +}e{sup -} {yields} K{sup +}K{sup -}K{sup +}K{sup -} reactions, and we present an update of our previous result with doubled statistics. Studying the structure of these events, we find contributions from a number of intermediate states, and extract their cross sections. In particular, we perform a more detailed study of the e{sup +}e{sup -} {yields} {phi}(1020){pi}{pi}{gamma} reaction, and confirm the presence of the Y (2175) resonance in the {phi}(1020)f{sub 0}(980) and K{sup +}K{sup -} f{sub 0}(980) modes. In the charmonium region, we observe the J/{psi} in all three final states and in several intermediate states, as well as the {phi}(2S) in some modes, and measure the corresponding branching fractions.« less

  18. Noncoding RNA. piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production.

    PubMed

    Han, Bo W; Wang, Wei; Li, Chengjian; Weng, Zhiping; Zamore, Phillip D

    2015-05-15

    PIWI-interacting RNAs (piRNAs) protect the animal germ line by silencing transposons. Primary piRNAs, generated from transcripts of genomic transposon "junkyards" (piRNA clusters), are amplified by the "ping-pong" pathway, yielding secondary piRNAs. We report that secondary piRNAs, bound to the PIWI protein Ago3, can initiate primary piRNA production from cleaved transposon RNAs. The first ~26 nucleotides (nt) of each cleaved RNA becomes a secondary piRNA, but the subsequent ~26 nt become the first in a series of phased primary piRNAs that bind Piwi, allowing piRNAs to spread beyond the site of RNA cleavage. The ping-pong pathway increases only the abundance of piRNAs, whereas production of phased primary piRNAs from cleaved transposon RNAs adds sequence diversity to the piRNA pool, allowing adaptation to changes in transposon sequence. Copyright © 2015, American Association for the Advancement of Science.

  19. Determination of {pi}{sup {+-}} meson polarizabilities from the {gamma}{gamma}{yields}{pi}{sup +}{pi}{sup -} process

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fil'kov, L.V.; Kashevarov, V.L.

    2006-03-15

    A fit of the experimental data to the total cross section of the process {gamma}{gamma}{yields}{pi}{sup +}{pi}{sup -} in the energy region from threshold to 2500 MeV has been carried out using dispersion relations with subtractions for the invariant amplitudes, where the dipole and the quadrupole polarizabilities of the charged pion are free parameters. As a result, the sum and the difference of the electric and magnetic dipole and quadrupole polarizabilities of the charged pion have been found: ({alpha}{sub 1}+{beta}{sub 1}){sub {pi}{sup {+-}}}=(0.18{sub -0.02}{sup +0.11})x10{sup -4} fm{sup 3},({alpha}{sub 1}-{beta}{sub 1}){sub {pi}{sup {+-}}}=(13.0{sub -1.9}{sup +2.6})x10{sup -4} fm{sup 3},({alpha}{sub 2}+{beta}{sub 2}){sub {pi}{sup {+-}}}=(0.133{+-}0.015)x10{supmore » -4} fm{sup 5},({alpha}{sub 2}-{beta}{sub 2}){sub {pi}{sup {+-}}}=(25.0{sub -0.3}{sup +0.8})x10{sup -4} fm{sup 5}. These values agree with the dispersion sum rule predictions. The value found for the difference of the dipole polarizabilities is consistent with the results obtained from scattering of high energy {pi}{sup -} mesons off the Coulomb field of heavy nuclei [Yu. M. Antipov et al., Phys. Lett. B121, 445 (1983)] and from radiative {pi}{sup +} photoproduction from the proton at MAMI [J. Ahrens et al., Eur. Phys. J. A 23, 113 (2005)], whereas it is at variance with the recent calculations in the framework of chiral perturbation theory.« less

  20. 75 FR 54352 - Agency Information Collection Activities: Free Trade Agreements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-07

    ... collection: Chile, Singapore, Australia, Morocco, Bahrain, Jordan, Oman, and Peru. These agreements involve... addition of free trade agreements with Oman and Peru. Type of Review: Extension (with change). Affected...

  1. 41 CFR 302-15.12 - If my agency is paying for property management services under this part and my service agreement...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false If my agency is paying for property management services under this part and my service agreement expires, what must I do to ensure that payment for property management services continues? 302-15.12 Section 302-15.12 Public Contracts and Property Management Federal Travel...

  2. 2 CFR 176.20 - Agency responsibilities (general).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Agency responsibilities (general). 176.20 Section 176.20 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements... enforcement or termination action in accordance with 2 CFR 215.62 or the agency's implementation of the OMB...

  3. 2 CFR 176.20 - Agency responsibilities (general).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Agency responsibilities (general). 176.20 Section 176.20 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements... enforcement or termination action in accordance with 2 CFR 215.62 or the agency's implementation of the OMB...

  4. 2 CFR 176.20 - Agency responsibilities (general).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Agency responsibilities (general). 176.20 Section 176.20 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements... enforcement or termination action in accordance with 2 CFR 215.62 or the agency's implementation of the OMB...

  5. 2 CFR 176.20 - Agency responsibilities (general).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Agency responsibilities (general). 176.20 Section 176.20 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements... enforcement or termination action in accordance with 2 CFR 215.62 or the agency's implementation of the OMB...

  6. 24 CFR 266.15 - Risk-Sharing Agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Risk-Sharing Agreement. 266.15... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS General Provisions § 266.15 Risk-Sharing Agreement. Execution of a Risk-Sharing Agreement is a prerequisite to...

  7. 23 CFR 450.314 - Metropolitan planning agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... among the State department of transportation, State air quality agency, affected local agencies, and the... within the nonattainment or maintenance area. The agreement must also indicate how the total... the designated agency for air quality planning under section 174 of the Clean Air Act (42 U.S.C. 7504...

  8. 34 CFR 303.523 - Interagency agreements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... agency for paying for early intervention services (consistent with State law and the requirements of this... AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EARLY INTERVENTION PROGRAM FOR INFANTS AND... interagency agreements with other State-level agencies involved in the State's early intervention program...

  9. 34 CFR 303.523 - Interagency agreements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... agency for paying for early intervention services (consistent with State law and the requirements of this... AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EARLY INTERVENTION PROGRAM FOR INFANTS AND... interagency agreements with other State-level agencies involved in the State's early intervention program...

  10. 2 CFR 1.305 - Federal agency responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Federal agency responsibilities. 1.305 Section 1.305 Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Responsibilities of OMB and Federal Agencies § 1.305 Federal agency responsibilities. The head of each Federal...

  11. Comparison of D--> KS0 pi and D--> KL0 pi decay rates.

    PubMed

    He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Coan, T E; Gao, Y S; Artuso, M; Blusk, S; Butt, J; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Briere, R A; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Cassel, D G; Duboscq, J E; Ehrlich, R; Fields, L; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Weinberger, M; Athar, S B; Patel, R; Potlia, V; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Karliner, I; Kim, D; Lowrey, N; Naik, P; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Smith, A; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Ernst, J; Ecklund, K M; Severini, H; Love, W; Savinov, V; Aquines, O; Li, Z; Lopez, A; Mehrabyan, S; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J

    2008-03-07

    We present measurements of D--> KS0 pi and D--> KL0 pi branching fractions using 281 pb(-1) of psi(3770) data at the CLEO-c experiment. We find that B(D0--> KS0 pi 0) is larger than B(D0--> KL0 pi 0), with an asymmetry of R(D0)=0.108+/-0.025+/-0.024. For B(D+--> KS0 pi+) and B(D+--> KL0 pi+), we observe no measurable difference; the asymmetry is R(D+)=0.022+/-0.016+/-0.018. The D0 asymmetry is consistent with the value based on the U-spin prediction A(D0--> K0 pi 0)/A(D0--> K0 pi 0)=-tan2 theta C, where theta C is the Cabibbo angle.

  12. 5 CFR 370.105 - Written agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Written agreements. 370.105 Section 370.105 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS INFORMATION TECHNOLOGY EXCHANGE PROGRAM § 370.105 Written agreements. Before the detail begins, the agency and private...

  13. 40 CFR 262.58 - International agreements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false International agreements. 262.58 Section 262.58 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... International agreements. (a) Any person who exports or imports wastes that are considered hazardous under U.S...

  14. 40 CFR 262.58 - International agreements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false International agreements. 262.58 Section 262.58 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... International agreements. (a) Any person who exports or imports wastes that are considered hazardous under U.S...

  15. 22 CFR 312.620 - Cooperative agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Foreign Relations PEACE CORPS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 312.620 Cooperative agreement. Cooperative agreement means an award of financial assistance that... definition of grant in § 312.650), except that substantial involvement is expected between the Federal agency...

  16. Conversion of phosphatidylinositol (PI) to PI4-phosphate (PI4P) and then to PI(4,5)P2 is essential for the cytosolic Ca2+ concentration under heat stress in Ganoderma lucidum.

    PubMed

    Liu, Yong-Nan; Lu, Xiao-Xiao; Ren, Ang; Shi, Liang; Zhu, Jing; Jiang, Ai-Liang; Yu, Han-Shou; Zhao, Ming-Wen

    2018-04-26

    How cells drive the phospholipid signal response to heat stress (HS) to maintain cellular homeostasis is a fundamental issue in biology, but the regulatory mechanism of this fundamental process is unclear. Previous quantitative analyses of lipids showed that phosphatidylinositol (PI) accumulates after HS in Ganoderma lucidum, implying the inositol phospholipid signal may be associated with HS signal transduction. Here, we found that the PI-4-kinase and PI-4-phosphate-5-kinase activities are activated and that their lipid products PI-4-phosphate and PI-4,5-bisphosphate are increased under HS. Further experimental results showed that the cytosolic Ca 2+ ([Ca 2+ ] c ) and ganoderic acid (GA) contents induced by HS were decreased when cells were pretreated with Li + , an inhibitor of inositol monophosphatase, and this decrease could be rescued by PI and PI-4-phosphate. Furthermore, inhibition of PI-4-kinases resulted in a decrease in the Ca 2+ and GA contents under HS that could be rescued by PI-4-phosphate but not PI. However, the decrease in the Ca 2+ and GA contents by silencing of PI-4-phosphate-5-kinase could not be rescued by PI-4-phosphate. Taken together, our study reveals the essential role of the step converting PI to PI-4-phosphate and then to PI-4,5-bisphosphate in [Ca 2+ ] c signalling and GA biosynthesis under HS. © 2018 Society for Applied Microbiology and John Wiley & Sons Ltd.

  17. Spermatozoa Expression of piR-31704, piR-39888, and piR-40349 and Their Correlation to Sperm Concentration and Fertilization Rate After ICSI.

    PubMed

    Cui, Long; Fang, Li; Shi, Biwei; Qiu, Sunquan; Ye, Yinghui

    2018-05-01

    To investigate the relationship between spermatozoa PIWI-interacting RNAs (piRNAs) levels and semen parameters and to evaluate the role of expression of piRNAs on fertilization and embryo development after intracytoplasmic sperm injection (ICSI) treatment. One hundred and eighty-six patients with idiopathic male infertility who had undergone first ICSI cycles were enrolled in our study. The levels of piRNAs in spermatozoa were measured by real-time polymerase chain reaction. Semen parameters, including sperm concentration, motility, and morphology, were evaluated. The rates of fertilization, early cleavage, and day 3 good-quality embryo were calculated to assess embryo development potential. Spermatozoa levels of piR-31704 and piR-39888 were decreased in male factor infertility group as compared with control group (for piR-31704, P = .027 and for piR-39888, P = .041, respectively). And these 2 piRNAs were expressed at higher levels in patients with normal sperm concentration compared with subnormal sperm concentration group (for piR-31704, P = .042; for piR-39888, P = .047, respectively), while there were no correlation between the 3 piRNAs expression levels in spermatozoa and the rates of sperm progressive motility and normal sperm morphology. There were significant increases in the levels of all 3 piRNAs in spermatozoa from the group with higher 2PN rates (for piR-31704, P = .002; for piR-39888, P < .001; for piR-40349, P < .001; respectively), but there was no correlation between spermatozoa levels of these 3 piRNAs and the rates of embryo early cleavage, day 3 good-quality embryos and pregnancy. Spermatozoa piRNA levels correlate with sperm concentration and fertilization rate after ICSI. Paternal piRNAs may play a role in fertilization process.

  18. Amplitude Analysis of B0 to K^ pi^-pi^0 and Evidence of Direct CP Violation in B to K^* pi decays

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lees, J.P.

    We analyze the decay B{sup 0} {yields} K{sup +} {pi}{sup -} {pi}{sup 0} with a sample of 454 million B{bar B} events collected by the BABAR detector at the PEP-II asymmetric-energy B factory at SLAC, and extract the complex amplitudes of seven interfering resonances over the Dalitz plot. These results are combined with amplitudes measured in B{sup 0} {yields} K{sup 0}{sub s}{pi}{sup +}{pi}{sup -} decays to construct isospin amplitudes from B{sup 0} {yields} K{sup *}{pi} and B{sup 0} {yields} {rho}K decays. We measure the phase of the isospin amplitude {Phi}{sub 3/2}, useful in constraining the CKM unitarity triangle angle {gamma}more » and evaluate a CP rate asymmetry sum rule sensitive to the presence of new physics operators. We measure direct CP violation in B{sup 0} {yields} K{sup *+}{pi}{sup -} decays at the level of 3 {sigma} when measurements from both B{sup 0} {yields} K{sup +}{pi}{sup -}{pi}{sup 0} and B{sup 0} {yields} K{sup 0}{sub s}{pi}{sup +}{pi}{sup -} decays are combined.« less

  19. 4th Annual DOE-ERSP PI Meeting: Abstracts

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hazen, Terry C.

    2009-03-01

    This contains abstracts from the 2009 Annual Environmental Remediation Sciences Program (ERSP) Principal Investigators (PI) Meeting. The ERSP seeks to advance fundamental science to understand, predict, and mitigate the impacts of environmental contamination from past nuclear weapons production and provide a scientific basis for the long-term stewardship of nuclear waste disposal. These ambitious goals cannot be achieved by any one project alone. Therefore, ERSP funds a combination of research programs at the DOE national laboratories, individual projects at universities and federal agencies, and large long(er)-term field site research. Integration of these activities to advance the ERSP goals is a constantmore » challenge, but made significantly simpler by bringing together all funded ERSP researchers once a year to discuss the very latest research results. It is at these meetings where new ideas and/or scientific advancements in support of ERSP goals can be discussed and openly debated among all PIs in the program. The ERSP thrives, in part, on the new ideas, concepts, scientific connections, and collaborations generated as a result of these meetings. The annual PI Meeting is very much a working meeting with three major goals: (1) to provide opportunities for scientific interaction among the ERSP scientists, a critical element for the program; (2) to provide the ERSP program staff with an opportunity to evaluate the progress of each program and project; and (3) to showcase the ERSP to interested parties within DOE and within other federal agencies In addition to program managers from within OBER, there will be representatives from other offices within DOE and other federal agencies in attandance at the meeting.« less

  20. Pickup Protons: Comparisons using the Three-Dimensional MHD HHMS-PI model and Ulysses SWICS Measurements

    NASA Technical Reports Server (NTRS)

    Intriligator, Devrie S.; Detman, Thomas; Gloecker, George; Gloeckler, Christine; Dryer, Murray; Sun, Wei; Intriligator, James; Deehr, Charles

    2012-01-01

    We report the first comparisons of pickup proton simulation results with in situ measurements of pickup protons obtained by the SWICS instrument on Ulysses. Simulations were run using the three dimensional (3D) time-dependent Hybrid Heliospheric Modeling System with Pickup Protons (HHMS-PI). HHMS-PI is an MHD solar wind model, expanded to include the basic physics of pickup protons from neutral hydrogen that drifts into the heliosphere from the local interstellar medium. We use the same model and input data developed by Detman et al. (2011) to now investigate the pickup protons. The simulated interval of 82 days in 2003 2004, includes both quiet solar wind (SW) and also the October November 2003 solar events (the Halloween 2003 solar storms). The HHMS-PI pickup proton simulations generally agree with the SWICS measurements and the HHMS-PI simulated solar wind generally agrees with SWOOPS (also on Ulysses) measurements. Many specific features in the observations are well represented by the model. We simulated twenty specific solar events associated with the Halloween 2003 storm. We give the specific values of the solar input parameters for the HHMS-PI simulations that provide the best combined agreement in the times of arrival of the solar-generated shocks at both ACE and Ulysses. We show graphical comparisons of simulated and observed parameters, and we give quantitative measures of the agreement of simulated with observed parameters. We suggest that some of the variations in the pickup proton density during the Halloween 2003 solar events may be attributed to depletion of the inflowing local interstellar medium (LISM) neutral hydrogen (H) caused by its increased conversion to pickup protons in the immediately preceding shock.

  1. 78 FR 53702 - User Fees for Processing Installment Agreements and Offers in Compromise

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ... User Fees for Processing Installment Agreements and Offers in Compromise AGENCY: Internal Revenue... document contains proposed amendments to the regulations that provide user fees for installment agreements... agencies to prescribe regulations that establish charges for services provided by the agencies (user fees...

  2. Watershed Management Partnership Agreement

    EPA Pesticide Factsheets

    On November 19, 2004, the U.S. Environmental Protection Agency and the U.S. Army Corps of Engineers signed the Watershed Management Partnership Agreement to promote watershed health, economic sustainability and community vitality through effective manageme

  3. 2 CFR 25.300 - Agency.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Agency. 25.300 Section 25.300 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS PRE-AWARD RESPONSIBILITIES UNIVERSAL IDENTIFIER AND CENTRAL...

  4. 2 CFR 25.300 - Agency.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Agency. 25.300 Section 25.300 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS PRE-AWARD RESPONSIBILITIES UNIVERSAL IDENTIFIER AND CENTRAL...

  5. 2 CFR 170.300 - Agency.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Agency. 170.300 Section 170.300 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved REPORTING SUBAWARD AND EXECUTIVE COMPENSATION...

  6. 2 CFR 170.300 - Agency.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Agency. 170.300 Section 170.300 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS NATIONAL POLICY REQUIREMENTS REPORTING SUBAWARD AND EXECUTIVE...

  7. 2 CFR 170.300 - Agency.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Agency. 170.300 Section 170.300 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS NATIONAL POLICY REQUIREMENTS REPORTING SUBAWARD AND EXECUTIVE...

  8. 2 CFR 25.300 - Agency.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Agency. 25.300 Section 25.300 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved UNIVERSAL IDENTIFIER AND CENTRAL CONTRACTOR...

  9. 2 CFR 170.300 - Agency.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Agency. 170.300 Section 170.300 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS [Reserved] REPORTING SUBAWARD AND EXECUTIVE COMPENSATION...

  10. 2 CFR 25.300 - Agency.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Agency. 25.300 Section 25.300 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Pre-award responsibilities UNIVERSAL IDENTIFIER AND CENTRAL...

  11. The Story of PI

    NASA Technical Reports Server (NTRS)

    Apostol, Tom M. (Editor)

    1989-01-01

    The early history and the uses of the mathematical notation - pi - are presented through both film footage and computer animation in this 'Project Mathematics' series video. Pi comes from the first letter in the Greek word for perimeter. Archimedes, and early Greek mathematician, formulated the equations for the computation of a circle's area using pi and was the first person to seriously approximate pi numerically, although only to a few decimal places. By 1985, pi had been approximated to over one billion decimal places and was found to have no repeating pattern. One use of pi is the application of its approximation calculation as an analytical tool for determining the accuracy of supercomputers and software designs.

  12. Search for resonances decaying to etac pi pi- in two-photon interactions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lees, J.P.; Poireau, V.; Tisserand, V.

    2012-06-18

    We report a study of the process {gamma}{gamma} {yields} X {yields} {eta}{sub c}{pi}{sup +}{pi}{sup -}, where X stands for one of the resonances {chi}{sub c2}(1P), {eta}{sub c}(2S), X(3872), X(3915), or {chi}{sub c2}(2P). The analysis is performed with a data sample of 473.9 fb{sup -1} collected with the BABAR detector at the PEP-II asymmetric-energy electron-positron collider. We do not observe a significant signal for any channel, and calculate 90% confidence-level upper limits on the products of branching fractions and two-photon widths {Lambda}{sub X{yields}{gamma}{gamma}} {Beta}(X {yields} {eta}{sub c}{pi}{sup +}{pi}{sup -}): 15.7 eV for {chi}{sub c2}(1P), 133 eV for {eta}{sub c}(2S), 11.1 eVmore » for X(3872) (assuming it to be a spin-2 state), 16 eV for X(3915) (assuming it to be a spin-2 state), and 19 eV for {chi}{sub c2}(2P). We also report upper limits on the ratios of branching fractions {Beta}({eta}{sub c}(2S) {yields} {eta}{sub c}{pi}{sup +}{pi}{sup -})/{Beta}({eta}{sub c}(2S) {yields} K{sub S}{sup 0}K{sup +}{pi}{sup -}) < 10.0 and {Beta}({chi}{sub c2}(1P) {yields} {eta}{sub c}{pi}{sup +}{pi}{sup -})/{Beta}({chi}{sub c2}(1P) {yields} K{sub S}{sup 0}K{sup +}{pi}{sup -}) < 32.9 at the 90% confidence level.« less

  13. PI-RADS version 2: evaluation of diffusion-weighted imaging interpretation between b = 1000 and b = 1500 s mm-2.

    PubMed

    Kwon, Mi-Ri; Kim, Chan Kyo; Kim, Jae-Hun

    2017-11-01

    To investigate the variability of diffusion-weighted imaging (DWI) interpretation of Prostate Imaging Reporting and Data System (PI-RADS) version 2 (v2) in evaluating prostate cancer (PCa). 154 patients with PCa underwent multiparametric 3T MRI, followed by radical prostatectomy. DWI with different b values (b = 0, 100, 1000 and 1500 s mm - 2 ) was obtained. Using the PI-RADS v2, two radiologists independently scored suspicious lesions in each patient and compared DWI of b = 1000 (DWI 1000 ) with 1500 (DWI 1500 ) s mm - 2 . On DWI 1000 and DWI 1500 , the intermethod and interobserver agreements of DWI scores were excellent in all patients (κ ≥ 0.873). In each peripheral zone and transition zone DWI scores, both observers showed excellent intermethod agreement between DWI 1000 and DWI 1500 (κ ≥ 0.897), and interobserver agreement for DWI 1000 and DWI 1500 was good to excellent (κ ≥ 0.796). For estimating clinically significant cancer, the area under receiver operating characteristics curves of DWI 1000 and DWI 1500 were 0.710 and 0.724 for observer 1 (p = 0.11), and 0.649 and 0.656 for observer 2 (p = 0.12), respectively. The PI-RADS v2 scoring at 3T shows excellent agreement between DWI 1000 and DWI 1500 in evaluating PCa, with excellent inter-observer agreement. Advance in knowledge: DWI using b = 1000 s mm -2 instead of b = 1500 s mm -2 reduces examination time or image distortion, with improved the signal-to-noise ratio.

  14. Measurement of the K- pi+ S-wave system in D+ ---> K- pi+ pi+ decays from Fermilab E791

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Meadows, B.; /Cincinnati U.

    A new approach to the analysis of three body decays is presented. Measurements of the S-wave K{pi} amplitude are made in independent ranges of invariant mass from threshold up to the upper kinematic limit in D{sup +} {yields} K{sup -}{pi}{sup +}{pi}{sup +} decays. These are compared with results obtained from a fit where the S-wave is assumed to have {kappa} and K{sub 0}{sup +}(1430) resonances. Results are also compared with measurements of K{sup -} {pi}{sup +} elastic scattering. Contributions from I = 1/2 and I = 3/2 are not resolved in this study. If I = 1/2 dominates, however, themore » Watson theorem prediction, that the phase behavior below K{eta}' threshold should match that in elastic scattering, is not well supported by these data. Production of K{sup -} {pi}{sup +} from these D decays is also studied.« less

  15. Study of the Rare Hyperon Decay $${\\boldmath \\Omega^\\mp \\to \\Xi^\\mp \\: \\pi^+\\pi^-}$$

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kamaev, O.; Solomey, N.; Burnstein, R.A.

    The authors report a new measurement of the decay {Omega}{sup -} {yields} {Xi}{sup -} {pi}{sup +}{pi}{sup -} with 76 events and a first observation of the decay {bar {Omega}}{sup +} {yields} {bar {Xi}}{sup +} {pi}{sup +}{pi}{sup -} with 24 events, yielding a combined branching ratio (3.74{sub -0.56}{sup +0.67}) x 10{sup -4}. This represents a factor 25 increase in statistics over the best previous measurement. No evidence is seen for CP violation, with {Beta}({Omega}{sup -} {yields} {Xi}{sup -} {pi}{sup +}{pi}{sup -}) = 4.04{sub -0.71}{sup +0.83} x 10{sup -4} and {Beta}({bar {Omega}}{sup +} {yields} {bar {Xi}}{sup +} {pi}{sup +}{pi}{sup -}) = 3.15{submore » -0.89}{sup +1.12} x 10{sup -4}. Contrary to theoretical expectation, they see little evidence for the decays {Omega}{sup -} {yields} {Xi}*{sub 1530}{sup 0} {pi}{sup -} and {bar {Omega}}{sup +} {yields} {bar {Xi}}*{sub 1530}{sup 0} {pi}{sup +} and place a 90% C.L. upper limit on the combined branching ratio {Beta}({Omega}{sup -}({bar {Omega}}{sup +}) {yields} {Xi}*{sub 1530}{sup 0} ({bar {Xi}}*{sub 1530}{sup 0}){pi}{sup {-+}}) < 7.0 x 10{sup -5}.« less

  16. 14 CFR 142.33 - Training agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Training agreements. 142.33 Section 142.33... OTHER CERTIFICATED AGENCIES TRAINING CENTERS General § 142.33 Training agreements. A pilot school certificated under part 141 of this chapter may provide training, testing, and checking for a training center...

  17. 14 CFR 141.26 - Training agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Training agreements. 141.26 Section 141.26... OTHER CERTIFICATED AGENCIES PILOT SCHOOLS General § 141.26 Training agreements. A training center certificated under part 142 of this chapter may provide the training, testing, and checking for pilot schools...

  18. 30 CFR 936.30 - State-Federal Cooperative Agreement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...: Article I: Introduction, Purpose, and Responsible Agencies A. This Agreement is authorized by section 523... this Agreement on behalf of the Secretary. Article II: Effective Date After being signed by the... Register as a final rule. This Agreement shall remain in effect until terminated as provided in Article XI...

  19. The p({gamma}, {pi}{sup 0}) reaction in the {Delta}(1232) region

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Davidson, R.M.; Gutenberg, J.; Mukhopadhyay, N.C.

    Linearly polarized photons from the Laser Electron Gamma Source (LEGS) have been used by Blanpied et al. to study the p({gamma}, {pi}{sup 0}) reaction, looking for the E2 transition amplitude in the nucleon to Delta(1232) excitation. These authors contrast their measured cross-section ratio d{sigma}{parallel}/d{sigma}{perpendicular}, with expectations of earlier analyses, by the authors and Wittman (DMW), by Nozawa et al. (NBL), and using the multipoles of Behrends and Donnachie directly, and find {open_quotes}large discrepancies{close_quotes} among them. Here the authors clarify these discrepancies. The crucial difference between DMW and NBL calculations is the inclusion of the u-channel {Delta} contribution in DMW, omittedmore » in NBL. The authors find for a fair, though not perfect, agreement with the new data: E{sub 1+}{sup {pi}}{sup 0} {r_arrow}2.1E{sub 1+}{sup {pi}}{sup 0}, keeping other multipoles fixed.« less

  20. 44 CFR 332.2 - Developing voluntary agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Developing voluntary agreements. 332.2 Section 332.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS VOLUNTARY AGREEMENTS UNDER SECTION 708 OF THE DEFENSE PRODUCTION...

  1. 44 CFR 332.2 - Developing voluntary agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Developing voluntary agreements. 332.2 Section 332.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS VOLUNTARY AGREEMENTS UNDER SECTION 708 OF THE DEFENSE PRODUCTION...

  2. 44 CFR 332.2 - Developing voluntary agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Developing voluntary agreements. 332.2 Section 332.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS VOLUNTARY AGREEMENTS UNDER SECTION 708 OF THE DEFENSE PRODUCTION...

  3. 44 CFR 332.2 - Developing voluntary agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Developing voluntary agreements. 332.2 Section 332.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS VOLUNTARY AGREEMENTS UNDER SECTION 708 OF THE DEFENSE PRODUCTION...

  4. 44 CFR 332.2 - Developing voluntary agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Developing voluntary agreements. 332.2 Section 332.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS VOLUNTARY AGREEMENTS UNDER SECTION 708 OF THE DEFENSE PRODUCTION...

  5. 40 CFR 35.6205 - Removal Cooperative Agreements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Removal Cooperative Agreements. 35.6205 Section 35.6205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund...

  6. 40 CFR 35.6205 - Removal Cooperative Agreements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Removal Cooperative Agreements. 35.6205 Section 35.6205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund...

  7. 40 CFR 35.6205 - Removal Cooperative Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Removal Cooperative Agreements. 35.6205 Section 35.6205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund...

  8. PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.

    PubMed

    Malek, Mouhannad; Kielkowska, Anna; Chessa, Tamara; Anderson, Karen E; Barneda, David; Pir, Pınar; Nakanishi, Hiroki; Eguchi, Satoshi; Koizumi, Atsushi; Sasaki, Junko; Juvin, Véronique; Kiselev, Vladimir Y; Niewczas, Izabella; Gray, Alexander; Valayer, Alexandre; Spensberger, Dominik; Imbert, Marine; Felisbino, Sergio; Habuchi, Tomonori; Beinke, Soren; Cosulich, Sabina; Le Novère, Nicolas; Sasaki, Takehiko; Clark, Jonathan; Hawkins, Phillip T; Stephens, Len R

    2017-11-02

    The PI3K signaling pathway regulates cell growth and movement and is heavily mutated in cancer. Class I PI3Ks synthesize the lipid messenger PI(3,4,5)P 3 . PI(3,4,5)P 3 can be dephosphorylated by 3- or 5-phosphatases, the latter producing PI(3,4)P 2 . The PTEN tumor suppressor is thought to function primarily as a PI(3,4,5)P 3 3-phosphatase, limiting activation of this pathway. Here we show that PTEN also functions as a PI(3,4)P 2 3-phosphatase, both in vitro and in vivo. PTEN is a major PI(3,4)P 2 phosphatase in Mcf10a cytosol, and loss of PTEN and INPP4B, a known PI(3,4)P 2 4-phosphatase, leads to synergistic accumulation of PI(3,4)P 2 , which correlated with increased invadopodia in epidermal growth factor (EGF)-stimulated cells. PTEN deletion increased PI(3,4)P 2 levels in a mouse model of prostate cancer, and it inversely correlated with PI(3,4)P 2 levels across several EGF-stimulated prostate and breast cancer lines. These results point to a role for PI(3,4)P 2 in the phenotype caused by loss-of-function mutations or deletions in PTEN. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  9. 77 FR 67814 - Proposed Settlement Agreement, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-14

    ... Suit AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of proposed settlement agreement..., 2012, Sierra Club (``Intervenor'') filed a timely motion to intervene. The motion was granted March 27, 2012. The proposed settlement agreement establishes a deadline for EPA to take action on a SIP to be...

  10. Exclusive Central $$\\pi^{+}\\pi^{-}$$ Production in Proton Antiproton Collisions at the CDF

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zurek, Maria

    Exclusivemore » $$\\pi^{=}\\pi^{-}$$ production in proton-antiproton collisions at $$\\sqrt{s}$$ = 0.9 and 1.96 TeV in the Collider Detector at Fermilab has been measured. We select events with two particles with opposite charge in pseudorapidity region -1.3 < $$\\eta$$ < 1.3 with no other particles detected in -5.9 < $$\\eta$$ < 5.9. Particles are assumed to be pions. The $$\\pi^{+}\\pi^{-}$$system is required to have rapidity -1.0 < $y$ < 1.0. The data are expected to be dominated by the double pomeron exchange mechanism. Therefore, the quantum numbers of the central state are constrained. The data extend up to dipion mass M($$\\pi^{+}\\pi^{-}$$) = 5000 MeV/$c^2$. Resonance structures consistent with $$f_0$$ and $$f_2$$(1270) mesons are visible. The results are valuable for light hadron spectroscopy and for providing information about the nature of the pomeron in a region between non-perturbative and perturbative quantum chromodynamics« less

  11. HOW DO THE CITIZENS EVALUATE PUBLIC AGENCY REPRESENTATIVE'S COMMUNICATION?

    NASA Astrophysics Data System (ADS)

    Hyuga, Nami; Terabe, Shintaro

    A public involvement (PI) process recently introduced into road planning and various infrastructure planning processes requires that public agency re presentative communicate with the public about planning information. Although many public and open house meetings are led by trained consultants and facilitators, public agency representative also frequently have the opportunity to communicate directly with citizens at such events. However, du e to a lack of communication traini ng, they may not be able to communicate ideas clearly to citizens. In this study, the authors analyzed the nature of public agency representative responses to citizen questions typically asked at a public meeting. As a result of this study, "good manner" was judged to be the most influen tial factor for a good evaluation by citizens and the presence or absence of the "technical terms" was judged to be the second most influential factor for citizens behind "good manner".Thus, public agency representative should convey information to citizens in a "good manner" and without using "technical terms" as described herein so as to discuss issues clearly. The findings of this study will promote better communication with citizens engaged in PI.

  12. Measuring the charged pion polarizability in the gamma gamma -> pi+pi- reaction

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lawrence, David W.; Miskimen, Rory A.; Mushkarenkov, Alexander Nikolaevich

    2013-08-01

    Development has begun of a new experiment to measure the charged pion polarizabilitymore » $$\\alpha_{\\pi}-\\beta_{\\pi}$$. The charged pion polarizability ranks among the most important tests of low-energy QCD presently unresolved by experiment. Analogous to precision measurements of $$\\pi^{\\circ}\\rightarrow\\gamma\\gamma$$ that test the intrinsic odd-parity (anomalous) sector of QCD, the pion polarizability tests the intrinsic even-parity sector of QCD. The measurement will be performed using the $$\\gamma\\gamma\\rightarrow\\pi^{+{}}\\pi^{-{}}$$ cross section accessed via the Primakoff mechanism on nuclear targets using the GlueX detector in Hall D at Jefferson Lab. The linearly polarized photon source in Hall-D will be utilized to separate the Primakoff cross-section from coherent $$\\rho^{\\circ}$$ production.« less

  13. 2 CFR 176.20 - Agency responsibilities (general).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Agency responsibilities (general). 176.20 Section 176.20 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS... appropriate enforcement or termination action in accordance with 2 CFR 215.62 or the agency's implementation...

  14. 2 CFR 220.30 - Federal Agency responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Federal Agency responsibilities. 220.30 Section 220.30 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE Reserved COST PRINCIPLES FOR EDUCATIONAL INSTITUTIONS (OMB CIRCULAR A-21) § 220.30 Federal Agency responsibilities. The...

  15. 48 CFR 536.271 - Project labor agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... facilities to be owned by a Federal department or agency. You may use a PLA in leasehold arrangement... than $5 million. Project Labor Agreement (PLA) means an agreement between the contractor, subcontractors, and the union(s) representing workers. Under a PLA, the contractor and subcontractors on a...

  16. 44 CFR 332.4 - Termination or modifying voluntary agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS VOLUNTARY AGREEMENTS UNDER SECTION 708 OF THE DEFENSE PRODUCTION ACT OF 1950, AS AMENDED § 332.4 Termination or modifying voluntary agreements. The...

  17. 44 CFR 332.4 - Termination or modifying voluntary agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS VOLUNTARY AGREEMENTS UNDER SECTION 708 OF THE DEFENSE PRODUCTION ACT OF 1950, AS AMENDED § 332.4 Termination or modifying voluntary agreements. The...

  18. 44 CFR 332.4 - Termination or modifying voluntary agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS VOLUNTARY AGREEMENTS UNDER SECTION 708 OF THE DEFENSE PRODUCTION ACT OF 1950, AS AMENDED § 332.4 Termination or modifying voluntary agreements. The...

  19. 44 CFR 332.4 - Termination or modifying voluntary agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS VOLUNTARY AGREEMENTS UNDER SECTION 708 OF THE DEFENSE PRODUCTION ACT OF 1950, AS AMENDED § 332.4 Termination or modifying voluntary agreements. The...

  20. 44 CFR 332.4 - Termination or modifying voluntary agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS VOLUNTARY AGREEMENTS UNDER SECTION 708 OF THE DEFENSE PRODUCTION ACT OF 1950, AS AMENDED § 332.4 Termination or modifying voluntary agreements. The...

  1. The Quest for Pi

    NASA Technical Reports Server (NTRS)

    Bailey, David H.; Borwein, Jonathan M.; Borwein, Peter B.; Plouffe, Simon

    1996-01-01

    This article gives a brief history of the analysis and computation of the mathematical constant Pi=3.14159 ..., including a number of the formulas that have been used to compute Pi through the ages. Recent developments in this area are then discussed in some detail, including the recent computation of Pi to over six billion decimal digits using high-order convergent algorithms, and a newly discovered scheme that permits arbitrary individual hexadecimal digits of Pi to be computed.

  2. Α₁-antitrypsin PiMZ heterozygosity has an independent aggravating effect on liver fibrosis in alcoholic liver disease.

    PubMed

    Goltz, Diane; Hittetiya, Kanishka; Vössing, Lena Marie; Kirfel, Jutta; Spengler, Ulrich; Fischer, Hans-Peter

    2014-11-01

    Heterozygous α1-antitrypsin deficiency type PiZ (PiMZ) results in chronic liver injury and predisposes to hepatocellular carcinoma. Gene frequency of the PiZ allele ranges from 0.005 to 0.027 in Western and Central Europe; therefore, there is a substantial risk of coincidence with chronic alcohol abuse. This retrospective case-control study evaluates the impact of PiMZ genotype on the development of chronic liver disease in alcohol consuming patients. Six thousand eight hundred eighty-six consecutive liver specimens were immunohistochemically tested for PiZ-deposits. From 254 PiZ-positive patients, the liver biopsies of 30 PiMZ adults without concomitant liver disease other than alcoholic liver disease (ALD) were selected and matched to PiMM (wild type) patients with respect to age, gender and lifetime daily alcohol ingestion (LDAI). Histomorphological changes were assessed using the SAF score and by digital image analysis. Liver cirrhosis was significantly more frequent in PIMZ patients than in matched PiMM patients (PiMM 9/30 vs. PiMZ 14/30, p = 0.04). Comparison of the extent of fibrosis in PiMZ and PiMM livers by two-way ANOVA indicated that the amount of LDAI has a major effect in PiMZ and PiMM patients (30.04 % of total variation, p < 0.0001), whereas PIMZ genotype has a minor but independent effect on liver fibrosis as assessed by digital planimetric evaluation (9.27 % of total variation, p = 0.005). Semiquantitative assessment was in agreement with this finding. Histomorphological findings support that PiMZ heterozygosity has an independent aggravating effect on liver fibrosis, even though the pathogenic effect of alcohol consumption is much stronger.

  3. 7 CFR 210.9 - Agreement with State agency.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... who are determined by the local educational agency to be eligible for such meals under 7 CFR part 245... authority official signing the claim shall be responsible for reviewing and analyzing meal counts to ensure... reimbursable meals served to eligible children at the point of service, or through another counting system if...

  4. 7 CFR 210.9 - Agreement with State agency.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...; (iii) The child is a runaway child as defined in § 245.2 of this chapter; (iv) The child is a migrant... AGRICULTURE CHILD NUTRITION PROGRAMS NATIONAL SCHOOL LUNCH PROGRAM Requirements for School Food Authority... combination of the Child Nutrition Programs, that State agency shall provide each school food authority with a...

  5. 7 CFR 210.9 - Agreement with State agency.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...; (iii) The child is a runaway child as defined in § 245.2 of this chapter; (iv) The child is a migrant... AGRICULTURE CHILD NUTRITION PROGRAMS NATIONAL SCHOOL LUNCH PROGRAM Requirements for School Food Authority... combination of the Child Nutrition Programs, that State agency shall provide each school food authority with a...

  6. 7 CFR 210.9 - Agreement with State agency.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...; (iii) The child is a runaway child as defined in § 245.2 of this chapter; (iv) The child is a migrant... AGRICULTURE CHILD NUTRITION PROGRAMS NATIONAL SCHOOL LUNCH PROGRAM Requirements for School Food Authority... combination of the Child Nutrition Programs, that State agency shall provide each school food authority with a...

  7. Dipion invariant mass distribution of the anomalous {Upsilon}(1S){pi}{sup +}{pi}{sup -} and {Upsilon}(2S){pi}{sup +}{pi}{sup -} production near the peak of {Upsilon}(10860)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chen Dianyong; He Jun; Nuclear Theory Group, Institute of Modern Physics of CAS, Lanzhou 730000

    2011-10-01

    Considering the defects of the previous work for estimating the anomalous production rates of e{sup +}e{sup -}{yields}{Upsilon}(1S){pi}{sup +}{pi}{sup -}, {Upsilon}(2S){pi}{sup +}{pi}{sup -} near the peak of the {Upsilon}(5S) resonance at {radical}(s)=10.87 GeV [K. F. Chen et al. (Belle Collaboration), Phys. Rev. Lett. 100, 112001 (2008)], we suggest a new scenario where the contributions from the direct dipion transition and the final-state interactions interfere to result in not only the anomalously large production rates, but also line shapes of the differential widths consistent with experimental measurement when assuming the reactions are due to the dipion emission of {Upsilon}(5S). At the end,more » we raise a new puzzle that the predicted differential width d{Gamma}({Upsilon}(5S){yields}{Upsilon}(2S){pi}{sup +}{pi}{sup -})/dcos{theta} has a discrepant trend from the data while other predictions are well in accord with the data. It should be further clarified by more accurate measurements carried by future experiments.« less

  8. 7 CFR 1956.96 - Delinquent adjustment agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE...-Family Housing § 1956.96 Delinquent adjustment agreements. A 90-day extension for making the payments may be given by the Agency when the circumstances of the case justify an extension. A decision not to...

  9. 22 CFR 181.5 - Twenty-day rule for concluded agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Twenty-day rule for concluded agreements. 181.5 Section 181.5 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL AGREEMENTS COORDINATION, REPORTING AND PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.5 Twenty-day rule for concluded agreements. (a) Any agency...

  10. The impact of new polarization data from Bonn, Mainz and Jefferson Laboratory on $$\\gamma p \\rightarrow \\pi N$$ multipoles

    DOE PAGES

    Anisovich, A. V.; Beck, R.; Döring, M.; ...

    2016-09-16

    New data on pion-photoproduction off the proton have been included in the partial wave analyses Bonn-Gatchina and SAID and in the dynamical coupled-channel approach Julich-Bonn. All reproduce the recent new data well: the double polarization data for E, G, H, P and T inmore » $$\\gamma p \\to \\pi^0 p$$ from ELSA, the beam asymmetry $$\\Sigma$$ for $$\\gamma p \\to \\pi^0 p$$ and $$\\pi^+ n$$ from Jefferson Laboratory, and the precise new differential cross section and beam asymmetry data $$\\Sigma$$ for $$\\gamma p \\to \\pi^0 p$$ from MAMI. The new fit results for the multipoles are compared with predictions not taking into account the new data. Lastly, the mutual agreement is improved considerably but still far from being perfect.« less

  11. The impact of new polarization data from Bonn, Mainz and Jefferson Laboratory on $$\\gamma p \\rightarrow \\pi N$$ multipoles

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Anisovich, A. V.; Beck, R.; Döring, M.

    New data on pion-photoproduction off the proton have been included in the partial wave analyses Bonn-Gatchina and SAID and in the dynamical coupled-channel approach Julich-Bonn. All reproduce the recent new data well: the double polarization data for E, G, H, P and T inmore » $$\\gamma p \\to \\pi^0 p$$ from ELSA, the beam asymmetry $$\\Sigma$$ for $$\\gamma p \\to \\pi^0 p$$ and $$\\pi^+ n$$ from Jefferson Laboratory, and the precise new differential cross section and beam asymmetry data $$\\Sigma$$ for $$\\gamma p \\to \\pi^0 p$$ from MAMI. The new fit results for the multipoles are compared with predictions not taking into account the new data. Lastly, the mutual agreement is improved considerably but still far from being perfect.« less

  12. 22 CFR 221.32 - Change in agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Change in agreements. 221.32 Section 221.32 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Covenants § 221.32 Change in agreements. No Noteholder will consent to any change or waiver of any provision...

  13. 22 CFR 221.32 - Change in agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Change in agreements. 221.32 Section 221.32 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Covenants § 221.32 Change in agreements. No Noteholder will consent to any change or waiver of any provision...

  14. 22 CFR 221.32 - Change in agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Change in agreements. 221.32 Section 221.32 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Covenants § 221.32 Change in agreements. No Noteholder will consent to any change or waiver of any provision...

  15. 22 CFR 221.32 - Change in agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Change in agreements. 221.32 Section 221.32 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Covenants § 221.32 Change in agreements. No Noteholder will consent to any change or waiver of any provision...

  16. 22 CFR 221.32 - Change in agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Change in agreements. 221.32 Section 221.32 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Covenants § 221.32 Change in agreements. No Noteholder will consent to any change or waiver of any provision...

  17. 5 CFR 575.111 - Termination of a service agreement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...., for unacceptable performance or conduct), if the employee receives a rating of record (or an official... management needs of the agency. For example, an agency may terminate a service agreement when the employee's... incentive payments, or when the agency assigns the employee to a different position (if the different...

  18. 5 CFR 575.211 - Termination of a service agreement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...., for unacceptable performance or conduct), if the employee receives a rating of record (or an official... needs of the agency. For example, an agency may terminate a service agreement when the employee's... incentive payments, or when the agency assigns the employee to a different position (if the different...

  19. The Copyright Agency Limited.

    ERIC Educational Resources Information Center

    Morgan, Caroline

    1993-01-01

    The evolution and functions of Australia's Copyright Agency Limited are described. The agency is a copyright collecting organization which collectively administers the rights of authors and publishers whose works are copied in education, and enters into blanket agreements with educational authorities outside the existing statutory license. Some…

  20. Pi Division and Addition

    ERIC Educational Resources Information Center

    Scott, Paul

    2008-01-01

    The number Pi (approximately 3.14159) is defined to be the ratio C/d of the circumference (C) to the diameter (d) of any given circle. In particular, Pi measures the circumference of a circle of diameter d = 1. Historically, the Greek mathematician Archimedes found good approximations for Pi by inscribing and circumscribing many-sided polygons…

  1. Observation and Study of the Baryonic B-meson Decays B to D(*) p pbar (pi) (pi)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    del Amo Sanchez, P.; Lees, J.P.; Poireau, V.

    We present results for B-meson decay modes involving a charm meson, protons, and pions using 455 x 10{sup 6} B{bar B} pairs recorded by the BABAR detector at the SLAC PEP-II asymmetric-energy e{sup +}e{sup -} collider. The branching fractions are measured for the following ten decays: {bar B}{sup 0} {yields} D{sup 0}p{bar p}, {bar B}{sup 0} {yields} D*{sup 0}p{bar p}, {bar B}{sup 0} {yields} D{sup +}p{bar p}{pi}{sup -}, {bar B}{sup 0} {yields} D*{sup +}p{bar p}{pi}{sup -}, B{sup -} {yields} D{sup 0}p{bar p}{pi}{sup -}, B{sup -} {yields} D*{sup 0}pp{pi}{sup -}, {bar B}{sup 0} {yields} D{sup 0}p{bar p}{pi}{sup -}{pi}{sup +}, {bar B}{supmore » 0} {yields} D*{sup 0}p{bar p}{pi}{sup -}{pi}{sup +}, B{sup -} {yields} D{sup +}p{bar p}{pi}{sup -}{pi}{sup -}, and B{sup -} {yields} D*{sup +}p{bar p}{pi}{sup -}{pi}{sup -}. The four B{sup -} and the two five-body B{sup 0} modes are observed for the first time. The four-body modes are enhanced compared to the three- and the five-body modes. In the three-body modes, the M(p{bar p}) and M(D{sup (*)0}p) invariant mass distributions show enhancements near threshold values. In the four-body mode {bar B}{sup 0} {yields} D{sup +}p{bar p}{pi}{sup -}, the M(p{pi}{sup -}) distribution shows a narrow structure of unknown origin near 1.5GeV/c{sup 2}. The distributions for the five-body modes, in contrast to the others, are similar to the expectations from uniform phase-space predictions.« less

  2. 44 CFR 332.3 - Carrying out voluntary agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Carrying out voluntary agreements. 332.3 Section 332.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS VOLUNTARY AGREEMENTS UNDER SECTION 708 OF THE DEFENSE PRODUCTION...

  3. 44 CFR 332.3 - Carrying out voluntary agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Carrying out voluntary agreements. 332.3 Section 332.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS VOLUNTARY AGREEMENTS UNDER SECTION 708 OF THE DEFENSE PRODUCTION...

  4. 44 CFR 332.3 - Carrying out voluntary agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Carrying out voluntary agreements. 332.3 Section 332.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS VOLUNTARY AGREEMENTS UNDER SECTION 708 OF THE DEFENSE PRODUCTION...

  5. 44 CFR 332.3 - Carrying out voluntary agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Carrying out voluntary agreements. 332.3 Section 332.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS VOLUNTARY AGREEMENTS UNDER SECTION 708 OF THE DEFENSE PRODUCTION...

  6. 44 CFR 332.3 - Carrying out voluntary agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Carrying out voluntary agreements. 332.3 Section 332.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS VOLUNTARY AGREEMENTS UNDER SECTION 708 OF THE DEFENSE PRODUCTION...

  7. 14 CFR 1274.213 - Distribution of cooperative agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Distribution of cooperative agreements... COOPERATIVE AGREEMENTS WITH COMMERCIAL FIRMS Pre-Award Requirements § 1274.213 Distribution of cooperative... functions are delegated to DOD or another agency), NASA Center for Aerospace Information (CASI), Attn...

  8. Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941.

    PubMed

    Raynaud, Florence I; Eccles, Suzanne A; Patel, Sonal; Alix, Sonia; Box, Gary; Chuckowree, Irina; Folkes, Adrian; Gowan, Sharon; De Haven Brandon, Alexis; Di Stefano, Francesca; Hayes, Angela; Henley, Alan T; Lensun, Letitia; Pergl-Wilson, Giles; Robson, Anthony; Saghir, Nahid; Zhyvoloup, Alexander; McDonald, Edward; Sheldrake, Peter; Shuttleworth, Stephen; Valenti, Melanie; Wan, Nan Chi; Clarke, Paul A; Workman, Paul

    2009-07-01

    The phosphatidylinositide 3-kinase pathway is frequently deregulated in human cancers and inhibitors offer considerable therapeutic potential. We previously described the promising tricyclic pyridofuropyrimidine lead and chemical tool compound PI-103. We now report the properties of the pharmaceutically optimized bicyclic thienopyrimidine derivatives PI-540 and PI-620 and the resulting clinical development candidate GDC-0941. All four compounds inhibited phosphatidylinositide 3-kinase p110alpha with IC(50) < or = 10 nmol/L. Despite some differences in isoform selectivity, these agents exhibited similar in vitro antiproliferative properties to PI-103 in a panel of human cancer cell lines, with submicromolar potency in PTEN-negative U87MG human glioblastoma cells and comparable phosphatidylinositide 3-kinase pathway modulation. PI-540 and PI-620 exhibited improvements in solubility and metabolism with high tissue distribution in mice. Both compounds gave improved antitumor efficacy over PI-103, following i.p. dosing in U87MG glioblastoma tumor xenografts in athymic mice, with treated/control values of 34% (66% inhibition) and 27% (73% inhibition) for PI-540 (50 mg/kg b.i.d.) and PI-620 (25 mg/kg b.i.d.), respectively. GDC-0941 showed comparable in vitro antitumor activity to PI-103, PI-540, and PI-620 and exhibited 78% oral bioavailability in mice, with tumor exposure above 50% antiproliferative concentrations for >8 hours following 150 mg/kg p.o. and sustained phosphatidylinositide 3-kinase pathway inhibition. These properties led to excellent dose-dependent oral antitumor activity, with daily p.o. dosing at 150 mg/kg achieving 98% and 80% growth inhibition of U87MG glioblastoma and IGROV-1 ovarian cancer xenografts, respectively. Together, these data support the development of GDC-0941 as a potent, orally bioavailable inhibitor of phosphatidylinositide 3-kinase. GDC-0941 has recently entered phase I clinical trials.

  9. Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

    PubMed Central

    Raynaud, Florence I.; Eccles, Suzanne A.; Patel, Sonal; Alix, Sonia; Box, Gary; Chuckowree, Irina; Folkes, Adrian; Gowan, Sharon; De Haven Brandon, Alexis; Di Stefano, Francesca; Hayes, Angela; Henley, Alan T.; Lensun, Letitia; Pergl-Wilson, Giles; Robson, Anthony; Saghir, Nahid; Zhyvoloup, Alexander; McDonald, Edward; Sheldrake, Peter; Shuttleworth, Stephen; Valenti, Melanie; Wan, Nan Chi; Clarke, Paul A.; Workman, Paul

    2009-01-01

    The phosphatidylinositide 3-kinase pathway is frequently deregulated in human cancers and inhibitors offer considerable therapeutic potential. We previously described the promising tricyclic pyridofuropyrimidine lead and chemical tool compound PI-103. We now report the properties of the pharmaceutically optimized bicyclic thienopyrimidine derivatives PI-540 and PI-620 and the resulting clinical development candidate GDC-0941. All four compounds inhibited phosphatidylinositide 3-kinase p110α with IC50 ≤ 10 nmol/L. Despite some differences in isoform selectivity, these agents exhibited similar in vitro antiproliferative properties to PI-103 in a panel of human cancer cell lines, with submicromolar potency in PTEN-negative U87MG human glioblastoma cells and comparable phosphatidylinositide 3-kinase pathway modulation. PI-540 and PI-620 exhibited improvements in solubility and metabolism with high tissue distribution in mice. Both compounds gave improved antitumor efficacy over PI-103, following i.p. dosing in U87MG glioblastoma tumor xenografts in athymic mice, with treated/control values of 34% (66% inhibition) and 27% (73% inhibition) for PI-540 (50 mg/kg b.i.d.) and PI-620 (25 mg/kg b.i.d.), respectively. GDC-0941 showed comparable in vitro antitumor activity to PI-103, PI-540, and PI-620 and exhibited 78% oral bioavailability in mice, with tumor exposure above 50% anti-proliferative concentrations for >8 hours following 150 mg/kg p.o. and sustained phosphatidylinositide 3-kinase pathway inhibition. These properties led to excellent dose-dependent oral antitumor activity, with daily p.o. dosing at 150 mg/kg achieving 98% and 80% growth inhibition of U87MG glioblastoma and IGROV-1 ovarian cancer xenografts, respectively. Together, these data support the development of GDC-0941 as a potent, orally bioavailable inhibitor of phosphatidylinositide 3-kinase. GDC-0941 has recently entered phase I clinical trials. PMID:19584227

  10. Nitrogen-Doping Enables Covalent-Like pi-pi Bonding between Graphenes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tian, Yong-Hui; Huang, Jingsong; Sumpter, Bobby G

    The neighboring layers in bi-layer (and few-layer) graphenes of both AA and AB stacking motifs are known to be separated at a distance corresponding to van der Waals (vdW) interactions. In this Letter, we present for the first time a new aspect of graphene chemistry in terms of a special chemical bonding between the giant graphene molecules . Through rigorous theoretical calculations, we demonstrate that the N-doped graphenes (NGPs) with various doping levels can form an unusual two-dimensional (2D) pi pi bonding in bi-layer NGPs bringing the neighboring NGPs to significantly reduced interlayer separations. The interlayer binding energies can bemore » enhanced by up to 50% compared to the pristine graphene bi-layers that are characterized by only vdW interactions. Such an unusual chemical bonding arises from the pi pi overlap across the vdW gap while the individual layers maintain their in-plane pi-conjugation and are accordingly planar. The existence of the resulting interlayer covalent-like bonding is corroborated by electronic structure calculations and crystal orbital overlap population (COOP) analyses. In NGP-based graphite with the optimal doping level, the NGP layers are uniformly stacked and the 3D bulk exhibits metallic characteristics both in the in-plane and along the stacking directions.« less

  11. 48 CFR 1542.1202 - Responsibility for executing agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PROTECTION AGENCY CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Novation and Change of Name Agreements 1542... successor in interest to, or change of name of, one of its Contractors shall promptly report such... recognize a change of name or successor in interest, only one supplemental agreement will be prepared to...

  12. 48 CFR 1542.1202 - Responsibility for executing agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... PROTECTION AGENCY CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Novation and Change of Name Agreements 1542... successor in interest to, or change of name of, one of its Contractors shall promptly report such... recognize a change of name or successor in interest, only one supplemental agreement will be prepared to...

  13. Measurement of branching fractions and charge asymmetries in B+/--->rho+/-pi0 and B+/--->rho0pi+/- decays, and search for B0-->rho0pi0.

    PubMed

    Aubert, B; Barate, R; Boutigny, D; Couderc, F; Gaillard, J-M; Hicheur, A; Karyotakis, Y; Lees, J P; Robbe, P; Tisserand, V; Zghiche, A; Palano, A; Pompili, A; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Borgland, A W; Breon, A B; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Day, C T; Gill, M S; Gritsan, A V; Groysman, Y; Jacobsen, R G; Kadel, R W; Kadyk, J; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; LeClerc, C; Levi, M E; Lynch, G; Mir, L M; Oddone, P J; Orimoto, T J; Pripstein, M; Roe, N A; Romosan, A; Ronan, M T; Shelkov, V G; Telnov, A V; Wenzel, W A; Ford, K; Harrison, T J; Hawkes, C M; Knowles, D J; Morgan, S E; Penny, R C; Watson, A T; Watson, N K; Goetzen, K; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schmuecker, H; Steinke, M; Boyd, J T; Chevalier, N; Cottingham, W N; Kelly, M P; Latham, T E; Mackay, C; Wilson, F F; Abe, K; Cuhadar-Donszelmann, T; Hearty, C; Mattison, T S; McKenna, J A; Thiessen, D; Kyberd, P; McKemey, A K; Teodorescu, L; Blinov, V E; Bukin, A D; Golubev, V B; Ivanchenko, V N; Kravchenko, E A; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Yushkov, A N; Best, D; Bruinsma, M; Chao, M; Kirkby, D; Lankford, A J; Mandelkern, M; Mommsen, R K; Roethel, W; Stoker, D P; Buchanan, C; Hartfiel, B L; Gary, J W; Layter, J; Shen, B C; Wang, K; del Re, D; Hadavand, H K; Hill, E J; MacFarlane, D B; Paar, H P; Rahatlou, Sh; Sharma, V; Berryhill, J W; Campagnari, C; Dahmes, B; Levy, S L; Long, O; Lu, A; Mazur, M A; Richman, J D; Verkerke, W; Beck, T W; Beringer, J; Eisner, A M; Heusch, C A; Lockman, W S; Schalk, T; Schmitz, R E; Schumm, B A; Seiden, A; Spradlin, P; Turri, M; Walkowiak, W; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dubois-Felsmann, G P; Dvoretskii, A; Erwin, R J; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Ryd, A; Samuel, A; Yang, S; Jayatilleke, S; Mancinelli, G; Meadows, B T; Sokoloff, M D; Abe, T; Blanc, F; Bloom, P; Chen, S; Clark, P J; Ford, W T; Nauenberg, U; Olivas, A; Rankin, P; Roy, J; Smith, J G; van Hoek, W C; Zhang, L; Harton, J L; Hu, T; Soffer, A; Toki, W H; Wilson, R J; Zhang, J; Altenburg, D; Brandt, T; Brose, J; Colberg, T; Dickopp, M; Dubitzky, R S; Hauke, A; Lacker, H M; Maly, E; Müller-Pfefferkorn, R; Nogowski, R; Otto, S; Schubert, J; Schubert, K R; Schwierz, R; Spaan, B; Wilden, L; Bernard, D; Bonneaud, G R; Brochard, F; Cohen-Tanugi, J; Grenier, P; Thiebaux, Ch; Vasileiadis, G; Verderi, M; Khan, A; Lavin, D; Muheim, F; Playfer, S; Swain, J E; Andreotti, M; Azzolini, V; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Piemontese, L; Sarti, A; Treadwell, E; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Falciai, D; Finocchiaro, G; Patteri, P; Piccolo, M; Zallo, A; Buzzo, A; Capra, R; Contri, R; Crosetti, G; Lo Vetere, M; Macri, M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Bailey, S; Morii, M; Won, E; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Eschrich, I; Gaillard, J R; Morton, G W; Nash, J A; Taylor, G P; Grenier, G J; Lee, S-J; Mallik, U; Cochran, J; Crawley, H B; Lamsa, J; Meyer, W T; Prell, S; Rosenberg, E I; Yi, J; Davier, M; Grosdidier, G; Höcker, A; Laplace, S; Le Diberder, F; Lepeltier, V; Lutz, A M; Petersen, T C; Plaszczynski, S; Schune, M H; Tantot, L; Wormser, G; Brigljević, V; Cheng, C H; Lange, D J; Simani, M C; Wright, D M; Bevan, A J; Coleman, J P; Fry, J R; Gabathuler, E; Gamet, R; Kay, M; Parry, R J; Payne, D J; Sloane, R J; Touramanis, C; Back, J J; Harrison, P F; Shorthouse, H W; Vidal, P B; Brown, C L; Cowan, G; Flack, R L; Flaecher, H U; George, S; Green, M G; Kurup, A; Marker, C E; McMahon, T R; Ricciardi, S; Salvatore, F; Vaitsas, G; Winter, M A; Brown, D; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Hart, P A; Hodgkinson, M C; Jackson, F; Lafferty, G D; Lyon, A J; Weatherall, J H; Williams, J C; Farbin, A; Jawahery, A; Kovalskyi, D; Lae, C K; Lillard, V; Roberts, D A; Blaylock, G; Dallapiccola, C; Flood, K T; Hertzbach, S S; Kofler, R; Koptchev, V B; Moore, T B; Saremi, S; Staengle, H; Willocq, S; Cowan, R; Sciolla, G; Taylor, F; Yamamoto, R K; Mangeol, D J J; Patel, P M; Robertson, S H; Lazzaro, A; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Reidy, J; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Cote-Ahern, D; Taras, P; Nicholson, H; Cartaro, C; Cavallo, N; De Nardo, G; Fabozzi, F; Gatto, C; Lista, L; Paolucci, P; Piccolo, D; Sciacca, C; Baak, M A; Raven, G; LoSecco, J M; Gabriel, T A; Brau, B; Gan, K K; Honscheid, K; Hufnagel, D; Kagan, H; Kass, R; Pulliam, T; Wong, Q K; Brau, J; Frey, R; Igonkina, O; Potter, C T; Sinev, N B; Strom, D; Torrence, E; Colecchia, F; Dorigo, A; Galeazzi, F; Margoni, M; Morandin, M; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Tiozzo, G; Voci, C; Benayoun, M; Briand, H; Chauveau, J; David, P; de la Vaissière, Ch; Del Buono, L; Hamon, O; John, M J J; Leruste, Ph; Ocariz, J; Pivk, M; Roos, L; Stark, J; T'Jampens, S; Therin, G; Manfredi, P F; Re, V; Behera, P K; Gladney, L; Guo, Q H; Panetta, J; Anulli, F; Biasini, M; Peruzzi, I M; Pioppi, M; Angelini, C; Batignani, G; Bettarini, S; Bondioli, M; Bucci, F; Calderini, G; Carpinelli, M; Del Gamba, V; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Martinez-Vidal, F; Morganti, M; Neri, N; Paoloni, E; Rama, M; Rizzo, G; Sandrelli, F; Walsh, J; Haire, M; Judd, D; Paick, K; Wagoner, D E; Danielson, N; Elmer, P; Lu, C; Miftakov, V; Olsen, J; Smith, A J S; Tanaka, H A; Varnes, E W; Bellini, F; Cavoto, G; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Mazzoni, M A; Morganti, S; Pierini, M; Piredda, G; Safai Tehrani, F; Voena, C; Christ, S; Wagner, G; Waldi, R; Adye, T; De Groot, N; Franek, B; Geddes, N I; Gopal, G P; Olaiya, E O; Xella, S M; Aleksan, R; Emery, S; Gaidot, A; Ganzhur, S F; Giraud, P-F; Hamel de Monchenault, G; Kozanecki, W; Langer, M; Legendre, M; London, G W; Mayer, B; Schott, G; Vasseur, G; Yeche, Ch; Zito, M; Purohit, M V; Weidemann, A W; Yumiceva, F X; Aston, D; Bartoldus, R; Berger, N; Boyarski, A M; Buchmueller, O L; Convery, M R; Cristinziani, M; Dong, D; Dorfan, J; Dujmic, D; Dunwoodie, W; Elsen, E E; Field, R C; Glanzman, T; Gowdy, S J; Grauges-Pous, E; Hadig, T; Halyo, V; Hast, C; Hryn'ova, T; Innes, W R; Jessop, C P; Kelsey, M H; Kim, P; Kocian, M L; Langenegger, U; Leith, D W G S; Libby, J; Luitz, S; Luth, V; Lynch, H L; Marsiske, H; Messner, R; Muller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Petrak, S; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Simi, G; Snyder, A; Soha, A; Stelzer, J; Su, D; Sullivan, M K; Va'vra, J; Wagner, S R; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wright, D H; Young, C C; Burchat, P R; Edwards, A J; Meyer, T I; Petersen, B A; Roat, C; Ahmed, M; Ahmed, S; Alam, M S; Ernst, J A; Saeed, M A; Saleem, M; Wappler, F R; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Kim, H; Ritchie, J L; Schwitters, R F; Izen, J M; Kitayama, I; Lou, X C; Ye, S; Bianchi, F; Bona, M; Gallo, F; Gamba, D; Borean, C; Bosisio, L; Della Ricca, G; Dittongo, S; Grancagnolo, S; Lanceri, L; Poropat, P; Vitale, L; Vuagnin, G; Panvini, R S; Banerjee, Sw; Brown, C M; Fortin, D; Jackson, P D; Kowalewski, R; Roney, J M; Band, H R; Dasu, S; Datta, M; Eichenbaum, A M; Johnson, J R; Kutter, P E; Li, H; Liu, R; Di Lodovico, F; Mihalyi, A; Mohapatra, A K; Pan, Y; Prepost, R; Sekula, S J; von Wimmersperg-Toeller, J H; Wu, J; Wu, S L; Yu, Z; Neal, H

    2004-07-30

    We present measurements of branching fractions and charge asymmetries in B-meson decays to rho(+)pi(0), rho(0)pi(+), and rho(0)pi(0). The data sample comprises 89x10(6) Upsilon(4S)-->BBmacr; decays collected with the BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC. We find the charge-averaged branching fractions B(B+-->rho(+)pi(0))=[10.9+/-1.9(stat)+/-1.9(syst)]x10(-6) and B(B+-->rho(0)pi(+))=(9.5+/-1.1+/-0.9)x10(-6), and we set a 90% confidence-level upper limit B(B0-->rho(0)pi(0))<2.9x10(-6). We measure the charge asymmetries ACP(pi(0))(rho(+))=0.24+/-0.16+/-0.06 and ACP(pi(+))(rho(0))=-0.19+/-0.11+/-0.02.

  14. First Observation of Charmed Resonances in the $$\\Lambda^0_b \\to \\Lambda^+_c \\pi^- \\pi^+ \\pi^-$$ Inclusive Decay and Measurement of Their Relative Branching Ratios at CDF

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barria, Patrizia

    2012-01-01

    We present the observation of themore » $$\\Lambda^0_b$$ decay into a $$\\Lambda^+_c \\pi^- \\pi^+ \\pi^-$$ final state, in $$p\\bar{p}$$ collisions at $$\\sqrt{s}$$ = 1:96 TeV. The data analyzed were collected by the CDF II detector at the Fermilab Tevatron collider, and correspond to 2:4 $$fb^{-1}$$ of integrated luminosity. We fit the invariant mass distribution of the reconstructed candidates to extract a signal yield of 848 $$\\pm$$ 93 $$\\Lambda^0_b$$ into $$\\Lambda^+_c \\pi^- \\pi^+ \\pi^-$$....« less

  15. 75 FR 47282 - Notice of Amendment No. 003 to the Solicitation for Cooperative Agreement Applications (SCAA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-05

    ... DEPARTMENT OF DEFENSE Defense Logistics Agency Notice of Amendment No. 003 to the Solicitation for Cooperative Agreement Applications (SCAA) Issued on May 5, 2009 AGENCY: Defense Logistics Agency, DOD. ACTION: Amended solicitation for cost sharing cooperative agreement applications. SUMMARY: The Defense Logistics...

  16. piRNA-guided slicing of transposon transcripts enforces their transcriptional silencing via specifying the nuclear piRNA repertoire.

    PubMed

    Senti, Kirsten-André; Jurczak, Daniel; Sachidanandam, Ravi; Brennecke, Julius

    2015-08-15

    PIWI clade Argonaute proteins silence transposon expression in animal gonads. Their target specificity is defined by bound ∼23- to 30-nucleotide (nt) PIWI-interacting RNAs (piRNAs) that are processed from single-stranded precursor transcripts via two distinct pathways. Primary piRNAs are defined by the endonuclease Zucchini, while biogenesis of secondary piRNAs depends on piRNA-guided transcript cleavage and results in piRNA amplification. Here, we analyze the interdependencies between these piRNA biogenesis pathways in developing Drosophila ovaries. We show that secondary piRNA-guided target slicing is the predominant mechanism that specifies transcripts—including those from piRNA clusters—as primary piRNA precursors and defines the spectrum of Piwi-bound piRNAs in germline cells. Post-transcriptional silencing in the cytoplasm therefore enforces nuclear transcriptional target silencing, which ensures the tight suppression of transposons during oogenesis. As target slicing also defines the nuclear piRNA pool during mouse spermatogenesis, our findings uncover an unexpected conceptual similarity between the mouse and fly piRNA pathways. © 2015 Senti et al.; Published by Cold Spring Harbor Laboratory Press.

  17. 2 CFR 1.210 - Applicability to Federal agencies and others.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Applicability to Federal agencies and others... Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction to Subtitle A § 1.210... officials; (2) Non-Federal entities that receive or apply for the agency's grants or agreements or receive...

  18. 2 CFR 1.210 - Applicability to Federal agencies and others.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Applicability to Federal agencies and others... Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction toSubtitle A § 1.210... officials; (2) Non-Federal entities that receive or apply for the agency's grants or agreements or receive...

  19. 2 CFR 1.210 - Applicability to Federal agencies and others.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Applicability to Federal agencies and others... Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction to Subtitle A § 1.210... officials; (2) Non-Federal entities that receive or apply for the agency's grants or agreements or receive...

  20. Alignment relaxation of Ne*(2pi [J = 1]) atoms in He-Ne* glow discharges

    NASA Astrophysics Data System (ADS)

    Bahrim, Cristian; Khadilkar, Vaibhav; Matsukuma, Hiraku; Hasuo, Masahiro

    2009-11-01

    Alignment relaxation of the Ne*(2p5 3p; 2pi [J = 1]) atoms (where i = 2, 5, 7 or 10) induced by collisions with He atoms in glow discharges at 77 K < T < 1,000 K are reported. Close-coupling many-channel quantum calculations using a model potential for the Ne*(2p5 3p) - He system are compared with measurements of the alignment relaxation using the LIFS technique and the Hanle effect. The addition of the dipole polarization potential of the Ne*(2pi [J = 1]) atoms to the spin-orbit coupling and the electrostatic interaction between Ne* and He atoms leads to good agreement between theory and experiment.

  1. A Simulation Study of Rater Agreement Measures with 2x2 Contingency Tables

    ERIC Educational Resources Information Center

    Ato, Manuel; Lopez, Juan Jose; Benavente, Ana

    2011-01-01

    A comparison between six rater agreement measures obtained using three different approaches was achieved by means of a simulation study. Rater coefficients suggested by Bennet's [sigma] (1954), Scott's [pi] (1955), Cohen's [kappa] (1960) and Gwet's [gamma] (2008) were selected to represent the classical, descriptive approach, [alpha] agreement…

  2. 78 FR 29672 - Small Generator Interconnection Agreements and Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-21

    ...] Small Generator Interconnection Agreements and Procedures AGENCY: Federal Energy Regulatory Commission... 7524). The regulations revised the pro forma Small Generator Interconnection Procedures (SGIP) and pro forma Small Generator Interconnection Agreement (SGIA) originally set forth in Order No. 2006. DATES...

  3. 20 CFR 625.18 - Public access to Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Public access to Agreements. 625.18 Section 625.18 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR DISASTER UNEMPLOYMENT ASSISTANCE § 625.18 Public access to Agreements. The State agency of a State will make available...

  4. CNES and NASA Agreements Signed

    NASA Image and Video Library

    2009-09-16

    French Space Agency President Yannick d’Escatha, left, and NASA Administrator Charles Bolden sign four agreements in support of U.S. and French space cooperation during a ceremony at NASA headquarters in Washington, Thursday, Sept. 17, 2009. Photo Credit: (NASA/Bill Ingalls)

  5. Slopes of $pi$-meson spectra in the K $Yields$ 3$pi$ decays (in Russian)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kapustnikov, A.A.

    1973-12-01

    The strong violation ( approximates 35%) of the rule DELTA T = 1/2 on the Dalitz piot for the K yields 3 pi decays is considered in the framework of the nonlinear realization of the chiral SU(2) x SU(2) symmetry. The Lagrangian without derivatives obtained previously is used to describe the contact weak K pi interaction. It is postulated that the enhancement of effects related to the electromagnetic mass differences of pi and K mesons in the K yields 3 pi amplitudes is due to the PCAC modification: partial delta A = constant pi (1 - 2 alpha lambda /supmore » 2/ KK). At alpha = 0.8 the predictions of the model are shown to coincide with the experiment. (auth)« less

  6. $$\\pi^0$$ Production with $K^-$ and $$\\pi^+$$ Beams at 530 GeV/c

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lanaro, Armando

    1990-01-01

    In thia theaia we report on measurements of inclusive neutral pion production at large transverse momenta (more » $$P_T$$) in collision of 530 GeV/c ($$\\sqrt{s}$$ = 31.5 GeV) $K^-$ and $$\\pi^+$$ beams with a copper and beryllium combined target. The $$\\pi^0$$ acceptance in center-of-mass rapidity is $$\\mid y \\mid$$ < 0.7, for $$P_T$$ values greater than 3.5 GeV/c (negative beam) and 4.25 GeV/c (positive beam). The data were taken using the large acceptance liquid argon calorimeter of the E706 spectrometer at Fermilab, and analyzed using the standard E706 reconstruction package. Ratios on $$\\pi^0$$ yields using $$\\pi^+, \\pi^-, K^-$$ and $p$ are presented. The results are used to examine issues of scaling in point-like hadronic collisions at high energies and large transverse momenta.« less

  7. 2 CFR 1.210 - Applicability to Federal agencies and others.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Applicability to Federal agencies and others... Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction toSubtitle A § 1.210... officials; (2) Non-Federal entities that receive or apply for the agency's grants or agreements or receive...

  8. UNITED STATES/GERMAN TECHNICAL BILATERAL AGREEMENT: PAST, PRESENT & FUTURE

    EPA Science Inventory

    The U.S. Environmental Protection Agency (EPA) and the German Federal Ministry of Education and Research (BMBF) entered into a Bilateral Agreement in 1990 to study each country's efforts in developing and demonstrating remedial technologies. The bilateral agreement is being impl...

  9. Combined Monte Carlo and quantum mechanics study of the solvatochromism of phenol in water. The origin of the blue shift of the lowest pi-pi* transition.

    PubMed

    Barreto, Rafael C; Coutinho, Kaline; Georg, Herbert C; Canuto, Sylvio

    2009-03-07

    A combined and sequential use of Monte Carlo simulations and quantum mechanical calculations is made to analyze the spectral shift of the lowest pi-pi* transition of phenol in water. The solute polarization is included using electrostatic embedded calculations at the MP2/aug-cc-pVDZ level giving a dipole moment of 2.25 D, corresponding to an increase of 76% compared to the calculated gas-phase value. Using statistically uncorrelated configurations sampled from the MC simulation, first-principle size-extensive calculations are performed to obtain the solvatochromic shift. Analysis is then made of the origin of the blue shift. Results both at the optimized geometry and in room-temperature liquid water show that hydrogen bonds of water with phenol promote a red shift when phenol is the proton-donor and a blue shift when phenol is the proton-acceptor. In the case of the optimized clusters the calculated shifts are in very good agreement with results obtained from mass-selected free jet expansion experiments. In the liquid case the contribution of the solute-solvent hydrogen bonds partially cancels and the total shift obtained is dominated by the contribution of the outer solvent water molecules. Our best result, including both inner and outer water molecules, is 570 +/- 35 cm(-1), in very good agreement with the small experimental shift of 460 cm(-1) for the absorption maximum.

  10. Study of a Narrow {pi}{sup +{pi}-} Peak at about 755 MeV/c{sup 2} in p-barn{yields}2{pi}{sup +}3{pi}{sup -} Annihilation at Rest

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gaspero, Mario

    2010-08-05

    A narrow peak in the {pi}{sup +{pi}-} mass distribution was seen by the Rome-Syracuse Collaboration in p-barn{yields}2{pi}{sup +}3{pi}{sup -} annihilation at rest in 1970. It was ignored for 40 years. The reanalysis of this peak finds that it has the mass 757.4{+-}2.8{sub stat{+-}}1.2{sub sys} MeV/c{sup 2} and a width consistent with the experimental resolution. The evidence of the peak is 5.2 standard deviations. The peak is generated in (1.03{+-}0.21{sub stat{+-}}0.21{sub sys})% of the p-barn annihilations at rest. No spin analysis is possible with the statistics of the experiment but there are arguments suggesting that it has J{sup p} = 0{supmore » +}.« less

  11. 48 CFR 742.770 - Negotiated indirect cost rate agreement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... rate agreement. 742.770 Section 742.770 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Indirect Cost Rates 742.770 Negotiated indirect cost... Agreement is automatically incorporated in each contract between the parties and shall specify: (a) The...

  12. 48 CFR 742.770 - Negotiated indirect cost rate agreement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... rate agreement. 742.770 Section 742.770 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Indirect Cost Rates 742.770 Negotiated indirect cost... Agreement is automatically incorporated in each contract between the parties and shall specify: (a) The...

  13. PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells.

    PubMed

    Li, Jiangmei; Gao, Zhen; Zhao, Dan; Zhang, Lunfeng; Qiao, Xinhua; Zhao, Yingying; Ding, Hong; Zhang, Panpan; Lu, Junyan; Liu, Jia; Jiang, Hualiang; Luo, Cheng; Chen, Chang

    2017-11-15

    While phosphatidylinositol 4-kinase (PI4KIIα) has been identified as a potential target for antitumor therapy, the clinical applications of PI4KIIα are limited by a lack of specific inhibitors. Here we report the first small-molecule inhibitor (SMI) of human PI4KIIα. Docking-based and ligand-based virtual screening strategies were first employed to identify promising hits, followed by two rounds of kinase activity inhibition validation. 2-(3-(4-Chlorobenzoyl)thioureido)-4-ethyl-5-methylthiophene-3-carboxamide (PI-273) exhibited the greatest inhibitory effect on PI4KIIα kinase activity (IC 50 = 0.47 μmol/L) and suppressed cell proliferation. Surface plasmon resonance and thermal shift assays indicated that PI-273 interacted directly with PI4KIIα. Kinetic analysis identified PI-273 as a reversible competitive inhibitor with respect to the substrate phosphatidylinositol (PI), which contrasted with most other PI kinase inhibitors that bind the ATP binding site. PI-273 reduced PI4P content, cell viability, and AKT signaling in wild-type MCF-7 cells, but not in PI4KIIα knockout MCF-7 cells, indicating that PI-273 is highly selective for PI4KIIα. Mutant analysis revealed a role of palmitoylation insertion in the selectivity of PI-273 for PI4KIIα. In addition, PI-273 treatment retarded cell proliferation by blocking cells in G 2 -M, inducing cell apoptosis and suppressing colony-forming ability. Importantly, PI-273 significantly inhibited MCF-7 cell-induced breast tumor growth without toxicity. PI-273 is the first substrate-competitive, subtype-specific inhibitor of PI4KIIα, the use of which will facilitate evaluations of PI4KIIα as a cancer therapeutic target. Cancer Res; 77(22); 6253-66. ©2017 AACR . ©2017 American Association for Cancer Research.

  14. A correlated ab initio study of the A2 pi <-- X2 sigma+ transition in MgCCH

    NASA Technical Reports Server (NTRS)

    Woon, D. E.

    1997-01-01

    The A2 pi <-- X2 sigma+ transition in MgCCH was studied with correlation consistent basis sets and single- and multireference correlation methods. The A2 pi excited state was characterized in detail; the x2 sigma+ ground state has been described elsewhere recently. The estimated complete basis set (CBS) limits for valence correlation, including zero-point energy corrections, are 22668, 23191, and 22795 for the RCCSD(T), MRCI, and MRCI + Q methods, respectively. A core-valence correction of +162 cm-1 shifts the RCCSD(T) value to 22830 cm-1, in good agreement with the experimental result of 22807 cm-1.

  15. ACHP | Nationwide Programmatic Agreements

    Science.gov Websites

    no longer in effect. The ACHP has notified each Federal agency with expired or superseded PAs of our findings. The list (below), Nationwide Programmatic Agreements In Effect as of March 2006, represents the remaining PAs, some of which were executed prior to revisions to the ACHP regulations that went into effect

  16. Dispersion relations with crossing symmetry for {pi}{pi}D- and F1-wave amplitudes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kaminski, R.

    Results of implementation of dispersion relations with imposed crossing symmetry condition to description of {pi}{pi}D and F1 wave amplitudes are presented. We use relations with only one subtraction what leads to small uncertainties of results and to strong constraints for tested {pi}{pi} amplitudes. Presented equations are similar to those with one subtraction (so called GKPY equations) and to those with two subtractions (the Roy's equations) for the S and P waves. Numerical calculations are done with the S and P wave input amplitudes tested already with use of the Roy's and GKPY equations.

  17. Unusual pi-donating effects of pi-accepting substituents on the stabilities of benzylic cations: a theoretical study.

    PubMed

    Kim, Chang Kon; Han, In Suk; Ryu, Wang Sun; Lee, Hai Whang; Lee, Bon-Su; Kim, Chan Kyung

    2006-02-23

    The pi-donating effects of pi-accepting X-substituents in substituted benzylic cations, X-C(6)H(5)-CHR(+) where R = CF(3), H and OCH(3), and X = p-NH(2), p-OCH(3), p-CH(3), H, p-F, p-Cl, p-CHO, m-CN, p-CN, m-NO(2) or p-NO(2), have been studied theoretically by using isodesmic hydride transfer reactions at various levels of theory. It might be difficult to determine the pi-donating effects of pi-acceptors using the simple Hammett-type linear equation, because it is not sensitive enough to include small pi-donating effects. Therefore, this effect was estimated using the NBO deletion energy (DeltaE(D)) of the second-order charge-transfer interaction (DeltaE(ct)) between the pi-orbitals (or lone pair orbitals) of the X-substituent and the pi-orbitals of phenyl ring. The extents of pi-donating effects increased in the order X = p-NO(2) < p-CHO < p-CN < p-Cl for both neutral and cationic species, and these effects were found to be more important for para- than for meta-substituents. Moreover, this could represent a general trend for pi-donation by pi-acceptors. On the other hand, the effects of R-substituents on this pi-donating effect were found to be in the order R = OCH(3) < H congruent with CF(3), as predicted by natural resonance theory (NRT) analyses.

  18. CNES and NASA Agreements Signed

    NASA Image and Video Library

    2009-09-16

    French Space Agency President Yannick d’Escatha, left, and NASA Administrator Charles Bolden shake hands after having signed four agreements in support of U.S. and French space cooperation during a ceremony at NASA headquarters in Washington, Thursday, Sept. 17, 2009. Photo Credit: (NASA/Bill Ingalls)

  19. Accurate ab initio calculations which demonstrate a 3 Pi u ground state for Al2

    NASA Technical Reports Server (NTRS)

    Bauschlicher, Charles W., Jr.; Partridge, Harry; Langhoff, Stephen R.; Taylor, Peter R.; Walch, Stephen P.

    1986-01-01

    The spectroscopic parameters and separations between the three low-lying X 3 Pi u, A 3 Sigma g -, and a 1 Sigma g + states of Al2 are studied as a function of both the one-particle and n-particle basis set. Approximate correlation treatments are calibrated against full Cl calculations correlating the six valence electrons in a double-zeta plus two d-function basis set. Since the CASSCF/MRCI 3 Pi u to 3 Sigma g - separation is in excellent agreement wtih the FCI value, the MRCI calculations were carried out in an extended (20s13p6d4f)/(6s5p3d2f) gaussian basis. Including a small correction for relativistic effects, the best estimate is that 3 Sigma g - state lies 174/cm above the 3 Pi u ground state. The 1 Sigma g + state lies at least 2000/cm higher in energy. At the CPF level, inclusion of 2s and 2p correlation has little effect on D sub e, reduces T sub e by only 26/cm, and shortens the bond lengths by about 0.02 a sub o. Further strong support for a 3 Pi u ground state comes from the experimental absorption spectra, since both observed transitions can be convincingly assigned as 3 Pi u yields 3 Pi g. The (2) 3 Pi g state is observed to be sensitive to the level of correlation treatment, and to have its minimum shifted to shorter rho values, such that the strongest experimental absorption peak probably corresponds to the 0 yields 2 transition.

  20. Pena to review LHC agreement

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lawler, A.

    The US government plans to review its tentative agreement with Europe to help build the Large Hadron Collider (LHC), to make sure it is a good deal for this country. The review, announced last week by Energy Secretary Federico Pena, comes at the urging of Representative James Sensenbrenner (RWI), who chairs the House Science Committee. Agency officials say they are confident that most of the lawmaker`s concerns can be met with only minor changes to the proposed partnership, while European managers insist that the current agreement already addresses most of Sensenbrenner`s worries.

  1. 2 CFR 180.620 - Do Federal agencies coordinate suspension and debarment actions?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Do Federal agencies coordinate suspension and debarment actions? 180.620 Section 180.620 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved OMB GUIDELINES TO AGENCIES ON GOVERNMENTWIDE DEBARMENT...

  2. PI(5)P Regulates Autophagosome Biogenesis

    PubMed Central

    Vicinanza, Mariella; Korolchuk, Viktor I.; Ashkenazi, Avraham; Puri, Claudia; Menzies, Fiona M.; Clarke, Jonathan H.; Rubinsztein, David C.

    2015-01-01

    Summary Phosphatidylinositol 3-phosphate (PI(3)P), the product of class III PI3K VPS34, recruits specific autophagic effectors, like WIPI2, during the initial steps of autophagosome biogenesis and thereby regulates canonical autophagy. However, mammalian cells can produce autophagosomes through enigmatic noncanonical VPS34-independent pathways. Here we show that PI(5)P can regulate autophagy via PI(3)P effectors and thereby identify a mechanistic explanation for forms of noncanonical autophagy. PI(5)P synthesis by the phosphatidylinositol 5-kinase PIKfyve was required for autophagosome biogenesis, and it increased levels of PI(5)P, stimulated autophagy, and reduced the levels of autophagic substrates. Inactivation of VPS34 impaired recruitment of WIPI2 and DFCP1 to autophagic precursors, reduced ATG5-ATG12 conjugation, and compromised autophagosome formation. However, these phenotypes were rescued by PI(5)P in VPS34-inactivated cells. These findings provide a mechanistic framework for alternative VPS34-independent autophagy-initiating pathways, like glucose starvation, and unravel a cytoplasmic function for PI(5)P, which previously has been linked predominantly to nuclear roles. PMID:25578879

  3. {pi}-{pi} Interactions and magnetic properties in a series of hybrid inorganic-organic crystals

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gonzalez, M.; Lemus-Santana, A.A.; Rodriguez-Hernandez, J.

    The series of hybrid inorganic-organic solids T(Im){sub 2}[Ni(CN){sub 4}] with T=Fe, Co, Ni and Im=imidazole were prepared by soft chemical routes from aqueous solutions of the involved building units: imidazole, T{sup 2+} metal and the [Ni(CN){sub 4}]{sup 2-} anionic block. The obtained samples were characterized from infrared and UV-vis spectroscopies, and thermogravimetric, X-ray diffraction and magnetic measurements. Anhydrous solids which crystallize with a monoclinic unit cell, in the I2/a space group with four formula units per cell (Z=4) were obtained. Their crystal structure was solved ab initio from the recorded X-ray powder patterns and then refined by the Rietveld method.more » The metal T is found with octahedral coordination to four N ends of CN groups and two imidazole molecules while the inner Ni atom preserves its planar coordination. The system of layers remains stacked in an ordered 3D structure through dipole-dipole and {pi}-{pi} interactions between imidazole rings from neighboring layers. In this way, a pillared structure is achieved without requiring the coordination of both nitrogen atoms from imidazole ring. The recorded magnetic data indicate the occurrence of a predominant ferromagnetic interaction at low temperature for Co and Ni but not for Fe. Such magnetic ordering is more favorable for Ni with transition temperature of 14.67 K, which was ascribed to the relatively high polarizing power for this metal. Within the considered T metals, to nickel the highest electron-withdrawing ability corresponds and this leads to an increase for the metal-ligand electron clouds overlapping and to a stronger {pi}-{pi} attractive interaction, two factors that result into a higher magnetic ordering temperature. - Graphical Abstract: Magnetic ordering through the {pi}-{pi} interaction between the imidazole rings. Highlights: Black-Right-Pointing-Pointer Hybrid inorganic-organic solids. Black-Right-Pointing-Pointer Hybrid inorganic-organic molecular

  4. 78 FR 68376 - Removal of Procedures for Delegation of Administration of Grants and Cooperative Agreements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-14

    ... Procedures for Delegation of Administration of Grants and Cooperative Agreements AGENCY: National Aeronautics... regulation agency procedures for the delegation of administration of grants and cooperative agreements. Simultaneous with the removal of the delegation of administration procedures from the regulation, NASA will...

  5. Relations between morning sector Pi 1 pulsation activity and particle and field characteristics observed by the DE 2 satellite

    NASA Technical Reports Server (NTRS)

    Engebretson, M. J.; Cahill, L. J., Jr.; Winningham, J. D.; Rosenberg, T. J.; Arnoldy, R. L.; Maynard, N. C.; Sugiura, M.

    1986-01-01

    Ground-based magnetometer, photometer, and riometer data are combined with low-altitude particle and electric and magnetic field data from the DE-2 spacecraft to provide a more complete characterization of the magnetospheric and tropospheric environment in which morning sector asymmetric Pi 1 pulsations are observed. The results of the study are in agreement with recent conclusions that morning sector asymmetric Pi 1 pulsations are physically related to pulsating aurorae. Precipitation of energetic electrons (E greater than 35 keV) coincides in every instance with the occurrence of these pulsations.

  6. 78 FR 43200 - Proposed Settlement Agreement, Clean Air Act Citizen Suit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-19

    ... Social Responsibility--Los Angeles v. EPA, No. 12-56175, upon receipt of written notice from EPA that the... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OGC-2013-0484; FRL-9835-6] Proposed Settlement Agreement, Clean Air Act Citizen Suit AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of proposed...

  7. Analysis of Hydra PIWI proteins and piRNAs uncover early evolutionary origins of the piRNA pathway.

    PubMed

    Lim, Robyn S M; Anand, Amit; Nishimiya-Fujisawa, Chiemi; Kobayashi, Satoru; Kai, Toshie

    2014-02-01

    To preserve genome integrity, an evolutionarily conserved small RNA-based silencing mechanism involving PIWI proteins and PIWI-interacting RNAs (piRNAs) represses potentially deleterious transposons in animals. Although there has been extensive research into PIWI proteins in bilaterians, these proteins remain to be examined in ancient phyla. Here, we investigated the PIWI proteins Hywi and Hyli in the cnidarian Hydra, and found that both PIWI proteins are enriched in multipotent stem cells, germline stem cells, and in the female germline. Hywi and Hyli localize to the nuage, a perinuclear organelle that has been implicated in piRNA-mediated transposon silencing, together with other conserved nuage and piRNA pathway components. Our findings provide the first report of nuage protein localization patterns in a non-bilaterian. Hydra PIWI proteins possess symmetrical dimethylarginines: modified residues that are known to aid in PIWI protein localization to the nuage and proper piRNA loading. piRNA profiling suggests that transposons are the major targets of the piRNA pathway in Hydra. Our data suggest that piRNA biogenesis through the ping-pong amplification cycle occurs in Hydra and that Hywi and Hyli are likely to preferentially bind primary and secondary piRNAs, respectively. Presumptive piRNA clusters are unidirectionally transcribed and primarily give rise to piRNAs that are antisense to transposons. These results indicate that various conserved features of PIWI proteins, the piRNA pathway, and their associations with the nuage were likely established before the evolution of bilaterians. Copyright © 2013 Elsevier Inc. All rights reserved.

  8. 75 FR 68808 - Agency Information Collection Activities: Free Trade Agreements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-09

    ... information collection: Chile, Singapore, Australia, Morocco, Bahrain, Jordan, Oman, and Peru. These... hours based on the addition of free trade agreements with Oman and Peru. Type of Review: Extension (with...

  9. CNES and NASA Agreements Signed

    NASA Image and Video Library

    2009-09-16

    French Space Agency President Yannick d’Escatha, left, and NASA Administrator Charles Bolden joke with each other as they sign four agreements in support of U.S. and French space cooperation during a ceremony at NASA headquarters in Washington, Thursday, Sept. 17, 2009. Photo Credit: (NASA/Bill Ingalls)

  10. 2 CFR 180.30 - Where does a Federal agency implement these guidelines?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Where does a Federal agency implement these guidelines? 180.30 Section 180.30 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved OMB GUIDELINES TO AGENCIES ON GOVERNMENTWIDE DEBARMENT AND...

  11. Development of highly sensitive cell-based AKT kinase ELISA for monitoring PI3K beta activity and compound efficacy.

    PubMed

    Yanamandra, Mahesh; Kole, Labanyamoy; Giri, Archana; Mitra, Sayan

    2017-01-01

    Phosphatidylinositol-3 kinase (PI3K) pathway regulates multiple cellular functions involving cell survival, growth, motility proliferation, apoptosis, and adhesion. These are deregulated in various diseases such as cancer, atherosclerosis, and inflammation. PI3Ks phosphorylate phosphatidylinositol 4,5-biphosphate (PIP2) yielding phosphatidylinositol 3, 4, 5 triphosphate (PIP3) which in turn activate AKT kinase (serine/threonine kinase), the central enzyme in regulation of metabolic functions. Due to their implications in disease pathophysiology, PI3K/AKT inhibitors became attractive targets for pharmaceutical industries. In order to assess the functional response generated by PI3K inhibitors, an appropriate cell-based screening system is essential in any screening cascade. Here we report the development of highly sensitive in-vitro cell-based kinase ELISA which quantifies the phosphorylated AKT kinase (serine 473) and total AKT kinase directly within the cells upon compound treatment. PI3Kβ overexpressing NIH3T3 cells stimulated by lysophosphatidic acid was used for PI3K/Akt pathway activation. Assay performance reliability and robustness were determined by percentage coefficient of variation (%CV) and Z factor which demonstrated an excellent agreement with assay guidelines. This 96-well plate medium throughput assay methodology was used to screen novel molecules and proved a commendable tool to study the mechanism of action property and target engagement of novel PI3K inhibitors in drug discovery.

  12. A new measurement of the rare decay eta -> pi^0 gamma gamma with the Crystal Ball/TAPS detectors at the Mainz Microtron

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nefkens, B M; Prakhov, S; Aguar-Bartolom��, P

    2014-08-01

    A new measurement of the rare, doubly radiative decay eta->pi^0 gamma gamma was conducted with the Crystal Ball and TAPS multiphoton spectrometers together with the photon tagging facility at the Mainz Microtron MAMI. New data on the dependence of the partial decay width, Gamma(eta->pi^0 gamma gamma), on the two-photon invariant mass squared, m^2(gamma gamma), as well as a new, more precise value for the decay width, Gamma(eta->pi^0 gamma gamma) = (0.33+/-0.03_tot) eV, are based on analysis of 1.2 x 10^3 eta->pi^0 gamma gamma decays from a total of 6 x 10^7 eta mesons produced in the gamma p -> etamore » p reaction. The present results for dGamma(eta->pi^0 gamma gamma)/dm^2(gamma gamma) are in good agreement with previous measurements and recent theoretical calculations for this dependence.« less

  13. Interface through Cooperative Agreements: Eleven Examples of How It Can Work.

    ERIC Educational Resources Information Center

    Jellison, Holly M., Ed.

    Designed as a resource for community colleges wishing to initiate a cooperative agreement with a local agency to offer community education programs, this publication offers 11 representative examples of such agreements. After explaining that the Center for Community Education collected the agreements as part of a 1981 study of community education…

  14. 2 CFR 1.305 - Federal agency responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Federal agency responsibilities. 1.305 Section 1.305 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Responsibilities of OMB and Federal...

  15. 2 CFR 1.305 - Federal agency responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Federal agency responsibilities. 1.305 Section 1.305 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Responsibilities of OMB and Federal...

  16. 2 CFR 1.305 - Federal agency responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Federal agency responsibilities. 1.305 Section 1.305 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Responsibilities of OMB and Federal...

  17. 2 CFR 1.305 - Federal agency responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Federal agency responsibilities. 1.305 Section 1.305 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Responsibilities of OMB and Federal...

  18. 7 CFR 4274.338 - Loan agreements between the Agency and the intermediary.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... necessary to cover a 30-day period in implementing its approved work plan. Advances must be requested by the... by the intermediary. (ii) Ordinarily, life insurance, which may be decreasing term insurance, is... Agency following default by the intermediary, to the Agency. A schedule of life insurance available for...

  19. Amplitude Analysis of the Decay $$D_s^+ \\to \\pi^+ \\pi^- \\pi^+$$ in the Experiment E831/FOCUS (in Portuguese)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schilithz, Anderson Correa; /Rio de Janeiro, CBPF

    We present in this thesis the Dalitz Plot analysis of the D{sub s}{sup +} {yields} {pi}{sup +}{pi}{sup -}{pi}{sup +} decay, with the data of the E831/FOCUS, that took data in 1996 and 1997. The masses and widhts of f{sub 0}(980) and f{sub 0}(1370) are free parametres of the fit on Dalitz Plot, objectiving to study in detail these resonances. After this analysis we present the Spectator Model study on the S wave in this decay. For this study we used the formalism developed by M. Svec [2] for scattering. We present the comparison between the Isobar Model, frequently used inmore » Dalitz Plot analysis, and this formalism.« less

  20. 75 FR 17438 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-06

    ... NUCLEAR REGULATORY COMMISSION [Docket No. NRC-2010-0141] Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: U.S. Nuclear Regulatory Commission (NRC). ACTION: Notice of... new Agreement State applications. Annually for participation by Agreement States in the IMPEP reviews...

  1. 78 FR 19028 - Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    ... POSTAL REGULATORY COMMISSION [Docket No. CP2013-54; Order No. 1681] Negotiated Service Agreement AGENCY: Postal Regulatory Commission. ACTION: Notice SUMMARY: The Commission is noticing a recent Postal Service filing concerning a promotional program involving a temporary change in rates of general...

  2. 76 FR 24026 - Federal Acquisition Regulation; Information Collection; Trade Agreements Certificate

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-29

    ...; Information Collection; Trade Agreements Certificate AGENCY: Department of Defense (DOD), General Services... approved information collection requirement concerning trade agreements certificate. Public comments are... of appropriate technological collection techniques or other forms of information technology. DATES...

  3. 7 CFR 4285.2 - Cooperative agreement purposes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... agency to: (a) Conduct marketing research related to agricultural cooperatives. (b) Assist other organizations in conducting marketing research related to agricultural cooperatives. ... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE AGREEMENTS Federal-State Research on...

  4. Functional Interactions between Major Rice Blast Resistance Genes, Pi-ta and Pi-b, and Minor Blast Resistance QTL.

    PubMed

    Chen, Xinglong; Jia, Yulin; Jia, Melissa H; Pinson, Shannon; Wang, Xueyan; Wu, Bo Ming

    2018-04-16

    Major blast resistance (R) genes confer resistance in a gene-for-gene manner. However, little information is available on interactions between R genes. In this study, interactions between two rice blast R genes, Pi-ta and Pi-b, and other minor blast resistance quantitative trait loci (QTL) were investigated in a recombinant inbred line (RIL) population comprising of 243 RILs from a 'Cybonnet' (CYBT)×'Saber' (SB) cross. CYBT has the R gene Pi-ta and SB has Pi-b. Ten differential isolates of four Magnaporthe oryzae races (IB-1, IB-17, IB-49, and IE-1K) were used to evaluate disease reactions of the 243 RILs under greenhouse conditions. Five resistance QTL were mapped on chromosomes 2, 3, 8, 9, and 12 with a linkage map of 179 single nucleotide polymorphism (SNP) markers. Among them, qBR12 (Q1), was mapped at the Pi-ta locus and accounted for 45.41% of phenotypic variation while qBR2 (Q2) was located at the Pi-b locus and accounted for24.81%of disease reactions. An additive-by-additive epistatic interaction between Q1 (Pi-ta) and Q2 (Pi-b) was detected; they can enhance the disease resistance by an additive 0.93 using the 0 to 9 standard phenotyping method. These results suggest that Pi-ta interacts synergistically with Pi-b.

  5. EPA/USDA Water Quality Trading Partnership Agreement

    EPA Pesticide Factsheets

    The document details an agreement between the U. S. Department of Agriculture, Natural Resources Conservation Service (NRCS) and the U. S. Environmental Protection Agency on collaboration efforts to establish viable water quality credit trading markets.

  6. 2 CFR 1.210 - Applicability to Federal agencies and others.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Applicability to Federal agencies and others. 1.210 Section 1.210 Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND... may apply to— (1) The agency's awarding or administering officials; (2) Non-Federal entities that...

  7. Fully quantum-state resolved study of NO{sub 2} photodissociation. Correlated NO({sup 2}{Pi}{sub {Omega}}, {nu} = 0 J,A) + O({sup 3}P{sub j}) distributions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sanov, A.; Bieler, C.R.; Reisler, H.

    1995-09-14

    Relative O({sup 3}P{sub j} = 2.1.0) spin-orbit populations correlated with specific NO[{sup 2}{Pi}{sub {Omega}} = {1/2}, 3/2; {nu} = 0; f; {Lambda} = {Pi}(A{prime}), {Pi}(A{double_prime})] product states were obtained following photolysis of NO{sub 2} at excess energies E{sup {+-}} = 390, 425, and 1054 cm{sup -1}. These fully quantum state-resolved measurements were carried out by recording spatial profiles of recoiling NO({sup 2}{Pi}{sub {Omega}}, J, {Lambda}) products using polarized radiation for photolysis and state-selective laser ionization detection. The relative O({sup 3}P{sub j}) populations correlated with each NO({sup 2}{Pi}{sub {Omega}}, J, {Lambda}) state show marked fluctuations at each excess energy as amore » function of rotational state and {Lambda}-doublet component. The relative populations also fluctuate as a function of excess energy. The O({sup 3}P{sub j}) spin-orbit population ratios, when averaged over all measurements, exhibit distributions that are colder than statistical, in agreement with previous results. In particular, we find that, on average, O({sup 3}P{sub 1}):O({sup 3}P{sub 2}) population ratios correlated with the ground NO({sup 2}{Pi}{sub {1/2}}) state are colder than the corresponding ratios correlated with the excited NO({sup 2}{Pi}{sub 3/2}) spin-orbit state. These results are in agreement with the state-specific calculations of Katigiri and Kato. 45 refs., 12 figs., 3 tabs.« less

  8. 78 FR 20360 - Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ... POSTAL REGULATORY COMMISSION [Docket No. CP2011-33; Order No. 1685] Negotiated Service Agreement AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a recent Postal Service filing concerning an amendment to Priority Mail Contract 46. This notice informs the public of the...

  9. 78 FR 33864 - Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ... POSTAL REGULATORY COMMISSION [Docket No. CP2011-49; Order No. 1734] Negotiated Service Agreement AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a recent Postal Service filing concerning an amendment to Priority Mail Contract 33. This notice informs the public of the...

  10. 78 FR 33865 - Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ... POSTAL REGULATORY COMMISSION [Docket No. CP2011-50; Order No. 1735] Negotiated Service Agreement AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a recent Postal Service filing concerning an amendment to Express Mail Contract 11. This notice informs the public of the...

  11. 78 FR 54689 - Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ... POSTAL REGULATORY COMMISSION [Docket No. CP2012-41; Order No. 1821] Negotiated Service Agreement AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a recent Postal Service filing concerning an amendment to Parcel Select Contract 4. This notice informs the public of the...

  12. 78 FR 54688 - Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ... POSTAL REGULATORY COMMISSION [Docket No. CP2012-40; Order No. 1820] Negotiated Service Agreement AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a recent Postal Service filing concerning an amendment to Parcel Select Contract 3. This notice informs the public of the...

  13. 78 FR 54689 - Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ... POSTAL REGULATORY COMMISSION [Docket No. CP2012-45; Order No. 1819] Negotiated Service Agreement AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a recent Postal Service filing concerning an amendment to Priority Mail Contract 39. This notice informs the public of the...

  14. 2 CFR 180.35 - By when must a Federal agency implement these guidelines?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false By when must a Federal agency implement these guidelines? 180.35 Section 180.35 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved OMB GUIDELINES TO AGENCIES ON GOVERNMENTWIDE DEBARMENT...

  15. 2 CFR 25.215 - Requirements for agency information systems.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Requirements for agency information systems. 25.215 Section 25.215 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved...

  16. 2 CFR 1.220 - Federal agency implementation of this subtitle.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Federal agency implementation of this subtitle. 1.220 Section 1.220 Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction toSubtitle A § 1.220 Federal agency implementation of this subtitle. A Federal...

  17. 24 CFR 883.607 - Default by owner and/or agency.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Agency defaults under Agreement or Contract. The ACC, the Agreement and the Contract will provide that... enter into the Contract. (b) Rights of HUD if Agency defaults under ACC. The ACC will provide that, if...; however, HUD will continue to pay annual contributions in accordance with the terms of the ACC and the...

  18. 24 CFR 883.607 - Default by owner and/or agency.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Agency defaults under Agreement or Contract. The ACC, the Agreement and the Contract will provide that... enter into the Contract. (b) Rights of HUD if Agency defaults under ACC. The ACC will provide that, if...; however, HUD will continue to pay annual contributions in accordance with the terms of the ACC and the...

  19. PI-RADS version 2: Preoperative role in the detection of normal-sized pelvic lymph node metastasis in prostate cancer.

    PubMed

    Park, Sung Yoon; Shin, Su-Jin; Jung, Dae Chul; Cho, Nam Hoon; Choi, Young Deuk; Rha, Koon Ho; Hong, Sung Joon; Oh, Young Taik

    2017-06-01

    To analyze whether Prostate Imaging Reporting and Data System (PI-RADSv2) scores are associated with a risk of normal-sized pelvic lymph node metastasis (PLNM) in prostate cancer (PCa). A consecutive series of 221 patients who underwent magnetic resonance imaging and radical prostatectomy with pelvic lymph node dissection (PLND) for PCa were retrospectively analyzed under the approval of institutional review board in our institution. No patients had enlarged (≥0.8cm in short-axis diameter) lymph nodes. Clinical parameters [prostate-specific antigen (PSA), greatest percentage of biopsy core, and percentage of positive cores], and PI-RADSv2 score from two independent readers were analyzed with multivariate logistic regression and receiver operating-characteristic curve for PLNM. Diagnostic performance of PI-RADSv2 and Briganti nomogram was compared. Weighted kappa was investigated regarding PI-RADSv2 scoring. Normal-sized PLNM was found in 9.5% (21/221) of patients. In multivariate analysis, PI-RADSv2 (reader 1, p=0.009; reader 2, p=0.026) and PSA (reader 1, p=0.008; reader 2, p=0.037) were predictive of normal-sized PLNM. Threshold of PI-RADSv2 was a score of 5, where PI-RADSv2 was associated with high sensitivity (reader 1, 95.2% [20/21]; reader 2, 90.5% [19/21]) and negative predictive value (reader 1, 99.2% [124/125]; reader 2, 98.6% [136/138]). However, diagnostic performance of PI-RADSv2 (AUC=0.786-0.788) was significantly lower than that of Briganti nomogram (AUC=0.890) for normal-sized PLNM (p<0.05). The inter-reader agreement was excellent for PI-RADSv2 of 5 or not (weighted kappa=0.804). PI-RADSv2 scores may be associated with the risk of normal-sized PLNM in PCa. Copyright © 2017. Published by Elsevier B.V.

  20. 2 CFR 200.205 - Federal awarding agency review of risk posed by applicants.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... cooperative agreements, the Federal awarding agency must have in place a framework for evaluating the risks... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Federal awarding agency review of risk posed by applicants. 200.205 Section 200.205 Grants and Agreements Office of Management and Budget Guidance...

  1. 2 CFR 25.215 - Requirements for agency information systems.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Requirements for agency information systems. 25.215 Section 25.215 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS PRE-AWARD...

  2. 2 CFR 25.215 - Requirements for agency information systems.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Requirements for agency information systems. 25.215 Section 25.215 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS PRE-AWARD...

  3. 2 CFR 25.215 - Requirements for agency information systems.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Requirements for agency information systems. 25.215 Section 25.215 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Pre-award...

  4. 42 CFR 488.11 - State survey agency functions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false State survey agency functions. 488.11 Section 488... (CONTINUED) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES General Provisions § 488.11 State survey agency functions. State and local agencies that have agreements under section 1864...

  5. 42 CFR 488.11 - State survey agency functions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false State survey agency functions. 488.11 Section 488... (CONTINUED) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES General Provisions § 488.11 State survey agency functions. State and local agencies that have agreements under section 1864...

  6. 42 CFR 488.11 - State survey agency functions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false State survey agency functions. 488.11 Section 488... (CONTINUED) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES General Provisions § 488.11 State survey agency functions. State and local agencies that have agreements under section 1864...

  7. 42 CFR 488.11 - State survey agency functions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false State survey agency functions. 488.11 Section 488... (CONTINUED) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES General Provisions § 488.11 State survey agency functions. State and local agencies that have agreements under section 1864...

  8. U.S. and Canada Sign Space Agreement

    NASA Image and Video Library

    2009-10-20

    NASA Administrator Charles Bolden, right, and Canadian Space Agency President Steve MacLean sign a framework agreement on civil space cooperation, Wednesday, Sept. 9, 2009, at the Canadian Embassy in Washington, DC. Photo Credit: (NASA/Bill Ingalls) 

  9. U.S. and Canada Sign Space Agreement

    NASA Image and Video Library

    2009-10-20

    Canadian Space Agency President Steve MacLean signs a framework agreement on civil space cooperation between the U.S. and Canada, Wednesday, Sept. 9, 2009, at the Canadian Embassy in Washington, DC. Photo Credit: (NASA/Bill Ingalls) 

  10. Simulation of the westward traveling surge and Pi 2 pulsations during substorms

    NASA Technical Reports Server (NTRS)

    Kan, J. R.; Sun, W.

    1985-01-01

    The westward traveling surge and the Pi2 pulsations are simulated as a consequence of an enhanced magnetospheric convection in a model of magnetosphere coupling. The coupling is characterized by the bouncing of Alfven waves launched by the enhanced convection. The reflection of Alfven waves from the ionosphere is treated in which the height-integrated conductivity is allowed to be highly nonuniform and fully anisotropic. The reflection of Alfven waves from the magnetosphere is characterized by the coefficient Rm, depending on whether the field lines are open or closed. The conductivity in the model is self-consistently enhanced with increasing upward field-aligned current density. The results of the simulation, including the convection pattern, the electrojets, the field-aligned current, the conductivity enhancement, the oscillation of the westward electrojet, and the average speed of the westward surge are in reasonable agreement with the features of the westward traveling surge and the Pi 2 pulsations observed during substorms.

  11. Faddeev calculations of. pi. D scattering

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Thomas, A.W.

    1976-01-01

    The present status of the Faddeev calculations of ..pi..D scattering is summarized, with emphasis on what has been learned about common approximation methods (for ..pi..-nucleus as well as ..pi..D). Some space is devoted to a discussion of the theoretical work which remains, including a suggestion of co-operation between theorists on a ''homework'' problem. Finally, examples of the interesting phenomena are given which one hopes to investigate through good ..pi..D experiments. Suggestions are made as to which experiments would be most useful.

  12. Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: Redundant roles for PiT-1 and PiT-2

    PubMed Central

    Crouthamel, Matthew H.; Lau, Wei Ling; Leaf, Elizabeth M.; Chavkin, Nick; Wallingford, Mary C.; Peterson, Danielle F.; Li, Xianwu; Liu, Yonggang; Chin, Michael T.; Levi, Moshe; Giachelli, Cecilia M.

    2014-01-01

    Objective Elevated serum phosphate has emerged as a major risk factor for vascular calcification. The sodium-dependent phosphate cotransporter, PiT-1, was previously shown to be required for phosphate-induced osteogenic differentiation and calcification of cultured human VSMCs, but its importance in vascular calcification in vivo, as well as the potential role of its homologue, PiT-2, have not been determined. We investigated the in vivo requirement for PiT-1 in vascular calcification using a mouse model of chronic kidney disease, and the potential compensatory role of PiT-2 using in vitro knockdown and over-expression strategies. Approach and Results Mice with targeted deletion of PiT-1 in VSMCs were generated (PiT-1Δsm). PiT-1 mRNA levels were undetectable whereas PiT-2 mRNA levels were increased 2 fold in the vascular aortic media of PiT-1Δsm compared to PiT-1flox/flox control. When arterial medial calcification was induced in PiT-1Δsm and PiT-1flox/flox by chronic kidney disease followed by dietary phosphate loading, the degree of aortic calcification was not different between genotypes, suggesting compensation by PiT-2. Consistent with this possibility, VSMCs isolated from PiT-1Δsm mice had no PiT-1 mRNA expression, increased PiT-2 mRNA levels, and no difference in sodium-dependent phosphate uptake or phosphate-induced matrix calcification compared to PiT-1flox/flox VSMCs. Knockdown of PiT-2 decreased phosphate uptake and phosphate-induced calcification of PiT-1Δsm VSMCs. Furthermore, over-expression of PiT-2 restored these parameters in human PiT-1-deficient VSMCs. Conclusions PiT-2 can mediate phosphate uptake and calcification of VSMCs in the absence of PiT-1. Mechanistically, PiT-1 and PiT-2 appear to serve redundant roles in phosphate-induced calcification of vascular smooth muscle cells. PMID:23968976

  13. 43 CFR 24.5 - International agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... boundaries. The authority to enter into such agreements is reserved to the President by and with the advice... that give strong consideration to established State programs designed to ensure the conservation of... advice of affected State agencies and to recommend to the U.S. Department of State that representatives...

  14. 43 CFR 24.5 - International agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... boundaries. The authority to enter into such agreements is reserved to the President by and with the advice... that give strong consideration to established State programs designed to ensure the conservation of... advice of affected State agencies and to recommend to the U.S. Department of State that representatives...

  15. U.S. and Canada Sign Space Agreement

    NASA Image and Video Library

    2009-10-20

    NASA Administrator Charles Bolden, right, and Canadian Space Agency President Steve MacLean shake hands after signing a framework agreement on civil space cooperation, Wednesday, Sept. 9, 2009, at the Canadian Embassy in Washington, DC. Photo Credit: (NASA/Bill Ingalls) 

  16. Agencies Need Better Guidance for Choosing among Contracts, Grants, and Cooperative Agreements.

    DTIC Science & Technology

    1981-09-04

    given case may require reference to a range of materials . By en- acting specific authorizing language and providing various sources to help an agency...to: --Inventory recipients’ training materials , get them well-edited, and ready for the agency’s approval, production and distribution. [service... materials to those that do. REA indicated in its Federal Register announcement that under Section 11 of the Rural Electrification Act and under the

  17. 2 CFR 180.20 - What must a Federal agency do to implement these guidelines?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false What must a Federal agency do to implement these guidelines? 180.20 Section 180.20 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved OMB GUIDELINES TO AGENCIES ON GOVERNMENTWIDE DEBARMENT...

  18. 2 CFR 180.635 - May a Federal agency settle a debarment or suspension action?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false May a Federal agency settle a debarment or suspension action? 180.635 Section 180.635 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved OMB GUIDELINES TO AGENCIES ON GOVERNMENTWIDE DEBARMENT...

  19. PiSCP1 and PiCDPK2 Localize to Peroxisomes and Are Involved in Pollen Tube Growth in Petunia Inflata

    PubMed Central

    Guo, Feng; Yoon, Gyeong Mee; McCubbin, Andrew G.

    2013-01-01

    Petunia inflata small CDPK-interacting protein 1 (PiSCP1) was identified as a pollen expressed PiCDPK1 interacting protein using the yeast two hybrid system and the interaction confirmed using pull-down and phosphorylation assays. PiSCP1 is pollen specific and shares amino acid homology with uncharacterized proteins from diverse species of higher plants, but no protein of known function. Expression of PiSCP1-GFP in vivo inhibited pollen tube growth and was shown to localize to peroxisomes in growing pollen tubes. As PiCDPK1 is plasma membrane localized, we investigated the localization of a second isoform, PiCDPK2, and show that it co-localizes to peroxisomes with PiSCP1 and that the two proteins interact in the yeast 2 hybrid interaction assay, suggesting that interaction with the latter CDPK isoform is likely the one of biological relevance. Both PiCDPK2 and PiSCP1 affect pollen tube growth, presumably by mediating peroxisome function, however how they do so is currently not clear. PMID:27137367

  20. 78 FR 50118 - Policy Statement on Adequacy and Compatibility of Agreement State Programs; Statement of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... Agreement State Programs; Statement of Principles and Policy for the Agreement State Program AGENCY: Nuclear... Agreement State Programs'' and the ``Statement of Principles and Policy for the Agreement State Programs... No. ML12202B165. The proposed revisions to the ``Statement of Principles and Policy for the Agreement...

  1. Peripheral zone lesions of intermediary risk in multiparametric prostate MRI: Frequency and validation of the PI-RADSv2 risk stratification algorithm based on focal contrast enhancement.

    PubMed

    Benndorf, Matthias; Waibel, Lorenz; Krönig, Malte; Jilg, Cordula Annette; Langer, Mathias; Krauss, Tobias

    2018-02-01

    To validate the risk stratification algorithm of the Prostate Imaging Reporting and Data System (PI-RADSv2) for intermediary risk lesions (PI-RADSv2 category 3) in the peripheral zone based on focal contrast enhancement and to compare cancer rates in category 3, upgraded category 4 and category 4 based on markedly low ADC value. We retrospectively analyze 172 consecutive patients undergoing prostate MRI with 315 histopathologically verified lesions. We select all lesions either assigned category 3 or category 4 in the peripheral zone for further analysis. We compare cancer rates with the two-sided chi-squared test. To determine inter-observer agreement about contrast enhancement two blinded radiologists evaluate the subset of category 3 lesions based on the diffusion weighted sequence. The frequency of peripheral PI-RADS 3, upgraded PI-RADS 4 and PI-RADS 4 lesions based on markedly low ADC value is 10.8%, 10.8% and 20.3%, respectively. Cancer rates (significant cancer only) in these subgroups are 8.8% (3/34), 23.5% (8/34) and 40.6% (26/64), P < 0.01. Inter-observer agreement is moderate for evaluation of contrast enhancement with kappa values between 0.46 and 0.5. We demonstrate a trend of increasing cancer rate from PI-RADSv2 category 3 to upgraded category 4 to category 4 based on markedly low ADC value. Peripheral lesions of intermediary risk in the diffusion weighted sequence account for 21.6% of all prostate lesions encountered. Since it is likely that patient management recommendations will be linked to assessment categories in future versions of PI-RADS, cancer rates in upgraded category 4 and category 4 based on markedly low ADC values should be in a similar range. We conclude that in future studies of PI-RADSv2 upgraded category 4 and category 4 based on markedly low ADC value should be reported separately to generate a database for meta-analysis of cancer rates. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. 78 FR 35316 - Solicitation for a Cooperative Agreement-Employment Retention Inventory Validation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ... DEPARTMENT OF JUSTICE National Institute of Corrections Solicitation for a Cooperative Agreement... Justice. ACTION: Solicitation for a cooperative agreement. SUMMARY: The National Institute of Corrections... Eligibility of Applicants: An eligible applicant is any public or private agency, educational institution...

  3. Energy Savings Performance Contract Energy Sales Agreement Toolkit

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    FEMP developed the Energy Savings Performance Contracting Energy Sales Agreement (ESPC ESA) Toolkit to provide federal agency contracting officers and other acquisition team members with information that will facilitate the timely execution of ESPC ESA projects.

  4. 44 CFR 206.44 - FEMA-State Agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false FEMA-State Agreements. 206.44 Section 206.44 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE The Declaration Process § 206.44 FEMA...

  5. 44 CFR 206.44 - FEMA-State Agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false FEMA-State Agreements. 206.44 Section 206.44 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE The Declaration Process § 206.44 FEMA...

  6. 44 CFR 206.44 - FEMA-State Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false FEMA-State Agreements. 206.44 Section 206.44 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE The Declaration Process § 206.44 FEMA...

  7. 44 CFR 206.44 - FEMA-State Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true FEMA-State Agreements. 206.44 Section 206.44 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE The Declaration Process § 206.44 FEMA...

  8. 44 CFR 206.44 - FEMA-State Agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false FEMA-State Agreements. 206.44 Section 206.44 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE The Declaration Process § 206.44 FEMA...

  9. 7 CFR 636.9 - Cost-share agreements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF... a minimum duration of one year after the completion of conservation activities identified in the... O&M agreement that describes the O&M for each conservation activity and the agency expectation that...

  10. 7 CFR 636.9 - Cost-share agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF... a minimum duration of one year after the completion of conservation activities identified in the... O&M agreement that describes the O&M for each conservation activity and the agency expectation that...

  11. 7 CFR 636.9 - Cost-share agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF... a minimum duration of one year after the completion of conservation activities identified in the... O&M agreement that describes the O&M for each conservation activity and the agency expectation that...

  12. 7 CFR 636.9 - Cost-share agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF... a minimum duration of one year after the completion of conservation activities identified in the... O&M agreement that describes the O&M for each conservation activity and the agency expectation that...

  13. 75 FR 27768 - Office of International Regimes and Agreements; Proposed Subsequent Arrangement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ... Article 6(iii) of the Agreement for Cooperation Concerning Peaceful Uses of Nuclear Energy (``the... DEPARTMENT OF ENERGY Office of International Regimes and Agreements; Proposed Subsequent Arrangement AGENCY: Department of Energy. ACTION: Subsequent arrangement. SUMMARY: This notice has been issued...

  14. GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion.

    PubMed

    Wang, Hanzhi; Sun, Hui-Qiao; Zhu, Xiaohui; Zhang, Li; Albanesi, Joseph; Levine, Beth; Yin, Helen

    2015-06-02

    The Atg8 autophagy proteins are essential for autophagosome biogenesis and maturation. The γ-aminobutyric acid receptor-associated protein (GABARAP) Atg8 family is much less understood than the LC3 Atg8 family, and the relationship between the GABARAPs' previously identified roles as modulators of transmembrane protein trafficking and autophagy is not known. Here we report that GABARAPs recruit palmitoylated PI4KIIα, a lipid kinase that generates phosphatidylinositol 4-phosphate (PI4P) and binds GABARAPs, from the perinuclear Golgi region to autophagosomes to generate PI4P in situ. Depletion of either GABARAP or PI4KIIα, or overexpression of a dominant-negative kinase-dead PI4KIIα mutant, decreases autophagy flux by blocking autophagsome:lysosome fusion, resulting in the accumulation of abnormally large autophagosomes. The autophagosome defects are rescued by overexpressing PI4KIIα or by restoring intracellular PI4P through "PI4P shuttling." Importantly, PI4KIIα's role in autophagy is distinct from that of PI4KIIIβ and is independent of subsequent phosphatidylinositol 4,5 biphosphate (PIP2) generation. Thus, GABARAPs recruit PI4KIIα to autophagosomes, and PI4P generation on autophagosomes is critically important for fusion with lysosomes. Our results establish that PI4KIIα and PI4P are essential effectors of the GABARAP interactome's fusion machinery.

  15. Multiplex bioimaging of piRNA molecular pathway-regulated theragnostic effects in a single breast cancer cell using a piRNA molecular beacon.

    PubMed

    Lee, Youn Jung; Moon, Sung Ung; Park, Min Geun; Jung, Woon Yong; Park, Yong Keun; Song, Sung Kyu; Ryu, Je Gyu; Lee, Yong Seung; Heo, Hye Jung; Gu, Ha Na; Cho, Su Jeong; Ali, Bahy A; Al-Khedhairy, Abdulaziz A; Lee, Ilkyun; Kim, Soonhag

    2016-09-01

    Recently, PIWI-interacting small non-coding RNAs (piRNAs) have emerged as novel cancer biomarkers candidate because of their high expression level in various cancer types and role in the control of tumor suppressor genes. In this study, a novel breast cancer theragnostics probe based on a single system targeting the piRNA-36026 (piR-36026) molecular pathway was developed using a piR-36026 molecular beacon (MB). The piR-36026 MB successfully visualized endogenous piR-36026 biogenesis, which is highly expressed in MCF7 cells (a human breast cancer cell line), and simultaneously inhibited piR-36026-mediated cancer progression in vitro and in vivo. We discovered two tumor suppressor proteins, SERPINA1 and LRAT, that were directly regulated as endogenous piR-36026 target genes in MCF7 cells. Furthermore, multiplex bioimaging of a single MCF7 cell following treatment with piR-36026 MB clearly visualized the direct molecular interaction of piRNA-36026 with SERPINA1 or LRAT and subsequent molecular therapeutic responses including caspase-3 and PI in the nucleus. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Accounting for the differences in the structures and relative energies of the highly homoatomic np pi-np pi (n > or = 3)-bonded S2I4 2+, the Se-I pi-bonded Se2I4 2+, and their higher-energy isomers by AIM, MO, NBO, and VB methodologies.

    PubMed

    Brownridge, Scott; Crawford, Margaret-Jane; Du, Hongbin; Harcourt, Richard D; Knapp, Carsten; Laitinen, Risto S; Passmore, Jack; Rautiainen, J Mikko; Suontamo, Reijo J; Valkonen, Jussi

    2007-02-05

    The bonding in the highly homoatomic np pi-np pi (n > or = 3)-bonded S2I42+ (three sigma + two pi bonds), the Se-I pi-bonded Se2I42+ (four sigma + one pi bonds), and their higher-energy isomers have been studied using modern DFT and ab initio calculations and theoretical analysis methods: atoms in molecules (AIM), molecular orbital (MO), natural bond orbital (NBO), and valence bond (VB) analyses, giving their relative energies, theoretical bond orders, and atomic charges. The aim of this work was to seek theory-based answers to four main questions: (1) Are the previously proposed simple pi*-pi* bonding models valid for S2I42+ and Se2I42+? (2) What accounts for the difference in the structures of S2I42+ and Se2I42+? (3) Why are the classically bonded isolobal P2I4 and As2I4 structures not adopted? (4) Is the high experimentally observed S-S bond order supported by theoretical bond orders, and how does it relate to high bond orders between other heavier main group elements? The AIM analysis confirmed the high bond orders and established that the weak bonds observed in S2I42+ and Se2I42+ are real and the bonding in these cations is covalent in nature. The full MO analysis confirmed that S2I42+ contains three sigma and two pi bonds, that the positive charge is essentially equally distributed over all atoms, that the bonding between S2 and two I2+ units in S2I42+ is best described by two mutually perpendicular 4c2e pi*-pi* bonds, and that in Se2I42+, two SeI2+ moieties are joined by a 6c2e pi*-pi* bond, both in agreement with previously suggested models. The VB treatment provided a complementary approach to MO analysis and provided insight how the formation of the weak bonds affects the other bonds. The NBO analysis and the calculated AIM charges showed that the minimization of the electrostatic repulsion between EI2+ units (E = S, Se) and the delocalization of the positive charge are the main factors that explain why the nonclassical structures are favored for S2I42

  17. 78 FR 37695 - Federal Acquisition Regulation; Free Trade Agreement (FTA)-Panama

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ... Bahrain, Morocco, Oman, and Peru FTA thresholds for supplies and services ($202,000). The excluded..., Chile FTA, Colombia FTA, NAFTA, Oman FTA, and Peru FTA. II. Discussion and Analysis The Civilian Agency... Understanding or other International Agreement). In addition, the Oman FTA and the Israeli Trade Agreement do...

  18. Observation of psi(3770) --> pi pi J/psi and measurement of Gamma ee[psi(2S)].

    PubMed

    Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Crede, V; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gittelman, B; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Meyer, T O; Onyisi, P U E; Patterson, J R; Peterson, D; Phillips, E A; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Shepherd, M R; Stroiney, S; Sun, W M; Urner, D; Wilksen, T; Weaver, K M; Weinberger, M; Athar, S B; Avery, P; Breva-Newell, L; Patel, R; Potlia, V; Stoeck, H; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Gollin, G D; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; White, E J; Williams, J; Wiss, J; Asner, D M; Edwards, K W; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Gong, D T; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Li, S Z; Poling, R; Scott, A W; Smith, A; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Zweber, P; Ernst, J; Severini, H; Dytman, S A; Love, W; Mehrabyan, S; Mueller, J A; Savinov, V; Li, Z; Lopez, A; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Napolitano, J; He, Q; Muramatsu, H; Park, C S; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Artuso, M; Boulahouache, C; Blusk, S; Butt, J; Dorjkhaidav, O; Li, J; Menaa, N; Mountain, R; Nandakumar, R; Randrianarivony, K; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Briere, R A; Chen, G P; Chen, J; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L

    2006-03-03

    We observe signals for the decays psi(3770) --> XJ/psi from data acquired with the CLEO detector operating at the CESR e+ e- collider with square root of s = 3773 MeV. We measure the following branching fractions Beta(psi(3770) --> XJ/psi and significances: (189 +/- 20 +/- 20) x 10(-5) (11.6sigma) for X = pi+ pi-, (80 +/- 25 +/- 16) x 10(-5) (3.4sigma) for X = pi0 pi0, and (87 +/- 33 +/- 22) x 10(-5) (3.5sigma) for X = eta, where the errors are statistical and systematic, respectively. The radiative return process e+ e- --> gamma psi(2S) populates the same event sample and is used to measure Gamma ee[psi(2S)] = (2.54 +/- 0.03 +/- 0.11) keV.

  19. Cbp80 is needed for the expression of piRNA components and piRNAs

    PubMed Central

    Colombo, Martino; Hernandez, Greco; Beuchle, Dirk; Berger, Fabienne; Peischl, Stephan; Bruggmann, Rémy

    2017-01-01

    Cap binding protein 80 (Cbp80) is the larger subunit of the nuclear cap-binding complex (nCBC), which is known to play important roles in nuclear mRNA processing, export, stability and quality control events. Reducing Cbp80 mRNA levels in the female germline revealed that Cbp80 is also involved in defending the germline against transposable elements. Combining such knockdown experiments with large scale sequencing of small RNAs further showed that Cbp80 is involved in the initial biogenesis of piRNAs as well as in the secondary biogenesis pathway, the ping-pong amplification cycle. We further found that Cbp80 knockdown not only led to the upregulation of transposons, but also to delocalization of Piwi, Aub and Ago3, key factors in the piRNA biosynthesis pathway. Furthermore, compared to controls, levels of Piwi and Aub were also reduced upon knock down of Cbp80. On the other hand, with the same treatment we could not detect significant changes in levels or subcellular distribution (nuage localization) of piRNA precursor transcripts. This shows that Cbp80 plays an important role in the production and localization of the protein components of the piRNA pathway and it seems to be less important for the production and export of the piRNA precursor transcripts. PMID:28746365

  20. Beyond the benzene dimer: an investigation of the additivity of pi-pi interactions.

    PubMed

    Tauer, Tony P; Sherrill, C David

    2005-11-24

    The benzene dimer is the simplest prototype of pi-pi interactions and has been used to understand the fundamental physics of these interactions as they are observed in more complex systems. In biological systems, however, aromatic rings are rarely found in isolated pairs; thus, it is important to understand whether aromatic pairs remain a good model of pi-pi interactions in clusters. In this study, ab initio methods are used to compute the binding energies of several benzene trimers and tetramers, most of them in 1D stacked configurations. The two-body terms change only slightly relative to the dimer, and except for the cyclic trimer, the three- and four-body terms are negligible. This indicates that aromatic clusters do not feature any large nonadditive effects in their binding energies, and polarization effects in benzene clusters do not greatly change the binding that would be anticipated from unperturbed benzene-benzene interactions, at least for the 1D stacked systems considered. Three-body effects are larger for the cyclic trimer, but for all systems considered, the computed binding energies are within 10% of what would be estimated from benzene dimer energies at the same geometries.

  1. 22 CFR 232.13 - Change in agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Change in agreements. 232.13 Section 232.13 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT REPUBLIC OF TUNISIA LOAN GUARANTEES ISSUED UNDER THE DEPARTMENT OF STATE, FOREIGN OPERATIONS, AND RELATED PROGRAMS APPROPRIATIONS ACT, 2012, DIV. I...

  2. 22 CFR 232.13 - Change in agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Change in agreements. 232.13 Section 232.13 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT REPUBLIC OF TUNISIA LOAN GUARANTEES ISSUED UNDER THE DEPARTMENT OF STATE, FOREIGN OPERATIONS, AND RELATED PROGRAMS APPROPRIATIONS ACT, 2012, DIV. I...

  3. 24 CFR 266.505 - Regulatory agreement requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.505 Regulatory agreement requirements. (a) General. (1) The HFA... capital needs. (3) Maintain the project as affordable housing, as defined in § 266.5. (4) Continue to use...

  4. 24 CFR 266.505 - Regulatory agreement requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.505 Regulatory agreement requirements. (a) General. (1) The HFA... capital needs. (3) Maintain the project as affordable housing, as defined in § 266.5. (4) Continue to use...

  5. 24 CFR 266.505 - Regulatory agreement requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.505 Regulatory agreement requirements. (a) General. (1) The HFA... capital needs. (3) Maintain the project as affordable housing, as defined in § 266.5. (4) Continue to use...

  6. 24 CFR 266.505 - Regulatory agreement requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.505 Regulatory agreement requirements. (a) General. (1) The HFA... capital needs. (3) Maintain the project as affordable housing, as defined in § 266.5. (4) Continue to use...

  7. 24 CFR 266.505 - Regulatory agreement requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.505 Regulatory agreement requirements. (a) General. (1) The HFA... capital needs. (3) Maintain the project as affordable housing, as defined in § 266.5. (4) Continue to use...

  8. Dipole moments and transition probabilities of the i 3Pi sub g-b 3Sigma(+) sub u, c 3Pi sub u-a 3Sigma(+) sub g, and i 3Pi sub g-c 3Pi sub u systems of molecular hydrogen

    NASA Technical Reports Server (NTRS)

    Guberman, Steven L.; Dalgarno, A.

    1992-01-01

    Bonn-Oppenheimer-based ab initio calculations of dipole moments from the i 3Pi sub g-b 3Sigma(+) sub u, c 3Pi sub u-a 3Sigma(+) sub g, and i 3Pi sub g-c 3Pi sub u transitions of H2 have been conducted, to yield a tabulation of the dipole transition probabilities and Franck-Condon factors. These factors are given for transitions originating in the lowest vibrational level of the ground X 1Sigma(+) sub g state.

  9. 45 CFR 98.11 - Administration under contracts and agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Agency shall be governed by written agreements that specify the mutual roles and responsibilities of the... subgrantee in any: disallowance under subpart G; complaint or compliance action under subpart J; or hearing...

  10. 4Pi Microscopy.

    PubMed

    Schmidt, Roman; Engelhardt, Johann; Lang, Marion

    2013-01-01

    Optical microscopy has become a key technology in the life sciences today. Its noninvasive nature provides access to the interior of intact and even living cells, where specific molecules can be precisely localized by fluorescent tagging. However, the attainable 3D resolution of an optical microscope has long been hampered by a comparatively poor resolution along the optic axis. By coherent focusing through two objective lenses, 4Pi microscopy improves the axial resolution by three- to fivefold. This primer is intended as a starting point for the design and operation of a 4Pi microscope of type A.

  11. Detection of piRNAs in whitespotted bamboo shark liver.

    PubMed

    Yang, Lingrong; Ge, Yinghua; Cheng, Dandan; Nie, Zuoming; Lv, Zhengbing

    2016-09-15

    Piwi-interacting RNAs (piRNAs) are 26 to 31-nt small non-coding RNAs that have been reported mostly in germ-line cells and cancer cells. However, the presence of piRNAs in the whitespotted bamboo shark liver has not yet been reported. In a previous study of microRNAs in shark liver, some piRNAs were detected from small RNAs sequenced by Solexa technology. A total of 4857 piRNAs were predicted and found in shark liver. We further selected 17 piRNAs with high and significantly differential expression between normal and regenerative liver tissues for subsequent verification by Northern blotting. Ten piRNAs were further identified, and six of these were matched to known piRNAs in piRNABank. The actual expression of six known and four novel piRNAs was validated by qRT-PCR. In addition, a total of 401 target genes of the 10 piRNAs were predicted by miRanda. Through GO and pathway function analyses, only five piRNAs could be annotated with eighteen GO annotations. The results indicated that the identified piRNAs are involved in many important biological responses, including immune inflammation, cell-specific differentiation and development, and angiogenesis. This manuscript provides the first identification of piRNAs in the liver of whitespotted bamboo shark using Solexa technology as well as further elucidation of the regulatory role of piRNAs in whitespotted bamboo shark liver. These findings may provide a useful resource and may facilitate the development of therapeutic strategies against liver damage. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Lauric Acid Stimulates Mammary Gland Development of Pubertal Mice through Activation of GPR84 and PI3K/Akt Signaling Pathway.

    PubMed

    Meng, Yingying; Zhang, Jing; Zhang, Fenglin; Ai, Wei; Zhu, Xiaotong; Shu, Gang; Wang, Lina; Gao, Ping; Xi, Qianyun; Zhang, Yongliang; Liang, Xingwei; Jiang, Qingyan; Wang, Songbo

    2017-01-11

    It has been demonstrated that dietary fat affects pubertal mammary gland development. However, the role of lauric acid (LA) in this process remains unclear. Thus, this study aimed to investigate the effects of LA on mammary gland development in pubertal mice and to explore the underlying mechanism. In vitro, 100 μM LA significantly promoted proliferation of mouse mammary epithelial cell line HC11 by regulating expression of proliferative markers (cyclin D1/3, p21, PCNA). Meanwhile, LA activated the G protein-coupled receptor 84 (GPR84) and PI3K/Akt signaling pathway. In agreement, dietary 1% LA enhanced mammary duct development, increased the expression of GPR84 and cyclin D1, and activated PI3K/Akt in mammary gland of pubertal mice. Furthermore, knockdown of GPR84 or inhibition of PI3K/Akt totally abolished the promotion of HC11 proliferation induced by LA. These results showed that LA stimulated mammary gland development of pubertal mice through activation of GPR84 and PI3K/Akt signaling pathway.

  13. 75 FR 71796 - Proposed Information Collection (Certificate of Affirmation of Enrollment Agreement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-24

    ... (Certificate of Affirmation of Enrollment Agreement--Correspondence Course); Comment Request AGENCY: Veterans... to determine a claimant's date of enrollment in a correspondence course. DATES: Written comments and... Enrollment Agreement-- Correspondence Course VA Form 22-1999c. OMB Control Number: 2900-0576. Type of Review...

  14. 77 FR 25488 - Cooperative Research and Development Agreement: Federally Integrated Communications System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-30

    ... Cooperative Research and Development Agreement (CRADA) with General Dynamics C4 Systems, Inc. to lab... operations of the Coast Guard's Rescue 21 system; (2) General Dynamics' capability to provide the significant... Development Agreement: Federally Integrated Communications System AGENCY: Coast Guard, DHS. ACTION: Notice of...

  15. 40 CFR 305.25 - Informal settlement; voluntary agreement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Informal settlement; voluntary...) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS COMPREHENSIVE ENVIRONMENTAL RESPONSE... Prehearing Procedures § 305.25 Informal settlement; voluntary agreement. (a) Settlement policy. The Agency...

  16. 22 CFR 231.13 - Change in agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Change in agreements. 231.13 Section 231.13 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ARAB REPUBLIC OF EGYPT LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUBLIC LAW 108-11-STANDARD TERMS AND...

  17. 22 CFR 230.13 - Change in agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Change in agreements. 230.13 Section 230.13 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUB. L. 108-11-STANDARD TERMS AND CONDITIONS § 230.13...

  18. 22 CFR 231.13 - Change in agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Change in agreements. 231.13 Section 231.13 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ARAB REPUBLIC OF EGYPT LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUBLIC LAW 108-11-STANDARD TERMS AND...

  19. 22 CFR 231.13 - Change in agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Change in agreements. 231.13 Section 231.13 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ARAB REPUBLIC OF EGYPT LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUBLIC LAW 108-11-STANDARD TERMS AND...

  20. 22 CFR 230.13 - Change in agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Change in agreements. 230.13 Section 230.13 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUB. L. 108-11-STANDARD TERMS AND CONDITIONS § 230.13...

  1. 22 CFR 230.13 - Change in agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Change in agreements. 230.13 Section 230.13 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUB. L. 108-11-STANDARD TERMS AND CONDITIONS § 230.13...

  2. 22 CFR 231.13 - Change in agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Change in agreements. 231.13 Section 231.13 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ARAB REPUBLIC OF EGYPT LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUBLIC LAW 108-11-STANDARD TERMS AND...

  3. 22 CFR 231.13 - Change in agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Change in agreements. 231.13 Section 231.13 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ARAB REPUBLIC OF EGYPT LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUBLIC LAW 108-11-STANDARD TERMS AND...

  4. 22 CFR 233.13 - Change in agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Change in agreements. 233.13 Section 233.13 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT HASHEMITE KINGDOM OF JORDAN LOAN GUARANTEES ISSUED UNDER THE FURTHER CONTINUING APPROPRIATIONS ACT, 2013, DIV. F, PUB. L. 113-6-STANDARD TERMS AND...

  5. 22 CFR 230.13 - Change in agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Change in agreements. 230.13 Section 230.13 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUB. L. 108-11-STANDARD TERMS AND CONDITIONS § 230.13...

  6. 40 CFR 46.190 - Fellowship agreement amendments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... return one copy of each amendment to the award official. If you make the change before you receive the... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Fellowship agreement amendments. 46.190 Section 46.190 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL...

  7. 22 CFR 230.13 - Change in agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Change in agreements. 230.13 Section 230.13 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUB. L. 108-11-STANDARD TERMS AND CONDITIONS § 230.13...

  8. Does the Prostate Imaging-Reporting and Data System (PI-RADS) version 2 improve accuracy in reporting anterior lesions on multiparametric magnetic resonance imaging (mpMRI)?

    PubMed

    Hoffmann, Richard; Logan, Callum; O'Callaghan, Michael; Gormly, Kirsten; Chan, Ken; Foreman, Darren

    2018-01-01

    Multiparametric MRI (mpMRI) is useful in detecting anterior prostate tumours. Due to the location of anterior tumours, they are often diagnosed with a large size and may be suspicious for extra-prostatic extension (EPE). We aim to evaluate whether PI-RADS v2 is more accurate in assessing anterior prostate lesions identified on mpMRI compared to PI-RADS v1. Patients with anterior prostate lesions diagnosed on mpMRI who proceeded to a cognitive fusion transperineal prostate biopsy were identified. Each mpMRI was blinded and read by two experienced prostate MRI radiologists and assigned a PI-RADS v1 and PI-RADS v2 score, and the presence of EPE was estimated. Correlation was made with transperineal histopathology and, where relevant, radical prostatectomy histopathology. Concordance measures between PI-RADS v1 and PI-RADS v2, and between examiners of the same PI-RADS score were calculated using a weighted kappa. Fifty-eight consecutive men were identified. Concordance between the examiners for PI-RADS v1 and for v2 showed substantial agreement (version 1: weighted kappa 0.71; version 2: weighted kappa 0.69). There was no difference in accuracy when using PI-RADS v1 or PI-RADS v2 to predict clinically significant cancer. There was poor correlation between EPE measured on mpMRI compared with EPE in radical prostatectomy histopathology. PI-RADS v2 is reproducible between radiologists but does not have improved accuracy for diagnosing anterior tumours of the prostate when compared to PI-RADS v1. Multiparametric MRI is accurate at detecting anterior tumours with a sensitivity of 86-88%.

  9. Minotaur is critical for primary piRNA biogenesis

    PubMed Central

    Vagin, Vasily V.; Yu, Yang; Jankowska, Anna; Luo, Yicheng; Wasik, Kaja A.; Malone, Colin D.; Harrison, Emily; Rosebrock, Adam; Wakimoto, Barbara T.; Fagegaltier, Delphine; Muerdter, Felix; Hannon, Gregory J.

    2013-01-01

    Piwi proteins and their associated small RNAs are essential for fertility in animals. In part, this is due to their roles in guarding germ cell genomes against the activity of mobile genetic elements. piRNA populations direct Piwi proteins to silence transposon targets and, as such, form a molecular code that discriminates transposons from endogenous genes. Information ultimately carried by piRNAs is encoded within genomic loci, termed piRNA clusters. These give rise to long, single-stranded, primary transcripts that are processed into piRNAs. Despite the biological importance of this pathway, neither the characteristics that define a locus as a source of piRNAs nor the mechanisms that catalyze primary piRNA biogenesis are well understood. We searched an EMS-mutant collection annotated for fertility phenotypes for genes involved in the piRNA pathway. Twenty-seven homozygous sterile strains showed transposon-silencing defects. One of these, which strongly impacted primary piRNA biogenesis, harbored a causal mutation in CG5508, a member of the Drosophila glycerol-3-phosphate O-acetyltransferase (GPAT) family. These enzymes catalyze the first acylation step on the path to the production of phosphatidic acid (PA). Though this pointed strongly to a function for phospholipid signaling in the piRNA pathway, a mutant form of CG5508, which lacks the GPAT active site, still functions in piRNA biogenesis. We have named this new biogenesis factor Minotaur. PMID:23788724

  10. Ion channel regulation by phosphoinositides analyzed with VSPs—PI(4,5)P2 affinity, phosphoinositide selectivity, and PI(4,5)P2 pool accessibility

    PubMed Central

    Rjasanow, Alexandra; Leitner, Michael G.; Thallmair, Veronika; Halaszovich, Christian R.; Oliver, Dominik

    2015-01-01

    The activity of many proteins depends on the phosphoinositide (PI) content of the membrane. E.g., dynamic changes of the concentration of PI(4,5)P2 are cellular signals that regulate ion channels. The susceptibility of a channel to such dynamics depends on its affinity for PI(4,5)P2. Yet, measuring affinities for endogenous PIs has not been possible directly, but has relied largely on the response to soluble analogs, which may not quantitatively reflect binding to native lipids. Voltage-sensitive phosphatases (VSPs) turn over PI(4,5)P2 to PI(4)P when activated by depolarization. In combination with voltage-clamp electrophysiology VSPs are useful tools for rapid and reversible depletion of PI(4,5)P2. Because cellular PI(4,5)P2 is resynthesized rapidly, steady state PI(4,5)P2 changes with the degree of VSP activation and thus depends on membrane potential. Here we show that titration of endogenous PI(4,5)P2 with Ci-VSP allows for the quantification of relative PI(4,5)P2 affinities of ion channels. The sensitivity of inward rectifier and voltage-gated K+ channels to Ci-VSP allowed for comparison of PI(4,5)P2 affinities within and across channel subfamilies and detected changes of affinity in mutant channels. The results also reveal that VSPs are useful only for PI effectors with high binding specificity among PI isoforms, because PI(4,5)P2 depletion occurs at constant overall PI level. Thus, Kir6.2, a channel activated by PI(4,5)P2 and PI(4)P was insensitive to VSP. Surprisingly, despite comparable PI(4,5)P2 affinity as determined by Ci-VSP, the Kv7 and Kir channel families strongly differed in their sensitivity to receptor-mediated depletion of PI(4,5)P2. While Kv7 members were highly sensitive to activation of PLC by Gq-coupled receptors, Kir channels were insensitive even when PI(4,5)P2 affinity was lowered by mutation. We hypothesize that different channels may be associated with distinct pools of PI(4,5)P2 that differ in their accessibility to PLC and VSPs. PMID

  11. 78 FR 33122 - Policy Statement on Adequacy and Compatibility of Agreement State Programs; Statement of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-03

    ... NUCLEAR REGULATORY COMMISSION [NRC-2013-0081] Policy Statement on Adequacy and Compatibility of Agreement State Programs; Statement of Principles and Policy for the Agreement State Program AGENCY: Nuclear.... Nuclear Regulatory Commission (NRC) is proposing revisions to its policy statements on Agreement State...

  12. 77 FR 64519 - Magnesium Elektron; Analysis of Agreement Containing Consent Orders To Aid Public Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... FEDERAL TRADE COMMISSION [File No. 091 0094] Magnesium Elektron; Analysis of Agreement Containing Consent Orders To Aid Public Comment AGENCY: Federal Trade Commission. ACTION: Proposed Consent Agreement. SUMMARY: The consent agreement in this matter settles alleged violations of federal law prohibiting unfair...

  13. Dynamics of Disordered PI-PtBS Diblock Copolymer

    NASA Astrophysics Data System (ADS)

    Watanabe, Hiroshi

    2009-03-01

    Viscoelastic (G^*) and dielectric (ɛ'') data were examined for a LCST-type diblock copolymer composed of polyisoprene (PI; M = 53K) and poly(p-tert- butyl styrene) (PtBS; M = 42K) blocks disordered at T <=120 C^o. Only PI had the type-A dipole parallel along the chain backbone. Thus, the ɛ'' data reflected the global motion of the PI block, while the G^* data detected the motion of the copolymer chain as a whole. Comparison of these data indicated that the PI block relaxed much faster than the PtBS block at low T and the dynamic heterogeneity due to PtBS was effectively quenched to give a frictional nonuniformity for the PI block relaxation. The ɛ'' data were thermo-rheologically complex at low T, partly due to this nonuniformity. However, the block connectivity could have also led to the complexity. For testing this effect, the ɛ'' data were reduced at the iso- frictional state defined with respect to bulk PI. In this state, the ɛ'' data of the copolymer at low and high T, respectively, were close to the data for the star-branched and linear bulk PI. Thus, the PI block appeared to be effectively tethered in space at low T thereby behaving similarly to the star arm while the PI block tended to move cooperatively with the PtBS block at high T to behave similarly to the linear PI, which led to the complexity of the ɛ'' data. The PtBS block also exhibited the complexity (noted from the G^* data), which was well correlated with the complexity of the PI block.

  14. 31 CFR 215.10 - Agency withholding procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., STATE, CITY AND COUNTY INCOME OR EMPLOYMENT TAXES BY FEDERAL AGENCIES Withholding Agreement § 215.10... compensation, each agency shall use the method prescribed by the State income tax statute or city or county... income tax, or (2) By the city or county ordinance from the compensation of each employee subject to such...

  15. 31 CFR 215.10 - Agency withholding procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., STATE, CITY AND COUNTY INCOME OR EMPLOYMENT TAXES BY FEDERAL AGENCIES Withholding Agreement § 215.10... compensation, each agency shall use the method prescribed by the State income tax statute or city or county... income tax, or (2) By the city or county ordinance from the compensation of each employee subject to such...

  16. 48 CFR 5.504 - Use of advertising agencies.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Use of advertising... ACQUISITION PLANNING PUBLICIZING CONTRACT ACTIONS Paid Advertisements 5.504 Use of advertising agencies. (a) General. Basic ordering agreements may be placed with advertising agencies for assistance in producing and...

  17. 48 CFR 5.504 - Use of advertising agencies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Use of advertising... ACQUISITION PLANNING PUBLICIZING CONTRACT ACTIONS Paid Advertisements 5.504 Use of advertising agencies. (a) General. Basic ordering agreements may be placed with advertising agencies for assistance in producing and...

  18. 48 CFR 5.504 - Use of advertising agencies.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Use of advertising... ACQUISITION PLANNING PUBLICIZING CONTRACT ACTIONS Paid Advertisements 5.504 Use of advertising agencies. (a) General. Basic ordering agreements may be placed with advertising agencies for assistance in producing and...

  19. 48 CFR 5.504 - Use of advertising agencies.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Use of advertising... ACQUISITION PLANNING PUBLICIZING CONTRACT ACTIONS Paid Advertisements 5.504 Use of advertising agencies. (a) General. Basic ordering agreements may be placed with advertising agencies for assistance in producing and...

  20. 48 CFR 5.504 - Use of advertising agencies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Use of advertising... ACQUISITION PLANNING PUBLICIZING CONTRACT ACTIONS Paid Advertisements 5.504 Use of advertising agencies. (a) General. Basic ordering agreements may be placed with advertising agencies for assistance in producing and...

  1. Assessing the Universal Structure of Personality in Early Adolescence: The NEO-PI-R and NEO-PI-3 in 24 Cultures

    PubMed Central

    De Fruyt, Filip; De Bolle, Marleen; McCrae, Robert R.; Terracciano, Antonio; Costa, Paul T.

    2010-01-01

    The structure and psychometric characteristics of the NEO-PI-3, a more readable version of the NEO-PI-R, are examined and compared with NEO-PI-R characteristics using data from college student observer ratings of 5,109 adolescents aged 12 to 17 from 24 cultures. Replacement items in the PI-3 showed on average stronger item/total correlations and slightly improved facet reliabilities compared with the NEO-PI-R in both English- and non-English-speaking samples. NEO-PI-3 replacement items did not substantially affect scale means compared with the original scales. Analyses across and within cultures confirmed the intended factor structure of both versions when used to describe young adolescents. We discuss implications of these cross-cultural findings for the advancement of studies in adolescence and personality development across the lifespan. PMID:19419953

  2. 78 FR 35319 - Solicitation for a Cooperative Agreement-Curriculum Development: Planning and Implementing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ... DEPARTMENT OF JUSTICE National Institute of Corrections Solicitation for a Cooperative Agreement... Institute of Corrections, U.S. Department of Justice. ACTION: Solicitation for a Cooperative Agreement.... Eligibility of Applicants: An eligible applicant is any public or private agency, educational institution...

  3. 77 FR 61787 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Agreement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-11

    ... for OMB Review; Comment Request; Agreement Approval Process for Use of Functional Affirmative Action..., ``Agreement Approval Process for Use of Functional Affirmative Action Programs,'' to the Office of Management... 11246 permit Federal supply and service contractors to develop affirmative action programs (AAPs) that...

  4. 40 CFR 35.3545 - Capitalization grant agreement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... required to determine compliance with section 1452 of the Act. (c) Operating agreement. At the option of a... Fund in accordance with the requirements and objectives of the Act and this subpart. (e) Roles and..., the State must describe the roles and responsibilities of each agency in the capitalization grant...

  5. 76 FR 41861 - Voluntary Intermodal Sealift Agreement (VISA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ... DEPARTMENT OF TRANSPORTATION Maritime Administration Voluntary Intermodal Sealift Agreement (VISA) AGENCY: Maritime Administration, DOT. ACTION: Notice of open season for enrollment in the VISA program. Introduction The VISA program was established pursuant to section 708 of the Defense Production Act of 1950, as...

  6. 75 FR 52594 - Voluntary Intermodal Sealift Agreement (VISA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... DEPARTMENT OF TRANSPORTATION Maritime Administration Voluntary Intermodal Sealift Agreement (VISA) AGENCY: Maritime Administration, DOT. ACTION: Notice of open season for enrollment in the VISA program. Introduction The VISA program was established pursuant to section 708 of the Defense Production Act of 1950, as...

  7. 77 FR 53963 - Voluntary Intermodal Sealift Agreement (VISA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-04

    ... DEPARTMENT OF TRANSPORTATION Maritime Administration Voluntary Intermodal Sealift Agreement (VISA) AGENCY: Maritime Administration, DOT. ACTION: Notice of open season for enrollment in the VISA program. Introduction The VISA program was established pursuant to section 708 of the Defense Production Act of 1950, as...

  8. The use of polyimide-modified aluminum nitride fillers in AlN@PI/Epoxy composites with enhanced thermal conductivity for electronic encapsulation

    PubMed Central

    Zhou, Yongcun; Yao, Yagang; Chen, Chia-Yun; Moon, Kyoungsik; Wang, Hong; Wong, Ching-ping

    2014-01-01

    Polymer modified fillers in composites has attracted the attention of numerous researchers. These fillers are composed of core-shell structures that exhibit enhanced physical and chemical properties that are associated with shell surface control and encapsulated core materials. In this study, we have described an apt method to prepare polyimide (PI)-modified aluminum nitride (AlN) fillers, AlN@PI. These fillers are used for electronic encapsulation in high performance polymer composites. Compared with that of untreated AlN composite, these AlN@PI/epoxy composites exhibit better thermal and dielectric properties. At 40 wt% of filler loading, the highest thermal conductivity of AlN@PI/epoxy composite reached 2.03 W/mK. In this way, the thermal conductivity is approximately enhanced by 10.6 times than that of the used epoxy matrix. The experimental results exhibiting the thermal conductivity of AlN@PI/epoxy composites were in good agreement with the values calculated from the parallel conduction model. This research work describes an effective pathway that modifies the surface of fillers with polymer coating. Furthermore, this novel technique improves the thermal and dielectric properties of fillers and these can be used extensively for electronic packaging applications. PMID:24759082

  9. Reprint Series: Computation of Pi. RS-7.

    ERIC Educational Resources Information Center

    Schaaf, William L., Ed.

    This is one in a series of SMSG supplementary and enrichment pamphlets for high school students. This series makes available expository articles which appeared in a variety of mathematical periodicals. Topics covered include: (1) the latest about pi; (2) a series useful in the computation of pi; (3) an ENIAC determination of pi and e to more than…

  10. 9 CFR 54.2 - Cooperative agreements and memoranda of understanding with States.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... of understanding with States. 54.2 Section 54.2 Animals and Animal Products ANIMAL AND PLANT HEALTH... DISEASES CONTROL OF SCRAPIE § 54.2 Cooperative agreements and memoranda of understanding with States. APHIS will execute cooperative agreements and/or memoranda of understanding with the animal health agency of...

  11. Mapping of the minimal inorganic phosphate transporting unit of human PiT2 suggests a structure universal to PiT-related proteins from all kingdoms of life

    PubMed Central

    2011-01-01

    Background The inorganic (Pi) phosphate transporter (PiT) family comprises known and putative Na+- or H+-dependent Pi-transporting proteins with representatives from all kingdoms. The mammalian members are placed in the outer cell membranes and suggested to supply cells with Pi to maintain house-keeping functions. Alignment of protein sequences representing PiT family members from all kingdoms reveals the presence of conserved amino acids and that bacterial phosphate permeases and putative phosphate permeases from archaea lack substantial parts of the protein sequence when compared to the mammalian PiT family members. Besides being Na+-dependent Pi (NaPi) transporters, the mammalian PiT paralogs, PiT1 and PiT2, also are receptors for gamma-retroviruses. We have here exploited the dual-function of PiT1 and PiT2 to study the structure-function relationship of PiT proteins. Results We show that the human PiT2 histidine, H502, and the human PiT1 glutamate, E70, - both conserved in eukaryotic PiT family members - are critical for Pi transport function. Noticeably, human PiT2 H502 is located in the C-terminal PiT family signature sequence, and human PiT1 E70 is located in ProDom domains characteristic for all PiT family members. A human PiT2 truncation mutant, which consists of the predicted 10 transmembrane (TM) domain backbone without a large intracellular domain (human PiT2ΔR254-V483), was found to be a fully functional Pi transporter. Further truncation of the human PiT2 protein by additional removal of two predicted TM domains together with the large intracellular domain created a mutant that resembles a bacterial phosphate permease and an archaeal putative phosphate permease. This human PiT2 truncation mutant (human PiT2ΔL183-V483) did also support Pi transport albeit at very low levels. Conclusions The results suggest that the overall structure of the Pi-transporting unit of the PiT family proteins has remained unchanged during evolution. Moreover, in

  12. 49 CFR 20.200 - Agency and legislative liaison.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Agency and legislative liaison. 20.200 Section 20.200 Transportation Office of the Secretary of Transportation NEW RESTRICTIONS ON LOBBYING Activities... cooperative agreement if the payment is for agency and legislative liaison activities not directly related to...

  13. Assessing the universal structure of personality in early adolescence: The NEO-PI-R and NEO-PI-3 in 24 cultures.

    PubMed

    De Fruyt, Filip; De Bolle, Marleen; McCrae, Robert R; Terracciano, Antonio; Costa, Paul T

    2009-09-01

    The structure and psychometric characteristics of the NEO Personality Inventory-3 (NEO-PI-3), a more readable version of the Revised NEO Personality Inventory (NEO-PI-R), are examined and compared with NEO-PI-R characteristics using data from college student observer ratings of 5,109 adolescents aged 12 to 17 years from 24 cultures. Replacement items in the PI-3 showed on average stronger item-total correlations and slightly improved facet reliabilities compared with the NEO-PI-R in both English- and non-English-speaking samples. NEO-PI-3 replacement items did not substantially affect scale means compared with the original scales. Analyses across and within cultures confirmed the intended factor structure of both versions when used to describe young adolescents. The authors discuss implications of these cross-cultural findings for the advancement of studies in adolescence and personality development across the lifespan.

  14. 76 FR 70461 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... Capezzuto, Office of Information Management, Food and Drug Administration, 1350 Piccard Dr., PI50-400B... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2011-N-0015] Agency Information Collection Activities; Announcement of Office of Management and Budget Approval...

  15. 75 FR 24707 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    ... Gittleson, Office of Information Management, Food and Drug Administration, 1350 Piccard Dr., PI50-400B... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2009-N-0486] Agency Information Collection Activities; Announcement of Office of Management and Budget Approval...

  16. 77 FR 21565 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-10

    ...] Agency Information Collection Activities; Announcement of Office of Management and Budget Approval; Food... ``Food and Drug Administration Recall Regulations'' has been approved by the Office of Management and..., Office of Information Management, Food and Drug Administration, 1350 Piccard Dr., PI50-400B, Rockville...

  17. 75 FR 76011 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ...., Office of Information Management, Food and Drug Administration, 1350 Piccard Dr., PI50-400B, Rockville... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2010-N-0083] Agency Information Collection Activities; Announcement of Office of Management and Budget Approval...

  18. 34 CFR 682.404 - Federal reinsurance agreement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... reinsurance agreement, the Secretary reimburses the guaranty agency for— (i) 95 percent of its losses on..., 1998; (ii) 98 percent of its losses on default claim payments to lenders for loans for which the first... losses on default claim payments to lenders— (A) For loans for which the first disbursement is made prior...

  19. 22 CFR 205.1 - Grants and cooperative agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., including the definition, practice, and expression of its religious beliefs, provided that it does not use... beneficiary on the basis of religion or religious belief. (f) No grant document, contract, agreement, covenant... Section 205.1 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PARTICIPATION BY RELIGIOUS...

  20. 22 CFR 205.1 - Grants and cooperative agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., including the definition, practice, and expression of its religious beliefs, provided that it does not use... beneficiary on the basis of religion or religious belief. (f) No grant document, contract, agreement, covenant... Section 205.1 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PARTICIPATION BY RELIGIOUS...