Sample records for aguda por hierro

  1. Trombocitopenia induzida por heparina em paciente com oclusão arterial aguda

    PubMed Central

    Pimenta, Rafael Elias Farres; Yoshida, Winston Bonetti; Rollo, Hamilton Almeida; Sobreira, Marcone Lima; Bertanha, Matheus; Mariúba, Jamil Victor de Oliveira; Jaldin, Rodrigo Gibin; de Camargo, Paula Angeleli Bueno

    2016-01-01

    Resumo A trombocitopenia induzida por heparina é uma complicação grave da terapêutica anticoagulante com heparina e está associada à formação de anticorpos antifator IV plaquetário. Costuma surgir a partir do quinto dia do tratamento, com queda de pelo menos 50% da contagem plaquetária. Em decorrência da ativação plaquetária concomitante, pode ocorrer quadro de trombose, venosa ou arterial, com repercussões clínicas graves. Apresentamos um caso de paciente portador de síndrome do anticorpo antifosfolípide, com quadro de oclusão arterial aguda, que foi tratado cirurgicamente e recebeu heparina não fracionada no intra e pós-operatório. No quinto dia de tratamento anticoagulante, apresentou queda maior de 50% da contagem de plaquetas em relação à contagem pré-heparina. A suspeita de trombocitopenia induzida por heparina e seus aspectos diagnósticos e terapêuticos serão abordados neste desafio terapêutico.

  2. Spatial vent opening probability map of El Hierro Island (Canary Islands, Spain)

    NASA Astrophysics Data System (ADS)

    Becerril, Laura; Cappello, Annalisa; Galindo, Inés; Neri, Marco; Del Negro, Ciro

    2013-04-01

    The assessment of the probable spatial distribution of new eruptions is useful to manage and reduce the volcanic risk. It can be achieved in different ways, but it becomes especially hard when dealing with volcanic areas less studied, poorly monitored and characterized by a low frequent activity, as El Hierro. Even though it is the youngest of the Canary Islands, before the 2011 eruption in the "Las Calmas Sea", El Hierro had been the least studied volcanic Island of the Canaries, with more historically devoted attention to La Palma, Tenerife and Lanzarote. We propose a probabilistic method to build the susceptibility map of El Hierro, i.e. the spatial distribution of vent opening for future eruptions, based on the mathematical analysis of the volcano-structural data collected mostly on the Island and, secondly, on the submerged part of the volcano, up to a distance of ~10-20 km from the coast. The volcano-structural data were collected through new fieldwork measurements, bathymetric information, and analysis of geological maps, orthophotos and aerial photographs. They have been divided in different datasets and converted into separate and weighted probability density functions, which were then included in a non-homogeneous Poisson process to produce the volcanic susceptibility map. Future eruptive events on El Hierro is mainly concentrated on the rifts zones, extending also beyond the shoreline. The major probabilities to host new eruptions are located on the distal parts of the South and West rifts, with the highest probability reached in the south-western area of the West rift. High probabilities are also observed in the Northeast and South rifts, and the submarine parts of the rifts. This map represents the first effort to deal with the volcanic hazard at El Hierro and can be a support tool for decision makers in land planning, emergency plans and civil defence actions.

  3. Full-Vector Geomagnetic Field Records for the Late Quaternary from El Hierro and the Eifel

    NASA Astrophysics Data System (ADS)

    Monster, M.; de Groot, L. V.; Dekkers, M. J.; van Galen, J. P.; Kuiper, K.; Langemeijer, J.; Wiarda, L. R.

    2015-12-01

    Twenty-eight flows in the age range of c. 100 to c. 500 ka were sampled on the island of El Hierro (Canary Islands, Spain) and twelve in the Eifel (Germany). All sites from the Eifel had been previously dated, whereas the ages of the El Hierro flows were approximated by stratigraphic and directional coherency with a dated section c. 4 km to the north-east. Additionally, seven flows were dated using the ThermoFisher Helix multi-collector mass spectrometer at VU University Amsterdam (the Netherlands). The rocks were subjected to standard rock magnetic and palaeomagnetic experiments. Palaeodirections were obtained using both thermal and alternating-field demagnetisation techniques. Apart from two sites that appear to have been struck by lightning, all sites yielded reliable palaeodirections. Absolute palaeointensities were obtained using three different methods: IZZI-Thellier, the multispecimen protocol and the calibrated pseudo-Thellier technique. Nineteen sites from El Hierro and all twelve sites from the Eifel passed the selection criteria for one or more of these methods, with the pseudo-Thellier technique having the highest success rate (c. 35% for El Hierro and 55% for the Eifel). The palaeointensities obtained for El Hierro were mostly between 20 and 40 μT and for the Eifel between 20 and 50 μT, both with a tendency to be somewhat low compared to the present-day field of c. 39 μT and c. 49 μT, respectively. The pseudo-Thellier and multispecimen methods generally yielded lower palaeointensities than IZZI-Thellier, but no clear trend was visible.

  4. Soil gas radon and volcanic activity at El Hierro (Canary Islands) before and after the 2011-2012 submarine eruption

    NASA Astrophysics Data System (ADS)

    Barrancos, J.; Padilla, G.; Hernandez Perez, P. A.; Padron, E.; Perez, N.; Melian Rodriguez, G.; Nolasco, D.; Dionis, S.; Rodriguez, F.; Calvo, D.; Hernandez, I.

    2012-12-01

    El Hierro is the youngest and southernmost island of the Canarian archipelago and represents the summit of a volcanic shield elevating from the surrounding seafloor at depth of 4000 m to up to 1501 m above sea level. The island is believed to be near the present hotspot location in the Canaries with the oldest subaerial rocks dated at 1.12 Ma. The subaerial parts of the El Hierro rift zones (NE, NW and S Ridges) are characterized by tightly aligned dyke complexes with clusters of cinder cones as their surface expressions. Since July 16, 2011, an anomalous seismicity at El Hierro Island was recorded by IGN seismic network. Volcanic tremor started at 05:15 hours on October 10, followed on the afternoon of October 12 by a green discolouration of seawater, strong bubbling and degassing indicating the initial stage of submarine volcanic eruption at approximately 2 km off the coast of La Restinga, El Hierro. Soil gas 222Rn and 220Rn activities were continuously measured during the period of the recent volcanic unrest occurred at El Hierro, at two different geochemical stations, HIE02 and HIE03. Significant increases in soil 222Rn activity and 222Rn/220Rn ratio from the soil were observed at both stations prior the submarine eruption off the coast of El Hierro, showing the highest increases before the eruption onset and the occurrence of the strongest seismic event (M=4.6). A statistical analysis showed that the long-term trend of the filtered data corresponded closely to the seismic energy released during the volcanic unrest. The observed increases of 222Rn are related to the rock fracturing processes (seismic activity) and the magmatic CO2 outflow increase, as observed in HIE03 station. Under these results, we find that continuous soil radon studies are important for evaluating the volcanic activity of El Hierro and they demonstrate the potential of applying continuous monitoring of soil radon to improve and optimize the detection of early warning signals of future

  5. Origin and significance of the 2011 El Hierro xeno-pumice

    NASA Astrophysics Data System (ADS)

    Zaczek-Pedroza, Kirsten; Troll, Valentin R.; Deegan, Frances M.; Meade, Fiona C.; Burchardt, Steffi; Carracedo, Juan C.; Klügel, Andreas; Harris, Chris; Wiesmaier, Sebastian; Berg, Sylvia E.; Barker, Abigail K.

    2014-05-01

    During the first week of the 2011/2012 submarine eruption off El Hierro (Canary Islands), peculiar light-coloured pumiceous rocks (xeno-pumice) were found floating on the sea. The appearance of these rocks led to a potentially inappropriate response from the authorities, because the rocks were viewed as likely indicators of high-silica magma and possible explosive eruptive behaviour. However, the eruption remained a relatively minor and dominantly effusive event and the origin and significance of these peculiar xeno-pumice rocks for volcanic monitoring remains unresolved. Three contrasting models have been put forward, describing them as: a) recycled hydrothermally altered felsic magmatic rocks (Meletlidis et al., 2012, Geophys. Res. Lett., 39:L17302), b) sediment-contaminated high-silica magma (Sigmarsson et al., 2013, Contrib. Mineral. Petrol., 165:601-622) or c) frothy xenoliths from pre-island sedimentary strata that were melted while immersed in magma (Troll et al., 2012, Solid Earth, 3:97-110). Here, we combine the three available datasets to assess the origin of El Hierro xeno-pumice in the light of texture, mineralogy, major and trace element composition, and oxygen isotope characteristics in order to discuss their significance. We note that: 1) Sedimentary relicts occur frequently in xeno-pumice samples with occasionally observed relict bedding. 2) Vesicle sizes are extremely variable, which documents multiple degassing events. The vesicles are biggest especially close to sedimentary relicts, likely the result of a complex mix of minerals and porewaters originally present. 3) The mineral assemblage of xeno-pumice includes quartz, smectite, illite, wollastonite, jasper and mica (XRD) and is akin to marine sedimentary rocks in the region (Hoernle, 1998, J. Petrol.,39:859-880; Robertson & Stillman, 1979, J. Geol. Soc., 136:47 -60; Aparicio et al., 2006, Geol. Mag. 143:181 -193). 4) CIPW norms calculated from xeno-pumice major element compositions show the

  6. Psychological aspects in a volcanic crisis: El Hierro Island eruption (October, 2011).

    NASA Astrophysics Data System (ADS)

    Lopez, P.; Llinares, A.; Garcia, A.; Marrero, J. M.; Ortiz, R.

    2012-04-01

    The recent eruption on the El Hierro Island (Canary Islands, Spain) has shown that Psychology plays an important role in the emergence management of a natural phenomenon. However, Psychology continues to have no social coverage it deserves in the mitigation of the effects before, during and after the occurrence of a natural phenomenon. Keep in mind that an unresolved psychological problem involves an individual and collective mismatch may become unrecoverable. The population of El Hierro has been under a state of alert since July 2011, when seismic activity begins, until the occurrence of submarine eruption in October 2011 that is held for more than three months. During this period the inhabitants of the small island have gone through different emotional states ranging from confusion to disappointment. A volcanic eruption occurs not unexpectedly, allowing to have a time of preparation / action before the disaster. From the psychological point of view people from El Hierro Island have responded to different stages of the same natural process. Although the island of El Hierro is of volcanic origin, the population has no historical memory since the last eruption occurred in 1793. Therefore, the educational system does not adequately address the formation in volcanic risk. As a result people feel embarrassment when the seismovolcanic crisis begins, although no earthquakes felt. As an intermediate stage, when the earthquakes are felt by the population, scientists and operational Emergency Plan care to inform and prepare actions in case of a possible eruption. The population feel safe despite the concerns expressed by not knowing where, how and when the eruption will occur. Once started the submarine eruption, taking into account that all the actions (evacuation, relocation, etc.) have worked well and that both their basic needs and security are covered there are new states of mind. These new emotional states ranging from disenchantment with the phenomenology of the

  7. Geochronological constraints on the evolution of El Hierro (Canary Islands)

    NASA Astrophysics Data System (ADS)

    Becerril, Laura; Ubide, Teresa; Sudo, Masafumi; Martí, Joan; Galindo, Inés; Galé, Carlos; Morales, Jose María; Yepes, Jorge; Lago, Marceliano

    2016-01-01

    New age data have been obtained to time constrain the recent Quaternary volcanism of El Hierro (Canary Islands) and to estimate its recurrence rate. We have carried out 40Ar/39Ar geochronology on samples spanning the entire volcanostratigraphic sequence of the island and 14C geochronology on the most recent eruption on the northeast rift of the island: 2280 ± 30 yr BP. We combine the new absolute data with a revision of published ages onshore, some of which were identified through geomorphological criteria (relative data). We present a revised and updated chronology of volcanism for the last 33 ka that we use to estimate the maximum eruptive recurrence of the island. The number of events per year determined is 9.7 × 10-4 for the emerged part of the island, which means that, as a minimum, one eruption has occurred approximately every 1000 years. This highlights the need of more geochronological data to better constrain the eruptive recurrence of El Hierro.

  8. Early signs of geodynamic activity before the 2011-2012 El Hierro eruption

    NASA Astrophysics Data System (ADS)

    López, Carmen; García-Cañada, Laura; Martí, Joan; Domínguez Cerdeña, Itahiza

    2017-04-01

    The potential relation between mantle plume dynamics, regional tectonics and eruptive activity in the Canary Islands has not been studied yet through the analysis of long-time series of geophysical observational data. The existence of highly reliable seismic and GNSS data has enabled us to study from 1996 to 2014 the geodynamic evolution of the North Atlantic Azores-Gibraltar region and its relationship with recent volcanic activity in El Hierro (Canary Islands, Spain). We compiled a new and unified regional seismic catalog and used long time-series of surface displacements recorded by permanent GNSS stations in the region. A regional- and local-scale analysis based on these data enabled us to identify signs of anomalous tectonic activity from 2003 onwards, whose intensity increased in 2007 and finally accelerated three months before the onset of the volcanic eruption on El Hierro in October 2011. This activity includes a regional extension and an uplift process that affects the southern Iberian Peninsula, NW Africa, and the Canary Islands. We interpret these observations as early signs of the geodynamic activity, which led to El Hierro eruption and the subsequent episodes of magma intrusion. Results point to the significant contribution of the mantle plume dynamics (i.e. external forces) in this renewed volcanic activity in the Canary Islands and emphasize the role of mantle dynamics in controlling regional tectonics.

  9. Melt inclusion study of the most recent basanites from El Hierro and Lanzarote, Canary Islands

    NASA Astrophysics Data System (ADS)

    Gomez-Ulla, Alejandra; Sigmarsson, Olgeir; Huertas, Maria Jose; Ancochea, Eumenio

    2015-04-01

    The latest eruptions of both Lanzarote (one of the oldest and easternmost of the Canary Island archipelago) and El Hierro (the youngest and westernmost) produced basanite lavas. Major, volatile and trace element concentrations of melt inclusion (MI) hosted in olivine for both eruptions have been analysed. The basanites display primitive mantle normalized trace element spectra suggesting a magma source largely composed of recycled oceanic crust. In addition, beneath Lanzarote an interaction with a carbonatitic fluid phase or metasome would explain eccentric Ba/U and other trace element ratios. Contribution of carbonatitic component would readily account for extremely volatile-rich (Cl, F, S) MI from Lanzarote (Cl=1577-2500 ppm) whereas the maximum for El Hierro is 1080 ppm. The submarine character of the 2011-12 eruption off El Hierro appears to have affected the degassing behavior, whereas estimated sulfur emission to the atmosphere during the historical Lanzarote eruptions are amongst the highest observed so far. An estimated magma volume (VDRE) of 0.02 km3 yields atmospheric mass loading of 0.2 Mt SO2 from the 1824 Lanzarote eruption. Scaling the volume of the 1824 Lanzarote eruption to that of the previous Timanfaya eruption (1730-6; 5 km3) results in estimated 12 Mt SO2, an atmospheric mass loading only outnumbered by the historical Laki and Eldgjá eruptions in Iceland. The significantly greater volatile budget of basanites from Lanzarote compared to El Hierro is thus controlled by more fertile source composition closer to the African continent.

  10. Enfermedad diarreica aguda por Escherichia coli patógenas en Colombia

    PubMed Central

    Gómez-Duarte, Oscar G.

    2014-01-01

    Resumen Las cepas de E. coli patógenas intestinales son causas importantes de la enfermedad diarreica aguda (EDA) en niños menores de 5 años en América Latina, África y Asia y están asociadas a alta mortalidad en niños en las comunidades más pobres de África y el Sudeste Asiático. Estudios sobre el papel de las E. coli patógenas intestinales en la EDA infantil en Colombia y otros países de América Latina son limitados debido a la carencia de ensayos para detección de estos patógenos en los laboratorios clínicos de centros de salud. Estudios recientes han reportado la detección de E. coli patógenas intestinales en Colombia, siendo la E. coli enterotoxigénica la cepa más frecuentemente asociada a diarrea en niños menores de 5 años. Otros patógenos detectados en estos pacientes incluyen las E. coli enteroagregativa, enteropatógena, productora de toxina Shiga, y de adherencia difusa. Con base en estudios que reportan la presencia de E. coli productora de toxina Shiga y E. coli enteroagregativa en carnes y vegetales en supermercados, se cree que productos alimentarios contaminados contribuyen a la transmisión de estos patógenos y a la infección del huésped susceptible. Más estudios son necesarios para evaluar los mecanismos de transmisión, el impacto en la epidemiologia de la EDA, y las pautas de manejo y prevención de estos patógenos que afectan la población pediátrica en Colombia. PMID:25491457

  11. Early signs of geodynamic activity before the 2011-2012 El Hierro eruption

    NASA Astrophysics Data System (ADS)

    López, Carmen; García-Cañada, Laura; Martí, Joan; Domínguez Cerdeña, Itahiza

    2017-02-01

    The potential relation between mantle plume dynamics, regional tectonics and eruptive activity in the Canary Islands has not been studied yet through the analysis of long-time series of geophysical observational data. The existence of highly reliable seismic and geodetic data has enabled us to study from 1996 to 2014 the geodynamic evolution of the North Atlantic Azores-Gibraltar region (including the NW African margin) and its relationship with recent volcanic activity in El Hierro (Canary Islands). We compiled a new and unified regional seismic catalog and used long time-series of digital 3D surface displacements recorded by permanent GPS stations in the region. A joint regional- and local-scale analysis based on these data enabled us to identify signs of anomalous tectonic activity from 2003 onwards, whose intensity increased in 2007 and finally accelerated three months before the onset of the volcanic eruption on El Hierro in October 2011. Activity included the occurrence of regional extension and an uplift process affecting the southern Iberian Peninsula, NW Africa, and the Canary Islands. We interpret these observations as early signs of the geodynamic activity, which led to El Hierro eruption and the subsequent episodes of magma intrusion. Results point to the significant contribution of the mantle plume dynamics (i.e. external forces) in this renewed volcanic activity in the Canary Islands and emphasize the role of mantle dynamics in controlling regional tectonics.

  12. From 3D to 4D seismic tomography at El Hierro Island (Canary Islands, Spain)

    NASA Astrophysics Data System (ADS)

    Garcia-Yeguas, A.; Koulakov, I.; Jakovlev, A.; Ibáñez, J. M.

    2012-04-01

    In this work we are going to show the advantages of a dynamic tomography 4D, versus a static image 3D related with a volcanic reactivation and eruption at El Hierro island (Canary Islands, Spain). In this process a high number of earthquakes before and during the eruptive processes have been registered. We are going to show a 3D image as an average of the velocity structure and then the characteristics and physical properties on the medium, including the presence or not of magma. This image will be complemented with its evolution along the time, observing its volcanic dynamic and its influence over the medium properties, including its power as an important element on early warnings protocols. After more than forty years of quiet at Canary Islands, since 1971 with Teneguía eruption at La Palma Island, and more than 200 years on El Hierro Island (The last eruption known at El Hierro took place in 1793, volcán de Lomo Negro), on 19th July on 2011 the Spanish seismic national network, administered by IGN (Instituto Geográfico Nacional), detected an increase of local seismic activity below El Hierro island (Canary Islands, Spain). Since this moment an intense swarm took place, with more than 11000 events, until 11th December, with magnitudes (MLg) from 0.2 to 4.4. In this period two eruptive processes have been declared in front of the South coast of El Hierro island, and they have not finished yet. This seismic swarm has allowed carrying out a 3D seismic tomography, using P and S waves traveltimes. It has showed a low velocity from the North to the South. On the other hand, we have performed a 4D seismic tomography, taking the events occurred at different intervals of time. We can observe the evolution of the negative anomaly along the time, from the North to the South, where has taken place La Restinga submarine eruption. 4D seismic tomography is an innovative and powerful tool able to show the evolution in time of a volcanic process.

  13. El Hierro's floating stones as messengers of crust-magma interaction at depth

    NASA Astrophysics Data System (ADS)

    Burchardt, S.; Troll, V. R.; Schmeling, H.; Koyi, H.; Blythe, L. S.; Longpré, M. A.; Deegan, F. M.

    2012-04-01

    During the early stages of the submarine eruption that started on October 10 2011 south of El Hierro, Canary Islands, Spain, peculiar eruption products were found floating on the sea surface. These centimetre- to decimetre-sized "bombs" have been termed "restingolites" after the nearby village La Restinga and consist of a basaltic rind and a white to light grey core that resembles pumice in texture. According to Troll et al. (2011; see also Troll et al. EGU 2012 Abstracts), this material consists of a glassy matrix hosting extensive vesicle networks, which results in extremely low densities allowing these rocks to float on sea water. Mineralogical and geochemical analyses reveal that the "restingolites" originate from the sedimentary rocks (sand-, silt-, and mudstones) that form layer 1 of the oceanic crust beneath El Hierro. During the onset and early stages of the eruption, magma ponded at the base of this sedimentary sequence, breaking its way through the sedimentary rocks to the ocean floor. The textures of the "restingolites" reveal that crust-magma interaction during fragmentation and transport of the xenoliths involved rapid partial melting and volatile exsolution. Xenoliths strikingly similar to those from El Hierro are known from eruptions on other Canary Islands (e.g. La Palma, Gran Canaria, and Lanzarote). In fact, they resemble in texture xenoliths of various protoliths from volcanic areas worldwide (e.g. Krakatao, Indonesia, Cerro Quemado, Guatemala, Laacher See, Germany). This indicates that the process of partial melting and volatile exsolution, which the "restingolites" bear witness of, is probably occurring frequently during shallow crustal magma emplacement. Thermomechanical numerical models of the effect of the density decrease associated with the formation of vesicle networks in partially molten xenoliths show that xenoliths of crustal rocks initially sink in a magma chamber, but may start to float to the chamber roof once they start to heat up

  14. Magmatic sill intrusions beneath El Hierro Island following the 2011-2012 submarine eruption

    NASA Astrophysics Data System (ADS)

    Benito-Saz, María Á.; Sigmundsson, Freysteinn; Parks, Michelle M.; García-Cañada, Laura; Domínguez Cerdeña, Itahiza

    2016-04-01

    El Hierro, the most southwestern island of Canary Islands, Spain, is a volcano rising from around 3600 m above the ocean floor and up to of 1500 m above sea level. A submarine eruption occurred off the coast of El Hierro in 2011-2012, which was the only confirmed eruption in the last ~ 600 years. Activity continued after the end of the eruption with six magmatic intrusions occurring between 2012-2014. Each of these intrusions was characterized by hundreds of earthquakes and 3-19 centimeters of observed ground deformation. Ground displacements at ten continuous GPS sites were initially inverted to determine the optimal source parameters (location, geometry, volume/pressure change) that best define these intrusions from a geodetic point of view. Each intrusive period appears to be associated with the formation of a separate sill, with inferred volumes between 0.02 - 0.3 km3. SAR images from the Canadian RADARSAT-2 satellite and the Italian Space Agency COSMO-SkyMed constellation have been used to produce high-resolution detailed maps of line-of-sight displacements for each of these intrusions. These data have been combined with the continuous GPS observations and a joint inversion undertaken to gain further constraints on the optimal source parameters for each of these separate intrusive events. The recorded activity helps to understand how an oceanic intraplate volcanic island grows through repeated sill intrusions; well documented by seismic, GPS and InSAR observations in the case of the El Hierro activity.

  15. Volcanic Alert System (VAS) developed during the (2011-2013) El Hierro (Canary Islands) volcanic process

    NASA Astrophysics Data System (ADS)

    Ortiz, Ramon; Berrocoso, Manuel; Marrero, Jose Manuel; Fernandez-Ros, Alberto; Prates, Gonçalo; De la Cruz-Reyna, Servando; Garcia, Alicia

    2014-05-01

    In volcanic areas with long repose periods (as El Hierro), recently installed monitoring networks offer no instrumental record of past eruptions nor experience in handling a volcanic crisis. Both conditions, uncertainty and inexperience, contribute to make the communication of hazard more difficult. In fact, in the initial phases of the unrest at El Hierro, the perception of volcanic risk was somewhat distorted, as even relatively low volcanic hazards caused a high political impact. The need of a Volcanic Alert System became then evident. In general, the Volcanic Alert System is comprised of the monitoring network, the software tools for the analysis of the observables, the management of the Volcanic Activity Level, and the assessment of the threat. The Volcanic Alert System presented here places special emphasis on phenomena associated to moderate eruptions, as well as on volcano-tectonic earthquakes and landslides, which in some cases, as in El Hierro, may be more destructive than an eruption itself. As part of the Volcanic Alert System, we introduce here the Volcanic Activity Level which continuously applies a routine analysis of monitoring data (particularly seismic and deformation data) to detect data trend changes or monitoring network failures. The data trend changes are quantified according to the Failure Forecast Method (FFM). When data changes and/or malfunctions are detected, by an automated watchdog, warnings are automatically issued to the Monitoring Scientific Team. Changes in the data patterns are then translated by the Monitoring Scientific Team into a simple Volcanic Activity Level, that is easy to use and understand by the scientists and technicians in charge for the technical management of the unrest. The main feature of the Volcanic Activity Level is its objectivity, as it does not depend on expert opinions, which are left to the Scientific Committee, and its capabilities for early detection of precursors. As a consequence of the El Hierro

  16. Structural interpretation of El Hierro (Canary Islands) rifts system from gravity inversion modelling

    NASA Astrophysics Data System (ADS)

    Sainz-Maza, S.; Montesinos, F. G.; Martí, J.; Arnoso, J.; Calvo, M.; Borreguero, A.

    2017-08-01

    Recent volcanism in El Hierro Island is mostly concentrated along three elongated and narrow zones which converge at the center of the island. These zones with extensive volcanism have been identified as rift zones. The presence of similar structures is common in many volcanic oceanic islands, so understanding their origin, dynamics and structure is important to conduct hazard assessment in such environments. There is still not consensus on the origin of the El Hierro rift zones, having been associated with mantle uplift or interpreted as resulting from gravitational spreading and flank instability. To further understand the internal structure and origin of the El Hierro rift systems, starting from the previous gravity studies, we developed a new 3D gravity inversion model for its shallower layers, gathering a detailed picture of this part of the island, which has permitted a new interpretation about these rifts. Previous models already identified a main central magma accumulation zone and several shallower high density bodies. The new model allows a better resolution of the pathways that connect both levels and the surface. Our results do not point to any correspondence between the upper parts of these pathways and the rift identified at the surface. Non-clear evidence of progression toward deeper parts into the volcanic system is shown, so we interpret them as very shallow structures, probably originated by local extensional stresses derived from gravitational loading and flank instability, which are used to facilitate the lateral transport of magma when it arrives close to the surface.

  17. Monitoring diffuse degassing in monogentic volcanic field during magmatic reactivation: the case of El Hierro (Canary Islands, Spain)

    NASA Astrophysics Data System (ADS)

    Morales-Ocaña, C.; Feldman, R. C.; Pointer, Z. R.; Rodríguez, F.; Asensio-Ramos, M.; Melián, G.; Padrón, E.; Hernández, P. A.; Pérez, N. M.

    2017-12-01

    El Hierro (278 km2), the younger, smallest and westernmost island of the Canarian archipelago, is a 5-km-high edifice constructed by rapid constructive and destructive processes in 1.12 Ma, with a truncated trihedron shape and three convergent ridges of volcanic cones. It experienced a submarine eruption from 12 October, 2011 and 5 March 2012, off its southern coast that was the first one to be monitored from the beginning in the Canary Islands. As no visible emanations occur at the surface environment of El Hierro, diffuse degassing studies have become a useful geochemical tool to monitor the volcanic activity in this volcanic island. Diffuse CO2 emission has been monitored at El Hierro Island since 1998 in a yearly basis, with much higher frequency in the period 2011-2012. At each survey, about 600 sampling sites were selected to obtain a homogeneous distribution. Measurements of soil CO2 efflux were performed in situ following the accumulation chamber method. During pre-eruptive and eruptive periods, the diffuse CO2 emission released by the whole island experienced significant increases before the onset of the submarine eruption and the most energetic seismic events of the volcanic-seismic unrest (Melián et al., 2014. J. Geophys. Res. Solid Earth, 119, 6976-6991). The soil CO2 efflux values of the 2017 survey ranged from non-detectable to 53.1 g m-2 d-1. Statistical-graphical analysis of the data show two different geochemical populations; background (B) and peak (P) represented by 77.6% and 22.4% of the total data, respectively, with geometric means of 1.8 and 9.2 g m-2 d-1, respectively. Most of the area showed B values while the P values were mainly observed at the interception center of the three convergent ridges and the north of the island. To estimate the diffuse CO2 emission for the 2017 survey, we ran about 100 sGs simulations. The estimated 2017 diffuse CO2 output released to atmosphere by El Hierro was at 1,150 ± 42 t d-1, value higher than the

  18. Forecasting the 2011 El Hierro submarine eruption (Canary Islands) on the basis of soil He degassing surveys

    NASA Astrophysics Data System (ADS)

    Padrón, E.; Pérez, N. M.; Hernández, P. A.; Melián, G. V.; Padilla, G. D.; Barrancos, J.; Dionis, S.; Rodríguez, F.; Nolasco, D.; Calvo, D.; Hernández, I.; Peraza, M. D.

    2012-04-01

    El Hierro Island is the southwesternmost and the youngest island of the Canary archipelago. Since 16 July, an anomalous seismicity at El Hierro island was recorded by IGN seismic network. After the occurrence of more than 10,000 seismic events, volcanic tremor was recorded since 05:15 of the October 10, by all of the seismic stations on the island, with highest amplitudes recorded in the southernmost station. During the afternoon of 12 October a large light-green coloured area was observed in the sea to the souht of La Restinga village (at the southernmost part of El Hierro island), suggesting the existence of a submarine eruption. Since October 12, frequent episodes of, turbulent gas emission and foaming, and the appearance of steamy lava fragments has been observed on the sea surface. As part of the volcanic surveillance of the island, the Instituto Volcanologico de Canarias (INVOLCAN) geochemical monitoring program is carrying out diffuse helium surveys on the surface environment of El Hierro (soil atmosphere). This nobel gas has been investigated because it has been considered an almost ideal geochemical indicator because it is chemically inert, physically stable, nonbiogenic, sparingly soluble in water under ambient conditions and almost non-adsorbable. At each survey, 600 sampling sites covering the whole island and following an homogeneous distribution are selected for helium measurements in the soil gases, The helium concentration gradients with respect to its value on air (5.24 ppm) allow us to estimate a pure diffusive emission rate of helium throughout the island. The first survey was carried out on the summer of 2003, when the island was on a quiescence period. At this survey, the amount of helium released by the volcanic system of El Hierro was estimated in 6 kg/d. Since the beginning of the seismic unrest, 13 helium emission surveys have been carried out. The helium emission rate has shown an excellent agreement with the evolution of the volcanic

  19. Study of the thermohygrometric conditions of Juniperus turbinata habitat in the island of El Hierro (Canary Islands)

    NASA Astrophysics Data System (ADS)

    Salva-Catarineu, Montserrat; Salvador-Franch, Ferran; López-Bustins, Joan Albert; Padrón-Padrón, Perdro A.; Cortés-Lucas, Amparo

    2015-04-01

    The biggest population of Juniperus turbinata throughout the Canary Islands is located in the island of El Hierro. The current extent of juniper woodlands is very small compared with the potential distribution due to heavy exploitation for centuries. Nowadays, the recovery of its natural habitat has such a high environmental and scenic interest since this is a protected species in Europe; however, an improved understanding of the environmental factors that help or limit its recovery is indispensable. Under the JUNITUR project the populations of juniper woodlands in El Hierro are being studied, which are subjected to highly different environments. These environments are mainly determined by their altitude and exposure to NE trade winds. The main objective of this study is to compare the thermohygrometric conditions of three juniper woodlands, located at different altitude and orientation in El Hierro, which present different recovery rates. We are currently using air sensor data loggers fixed to tree branches for recording hourly temperature and humidity data in the three study areas. For this preliminary approach, we analyse daily data of two annual cycles (from September 2012 to August 2014). Our first results show similar thermohygrometric annual cycles among the three study areas. The largest differences are detected in winter temperature and summer humidity between the north (to windward) and south (to leeward) faces of the island. The juniper woodland with a highest recovery rate shows the most extreme temperature conditions in both winter and summer seasons. This last juniper woodland is located leeward to trade winds at 996 m a.s.l. In general terms, the results of this research project might contribute to the knowledge of the juniper bioclimatology in the westernmost of the Canary Islands. Key words: bioclimatology, El Hierro, habitat, Juniperus turbinata, protected species

  20. Soil gas 222Rn and volcanic activity at El Hierro (Canary Islands) before and after the 2011 submarine eruption

    NASA Astrophysics Data System (ADS)

    Padilla, G.; Hernández, P. A.; Padrón, E.; Barrancos, J.; Melián, G.; Dionis, S.; Rodríguez, F.; Nolasco, D.; Calvo, D.; Hernández, I.; Pereza, M. D.; Pérez, N. M.

    2012-04-01

    El Hierro (278 km2) is the southwesternmost island of the Canarian archipelago. From June 19, 2011 to January 2012, more than 11,950 seismic events have been detected by the seismic network of IGN. On 10 October 2011 the earthquake swarm changed its behaviour and produced a harmonic tremor due to magma movement, indicating that a submarine eruption located at 2 km south of La Restinga had started which is still in progress. Since 2003, the ITER Environmental Research Division now integrated in the Instituto Volcanológico de Canarias, INVOLCAN, has regularly performed soil gas surveys at El Hierro as a geochemical tool for volcanic surveillance. Among the investigated gases, soil gas radon (222Rn) and thoron (220Rn) have played a special attention. Both gases are characterized to ascend towards the surface mainly through cracks or faults via diffusion or advection, mechanisms dependent of both soil porosity and permeability, which in turn vary as a function of the stress/strain changes at depth. Years before the starts of the volcanic-seismic crisis on July 17, 2011, a volcanic multidisciplinary surveillance program was implemented at El Hierro including discrete and continuous measurements of 222Rn and 220Rn. Two soil gas 222Rn surveys had been carried out at El Hierro in 2003 and 2011, and four continuous geochemical monitoring stations for 222Rn and 220Rn measurements had been installed (HIE02, HIE03, HIE04 and HIE08). Soil gas 222Rn surveys were carried out at the surface environment of El Hierro after selecting 600 sampling observation sites (about 40 cm depth). Geochemical stations measure 222Rn and 220Rn activities by pumping the gas from a PVC pipe inserted 1m in the ground and thermally isolated. The results of the 2003 and 2011 soil gas 222Rn surveys show clearly a relatively higher observed 222Rn activities in the surface environment on 2011 than those observed on 2003 when no anomalous seismicity were taking place beneath El Hierro. The observed

  1. Precursory diffuse CO2 emission signature of the 2011 El Hierro submarine eruption, Canary Islands

    NASA Astrophysics Data System (ADS)

    Pérez, N. M.; Padilla, G. D.; Padrón, E.; Hernández, P. A.; Melián, G. V.; Barrancos, J.; Dionis, S.; Rodríguez, F.; Nolasco, D.; Calvo, D.; Hernández, I.; Peraza, M. D.

    2012-04-01

    El Hierro is the youngest and southernmost island of the Canarian archipelago and represents the summit of a volcanic shield elevating from the surrounding seafloor at depth of 4000 m to up to 1501 m above sea level. The island is believed to be near the present hotspot location in the Canaries with the oldest subaerial rocks dated at 1.12 Ma. The subaerial parts of the El Hierro rift zones (NE, NW and S Ridges) are characterized by tightly aligned dyke complexes with clusters of cinder cones as their surface expressions. Since 16 July, an anomalous seismicity at El Hierro Island was recorded by IGN seismic network. Volcanic tremor started at 05:15 on 10 October, followed on the afternoon of 12 October by a green discolouration of seawater, strong bubbling and degassing, and abundant bombs on a decimetre scale found floating on the ocean surface offshore, southwest of La Restinga village, indicating the occurrence of a submarine volcanic eruption at approximately 2 km far the coast line of La Restinga. Further episodes have occurred during November, December 2011 and January 2012, with turbulent water, foam rings, and volcanic material again reaching the sea surface. In order to improve the volcanic surveillance program of El Hierro Island and to provide a multidisciplinary approach, a continuous geochemical station to measure CO2 efflux was installed on September 2003 in Llanos de Guillen, the interception center of the three volcanic-rift zones of the island, with the aim of detecting changes in the diffuse emission of CO2 related to the seismic or volcanic activity. The station measures on an hourly basis the CO2 and H2S efflux, the CO2 and H2S air concentrations, the soil water content and temperature and the atmospheric parameters: wind speed and direction, air temperature and humidity and barometric pressure. The meteorological parameters together with the air CO2 concentration are measured 1 m above the ground and the soil water content and soil temperature

  2. Analysis of surface deformation during the eruptive process of El Hierro Island (Canary Islands, Spain): Detection, Evolution and Forecasting.

    NASA Astrophysics Data System (ADS)

    Berrocoso, M.; Fernandez-Ros, A.; Prates, G.; Martin, M.; Hurtado, R.; Pereda, J.; Garcia, M. J.; Garcia-Cañada, L.; Ortiz, R.; Garcia, A.

    2012-04-01

    The surface deformation has been an essential parameter for the onset and evolution of the eruptive process of the island of El Hierro (October 2011) as well as for forecasting changes in seismic and volcanic activity during the crisis period. From GNSS-GPS observations the reactivation is early detected by analizing the change in the deformation of the El Hierro Island regional geodynamics. It is found that the surface deformation changes are detected before the occurrence of seismic activity using the station FRON (GRAFCAN). The evolution of the process has been studied by the analysis of time series of topocentric coordinates and the variation of the distance between stations on the island of El Hierro (GRAFCAN station;IGN network; and UCA-CSIC points) and LPAL-IGS station on the island of La Palma. In this work the main methodologies and their results are shown: •The location (and its changes) of the litospheric pressure source obtained by applying the Mogi model. •Kalman filtering technique for high frequency time series, used to make the forecasts issued for volcanic emergency management. •Correlations between deformation of the different GPS stations and their relationship with seismovolcanic settings.

  3. Influence of the submarine volcanic eruption off El Hierro (Canary Islands) on the mesopelagic cephalopod's metal content.

    PubMed

    Lozano-Bilbao, Enrique; Gutiérrez, Ángel José; Hardisson, Arturo; Rubio, Carmen; González-Weller, Dailos; Aguilar, Natacha; Escánez, Alejandro; Espinosa, José María; Canales, Paula; Lozano, Gonzalo

    2018-04-01

    This work investigates whether a submarine volcanic eruption off El Hierro (Canary Islands) in October 2011 influenced the metal contents of two deep water cephalopod species: Abraliopsis morisii and Pyroteuthis margaritifera. This was assessed by comparing metal contents in specimens collected off the island of El Hierro and in the neighbouring islands of La Palma and Tenerife during an experimental deep water fishing trip. The concentration of 20 heavy metals was analyzed in 180 specimens of A. morisii and P. margaritifera collected around the three islands to test for inter-island differences for each species and metal. While both species showed geographical differences in metal concentrations, the main finding was that A. morisii could be a bioindicator species for metals such as Li, Sr and Ca. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Driving magma to the surface: The 2011-2012 El Hierro Volcanic Eruption

    NASA Astrophysics Data System (ADS)

    López, Carmen; Benito-Saz, Maria A.; Martí, Joan; del-Fresno, Carmen; García-Cañada, Laura; Albert, Helena; Lamolda, Héctor

    2017-08-01

    We reanalyzed the seismic and deformation data corresponding to the preeruptive unrest on El Hierro (Canary Islands) in 2011. We considered new information about the internal structure of the island. We updated the seismic catalog to estimate the full evolution of the released seismic energy and demonstrate the importance of nonlocated earthquakes. Using seismic data and GPS displacements, we characterized the shear-tensile type of the predominant fracturing and modeled the strain and stress fields for different time periods. This enabled us to identify a prolonged first phase characterized by hydraulic tensile fracturing, which we interpret as being related to the emplacement of new magma below the volcanic edifice on El Hierro. This was followed by postinjection unidirectional migration, probably controlled by the stress field and the distribution of the structural discontinuities. We identified the effects of energetic magmatic pulses occurring a few days before the eruption that induced shear seismicity on preexisting faults within the volcano and raised the Coulomb stress over the whole crust. We suggest that these magmatic pulses reflect the crossing of the Moho discontinuity, as well as changes in the path geometry of the dyke migration toward the surface. The final phase involved magma ascent through a prefractured crust.

  5. Evidence from acoustic imaging for submarine volcanic activity in 2012 off the west coast of El Hierro (Canary Islands, Spain)

    NASA Astrophysics Data System (ADS)

    Pérez, Nemesio M.; Somoza, Luis; Hernández, Pedro A.; de Vallejo, Luis González; León, Ricardo; Sagiya, Takeshi; Biain, Ander; González, Francisco J.; Medialdea, Teresa; Barrancos, José; Ibáñez, Jesús; Sumino, Hirochika; Nogami, Kenji; Romero, Carmen

    2014-12-01

    We report precursory geophysical, geodetic, and geochemical signatures of a new submarine volcanic activity observed off the western coast of El Hierro, Canary Islands. Submarine manifestation of this activity has been revealed through acoustic imaging of submarine plumes detected on the 20-kHz chirp parasound subbottom profiler (TOPAS PS18) mounted aboard the Spanish RV Hespérides on June 28, 2012. Five distinct "filament-shaped" acoustic plumes emanating from the flanks of mounds have been recognized at water depth between 64 and 88 m on a submarine platform located NW El Hierro. These plumes were well imaged on TOPAS profiles as "flares" of high acoustic contrast of impedance within the water column. Moreover, visible plumes composed of white rafts floating on the sea surface and sourcing from the location of the submarine plumes were reported by aerial photographs on July 3, 2012, 5 days after acoustic plumes were recorded. In addition, several geophysical and geochemical data support the fact that these submarine vents were preceded by several precursory signatures: (i) a sharp increase of the seismic energy release and the number of daily earthquakes of magnitude ≥2.5 on June 25, 2012, (ii) significant vertical and horizontal displacements observed at the Canary Islands GPS network (Nagoya University-ITER-GRAFCAN) with uplifts up to 3 cm from June 25 to 26, 2012, (iii) an anomalous increase of the soil gas radon activity, from the end of April until the beginning of June reaching peak values of 2.7 kBq/m3 on June 3, 2012, and (iv) observed positive peak in the air-corrected value of 3He/4He ratio monitored in ground waters (8.5 atmospheric 3He/4He ratio ( R A)) at the northwestern El Hierro on June 16, 2012. Combining these submarine and subaerial information, we suggest these plumes are the consequence of submarine vents exhaling volcanic gas mixed with fine ash as consequence of an event of rapid rise of volatile-rich magma beneath the NW submarine ridge

  6. Physico-chemical changes of the ground waters related to the 2011 El Hierro magmatic reactivation

    NASA Astrophysics Data System (ADS)

    Dionis, S.; Melián, G.; Padrón, E.; Padilla, G.; Nolasco, D.; Rodríguez, F.; Hernández, I.; Peraza, D.; Barrancos, J.; Hernández, P.; Calvo, D.; Pérez, N.

    2012-04-01

    The island of El Hierro (278 Km2), is the smallest, the southwesternmost and the youngest island (˜1.12 My) of the Canarian archipelago. The main geological characteristics of El Hierro consist on the presence of three convergent ridges of volcanic cones on a truncated trihedron shape and giant landslides between the three rift zones, being the most recent El Golfo on the northwest flank of the island. On July 2011 an anomalous seismic activity at Hierro Island started and suggested the initial stage of a volcanic unrest in the volcanic system. On October 10, after the occurrence of more than 10,000 earthquakes, a submarine eruption started. Evidences of this submarine volcanic eruption were visible on the sea surface to the south of La Restinga village, at the south of the island, in the form of large light-green coloured area, turbulent gas emission and the appearance of steamy volcanic fragments three days later. As part of its volcanic surveillance activities, the Instituto Volcanologico de Canarias (INVOLCAN) started a hydrogeochemical monitoring program on August 2011 in order to evaluate the temporal evolution of several physico-chemical parameters of the ground water system of El Hierro. Four observation sites were selected: three wells on the north of the island, where the seismic activity was located at the beginning of the volcano-seismic unrest (SIMO, FRON and PADO) and one horizontal well (gallery) in the south (TACO). Ground water sampling is being regularly collected, three times per week, at each observation site, and in-situ measurements of pH, conductivity and temperature measurements are performed. After 6 month of monitoring, no significant changes have been observed on pH and temperature measurements from all the observation sites. However, clear sharp decrease of conductivity was observed at SIMO on October 10 when the seismic tremor started. In addition, the strongest conductivity decrease pattern was observed later on at SIMO and PADO on

  7. Xenopumice erupted on 15 October 2011 offshore of El Hierro (Canary Islands): a subvolcanic snapshot of magmatic, hydrothermal and pyrometamorphic processes

    NASA Astrophysics Data System (ADS)

    Del Moro, S.; Di Roberto, A.; Meletlidis, S.; Pompilio, M.; Bertagnini, A.; Agostini, S.; Ridolfi, F.; Renzulli, A.

    2015-06-01

    On 15 October 2011, a submarine eruption offshore of El Hierro Island gave rise to floating volcanic products, known as xenopumices, i.e., pumiceous xenoliths partly mingled and coated with the juvenile basanitic magma. Over the last few years, no consensus in the scientific community in explaining the origin of these products has been reached. In order to better understand the formation of xenopumice, we present a textural, mineralogical, and geochemical study of the possible magmatic, hydrothermal, and pyrometamorphic processes, which usually operate in the plumbing systems of active volcanoes. We carried out a comprehensive SEM investigation and Sr-Nd-Pb isotope analyses on some samples representative of three different xenopumice facies. All the data were compared with previous studies, new data for El Hierro extrusives and a literature dataset of Canary Islands igneous and sedimentary rocks. In the investigated xenopumices, we emphasize the presence of restitic magmatic phases as well as crystallization of minerals (mainly olivine + pyroxene + magnetite aggregates) as pseudomorphs after pre-existing mafic phenocrysts, providing evidence of pyrometamorphism induced by the high-T juvenile basanitic magma. In addition, we identify veins consisting of zircon + REE-oxides + mullite associated with Si-rich glass and hydrothermal quartz, which indicate the fundamental role played by hydrothermal fluid circulation in the xenopumice protolith. The petrological data agree with a pre-syneruptive formation of the xenopumice, when El Hierro basanite magma intruded hydrothermally altered trachyandesite to trachyte rocks and triggered local partial melting. Therefore, the El Hierro xenopumice represents a snapshot of the transient processes at the magma-wall rock interface, which normally occurs in the feeding system of active volcanoes.

  8. Volcanic alert system (VAS) developed during the 2011-2014 El Hierro (Canary Islands) volcanic process

    NASA Astrophysics Data System (ADS)

    García, Alicia; Berrocoso, Manuel; Marrero, José M.; Fernández-Ros, Alberto; Prates, Gonçalo; De la Cruz-Reyna, Servando; Ortiz, Ramón

    2014-06-01

    The 2011 volcanic unrest at El Hierro Island illustrated the need for a Volcanic Alert System (VAS) specifically designed for the management of volcanic crises developing after long repose periods. The VAS comprises the monitoring network, the software tools for analysis of the monitoring parameters, the Volcanic Activity Level (VAL) management, and the assessment of hazard. The VAS presented here focuses on phenomena related to moderate eruptions, and on potentially destructive volcano-tectonic earthquakes and landslides. We introduce a set of new data analysis tools, aimed to detect data trend changes, as well as spurious signals related to instrumental failure. When data-trend changes and/or malfunctions are detected, a watchdog is triggered, issuing a watch-out warning (WOW) to the Monitoring Scientific Team (MST). The changes in data patterns are then translated by the MST into a VAL that is easy to use and understand by scientists, technicians, and decision-makers. Although the VAS was designed specifically for the unrest episodes at El Hierro, the methodologies may prove useful at other volcanic systems.

  9. Nannofossils in 2011 El Hierro eruptive products reinstate plume model for Canary Islands

    NASA Astrophysics Data System (ADS)

    Zaczek, Kirsten; Troll, Valentin R.; Cachao, Mario; Ferreira, Jorge; Deegan, Frances M.; Carracedo, Juan Carlos; Soler, Vicente; Meade, Fiona C.; Burchardt, Steffi

    2015-01-01

    The origin and life cycle of ocean islands have been debated since the early days of Geology. In the case of the Canary archipelago, its proximity to the Atlas orogen led to initial fracture-controlled models for island genesis, while later workers cited a Miocene-Quaternary east-west age-progression to support an underlying mantle-plume. The recent discovery of submarine Cretaceous volcanic rocks near the westernmost island of El Hierro now questions this systematic age-progression within the archipelago. If a mantle-plume is indeed responsible for the Canaries, the onshore volcanic age-progression should be complemented by progressively younger pre-island sedimentary strata towards the west, however, direct age constraints for the westernmost pre-island sediments are lacking. Here we report on new age data obtained from calcareous nannofossils in sedimentary xenoliths erupted during the 2011 El Hierro events, which date the sub-island sedimentary rocks to between late Cretaceous and Pliocene in age. This age-range includes substantially younger pre-volcanic sedimentary rocks than the Jurassic to Miocene strata known from the older eastern islands and now reinstate the mantle-plume hypothesis as the most plausible explanation for Canary volcanism. The recently discovered Cretaceous submarine volcanic rocks in the region are, in turn, part of an older, fracture-related tectonic episode.

  10. Nannofossils in 2011 El Hierro eruptive products reinstate plume model for Canary Islands.

    PubMed

    Zaczek, Kirsten; Troll, Valentin R; Cachao, Mario; Ferreira, Jorge; Deegan, Frances M; Carracedo, Juan Carlos; Soler, Vicente; Meade, Fiona C; Burchardt, Steffi

    2015-01-22

    The origin and life cycle of ocean islands have been debated since the early days of Geology. In the case of the Canary archipelago, its proximity to the Atlas orogen led to initial fracture-controlled models for island genesis, while later workers cited a Miocene-Quaternary east-west age-progression to support an underlying mantle-plume. The recent discovery of submarine Cretaceous volcanic rocks near the westernmost island of El Hierro now questions this systematic age-progression within the archipelago. If a mantle-plume is indeed responsible for the Canaries, the onshore volcanic age-progression should be complemented by progressively younger pre-island sedimentary strata towards the west, however, direct age constraints for the westernmost pre-island sediments are lacking. Here we report on new age data obtained from calcareous nannofossils in sedimentary xenoliths erupted during the 2011 El Hierro events, which date the sub-island sedimentary rocks to between late Cretaceous and Pliocene in age. This age-range includes substantially younger pre-volcanic sedimentary rocks than the Jurassic to Miocene strata known from the older eastern islands and now reinstate the mantle-plume hypothesis as the most plausible explanation for Canary volcanism. The recently discovered Cretaceous submarine volcanic rocks in the region are, in turn, part of an older, fracture-related tectonic episode.

  11. Heterogeneous vesiculation of 2011 El Hierro xeno-pumice revealed by X-ray computed microtomography

    NASA Astrophysics Data System (ADS)

    Berg, S. E.; Troll, V. R.; Deegan, F. M.; Burchardt, S.; Krumbholz, M.; Mancini, L.; Polacci, M.; Carracedo, J. C.; Soler, V.; Arzilli, F.; Brun, F.

    2016-12-01

    During the first week of the 2011 El Hierro submarine eruption, abundant light-coloured pumiceous, high-silica volcanic bombs coated in dark basanite were found floating on the sea. The composition of the light-coloured frothy material (`xeno-pumice') is akin to that of sedimentary rocks from the region, but the textures resemble felsic magmatic pumice, leaving their exact mode of formation unclear. To help decipher their origin, we investigated representative El Hierro xeno-pumice samples using X-ray computed microtomography for their internal vesicle shapes, volumes, and bulk porosity, as well as for the spatial arrangement and size distributions of vesicles in three dimensions (3D). We find a wide range of vesicle morphologies, which are especially variable around small fragments of rock contained in the xeno-pumice samples. Notably, these rock fragments are almost exclusively of sedimentary origin, and we therefore interpret them as relicts an the original sedimentary ocean crust protolith(s). The irregular vesiculation textures observed probably resulted from pulsatory release of volatiles from multiple sources during xeno-pumice formation, most likely by successive release of pore water and mineral water during incremental heating and decompression of the sedimentary protoliths.

  12. Dissolved gas geochemical signatures of the ground waters related to the 2011 El Hierro magmatic reactivation

    NASA Astrophysics Data System (ADS)

    Rodríguez, F.; Hernández, P. A.; Padrón, E.; Pérez, N. M.; Sumino, H.; Melián, G. V.; Padilla, G. D.; Barrancos, J.; Dionis, S.; Nolasco, D.; Calvo, D.; Hernández, I.; Peraza, M. D.

    2012-04-01

    El Hierro Island is the south westernmost and the youngest island of the Canary archipelago (<1.2 My). Since 16 July, an anomalous seismicity at El Hierro Island was recorded by IGN seismic network. After the occurrence of more than 10,000 seismic events, volcanic tremor was recorded since 05:15 on October 10, by all of the seismic stations on the island, with highest amplitudes recorded in the southernmost station. During the afternoon of 12 October a large light-green coloured area was observed in the sea to the south of La Restinga village (at the southernmost part of El Hierro island), suggesting the existence of a submarine eruption. Since October 12, frequent episodes of, turbulent gas emission and foaming, and the appearance of steamy lava fragments has been observed on the sea surface. Instituto Volcanologico de Canarias (INVOLCAN) started a hydrogeochemical program on August 2011 in order to evaluate the temporal evolution of dissolved gases on four different observation points (vertical and horizontal wells) of El Hierro. Three wells are located on the north of the island (where the seismic activity occurred at the beginning of the volcano-seismic unrest) and one horizontal well (gallery) in the south. At each observation point the concentration of dissolved helium, CO2, N2, O2 and Ar and the isotopic composition of He, C-CO2 and Ar have been measured three times per week. Significant increases on the dissolved gases content, mainly on CO2 and He/CO2 ratio, have been measured at all the observation points prior to the increasing of released seismic energy. Isotopic composition of dissolved helium, measured as 3He/4He ratio, showed an significant increase (from 1-3 RA up to 7.2 RA, being RA the isotopic 3He/4He ratio on air) at all the observation points 20 days before the occurrence of the submarine eruption and these relatively high 3He/4He values have been maintained along the volcanic unrest period. The isotopic composition of CO2 has showed also

  13. Diffuse degassing He/CO2 ratio before and during the 2011-12 El Hierro submarine eruption, Canary Islands

    NASA Astrophysics Data System (ADS)

    Padrón, Eleazar; Hernández, Pedro A.; Melián, Gladys V.; Barrancos, José; Padilla, Germán; Pérez, Nemesio M.; Dionis, Samara; Rodríguez, Fátima; Asensio-Ramos, María; Calvo, David

    2015-04-01

    El Hierro Island (278 km2) is the youngest and the SW-most of the Canary Islands. On July 16, 2011, a seismic-volcanic crisis started with the occurrence of more than 11,900 seismic events and significant deformation along the island, culminating with the eruption onset in October 12. Since at El Hierro Islands there are not any surface geothermal manifestation (fumaroles, etc), we have focused our studies on soil degassing surveys. Between July 2011 to March 2012, seventeen diffuse CO2 and He emissions soil gas surveys were undertaken at El Hierro volcanic system (600 observation sites) with the aim to investigate the relationship between their temporal variations and the volcanic activity (Padrón et al., 2013; Melián et al., 2014). Based on the diffuse He/CO2 emission ratio, a sharp increase before the eruption onset was observed, reaching the maximum value on September 26 (6.8×10-5), sixteen days before the occurrence of the eruption. This increase coincided with an increase in seismic energy release during the volcanic unrest and occurred together with an increase on the 3He/4He isotopic ratio in groundwaters from a well in El Hierro Island (Padrón et al., 2013; from 2-3 RA to 7.2 RA where RA = 3He/4He ratio in air), one month prior to the eruption onset. Early degassing of new gas-rich magma batch at depth could explain the observed increase on the He/CO2 ratio, causing a preferential partitioning of CO2 in the gas phase with respect to the He, due to the lower solubility of CO2 than that of He in basaltic magmas. During the eruptive period (October 2011-March 2012) the prevalence of a magmatic CO2-dominated component is evident, as indicated by the generally lower He/CO2 ratios and high 3He/4He values (Padrón et al., 2013). The onset of the submarine eruption might have produced a sudden release of volcanic gases, and consequently, a decrease in the volcanic gas pressure of the magma bodies moving beneath the island, reflected by a drastic decrease in

  14. Diffuse CO_{2} degassing monitoring of the oceanic active volcanic island of El Hierro, Canary Islands, Spain

    NASA Astrophysics Data System (ADS)

    Hernández, Pedro A.; Norrie, Janice; Withoos, Yannick; García-Merino, Marta; Melián, Gladys; Padrón, Eleazar; Barrancos, José; Padilla, Germán; Rodríguez, Fátima; Pérez, Nemesio M.

    2017-04-01

    Even during repose periods, volcanoes release large amounts of gases from both visible (fumaroles, solfataras, plumes) and non-visible emanations (diffuse degassing). In the last 20 years, there has been considerable interest in the study of diffuse degassing as a powerful tool in volcano monitoring programs, particularly in those volcanic areas where there are no visible volcanic-hydrothermal gas emissions. Historically, soil gas and diffuse degassing surveys in volcanic environments have focused mainly on CO2 because it is, after water vapor, the most abundant gas dissolved in magma. As CO2 travels upward by advective-diffusive transport mechanisms and manifests itself at the surface, changes in its flux pattern over time provide important information for monitoring volcanic and seismic activity. Since 1998, diffuse CO2 emission has been monitored at El Hierro Island, the smallest and south westernmost island of the Canarian archipelago with an area of 278 km2. As no visible emanations occur at the surface environment of El Hierro, diffuse degassing studies have become the most useful geochemical tool to monitor the volcanic activity in this volcanic island. The island experienced a volcano-seismic unrest that began in July 2011, characterized by the location of a large number of relatively small earthquakes (M<2.5) beneath El Hierro at depths between 8 and 15 km. On October 12, 2011, a submarine eruption was confirmed during the afternoon of October 12, 2011 by visual observations off the coast of El Hierro, about 2 km south of the small village of La Restinga in the southernmost part of the island. During the pre-eruptive and eruptive periods, the time series of the diffuse CO2 emission released by the whole island experienced two significant increases. The first started almost 2 weeks before the onset of the submarine eruption, reflecting a clear geochemical anomaly in CO2 emission, most likely due to increasing release of deep seated magmatic gases to the

  15. Seismic tomography model reveals mantle magma sources of recent volcanic activity at El Hierro Island (Canary Islands, Spain)

    NASA Astrophysics Data System (ADS)

    García-Yeguas, Araceli; Ibáñez, Jesús M.; Koulakov, Ivan; Jakovlev, Andrey; Romero-Ruiz, M. Carmen; Prudencio, Janire

    2014-12-01

    We present a 3-D model of P and S velocities beneath El Hierro Island, constructed using the traveltime data of more than 13 000 local earthquakes recorded by the Instituto Geográfico Nacional (IGN, Spain) in the period from 2011 July to 2012 September. The velocity models were performed using the LOTOS code for iterative passive source tomography. The results of inversion were thoroughly verified using different resolution and robustness tests. The results reveal that the majority of the onshore area of El Hierro is associated with a high-velocity anomaly observed down to 10-12-km depth. This anomaly is interpreted as the accumulation of solid igneous rocks erupted during the last 1 Myr and intrusive magmatic bodies. Below this high-velocity pattern, we observe a low-velocity anomaly, interpreted as a batch of magma coming from the mantle located beneath El Hierro. The boundary between the low- and high-velocity anomalies is marked by a prominent seismicity cluster, thought to represent anomalous stresses due to the interaction of the batch of magma with crust material. The areas of recent eruptions, Orchilla and La Restinga, are associated with low-velocity anomalies surrounding the main high-velocity block. These eruptions took place around the island where the crust is much weaker than the onshore area and where the melted material cannot penetrate. These results put constraints on the geological model that could explain the origin of the volcanism in oceanic islands, such as in the Canaries, which is not yet clearly understood.

  16. Cyclic thermal behavior associated to the degassing process at El Hierro submarine volcano, Canary Islands.

    NASA Astrophysics Data System (ADS)

    Fraile-Nuez, E.; Santana-Casiano, J. M.; González-Dávila, M.

    2016-12-01

    One year after the ceasing of magmatic activity in the shallow submarine volcano of the island of El Hierro, significant physical-chemical anomalies produced by the degassing process as: (i) thermal anomalies increase of +0.44 °C, (ii) pH decrease of -0.034 units, (iii) total dissolved inorganic carbon, CT increase by +43.5 µmol kg-1 and (iv) total alkalinity, AT by +12.81 µmol kg-1 were still present in the area. These evidences highlight the potential role of the shallow degassing processes as a natural ecosystem-scale experiments for the study of significant effects of global change stressors on marine environments. Additionally, thermal time series obtained from a temporal yo-yo CTD study, in isopycnal components, over one of the most active points of the submarine volcano have been analyzed in order to investigate the behavior of the system. Signal processing of the thermal time series highlights a strong cyclic temperature period of 125-150 min at 99.9% confidence, due to characteristic time-scales revealed in the periodogram. These long cycles might reflect dynamics occurring within the shallow magma supply system below the island of El Hierro.

  17. Time lag between deformation and seismicity along monogenetic volcanic unrest periods: The case of El Hierro Island (Canary Islands)

    NASA Astrophysics Data System (ADS)

    Lamolda, Héctor; Felpeto, Alicia; Bethencourt, Abelardo

    2017-07-01

    Between 2011 and 2014 there were at least seven episodes of magmatic intrusion in El Hierro Island, but only the first one led to a submarine eruption in 2011-2012. In order to study the relationship between GPS deformation and seismicity during these episodes, we compare the temporal evolution of the deformation with the cumulative seismic energy released. In some of the episodes both deformation and seismicity evolve in a very similar way, but in others a time lag appears between them, in which the deformation precedes the seismicity. Furthermore, a linear correlation between decimal logarithm of intruded magma volume and decimal logarithm of total seismic energy released along the different episodes has been observed. Therefore, if a future magmatic intrusion in El Hierro Island follows this behavior with a proper time lag, we could have an a priori estimate on the order of magnitude the seismic energy released would reach.

  18. On the detection of thermohygrometric differences of Juniperus turbinata habitat between north and south faces in the island of El Hierro (Canary Islands)

    NASA Astrophysics Data System (ADS)

    Salva-Catarineu, Montserrat; Salvador-Franch, Ferran; Lopez-Bustins, Joan A.; Padrón-Padrón, Pedro A.; Cortés-Lucas, Amparo

    2016-04-01

    The current extent of Juniperus turbinata in the island of El Hierro is very small due to heavy exploitation for centuries. The recovery of its natural habitat has such a high environmental and scenic interest since this is a protected species in Europe. The study of the environmental factors that help or limit its recovery is indispensable. Our research project (JUNITUR) studied the populations of juniper woodlands in El Hierro from different environments. These environments are mainly determined by their altitude and exposure to north-easterly trade winds. The main objective of this study was to compare the thermohygrometric conditions of three juniper woodlands: La Dehesa (north-west face at 528 m a.s.l.), El Julan (south face at 996 m a.s.l.) and Sabinosa (north face at 258 m a.s.l.). They are located at different altitude and orientation in El Hierro and present different recovery rates. We used air sensor data loggers fixed to tree branches for recording hourly temperature and humidity data in the three study areas. We analysed daily data of three annual cycles (from September 2012 to August 2015). Similar thermohygrometric annual cycles among the three study areas were observed. We detected the largest differences in winter temperature and summer humidity between the north (to windward) (Sabinosa and La Dehesa) and south (to leeward) (El Julan) faces of the island. The juniper woodland with a highest recovery rate (El Julan) showed the most extreme temperature conditions in both winter and summer seasons. The results of this project might contribute to the knowledge of the juniper bioclimatology in El Hierro, where there is the biggest population of Juniperus turbinata throughout the Canary Islands.

  19. Repeated magmatic intrusions at El Hierro Island following the 2011-2012 submarine eruption

    NASA Astrophysics Data System (ADS)

    Benito-Saz, Maria A.; Parks, Michelle M.; Sigmundsson, Freysteinn; Hooper, Andrew; García-Cañada, Laura

    2017-09-01

    After more than 200 years of quiescence, in July 2011 an intense seismic swarm was detected beneath the center of El Hierro Island (Canary Islands), culminating on 10 October 2011 in a submarine eruption, 2 km off the southern coast. Although the eruption officially ended on 5 March 2012, magmatic activity continued in the area. From June 2012 to March 2014, six earthquake swarms, indicative of magmatic intrusions, were detected underneath the island. We have studied these post-eruption intrusive events using GPS and InSAR techniques to characterize the ground surface deformation produced by each of these intrusions, and to determine the optimal source parameters (geometry, location, depth, volume change). Source inversions provide insight into the depth of the intrusions ( 11-16 km) and the volume change associated with each of them (between 0.02 and 0.13 km3). During this period, > 20 cm of uplift was detected in the central-western part of the island, corresponding to approximately 0.32-0.38 km3 of magma intruded beneath the volcano. We suggest that these intrusions result from deep magma migrating from the mantle, trapped at the mantle/lower crust discontinuity in the form of sill-like bodies. This study, using joint inversion of GPS and InSAR data in a post-eruption period, provides important insight into the characteristics of the magmatic plumbing system of El Hierro, an oceanic intraplate volcanic island.

  20. Eighteen years of geochemical monitoring at the oceanic active volcanic island of El Hierro (Canary Islands, Spain)

    NASA Astrophysics Data System (ADS)

    Asensio-Ramos, María; Alonso, Mar; Sharp, Emerson; Woods, Hannah; Barrancos, José; Pérez, Nemesio M.

    2016-04-01

    We report herein the latest results of a diffuse CO2 efflux survey at El Hierro volcanic system carried out during the summer period of 2015 to constrain the total CO2 output from the studied area a during post-eruptive period. El Hierro Island (278 km2) is the youngest and the SW-most of the Canary Islands. On July 16, 2011, a seismic-volcanic crisis started with the occurrence of more than 11,900 seismic events and significant deformation along the island. On October 10, 2011, the dominant character of seismicity changed dramatically from discrete earthquakes to continuous tremor, a clear indication that magma was rapidly approaching the surface immediately before the onset of the eruption, October 12. Eruption was declared over on 5 March, 2012. In order to monitor the volcanic activity of El Hierro Island, from 1998 to 2015 diffuse CO2 emission studies have been performed at El Hierro volcanic system in a yearly basis (˜600 observation sites) according to the accumulation chamber method. Spatial distribution maps were constructed following the sequential Gaussian simulation (sGs) procedure. To quantify the total CO2 emission from the studied area, 100 simulations for each survey have been performed. During the eruption period, soil CO2 efflux values range from non-detectable (˜0.5 g m-2 d-1) up to 457 g m-2 d-1, reaching in November 27, 2011, the maximum CO2 output estimated value of all time series, 2,398 t d-1, just before the episodes of maximum degassing observed as vigorous bubbling at the sea surface and an increment in the amplitude of the tremor signal. During the 2015 survey, soil CO2 efflux values ranged from non-detectable up to 41 g m-2 d-1. The spatial distribution of diffuse CO2 emission values seemed to be controlled by the main volcano structural features of the island. The total diffuse CO2 output released to atmosphere was estimated at 575 ± 24 t d-1, value slightly higher that the background CO2 emission estimated at 422 t d-1 (Melián et

  1. Origin of three-armed rifts in volcanic islands: the case of El Hierro (Canary Islands)

    NASA Astrophysics Data System (ADS)

    Galindo Jiménez, Inés; Becerril Carretero, Laura; Martí Molist, Joan; Gudmundsson, Agust

    2015-04-01

    Rifts zones in volcanic oceanic islands are common structures that have been explained through several theories/models. However, despite all these models it is as yet unclear whether it is the intense intrusive activity or the sector collapses that actually control the structural evolution and geometry of oceanic-island rift zones. Here we provide a new hypothesis to explain the origin and characteristics of the feeding system of oceanic-island rift zones based on the analysis of more than 1700 surface, subsurface (water galleries), and submarine structural data from El Hierro (Canary Islands). El Hierro's geological structure is primarily controlled by a three-armed rift-zone, the arms striking NE, WSW and S. Between the rift axes there are three valleys formed during huge landslides: El Golfo, El Julan, and Las Playas. Our results show: (1) a predominant NE-SW strike of structural elements, which coincides with the main regional trend of the Canary Archipelago as a whole; (2) a clear radial strike distribution of structural elements for the whole volcanic edifice (including submarine flanks) with respect to the centre of the island; (3) that the rift zones are mainly subaerial structures and do not propagate through the submarine edifice; (4) that it is only in the NE rift that structures have a general strike similar to that of the rift as a whole, and; (5) that in the W and S rifts there is not clear main direction, showing the structural elements in the W rift a fan distribution coinciding with the general radial pattern in the island as a whole. Based on these data, we suggest that the radial-striking structures reflect comparatively uniform stress fields that operated during the constructive episodes, mainly conditioned by the combination of overburden pressure, gravitational spreading, and magma-induced stresses. By contrast, in the shallower parts of the edifice, that is, the NE-SW, N-S and WNW-ESE-striking structures, reflect local stress fields related

  2. Lithospheric magma dynamics beneath the El Hierro Volcano, Canary Islands: insights from fluid inclusions

    NASA Astrophysics Data System (ADS)

    Oglialoro, E.; Frezzotti, M. L.; Ferrando, S.; Tiraboschi, C.; Principe, C.; Groppelli, G.; Villa, I. M.

    2017-10-01

    At active volcanoes, petrological studies have been proven to be a reliable approach in defining the depth conditions of magma transport and storage in both the mantle and the crust. Based on fluid inclusion and mineral geothermobarometry in mantle xenoliths, we propose a model for the magma plumbing system of the Island of El Hierro (Canary Islands). The peridotites studied here were entrained in a lava flow exposed in the El Yulan Valley. These lavas are part of the rift volcanism that occurred on El Hierro at approximately 40-30 ka. The peridotites are spinel lherzolites, harzburgites, and dunites which equilibrated in the shallow mantle at pressures between 1.5 and 2 GPa and at temperatures between 800 and 950 °C (low-temperature peridotites; LT), as well as at higher equilibration temperatures of 900 to 1100 °C (high-temperature peridotites; HT). Microthermometry and Raman analyses of fluid inclusions reveal trapping of two distinct fluid phases: early type I metasomatic CO2-N2 fluids ( X N2 = 0.01-0.18; fluid density (d) = 1.19 g/cm3), coexisting with silicate-carbonate melts in LT peridotites, and late type II pure CO2 fluids in both LT (d = 1.11-1.00 and 0.75-0.65 g/cm3) and HT ( d = 1.04-1.11 and 0.75-0.65 g/cm3) peridotites. While type I fluids represent metasomatic phases in the deep oceanic lithosphere (at depths of 60-65 km) before the onset of magmatic activity, type II CO2 fluids testify to two fluid trapping episodes during the ascent of xenoliths in their host mafic magmas. Identification of magma accumulation zones through interpretation of type II CO2 fluid inclusions and mineral geothermobarometry indicate the presence of a vertically stacked system of interconnected small magma reservoirs in the shallow lithospheric mantle between a depth of 22 and 36 km (or 0.67 to 1 GPa). This magma accumulation region fed a short-lived magma storage region located in the lower oceanic crust at a depth of 10-12 km (or 0.26-0.34 GPa). Following our model

  3. Significant discharge of CO2 from hydrothermalism associated with the submarine volcano of El Hierro Island

    NASA Astrophysics Data System (ADS)

    Santana-Casiano, J. M.; Fraile-Nuez, E.; González-Dávila, M.; Baker, E. T.; Resing, J. A.; Walker, S. L.

    2016-05-01

    The residual hydrothermalism associated with submarine volcanoes, following an eruption event, plays an important role in the supply of CO2 to the ocean. The emitted CO2 increases the acidity of seawater. The submarine volcano of El Hierro, in its degasification stage, provided an excellent opportunity to study the effect of volcanic CO2 on the seawater carbonate system, the global carbon flux, and local ocean acidification. A detailed survey of the volcanic edifice was carried out using seven CTD-pH-ORP tow-yo studies, localizing the redox and acidic changes, which were used to obtain surface maps of anomalies. In order to investigate the temporal variability of the system, two CTD-pH-ORP yo-yo studies were conducted that included discrete sampling for carbonate system parameters. Meridional tow-yos were used to calculate the amount of volcanic CO2 added to the water column for each surveyed section. The inputs of CO2 along multiple sections combined with measurements of oceanic currents produced an estimated volcanic CO2 flux = 6.0 105 ± 1.1 105 kg d-1 which is ~0.1% of global volcanic CO2 flux. Finally, the CO2 emitted by El Hierro increases the acidity above the volcano by ~20%.

  4. Significant discharge of CO2 from hydrothermalism associated with the submarine volcano of El Hierro Island.

    PubMed

    Santana-Casiano, J M; Fraile-Nuez, E; González-Dávila, M; Baker, E T; Resing, J A; Walker, S L

    2016-05-09

    The residual hydrothermalism associated with submarine volcanoes, following an eruption event, plays an important role in the supply of CO2 to the ocean. The emitted CO2 increases the acidity of seawater. The submarine volcano of El Hierro, in its degasification stage, provided an excellent opportunity to study the effect of volcanic CO2 on the seawater carbonate system, the global carbon flux, and local ocean acidification. A detailed survey of the volcanic edifice was carried out using seven CTD-pH-ORP tow-yo studies, localizing the redox and acidic changes, which were used to obtain surface maps of anomalies. In order to investigate the temporal variability of the system, two CTD-pH-ORP yo-yo studies were conducted that included discrete sampling for carbonate system parameters. Meridional tow-yos were used to calculate the amount of volcanic CO2 added to the water column for each surveyed section. The inputs of CO2 along multiple sections combined with measurements of oceanic currents produced an estimated volcanic CO2 flux = 6.0 10(5) ± 1.1 10(5 )kg d(-1) which is ~0.1% of global volcanic CO2 flux. Finally, the CO2 emitted by El Hierro increases the acidity above the volcano by ~20%.

  5. Significant discharge of CO2 from hydrothermalism associated with the submarine volcano of El Hierro Island

    PubMed Central

    Santana-Casiano, J. M.; Fraile-Nuez, E.; González-Dávila, M.; Baker, E. T.; Resing, J. A.; Walker, S. L.

    2016-01-01

    The residual hydrothermalism associated with submarine volcanoes, following an eruption event, plays an important role in the supply of CO2 to the ocean. The emitted CO2 increases the acidity of seawater. The submarine volcano of El Hierro, in its degasification stage, provided an excellent opportunity to study the effect of volcanic CO2 on the seawater carbonate system, the global carbon flux, and local ocean acidification. A detailed survey of the volcanic edifice was carried out using seven CTD-pH-ORP tow-yo studies, localizing the redox and acidic changes, which were used to obtain surface maps of anomalies. In order to investigate the temporal variability of the system, two CTD-pH-ORP yo-yo studies were conducted that included discrete sampling for carbonate system parameters. Meridional tow-yos were used to calculate the amount of volcanic CO2 added to the water column for each surveyed section. The inputs of CO2 along multiple sections combined with measurements of oceanic currents produced an estimated volcanic CO2 flux = 6.0 105 ± 1.1 105 kg d−1 which is ~0.1% of global volcanic CO2 flux. Finally, the CO2 emitted by El Hierro increases the acidity above the volcano by ~20%. PMID:27157062

  6. Palaeomagnetic constraints on the age of Lomo Negro volcanic eruption (El Hierro, Canary Islands)

    NASA Astrophysics Data System (ADS)

    Villasante-Marcos, Víctor; Pavón-Carrasco, Francisco Javier

    2014-12-01

    A palaeomagnetic study has been carried out in 29 cores drilled at six different sites from the volcanic products of Lomo Negro eruption (El Hierro, Canary Islands, Spain). Systematic thermal and alternating field demagnetization of the samples' natural remanent magnetization revealed a northward, stable palaeomagnetic direction similar in all the samples. Rock magnetic experiments indicate that this palaeomagnetic component is carried by a mixture of high-Ti and low-Ti titanomagnetite crystals typical of basaltic lithologies that have experienced a significant degree of oxyexsolution during subaerial cooling. The well constrained palaeomagnetic direction of Lomo Negro lavas was used to perform a palaeomagnetic dating of the volcanic event, using the SHA.DIF.14k global geomagnetic model restricted for the last 3000 yr. It can be unambiguously concluded that Lomo Negro eruption occurred well before the previously proposed date of 1793 AD, with three different age ranges being statistically possible during the last 3 ka: 115 BC-7 AD, 410-626 AD and 1499-1602 AD. The calibration of a previously published non-calibrated 14C dating suggests a XVI c. date for Lomo Negro eruption. This conclusion leaves open the possibility that the seismic crisis occurred at El Hierro in 1793 AD was related to an intrusive magmatic event that either did not reach the surface or either culminated in an unregistered submarine eruption similar to the one occurred in 2011-2012 at the southern off-shore ridge of the island.

  7. Precursory diffuse CO2 and H2S emission signatures of the 2011-2012 El Hierro submarine eruption, Canary Islands

    NASA Astrophysics Data System (ADS)

    Pérez, Nemesio M.; Padilla, Germán D.; Padrón, Eleazar; Hernández, Pedro A.; Melián, Gladys V.; Barrancos, José; Dionis, Samara; Nolasco, Dácil; Rodríguez, Fátima; Calvo, David; Hernández, Íñigo

    2012-08-01

    On October 12, 2011, a submarine eruption began 2 km off the coast of La Restinga, south of El Hierro Island. CO2 and H2S soil efflux were continuously measured during the period of volcanic unrest by using the accumulation chamber method at two different geochemical stations, HIE01 and HIE07. Recorded CO2 and H2S effluxes showed precursory signals that preceded the submarine eruption. Beginning in late August, the CO2 efflux time series started increasing at a relatively constant rate over one month, reaching a maximum of 19 gm-2d-1 one week before the onset of the submarine volcanic eruption. The H2S efflux time series at HIE07 showed a pulse in H2S emission just one day before the initiation of the submarine eruption, reaching peak values of 42 mg m-2 d-1, 10 times the average H2S efflux recorded during the observation period. Since CO2 and H2S effluxes are strongly influenced by external factors, we applied a multiple regression analysis to remove their contribution. A statistical analysis showed that the long-term trend of the filtered data is well correlated with the seismic energy. We find that these geochemical stations are important monitoring sites for evaluating the volcanic activity of El Hierro and that they demonstrate the potential of applying continuous monitoring of soil CO2 and H2S efflux to improve and optimize the detection of early warning signals of future volcanic unrest episodes at El Hierro. Continuous diffuse degassing studies would likely prove useful for monitoring other volcanoes during unrest episodes.

  8. Mode switching in volcanic seismicity: El Hierro 2011-2013

    NASA Astrophysics Data System (ADS)

    Roberts, Nick S.; Bell, Andrew F.; Main, Ian G.

    2016-05-01

    The Gutenberg-Richter b value is commonly used in volcanic eruption forecasting to infer material or mechanical properties from earthquake distributions. Such studies typically analyze discrete time windows or phases, but the choice of such windows is subjective and can introduce significant bias. Here we minimize this sample bias by iteratively sampling catalogs with randomly chosen windows and then stack the resulting probability density functions for the estimated b>˜ value to determine a net probability density function. We examine data from the El Hierro seismic catalog during a period of unrest in 2011-2013 and demonstrate clear multimodal behavior. Individual modes are relatively stable in time, but the most probable b>˜ value intermittently switches between modes, one of which is similar to that of tectonic seismicity. Multimodality is primarily associated with intermittent activation and cessation of activity in different parts of the volcanic system rather than with respect to any systematic inferred underlying process.

  9. Floating stones off El Hierro, Canary Islands: xenoliths of pre-island sedimentary origin in the early products of the October 2011 eruption

    NASA Astrophysics Data System (ADS)

    Troll, V. R.; Klügel, A.; Longpré, M.-A.; Burchardt, S.; Deegan, F. M.; Carracedo, J. C.; Wiesmaier, S.; Kueppers, U.; Dahren, B.; Blythe, L. S.; Hansteen, T. H.; Freda, C.; Budd, D. A.; Jolis, E. M.; Jonsson, E.; Meade, F. C.; Harris, C.; Berg, S. E.; Mancini, L.; Polacci, M.; Pedroza, K.

    2012-03-01

    A submarine eruption started off the south coast of El Hierro, Canary Islands, on 10 October 2011 and continues at the time of this writing (February 2012). In the first days of the event, peculiar eruption products were found floating on the sea surface, drifting for long distances from the eruption site. These specimens, which have in the meantime been termed "restingolites" (after the close-by village of La Restinga), appeared as black volcanic "bombs" that exhibit cores of white and porous pumice-like material. Since their brief appearance, the nature and origin of these "floating stones" has been vigorously debated among researchers, with important implications for the interpretation of the hazard potential of the ongoing eruption. The "restingolites" have been proposed to be either (i) juvenile high-silica magma (e.g. rhyolite), (ii) remelted magmatic material (trachyte), (iii) altered volcanic rock, or (iv) reheated hyaloclastites or zeolite from the submarine slopes of El Hierro. Here, we provide evidence that supports yet a different conclusion. We have analysed the textures and compositions of representative "restingolites" and compared the results to previous work on similar rocks found in the Canary Islands. Based on their high-silica content, the lack of igneous trace element signatures, the presence of remnant quartz crystals, jasper fragments and carbonate as well as wollastonite (derived from thermal overprint of carbonate) and their relatively high oxygen isotope values, we conclude that "restingolites" are in fact xenoliths from pre-island sedimentary layers that were picked up and heated by the ascending magma, causing them to partially melt and vesiculate. As they are closely resembling pumice in appearance, but are xenolithic in origin, we refer to these rocks as "xeno-pumice". The El Hierro xeno-pumices hence represent messengers from depth that help us to understand the interaction between ascending magma and crustal lithologies beneath the

  10. Magma displacements under insular volcanic fields, applications to eruption forecasting: El Hierro, Canary Islands, 2011-2013

    NASA Astrophysics Data System (ADS)

    García, A.; Fernández-Ros, A.; Berrocoso, M.; Marrero, J. M.; Prates, G.; De la Cruz-Reyna, S.; Ortiz, R.

    2014-04-01

    Significant deformations, followed by increased seismicity detected since 2011 July at El Hierro, Canary Islands, Spain, prompted the deployment of additional monitoring equipment. The climax of this unrest was a submarine eruption first detected on 2011 October 10, and located at about 2 km SW of La Restinga, southernmost village of El Hierro Island. The eruption ceased on 2012 March 5, after the volcanic tremor signals persistently weakened through 2012 February. However, the seismic activity did not end with the eruption, as several other seismic crises followed. The seismic episodes presented a characteristic pattern: over a few days the number and magnitude of seismic event increased persistently, culminating in seismic events severe enough to be felt all over the island. Those crises occurred in 2011 November, 2012 June and September, 2012 December to 2013 January and in 2013 March-April. In all cases the seismic unrest was preceded by significant deformations measured on the island's surface that continued during the whole episode. Analysis of the available GPS and seismic data suggests that several magma displacement processes occurred at depth from the beginning of the unrest. The first main magma movement or `injection' culminated with the 2011 October submarine eruption. A model combining the geometry of the magma injection process and the variations in seismic energy release has allowed successful forecasting of the new-vent opening.

  11. Observations of coupled seismicity and ground deformation at El Hierro Island (2011-2014)

    NASA Astrophysics Data System (ADS)

    Gonzalez, P. J.

    2015-12-01

    New insights into the magma storage and evolution at oceanic island volcanoes are now being achieved using remotely sensed space geodetic techniques, namely satellite radar interferometry. Differential radar interferometry is a technique tracking, at high spatial resolution, changes in the travel-time (distance) from the satellites to the ground surface, having wide applications in Earth sciences. Volcanic activity usually is accompanied by surface ground deformation. In many instances, modelling of surface deformation has the great advantage to estimate the magma volume change, a particularly interesting parameter prior to eruptions. Jointly interpreted with petrology, degassing and seismicity, it helps to understand the crustal magmatic systems as a whole. Current (and near-future) radar satellite missions will reduce the revisit time over global sub-aerial volcanoes to a sub-weekly basis, which will increase the potential for its operational use. Time series and filtering processing techniques of such streaming data would allow to track subsurface magma migration with high precision, and frequently update over vast areas (volcanic arcs, large caldera systems, etc.). As an example for the future potential monitoring scenario, we analyze multiple satellite radar data over El Hierro Island (Canary Islands, Spain) to measure and model surface ground deformation. El Hierro has been active for more than 3 years (2011 to 2014). Initial phases of the unrest culminated in a submarine eruption (late 2011 - early 2012). However, after the submarine eruption ended, its magmatic system still active and affected by pseudo-regular energetic seismic swarms, accompanied by surface deformation without resumed eruptions. Such example is a great opportunity to understand the crustal magmatic systems in low magma supply-rate oceanic island volcanoes. This new approach to measure surface deformation processes is yielding an ever richer level of information from volcanology to

  12. Multiparametric statistical investigation of seismicity occurred at El Hierro (Canary Islands) from 2011 to 2014

    NASA Astrophysics Data System (ADS)

    Telesca, Luciano; Lovallo, Michele; Lopez, Carmen; Marti Molist, Joan

    2016-03-01

    A detailed statistical investigation of the seismicity occurred at El Hierro volcano (Canary Islands) from 2011 to 2014 has been performed by analysing the time variation of four parameters: the Gutenberg-Richter b-value, the local coefficient of variation, the scaling exponent of the magnitude distribution and the main periodicity of the earthquake sequence calculated by using the Schuster's test. These four parameters are good descriptors of the time and magnitude distributions of the seismic sequence, and their variation indicate dynamical changes in the volcanic system. These variations can be attributed to the causes and types of seismicity, thus allowing to distinguish between different host-rock fracturing processes caused by intrusions of magma at different depths and overpressures. The statistical patterns observed among the studied unrest episodes and between them and the eruptive episode of 2011-2012 indicate that the response of the host rock to the deformation imposed by magma intrusion did not differ significantly from one episode to the other, thus suggesting that no significant local stress changes induced by magma intrusion occurred when comparing between all them. Therefore, despite the studied unrest episodes were caused by intrusions of magma at different depths and locations below El Hierro island, the mechanical response of the lithosphere was similar in all cases. This suggests that the reason why the first unrest culminated in an eruption while the other did not, may be related to the role of the regional/local tectonics acting at that moment, rather than to the forceful of magma intrusion.

  13. The submarine volcano eruption at the island of El Hierro: physical-chemical perturbation and biological response

    NASA Astrophysics Data System (ADS)

    Fraile-Nuez, E.; Santana-Casiano, J.; Gonzalez-Davila, M.

    2013-12-01

    On October 10 2011 an underwater eruption gave rise to a novel shallow submarine volcano south of the island of El Hierro, Canary Islands, Spain. During the eruption large quantities of mantle-derived gases, solutes and heat were released into the surrounding waters. In order to monitor the impact of the eruption on the marine ecosystem, periodic multidisciplinary cruises were carried out. Here, we present an initial report of the extreme physical-chemical perturbations caused by this event, comprising thermal changes, water acidification, deoxygenation and metal-enrichment, which resulted in significant alterations to the activity and composition of local plankton communities. Our findings highlight the potential role of this eruptive process as a natural ecosystem-scale experiment for the study of extreme effects of global change stressors on marine environments. (A) Natural color composite from the MEdium Resolution Imaging Spectrometer (MERIS) instrument aboard ENVISAT Satellite (European Space Agency), (November 9, 2011 at 14:45 UTC). Remote sensing data have been used to monitor the evolution of the volcanic emissions, playing a fundamental role during field cruises in guiding the Spanish government oceanographic vessel to the appropriate sampling areas. The inset map shows the position of Canary Islands west of Africa and the study area (solid white box). (B) Location of the stations carried out from November 2011 to February 2012 at El Hierro. Black lines denote transects A-B and C-D.

  14. Environmental monitoring of El Hierro Island submarine volcano, by combining low and high resolution satellite imagery

    NASA Astrophysics Data System (ADS)

    Eugenio, F.; Martin, J.; Marcello, J.; Fraile-Nuez, E.

    2014-06-01

    El Hierro Island, located at the Canary Islands Archipelago in the Atlantic coast of North Africa, has been rocked by thousands of tremors and earthquakes since July 2011. Finally, an underwater volcanic eruption started 300 m below sea level on October 10, 2011. Since then, regular multidisciplinary monitoring has been carried out in order to quantify the environmental impacts caused by the submarine eruption. Thanks to this natural tracer release, multisensorial satellite imagery obtained from MODIS and MERIS sensors have been processed to monitor the volcano activity and to provide information on the concentration of biological, chemical and physical marine parameters. Specifically, low resolution satellite estimations of optimal diffuse attenuation coefficient (Kd) and chlorophyll-a (Chl-a) concentration under these abnormal conditions have been assessed. These remote sensing data have played a fundamental role during field campaigns guiding the oceanographic vessel to the appropriate sampling areas. In addition, to analyze El Hierro submarine volcano area, WorldView-2 high resolution satellite spectral bands were atmospherically and deglinted processed prior to obtain a high-resolution optimal diffuse attenuation coefficient model. This novel algorithm was developed using a matchup data set with MERIS and MODIS data, in situ transmittances measurements and a seawater radiative transfer model. Multisensor and multitemporal imagery processed from satellite remote sensing sensors have demonstrated to be a powerful tool for monitoring the submarine volcanic activities, such as discolored seawater, floating material and volcanic plume, having shown the capabilities to improve the understanding of submarine volcanic processes.

  15. Short-term volcano-tectonic earthquake forecasts based on a moving mean recurrence time algorithm: the El Hierro seismo-volcanic crisis experience

    NASA Astrophysics Data System (ADS)

    García, Alicia; De la Cruz-Reyna, Servando; Marrero, José M.; Ortiz, Ramón

    2016-05-01

    Under certain conditions, volcano-tectonic (VT) earthquakes may pose significant hazards to people living in or near active volcanic regions, especially on volcanic islands; however, hazard arising from VT activity caused by localized volcanic sources is rarely addressed in the literature. The evolution of VT earthquakes resulting from a magmatic intrusion shows some orderly behaviour that may allow the occurrence and magnitude of major events to be forecast. Thus governmental decision makers can be supplied with warnings of the increased probability of larger-magnitude earthquakes on the short-term timescale. We present here a methodology for forecasting the occurrence of large-magnitude VT events during volcanic crises; it is based on a mean recurrence time (MRT) algorithm that translates the Gutenberg-Richter distribution parameter fluctuations into time windows of increased probability of a major VT earthquake. The MRT forecasting algorithm was developed after observing a repetitive pattern in the seismic swarm episodes occurring between July and November 2011 at El Hierro (Canary Islands). From then on, this methodology has been applied to the consecutive seismic crises registered at El Hierro, achieving a high success rate in the real-time forecasting, within 10-day time windows, of volcano-tectonic earthquakes.

  16. Seismic hydraulic fracture migration originated by successive deep magma pulses: The 2011-2013 seismic series associated to the volcanic activity of El Hierro Island

    NASA Astrophysics Data System (ADS)

    Díaz-Moreno, A.; Ibáñez, J. M.; De Angelis, S.; García-Yeguas, A.; Prudencio, J.; Morales, J.; Tuvè, T.; García, L.

    2015-11-01

    In this manuscript we present a new interpretation of the seismic series that accompanied eruptive activity off the coast of El Hierro, Canary Islands, during 2011-2013. We estimated temporal variations of the Gutenberg-Richter b value throughout the period of analysis, and performed high-precision relocations of the preeruptive and syneruptive seismicity using a realistic 3-D velocity model. Our results suggest that eruptive activity and the accompanying seismicity were caused by repeated injections of magma from the mantle into the lower crust. These magma pulses occurred within a small and well-defined volume resulting in the emplacement of fresh magma along the crust-mantle boundary underneath El Hierro. We analyzed the distribution of earthquake hypocenters in time and space in order to assess seismic diffusivity in the lower crust. Our results suggest that very high earthquake rates underneath El Hierro represent the response of a stable lower crust to stress perturbations with pulsatory character, linked to the injection of magma from the mantle. Magma input from depth caused large stress perturbations to propagate into the lower crust generating energetic seismic swarms. The absence of any preferential alignment in the spatial pattern of seismicity reinforces our hypothesis that stress perturbation and related seismicity, had diffusive character. We conclude that the temporal and spatial evolution of seismicity was neither tracking the path of magma migration nor it defines the boundaries of magma storage volumes such as a midcrustal sill. Our conceptual model considers pulsatory magma injection from the upper mantle and its propagation along the Moho. We suggest, within this framework, that the spatial and temporal distributions of earthquake hypocenters reflect hydraulic fracturing processes associated with stress propagation due to magma movement.

  17. Submarine seismic monitoring of El Hierro volcanic eruption with a 3C-geophone string: applying new acquisition and data processing techniques to volcano monitoring

    NASA Astrophysics Data System (ADS)

    Jurado, Maria Jose; Ripepe, Maurizio; Lopez, Carmen; Blanco, Maria Jose; Crespo, Jose

    2015-04-01

    A submarine volcanic eruption took place near the southernmost emerged land of the El Hierro Island (Canary Islands, Spain), from October 2011 to February 2012. The Instituto Geografico Nacional (IGN) seismic stations network evidenced seismic unrest since July 2011 and was a reference also to follow the evolution of the seismic activity associated with the volcanic eruption. Right after the eruption onset, in October 2011 a geophone string was deployed by the CSIC-IGN to monitor seismic activity. Monitoring with the seismic array continued till May 2012. The array was installed less than 2 km away from the new vol¬cano, next to La Restinga village shore in the harbor from 6 to 12m deep into the water. Our purpose was to record seismic activity related to the volcanic activity, continuously and with special interest on high frequency events. The seismic array was endowed with 8, high frequency, 3 component, 250 Hz, geophone cable string with a separation of 6 m between them. Each geophone consists on a 3-component module based on 3 orthogonal independent sensors that measures ground velocity. Some of the geophones were placed directly on the seabed, some were buried. Due to different factors, as the irregular characteristics of the seafloor. The data was recorded on the surface with a seismometer and stored on a laptop computer. We show how acoustic data collected underwater show a great correlation with the seismic data recorded on land. Finally we compare our data analysis results with the observed sea surface activity (ash and lava emission and degassing). This evidence is disclosing new and innovative tecniques on monitoring submarine volcanic activity. Reference Instituto Geográfico Nacional (IGN), "Serie El Hierro." Internet: http://www.ign.es/ign/resources /volcanologia/HIERRO.html [May, 17. 2013

  18. Spatial and temporal variations of diffuse CO2 degassing at El Hierro volcanic system: Relation to the 2011-2012 submarine eruption

    NASA Astrophysics Data System (ADS)

    Melián, Gladys; Hernández, Pedro A.; Padrón, Eleazar; Pérez, Nemesio M.; Barrancos, José; Padilla, Germán.; Dionis, Samara; Rodríguez, Fátima; Calvo, David; Nolasco, Dacil

    2014-09-01

    We report herein the results of extensive diffuse CO2 emission surveys performed on El Hierro Island in the period 1998-2012. More than 17,000 measurements of the diffuse CO2 efflux were carried out, most of them during the volcanic unrest period that started in July 2011. Two significant precursory signals based on geochemical and geodetical studies suggest that a magma intrusion processes might have started before 2011 in El Hierro Island. During the preeruptive and eruptive periods, the time series of the diffuse CO2 emission released by the whole island experienced two significant increases. The first started almost 2 weeks before the onset of the submarine eruption, reflecting a clear geochemical anomaly in CO2 emission, most likely due to increasing release of deep-seated magmatic gases to the surface. The second one, between 24 October and 27 November 2011, started before the most energetic seismic events of the volcanic-seismic unrest. The data presented here demonstrate that combined continuous monitoring studies and discrete surveys of diffuse CO2 emission provide important information to optimize the early warning system in volcano monitoring programs and to monitor the evolution of an ongoing volcanic eruption, even though it is a submarine eruption.

  19. Floating sandstones off El Hierro (Canary Islands, Spain): the peculiar case of the October 2011 eruption

    NASA Astrophysics Data System (ADS)

    Troll, V. R.; Klügel, A.; Longpré, M.-A.; Burchardt, S.; Deegan, F. M.; Carracedo, J. C.; Wiesmaier, S.; Kueppers, U.; Dahren, B.; Blythe, L. S.; Hansteen, T.; Freda, C.; Budd, D. A.; Jolis, E. M.; Jonsson, E.; Meade, F.; Berg, S.; Mancini, L.; Polacci, M.

    2011-12-01

    The eruption that started off the south coast of El Hierro, Canary Islands, in October 2011 has emitted intriguing eruption products found floating in the sea. These specimens appeared as floating volcanic "bombs" that have in the meantime been termed "restingolites" (after the close-by village of La Restinga) and exhibit cores of white and porous pumice-like material. Currently the nature and origin of these "floating stones" is vigorously debated among researchers, with important implications for the interpretation of the hazard potential of the ongoing eruption. The "restingolites" have been proposed to be either (i) juvenile high-silica magma (e.g. rhyolite), (ii) remelted magmatic material (trachyte), (iii) altered volcanic rock, or (iv) reheated hyaloclastites or zeolite from the submarine slopes of El Hierro. Here, we provide evidence that supports yet a different conclusion. We have collected and analysed the structure and composition of samples and compared the results to previous work on similar rocks found in the archipelago. Based on their high silica content, the lack of igneous trace element signatures, and the presence of remnant quartz crystals, jasper fragments and carbonate relicts, we conclude that "restingolites" are in fact xenoliths from pre-island sedimentary rocks that were picked up and heated by the ascending magma causing them to partially melt and vesiculate. They hence represent messengers from depth that help us to understand the interaction between ascending magma and crustal lithologies in the Canary Islands as well as in similar Atlantic islands that rest on sediment/covered ocean crust (e.g. Cape Verdes, Azores). The occurrence of these "restingolites" does therefore not indicate the presence of an explosive high-silica magma that is involved in the ongoing eruption.

  20. On the relation between crustal deformation and seismicity during the 2012-2014 magmatic intrusions in El Hierro island.

    NASA Astrophysics Data System (ADS)

    Domínguez Cerdeña, Itahiza; García-Cañada, Laura; Ángeles Benito Saz, María; Del Fresno, Carmen

    2017-04-01

    The last volcanic eruption in the Canary Islands took place in 2011 less than 2 km offshore El Hierro island, after 3 months of measuring surface deformation (up to 5 cm) and locating more than 10 000 earthquakes. In the two years following the end of the submarine eruption on 5 March 2012, six deep magmatic intrusions were recorded beneath the island. Despite the short time duration of these intrusions, these events have been more energetic that the 2011 pre-eruptive intrusive event but none of them ended in a new eruption. These post-eruptive reactivations are some of the few examples in the world of well monitored magmatic intrusions related with monogenetic volcanism. In order to understand these processes we have analyzed the geodetic and seismic data with different techniques. First, we did a joint hypocentral relocation of the six seismic swarms, including more than 6 300 events, to analyze the relative distribution of the earthquakes from different intrusions. The uncertainties of the earthquakes relocations was reduced to an average value of 300 m. New earthquakes' distribution shows the alignments of the different intrusions and a temporal migration of the events to larger depths. Moreover, we show the results of the ground deformation using GPS data from the network installed on the island (for each of the six intrusive events) and their inversion considering spherical models. In most of the intrusions the optimal source model was shallower and southern than the corresponding seismicity hypocenters. The intruded magma volume ranges from 0.02 to 0.13 km3. Finally, we also computed the b value from the Gutenberg Richter equation by means of a bootstrap method. The spatial and temporal evolution of the b value for the seismicity show a clear correlation with the temporal evolution of the crustal deformation. The six magma intrusions can be grouped, depending on their location, in three pairs each one associated with each of the three active rifts of El

  1. Magnetic imaging of the feeding system of oceanic volcanic islands: El Hierro (Canary Islands)

    NASA Astrophysics Data System (ADS)

    Blanco-Montenegro, Isabel; Nicolosi, Iacopo; Pignatelli, Alessandro; Chiappini, Massimo

    2008-04-01

    El Hierro is the youngest of the Canary Islands, a volcanic archipelago in the central Atlantic, near the African coast. The subaerial part of the island shows the characteristic shape of three convergent ridges that has been interpreted as a triple-arm rift system. At least four giant landslides formed wide, horseshoe embayments that separate these ridges. Recent studies based on high-resolution bathymetry, however, showed that the submarine rift structure is much more complex. We analysed an aeromagnetic anomaly data set acquired in 1993 by the Spanish National Geographic Institute in order to obtain a structural model of the island from a magnetic point of view. A digital elevation model of the volcanic edifice was divided into a mesh of prismatic cells, each of them with a top corresponding to the topographic height (or bathymetric depth in the marine area) and a bottom at a constant depth of 4000 m below sea level. A three-dimensional (3-D) inversion algorithm and forward modelling along representative profiles provided us with a magnetization distribution containing valuable information about the inner structure of the island. The magnetic model cast new light on the rift structure of El Hierro. In particular, high magnetization values have been mainly interpreted as intrusive complexes on which rift zones are rooted. Their location confirms the hypothesis of a complex rift structure in the marine area. The inverse magnetization that characterizes the NE submarine rift area implies that this part of the volcanic edifice formed during the Matuyama and, therefore, predates the NW submarine rift zone, which is normally magnetized. The N-S rift zone extending southwards from the island seems to be shifted to the west with respect to the bathymetric high in this area. This result suggests that the original rift zone was located in the area where the highest magnetizations presently occur so that the present morphology may reflect the westward collapse of the

  2. Fracture and damage localization in volcanic edifice rocks from El Hierro, Stromboli and Tenerife.

    PubMed

    Harnett, Claire E; Benson, Philip M; Rowley, Pete; Fazio, Marco

    2018-01-31

    We present elastic wave velocity and strength data from a suite of three volcanic rocks taken from the volcanic edifices of El Hierro and Tenerife (Canary Islands, Spain), and Stromboli (Aeolian Islands, Italy). These rocks span a range of porosity and are taken from volcanoes that suffer from edifice instability. We measure elastic wave velocities at known incident angles to the generated through-going fault as a function of imposed strain, and examine the effect of the damage zone on P-wave velocity. Such data are important as field measurements of elastic wave tomography are key tools for understanding volcanic regions, yet hidden fractures are likely to have a significant effect on elastic wave velocity. We then use elastic wave velocity evolution to calculate concomitant crack density evolution which ranges from 0 to 0.17: highest values were correlated to the damage zone in rocks with the highest initial porosity.

  3. Diffuse H_{2} emission: a useful geochemical tool to monitor the volcanic activity at El Hierro volcano system

    NASA Astrophysics Data System (ADS)

    Pérez, Nemesio M.; Melián, Gladys; González-Santana, Judit; Barrancos, José; Padilla, Germán; Rodríguez, Fátima; Padrón, Eleazar; Hernández, Pedro A.

    2016-04-01

    The occurrence of interfering processes affecting reactive gases as CO2 during its ascent from magmatic bodies or hydrothermal systems toward the surface environment hinders the interpretation of their enrichments in the soil atmosphere and fluxes for volcano monitoring purposes (Marini and Gambardella, 2005). These processes include gas scrubbing by ground-waters and interaction with rocks, decarbonatation processes, biogenic production, etc. Within the rest of the soil gases, particularly interest has been addressed to light and highly mobile gases. They offer important advantages for the detection of vertical permeability structures, because their interaction with the surrounding rocks or fluids during the ascent toward the surface is minimum. H2 is one of the most abundant trace species in volcano-hydrothermal systems and is a key participant in many redox reactions occurring in the hydrothermal reservoir gas (Giggenbach, 1987). Although H2 can be produced in soils by N2-fixing and fertilizing bacteria, soils are considered nowadays as sinks of molecular hydrogen (Smith-Downey et al., 2006). Because of its chemical and physical characteristics, H2 generated within the crust moves rapidly and escapes to the atmosphere. These characteristics make H2 one of the best geochemical indicators of magmatic and geothermal activity at depth. El Hierro is the youngest and the SW-most of the Canary Islands and the scenario of the last volcanic eruption of the archipelago, a submarine eruption that took place 2 km off the southern coast of the island from October 2011 to March 2012. Since at El Hierro Island there are not any surface geothermal manifestations (fumaroles, etc), we have focused our studies on soil degassing surveys. Here we show the results of soil H2 emission surveys that have been carried out regularly since mid-2012. Soil gas samples were collected in ˜600 sites selected based on their accessibility and geological criteria. Soil gases were sampled at ˜40

  4. The 2011 submarine volcanic eruption of El Hierro Island (Canary Islands, Spain)

    NASA Astrophysics Data System (ADS)

    López, C.; Blanco, M. J.

    2012-04-01

    On 10 October 2011 a submarine volcanic eruption began 2 km SW of La Restinga village in the South coast of El Hierro Island (Spain). It became the first submarine eruption reported in 500 years of historical record in the Canary Islands. The eruption took place after three months of intensive seismic activity and ground deformation. The first signal evidencing the eruption was a harmonic tremor signal, located somewhere in the South sector of El Hierro Island and registered in every seismic station on the island. On the following day, the tremoŕs amplitude increased up enough to be felt by the residents of La Restinga. The first visual evidence of the eruption was observed during the afternoon of 12 October, a large light-green coloured area on the sea surface, 2 km to the SW of La Restinga. Three days later, steaming lava fragments were observed floating on the sea, in the area where the vent was supposed to be located. These fragments had a bomb-like shape and their sizes ranged between 10 and 40 cm long. They were bicoloured, a black outer part with a basaltic composition, and a white inner part, highly vesiculated and rich in silica content (>60%). This type of fragments was only observed during the first days of the eruption. Within the next two months further emission episodes have been observed with turbulent water, foam rings and large bubbles on the sea surface. On the 27th of November new lava fragments were observed while floating and degassing on the sea surface. Most of them were "lava balloons" or hollow fragments of lavas, with sizes between 30 and 200 cm, and highly vesiculated outer crust of basaltic-basanitic and sideromelane composition. The emission of these products continues intermitently up to date (January 2012) During the eruption, the GPS monitoring network detected episodes of inflation-deflation and a maximum vertical deformation of 4 cm. The horizontal deformation, which had reached up to 5 cm before the eruption, remains stable. The

  5. Relación masa-radio para estrellas enanas blancas y la interpretación de recientes mediciones hechas por Hipparcos

    NASA Astrophysics Data System (ADS)

    Panei, J. A.; Althaus, L. G.; Benvenuto, O. G.

    Recientes mediciones de la masa y el radio hechas por Hipparcos de las estrellas enanas blancas 40 Eri B y Procyon B (Shipman, H. & Provencal, J. - ApJ. 1998, 494, 759), sugieren un núcleo compuesto de hierro para dichas estrellas, en lugar de carbono y oxígeno como predice la teoría standard de evolución estelar. Para interpretar estas observaciones, presentamos aquí, relaciones masa-radio para configuraciones degeneradas a temperatura finita para distintas composiciones químicas centrales. Para tal fin hemos calculado secuencias evolutivas de enanas blancas utilizando el código de evolución estelar, desarrollado en el Observatorio de La Plata. Dicho código resuelve las ecuaciones de estructura y evolución estelar mediante la técnica de relajación de Henyey, y esta basado en una descripción física muy detallada y actualizada.

  6. Mantle to surface degassing of carbon- and sulphur-rich alkaline magma at El Hierro, Canary Islands

    NASA Astrophysics Data System (ADS)

    Longpré, Marc-Antoine; Stix, John; Klügel, Andreas; Shimizu, Nobumichi

    2017-02-01

    Basaltic volcanoes transfer volatiles from the mantle to the surface of the Earth. The quantification of deep volatile fluxes relies heavily on estimates of the volatile content of primitive magmas, the best archive of which is provided by melt inclusions. Available data from volcanoes producing mafic alkaline lavas in a range of tectonic settings suggest high volatile fluxes, but information remains sparse, particularly for intraplate ocean islands. Here we present measurements of volatile and trace element concentrations, as well as sulphur speciation, in olivine-hosted melt inclusions and matrix glasses from quenched basanite lava balloon samples from the 2011-2012 submarine eruption at El Hierro, Canary Islands. The results reveal remarkably high concentrations of dissolved volatiles and incompatible trace elements in this magma, with ∼80 ppm Nb and up to 3420 ppm CO2, 3.0 wt.% H2O and 5080 ppm S. Reconstructed primitive CO2 contents, considering CO2/Nb systematics and possible CO2 sequestration in shrinkage bubbles, reach weight percent levels, indicating that carbon is a major constituent of Canary Island magmas at depth and that exsolution of a CO2-rich fluid begins in the mantle at pressures in excess of 1 GPa. Correlations between sulphur concentration, sulphur speciation and water content suggest strong reduction of an initially oxidised mantle magma, likely controlled by coupled H2O and S degassing. This late-stage redox change may have triggered sulphide saturation, recorded by globular sulphide inclusions in clinopyroxene and ulvöspinel. The El Hierro basanite thus had a particularly high volatile-carrying capacity and released a minimum of 1.3-2.1 Tg CO2 and 1.8-2.9 Tg S to the environment, causing substantial stress on the local submarine ecosystem. These results highlight the important contribution of alkaline ocean island volcanoes, such as the Canary Islands, to volatile fluxes from the mantle.

  7. The submarine volcano eruption at the island of El Hierro: physical-chemical perturbation and biological response

    PubMed Central

    Fraile-Nuez, E.; González-Dávila, M.; Santana-Casiano, J. M.; Arístegui, J.; Alonso-González, I. J.; Hernández-León, S.; Blanco, M. J.; Rodríguez-Santana, A.; Hernández-Guerra, A.; Gelado-Caballero, M. D.; Eugenio, F.; Marcello, J.; de Armas, D.; Domínguez-Yanes, J. F.; Montero, M. F.; Laetsch, D. R.; Vélez-Belchí, P.; Ramos, A.; Ariza, A. V.; Comas-Rodríguez, I.; Benítez-Barrios, V. M.

    2012-01-01

    On October 10 2011 an underwater eruption gave rise to a novel shallow submarine volcano south of the island of El Hierro, Canary Islands, Spain. During the eruption large quantities of mantle-derived gases, solutes and heat were released into the surrounding waters. In order to monitor the impact of the eruption on the marine ecosystem, periodic multidisciplinary cruises were carried out. Here, we present an initial report of the extreme physical-chemical perturbations caused by this event, comprising thermal changes, water acidification, deoxygenation and metal-enrichment, which resulted in significant alterations to the activity and composition of local plankton communities. Our findings highlight the potential role of this eruptive process as a natural ecosystem-scale experiment for the study of extreme effects of global change stressors on marine environments. PMID:22768379

  8. Long-term volcanic hazard assessment on El Hierro (Canary Islands)

    NASA Astrophysics Data System (ADS)

    Becerril, L.; Bartolini, S.; Sobradelo, R.; Martí, J.; Morales, J. M.; Galindo, I.

    2014-07-01

    Long-term hazard assessment, one of the bastions of risk-mitigation programs, is required for land-use planning and for developing emergency plans. To ensure quality and representative results, long-term volcanic hazard assessment requires several sequential steps to be completed, which include the compilation of geological and volcanological information, the characterisation of past eruptions, spatial and temporal probabilistic studies, and the simulation of different eruptive scenarios. Despite being a densely populated active volcanic region that receives millions of visitors per year, no systematic hazard assessment has ever been conducted on the Canary Islands. In this paper we focus our attention on El Hierro, the youngest of the Canary Islands and the most recently affected by an eruption. We analyse the past eruptive activity to determine the spatial and temporal probability, and likely style of a future eruption on the island, i.e. the where, when and how. By studying the past eruptive behaviour of the island and assuming that future eruptive patterns will be similar, we aim to identify the most likely volcanic scenarios and corresponding hazards, which include lava flows, pyroclastic fallout and pyroclastic density currents (PDCs). Finally, we estimate their probability of occurrence. The end result, through the combination of the most probable scenarios (lava flows, pyroclastic density currents and ashfall), is the first qualitative integrated volcanic hazard map of the island.

  9. Modelling framework developed for managing and forecasting the El Hierro 2011-2014 unrest processes based on the analysis of the seismicity and deformation data rate.

    NASA Astrophysics Data System (ADS)

    Garcia, Alicia; Fernandez-Ros, Alberto; Berrocoso, Manuel; Marrero, Jose Manuel; Prates, Gonçalo; De la Cruz-Reyna, Servando; Ortiz, Ramon

    2014-05-01

    In July 2011 at El Hierro (Canary Islands, Spain), a volcanic unrest was detected, with significant deformations followed by increased seismicity. A submarine eruption started on 10 October 2011 and ceased on 5 March 2012, after the volcanic tremor signals persistently weakened through February 2012. However, the seismic activity did not end when the eruption, as several other seismic crises followed since. The seismic episodes presented a characteristic pattern: over a few days the number and magnitude of seismic event increased persistently, culminating in seismic events severe enough to be felt all over the island. In all cases the seismic activity was preceded by significant deformations measured on the island's surface that continued during the whole episode. Analysis of the available GNSS-GPS and seismic data suggests that several magma injection processes occurred at depth from the beginning of the unrest. A model combining the geometry of the magma injection process and the variations in seismic energy released has allowed successful forecasting of the new-vent opening. The model presented here places special emphasis on phenomena associated to moderate eruptions, as well as on volcano-tectonic earthquakes and landslides, which in some cases, as in El Hierro, may be more destructive than an eruption itself.

  10. The natural ocean acidification and fertilization event caused by the submarine eruption of El Hierro

    PubMed Central

    Santana-Casiano, J. M.; González-Dávila, M.; Fraile-Nuez, E.; de Armas, D.; González, A. G.; Domínguez-Yanes, J. F.; Escánez, J.

    2013-01-01

    The shallow submarine eruption which took place in October 10th 2011, 1.8 km south of the island of El Hierro (Canary Islands) allowed the study of the abrupt changes in the physical-chemical properties of seawater caused by volcanic discharges. In order to monitor the evolution of these changes, seven oceanographic surveys were carried out over six months (November 2011-April 2012) from the beginning of the eruptive stage to the post-eruptive phase. Here, we present dramatic changes in the water column chemistry including large decreases in pH, striking effects on the carbonate system, decreases in the oxygen concentrations and enrichment of Fe(II) and nutrients. Our findings highlight that the same volcano which was responsible for the creation of a highly corrosive environment, affecting marine biota, has also provided the nutrients required for the rapid recuperation of the marine ecosystem. PMID:23355953

  11. Emissions of Fe(II) and its kinetic of oxidation at Tagoro submarine volcano, El Hierro (Canary Islands)

    NASA Astrophysics Data System (ADS)

    González-Dávila, M.; Santana-González, C.; Santana-Casiano, J. M.

    2017-12-01

    The eruptive process that took place in October 2011 in the submarine volcano Tagoro off the Island of El Hierro (Canary Island) and the subsequent degasification stage, five months later, have increased the concentration of TdFe(II) (Total dissolved iron(II)) in the waters nearest to the volcanic edifice. In order to detect any variation in concentrations of TdFe(II) due to hydrothermal emissions, three cruises were carried out two years after the eruptive process in October 2013, March 2014, May 2015, March 2016 and November 2016. The results from these cruises confirmed important positive anomalies in TdFe(II), which coincided with negatives anomalies in pHF,is (pH in free scale, at in situ conditions) located in the proximity of the main cone. Maximum values in TdFe(II) both at the surface, associated to chlorophyll a maximum, and at the sea bottom, were also observed, showing the important influence of organic complexation and particle re-suspension processes. Temporal variability studies were carried out over periods ranging from hours to days in the stations located over the main and two secondary cones in the volcanic edifice with positive anomalies in TdFe(II) concentrations and negative anomalies in pHF,is values. Observations showed an important variability in both pHF,is and TdFe(II) concentrations, which indicated the volcanic area was affected by a degasification process that remained in the volcano after the eruptive phase had ceased. Fe(II) oxidation kinetic studies were also undertaken in order to analyze the effects of the seawater properties in the proximities of the volcano on the oxidation rate constants and t1/2 (half-life time) of ferrous iron. The increased TdFe(II) concentrations and the low associated pHF,is values acted as an important fertilization event in the seawater around the Tagoro volcano at the Island of El Hierro providing optimal conditions for the regeneration of the area.

  12. Development and recent activity of the San Andrés landslide on El Hierro, Canary Islands, Spain

    NASA Astrophysics Data System (ADS)

    Klimeš, Jan; Yepes, Jorge; Becerril, Laura; Kusák, Michal; Galindo, Inés; Blahut, Jan

    2016-05-01

    Extremely voluminous landslides with a long run-out (also known as megalandslides) on oceanic volcanic islands are infrequent denudational processes on such islands. At the same time, they represent a major geological hazard that must be looked into to avoid negative consequences for the inhabitants of these islands. Their occurrence can be related to periods of intense seismo-volcanic activity, similar to that which occurred on El Hierro Island over 2011-2012. Landslides on volcanic islands are studied using onshore and offshore geological, geophysical and geomorphological records, considering their unique triggering conditions (e.g. lava intrusions, eruptive vents, magma chamber collapses). Previous work has pointed out similarities between specific cases of landslides on volcanic islands and deep-seated gravitational slope deformations (DSGSDs) which are typical in high mountain settings. Nevertheless, the methodological approaches and concepts used to investigate DSGSDs are not commonly applied on volcanic islands studies, even though their use may provide new information about the development stage, recent movements and future hazards. Therefore, this approach for studying the San Andrés landslide (SAL) on El Hierro (Canary Islands) has been developed applying a detailed morphological field mapping, an interpretation of digital elevation models, structural measurements, kinematic testing, and a precise movement monitoring system. The acquired information revealed a strong structural influence on the landslide morphology and the presence of sets of weakened planes acting as the sliding surfaces of the SAL or secondary landslides within its body. The presence of secondary landslides, deep erosive gullies, coastal cliffs and high on-shore relative relief also suggests a high susceptibility to future landslide movement. Direct monitoring on the landslide scarps and the slip plane, performed between February 2013 and July 2014, using an automated optical

  13. Processes of Compression-Expansion and Subsidence-Uplift detected by the Spatial Inclinometer (IESHI) in the El Hierro Island eruption (October, 2011)

    NASA Astrophysics Data System (ADS)

    Prates, G.; Berrocoso, M.; Fernández-Ros, A.; García, A.; Ortiz, R.

    2012-04-01

    El Hierro Island (Canary Islands, Spain) has undergone a submarine eruption a few kilometers to its southeast, detected October 10, on the rift alignment that cuts across the island. However, the seismicity level suddenly increased around July 17 and ground deformation was detected by the only continuously observed GNSS-GPS (Global Navigation Satellite Systems - Global Positioning System) benchmark FRON in the El Golfo area. Based on that information several other GNSS-GPS benchmarks were installed, some of which continuously observed as well. A normal vector analysis was applied to these collected data. The normal vector magnitude variation identified local extension-compression regimes, while the normal vector inclination showed the relative height variation between the three benchmarks that define the plan to which normal vector is analyzed. To accomplish this analysis the data was previously processed to achieve positioning solutions every 30 minutes using the Bernese GPS Software 5.0, further enhanced by a Discrete Kalman Filter, giving an overall millimeter level precision. These solutions were reached using the IGS (International GNSS Service) ultra-rapid orbits and the double-differenced ionosphere-free combination. With this strategy the positioning solutions were attained in near real-time. Later with the IGS rapid orbits the data was reprocessed to provide added confidence to the solutions. Two triangles were then considered, a smaller one located in the El Golfo area within the historically collapsed caldera, and a larger one defined by benchmarks placed in Valverde, El Golfo and La Restinga, the town closest to the eruption's location, covering almost the entire Island's surface above sea level. With these two triangles the pre-eruption and post-eruption deformation suffered by El Hierro's surface will be further analyzed.

  14. The 2011 El Hierro submarine eruption: estimation of erupted lava flow volume on the basis of helicopter thermal surveys

    NASA Astrophysics Data System (ADS)

    Hernández, P. A.; Calvari, S.; Calvo, D.; Marquez, A.; Padron, E.; Pérez, N.; Melian, G.; Padilla, G.; Barrancos, J.; Dionis, S.; Rodríguez, F.; Nolasco, D.; Hernández, I.

    2012-04-01

    El Hierro represents the summit of a volcanic shield elevating from the surrounding seafloor at depth of 4000 m to up to 1501 m above sea level. The island is believed to be near the present hotspot location in the Canaries with the oldest subaerial rocks dated at 1.12 Ma. The subaerial parts of the El Hierro rift zones (NE, NW and S Ridges) are characterized by tightly aligned dyke complexes with clusters of cinder cones as their surface expressions. Since 16 July, an anomalous seismicity at El Hierro Island was recorded by IGN seismic network. After the occurrence of more than 10,000 seismic events, volcanic tremor started at 05:15 on 10 October, followed on the afternoon of 12 October by a green discolouration of seawater, strong bubbling and degassing, and abundant bombs on a decimetre scale found floating on the ocean surface offshore, southwest of La Restinga village. The Canary Government raised the alert level from green to yellow on 10 October (3 colour basis: green, yellow, and red). Further episodes have occurred during November, December 2011 and January 2012, with turbulent water, foam rings, and volcanic material again reaching the sea surface. Colour of the discoloured area has changed frequently from light green to dark brown, depending on the eruptive activity. During the whole eruptive period, The Volcanological Institute of Canary Islands and the Helicopter Unit of the Spanish Civil Guard have carried out regularly thermal surveys with a hand held FLIR Thermal Camera P65. The images have been collected taking care of avoiding solar reflection (with cloudy weather) or at times of the day without direct sun light. Air temperature and humidity were measured with a handled thermo-hygrometer every time before the thermal image collection, and measurements were always performed at two fixed heights: 2000 and 1000 feet, and images were collected as perpendicular as possible to the surface. Together with thermal images, digital photos of the surface have

  15. Deployment of a seismic array for volcano monitoring during the ongoing submarine eruption at El Hierro, Canary Islands

    NASA Astrophysics Data System (ADS)

    Abella, R.; Almendros, J.; Carmona, E.; Martin, R.

    2012-04-01

    On 17 July 2011 there was an important increase of the seismic activity at El Hierro (Canary Islands, Spain). This increase was detected by the Volcano Monitoring Network (Spanish national seismic network) run by the Instituto Geográfico Nacional (IGN). As a consequence, the IGN immediately deployed a dense, complete monitoring network that included seismometers, GPS stations, geochemical equipment, magnetometers, and gravity meters. During the first three months of activity, the seismic network recorded over ten thousand volcano-tectonic earthquakes, with a maximum magnitude of 4.6. On 10 October 2011 an intense volcanic tremor started. It was a monochromatic signal, with variable amplitude and frequency content centered at about 1-2 Hz. The tremor onset was correlated with the initial stages of the submarine eruption that occurred from a vent located south of El Hierro island, near the village of La Restinga. At that point the IGN, in collaboration with the Instituto Andaluz de Geofísica, deployed a seismic array intended for volcanic tremor monitoring and analysis. The seismic array is located about 7 km NW of the submarine vent. It has a 12-channel, 24-bit data acquisition system sampling each channel at 100 sps. The array is composed by 1 three-component and 9 vertical-component seismometers, distributed in a flat area with an aperture of 360 m. The data provided by the seismic array are going to be processed using two different approaches: (1) near-real-time, to produce information that can be useful in the management of the volcanic crisis; and (2) detailed investigations, to study the volcanic tremor characteristics and relate them to the eruption dynamics. At this stage we are mostly dedicated to produce fast, near-real-time estimates. Preliminary results have been obtained using the maximum average cross-correlation method. They indicate that the tremor wavefronts are highly coherent among array stations and propagate across the seismic array with an

  16. Improvement forecasting of volcanic activity by applying a Kalman filter to the SSEM signal. The case of the El Hierro Island eruption (October 2011)

    NASA Astrophysics Data System (ADS)

    Garcia, A.; Berrocoso, M.; Marrero, J. M.; Ortiz, R.

    2012-04-01

    The FFM (Failure Forecast Method) is developed from the eruption of St. Helens, being repeatedly applied to forecast eruptions and recently to the prediction of seismic activity in active volcanic areas. The underwater eruption of El Hierro Island has been monitored from three months before starting (October 10, 2011). This allowed a large catalogue of seismic events (over 11000) and continuous recording seismic signals that cover the entire period. Since the beginning of the seismic-volcanic crisis (July 2011), the FFM was applied to the SSEM signal of seismic records. Mainly because El Hierro is a very small island, the SSEM has a high noise (traffic and oceanic noise). To improve the signal / noise ratio has been used a Kalman filter. The Kalman filter coefficients are adjusted using an inversion process based on forecasting errors occurred in the twenty days preceding. The application of this filter has been a significant improvement in the reliability of forecasts. The analysis of the results shows, before the start of the eruption, that 90% of the forecasts are obtained with errors less than 10 minutes with more than 24 hours in advance. It is noteworthy that the method predicts the events of greater magnitude and especially the beginning of each swarm of seismic events. At the time the eruption starts reducing the efficiency of the forecast 50% with a dispersion of more than one hour. This fact is probably due to decreased detectability by saturation of some of the seismic stations and decreased the average magnitude. However, the events of magnitude greater than 4 were predicted with an error less than 20 minutes.

  17. Monitoring El Hierro submarine volcanic eruption events with a submarine seismic array

    NASA Astrophysics Data System (ADS)

    Jurado, Maria Jose; Molino, Erik; Lopez, Carmen

    2013-04-01

    A submarine volcanic eruption took place near the southernmost emerged land of the El Hierro Island (Canary Islands, Spain), from October 2011 to February 2012. The Instituto Geografico Nacional (IGN) seismic stations network evidenced seismic unrest since July 2012 and was a reference also to follow the evolution of the seismic activity associated with the volcanic eruption. From the beginning of the eruption a geophone string was installed less than 2 km away from the new volcano, next to La Restinga village shore, to record seismic activity related to the volcanic activity, continuously and with special interest on high frequency events. The seismic array was endowed with 8, high frequency, 3 component, 250 Hz, geophone cable string with a separation of 6 m between them. The analysis of the dataset using spectral techniques allows the characterization of the different phases of the eruption and the study of its dynamics. The correlation of the data analysis results with the observed sea surface activity (ash and lava emission and degassing) and also with the seismic activity recorded by the IGN field seismic monitoring system, allows the identification of different stages suggesting the existence of different signal sources during the volcanic eruption and also the posteruptive record of the degassing activity. The study shows that the high frequency capability of the geophone array allow the study of important features that cannot be registered by the standard seismic stations. The accumulative spectral amplitude show features related to eruptive changes.

  18. Volcanic signatures in time gravity variations during the volcanic unrest on El Hierro (Canary Islands)

    NASA Astrophysics Data System (ADS)

    Sainz-Maza Aparicio, S.; Arnoso Sampedro, J.; Gonzalez Montesinos, F.; Martí Molist, J.

    2014-06-01

    Gravity changes occurring during the initial stage of the 2011-2012 El Hierro submarine eruption are interpreted in terms of the preeruptive signatures during the episode of unrest. Continuous gravity measurements were made at two sites on the island using the relative spring gravimeter LaCoste and Romberg gPhone-054. On 15 September 2011, an observed gravity decrease of 45 μGal, associated with the southward migration of seismic epicenters, is consistent with a lateral magma migration that occurred beneath the volcanic edifice, an apparently clear precursor of the eruption that took place 25 days later on 10 October 2011. High-frequency gravity signals also appeared on 6-11 October 2011, pointing to an occurring interaction between a magmatic intrusion and the ocean floor. These important gravity changes, with amplitudes varying from 10 to -90 μGal, during the first 3 days following the onset of the eruption are consistent with the northward migration of the eruptive focus along an active eruptive fissure. An apparent correlation of gravity variations with body tide vertical strain was also noted, which could indicate that concurrent tidal triggering occurred during the initial stage of the eruption.

  19. Searching for structural medium changes during the 2011 El Hierro (Spain) submarine eruption

    NASA Astrophysics Data System (ADS)

    Sánchez-Pastor, Pilar S.; Schimmel, Martin; López, Carmen

    2017-04-01

    Submarine volcanic eruptions are often difficult to study due to their restricted access that usually inhibits direct observations. That happened with the 2011 El Hierro eruption, which is the first eruption that has been tracked in real time in Canary Islands. For instance, despite the real-time tracking it was not possible to determine the exact end of the eruption. Besides, volcanic eruptions involve many dynamic (physical and chemical) processes, which cause structural changes in the surrounding medium that we expect to observe and monitor through passive seismic approaches. The purpose of this study is to detect and analyse these changes as well as to search for precursory signals to the eruption itself using ambient noise auto and cross-correlations. We employ different correlation strategies (classical and phase cross-correlation) and apply them to field data recorded by the IGN network during 2011 and 2012. The different preprocessing and processing steps are tested and compared to better understand the data, to find the robust signatures, and to define a routine work procedure. One of the problems we face is the presence of volcanic tremors, which cause a varying seismic response that we can not attribute to structural changes. So far, structural changes could not be detected unambiguously and we present our ongoing research in this field.

  20. Multi-event behavior of El Golfo landslide (El Hierro Island, Canary Archipelago)

    NASA Astrophysics Data System (ADS)

    León, Ricardo; Biain, Ander; Urgeles, Roger; Somoza, Luis; Ferrer, Mercedes; García-Crespo, Jesús; Francisco Mediato, José; Galindo, Inés; Yepes, Jorge; Gimenez-Moreno, Julia

    2017-04-01

    Based on the re-interpretation of a vast onshore-offshore data set, a new morpho-structural characterization of the El Golfo giant landslide in the island of El Hierro (Canary Archipelago, Spain) is presented. Offshore multibeam echosounder data, chirp sub-bottom profiles, multichannel seismic reflection data and onshore information from water wells and galleries have been analyzed to determine the nature of the event. The subaerial headscarp shows a non-continuous arcuate profile formed by two nested semi-circular amphitheaters that extend offshore along a smooth chute, suggesting the occurrence of at least two large retrogressive events. Channels/gullies and escarpments developed along the submarine sector of the scar also indicate smaller-scale events and predominance of sediment bypass. At the base of submerged island, two subunits within the related submarine mass transport deposit (MTD) are identified on multichannel seismic reflection profiles confirming the multi-event nature of the landslide. The MTD, identified as a debris avalanche, has a total estimated volume of 318 km3: 84 km3 and 234 km3, for the lower and upper subunits respectively. Data from wells and galleries show abrasion platforms with beach deposits at sea-level (0 masl) formed after the landslide scar and buried by the El Golfo post-collapse infill lavas, suggesting an age at least older than 23.5-82.5 ka for the landslide. This work has been supported by the projects IGCP-640 S4SLIDE, High resolution seabed mapping EASME/EMFF/2016/005 and CTM2010-09496-E. Keywords: Submarine landslides, volcanic islands, debris avalanche, Canary Islands

  1. Lack of impact of the El Hierro (Canary Islands) submarine volcanic eruption on the local phytoplankton community.

    PubMed

    Gómez-Letona, M; Arístegui, J; Ramos, A G; Montero, M F; Coca, J

    2018-03-16

    The eruption of a submarine volcano south of El Hierro Island (Canary Islands) in October 2011 led to major physical and chemical changes in the local environment. Large amounts of nutrients were found at specific depths in the water column above the volcano associated with suboxic layers resulting from the oxidation of reduced chemical species expelled during the eruptive phase. It has been suggested that the fertilization with these compounds enabled the rapid restoration of the ecosystem in the marine reserve south of the island once the volcanic activity ceased, although no biological evidence for this has been provided yet. To test the biological fertilization hypothesis on the pelagic ecosystem, we studied the evolution and variability in chlorophyll a, from in situ and remote sensing data, combined with information on phytoplankton and bacterial community structure during and after the eruptive episode. Remote sensing and in situ data revealed that no phytoplankton bloom took place neither during nor after the eruptive episode. We hypothesize that the fertilization by the volcano did not have an effect in the phytoplankton community due to the strong dilution of macro- and micronutrients caused by the efficient renewal of ambient waters in the zone.

  2. The Submarine Volcano Eruption off El Hierro Island: Effects on the Scattering Migrant Biota and the Evolution of the Pelagic Communities

    PubMed Central

    Ariza, Alejandro; Kaartvedt, Stein; Røstad, Anders; Garijo, Juan Carlos; Arístegui, Javier; Fraile-Nuez, Eugenio; Hernández-León, Santiago

    2014-01-01

    The submarine volcano eruption off El Hierro Island (Canary Islands) on 10 October 2011 promoted dramatic perturbation of the water column leading to changes in the distribution of pelagic fauna. To study the response of the scattering biota, we combined acoustic data with hydrographic profiles and concurrent sea surface turbidity indexes from satellite imagery. We also monitored changes in the plankton and nekton communities through the eruptive and post-eruptive phases. Decrease of oxygen, acidification, rising temperature and deposition of chemicals in shallow waters resulted in a reduction of epipelagic stocks and a disruption of diel vertical migration (nocturnal ascent) of mesopelagic organisms. Furthermore, decreased light levels at depth caused by extinction in the volcanic plume resulted in a significant shallowing of the deep acoustic scattering layer. Once the eruption ceased, the distribution and abundances of the pelagic biota returned to baseline levels. There was no evidence of a volcano-induced bloom in the plankton community. PMID:25047077

  3. The submarine volcano eruption off El Hierro Island: effects on the scattering migrant biota and the evolution of the pelagic communities.

    PubMed

    Ariza, Alejandro; Kaartvedt, Stein; Røstad, Anders; Garijo, Juan Carlos; Arístegui, Javier; Fraile-Nuez, Eugenio; Hernández-León, Santiago

    2014-01-01

    The submarine volcano eruption off El Hierro Island (Canary Islands) on 10 October 2011 promoted dramatic perturbation of the water column leading to changes in the distribution of pelagic fauna. To study the response of the scattering biota, we combined acoustic data with hydrographic profiles and concurrent sea surface turbidity indexes from satellite imagery. We also monitored changes in the plankton and nekton communities through the eruptive and post-eruptive phases. Decrease of oxygen, acidification, rising temperature and deposition of chemicals in shallow waters resulted in a reduction of epipelagic stocks and a disruption of diel vertical migration (nocturnal ascent) of mesopelagic organisms. Furthermore, decreased light levels at depth caused by extinction in the volcanic plume resulted in a significant shallowing of the deep acoustic scattering layer. Once the eruption ceased, the distribution and abundances of the pelagic biota returned to baseline levels. There was no evidence of a volcano-induced bloom in the plankton community.

  4. Petrological and geochemical Highlights in the floating fragments of the October 2011 submarine eruption offshore El Hierro (Canary Islands): Relevance of submarine hydrothermal processes

    NASA Astrophysics Data System (ADS)

    Rodriguez-Losada, Jose A.; Eff-Darwich, Antonio; Hernandez, Luis E.; Viñas, Ronaldo; Pérez, Nemesio; Hernandez, Pedro; Melián, Gladys; Martinez-Frías, Jesús; Romero-Ruiz, M. Carmen; Coello-Bravo, Juan Jesús

    2015-02-01

    This paper describes the main physical, petrological and geochemical features of the floating fragments that were emitted in the initial stages of the 2011-2012 submarine eruption off the coast of the Canarian island of El Hierro, located 380 km from the Northwest African Coast. It attempts to assess the potential of radiometric analyses to discern the intriguing origin of the floating fragments and the differences between their constituent parts. In this regard, the material that conforms the core of the fragments contains the largest concentration of uranium (U) ever found in volcanic rocks of the Canary Islands. This enrichment in U is not found in the content of thorium (Th), hence the floating fragments have an unusual U/Th ratio, namely equal to or larger than 3. Although the origin of this material is under discussion, it is proposed that the enrichment in U is the result of hydrothermal processes.

  5. Different deformation patterns using GPS in the volcanic process of El Hierro (Canary Island) 2011-2013

    NASA Astrophysics Data System (ADS)

    García-Cañada, Laura; José García-Arias, María; Pereda de Pablo, Jorge; Lamolda, Héctor; López, Carmen

    2014-05-01

    Ground deformation is one of the most important parameter in volcano monitoring. The detected deformations in volcanic areas can be precursors of a volcanic activity and contribute with useful information to study the evolution of an unrest, eruption or any volcanic process. GPS is the most common technique used to measure volcano deformations. It can be used to detect slow displacement rates or much larger and faster deformations associated with any volcanic process. In volcanoes the deformation is expected to be a mixed of nature; during periods of quiescence it will be slow or not present, while increased activity slow displacement rates can be detected or much larger and faster deformations can be measure due to magma intrusion, for example in the hours to days prior a eruption beginning. In response to the anomalous seismicity detected at El Hierro in July 2011, the Instituto Geográfico Nacional (IGN) improved its volcano monitoring network in the island with continuous GPS that had been used to measure the ground deformation associated with the precursory unrest since summer 2011, submarine eruption (October 2011-March 2012) and the following unrest periods (2012-2013). The continuous GPS time series, together with other techniques, had been used to evaluate the activity and to detect changes in the process. We investigate changes in the direction and module of the deformation obtained by GPS and they show different patterns in every unrest period, very close to the seismicity locations and migrations.

  6. Portable exhausters POR-004 SKID B, POR-005 SKID C, POR-006 SKID D storage plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nelson, O.D.

    1997-09-04

    This document provides a storage plan for portable exhausters POR-004 SKID B, POR-005 SKID C, AND POR-006 SKID D. The exhausters will be stored until they are needed by the TWRS (Tank Waste Remediation Systems) Saltwell Pumping Program. The storage plan provides criteria for portable exhauster storage, periodic inspections during storage, and retrieval from storage.

  7. [Lung transplantation in cystic fibrosis. The results of the Clínica Puerta de Hierro (Madrid) and the Hospital La Fe (Valencia)].

    PubMed

    Lázaro-Carrasco, M T; Morales, P; Ferreiro, M J; Borro, J M; Varela, A; Vicente, R; Ramos, F; Estada, J A

    1999-05-01

    Retrospective analysis of cystic fibrosis patients who underwent pulmonary transplantation at Clínica Puerta de Hierro, Madrid, and at Hospital La Fe, Valencia. Since the beginning of the programme and until March 1998, a total of 63 patients with cystic fibrosis were studied. Among transplanted patients, 18 were males and 16 females, with a mean age of 18.9 years. All patients underwent sequential bilateral pulmonary transplantation. After transplantation, the most common complication was bacterial pneumonia which affected all patients. Six patients had dehiscence or stenosis of the bronchial suture. Other specific complications of this condition by frequency were intestinal obstruction and diabetes mellitus. Six patients developed obliterans bronchiolitis and one of them underwent a repeat transplantation. Three out of the 34 patients died, and the likelihood of survival after one and three years was 94%. Respiratory function tests and PaO2 peaked at sixth post-transplantation month. Pulmonary transplantation is a therapeutic option to be considered for the patient with cystic fibrosis and severe involvement of his/her pulmonary disease.

  8. Focal mechanism of the seismic series prior to the 2011 El Hierro eruption

    NASA Astrophysics Data System (ADS)

    del Fresno, C.; Buforn, E.; Cesca, S.; Domínguez Cerdeña, I.

    2015-12-01

    The onset of the submarine eruption of El Hierro (10-Oct-2011) was preceded by three months of low-magnitude seismicity (Mw<4.0) characterized by a well documented hypocenter migration from the center to the south of the island. Seismic sources of this series have been studied in order to understand the physical process of magma migration. Different methodologies were used to obtain focal mechanisms of largest shocks. Firstly, we have estimated the joint fault plane solutions for 727 shocks using first motion P polarities to infer the stress pattern of the sequence and to determine the time evolution of principle axes orientation. Results show almost vertical T-axes during the first two months of the series and horizontal P-axes on N-S direction coinciding with the migration. Secondly, a point source MT inversion was performed with data of the largest 21 earthquakes of the series (M>3.5). Amplitude spectra was fitted at local distances (<20km). Reliability and stability of the results were evaluated with synthetic data. Results show a change in the focal mechanism pattern within the first days of October, varying from complex sources of higher non-double-couple components before that date to a simpler strike-slip mechanism with horizontal tension axes on E-W direction the week prior to the eruption onset. A detailed study was carried out for the 8 October 2011 earthquake (Mw=4.0). Focal mechanism was retrieved using a MT inversion at regional and local distances. Results indicate an important component of strike-slip fault and null isotropic component. The stress pattern obtained corresponds to horizontal compression in a NNW-SSE direction, parallel to the southern ridge of the island, and a quasi-horizontal extension in an EW direction. Finally, a simple source time function of 0.3s has been estimated for this shock using the Empirical Green function methodology.

  9. Fast-Turnoff Transient Electro-Magnetic (TEM) geophysical survey in the Peña de Hierro ("Berg of Iron") field area of the Mars Analog Research and Technology Experiment (MARTE)

    NASA Astrophysics Data System (ADS)

    Jernsletten, J. A.

    2004-12-01

    This report describes the outcome of a Fast-Turnoff Transient Electro-Magnetic (TEM) geophysical survey carried out in the Peña de Hierro ("Berg of Iron") field area of the Mars Analog Research and Technology Experiment (MARTE), during May and June of 2003. The MARTE Peña de Hierro field area is located between the towns of Rio Tinto and Nerva in the Andalucia region of Spain. It is about one hour drive West of the city of Sevilla, and also about one hour drive North of Huelva. The high concentration of dissolved iron (and smaller amounts of other metals) in the very acidic water in the Rio Tinto area gives the water its characteristic wine red color, and also means that the water is highly conductive, and such an acidic and conductive fluid is highly suited for exploration by electromagnetic methods. This naturally acidic environment is maintained by bacteria in the groundwater and it is these bacteria that are the main focus of the MARTE project overall, and of this supporting geophysical work. It is the goal of this study to be able to map the subsurface extent of the high conductivity (low resistivity) levels, and thus by proxy the subsurface extent of the acidic groundwater and the bacteria populations. In so doing, the viability of using electromagnetic methods for mapping these subsurface metal-rich water bodies is also examined and demonstrated, and the geophysical data will serve to support drilling efforts. The purpose of this field survey was an initial effort to map certain conductive features in the field area, in support of the drilling operations that are central to the MARTE project. These conductive features include the primary target of exploration for MARTE, the very conductive acidic groundwater in the area (which is extremely rich in metals). Other conductive features include the pyretic ore bodies in the area, as well as extensive mine tailings piles.

  10. Applying Fractal Dimensions and Energy-Budget Analysis to Characterize Fracturing Processes During Magma Migration and Eruption: 2011-2012 El Hierro (Canary Islands) Submarine Eruption

    NASA Astrophysics Data System (ADS)

    López, Carmen; Martí, Joan; Abella, Rafael; Tarraga, Marta

    2014-07-01

    The impossibility of observing magma migration inside the crust obliges us to rely on geophysical data and mathematical modelling to interpret precursors and to forecast volcanic eruptions. Of the geophysical signals that may be recorded before and during an eruption, deformation and seismicity are two of the most relevant as they are directly related to its dynamic. The final phase of the unrest episode that preceded the 2011-2012 eruption on El Hierro (Canary Islands) was characterized by local and accelerated deformation and seismic energy release indicating an increasing fracturing and a migration of the magma. Application of time varying fractal analysis to the seismic data and the characterization of the seismicity pattern and the strain and the stress rates allow us to identify different stages in the source mechanism and to infer the geometry of the path used by the magma and associated fluids to reach the Earth's surface. The results obtained illustrate the relevance of such studies to understanding volcanic unrest and the causes that govern the initiation of volcanic eruptions.

  11. A new Volcanic managEment Risk Database desIgn (VERDI): Application to El Hierro Island (Canary Islands)

    NASA Astrophysics Data System (ADS)

    Bartolini, S.; Becerril, L.; Martí, J.

    2014-11-01

    One of the most important issues in modern volcanology is the assessment of volcanic risk, which will depend - among other factors - on both the quantity and quality of the available data and an optimum storage mechanism. This will require the design of purpose-built databases that take into account data format and availability and afford easy data storage and sharing, and will provide for a more complete risk assessment that combines different analyses but avoids any duplication of information. Data contained in any such database should facilitate spatial and temporal analysis that will (1) produce probabilistic hazard models for future vent opening, (2) simulate volcanic hazards and (3) assess their socio-economic impact. We describe the design of a new spatial database structure, VERDI (Volcanic managEment Risk Database desIgn), which allows different types of data, including geological, volcanological, meteorological, monitoring and socio-economic information, to be manipulated, organized and managed. The root of the question is to ensure that VERDI will serve as a tool for connecting different kinds of data sources, GIS platforms and modeling applications. We present an overview of the database design, its components and the attributes that play an important role in the database model. The potential of the VERDI structure and the possibilities it offers in regard to data organization are here shown through its application on El Hierro (Canary Islands). The VERDI database will provide scientists and decision makers with a useful tool that will assist to conduct volcanic risk assessment and management.

  12. Portable exhauster POR-007/Skid E and POR-008/Skid F storage plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nelson, O.D.

    1998-07-25

    This document provides storage requirements for 1,000 CFM portable exhausters POR-O07/Skid E and POR-008/Skid F. These requirements are presented in three parts: preparation for storage, storage maintenance and testing, and retrieval from storage. The exhauster component identification numbers listed in this document contain the prefix POR-007 or POR-008 depending on which exhauster is being used.

  13. Evolution of submarine eruptive activity during the 2011-2012 El Hierro event as documented by hydroacoustic images and remotely operated vehicle observations

    NASA Astrophysics Data System (ADS)

    Somoza, L.; González, F. J.; Barker, S. J.; Madureira, P.; Medialdea, T.; de Ignacio, C.; Lourenço, N.; León, R.; Vázquez, J. T.; Palomino, D.

    2017-08-01

    Submarine volcanic eruptions are frequent and important events, yet they are rarely observed. Here we relate bathymetric and hydroacoustic images from the 2011 to 2012 El Hierro eruption with surface observations and deposits imaged and sampled by ROV. As a result of the shallow submarine eruption, a new volcano named Tagoro grew from 375 to 89 m depth. The eruption consisted of two main phases of edifice construction intercalated with collapse events. Hydroacoustic images show that the eruptions ranged from explosive to effusive with variable plume types and resulting deposits, even over short time intervals. At the base of the edifice, ROV observations show large accumulations of lava balloons changing in size and type downslope, coinciding with the area where floating lava balloon fallout was observed. Peaks in eruption intensity during explosive phases generated vigorous bubbling at the surface, extensive ash, vesicular lapilli and formed high-density currents, which together with periods of edifice gravitational collapse, produced extensive deep volcaniclastic aprons. Secondary cones developed in the last stages and show evidence for effusive activity with lava ponds and lava flows that cover deposits of stacked lava balloons. Chaotic masses of heterometric boulders around the summit of the principal cone are related to progressive sealing of the vent with decreasing or variable magma supply. Hornitos represent the final eruptive activity with hydrothermal alteration and bacterial mats at the summit. Our study documents the distinct evolution of a submarine volcano and highlights the range of deposit types that may form and be rapidly destroyed in such eruptions.Plain Language SummaryToday and through most of geological history, the greatest number and volume of volcanic eruptions on Earth have occurred underwater. However, in comparison to subaerial eruption, little is known about submarine eruptive processes as</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2011-02-08/pdf/2011-2746.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2011-02-08/pdf/2011-2746.pdf"><span>76 FR 6843 - Additional Designations, Foreign Narcotics Kingpin Designation Act</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2011-02-08</p> <p>..., Jaslico, Mexico; Vereda Del Canario 1, Guadalajara, Jalisco, Mexico; Puerto de <span class="hlt">Hierro</span>, Zapopan, Jalisco..., Jalisco, Mexico; Puerto de <span class="hlt">Hierro</span>, Zapopan, Jalisco, Mexico; Mexico City, Distrito Federal, Mexico.... RODRIGUEZ OLIVERA, Daniel (a.k.a. RODRIGUEZ MORFIN, Daniel), Puerto de <span class="hlt">Hierro</span>, Zapopan, Jalisco, Mexico...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017EGUGA..19.6282D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017EGUGA..19.6282D"><span>Improvements on the seismic catalog previous to the 2011 El <span class="hlt">Hierro</span> eruption.</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Domínguez Cerdeña, Itahiza; del Fresno, Carmen</p> <p>2017-04-01</p> <p>Precursors from the submarine eruption of El <span class="hlt">Hierro</span> (Canary Islands) in 2011 included 10,000 low magnitude earthquakes and 5 cm crustal deformation within 81 days previous to the eruption onset on the 10th October. Seismicity revealed a 20 km horizontal migration from the North to the South of the island and depths ranging from 10 and 17 km with deeper events occurring further South. The earthquakes of the seismic catalog were manually picked by the IGN almost in real time, but there has not been a subsequent revision to check for new non located events jet and the completeness magnitude for the seismic catalog have strong changes during the entire swarm due to the variable number of events per day. In this work we used different techniques to improve the quality of the seismic catalog. First we applied different automatic algorithms to detect new events including the LTA-STA method. Then, we performed a semiautomatic system to correlate the new P and S detections with known phases from the original catalog. The new detected earthquakes were also located using Hypoellipse algorithm. The resulting new catalog included 15,000 new events mainly concentrated in the last weeks of the swarm and we assure a completeness magnitude of 1.2 during the whole series. As the seismicity from the original catalog was already relocated using hypoDD algorithm, we improved the location of the new events using a master-cluster relocation. This method consists in relocating earthquakes towards a cluster of well located events instead of a single event as the master-event method. In our case this cluster correspond to the relocated earthquakes from the original catalog. Finally, we obtained a new equation for the local magnitude estimation which allow us to include corrections for each seismic station in order to avoid local effects. The resulting magnitude catalog has a better fit with the moment magnitude catalog obtained for the strong earthquakes of this series in previous studies</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24161241','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24161241"><span>On the biology of Spiruroidea parasites of murine rodents on El <span class="hlt">Hierro</span> (Canary Islands, Spain) with molecular characterization of Streptopharagus greenbergi Wertheim, 1993.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Montoliu, Isabel; Sánchez, Santiago; Villa, Mercedes; Abreu-Acosta, Néstor; Martín-Alonso, Aarón; Fernández-Álvarez, Ángela; Foronda, Pilar</p> <p>2013-09-01</p> <p>This paper reports the role of darkling beetles Pimelia laevigata costipennis and Hegeter amaroides (Tenebrionidae) as intermediate hosts of spiruroid nematodes parasites of the black rat and house mouse of El <span class="hlt">Hierro</span> (Canary Islands). Larvae of spiruroid species were found in the two tenebrionids (18.1% in P. l. costipennis, 7.8% in H. amaroides), Streptopharagus greenbergi being predominant in both (16.1% and 7.1%, respectively), ahead of Mastophorus muris and Gongylonema type larva. The larval stages of S. greenbergi are described for the first time, and adult worms were obtained experimentally from an infected laboratory rat, allowing the identification of the species. Morphometric measurements of experimental adults match those of adults detected in naturally infected rats on the island. Molecular data for S. greenbergi, and the ITS nucleotide sequence of the genus Streptopharagus are also provided for the first time. After the isolation of S. greenbergi DNA and amplification of the ITS region, the ITS1 of this spirocercid was sequenced and deposited in the GenBank database. Copyright © 2013 Académie des sciences. Published by Elsevier SAS. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25671714','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25671714"><span>Transient changes in bacterioplankton communities induced by the submarine volcanic eruption of El <span class="hlt">Hierro</span> (Canary Islands).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ferrera, Isabel; Arístegui, Javier; González, José M; Montero, María F; Fraile-Nuez, Eugenio; Gasol, Josep M</p> <p>2015-01-01</p> <p>The submarine volcanic eruption occurring near El <span class="hlt">Hierro</span> (Canary Islands) in October 2011 provided a unique opportunity to determine the effects of such events on the microbial populations of the surrounding waters. The birth of a new underwater volcano produced a large plume of vent material detectable from space that led to abrupt changes in the physical-chemical properties of the water column. We combined flow cytometry and 454-pyrosequencing of 16S rRNA gene amplicons (V1-V3 regions for Bacteria and V3-V5 for Archaea) to monitor the area around the volcano through the eruptive and post-eruptive phases (November 2011 to April 2012). Flow cytometric analyses revealed higher abundance and relative activity (expressed as a percentage of high-nucleic acid content cells) of heterotrophic prokaryotes during the eruptive process as compared to post-eruptive stages. Changes observed in populations detectable by flow cytometry were more evident at depths closer to the volcano (~70-200 m), coinciding also with oxygen depletion. Alpha-diversity analyses revealed that species richness (Chao1 index) decreased during the eruptive phase; however, no dramatic changes in community composition were observed. The most abundant taxa during the eruptive phase were similar to those in the post-eruptive stages and to those typically prevalent in oceanic bacterioplankton communities (i.e. the alphaproteobacterial SAR11 group, the Flavobacteriia class of the Bacteroidetes and certain groups of Gammaproteobacteria). Yet, although at low abundance, we also detected the presence of taxa not typically found in bacterioplankton communities such as the Epsilonproteobacteria and members of the candidate division ZB3, particularly during the eruptive stage. These groups are often associated with deep-sea hydrothermal vents or sulfur-rich springs. Both cytometric and sequence analyses showed that once the eruption ceased, evidences of the volcano-induced changes were no longer observed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4324844','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4324844"><span>Transient Changes in Bacterioplankton Communities Induced by the Submarine Volcanic Eruption of El <span class="hlt">Hierro</span> (Canary Islands)</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ferrera, Isabel; Arístegui, Javier; González, José M.; Montero, María F.; Fraile-Nuez, Eugenio; Gasol, Josep M.</p> <p>2015-01-01</p> <p>The submarine volcanic eruption occurring near El <span class="hlt">Hierro</span> (Canary Islands) in October 2011 provided a unique opportunity to determine the effects of such events on the microbial populations of the surrounding waters. The birth of a new underwater volcano produced a large plume of vent material detectable from space that led to abrupt changes in the physical-chemical properties of the water column. We combined flow cytometry and 454-pyrosequencing of 16S rRNA gene amplicons (V1–V3 regions for Bacteria and V3–V5 for Archaea) to monitor the area around the volcano through the eruptive and post-eruptive phases (November 2011 to April 2012). Flow cytometric analyses revealed higher abundance and relative activity (expressed as a percentage of high-nucleic acid content cells) of heterotrophic prokaryotes during the eruptive process as compared to post-eruptive stages. Changes observed in populations detectable by flow cytometry were more evident at depths closer to the volcano (~70–200 m), coinciding also with oxygen depletion. Alpha-diversity analyses revealed that species richness (Chao1 index) decreased during the eruptive phase; however, no dramatic changes in community composition were observed. The most abundant taxa during the eruptive phase were similar to those in the post-eruptive stages and to those typically prevalent in oceanic bacterioplankton communities (i.e. the alphaproteobacterial SAR11 group, the Flavobacteriia class of the Bacteroidetes and certain groups of Gammaproteobacteria). Yet, although at low abundance, we also detected the presence of taxa not typically found in bacterioplankton communities such as the Epsilonproteobacteria and members of the candidate division ZB3, particularly during the eruptive stage. These groups are often associated with deep-sea hydrothermal vents or sulfur-rich springs. Both cytometric and sequence analyses showed that once the eruption ceased, evidences of the volcano-induced changes were no longer observed</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29465251','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29465251"><span>Managing iron deficiency and iron deficiency anemia in inflammatory bowel disease. The results of the "Gestiona <span class="hlt">hierro</span>-EII" survey.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Casellas Jordá, Francesc; Vera Mendoza, Isabel; Barreiro-de Acosta, Manuel; Vázquez Morón, Juan María; López Román, Javier; Júdez Gutiérrez, Javier</p> <p>2018-03-01</p> <p>iron deficiency anemia is a common and very relevant manifestation of inflammatory bowel disease (IBD). Although clinical practice guidelines have been published and updated on this subject, the management in the daily practice of this complication is far from optimal. to determine the actual management, needs and limitations of anemia in IBD by means of a survey of gastroenterology specialists. a self-administered telematic survey was carried out between April and May 2017 and was sent to SEPD members. The survey included four sections: participant demographics, monitoring, treatment and limitations/needs. a total of 122 evaluable surveys were received from all Spanish autonomous communities. Iron deficiency anemia is considered as a frequent manifestation of IBD and is monitored in all patients via the measurement of hemoglobin and ferritin. In the case of anemia, the survey respondents found it necessary to rule out the presence of IBD activity. However, only 14.8% prescribed intravenous iron when IBD was active. The required dose of intravenous iron is mainly calculated according to patient needs but only 33.1% of clinicians infused doses of 1 g or more. the "Gestiona <span class="hlt">Hierro</span> EII" survey on the management of anemia in IBD demonstrated a high quality of care, even though some aspects need to be improved. These included the prescription of intravenous iron for patients with disease activity, the use of high-dose intravenous iron and the implementation of algorithms into clinical practice.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27509186','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27509186"><span>Structural Insights into the <span class="hlt">Por</span>K and <span class="hlt">Por</span>N Components of the Porphyromonas gingivalis Type IX Secretion System.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Gorasia, Dhana G; Veith, Paul D; Hanssen, Eric G; Glew, Michelle D; Sato, Keiko; Yukitake, Hideharu; Nakayama, Koji; Reynolds, Eric C</p> <p>2016-08-01</p> <p>The type IX secretion system (T9SS) has been recently discovered and is specific to Bacteroidetes species. Porphyromonas gingivalis, a keystone pathogen for periodontitis, utilizes the T9SS to transport many proteins including the gingipain virulence factors across the outer membrane and attach them to the cell surface via a sortase-like mechanism. At least 11 proteins have been identified as components of the T9SS including <span class="hlt">Por</span>K, <span class="hlt">Por</span>L, <span class="hlt">Por</span>M, <span class="hlt">Por</span>N and <span class="hlt">Por</span>P, however the precise roles of most of these proteins have not been elucidated and the structural organization of these components is unknown. In this study, we purified <span class="hlt">Por</span>K and <span class="hlt">Por</span>N complexes from P. gingivalis and using electron microscopy we have shown that <span class="hlt">Por</span>N and the <span class="hlt">Por</span>K lipoprotein interact to form a 50 nm diameter ring-shaped structure containing approximately 32-36 subunits of each protein. The formation of these rings was dependent on both <span class="hlt">Por</span>K and <span class="hlt">Por</span>N, but was independent of <span class="hlt">Por</span>L, <span class="hlt">Por</span>M and <span class="hlt">Por</span>P. <span class="hlt">Por</span>L and <span class="hlt">Por</span>M were found to form a separate stable complex. <span class="hlt">Por</span>K and <span class="hlt">Por</span>N were protected from proteinase K cleavage when present in undisrupted cells, but were rapidly degraded when the cells were lysed, which together with bioinformatic analyses suggests that these proteins are exposed in the periplasm and anchored to the outer membrane via the <span class="hlt">Por</span>K lipid. Chemical cross-linking and mass spectrometry analyses confirmed the interaction between <span class="hlt">Por</span>K and <span class="hlt">Por</span>N and further revealed that they interact with the PG0189 outer membrane protein. Furthermore, we established that <span class="hlt">Por</span>N was required for the stable expression of <span class="hlt">Por</span>K, <span class="hlt">Por</span>L and <span class="hlt">Por</span>M. Collectively, these results suggest that the ring-shaped <span class="hlt">Por</span>K/N complex may form part of the secretion channel of the T9SS. This is the first report showing the structural organization of any T9SS component.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li class="active"><span>5</span></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_5 --> <div id="page_6" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li class="active"><span>6</span></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="101"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4980022','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4980022"><span>Structural Insights into the <span class="hlt">Por</span>K and <span class="hlt">Por</span>N Components of the Porphyromonas gingivalis Type IX Secretion System</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Gorasia, Dhana G.; Veith, Paul D.; Hanssen, Eric G.; Glew, Michelle D.; Sato, Keiko; Yukitake, Hideharu; Nakayama, Koji; Reynolds, Eric C.</p> <p>2016-01-01</p> <p>The type IX secretion system (T9SS) has been recently discovered and is specific to Bacteroidetes species. Porphyromonas gingivalis, a keystone pathogen for periodontitis, utilizes the T9SS to transport many proteins including the gingipain virulence factors across the outer membrane and attach them to the cell surface via a sortase-like mechanism. At least 11 proteins have been identified as components of the T9SS including <span class="hlt">Por</span>K, <span class="hlt">Por</span>L, <span class="hlt">Por</span>M, <span class="hlt">Por</span>N and <span class="hlt">Por</span>P, however the precise roles of most of these proteins have not been elucidated and the structural organization of these components is unknown. In this study, we purified <span class="hlt">Por</span>K and <span class="hlt">Por</span>N complexes from P. gingivalis and using electron microscopy we have shown that <span class="hlt">Por</span>N and the <span class="hlt">Por</span>K lipoprotein interact to form a 50 nm diameter ring-shaped structure containing approximately 32–36 subunits of each protein. The formation of these rings was dependent on both <span class="hlt">Por</span>K and <span class="hlt">Por</span>N, but was independent of <span class="hlt">Por</span>L, <span class="hlt">Por</span>M and <span class="hlt">Por</span>P. <span class="hlt">Por</span>L and <span class="hlt">Por</span>M were found to form a separate stable complex. <span class="hlt">Por</span>K and <span class="hlt">Por</span>N were protected from proteinase K cleavage when present in undisrupted cells, but were rapidly degraded when the cells were lysed, which together with bioinformatic analyses suggests that these proteins are exposed in the periplasm and anchored to the outer membrane via the <span class="hlt">Por</span>K lipid. Chemical cross-linking and mass spectrometry analyses confirmed the interaction between <span class="hlt">Por</span>K and <span class="hlt">Por</span>N and further revealed that they interact with the PG0189 outer membrane protein. Furthermore, we established that <span class="hlt">Por</span>N was required for the stable expression of <span class="hlt">Por</span>K, <span class="hlt">Por</span>L and <span class="hlt">Por</span>M. Collectively, these results suggest that the ring-shaped <span class="hlt">Por</span>K/N complex may form part of the secretion channel of the T9SS. This is the first report showing the structural organization of any T9SS component. PMID:27509186</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5005315','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5005315"><span>The <span class="hlt">Por</span>X Response Regulator of the Porphyromonas gingivalis <span class="hlt">Por</span>XY Two-Component System Does Not Directly Regulate the Type IX Secretion Genes but Binds the <span class="hlt">Por</span>L Subunit</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Vincent, Maxence S.; Durand, Eric; Cascales, Eric</p> <p>2016-01-01</p> <p>The Type IX secretion system (T9SS) is a versatile multi-protein complex restricted to bacteria of the Bacteriodetes phylum and responsible for the secretion or cell surface exposition of diverse proteins that participate to S-layer formation, gliding motility or pathogenesis. The T9SS is poorly characterized but a number of proteins involved in the assembly of the secretion apparatus in the oral pathogen Porphyromonas gingivalis have been identified based on genome substractive analyses. Among these proteins, <span class="hlt">Por</span>Y, and <span class="hlt">Por</span>X encode typical two-component system (TCS) sensor and CheY-like response regulator respectively. Although the <span class="hlt">por</span>X and <span class="hlt">por</span>Y genes do not localize at the same genetic locus, it has been proposed that <span class="hlt">Por</span>XY form a bona fide TCS. Deletion of <span class="hlt">por</span>X in P. gingivalis causes a slight decrease of the expression of a number of other T9SS genes, including sov, <span class="hlt">por</span>T, <span class="hlt">por</span>P, <span class="hlt">por</span>K, <span class="hlt">por</span>L, <span class="hlt">por</span>M, <span class="hlt">por</span>N, and <span class="hlt">por</span>Y. Here, we show that <span class="hlt">Por</span>X and the soluble cytoplasmic domain of <span class="hlt">Por</span>Y interact. Using electrophoretic mobility shift, DNA-protein co-purification and heterologous host expression assays, we demonstrate that <span class="hlt">Por</span>X does not bind T9SS gene promoters and does not directly regulate expression of the T9SS genes. Finally, we show that <span class="hlt">Por</span>X interacts with the cytoplasmic domain of <span class="hlt">Por</span>L, a component of the T9SS membrane core complex and propose that the CheY-like <span class="hlt">Por</span>X protein might be involved in the dynamics of the T9SS. PMID:27630829</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015AGUFM.V21C3046O','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015AGUFM.V21C3046O"><span>CO2-SO3-rich (carbonate-sulfate) melt/fluids in the lithosphere beneath El <span class="hlt">Hierro</span>, Canary Islands.</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Oglialoro, E.; Ferrando, S.; Malaspina, N.; Villa, I. M.; Frezzotti, M. L.</p> <p>2015-12-01</p> <p>Mantle xenoliths from the island of El <span class="hlt">Hierro</span>, the youngest of the Canary Islands, have been studied to characterize fluxes of carbon in the lithosphere of an OIB volcanism region. Fifteen xenoliths (4-10 cm in diameter) were collected in a rift lava flow (15-41 ka) at a new xenolith locality in El Julan cliff (S-SW of the island). Peridotites consist of protogranular to porphyroblastic spinel harzburgites, lherzolites, and subordinate dunites. One spinel clinopyroxenite, and one olivine-websterite were also analyzed. Ultramafic xenoliths were classified as HEXO (harzburgite and dunite with exsolved orthopyroxene), HLCO (harzburgite and lherzolite containing orthopyroxene without visible exsolution lamellae), and HTR (transitional harzburgite with exsolved orthopyroxene porphyroclasts, and poikilitic orthopyroxene) following [1]. While HLCO and HTR peridotites contain mostly CO2 fluid inclusions, HEXO peridotites preserve an early association of melt/fluid inclusions containing dominantly carbonate/sulfate/silicate glass, evolving to carbonate/sulfate/phosphate/spinel aggregates, with exsolved CO2 (± carbonates, anhydrite and H2O). Chemical and Raman analyses identify dolomite, Mg-calcite, anhydrite, sulfohalite [Na6(SO4)2FCl] (± other anhydrous and hydrous alkali-sulfates), apatite, and Cr-spinel in the inclusions. Sulfides are noticeably absent. The microstructure and chemical composition of the metasomatic fluids indicate that the peridotites were infiltrated by a carbonate-sulfate-silicate melt/fluid enriched in CO2, H2O, and P. A mantle origin for this fluid is supported by high densities of CO2inclusions (> 1g/cm3), determined by Raman microspectroscopy and cross-checked by microthermometry. Consequently, El Julan peridotites provide the first evidence for liberating oxidized C and S fluxes from the Earth lithosphere in an OIB source region, and suggest that oxidation of sulfide to sulfate can occur during small-degree partial melting of the upper mantle</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015Tectp.642...71T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015Tectp.642...71T"><span>Multifractal investigation of continuous seismic signal recorded at El <span class="hlt">Hierro</span> volcano (Canary Islands) during the 2011-2012 pre- and eruptive phases</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Telesca, Luciano; Lovallo, Michele; Martì Molist, Joan; López Moreno, Carmen; Abella Meléndez, Rafael</p> <p>2015-02-01</p> <p>The Multifractal Detrended Fluctuation Analysis (MF-DFA) is an effective method that allows detecting multifractality in non-stationary signals. We applied the MF-DFA to the continuous seismic signal recorded at El <span class="hlt">Hierro</span> volcano (Canary Islands), which was affected by a submarine monogenetic eruption in October 2011. We investigated the multifractal properties of the continuous seismic signal before the onset of the eruption and after. We analysed three frames of the signal, one measured before the onset of eruption that occurred on October 10, 2011; and two after, but corresponding to two distinct eruptive episodes, the second one started on November 22, 2011 and lasting until late February 2012. The results obtained show a striking difference in the width of the multifractal spectrum, which is generally used to quantify the multifractal degree of a signal: the multifractal spectra of the signal frames recorded during the eruptive episodes are almost identical and much narrower than that of the signal frame measured before the onset of the eruption. Such difference indicates that the seismic signal recorded during the unrest reflects mostly the fracturing of the host rock under the overpressure exerted by the intruding magma, while that corresponding to the eruptive phases was mostly influenced by the flow of magma through the plumbing system, even some fracturing remains, not being possible to distinguish among the two eruptive episodes in terms of rock fracture mechanics.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012EGUGA..1412251S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012EGUGA..1412251S"><span>Mafic intrusion remobilising silicic magma under El <span class="hlt">Hierro</span>, Canary Islands</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Sigmarsson, O.; Laporte, D.; Marti, J.; Devouard, B.; Cluzel, N.</p> <p>2012-04-01</p> <p>The 2011 submarine eruption at El <span class="hlt">Hierro</span>, Canary Islands, has produced volcanic bombs that degas at sea surface, boil seawater and sink when cooled and degassed. At the beginning of the eruption white coloured pumices enveloped in darker coloured spatters floated on land. These composite pumices show evidence of magma mingling with folds and undulations of the darker coloured magma within the white pumice suggesting magma mingling in a viscous regime. The white pumice is highly vesicular and resembles foam. Most of the vesicular structure is made of tightly packed, polygonal bubbles of uniform size (˜ 100 μm), suggesting a single event of homogeneous bubble nucleation. An earlier event of heterogeneous bubble nucleation is indicated by the presence of a few large bubbles developed around tiny quartz crystals. Both the darker and lighter coloured pumices are almost aphyric. A few olivine crystals with perfect euhedral morphology occur within the darker part. Rare olivines of same composition are also found in the white pumice glass but then display somewhat rounded outlines and hopper-type structure. Melt inclusions in olivines of the darker pumice are of the same composition as the enveloping mafic glass, whereas olivines in the mixing boundary layer have melt inclusions of less mafic composition. The whole-rock composition and slightly more evolved glass composition are of basanitc and alkali rhyolitic composition (at the limit of the trachyte field) according to the TAS classification. Such rhyolitic compositions are rare in the Canaries. Analyses of residual volatile concentration in the glasses show that the silicic glass is highly degassed (F: 511 ±222; Cl: 202 ±58; S: below detection limit; values in ppm,1SD, n=10), whereas the basanitic glass still has very high halogene concentrations (F: 1354 ±151; Cl: 1026 ±47; S: 362 ±29; 1SD, n=10). In-situ analysis of trace element compositions of the dark glasses reveal typical basanitic compositions with</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014AGUFM.T23C4692B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014AGUFM.T23C4692B"><span>Time-dependent deformation at elevated temperatures in basalt from El <span class="hlt">Hierro</span>, Stromboli and Teide volcanoes</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Benson, P. M.; Fahrner, D.; Harnett, C. E.; Fazio, M.</p> <p>2014-12-01</p> <p>Time dependent deformation describes the process whereby brittle materials deform at a stress level below their short-term material strength (Ss), but over an extended time frame. Although generally well understood in engineering (where it is known as static fatigue or "creep"), knowledge of how rocks creep and fail has wide ramifications in areas as diverse as mine tunnel supports and the long term stability of critically loaded rock slopes. A particular hazard relates to the instability of volcano flanks. A large number of flank collapses are known such as Stromboli (Aeolian islands), Teide, and El <span class="hlt">Hierro</span> (Canary Islands). Collapses on volcanic islands are especially complex as they necessarily involve the combination of active tectonics, heat, and fluids. Not only does the volcanic system generate stresses that reach close to the failure strength of the rocks involved, but when combined with active pore fluid the process of stress corrosion allows the rock mass to deform and creep at stresses far lower than Ss. Despite the obvious geological hazard that edifice failure poses, the phenomenon of creep in volcanic rocks at elevated temperatures has yet to be thoroughly investigated in a well controlled laboratory setting. We present new data using rocks taken from Stromboli, El Heirro and Teide volcanoes in order to better understand the interplay between the fundamental rock mechanics of these basalts and the effects of elevated temperature fluids (activating stress corrosion mechanisms). Experiments were conducted over short (30-60 minute) and long (8-10 hour) time scales. For this, we use the method of Heap et al., (2011) to impose a constant stress (creep) domain deformation monitored via non-contact axial displacement transducers. This is achieved via a conventional triaxial cell to impose shallow conditions of pressure (<25 MPa) and temperature (<200 °C), and equipped with a 3D laboratory seismicity array (known as acoustic emission, AE) to monitor the micro</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA345916','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA345916"><span>West Europe Report No. 2139</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>1983-05-09</p> <p>Ap-PDP, 2; UCD, 1. Santa Cruz de Tenerife. Voters: 438,618. Seats: 30 (Tenerife, 15; La Palma, 8; Gomera, 4 and <span class="hlt">Hierro</span> , 3). Deputies 28 October 1982...Canaries, have aroused the interest of independent groups that normally operate on the peripheral islands, such as Gomera and <span class="hlt">Hierro</span> . 113 During the...Independent Gomera Electoral Group: Esteban Bethencourt. <span class="hlt">Hierro</span> : PSOE: Jose Francisco Armas. AP-PDP-UL: Manuel Fernandez Gonzalez. PCE: Aurelio Ayala</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/AD1013937','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/AD1013937"><span>Population Parameters of Blainvilles and Cuviers Beaked Whales</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2015-09-30</p> <p>cetacean populations. Long-term monitoring of beaked whale populations in El <span class="hlt">Hierro</span> , a nearly pristine habitat far from areas of sonar testing or...marine industry, enables valuable studies of demographic trends and life history dictated mainly by natural parameters. El <span class="hlt">Hierro</span> is in process of...functioning (expected in 2018-2019), it is essential to continue monitoring the populations in El <span class="hlt">Hierro</span> to obtain an uninterrupted long-term dataset of</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA531335','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA531335"><span>Acoustic Detection, Behavior, and Habitat Use of Deep-Diving Odontocetes</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2009-09-30</p> <p>of El <span class="hlt">Hierro</span> , and short-finned pilot whales, Globicephela macrorynchus, off the island of Tenerife in the Canary Islands [Aguilar, 2006]). These...in El <span class="hlt">Hierro</span> (Oct. 2008). Key result was an 18 hour DTAG attachment to a Blainville’s beaked whale with contemporary acoustic recordings from a...drifting buoy. • Three 7-day seasonal surveys in El <span class="hlt">Hierro</span> . Methods included passive acoustic monitoring, photo- identification and double visual</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA482696','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA482696"><span>Measuring the Behavior and Response to Sound of Beaked Whales Using Recording Tags</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2004-01-01</p> <p>led by Alberto Brito of the University of La Laguna. His team of biology graduate students maintain a field station in the island of El <span class="hlt">Hierro</span> ...in the Canary Island field site of El <span class="hlt">Hierro</span> (Figs. 3, 4). In analyzing identification photos, the Italian group have confirmed sightings of several...specie. The exceptional sighting rate of both species in El <span class="hlt">Hierro</span> makes this one of the densest coastal populations of beaked whales known</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA578413','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA578413"><span>Population Parameters of Beaked Whales</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2012-09-30</p> <p>difficult to study. El <span class="hlt">Hierro</span> (Canary Islands) holds resident populations of Blainville’s and Cuvier’s beaked whales in deep waters close to the shore...Field work: We performed two seasonal photoID surveys off El <span class="hlt">Hierro</span> (May and July 2012) focused on the two resident ziphiid species in the waters of...gather ancillary oceanographic data of the waters off El <span class="hlt">Hierro</span> . We obtain measurements of temperature, salinity and nutrient concentration in order</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA606315','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA606315"><span>Acoustic Response and Detection of Marine Mammals Using an Advanced Digital Acoustic Recording Tag(Rev 3)</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2007-03-13</p> <p>Victor Gonzalez, University of La Laguna. Fieldwork was supported by University of La Laguna and Governments of El <span class="hlt">Hierro</span> and the Canary Islands...team in El <span class="hlt">Hierro</span> and the Field team in Liguria. Fieldwork support was provided by Universidad de La Laguna (ULL), BluWest, NATO Undersea Research...Center (NURC), and Governments of El <span class="hlt">Hierro</span> and the Canary Islands. Some of Peter Madsen’s work was supported by a Steno Fellowship from the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA480993','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA480993"><span>Acoustic Detection, Behavior, and Habitat Use of Deep-Diving Odontocetes</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2007-01-01</p> <p>Blainville’s beaked whale, Mesoplodon densirostris, and Cuvier’s beaked whale, Ziphius cavirostris, off the island of El <span class="hlt">Hierro</span> in the Canary Islands...vocalizations to compare with the buoy recordings. We will also continue a seasonal photo-identification study of the El <span class="hlt">Hierro</span> beaked whales to build... <span class="hlt">Hierro</span> ), and April 2008 (pilot whales in Tenerife). Due to the late arrival of funds, we opted for a short field season with beaked whales in</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA616471','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA616471"><span>Population Parameters of Blainville’s and Cuvier’s Beaked Whales</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2014-09-30</p> <p>waters, they are usually difficult to study. El <span class="hlt">Hierro</span> (Canary Islands) holds resident populations of Blainville’s and Cuvier’s beaked whales in...surveys off El <span class="hlt">Hierro</span> , according to plan. Four of these cruises took place since the last report in September 2013, summing 38 days of fieldwork performed...marks as to be individually recognizable. 3 Publication of results of the ONR funded cetacean research in El <span class="hlt">Hierro</span> in 2014 Peer reviewed</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012EGUGA..1410243S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012EGUGA..1410243S"><span>Crustal Deformation During the 2011 Volanic Crisis of El <span class="hlt">Hierro</span>, Canary Islands, Revealed by Continuous GPS Observation</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Sagiya, T.; Barrancos Martinez, J.; Calvo, D.; Padron, E.; Hernandez, G. H.; Hernández, P. A.; Perez Rodriguez, N.; Suárez, J. M. P.</p> <p>2012-04-01</p> <p>Seismo-volcnic activity of El <span class="hlt">Hierro</span> started in the middle of July of 2011 and resulted in the active submarine eruption after October 12 south off La Restinga, the southern tip of the island. We have been operating one continuous GPS site on the island since 2004. Responding to the activity, we quickly installed 5 more GPS sites. Including another site operated by the Canary Islands Cartograhical Service (GRAFCAN) for a cartographic purpose, we have been monitoring 7 GPS sites equipped with dual-frequency receivers. We present the result of our crustal deformation monitoring and the magmatic activity inferred from the deformation data. In accordance with the deformation pattern, we divide the volcanic activity in 2011 into 4 stages. The first stage is from the middle of July to middle of September, during which steady magmatic inflation is estimated at the center of the island. The inflated volume of the first stage is estimated to be about 1.3 X 107 m3 at the depth of about 5km. The second stage, which continued until the first submarine eruption on October 12, is characterized by the accelerated deformation due to the upward as well as southward migration of magma. Additional inflation of about 2.1 X 107 m3 occurred in the depth range of 1-2km. The third stage continued for about 3 weeks after the first submarine eruption. During this stage, submarine eruption continues while no significant surface deformation is observed. It is considered magma supply from a deeper magma chamber continued during this 3 weeks period. Therefore, the total inflation volume during the first two stages gives the minimum estimate for the total magma volume. Since the beginning of November 2011, many GPS sites started subsiding. However, this deflation pattern is quite different from those in the shallow inflation stages. Horizontal deformation during this 4th stage is not significant, implying that deflation is occurring below the moho.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012EGUGA..1412374M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012EGUGA..1412374M"><span>Assessing the vulnerability of the evacuation emergency plan: the case of the El <span class="hlt">Hierro</span>, Canary Island, Spain</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Marrero, J. M.; Garcia, A.; Llinares, A.; Lopez, P.; Ortinz, R.</p> <p>2012-04-01</p> <p>On July 17, 2011 an unrest was detected in the El <span class="hlt">Hierro</span> island. A serretian submarine eruption started on October 10th in the southern area of the island, two miles away from La Restinga village. The analysis and interpretation of seismic and deformation data show a large volume of intruded magma. These data also show a high probability of a new vent opening. One of the most complex volcanic hazard scenarios is a new open vent in the El Golfo Valley, in the north slope of the island, where more than 5,000 people live. In this area there are only two possible terrestrial evacuation routes: 1) HI-1 road NE direction, the fastest but most vulnerable one, very near a 1,000 meters height cliff and through a 2 km tunnel with a structural deficiency that had to be closed during high energy periods of seismic activity; and 2) HI-1 road SW direction, a mountain road with many curves, frequent small landslides and fog. The Emergency Plan of the island takes into account the entire evacuation of El Golfo Valley in case of eruption. This process will be carried out by means of an assisted evacuation. The evacuees will be transported to a temporally regrouping shelter outside the valley to organize the transport to Tenerife Island. Only those people who have a second residence or relatives outside the affected area will be able to remain in the island. The evacuation time estimated by authorities for the entire evacuation of El Golfo Valley is of about 4 hours. This is extremely low considering: the complexity of the area; the number of evacuees; the lack of preparedness by the population; and adverse weather conditions. To evaluate the Evacuation Plan vulnerability, a series of evacuation scenarios have been simulated: self-evacuation; assisted evacuation; both terrestrial evacuation routes. The warning time, the response time by the population and the evacuation time have been taken into account.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015Tectp.647...33B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015Tectp.647...33B"><span>Three-armed rifts or masked radial pattern of eruptive fissures? The intriguing case of El <span class="hlt">Hierro</span> volcano (Canary Islands)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Becerril, L.; Galindo, I.; Martí, J.; Gudmundsson, A.</p> <p>2015-04-01</p> <p>Using new surface structural data as well as subsurface structural data obtained from seventeen water galleries, we provide a comprehensive model of the volcano-tectonic evolution of El <span class="hlt">Hierro</span> (Canary Islands). We have identified, measured and analysed more than 1700 volcano-structural elements including vents, eruptive fissures, dykes and faults. The new data provide important information on the main structural patterns of the island and on its stress and strain fields, all of which are crucial for reliable hazard assessments. We conducted temporal and spatial analyses of the main structural elements, focusing on their relative age and association with the three main cycles in the construction of the island: the Tiñor Edifice, the El Golfo-Las Playas Edifice, and the Rift Volcanism. A radial strike distribution, which can be related to constructive episodes, is observed in the on-land structures. A similar strike distribution is seen in the submarine eruptive fissures, which are radial with respect to the centre of the island. However, the volcano-structural elements identified onshore and reflecting the entire volcano-tectonic evolution of the island also show a predominant NE-SW strike, which coincides with the main regional trend of the Canary archipelago as a whole. Two other dominant directions of structural elements, N-S and WNW-ESE, are evident from the establishment of the El Golfo-Las Playas edifice, during the second constructive cycle. We suggest that the radial-striking structures reflect comparatively uniform stress fields during the constructive episodes, mainly conditioned by the combination of overburden pressure, gravitational spreading, and magma-induced stresses in each of the volcanic edifices. By contrast, in the shallower parts of the edifice the NE-SW, N-S and WNW-ESE-striking structures reflect local stress fields related to the formation of mega-landslides and masking the general and regional radial patterns.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/2585023','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/2585023"><span>Prognostic factors in multiple myeloma: definition of risk groups in 410 previously untreated patients: a Grupo Argentino de Tratamiento de la Leucemia <span class="hlt">Aguda</span> study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Corrado, C; Santarelli, M T; Pavlovsky, S; Pizzolato, M</p> <p>1989-12-01</p> <p>Four hundred ten previously untreated multiple myeloma patients entered onto two consecutive Grupo Argentino de Tratamiento de la Leucemia <span class="hlt">Aguda</span> (GATLA) protocols were analyzed to identify significant prognostic factors influencing survival. The univariate analysis selected the following variables: performance status, renal function, percentage of bone marrow plasma cells at diagnosis, hemoglobin, and age. A multivariate analysis showed that performance status, renal function, percentage of bone marrow plasma cells, hemoglobin, and age were the best predictive variables for survival. A score was assigned to each patient according to these variables, which led to their classification in three groups: good, intermediate, and poor risk, with a probability of survival of 26% and 10% at 96 months, and 5% at 56 months, and median survival of 60, 37, and 14 months, respectively (P = .0000). In our patient population, this model proved to be superior to the Durie-Salmon staging system in defining prognostic risk groups, and separating patients with significantly different risks within each Durie-Salmon stage.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA533030','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA533030"><span>Acoustic Detection, Behavior, and Habitat Use of Deep-Diving Odontocetes</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2008-09-30</p> <p>Rev. 8-98) Prescribed by ANSI Std Z39-18 off the island of El <span class="hlt">Hierro</span> , and short-finned pilot whales, Globicephela macrorynchus, off the island of...El <span class="hlt">Hierro</span> focused on beaked whales. A field team of 8-10 people staffed a shore visual station and two small boats for a total of 47 at-sea days in...increases our holdings to 11 tags from El <span class="hlt">Hierro</span> on this little-known species. A 21’ observation vessel, made available to the program at no cost by the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29890096','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29890096"><span>Alvarado score in the diagnostic of pain in the right lower quadrant.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lada, Paul Eduardo</p> <p>2017-09-08</p> <p>Acute appendicitis neither suspected nor diagnosed could develop a perforation or otherwise it would take to removing of a normal appendix. Utilization of a clinical score system for aided diagnosis of this pathology and can reduce a negative appendicitis. National Clinicas Hospital. Córdoba. Argentina. Prospective and protocolized study. 594 patients were studied between October 2002 and December 2013. 312 males and 282 females their age average was 26.2 years. Alvarado score was realized in all patients when they entered. According clinic and second valoration with the score surgical exploration was decided in 574 patients. The remaining 20 were excluded due to other pathology. The diagnosis in acute appendicitis was confirmed by surgical finding and histopathologic studies. In surgical finding we showed 594 patients (91,28 %) had acute appendicitis. There was no operative mortality. Respects morbidity there was 1,74 % of medical and 13,93 % of surgical complications. The anatomo-pathologic report showed a normal cecal appendix in 50. The incidence of negative appendicectomy was about 8.71 %. The utilization of score related to the surgical and anatomo-pathologic finding confirmed it was appreciable from 6 points to acute appendicitis diagnosis.   RESUMENAntecedentes: La apendicitis <span class="hlt">aguda</span> no sospechada y diagnosticada puede evolucionar hacia la perforación, ó <span class="hlt">por</span> el contrario conduce a la remoción de un apéndice normal. Objetivo: La utilización de un  sistema  de Score, desde un  punto de vista clínico, para el diagnóstico de esta patología y lograr disminuir las apendicetomías negativas.Lugar de Aplicación: Hospital Nacional de Clínicas. Córdoba. (Argentina)Diseño: Estudio prospectivo y protocolizado.Material y Métodos: Comprende a 594 pacientes estudiados entre octubre de 2002 y diciembre del 2013. De ellos, 312 eran del sexo masculino y 282 del femenino, con una edad promedio de 26,2 años de edad. A todos los pacientes se les realizo al</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li class="active"><span>6</span></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_6 --> <div id="page_7" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li class="active"><span>7</span></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="121"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014EGUGA..1614269S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014EGUGA..1614269S"><span>Probabilistic approach to decision making under uncertainty during volcanic crises. Retrospective analysis of the 2011 eruption of El <span class="hlt">Hierro</span>, in the Canary Islands</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Sobradelo, Rosa; Martí, Joan; Kilburn, Christopher; López, Carmen</p> <p>2014-05-01</p> <p>Understanding the potential evolution of a volcanic crisis is crucial to improving the design of effective mitigation strategies. This is especially the case for volcanoes close to densely-populated regions, where inappropriate decisions may trigger widespread loss of life, economic disruption and public distress. An outstanding goal for improving the management of volcanic crises, therefore, is to develop objective, real-time methodologies for evaluating how an emergency will develop and how scientists communicate with decision makers. Here we present a new model BADEMO (Bayesian Decision Model) that applies a general and flexible, probabilistic approach to managing volcanic crises. The model combines the hazard and risk factors that decision makers need for a holistic analysis of a volcanic crisis. These factors include eruption scenarios and their probabilities of occurrence, the vulnerability of populations and their activities, and the costs of false alarms and failed forecasts. The model can be implemented before an emergency, to identify actions for reducing the vulnerability of a district; during an emergency, to identify the optimum mitigating actions and how these may change as new information is obtained; and after an emergency, to assess the effectiveness of a mitigating response and, from the results, to improve strategies before another crisis occurs. As illustrated by a retrospective analysis of the 2011 eruption of El <span class="hlt">Hierro</span>, in the Canary Islands, BADEMO provides the basis for quantifying the uncertainty associated with each recommended action as an emergency evolves, and serves as a mechanism for improving communications between scientists and decision makers.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA531853','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA531853"><span>Development and Validation of a Mobile, Autonomous, Broadband Passive Acoustic Monitoring System for Marine Mammals</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2009-09-30</p> <p>will take place off the island of El <span class="hlt">Hierro</span> in the Canary Islands, a site with coastal resident populations of Blainville’s beaked whale, Mesoplodon...whales off El <span class="hlt">Hierro</span> , Canary Islands” European Research on Cetaceans 22nd, Holland, April, 2008. [non-refereed] Beedholm K., Madsen P., Johnson M</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA598752','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA598752"><span>Development and Validation of a Mobile, Autonomous, Broadband Passive Acoustic Monitoring System for Marine Mammals</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2011-09-30</p> <p>For beaked whales, field testing will take place off the island of El <span class="hlt">Hierro</span> in the Canary Islands, a site with coastal resident populations of...beaked whales off El <span class="hlt">Hierro</span> , Canary Islands,” European Research on Cetaceans 22nd. Holland, April, 2008. Baumgartner, M. F., and S. E. Mussoline</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23075153','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23075153"><span>Identification of Porphyromonas gingivalis proteins secreted by the <span class="hlt">Por</span> secretion system.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sato, Keiko; Yukitake, Hideharu; Narita, Yuka; Shoji, Mikio; Naito, Mariko; Nakayama, Koji</p> <p>2013-01-01</p> <p>The Gram-negative bacterium Porphyromonas gingivalis possesses a number of potential virulence factors for periodontopathogenicity. In particular, cysteine proteinases named gingipains are of interest given their abilities to degrade host proteins and process other virulence factors such as fimbriae. Gingipains are translocated on the cell surface or into the extracellular milieu by the <span class="hlt">Por</span> secretion system (<span class="hlt">Por</span>SS), which consists of a number of membrane or periplasmic proteins including <span class="hlt">Por</span>K, <span class="hlt">Por</span>L, <span class="hlt">Por</span>M, <span class="hlt">Por</span>N, <span class="hlt">Por</span>O, <span class="hlt">Por</span>P, <span class="hlt">Por</span>Q, <span class="hlt">Por</span>T, <span class="hlt">Por</span>U, <span class="hlt">Por</span>V (PG27, LptO), <span class="hlt">Por</span>W and Sov. To identify proteins other than gingipains secreted by the <span class="hlt">Por</span>SS, we compared the proteomes of P. gingivalis strains kgp rgpA rgpB (<span class="hlt">Por</span>SS-proficient strain) and kgp rgpA rgpB <span class="hlt">por</span>K (<span class="hlt">Por</span>SS-deficient strain) using two-dimensional gel electrophoresis and peptide-mass fingerprinting. Sixteen spots representing 10 different proteins were present in the particle-free culture supernatant of the <span class="hlt">Por</span>SS-proficient strain but were absent or faint in that of the <span class="hlt">Por</span>SS-deficient strain. These identified proteins possessed the C-terminal domains (CTDs), which had been suggested to form the CTD protein family. These results indicate that the <span class="hlt">Por</span>SS is used for secretion of a number of proteins other than gingipains and that the CTDs of the proteins are associated with the <span class="hlt">Por</span>SS-dependent secretion. © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA374015','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA374015"><span>Translations on Latin America, Number 1657</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>1977-06-01</p> <p>Text] The 17th of last March, Industria del <span class="hlt">Hierro</span> , S.A. [Iron Industries] delivered through its mechanical division-8 land rigs for drilling...design of this equipment allows it to be re-installed in only 3 days. Industria del <span class="hlt">Hierro</span> was established in the city of Queretaro in 1963, with</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA495629','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA495629"><span>Bioavailability of Allelochemicals in Soil</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2008-02-27</p> <p>knapweed species has been noted (Goslee et at., 2001; Grant et al., 2003; <span class="hlt">Hierro</span> and Callaway, 2003). Yet, very little is known about the sorption of...Environmental Science & Technology 31:321-326. <span class="hlt">Hierro</span> , J.L., and R.M. Callaway. 2003. Allelopathy and exotic plant invasion. Plant and Soil 256:29-39</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA441195','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA441195"><span>Development and Field testing of the DTAG for Deep-Diving Odontocetes</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2005-01-12</p> <p>34Resident and reproductive populations of beaked whales in El <span class="hlt">Hierro</span> , Canary Islands", European Research on Cetaceans 19th, France, April 2005. Aguilar... <span class="hlt">Hierro</span> (Canary Islands)", European Research on Cetaceans 18th, Sweden, 2004. Tregenza N.J.C., Johnson M., Aguilar de Soto N., "Automated detection of</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3100902','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3100902"><span>Suppression of Cytochrome P450 Reductase (<span class="hlt">POR</span>) Expression in Hepatoma Cells Replicates the Hepatic Lipidosis Observed in Hepatic <span class="hlt">POR</span>-Null Mice</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Banerjee, Subhashis; Stolarczyk, Elzbieta I.; Zou, Ling</p> <p>2011-01-01</p> <p>Cytochrome P450 reductase (<span class="hlt">POR</span>) is a microsomal electron transport protein essential to cytochrome P450-mediated drug metabolism and sterol and bile acid synthesis. The conditional deletion of hepatic <span class="hlt">POR</span> gene expression in mice results in a marked decrease in plasma cholesterol levels counterbalanced by the accumulation of triglycerides in lipid droplets in hepatocytes. To evaluate the role of cholesterol and bile acid synthesis in this hepatic lipidosis, as well as the possible role of lipid transport from peripheral tissues, we developed a stable, small interfering RNA (siRNA)-mediated cell culture model for the suppression of <span class="hlt">POR</span>. <span class="hlt">POR</span> mRNA and protein expression were decreased by greater than 50% in McArdle-RH7777 rat hepatoma cells 10 days after transfection with a <span class="hlt">POR</span>-siRNA expression plasmid, and <span class="hlt">POR</span> expression was nearly completely extinguished by day 20. Immunofluorescent analysis revealed a marked accumulation of lipid droplets in cells by day 15, accompanied by a nearly 2-fold increase in cellular triglyceride content, replicating the lipidosis seen in hepatic <span class="hlt">POR</span>-null mouse liver. In contrast, suppression of CYP51A1 (lanosterol demethylase) did not result in lipid accumulation, indicating that loss of cholesterol synthesis is not the basis for this lipidosis. Indeed, addition of cholesterol to the medium appeared to augment the lipidosis in <span class="hlt">POR</span>-suppressed cells, whereas removal of lipids from the medium reversed the lipidosis. Oxysterols did not accumulate in <span class="hlt">POR</span>-suppressed cells, discounting a role for liver X receptor in stimulating triglyceride synthesis, but addition of chenodeoxycholate significantly repressed lipid accumulation, suggesting that the absence of bile acids and loss of farnesoid X receptor stimulation lead to excessive triglyceride synthesis. PMID:21368239</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21368239','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21368239"><span>Suppression of cytochrome P450 reductase (<span class="hlt">POR</span>) expression in hepatoma cells replicates the hepatic lipidosis observed in hepatic <span class="hlt">POR</span>-null mice.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Porter, Todd D; Banerjee, Subhashis; Stolarczyk, Elzbieta I; Zou, Ling</p> <p>2011-06-01</p> <p>Cytochrome P450 reductase (<span class="hlt">POR</span>) is a microsomal electron transport protein essential to cytochrome P450-mediated drug metabolism and sterol and bile acid synthesis. The conditional deletion of hepatic <span class="hlt">POR</span> gene expression in mice results in a marked decrease in plasma cholesterol levels counterbalanced by the accumulation of triglycerides in lipid droplets in hepatocytes. To evaluate the role of cholesterol and bile acid synthesis in this hepatic lipidosis, as well as the possible role of lipid transport from peripheral tissues, we developed a stable, small interfering RNA (siRNA)-mediated cell culture model for the suppression of <span class="hlt">POR</span>. <span class="hlt">POR</span> mRNA and protein expression were decreased by greater than 50% in McArdle-RH7777 rat hepatoma cells 10 days after transfection with a <span class="hlt">POR</span>-siRNA expression plasmid, and <span class="hlt">POR</span> expression was nearly completely extinguished by day 20. Immunofluorescent analysis revealed a marked accumulation of lipid droplets in cells by day 15, accompanied by a nearly 2-fold increase in cellular triglyceride content, replicating the lipidosis seen in hepatic <span class="hlt">POR</span>-null mouse liver. In contrast, suppression of CYP51A1 (lanosterol demethylase) did not result in lipid accumulation, indicating that loss of cholesterol synthesis is not the basis for this lipidosis. Indeed, addition of cholesterol to the medium appeared to augment the lipidosis in <span class="hlt">POR</span>-suppressed cells, whereas removal of lipids from the medium reversed the lipidosis. Oxysterols did not accumulate in <span class="hlt">POR</span>-suppressed cells, discounting a role for liver X receptor in stimulating triglyceride synthesis, but addition of chenodeoxycholate significantly repressed lipid accumulation, suggesting that the absence of bile acids and loss of farnesoid X receptor stimulation lead to excessive triglyceride synthesis.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012EGUGA..14.6092S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012EGUGA..14.6092S"><span>Volcanic hazard assessment for the Canary Islands (Spain) using extreme value theory, and the recent volcanic eruption of El <span class="hlt">Hierro</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Sobradelo, R.; Martí, J.; Mendoza-Rosas, A. T.; Gómez, G.</p> <p>2012-04-01</p> <p>The Canary Islands are an active volcanic region densely populated and visited by several millions of tourists every year. Nearly twenty eruptions have been reported through written chronicles in the last 600 years, suggesting that the probability of a new eruption in the near future is far from zero. This shows the importance of assessing and monitoring the volcanic hazard of the region in order to reduce and manage its potential volcanic risk, and ultimately contribute to the design of appropriate preparedness plans. Hence, the probabilistic analysis of the volcanic eruption time series for the Canary Islands is an essential step for the assessment of volcanic hazard and risk in the area. Such a series describes complex processes involving different types of eruptions over different time scales. Here we propose a statistical method for calculating the probabilities of future eruptions which is most appropriate given the nature of the documented historical eruptive data. We first characterise the eruptions by their magnitudes, and then carry out a preliminary analysis of the data to establish the requirements for the statistical method. Past studies in eruptive time series used conventional statistics and treated the series as an homogeneous process. In this paper, we will use a method that accounts for the time-dependence of the series and includes rare or extreme events, in the form of few data of large eruptions, since these data require special methods of analysis. Hence, we will use a statistical method from extreme value theory. In particular, we will apply a non-homogeneous Poisson process to the historical eruptive data of the Canary Islands to estimate the probability of having at least one volcanic event of a magnitude greater than one in the upcoming years. Shortly after the publication of this method an eruption in the island of El <span class="hlt">Hierro</span> took place for the first time in historical times, supporting our method and contributing towards the validation of</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA551851','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA551851"><span>Reliability-Limiting Defects in GaN/AlGaN High Electron Mobility Transistors</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2011-12-01</p> <p>GaN grown by plasma-assisted molecular beam epitaxy”, Appl. Phys. Lett., vol. 77, no. 18, pp. 2885- 2887, 2000. [24] A. <span class="hlt">Hierro</span> , A. R. Arehart, B...defects and impurities: Applications to III-nitrides”, J. Appl. Phys., vol. 95, pp.3851-3879, 2004. [43] A. <span class="hlt">Hierro</span> , S. A. Ringel, M. Hansen, J. S</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA541592','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA541592"><span>Development and Validation of a Mobile, Autonomous, Broadband Passive Acoustic Monitoring System for Marine Mammals</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2010-09-30</p> <p>after each trial. For beaked whales, field testing will take place off the island of El <span class="hlt">Hierro</span> in the Canary Islands, a site with coastal resident...Johnson, M., “Coastal habitat use by Cuvier´s and Blainville´s beaked whales off El <span class="hlt">Hierro</span> , Canary Islands” European Research on Cetaceans 22nd</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA482208','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA482208"><span>Current Collapse Induced in AlGaN/GaN High-Electron-Mobility Transistors by Bias Stress</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2003-08-25</p> <p>structure where the traps causing current collapse can be passivated by forming H-defect complexes. <span class="hlt">Hierro</span> et al.7 have shown, for example, that deep...Lett. 75, 4016 ~1999!. 7 A. <span class="hlt">Hierro</span> , S. A. Ringel, M. Hansen, J. S. Speck, U. K. Mishra, and S. P. DenBaars, Appl. Phys. Lett. 77, 1499 ~2000!. 8 S. J</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA533837','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA533837"><span>Development and Validation of a Mobile, Autonomous, Broadband Passive Acoustic Monitoring System for Marine Mammals</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2008-09-30</p> <p>take place off the island of El <span class="hlt">Hierro</span> in the Canary Islands, a site with coastal resident populations of Blainville’s beaked whale, Mesoplodon...M., “Coastal habitat use by Cuvier´s and Blainville´s beaked whales off El <span class="hlt">Hierro</span> , Canary Islands” European Research on Cetaceans 22nd, Holland, April, 2008. [non-refereed] 5</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA602460','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA602460"><span>Laterally-Biased Quantum IR Detectors</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2013-10-23</p> <p>Rocío San-Román, Adrián <span class="hlt">Hierro</span> , Journal of Crystal Growth 323, (2011), 496-500. [3] Semiconductor Devices: Physics and Technology 2nd Ed., S.M. Sze...6] “Laterally biased double quantum well IR detector fabricated by MBE regrowth”, Álvaro Guzmán, Rocío San-Román, Adrián <span class="hlt">Hierro</span> , 16th</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA534545','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA534545"><span>Collaborative Research and Development (CR&D). Task Order 0036: Physical and Chemical Processes of Operating Electronic Devices</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2006-09-01</p> <p>actually seen. A. <span class="hlt">Hierro</span> , … S. A. Ringel et al., Phys. Stat. Sol (b) 228, 937 (2001). Ohio State U. Use DLTS and DLOS (Deep Level Optical Spectroscopy...to threading dislocations. Also see A. <span class="hlt">Hierro</span> et al., APL 76, 3064 (2000), where traps at EC-ET=0.58-0.62, 1.35, 2.57-2.64, 3.22eV are seen in GaN</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27238780','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27238780"><span>[In Process Citation].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wang, Bingsong; Li, Yijun; Wu, Xiaolu; Liu, Qingqing; Tang, Xue; Wang, Zuo</p> <p>2016-03-25</p> <p>Objetivos: oligoelementos como zinc (Zn), <span class="hlt">hierro</span> (Fe) y cobre (Cu) tienen una influencia significativa en el mantenimiento de la función inmune y del metabolismo normales; modulan la función immune e influyen en la susceptibilidad del organismo ante infecciones. Pero la relación entre trazas de estos elementos y la bronconeumonía resultó incierta. Métodos: en este estudio fueron incluidos 28 niños con bronconeumonía y 46 niños sanos agrupados <span class="hlt">por</span> edad. Se determinaron los niveles de Zn, Cu, Fe, calcio (Ca) y/o magnesio (Mg) en el suero de los niños con bronconeumonía y sin ella mediante espectrofotometría de absorción atómica. Resultados: los resultados muestran que varios niveles de microelementos como Zn, Ca, Mg y Fe en el grupo con bronconeumonía son menores que en el grupo control. En el grupo de niños con bronconeumonía el nivel de Ca en el suero está asociado positivamente con el zinc (Zn) (p < 0,05) y el <span class="hlt">hierro</span> (Fe) (p < 0,05), mientras que hay una correlación positiva entre el cobre (Cu) y el calcio (Ca) (p < 0,05), magnesio (mg) (p < 0,05). Conclusión: el nivel de oligoelemento en el suero puede estar asociado con el riesgo de bronconeumonía entre los niños.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014E%26PSL.403..456O','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014E%26PSL.403..456O"><span>Comment on “Identification of the subsurface sulfide bodies responsible for acidity in Río Tinto source water, Spain” by Gómez-Ortiz et al. (Earth Planet. Sci. Lett. 391 (2014) 36-41)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Olías, Manuel; Nieto, José Miguel</p> <p>2014-10-01</p> <p>The source of the Río Tinto (SW Spain) is currently located close to the Peña de <span class="hlt">Hierro</span> mine, where it receives the first acidic waters. A few kilometers south, the river crosses the Río Tinto mines, a supergiant massive sulfide deposit that is much more important than those of Peña de <span class="hlt">Hierro</span>, and the acid pollutant contributions to the river increase by orders of magnitude.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/10148579','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/10148579"><span>System design description for portable 1,000 CFM exhauster Skids <span class="hlt">POR</span>-007/Skid E and <span class="hlt">POR</span>-008/Skid F</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Nelson, O.D.</p> <p>1998-07-25</p> <p>The primary purpose of the two 1,000 CFM Exhauster Skids, <span class="hlt">POR</span>-007-SKID E and <span class="hlt">POR</span>-008-SKID F, is to provide backup to the waste tank primary ventilation systems for tanks 241-C-106 and 241-AY-102, and the AY-102 annulus in the event of a failure during the sluicing of tank 241-C-106 and subsequent transfer of sluiced waste to 241-AY-102. This redundancy is required since both of the tank ventilation systems have been declared as Safety Class systems.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://images.nasa.gov/#/details-GSFC_20171208_Archive_e001276.html','SCIGOVIMAGE-NASA'); return false;" href="https://images.nasa.gov/#/details-GSFC_20171208_Archive_e001276.html"><span>Canary Islands</span></a></p> <p><a target="_blank" href="https://images.nasa.gov/">NASA Image and Video Library</a></p> <p></p> <p>2013-12-30</p> <p>On December 10, 2013 the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard NASA’s Terra satellite flew across the central Atlantic Ocean and captured a true-color image of the Canary Islands. Lying off of the coast of Western Sahara and Morocco, the islands were created by successive submarine volcanic eruptions which raised the ocean floor vertically until some of land rose above sea level. The oldest islands lie in the east and the youngest in the west. From east to west, the major islands seen in this image are: Lanzarote, Fuerteventura, Gran Canaria, Tenerife, La Gomera, La Palmera and El <span class="hlt">Hierro</span>. While the creation of the islands began in the Late Cretaceous Period (70 – 80 million years ago), active volcanic activity continues. In 2011, a spectacular submarine eruption occurred just off the shore of El <span class="hlt">Hierro</span>. The volcano became quiet again, but very recently increasing earthquakes and changing height of El <span class="hlt">Hierro</span> suggested the volcano may again be entering an active eruptive phase. On December 27 the island’s volcano monitoring agency had raised the volcanic eruption risk for El <span class="hlt">Hierro</span> to “yellow” – a code that means increasing activity but no eruption imminent. That afternoon a magnitude 5.1 earthquake struck offshore at El <span class="hlt">Hierro</span>. The epicenter was 9 miles (15 km) deep, and it was one of the largest quakes ever recorded at the island. Credit: NASA/GSFC/Jeff Schmaltz/MODIS Land Rapid Response Team NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. 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G.; Benavent, M.; Vélez, E. J.</p> <p>2012-04-01</p> <p>El <span class="hlt">Hierro</span> is an ocean island located at the western end of the Canary Islands, and along with Tenerife and La Palma islands have been the most geologically active in the recent past. The island has a triple armed rift and, presently, is at the stage of growth, representing the summit of a volcanic shield elevating from the seafloor at depth of 4000 m up to 1501 m above the sea level (Münn et al., 2006; Carracedo et al., 1999). Since July 19th, 2011 seismic activity has produced more than 11950 events up to date. The seismic crisis resulted in a volcanic eruption that began on October 10th, being still currently active. The new volcano is located 2 km off the coast and about 300 m depth, in the submarine flank of the southern rift of the island, which is extended some 40 km length. Since September 2004 until November 2010 two continuous tilt stations were installed at the north, Balneario site (BA), and at the center of the island, Aula de la Naturaleza (AU) site. Both stations were used to assess the pattern of local ground movements in the island. When seismic swarm started on past July 2011, we have reinstalled both tilt stations (BA and AU) and 2 new ones located at the south of the island, namely Montaña Quemada (MQ) and Restinga (RE) sites. We have used short base platform tiltmeters that measure ground tilts with resolutions varying from 0.1 up to 0.01 microradians (µrad). On October 8th, a 4.4 magnitude earthquake took place and is supposed that fractured the ocean crust at some 8-10 km off the south coast of the island and about 1000 m depth. Typical spike signals were observed at the tilt stations. Two days after, the eruption onset was recorded also at tilt stations through a remarkable increase of the high frequency signal, being of large amplitude the components (radial) orientated towards the new volcano edifice. When compared with previous tiltmeter records in the island, tilt pattern were clearly modified several times at the stations when strong</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014EGUGA..1615418M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014EGUGA..1615418M"><span>A new approach to the unrest and subsequent eruption at El <span class="hlt">Hierro</span> Island (2011) based on petrological, seismological, geodetical and gravimetric data</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Meletlidis, Stavros; Di Roberto, Alessio; Domínguez Cerdeña, Itahiza; Pompilio, Massimo; García-Cañada, Laura; Bertagnini, Antonella; Benito Saz, Maria Angeles; Del Carlo, Paola; Sainz-Maza Aparicio, Sergio; Lopez Moreno, Carmen; Moure García, David</p> <p>2014-05-01</p> <p>A shallow submarine eruption took place on 10th October 2011, about 1.8 km off the coast of La Restinga, a small village located in El <span class="hlt">Hierro</span> (Canary Islands, Spain). The eruption lasted for about four months and ended by early March 2012. The eruption was preceded by an unrest episode that initiated about three months before, in July 2011, and characterized by more than 10,000 localized earthquakes accompanied by up to 5 cm of vertical ground deformation. In the Canary Islands, this event represents the first case of an eruption that was monitored since the unrest to the end by the monitoring network of IGN (Instituto Geográfico National), providing a huge dataset that includes geophysical (seismic, magnetic and gravimetric), geodetic, geochemistry and petrological data. In this work we use the seismic, GPS and gravity records collected by IGN along with the petrological data derived from the study of various lava balloons, scoriaceous fragments and ash.Geophysical and geochemical monitoring tools provide a variety of information that need to be interpreted in terms of magma movement and/or interaction of magma with host rocks. We present a model, based on this data, which describes the intrusion and ascent of the magma. According to this model, a major intrusion beneath and around preexisting high-density magmatic bodies, localized in the central sector of the island, led to an eruption in the Southern sector of the island. After a failed attempt to reach the surface, while various dykes were emplaced, through a low fractured area in the Central and Northern parts of the island, the ascending magma finally found its way in the submarine area of La Restinga, in the South rift zone, at a depth of 350 m below sea level. Feeding of the eruption was achieved by the ascension of an important volume of material from the upper mantle which was emplaced near the crust-mantle boundary. However, the very energetic post-eruptive unrests - we had five episodes up today with</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27759788','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27759788"><span>UNDERSTANDING THE INTERNATIONAL CONSENSUS FOR ACUTE PANCREATITIS: CLASSIFICATION OF ATLANTA 2012.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Souza, Gleim Dias de; Souza, Luciana Rodrigues Queiroz; Cuenca, Ronaldo Máfia; Jerônimo, Bárbara Stephane de Medeiros; Souza, Guilherme Medeiros de; Vilela, Vinícius Martins</p> <p>2016-01-01</p> <p> morfologia pancreática e peripancreática. O entendimento dos diversos subtipos da doença e identificação de suas possíveis complicações requer familiaridade com a terminologia padrão, a qual permite comunicação efetiva entre os diversos membros da equipe multidisciplinar. Demonstrar terminologia e os parâmetros para identificação das diferentes classificações da doença a partir do consenso internacional para as pancreatites <span class="hlt">agudas</span> (Classificação de Atlanta 2012. Busca e análise de artigos no "Portal de Periódicos da CAPES" com descritores "pancreatite <span class="hlt">aguda</span>" e "Revisão de Atlanta". : Foram selecionados 23 artigos que continham descrições radiológicas, manejo ou dados estatísticos relacionados à doença. Dados estatísticos adicionais foram obtidos no sistema Datasus e Censo Demográfico 2010. O critério de diagnóstico radiológico adotado foi o do Colégio Americano de Radiologia. A "Classificação da pancreatite <span class="hlt">aguda</span> - 2012: revisão da classificação de Atlanta e definições <span class="hlt">por</span> consenso internacional" tenta eliminar a inconsistência e divergências a partir da determinação de uniformidade para os achados radiológicos, em especial à terminologia relacionada às coleções de fluidos. Termos mais abrangentes como "abscesso pancreático" e "flegmão" entraram em desuso e a evolução da coleção de fluidos pode ser descrita como: "coleções peripancreáticas <span class="hlt">agudas</span>", "coleções necróticas <span class="hlt">agudas</span>", "pseudocisto" e "necrose pancreática murada ou isolada". A tomografia computadorizada e a ressonância magnética representam as melhores técnicas com cortes sequenciais disponíveis para diagnóstico. A adequação da terminologia é ponto crítico e deve permitir o manejo do paciente <span class="hlt">por</span> múltiplos profissionais, estratificação de risco e adequação de tratamento.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5877877','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5877877"><span>Outer membrane vesicles from Neisseria gonorrhoeae target <span class="hlt">Por</span>B to mitochondria and induce apoptosis</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Elgass, Kirstin D.; Gabriel, Kipros; Dougan, Gordon; Lithgow, Trevor; Heinz, Eva</p> <p>2018-01-01</p> <p>Neisseria gonorrhoeae causes the sexually transmitted disease gonorrhoea by evading innate immunity. Colonizing the mucosa of the reproductive tract depends on the bacterial outer membrane porin, <span class="hlt">Por</span>B, which is essential for ion and nutrient uptake. <span class="hlt">Por</span>B is also targeted to host mitochondria and regulates apoptosis pathways to promote infections. How <span class="hlt">Por</span>B traffics from the outer membrane of N. gonorrhoeae to mitochondria and whether it modulates innate immune cells, such as macrophages, remains unclear. Here, we show that N. gonorrhoeae secretes <span class="hlt">Por</span>B via outer membrane vesicles (OMVs). Purified OMVs contained primarily outer membrane proteins including oligomeric <span class="hlt">Por</span>B. The porin was targeted to mitochondria of macrophages after exposure to purified OMVs and wild type N. gonorrhoeae. This was associated with loss of mitochondrial membrane potential, release of cytochrome c, activation of apoptotic caspases and cell death in a time-dependent manner. Consistent with this, OMV-induced macrophage death was prevented with the pan-caspase inhibitor, Q-VD-PH. This shows that N. gonorrhoeae utilizes OMVs to target <span class="hlt">Por</span>B to mitochondria and to induce apoptosis in macrophages, thus affecting innate immunity. PMID:29601598</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3553832','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3553832"><span>Gliding Motility and <span class="hlt">Por</span> Secretion System Genes Are Widespread among Members of the Phylum Bacteroidetes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Zhu, Yongtao</p> <p>2013-01-01</p> <p>The phylum Bacteroidetes is large and diverse, with rapid gliding motility and the ability to digest macromolecules associated with many genera and species. Recently, a novel protein secretion system, the <span class="hlt">Por</span> secretion system (<span class="hlt">Por</span>SS), was identified in two members of the phylum, the gliding bacterium Flavobacterium johnsoniae and the nonmotile oral pathogen Porphyromonas gingivalis. The components of the <span class="hlt">Por</span>SS are not similar in sequence to those of other well-studied bacterial secretion systems. The F. johnsoniae <span class="hlt">Por</span>SS genes are a subset of the gliding motility genes, suggesting a role for the secretion system in motility. The F. johnsoniae <span class="hlt">Por</span>SS is needed for assembly of the gliding motility apparatus and for secretion of a chitinase, and the P. gingivalis <span class="hlt">Por</span>SS is involved in secretion of gingipain protease virulence factors. Comparative analysis of 37 genomes of members of the phylum Bacteroidetes revealed the widespread occurrence of gliding motility genes and <span class="hlt">Por</span>SS genes. Genes associated with other bacterial protein secretion systems were less common. The results suggest that gliding motility is more common than previously reported. Microscopic observations confirmed that organisms previously described as nonmotile, including Croceibacter atlanticus, “Gramella forsetii,” Paludibacter propionicigenes, Riemerella anatipestifer, and Robiginitalea biformata, exhibit gliding motility. Three genes (gldA, gldF, and gldG) that encode an apparent ATP-binding cassette transporter required for F. johnsoniae gliding were absent from two related gliding bacteria, suggesting that the transporter may not be central to gliding motility. PMID:23123910</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/11994474','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/11994474"><span>Antigenic topology of chlamydial <span class="hlt">Por</span>B protein and identification of targets for immune neutralization of infectivity.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kawa, Diane E; Stephens, Richard S</p> <p>2002-05-15</p> <p>The outer membrane protein <span class="hlt">Por</span>B is a conserved chlamydial protein that functions as a porin and is capable of eliciting neutralizing Abs. A topological antigenic map was developed using overlapping synthetic peptides representing the Chlamydia trachomatis <span class="hlt">Por</span>B sequence and polyclonal immune sera. To identify which antigenic determinants were surface accessible, monospecific antisera were raised to the <span class="hlt">Por</span>B peptides and were used in dot-blot and ELISA-based absorption studies with viable chlamydial elementary bodies (EBs). The ability of the surface-accessible antigenic determinants to direct neutralizing Ab responses was investigated using standardized in vitro neutralization assays. Four major antigenic clusters corresponding to Phe(34)-Leu(59) (B1-2 and B1-3), Asp(112) -Glu(145) (B2-3 and B2-4), Gly(179)-Ala(225) (B3-2 to B3-4), and Val(261)-Asn(305) (B4-4 to B5-2) were identified. Collectively, the EB absorption and dot-blot assays established that the immunoreactive <span class="hlt">Por</span>B Ags were exposed on the surface of chlamydial EBs. Peptide-specific antisera raised to the surface-accessible Ags neutralized chlamydial infectivity and demonstrated cross-reactivity to synthetic peptides representing analogous C. pneumoniae <span class="hlt">Por</span>B sequences. Furthermore, neutralization of chlamydial infectivity by C. trachomatis <span class="hlt">Por</span>B antisera was inhibited by synthetic peptides representing the surface-exposed <span class="hlt">Por</span>B antigenic determinants. These findings demonstrate that <span class="hlt">Por</span>B Ags may be useful for development of chlamydial vaccines.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29667856','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29667856"><span>Low oxygen environment facilitates embryo availability for older ovarian responders (<span class="hlt">PORs</span>).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Li, Mingzhao; Li, Zhibin; Shi, Juanzi</p> <p>2018-04-18</p> <p>We aimed to investigate the different effects of low oxygen (5% O 2 ) and atmospheric oxygen (20% O 2 ) on in vitro fertilization for older poor ovarian responders (<span class="hlt">PORs</span>). We selected 1080 older <span class="hlt">PORs</span> who met two criteria: (i) advanced maternal age (≥40) and (ii) an abnormal ovarian reserve test. All the patients used the ultra-short term protocols with GnRH agonist and recombinant FSH for controlled ovarian hyperstimulation (COH). About 506 cycles were performed in the incubators with 5% O 2 and 574 cycles were performed in the incubators with 20% O 2 . No significant differences were observed in normal fertilization rates (59.68 versus 60.25%; p = .691) and cancelation rates (18.97 versus 19.34%; p = .879) between two groups. The number of available embryos (1.77 ± 0.57 versus 1.52 ± 0.50; p = .041) and mean number of cells on Day 3 (7.49 ± 1.82 versus 7.16 ± 1.70; p = .032) were significantly higher in 5% O 2 group compared to that in 20% O 2 group. It showed no significant differences in the implantation rates (27.43 versus 24.11%; p = .803) and clinical pregnancy rates (36.34 versus 30.05%; p = .307) between two groups. The employ of low oxygen culture did not improve clinical pregnancy rate for older <span class="hlt">PORs</span>. However, it benefited early embryonic development for older <span class="hlt">PORs</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://images.nasa.gov/#/details-PIA15017.html','SCIGOVIMAGE-NASA'); return false;" href="https://images.nasa.gov/#/details-PIA15017.html"><span>NASA Satellite Tracks Underwater Volcanic Eruption in Canary Islands</span></a></p> <p><a target="_blank" href="https://images.nasa.gov/">NASA Image and Video Library</a></p> <p></p> <p>2011-11-02</p> <p>In July 2011, volcanic tremors began on the Island of El <span class="hlt">Hierro</span> in the Canary Islands; by September, many tourists evacuated the resort island, fearing a volcanic eruption. This image is from NASA Terra spacecraft.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1998PhDT........95E','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1998PhDT........95E"><span>Inversor Resonante de Tres Elementos L-LC con Caracteristica Cortocircuitable para Aplicaciones de Calentamiento <span class="hlt">por</span> Induccion</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Espi Huerta, Jose Miguel</p> <p></p> <p>Los generadores de calentamiento <span class="hlt">por</span> induccion son puentes inversores con carga resonante, cuya mision es basicamente crear una corriente sinusoidal de gran amplitud sobre la "bobina de caldeo", que forma parte del tanque resonante. En el interior de esta bobina se introduce la pieza que se desea calentar. EI campo magnetico creado induce corrientes superficiales (corrientes de Foucault) sobre la pieza, que producen su calentamiento. Los tanques resonantes (tambien llamados osciladores) utilizados en la actualidad son el resonante serie y el resonante paralelo. Aunque ya desde hace algun tiempo se vienen construyendo generadores de alta potencia basados en estos dos osciladores, el exito nunca ha. sido completo en ninguno de los dos casos. Tal y como se explica en la introduccion de esta memoria, los puentes inversores utilizados deben operar sobre una carga inductiva (corriente retrasada) para evitar el fenomeno de la recuperacion inversa de sus diodos y la consiguiente ruptura de los transistores. De la restriccion topologica anterior se deduce que el generador paralelo debe conmutar a frecuencias inferiores a la resonancia, y el serie a frecuencias superiores. A esta restriccion topologica hay que unir otra que es exclusiva del calentamiento <span class="hlt">por</span> induccion: La corriente <span class="hlt">por</span> la bobina de caldeo debe ser sinusoidal. De no ser asi, resultaria imposible disponer toda la potencia de calentamiento sobre la pieza en el espesor requerido <span class="hlt">por</span> la aplicacion. Como consecuencia, los inversores no pueden operar <span class="hlt">por</span> debajo de la frecuencia de resonancia del oscilador, pues en ese caso se amplifican los armonicos de orden superior de la tension/corriente de entrada situados sobre la resonancia, con la consiguiente distorsion de la corriente de salida. La conjuncion de las dos restricciones anteriores obligan al inversor paralelo a funcionar a la frecuencia de resonancia del oscilador. Esto imposibilita un control <span class="hlt">por</span> variacion de frecuencia, regulandose la potencia desde la</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27285815','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27285815"><span>Multiple active site residues are important for photochemical efficiency in the light-activated enzyme protochlorophyllide oxidoreductase (<span class="hlt">POR</span>).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Menon, Binuraj R K; Hardman, Samantha J O; Scrutton, Nigel S; Heyes, Derren J</p> <p>2016-08-01</p> <p>Protochlorophyllide oxidoreductase (<span class="hlt">POR</span>) catalyzes the light-driven reduction of protochlorophyllide (Pchlide), an essential, regulatory step in chlorophyll biosynthesis. The unique requirement of the enzyme for light has provided the opportunity to investigate how light energy can be harnessed to power biological catalysis and enzyme dynamics. Excited state interactions between the Pchlide molecule and the protein are known to drive the subsequent reaction chemistry. However, the structural features of <span class="hlt">POR</span> and active site residues that are important for photochemistry and catalysis are currently unknown, because there is no crystal structure for <span class="hlt">POR</span>. Here, we have used static and time-resolved spectroscopic measurements of a number of active site variants to study the role of a number of residues, which are located in the proposed NADPH/Pchlide binding site based on previous homology models, in the reaction mechanism of <span class="hlt">POR</span>. Our findings, which are interpreted in the context of a new improved structural model, have identified several residues that are predicted to interact with the coenzyme or substrate. Several of the <span class="hlt">POR</span> variants have a profound effect on the photochemistry, suggesting that multiple residues are important in stabilizing the excited state required for catalysis. Our work offers insight into how the <span class="hlt">POR</span> active site geometry is finely tuned by multiple active site residues to support enzyme-mediated photochemistry and reduction of Pchlide, both of which are crucial to the existence of life on Earth. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25937559','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25937559"><span>Molecular phylogenetics of Micromeria (Lamiaceae) in the Canary Islands, diversification and inter-island colonization patterns inferred from nuclear genes.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Puppo, Pamela; Curto, Manuel; Gusmão-Guedes, Joana; Cochofel, Jaqueline; Pérez de Paz, Pedro Luis; Bräuchler, Christian; Meimberg, Harald</p> <p>2015-08-01</p> <p>Here we reconstruct the evolutionary history of Micromeria in the Canary Islands using eight nuclear markers. Our results show two centers of diversification for Micromeria, one in the eastern islands Gran Canaria and Lanzarote, the other in the western islands, Tenerife, La Palma and El <span class="hlt">Hierro</span>. Suggested directions of inter-island colonization are the following: Gran Canaria to Lanzarote and La Gomera; Tenerife to La Palma (from the paleoisland of Teno), to El <span class="hlt">Hierro</span> (from the younger, central part), and to La Gomera and Madeira (from the paleoislands). Colonization of La Gomera probably occurred several times from Gran Canaria and Tenerife. The taxonomic implications of these results are discussed. Incongruence among the different markers was evaluated and, using next generation sequencing, we investigated if this incongruence is due to gene duplication. Copyright © 2015 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1409271','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1409271"><span>VERA-CS User Support Activities for <span class="hlt">PoR</span> 14</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Kochunas, Brendan</p> <p>2017-11-01</p> <p>The purpose of this milestone is to document the user support activities that took place between 10/1/2016 and 3/31/2017 (<span class="hlt">PoR</span> 14). In the normal PHI workflow, that also extends to several activities within RTM, a Kanban process is followed. This involves creating tickets for specific work items and track the progress to complete these specific work items.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005LPI....36.1014J','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005LPI....36.1014J"><span>Fast-Turnoff Transient Electromagnetic (TEM) Field Study at the Mars Analog Site of Rio Tinto, Spain</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Jernsletten, J. A.</p> <p>2005-03-01</p> <p>This report describes a Fast-Turnoff Transient Electromagnetic (TEM) study at the Peña de <span class="hlt">Hierro</span> ("Berg of Iron") field area of the Mars Analog Research and Technology Experiment (MARTE), near the towns Rio Tinto and Nerva, Andalucia region, Spain.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29890104','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29890104"><span></span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Spitale, Luis Santos; Pizzi, Rogelio Daniel; Tomas, Axel; Paez Rearte, Mirtha Gladys; Pizzi, Hugo Luis</p> <p>2017-09-08</p> <p>RESUMENSe informan sesenta y cinco casos de enterobiasis del apéndice cecal <span class="hlt">por</span> Enterobius vermicularis u Oxiurus vermicularis. La enterobiasis es una parasitosis cosmopolita 5, 8,13 y frecuente. Es útil establecer si puede ser causa de apendicitis y los mecanismos involucrados. Según la literatura clásica, E. vermicularis, no es agente causal de apendicitis per se, pero permite la reproducción de los gérmenes que infiltran la pared y producen apendicitis.5, 9,10 El propósito del trabajo es informar la prevalencia de E. vermicularis en apendicitis quirúrgicas y la anatomopatología para deducir una relación causal. Informamos una muestra de 2000 piezas quirúrgicas de apéndices extraídos (1992-2003) en el Hospital de Urgencias de la ciudad de Córdoba, Argentina. Sobre un total de 2000 piezas, observamos 65 casos de enterobiasis apendicular; en 60 casos (3,25 %) no hubo histopatología propia de inflamación <span class="hlt">aguda</span> (apéndice cecal anodino). En los 5 casos restantes, (0,25 %) observamos coexistencia de parásitos en la luz apendicular, napas de infiltrado inflamatorio agudo transmural (apendicitis <span class="hlt">aguda</span>) y fecalitos, lo que apoyaría la etiopatogenia de tipo obstructivo que lleva al cuadro quirúrgico. La localización apendicular de Enterobius vermicularis favorecería la formación de fecalitos en la luz y la proliferación de gérmenes en la pared que llevaría a la apendicitis. Reportes señalan que la infección parasitaria constituye un porcentaje de las etiologías en apendicitis y los fecalitos son el desencadenante más común, pudiendo estar implicados en su formación algunos parásitos (Enterobius vermicularis), aunque este porcentaje es mínimo. 9, 10, 15,17.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24067336','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24067336"><span>Depth of origin of magma in eruptions.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Becerril, Laura; Galindo, Ines; Gudmundsson, Agust; Morales, Jose Maria</p> <p>2013-09-26</p> <p>Many volcanic hazard factors--such as the likelihood and duration of an eruption, the eruption style, and the probability of its triggering large landslides or caldera collapses--relate to the depth of the magma source. Yet, the magma source depths are commonly poorly known, even in frequently erupting volcanoes such as Hekla in Iceland and Etna in Italy. Here we show how the length-thickness ratios of feeder dykes can be used to estimate the depth to the source magma chamber. Using this method, accurately measured volcanic fissures/feeder-dykes in El <span class="hlt">Hierro</span> (Canary Islands) indicate a source depth of 11-15 km, which coincides with the main cloud of earthquake foci surrounding the magma chamber associated with the 2011-2012 eruption of El <span class="hlt">Hierro</span>. The method can be used on widely available GPS and InSAR data to calculate the depths to the source magma chambers of active volcanoes worldwide.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170175','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170175"><span>A role for <span class="hlt">POR</span>1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>D'Souza-Schorey, C; Boshans, R L; McDonough, M; Stahl, P D; Van Aelst, L</p> <p>1997-01-01</p> <p>The ARF6 GTPase, the least conserved member of the ADP ribosylation factor (ARF) family, associates with the plasma membrane and intracellular endosome vesicles. Mutants of ARF6 defective in GTP binding and hydrolysis have a marked effect on endocytic trafficking and the gross morphology of the peripheral membrane system. Here we report that expression of the GTPase-defective mutant of ARF6, ARF6(Q67L), remodels the actin cytoskeleton by inducing actin polymerization at the cell periphery. This cytoskeletal rearrangement was inhibited by co-expression of ARF6(Q67L) with deletion mutants of <span class="hlt">POR</span>1, a Rac1-interacting protein involved in membrane ruffling, but not with the dominant-negative mutant of Rac1, Rac1(S17N). A synergistic effect between <span class="hlt">POR</span>1 and ARF6 for the induction of actin polymerization was detected. Furthermore, we observed that ARF6 interacts directly with <span class="hlt">POR</span>1 and that this interaction was GTP dependent. These findings indicate that ARF6 and Rac1 function on distinct signaling pathways to mediate cytoskeletal reorganization, and suggest a role for <span class="hlt">POR</span>1 as an important regulatory element in orchestrating cytoskeletal rearrangements at the cell periphery induced by ARF6 and Rac1. PMID:9312003</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011SPIE.8166E..1MC','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011SPIE.8166E..1MC"><span>Effect of SPM-based cleaning <span class="hlt">POR</span> on EUV mask performance</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Choi, Jaehyuck; Lee, Han-shin; Yoon, Jinsang; Shimomura, Takeya; Friz, Alex; Montgomery, Cecilia; Ma, Andy; Goodwin, Frank; Kang, Daehyuk; Chung, Paul; Shin, Inkyun; Cho, H.</p> <p>2011-11-01</p> <p>EUV masks include many different layers of various materials rarely used in optical masks, and each layer of material has a particular role in enhancing the performance of EUV lithography. Therefore, it is crucial to understand how the mask quality and patterning performance can change during mask fabrication, EUV exposure, maintenance cleaning, shipping, or storage. The fact that a pellicle is not used to protect the mask surface in EUV lithography suggests that EUV masks may have to undergo more cleaning cycles during their lifetime. More frequent cleaning, combined with the adoption of new materials for EUV masks, necessitates that mask manufacturers closely examine the performance change of EUV masks during cleaning process. We have investigated EUV mask quality and patterning performance during 30 cycles of Samsung's EUV mask SPM-based cleaning and 20 cycles of SEMATECH ADT exposure. We have observed that the quality and patterning performance of EUV masks does not significantly change during these processes except mask pattern CD change. To resolve this issue, we have developed an acid-free cleaning <span class="hlt">POR</span> and substantially improved EUV mask film loss compared to the SPM-based cleaning <span class="hlt">POR</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2003cnam.conf...90S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2003cnam.conf...90S"><span>Detección y estudio mediante Fluorescencia Inducida <span class="hlt">por</span> Láser de radicales libres formados <span class="hlt">por</span> Disociación Multifotónica Infrarroja</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Santos, M.; Díaz, L.; Torresano, J. A.; Rubio, L.; Samoudi, B.</p> <p></p> <p>Una de las principales aplicaciones actuales de los procesos de disociación multifotónica inducidos <span class="hlt">por</span> radiación láser infrarroja (DMI) es la producción de radiales libres, con el fin de estudiar sus propiedades cinéticas y espectroscópicas. La disociación de moléculas poliatómicas en el IR con láseres de CO2 tiene lugar desde la superficie de energía molecular mas baja y conduce generalmente a la formación de fragmentos en el estado electrónico fundamental, con diversos grados de excitación vibracional. En el Grupo de Procesos Multifotónicos del Instituto de Estructura de la Materia del C.S.I.C. hemos puesto a punto la técnica de Fluorescencia Inducida <span class="hlt">por</span> Láser (LIF) para la detección y análisis en tiempo real de los fragmentos producidos en la DMI inducida mediante uno o dos campos láseres de diferentes longitudes de onda. Objetivos de nuestro trabajo han sido el estudio de los canales de disociación mayoritarios y de las especies transitoria producidas, así como de la distribución de energía interna con que éstas son generadas. En particular hemos detectado mediante LIF las especies: C2, CF, CH, SiH2, CF2, CH2, SiHCl, y CF3 a partir de la disociación de, entre otras, las siguientes moléculas: C2H3Br, C3F6, C4H8Si, C2H5ClSi y CH5ClSi. En este trabajo presentamos algunos de los resultados obtenidos mediante el estudio <span class="hlt">por</span> LIF de estos radicales: estudio temporal de la señal LIF obtenida con determinación de tiempos de vida, espectros de excitación y fluorescencia, temperaturas vibracionales de formación, variación de la intensidad LIF con el tiempo de retraso entre los láseres de disociación y prueba, etc.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA550476','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA550476"><span>Acoustic Detection, Behavior, and Habitat Use of Deep-Diving Odontocetes</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2011-09-22</p> <p>de Estudios de Biologia Marina. Alicante. Spain, Sept. 2010. Escanez A., Guerra A., Gonzalez A., Landeira J., Vicente A., Arranz P., Aguilar N...34Cefalopodos mesopelagicos capturados en las islas de El <span class="hlt">Hierro</span> u Tenerife durante la campana Zifiocal-I", Sociedad Iberico de Estudios de Biologia</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA542167','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA542167"><span>Acoustic Detection, Behavior, and Habitat Use of Deep-Diving Odontocetes</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2010-09-30</p> <p>Biologia Marina, Alicante, Sept. 2010. Escanez A., Guerra A., Gonzalez A., Landeira J., Vicente A., Arranz P., Aguilar N., "Cefalopodos...mesopelagicos capturados en las islas de El <span class="hlt">Hierro</span> u Tenerife durante la campana Zifiocal-I", Sociedad Iberico de Estudios de Biologia Marina, Alicante, Sept</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li class="active"><span>8</span></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_8 --> <div id="page_9" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li class="active"><span>9</span></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="161"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3783892','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3783892"><span>Depth of origin of magma in eruptions</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Becerril, Laura; Galindo, Ines; Gudmundsson, Agust; Morales, Jose Maria</p> <p>2013-01-01</p> <p>Many volcanic hazard factors - such as the likelihood and duration of an eruption, the eruption style, and the probability of its triggering large landslides or caldera collapses - relate to the depth of the magma source. Yet, the magma source depths are commonly poorly known, even in frequently erupting volcanoes such as Hekla in Iceland and Etna in Italy. Here we show how the length-thickness ratios of feeder dykes can be used to estimate the depth to the source magma chamber. Using this method, accurately measured volcanic fissures/feeder-dykes in El <span class="hlt">Hierro</span> (Canary Islands) indicate a source depth of 11–15 km, which coincides with the main cloud of earthquake foci surrounding the magma chamber associated with the 2011–2012 eruption of El <span class="hlt">Hierro</span>. The method can be used on widely available GPS and InSAR data to calculate the depths to the source magma chambers of active volcanoes worldwide. PMID:24067336</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1362136','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1362136"><span>Determinacion del error sistematico del momentum de muones producidos <span class="hlt">por</span> interacciones neutrino-nucleon en el detector MINER$$\</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Diaz Bautista, Gonzalo A.</p> <p></p> <p>El Modelo Estandar describe todas las partculas observadas en el naturaleza hasta el momento as como las caractersticas que gobiernan a las interacciones fundamentales entre ellas. En especial es posible identicar a las interacciones electromagnetica y debil, las cuales bajo determinadas condiciones de temperatura y energa pueden ser descritas a traves de una sola teora que engloba a ambas. A esta teora se le denomina electrodebil y tiene como nalidad caracterizar las propiedades de la interaccion maniesta a partir de la mezcla de las interacciones electromagnetica y debil, la que tambien lleva como nombre interaccion electrodebil. Particularmente, los neutrinos sonmore » de especial interes ya que, <span class="hlt">por</span> un lado, interactuan <span class="hlt">por</span> medio de la interaccion debil muy raramente en comparacion con otras partculas y, <span class="hlt">por</span> el otro, no son acertadamente descritos <span class="hlt">por</span> el Modelo Estandar. <span class="hlt">Por</span> medio de observaciones experimentales que demostraban que los neutrinos cambian de sabor al propagarse, fenomeno llamado oscilaciones de neutrinos, se pudo llegar a la conclusion de que la implicancia de este fenomeno da como consecuencia que los neutrinos efectivamente s tienen masa, algo que entra en contradiccion con la descripcion inicial del Modelo Estandar, el cual los describe como partculas sin masa. Es de esta manera que las oscilaciones de neutrinos han sido y siguen siendo en la actualidad objeto de interes en la Fsica de Altas Energas tanto teorica como experimental. A n de poder realizar mediciones precisas de oscilaciones de neutrinos, los experimentos encargados de estas mediciones deben tratar de reducir sus incertidumbres en lo posible. Una de estas proviene de la caracterizacion de las secciones de choque de los neutrinos cuando interactuan con la materia, particularmente los nucleones al interior de los nucleos atomicos. El experimento MINERA esta orientado, entre otras cosas, a hacer una correcta caracterizacion de secciones de choque neutrino-nucleon <span class="hlt">por</span> medio del</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3457995','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3457995"><span>Mapping the Laminin Receptor Binding Domains of Neisseria meningitidis <span class="hlt">Por</span>A and Haemophilus influenzae OmpP2</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Mahdavi, Jafar; Oldfield, Neil J.; Wheldon, Lee M.; Wooldridge, Karl G.; Ala'Aldeen, Dlawer A. A.</p> <p>2012-01-01</p> <p>Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae are major bacterial agents of meningitis. They each bind the 37/67-kDa laminin receptor (LamR) via the surface protein adhesins: meningococcal PilQ and <span class="hlt">Por</span>A, H. influenzae OmpP2 and pneumococcal CbpA. We have previously reported that a surface-exposed loop of the R2 domain of CbpA mediates LamR-binding. Here we have identified the LamR-binding regions of <span class="hlt">Por</span>A and OmpP2. Using truncated recombinant proteins we show that binding is dependent on amino acids 171–240 and 91–99 of <span class="hlt">Por</span>A and OmpP2, respectively, which are predicted to localize to the fourth and second surface-exposed loops, respectively, of these proteins. Synthetic peptides corresponding to the loops bound LamR and could block LamR-binding to bacterial ligands in a dose dependant manner. Meningococci expressing <span class="hlt">Por</span>A lacking the apex of loop 4 and H. influenzae expressing OmpP2 lacking the apex of loop 2 showed significantly reduced LamR binding. Since both loops are hyper-variable, our data may suggest a molecular basis for the range of LamR-binding capabilities previously reported among different meningococcal and H. influenzae strains. PMID:23049988</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23049988','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23049988"><span>Mapping the laminin receptor binding domains of Neisseria meningitidis <span class="hlt">Por</span>A and Haemophilus influenzae OmpP2.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Abouseada, Noha M; Assafi, Mahde Saleh A; Mahdavi, Jafar; Oldfield, Neil J; Wheldon, Lee M; Wooldridge, Karl G; Ala'Aldeen, Dlawer A A</p> <p>2012-01-01</p> <p>Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae are major bacterial agents of meningitis. They each bind the 37/67-kDa laminin receptor (LamR) via the surface protein adhesins: meningococcal PilQ and <span class="hlt">Por</span>A, H. influenzae OmpP2 and pneumococcal CbpA. We have previously reported that a surface-exposed loop of the R2 domain of CbpA mediates LamR-binding. Here we have identified the LamR-binding regions of <span class="hlt">Por</span>A and OmpP2. Using truncated recombinant proteins we show that binding is dependent on amino acids 171-240 and 91-99 of <span class="hlt">Por</span>A and OmpP2, respectively, which are predicted to localize to the fourth and second surface-exposed loops, respectively, of these proteins. Synthetic peptides corresponding to the loops bound LamR and could block LamR-binding to bacterial ligands in a dose dependant manner. Meningococci expressing <span class="hlt">Por</span>A lacking the apex of loop 4 and H. influenzae expressing OmpP2 lacking the apex of loop 2 showed significantly reduced LamR binding. Since both loops are hyper-variable, our data may suggest a molecular basis for the range of LamR-binding capabilities previously reported among different meningococcal and H. influenzae strains.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4431996','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4431996"><span>Prevalencia y tamizaje del Trastorno <span class="hlt">por</span> Déficit de Atención con Hiperactividad en Costa Rica</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Weiss, Nicholas T.; Schuler, Jovita; Monge, Silvia; McGough, James J.; Chavira, Denise; Bagnarello, Monica; Herrera, Luis Diego; Mathews, Carol A.</p> <p>2015-01-01</p> <p>Resumen La investigación tuvo como propósito estimar la prevalencia del Trastorno <span class="hlt">por</span> Déficit de Atención con Hiperactividad (TDAH) en Costa Rica y determinar si la versión en español del cuestionario Swanson Nolan and Pelham Scale IV (SNAP-IV) es un instrumento de tamizaje útil en una población de niños y niñas escolares costarricenses. El instrumento fue entregado a padres y maestros de 425 niños entre 5 y 13 años de edad (promedio = 8.8). Todos fueron evaluados con el instrumento Swanson, Kotkin, Agler, M-Flynn and Pelham Scale (SKAMP). Su diagnóstico fue confirmado con una entrevista clínica. La sensibilidad y la especificidad del SNAP-IV fueron evaluadas como predictores de criterios de diagnóstico según el DSM-IV. La prevalencia puntual en la muestra del TDAH fue del 5%. El tamizaje más preciso lo hizo el SNAP-IV completado <span class="hlt">por</span> el maestro en un corte de 20%, con una sensibilidad de 96% y una especificidad de un 82%. La sensibilidad de los instrumentos completados <span class="hlt">por</span> los padres fue más baja que aquella de los maestros. El SNAP-IV completado <span class="hlt">por</span> las maestras con un corte aislando el 20% de los mayores puntajes categorizó correctamente a un 87% de los sujetos. PMID:22432094</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28084436','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28084436"><span>Stress barriers controlling lateral migration of magma revealed by seismic tomography.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Martí, J; Villaseñor, A; Geyer, A; López, C; Tryggvason, A</p> <p>2017-01-13</p> <p>Understanding how monogenetic volcanic systems work requires full comprehension of the local and regional stresses that govern magma migration inside them and why/how they seem to change from one eruption to another. During the 2011-2012 El <span class="hlt">Hierro</span> eruption (Canary Islands) the characteristics of unrest, including a continuous change in the location of seismicity, made the location of the future vent unpredictable, so short term hazard assessment was highly imprecise. A 3D P-wave velocity model is obtained using arrival times of the earthquakes occurred during that pre-eruptive unrest and several latter post-eruptive seismic crises not related to further eruptions. This model reveals the rheological and structural complexity of the interior of El <span class="hlt">Hierro</span> volcanic island. It shows a number of stress barriers corresponding to regional tectonic structures and blocked pathways from previous eruptions, which controlled ascent and lateral migration of magma and, together with the existence of N-S regional compression, reduced its options to find a suitable path to reach the surface and erupt.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017NatSR...740757M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017NatSR...740757M"><span>Stress barriers controlling lateral migration of magma revealed by seismic tomography</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Martí, J.; Villaseñor, A.; Geyer, A.; López, C.; Tryggvason, A.</p> <p>2017-01-01</p> <p>Understanding how monogenetic volcanic systems work requires full comprehension of the local and regional stresses that govern magma migration inside them and why/how they seem to change from one eruption to another. During the 2011-2012 El <span class="hlt">Hierro</span> eruption (Canary Islands) the characteristics of unrest, including a continuous change in the location of seismicity, made the location of the future vent unpredictable, so short term hazard assessment was highly imprecise. A 3D P-wave velocity model is obtained using arrival times of the earthquakes occurred during that pre-eruptive unrest and several latter post-eruptive seismic crises not related to further eruptions. This model reveals the rheological and structural complexity of the interior of El <span class="hlt">Hierro</span> volcanic island. It shows a number of stress barriers corresponding to regional tectonic structures and blocked pathways from previous eruptions, which controlled ascent and lateral migration of magma and, together with the existence of N-S regional compression, reduced its options to find a suitable path to reach the surface and erupt.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5233990','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5233990"><span>Stress barriers controlling lateral migration of magma revealed by seismic tomography</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Martí, J.; Villaseñor, A.; Geyer, A.; López, C.; Tryggvason, A.</p> <p>2017-01-01</p> <p>Understanding how monogenetic volcanic systems work requires full comprehension of the local and regional stresses that govern magma migration inside them and why/how they seem to change from one eruption to another. During the 2011–2012 El <span class="hlt">Hierro</span> eruption (Canary Islands) the characteristics of unrest, including a continuous change in the location of seismicity, made the location of the future vent unpredictable, so short term hazard assessment was highly imprecise. A 3D P-wave velocity model is obtained using arrival times of the earthquakes occurred during that pre-eruptive unrest and several latter post-eruptive seismic crises not related to further eruptions. This model reveals the rheological and structural complexity of the interior of El <span class="hlt">Hierro</span> volcanic island. It shows a number of stress barriers corresponding to regional tectonic structures and blocked pathways from previous eruptions, which controlled ascent and lateral migration of magma and, together with the existence of N-S regional compression, reduced its options to find a suitable path to reach the surface and erupt. PMID:28084436</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28383967','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28383967"><span>Racism in digital era: Development and initial validation of the Perceived Online Racism Scale (<span class="hlt">PORS</span> v1.0).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Keum, Brian TaeHyuk; Miller, Matthew J</p> <p>2017-04-01</p> <p>The purpose of this study was to develop the Perceived Online Racism Scale (<span class="hlt">PORS</span>) to assess perceived online racist interpersonal interactions and exposure to online racist content among people of color. Items were developed through a multistage process involving a comprehensive literature review, focus-groups, qualitative data collection, and survey of online racism experiences. Based on a sample of 1,023 racial minority participants, exploratory and confirmatory factor analyses provided support for a 30-item bifactor model accounted by the general factor and the following 3 specific factors: (a) personal experience of racial cyber-aggression, (b) vicarious exposure to racial cyber-aggression, and (c) online-mediated exposure to racist reality. The <span class="hlt">PORS</span> demonstrated measurement invariance across racial/ethnic groups in our sample. Internal reliability estimates for the total and subscale scores of the <span class="hlt">PORS</span> were above .88 and the 4-week test-retest reliability was adequate. Limitations and future directions for research are discussed. (PsycINFO Database Record (c) 2017 APA, all rights reserved).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29336841','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29336841"><span>Economic impact of the new oral treatments for multiple sclerosis.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Álvarez Ayuso, L; Rodríguez Marrodán, B; Blasco Quílez, M R; García-Merino, J A; Sánchez Guerrero, A</p> <p>2018-01-11</p> <p>Multiple sclerosis (MS) is a chronic disease affecting the central nervous system and is characterised by inflammation, demyelination, gliosis, and axonal damage. The introduction of dimethyl fumarate and teriflunomide has led to an increase in the number of alternative first-line therapies for MS. The objective of this study was to evaluate the economic impact of the incorporation of new oral therapies at the reference unit (CSUR) at Hospital Universitario Puerta de <span class="hlt">Hierro</span> Majadahonda. We performed a retrospective observational study including patients diagnosed with MS, who underwent treatment with disease-modifying drugs in 2015 and were followed up for a minimum mean time of one year. Data were collected from patients' electronic clinical histories and the pharmacy service's programme for dispensing drugs to outpatients. Evaluating the cost of changing 125 patients' treatment from other drugs to dimethyl fumarate and teriflunomide, and comparing this with the cost that would have resulted from maintaining their previous treatment, demonstrated a total saving of €169,107.31 over the study period. In addition to contributing new therapeutic alternatives, dimethyl fumarate and teriflunomide produced an economic saving in MS treatment at our hospital. Copyright © 2017 Sociedad Española de Neurología. Publicado <span class="hlt">por</span> Elsevier España, S.L.U. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21250499','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21250499"><span>[Professor Frantisek <span class="hlt">Por</span> MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mydlík, M; Derzsiová, K</p> <p>2010-11-01</p> <p>Professor Frantisek <span class="hlt">Por</span> MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. <span class="hlt">Por</span> attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. <span class="hlt">Por</span> continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. <span class="hlt">Por</span> practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4623611','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4623611"><span>Aspergilosis cervical con diseminación al sistema nervioso central. Presentación de un caso y revisión de bibliografía</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Vergara, Guillermo Enrique; Roura, Natalia; del Castillo, Marcelo; Mora, Andrea; Alcorta, Santiago Condomi; Mormandi, Rubén; Cervio, Andrés; Salvat, Jorge</p> <p>2015-01-01</p> <p>Introducción: la Aspergilosis Invasiva (AI) del Sistema Nervioso Central (SNC) es infrecuente y ocurre generalmente en pacientes inmunocomprometidos. Puede presentarse con cuadros de meningitis, aneurismas micóticos, infartos o abscesos. Es una infección con pronóstico reservado y puede afectar el SNC de forma primaria o secundaria a partir de un foco que se disemina <span class="hlt">por</span> vía hematógena. Presentamos el caso de un paciente con AI con invasión primaria a nivel óseo y diseminación posterior al cerebro. Caso clínico: Paciente masculino de 25 años con diagnóstico de leucemia linfática <span class="hlt">aguda</span> en tratamiento quimioterápico que presentó neumonitis <span class="hlt">por</span> metotrexate <span class="hlt">por</span> lo que inicia tratamiento con corticoides. Posteriormente agregó cervicalgia y con el diagnóstico de osteomielitis cervical se realiza punción bajo tomografía computada (TC) sin aislarse gérmenes. Se colocó Halo Vest e inició tratamiento antibiótico empírico. Posteriormente presentó afasia de expresión secundaria a lesión frontal izquierda. Se realizó evacuación de absceso cerebral aislando A. fumigatus. El tratamiento antibiótico específico posterior permitió una buena respuesta clínica y radiológica. Conclusión: La presencia de lesiones en el SNC de pacientes inmunocomprometidos debe incluir a las micosis como diagnóstico diferencial. La evacuación quirúrgica permite llegar rápidamente al diagnóstico mejorando la respuesta posterior al tratamiento antibiótico. Para evaluar la respuesta terapéutica y posibles recaídas se debe realizar un seguimiento periódico clínico radiológico. Palabras clave: Aspergilosis cerebral; Aspergilosis cervical; Aspergilosis invasiva; Voriconazol. PMID:26600985</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27982372','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27982372"><span>Use of medicines and other products for therapeutic purposes among children in Brazil.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Pizzol, Tatiane da Silva Dal; Tavares, Noemia Urruth Leão; Bertoldi, Andréa Dâmaso; Farias, Mareni Rocha; Arrais, Paulo Sergio Dourado; Ramos, Luiz Roberto; Oliveira, Maria Auxiliadora; Luiza, Vera Lucia; Mengue, Sotero Serrate</p> <p>2016-12-01</p> <p>átrica brasileira e testar se fatores demográficos, socioeconômicos e médicos estão associados ao uso. Estudo transversal de base populacional (Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - PNAUM), incluindo 7.528 crianças com 12 anos ou menos de idade, residentes na zona urbana do território brasileiro. O uso de medicamentos para tratar doenças crônicas ou <span class="hlt">agudas</span> foi referido pelo principal cuidador da criança presente na entrevista domiciliar. Associações entre as variáveis independentes e o uso de medicamentos foram investigadas <span class="hlt">por</span> meio de regressão de Poisson. A prevalência de uso global de medicamentos foi de 30,7% (IC95% 28,3-33,1). A prevalência de uso de medicamentos para doenças crônicas foi de 5,6% (IC95% 4,7-6,7) e para condições <span class="hlt">agudas</span>, 27,1% (IC95% 24,8-29,4). Os fatores significativamente associados com o uso global foram ter no máximo cinco anos de idade, residir na região Nordeste, ter plano de saúde e utilizar serviços de saúde nos últimos 12 meses (consultas de emergência e internações). Associaram-se ao uso de medicamentos para doenças crônicas: idade ≥ 2 anos, regiões Sudeste e Sul e utilização de serviços de saúde. Para o uso de medicamentos em condições <span class="hlt">agudas</span>, foram identificados os seguintes fatores associados: ≤ 5 anos, Norte, Nordeste ou Centro-Oeste, plano de saúde e uma ou mais consultas de emergência. Os medicamentos com maior prevalência de uso pelas crianças menores de dois anos foram paracetamol, ácido ascórbico e dipirona; nas crianças com 2 ou mais anos, foram dipirona, paracetamol e amoxicilina. O uso de medicamentos na população infantil é substancial, principalmente no tratamento de condições médicas <span class="hlt">agudas</span>. As crianças usuárias de medicamentos para doenças crônicas apresentam perfil demográfico diferente das usuárias de medicamentos para condições <span class="hlt">agudas</span>, em relação ao sexo, à idade e à região geográfica.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4819071','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4819071"><span>Encefalitis <span class="hlt">por</span> anticuerpos contra el receptor de NMDA: experiencia con seis pacientes pediátricos. Potencial eficacia del metotrexato</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Bravo-Oro, Antonio; Abud-Mendoza, Carlos; Quezada-Corona, Arturo; Dalmau, Josep; Campos-Guevara, Verónica</p> <p>2016-01-01</p> <p>Introducción La encefalitis <span class="hlt">por</span> anticuerpos contra el receptor de N-metil-D-aspartato (NMDA) es una entidad cada vez más diagnosticada en edad pediátrica. A diferencia de los adultos, en muchos casos no se asocia a tumores y las manifestaciones iniciales en niños más frecuentes son crisis convulsivas y trastornos del movimiento, mientras que en los adultos predominan las alteraciones psiquiátricas. Casos clínicos Presentamos seis casos pediátricos confirmados con anticuerpos contra la subunidad NR1 del receptor de NMDA en suero y líquido cefalorraquídeo. Cinco de los casos comenzaron con crisis convulsivas como manifestación clínica inicial antes de desarrollar el cuadro clásico de esta entidad. En todos los casos se utilizaron esteroides como primera línea de tratamiento, con los que sólo se observó control de las manifestaciones en uno, <span class="hlt">por</span> lo que el resto de los pacientes requirió inmunomoduladores de segunda línea. Todos los pacientes recibieron metotrexato como tratamiento inmunomodulador para evitar recaídas y la evolución fue a la mejoría en todos ellos. Conclusiones En nuestra serie de pacientes con encefalitis <span class="hlt">por</span> anticuerpos contra el receptor de NMDA, ninguno se asoció a tumores. Todos los casos recibieron metotrexato <span class="hlt">por</span> lo menos durante un año, no observamos eventos adversos clínicos ni <span class="hlt">por</span> laboratorio, ni hubo secuelas neurológicas ni recaídas durante el tratamiento. Aunque es una serie pequeña y es deseable incrementar el número y tiempo de evolución, consideramos el metotrexato una excelente alternativa como tratamiento inmunomodulador para esta patología. PMID:24150952</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5121618','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5121618"><span>Structural and functional probing of <span class="hlt">Por</span>Z, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Lasica, Anna M.; Goulas, Theodoros; Mizgalska, Danuta; Zhou, Xiaoyan; de Diego, Iñaki; Ksiazek, Mirosław; Madej, Mariusz; Guo, Yonghua; Guevara, Tibisay; Nowak, Magdalena; Potempa, Barbara; Goel, Apoorv; Sztukowska, Maryta; Prabhakar, Apurva T.; Bzowska, Monika; Widziolek, Magdalena; Thøgersen, Ida B.; Enghild, Jan J.; Simonian, Mary; Kulczyk, Arkadiusz W.; Nguyen, Ky-Anh; Potempa, Jan; Gomis-Rüth, F. Xavier</p> <p>2016-01-01</p> <p>Porphyromonas gingivalis is a member of the human oral microbiome abundant in dysbiosis and implicated in the pathogenesis of periodontal (gum) disease. It employs a newly described type-IX secretion system (T9SS) for secretion of virulence factors. Cargo proteins destined for secretion through T9SS carry a recognition signal in the conserved C-terminal domain (CTD), which is removed by sortase <span class="hlt">Por</span>U during translocation. Here, we identified a novel component of T9SS, <span class="hlt">Por</span>Z, which is essential for surface exposure of <span class="hlt">Por</span>U and posttranslational modification of T9SS cargo proteins. These include maturation of enzyme precursors, CTD removal and attachment of anionic lipopolysaccharide for anchorage in the outer membrane. The crystal structure of <span class="hlt">Por</span>Z revealed two β-propeller domains and a C-terminal β-sandwich domain, which conforms to the canonical CTD architecture. We further documented that <span class="hlt">Por</span>Z is itself transported to the cell surface via T9SS as a full-length protein with its CTD intact, independently of the presence or activity of <span class="hlt">Por</span>U. Taken together, our results shed light on the architecture and possible function of a novel component of the T9SS. Knowledge of how T9SS operates will contribute to our understanding of protein secretion as part of host-microbiome interactions by dysbiotic members of the human oral cavity. PMID:27883039</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27797865','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27797865"><span>The enhanced immune responses induced by Salmonella enteritidis ghosts loaded with Neisseria gonorrhoeae <span class="hlt">por</span>B against Salmonella in mice.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Jiao, Hongmei; Yang, Hui; Zhao, Dan; He, Li; Chen, Jin; Li, Guocai</p> <p>2016-11-01</p> <p>Human health has been seriously endangered by highly prevalent salmonellosis and multidrug-resistant Salmonella strains. Current vaccines suffer from variable immune-protective effects, so more effective ones are needed to control Salmonella infection : Bacterial ghosts have been produced by the expression of lysis gene E from bacteriophage PhiX174 and can be filled with considerable exogenous substances such as DNA or drugs as a novel platform. In this study, Salmonella enteritidis (SE) ghosts were developed and loaded with Neisseria gonorrhoeae porin B (<span class="hlt">por</span>B) to construct a novel inactive vaccine. Our new studies show that SE ghosts loaded with <span class="hlt">por</span>B displayed increased production of pro-inflammatory cytokines (IL-1β, IL-6, IL-10 and IL-12p70) in bone marrow-derived dendritic cells (BMDCs), and elicited significantly higher specific systemic and mucosal immune responses to Salmonella than SE ghosts alone. In addition, the novel <span class="hlt">por</span>B-loaded ghosts conferred higher protective effects on virulent Salmonella challenge. For the first time, we demonstrate that N. gonorrhoeae <span class="hlt">por</span>B, as a novel adjuvant, can increase the immunogenicity of SE ghosts. Our studies suggested that Salmonella enteritidis ghosts loaded with Neisseria gonorrhoeae porin B might be a useful mucosal Salmonella vaccine candidate for practical use in the future. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28713419','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28713419"><span>Population Structure, Genetic Diversity, and Evolutionary History of Kleinia neriifolia (Asteraceae) on the Canary Islands.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sun, Ye; Vargas-Mendoza, Carlos F</p> <p>2017-01-01</p> <p>Kleinia neriifolia Haw. is an endemic species on the Canarian archipelago, this species is widespread in the coastal thicket of all the Canarian islands. In the present study, genetic diversity and population structure of K. neriifolia were investigated using chloroplast gene sequences and nuclear SSR (simple sequence repeat). The differentiation among island populations, the historical demography, and the underlying evolutionary scenarios of this species are further tested based on the genetic data. Chloroplast diversity reveals a strong genetic divergence between eastern islands (Gran Canaria, Fuerteventura, and Lanzarote) and western islands (EI <span class="hlt">Hierro</span>, La Palma, La Gomera, Tenerife), this west-east genetic divergence may reflect a very beginning of speciation. The evolutionary scenario with highest posterior probabilities suggests Gran Canaria as oldest population with a westward colonization path to Tenerife, La Gomera, La Palma, and EI <span class="hlt">Hierro</span>, and eastward dispersal path to Lanzarote through Fuerteventura. In the western islands, there is a slight decrease in the effective population size toward areas of recent colonization. However, in the eastern islands, the effective population size increase in Lanzarote relative to Gran Canaria and Fuerteventura. These results further our understanding of the evolution of widespread endemic plants within Canarian archipelago.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5492869','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5492869"><span>Population Structure, Genetic Diversity, and Evolutionary History of Kleinia neriifolia (Asteraceae) on the Canary Islands</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Sun, Ye; Vargas-Mendoza, Carlos F.</p> <p>2017-01-01</p> <p>Kleinia neriifolia Haw. is an endemic species on the Canarian archipelago, this species is widespread in the coastal thicket of all the Canarian islands. In the present study, genetic diversity and population structure of K. neriifolia were investigated using chloroplast gene sequences and nuclear SSR (simple sequence repeat). The differentiation among island populations, the historical demography, and the underlying evolutionary scenarios of this species are further tested based on the genetic data. Chloroplast diversity reveals a strong genetic divergence between eastern islands (Gran Canaria, Fuerteventura, and Lanzarote) and western islands (EI <span class="hlt">Hierro</span>, La Palma, La Gomera, Tenerife), this west–east genetic divergence may reflect a very beginning of speciation. The evolutionary scenario with highest posterior probabilities suggests Gran Canaria as oldest population with a westward colonization path to Tenerife, La Gomera, La Palma, and EI <span class="hlt">Hierro</span>, and eastward dispersal path to Lanzarote through Fuerteventura. In the western islands, there is a slight decrease in the effective population size toward areas of recent colonization. However, in the eastern islands, the effective population size increase in Lanzarote relative to Gran Canaria and Fuerteventura. These results further our understanding of the evolution of widespread endemic plants within Canarian archipelago. PMID:28713419</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011JGeo...51..358A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011JGeo...51..358A"><span>Verifying the body tide at the Canary Islands using tidal gravimetry observations</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Arnoso, J.; Benavent, M.; Bos, M. S.; Montesinos, F. G.; Vieira, R.</p> <p>2011-05-01</p> <p>Gravity tide records from El <span class="hlt">Hierro</span>, Tenerife and Lanzarote Islands (Canarian Archipelago) have been analyzed and compared to the theoretical body tide model (DDW) of Dehant el al. (1999). The use of more stringent criterion of tidal analysis using VAV program allowed us to reduce the error bars by a factor of two of the gravimetric factors at Tenerife and Lanzarote compared with previous published values. Also, the calibration values have been revisited at those sites. Precise ocean tide loading (OTL) corrections based on up-to-date global ocean models and improved regional ocean model have been obtained for the main tidal harmonics O 1, K 1, M 2, S 2. We also point out the importance of using the most accurate coastline definition for OTL calculations in the Canaries. The remaining observational errors depend on the accuracy of the calibration of the gravimeters and/or on the length of the observed data series. Finally, the comparison of the tidal observations with the theoretical body tide models has been done with an accuracy level of 0.1% at El <span class="hlt">Hierro</span>, 0.4% at Tenerife and 0.5% at Lanzarote.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014AGUFMEP21D3566G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014AGUFMEP21D3566G"><span>U-Pb Detrital Zircon Geochronologic Constraints on Depositional Age and Sediment Source Terrains of the Late Paleozoic Tepuel-Genoa Basin</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Griffis, N. P.; Montanez, I. P.; Isbell, J.; Gulbranson, E. L.; Wimpenny, J.; Yin, Q. Z.; Cúneo, N. R.; Pagani, M. A.; Taboada, A. C.</p> <p>2014-12-01</p> <p>The late Paleozoic Ice Age (LPIA) is the longest-lived icehouse of the Phanerozoic and the only time a metazoan dominated and vegetated world transitioned from an icehouse climate into a greenhouse. Despite several decades of research, the timing, extent of glaciation and the location of ice centers remain unresolved, which prohibits reconstruction of ice volume. The Permo-Carboniferous sediments in the Tepuel-Genoa Basin, Patagonia contains a near complete record of sedimentation from the lower Carboniferous through lower Permian. Outsized clasts, thin pebble-rich diamictites and slumps represent the last of the late Paleozoic glacially influenced deep-water marine sediments in the Mojón de <span class="hlt">Hierro</span> Fm. and the Paleozoic of Patagonia. U-Pb analysis of detrital zircons separated from slope sediments reveal groupings (20 myr bins, n≥5 zircons) with peak depositional ages of 420, 540 to 660 and 1040 Ma. Zircon age populations recovered from the Mojón de <span class="hlt">Hierro</span> Fm. compare well with bedrock ages of the Deseado Massif of SE Patagonia, suggesting this may be a potential source of sediments. The maximum depositional age of the sediments is 306.05 ± 3.7 Ma (2σ) as determined by the median age of the two youngest concordant zircons that overlap in error. The youngest zircon from the analysis yields a 238U/206Pb age of 301.3 ± 4.5 Ma (2σ; MSWD = 2.3). Younger zircons from the analysis compare well with the age of granite bedrock exposed along the basin margin to the E-NE suggesting they may reflect a more proximal source. These data, which indicate a maximum age of late Carboniferous for the Mojón de <span class="hlt">Hierro</span> Fm, provide the first geochemical constraints for the timing of final deposition of glaciomarine sediments in the Tepuel-Genoa Basin, and contributes to the biostratigraphic correlation of the late Paleozoic succession in Patagonia with other key LPIA basins that has thus far been hindered by faunal provincialism.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li class="active"><span>9</span></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_9 --> <div id="page_10" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li class="active"><span>10</span></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="181"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3101880','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3101880"><span>Diagnóstico diferencial en la encefalitis <span class="hlt">por</span> anticuerpos contra el receptor NMDA</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>González-Valcárcel, J.; Rosenfeld, M.R.; Dalmau, J.</p> <p>2011-01-01</p> <p>Resumen Introducción La encefalitis <span class="hlt">por</span> anticuerpos contra el receptor de NMDA (NMDAR) suele desarrollarse como un síndrome característico de evolución multifásica y diagnóstico diferencial amplio. Pacientes Presentamos a 2 pacientes diagnosticadas de encefalitis <span class="hlt">por</span> anticuerpos NMDAR con un cuadro clínico típico, pero que inicialmente señaló otras etiologías. Discusión La afectación frecuente de pacientes jóvenes con manifestaciones psiquiátricas prominentes indica frecuentemente otras consideraciones diagnósticas; las más frecuentes son las encefalitis virales, los procesos psiquiátricos y el síndrome neuroléptico maligno. Varios síndromes previamente definidos de manera parcial o descriptiva en adultos y pacientes pediátricos probablemente eran casos de encefalitis anti-NMDAR. Conclusiones La encefalitis anti-NMDAR debe considerarse en pacientes jóvenes con manifestaciones psiquiátricas subagudas, movimientos anormales y alteraciones autonómicas. La caracterización clínica e inmunológica de esta enfermedad ha llevado a la identificación de nuevos anticuerpos que afectan a procesos de memoria, aprendizaje, conducta y psicosis. PMID:20964986</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2003BASBr..23R.183S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2003BASBr..23R.183S"><span>Reconstrução tridimensional de arcos magnéticos <span class="hlt">por</span> tomografia</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Simões, P. J. A.; Costa, J. E. R.</p> <p>2003-08-01</p> <p>Uma explosão solar é uma variação súbita do brilho que ocorre nas regiões ativas da atmosfera solar. Estas regiões são constituídas <span class="hlt">por</span> um plasma magnetizado com intensa indução magnética e em cenários bem complexos como visto recentemente através de experimentos embarcados em satélites operando instrumentos em raios X moles e ultra-violeta distante. A energia magnética, que pode ser armazenada <span class="hlt">por</span> um período de horas até dias em configurações magnéticas estressadas, é subitamente lançada na atmosfera solar e transferida para partículas como elétrons, prótons e núcleos pesados, que são acelerados e/ou aquecidos, produzindo radiação eletromagnética. A proposta final deste projeto é determinar as características espaciais de alta resolução da emissão e polarização girossincrotrônica de explosões solares em ambientes complexos de campos magnéticos. Os recentes resultados da emissão difusa em EUV apresentado pelos satélites TRACE e SOHO dos arcos magnéticos conectando as diferentes polaridades magnéticas sobre as regiões ativas possibilitam novas abordagens sobre o papel do campo magnético na emissão em rádio. Nesta etapa apresentamos os resultados da reconstrução da geometria tridimensional das linhas de força destes arcos utilizando técnicas tomográficas, a partir de imagens de alta resolução espacial obtidas pelo instrumento EIT (Extreme ultraviolet Imaging Telescope), além da modelagem das induções magnéticas <span class="hlt">por</span> um campo dipolar e as densidades de partículas aceleradas. Utilizamos para a reconstrução geométrica, imagens tomadas em vários ângulos dos arcos devido à rotacão solar. Com estes resultados, daremos continuidade ao projeto, com os cálculos da transferência radiativa nos modos ordinário e extraordinário de propagação da radiação girossincrotrônica de explosões solares.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=GRANADA&pg=4&id=EJ511987','ERIC'); return false;" href="https://eric.ed.gov/?q=GRANADA&pg=4&id=EJ511987"><span>The Acquisition of Lexical Meaning in a Study Abroad Context: The Spanish Prepositions "<span class="hlt">por</span>" and "para."</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Lafford, Barbara A.; Ryan, John M.</p> <p>1995-01-01</p> <p>Examination of the development of form/function relations of the prepositions "<span class="hlt">por</span>" and "para" at different levels of proficiency in the interlanguage of study-abroad students in Granada, Spain, revealed "noncanonical" as well as "canonical" uses of these prepositions. The most common noncanonical uses were…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28489169','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28489169"><span>MORTALITY OF URGENCY VERSUS ELECTIVE VIDEOLAPAROSCOPIC CHOLECYSTECTOMY FOR ACUTE CHOLECYSTITIS.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Felício, Saulo José Oliveira; Matos, Ediriomar Peixoto; Cerqueira, Antonio Maurício; Farias, Kurt Wolfgang Schindler Freire de; Silva, Ramon de Assis; Torres, Mateus de Oliveira</p> <p>2017-01-01</p> <p>Surgical approach is still controversial in patients with acute cholecystitis: to treat clinically the inflammatory process and operate electively later or to operate immediately on an emergency basis? To test the hypothesis that urgent laparoscopic cholecystectomy in acute cholecystitis has a higher mortality than elective laparoscopic cholecystectomy. From the data available in Datasus, mortality was compared between patients undergoing elective laparoscopic cholecystectomy for cholelithiasis and in urgency. Calculations were made of the relative reduction in risk of death, absolute reduction of risk of death and number needed to treat. From 2009 to 2014 in Brazil, there were 250.439 laparoscopic cholecystectomy and 74.6% were electives. Mortality in the emergency group was 4.8 times higher compared to the elective group (0.0023% vs. 0.00048%). Despite the relative reduction in risk of death (RRR) was 83%, in the calculation of absolute risk was found 0.0018 and number needed to treat of 55,555. Despite the relative risk reduction for mortality was high comparing elective vs. urgent basis, the absolute risk reduction was minimal, since this outcome is very low in both groups, suggesting that mortality should not have much influence on surgical decision. Continua controversa a conduta nos pacientes com colecistite <span class="hlt">aguda</span>: compensar o processo inflamatório e operar eletivamente ou operar imediatamente em caráter de urgência? Testar a hipótese de que a colecistectomia videolaparoscópica de urgência <span class="hlt">por</span> colecistite <span class="hlt">aguda</span> apresenta maior mortalidade que a colecistectomia videolaparoscópica eletiva. A partir dos dados disponíveis no Datasus, foi comparada a mortalidade entre os pacientes submetidos à colecistectomia videolaparoscópica eletiva <span class="hlt">por</span> colelitíase e a de urgência. Foram realizados cálculos da redução relativa de risco de morte, redução absoluta do risco de morte e número necessário para tratar . De 2009 a 2014 no Brasil, foram realizadas</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA598664','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA598664"><span>Population Parameters of Blainville’s and Cuvier’s Beaked Whales</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2013-09-30</p> <p><span class="hlt">Hierro</span>. May 2013-2014. ULL. Current. Phil Hammond • Harbour seal diet around Scotland: evidence for competition with grey seals (Scottish...in three meetings and conferences: Aguilar de Soto, N. et al. 2013. From the Canary Islands sucess to the Mediterranean : Areas of Special Concern...Setubal (Portugal) Aguilar de Soto, N. (2012) Proposal of inclusion in Annex I CMS: Mediterranean subpopulation of Cuvier´s beaked whale Ziphius</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4739292','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4739292"><span>Alterações Induzidas Pelo Exercício no Número, Função e Morfologia de Monócitos de Ratos</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>GUERESCHI, MARCIA G.; PRESTES, JONATO; DONATTO, FELIPE F.; DIAS, RODRIGO; FROLLINI, ANELENA B.; FERREIRA, CLÍLTON KO.; CAVAGLIERI, CLAUDIA R.; PALANCH, ADRIANNE C.</p> <p>2008-01-01</p> <p>O propósito desse estudo foi verificar as alterações histofisiológicas em monócitos e macrófagos induzidas <span class="hlt">por</span> curtos períodos de exercícios. Ratos Wistar (idade = 2 meses, peso corporal = 200g) foram divididos em sete grupos (n=6 cada): controle sedentário (C), grupos exercitados (natação) na intensidade leve <span class="hlt">por</span> 5 (5L), 10 (10L) e 15 minutos (15L), e grupos exercitados em intensidade moderada <span class="hlt">por</span> 5 (5M), 10 (10M) e 15 minutes (15M). Na intensidade moderada os animais carregaram uma carga de 5% do peso corporal dos mesmos em seus respectivos dorsos. Os monócitos sangüíneos foram avaliados quanto à quantidade e morfologia e os macrófagos peritoneais foram analisados quanto à quantidade e atividade fagocitária. Os dados foram analisados usando ANOVA e Tukey’s post hoc test (p ≤ 0,05). Os grupos de intensidade leve e 5M apresentaram aumento nos níveis dos monócitos quando comparados com o controle. Foi observado aumento na área celular dos monócitos para os grupos 5L, 10L, 5M e 10M; a área nuclear aumentou para os grupos 10L, 5M e 10M em comparação com o controle. Houve aumento nos macrófagos peritoneais para os grupos 15L, 10M, 15M e diminuição no grupo 5M. A capacidade fagocitária dos macrófagos aumentou nos grupos de intensidade leve e para o grupo 10M. O exercício realizado <span class="hlt">por</span> curtos períodos modulou o número e função dos macrófagos, assim como o número e morfologia dos monócitos, sendo tais alterações dependentes da intensidade. A soma das respostas <span class="hlt">agudas</span> observadas nesse estudo pode exercer um efeito protetor contra doenças, podendo ser utilizada para a melhora da saúde e qualidade de vida.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16027004','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16027004"><span>Improved purification of native meningococcal porin <span class="hlt">Por</span>B and studies on its structure/function.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Massari, Paola; King, Carol A; MacLeod, Heather; Wetzler, Lee M</p> <p>2005-12-01</p> <p>The outer membrane protein <span class="hlt">Por</span>B of Neisseria meningitidis is a pore-forming protein which has various effects on eukaryotic cells. It has been shown to (1) up-regulate the surface expression of the co-stimulatory molecule CD86 and of MHC class II (which are TLR2/MyD88 dependent and related to the porin's immune-potentiating ability), (2) be involved in prevention of apoptosis by modulating the mitochondrial membrane potential, and (3) form pores in eukaryotic cells. As an outer membrane protein, its native trimeric form isolation is complicated by its insoluble nature, requiring the presence of detergent throughout the whole procedure, and by its tight association with other outer membrane components, such as neisserial LOS or lipoproteins. In this study, an improved chromatographic purification method to obtain an homogeneous product free of endotoxin and lipoprotein is described, without loss of any of the above-mentioned properties of the porin. Furthermore, we have investigated the requirement of the native trimeric structure for the porin's activity. Inactivation of functional <span class="hlt">Por</span>B trimers into non-functional monomers was achieved by incubation on ice. Thus, routine long- and medium-term storage at low temperature may be a cause of porin inactivation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5915859','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5915859"><span>Avaliação do conhecimento de pacientes diabéticos sobre medidas preventivas do pé diabético em Maringá (PR)</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Carlesso, Guilherme Pereira; Gonçalves, Mariana Helena Barboza; Moreschi, Dorival</p> <p>2017-01-01</p> <p>Resumo Contexto O atual envelhecimento da população tem gerado maior predominância de doenças crônicas, como o diabetes, a qual está associada a um risco elevado de complicações crônicas e <span class="hlt">agudas</span>. Entre essas, o pé diabético (PD) destaca-se <span class="hlt">por</span> possuir alta incidência e grande poder mutilador. Objetivo Avaliar o conhecimento da população diabética das Unidades Básicas de Saúde (UBS) de Maringá (PR) sobre a prevenção do PD. Métodos Estudo descritivo, quantitativo, tipo inquérito <span class="hlt">por</span> entrevista. A população estudada foi composta <span class="hlt">por</span> 80 portadores de diabetes, cadastrados em UBS de Maringá (PR). A coleta de dados buscou levantar dados sociodemográficos e epidemiológicos, bem como as atitudes de controle do diabetes e do autocuidado para prevenção do PD. Resultados Do total de entrevistados, nove não realizavam qualquer tipo de exame para controle do diabetes e a renda mensal predominante foi de até um salário mínimo. O grau de escolaridade e a renda mensal não se mostraram relevantes em relação ao conhecimento de cuidados preventivos do PD e nem uma maior adesão a hábitos de vida saudáveis. O cuidado com o PD tende a melhorar à medida que exista uma compreensão mais clara dos fatores que conduzem à perda do membro e um crescente consenso sobre a gestão de vários aspectos clínicos do cuidado com o pé. Conclusão Existe uma falta de aprendizado das medidas preventivas, mesmo nos pacientes com algum nível de instrução, o que induz a uma prática deficiente de cuidados.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4278719','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4278719"><span>Adjuvant Effects Elicited by Novel Oligosaccharide Variants of Detoxified Meningococcal Lipopolysaccharides on Neisseria meningitidis Recombinant <span class="hlt">Por</span>A Protein: A Comparison in Mice</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Mehta, Ojas H.; Norheim, Gunnstein; Hoe, J . Claire; Rollier, Christine S.; Nagaputra, Jerry C.; Makepeace, Katherine; Saleem, Muhammad; Chan, Hannah; Ferguson, David J. P.; Jones, Claire; Sadarangani, Manish; Hood, Derek W.; Feavers, Ian; Derrick, Jeremy P.; Pollard, Andrew J.; Moxon, E . Richard</p> <p>2014-01-01</p> <p>Neisseria meningitidis lipopolysaccharide (LPS) has adjuvant properties that can be exploited to assist vaccine immunogenicity. The modified penta-acylated LPS retains the adjuvant properties of hexa-acylated LPS but has a reduced toxicity profile. In this study we investigated whether two modified glycoform structures (LgtE and IcsB) of detoxified penta-acylated LPS exhibited differential adjuvant properties when formulated as native outer membrane vesicles (nOMVs) as compared to the previously described LgtB variant. Detoxified penta-acylated LPS was obtained by disruption of the lpxL1 gene (LpxL1 LPS), and three different glycoforms were obtained by disruption of the lgtB, lgtE or icsB genes respectively. Mice (mus musculus) were immunized with a recombinant <span class="hlt">Por</span>A P1.7-2,4 (r<span class="hlt">Por</span>A) protein co-administered with different nOMVs (containing a different <span class="hlt">Por</span>A serosubtype P1.7,16), each of which expressed one of the three penta-acylated LPS glycoforms. All nOMVs induced IgG responses against the r<span class="hlt">Por</span>A, but the nOMVs containing the penta-acylated LgtB-LpxL1 LPS glycoform induced significantly greater bactericidal activity compared to the other nOMVs or when the adjuvant was Alhydrogel. Compared to LgtE or IcsB LPS glycoforms, these data support the use of nOMVs containing detoxified, modified LgtB-LpxL1 LPS as a potential adjuvant for future meningococcal protein vaccines. PMID:25545241</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=history+AND+Argentina&id=EJ1031141','ERIC'); return false;" href="https://eric.ed.gov/?q=history+AND+Argentina&id=EJ1031141"><span>Global Microlending in Education Reform: Enseñá <span class="hlt">Por</span> Argentina and the Neoliberalization of the Grassroots</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Friedrich, Daniel S.</p> <p>2010-01-01</p> <p>This article examines the workings and underlying assumptions behind Enseñá <span class="hlt">por</span> Argentina (Teach for Argentina), one specific program that takes part in the larger and expanding network of Teach for All, by thinking about the ways in which a global push for redefining teaching and teacher education encounters local characteristics and histories,…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016PhDT........78M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016PhDT........78M"><span>Concepciones y concepciones alternativas de estudiantes universitarios/as de biologia y futuros maestros/as de Ciencia de escuela secundaria sobre la teoria de evolucion biologica <span class="hlt">por</span> seleccion natural</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Morales Ramos, Egda M.</p> <p></p> <p>La teoria de evolucion biologica (TEB) <span class="hlt">por</span> seleccion natural es uno de los conceptos unificadores mas importantes del curriculo de Biologia. En Puerto Rico se han hecho pocas investigaciones que abunden sobre las concepciones y concepciones alternativas (CA) que tienen los estudiantes universitarios/as de Biologia y los maestros/as de Ciencia del nivel secundario sobre esta teoria. La politica publica educativa actual establece mediante documentos normativos como los Estandares de contenido y Expectativas de grado del Programa de Ciencias [Puerto Rico Core Standards] la ensenanza de esta teoria. Sin embargo, no se encontraron preguntas sobre la seleccion natural en los ejercicios de practica provistos <span class="hlt">por</span> el Departamento de Educacion para las pruebas estandarizadas lo cual puede influir para que no se ensene adecuadamente. Las preguntas de investigacion fueron 1. ¿Cuales son las concepciones y concepciones alternativas de estudiantes universitarios/as y de los futuros maestros y maestras de Ciencia sobre la TEB? 2. ¿Cuales conceptos que seleccionan los estudiantes universitarios/as y los futuros maestros y maestras de Ciencia sobre la TEB coinciden con lo aceptado como valido <span class="hlt">por</span> la comunidad cientifica? y 3. ¿Como comparan las respuestas de la prueba original. v. Entendiendo el cambio biologico que mide concepciones y CA sobre la TEB <span class="hlt">por</span> seleccion natural, con las de la traducida al idioma espanol? Se utilizo el metodo cuantitativo con un diseno de investigacion transversal <span class="hlt">por</span> encuesta. La tecnica principal para recopilar los datos fue una prueba con doce items, que formo parte de un instrumento para el cual se recopilaron diversas fuentes de evidencia acerca de su validez. Las muestras estuvieron formadas <span class="hlt">por</span> 69 estudiantes de Ciencias Naturales y <span class="hlt">por</span> 16 estudiantes futuros maestros y maestras del nivel secundario de la UPR-RP. Se utilizaron estadisticas descriptivas, analisis de Ji cuadrado y se calcularon los coeficientes alfa de Cronbach y de Spearman</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUFMOS41C1987S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUFMOS41C1987S"><span>Combination of ORP and pH sensors in tow-yo studies to map redox and acid-base anomalies in seawater due to hydrothermal activity in shallow areas</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Santana-Casiano, J. M.; González-Dávila, M.; Fraile-Nuez, E.; Santana-González, C.; Baker, E. T.; Resing, J. A.; Walker, S. L.</p> <p>2016-12-01</p> <p>The detection of activity from low-temperature hydrothermal vents, where the increase in temperature is not evident, requires the utilization of alternative sensors that respond to emissions of certain chemical species. The character of both reduced and acid fluids in the volcanic emissions in the El <span class="hlt">Hierro</span> submarine volcano allowed us to detect anomalies related with changes in the chemical potential and the proton concentration using ORP and pH sensors, respectively. Tow-yos with these sensors provided the approximate locations of the emissions plotting δ(ORP)/δt and ΔpH versus the latitude or longitude. The ORP sensor responds very quickly to the presence of reduced chemicals in the water column. The magnitude of this change is examined by the time derivative of ORP, δ(ORP)/δt. For pH changes, ΔpH, the mean pH for each depth at a reference station in an area not affected by the vent emission is subtracted from each point measured near the volcanic edifice. The submarine volcano of El <span class="hlt">Hierro</span>, in its degasification stage, provided an excellent opportunity to apply CTD-pH-ORP tow-yo methodology and to study the effect of CO2 emission on the seawater carbonate system, the global carbon flux, and local ocean acidification. Detailed surveys of the volcanic edifice were carried out during VULCANO 0314 and VULCANA0615 cruises using several CTD-pH-ORP tow-yo studies, localizing the redox and acidic changes, which were used to obtain surface maps of anomalies. CTD-pH-ORP yo-yo studies were also conducted that included discrete sampling for carbonate system parameters and total dissolved Fe(II), TDFe(II). The inputs of CO2 along multiple sections combined with measurements of oceanic currents produced an estimated volcanic CO2 flux = 6.0 105 ± 1.1 105 kg d-1and increases the acidity above the volcano by 20%. From the yo-yo studies important anomalies in both pHT and TDFe(II) were observed. The increased TDFe(II) concentrations and the low associated pHT values may</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=STS030-73-087&hterms=hierro&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D60%26Ntt%3Dhierro','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=STS030-73-087&hterms=hierro&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D60%26Ntt%3Dhierro"><span>Canary Island Archipelago</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p></p> <p>1989-01-01</p> <p>This nearly vertical view of the Canary Archipelago (28.5N, 16.5W) shows five of the seven islands: Grand Canary, Tenerife, Gomera, <span class="hlt">Hierro</span> and La Palma. The largest island in view is Tenerife. Island cloud wakes evident in this photo are the result of southerly winds giving rise to cloud banks on the lee side especially on Tenerife which has the highest volcanic peaks. Island water wakes and internal waves are also evident but not as apparent.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3170814','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3170814"><span>Pincharse sin infectarse: estrategias para prevenir la infección <span class="hlt">por</span> el VIH y el VHC entre usuarios de drogas inyectables</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>MATEU-GELABERT, P.; FRIEDMAN, S.; SANDOVAL, M.</p> <p>2011-01-01</p> <p>Resumen Objetivo Desde principios de los noventa, en la ciudad de Nueva York se han implementado con éxito programas para reducir la incidencia del virus de la inmunodeficiencia humana (VIH) y, en menor medida, del virus de la hepatitis C (VHC). A pesar de ello, aproximadamente el 70% de los usuario de drogas inyectables (UDI) están infectados <span class="hlt">por</span> el VHC. Queremos investigar cómo el 30% restante se las ha arreglado para no infectarse. El Staying safe (nombre original del estudio) explora los comportamientos y mecanismos que ayudan a evitar la infección <span class="hlt">por</span> el VHC y el VIH a largo plazo. Material y métodos Hemos utilizado el concepto de «desviación positiva» aplicado en otros campos de salud pública. Estudiamos las estrategias, prácticas y tácticas de prevención de aquellos UDI que, viviendo en contextos de alta prevalencia, se mantienen sin infectar <span class="hlt">por</span> VIH y el VHC, a pesar de haberse inyectado heroína durante años. Los resultados preliminares presentados en este artículo incluyen el análisis de las entrevistas realizadas a 25 UDI (17 doble negativos, 3 doble positivos y 5 con infección <span class="hlt">por</span> el VHC y sin infección <span class="hlt">por</span> el VIH). Se usaron entrevistas semiestructuradas que exploraban con detalle la historia de vida de los sujetos, incluyendo su consumo de drogas, redes sociales, contacto con instituciones, relaciones sexuales y estrategias de protección y vigilancia. Resultados La intencionalidad es importante para no infectarse, especialmente durante períodos de involución (períodos donde hay un deterioro económico y/o social que llevan al que se inyecta a situaciones de mayor riesgo). Presentamos tres dimensiones independientes de intencionalidad que conllevan comportamientos que pueden ayudar a prevenir la infección: a) evitar «el mono» (síntomas de abstención) asegurando el acceso a la droga; b) «llevarlo bien» para no convertirse en un junkie y así evitar la «muerte social» y la falta de acceso a los recursos, y c) seguir sin</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/345016','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/345016"><span>Acceptance test report for portable exhauster <span class="hlt">POR</span>-007/Skid E</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Kriskovich, J.R.</p> <p>1998-07-24</p> <p>This document describes Acceptance Testing performed on Portable Exhauster <span class="hlt">POR</span>-007/Skid E. It includes measurements of bearing vibration levels, pressure decay testing, programmable logic controller interlocks, high vacuum, flow and pressure control functional testing. The purpose of Acceptance testing documented by this report was to demonstrate compliance of the exhausters with the performance criteria established within HNF-0490, Rev. 1 following a repair and upgrade effort at Hanford. In addition, data obtained during this testing is required for the resolution of outstanding Non-conformance Reports (NCR), and finally, to demonstrate the functionality of the associated software for the pressure control and high vacuummore » exhauster operating modes provided for by W-320. Additional testing not required by the ATP was also performed to assist in the disposition and close out of receiving inspection report and for application design information (system curve). Results of this testing are also captured within this document.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28099552','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28099552"><span>Association between the concentration of fine particles in the atmosphere and acute respiratory diseases in children.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nascimento, Antônio Paula; Santos, Jane Meri; Mill, José Geraldo; Souza, Juliana Bottoni de; Reis, Neyval Costa; Reisen, Valdério Anselmo</p> <p>2017-01-12</p> <p>To analyze the association between fine particulate matter concentration in the atmosphere and hospital care by acute respiratory diseases in children. Ecological study, carried out in the region of Grande Vitória, Espírito Santo, in the winter (June 21 to September 21, 2013) and summer (December 21, 2013 to March 19, 2014). We assessed data of daily count for outpatient care and hospitalization by respiratory diseases (ICD-10) in children from zero to 12 years in three hospitals in the Region of Grande Vitória. For collecting fine particulate matter, we used portable samplers of particles installed in six locations in the studied region. The Generalized Additive Model with Poisson distribution, fitted for the effects of predictor covariates, was used to evaluate the relationship between respiratory outcomes and concentration of fine particulate matter. The increase of 4.2 µg/m3 (interquartile range) in the concentration of fine particulate matter increased in 3.8% and 5.6% the risk of medical care or hospitalization, respectively, on the same day and with six-day lag from the exposure. We identified positive association between outpatient care and hospitalizations of children under 12 years due to acute respiratory diseases and the concentration of fine particulate matter in the atmosphere. Analisar a associação entre a concentração de material particulado fino na atmosfera e atendimento hospitalar <span class="hlt">por</span> doenças respiratórias <span class="hlt">agudas</span> em crianças. Estudo ecológico, realizado na Região da Grande Vitória, ES, no inverno (21 de junho a 21 de setembro de 2013) e no verão (21 de dezembro de 2013 a 19 de março de 2014). Foram avaliados dados de contagem diária de atendimentos ambulatoriais e hospitalizações <span class="hlt">por</span> doenças respiratórias (CID-10) em crianças de zero a 12 anos em três hospitais da Região da Grande Vitoria. Para a coleta de material particulado fino foram utilizados amostradores portáteis de partículas instalados em seis locais na regi</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5047372','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5047372"><span>Relaciones entre el sueño y la adicción</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Cañellas, Francesca; de Lecea, Luis</p> <p>2016-01-01</p> <p>Resumen La interacción entre los trastornos del sueño y el abuso de sustancias es ya conocida, pero seguramente más compleja de lo que se pensaba. Existe tanto una relación positiva entre tener un trastorno <span class="hlt">por</span> uso de substancias y sufrir un trastorno de sueño, como viceversa. Los efectos sobre el sueño dependen de la substancia utilizada, pero se ha demostrado que tanto durante su uso como en período de abstinencia los consumidores tienen diferentes problemas de sueño y fundamentalmente un sueño más fragmentado. Sabemos que hay que tener en cuenta los problemas de sueño para evitar recaídas en la adicción. Investigaciones recientes indican que el sistema hipocretinérgico definido <span class="hlt">por</span> el neuropéptido hipocretina/orexina (Hcrt/ox), localizado en el hipotálamo lateral e implicado entre otros en la regulación del ciclo sueño-vigilia, jugaría un papel importante en las conductas adictivas. Diferentes estudios han demostrado interacciones entre el sistema hipocretinérgico, los circuitos de respuesta <span class="hlt">aguda</span> al estrés y los sistemas de recompensa. También sabemos que la activación optogenética selectiva del sistema hipocretinérgico incrementa la probabilidad de la transición del sueño a la vigilia, y también es suficiente para iniciar un comportamiento compulsivo de recaída adictiva. La activación del sistema hipocretinérgico podría explicar la hipervigilia asociada al estrés y a la adicción. El mayor conocimiento de esta interacción permitiría entender mejor los mecanismos de la adicción y encontrar nuevas estrategias para el tratamiento de las adicciones. PMID:23241715</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26992134','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26992134"><span>Nursing Diagnosis Based on Signs and Symptoms of Patients With Heart Disease.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>da Costa, Cíntia; da Costa Linch, Graciele Fernanda; Nogueira de Souza, Emiliane</p> <p>2016-10-01</p> <p>The aim was to identify the main signs and symptoms of cardiac patients hospitalized in a unit of intensive cardiology care in order to infer the main nursing diagnoses (NDs). We performed a cross-sectional study; the sample consisted of 77 randomly selected records. Those records included only patients hospitalized for cardiovascular causes and with electronic chart available. Signs and symptoms identified at admission were psychic (40.3%), compressive dressing on arterial puncture site (33.8%), chest pain (29.9%), tachycardia (22.1%), and hemodynamic instability (20.8%). According to the data collected, we were able to infer that acute pain, excess of fluid volume, decreased cardiac output, spontaneous ventilation impaired, anxiety and impaired skin integrity are priority for the NDs in the studied population. OBJETIVO: identificar os principais sinais e sintomas de pacientes cardíacos internados em uma unidade de cuidados intensivos de cardiologia, visando inferir os diagnósticos de enfermagem prioritários. MÉTODO: Estudo transversal; a amostra foi composta <span class="hlt">por</span> 77 registros selecionados aleatoriamente. Incluíram-se apenas pacientes internados <span class="hlt">por</span> causa cardiovascular e com registro eletrônico disponível. Os sinais e sintomas identificados na admissão foram psíquicos (40,3%), curativo compressivo em sítio de punção arterial (33,8%), dor torácica (29,9%), taquicardia (22,1%) e instabilidade hemodinâmica (20,8%). CONCLUSÕES E IMPLICAÇÕES PARA A PRÁTICA: De acordo com os dados levantados foram inferidos Dor <span class="hlt">Aguda</span>, Volume de Líquidos Excessivo, Débito Cardíaco Diminuído, Ventilação Espontânea Prejudicada, Ansiedade e Integridade da Pele Prejudicada como diagnósticos de enfermagem prioritários para a população estudada. © 2016 NANDA International, Inc.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22210488-study-interaction-mechanisms-between-absorbed-sub-por-si-sno-sub-nanocomposite-layers','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22210488-study-interaction-mechanisms-between-absorbed-sub-por-si-sno-sub-nanocomposite-layers"><span>Study of the interaction mechanisms between absorbed NO{sub 2} and <span class="hlt">por</span>-Si/SnO{sub x} nanocomposite layers</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Bolotov, V. V.; Kan, V. E., E-mail: kan@obisp.oscsbras.ru; Makushenko, R. K.</p> <p>2013-10-15</p> <p>The interaction mechanisms between NO{sub 2} molecules and the surface of <span class="hlt">por</span>-Si/SnO{sub x} nanocomposites obtained by magnetron deposition and chemical vapor deposition (CVD) are studied by infrared absorption spectroscopy and electron paramagnetic resonance methods. The observed increase in the free carrier concentration in the <span class="hlt">por</span>-Si/SnO{sub x} nanocomposite layers is explained by a change in the charge state of P{sub b} centers due to the formation of neutral 'surface defect-adsorbed NO{sub 2} molecule' complexes with free carrier generation in the crystallite bulk. In the nanocomposite layers grown by the CVD method, the increase in the free hole concentration during NO{sub 2}more » adsorption is much less pronounced in comparison with the composite grown by magnetron deposition, which is caused by the competing interaction channel of NO{sub 2} molecules with electrically neutral P{sub b} centers.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/345017','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/345017"><span>Acceptance test report for portable exhauster <span class="hlt">POR</span>-008/Skid F</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Kriskovich, J.R.</p> <p>1998-07-24</p> <p>Portable Exhauster <span class="hlt">POR</span>-008 was procured via HNF-0490, Specification for a Portable Exhausted System for Waste Tank Ventilation. Prior to taking ownership, acceptance testing was performed at the vendors. However at the conclusion of testing a number of issues remained that required resolution before the exhausters could be used by Project W-320. The purpose of acceptance testing documented by this report was to demonstrate compliance of the exhausters with the performance criteria established within HNF-O49O, Rev. 1 following a repair and upgrade effort at Hanford. In addition, data obtained during this testing is required for the resolution of outstanding Non-conformance Reportsmore » (NCR), and finally, to demonstrate the functionality of the associated software for the pressure control and high vacuum exhauster operating modes provided for by W-320. Additional testing not required by the ATP was also performed to assist in the disposition and close out of receiving inspection report and for application design information (system curve). Results of this testing are also captured within this document.« less</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li class="active"><span>10</span></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_10 --> <div id="page_11" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li class="active"><span>11</span></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="201"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011SNEA....1...34V','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011SNEA....1...34V"><span>Análise dos Conceitos Astronômicos Apresentados <span class="hlt">por</span> Professores de Algumas Escolas Estaduais Brasileiras</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Voelzke, Marcos Rincon; Gonzaga, Edson Pereira</p> <p>2011-12-01</p> <p>A razão para o desenvolvimento deste trabalho baseia-se no fato de que muitos professores da Educação Básica (EB) não lidam com conceitos relacionados à astronomia, e quando o fazem eles simplesmente seguem livros didáticos que podem conter erros conceituais. Como é de conhecimento geral a astronomia é um dos conteúdos a serem ensinados na EB fazendo parte dos Parâmetros Curriculares Nacionais e das Propostas Curriculares do Estado de São Paulo, mas é um fato, que vários pesquisadores apontam, a existência de muitos problemas no ensino da astronomia. Com o propósito de minimizar algumas dessas deficiências foi realizado um trabalho de pesquisa com a utilização de questionários pré e pós pesquisa, para tanto foi desenvolvido um Curso de Extensão Universitária para professores da Diretoria de Ensino Regional (DE) que abrange Mauá, Ribeirão Pires e Rio Grande da Serra (no Estado de São Paulo) com os seguintes objetivos: levantar concepções alternativas; subsidiar os professores <span class="hlt">por</span> meio de palestras, debates e workshops, e verificar o sucesso da aprendizagem após o curso, adotando-se como referência, para a análise dos resultados, os dicionários de Língua Portuguesa (FERREIRA, 2004) e Enciclopédico de Astronomia e Astronáutica (MOURĀO, 1995). Portanto, dezesseis questões foram aplicadas antes e após o curso, assim pode-se verificar após a pesquisa que 100,0% dos professores sabiam os nomes das fases da Lua, 97,0% entenderam que o Sistema Solar é composto <span class="hlt">por</span> oito planetas, 78,1% foram capazes de explicar como ocorre um eclipse lunar, um eclipse solar e um solstício, 72,7% sabiam como explicar a ocorrência das estações do ano; 64,5% explicaram corretamente a ocorrência do equinócio, 89,7% foram capazes de definir adequadamente o termo cometa; 63,6% definiram asteróide, 54,5% meteoro, 58,1% galáxia, e 42,4% planeta. Os resultados obtidos indicam uma aprendizagem significativa <span class="hlt">por</span> parte dos participantes.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA227701','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA227701"><span>The Foreign Policy of Venezuela Toward El Salvador: 1979-1983</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>1990-06-01</p> <p>vista extra-regional, la "zona vital" es rica en materiales estrat~gicos, tales como el petr6leo, el <span class="hlt">hierro</span>, y el aluminlo. Adem~s del petr6leo de...nivel de post-grado, en el Area de hidrocarburos para el periodo 1981 / 1982. Ofrecimiento de cooperaci6n en el campo de geologia de uranlo y materiales ...hombre, yo lo conocia, aparte de que era un homnbre muy preparado, muy inteligente , era un fan~tico. *Un fanatico religioso. Yo s6 porque lo digo</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/1166907-using-pors-problems-examine-evolutionary-optimization-multiscale-systems','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/1166907-using-pors-problems-examine-evolutionary-optimization-multiscale-systems"><span>Using the <span class="hlt">PORS</span> Problems to Examine Evolutionary Optimization of Multiscale Systems</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Reinhart, Zachary; Molian, Vaelan; Bryden, Kenneth</p> <p>2013-01-01</p> <p>Nearly all systems of practical interest are composed of parts assembled across multiple scales. For example, an agrodynamic system is composed of flora and fauna on one scale; soil types, slope, and water runoff on another scale; and management practice and yield on another scale. Or consider an advanced coal-fired power plant: combustion and pollutant formation occurs on one scale, the plant components on another scale, and the overall performance of the power system is measured on another. In spite of this, there are few practical tools for the optimization of multiscale systems. This paper examines multiscale optimization of systemsmore » composed of discrete elements using the plus-one-recall-store (<span class="hlt">PORS</span>) problem as a test case or study problem for multiscale systems. From this study, it is found that by recognizing the constraints and patterns present in discrete multiscale systems, the solution time can be significantly reduced and much more complex problems can be optimized.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUFM.V11C2787A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUFM.V11C2787A"><span>Volcanic soil gas 4He/CO2 ratio: a useful geochemical tool for eruption forecasting</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Asensio-Ramos, M.; Perez, N. M.; Padron, E.; Melián, G.; Hernandez Perez, P. A.; Padilla, G.; Barrancos, J.; Rodríguez, F.; Sumino, H.; Calvo, D.</p> <p>2016-12-01</p> <p>Magmatic gases that percolate through volcano's porous flanks in a non-visible (diffuse) way disturb the chemical composition of soil gases at the surface environment of the volcano, generating enrichments of CO2, He and other gases. Two of the gases which have attracted attention in soil degassing studies are He and CO2 because both species have similar low solubility in silicate melts. However, once they are exsolved from the melts, their movement through the crust towards the surface is very different: CO2, which is a reactive gas, is affected by the occurrence of interfering processes, while interaction of He during its ascent is minimum. Their geochemical differences yield higher relative He/CO2 ratios in the fumarole gases than is actually present in the magma, but it decreases when the magma reservoir reaches enough pressure to generate incipient fracture systems approaching the eruption. In this work, we present quasi daily estimations of diffusive He through the whole surface of El <span class="hlt">Hierro</span>, the youngest island of the Canarian archipelago, considering He emission data reported in the literature (Padrón et al., 2013. Geology, 41, 539-542), using the same procedure as for diffuse CO2 emission time series (Melián et al., 2014. J. Geophys. Res., 119, 6976-6991). After the occurrence of more than 11,000 seismic events, a shallow submarine eruption about 2 km off the south coast in the southernmost part of El <span class="hlt">Hierro</span>, started in October 12, 2011 and lasted for 5 month. The herein presented methodology enables the calculation of the diffuse He/CO2 emission ratio of the entire island during the volcanic unrest. Two different emission peaks for both He and CO2, with approximately the same delay between them ( 23 days), were observed. The combination of both time series resulted in a drastic increase in the He/CO2 emission ratio of the island (up to 1.1×10-3) two weeks before the eruption onset. Additionally, a second significant He/CO2 emission peak (up to 5.5×10</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27812679','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27812679"><span>Acute Ethanol Intake Induces NAD(P)H Oxidase Activation and Rhoa Translocation in Resistance Arteries.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Simplicio, Janaina A; Hipólito, Ulisses Vilela; Vale, Gabriel Tavares do; Callera, Glaucia Elena; Pereira, Camila André; Touyz, Rhian M; Tostes, Rita de Cássia; Tirapelli, Carlos R</p> <p>2016-11-01</p> <p> em artérias de resistência e o papel das espécies reativas de oxigênio (ERO) derivadas da NAD(P)H oxidase nessa resposta. Nós também avaliamos se ocorreu translocação da p47phox e ativação da NAD(P)H oxidase após o consumo agudo de etanol. Ratos Wistar machos foram tratados com etanol via oral (1g/kg, p.o. gavagem) ou água (controle). Alguns ratos foram tratados com vitamina C (250 mg/kg, p.o. gavagem, 5 dias) antes de água ou etanol. O leito arterial mesentérico (LAM) foi coleado 30 min após a administração de etanol. A vitamina C preveniu o aumento da geração de ânion superóxido (O2 -) e lipoperoxidação no LAM induzidos pelo etanol. A atividade da catalase (CAT), da superóxido dismutase (SOD) e os níveis de glutationa reduzida(GSH), nitrato e peróxido de hidrogênio (H2O2) não foram afetados após a ingestão <span class="hlt">aguda</span> de etanol. A vitamina C e o 4-metilpirazol preveniram o aumento na geração de O2 - induzido pelo etanol em cultura de células do músculo liso vascular (CMLV). O etanol não afetou a fosforilação da proteína quinase B (Akt) e nem da óxido nítrico sintase endotelial (eNOS) (nos resíduos de Ser1177 ou Thr495) ou a reatividade vascular do LAM. A vitamina C preveniu o aumento da razão membrana:citosol da p47phox e a expressão da RhoA no LAM de rato induzido pelo etanol. A ingestão <span class="hlt">aguda</span> de etanol induz a ativação da via RhoA/Rho quinase <span class="hlt">por</span> um mecanismo que envolve a geração de ERO. Nas artérias de resistência, o etanol ativa NAD(P)H oxidase induzindo a translocação da p47phox <span class="hlt">por</span> um mecanismo redox-sensível.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED101100.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED101100.pdf"><span>Adult Student Retention and Achievement with Language-Based Modular Materials. <span class="hlt">POR</span> FIN: Program Organizing Related Family Instruction in the Neighborhood.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Bexar County School Board, San Antonio, TX.</p> <p></p> <p>The goal of the <span class="hlt">POR</span> FIN research design was to develop a language-based curriculum emphasizing the audiolingual approach and integrating academic and social-functioning subject matter. The modular curriculum is designed so that each lesson is independent and complete in itself, and provides a high degree of motivation, retention, and achievement…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28372482','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28372482"><span>Characterisation by multilocus sequence and <span class="hlt">por</span>A and flaA typing of Campylobacter jejuni isolated from samples of dog faeces collected in one city in New Zealand.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mohan, V; Stevenson, M A; Marshall, J C; French, N P</p> <p>2017-07-01</p> <p>To investigate the prevalence of Campylobacter spp. and C. jejuni in dog faecal material collected from dog walkways in the city of Palmerston North, New Zealand, and to characterise the C. jejuni isolates by multilocus sequence typing (MLST) and <span class="hlt">por</span>A and flaA antigen gene typing. A total of 355 fresh samples of dogs faeces were collected from bins provided for the disposal of dog faeces in 10 walkways in Palmerston North, New Zealand, between August 2008-July 2009. Presumptive Campylobacter colonies, cultured on modified charcoal cefoperazone deoxycholate plates, were screened for genus Campylobacter and C. jejuni by PCR. The C. jejuni isolates were subsequently characterised by MLST and <span class="hlt">por</span>A and flaA typing, and C. jejuni sequence types (ST) were assigned. Of the 355 samples collected, 72 (20 (95% CI=16-25)%) were positive for Campylobacter spp. and 22 (6 (95% CI=4-9)%) were positive for C. jejuni. Of the 22 C. jejuni isolates, 19 were fully typed by MLST. Ten isolates were assigned to the clonal complex ST-45 and three to ST-52. The allelic combinations of ST-45/flaA 21/<span class="hlt">por</span>A 44 (n=3), ST-45/flaA 22/<span class="hlt">por</span>A 53 (n=3) and ST-52/ flaA 57/<span class="hlt">por</span>A 905 (n=3) were most frequent. The successful isolation of C. jejuni from canine faecal samples collected from faecal bins provides evidence that Campylobacter spp. may survive outside the host for at least several hours despite requiring fastidious growth conditions in culture. The results show that dogs carry C. jejuni genotypes (ST-45, ST-50, ST-52 and ST-696) that have been reported in human clinical cases. Although these results do not provide any evidence either for the direction of infection or for dogs being a potential risk factor for human campylobacteriosis, dog owners are advised to practice good hygiene with respect to their pets to reduce potential exposure to infection.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012AGUFM.V44B..06P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012AGUFM.V44B..06P"><span>Diffuse Helium Emission as a Precursory Sign of Volcanic Unrest</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Padron, E.; Perez, N.; Hernandez Perez, P. A.; Sumino, H.; Melian Rodriguez, G.; Barrancos, J.; Nolasco, D.; Padilla, G.; Dionis, S.; Rodriguez, F.; Hernandez, I.; Calvo, D.; Peraza, M.; Nagao, K.</p> <p>2012-12-01</p> <p>Since July 16, 2011, an anomalous seismicity at El <span class="hlt">Hierro</span> island, the youngest and smallest of the Canary Islands, was recorded by IGN seismic network. After the occurrence of more than 10,000 seismic events, volcanic tremor was recorded since 05:15 of the October 10, by all of the seismic stations on the island, with highest amplitudes recorded in the southernmost station. During the afternoon of October 12 a large light-green coloured area was observed in the sea to the souht of La Restinga village (at the southernmost part of El <span class="hlt">Hierro</span> island), suggesting the existence of a submarine eruption. Since October 12, frequent episodes of, turbulent gas emission and foaming, and the appearance of steamy lava fragments has been observed on the sea surface. As part of the volcanic surveillance of the island, the Instituto Volcanologico de Canarias (INVOLCAN) geochemical monitoring program is carrying out diffuse helium surveys on the surface environment of El <span class="hlt">Hierro</span> (soil atmosphere). This nobel gas has been investigated because it has been considered an almost ideal geochemical indicator because it is chemically inert, physically stable, nonbiogenic, sparingly soluble in water under ambient conditions and almost non-adsorbable. At each survey, 600 sampling sites covering the whole island and following an homogeneous distribution are selected for helium measurements in the soil gases, The helium concentration gradients with respect to its value on air (5.24 ppm) allow us to estimate a pure diffusive emission rate of helium throughout the island. The first survey was carried out on the summer of 2003, when the island was on a quiescence period. At this survey, the amount of helium released by the volcanic system of El <span class="hlt">Hierro</span> was estimated in 6 kg/d. Since the beginning of the seismic unrest, 13 helium emission surveys have been carried out. The helium emission rate has shown an excellent agreement with the evolution of the volcanic crisis of the island, reaching 30 kg</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA195304','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA195304"><span>Medical Civic Action Programs (MEDCAPS) and Medical Readiness Training Exercises (MEDRETES) as Instruments of Foreign Policy</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>1988-05-24</p> <p>term for their program, namely GUARDE, which stands for Guiar de Assistancia Resistancia De Enfermedades (Guided Assistance to Resistance to Sickness...Measles, Tetanus, Toxoid,- BCG). 2. Tuberculosis 3. C.E.D. (Control de Enfermedades Diarreicas) Control of Diarrhea (Oral Rehidration) 4. I.R.A...Infecciones Respiratorias <span class="hlt">Agudas</span>) Acute Respiratory Infections ,. 5. Rabia . Rabies -control " 6.. .T. S.-.( Enfermedades de Transmisi6n Sexual) S ", -T</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://images.nasa.gov/#/details-GSFC_20171208_Archive_e001798.html','SCIGOVIMAGE-NASA'); return false;" href="https://images.nasa.gov/#/details-GSFC_20171208_Archive_e001798.html"><span>Canary Islands</span></a></p> <p><a target="_blank" href="https://images.nasa.gov/">NASA Image and Video Library</a></p> <p></p> <p>2012-01-03</p> <p>NASA image acquired December 21, 2011 The rugged landscape of the Canary Islands stood out in sharp contrast to the smooth blue waters of the Atlantic Ocean and the flat tan land of northwestern Africa on December 21, 2011, when the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard the Terra satellite captured this true-color image. The Canary Islands are a group of seven large islands and several smaller islets, all volcanic in origin. The eastern edge of the chain lies only 100 kilometers from the coasts of Morocco and Western Sahara, and the chain stretches for about 500 kilometers across the Atlantic. All the islands are mountainous, and Tenerife, the central island in this image is home to Pico de Teinde, the highest peak, which rises 12,198 feet (3,718 meters) above sea level. From east to west, the islands are named Lanzarote, Fuerteventura, Gran Canaria, Tenerife, La Gomera, La Palmera and El <span class="hlt">Hierro</span>. A bright swirl of peacock blue marks the ocean south of El <span class="hlt">Hierro</span>, a stain on the sea from an ongoing eruption of a volcano under the waters. Credit: NASA/GSFC/Jeff Schmaltz/MODIS Land Rapid Response Team NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/18968916','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/18968916"><span>Classification of commercial wines from the Canary Islands (Spain) by chemometric techniques using metallic contents.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Frías, Sergio; Conde, José E; Rodríguez-Bencomo, Juan J; García-Montelongo, Francisco; Pérez-Trujillo, Juan P</p> <p>2003-02-06</p> <p>Eleven elements, K, Na, Ca, Mg, Fe, Cu, Zn, Mn, Sr, Li and Rb, were determined in dry and sweet wines bearing the denominations of origin of El <span class="hlt">Hierro</span>, La Palma and Lanzarote islands (Canary Islands, Spain). Analyses were performed by flame atomic absorption spectrophotometry, with the exceptions of lithium and rubidium for which flame atomic emission spectrophotometry was used. Sweet wines from La Palma were elaborated as naturally sweet with over-ripe grapes and significant differences were found in all the analysed elements with the exceptions of sodium, iron and rubidium with regard to dry wines from the same island. Contrarily, sweet wines from Lanzarote elaborated with grapes in a similar ripening state to dry wines did not present significant differences between them with the exception of strontium, the content of which was greater in dry wines. Among the three islands, significant differences in mean content were found with the exceptions of iron and copper. Cluster analysis and principal component analysis show differences in wines according to the island of origin and the ripening state of the grapes. Linear discriminant analysis using rubidium, sodium, manganese and strontium, the four most discriminant elements, gave 100% recognition ability and 95.6% prediction ability. The sensitivity and specificity obtained using soft independent modelling of class analogy (SIMCA) as a modelling multivariate technique were both 100% for El <span class="hlt">Hierro</span> and Lanzarote, and 100 and 95%, respectively, for La Palma. The modelling and discriminant capacities of the different metals were also studied.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23267005','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23267005"><span>Phylogeography and seed dispersal in islands: the case of Rumex bucephalophorus subsp. canariensis (Polygonaceae).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Talavera, María; Navarro-Sampedro, Laura; Ortiz, Pedro L; Arista, Montserrat</p> <p>2013-02-01</p> <p>Rumex bucephalophorus subsp. canariensis is an endemic taxon to Macaronesia with diaspore polymorphism. The origin and colonizing route of this taxon in Macaronesia was studied using molecular data and information on diaspore types. Amplified fragment length polymorphism (AFLP) was used in 260 plants from 22 populations of R. bucephalophorus subsp. canariensis, four from the Madeiran archipelago and 18 from the Canary archipelago. Diaspore production was analysed in 9-50 plants from each population used for AFLP analysis. One hundred and one plants from the Madeiran archipelago and 375 plants from the Canary Islands were studied. For each plant the type of diaspore produced was recorded. Overall populations had low genetic diversity but they showed a geographical pattern of genetic diversity that was higher in the older eastern islands than in the younger western ones. Two types of dispersible diaspores were found: in the eastern Canary islands (Lanzarote, Fuerteventura and Gran Canaria), plants produced exclusively long-dispersible diaspores, whereas in the western Canary islands (Tenerife, La Gomera, El <span class="hlt">Hierro</span>) and the Madeiran archipelago plants produced exclusively short-dispersible diaspores. Genetically, the studied populations fell into four main island groups: Lanzarote-Fuerteventura, Gran Canaria, Tenerife-El <span class="hlt">Hierro</span> and La Gomera-Madeira archipelago. A Moroccan origin of R. bucephalophorus subsp. canariensis is hypothesized with a colonization route from the eastern to the western islands. In addition, at least one gene flow event from La Gomera to the Madeiran archipelago has taken place. During the colonization process the type of dispersible diaspore changed so that dispersability decreased in populations of the westernmost islands.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70016446','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70016446"><span>Large landslides from oceanic volcanoes</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Holcomb, R.T.; Searle, R.C.</p> <p>1991-01-01</p> <p>Large landslides are ubiquitous around the submarine flanks of Hawaiian volcanoes, and GLORIA has also revealed large landslides offshore from Tristan da Cunha and El <span class="hlt">Hierro</span>. On both of the latter islands, steep flanks formerly attributed to tilting or marine erosion have been reinterpreted as landslide headwalls mantled by younger lava flows. These landslides occur in a wide range of settings and probably represent only a small sample from a large population. They may explain the large volumes of archipelagic aprons and the stellate shapes of many oceanic volcanoes. Large landslides and associated tsunamis pose hazards to many islands. -from Authors</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3459031','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3459031"><span>On the occurrence of egg masses of the diamond-shaped squid Thysanoteuthis rhombus Troschel, 1857 in the subtropical eastern Atlantic (Canary Islands). A potential commercial species?</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Pérez, Alejandro Escánez; Elena, Rodrigo Riera; González, Ángel Francisco González; Sierra, Ángel Guerra</p> <p>2012-01-01</p> <p>Abstract Data on opportunistic sightings of diamond-shaped squid Thysanoteuthis rhombus egg masses in the Canary Islands (Atlantic Ocean) are presented. A total of 16 egg masses of this species were recorded and photographed from 2000 to 2010 around the western islands of the archipelago (El <span class="hlt">Hierro</span>, Tenerife and La Gomera). These data reveal the existence of an important spawning area for diamond-shaped squid around the Canary Islands, in subtropical east Atlantic waters. We provide preliminary data for the potential development of an artisanal fishery focused on this species, and a discussion on its potential impacts on the marine ecosystem. PMID:23129987</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED425794.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED425794.pdf"><span>El proceso hacia la integracion de la equidad <span class="hlt">por</span> genero al curriculo.(The Process of the Integration of Gender Equity in the Curriculum.)</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Rivera-Bermudez, Carmen D.</p> <p></p> <p>"El Proyecto Colaborativo de Equidad <span class="hlt">por</span> Genero en la Educacion," or the Collaborative Project for Gender Equity in Education, was undertaken in Puerto Rico between 1990 and 1992 to study how to facilitate the integration of gender equity themes in the curriculum through the direct action of participating teachers. A study examined the…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16622217','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16622217"><span>Protection by meningococcal outer membrane protein <span class="hlt">Por</span>A-specific antibodies and a serogroup B capsular polysaccharide-specific antibody in complement-sufficient and C6-deficient infant rats.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Toropainen, Maija; Saarinen, Leena; Vidarsson, Gestur; Käyhty, Helena</p> <p>2006-05-01</p> <p>The relative contributions of antibody-induced complement-mediated bacterial lysis and antibody/complement-mediated phagocytosis to host immunity against meningococcal infections are currently unclear. Further, the in vivo effector functions of antibodies may vary depending on their specificity and Fc heavy-chain isotype. In this study, a mouse immunoglobulin G2a (mIgG2a) monoclonal antibody (MN12H2) to meningococcal outer membrane protein <span class="hlt">Por</span>A (P1.16), its human IgG subclass derivatives (hIgG1 to hIgG4), and an mIgG2a monoclonal antibody (Nmb735) to serogroup B capsular polysaccharide (B-PS) were evaluated for passive protection against meningococcal serogroup B strain 44/76-SL (B:15:P1.7,16) in an infant rat infection model. Complement component C6-deficient (PVG/c-) rats were used to assess the importance of complement-mediated bacterial lysis for protection. The <span class="hlt">Por</span>A-specific parental mIgG2a and the hIgG1 to hIgG3 derivatives all induced efficient bactericidal activity in vitro in the presence of human or infant rat complement and augmented bacterial clearance in complement-sufficient HsdBrlHan:WIST rats, while the hIgG4 was unable to do so. In C6-deficient PVG/c- rats, lacking complement-mediated bacterial lysis, the augmentation of bacterial clearance by <span class="hlt">Por</span>A-specific mIgG2a and hIgG1 antibodies was impaired compared to that in the syngeneic complement-sufficient PVG/c+ rat strain. This was in contrast to the case for B-PS-specific mIgG2a, which conferred similar protective activity in both rat strains. These data suggest that while anti-B-PS antibody can provide protection in the infant rats without membrane attack complex formation, the protection afforded by anti-<span class="hlt">Por</span>A antibody is more dependent on the activation of the whole complement pathway and subsequent bacterial lysis.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3555536','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3555536"><span>Phylogeography and seed dispersal in islands: the case of Rumex bucephalophorus subsp. canariensis (Polygonaceae)</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Talavera, María; Navarro-Sampedro, Laura; Ortiz, Pedro L.; Arista, Montserrat</p> <p>2013-01-01</p> <p>Background and Aims Rumex bucephalophorus subsp. canariensis is an endemic taxon to Macaronesia with diaspore polymorphism. The origin and colonizing route of this taxon in Macaronesia was studied using molecular data and information on diaspore types. Methods Amplified fragment length polymorphism (AFLP) was used in 260 plants from 22 populations of R. bucephalophorus subsp. canariensis, four from the Madeiran archipelago and 18 from the Canary archipelago. Diaspore production was analysed in 9–50 plants from each population used for AFLP analysis. One hundred and one plants from the Madeiran archipelago and 375 plants from the Canary Islands were studied. For each plant the type of diaspore produced was recorded. Key Results Overall populations had low genetic diversity but they showed a geographical pattern of genetic diversity that was higher in the older eastern islands than in the younger western ones. Two types of dispersible diaspores were found: in the eastern Canary islands (Lanzarote, Fuerteventura and Gran Canaria), plants produced exclusively long-dispersible diaspores, whereas in the western Canary islands (Tenerife, La Gomera, El <span class="hlt">Hierro</span>) and the Madeiran archipelago plants produced exclusively short-dispersible diaspores. Genetically, the studied populations fell into four main island groups: Lanzarote–Fuerteventura, Gran Canaria, Tenerife–El <span class="hlt">Hierro</span> and La Gomera–Madeira archipelago. Conclusions A Moroccan origin of R. bucephalophorus subsp. canariensis is hypothesized with a colonization route from the eastern to the western islands. In addition, at least one gene flow event from La Gomera to the Madeiran archipelago has taken place. During the colonization process the type of dispersible diaspore changed so that dispersability decreased in populations of the westernmost islands. PMID:23267005</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015PhDT.......163T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015PhDT.......163T"><span>Seguridad del paciente en Radioterapia Intraoperatoria: Impacto de los elementos controlados <span class="hlt">por</span> el Radiofisico</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Tarjuelo, Juan Lopez</p> <p></p> <p>Introduccion: En la administracion de la radioterapia intervienen profesionales y equipos de tratamiento, <span class="hlt">por</span> lo que existe el riesgo de error y se precisa que dicho equipamiento funcione conforme a lo esperado. A los radiofisicos les corresponde participar en las actividades de garantia o aseguramiento de la calidad, incluyendo el control de calidad de los equipos, y en la evaluacion de los riesgos asociados. La radioterapia intraoperatoria (RIO) es una tecnica radioterapica de intensificacion de dosis, altamente selectiva, dirigida a volumenes anatomicos restringidos durante el tratamiento quirurgico oncologico, basada en la administracion de una dosis absorbida alta <span class="hlt">por</span> medio de un haz de electrones tras el examen visual directo del lecho tumoral. Como incorporar los ultimos avances en el refuerzo de la seguridad en radioterapia es una tarea ambiciosa y compleja, resulta mas concreta y de inmediata aplicacion su introduccion en la RIO. El objetivo es analizar los elementos que reducen los riesgos y aumentan la seguridad en la RIO y su dosimetria, y valorar la funcion del radiofisico en esta labor. Material y metodos: Se emplearon el planificador Radiance de GMV y el acelerador lineal de los tratamientos de RIO Elekta Precise, controlado con el verificador diario de haces Daily QA Check 1090 y medido con las camaras de ionizacion PPC 40, FC65-G y FC65-P de PTW-Freiburg, a su vez verificadas con fuentes radiactivas adecuadas de estroncio-90 modelos CDP y CDC de IBA Dosimetry. Se realizo un analisis de modos de fallo y efectos (failure mode and effect analysis, FMEA) con el fin de identificar los elementos que forman la RIO y aplicar las herramientas necesarias para la minimizacion de los riesgos y la mejora de la seguridad en la tecnica. Se estudiaron las verificaciones diarias de dicho acelerador Precise con el control estadistico de procesos (statistical process control, SPC) y se simularon intervenciones para devolverlo al estado llamado en control. El SPC</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22004804-fabrication-por-si-sno-sub-nanocomposite-layers-gas-microsensors-nanosensors','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22004804-fabrication-por-si-sno-sub-nanocomposite-layers-gas-microsensors-nanosensors"><span>Fabrication of <span class="hlt">por</span>-Si/SnO{sub x} nanocomposite layers for gas microsensors and nanosensors</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Bolotov, V. V., E-mail: bolotov@obisp.oscsbras.ru; Korusenko, P. M.; Nesov, S. N.</p> <p>2011-05-15</p> <p>Two-phase nanocomposite layers based on porous silicon and nonstoichiometric tin oxide were fabricated by various methods. The structure, as well as elemental and phase composition, of the obtained nanocomposites were studied using transmission and scanning electron microscopy, Raman spectroscopy, Auger electron spectroscopy, and X-ray photoelectron spectroscopy. The results obtained confirm the formation of nanocomposite layers with a thickness as large as 2 {mu}m thick and SnO{sub x} stoichiometry coefficients x = 1.0-2.0. Significant tin diffusion into the porous silicon matrix with D{sub eff} Almost-Equal-To 10{sup -14} cm{sup 2} s{sup -1} was observed upon annealing at 770 K. Test sensor structuresmore » based on <span class="hlt">por</span>-Si/SnO{sub x} nanocomposite layers grown by magnetron deposition showed fairly high stability of properties and sensitivity to NO{sub 2}.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27680045','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27680045"><span>Indicators of health and safety among institutionalized older adults.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cavalcante, Maria Lígia Silva Nunes; Borges, Cíntia Lira; Moura, Acácia Maria Figueiredo Torres de Melo; Carvalho, Rhanna Emanuela Fontenele Lima de</p> <p>2016-01-01</p> <p>To identify the incidence of mortality, diarrheal diseases, scabies and falls; and the prevalence of pressure ulcers - all of which are related to the safety ofinstitutionalized older adults. This was a documentary retrospective study developed in a long-term residential careinstitution for older adults in the Northeast region of Brazil. The data were gathered from records of health assessment indicators filed between January 2008 and December 2015. Analysis included absolute case frequency; the sum of monthly prevalence and incidence rates; mean values of cases; and mean annual incidence and prevalence rates. The incidence of mortality over these nine years ranged from 9% to 13%; of acute diarrheic disease from 13% to 45%; and scabies from 21% to 63%. The prevalence of pressure ulcers ranged from 8% to 23%. Between 2012 and 2015, the incidence rate of falls without injury varied from 38% to 83%, and with injury from12% to 20%. Analysis of the health indicators revealeda high incidence of scabies and falls and a high prevalence of pressure ulcers. The identification of less than optimal rates for performance indicators canhelp improve the quality of nursing care. Identificar a incidência de mortalidade, doenças diarreicas, escabiose e quedas, e a prevalência de lesões <span class="hlt">por</span> pressão para a segurança do idoso institucionalizado. Estudo documental, retrospectivo desenvolvido em uma Instituição de Longa Permanência para Idosos, localizada no nordeste do Brasil. Os dados foram coletados <span class="hlt">por</span> meio dos registros dos indicadores de avaliação de saúde, arquivados de janeiro de 2008 a dezembro de 2015. A análise incluiu a frequência absoluta dos casos; o somatório das taxas de prevalência e incidência mensais; a média de casos e das taxas de incidência e prevalência anuais. Observa-se que a incidência de óbitos nos nove anos considerados variou de 9 a 13%; de doenças diarreicas <span class="hlt">agudas</span>, de 13 a 45%; e de escabiose, de 21 a 63%. A prevalência de lesão <span class="hlt">por</span></p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li class="active"><span>11</span></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_11 --> <div id="page_12" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li class="active"><span>12</span></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="221"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2000HydJ....8..161S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2000HydJ....8..161S"><span>Stratigraphic and geochemical controls on naturally occurring arsenic in groundwater, eastern Wisconsin, USA</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Schreiber, M. E.; Simo, J. A.; Freiberg, P. G.</p> <p></p> <p> pyrite et dans les sulfates dissous et la corrélation entre les concentrations en sulfates, en fer et en arsenic dissous laissent penser que l'oxydation des sulfures est le processus dominant contrôlant la libération de l'arsenic dans les eaux souterraines. Cependant, les oxy-hydroxydes contenant de l'arsenic sont susceptibles d'être une autre source d'arsenic si des conditions réductrices apparaissent ou s'ils sont transportés dans l'aquifère sous forme de colloïdes. L'analyse des données provenant de puits montre que l'intersection entre le SCH et les niveaux statiques des puits domestiques est fortement corrélée à de fortes concentrations en arsenic dans les eaux souterraines. Des données de terrain et de laboratoire conduisent à penser que la contamination en arsenic la plus forte est causée par l'interaction localisée aux forages entre l'air, l'eau et les sulfures. Bien que la contamination en arsenic soit causée par l'oxydation de sulfures présents naturellement, elle est influencée par les fluctuations du niveau piézométrique causées par les pompages du captage municipal ou par les variations climatiques, ce qui peut conduire au déplacement des zones géographiques où se produisent les contaminations. Resumen Se han medido concentraciones de arsénico muy altas (de hasta 12000μg/L) en las aguas subterráneas de un acuífero confinado, en areniscas, localizado en la parte oriental de Wisconsin (EEUU). La fuente principal de arsénico es un horizonte de cementación secundaria (SCH) con un alto contenido en sulfuros, y con una gran variabilidad en espesor, morfología y concentraciones de As. El arsénico aparece en piritas y marcasitas, además de en oxihidróxidos de <span class="hlt">hierro</span>, pero no como una fase independiente de arsenopiritas. El hecho que la marca isotópica de piritas y sulfatos disueltos sea muy similar, y que exista una gran correlación entre las concentraciones de sulfato disuelto, <span class="hlt">hierro</span> y arsénico sugiere que la oxidación de</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/7660660','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/7660660"><span>Being a mother and a <span class="hlt">por</span> día domestic worker. Companionship and deprivation.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bernal, P; Meleis, A I</p> <p>1995-08-01</p> <p>This article presents qualitative findings concerning women's maternal roles, based on interviews conducted in a study on role integration and health, in a Colombian sample of 60 women who are "<span class="hlt">por</span> día" domestic workers. The results describe the women's worldview as they discuss the stresses and the satisfactions of their mothering roles. The results also include the coping strategies used to deal with the stresses inherent in the maternal role. Women describe how the companionship of their children, watching their children grow, and the nurturing they give their children provides them with pride and deep satisfaction. These satisfying aspects of their role are burdened by the stress related to worry about children's bad behavior, their illness, and a pervasive generalized sense of constant worry. Being single parents adds more stress to these women's lives. Participants coped emotionally through distraction and through talking with friends. Other coping strategies included calming self, problem solving, talking with children, and substance use. The authors conclude with a discussion of the relationship between poverty and work situation as contexts for understanding maternal roles.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015E%26PSL.431..140K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015E%26PSL.431..140K"><span>Deep intrusions, lateral magma transport and related uplift at ocean island volcanoes</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Klügel, Andreas; Longpré, Marc-Antoine; García-Cañada, Laura; Stix, John</p> <p>2015-12-01</p> <p>Oceanic intraplate volcanoes grow by accumulation of erupted material as well as by coeval or discrete magmatic intrusions. Dykes and other intrusive bodies within volcanic edifices are comparatively well studied, but intrusive processes deep beneath the volcanoes remain elusive. Although there is geological evidence for deep magmatic intrusions contributing to volcano growth through uplift, this has rarely been demonstrated by real-time monitoring. Here we use geophysical and petrological data from El <span class="hlt">Hierro</span>, Canary Islands, to show that intrusions from the mantle and subhorizontal transport of magma within the oceanic crust result in rapid endogenous island growth. Seismicity and ground deformation associated with a submarine eruption in 2011-2012 reveal deep subhorizontal intrusive sheets (sills), which have caused island-scale uplift of tens of centimetres. The pre-eruptive intrusions migrated 15-20 km laterally within the lower oceanic crust, opening pathways that were subsequently used by the erupted magmas to ascend from the mantle to the surface. During six post-eruptive episodes between 2012 and 2014, further sill intrusions into the lower crust and upper mantle have caused magma to migrate up to 20 km laterally, resulting in magma accumulation exceeding that of the pre-eruptive phase. A comparison of geobarometric data for the 2011-2012 El <span class="hlt">Hierro</span> eruption with data for other Atlantic intraplate volcanoes shows similar bimodal pressure distributions, suggesting that eruptive phases are commonly accompanied by deep intrusions of sills and lateral magma transport. These processes add significant material to the oceanic crust, cause uplift, and are thus fundamentally important for the growth and evolution of volcanic islands. We suggest that the development of such a magma accumulation zone in the lower oceanic crust begins early during volcano evolution, and is a consequence of increasing size and complexity of the mantle reservoir system, and potentially</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24587269','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24587269"><span>Pronounced fixation, strong population differentiation and complex population history in the Canary Islands blue tit subspecies complex.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hansson, Bengt; Ljungqvist, Marcus; Illera, Juan-Carlos; Kvist, Laura</p> <p>2014-01-01</p> <p>Evolutionary molecular studies of island radiations may lead to insights in the role of vicariance, founder events, population size and drift in the processes of population differentiation. We evaluate the degree of population genetic differentiation and fixation of the Canary Islands blue tit subspecies complex using microsatellite markers and aim to get insights in the population history using coalescence based methods. The Canary Island populations were strongly genetically differentiated and had reduced diversity with pronounced fixation including many private alleles. In population structure models, the relationship between the central island populations (La Gomera, Tenerife and Gran Canaria) and El <span class="hlt">Hierro</span> was difficult to disentangle whereas the two European populations showed consistent clustering, the two eastern islands (Fuerteventura and Lanzarote) and Morocco weak clustering, and La Palma a consistent unique lineage. Coalescence based models suggested that the European mainland forms an outgroup to the Afrocanarian population, a split between the western island group (La Palma and El <span class="hlt">Hierro</span>) and the central island group, and recent splits between the three central islands, and between the two eastern islands and Morocco, respectively. It is clear that strong genetic drift and low level of concurrent gene flow among populations have shaped complex allelic patterns of fixation and skewed frequencies over the archipelago. However, understanding the population history remains challenging; in particular, the pattern of extreme divergence with low genetic diversity and yet unique genetic material in the Canary Island system requires an explanation. A potential scenario is population contractions of a historically large and genetically variable Afrocanarian population, with vicariance and drift following in the wake. The suggestion from sequence-based analyses of a Pleistocene extinction of a substantial part of North Africa and a Pleistocene/Holocene eastward</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3937385','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3937385"><span>Pronounced Fixation, Strong Population Differentiation and Complex Population History in the Canary Islands Blue Tit Subspecies Complex</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Hansson, Bengt; Ljungqvist, Marcus; Illera, Juan-Carlos; Kvist, Laura</p> <p>2014-01-01</p> <p>Evolutionary molecular studies of island radiations may lead to insights in the role of vicariance, founder events, population size and drift in the processes of population differentiation. We evaluate the degree of population genetic differentiation and fixation of the Canary Islands blue tit subspecies complex using microsatellite markers and aim to get insights in the population history using coalescence based methods. The Canary Island populations were strongly genetically differentiated and had reduced diversity with pronounced fixation including many private alleles. In population structure models, the relationship between the central island populations (La Gomera, Tenerife and Gran Canaria) and El <span class="hlt">Hierro</span> was difficult to disentangle whereas the two European populations showed consistent clustering, the two eastern islands (Fuerteventura and Lanzarote) and Morocco weak clustering, and La Palma a consistent unique lineage. Coalescence based models suggested that the European mainland forms an outgroup to the Afrocanarian population, a split between the western island group (La Palma and El <span class="hlt">Hierro</span>) and the central island group, and recent splits between the three central islands, and between the two eastern islands and Morocco, respectively. It is clear that strong genetic drift and low level of concurrent gene flow among populations have shaped complex allelic patterns of fixation and skewed frequencies over the archipelago. However, understanding the population history remains challenging; in particular, the pattern of extreme divergence with low genetic diversity and yet unique genetic material in the Canary Island system requires an explanation. A potential scenario is population contractions of a historically large and genetically variable Afrocanarian population, with vicariance and drift following in the wake. The suggestion from sequence-based analyses of a Pleistocene extinction of a substantial part of North Africa and a Pleistocene/Holocene eastward</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27556875','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27556875"><span>Pain from the life cycle perspective: Evaluation and Measurement through psychophysical methods of category estimation and magnitude estimation.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sousa, Fátima Aparecida Emm Faleiros; Silva, Talita de Cássia Raminelli da; Siqueira, Hilze Benigno de Oliveira Moura; Saltareli, Simone; Gomez, Rodrigo Ramon Falconi; Hortense, Priscilla</p> <p>2016-08-18</p> <p>to describe acute and chronic pain from the perspective of the life cycle. participants: 861 people in pain. The Multidimensional Pain Evaluation Scale (MPES) was used. in the category estimation method the highest descriptors of chronic pain for children/ adolescents were "Annoying" and for adults "Uncomfortable". The highest descriptors of acute pain for children/adolescents was "Complicated"; and for adults was "Unbearable". In magnitude estimation method, the highest descriptors of chronic pain was "Desperate" and for descriptors of acute pain was "Terrible". the MPES is a reliable scale it can be applied during different stages of development. descrever a dor <span class="hlt">aguda</span> e a crônica na perspectiva do ciclo vital. Métodos: participaram 861 pessoas com dor. Foi utilizada a Escala Multidimensional de Avaliação da Dor (EMADOR). Resultados: no método da estimação de categoria o descritor da dor crônica de maior atribuição para crianças e adolescentes foi "Chata" e para adultos foi "Desconfortável". Os descritores de maior atribuição para dor <span class="hlt">aguda</span> em crianças e adolescentes foram "Complicada" e em adultos "Insuportável". No método de estimação de magnitude, o descritor de maior atribuição na dor crônica foi "Atormentadora" e na dor <span class="hlt">aguda</span> foi "Terrível". a EMADOR é uma escala confiável e pode ser utilizada nas diferentes etapas do desenvolvimento humano. la descripción del dolor agudo y crónico desde las perspectiva del ciclo de vida. participaron 861 personas con dolor. Se utilizó la Escala Multidimensional de Evaluación del Dolor (EMEDOR). en el método de estimación de categoría el descriptor de dolor crónico más alto para niños y adolescentes fue de Molesto y para adultos fue Incómodo. Los descriptores mayores de dolor agudo para niños y adolescentes fueron Complejo y para adultos Insoportable. En el método de estimación de magnitud, el mayor descriptor de dolor crónico fueron Atormentador y el mayor de dolor agudo fue Terrible</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20809646','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20809646"><span>Dietary intake of aluminum in a Spanish population (Canary Islands).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>González-Weller, Dailos; Gutiérrez, Angel José; Rubio, Carmen; Revert, Consuelo; Hardisson, Arturo</p> <p>2010-10-13</p> <p>The aim of this study was to analyze the aluminum content in foods and beverages most commonly consumed by the Canary Island population to determine the dietary intake of this metal throughout the Canary Islands as a whole and in each of the seven islands (Gran Canaria, Lanzarote, Fuerteventura, Tenerife, La Palma, La Gomera, and El <span class="hlt">Hierro</span>). Four hundred and forty samples were analyzed by ICP-OES. Estimated total intake of aluminum for the Canary population was 10.171 mg/day, slightly higher than the provisional tolerable weekly intake (PTWI; 10 mg/day for a person weighing 70 kg). Aluminum intake by age and sex of the Canary Island population was also determined and compared values from other populations, both national and international.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4262527','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4262527"><span>Aquisição fonológica do português brasileiro <span class="hlt">por</span> crianças ouvintes bilíngues bimodais e surdas usuárias de implante coclear</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Cruz, Carina Rebello; Finger, Ingrid</p> <p>2014-01-01</p> <p>Resumo O presente estudo investiga a aquisição fonológica do Português Brasileiro (PB) <span class="hlt">por</span> 24 crianças ouvintes bilíngues bimodais, com acesso irrestrito à Língua Brasileira de Sinais (Libras), e <span class="hlt">por</span> 6 crianças surdas que utilizam implante coclear (IC), com acesso restrito ou irrestrito à Libras. Para a avaliação do sistema fonológico das crianças em PB, foi utilizada a Parte A, Prova de Nomeação, do ABFW – Teste de Linguagem Infantil (ANDRADE et al. 2004). Os resultados revelaram que as crianças ouvintes bilíngues bimodais e a criança surda usuária de IC com acesso irrestrito à Libras apresentaram processo de aquisição fonológica esperada (normal) para a sua faixa etária. Considera-se que a aquisição precoce e o acesso irrestrito à Libras podem ter sido determinantes para o desempenho dessas crianças no teste oral utilizado. PMID:25506105</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUFMNG12A..09M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUFMNG12A..09M"><span>Volcanic Seismicity - The Power of the b-value</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Main, I. G.; Roberts, N.; Bell, A. F.</p> <p>2016-12-01</p> <p>The Gutenberg-Richter `b-value' is commonly used in volcanic eruption forecasting to infer material or mechanical properties from earthquake distributions. It is `well known' that the b-value tends to be high or very high for volcanic earthquake populations relative to b = 1 for those of tectonic earthquakes, and that b varies significantly with time during periods of unrest. Subject to suitable calibration the b-value also allows us to quantify and characterise earthquake distributions of both ancient and currently-active populations, as a measure of the frequency-size distribution of source rupture area or length. Using a new iterative sampling method (Roberts et al. 2016), we examine data from the El <span class="hlt">Hierro</span> seismic catalogue during a period of unrest in 2011-2013, and quantify the resulting uncertainties. The results demonstrate commonly-applied methods of assessing uncertainty in b-value significantly underestimate the total uncertainty, particularly when b is high. They also show clear multi-modal behaviour in the evolution of the b-value. Individual modes are relatively stable in time, but the most probable b-value intermittently switches between modes, one of which is similar to that of tectonic seismicity, and some are genuinely higher within the total error. A key benefit of this approach is that it is able to resolve different b-values associated with contemporaneous processes, even in the case where some generate high rates of events for short durations and others low rates for longer durations. These characteristics that are typical for many volcanic processes. Secondly, we use a range field observations from the exhumed extinct magma chamber on the Isle of Rum, NW Scotland, to infer an equivalent a b-value for the `frozen' fracture system that would have been active at the time of volcanism 65Ma ago. Using measurements from millimetre-scale fractures to lineation's on satellite imagery over 100m in length, we estimate b=1.8, significantly greater than</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFMDI51B0309B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFMDI51B0309B"><span>Isotopic composition of reduced and oxidized sulfur in the Canary Islands: implications for the mantle S cycle</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Beaudry, P.; Longpre, M. A.; Wing, B. A.; Bui, T. H.; Stix, J.</p> <p>2017-12-01</p> <p>The Earth's mantle contains distinct sulfur reservoirs, which can be probed by sulfur isotope analyses of volcanic rocks and gases. We analyzed the isotopic composition of reduced and oxidized sulfur in a diverse range of volcanically derived materials spanning historical volcanism in the Canary Islands. Our sample set consists of subaerial volcanic tephras from three different islands, mantle and sedimentary xenoliths, as well as lava balloon samples from the 2011-2012 submarine El <span class="hlt">Hierro</span> eruption and associated crystal separates. This large sample set allows us to differentiate between the various processes responsible for sulfur isotope heterogeneity in the Canary archipelago. Our results define an array in triple S isotope space between the compositions of the MORB and seawater sulfate reservoirs. Specifically, the sulfide values are remarkably homogeneous around d34S = -1 ‰ and D33S = -0.01 ‰, while sulfate values peak at d34S = +4 ‰ and D33S = +0.01 ‰. Lava balloons from the El <span class="hlt">Hierro</span> eruption have highly enriched sulfate d34S values up to +19.3 ‰, reflecting direct interaction between seawater sulfate and the erupting magma. Several sulfate data points from the island of Lanzarote also trend towards more positive d34S up to +13.8 ‰, suggesting interaction with seawater sulfate-enriched lithologies or infiltration of seawater within the magmatic system. On the other hand, the modal values and relative abundances of S2- and S6+ in crystal separates suggest that the Canary Island mantle source has a d34S around +3 ‰, similar to the S-isotopic composition of a peridotite xenolith from Lanzarote. We infer that the S2- and S6+ modes reflect isotopic equilibrium between those species in the magmatic source, which requires 80 % of the sulfide to become oxidized after melting, consistent with measured S speciation. This 34S enrichment of the source could be due to the recycling of hydrothermally-altered oceanic crust, which has been previously suggested</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUFM.V14A..06G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUFM.V14A..06G"><span>Eruptive Dynamics Inferred from Textural Analysis of Ash Time Series: The 2015 Reawakening of Cotopaxi Volcano</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gaunt, H. E.; Bernard, B.; Hidalgo, S.; Proaño, A.; Wright, H. M. N.; Mothes, P. A.; Criollo, E.</p> <p>2016-12-01</p> <p>The eruptive process that took place in October 2011 in the submarine volcano Tagoro off the Island of El <span class="hlt">Hierro</span> (Canary Island) and the subsequent degasification stage, five months later, have increased the concentration of TdFe(II) (Total dissolved iron(II)) in the waters nearest to the volcanic edifice. In order to detect any variation in concentrations of TdFe(II) due to hydrothermal emissions, three cruises were carried out two years after the eruptive process in October 2013, March 2014, May 2015, March 2016 and November 2016. The results from these cruises confirmed important positive anomalies in TdFe(II), which coincided with negatives anomalies in pHF,is (pH in free scale, at in situ conditions) located in the proximity of the main cone. Maximum values in TdFe(II) both at the surface, associated to chlorophyll a maximum, and at the sea bottom, were also observed, showing the important influence of organic complexation and particle re-suspension processes. Temporal variability studies were carried out over periods ranging from hours to days in the stations located over the main and two secondary cones in the volcanic edifice with positive anomalies in TdFe(II) concentrations and negative anomalies in pHF,is values. Observations showed an important variability in both pHF,is and TdFe(II) concentrations, which indicated the volcanic area was affected by a degasification process that remained in the volcano after the eruptive phase had ceased. Fe(II) oxidation kinetic studies were also undertaken in order to analyze the effects of the seawater properties in the proximities of the volcano on the oxidation rate constants and t1/2 (half-life time) of ferrous iron. The increased TdFe(II) concentrations and the low associated pHF,is values acted as an important fertilization event in the seawater around the Tagoro volcano at the Island of El <span class="hlt">Hierro</span> providing optimal conditions for the regeneration of the area.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19084424','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19084424"><span>Profitability of our lung retrieval program from non heart beating donors.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Fernández, Elena; Calatayud, Joaquín; Jarabo, José Ramón; Hernando, Florentino; Rodríguez, Olga; Gómez, Ana María; Soria, Ana; Del Río, Francisco</p> <p>2009-02-01</p> <p>In 2002 the first lung transplant from non heart beating (NHB) donors took place in Madrid. The objective of this study was to analyse our Maastricht type I NHB lung donors retrieval program and to check out its profitability. Based on the NHB lung donors retrieval program carried out at Hospital Clínico San Carlos (Madrid) in association with Hospital Puerta de <span class="hlt">Hierro</span> (Madrid), all lung donors from the beginning of the program from June 2002 to December 2006 have been analysed. When faced with a case of sudden death, advanced life support manoeuvres are initiated before 15 min. If the patient meets a given set of criteria, code 0/9 is activated. Arrival time to the hospital cannot exceed 90 min. Femoral artery and vein are cannulated, extracorporeal circulation is started and lungs are preserved. After the relatives' and judicial authorisation lungs are retrieved. Out of a total of 322 occurrences of code 0/9, 43 lung retrievals and 25 implants were reported. A total of 95% of donors were male, with an average age of 41 years and 91% with blood group A or O. 2004 saw the highest number of retrievals (14). January, May and December showed the highest number of retrievals. Incidence of sudden deaths was higher from 7 to 10 a.m. and from 7 to 10 p.m. Twenty-three implants at Hospital Puerta de <span class="hlt">Hierro</span> and three more at Hospital Marqués de Valdecilla (Santander) were reported. A considerable amount of preserved lungs, valid for transplant, were not retrieved because of a lack of an appropriate recipient at the time. A total of 58.1% of preserved lungs were implanted. The ratio of obtained lungs was 11.4% of actual donors and 7.7% of total occurrences. However, this percentage could have been higher if we take into account the number of valid lungs that were not transplanted because of the lack of recipients.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28802962','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28802962"><span>A skeletal case of hypertrophic osteoarthropathy from the Canary Islands dating from 1000 BP.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>González-Reimers, Emilio; Trujillo-Mederos, Aioze; Machado-Calvo, Manuel; Castañeyra-Ruiz, María; Ordóñez, Alejandra C; Arnay-de-la-Rosa, Matilde</p> <p>2015-12-01</p> <p>A left tibia, the distal right tibia, and the proximal four fifths of the right ulna and radius, probably belonging to an adult prehispanic man (antiquity of ≈1000 years BP) were found among commingled bone remains in a collective burial cave of the island of El <span class="hlt">Hierro</span>, in the Canary Archipelago. All four bones show an intense periosteal bone formation, encrusting the preserved cortical bone of the diaphyses. Differential diagnosis include melorheostosis, syphilis, and leprosy, although the most likely diagnosis is hypertrophic osteoarthropathy, which is usually associated with lung neoplasm or non-malignant diseases leading to chronic hypoxemia. The marked bone proliferation, possibly due to a chronic condition, suggests that possibly the underlying illness was a non-malignant one. Copyright © 2015 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28538760','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28538760"><span>A Multivariate Model for Prediction of Obstructive Coronary Disease in Patients with Acute Chest Pain: Development and Validation.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Correia, Luis Cláudio Lemos; Cerqueira, Maurício; Carvalhal, Manuela; Ferreira, Felipe; Garcia, Guilherme; Silva, André Barcelos da; Sá, Nicole de; Lopes, Fernanda; Barcelos, Ana Clara; Noya-Rabelo, Márcia</p> <p>2017-04-01</p> <p>ça arterial coronariana (DAC) com base em variáveis avaliadas à admissão na unidade coronariana (UC) devido a dor torácica <span class="hlt">aguda</span>. Foram estudados um total de 470 pacientes, 370 utilizados como amostra de derivação e os subsequentes 100 pacientes como amostra de validação. Como padrão de referência, a angiografia foi necessária para descartar DAC (estenose ≥ 70%), enquanto a angiografia ou um teste não invasivo negativo foi utilizado para confirmar a doença. Foram testadas como preditoras 13 variáveis basais relacionadas à história médica, 14 características de desconforto torácico e oito variáveis relacionadas ao exame físico ou testes laboratoriais. A prevalência de DAC foi de 48%. <span class="hlt">Por</span> regressão logística, seis variáveis permaneceram como preditoras independentes de DAC: idade, gênero masculino, alívio com nitrato, sinais de insuficiência cardíaca, e eletrocardiograma e troponina positivos. A área sob a curva (area under the curve, AUC) deste modelo final foi de 0,80 (intervalo de confiança de 95% [IC95%] = 0,75 - 0,84) na amostra de derivação e 0,86 (IC95% = 0,79 - 0,93) na amostra de validação. O teste de Hosmer-Lemeshow indicou uma boa calibração em ambas as amostras (p = 0,98 e p = 0,23, respectivamente). Em comparação com o modelo básico contendo eletrocardiograma e troponina, o modelo completo ofereceu um incremento na AUC de 0,07 tanto na amostra de derivação (p = 0,0002) quanto na de validação (p = 0,039). A melhoria na discriminação integrada foi de 0,09 nas amostras de derivação (p < 0,001) e validação (p < 0,0015). Um modelo multivariado foi derivado e validado como uma ferramenta acurada para estimar a probabilidade pré-teste de DAC em pacientes com dor torácica <span class="hlt">aguda</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27759787','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27759787"><span>MANAGEMENT OF ACUTE SEVERE ULCERATIVE COLITIS: A CLINICAL UPDATE.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sobrado, Carlos Walter; Sobrado, Lucas Faraco</p> <p>2016-01-01</p> <p> azathioprine. A surgical procedure is indicated for selected cases. A colite <span class="hlt">aguda</span> grave é emergência médica, potencialmente letal e o seu tratamento permanece ainda nos dias de hoje um desafio para o clínico e cirurgião. A corticoterapia intravenosa introduzida no arsenal terapêutico na década de 50 permanece como primeira linha de tratamento, e nos pacientes refratários a tal medida, a terapia de resgate pode ser com medidas clínicas ou colectomia de urgência. Avaliar os resultados da terapia de resgate medicamentosa (ciclosporina, infliximabe e tracolimus), suas indicações e resultados, e sugerir um guia prático para abordagem clínica. Foi realizada revisão na literatura utilizando as bases Medline/Pubmed, Cochrane Library, Scielo, e informações adicionais em sites institucionais de interesse cruzando os descritores: colite <span class="hlt">aguda</span> grave, colite fulminante e tratamento. O tratamento da colite <span class="hlt">aguda</span> grave tem evitado a colectomia em 60- 70% dos casos, desde que iniciado precocemente e com acompanhamento multidisciplinar. A ciclosporina intravenosa apesar de seus efeitos adversos, tem sido indicada naqueles casos mais graves com risco iminente de colectomia, pela sua rapidez de ação, meia-vida curta, e não aumentar os riscos de complicações cirúrgicas. A terapia com infliximabe tem sido reservada para os casos menos graves e naqueles em uso ou já expostos a imunossupressores (AZA/6-MP). A facilidade terapêutica, seus bons resultados a curto e médio prazo, a possibilidade de terapia de manutenção e também <span class="hlt">por</span> agir como "ponte" para ação de imunossupressores (AZA/6-MP) tem recentemente favorecido a indicação de biológicos. A colectomia fica reservada para casos que não apresentaram resposta a terapia de resgate após cinco a sete dias de tratamento e nas complicações (megacólon tóxico, hemorragia profusa e perfuração). s: Os pacientes com boa resposta à terapia de resgate e não submetidos à operações de urgência, deverão ser</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5061630','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5061630"><span>Prevalencia y factores de riesgo para infecciones del tracto urinario de inicio en la comunidad causadas <span class="hlt">por</span> Escherichia coli productor de betalactamasas de espectro extendido en Colombia</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Blanco, Victor M.; Maya, Juan J.; Correa, Adriana; Perenguez, Marcela; Muñoz, Juan S.; Motoa, Gabriel; Pallares, Christian J.; Rosso, Fernando; Matta, Lorena; Celis, Yamile; Garzon, Martha; Villegas, y María V.</p> <p>2016-01-01</p> <p>RESUMEN Introducción Las infecciones del tracto urinario (ITU) son frecuentes en la comunidad. Sin embargo, la información de aislamientos resistentes en este contexto es limitada en Latinoamérica. Este estudio tiene como objetivo determinar la prevalencia y los factores de riesgo asociados con ITU de inicio en la comunidad (ITU-IC) causadas <span class="hlt">por</span> Escherichia coli productor de betalactamasas de espectro extendido (BLEE) en Colombia. Materiales y métodos Entre agosto y diciembre de 2011 se realizó un estudio de casos y controles en 3 instituciones de salud de tercer nivel en Colombia. Se invitó a participar a todos los pacientes admitidos a urgencias con diagnóstico probable de ITU-IC, y se les pidió una muestra de orina. En los aislamien-tos de E. coli se realizaron pruebas confirmatorias para BLEE, susceptibilidad antibiótica, caracterización molecular (PCR en tiempo real para genes bla, repetitive element palindromic PCR [rep-PCR], multilocus sequence typing [MLST] y factores de virulencia <span class="hlt">por</span> PCR). Se obtuvo información clínica y epidemiológica, y posteriormente se realizó el análisis estadístico. Resultados De los 2.124 pacientes seleccionados, 629 tuvieron un urocultivo positivo, en 431 de estos se aisló E. coli, 54 fueron positivos para BLEE y 29 correspondieron a CTX-M-15. La mayoría de los aislamientos de E. coli productor de BLEE fueron sensibles a ertapenem, fosfomicina y amikacina. La ITU complicada se asoció fuertemente con infecciones <span class="hlt">por</span> E. coli productor de BLEE (OR = 3,89; IC 95%: 1,10–13,89; p = 0,03). E. coli productor de CTX-M-15 mostró 10 electroferotipos diferentes; de estos, el 65% correspondieron al ST131. La mayoría de estos aislamientos tuvieron 8 de los 9 factores de virulencia analizados. Discusión E. coli portador del gen blaCTX-M-15 asociado al ST131 sigue siendo frecuente en Colombia. La presencia de ITU-IC complicada aumenta el riesgo de tener E. coli productor de BLEE, lo cual debe tenerse en cuenta para ofrecer</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3923609','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3923609"><span>La inserción en el mercado laboral de los inmigrantes latinos en España y en los Estados Unidos: Diferencias <span class="hlt">por</span> país de origen y estatus legal</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Connor, Phillip; Massey, Douglas</p> <p>2013-01-01</p> <p>Resumen Este artículo compara los resultados económicos entre los inmigrantes latinoamericanos en España y Estados Unidos. Detectamos un efecto de selección <span class="hlt">por</span> el que la mayoría de los inmigrantes latinoamericanos en España proceden de Sudamérica de un entorno de clases medias, mientras la mayoría de los inmigrantes que van a los Estados Unidos son centroamericanos de clase baja. Este efecto de selección explica las diferencias transnacionales en la probabilidad de empleo, logro ocupacional y salarios obtenidos. A pesar de las diferencias en los orígenes y las características de los latinoamericanos en ambos países, los factores demográficos, humanos y de capital social parecen operar de forma similar en ambos países; y cuando los modelos se estiman separadamente <span class="hlt">por</span> estatus legal, descubrimos que los efectos se acentúan más entre los inmigrantes irregulares cuando se los compara con los regulares, especialmente en Estados Unidos. PMID:24532857</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014PhDT.......343M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014PhDT.......343M"><span>"Estudio tribologico de aceros para moldes. Aplicacion al moldeo <span class="hlt">por</span> inyeccion de polibutilentereftalato reforzado con fibra de vidrio"</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Martinez Mateo, Isidoro Jose</p> <p></p> <p>Mould materials for injection moulding of polymers and polymer-matrix composites represent a relevant industrial economic sector due to the large quantity of pieces and components processed. The material selection for mould manufacturing, its composition and heat treatment, the hardening procedures and machining and finishing processes determine the service performance and life of the mould. In the first part of the present study, the relationship between the hardness and microstructure and the wear resistance of mould steels from large blocks has been studied by pin-on-disc tests, studying the main wear mechanisms. In order to determine the surface damage on mould steels under real injection conditions, different commercial steels have been studied by measuring the variation of surface roughness with the number of injected pieces with different reinforcement percentages and different mould geometries, by using optical profilometry and scanning electron microscopy techniques. It was important to determine the variation of surface roughness of the moulded pieces with the number of injection operations. The materials used were polybutyleneterephthalate pure and reinforced with either 20% or 50% glass fibre. For the different mould designs, the evolution of the glass fibre orientation with injection flow has been determined by image analysis and related to roughness changes and surface damage, both of the composite parts and of the mould steel surface. Finally, the abrasion resistance of the composite parts has been studied by scratch tests as a function of the number of injected parts and of the scratch direction with respect to injection flow and glass fibre orientation. Los materiales para moldes de inyeccion de polimeros y materiales compuestos representan un sector economicamente muy relevante debido al gran aumento del numero de componentes fabricados a partir de materiales polimericos obtenidos mediante moldeo <span class="hlt">por</span> inyeccion. La seleccion del material para la</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24401777','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24401777"><span>[Surveillance of Haemophilus influenzae serotypes in Argentina from 2005 to 2010 during the Haemophilus influenzae type b conjugate vaccine era].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Efron, Adriana M; Moscoloni, María A; Reijtman, Vanesa R; Regueira, Mabel</p> <p>2013-01-01</p> <p>The introduction of the Haemophilus influenzae type b vaccine in the immunization programs of many countries has greatly reduced this invasive disease and the carriage caused by this serotype, also increasing other capsular types and non-capsular isolations. There were 313 isolations of H. influenzae under study, which were recovered from a sterile site coming from pediatric and adult patients carrying the invasive disease. Patients were treated at 90 different hospitals belonging to the Red Nacional de Laboratorios para Meningitis e Infecciones Respiratorias <span class="hlt">Agudas</span> Bacterianas (National Lab Network for Meningitis and Acute Bacterial Respiratory Infections) from 2005 to 2010 for the following disorders: pneumonia, 40.3% (n=126), meningitis, 30.0% (n=94) and bacteremia, 26.5% (n=83). In pediatric patients (n=279), the highest frequency of isolations corresponded to children under the age of 2 years, 74.5% (n=208). Regarding type distribution, 61.3% corresponded to non-capsular H. influenzae (n=192), 20.1% to type b (n=63), 11.2% to type a (n=35), 4.8% to type f, and 2.6% to other types. Capsular H. influenzae was predominant in meningitis whereas non-capsular H. influenzae in pneumonia and bacteremia. The biotype was determined in 306 isolations. The totality (100%) of type a (n=35) was biotype II whereas 66.7% of type b (n=63) was biotype I. Slide agglutination and PCR tests were used in 220 isolations. There was a match of 0.982 (IC: 0.92-1.00) between them. During the last year, there was a great increase in type b, showing the importance of clinical and laboratory-based surveillance of the invasive disease caused by H. influenzae. Copyright © 2013 Asociación Argentina de Microbiología. Publicado <span class="hlt">por</span> Elsevier España. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12689798','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12689798"><span>Mujeres felices <span class="hlt">por</span> ser saludables: a breast cancer risk reduction program for Latino women.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Fitzgibbon, Marian L; Gapstur, Susan M; Knight, Sara J</p> <p>2003-05-01</p> <p>Breast cancer is the most commonly diagnosed cancer and the most common cause of cancer mortality among Latino women. Several behavioral factors such as early detection and dietary practices could help decrease morbidity and mortality associated with breast cancer in this population. Unfortunately, there are few data regarding the efficacy of health-related interventions for young Latino women. Mujeres Felices <span class="hlt">por</span> ser Saludables is a randomized intervention project designed to assess breast cancer risk reduction behavior among Latino women ages 20-40 years. The primary objectives of the project were to determine whether an 8-month integrated dietary/breast health intervention could lead to a greater reduction in dietary fat, increase in dietary fiber, increase in the frequency and proficiency of breast self examination (BSE), and reduction in anxiety related to BSE compared to controls. Herein we describe the overall design of the project and present baseline characteristics of the 256 randomized women. Our results suggest that the average daily intake of dietary fat (percentage of total energy) was slightly below 30% (percentage of total energy) among the women randomized. While over half of these women reported that they practice BSE, and few reported anxiety related to BSE, less than 27% of women were proficient in the recommended BSE technique. There are few data on the dietary and breast health behaviors of young low-acculturated Latino women. This study documents the feasibility of recruiting, randomizing, and obtaining both baseline dietary and breast health data on this unique and underserved population.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li class="active"><span>12</span></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_12 --> <div id="page_13" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li class="active"><span>13</span></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="241"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015EGUGA..17.9550J','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015EGUGA..17.9550J"><span>Petrological and geochemical studies of mantle xenoliths from La Palma, Canary Islands</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Janisch, Astrid; Ntaflos, Theodoros</p> <p>2015-04-01</p> <p>La Palma is the second youngest island, after El <span class="hlt">Hierro</span>, of the Canary archipelago. The archipelago consists of seven large islands, forming an east-west-trending island chain, and several seamounts. All together they form a volcanic belt of around 800 km length and 450 km width, which presumably comprises roughly the Canary hotspot. The islands are located off the western coast of Morocco, Africa. The distance ranges from 100 km to 500 km. Concurrently with the distance, subaerial volcanism age progresses from the oldest lava in the east to the youngest in the west of the archipelago. Presently, La Palma is in the shield building stage of growth (alongside with El <span class="hlt">Hierro</span> and Tenerife) and is furthermore the fastest growing island of the Canary archipelago. Historical volcanic eruptions are restricted on the younger islands, La Palma and El <span class="hlt">Hierro</span>, with the last eruption at the south end of La Palma in 1971. Mantle xenoliths described in this work were collected at the slopes of San Antonio Volcano, Fuencaliente, brought to the surface during the 1677/1678 eruption. The mantle xenolith collection comprises sp-lherzolites, sp-harzburgites and pyroxenites. The texture can be distinguished between coarse-grained matrix and fine-grained veins in various thicknesses, mostly with olivine and pyroxene but also with amphibole, phlogopite as well as apatite. Mineral analyses reveal the existence of primary and secondary ol, cpx and opx. Primary ol has Fo contents of 89.2 to 91.7 and NiO ranging from 0.3 to 0.45 wt.%, whereas secondary ol show Fo values of 78.4 to 91.9 but with NiO below 0.3 wt.%. Primary cpx are predominantly Cr-Diopsides with En48.7-51.9-Wo43.5-44.3-Fs4.1-4.9 and Mg# of 91.5 to 92.4. Secondary cpx, primarily Ti-Augit, display En36.7-44.4-Wo47.7-49.6-Fs6.7-13.0 and Mg# of 75.3 to 90.8. Primary opx compositions are in range of En89.3-90.6-Wo1.3-1.5-Fs8.1-9.3 with Mg# between 90.7 and 92.0. Secondary opx exhibit En88.7-89.2-Wo1.7-1.9-Fs9.1-9.5 and Mg# of 90</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23503455','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23503455"><span>Relationship of CYP2D6, CYP3A, <span class="hlt">POR</span>, and ABCB1 genotypes with galantamine plasma concentrations.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Noetzli, Muriel; Guidi, Monia; Ebbing, Karsten; Eyer, Stephan; Zumbach, Serge; Giannakopoulos, Panteleimon; von Gunten, Armin; Csajka, Chantal; Eap, Chin B</p> <p>2013-04-01</p> <p>The frequently prescribed antidementia drug galantamine is extensively metabolized by the enzymes cytochrome P450 (CYP) 2D6 and CYP3A and is a substrate of the P-glycoprotein. We aimed to study the relationship between genetic variants influencing the activity of these enzymes and transporters with galantamine steady state plasma concentrations. In this naturalistic cross-sectional study, 27 older patients treated with galantamine were included. The patients were genotyped for common polymorphisms in CYP2D6, CYP3A4/5, <span class="hlt">POR</span>, and ABCB1, and galantamine steady state plasma concentrations were determined. The CYP2D6 genotype seemed to be an important determinant of galantamine pharmacokinetics, with CYP2D6 poor metabolizers presenting 45% and 61% higher dose-adjusted galantamine plasma concentrations than heterozygous and homozygous CYP2D6 extensive metabolizers (median 2.9 versus 2.0 ng/mL · mg, P = 0.025, and 1.8 ng/mL · mg, P = 0.004), respectively. The CYP2D6 genotype significantly influenced galantamine plasma concentrations. The influence of CYP2D6 polymorphisms on the treatment efficacy and tolerability should be further investigated.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27376364','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27376364"><span>The Sangre <span class="hlt">Por</span> Salud Biobank: Facilitating Genetic Research in an Underrepresented Latino Community.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Shaibi, Gabriel; Singh, Davinder; De Filippis, Eleanna; Hernandez, Valentina; Rosenfeld, Bill; Otu, Essen; Montes de Oca, Gregorio; Levey, Sharon; Radecki Breitkopf, Carmen; Sharp, Richard; Olson, Janet; Cerhan, James; Thibodeau, Stephen; Winkler, Erin; Mandarino, Lawrence</p> <p>2016-01-01</p> <p>The Sangre <span class="hlt">Por</span> Salud (Blood for Health; SPS) Biobank was created for the purpose of expanding precision medicine research to include underrepresented Latino patients. It is the result of a unique collaboration between Mayo Clinic and Mountain Park Health Center, a federally qualified community health center in Phoenix, Arizona. This report describes the rationale, development, implementation, and characteristics of the SPS Biobank. Latino adults (ages 18-85 years) who were active patients within Mountain Park Health Center's internal medicine practice in Phoenix, Ariz., and had no history of diabetes were eligible. Participants provided a personal and family history of chronic disease, completed a sociodemographic, psychosocial, and behavioral questionnaire, underwent a comprehensive cardiometabolic risk assessment (anthropometrics, blood pressure and labs), and provided blood samples for banking. Laboratory results of cardiometabolic testing were returned to the participants and their providers through the electronic health record. During the first 2 years of recruitment into the SPS Biobank, 2,335 patients were approached and 1,432 (61.3%) consented to participate; 1,354 (94.5%) ultimately completed all requisite questionnaires and medical evaluations. The cohort is primarily Spanish-speaking (72.9%), female (73.3%), with a mean age of 41.3 ± 12.5 years. Most participants were born outside of the US (77.9%) and do not have health insurance (77.5%). The prevalence of overweight (35.5%) and obesity (45.0%) was high, as was previously unidentified prediabetes (55.9%), type 2 diabetes (7.4%), prehypertension (46.8%), and hypertension (16.2%). The majority of participants rated their health as good to excellent (72.1%) and, as a whole, described their overall quality of life as high (7.9/10). Collaborative efforts such as the SPS Biobank are critical for ensuring that underrepresented minority populations are included in precision medicine initiatives and biomedical</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5892419','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5892419"><span>The Sangre <span class="hlt">Por</span> Salud Biobank: Facilitating Genetic Research in an Underrepresented Latino Community</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Shaibi, Gabriel; Singh, Davinder; De Filippis, Eleanna; Hernandez, Valentina; Rosenfeld, Bill; Otu, Essen; de Oca, Gregorio Montes; Levey, Sharon; Breitkopf, Carmen Radecki; Sharp, Richard; Olson, Janet; Cerhan, James; Thibodeau, Stephen; Winkler, Erin; Mandarino, Lawrence</p> <p>2018-01-01</p> <p>Background/Aims The Sangre <span class="hlt">Por</span> Salud (Blood for Health; SPS) Biobank was created for the purpose of expanding precision medicine research to include underrepresented Latino patients. It is the result of a unique collaboration between Mayo Clinic and Mountain Park Health Center, a federally qualified community health center in Phoenix, Arizona. This report describes the rationale, development, implementation, and characteristics of the SPS Biobank. Methods Latino adults (ages 18–85 years) who were active patients within Mountain Park Health Center’s internal medicine practice in Phoenix, Ariz., and had no history of diabetes were eligible. Participants provided a personal and family history of chronic disease, completed a sociodemographic, psychosocial, and behavioral questionnaire, underwent a comprehensive cardiometabolic risk assessment (anthropometrics, blood pressure and labs), and provided blood samples for banking. Laboratory results of cardiometabolic testing were returned to the participants and their providers through the electronic health record. Results During the first 2 years of recruitment into the SPS Biobank, 2,335 patients were approached and 1,432 (61.3%) consented to participate; 1,354 (94.5%) ultimately completed all requisite questionnaires and medical evaluations. The cohort is primarily Spanish-speaking (72.9%), female (73.3%), with a mean age of 41.3 ± 12.5 years. Most participants were born outside of the US (77.9%) and do not have health insurance (77.5%). The prevalence of overweight (35.5%) and obesity (45.0%) was high, as was previously unidentified prediabetes (55.9%), type 2 diabetes (7.4%), prehypertension (46.8%), and hypertension (16.2%). The majority of participants rated their health as good to excellent (72.1%) and, as a whole, described their overall quality of life as high (7.9/10). Conclusion Collaborative efforts such as the SPS Biobank are critical for ensuring that underrepresented minority populations are included in</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFM.V23C0494L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFM.V23C0494L"><span>Historical volcanic eruptions in the Canary Islands, tephra composition, and insights into the crystal cargo of basaltic magmas</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Longpre, M. A.; Muller, J.; Beaudry, P.; Andronikides, A.; Felpeto, A.</p> <p>2017-12-01</p> <p>Since the 16th century, at least 13 volcanic eruptions have occurred in the Canary Islands that formed monogenetic cinder cones and lava flow fields: 2 on Lanzarote, 4 on Tenerife, 6 on La Palma, and 1 on the submarine flank of El <span class="hlt">Hierro</span>. Here we present a comprehensive new dataset of tephra composition for all 13 eruptions, comprising major and trace element data for bulk rocks and matrix glasses, as well as vesicularity and crystallinity measurements. In addition, we compile available volcanological and petrological information for specific eruptions, including estimates of lava flow area and volume. All lapilli samples show a vesicularity of 40-50 vol% and a vesicle-free crystallinity (crystals ≥ 250 µm) of 5-15 vol%. Modal mineralogy varies significantly between samples, typically consisting of olivine ± clinopyroxene ± Fe-Ti oxide ± plagioclase ± amphibole in different proportions. All but 2 tephras have basanite-tephrite bulk rock compositions. Lapilli from vents of the AD 1730-1736 Timanfaya eruption, Lanzarote, largely are basaltic, whereas the AD 1798 Chahorra eruption, Tenerife, produced phonotephrite tephra. These results are in agreement with published bulk lava flow data. Unsurprisingly, glass compositions are more evolved than bulk rocks and MgOglass is weakly positively correlated to MgObulk (MgOglass = 0.30*MgObulk + 2.11, R2 = 0.54). Both bulk rocks and glasses show strikingly similar multi-element diagram patterns, with strong enrichment relative to the bulk-silicate Earth and marked positive Nb and Ta and negative Pb anomalies — typical for ocean island basalts. Glass/bulk rock elemental ratios reveal systematic differences between samples that relate to their mineralogy; for example, Lanzarote tephras that lack significant clinopyroxene and Fe-Ti oxide crystals have higher Scglass/Scbulk and Vglass/Vbulk than Tenerife, La Palma and El <span class="hlt">Hierro</span> samples that typically contain these minerals. Among all elements, K and P display the greatest</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015JVGR..308..127R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015JVGR..308..127R"><span>Are volcanic seismic b-values high, and if so when?</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Roberts, Nick S.; Bell, Andrew F.; Main, Ian G.</p> <p>2015-12-01</p> <p>The Gutenberg-Richter exponent b is a measure of the relative proportion of large and small earthquakes. It is commonly used to infer material properties such as heterogeneity, or mechanical properties such as the state of stress from earthquake populations. It is 'well known' that the b-value tends to be high or very high for volcanic earthquake populations relative to b = 1 for those of tectonic earthquakes, and that b varies significantly with time during periods of unrest. We first review the supporting evidence from 34 case studies, and identify weaknesses in this argument due predominantly to small sample size, the narrow bandwidth of magnitude scales available, variability in the methods used to assess the minimum or cutoff magnitude Mc, and to infer b. Informed by this, we use synthetic realisations to quantify the effect of choice of the cutoff magnitude on maximum likelihood estimates of b, and suggest a new work flow for this choice. We present the first quantitative estimate of the error in b introduced by uncertainties in estimating Mc, as a function of the number of events and the b-value itself. This error can significantly exceed the commonly-quoted statistical error in the estimated b-value, especially for the case that the underlying b-value is high. We apply the new methods to data sets from recent periods of unrest in El <span class="hlt">Hierro</span> and Mount Etna. For El <span class="hlt">Hierro</span> we confirm significantly high b-values of 1.5-2.5 prior to the 10 October 2011 eruption. For Mount Etna the b-values are indistinguishable from b = 1 within error, except during the flank eruptions at Mount Etna in 2001-2003, when 1.5 < b < 2.0. For the time period analysed, they are rarely lower than b = 1. Our results confirm that these volcano-tectonic earthquake populations can have systematically high b-values, especially when associated with eruptions. At other times they can be indistinguishable from those of tectonic earthquakes within the total error. The results have significant</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27737397','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27737397"><span>Hypertriglyceridemia: Is there a role for prophylactic apheresis? A case report.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Francisco, Ana Rita; Gonçalves, Inês; Veiga, Fátima; Pedro, Mónica Mendes; Pinto, Fausto J; Brito, Dulce</p> <p>2016-01-01</p> <p>Severe hypertriglyceridemia has been consistently associated with an increased risk of cardiovascular disease and other complications, namely acute pancreatitis. We report a case of a 64 year-old woman with hypertrophic cardiomyopathy and metabolic syndrome with triglyceride level of 3260 mg/dL. Plasma exchange was performed with simultaneous medical treatment to achieve a rapid and effective lowering of triglycerides in order to prevent clinical complications. After three plasmapheresis sessions a marked reduction in triglyceride and total cholesterol levels was observed. Several cases have shown the importance of plasmapheresis in the treatment of acute pancreatitis. We intend to demonstrate the applicability of this technique as primary prophylaxis in the presence of extremely high serum triglyceridemia levels. Resumo A hipertrigliceridemia grave tem sido associada de forma consistente ao aumento do risco cardiovascular e a outras complicações, nomeadamente, pancreatite <span class="hlt">aguda</span>. Descrevemos um caso de uma mulher de 64 anos, com miocardiopatia hipertrófica e síndrome metabólica com valor sérico de triglicerídeos de 3260 mg/dL. Foi efectuada plasmaferese e optimizado o tratamento médico para alcançar uma redução rápida e efectiva dos níveis dos triglicerídeos, prevenindo complicações clínicas. Após três sessões de plasmaferese, verificou-se uma redução marcada dos triglicerídeos e do colesterol total. Existem alguns casos descritos na literatura demonstrado a importância da plasmaferese no tratamento da pancreatite <span class="hlt">aguda</span> em contexto de hipertrigliceridemia grave. Os autores pretendem com este caso demonstrar a aplicabilidade desta técnica em contexto de prevenção primária em doentes com níveis de triglicerídeos extremamente aumentados.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12623647','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12623647"><span>Selenium and mercury concentrations in sweet and dry bottled wines from the Canary Islands, Spain.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Frías, S; Díaz, C; Conde, J E; Pérez Trujillo, J P</p> <p>2003-03-01</p> <p>The concentrations of selenium and mercury were determined by atomic absorption spectrophotometry in sweet and dry bottled wines from the Canary Islands, Spain. The concentrations of mercury ranged from 2.6 to 4.9 microg x l(-1) for sweet wines, and from 1.5 to 2.6 microg x l(-1) for dry wines, differences (p < 0.05) being observed according to the island of production and type of wine, but not with respect to vintage. The concentration of selenium varied between 1.0 and 2.0 microg x l(-1) for sweet wines, and between 0.6 and 1.6 microg x l(-1) for dry wines. Differences were found in the mean concentrations according to the type of wine. Dry wines produced in La Palma presented a higher (p < 0.05) mean content than those observed in the wines of El <span class="hlt">Hierro</span> and Lanzarote.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4570429','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4570429"><span>Use of Low-Cost Acquisition Systems with an Embedded Linux Device for Volcanic Monitoring</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Moure, David; Torres, Pedro; Casas, Benito; Toma, Daniel; Blanco, María José; Del Río, Joaquín; Manuel, Antoni</p> <p>2015-01-01</p> <p>This paper describes the development of a low-cost multiparameter acquisition system for volcanic monitoring that is applicable to gravimetry and geodesy, as well as to the visual monitoring of volcanic activity. The acquisition system was developed using a System on a Chip (SoC) Broadcom BCM2835 Linux operating system (based on DebianTM) that allows for the construction of a complete monitoring system offering multiple possibilities for storage, data-processing, configuration, and the real-time monitoring of volcanic activity. This multiparametric acquisition system was developed with a software environment, as well as with different hardware modules designed for each parameter to be monitored. The device presented here has been used and validated under different scenarios for monitoring ocean tides, ground deformation, and gravity, as well as for monitoring with images the island of Tenerife and ground deformation on the island of El <span class="hlt">Hierro</span>. PMID:26295394</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26295394','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26295394"><span>Use of Low-Cost Acquisition Systems with an Embedded Linux Device for Volcanic Monitoring.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Moure, David; Torres, Pedro; Casas, Benito; Toma, Daniel; Blanco, María José; Del Río, Joaquín; Manuel, Antoni</p> <p>2015-08-19</p> <p>This paper describes the development of a low-cost multiparameter acquisition system for volcanic monitoring that is applicable to gravimetry and geodesy, as well as to the visual monitoring of volcanic activity. The acquisition system was developed using a System on a Chip (SoC) Broadcom BCM2835 Linux operating system (based on DebianTM) that allows for the construction of a complete monitoring system offering multiple possibilities for storage, data-processing, configuration, and the real-time monitoring of volcanic activity. This multiparametric acquisition system was developed with a software environment, as well as with different hardware modules designed for each parameter to be monitored. The device presented here has been used and validated under different scenarios for monitoring ocean tides, ground deformation, and gravity, as well as for monitoring with images the island of Tenerife and ground deformation on the island of El <span class="hlt">Hierro</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2010RELEA...9....7D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2010RELEA...9....7D"><span>Astronomy in the Classroom: Why? (Spanish Title: Astronomía en la Clase: ¿<span class="hlt">Por</span> Qué?) Astronomia na Sala de Aula: <span class="hlt">Por</span> Quê?</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Daros Gama, Leandro; Bagdonas Henrique, Alexandre</p> <p>2010-07-01</p> <p>There are many discussions about the relevance of the topics covered in classes. One subject in particular is the focus of this essay: astronomy. In what sense and to what extent it would be worth to teach it in science or other kind of classes? In this paper we discuss some aspects of the advantages of dealing with this area of knowledge in schools, taking into account the epistemological and axiological dimensions of astronomy, in light of the vision of science as an intelligent dialogue with the world (Bachelard), in addition to the "problematization" knowledge of Paulo Freire. We propose that in fact the Astronomy does not need to be seen as just a new set of contents to be taught, but appears as a set of motivational contents for historical-philosophical discussions, and permit the discussion of concepts of other disciplines. Numerosas discusiones se están llevando a cabo acerca de la pertinencia de los temas tradicionalmente tratados en las clases. Uno de los temas, en particular, es el foco de este ensayo: la astronomía. ¿En qué sentido y en qué medida sería conveniente tratarla en clase, ya sea en clases de ciencias naturales, específicamente en las de astronomía o asignaturas afines? Elaboramos en este artículo algunos aspectos de las ventajas de tratar esta área del conocimiento en las escuelas, teniendo en cuenta las dimensiones epistemológica y axiológica de la astronomía, a la luz de la visión de la ciencia como un diálogo inteligente con el mundo (Bachelard), además de la propuesta del conocimiento "problematizador" de Paulo Freire. Proponemos que en realidad la astronomía no tiene <span class="hlt">por</span> qué ser vista sólo como un nuevo conjunto de contenidos que se enseñan, sino que aparece como un conjunto de temas de motivación para el debate histórico-filosófico y para permitir la discusión de los conceptos típicos de otras disciplinas. Muitas discussões vêm acontecendo sobre a relevância dos temas abordados em sala de aula. Um tema, em</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5672659','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5672659"><span>Trayectoria de los tornillos pediculares lumbares y sacros: Comparación entre el abordaje <span class="hlt">por</span> linea media versus el abordaje posterolateral tipo wiltse</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Gagliardi, Martín; Guiroy, Alfredo; Molina, Federico Fernández; Fasano, Francisco; Ciancio, Alejandro Morales; Mezzadri, Juan José; Jalón, Pablo</p> <p>2017-01-01</p> <p>Resumen Objetivos: El objetivo de este estudio fue comparar, en fusiones lumbosacras cortas, el ángulo de convergencia de los tornillos pediculares entre el abordaje posterolateral tipo Wiltse y el abordaje mediano convencional. Método: Se revisaron en forma retrospectiva los controles en tomografía axial computada (TAC) de 76 tornillos pediculares lumbares y sacros colocados <span class="hlt">por</span> vía posterior, mediante un abordaje mediano convencional (n: 38) o <span class="hlt">por</span> vía posterolateral transmuscular tipo Wiltse (n: 38). Se incluyeron fusiones lumbosacras cortas desde L3 a S1, en pacientes adultos, con patología degenerativa. Se excluyeron los tornillos con una brecha ósea >4 mm en cualquier dirección, los casos con instrumentaciones pediculares previas y aquellos con curvas en el plano coronal mayores de 20°. Resultados: Considerando la totalidad de los implantes, el ángulo de convergencia fue de 23,3° (+/- 15,82). La angulación promedio, en el grupo AW, fue de 29,3° (+/- 9,72). En el grupo AC, el grado de convergencia de los implantes fue de 17,2° (+/- 10,58). Esta diferencia fue estadísticamente significativa (P < 0,0001). Para el grupo AW, el grado de convergencia según nivel fue el siguiente: L3: 31,2° (+/- 1,9); L4: 31,4° (+/- 2,76); L5: 31,1° (+/- 5,62); S1: 24,2° (+/- 12,16). El promedio del ángulo del tornillo según nivel para el grupo AC fue: L3: 16° (+/- 7,16); L4: 20,3° (+/- 6,9) L5: 15,9° (+/- 13,38); S1: 15,2° (+/- 14,32). Los implantes del grupo AW tuvieron ángulos significativamente más convergentes que el grupo AC en todos los segmentos explorados. Conclusión: En las fusiones lumbosacras cortas, la utilización del abordaje tipo Wiltse permitió la colocación de tornillos pediculares con más convergencia que en el abordaje mediano convencional. La relevancia clínica de este hecho es desconocida y se requerirían trabajos prospectivos randomizados para determinar la misma. PMID:29142777</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014GGG....15.3322H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014GGG....15.3322H"><span>Long-term (17 Ma) turbidite record of the timing and frequency of large flank collapses of the Canary Islands</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Hunt, J. E.; Talling, P. J.; Clare, M. A.; Jarvis, I.; Wynn, R. B.</p> <p>2014-08-01</p> <p>Volcaniclastic turbidites on the Madeira Abyssal Plain provide a record of large-volume volcanic island flank collapses from the Canary Islands. This long-term record spans 17 Ma, and comprises 125 volcaniclastic beds. Determining the timing, provenance and volumes of these turbidites provides key information about the occurrence of mass wasting from the Canary Islands, especially the western islands of Tenerife, La Palma and El <span class="hlt">Hierro</span>. These turbidite records demonstrate that landslides often coincide with protracted periods of volcanic edifice growth, suggesting that loading of the volcanic edifices may be a key preconditioning factor for landslide triggers. Furthermore, the last large-volume failures from Tenerife coincide with explosive volcanism at the end of eruptive cycles. Many large-volume Canary Island landslides also occurred during periods of warmer and wetter climates associated with sea-level rise and subsequent highstand. However, these turbidites are not serially dependent and any association with climate or sea level change is not statistically significant.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JVGR..356..127C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JVGR..356..127C"><span>Serreta 1998-2001 submarine volcanic eruption, offshore Terceira (Azores): Characterization of the vent and inferences about the eruptive dynamics</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Casas, David; Pimentel, Adriano; Pacheco, José; Martorelli, Eleonora; Sposato, Andrea; Ercilla, Gemma; Alonso, Belen; Chiocci, Francesco</p> <p>2018-05-01</p> <p>High-resolution bathymetric data and seafloor sampling were used to characterize the most recent volcanic eruption in the Azores region, the 1998-2001 Serreta submarine eruption. The vent of the eruption is proposed to be an asymmetric topographic high, composed of two coalescing volcanic cones, underlying the location where lava balloons had been observed at the sea surface during the eruption. The volcanic products related to the 1998-2001 eruption are constrained to an area of 0.5 km2 around the proposed vent position. A submarine Strombolian-style eruption producing basaltic lava balloons, ash and coarse scoriaceous materials with limited lateral dispersion led to the buildup of the cones. The 1998-2001 Serreta eruption shares many similarities with other intermediate-depth lava balloon-forming eruptions (e.g., the 1891 eruption offshore Pantelleria and the 2011-2012 eruption south of El <span class="hlt">Hierro</span>), revealing the particular conditions needed for the production of this unusual and scarcely documented volcanic product.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25238851','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25238851"><span>[Nutrition and child development I; nutritional status of school children in a peripheral district of Madrid (Rev Clin Esp 1944; XII:87-94)].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Grande Covián, F; Rof Carballo, J; Jiménez García, F; Morata Cernuda, A</p> <p>2014-09-01</p> <p>El estudio clínico del estado nutritivo de un grupo de niños en edad escolar, habitantes de un suburbio madrileño revela la existencia, relativamente rara, de signos carenciales específicos, que contrasta vivamente con el considerable retraso que se observa en su desarrollo somático. Los hechos parecen demostrar que el problema nutritivo de estos niños es sobre todo un problema cuantitativo. El retraso de la evolución está en relación con la insuficiencia global de la dieta y con el déficit de calcio que es probablemente el elemento individual con mayor grado de carencia en las dietas. La anemia que presenta el 98% de los niños no parece deberse únicamente a una deficiencia de <span class="hlt">hierro</span> porque la dieta parece tener una cantidad adecuada; probablemente esté más en relación con el exiguo contenido de proteínas animales de la ración.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16351960','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16351960"><span>Relationship between diet and helminths in Gallotia caesaris (Sauria: Lacertidae).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Martin, J E; Llorente, G A; Roca, V; Carretero, M A; Montori, A; Santos, X; Romeu, R</p> <p>2005-01-01</p> <p>Diet and helminth fauna were analysed in Gallotia caesaris, a small lacertid lizard endemic to El <span class="hlt">Hierro</span> (Canary Islands, Spain) in order to study the evolutionary and functional relationships between the two traits. This species is omnivorous but consumed a high proportion (82.13%) of plant matter including not only seeds but also leaves and other vegetative parts. Helminth fauna included many helminth species typical of herbivorous reptiles. Both herbivory and helminth presence were higher than expected for a lizard of its size. Comparison with other lacertids suggests that both traits result from an adaptation to insular conditions but that some "evolutionary time" to develop them is needed. Canarian Gallotia lizards, a separate lineage evolving for a long time in insularity, constitutes the most advanced lacertid group in this way. Nevertheless, results for G. caesaris indicate that helminth fauna also changes seasonally tracking variation in diet (and herbivory) throughout the year, which suggests a dynamic interaction between diet and helminth parasites.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3071654','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3071654"><span>Estimaciones de Prevalencia del VIH <span class="hlt">por</span> Género y Grupo de Riesgo en Tijuana, México: 2006</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Iñiguez-Stevens, Esmeralda; Brouwer, Kimberly C.; Hogg, Robert S.; Patterson, Thomas L.; Lozada, Remedios; Magis-Rodriguez, Carlos; Elder, John P.; Viani, Rolando M.; Strathdee, Steffanie A.</p> <p>2010-01-01</p> <p>OBJETIVO Estimar la prevalencia del VIH en adultos de 15-49 años de edad en Tijuana, México - en la población general y en subgrupos de riesgo en el 2006. METODOS Se obtuvieron datos demográficos del censo Mexicano del 2005, y la prevalencia del VIH se obtuvo de la literatura. Se construyó un modelo de prevalencia del VIH para la población general y de acuerdo al género. El análisis de sensibilidad consistió en estimar errores estándar del promedio-ponderado de la prevalencia del VIH y tomar derivados parciales con respecto a cada parámetro. RESULTADOS La prevalencia del VIH es 0.54%(N = 4,347) (Rango: 0.22%–0.86%, (N = 1,750–6,944)). Esto sugiere que 0.85%(Rango: 0.39%–1.31%) de los hombres y 0.22%(Rango: 0.04%–0.40%) de las mujeres podrían ser VIH-positivos. Los hombres que tienen sexo con hombres (HSH), las trabajadoras sexuales usuarias de drogas inyectables (MTS-UDI), MTS-noUDI, mujeres UDI, y los hombres UDI contribuyeron las proporciones más elevadas de personas infectadas <span class="hlt">por</span> el VIH. CONCLUSIONES El número de adultos VIH-positivos entre subgrupos de riesgo en la población de Tijuana es considerable, marcando la necesidad de enforcar las intervenciones de prevención en sus necesidades específicas. El presente modelo estima que hasta 1 en cada 116 adultos podrían ser VIH-positivos. PMID:19685824</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015EGUGA..17.5101R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015EGUGA..17.5101R"><span>High volcanic seismic b-values: Real or artefacts?</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Roberts, Nick; Bell, Andrew; Main, Ian G.</p> <p>2015-04-01</p> <p>The b-value of the Gutenberg-Richter distribution quantifies the relative proportion of large to small magnitude earthquakes in a catalogue, in turn related to the population of fault rupture areas and the average slip or stress drop. Accordingly the b-value is an important parameter to consider when evaluating seismic catalogues as it has the potential to provide insight into the temporal or spatial evolution of the system, such as fracture development or changes in the local stress regime. The b-value for tectonic seismicity is commonly found to be close to 1, whereas much higher b-values are frequently reported for volcanic and induced seismicity. Understanding these differences is important for understanding the processes controlling earthquake occurrence in different settings. However, it is possible that anomalously high b-values could arise from small sample sizes, under-estimated completeness magnitudes, or other poorly applied methodologies. Therefore, it is important to establish a rigorous workflow for analyzing these datasets. Here we examine the frequency-magnitude distributions of volcanic earthquake catalogues in order to determine the significance of apparently high b-values. We first derive a workflow for computing the completeness magnitude of a seismic catalogue, using synthetic catalogues of varying shape, size, and known b-value. We find the best approach involves a combination of three methods: 'Maximum Curvature', 'b-value stability', and the 'Goodness-of-Fit test'. To calculate a reliable b-value with an error ≤0.25, the maximum curvature method is preferred for a 'sharp-peaked' discrete distribution. For a catalogue with a broader peak the b-value stability method is the most reliable with the Goodness-of-Fit test being an acceptable backup if the b-value stability method fails. We apply this workflow to earthquake catalogues from El <span class="hlt">Hierro</span> (2011-2013) and Mt Etna (1999-2013) volcanoes. In general, we find the b-value to be equal to or</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/15454356','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/15454356"><span>Results of Mujeres Felices <span class="hlt">por</span> ser Saludables: a dietary/breast health randomized clinical trial for Latino women.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Fitzgibbon, Marian L; Gapstur, Susan M; Knight, Sara J</p> <p>2004-10-01</p> <p>Data are limited on the efficacy of health-focused interventions for young, low-acculturated Latino women. Because breast cancer is the most commonly diagnosed cancer and the most common cause of cancer mortality in this population, combined interventions that address both early detection and dietary patterns could help reduce both morbidity and mortality associated with breast cancer in this underserved population. Mujeres Felices <span class="hlt">por</span> ser Saludables was randomized intervention study designed to assess the efficacy of an 8-month combined dietary and breast health intervention to reduce fat and increase fiber intake as well as to increase the frequency and proficiency of breast self-examination (BSE) and reduce anxiety related to BSE among Latinas. Blocked randomization in blocks of 6 was used to randomize 256 20- to 40-year-old Latinas to the intervention (n = 127) or control group (n = 129). The intervention group attended an 8-month multicomponent education program designed specifically for low-acculturated Latinas. The control group received mailed health education material on a schedule comparable to the intervention. A total of 195 women (76.2%) completed both the baseline and 8-month follow-up interviews. The intervention and control groups were similar on baseline sociodemographic characteristics. At the 8-month follow up, the intervention group reported lower dietary fat (P < .001) and higher fiber intake (p = .06); a higher proportion reported practicing BSE at the recommended interval (p < .001) and showed improved BSE proficiency (p < .001) compared to the control group. BSE-related anxiety was low for both groups at baseline, and no difference in reduction was observed. This project provides a successful model for achieving dietary change and improving breast health behavior in young, low-acculturated Latinas.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2002BAAA...45...38C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2002BAAA...45...38C"><span>Bifurcación de las soluciones de vientos impulsados <span class="hlt">por</span> radiación en estrellas Be: formación de líneas</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Curé, M.; Rial, D.; Cidale, L.; Venero, R.</p> <p></p> <p>Se ha estudiado la topología de la ecuación hidrodinámica no-lineal que describe el perfil de velocidades de vientos impulsados <span class="hlt">por</span> radiación en estrellas tempranas. Al aplicar este modelo a estrellas Be se encuentra que existen dos tipos De soluciones: la estándar, que describe el viento polar, y una nueva, que describe un viento más denso y lento y que explicaría el disco que se encuentra alrededor de estos objetos. Existe una región de transición en donde ambas soluciones coexisten (bifurcación}). Ambas soluciones satisfacen en esta región las mismas condiciones de borde. Para estas dos soluciones se han obtenido los perfiles de líneas de hidrógeno del visible y del IR, resolviendo el transporte de radiación en el ``comoving frame". Para la solución estándar, se obtienen perfiles con componentes en emisión, mientras que para la nueva solución se obtienen perfiles en absorción. Se comparan cualitativamente los resultados con las observaciones.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li class="active"><span>13</span></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_13 --> <div id="page_14" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li class="active"><span>14</span></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="261"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28032856','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28032856"><span>Are probiotics effective to prevent traveler’s diarrhea?</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Pinos, Yazmín; Castro-Gutiérrez, Victoria; Rada, Gabriel</p> <p>2016-12-23</p> <p>La diarrea <span class="hlt">aguda</span> es la enfermedad más común que afecta a los viajeros, principalmente aquellos que se dirigen a regiones de alto riesgo. El uso de probióticos podría prevenir su aparición, sin embargo, los datos que apoyan su uso no son consistentes y no se recomiendan en las guías clínicas actuales. Utilizando la base de datos Epistemonikos, la cual es mantenida mediante búsquedas en múltiples bases de datos, identificamos cuatro revisiones sistemáticas que en conjunto incluyen siete estudios aleatorizados pertinentes a esta pregunta. Realizamos un metanálisis y tablas de resumen de los resultados utilizando el método GRADE. Concluimos que los probióticos podrían prevenir la diarrea del viajero, pero la certeza de la evidencia es baja.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20307675','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20307675"><span>Divergence times and colonization of the Canary Islands by Gallotia lizards.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cox, Siobhan C; Carranza, Salvador; Brown, Richard P</p> <p>2010-08-01</p> <p> show that G. galloti is likely to have colonized La Palma more than 0.5 Ma after emergence of the island 1.77 mya, while G. caesaris from the same clade may have colonized El <span class="hlt">Hierro</span> very soon after it emerged 1.12 mya. There are tentative indications that the large-bodied endangered G. simonyi colonized El <span class="hlt">Hierro</span> around the same time or even later than the smaller-bodied G. caesaris. This study demonstrates the effectiveness of Bayesian dating of a phylogeny in helping reconstruct the historical pattern of dispersal across an oceanic archipelago. Copyright 2010 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27579543','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27579543"><span>Fondaparinux versus Enoxaparin - Which is the Best Anticoagulant for Acute Coronary Syndrome? - Brazilian Registry Data.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Soeiro, Alexandre de Matos; Silva, Pedro Gabriel Melo de Barros E; Roque, Eduardo Alberto de Castro; Bossa, Aline Siqueira; César, Maria Cristina; Simões, Sheila Aparecida; Okada, Mariana Yumi; Leal, Tatiana de Carvalho Andreucci Torres; Pedroti, Fátima Cristina Monteiro; Oliveira, Múcio Tavares de</p> <p>2016-09-01</p> <p>Recent studies have shown fondaparinux's superiority over enoxaparin in patients with non-ST elevation acute coronary syndrome (ACS), especially in relation to bleeding reduction. The description of this finding in a Brazilian registry has not yet been documented. To compare fondaparinux versus enoxaparin in in-hospital prognosis of non-ST elevation ACS. Multicenter retrospective observational study. A total of 2,282 patients were included (335 in the fondaparinux group, and 1,947 in the enoxaparin group) between May 2010 and May 2015. Demographic, medication intake and chosen coronary treatment data were obtained. Primary outcome was mortality from all causes. Secondary outcome was combined events (cardiogenic shock, reinfarction, death, stroke and bleeding). Comparison between the groups were done through Chi-Square test and T test. Multivariate analysis was done through logistic regression, with significance values defined as p < 0.05. With regards to treatment, we observed the performance of a percutaneous coronary intervention in 40.2% in the fondaparinux group, and in 35.1% in the enoxaparin group (p = 0.13). In the multivariate analysis, we observed significant differences between fondaparinux and enoxaparin groups in relation to combined events (13.8% vs. 22%. OR = 2.93, p = 0.007) and bleeding (2.3% vs. 5.2%, OR = 4.55, p = 0.037), respectively. Similarly to recently published data in international literature, fondaparinux proved superior to enoxaparin for the Brazilian population, with significant reduction of combined events and bleeding. Estudos recentes têm apresentado superioridade do fondaparinux em relação à enoxaparina em pacientes com síndrome coronariana <span class="hlt">aguda</span> (SCA) sem supradesnivelamento de ST, principalmente relacionada à redução de sangramentos. A descrição desse achado em registro brasileiro ainda não foi documentada. Comparar fondaparinux versus enoxaparina no prognóstico intrahospitalar em SCA sem supradesnivelamento de ST</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29874708','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29874708"><span>Contaminación <span class="hlt">por</span> mercurio de leche materna de madres lactantes de municipios de Antioquia con explotación minera de oro.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Molina, Carlos Federico; Arango, Catalina María; Sepúlveda, Hernán</p> <p>2018-05-01</p> <p>Introducción. La leche materna es esencial para el desarrollo del ser humano, pero puede contener sustancias tóxicas provenientes de la contaminación ambiental, especialmente en las áreas mineras.Objetivo. Determinar la prevalencia de la contaminación con mercurio de la leche materna de mujeres lactantes residentes en los municipios con explotación minera de oro.Materiales y métodos. Se hizo un estudio transversal de 150 madres lactantes de cuatro municipios mineros de Antioquia (El Bagre, Segovia, Remedios y Zaragoza), a quienes se les hizo una encuesta sobre factores sociodemográficos, ocupacionales y ambientales relacionados con el mercurio, y se les tomaron muestras de leche materna, de orina y de cabello. Se calculó el promedio de la concentración de mercurio y las prevalencias municipales de contaminación.Resultados. El promedio de la concentración de mercurio en la leche materna fue de 2,5 (± desviación estándar 9,2) μg/L. La prevalencia de muestras de leche materna con niveles altos de mercurio fue de 11,7 %.Conclusión. En este estudio se evidencia un grave problema en las regiones mineras auríferas de Antioquia <span class="hlt">por</span> el efecto de la contaminación con mercurio en sectores de la población más vulnerable.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4176920','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4176920"><span>Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección <span class="hlt">por</span> Helicobacter pylori1</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Bravo, Luis Eduardo; Bravo, Juan Carlos; Realpe, José Luis; Zarama, Guillermo; Piazuelo, MarÍa Blanca; Correa, Pelayo</p> <p>2014-01-01</p> <p>RESUMEN Introducción El mapeo de las diferentes regiones del estómago y el número de fragmentos de mucosa gástrica disponibles para evaluación histopatológica son fuentes importantes de variación en el momento de clasificar y hacer la gradación de la gastritis crónica. Objetivos Estimar la sensibilidad del número de fragmentos de mucosa gástrica necesarios para establecer los diagnósticos de gastritis atrófica con metaplasia intestinal (MI), displasia y estado de infección <span class="hlt">por</span> Helicobacter pylori. Además evaluar la variabilidad intra-observador en la clasificación de estas lesiones precursoras del cáncer gástrico. Materiales y métodos En una cohorte de 6 años de seguimiento se evaluaron 1,958 procedimientos de endoscopia realizados <span class="hlt">por</span> dos gastroenterólogos. En cada procedimiento y de cada participante se obtuvieron 5 biopsias de mucosa gástrica que representaban antro, incisura angularis y cuerpo. Un único patólogo hizo la interpretación histológica de las 5 biopsias y proporcionó un diagnóstico definitivo global que se utilizó como patrón de referencia. Cada fragmento de mucosa gástrica examinado condujo a un diagnóstico individual para cada biopsia que se comparó con el patrón de referencia. La variabilidad intra-observador se evaluó en 127 personas que corresponden a una muestra aleatoria de 20% del total de endoscopias hechas a los 72 meses de seguimiento. Resultados La sensibilidad del diagnóstico de MI y displasia gástrica aumentó de manera significativa con el número de fragmentos de mucosa gástrica evaluados El sitio anatómico de mayor sensibilidad para el diagnóstico de MI y displasia fue la incisura angularis. Para descubrir H. pylori se logró alta sensibilidad con el estudio de un solo fragmento de mucosa gástrica (95.9%) y fue independiente del sitio de obtención de la biopsia. El acuerdo intra-observador para el diagnóstico de gastritis crónica fue 86.1% con valor kappa de 0.79 IC 95% (0.76-0.85). Las</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27513487','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27513487"><span>[Not Available].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Corella Aznar, Elena Guadalupe; Ayerza Casas, Ariadna; Samper Villagrasa, Pilar; Rodríguez Vigil, Carmen; Jiménez Montañés, Lorenzo; Calvo Escribano, Carlota; Labarta Aizpun, José Ignacio</p> <p>2016-06-30</p> <p>Introducción: los supervivientes de leucemia <span class="hlt">aguda</span> (LA) infantil presentan un riesgo incrementado de alteraciones metabólicas y cardiovasculares que aumentan su morbimortalidad a largo plazo.Objetivo: estimar la prevalencia de obesidad, resistencia a la insulina, dislipemia e hipertensión arterial como factores de riesgo cardiometabólico (FRCM) en un grupo de supervivientes de LA infantil, y analizar las posibles causas asociadas a su desarrollo.Material y métodos: estudio observacional retrospectivo en 47 supervivientes de LA tratados en un periodo de 4 años, que recibieron seguimiento durante 10 años.Resultados: el 40% de los participantes presentaron al menos un FRCM durante el seguimiento, siendo la dislipemia (aumento LDL) el más frecuente (38,3%), seguido de obesidad/sobrepeso (31,9%) y HTA sistólica (23,4%). El sexo femenino se estableció como factor de riesgo parael desarrollo de todos ellos (RR 1,6; RR 3,16; RR 1,69; p < 0,05). Ningún superviviente desarrolló diabetes mellitus, pero sí resistencia a la insulina el 19,4%. Los pacientes con leucemias de peor pronóstico presentaron mayor riesgo de desarrollar obesidad, resistencia a la insulina y aumento de LDL (RR 3,56; RR 4,08; RR 2,53; p < 0,05). Los pacientes tratados con trasplante de progenitores hematopoyéticos presentaron mayor riesgo de obesidad, aumento de LDL e HTA sistólica (RR 2,86; RR 2,39; RR 3,12; p<0,05). La radioterapia se asoció de igual modo con un incremento de resistencia a la insulina e hipertensión arterial sistólica (RR 2,47; RR 2,53; p < 0,05).Conclusiones: existe un aumento en la prevalencia de obesidad/sobrepeso, dislipemia, resistencia a la insulina y alteración de la tensión arterial sistólica en supervivientes de leucemia <span class="hlt">aguda</span> infantil a lo largo del tiempo, especialmente en aquellos con enfermedades y tratamientos más agresivos.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28614421','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28614421"><span>Zero Calcium Score as a Filter for Further Testing in Patients Admitted to the Coronary Care Unit with Chest Pain.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Correia, Luis Cláudio Lemos; Esteves, Fábio P; Carvalhal, Manuela; Souza, Thiago Menezes Barbosa de; Sá, Nicole de; Correia, Vitor Calixto de Almeida; Alexandre, Felipe Kalil Beirão; Lopes, Fernanda; Ferreira, Felipe; Noya-Rabelo, Márcia</p> <p>2017-06-12</p> <p>), na qual a probabilidade pré-teste de DAC é maior do que em outras populações. Pacientes foram submetidos a tomografia computadorizada para quantificar o escore de cálcio, DAC obstrutiva foi definida <span class="hlt">por</span> uma estenose mínima de 70% na cineangiocoronariografia invasiva. Um escore clínico para estimar a probabilidade pré-teste de DAC obstrutiva foi criado em amostra de 370 pacientes, usado para definir subgrupos na definição de valores preditivos negativos do escore zero. Em 146 pacientes estudados, a prevalência de DAC foi 41% e o escore de cálcio zero foi demonstrado em 35% deles. A sensibilidade e a especificidade para escore de cálcio zero resultaram numa razão de verossimilhança negativa de 0,16. Após ajuste com um escore clínico com a regressão logística para a probabilidade pré-teste, o escore de cálcio zero foi preditor independente associado a baixa probabilidade de DAC (OR = 0,12, IC95% = 0,04-0,36), aumentando a área abaixo da curva ROC do modelo clínico de 0,76 para 0,82 (p = 0,006). Considerando a probabilidade de DAC < 10% como ponto de corte para alta precoce, o escore de cálcio aumentou a proporção de pacientes para alta precoce de 8,2% para 25% (NRI = 0,20; p = 0,0018). O escore de cálcio zero apresentou valor preditivo negativo de 90%. Em pacientes com probabilidade pré-teste < 50%, o valor preditivo negativo foi 95% (IC95% = 83%-99%). O escore de cálcio zero reduz substancialmente a probabilidade pré-teste de DAC obstrutiva em pacientes internados em UCI com dor torácica <span class="hlt">aguda</span>. (Arq Bras Cardiol. 2017; [online].ahead print, PP.0-0).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27982375','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27982375"><span>Sociodemographic profile of medicines users in Brazil: results from the 2014 PNAUM survey.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bertoldi, Andréa Dâmaso; Pizzol, Tatiane da Silva Dal; Ramos, Luiz Roberto; Mengue, Sotero Serrate; Luiza, Vera Lucia; Tavares, Noemia Urruth Leão; Farias, Mareni Rocha; Oliveira, Maria Auxiliadora; Arrais, Paulo Sergio Dourado</p> <p>2016-12-01</p> <p>, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM), pesquisa nacional de base populacional, realizada entre setembro de 2013 e fevereiro de 2014 em residências de municípios urbanos. Avaliou-se o uso de todos os medicamentos (global), uso de medicamentos para doenças crônicas e uso de medicamentos para doenças <span class="hlt">agudas</span>. As variáveis independentes utilizadas foram sexo, idade, classificação econômica e região do País. Foram calculados prevalências e intervalos de confiança de 95% (IC95%) e aplicado teste Qui-quadrado de Pearson para avaliação das diferenças entre os grupos, considerando o nível de significância de 5%. A prevalência global de uso de medicamentos foi de 50,7% (IC95% 49,3-52,2), sendo 39,3% (IC95% 37,5-41,1) no sexo masculino e 61,0% (IC95% 59,3-62,6) no sexo feminino. Observou-se aumento nas prevalências de uso com a idade (exceto de zero a quatro anos). As menores prevalências de uso ocorreram no grupo mais pobre e na região Norte do País. A prevalência de uso de medicamentos para doenças crônicas foi de 24,3% (IC95% 23,3-25,4) e para doenças <span class="hlt">agudas</span> foi de 33,7% (IC95% 32,1-35,4). Existe grande variabilidade nas prevalências globais de uso de medicamentos <span class="hlt">por</span> regiões brasileiras. As regiões consideradas mais pobres (Norte, Nordeste e Centro-Oeste) apresentam menores prevalências de uso de medicamentos para doenças crônicas, o que indica a necessidade de minimizar as desigualdades no acesso aos medicamentos dentro do País.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25352461','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25352461"><span>Focused Cardiac Ultrasound Using a Pocket-Size Device in the Emergency Room.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mancuso, Frederico José Neves; Siqueira, Vicente Nicoliello; Moisés, Valdir Ambrósio; Gois, Aécio Flavio Teixeira; Paola, Angelo Amato Vincenzo de; Carvalho, Antonio Carlos Camargo; Campos, Orlando</p> <p>2014-10-28</p> <p>Background: Cardiovascular urgencies are frequent reasons for seeking medical care. Prompt and accurate medical diagnosis is critical to reduce the morbidity and mortality of these conditions. Objective: To evaluate the use of a pocket-size echocardiography in addition to clinical history and physical exam in a tertiary medical emergency care. Methods: One hundred adult patients without known cardiac or lung diseases who sought emergency care with cardiac complaints were included. Patients with ischemic changes in the electrocardiography or fever were excluded. A focused echocardiography with GE Vscan equipment was performed after the initial evaluation in the emergency room. Cardiac chambers dimensions, left and right ventricular systolic function, intracardiac flows with color, pericardium, and aorta were evaluated. Results: The mean age was 61 ± 17 years old. The patient complaint was chest pain in 51 patients, dyspnea in 32 patients, arrhythmia to evaluate the left ventricular function in ten patients, hypotension/dizziness in five patients and edema in one patient. In 28 patients, the focused echocardiography allowed to confirm the initial diagnosis: 19 patients with heart failure, five with acute coronary syndrome, two with pulmonary embolism and two patients with cardiac tamponade. In 17 patients, the echocardiography changed the diagnosis: ten with suspicious of heart failure, two with pulmonary embolism suspicious, two with hypotension without cause, one suspicious of acute coronary syndrome, one of cardiac tamponade and one of aortic dissection. Conclusion: The focused echocardiography with pocket-size equipment in the emergency care may allow a prompt diagnosis and, consequently, an earlier initiation of the therapy.Fundamento: As urgências cardiovasculares são causas importantes de procura <span class="hlt">por</span> atendimento médico, sendo fundamentais a rapidez e a precisão no diagnóstico para diminuir sua morbimortalidade. Objetivo: Avaliar o uso da ecocardiografia</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015PApGe.172.3189F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015PApGe.172.3189F"><span>An Overview of Geodetic Volcano Research in the Canary Islands</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Fernández, José; González, Pablo J.; Camacho, Antonio G.; Prieto, Juan F.; Brú, Guadalupe</p> <p>2015-11-01</p> <p>The Canary Islands are mostly characterized by diffuse and scattered volcanism affecting a large area, with only one active stratovolcano, the Teide-Pico Viejo complex (Tenerife). More than 2 million people live and work in the 7,447 km2 of the archipelago, resulting in an average population density three times greater than the rest of Spain. This fact, together with the growth of exposure during the past 40 years, increases volcanic risk with respect previous eruptions, as witnessed during the recent 2011-2012 El <span class="hlt">Hierro</span> submarine eruption. Therefore, in addition to purely scientific reasons there are economic and population-security reasons for developing and maintaining an efficient volcano monitoring system. In this scenario geodetic monitoring represents an important part of the monitoring system. We describe volcano geodetic monitoring research carried out in the Canary Islands and the results obtained. We consider for each epoch the two main existing constraints: the level of volcanic activity in the archipelago, and the limitations of the techniques available at the time. Theoretical and observational aspects are considered, as well as the implications for operational volcano surveillance. Current challenges of and future perspectives in geodetic volcano monitoring in the Canaries are also presented.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28812643','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28812643"><span>A submarine volcanic eruption leads to a novel microbial habitat.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Danovaro, Roberto; Canals, Miquel; Tangherlini, Michael; Dell'Anno, Antonio; Gambi, Cristina; Lastras, Galderic; Amblas, David; Sanchez-Vidal, Anna; Frigola, Jaime; Calafat, Antoni M; Pedrosa-Pàmies, Rut; Rivera, Jesus; Rayo, Xavier; Corinaldesi, Cinzia</p> <p>2017-04-24</p> <p>Submarine volcanic eruptions are major catastrophic events that allow investigation of the colonization mechanisms of newly formed seabed. We explored the seafloor after the eruption of the Tagoro submarine volcano off El <span class="hlt">Hierro</span> Island, Canary Archipelago. Near the summit of the volcanic cone, at about 130 m depth, we found massive mats of long, white filaments that we named Venus's hair. Microscopic and molecular analyses revealed that these filaments are made of bacterial trichomes enveloped within a sheath and colonized by epibiotic bacteria. Metagenomic analyses of the filaments identified a new genus and species of the order Thiotrichales, Thiolava veneris. Venus's hair shows an unprecedented array of metabolic pathways, spanning from the exploitation of organic and inorganic carbon released by volcanic degassing to the uptake of sulfur and nitrogen compounds. This unique metabolic plasticity provides key competitive advantages for the colonization of the new habitat created by the submarine eruption. A specialized and highly diverse food web thrives on the complex three-dimensional habitat formed by these microorganisms, providing evidence that Venus's hair can drive the restart of biological systems after submarine volcanic eruptions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24451461','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24451461"><span>Embedded ARM system for volcano monitoring in remote areas: application to the active volcano on Deception Island (Antarctica).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Peci, Luis Miguel; Berrocoso, Manuel; Fernández-Ros, Alberto; García, Alicia; Marrero, José Manuel; Ortiz, Ramón</p> <p>2014-01-02</p> <p>This paper describes the development of a multi-parameter system for monitoring volcanic activity. The system permits the remote access and the connection of several modules in a network. An embedded ARM™ processor has been used, allowing a great flexibility in hardware configuration. The use of a complete Linux solution (Debian™) as Operating System permits a quick, easy application development to control sensors and communications. This provides all the capabilities required and great stability with relatively low energy consumption. The cost of the components and applications development is low since they are widely used in different fields. Sensors and commercial modules have been combined with other self-developed modules. The Modular Volcano Monitoring System (MVMS) described has been deployed on the active Deception Island (Antarctica) volcano, within the Spanish Antarctic Program, and has proved successful for monitoring the volcano, with proven reliability and efficient operation under extreme conditions. In another context, i.e., the recent volcanic activity on El <span class="hlt">Hierro</span> Island (Canary Islands) in 2011, this technology has been used for the seismic equipment and GPS systems deployed, thus showing its efficiency in the monitoring of a volcanic crisis.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3926581','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3926581"><span>Embedded ARM System for Volcano Monitoring in Remote Areas: Application to the Active Volcano on Deception Island (Antarctica)</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Peci, Luis Miguel; Berrocoso, Manuel; Fernández-Ros, Alberto; García, Alicia; Marrero, José Manuel; Ortiz, Ramón</p> <p>2014-01-01</p> <p>This paper describes the development of a multi-parameter system for monitoring volcanic activity. The system permits the remote access and the connection of several modules in a network. An embedded ARM™™ processor has been used, allowing a great flexibility in hardware configuration. The use of a complete Linux solution (Debian™) as Operating System permits a quick, easy application development to control sensors and communications. This provides all the capabilities required and great stability with relatively low energy consumption. The cost of the components and applications development is low since they are widely used in different fields. Sensors and commercial modules have been combined with other self-developed modules. The Modular Volcano Monitoring System (MVMS) described has been deployed on the active Deception Island (Antarctica) volcano, within the Spanish Antarctic Program, and has proved successful for monitoring the volcano, with proven reliability and efficient operation under extreme conditions. In another context, i.e., the recent volcanic activity on El <span class="hlt">Hierro</span> Island (Canary Islands) in 2011, this technology has been used for the seismic equipment and GPS systems deployed, thus showing its efficiency in the monitoring of a volcanic crisis. PMID:24451461</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26826777','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26826777"><span>[Impact of the incorporation of a nurse in an inflammatory bowel disease unit].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Amo, Leticia; González-Lama, Yago; Suárez, Cristina; Blázquez, Isabel; Matallana, Virginia; Calvo, Marta; de la Revilla, Juan; Vera, María I; Abreu, Luis</p> <p>2016-05-01</p> <p>Multidisciplinary units are needed because of the growing complexity and volume of patients with inflammatory bowel disease (IBD). To evaluate the healthcare, economic and research impact of incorporating a nurse into the IBD unit of the Puerta de <span class="hlt">Hierro</span> Majadahonda University Hospital. We prospectively recorded the activity carried out by the nurse of the IBD unit from March 2010 to December 2014. During this period, healthcare demand progressively increased, with 1,558 patients being attended by our unit. The healthcare provided by the nurse included 5,293 electronic mails and 678 telephone calls. We estimated that this activity represented a saving of 3,504 in-person medical consultations and 852 accident and emergency department visits. Other activities consisted of monitoring treatments with biological and non-biological agents (8,371 laboratory tests), extraction of 342 blood samples, follow-up of 1047 diagnostic tests and consultations with other medical specialties, health education in self-administration of drugs in 114 patients, the performance of 158 granulocyte apheresis procedures, and participation in 25 research projects. The incorporation of a specialised nurse in an IBD unit had major economic, healthcare and research benefits. Copyright © 2016. Published by Elsevier Espana.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27305509','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27305509"><span>[Microbiología, sensibilidad antibiótica y factores asociados a bacteriemia en la prostatitis <span class="hlt">aguda</span>].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ferré, C; Llopis, F; Jacob, J</p> <p>2016-08-01</p> <p>The aim of the study was to analyze the characteristics of patients with acute prostatitis presenting to the Emergency Department, the microbiological findings, antibiotic susceptibility, and bacteraemia associated factors. Observational and cohort study with prospective follow-up including patients with acute prostatitis presenting to the Emergency Department from January-December 2012. Data were collected for demographic variables, comorbidities, microbiological findings, antibiotic treatment and outcome. Two hundred and forty one episodes of acute prostatitis were included. Mean age was 62.9 ± 16 years, a history of prostate adenoma was reported in 54 cases (22.5%) and prior manipulation of the lower urinary tract in 40 (17%). Mean symptoms duration was 3.38 ± 4.04 days, voiding symptoms were present in 176 cases (73%) and fever in 154 (64%). Seventy patients (29%) were admitted to the hospital and 3 died. From 216 urine cultures, 128 were positive (59%) and 24 (17.6%) out of 136 blood cultures. Escherichia coli was the main pathogen (58.6% of urine cultures and 64% of blood cultures) with resistant strains to fluoroquinolones, cotrimoxazole and amoxicillin/clavulanic in 27.7%, 22.9% and 27.7% of cases respectively. In the univariate analysis, only chills were associated to bacteraemia (p=0.013). At 30-day follow-up, patients with bacteraemia returned more frequently to the Emergency Department (p=0.037) and were more often admitted to the hospital (p=0.003). Patients with acute prostatitis discharged from the Emergency Department need clinical follow-up and monitoring of microbiological findings in order to assure an adequate antibiotic treatment. Return to Emergency Department and admission to the hospital were significantly more frequent among patients with bacteraemia.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2009EGUGA..11.6378A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2009EGUGA..11.6378A"><span>New insights into ocean tide loading corrections on tidal gravity data in Canary Islands</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Arnoso, J.; Benavent, M.; Bos, M. S.; Montesinos, F. G.</p> <p>2009-04-01</p> <p>The Canary Islands are an interesting area to investigate ocean tides loading effects due to the complex coastline of the islands and the varying bathymetry. We present here the quality of five recent global oceanic tidal models, GOT00.2, GOT4.7, FES2004, TPXO.7.1 and AG2006, by comparing their predicted ocean tide loading values with results from tidal gravity observations made on three islands, Lanzarote, Tenerife and El <span class="hlt">Hierro</span>, for the four harmonic constituents O1, K1, M2 and S2. In order to improve the accuracy of the loading corrections on the gravity tide measurements, we have used the high resolution regional oceanic model CIAM2 to supplement the global models considered here. This regional model has been obtained by assimilating TOPEX/Poseidon altimetry at crossovers and along-track points and tide gauge observations into a hydrodynamic model. The model has a 5'Ã-5' resolution and covers the area between the coordinates 26°.5N to 30°.0N and 19°.0W to 12°.5W. The gravity tide observing sites have been occupied by three different LaCoste&Romberg (LCR) spring gravimeters during different periods of observation. We considered here the most recent gravity tide observations made with LCR Graviton-EG1194 in El <span class="hlt">Hierro</span> Island, for a period of 6 months during 2008. In the case of Tenerife and Lanzarote sites we have used observation periods of 6 months and 8 years with LCR-G665 and LCR-G434 gravimeters, respectively. The last two sites have been revisited in order to improve the previous tidal analysis results. Thus, the gravity ocean tide loading corrections, based on the five global ocean tide models supplemented with the regional model CIAM2 allowed us to review the normalization factors (scale factor and phase lag) of both two gravimeters. Also, we investigated the discrepancies of the corrected gravimetric factors with the DDW elastic and inelastic non hydrostatic body tide model (Dehant et al., 1999). The lowest values are found for inelastic model in the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUFMNG13A1702Q','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUFMNG13A1702Q"><span>Is volcanic phenomena of fractal nature?</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Quevedo, R.; Lopez, D. A. L.; Alparone, S.; Hernandez Perez, P. A.; Sagiya, T.; Barrancos, J.; Rodriguez-Santana, A. A.; Ramos, A.; Calvari, S.; Perez, N. M.</p> <p>2016-12-01</p> <p>A particular resonance waveform pattern has been detected beneath different physical volcano manifestations from recent 2011-2012 period of volcanic unrest at El <span class="hlt">Hierro</span> Island, Canary Islands, and also from other worldwide volcanoes with different volcanic typology. This mentioned pattern appears to be a fractal time dependent waveform repeated in different time scales (periods of time). This time dependent feature suggests this resonance as a new approach to volcano phenomena for predicting such interesting matters as earthquakes, gas emission, deformation etc. as this fractal signal has been discovered hidden in a wide typical volcanic parameters measurements. It is known that the resonance phenomenon occurring in nature usually denote a structure, symmetry or a subjacent law (Fermi et al., 1952; and later -about enhanced cross-sections symmetry in protons collisions), which, in this particular case, may be indicative of some physical interactions showing a sequence not completely chaotic but cyclic provided with symmetries. The resonance and fractal model mentioned allowed the authors to make predictions in cycles from a few weeks to months. In this work an equation for this waveform has been described and also correlations with volcanic parameters and fractal behavior demonstration have been performed, including also some suggestive possible explanations of this signal origin.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23384391','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23384391"><span>Genetic characterization, at the mitochondrial and nuclear DNA levels, of five Canary Island dog breeds.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Suárez, N M; Betancor, E; Fregel, R; Pestano, J</p> <p>2013-08-01</p> <p>Many studies presenting genetic analysis of dog breeds have been conducted without the inclusion of island dog breeds, although isolation can be one of the main factors in their origin. Here we report the genetic analysis at the nuclear and mitochondrial DNA levels of five Canary Island dog breeds (Canarian Warren Hound, Canary Island Mastiff, Garafiano Shepherd, La Palma Rat-Hunter and El <span class="hlt">Hierro</span> Wolfhound) to fill this gap and, at the same time, genetically characterize these breeds. We identified 168 alleles in autosomal microsatellites and 16 mitochondrial haplotypes. Observed and expected heterozygosities ranged from 0.556 to 0.783 and from 0.737 to 0.943 respectively. Furthermore, three haplotypes were newly described and exclusive to a particular breed (A17+ in the Canary Island Mastiff; A33+ in the Canarian Warren Hound; Bi in the La Palma Rat-Hunter). The outcome of our analyses also revealed different breed histories consistent with historical documents and hypothetical origin designations. Although mtDNA haplotypes showed poor breed discriminating power, autosomal markers allowed a clear clustering of each single population. We expect that our results, together with further analyses, will help to make the population histories of island dog breeds clearer. © 2013 The Authors, Animal Genetics © 2013 Stichting International Foundation for Animal Genetics.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28035670','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28035670"><span>Morphological and molecular study of the cyanobiont-bearing dinoflagellate Sinophysis canaliculata from the Canary Islands (eastern central Atlantic).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>García-Portela, María; Riobó, Pilar; Rodríguez, Francisco</p> <p>2017-04-01</p> <p>The presence of the benthic dinophysoid dinoflagellate Sinophysis canaliculata has been reported in the Canary Islands (eastern central Atlantic) in live field observations and on fixed macroalgal samples from intertidal ponds (26 sampling sites from El <span class="hlt">Hierro</span>, Tenerife, Gran Canaria, Fuerteventura and Lanzarote islands). In vivo Sinophysis cells were typically pale pink colored. Light microscopy and scanning electron microscopy micrographs showed a small characteristic narrow hypothecal cut that matched the original description of S. canaliculata. SSU rRNA gene (rDNA) nuclear phylogeny showed that S. canaliculata is closely related to S. microcephalus. Sinophysis specimens displayed cyanobacterial endosymbionts with orange autofluorescence from phycoerythrins. SSU rDNA analyses of the cyanobionts nearly matched a former sequence obtained from S. canaliculata in the Pacific Ocean (Japan). S. canaliculata survived up to 5 months in the original seawater samples. During that period cyanobionts were always present and maintained their orange autofluorescence, although the pink color gradually vanished (<1 month) in most individuals. Molecular similarity of Sinophysis cyanobionts from the Canary Islands and Japanese waters suggest a deterministic relationship, likely a temporary maintenance inside their host via some specific grazing system. © 2016 Phycological Society of America.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12428457','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12428457"><span>Metallic content of wines from the Canary Islands (Spain). Application of artificial neural networks to the data analysis.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Frías, Sergio; Conde, José E; Rodríguez, Miguel A; Dohnal, Vlasta; Pérez-Trujillo, Juan P</p> <p>2002-10-01</p> <p>Eleven elements, K, Na, Ca, Mg, Fe, Cu, Zn, Mn, Sr, Li and Rb, were determined in dry and sweet wines bearing the denominations of origin of El <span class="hlt">Hierro</span>, La Palma and Lanzarote islands (Canary Islands, Spain). Analyses were performed by flame atomic absorption spectrophotometry, with the exceptions of Li and Rb for which flame atomic emission spectrophotometry was used. The content in copper and iron did not present risks of cases. All samples presented a copper and zinc content below the maximum amount recommended by the Office International de la Vigne et du Vin (OIV) for these elements. Significant differences in the metallic content were found among the different islands. Thus, Lanzarote presented the highest mean content in sodium and lithium and the lowest mean content in rubidium, and La Palma presented the highest mean content in strontium and rubidium. Sweet wines from La Palma, elaborated as naturally sweet with over-ripe grapes, presented mean contents significantly higher with regard to dry wines from the same island in the majority of the analysed elements. Cluster analysis and Kohonen self-organising maps showed differences in wines according to the island of origin and the ripening state of the grapes. Back-propagation artificial neural networks showed better prediction ability than stepwise linear discriminant analysis.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li class="active"><span>14</span></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_14 --> <div id="page_15" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li class="active"><span>15</span></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="281"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2806738','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2806738"><span>A protein secretion system linked to bacteroidete gliding motility and pathogenesis</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Sato, Keiko; Naito, Mariko; Yukitake, Hideharu; Hirakawa, Hideki; Shoji, Mikio; McBride, Mark J.; Rhodes, Ryan G.; Nakayama, Koji</p> <p>2009-01-01</p> <p>Porphyromonas gingivalis secretes strong proteases called gingipains that are implicated in periodontal pathogenesis. Protein secretion systems common to other Gram-negative bacteria are lacking in P. gingivalis, but several proteins, including <span class="hlt">Por</span>T, have been linked to gingipain secretion. Comparative genome analysis and genetic experiments revealed 11 additional proteins involved in gingipain secretion. Six of these (<span class="hlt">Por</span>K, <span class="hlt">Por</span>L, <span class="hlt">Por</span>M, <span class="hlt">Por</span>N, <span class="hlt">Por</span>W, and Sov) were similar in sequence to Flavobacterium johnsoniae gliding motility proteins, and two others (<span class="hlt">Por</span>X and <span class="hlt">Por</span>Y) were putative two-component system regulatory proteins. Real-time RT-PCR analysis revealed that <span class="hlt">por</span>K, <span class="hlt">por</span>L, <span class="hlt">por</span>M, <span class="hlt">por</span>N, <span class="hlt">por</span>P, <span class="hlt">por</span>T, and sov were down-regulated in P. gingivalis <span class="hlt">por</span>X and <span class="hlt">por</span>Y mutants. Disruption of the F. johnsoniae <span class="hlt">por</span>T ortholog resulted in defects in motility, chitinase secretion, and translocation of a gliding motility protein, SprB adhesin, to the cell surface, providing a link between a unique protein translocation system and a motility apparatus in members of the Bacteroidetes phylum. PMID:19966289</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4930169','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4930169"><span>Differential Regulation of Duplicate Light-Dependent Protochlorophyllide Oxidoreductases in the Diatom Phaeodactylum tricornutum</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Hunsperger, Heather M.; Cattolico, Rose Ann</p> <p>2016-01-01</p> <p>Background Diatoms (Bacilliariophyceae) encode two light-dependent protochlorophyllide oxidoreductases (<span class="hlt">POR</span>1 and <span class="hlt">POR</span>2) that catalyze the penultimate step of chlorophyll biosynthesis in the light. Algae live in dynamic environments whose changing light levels induce photoacclimative metabolic shifts, including altered cellular chlorophyll levels. We hypothesized that the two <span class="hlt">POR</span> proteins may be differentially adaptive under varying light conditions. Using the diatom Phaeodactylum tricornutum as a test system, differences in <span class="hlt">POR</span> protein abundance and <span class="hlt">por</span> gene expression were examined when this organism was grown on an alternating light:dark cycles at different irradiances; exposed to continuous light; and challenged by a significant decrease in light availability. Results For cultures maintained on a 12h light: 12h dark photoperiod at 200μE m−2 s−1 (200L/D), both <span class="hlt">por</span> genes were up-regulated during the light and down-regulated in the dark, though <span class="hlt">por</span>1 transcript abundance rose and fell earlier than that of <span class="hlt">por</span>2. Little concordance occurred between <span class="hlt">por</span>1 mRNA and <span class="hlt">POR</span>1 protein abundance. In contrast, <span class="hlt">por</span>2 mRNA and <span class="hlt">POR</span>2 protein abundances followed similar diurnal patterns. When 200L/D P. tricornutum cultures were transferred to continuous light (200L/L), the diurnal regulatory pattern of <span class="hlt">por</span>1 mRNA abundance but not of <span class="hlt">por</span>2 was disrupted, and <span class="hlt">POR</span>1 but not <span class="hlt">POR</span>2 protein abundance dropped steeply. Under 1200μE m−2 s−1 (1200L/D), both <span class="hlt">por</span>1 mRNA and <span class="hlt">POR</span>1 protein abundance displayed diurnal oscillations. A compromised diel <span class="hlt">por</span>2 mRNA response under 1200L/D did not impact the oscillation in <span class="hlt">POR</span>2 abundance. When cells grown at 1200L/D were then shifted to 50μE m−2 s−1 (50L/D), <span class="hlt">por</span>1 and <span class="hlt">por</span>2 mRNA levels decreased swiftly but briefly upon light reduction. Thereafter, <span class="hlt">POR</span>1 but not <span class="hlt">POR</span>2 protein levels rose significantly in response to this light stepdown. Conclusion Given the sensitivity of diatom <span class="hlt">por</span>1/<span class="hlt">POR</span>1 to real-time light cues and adherence of <span class="hlt">por</span>2/<span class="hlt">POR</span>2 regulation to</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4168388','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4168388"><span>Population pharmacokinetic approach to evaluate the effect of CYP2D6, CYP3A, ABCB1, <span class="hlt">POR</span> and NR1I2 genotypes on donepezil clearance</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Noetzli, Muriel; Guidi, Monia; Ebbing, Karsten; Eyer, Stephan; Wilhelm, Laurence; Michon, Agnès; Thomazic, Valérie; Stancu, Ioana; Alnawaqil, Abdel-Messieh; Bula, Christophe; Zumbach, Serge; Gaillard, Michel; Giannakopoulos, Panteleimon; von Gunten, Armin; Csajka, Chantal; Eap, Chin B</p> <p>2014-01-01</p> <p>Aims A large interindividual variability in plasma concentrations has been reported in patients treated with donepezil, the most frequently prescribed antidementia drug. We aimed to evaluate clinical and genetic factors influencing donepezil disposition in a patient population recruited from a naturalistic setting. Methods A population pharmacokinetic study was performed including data from 129 older patients treated with donepezil. The patients were genotyped for common polymorphisms in the metabolic enzymes CYP2D6 and CYP3A, in the electron transferring protein <span class="hlt">POR</span> and the nuclear factor NR1I2 involved in CYP activity and expression, and in the drug transporter ABCB1. Results The average donepezil clearance was 7.3 l h−1 with a 30% interindividual variability. Gender markedly influenced donepezil clearance (P < 0.01). Functional alleles of CYP2D6 were identified as unique significant genetic covariate for donepezil clearance (P < 0.01), with poor metabolizers and ultrarapid metabolizers demonstrating, respectively, a 32% slower and a 67% faster donepezil elimination compared with extensive metabolizers. Conclusion The pharmacokinetic parameters of donepezil were well described by the developed population model. Functional alleles of CYP2D6 significantly contributed to the variability in donepezil disposition in the patient population and should be further investigated in the context of individual dose optimization to improve clinical outcome and tolerability of the treatment. PMID:24433464</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24433464','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24433464"><span>Population pharmacokinetic approach to evaluate the effect of CYP2D6, CYP3A, ABCB1, <span class="hlt">POR</span> and NR1I2 genotypes on donepezil clearance.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Noetzli, Muriel; Guidi, Monia; Ebbing, Karsten; Eyer, Stephan; Wilhelm, Laurence; Michon, Agnès; Thomazic, Valérie; Stancu, Ioana; Alnawaqil, Abdel-Messieh; Bula, Christophe; Zumbach, Serge; Gaillard, Michel; Giannakopoulos, Panteleimon; von Gunten, Armin; Csajka, Chantal; Eap, Chin B</p> <p>2014-07-01</p> <p>A large interindividual variability in plasma concentrations has been reported in patients treated with donepezil, the most frequently prescribed antidementia drug. We aimed to evaluate clinical and genetic factors influencing donepezil disposition in a patient population recruited from a naturalistic setting. A population pharmacokinetic study was performed including data from 129 older patients treated with donepezil. The patients were genotyped for common polymorphisms in the metabolic enzymes CYP2D6 and CYP3A, in the electron transferring protein <span class="hlt">POR</span> and the nuclear factor NR1I2 involved in CYP activity and expression, and in the drug transporter ABCB1. The average donepezil clearance was 7.3 l h(-1) with a 30% interindividual variability. Gender markedly influenced donepezil clearance (P < 0.01). Functional alleles of CYP2D6 were identified as unique significant genetic covariate for donepezil clearance (P < 0.01), with poor metabolizers and ultrarapid metabolizers demonstrating, respectively, a 32% slower and a 67% faster donepezil elimination compared with extensive metabolizers. The pharmacokinetic parameters of donepezil were well described by the developed population model. Functional alleles of CYP2D6 significantly contributed to the variability in donepezil disposition in the patient population and should be further investigated in the context of individual dose optimization to improve clinical outcome and tolerability of the treatment. © 2014 The British Pharmacological Society.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1346608-differential-regulation-duplicate-light-dependent-protochlorophyllide-oxidoreductases-diatom-phaeodactylum-tricornutum','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1346608-differential-regulation-duplicate-light-dependent-protochlorophyllide-oxidoreductases-diatom-phaeodactylum-tricornutum"><span>Differential regulation of duplicate light-dependent protochlorophyllide oxidoreductases in the diatom Phaeodactylum tricornutum</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Hunsperger, Heather M.; Ford, Christopher J.; Miller, James S.; ...</p> <p>2016-07-01</p> <p>Diatoms (Bacilliariophyceae) encode two light-dependent protochlorophyllide oxidoreductases (<span class="hlt">POR</span>1 and <span class="hlt">POR</span>2) that catalyze the penultimate step of chlorophyll biosynthesis in the light. Algae live in dynamic environments whose changing light levels induce photoacclimative metabolic shifts, including altered cellular chlorophyll levels. We hypothesized that the two <span class="hlt">POR</span> proteins may be differentially adaptive under varying light conditions. Using the diatom Phaeodactylum tricornutum as a test system, differences in <span class="hlt">POR</span> protein abundance and <span class="hlt">por</span> gene expression were examined when this organism was grown on an alternating light:dark cycles at different irradiances; exposed to continuous light; and challenged by a significant decrease in light availability.more » As a result, for cultures maintained on a 12h light: 12h dark photoperiod at 200μEm –2 s –1 ( 200L/D), both <span class="hlt">por</span> genes were up-regulated during the light and down-regulated in the dark, though <span class="hlt">por</span>1 transcript abundance rose and fell earlier than that of <span class="hlt">por</span>2. Little concordance occurred between <span class="hlt">por</span>1 mRNA and <span class="hlt">POR</span>1 protein abundance. In contrast, <span class="hlt">por</span>2 mRNA and <span class="hlt">POR</span>2 protein abundances followed similar diurnal patterns. When 200L/D P. tricornutum cultures were transferred to continuous light ( 200L/L), the diurnal regulatory pattern of <span class="hlt">por</span>1 mRNA abundance but not of <span class="hlt">por</span>2 was disrupted, and <span class="hlt">POR</span>1 but not <span class="hlt">POR</span>2 protein abundance dropped steeply. Under 1200μEm –2 s –1 ( 1200L/D), both <span class="hlt">por</span>1 mRNA and <span class="hlt">POR</span>1 protein abundance displayed diurnal oscillations. A compromised diel <span class="hlt">por</span>2 mRNA response under 1200L/D did not impact the oscillation in <span class="hlt">POR</span>2 abundance. When cells grown at 1200L/D were then shifted to 50μEm –2 s –1 (50L/D), <span class="hlt">por</span>1 and <span class="hlt">por</span>2 mRNA levels decreased swiftly but briefly upon light reduction. Thereafter, <span class="hlt">POR</span>1 but not <span class="hlt">POR</span>2 protein levels rose significantly in response to this light stepdown.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005AGUSM.P21D..06J','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005AGUSM.P21D..06J"><span>Comparing Time Domain Electromagnetics (TEM) and Early-Time TEM for Mapping Highly Conductive Groundwater in Mars Analog Environments</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Jernsletten, J. A.</p> <p>2005-05-01</p> <p>Introduction: The purpose of this study is to evaluate the use of (diffusive) Time Domain Electromagnetics (TEM) for sounding of subsurface water in conductive Mars analog environments. To provide a baseline for such studies, I show data from two field studies: 1) Diffusive sounding data (TEM) from Pima County, Arizona; and 2) Shallower sounding data using the Fast-Turnoff TEM method from Peña de <span class="hlt">Hierro</span> in the Rio Tinto region of Spain. The latter is data from work conducted under the auspices of the Mars Analog Research and Technology Experiment (MARTE). Pima County TEM Survey: A TEM survey was carried out in Pima County, Arizona, in January 2003. Data was collected using 100 m Tx loops and a ferrite-cored magnetic coil Rx antenna, and processed using commercial software. The survey used a 16 Hz sounding frequency, which is sensitive to slightly salty groundwater. Prominent features in the data from Arizona are the ~500 m depth of investigation and the ~120 m depth to the water table, confirmed by data from four USGS test wells surrounding the field area. Note also the conductive (~20-40 ω m) clay-rich soil above the water table. Rio Tinto Fast-Turnoff TEM Survey: During May and June of 2003, a Fast-Turnoff (early time) TEM survey was carried out at the Peña de <span class="hlt">Hierro</span> field area of the MARTE project, near the town of Nerva, Spain. Data was collected using 20 m and 40 m Tx loop antennae and 10 m loop Rx antennae, with a 32 Hz sounding frequency. Data from Line 4 (of 16) from this survey, collected using 40 m Tx loops, show ~200 m depth of investigation and a conductive high at ~90 m depth below Station 20 (second station of 10 along this line). This is the water table, matching the 431 m MSL elevation of the nearby pit lake. The center of the "pileup" below Station 60 is spatially coincident with the vertical fault plane located here. Data from Line 15 and Line 14 of the Rio Tinto survey, collected using 20 m Tx loops, achieve ~50 m depth of investigation and</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/20991269-study-stability-sub-oxometalloporphyrins-first-principles-calculations','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/20991269-study-stability-sub-oxometalloporphyrins-first-principles-calculations"><span>A study on the stability of O{sub 2} on oxometalloporphyrins by the first principles calculations</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Kubota, Yoshiyuki; Escano, Mary Clare Sison; Dy, Eben Sy</p> <p>2007-05-21</p> <p>The authors investigated the interaction of oxometalloporphyrins (MO(<span class="hlt">por</span>))--specifically, MoO(<span class="hlt">por</span>), WO(<span class="hlt">por</span>), TiO(<span class="hlt">por</span>), VO(<span class="hlt">por</span>), and CrO(<span class="hlt">por</span>)--with O{sub 2} by using first principles calculations. MoO(<span class="hlt">por</span>) and WO(<span class="hlt">por</span>) undergo reactions with O{sub 2}; on the other hand, TiO(<span class="hlt">por</span>), VO(<span class="hlt">por</span>), and CrO(<span class="hlt">por</span>) do not. Next, they compared the interaction of MoO(<span class="hlt">por</span>) and WO(<span class="hlt">por</span>) with O{sub 2}. Activation barriers for the reactions of MoO(<span class="hlt">por</span>) and WO(<span class="hlt">por</span>) with a side-on O{sub 2} are small. For MoO(<span class="hlt">por</span>)(O{sub 2}), the activation barrier for the reverse reaction that liberates O{sub 2} is also small; however, that for WO(<span class="hlt">por</span>)(O{sub 2}) is large. The experimental results that photoirradiation with visible light ormore » heating of Mo {sup VI}O(tmp)(O{sub 2}) regenerates Mo {sup VI}O(tmp) by liberating O{sub 2} while W {sup VI}O(tmp)(O{sub 2}) does not [J. Tachibana, T. Imamura, and Y. Sasaki, Bull. Chem. Soc. Jpn. 71, 363 (1998)] are explained by the difference in activation barriers of the reverse reactions. This means that bonds formed between the W atom and O{sub 2} are stronger than those between the Mo atom and O{sub 2}. The bond strengths can be explained by differences in the energy levels between the highest occupied molecular orbital of MoO(<span class="hlt">por</span>) and WO(<span class="hlt">por</span>), which are mainly formed from the a orbitals of the central metal atom and {pi}{sup *} orbitals of O{sub 2}.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/18775254','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/18775254"><span>[Clinical and functional characteristics of patients prior to lung transplantation: report of experience at the Clínica Puerta de <span class="hlt">Hierro</span>].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Laporta, Rosalía; Ussetti, Piedad; Mora, Gema; López, Cristina; Gómez, David; de Pablo, Alicia; Lázaro, M Teresa; Carreño, M Cruz; Ferreiro, M José</p> <p>2008-08-01</p> <p>The time at which lung transplantation is indicated is determined by clinical and functional criteria that vary according to the particular disease. The aim of our study was to present the criteria according to which patients were placed on waiting lists for lung transplantation in our hospital. We analyzed retrospectively the clinical characteristics, lung function, heart function, and 6-minute walk test results of patients who had received a lung transplant in our hospital from January 2002 through September 2005. During the study period 100 lung transplants were performed. The mean age of the patients was 45 years (range, 15-67 years) and 57% were men. The diseases that most often led to a lung transplant were chronic obstructive pulmonary disease (COPD) (35%), pulmonary fibrosis (29%), and bronchiectasis (21%). Lung function values differed by disease: mean (SD) forced expiratory volume in 1 second (FEV1) was 20% (11%) and forced vital capacity (FVC) was 37% (15%) in patients with COPD; FEV1 was 41% (15%) and FVC, 40% (17%) in patients with pulmonary fibrosis; and FEV1 was 23% (7%) and FVC, 37% (10%) in patients with bronchiectasis. The patients who received lung transplants in our hospital were in advanced phases of their disease and met the inclusion criteria accepted by the various medical associations when they were placed on the waiting list.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28714554','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28714554"><span>Type IX secretion: the generation of bacterial cell surface coatings involved in virulence, gliding motility and the degradation of complex biopolymers.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Veith, Paul D; Glew, Michelle D; Gorasia, Dhana G; Reynolds, Eric C</p> <p>2017-10-01</p> <p>The Type IX secretion system (T9SS) is present in over 1000 sequenced species/strains of the Fibrobacteres-Chlorobi-Bacteroidetes superphylum. Proteins secreted by the T9SS have an N-terminal signal peptide for translocation across the inner membrane via the SEC translocon and a C-terminal signal for secretion across the outer membrane via the T9SS. Nineteen protein components of the T9SS have been identified including three, SigP, <span class="hlt">Por</span>X and <span class="hlt">Por</span>Y that are involved in regulation. The inner membrane proteins <span class="hlt">Por</span>L and <span class="hlt">Por</span>M and the outer membrane proteins <span class="hlt">Por</span>K and <span class="hlt">Por</span>N interact and a complex comprising <span class="hlt">Por</span>K and <span class="hlt">Por</span>N forms a large ring structure of 50 nm in diameter. <span class="hlt">Por</span>U, <span class="hlt">Por</span>V, <span class="hlt">Por</span>Q and <span class="hlt">Por</span>Z form an attachment complex on the cell surface of the oral pathogen, Porphyromonas gingivalis. P. gingivalis T9SS substrates bind to <span class="hlt">Por</span>V suggesting that after translocation <span class="hlt">Por</span>V functions as a shuttle protein to deliver T9SS substrates to the attachment complex. The <span class="hlt">Por</span>U component of the attachment complex is a novel Gram negative sortase which catalyses the cleavage of the C-terminal signal and conjugation of the protein substrates to lipopolysaccharide, anchoring them to the cell surface. This review presents an overview of the T9SS focusing on the function of T9SS substrates and machinery components. © 2017 John Wiley & Sons Ltd.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2008AsBio...8..921S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2008AsBio...8..921S"><span>The 2005 MARTE Robotic Drilling Experiment in Río Tinto, Spain: Objectives, Approach, and Results of a Simulated Mission to Search for Life in the Martian Subsurface</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Stoker, Carol R.; Cannon, Howard N.; Dunagan, Stephen E.; Lemke, Lawrence G.; Glass, Brian J.; Miller, David; Gomez-Elvira, Javier; Davis, Kiel; Zavaleta, Jhony; Winterholler, Alois; Roman, Matt; Rodriguez-Manfredi, Jose Antonio; Bonaccorsi, Rosalba; Bell, Mary Sue; Brown, Adrian; Battler, Melissa; Chen, Bin; Cooper, George; Davidson, Mark; Fernández-Remolar, David; Gonzales-Pastor, Eduardo; Heldmann, Jennifer L.; Martínez-Frías, Jesus; Parro, Victor; Prieto-Ballesteros, Olga; Sutter, Brad; Schuerger, Andrew C.; Schutt, John; Rull, Fernando</p> <p>2008-10-01</p> <p>The Mars Astrobiology Research and Technology Experiment (MARTE) simulated a robotic drilling mission to search for subsurface life on Mars. The drill site was on Peña de <span class="hlt">Hierro</span> near the headwaters of the Río Tinto river (southwest Spain), on a deposit that includes massive sulfides and their gossanized remains that resemble some iron and sulfur minerals found on Mars. The mission used a fluidless, 10-axis, autonomous coring drill mounted on a simulated lander. Cores were faced; then instruments collected color wide-angle context images, color microscopic images, visible near infrared point spectra, and (lower resolution) visible-near infrared hyperspectral images. Cores were then stored for further processing or ejected. A borehole inspection system collected panoramic imaging and Raman spectra of borehole walls. Life detection was performed on full cores with an adenosine triphosphate luciferin-luciferase bioluminescence assay and on crushed core sections with SOLID2, an antibody array-based instrument. Two remotely located science teams analyzed the remote sensing data and chose subsample locations. In 30 days of operation, the drill penetrated to 6 m and collected 21 cores. Biosignatures were detected in 12 of 15 samples analyzed by SOLID2. Science teams correctly interpreted the nature of the deposits drilled as compared to the ground truth. This experiment shows that drilling to search for subsurface life on Mars is technically feasible and scientifically rewarding.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2009AGUFM.T13B1859M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2009AGUFM.T13B1859M"><span>The Lithospheric Structure Beneath Canary Islands from Receiver Function Analysis</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Martinez-Arevalo, C.; Mancilla, F.; Helffrich, G. R.; Garcia, A.</p> <p>2009-12-01</p> <p>The Canary Archipelago is located a few hundred kilometers off the western Moroccan coast, extending 450 km west-to-east. It is composed of seven main islands. All but one have been active in the last million years. The origin of the Canary Islands is not well established and local and regional geology features cannot be completely explained by the current models. The main aim of this study is to provide new data that help us to understand and constrain the archipelago's origin and tectonic evolution. The crustal structure under each station is obtained applying P-receiver function technique to the teleseismic P arrivals recorded by the broadband seismic network installed at the Canary Island by the Instituto Geográfico Nacional (IGN) and two temporary stations (MIDSEA and IRIS). We computed receiver functions using the Extended-Time Multitaper Frequency Domain Cross-Correlation Receiver Function (ET-MTRF) method. The results show that the crust is thicker, around 22 km, in the eastern islands (Fuerteventura and Lanzarote) than in the western ones (El <span class="hlt">Hierro</span>, La Palma, Tenerife), around 17 km, with the exception of La Gomera island. This island, located in the west, exhibits similar crustal structure to Fuerteventura and Lanzarote. A discontinuity at 70-80 km, possibly the LAB (Lithosphere Asthenosphere Boundary) is clearly observed in all the stations. It appears that Moho depths do not track the LAB discontinuity.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4182500','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4182500"><span>Effects of Ocean Acidification on the Brown Alga Padina pavonica: Decalcification Due to Acute and Chronic Events</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Gil-Díaz, Teba; Haroun, Ricardo; Tuya, Fernando; Betancor, Séfora; Viera-Rodríguez, María A.</p> <p>2014-01-01</p> <p>Since the industrial revolution, anthropogenic CO2 emissions have caused ocean acidification, which particularly affects calcified organisms. Given the fan-like calcified fronds of the brown alga Padina pavonica, we evaluated the acute (short-term) effects of a sudden pH drop due to a submarine volcanic eruption (October 2011–early March 2012) affecting offshore waters around El <span class="hlt">Hierro</span> Island (Canary Islands, Spain). We further studied the chronic (long-term) effects of the continuous decrease in pH in the last decades around the Canarian waters. In both the observational and retrospective studies (using herbarium collections of P. pavonica thalli from the overall Canarian Archipelago), the percent of surface calcium carbonate coverage of P. pavonica thalli were contrasted with oceanographic data collected either in situ (volcanic eruption event) or from the ESTOC marine observatory data series (herbarium study). Results showed that this calcified alga is sensitive to acute and chronic environmental pH changes. In both cases, pH changes predicted surface thallus calcification, including a progressive decalcification over the last three decades. This result concurs with previous studies where calcareous organisms decalcify under more acidic conditions. Hence, Padina pavonica can be implemented as a bio-indicator of ocean acidification (at short and long time scales) for monitoring purposes over wide geographic ranges, as this macroalga is affected and thrives (unlike strict calcifiers) under more acidic conditions. PMID:25268231</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19032053','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19032053"><span>The 2005 MARTE Robotic Drilling Experiment in Río Tinto, Spain: objectives, approach, and results of a simulated mission to search for life in the Martian subsurface.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stoker, Carol R; Cannon, Howard N; Dunagan, Stephen E; Lemke, Lawrence G; Glass, Brian J; Miller, David; Gomez-Elvira, Javier; Davis, Kiel; Zavaleta, Jhony; Winterholler, Alois; Roman, Matt; Rodriguez-Manfredi, Jose Antonio; Bonaccorsi, Rosalba; Bell, Mary Sue; Brown, Adrian; Battler, Melissa; Chen, Bin; Cooper, George; Davidson, Mark; Fernández-Remolar, David; Gonzales-Pastor, Eduardo; Heldmann, Jennifer L; Martínez-Frías, Jesus; Parro, Victor; Prieto-Ballesteros, Olga; Sutter, Brad; Schuerger, Andrew C; Schutt, John; Rull, Fernando</p> <p>2008-10-01</p> <p>The Mars Astrobiology Research and Technology Experiment (MARTE) simulated a robotic drilling mission to search for subsurface life on Mars. The drill site was on Peña de <span class="hlt">Hierro</span> near the headwaters of the Río Tinto river (southwest Spain), on a deposit that includes massive sulfides and their gossanized remains that resemble some iron and sulfur minerals found on Mars. The mission used a fluidless, 10-axis, autonomous coring drill mounted on a simulated lander. Cores were faced; then instruments collected color wide-angle context images, color microscopic images, visible-near infrared point spectra, and (lower resolution) visible-near infrared hyperspectral images. Cores were then stored for further processing or ejected. A borehole inspection system collected panoramic imaging and Raman spectra of borehole walls. Life detection was performed on full cores with an adenosine triphosphate luciferin-luciferase bioluminescence assay and on crushed core sections with SOLID2, an antibody array-based instrument. Two remotely located science teams analyzed the remote sensing data and chose subsample locations. In 30 days of operation, the drill penetrated to 6 m and collected 21 cores. Biosignatures were detected in 12 of 15 samples analyzed by SOLID2. Science teams correctly interpreted the nature of the deposits drilled as compared to the ground truth. This experiment shows that drilling to search for subsurface life on Mars is technically feasible and scientifically rewarding.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/9688513','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/9688513"><span>A new derived and highly polymorphic chromosomal race of Liolaemus monticola (Iguanidae) from the 'Norte Chico' of Chile.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lamborot, M</p> <p>1998-06-01</p> <p>A multiple Robertsonian fission chromosomal race of the Liolaemus monticola complex in Chile is described and is shown to be the most derived and the most complex among the Liolaemus examined thus far. The 29 karyotyped lizards analysed from the locality of Mina <span class="hlt">Hierro</span> Viejo, Petorca, Provincia de Valparaiso, Chile, exhibited a diploid chromosomal number ranging from 42 to 44, and several polymorphisms. The polymorphisms included: a pair 1 fission; a pair 2 fission plus a pericentric inversion in one of the fission products, which moved the NOR and satellite from the tip of the long arm of the metacentric 2 to the short arm of the fission product; a fission in pair 3; a polymorphism for an enlarged chromosome pair 6; and a polymorphism for a pericentric inversion in pair 7. This population is fixed for a fission of chromosome pair 4. A total of 76% of the lizards analysed were polymorphic for one or more pairs of chromosomes. We have compared these data with other Liolaemus monticola chromosomal races and calculated the Hardy-Weinberg ratios for the polymorphic chromosome pairs in this Multiple-Fission race. Karyotypic differences between the Northern (2n = 38-40) and the Multiple-Fission (2n = 42-44) races were attributed mainly to Robertsonian fissions, an enlarged chromosome and pericentric inversions involving the macrochromosomes and one microchromosome pair.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21715203','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21715203"><span>The effect of β-saturated pyrrolic rings on the electronic structures and aromaticity of magnesium porphyrin derivatives: a density functional study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wan, Liang; Qi, Dongdong; Zhang, Yuexing</p> <p>2011-09-01</p> <p>Density functional theory (DFT) calculation on the molecular structures, molecular orbitals, electronic absorption spectra, and magnetic properties of magnesium porphyrin (Mg<span class="hlt">Por</span>) and a series of five hydrogenated magnesium porphyrin complexes with different number of β-saturated pyrrolic rings, namely Mg<span class="hlt">Por</span>-β-1Hy, Mg<span class="hlt">Por</span>-β-opp-2Hy, Mg<span class="hlt">Por</span>-β-adj-2Hy, Mg<span class="hlt">Por</span>-β-3Hy, and Mg<span class="hlt">Por</span>-β-4Hy, clarifies the red-shift of the lowest energy absorption band from chlorophyll a to bacteriochlorophyll and reveals the strong chemical stability for both of them. The energy levels of highest occupied molecular orbitals (HOMO) and HOMO-1 for Mg<span class="hlt">Por</span> are reversed upon hydrogenation at β-positions (2 and 3, 7 and 8, 12 and 13, and 17 and 18) of porphyrin ring. Along with the increase of β-saturated pyrrolic rings from 1, 2, 3, to 4, the HOMO energy increases from -4.78 eV to -3.10 eV in a regular manner. In contrast, the lowest unoccupied molecular orbitals (LUMO) energy levels of Mg<span class="hlt">Por</span>, Mg<span class="hlt">Por</span>-β-1Hy, and Mg<span class="hlt">Por</span>-β-opp-2Hy are very similar with each other. As a result, the lowest energy absorption band involving main transition from HOMO to LUMO is red-shifted from Mg<span class="hlt">Por</span>-β-1Hy to Mg<span class="hlt">Por</span>-β-opp-2Hy which is representative of chlorophyll a and bacteriochlorophyll, respectively. Natural hydroporphyrins represented by Mg<span class="hlt">Por</span>, Mg<span class="hlt">Por</span>-β-1Hy, and Mg<span class="hlt">Por</span>-β-opp-2Hy have turned out to be aromatic and stable enough, in good accordance with the ubiquity of their derivatives in the nature. In contrast, Mg<span class="hlt">Por</span>-β-adj-2Hy, Mg<span class="hlt">Por</span>-β-3Hy, and Mg<span class="hlt">Por</span>-β-4Hy with relatively weak aromaticity seem to be unstable and therefore were not found in nature. Copyright © 2011 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28630545','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28630545"><span>Legal Knowledge as a Tool for Social Change: La Mesa <span class="hlt">por</span> la Vida y la Salud de las Mujeres as an Expert on Colombian Abortion Law.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>González Vélez, Ana Cristina; Jaramillo, Isabel Cristina</p> <p>2017-06-01</p> <p>In May 2006, Colombia's Constitutional Court liberalized abortion, introducing three circumstances under which the procedure would not be considered a crime: (1) rape or incest; (2) a risk to the woman's health or life; and (3) fetal malformations incompatible with life. Immediately following the court's ruling, known as Sentence C-355, members of La Mesa <span class="hlt">por</span> la Vida y Salud de las Mujeres (hereinafter La Mesa) began to mobilize to ensure the decision's implementation, bearing in mind the limited impact that the legal framework endorsed by the court has had in other countries in the region. We argue that La Mesa's strategy is an innovative one in the field of legal mobilization insofar as it presumes that law can be shaped not just by public officials and universities but also by social actors engaged in the creation and diffusion of legal knowledge. In this regard, La Mesa has become a legal expert on abortion by accumulating knowledge about the multiple legal rules affecting the practice of abortion and about the situations in which these rules are to be applied. In addition, by becoming a legal expert, La Mesa has been able to persuade health providers that they will not risk criminal prosecution or being fired if they perform abortions. We call this effect of legal mobilization a "pedagogical effect" insofar as it involves the production of expertise and appropriation of knowledge by health professionals. We conclude by discussing La Mesa's choice to become a legal expert on abortion as opposed to recruiting academics to do this work or encouraging women to produce and disseminate this knowledge.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29949783','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29949783"><span>Effect of P450 Oxidoreductase Polymorphisms on the Metabolic Activities of Ten Cytochrome P450s Varied by Polymorphic CYP Genotypes in Human Liver Microsomes.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Fang, Yan; Gao, Na; Tian, Xin; Zhou, Jun; Zhang, Hai-Feng; Gao, Jie; He, Xiao-Pei; Wen, Qiang; Jia, Lin-Jing; Jin, Han; Qiao, Hai-Ling</p> <p>2018-06-27</p> <p>Background/ Aims: Little is known about the effect of P450 oxidoreductase (<span class="hlt">POR</span>) gene polymorphisms on the activities of CYPs with multiple genotypes. We genotyped 102 human livers for 18 known <span class="hlt">POR</span> single nucleotide polymorphisms (SNPs) with allelic frequencies greater than 1% as well as for 27 known SNPs in 10 CYPs. CYP enzyme activities in microsomes prepared from these livers were determined by measuring probe substrate metabolism by high performance liquid chromatograph. We found that the effects of the 18 <span class="hlt">POR</span> SNPs on 10 CYP activities were CYP genotype-dependent. The <span class="hlt">POR</span> mutations were significantly associated with decreased overall Km for CYP2B6 and 2E1, and specific genotypes within CYP1A2, 2A6, 2B6, 2C8, 2D6 and 2E1 were identified as being affected by these <span class="hlt">POR</span> SNPs. Notably, the effect of a specific <span class="hlt">POR</span> mutation on the activity of a CYP genotype could not be predicted from other CYP genotypes of even the same CYP. When combining one <span class="hlt">POR</span> SNP with other <span class="hlt">POR</span> SNPs, a hitherto unrecognized effect of multiple-site <span class="hlt">POR</span> gene polymorphisms (MSGP) on CYP activity was uncovered, which was not necessarily consistent with the effect of either single <span class="hlt">POR</span> SNP. The effects of <span class="hlt">POR</span> SNPs on CYP activities were not only CYP-dependent, but more importantly, CYP genotype-dependent. Moreover, the effect of a <span class="hlt">POR</span> SNP alone and in combination with other <span class="hlt">POR</span> SNPs (MSGP) was not always consistent, nor predictable. Understanding the impact of <span class="hlt">POR</span> gene polymorphisms on drug metabolism necessitates knowing the complete SNP complement of <span class="hlt">POR</span> and the genotype of the relevant CYPs. © 2018 The Author(s). Published by S. Karger AG, Basel.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012CoMP..164..177D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012CoMP..164..177D"><span>Oxygen isotope heterogeneity of the mantle beneath the Canary Islands: a discussion of the paper of Gurenko et al.</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Day, James M. D.; Macpherson, Colin G.; Lowry, David; Pearson, D. Graham</p> <p>2012-07-01</p> <p>Gurenko et al. (Contrib Mineral Petrol 162:349-363, 2011) report laser-assisted fluorination (LF) and secondary ionization mass spectrometry (SIMS) 18O/16O datasets for olivine grains from the Canary Islands of Gran Canaria, Tenerife, La Gomera, La Palma and El <span class="hlt">Hierro</span>. As with prior studies of oxygen isotopes in Canary Island lavas (e.g. Thirlwall et al. Chem Geol 135:233-262, 1997; Day et al. Geology 37:555-558, 2009, Geochim Cosmochim Acta 74:6565-6589, 2010), these authors find variations in δ18Ool (~4.6-6.0 ‰) beyond that measured for mantle peridotite olivine (Mattey et al. Earth Planet Sci Lett 128:231-241, 1994) and interpret this variation to reflect contributions from pyroxenite-peridotite mantle sources. Furthermore, Gurenko et al. (Contrib Mineral Petrol 162:349-363, 2011) speculate that δ18Ool values for La Palma olivine grains measured by LF (Day et al. Geology 37:555-558, 2009, Geochim Cosmochim Acta 74:6565-6589, 2010) may be biased to low values due to the presence of altered silicate, possibly serpentine. The range in δ18Ool values for Canary Island lavas are of importance for constraining their origin. Gurenko et al. (Contrib Mineral Petrol 162:349-363, 2011) took a subset (39 SIMS analyses from 13 grains from a single El <span class="hlt">Hierro</span> lava; EH4) of a more extensive dataset (321 SIMS analyses from 110 grains from 16 Canary Island lavas) to suggest that δ18Ool is weakly correlated ( R 2 = 0.291) with the parameter used by Gurenko et al. (Earth Planet Sci Lett 277:514-524, 2009) to describe the estimated weight fraction of pyroxenite-derived melt ( Xpx). With this relationship, end-member δ18O values for HIMU-peridotite (δ18O = 5.3 ± 0.3 ‰) and depleted pyroxenite (δ18O = 5.9 ± 0.3 ‰) were defined. Although the model proposed by Gurenko et al. (Contrib Mineral Petrol 162:349-363, 2011) implicates similar pyroxenite-peridotite mantle sources to those proposed by Day et al. (Geology 37:555-558, 2009, Geochim Cosmochim Acta 74:6565-6589, 2010</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27556709','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27556709"><span>Nurses' knowledge to identify early acute kidney injury.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nascimento, Roseli Aparecida Matheus do; Assunção, Murillo Santucci Cesar; Silva, João Manoel; Amendola, Cristina Prata; Carvalho, Taysa Martindo de; Lima, Emerson Quintino; Lobo, Suzana Margareth Ajeje</p> <p>2016-01-01</p> <p>To evaluate the knowledgeof nurses on early identification of acute kidney injury (AKI) in intensive care, emergency and hospitalization units. A prospective multi-center study was conducted with 216 nurses, using a questionnaire with 10 questions related to AKI prevention, diagnosis, and treatment. 57.2% of nurses were unable to identify AKI clinical manifestations, 54.6% did not have knowledge of AKI incidence in patients admitted to the ICU, 87.0% of the nurses did not know how to answer as regards the AKI mortality rate in patients admitted to the ICU, 67.1% answered incorrectly that slight increases in serum creatinine do not have an impact on mortality, 66.8% answered incorrectly to the question on AKI prevention measures, 60.4% answered correctly that loop diuretics for preventing AKI is not recommended, 77.6% answered correctly that AKI does not characterize the need for hemodialysis, and 92.5% said they had no knowledge of the Acute Kidney Injury Networkclassification. Nurses do not have enough knowledge to identify early AKI, demonstrating the importance of qualification programs in this field of knowledge. Avaliar o conhecimento do enfermeiro na identificação precoce da Injúria Renal <span class="hlt">Aguda</span> (IRA) em Unidade de Terapia Intensiva, Unidade de Internação e Emergência. Estudo multicêntrico, prospectivo.Participaram do estudo 216 enfermeiros,<span class="hlt">por</span> meio de questionário com 10 questões relacionadas à prevenção, ao diagnóstico e ao tratamento da IRA. 57,2% não souberam identificar as manifestações clínicas da IRA, 54,6% não têm conhecimento da incidência de IRA em pacientes internados na UTI, 87,0% dos enfermeiros não souberam responder ao índice de mortalidade de IRA em pacientes internados na UTI, 67,1% responderam incorretamente que aumentos discretos da creatinina sérica não têm impacto na mortalidade, 66,8% responderam incorretamente à questão sobre as medidas de prevenção da IRA, 60,4% acertaram quando responderam que não </p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26463170','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26463170"><span>Evaluating <span class="hlt">Por</span> Nuestra Salud: A Feasibility Study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Marshall, Brenda; Gonzales, Gustavo; Kernan, William</p> <p>2016-01-01</p> <p>This feasibility study evaluated the impact of a culturally consistent diabetes educational program, led by a Latino pastor, on Latino community diabetes knowledge levels. Latino adults were recruited from two churches serving Latino populations, one identified as intervention, the other as nonintervention. Both churches received the American Diabetes Association's booklets on diabetes education, "Four Steps to Control Your Diabetes for Life." The intervention group also received weekly reviews of the booklet's information from the church pastor, who was educated about diabetes by a Latino family nurse practitioner. Pre- and postintervention levels of diabetes knowledge were measured using the Diabetes Knowledge Questionnaire. Mean changes in the Diabetes Knowledge Questionnaire (DKQ-24) survey from pretest to posttest indicated a significant increase in knowledge in both groups. Only the grades for the participants from the pastor-led group, however, moved from failure in knowledge to high levels of passing. One hundred percent of intervention group participants reported having read the literature. This pilot study supports the feasibility of a local Latino pastor, as a culturally consistent diabetes educator, to increase Latino parishioner's knowledge of diabetes. © 2015 Society for Public Health Education.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li class="active"><span>15</span></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_15 --> <div id="page_16" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li class="active"><span>16</span></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="301"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25415624','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25415624"><span>Heterologous expression of equine CYP3A94 and investigation of a tunable system to regulate co-expressed NADPH P450 oxidoreductase levels.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dettwiler, Ramona; Schmitz, Andrea L; Plattet, Philippe; Zielinski, Jana; Mevissen, Meike</p> <p>2014-01-01</p> <p>The activity of cytochrome P450 enzymes depends on the enzyme NADPH P450 oxidoreductase (<span class="hlt">POR</span>). The aim of this study was to investigate the activity of the equine CYP3A94 using a system that allows to regulate the <span class="hlt">POR</span> protein levels in mammalian cells. CYP3A94 and the equine <span class="hlt">POR</span> were heterologously expressed in V79 cells. In the system used, the <span class="hlt">POR</span> protein regulation is based on a destabilizing domain (DD) that transfers its instability to a fused protein. The resulting fusion protein is therefore degraded by the ubiquitin-proteasome system (UPS). Addition of "Shield-1" prevents the DD fusion protein from degradation. The change of <span class="hlt">POR</span> levels at different Shield-1 concentrations was demonstrated by cytochrome c reduction, Western immunoblot analysis, and immunocytochemistry. The alteration of CYP3A94 activity was investigated using a substrate (BFC) known to detect CYP3A4 activity. Equine CYP3A94 was demonstrated to be metabolically active and its activity could be significantly elevated by co-expression of <span class="hlt">POR</span>. Cytochrome c reduction was significantly increased in V79-CYP3A94/DD-<span class="hlt">POR</span> cells compared to V79-CYP3A94 cells. Surprisingly, incubation with different Shield-1 concentrations resulted in a decrease in <span class="hlt">POR</span> protein shown by Western immunoblot analysis. Cytochrome c reduction did not change significantly, but the CYP3A94 activity decreased more than 4-fold after incubation with 500 nM and 1 µM Shield-1 for 24 hours. No differences were obtained when V79-CYP3A94 <span class="hlt">POR</span> cells with and without Shield-1 were compared. The basal activity levels of V79-CYP3A94/DD-<span class="hlt">POR</span> cells were unexpectedly high, indicating that DD/<span class="hlt">POR</span> is not degraded without Shield-1. Shield-1 decreased <span class="hlt">POR</span> protein levels and CYP3A94 activity suggesting that Shield-1 might impair <span class="hlt">POR</span> activity by an unknown mechanism. Although regulation of <span class="hlt">POR</span> with the pPTuner system could not be obtained, the cell line V79-CYP3A94/DD-<span class="hlt">POR</span> system can be used for further experiments to characterize the equine CYP3A94</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20531049','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20531049"><span>Primary language and cultural background as factors in resident burnout in medical specialties: a study in a bilingual US city.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Afzal, Khalid I; Khan, Farhan M; Mulla, Zuber; Akins, Ralista; Ledger, Elizabeth; Giordano, Frank L</p> <p>2010-07-01</p> <p>The aim of this study was to identify the degree of burnout among resident physicians enrolled in seven postgraduate training programs at Texas Tech University Health Sciences Center (TTUHSC), Paul L. Foster School of Medicine, El Paso, Texas, as it related to residents' age, gender, marital status, number of hours worked per week, primary language, race/ethnicity, and cultural background. : The Maslach Burnout Inventory Human Service Survey (MBI) was administered to measure the level of burnout according to the prevalence of emotional exhaustion (EE), depersonalization (DP), and reduced personal accomplishment (PA). : Eighty-one percent of the residents at TTUHSC participated in the study. Residents raised in the United States or Canada comprised 28% and 35% of the study, and all reported English as their primary language. The EE scale was significant for obstetrics/gynecology (OB/GYN) residents (prevalence odds ratio [<span class="hlt">POR</span>] = 13.55, P = 0.02) and psychiatry (PSY) residents (<span class="hlt">POR</span> = 6.50, P = 0.03). Emergency medicine (EM) residents (<span class="hlt">POR</span> = 23.35, P = 0.002), OB/GYN (<span class="hlt">POR</span> = 10.89, P = 0.02), and general surgery (GS) (<span class="hlt">POR</span> = 6.24, P = 0.03) residents had high DP. Internal medicine (IM) residents (primarily Spanish-speaking) reported significantly low EE (<span class="hlt">POR</span> = 0.22, P = 0.03) and PA (<span class="hlt">POR</span> = 0.09, P = 0.001) scores. Residents from the United States or Canada who reported English as their primary language and noted their race as white, had high EE (<span class="hlt">POR</span> = 3.06, P = 0.03; <span class="hlt">POR</span> = 5.61, P = 0.0001; <span class="hlt">POR</span> = 2.91, P = 0.004), DP (<span class="hlt">POR</span> = 3.19, P = 0.02; <span class="hlt">POR</span> = 8.34, P < or = 0.0001; <span class="hlt">POR</span> = 4.70, P < or = 0.0001) and PA (<span class="hlt">POR</span> = 2.61, P = 0.02; <span class="hlt">POR</span> = 2.35, P = 0.05, <span class="hlt">POR</span> 0.29, P = 0.3) scores. Using valid measures, this pilot study identified a statistically significant relationship between burnout and residents' race/ethnicity, primary language, and cultural background. Larger studies with similar focus would be necessary to generalize these findings. At-risk residents in bilingual</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22202808-reduction-hepatic-drug-metabolizing-cyp3a4-activities-caused-p450-oxidoreductase-mutations-identified-patients-disordered-steroid-metabolism','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22202808-reduction-hepatic-drug-metabolizing-cyp3a4-activities-caused-p450-oxidoreductase-mutations-identified-patients-disordered-steroid-metabolism"><span>Reduction in hepatic drug metabolizing CYP3A4 activities caused by P450 oxidoreductase mutations identified in patients with disordered steroid metabolism</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Flueck, Christa E.; Mullis, Primus E.; Pandey, Amit V., E-mail: amit@pandeylab.org</p> <p>2010-10-08</p> <p>Research highlights: {yields} Cytochrome P450 3A4 (CYP3A4), metabolizes 50% of drugs in clinical use and requires NADPH-P450 reductase (<span class="hlt">POR</span>). {yields} Mutations in human <span class="hlt">POR</span> cause congenital adrenal hyperplasia from diminished activities of steroid metabolizing P450s. {yields} We are reporting that mutations in <span class="hlt">POR</span> may reduce CYP3A4 activity. {yields} <span class="hlt">POR</span> mutants Y181D, A457H, Y459H, V492E and R616X lost 99%, while A287P, C569Y and V608F lost 60-85% CYP3A4 activity. {yields} Reduction of CYP3A4 activity may cause increased risk of drug toxicities/adverse drug reactions in patients with <span class="hlt">POR</span> mutations. -- Abstract: Cytochrome P450 3A4 (CYP3A4), the major P450 present in human liver metabolizesmore » approximately half the drugs in clinical use and requires electrons supplied from NADPH through NADPH-P450 reductase (<span class="hlt">POR</span>, CPR). Mutations in human <span class="hlt">POR</span> cause a rare form of congenital adrenal hyperplasia from diminished activities of steroid metabolizing P450s. In this study we examined the effect of mutations in <span class="hlt">POR</span> on CYP3A4 activity. We used purified preparations of wild type and mutant human <span class="hlt">POR</span> and in vitro reconstitution with purified CYP3A4 to perform kinetic studies. We are reporting that mutations in <span class="hlt">POR</span> identified in patients with disordered steroidogenesis/Antley-Bixler syndrome (ABS) may reduce CYP3A4 activity, potentially affecting drug metabolism in individuals carrying mutant <span class="hlt">POR</span> alleles. <span class="hlt">POR</span> mutants Y181D, A457H, Y459H, V492E and R616X had more than 99% loss of CYP3A4 activity, while <span class="hlt">POR</span> mutations A287P, C569Y and V608F lost 60-85% activity. Loss of CYP3A4 activity may result in increased risk of drug toxicities and adverse drug reactions in patients with <span class="hlt">POR</span> mutations.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22202779-altered-heme-catabolism-heme-oxygenase-caused-mutations-human-nadph-cytochrome-p450-reductase','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22202779-altered-heme-catabolism-heme-oxygenase-caused-mutations-human-nadph-cytochrome-p450-reductase"><span>Altered heme catabolism by heme oxygenase-1 caused by mutations in human NADPH cytochrome P450 reductase</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Pandey, Amit V., E-mail: amit@pandeylab.org; Flueck, Christa E.; Mullis, Primus E.</p> <p>2010-09-24</p> <p>Research highlights: {yields} Mutations in <span class="hlt">POR</span> identified from patients lead to reduced HO-1 activities. {yields} <span class="hlt">POR</span> mutation Y181D affecting FMN binding results in total loss of HO-1 activity. {yields} <span class="hlt">POR</span> mutations A287P, C569Y and V608F, lost 50-70% activity. {yields} Mutations in FAD binding domain, R457H, Y459H and V492E lost all HO-1 activity. {yields} <span class="hlt">POR</span> polymorphisms P228L, R316W, G413S, A503V and G504R have normal activity. -- Abstract: Human heme oxygenase-1 (HO-1) carries out heme catabolism supported by electrons supplied from the NADPH through NADPH P450 reductase (<span class="hlt">POR</span>, CPR). Previously we have shown that mutations in human <span class="hlt">POR</span> cause a rare formmore » of congenital adrenal hyperplasia. In this study, we have evaluated the effects of mutations in <span class="hlt">POR</span> on HO-1 activity. We used purified preparations of wild type and mutant human <span class="hlt">POR</span> and in vitro reconstitution with purified HO-1 to measure heme degradation in a coupled assay using biliverdin reductase. Here we show that mutations in <span class="hlt">POR</span> found in patients may reduce HO-1 activity, potentially influencing heme catabolism in individuals carrying mutant <span class="hlt">POR</span> alleles. <span class="hlt">POR</span> mutants Y181D, A457H, Y459H, V492E and R616X had total loss of HO-1 activity, while <span class="hlt">POR</span> mutations A287P, C569Y and V608F lost 50-70% activity. The <span class="hlt">POR</span> variants P228L, R316W and G413S, A503V and G504R identified as polymorphs had close to WT activity. Loss of HO-1 activity may result in increased oxidative neurotoxicity, anemia, growth retardation and iron deposition. Further examination of patients affected with <span class="hlt">POR</span> deficiency will be required to assess the metabolic effects of reduced HO-1 activity in affected individuals.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4240602','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4240602"><span>Heterologous Expression of Equine CYP3A94 and Investigation of a Tunable System to Regulate Co-Expressed NADPH P450 Oxidoreductase Levels</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Dettwiler, Ramona; Schmitz, Andrea L.; Plattet, Philippe; Zielinski, Jana; Mevissen, Meike</p> <p>2014-01-01</p> <p>The activity of cytochrome P450 enzymes depends on the enzyme NADPH P450 oxidoreductase (<span class="hlt">POR</span>). The aim of this study was to investigate the activity of the equine CYP3A94 using a system that allows to regulate the <span class="hlt">POR</span> protein levels in mammalian cells. CYP3A94 and the equine <span class="hlt">POR</span> were heterologously expressed in V79 cells. In the system used, the <span class="hlt">POR</span> protein regulation is based on a destabilizing domain (DD) that transfers its instability to a fused protein. The resulting fusion protein is therefore degraded by the ubiquitin-proteasome system (UPS). Addition of “Shield-1” prevents the DD fusion protein from degradation. The change of <span class="hlt">POR</span> levels at different Shield-1 concentrations was demonstrated by cytochrome c reduction, Western immunoblot analysis, and immunocytochemistry. The alteration of CYP3A94 activity was investigated using a substrate (BFC) known to detect CYP3A4 activity. Equine CYP3A94 was demonstrated to be metabolically active and its activity could be significantly elevated by co-expression of <span class="hlt">POR</span>. Cytochrome c reduction was significantly increased in V79-CYP3A94/DD-<span class="hlt">POR</span> cells compared to V79-CYP3A94 cells. Surprisingly, incubation with different Shield-1 concentrations resulted in a decrease in <span class="hlt">POR</span> protein shown by Western immunoblot analysis. Cytochrome c reduction did not change significantly, but the CYP3A94 activity decreased more than 4-fold after incubation with 500 nM and 1 µM Shield-1 for 24 hours. No differences were obtained when V79-CYP3A94 <span class="hlt">POR</span> cells with and without Shield-1 were compared. The basal activity levels of V79-CYP3A94/DD-<span class="hlt">POR</span> cells were unexpectedly high, indicating that DD/<span class="hlt">POR</span> is not degraded without Shield-1. Shield-1 decreased <span class="hlt">POR</span> protein levels and CYP3A94 activity suggesting that Shield-1 might impair <span class="hlt">POR</span> activity by an unknown mechanism. Although regulation of <span class="hlt">POR</span> with the pPTuner system could not be obtained, the cell line V79-CYP3A94/DD-<span class="hlt">POR</span> system can be used for further experiments to characterize the equine CYP3A</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015SGeo...36..513R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015SGeo...36..513R"><span>Evaluating Topographic Effects on Ground Deformation: Insights from Finite Element Modeling</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ronchin, Erika; Geyer, Adelina; Martí, Joan</p> <p>2015-07-01</p> <p>Ground deformation has been demonstrated to be one of the most common signals of volcanic unrest. Although volcanoes are commonly associated with significant topographic relief, most analytical models assume the Earth's surface as flat. However, it has been confirmed that this approximation can lead to important misinterpretations of the recorded surface deformation data. Here we perform a systematic and quantitative analysis of how topography may influence ground deformation signals generated by a spherical pressure source embedded in an elastic homogeneous media and how these variations correlate with the different topographic parameters characterizing the terrain form (e.g., slope, aspect, curvature). For this, we bring together the results presented in previous published papers and complement them with new axisymmetric and 3D finite element (FE) model results. First, we study, in a parametric way, the influence of a volcanic edifice centered above the pressure source axis. Second, we carry out new 3D FE models simulating the real topography of three different volcanic areas representative of topographic scenarios common in volcanic regions: Rabaul caldera (Papua New Guinea) and the volcanic islands of Tenerife and El <span class="hlt">Hierro</span> (Canary Islands). The calculated differences are then correlated with a series of topographic parameters. The final aim is to investigate the artifacts that might arise from the use of half-space models at volcanic areas due to diverse topographic features (e.g., collapse caldera structures, prominent central edifices, large landslide scars).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016ECSS..178...48S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016ECSS..178...48S"><span>Seaweed community response to a massive CO2 input</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Sangil, Carlos; Clemente, Sabrina; Brito, Alberto; Rodríguez, Adriana; Balsalobre, Marc; Mendoza, José Carlos; Martínez, David; Hernández, José Carlos</p> <p>2016-09-01</p> <p>Changes in the structure of seaweed communities were examined following a massive CO2 input caused by a submarine eruption near the coast of El <span class="hlt">Hierro</span> island (Canary Islands, Spain). The event lasted almost five months (October 2011-March 2012) and created a significant pH gradient. Specifically, we compared three different zones: highly affected with extreme low pH (6.7-7.3), affected with low pH (7.6-7.8), and unaffected ambient pH zone (∼8.1) according to the pH gradient generated by the predominate currents and waves in the south of the island. Studies were carried out before, during and after the CO2 input event in each zone. We found community-wide effects on seaweed communities during the eruption; these included changes in species abundance and changes in the diversity. However, changes in all these community traits were only evident in the highly affected zone, where there were major shifts in the seaweed community, with a replacement of Lobophora variegata by ephemeral seaweeds. Lobophora variegata dropped in cover from 87-94 to 27% while ephemeral seaweeds increased 6-10 to 29%. When the impact ended Lobophora variegata began to recover reaching a cover higher than 60%. In the moderate affected area the Lobophora variegata canopies maintained their integrity avoiding phase shifts to turfs. Here the only significant changes were the reduction of the cover of the crustose and geniculate coralline algae.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16839782','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16839782"><span>Molecular evidence for adaptive radiation of Micromeria Benth. (Lamiaceae) on the Canary Islands as inferred from chloroplast and nuclear DNA sequences and ISSR fingerprint data.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Meimberg, Harald; Abele, Tilmann; Bräuchler, Christian; McKay, John K; Pérez de Paz, Pedro L; Heubl, Günther</p> <p>2006-12-01</p> <p>The Canary Islands have been a focus for phylogeographic studies on the colonization and diversification of endemic angiosperm taxa. Based on phylogeographic patterns, both inter island colonization and adaptive radiation seem to be the driving forces for speciation in most taxa. Here, we investigated the diversification of Micromeria on the Canary Islands and Madeira at the inter- and infraspecific level using inter simple sequence repeat PCR (ISSR), the trnK-Intron and the trnT-trnL-spacer of the cpDNA and a low copy nuclear gene. The genus Micromeria (Lamiaceae, Mentheae) includes 16 species and 13 subspecies in Macaronesia. Most taxa are restricted endemics, or grow in similar ecological conditions on two islands. An exception is M. varia, a widespread species inhabits the lowland scrub on each island of the archipelago and could represent an ancestral taxon from which radiation started on the different islands. Our analyses support a split between the "eastern" islands Fuerteventura, Lanzarote and Gran Canaria and the "western" islands Tenerife, La Palma and El <span class="hlt">Hierro</span>. The colonization of Madeira started from the western Islands, probably from Tenerife as indicated by the sequence data. We identified two lineages of Micromeria on Gomera but all other islands appear to be colonized by a single lineage, supporting adaptive radiation as the major evolutionary force for the diversification of Micromeria. We also discuss the possible role of gene flow between lineages of different Micromeria species on one island after multiple colonizations.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFM.S34B..06G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFM.S34B..06G"><span>Multiscale spatial and temporal estimation of the b-value</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>García-Hernández, R.; D'Auria, L.; Barrancos, J.; Padilla, G.</p> <p>2017-12-01</p> <p>The estimation of the spatial and temporal variations of the Gutenberg-Richter b-value is of great importance in different seismological applications. One of the problems affecting its estimation is the heterogeneous distribution of the seismicity which makes its estimate strongly dependent upon the selected spatial and/or temporal scale. This is especially important in volcanoes where dense clusters of earthquakes often overlap the background seismicity. Proposed solutions for estimating temporal variations of the b-value include considering equally spaced time intervals or variable intervals having an equal number of earthquakes. Similar approaches have been proposed to image the spatial variations of this parameter as well.We propose a novel multiscale approach, based on the method of Ogata and Katsura (1993), allowing a consistent estimation of the b-value regardless of the considered spatial and/or temporal scales. Our method, named MUST-B (MUltiscale Spatial and Temporal characterization of the B-value), basically consists in computing estimates of the b-value at multiple temporal and spatial scales, extracting for a give spatio-temporal point a statistical estimator of the value, as well as and indication of the characteristic spatio-temporal scale. This approach includes also a consistent estimation of the completeness magnitude (Mc) and of the uncertainties over both b and Mc.We applied this method to example datasets for volcanic (Tenerife, El <span class="hlt">Hierro</span>) and tectonic areas (Central Italy) as well as an example application at global scale.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28755716','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28755716"><span>"Canary Islands (NE Atlantic) as a biodiversity 'hotspot' of Gambierdiscus: Implications for future trends of ciguatera in the area".</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rodríguez, Francisco; Fraga, Santiago; Ramilo, Isabel; Rial, Pilar; Figueroa, Rosa Isabel; Riobó, Pilar; Bravo, Isabel</p> <p>2017-07-01</p> <p>In the present study the geographical distribution, abundance and composition of Gambierdiscus was described over a 600km longitudinal scale in the Canary Islands. Samples for cell counts, isolation and identification of Gambierdiscus were obtained from five islands (El <span class="hlt">Hierro</span>, Tenerife, Gran Canaria, Fuerteventura and Lanzarote). Average densities of Gambierdiscus spp. between 0 and 2200cellsg -1 blot dry weight of macrophyte were recorded. Morphological (light microscopy and SEM techniques) and molecular analyses (LSU and SSU rDNA sequencing of cultures and single cells from the field) of Gambierdiscus was performed. Five Gambierdiscus species (G. australes, G. caribaeus, G. carolinianus, G. excentricus and G. silvae), together with a new putative species (Gambierdiscus ribotype 3) were identified. These results suggest that some cases of CFP in the region could be associated with the accumulation of ciguatoxins in the marine food web acquired from local populations of Gambierdiscus. This unexpected high diversity of Gambierdiscus species in an area which a priori is not under risk of ciguatera, hints at an ancient settlement of Gambierdiscus populations, likely favored by warmer climate conditions in the Miocene Epoch (when oldest current Canary Islands were created), in contrast with cooler present ones. Currently, warming trends associated with climate change could contribute to extend favorable environmental conditions in the area for Gambierdiscus growth especially during winter months. Copyright © 2017 The Author(s). Published by Elsevier B.V. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23092891','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23092891"><span>P450 oxidoreductase deficiency: a disorder of steroidogenesis with multiple clinical manifestations.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Miller, Walter L</p> <p>2012-10-23</p> <p>Cytochrome P450 enzymes catalyze the biosynthesis of steroid hormones and metabolize drugs. There are seven human type I P450 enzymes in mitochondria and 50 type II enzymes in endoplasmic reticulum. Type II enzymes, including both drug-metabolizing and some steroidogenic enzymes, require electron donation from a two-flavin protein, P450 oxidoreductase (<span class="hlt">POR</span>). Although knockout of the <span class="hlt">POR</span> gene causes embryonic lethality in mice, we discovered human <span class="hlt">POR</span> deficiency as a disorder of steroidogenesis associated with the Antley-Bixler skeletal malformation syndrome and found mild <span class="hlt">POR</span> mutations in phenotypically normal adults with infertility. Assay results of mutant forms of <span class="hlt">POR</span> using the traditional but nonphysiologic assay (reduction of cytochrome c) did not correlate with patient phenotypes; assays based on the 17,20 lyase activity of P450c17 (CYP17) correlated with clinical phenotypes. The <span class="hlt">POR</span> sequence in 842 normal individuals revealed many polymorphisms; amino acid sequence variant A503V is encoded by ~28% of human alleles. <span class="hlt">POR</span> A503V has about 60% of wild-type activity in assays with CYP17, CYP2D6, and CYP3A4, but nearly wild-type activity with P450c21, CYP1A2, and CYP2C19. Activity of a particular <span class="hlt">POR</span> variant with one P450 enzyme will not predict its activity with another P450 enzyme: Each <span class="hlt">POR</span>-P450 combination must be studied individually. Human <span class="hlt">POR</span> transcription, initiated from an untranslated exon, is regulated by Smad3/4, thyroid receptors, and the transcription factor AP-2. A promoter polymorphism reduces transcription to 60% in liver cells and to 35% in adrenal cells. <span class="hlt">POR</span> deficiency is a newly described disorder of steroidogenesis, and <span class="hlt">POR</span> variants may account for some genetic variation in drug metabolism.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70036418','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70036418"><span>Patterns of coral disease across the Hawaiian Archipelago: Relating disease to environment</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Aeby, G.S.; Williams, G.J.; Franklin, E.C.; Kenyon, J.; Cox, E.F.; Coles, S.; Work, Thierry M.</p> <p>2011-01-01</p> <p>In Hawaii, coral reefs occur across a gradient of biological (host abundance), climatic (sea surface temperature anomalies) and anthropogenic conditions from the human-impacted reefs of the main Hawaiian Islands (MHI) to the pristine reefs of the northwestern Hawaiian Islands (NWHI). Coral disease surveys were conducted at 142 sites from across the Archipelago and disease patterns examined. Twelve diseases were recorded from three coral genera (Porites, Montipora, Acropora) with Porites having the highest prevalence. Porites growth anomalies (<span class="hlt">Por</span>GAs) were significantly more prevalent within and indicative of reefs in the MHI and Porites trematodiasis (<span class="hlt">Por</span>Trm) was significantly more prevalent within and indicative of reefs in the NWHI. Porites tissue loss syndrome (<span class="hlt">Por</span>TLS) was also important in driving regional differences but that relationship was less clear. These results highlight the importance of understanding disease ecology when interpreting patterns of disease occurrence. <span class="hlt">Por</span>Trm is caused by a parasitic flatworm that utilizes multiple hosts during its life cycle (fish, mollusk and coral). All three hosts must be present for the disease to occur and higher host abundance leads to higher disease prevalence. Thus, a high prevalence of <span class="hlt">Por</span>Trm on Hawaiian reefs would be an indicator of a healthy coral reef ecosystem. In contrast, the high occurrence of <span class="hlt">Por</span>GAs within the MHI suggests that <span class="hlt">Por</span>GAs are related, directly or indirectly, to some environmental co-factor associated with increased human population sizes. Focusing on the three indicator diseases (<span class="hlt">Por</span>GAs, <span class="hlt">Por</span>Trm, <span class="hlt">Por</span>TLS) we used statistical modeling to examine the underlying associations between disease prevalence and 14 different predictor variables (biotic and abiotic). All three diseases showed positive associations with host abundance and negative associations with thermal stress. The association with human population density differed among disease states with <span class="hlt">Por</span>GAs showing a positive and <span class="hlt">Por</span>Trm showing</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3105043','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3105043"><span>Patterns of Coral Disease across the Hawaiian Archipelago: Relating Disease to Environment</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Aeby, Greta S.; Williams, Gareth J.; Franklin, Erik C.; Kenyon, Jean; Cox, Evelyn F.; Coles, Steve; Work, Thierry M.</p> <p>2011-01-01</p> <p>In Hawaii, coral reefs occur across a gradient of biological (host abundance), climatic (sea surface temperature anomalies) and anthropogenic conditions from the human-impacted reefs of the main Hawaiian Islands (MHI) to the pristine reefs of the northwestern Hawaiian Islands (NWHI). Coral disease surveys were conducted at 142 sites from across the Archipelago and disease patterns examined. Twelve diseases were recorded from three coral genera (Porites, Montipora, Acropora) with Porites having the highest prevalence. Porites growth anomalies (<span class="hlt">Por</span>GAs) were significantly more prevalent within and indicative of reefs in the MHI and Porites trematodiasis (<span class="hlt">Por</span>Trm) was significantly more prevalent within and indicative of reefs in the NWHI. Porites tissue loss syndrome (<span class="hlt">Por</span>TLS) was also important in driving regional differences but that relationship was less clear. These results highlight the importance of understanding disease ecology when interpreting patterns of disease occurrence. <span class="hlt">Por</span>Trm is caused by a parasitic flatworm that utilizes multiple hosts during its life cycle (fish, mollusk and coral). All three hosts must be present for the disease to occur and higher host abundance leads to higher disease prevalence. Thus, a high prevalence of <span class="hlt">Por</span>Trm on Hawaiian reefs would be an indicator of a healthy coral reef ecosystem. In contrast, the high occurrence of <span class="hlt">Por</span>GAs within the MHI suggests that <span class="hlt">Por</span>GAs are related, directly or indirectly, to some environmental co-factor associated with increased human population sizes. Focusing on the three indicator diseases (<span class="hlt">Por</span>GAs, <span class="hlt">Por</span>Trm, <span class="hlt">Por</span>TLS) we used statistical modeling to examine the underlying associations between disease prevalence and 14 different predictor variables (biotic and abiotic). All three diseases showed positive associations with host abundance and negative associations with thermal stress. The association with human population density differed among disease states with <span class="hlt">Por</span>GAs showing a positive and <span class="hlt">Por</span>Trm showing</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19453773','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19453773"><span>Evaluation of six nucleic acid amplification tests used for diagnosis of Neisseria gonorrhoeae in Russia compared with an international strictly validated real-time <span class="hlt">por</span>A pseudogene polymerase chain reaction.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Shipitsyna, E; Zolotoverkhaya, E; Hjelmevoll, S O; Maximova, A; Savicheva, A; Sokolovsky, E; Skogen, V; Domeika, M; Unemo, M</p> <p>2009-11-01</p> <p>In Russia, laboratory diagnosis of gonorrhoea has been mainly based on microscopy only and, in some settings, relatively rare suboptimal culturing. In recent years, Russian developed and manufactured nucleic acid amplification tests (NAAT) have been implemented for routine diagnosis of Neisseria gonorrhoeae. However, these NAATs have never been validated to any international well-recognized diagnostic NAAT. This study aims to evaluate the performance characteristics of six Russian NAATs for N. gonorrhoeae diagnostics. In total, 496 symptomatic patients were included. Five polymerase chain reaction (PCR) assays and one real-time nucleic acid sequence based amplification (NASBA) assay, developed by three Russian companies, were evaluated on urogenital samples, i.e. cervical and first voided urine (FVU) samples from females (n = 319), urethral and FVU samples from males (n = 127), and extragenital samples, i.e. rectal and pharyngeal samples, from 50 additional female patients with suspicion of gonorrhoea. As reference method, an international strictly validated real-time <span class="hlt">por</span>A pseudogene PCR was applied. The prevalence of N. gonorrhoeae was 2.7% and 16% among the patients providing urogenital and extragenital samples, respectively. The Russian NAATs and the reference method displayed high level of concordance (99.4-100%). The sensitivities, specificities, positive predictive values and negative predictive values of the Russian tests in different specimens were 66.7-100%, 100%, 100%, and 99.4-100%, respectively. Russian N. gonorrhoeae diagnostic NAATs comprise relatively good performance characteristics. However, larger studies are crucial and, beneficially, the Russian assays should also be evaluated to other international highly sensitive and specific, and ideally Food and Drug Administration approved, NAATs such as Aptima Combo 2 (Gen-Probe).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27762457','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27762457"><span>Longitudinal hemodynamics in acute phase of treatment with labetalol in hypertensive pregnant women to predict need for vasodilatory therapy.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stott, D; Bolten, M; Paraschiv, D; Papastefanou, I; Chambers, J B; Kametas, N A</p> <p>2017-01-01</p> <p> decrease at 1 h and 24 h. Stroke volume and CO did not decrease during the acute phase of treatment in either group. The best model for prediction of the need for vasodilators was provided at 24 h by combining ethnicity and longitudinal BP and heart rate changes. The model achieved a detection rate of 100% for a false-positive rate of 20% and an area under the receiver-operating characteristics curve of 0.97. Maternal demographics and hemodynamic changes in the acute phase of labetalol monotherapy provide a powerful tool to identify hypertensive pregnant patients who are unlikely to have their BP controlled by this therapy and will consequently need additional vasodilatory therapy. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd. Las embarazadas hipertensas que no responden al tratamiento con labetalol para el control de la presión arterial (PA), pero que requieren terapia vasodilatadora, evolucionan rápidamente hacia una hipertensión severa. Ésta se puede retrasar mediante un diagnóstico precoz y un tratamiento individual. En este estudio se ha tratado de crear modelos de predicción a partir de datos al inicio del tratamiento y al cabo de 1 hora y de 24 horas después del mismo, para identificar a las pacientes que no mostrarán una respuesta constante al labetalol y que <span class="hlt">por</span> lo tanto necesitarán terapia vasodilatadora. MÉTODOS: La población de estudio incluyó 134 mujeres con hipertensión en un hospital del Reino Unido. El tratamiento con labetalol <span class="hlt">por</span> vía oral se administró cuando la PA fue >150/100 mm de Hg o >140/90 mm de Hg con enfermedad multisistémica. Se registró la PA y los parámetros hemodinámicos tanto al inicio como al cabo de 1 h y de 24 h después del inicio del tratamiento. Las dosis de Labetalol se ajustaron para mantener la PA en torno a los 135/85 mm de Hg. Las mujeres cuya PA no produjo respuesta, a pesar de haberles administrado la dosis máxima de labetalol (2400 mg/día), recibieron terapia vasodilatadora adicional con</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3484016','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3484016"><span>Medicinal ethnobotany in Huacareta (Chuquisaca, Bolivia)</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2012-01-01</p> <p> used as a base for subsequent work related to traditional medicine and its contribution to allopathic medicine in San Pablo de Huacareta. Resumen Introducción El objetivo del presente estudio fue documentar los tipos de enfermedades tratadas mediante el uso de plantas medicinales, sus aplicaciones principales y también tener un reporte de las enfermedades mayormente atendidas en el Hospital de San Pablo de Huacareta (Chuquisaca, Bolivia). Métodos Se realizaron encuestas semiestructuradas a 10 informantes locales anotando los usos atribuidos a sus plantas medicinales, se agruparon las plantas <span class="hlt">por</span> categorías de enfermedades tratadas en la medicina tradicional. Se obtuvieron reportes de casos tratados en el Hospital de Huacareta para poder relacionar el tratamiento de enfermedades recurrentes en la zona entre la medicina tradicional y la medicina occidental. Resultados Se reportaron 91 especies nativas y exóticas, además de un espécimen indeterminado exótico que intervienen en un total de 258 aplicaciones medicinales, las cuales son empleadas en un total de 13 categorías de enfermedades. Los desórdenes gastrointestinales (55%) son mayormente tratados mediante plantas medicinales, seguidas de las afecciones al sistema esqueleto-muscular (25%) y enfermedades dermatológicas (24%). La información del Hospital indica que las enfermedades más frecuentes son Infecciones Respiratorias <span class="hlt">Agudas</span> (47%) y Enfermedades Diarreicas <span class="hlt">Agudas</span> (37%). Los remedios vegetales se emplean en forma de infusiones y cocciones principalmente. Se emplean mayormente plantas nativas, también se introdujo en la farmacopea médica el uso de plantas exóticas al lugar. Conclusiones El tratamiento de trastornos gastrointestinales constituye el objetivo primordial de la etnobotánica médica de los habitantes de Huacareta, las enfermedades del sistema respiratorio, son mayormente tratadas en el Hospital. Observando los datos del libro de consultas del Hospital, se puede inferir que los des</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.fs.usda.gov/treesearch/pubs/10856','TREESEARCH'); return false;" href="https://www.fs.usda.gov/treesearch/pubs/10856"><span>Alerta De Insecto-Escarabajo asiatico de antenoas largas</span></a></p> <p><a target="_blank" href="http://www.fs.usda.gov/treesearch/">Treesearch</a></p> <p>Marco A. Fonseca; Ronald F. Billings</p> <p></p> <p>Hay probablemente una sola generacion de ALB <span class="hlt">por</span> a'o. Los escarabajos adultos <span class="hlt">por</span> lo general estan presentes de mayo a octubre, pero se pueden encontrar mas temprano en la primavera o mas tarde en el oto?o si las temperaturas son calidas. Los adultos <span class="hlt">por</span> lo general permanecen en el arbol del que emergieron o se pueden desplazar <span class="hlt">por</span> distancias cortas hacia un...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29902172','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29902172"><span>Geographical variation of overweight, obesity and related risk factors: Findings from the European Health Examination Survey in Luxembourg, 2013-2015.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Samouda, Hanen; Ruiz-Castell, Maria; Bocquet, Valery; Kuemmerle, Andrea; Chioti, Anna; Dadoun, Frédéric; Kandala, Ngianga-Bakwin; Stranges, Saverio</p> <p>2018-01-01</p> <p>The analyses of geographic variations in the prevalence of major chronic conditions, such as overweight and obesity, are an important public health tool to identify "hot spots" and inform allocation of funding for policy and health promotion campaigns, yet rarely performed. Here we aimed at exploring, for the first time in Luxembourg, potential geographic patterns in overweight/obesity prevalence in the country, adjusted for several demographic, socioeconomic, behavioural and health status characteristics. Data came from 720 men and 764 women, 25-64 years old, who participated in the European Health Examination Survey in Luxembourg (2013-2015). To investigate the geographical variation, geo-additive semi-parametric mixed model and Bayesian modelisations based on Markov Chain Monte Carlo techniques for inference were performed. Large disparities in the prevalence of overweight and obesity were found between municipalities, with the highest rates of obesity found in 3 municipalities located in the South-West of the country. Bayesian approach also underlined a nonlinear effect of age on overweight and obesity in both genders (significant in men) and highlighted the following risk factors: 1. country of birth for overweight in men born in a non-European country (Posterior Odds Ratio (<span class="hlt">POR</span>): 3.24 [1.61-8.69]) and women born in Portugal (<span class="hlt">POR</span>: 2.44 [1.25-4.43]), 2. low educational level (secondary or below) for overweight (<span class="hlt">POR</span>: 1.66 (1.06-2.72)] and obesity (<span class="hlt">POR</span>:2.09 [1.05-3.65]) in men, 3. single marital status for obesity in women (<span class="hlt">POR</span>: 2.20 [1.24-3.91]), 4.fair (men: <span class="hlt">POR</span>: 3.19 [1.58-6.79], women: <span class="hlt">POR</span>: 2.24 [1.33-3.73]) to very bad health perception (men: <span class="hlt">POR</span>: 15.01 [2.16-98.09]) for obesity, 5. sleeping more than 6 hours for obesity in unemployed men (<span class="hlt">POR</span>: 3.66 [2.02-8.03]). Protective factors highlighted were: 1. single marital status against overweight (<span class="hlt">POR</span>: [0.60 (0.38-0.96)]) and obesity (<span class="hlt">POR</span>: 0.39 [0.16-0.84]) in men, 2. the fact to be widowed against overweight in</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011RELEA..11....7I','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011RELEA..11....7I"><span>The Understanding of Astronomy Concepts by Students from Basic Education of a Public School. (Spanish Title: El Entendimiento de Conceptos de Aastronmía <span class="hlt">Por</span> Los Alumnos de Educación Básica en Una Escuela Pública.) O Entendimento de Conceitos de Astronomia <span class="hlt">Por</span> Alunos da Educação Básica: O Caso de Uma Escola Pública Brasileira</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Iria Machado, Daniel; dos Santos, Carlos</p> <p>2011-07-01</p> <p>We present the results obtained in a research on the comprehension of basic astronomical concepts, in which 561 students from fifth grade middle school to third grade high school of a public school of the city of Foz do Iguaçu (Brazil) took part. A test with 20 multiple-choice questions was applied to indentify the most common conceptions expressed by the students. This test was elaborated based on the literature about misconceptions and covered the following topics: the day-night cycle; the time zones; the seasons of the year; the phases of the Moon; the movement of the Moon; the apparent movement of the Sun in the celestial sphere; the eclipses; the dimensions and distances in the Universe; the brightness of the stars and its observation from Earth. Though a small progress was verified in the proportion of scientifically acceptable answers when comparing the eighth grade of middle school to the fifth, and the third grade of high school to the first, there was an overall predominance of alternative conceptions regarding most of the explored subjects, which persisted up to the last year of secondary school. The comparison to data found in this research made in other socio-cultural contexts revealed, in many aspects, similar notions and difficulties revealed by the students. Se presentan los resultados de una investigación sobre la comprensión de conceptos astronómicos básicos, en la cual participaron 561 estudiantes que cursaban entre el quinto grado de la enseñanza primaria y el tercer año de la enseñanza secundaria de una escuela pública de la ciudad de Foz do Iguaçu (Brasil). Se utilizó un test de 20 preguntas de opción múltiple para identificar las concepciones más comunes expresadas <span class="hlt">por</span> los estudiantes. Este instrumento de recolección de datos se desarrolló en base a la literatura sobre las concepciones alternativas y trató los siguientes temas: el ciclo día-noche, los husos horarios, las estaciones del año, las fases de la Luna, el</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4561608','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4561608"><span>Eficacia de la detección sistemática de la gripe en las fronteras en los viajeros que llegan <span class="hlt">por</span> vía aérea*</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Priest, Patricia C.; Jennings, Lance C.; Duncan, Alasdair R.; Brunton, Cheryl R.; Baker, Michael G.</p> <p>2015-01-01</p> <p>Objetivos. Se midieron los síntomas y la prevalencia de la gripe (también llamada influenza), así como la eficacia del mecanismo de detección sistemática basado en los síntomas y la temperatura para diagnosticar la gripe en viajeros internacionales que llegaban <span class="hlt">por</span> vía aérea. Métodos. El presente estudio transversal recopiló datos de viajeros que llegaron al aeropuerto internacional de Christchurch (Nueva Zelandia) en el invierno del 2008 mediante un cuestionario de salud, medición de la temperatura y toma de muestras de las vías respiratorias. Resultados. De los viajeros, 15 976 (68%) entregaron los formularios completos. De ellos, 17% notificaron al menos un síntoma de gripe; los síntomas más comunes fueron rinorrea o congestión nasal (10%) y tos (8%). Se tomaron muestras de las vías respiratorias de 3 769 viajeros. La prevalencia estimada de la gripe fue de 1,1% (4% en las personas sintomáticas, 0,2% en las asintomáticas). La sensibilidad de los criterios de detección varió de 84% para “cualquier síntoma” a 3% para la fiebre de 37,8 °C o mayor. El valor predictivo positivo fue bajo para todos los criterios. Conclusiones. El método de detección sistemática en las fronteras mediante la autonotificación de síntomas y la toma de la temperatura presenta limitaciones para impedir que una gripe pandémica entre en un país. Basarse en criterios como “cualquier síntoma” o la tos haría que se investigara a varias personas no infectadas, mientras que algunas personas infectadas pasarían inadvertidas. Si se usaran criterios más específicos como la fiebre, la mayoría de las personas infectadas entrarían en el país a pesar del mecanismo de detección.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li class="active"><span>16</span></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_16 --> <div id="page_17" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active"><span>17</span></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="321"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25252137','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25252137"><span>Risk factors associated with human Rift Valley fever infection: systematic review and meta-analysis.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nicholas, Dennis E; Jacobsen, Kathryn H; Waters, Nigel M</p> <p>2014-12-01</p> <p>To identify risk factors for human Rift Valley fever virus (RVFV) infection. A systematic review identified 17 articles reporting on 16 studies examining risk factors for RVFV. Pooled odds ratios (<span class="hlt">pOR</span>) were calculated for exposures examined in four or more studies. Being male [<span class="hlt">pOR</span> = 1.4 (1.0, 1.8)], contact with aborted animal tissue [<span class="hlt">pOR</span> = 3.4 (1.6, 7.3)], birthing an animal [<span class="hlt">pOR</span> = 3.2 (2.4, 4.2)], skinning an animal [<span class="hlt">pOR</span> = 2.5 (1.9, 3.2)], slaughtering an animal [<span class="hlt">pOR</span> = 2.4 (1.4, 4.1)] and drinking raw milk [<span class="hlt">pOR</span> = 1.8 (1.2, 2.6)] were significantly associated with RVF infection after meta-analysis. Other potential risk factors include sheltering animals in the home and milking an animal, which may both involve contact with animal body fluids. Based on the identified risk factors, use of personal protective equipment and disinfectants by animal handlers may help reduce RVFV transmission during outbreaks. Milk pasteurisation and other possible preventive methods require further investigation. © 2014 John Wiley & Sons Ltd.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2443683','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2443683"><span>Camina <span class="hlt">por</span> Salud: Walking in Mexican-American Women</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Keller, Colleen S.; Gonzales, Adelita</p> <p>2008-01-01</p> <p>Forty-six percent of older Mexican-American women report no leisure time physical activity (PA); 38.1% are obese. This study (1) evaluated a PA intervention on reduction of risk for coronary heart disease (CHD) and (2) determined which variables affected adherence to PA. For 36 weeks, Group I walked 3 days/week; Group II walked 5 days/week. The investigators measured total body fat, regional fat, blood lipids, and adherence to PA The walking interventions favorably affected body fat, with significant differences in body mass index (BMI) reductions[F (2, 16) = 12.86, p = .001]. No statistical differences were noted in the anthropometric and blood lipid results from baseline to the 36-week measures. PMID:18457751</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29414974','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29414974"><span>Desigualdad social y tendencias de mortalidad <span class="hlt">por</span> diabetes.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Medina-Gómez, Oswaldo; Medina-Reyes, E Ismael Seth</p> <p>2017-01-01</p> <p>To identify the trend of national diabetes mortality by level of marginality at the state and municipal levels. A descriptive study was conducted with records of deaths from diabetes in over 20 years from 1990 to 2013. The national mortality rate was calculated standardized by age according to the 2000 world population and the state level 2013 saw the projected naational population by join point analysis for trend analysis was performed. For the general population, the annual percentage change between 1990 and 1996 was 2.2, from 1996 to 2005 was 4.3, and from 2005 to 2013 was 0.1. The largest increase among women occurred between 1998 and 2005 while among men occurred between 1995 and 2006. At the state level was found higher annual percentage change between the towns with the highest degree of marginalization. The mortality of diabetes in women shows a significant decrease since 2004, among men, the mortality with a continuous upward trend, consistent with the trend that the disease has had in recent years. Copyright: © 2017 SecretarÍa de Salud</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25099408','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25099408"><span>Disaster-related exposures and health effects among US Coast Guard responders to Hurricanes Katrina and Rita: a cross-sectional study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rusiecki, Jennifer A; Thomas, Dana L; Chen, Ligong; Funk, Renée; McKibben, Jodi; Dayton, Melburn R</p> <p>2014-08-01</p> <p>Disaster responders work among poorly characterized physical and psychological hazards with little understood regarding health consequences of their work. A survey administered to 2834 US Coast Guard responders to Hurricanes Katrina and Rita provided data on exposures and health effects. Prevalence odds ratios (<span class="hlt">PORs</span>) evaluated associations between baseline characteristics, missions, exposures, and health effects. Most frequent exposures were animal/insect vector (n = 1309; 46%) and floodwater (n = 817; 29%). Most frequent health effects were sunburn (n = 1119; 39%) and heat stress (n = 810; 30%). Significant positive associations were for mold exposure and sinus infection (<span class="hlt">POR</span> = 10.39); carbon monoxide and confusion (<span class="hlt">POR</span> = 6.27); lack of sleep and slips, trips, falls (<span class="hlt">POR</span> = 3.34) and depression (<span class="hlt">POR</span> = 3.01); being a Gulf-state responder and depression (<span class="hlt">POR</span> = 3.22). Increasing protection for disaster responders requires provisions for adequate sleep, personal protective equipment, and access to medical and psychological support.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26753183','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26753183"><span>Making the invisible visible: improved electrospray ion formation of metalloporphyrins/-phthalocyanines by attachment of the formate anion (HCOO(-)).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hitzenberger, Jakob Felix; Dammann, Claudia; Lang, Nina; Lungerich, Dominik; García-Iglesias, Miguel; Bottari, Giovanni; Torres, Tomás; Jux, Norbert; Drewello, Thomas</p> <p>2016-02-21</p> <p>A protocol is developed for the coordination of the formate anion (HCOO(-)) to neutral metalloporphyrins (<span class="hlt">Pors</span>) and -phthalocyanines (Pcs) containing divalent metals as a means to improve their ion formation in electrospray ionization (ESI). This method is particularly useful when the oxidation of the neutral metallomacrocycle fails. While focusing on Zn(II)<span class="hlt">Pors</span> and Zn(II)Pcs, we show that formate is also readily attached to Mn(II), Mg(II) and Co(II)Pcs. However, for the Co(II)Pc secondary reactions can be observed. Upon collision-induced dissociation (CID), Zn(II)<span class="hlt">Por</span>/Pc·formate supramolecular complexes can undergo the loss of CO2 in combination with transfer of a hydride anion (H(-)) to the zinc metal center. Further dissociation leads to electron transfer and hydrogen atom loss, generating a route to the radical anion of the Zn(II)<span class="hlt">Por</span>/Pc without the need for electrochemical reduction, although the Zn(II)<span class="hlt">Por</span>/Pc may have a too low electron affinity to allow electron transfer directly from the formate anion. In addition to single <span class="hlt">Por</span> molecules, multi <span class="hlt">Por</span> arrays were successfully analyzed by this method. In this case, multiple addition of formate occurs, giving rise to multiply charged species. In these multi <span class="hlt">Por</span> arrays, complexation of the formate anion occurs by two surrounding <span class="hlt">Por</span> units (sandwich). Therefore, the maximum attainment of formate anions in these arrays corresponds to the number of such sandwich complexes rather than the number of porphyrin moieties. The same bonding motif leads to dimers of the composition [(Zn(II)<span class="hlt">Por</span>/Pc)2·HCOO](-). In these, the formate anion can act as a structural probe, allowing the distinction of isomeric ions with the formate bridging two macrocycles or being attached to a dimer of directly connected macrocycles.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27824646','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27824646"><span>Fecal Calprotectin Levels Are Closely Correlated with the Absence of Relevant Mucosal Lesions in Postoperative Crohn's Disease.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Garcia-Planella, Esther; Mañosa, Míriam; Cabré, Eduard; Marín, Laura; Gordillo, Jordi; Zabana, Yamile; Boix, Jaume; Sáinz, Sergio; Domènech, Eugeni</p> <p>2016-12-01</p> <p>Fecal calprotectin (FC) is the best noninvasive biomarker of disease activity in inflammatory bowel disease. Its correlation with endoscopic mucosal lesions could save inconvenient, expensive, and repeated endoscopic examinations in particular clinical settings. To assess the correlation between FC and the existence and severity of endoscopic postoperative recurrence (<span class="hlt">POR</span>), a group of clinically stable outpatients with Crohn's disease for whom an ileocolonoscopy was routinely planned to assess <span class="hlt">POR</span> were invited to collect a stool sample before starting bowel cleansing to measure FC. <span class="hlt">POR</span> was graded by means of Rutgeerts endoscopic score. One hundred nineteen ileocolonoscopies were included, 42% with endoscopic <span class="hlt">POR</span>. FC was significantly lower in the absence of endoscopic <span class="hlt">POR</span> and in the absence of any endoscopic lesion. The area under the receiver operating characteristic curve was 0.76 (95% confidence interval, 0.68-0.85) for the diagnosis of the absence of lesions and 0.75 (95% confidence interval, 0.66-0.84) for endoscopic <span class="hlt">POR</span>. Better sensitivity and negative predictive value were observed when combining FC and serum C-reactive protein (CRP), leading to a sensitivity of 82%, a specificity of 53%, and negative and positive predictive values of 81% and 54%, respectively, for the prediction of endoscopic <span class="hlt">POR</span> with a combination of FC 100 μg/g and CRP 5 mg/L cutoff values. FC correlates closely with endoscopic <span class="hlt">POR</span> in clinically stable postoperative patients with Crohn's disease and, when used in combination with CRP, might save endoscopic examinations and allow for a high-grade suspicion of endoscopic <span class="hlt">POR</span> in the long-term monitoring of these patients.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016SPIE.9998E..21A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016SPIE.9998E..21A"><span>Satellite image based methods for fuels maps updating</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Alonso-Benito, Alfonso; Hernandez-Leal, Pedro A.; Arbelo, Manuel; Gonzalez-Calvo, Alejandro; Moreno-Ruiz, Jose A.; Garcia-Lazaro, Jose R.</p> <p>2016-10-01</p> <p>Regular updating of fuels maps is important for forest fire management. Nevertheless complex and time consuming field work is usually necessary for this purpose, which prevents a more frequent update. That is why the assessment of the usefulness of satellite data and the development of remote sensing techniques that enable the automatic updating of these maps, is of vital interest. In this work, we have tested the use of the spectral bands of OLI (Operational Land Imager) sensor on board Landsat 8 satellite, for updating the fuels map of El <span class="hlt">Hierro</span> Island (Spain). From previously digitized map, a set of 200 reference plots for different fuel types was created. A 50% of the plots were randomly used as a training set and the rest were considered for validation. Six supervised and 2 unsupervised classification methods were applied, considering two levels of detail. A first level with only 5 classes (Meadow, Brushwood, Undergrowth canopy cover >50%, Undergrowth canopy cover <15%, and Xeric formations), and the second one containing 19 fuel types. The level 1 classification methods yielded an overall accuracy ranging from 44% for Parellelepided to an 84% for Maximun Likelihood. Meanwhile, level 2 results showed at best, an unacceptable overall accuracy of 34%, which prevents the use of this data for such a detailed characterization. Anyway it has been demonstrated that in some conditions, images of medium spatial resolution, like Landsat 8-OLI, could be a valid tool for an automatic upgrade of fuels maps, minimizing costs and complementing traditional methodologies.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25407440','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25407440"><span>The evolutionary history of Afrocanarian blue tits inferred from genomewide SNPs.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Gohli, Jostein; Leder, Erica H; Garcia-Del-Rey, Eduardo; Johannessen, Lars Erik; Johnsen, Arild; Laskemoen, Terje; Popp, Magnus; Lifjeld, Jan T</p> <p>2015-01-01</p> <p>A common challenge in phylogenetic reconstruction is to find enough suitable genomic markers to reliably trace splitting events with short internodes. Here, we present phylogenetic analyses based on genomewide single-nucleotide polymorphisms (SNPs) of an enigmatic avian radiation, the subspecies complex of Afrocanarian blue tits (Cyanistes teneriffae). The two sister species, the Eurasian blue tit (Cyanistes caeruleus) and the azure tit (Cyanistes cyanus), constituted the out-group. We generated a large data set of SNPs for analysis of population structure and phylogeny. We also adapted our protocol to utilize degraded DNA from old museum skins from Libya. We found strong population structuring that largely confirmed subspecies monophyly and constructed a coalescent-based phylogeny with full support at all major nodes. The results are consistent with a recent hypothesis that La Palma and Libya are relic populations of an ancient Afrocanarian blue tit, although a small data set for Libya could not resolve its position relative to La Palma. The birds on the eastern islands of Fuerteventura and Lanzarote are similar to those in Morocco. Together they constitute the sister group to the clade containing the other Canary Islands (except La Palma), in which El <span class="hlt">Hierro</span> is sister to the three central islands. Hence, extant Canary Islands populations seem to originate from multiple independent colonization events. We also found population divergences in a key reproductive trait, viz. sperm length, which may constitute reproductive barriers between certain populations. We recommend a taxonomic revision of this polytypic species, where several subspecies should qualify for species rank. © 2014 John Wiley & Sons Ltd.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014JSR....87...68B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014JSR....87...68B"><span>Effects of a submarine eruption on the performance of two brown seaweeds</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Betancor, Séfora; Tuya, Fernando; Gil-Díaz, Teba; Figueroa, Félix L.; Haroun, Ricardo</p> <p>2014-03-01</p> <p>World oceans are becoming more acidic as a consequence of CO2 anthropogenic emissions, with multiple physiological and ecological implications. So far, our understanding is mainly limited to some species through in vitro experimentation. In this study, we took advantage of a recent submarine eruption (from October 2011 to March 2012) at ~ 1 nautical mile offshore El <span class="hlt">Hierro</span> Island (Canary Islands, central east Atlantic) to determine whether altered physical-chemical conditions, mainly sudden natural ocean acidification, affected the morphology, photosynthesis (in situ Chl-a fluorescence) and physiological performance (photo-protective mechanisms and oxidative stress) of the conspicuous brown seaweeds Padina pavonica-a species with carbonate deposition - and Lobophora variegata-a species without carbonate on thallus surfaces - , both with similar morphology. Seaweeds were sampled twice: November 2011 (eruptive phase with a pH drop of ca. 1.22 units relative to standard conditions) and March 2012 (post-eruptive phase with a pH of ca. 8.23), on two intertidal locations adjacent to the eruption and at a control location. P. pavonica showed decalcification and loss of photo-protective compounds and antioxidant activity at locations affected by the eruption, behaving as a sun-adapted species during lowered pH conditions. At the same time, L. variegata suffered a decrease in photo-protective compounds and antioxidant activity during the volcanic event, but its photosynthetic performance remained unaltered. These results reinforce the idea that calcareous seaweeds, as a whole, are more sensitive than non-calcareous seaweeds to alter their performance under scenarios of reduced pH.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25767759','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25767759"><span>Anti-inflammatory, Analgesic and Antiulcer properties of Porphyra vietnamensis.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bhatia, Saurabh; Sharma, Kiran; Sharma, Ajay; Nagpal, Kalpana; Bera, Tanmoy</p> <p>2015-01-01</p> <p>Aim of the present work was to investigate the anti-inflammatory, analgesic and antiulcer effects of red seaweed Porphyra vietnamensis (P. vietnamenis). Aqueous (<span class="hlt">POR</span>) and alcoholic (PE) fractions were successfully isolated from P. vietnamenis. Further biological investigations were performed using a classic test of paw edema induced by carrageenan, writhing induced by acetic acid, hot plate method and naproxen induced gastro-duodenal ulcer. Among the fractions <span class="hlt">POR</span> showed better activity. <span class="hlt">POR</span> and PE significantly (p < 0.05) reduced carrageenan induced paw edema in a dose dependent manner. In the writhing test <span class="hlt">POR</span> significantly (p < 0.05) reduced abdominal writhes than PE. In hot plate method <span class="hlt">POR</span> showed better analgesic activity than PE. <span class="hlt">POR</span> showed comparable ulcers reducing potential (p<0.01) to that of omeprazole, and has more ulcer reducing potential then PE. The results of this study demonstrated that P. vietnamenis aqueous fraction possesses biological activity that is close to the standards taken for the treatment of peripheral painful or/and inflammatory and ulcer conditions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2011-05-03/pdf/2011-10766.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2011-05-03/pdf/2011-10766.pdf"><span>76 FR 24857 - Fresh Garlic From the People's Republic of China: Preliminary Intent To Rescind New Shipper Reviews</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2011-05-03</p> <p>... sales are not bona fide. As such, we are preliminarily rescinding the NSR for Shenzhen Bainong and... sale or entry during the original, unextended <span class="hlt">POR</span>, and therefore we are preliminarily rescinding the...-annual NSR <span class="hlt">POR</span>. When the sale of the subject merchandise occurs within the <span class="hlt">POR</span> specified by the...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22202905-ortholog-fara-aspergillus-nidulans-implicated-transcriptional-activation-genes-involved-fatty-acid-utilization-yeast-yarrowia-lipolytica','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22202905-ortholog-fara-aspergillus-nidulans-implicated-transcriptional-activation-genes-involved-fatty-acid-utilization-yeast-yarrowia-lipolytica"><span>An ortholog of farA of Aspergillus nidulans is implicated in the transcriptional activation of genes involved in fatty acid utilization in the yeast Yarrowia lipolytica</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Poopanitpan, Napapol; Kobayashi, Satoshi; Fukuda, Ryouichi</p> <p>2010-11-26</p> <p>Research highlights: {yields} <span class="hlt">POR</span>1 is a Yarrowia lipolytica ortholog of farA involved in fatty acid response in A. nidulans. {yields} Deletion of <span class="hlt">POR</span>1 caused growth defects on fatty acids. {yields} {Delta}<span class="hlt">por</span>1 strain exhibited defects in the induction of genes involved in fatty acid utilization. -- Abstract: The yeast Yarrowia lipolytica effectively utilizes hydrophobic substrates such as fatty acids and n-alkanes. To identify a gene(s) regulating fatty acid utilization in Y. lipolytica, we first studied homologous genes to OAF1 and PIP2 of Saccharomyces cerevisiae, but their disruption did not change growth on oleic acid at all. We next characterized a Y.more » lipolytica gene, <span class="hlt">POR</span>1 (primary oleate regulator 1), an ortholog of farA encoding a transcriptional activator that regulates fatty acid utilization in Aspergillus nidulans. The deletion mutant of <span class="hlt">POR</span>1 was defective in the growth on various fatty acids, but not on glucose, glycerol, or n-hexadecane. It exhibited slight defect on n-decane. The transcriptional induction of genes involved in {beta}-oxidation and peroxisome proliferation by oleate was distinctly diminished in the {Delta}<span class="hlt">por</span>1 strains. These data suggest that <span class="hlt">POR</span>1 encodes a transcriptional activator widely regulating fatty acid metabolism in Y. lipolytica.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3533425','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3533425"><span>NADPH–Cytochrome P450 Oxidoreductase: Roles in Physiology, Pharmacology, and Toxicology</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ding, Xinxin; Wolf, C. Roland; Porter, Todd D.; Pandey, Amit V.; Zhang, Qing-Yu; Gu, Jun; Finn, Robert D.; Ronseaux, Sebastien; McLaughlin, Lesley A.; Henderson, Colin J.; Zou, Ling; Flück, Christa E.</p> <p>2013-01-01</p> <p>This is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology 2012 meeting in San Diego, California, on April 25, 2012. The symposium speakers summarized and critically evaluated our current understanding of the physiologic, pharmacological, and toxicological roles of NADPH–cytochrome P450 oxidoreductase (<span class="hlt">POR</span>), a flavoprotein involved in electron transfer to microsomal cytochromes P450 (P450), cytochrome b5, squalene mono-oxygenase, and heme oxygenase. Considerable insight has been derived from the development and characterization of mouse models with conditional <span class="hlt">Por</span> deletion in particular tissues or partial suppression of <span class="hlt">POR</span> expression in all tissues. Additional mouse models with global or conditional hepatic deletion of cytochrome b5 are helping to clarify the P450 isoform- and substrate-specific influences of cytochrome b5 on P450 electron transfer and catalytic function. This symposium also considered studies using siRNA to suppress <span class="hlt">POR</span> expression in a hepatoma cell–culture model to explore the basis of the hepatic lipidosis phenotype observed in mice with conditional deletion of <span class="hlt">Por</span> in liver. The symposium concluded with a strong translational perspective, relating the basic science of human <span class="hlt">POR</span> structure and function to the impacts of <span class="hlt">POR</span> genetic variation on human drug and steroid metabolism. PMID:23086197</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22246422','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22246422"><span>Influence of cytochrome P450 oxidoreductase genetic polymorphisms on CYP1A2 activity and inducibility by smoking.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dobrinas, Maria; Cornuz, Jacques; Pedrido, Leticia; Eap, Chin B</p> <p>2012-02-01</p> <p>Cytochrome P4501A2 (CYP1A2) presents a high interindividual variability in its activity and also in its inducibility by smoking. Cytochrome P450 oxidoreductase (<span class="hlt">POR</span>) is an electron transfer protein that catalyzes the activity of several cytochromes P450. We aimed to study the influence of <span class="hlt">POR</span> genetic polymorphisms on CYP1A2 activity while smoking and after smoking cessation, as well as on CYP1A2 inducibility. CYP1A2 activity was determined by the paraxanthine/caffeine ratio in 184 smokers and in 113 of these smokers who were abstinent during a 4-week period. Participants were genotyped for <span class="hlt">POR</span> rs17148944G>A, rs10239977C>T, rs3815455C>T, rs2286823G>A, rs2302429G>A, and rs1057868C>T (<span class="hlt">POR</span>*28) polymorphisms. While smoking, none of the tested <span class="hlt">POR</span> polymorphisms showed a significant influence on CYP1A2 activity. After smoking cessation, significantly higher CYP1A2 activity was found in <span class="hlt">POR</span> rs2302429A carriers (P=0.038) and in carriers of rs17148944G-rs10239977C-rs3815455T-rs2286823G-rs2302429A-rs1057868T haplotype (P=0.038), whereas carriers of <span class="hlt">POR</span> rs2286823A (P=0.031) and of the rs17148944G-rs10239977C-rs3815455C-rs2286823A-rs2302429G-rs1057868C haplotype (P=0.031) had decreased CYP1A2 activity. In the complete regression model, only <span class="hlt">POR</span> rs2302429G>A showed a significant effect (P=0.017). No influence of <span class="hlt">POR</span> genotypes or haplotypes was observed on the inducibility of CYP1A2. <span class="hlt">POR</span> genetic polymorphisms influence CYP1A2 basal but not induced activity and do not seem to influence CYP1A2 inducibility. Future work is warranted to identify other clinical and genetic factors that may explain the variability in CYP1A2 activity and inducibility by smoking.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22207482-deletion-p399-sub-nadph-cytochrome-p450-oxidoreductase-results-partial-mixed-oxidase-deficiency','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22207482-deletion-p399-sub-nadph-cytochrome-p450-oxidoreductase-results-partial-mixed-oxidase-deficiency"><span>Deletion of P399{sub E}401 in NADPH cytochrome P450 oxidoreductase results in partial mixed oxidase deficiency</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Flueck, Christa E., E-mail: christa.flueck@dkf.unibe.ch; Mallet, Delphine; Hofer, Gaby</p> <p>2011-09-09</p> <p>Highlights: {yields} Mutations in human <span class="hlt">POR</span> cause congenital adrenal hyperplasia. {yields} We are reporting a novel 3 amino acid deletion mutation in <span class="hlt">POR</span> P399{sub E}401del. {yields} <span class="hlt">POR</span> mutation P399{sub E}401del decreased P450 activities by 60-85%. {yields} Impairment of steroid metabolism may be caused by multiple hits. {yields} Severity of aromatase inhibition is related to degree of in utero virilization. -- Abstract: P450 oxidoreductase (<span class="hlt">POR</span>) is the electron donor for all microsomal P450s including steroidogenic enzymes CYP17A1, CYP19A1 and CYP21A2. We found a novel <span class="hlt">POR</span> mutation P399{sub E}401del in two unrelated Turkish patients with 46,XX disorder of sexual development. Recombinant PORmore » proteins were produced in yeast and tested for their ability to support steroid metabolizing P450 activities. In comparison to wild-type <span class="hlt">POR</span>, the P399{sub E}401del protein was found to decrease catalytic efficiency of 21-hydroxylation of progesterone by 68%, 17{alpha}-hydroxylation of progesterone by 76%, 17,20-lyase action on 17OH-pregnenolone by 69%, aromatization of androstenedione by 85% and cytochrome c reduction activity by 80%. Protein structure analysis of the three amino acid deletion P399{sub E}401 revealed reduced stability and flexibility of the mutant. In conclusion, P399{sub E}401del is a novel mutation in <span class="hlt">POR</span> that provides valuable genotype-phenotype and structure-function correlation for mutations in a different region of <span class="hlt">POR</span> compared to previous studies. Characterization of P399{sub E}401del provides further insight into specificity of different P450s for interaction with <span class="hlt">POR</span> as well as nature of metabolic disruptions caused by more pronounced effect on specific P450s like CYP17A1 and aromatase.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25365138','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25365138"><span>"Spider"-shaped porphyrins with conjugated pyridyl anchoring groups as efficient sensitizers for dye-sensitized solar cells.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stangel, Christina; Bagaki, Anthi; Angaridis, Panagiotis A; Charalambidis, Georgios; Sharma, Ganesh D; Coutsolelos, Athanasios G</p> <p>2014-11-17</p> <p>Two novel "spider-shaped" porphyrins, meso-tetraaryl-substituted 1PV-<span class="hlt">Por</span> and zinc-metalated 1PV-Zn-<span class="hlt">Por</span>, bearing four oligo(p-phenylenevinylene) (oPPV) pyridyl groups with long dodecyloxy chains on the phenyl groups, have been synthesized. The presence of four pyridyl groups in both porphyrins, which allow them to act as anchoring groups upon coordination to various Lewis acid sites, the conjugated oPPV bridges, which offer the possibility of electronic communication between the porphyrin core and the pyridyl groups, and the dodecyloxy groups, which offer the advantage of high solubility in a variety of organic solvents of different polarities and could prevent porphyrin aggregation, renders porphyrins 1PV-<span class="hlt">Por</span> and 1PV-Zn-<span class="hlt">Por</span> very promising sensitizers for dye-sensitized solar cells (DSSCs). Photophysical measurements, together with electrochemistry experiments and density functional theory calculations, suggest that both porphyrins have frontier molecular orbital energy levels that favor electron injection and dye regeneration in DSSCs. Solar cells sensitized by 1PV-<span class="hlt">Por</span> and 1PV-Zn-<span class="hlt">Por</span> were fabricated, and it was found that they show power conversion efficiencies (PCEs) of 3.28 and 5.12%, respectively. Photovoltaic measurements (J-V curves) together with incident photon-to-electron conversion efficiency spectra of the two cells reveal that the higher PCE value of the DSSC based on 1PV-Zn-<span class="hlt">Por</span> is ascribed to higher short-circuit current (Jsc), open-circuit voltage (Voc), and dye loading values. Emission spectra and electrochemistry experiments suggest a greater driving force for injection of the photogenerated electrons into the TiO2 conduction band for 1PV-Zn-<span class="hlt">Por</span> rather than its free-base analogue. Furthermore, electrochemical impedance spectroscopy measurements prove that the utilization of 1PV-Zn-<span class="hlt">Por</span> as a sensitizer offers a high charge recombination resistance and, therefore, leads to a longer electron lifetime.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4352535','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4352535"><span>Anti-inflammatory, Analgesic and Antiulcer properties of Porphyra vietnamensis</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Bhatia, Saurabh; Sharma, Kiran; Sharma, Ajay; Nagpal, Kalpana; Bera, Tanmoy</p> <p>2015-01-01</p> <p>Objectives: Aim of the present work was to investigate the anti-inflammatory, analgesic and antiulcer effects of red seaweed Porphyra vietnamensis (P. vietnamenis). Materials and Methods: Aqueous (<span class="hlt">POR</span>) and alcoholic (PE) fractions were successfully isolated from P. vietnamenis. Further biological investigations were performed using a classic test of paw edema induced by carrageenan, writhing induced by acetic acid, hot plate method and naproxen induced gastro-duodenal ulcer. Results: Among the fractions <span class="hlt">POR</span> showed better activity. <span class="hlt">POR</span> and PE significantly (p < 0.05) reduced carrageenan induced paw edema in a dose dependent manner. In the writhing test <span class="hlt">POR</span> significantly (p < 0.05) reduced abdominal writhes than PE. In hot plate method <span class="hlt">POR</span> showed better analgesic activity than PE. <span class="hlt">POR</span> showed comparable ulcers reducing potential (p<0.01) to that of omeprazole, and has more ulcer reducing potential then PE. Conclusions: The results of this study demonstrated that P. vietnamenis aqueous fraction possesses biological activity that is close to the standards taken for the treatment of peripheral painful or/and inflammatory and ulcer conditions. PMID:25767759</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1369259','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1369259"><span>La Resonancia J/$$\\psi$$ y Sus Implicaciones Para La Masa Del W (in Spanish)</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Sanchez-Hernandez, Alberto</p> <p></p> <p>Es un placer agradecer a mi asesor el doctor Heriberto Castilla Valdez <span class="hlt">por</span> brindarme sus conocimientos, experiencia y paciencia en el desarrollo de esta tesis; tambien quiero agradecer al profesor H.E. Fisk, <span class="hlt">por</span> su apoyo econemico en mi estancia en Fermilab. De igual forma agradezco a los doctores Arturo Fernandez Telles, Miguel Angel Perez Angen y Rebeca Juarez Wisozka quienes me introdujeron al campo de la fisica experimental de altas energfas. Agradezco tambien a Maribel Rios Cruz, Ruben Flores Mendieta, Juan Morales Corona, Fabiola Vazquez Valencia, Salvador Carrillo Moreno y Cecilia Uribe Estrada <span class="hlt">por</span> su amistad y compaiierismo durante elmore » desarrollo de mi maestria. Un especial agradecimiento a Ian Adam y Kina Denisenko <span class="hlt">por</span> su valiosa ayuda, comentarios y discusiones durante mi estancia en Fermilab. <span class="hlt">Por</span> ultimo quisiera agradecer a mis profesores, amigos y familiares quienes siempre me apoyaron y alentaron y al Consejo N acional de Ciencia y Tecnologfa asf como al Departamento de Fisica de Cinvestav <span class="hlt">por</span> su apoyo econemlco.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22649654-influence-doping-type-level-morphology-porous-si-formed-galvanic-etching','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22649654-influence-doping-type-level-morphology-porous-si-formed-galvanic-etching"><span>Influence of the doping type and level on the morphology of porous Si formed by galvanic etching</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Pyatilova, O. V., E-mail: 5ilova87@gmail.com; Gavrilov, S. A.; Shilyaeva, Yu. I.</p> <p></p> <p>The formation of porous silicon (<span class="hlt">por</span>-Si) layers by the galvanic etching of single-crystal Si samples (doped with boron or phosphorus) in an HF/C{sub 2}H{sub 5}OH/H{sub 2}O{sub 2} solution is investigated. The <span class="hlt">por</span>-Si layers are analyzed by the capillary condensation of nitrogen and scanning electron microscopy (SEM). The dependences of the morphological characteristics of <span class="hlt">por</span>-Si (pore diameter, specific surface area, pore volume, and thickness of the pore walls), which determine the <span class="hlt">por</span>-Si combustion kinetics, on the dopant type and initial wafer resistivity are established.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27383928','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27383928"><span>Pre-treatment with dexamethasone attenuates experimental ventilator-induced lung injury.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Reis, Fernando Fonseca Dos; Reboredo, Maycon de Moura; Lucinda, Leda Marília Fonseca; Bianchi, Aydra Mendes Almeida; Rabelo, Maria Aparecida Esteves; Fonseca, Lídia Maria Carneiro da; Oliveira, Júlio César Abreu de; Pinheiro, Bruno Valle</p> <p>2016-01-01</p> <p>é-LPIVM (grupo dexametasona); administração de salina pré-LPIVM (grupo controle); e somente ventilação (grupo sham). A LPIVM foi realizada <span class="hlt">por</span> ventilação com volume corrente alto. Os animais dos grupos dexametasona e controle foram sacrificados em 0, 4, 24 e 168 h após LPIVM. Analisamos gasometria arterial, edema pulmonar, contagens de células (totais e diferenciais) no lavado broncoalveolar e histologia de tecido pulmonar. Em 0, 4 e 24 h após LPIVM, os escores de lesão pulmonar <span class="hlt">aguda</span> (LPA) foram maiores no grupo controle que no grupo sham (p < 0,05). A administração de dexametasona antes da LPIVM reduziu a gravidade da lesão pulmonar. Em 4 e 24 h após a indução, o escore de LPA no grupo dexametasona não foi significativamente diferente daquele observado no grupo sham e foi menor que o observado no grupo controle (p < 0,05). As contagens de neutrófilos no lavado broncoalveolar estavam aumentadas nos grupos controle e dexametasona, com pico em 4 h após LPIVM (p < 0,05). Entretanto, as contagens de neutrófilos foram menores no grupo dexametasona que no grupo controle em 4 e 24 h após LPIVM (p < 0,05). O pré-tratamento com dexametasona também impediu o comprometimento da oxigenação após a indução visto no grupo controle. A administração de dexametasona antes de LPIVM atenua os efeitos da lesão em ratos Wistar. Os mecanismos moleculares dessa lesão e o possível papel clínico dos corticosteroides na LPIVM ainda precisam ser elucidados.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active"><span>17</span></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_17 --> <div id="page_18" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="341"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/9171424','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/9171424"><span>Evidence for the bacterial origin of genes encoding fermentation enzymes of the amitochondriate protozoan parasite Entamoeba histolytica.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rosenthal, B; Mai, Z; Caplivski, D; Ghosh, S; de la Vega, H; Graf, T; Samuelson, J</p> <p>1997-06-01</p> <p>Entamoeba histolytica is an amitochondriate protozoan parasite with numerous bacterium-like fermentation enzymes including the pyruvate:ferredoxin oxidoreductase (<span class="hlt">POR</span>), ferredoxin (FD), and alcohol dehydrogenase E (ADHE). The goal of this study was to determine whether the genes encoding these cytosolic E. histolytica fermentation enzymes might derive from a bacterium by horizontal transfer, as has previously been suggested for E. histolytica genes encoding heat shock protein 60, nicotinamide nucleotide transhydrogenase, and superoxide dismutase. In this study, the E. histolytica <span class="hlt">por</span> gene and the adhE gene of a second amitochondriate protozoan parasite, Giardia lamblia, were sequenced, and their phylogenetic positions were estimated in relation to <span class="hlt">POR</span>, ADHE, and FD cloned from eukaryotic and eubacterial organisms. The E. histolytica <span class="hlt">por</span> gene encodes a 1,620-amino-acid peptide that contained conserved iron-sulfur- and thiamine pyrophosphate-binding sites. The predicted E. histolytica <span class="hlt">POR</span> showed fewer positional identities to the <span class="hlt">POR</span> of G. lamblia (34%) than to the <span class="hlt">POR</span> of the enterobacterium Klebsiella pneumoniae (49%), the cyanobacterium Anabaena sp. (44%), and the protozoan Trichomonas vaginalis (46%), which targets its <span class="hlt">POR</span> to anaerobic organelles called hydrogenosomes. Maximum-likelihood, neighbor-joining, and parsimony analyses also suggested as less likely E. histolytica <span class="hlt">POR</span> sharing more recent common ancestry with G. lamblia <span class="hlt">POR</span> than with <span class="hlt">POR</span> of bacteria and the T. vaginalis hydrogenosome. The G. lamblia adhE encodes an 888-amino-acid fusion peptide with an aldehyde dehydrogenase at its amino half and an iron-dependent (class 3) ADH at its carboxy half. The predicted G. lamblia ADHE showed extensive positional identities to ADHE of Escherichia coli (49%), Clostridium acetobutylicum (44%), and E. histolytica (43%) and lesser identities to the class 3 ADH of eubacteria and yeast (19 to 36%). Phylogenetic analyses inferred a closer relationship of the E</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22086318','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22086318"><span>[Identifying the severe acute pancreatitis].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Acevedo Tizón, Anais; Targarona Modena, Javier; Málaga Rodríguez, Germán; Barreda Cevasco, Luis</p> <p>2011-01-01</p> <p>To compare patients with acute necrotizing pancreatitis without any additional complications during their hospital stay (Group A) versus patients with Acute Necrotizing Pancreatitis with additional complications during their hospital stay (Group B). Data obtained from a pre-existing base from hospitalized patients with diagnosis of acute necrotizing pancreatitis in the specialized unit of "Unidad de Pancreatitis <span class="hlt">Aguda</span> Grave del Hospital Nacional Edgardo Rebagliati Martins" between 2000 and 2010. Data included patients with diagnosis of acute necrotizing pancreatitis, of ages 18 and over. Data from 215 patients with acute necrotizing pancreatitis was included. Patients from Group A represented 32% (68) and from Group B 68% (147). Group A had a average of 39 hospitalized days and Group B had an average of 56 days (p=0.01). From Group A 22% had more than 50% of necrosis while 43% of Group B had this extension of necrosis (p <0.05, OR 3.4, IC (1.12-10)). Of the 14 deaths of the population, all part of Group B, 12 of them had more than 50% of necrosis. Not every patient classified as severe acute pancreatitis, based on the presence of necrosis, behave likewise. It is an extended necrosis, described as more than 50% of pancreatic necrosis, and not the presence itself which will determine additional complications during the course of disease and a greater mortality.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26242294','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26242294"><span>First example of a modular porphyrinoid assembly capable of stabilizing different metal ions in a single molecular scaffold.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Murugavel, Muthuchamy; Reddy, R V Ramana; Dey, Dhananjay; Sankar, Jeyaraman</p> <p>2015-10-05</p> <p>We report the synthesis and characterization of porphyrin-corrole-porphyrin (<span class="hlt">Por-Cor-Por</span>) hybrids directly linked at the meso-meso positions for the first time. The stability and solubility of the trimer are carefully balanced by adding electron-withdrawing substituents to the corrole ring and sterically bulky groups on the porphyrins. The new hybrids are capable of stabilizing more than one metal ion in a single molecular scaffold. The versatility of the triad has been demonstrated by successfully stabilizing homo- (Ni) and heterotrinuclear (Ni-Cu-Ni) coordination motifs. The solid-state structure of the Ni<span class="hlt">Por-CuCor-Por</span>Ni hybrid was revealed by single-crystal X-ray diffraction studies. The Ni(II) porphyrins are significantly ruffled and tilted by 83° from the plane of corrole. The robustness of the synthesized hybrids was reflected in the electrochemical investigations and the redox behaviour of the hybrids show that the oxidation processes are mostly corrole-centred. In particular it is worth noting that the <span class="hlt">Por-Cor-Por</span> hybrid can further be manipulated due to the presence of substituent-free meso-positions on both the terminals. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27678049','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27678049"><span>Management of post-operative Crohn's disease in 2017: where do we go from here?</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nguyen, Vu; Kanth, Rajan; Gazo, Joshua; Sorrentino, Dario</p> <p>2016-11-01</p> <p>Postoperative recurrence (<span class="hlt">POR</span>) of Crohn's disease is common after surgical resection. How to best manage <span class="hlt">POR</span> remains uncertain. Areas covered: In this review, we will first describe the natural course and the best modalities to diagnose this surgical sequela. We will then focus on the potential risk factors for relapse and highlight the main shortcomings in the current study designs and endoscopic and clinical scoring systems, which may partly explain the unexpected outcomes of recent clinical trials. Finally, we will propose a strategy to address the management of <span class="hlt">POR</span>. Expert commentary: Anti-tumor necrosis factor (Anti-TNF) agents are the most effective therapy to prevent <span class="hlt">POR</span> in Crohn's disease. Patient risk stratification and active monitoring with scheduled ileocolonoscopy are cornerstones of optimal <span class="hlt">POR</span> management. Further studies are needed to address areas of uncertainty including timing and duration of therapy and the role of therapeutic drug monitoring in this setting.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28865913','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28865913"><span>Developing a military nurse scientist program of research: A military women's health exemplar.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Trego, Lori Lyn</p> <p></p> <p>Developing a feasible, fundable, and sustainable program of research (<span class="hlt">POR</span>) is an essential career goal in research. Nurse scientists can lay the foundation for a salient <span class="hlt">POR</span> as early as during their doctoral studies. The ensuing years of postdoctoral experiences are informative as they expand their research skills and knowledge around their research area of interest. Following graduation from a doctoral research program, novice military nurse scientists (MNS) are placed in positions that are conducive to fostering a <span class="hlt">POR</span>. Military organizational support and the rich experiences of peers and mentors facilitate early career development of MNS. The purpose of this article is to present a conceptual framework for research career development of the novice MNS. Using an exemplar <span class="hlt">POR</span> in military women's health, the concepts are operationalized to illustrate how the military environment enhances the development of a successful <span class="hlt">POR</span>. Copyright © 2017 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3147073','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3147073"><span>Association between arsenic exposure from drinking water and proteinuria: results from the Health Effects of Arsenic Longitudinal Study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Chen, Yu; Parvez, Faruque; Liu, Mengling; Pesola, Gene R; Gamble, Mary V; Slavkovich, Vesna; Islam, Tariqul; Ahmed, Alauddin; Hasan, Rabiul; Graziano, Joseph H; Ahsan, Habibul</p> <p>2011-01-01</p> <p>Background Proteinuria has been recognized as a marker for an increased risk of chronic renal disease. It is unclear whether arsenic (As) exposure from drinking water is associated with proteinuria. Methods We evaluated the association between As exposure from drinking water and proteinuria in 11 122 participants in the Health Effects of Arsenic Longitudinal Study (HEALS). Proteinuria was detected by urinary dipstick tests at baseline and at 2-year intervals. As exposure variables included baseline well As and changes in urinary As during follow-up modelled as time-dependent variables in the analyses. Results At baseline, well As was positively related to prevalence of proteinuria; prevalence odds ratios (<span class="hlt">PORs</span>) for proteinuria in increasing quintiles of well As (≤7, 8–39, 40–91, 92–179 and 180–864 µg/l) were 1.00 (ref), <span class="hlt">POR</span> 0.99 [95% confidence interval (CI) 0.77–1.27], <span class="hlt">POR</span> 1.23 (95% CI 0.97–1.57), <span class="hlt">POR</span> 1.50 (95% CI 1.18–1.89) and <span class="hlt">POR</span> 1.59 (95% CI 1.26–2.00) (P for trend <0.01). Hazard ratios for incidence of proteinuria were <span class="hlt">POR</span> 0.83 (95% CI 0.67–1.03) and <span class="hlt">POR</span> 0.91 (95% CI 0.74–1.12) for participants with a decreasing level of >70 and 17–70 µg/l in urinary As over time, respectively, and were <span class="hlt">POR</span> 1.17 (95% CI 0.97–1.42) and <span class="hlt">POR</span> 1.42 (95% CI 1.16–1.73) for participants with an increasing level of 16–68 and >68 µg/l in urinary As over time, respectively, compared with the group with relatively little changes in urinary As as the reference group (urinary As −16 to 15 µg/l). Conclusion The findings suggest that there are adverse effects of As exposure on the risk of proteinuria and the effects are modifiable by recent changes in As exposure. PMID:21343184</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4795800','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4795800"><span>Recombinant Salivary Proteins of Phlebotomus orientalis are Suitable Antigens to Measure Exposure of Domestic Animals to Sand Fly Bites</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Sima, Michal; Ferencova, Blanka; Warburg, Alon; Rohousova, Iva; Volf, Petr</p> <p>2016-01-01</p> <p>Background Certain salivary proteins of phlebotomine sand flies injected into the host skin during blood-feeding are highly antigenic and elicit strong antibody-mediated immune responses in repeatedly-exposed hosts. These antibodies can be measured by enzyme-linked immuno sorbent assays (ELISAs) using salivary gland homogenates (SGHs) as the source of antigens and serve as a markers for exposure to biting sand flies. Large-scale screening for anti-sand fly saliva antibodies requires replacement of SGH with recombinant salivary proteins. In East Africa, Phlebotomus orientalis is the main vector of Leishmania donovani, a trypanosomatid parasite causing visceral leishmaniasis. We tested recombinant salivary proteins derived from Ph. orientalis saliva to study exposure of domestic animals to this sand fly species. Methodology/Principal Findings Antigenic salivary proteins from Ph. orientalis were identified by immunoblot and mass spectrometry. Recombinant apyrase r<span class="hlt">Por</span>SP15, yellow-related protein r<span class="hlt">Por</span>SP24, ParSP25-like protein r<span class="hlt">Por</span>SP65, D7-related protein r<span class="hlt">Por</span>SP67, and antigen 5-related protein r<span class="hlt">Por</span>SP76 were tested using ELISA with sera of domestic animals from L. donovani foci in Ethiopia where Ph. orientalis is present. Our results highlighted recombinant yellow-related protein r<span class="hlt">Por</span>SP24 as the most promising antigen, displaying a high positive correlation coefficient as well as good sensitivity and specificity when compared to SGH. This recombinant protein was the most suitable one for testing sera of dogs, sheep, and goats. In addition, a different antigen, r<span class="hlt">Por</span>SP65 was found efficacious for testing canine sera. Conclusions/Significance Recombinant salivary proteins of Ph. orientalis, specifically r<span class="hlt">Por</span>SP24, were shown to successfully substitute SGH in serological experiments to measure exposure of domestic animals to Ph. orientalis, the vector of L. donovani. The results suggest that r<span class="hlt">Por</span>SP24 might be a suitable antigen for detecting anti-Ph. orientalis antibody</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26986566','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26986566"><span>Recombinant Salivary Proteins of Phlebotomus orientalis are Suitable Antigens to Measure Exposure of Domestic Animals to Sand Fly Bites.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sima, Michal; Ferencova, Blanka; Warburg, Alon; Rohousova, Iva; Volf, Petr</p> <p>2016-03-01</p> <p>Certain salivary proteins of phlebotomine sand flies injected into the host skin during blood-feeding are highly antigenic and elicit strong antibody-mediated immune responses in repeatedly-exposed hosts. These antibodies can be measured by enzyme-linked immuno sorbent assays (ELISAs) using salivary gland homogenates (SGHs) as the source of antigens and serve as a markers for exposure to biting sand flies. Large-scale screening for anti-sand fly saliva antibodies requires replacement of SGH with recombinant salivary proteins. In East Africa, Phlebotomus orientalis is the main vector of Leishmania donovani, a trypanosomatid parasite causing visceral leishmaniasis. We tested recombinant salivary proteins derived from Ph. orientalis saliva to study exposure of domestic animals to this sand fly species. Antigenic salivary proteins from Ph. orientalis were identified by immunoblot and mass spectrometry. Recombinant apyrase r<span class="hlt">Por</span>SP15, yellow-related protein r<span class="hlt">Por</span>SP24, ParSP25-like protein r<span class="hlt">Por</span>SP65, D7-related protein r<span class="hlt">Por</span>SP67, and antigen 5-related protein r<span class="hlt">Por</span>SP76 were tested using ELISA with sera of domestic animals from L. donovani foci in Ethiopia where Ph. orientalis is present. Our results highlighted recombinant yellow-related protein r<span class="hlt">Por</span>SP24 as the most promising antigen, displaying a high positive correlation coefficient as well as good sensitivity and specificity when compared to SGH. This recombinant protein was the most suitable one for testing sera of dogs, sheep, and goats. In addition, a different antigen, r<span class="hlt">Por</span>SP65 was found efficacious for testing canine sera. Recombinant salivary proteins of Ph. orientalis, specifically r<span class="hlt">Por</span>SP24, were shown to successfully substitute SGH in serological experiments to measure exposure of domestic animals to Ph. orientalis, the vector of L. donovani. The results suggest that r<span class="hlt">Por</span>SP24 might be a suitable antigen for detecting anti-Ph. orientalis antibody-mediated reactions also in other host species.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013ArMiS..58..579U','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013ArMiS..58..579U"><span>A Comparison Between PSRK and GERG-2004 Equation of State for Simulation of Non-Isothermal Compressible Natural Gases Mixed with Hydrogen in Pipelines / <span class="hlt">Por</span>ównanie równań stanu opracowanych według metody PSRK oraz GERG-2004 wykorzystanych do symulacji zachowania ściśliwych mieszanin gazu ziemnego i wodoru w rurociągach, w warunkach przepływów nie-izotermicznych</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Uilhoorn, Frits E.</p> <p>2013-06-01</p> <p>In this work, the GERG-2004 equation of state based on a multi-fluid approximation explicit in the reduced Helmholtz energy is compared with the predictive Soave-Redlich-Kwong group contribution method. In the analysis, both equations of state are compared by simulating a non-isothermal transient flow of natural gas and mixed hydrogen-natural gas in pipelines. Besides the flow conditions also linepack-energy and energy consumption of the compressor station are computed. The gas flow is described by a set of partial differential equations resulting from the conservation of mass, momentum and energy. A pipeline section of the Yamal-Europe gas pipeline on Polish territory has been selected for the case study. W artykule dokonano <span class="hlt">por</span>ównania wyników uzyskanych przy wykorzystaniu równania stanu GERG- 2004 opartego na jawnym przybliżeniu wyników dla wielu cieczy w oparciu o zredukowaną energię Helmhotza oraz wyników uzyskanych w oparciu o metodę Soave-Redlich Kwonga. Obydwa równania stanu <span class="hlt">por</span>ównano poprzez przeprowadzenie symulacji stanów przejściowych przepływów gazu ziemnego oraz mieszanin gazu ziemnego i wodoru w rurociągach w warunkach przepływów nie-izotermicznych. Oprócz warunków przepływu, określono energię w napełnionym układzie oraz zużycie energii przez stację kompresora. Przepływ gazu opisano zbiorem równań różniczkowych cząstkowych, wyprowadzonych w oparciu o prawa zachowania masy, pędu i energii. Jako studium przypadku wybrano fragment rurociągu jamalskiego (Yamal- Europa) przebiegającego przez terytorium Polski.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2010PhDT.......523S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2010PhDT.......523S"><span>Weathering resistance of thin plasma polymer films on pre-coated steel =</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Serra, Ricardo Gil Henriques</p> <p></p> <p>O trabalho apresentado teve origem no projecto de investigacao “Tailored Thin Plasma Polymers Films for Surface Engineering of Coil Coated Steel”, financiado pelo Programa Europeu ECSC Steel Research. Sistemas de aco galvanizado pre-pintado em banda a base de poliester e poliuretano foram submetidos a um processo de polimerizacao <span class="hlt">por</span> plasma onde um filme fino foi depositado de modo a modificar as propriedades de superficie. Foram usados reactores de catodo oco, microondas e radio frequencia para a deposicao do polimero fino. Os sistemas preparados foram analisados de modo a verificar a influencia do processo de polimerizacao <span class="hlt">por</span> plasma na alteracao das propriedades barreira dos sistemas pre-pintados em banda. Foi estudado o efeito dos diferentes passos do processo de polimerizacao <span class="hlt">por</span> plasma, bem como o efeito de diferentes variaveis operatorias. A mistura precursora foi variada de modo a modificar as propriedades da superficie de modo a poder vir a obter maior hidrofobicidade, maior resistencia a marcas digitais, bem como maior facilidade de limpeza. Os testes foram conduzidos em solucao de NaCl 0,5 M. Para o trabalho foram usadas tecnicas de analise da morfologia da superficie como Microscopia de Forca Atomica e Microscopia Electronica de Varrimento. As propriedades electroquimicas dos sistemas foram estudadas <span class="hlt">por</span> Espectroscopia de Impedancia Electroquimica. A estrutura dos filmes gerados no processo de polimerizacao <span class="hlt">por</span> plasma foi caracterizada <span class="hlt">por</span> Microscopia de Transmissao Electronica. A modificacao das propriedades opticas devido ao processo de polimerizacao <span class="hlt">por</span> plasma foi tambem obtida.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28895678','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28895678"><span>Prognosis and cost-effectiveness of IVF in poor responders according to the Bologna Criteria.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Busnelli, Andrea; Somigliana, Edgardo</p> <p>2018-02-01</p> <p>Poor ovarian response (<span class="hlt">POR</span>) to controlled ovarian hyperstimulation for in vitro fertilization (IVF) is one of the most challenging issue in the field of reproductive medicine. However, even if improving IVF outcome in poor responders (<span class="hlt">PORs</span>) represents a main priority, the lack of a unique definition of <span class="hlt">POR</span> has hampered research in this area. In order to overcome this impediment, an ESHRE Campus Workshop was organized in Bologna in 2010 and reached a consensus on the criteria for the diagnosis of <span class="hlt">POR</span> ("Bologna Criteria"). In this review we aimed to estimate the prognostic potential of the ESHRE definition, to elucidate its possible weaknesses and to analyze the economic aspects of IVF in a population of poor responders (<span class="hlt">PORs</span>). Available evidence confirmed that the Bologna criteria are able to select a population with a poor IVF prognosis thus supporting their validity. Nonetheless, different aspects of the definition have been criticized. The main points of debate concern the homogeneity of the population identified, the cut-off values chosen for the ovarian reserve tests and the risks factors other than age associated with <span class="hlt">POR</span>. Data concerning the economic profile of IVF in <span class="hlt">PORs</span> are scanty. The only published study on the argument showed that IVF in these cases is not cost-effective. However, considering the potential substantial impact of cost-effectiveness analyses on public health policies, there is the need for further and independent validations.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2002BAAA...45....2Z','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2002BAAA...45....2Z"><span>Estimación de pequeñas perturbaciones en satélites geocéntricos como un problema inverso</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zadunaisky, P. E.</p> <p></p> <p>El movimiento geocéntrico de un satélite artificial es simulado automáticamente <span class="hlt">por</span> un sistema de ecuaciones diferenciales de segundo orden que incluyen dos funciones perturbadoras. La primera representa el segundo término del potencial gravitatorio de la Tierra y la segunda corresponde al frenado atmosférico. Asumiendo como conocidas, <span class="hlt">por</span> hipótesis o <span class="hlt">por</span> mediciones, la posición y velocidad del satélite en instantes sucesivos se estiman las perturbaciones a intervalos sucesivos <span class="hlt">por</span> un método determinístico. Para ilustrar el método y comprobar la precisión de nuestros resultados hemos simulado dos ejemplos incluyendo valores conocidos de las perturbaciones que luego comparamos con los resultados de nuestro método. El método puede aplicarse <span class="hlt">por</span> ejemplo para el intervalo de una revolución satelital lo cual permitiría el diseño inmediato de una maniobra correctiva de la órbita satelital.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.fs.usda.gov/treesearch/pubs/30560','TREESEARCH'); return false;" href="https://www.fs.usda.gov/treesearch/pubs/30560"><span>El Estado de los Bosques de Puerto Rico, 2003</span></a></p> <p><a target="_blank" href="http://www.fs.usda.gov/treesearch/">Treesearch</a></p> <p>Thomas J. Brandeis; Eileen H. Helmer; Sonja N. Oswalt</p> <p>2003-01-01</p> <p>La cobertura forestal de Puerto Rico sigue aumentando y ahora asciende a un 57 <span class="hlt">por</span> ciento en la isla de Puerto Rico, 85 <span class="hlt">por</span> ciento en Vieques y 88 <span class="hlt">por</span> ciento en Culebra. Los bosques subtropicales secos ocupan 50 346 ha, 6832 ha, 2591 ha y 6217 ha en las islas de Puerto Rico, Vieques, Culebra y Mona, respectivamente. El bosque subtropical húmedo, la zona de vida...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25460173','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25460173"><span>"Power-on resets" in cardiac implantable electronic devices during magnetic resonance imaging.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Higgins, John V; Sheldon, Seth H; Watson, Robert E; Dalzell, Connie; Acker, Nancy; Cha, Yong-Mei; Asirvatham, Samuel J; Kapa, Suraj; Felmlee, Joel P; Friedman, Paul A</p> <p>2015-03-01</p> <p>Magnetic resonance imaging (MRI) has been safely performed in some patients with cardiac implantable electronic devices (CIEDs) under careful monitoring and prespecified conditions. Pacemaker-dependent patients are often excluded, partly because of the potential for "power-on reset" (<span class="hlt">PoR</span>), which can lead to a change from asynchronous to inhibited pacing with consequent inhibition of pacing due to electromagnetic interference during MRI. The purpose of this study was to review risk factors for <span class="hlt">PoR</span> during MRI. A prospective study was performed between January 2008 and May 2013 in patients with CIEDs undergoing clinically indicated MRI. Eligible patients were not pacemaker dependent. Devices were interrogated before and after MRI, programmed to an asynchronous mode or an inhibition mode with tachyarrhythmia therapies turned off, and reprogrammed to their original settings after MRI. MRI scans (n = 256) were performed in 198 patients with non-MRI-conditional CIEDs between 2008 and 2013 (median age 66 years; interquartile range 57-77 years; 59% men). <span class="hlt">PoR</span> occurred during 9 MRI scans (3.5%) in 8 patients. <span class="hlt">PoR</span> was more frequent with Medtronic devices than with other generator brands (n = 9/139 vs 0/117 [6% vs 0%]; P = .005). Devices with <span class="hlt">PoR</span> were all released before 2002 and were implanted from 1999 to 2004. Effects of <span class="hlt">PoR</span> included a decrease in heart rate during MRI (n = 4) and transient anomalous battery life indication (n = 1). All devices functioned normally after MRI. <span class="hlt">PoR</span> occurs infrequently but can cause deleterious changes in pacing mode and heart rate. MRI should not be performed in pacemaker-dependent patients with older at-risk generators. Continuous monitoring during MRI is essential because unrecognized <span class="hlt">PoR</span> may inhibit pacing or accelerate battery depletion due to high pacing output. Copyright © 2015 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015EGUGA..17.2511R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015EGUGA..17.2511R"><span>Evaluating topographic effects on ground deformation: Insights from finite element modeling</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ronchin, Erika; Geyer, Adelina; Marti, Joan</p> <p>2015-04-01</p> <p>Ground deformation has been demonstrated to be one of the most common signals of volcanic unrest. Although volcanoes are commonly associated with significant topographic relief, most analytical models assumed the Earth's surface as flat. In the last years, it has been confirmed that this approximation can lead to important misinterpretations of the recorded surface deformation data. Here we perform a systematic and quantitative analysis of how topography may influence ground deformation signals and how these variations correlate with the different topographic parameters characterizing the terrain form (e.g. slope, aspect, curvature, etc.). For this, we bring together the results exposed in previous published papers and complement them with new axisymmetric and 3D Finite Elements (FE) models results. First, we study, in a parametric way, the influence of a volcanic edifice centered above the pressure source axis. Second, we carry out new 3D FE models simulating the real topography of three different volcanic areas representative of topographic scenarios common in volcanic regions: Rabaul caldera (Papua New Guinea) and the volcanic islands of Tenerife and El <span class="hlt">Hierro</span> (Canary Islands). The calculated differences are then correlated with a series of topographic parameters. The final aim is to investigate the artifacts that might arise from the use of half-space models at volcanic areas considering their diverse topographic features (e.g. collapse caldera structures, prominent central edifices, large landslide scars, etc.). Final conclusions may be also useful for the design of an optimal geodetic monitoring network. This research was partially funded by the European Commission (FP7 Theme: ENV.2011.1.3.3-1; Grant 282759: "VUELCO")and RYC-2012-11024.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012epsc.conf..292A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012epsc.conf..292A"><span>Iberian Pyrite Belt Subsurface Life (IPBSL), a drilling project in a geochemical Mars terrestrial analogue</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Amils, R.; Fernández-Remolar, D. C.; Parro, V.; Manfredi, J. A.; Timmis, K.; Oggerin, M.; Sánchez-Román, M.; López, F. J.; Fernández, J. P.; Omoregie, E.; Gómez-Ortiz, D.; Briones, C.; Gómez, F.; García, M.; Rodríguez, N.; Sanz, J. L.</p> <p>2012-09-01</p> <p>Iberian Pyrite Belt Subsurface Life (IPBSL) is a drilling project specifically designed to characterize the subsurface ecosystems operating in the Iberian Pyrite Belt (IPB), in the area of Peña de <span class="hlt">Hierro</span>, and responsible of the extreme acidic conditions existing in the Rio Tinto basin [1]. Rio Tinto is considered a good geochemical terrestrial analogue of Mars [2, 3]. A dedicated geophysical characterization of the area selected two drilling sites (4) due to the possible existence of water with high ionic content (low resistivity). Two wells have been drilled in the selected area, BH11 and BH10, of depths of 340 and 620 meters respectively, with recovery of cores and generation of samples in anaerobic and sterile conditions. Preliminary results showed an important alteration of mineral structures associated with the presence of water, with production of expected products from the bacterial oxidation of pyrite (sulfates and ferric iron). Ion chromatography of water soluble compounds from uncontaminated samples showed the existence of putative electron donors (ferrous iron, nitrite in addition of the metal sulfides), electron acceptors (sulfate, nitrate, ferric iron) as well as variable concentration of metabolic organic acids (mainly acetate, formate, propionate and oxalate), which are strong signals of the presence of active subsurface ecosystem associated to the high sulfidic mineral content of the IPB. The system is driven by oxidants that appear to be provided by the rock matrix, only groundwater is needed to launch microbial metabolism. The geological, geomicrobiological and molecular biology analysis which are under way, should allow the characterization of this ecosystem of paramount interest in the design of an astrobiological underground Mars exploration mission in the near future.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014E%26PSL.391...36G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014E%26PSL.391...36G"><span>Identification of the subsurface sulfide bodies responsible for acidity in Río Tinto source water, Spain</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gómez-Ortiz, David; Fernández-Remolar, David C.; Granda, Ángel; Quesada, Cecilio; Granda, Teresa; Prieto-Ballesteros, Olga; Molina, Antonio; Amils, Ricardo</p> <p>2014-04-01</p> <p>The acidic waters of the Río Tinto rise from several acidic springs that emerge in the area surrounding Peña de <span class="hlt">Hierro</span> (Fernández-Remolar et al., 2005). These springs are located above minor normal faults that act as natural conduits for the water from the underlying deep aquifer. Although it has been suggested that the acidity of the river originates from the biooxidation of massive and stockwork sulfides (Fernández-Remolar et al., 2008a), the location of the source for these acidic solutions has not previously been established. This lack of evidence has been used to suggest that the acidity of the Río Tinto may be the product of the most conspicuous of the possible source, the extensive mining of the area over approximately the last 5000 years (Davis et al., 2000). In this paper, we report resistivity and time-domain electromagnetic sounding data from the Río Tinto aquifer to a depth of ∼600 m, revealing the locations for the acidic sources. Both types of data support the presence of two distinct geological units that we interpret as thrust sheets emplaced onto each other during the Variscan orogeny of the Carboniferous. These units, both of which contain massive and stockwork sulfides, act as the aquifer for the acidic waters of the Río Tinto. Under this scenario, which is in agreement with the geological record of the Río Tinto fluvial system for the past 6 Ma (Moreno et al., 2003), our results imply that mining activity had little influence on the generation of the acidic river waters.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/14523525','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/14523525"><span>Complex population genetic structure in the endemic Canary Island pine revealed using chloroplast microsatellite markers.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Gómez, A; González-Martínez, S C; Collada, C; Climent, J; Gil, L</p> <p>2003-10-01</p> <p>The Canary archipelago, located on the northwestern Atlantic coast of Africa, is comprised of seven islands aligned from east to west, plus seven minor islets. All the islands were formed by volcanic eruptions and their geological history is well documented providing a historical framework to study colonization events. The Canary Island pine ( Pinus canariensis C. Sm.), nowadays restricted to the westernmost Canary Islands (Gran Canaria, Tenerife, La Gomera, La Palma and El <span class="hlt">Hierro</span>), is considered an old (Lower Cretaceous) relic from an ancient Mediterranean evolutionary centre. Twenty seven chloroplast haplotypes were found in Canary Island pine but only one of them was common to all populations. The distribution of haplotypic variation in P. canariensis suggested the colonization of western Canary Islands from a single continental source located close to the Mediterranean Basin. Present-day populations of Canary Island pine retain levels of genetic diversity equivalent to those found in Mediterranean continental pine species, Pinus pinaster and Pinus halepensis. A hierarchical analysis of variance (AMOVA) showed high differentiation among populations within islands (approximately 19%) but no differentiation among islands. Simple differentiation models such as isolation by distance or stepping-stone colonization from older to younger islands were rejected based on product-moment correlations between pairwise genetic distances and both geographic distances and population-age divergences. However, the distribution of cpSSR diversity within the islands of Tenerife and Gran Canaria pointed towards the importance of the role played by regional Pliocene and Quaternary volcanic activity and long-distance gene flow in shaping the population genetic structure of the Canary Island pine. Therefore, conservation strategies at the population level are strongly recommended for this species.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23465877','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23465877"><span>Lung transplant of extrahospitalary donor after cardiac death.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mateos Rodríguez, Alonso A; Navalpotro Pascual, José Maria; del Río Gallegos, Francisco</p> <p>2013-04-01</p> <p>Non-heart-beating donors (NHBDs) have to meet the predefined criteria for organ donation including death from irreversible cessation of the beating heart. The Maastricht conference defined 4 NHBD categories to differentiate their viability and ethical-legal support. In Spain, NHBDs who originate from an out-of-hospital setting correspond to type II donors. These are patients who have had a cardiac arrest outside hospital and, after failed CPR attempts, are transferred with hemodynamic support measures to the hospital for organ donation. The Hospital Clínico San Carlos also has a lung donation program in collaboration with the Hospital Puerta de <span class="hlt">Hierro</span> in Madrid and the Hospital Marques de Valdecilla in Santander. The objective of this study is to describe the results of lung transplantation of after cardiac death program, specifically the section regarding lung extraction donation. Twenty potential lung donors were obtained during the study. Most patients were male (19 cases), with a mean age of 42 years (36.5-49.5 years). A total of 33 lungs were donated (18 right and 15 left lungs). Most extractions were multiorganic (19 cases). One liver, 19 kidneys, 2 pancreas, and 19 corneas were obtained from these donors; bone tissue was obtained from all donors. The transplantation was bipulmonary in 13 cases and unipulmonary in 7. Thirty days after transplantation, 2 recipients died, 1 died of stroke associated with bilateral pneumonia and 1 died of hypovolemic shock resulting from hemothorax. The remaining 18 patients were progressing well at 30 days. Our data suggest that lung transplantation from patients after extrahospitalary cardiac death is feasible. Copyright © 2013 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25875193','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25875193"><span>Segmentation and tracking of anticyclonic eddies during a submarine volcanic eruption using ocean colour imagery.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Marcello, Javier; Eugenio, Francisco; Estrada-Allis, Sheila; Sangrà, Pablo</p> <p>2015-04-14</p> <p>The eruptive phase of a submarine volcano located 2 km away from the southern coast of El <span class="hlt">Hierro</span> Island started on October 2011. This extraordinary event provoked a dramatic perturbation of the water column. In order to understand and quantify the environmental impacts caused, a regular multidisciplinary monitoring was carried out using remote sensing sensors. In this context, we performed the systematic processing of every MODIS and MERIS and selected high resolution Worldview-2 imagery to provide information on the concentration of a number of biological, physical and chemical parameters. On the other hand, the eruption provided an exceptional source of tracer that allowed the study a variety of oceanographic structures. Specifically, the Canary Islands belong to a very active zone of long-lived eddies. Such structures are usually monitored using sea level anomaly fields. However these products have coarse spatial resolution and they are not suitable to perform submesoscale studies. Thanks to the volcanic tracer, detailed studies were undertaken with ocean colour imagery allowing, using the diffuse attenuation coefficient, to monitor the process of filamentation and axisymmetrization predicted by theoretical studies and numerical modelling. In our work, a novel 2-step segmentation methodology has been developed. The approach incorporates different segmentation algorithms and region growing techniques. In particular, the first step obtains an initial eddy segmentation using thresholding or clustering methods and, next, the fine detail is achieved by the iterative identification of the points to grow and the subsequent application of watershed or thresholding strategies. The methodology has demonstrated an excellent performance and robustness and it has proven to properly capture the eddy and its filaments.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_18 --> <div id="page_19" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="361"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28742841','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28742841"><span>Bacillus sp. JR3 esterase LipJ: A new mesophilic enzyme showing traces of a thermophilic past.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ribera, Judit; Estupiñán, Mónica; Fuentes, Alba; Fillat, Amanda; Martínez, Josefina; Diaz, Pilar</p> <p>2017-01-01</p> <p>A search for extremophile enzymes from ancient volcanic soils in El <span class="hlt">Hierro</span> Island (Canary Islands, Spain) allowed isolation of a microbial sporulated strain collection from which several enzymatic activities were tested. Isolates were obtained after sample cultivation under several conditions of nutrient contents and temperature. Among the bacterial isolates, supernatants from the strain designated JR3 displayed high esterase activity at temperatures ranging from 30 to 100°C, suggesting the presence of at least a hyper-thermophilic extracellular lipase. Sequence alignment of known thermophilic lipases allowed design of degenerated consensus primers for amplification and cloning of the corresponding lipase, named LipJ. However, the cloned enzyme displayed maximum activity at 30°C and pH 7, showing a different profile from that observed in supernatants of the parental strain. Sequence analysis of the cloned protein showed a pentapeptide motif -GHSMG- distinct from that of thermophilic lipases, and much closer to that of esterases. Nevertheless, the 3D structural model of LipJ displayed the same folding as that of thermophilic lipases, suggesting a common evolutionary origin. A phylogenetic study confirmed this possibility, positioning LipJ as a new member of the thermophilic family of bacterial lipases I.5. However, LipJ clusters in a clade close but separated from that of Geobacillus sp. thermophilic lipases. Comprehensive analysis of the cloned enzyme suggests a common origin of LipJ and other bacterial thermophilic lipases, and highlights the most probable divergent evolutionary pathway followed by LipJ, which during the harsh past times would have probably been a thermophilic enzyme, having lost these properties when the environment changed to more benign conditions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5526573','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5526573"><span>Bacillus sp. JR3 esterase LipJ: A new mesophilic enzyme showing traces of a thermophilic past</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ribera, Judit; Estupiñán, Mónica; Fuentes, Alba; Fillat, Amanda; Martínez, Josefina</p> <p>2017-01-01</p> <p>A search for extremophile enzymes from ancient volcanic soils in El <span class="hlt">Hierro</span> Island (Canary Islands, Spain) allowed isolation of a microbial sporulated strain collection from which several enzymatic activities were tested. Isolates were obtained after sample cultivation under several conditions of nutrient contents and temperature. Among the bacterial isolates, supernatants from the strain designated JR3 displayed high esterase activity at temperatures ranging from 30 to 100°C, suggesting the presence of at least a hyper-thermophilic extracellular lipase. Sequence alignment of known thermophilic lipases allowed design of degenerated consensus primers for amplification and cloning of the corresponding lipase, named LipJ. However, the cloned enzyme displayed maximum activity at 30°C and pH 7, showing a different profile from that observed in supernatants of the parental strain. Sequence analysis of the cloned protein showed a pentapeptide motif -GHSMG- distinct from that of thermophilic lipases, and much closer to that of esterases. Nevertheless, the 3D structural model of LipJ displayed the same folding as that of thermophilic lipases, suggesting a common evolutionary origin. A phylogenetic study confirmed this possibility, positioning LipJ as a new member of the thermophilic family of bacterial lipases I.5. However, LipJ clusters in a clade close but separated from that of Geobacillus sp. thermophilic lipases. Comprehensive analysis of the cloned enzyme suggests a common origin of LipJ and other bacterial thermophilic lipases, and highlights the most probable divergent evolutionary pathway followed by LipJ, which during the harsh past times would have probably been a thermophilic enzyme, having lost these properties when the environment changed to more benign conditions. PMID:28742841</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28767921','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28767921"><span>Hospitalization costs of severe bacterial pneumonia in children: comparative analysis considering different costing methods.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nunes, Sheila Elke Araujo; Minamisava, Ruth; Vieira, Maria Aparecida da Silva; Itria, Alexander; Pessoa, Vicente Porfirio; Andrade, Ana Lúcia Sampaio Sgambatti de; Toscano, Cristiana Maria</p> <p>2017-01-01</p> <p>To determine and compare hospitalization costs of bacterial community-acquired pneumonia cases via different costing methods under the Brazilian Public Unified Health System perspective. Cost-of-illness study based on primary data collected from a sample of 59 children aged between 28 days and 35 months and hospitalized due to bacterial pneumonia. Direct medical and non-medical costs were considered and three costing methods employed: micro-costing based on medical record review, micro-costing based on therapeutic guidelines and gross-costing based on the Brazilian Public Unified Health System reimbursement rates. Costs estimates obtained via different methods were compared using the Friedman test. Cost estimates of inpatient cases of severe pneumonia amounted to R$ 780,70/$Int. 858.7 (medical record review), R$ 641,90/$Int. 706.90 (therapeutic guidelines) and R$ 594,80/$Int. 654.28 (Brazilian Public Unified Health System reimbursement rates). Costs estimated via micro-costing (medical record review or therapeutic guidelines) did not differ significantly (p=0.405), while estimates based on reimbursement rates were significantly lower compared to estimates based on therapeutic guidelines (p<0.001) or record review (p=0.006). Brazilian Public Unified Health System costs estimated via different costing methods differ significantly, with gross-costing yielding lower cost estimates. Given costs estimated by different micro-costing methods are similar and costing methods based on therapeutic guidelines are easier to apply and less expensive, this method may be a valuable alternative for estimation of hospitalization costs of bacterial community-acquired pneumonia in children. Determinar e comparar custos hospitalares no tratamento da pneumonia bacteriana adquirida na comunidade <span class="hlt">por</span> diferentes metodologias de custeio, na perspectiva do Sistema Único de Saúde. Estudo de custo, com coleta de dados primários de uma amostra de 59 crianças com 28 dias a 35 meses de idade</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27718388','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27718388"><span>The role of galectin-1 in in vitro and in vivo photodynamic therapy with a galactodendritic porphyrin.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Pereira, Patrícia M R; Silva, Sandrina; Ramalho, José S; Gomes, Célia M; Girão, Henrique; Cavaleiro, José A S; Ribeiro, Carlos A F; Tomé, João P C; Fernandes, Rosa</p> <p>2016-11-01</p> <p>Conventional photodynamic agents used in clinic are porphyrin-based photosensitizers. However, they have low tumour selectivity, which may induce unwanted side-effects and damage to healthy tissues. In this study, we used a porphyrin with dendritic units of galactose (<span class="hlt">Por</span>Gal 8 ) developed by us, which can target the galactose-binding protein, galectin-1, known to be overexpressed in many tumour tissues. In vitro and in vivo studies had been conducted for the validation of <span class="hlt">Por</span>Gal 8 effectiveness. We showed a specific uptake of <span class="hlt">Por</span>Gal 8 and induction of apoptotic cell death by generating oxidative stress and alterations in the cytoskeleton of bladder cancer cells overexpressing galectin-1. We further validated the photodynamic efficiency of <span class="hlt">Por</span>Gal 8 in athymic nude mice (Balb/c nu/nu) bearing subcutaneously implanted luciferase-positive bladder cancer xenografts, overexpressing galectin-1 protein. <span class="hlt">Por</span>Gal 8 (5 μmol/kg, intraperitoneal), injected 24 h before light delivery (50.4 J/cm 2 ), inhibited tumour growth. We conclude that the use of <span class="hlt">Por</span>Gal 8 enables selective target and cytotoxicity by photodynamic therapy in cancer cells overexpressing galectin-1, preventing undesired phototoxicity in the surrounding healthy tissues. Copyright © 2016 Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/AD1026103','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/AD1026103"><span>Empirical Analysis of Using Erasure Coding in Outsourcing Data Storage With Provable Security</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2016-06-01</p> <p>the fastest encoding performance among the four tested schemes. We expected to observe that Cauchy Reed-Solomonwould be faster than Reed- Solomon for all...providing recoverability for <span class="hlt">POR</span>. We survey MDS codes and select Reed- Solomon and Cauchy Reed- Solomon MDS codes to be implemented into a prototype <span class="hlt">POR</span>...tools providing recoverability for <span class="hlt">POR</span>. We survey MDS codes and select Reed- Solomon and Cauchy Reed- Solomon MDS codes to be implemented into a</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27859887','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27859887"><span>Preclinical atherosclerosis at the time of pre-eclamptic pregnancy and up to 10 years postpartum: systematic review and meta-analysis.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Milic, N M; Milin-Lazovic, J; Weissgerber, T L; Trajkovic, G; White, W M; Garovic, V D</p> <p>2017-01-01</p> <p> Ltd. La preeclampsia (PE) es un trastorno hipertensivo específico del embarazo que ha sido asociada con factores de riesgo cardiovascular y cambios vasculares, tales como aterosis <span class="hlt">aguda</span> en los vasos sanguíneos de la placenta, similares a las primeras etapas de la aterosclerosis. El objetivo de este estudio fue determinar si las mujeres con PE han aumentado la carga aterosclerótica, según lo determinado <span class="hlt">por</span> el espesor del complejo íntima-media de la arteria carótida (CIMT, <span class="hlt">por</span> sus siglas en inglés), en comparación con las mujeres sin PE. MÉTODOS: Se realizó una revisión sistemática y un metaanálisis de estudios que reportaron el CIMT, una medida no invasiva de la aterosclerosis subclínica obtenida mediante ecografía, comparando mujeres con PE y mujeres sin ella. Solo se incluyeron estudios llevados a cabo durante el embarazo o durante la primera década después del parto, y en los que se midió el CIMT en la arteria carótida común. Se usaron las bases de datos de PubMed, EMBASE y Web of Science para identificar estudios publicados antes del 7 marzo de 2016. Dos revisores utilizaron formularios y protocolos preestablecidos para evaluar de forma independiente la elegibilidad de los estudios, a partir de los títulos y los resúmenes, y para realizar un cribado del texto completo, un resumen de los datos y una evaluación de calidad. La heterogeneidad se evaluó mediante el test estadístico I 2 . Se usó la diferencia de medias estandarizada (SMD, <span class="hlt">por</span> sus siglas en inglés) como una medida de la magnitud del efecto. En el metaanálisis se incluyeron catorce estudios. Siete de los estudios se llevaron a cabo durante embarazos complicados <span class="hlt">por</span> PE, 10 se realizaron hasta 10 años después del parto y tres incluyeron mediciones tomadas en ambos períodos. Las mujeres con PE tuvieron un CIMT significativamente mayor que aquellas que no la tenían, tanto en el momento del diagnóstico (SMD 1,10 (I 95%, 0,73-1,48), P <0,001) como en la primera década despu</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26854342','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26854342"><span>Co-infection of classic swine H1N1 influenza virus in pigs persistently infected with porcine rubulavirus.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rivera-Benitez, José Francisco; De la Luz-Armendáriz, Jazmín; Saavedra-Montañez, Manuel; Jasso-Escutia, Miguel Ángel; Sánchez-Betancourt, Ivan; Pérez-Torres, Armando; Reyes-Leyva, Julio; Hernández, Jesús; Martínez-Lara, Atalo; Ramírez-Mendoza, Humberto</p> <p>2016-02-29</p> <p>Porcine rubulavirus (<span class="hlt">Por</span>PV) and swine influenza virus infection causes respiratory disease in pigs. <span class="hlt">Por</span>PV persistent infection could facilitate the establishment of secondary infections. The aim of this study was to analyse the pathogenicity of classic swine H1N1 influenza virus (swH1N1) in growing pigs persistently infected with porcine rubulavirus. Conventional six-week-old pigs were intranasally inoculated with <span class="hlt">Por</span>PV, swH1N1, or <span class="hlt">Por</span>PV/swH1N1. A mock-infected group was included. The co-infection with swH1N1 was at 44 days post-infection (DPI), right after clinical signs of <span class="hlt">Por</span>PV infection had stopped. The pigs of the co-infection group presented an increase of clinical signs compared to the simple infection groups. In all infected groups, the most recurrent lung lesion was hyperplasia of the bronchiolar-associated lymphoid tissue and interstitial pneumonia. By means of immunohistochemical evaluation it was possible to demonstrate the presence of the two viral agents infecting simultaneously the bronchiolar epithelium. Viral excretion of <span class="hlt">Por</span>PV in nasal and oral fluid was recorded at 28 and 52 DPI, respectively. <span class="hlt">Por</span>PV persisted in several samples from respiratory tissues (RT), secondary lymphoid organs (SLO), and bronchoalveolar lavage fluid (BALF). For swH1N1, the viral excretion in nasal fluids was significantly higher in single-infected swH1N1 pigs than in the co-infected group. However, the co-infection group exhibited an increase in the presence of swH1N1 in RT, SLO, and BALF at two days after co-infection. In conclusion, the results obtained confirm an increase in the clinical signs of infection, and <span class="hlt">Por</span>PV was observed to impact the spread of swH1N1 in analysed tissues in the early stage of co-infection, although viral shedding was not enhanced. In the present study, the interaction of swH1N1 infection is demonstrated in pigs persistently infected with <span class="hlt">Por</span>PV. Copyright © 2016 Elsevier B.V. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://espanol.epa.gov/cai/monoxido-de-carbono','PESTICIDES'); return false;" href="https://espanol.epa.gov/cai/monoxido-de-carbono"><span>Monóxido de carbono</span></a></p> <p><a target="_blank" href="http://www.epa.gov/pesticides/search.htm">EPA Pesticide Factsheets</a></p> <p></p> <p></p> <p>La mayoria de los accidentes causados <span class="hlt">por</span> envenenamiento <span class="hlt">por</span> monoxido de carbono (CO) se producen en los hogares y estan relacionados a nuestras actividades diarias como cocinar y usar la calefaccion.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4662547','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4662547"><span>Genetic variations in NADPH-CYP450 oxidoreductase in a Czech Slavic cohort</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Tomková, Mária; Panda, Satya Prakash; Šeda, Ondřej; Baxová, Alice; Hůlková, Martina; Masters, Bettie Sue Siler; Martásek, Pavel</p> <p>2015-01-01</p> <p>Background Gene polymorphisms encoding the enzyme NADPH–cytochrome P450 oxidoreductase (<span class="hlt">POR</span>) contribute to inter-individual differences in drug response. Aim To estimate polymorphic allele frequencies of the <span class="hlt">POR</span> gene in a Czech Slavic population. Materials & Methods The gene <span class="hlt">POR</span> was analyzed in 322 Czech Slavic individuals from a control cohort by sequencing and HRM analysis. Results Twenty-five SNP genetic variations were identified. Of these variants, 7 were new, unreported SNPs, including two SNPs in the 5´flanking region (g.4965 C>T and g.4994 G>T), one intronic variant (c.1899 −20C>T), one synonymous SNP (p.20Ala=) and three nonsynonymous SNPs (p.Thr29Ser, p.Pro384Leu and p.Thr529Met). The p.Pro384Leu variant exhibited reduced enzymatic activities compared to wild type. Conclusion New <span class="hlt">POR</span> variant identification indicates that the number of uncommon variants might be specific for each subpopulation being investigated, particularly germane to the singular role that <span class="hlt">POR</span> plays in providing reducing equivalents to all CYPs in the endoplasmic reticulum. PMID:25712184</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22458916','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22458916"><span>Completing the surrogate motherhood process: parental order reporters' attitudes towards surrogacy arrangements, role ambiguity and role conflict.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Purewal, Satvinder; Crawshaw, Marilyn; van den Akker, Olga</p> <p>2012-06-01</p> <p>This study investigated the attitudes of parental order reporters (<span class="hlt">PORs</span>) towards their work with surrogacy arrangements and their experiences of role conflict and role ambiguity. A questionnaire was used to assess <span class="hlt">PORs</span>' perceptions of their role in parental order [PO] applications, attitudes towards surrogacy arrangements and the legal process and the influence of role ambiguity or conflict. Questionnaires were distributed to all <span class="hlt">PORs</span> employed by the Children and Family Court Advisory and Support Service in England. Thirty-three <span class="hlt">PORs</span> participated (response rate 46%) who, on average, had each completed five PO applications (range 1-40). Positive attitudes towards surrogacy and the child's needs for openness about origins were found. Concerns about the inadequacy of preparation and assessment arrangements, overseas arrangements and non-regulation of surrogacy agencies were evident. <span class="hlt">PORs</span> with high-role ambiguity were more likely to report less positive attitudes towards the emotional consequence of surrogacy on offspring. High scores on role ambiguity and role conflict were reflected in less positive attitudes towards the parties' preparation towards parenthood. These results have implications for training, policy and practice in this area.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28502901','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28502901"><span>Neuraminidase activity of blue eye disease porcine rubulavirus: Specificity, affinity and inhibition studies.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Santos-López, Gerardo; Borraz-Argüello, María T; Márquez-Domínguez, Luis; Flores-Alonso, Juan Carlos; Ramírez-Mendoza, Humberto; Priem, Bernard; Fort, Sébastien; Vallejo-Ruiz, Verónica; Reyes-Leyva, Julio; Herrera-Camacho, Irma</p> <p>2017-10-01</p> <p>Porcine rubulavirus (<span class="hlt">Por</span>PV), also known as La Piedad Michoacan Virus (LPMV) causes encephalitis and reproductive failure in newborn and adult pigs, respectively. The hemagglutinin-neuraminidase (HN) glycoprotein is the most exposed and antigenic of the virus proteins. HN plays central roles in <span class="hlt">Por</span>PV infection; i.e., it recognizes sialic acid-containing cell receptors that mediate virus attachment and penetration; in addition, its neuraminidase (sialic acid releasing) activity has been proposed as a virulence factor. This work describes the purification and characterization of <span class="hlt">Por</span>PV HN protein (isolate PAC1). The specificity of neuraminidase is restricted to sialyl(α2,3)lactose (3SL). HN showed typical Michaelis-Menten kinetics with fetuin as substrate (km=0.029μM, Vmax=522.8nmolmin -1 mg -1 ). When 3SL was used as substrate, typical cooperative kinetics were found (S 50 =0.15μM, Vmax=154.3nmolmin -1 mg -1 ). The influenza inhibitor zanamivir inhibited the <span class="hlt">Por</span>PV neuraminidase with IC 50 of 0.24μM. <span class="hlt">Por</span>PV neuraminidase was activated by Ca 2+ and inhibited by nucleoside triphosphates with the level of inhibition depending on phosphorylation level. The present results open possibilities to study the role of neuraminidase in the pathogenicity of <span class="hlt">Por</span>PV infection and its potential inhibitors. Copyright © 2017 Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3603759','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3603759"><span>Prevalence of asthma and chronic obstructive pulmonary disease in Aboriginal and non-Aboriginal populations: A systematic review and meta-analysis of epidemiological studies</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ospina, Maria B; Voaklander, Donald C; Stickland, Michael K; King, Malcolm; Senthilselvan, Ambikaipakan; Rowe, Brian H</p> <p>2012-01-01</p> <p>BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) have considerable potential for inequities in diagnosis and treatment, thereby affecting vulnerable groups. OBJECTIVE: To evaluate differences in asthma and COPD prevalence between adult Aboriginal and non-Aboriginal populations. METHODS: MEDLINE, EMBASE, specialized databases and the grey literature up to October 2011 were searched to identify epidemiological studies comparing asthma and COPD prevalence between Aboriginal and non-Aboriginal adult populations. Prevalence ORs (<span class="hlt">PORs</span>) and 95% CIs were calculated in a random-effects meta-analysis. RESULTS: Of 132 studies, eight contained relevant data. Aboriginal populations included Native Americans, Canadian Aboriginals, Australian Aboriginals and New Zealand Maori. Overall, Aboriginals were more likely to report having asthma than non-Aboriginals (<span class="hlt">POR</span> 1.41 [95% CI 1.23 to 1.60]), particularly among Canadian Aboriginals (<span class="hlt">POR</span> 1.80 [95% CI 1.68 to 1.93]), Native Americans (<span class="hlt">POR</span> 1.41 [95% CI 1.13 to 1.76]) and Maori (<span class="hlt">POR</span> 1.64 [95% CI 1.40 to 1.91]). Australian Aboriginals were less likely to report asthma (<span class="hlt">POR</span> 0.49 [95% CI 0.28 to 0.86]). Sex differences in asthma prevalence between Aboriginals and their non-Aboriginal counterparts were not identified. One study compared COPD prevalence between Native and non-Native Americans, with similar rates in both groups (<span class="hlt">POR</span> 1.08 [95% CI 0.81 to 1.44]). CONCLUSIONS: Differences in asthma prevalence between Aboriginal and non-Aboriginal populations exist in a variety of countries. Studies comparing COPD prevalence between Aboriginal and non-Aboriginal populations are scarce. Further investigation is needed to identify and account for factors associated with respiratory health inequalities among Aboriginal peoples. PMID:23248798</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5426571','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5426571"><span>Disconnection of the Perirhinal and Postrhinal Cortices Impairs Recognition of Objects in Context But Not Contextual Fear Conditioning</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2017-01-01</p> <p>The perirhinal cortex (PER) is known to process object information, whereas the rodent postrhinal cortex (<span class="hlt">POR</span>), homolog to the parahippocampal cortex in primates, is thought to process spatial information. A number of studies, however, provide evidence that both areas are involved in processing contextual information. In this study, we tested the hypothesis that the rat <span class="hlt">POR</span> relies on object information received from the PER to form complex representations of context. Using three fear-conditioning (FC) paradigms (signaled, unsignaled, and renewal) and two context-guided object recognition tasks (with 3D and 2D objects), we examined the effects of crossed excitotoxic lesions to the <span class="hlt">POR</span> and the contralateral PER. Performance of rats with crossed lesions was compared with that of rats with ipsilateral <span class="hlt">POR</span> plus PER lesions and sham-operated rats. We found that rats with contralateral PER–<span class="hlt">POR</span> lesions were impaired in object–context recognition but not in contextual FC. Therefore, interaction between the <span class="hlt">POR</span> and PER is necessary for context-guided exploratory behavior but not for associating fear with context. Our results provide evidence for the hypothesis that the <span class="hlt">POR</span> relies on object and pattern information from the PER to encode representations of context. The association of fear with a context, however, may be supported by alternate cortical and/or subcortical pathways when PER–<span class="hlt">POR</span> interaction is not available. Our results suggest that contextual FC may represent a special case of context-guided behavior. SIGNIFICANCE STATEMENT Representations of context are important for perception, memory, decision making, and other cognitive processes. Moreover, there is extensive evidence that the use of contextual representations to guide appropriate behavior is disrupted in neuropsychiatric and neurological disorders including developmental disorders, schizophrenia, affective disorders, and Alzheimer's disease. Many of these disorders are accompanied by changes in</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011GeCoA..75.7351H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011GeCoA..75.7351H"><span>Paleoenvironmental implications of taxonomic variation among δ 15 N values of chloropigments</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Higgins, Meytal B.; Wolfe-Simon, Felisa; Robinson, Rebecca S.; Qin, Yelun; Saito, Mak A.; Pearson, Ann</p> <p>2011-11-01</p> <p>Natural variations in the ratios of nitrogen isotopes in biomass reflect variations in nutrient sources utilized for growth. In order to use δ 15N values of chloropigments of photosynthetic organisms to determine the corresponding δ 15N values of biomass - and by extension, surface waters - the isotopic offset between chlorophyll and biomass must be constrained. Here we examine this offset in various geologically-relevant taxa, grown using nutrient sources that may approximate ocean conditions at different times in Earth's history. Phytoplankton in this study include cyanobacteria (diazotrophic and non-diazotrophic), eukaryotic algae (red and green), and anoxygenic photosynthetic bacteria (Proteobacteria), as well as environmental samples from sulfidic lake water. Cultures were grown using N 2, NO 3-, and NH 4+ as nitrogen sources, and were examined under different light regimes and growth conditions. We find surprisingly high variability in the isotopic difference (δ 15N biomass - δ 15N chloropigment) for prokaryotes, with average values for species ranging from -12.2‰ to +11.7‰. We define this difference as ɛ<span class="hlt">por</span>, a term that encompasses diagenetic porphyrins and chlorins, as well as chlorophyll. Negative values of ɛ<span class="hlt">por</span> reflect chloropigments that are 15N-enriched relative to biomass. Notably, this enrichment appears to occur only in cyanobacteria. The average value of ɛ<span class="hlt">por</span> for freshwater cyanobacterial species is -9.8 ± 1.8‰, while for marine cyanobacteria it is -0.9 ± 1.3‰. These isotopic effects group environmentally but not phylogenetically, e.g., ɛ<span class="hlt">por</span> values for freshwater Chroococcales resemble those of freshwater Nostocales but differ from those of marine Chroococcales. Our measured values of ɛ<span class="hlt">por</span> for eukaryotic algae (range = 4.7-8.7‰) are similar to previous reports for pure cultures. For all taxa studied, values of ɛ<span class="hlt">por</span> do not depend on the type of nitrogen substrate used for growth. The observed environmental control of ɛ<span class="hlt">por</span></p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28411272','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28411272"><span>Disconnection of the Perirhinal and Postrhinal Cortices Impairs Recognition of Objects in Context But Not Contextual Fear Conditioning.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Heimer-McGinn, Victoria R; Poeta, Devon L; Aghi, Krishan; Udawatta, Methma; Burwell, Rebecca D</p> <p>2017-05-03</p> <p>The perirhinal cortex (PER) is known to process object information, whereas the rodent postrhinal cortex (<span class="hlt">POR</span>), homolog to the parahippocampal cortex in primates, is thought to process spatial information. A number of studies, however, provide evidence that both areas are involved in processing contextual information. In this study, we tested the hypothesis that the rat <span class="hlt">POR</span> relies on object information received from the PER to form complex representations of context. Using three fear-conditioning (FC) paradigms (signaled, unsignaled, and renewal) and two context-guided object recognition tasks (with 3D and 2D objects), we examined the effects of crossed excitotoxic lesions to the <span class="hlt">POR</span> and the contralateral PER. Performance of rats with crossed lesions was compared with that of rats with ipsilateral <span class="hlt">POR</span> plus PER lesions and sham-operated rats. We found that rats with contralateral PER-<span class="hlt">POR</span> lesions were impaired in object-context recognition but not in contextual FC. Therefore, interaction between the <span class="hlt">POR</span> and PER is necessary for context-guided exploratory behavior but not for associating fear with context. Our results provide evidence for the hypothesis that the <span class="hlt">POR</span> relies on object and pattern information from the PER to encode representations of context. The association of fear with a context, however, may be supported by alternate cortical and/or subcortical pathways when PER-<span class="hlt">POR</span> interaction is not available. Our results suggest that contextual FC may represent a special case of context-guided behavior. SIGNIFICANCE STATEMENT Representations of context are important for perception, memory, decision making, and other cognitive processes. Moreover, there is extensive evidence that the use of contextual representations to guide appropriate behavior is disrupted in neuropsychiatric and neurological disorders including developmental disorders, schizophrenia, affective disorders, and Alzheimer's disease. Many of these disorders are accompanied by changes in</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JPhCS.945a2001A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JPhCS.945a2001A"><span>Porous silicon for drug delivery systems</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Abramova, E. N.; Khort, A. M.; Yakovenko, A. G.; Kornilova, D. S.; Slipchenko, E. A.; Prokhorov, D. I.; Shvets, V. I.</p> <p>2018-01-01</p> <p>The article deals with main principles of the formation of porous silicon (<span class="hlt">por</span>-Si) to produce containers for drug delivery systems. Most important <span class="hlt">por</span>-Si characteristics to produce nanocontainers with required parameters are determined.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/832509','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/832509"><span>Evolution of sensitivity to fosfomycin in bacteria isolated in 1973, 1974 and 1975 in the Servicio de Microbiologia y Epidemiologia of the 'Clinica Puerta de <span class="hlt">Hierro</span>', Madrid.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dámaso, D; Moreno-López, M; Martínez-Beltrán, J</p> <p>1977-01-01</p> <p>The bacteriostatic activity of fosfomycin was studied in vitro against 1,243 clinical isolations of gram-positive cocci and 4,086 isolations of gram-negative bacilli that were obtained in 1973, 1974 and in the period from January to May of 1975. MIC was determined by the agar diffusion method, quantifying it by means of the standard curve that was worked out with the strain of E. coli NCTC 10,418. A slight increase in resistance was observed in the gram-positive cocci: 64 mug/ml were inhibitory for 63% of the 249 isolations obtained in 1973, 59.1% of the 716 isolations obtained in 1974, and 57.5% of the 278 isolations from 1975. A slight loss of sensitivity was also observed in the gram-negative bacilli: the aforementioned concentration of fosfomycin inhibited 36% of the 742 isolations from 1973, 33.6% of the 2,387 isolations from 1974 and 32.6% of the 957 isolations from 1975. 933 g of this antibiotic were consumed in our hospital in 1973, 4,203 g in 1974 and 957 g in 1975. The consumption rate per patient per year was 0.15, 0.72 and 0.20 g, respectively. In conclusion, although no change was observed in the sensitivity of some bacterial strains to fosfomycin, the overall study indicates a slight decrease in the sensitivity, although it does not apparently have any relationship to the consumption of fosfomycin in our hospital.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2003cnam.conf...56M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2003cnam.conf...56M"><span>Moléculas orgánicas obtenidas en simulaciones experimentales del medio interestelar.</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Muñoz-Caro, Guillermo Manuel</p> <p></p> <p>Las nubes moleculares son regiones de formación de estrellas, con temperaturas cinéticas entre 10-50 K y densidades de 103-106 átomos cm-3. Su materia está formada <span class="hlt">por</span> gas y polvo interestelar. Estas partículas de polvo están cubiertas <span class="hlt">por</span> una fina capa de hielo, de unos 0.01 μm, que contiene H2O y a menudo CO, CO2, CH3OH y NH3. El hielo es presumiblemente irradiado <span class="hlt">por</span> fotones ultravioleta y rayos cósmicos en las zonas poco profundas de las nubes moleculares y las regiones circunestelares. En un sistema de vacío, P ˜ 10-7 mbar, simulamos la deposición de hielo a partir de 10 K y la irradiación ultravioleta <span class="hlt">por</span> medio de una lámpara de descarga de hidrógeno activada con microondas. La evolución del hielo se observa <span class="hlt">por</span> medio de un espectrómetro infrarrojo. De este modo es posible determinar la composición del hielo observado en el medio interestelar y predecir la presencia de moléculas aún no detectadas en el espacio, que han sido producto del procesamiento del hielo en nuestros experimentos. También es posible calentar el sistema hasta temperatura ambiente para sublimar el hielo depositado. Cuando el hielo ha sido previamente irradiado, se observa un residuo compuesto <span class="hlt">por</span> moléculas orgánicas complejas, algunas prebióticas, como varios ácidos carboxílicos, aminas, amidas, ésteres y en menor proporción moléculas heterocíclicas y aminoácidos. Algunas de estas moléculas podrían detectarse en estado gaseoso <span class="hlt">por</span> medio de observaciones milimétricas y de radio. También podrían estar presentes en el polvo cometario, cuyo análisis químico está planeado <span class="hlt">por</span> las misiones Stardust y Rosetta. Mientras tanto, nuestro grupo está llevando a cabo el análisis de partículas de polvo interplanetario (IDPs), algunas de las cuales pueden ser de origen cometario. Al igual que ocurre con los productos obtenidos <span class="hlt">por</span> irradiación del hielo en nuestros experimentos, algunas IDPs son ricas en material orgánico que contiene oxígeno.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29902138','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29902138"><span></span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Scotta, Ana Verónica; Bongiovanni, Guillermina Azucena; Soria, Elio Andrés</p> <p>2018-03-21</p> <p>Antecedentes: Clorpirifos es un pesticida altamente tóxico, que puede producir inmunotoxicidad con efectos deletéreos sobre la salud a nivel mundial. <span class="hlt">Por</span> otro lado, las plantas americanas pueden tener derivados con actividad protectora e inmunoestimulante. <span class="hlt">Por</span> lo tanto, debe evaluarse el potencial de estas plantas frente a clorpirifos. Objetivo: Identificar extractos acuosos bioactivos de Lantana grisebachii (LG), Aspidosperma quebracho-blanco (AQ), Peumus boldus (PB), e Ilex paraguariensis (IP), contra la toxicidad de clorpirifos sobre esplenocitos de hembras Balb/c. Materiales y Métodos: Esplenocitos fueron tratados in vitro <span class="hlt">por</span> 72 horas con 0-35 µg/mL de clorpirifos, 0-100 µg/mL de cada extracto (LG, AQ, PB, IP) y 0-5 µg/mL de concanavalina A. Luego, se midió y analizó estadísticamente viabilidad y muerte celular (tinciones de resazurina y yoduro de propidio), hidroperóxidos, lipoperóxidos (ensayos basados en naranja de xilenol), actividad de la ?-glutamiltranspeptidasa (método de Szasz). Resultados: Clorpirifos redujo la viabilidad celular de forma dosis dependiente, lo que fue contrarrestado <span class="hlt">por</span> AQ e IP, los que fueron menos activos en las células inducibles <span class="hlt">por</span> concanavalina A (p<0,05). La toxicidad <span class="hlt">por</span> clorpirifos implicó la inducción de la ?-glutamiltranspeptidasa con la consecuente reducción de los peróxidos, mientras que AQ y principalmente IP antagonizaron dichas respuestas (p<0,05). Conclusiones: Los extractos de Ilex paraguariensis y Aspidosperma quebracho-blanco protegieron in vitro a los esplenocitos frente a clorpirifos. Este efecto dependió del tipo celular, dado que las células inducibles <span class="hlt">por</span> concanavalina A fueron más susceptibles a este tóxico.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://rosap.ntl.bts.gov/view/dot/3187','DOTNTL'); return false;" href="https://rosap.ntl.bts.gov/view/dot/3187"><span>Sistemas de transporte inteligentes en cruces fronterizos internacionales : un estudio abarcador : facilitando el comercio y mejorando la seguridad en el transporte</span></a></p> <p><a target="_blank" href="http://ntlsearch.bts.gov/tris/index.do">DOT National Transportation Integrated Search</a></p> <p></p> <p>2001-04-01</p> <p>El Programa de Permisosen Fronteras Internacionales (IBC <span class="hlt">por</span> sus siglas en ingls) fue iniciado bajo la previsin del Acta de Eficiencia de Transporte Terrestre Intermodal (ISTEA <span class="hlt">por</span> sus siglas en ingls) en 1991. El programa fue concebido origina...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_19 --> <div id="page_20" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="381"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19423075','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19423075"><span>Evaluation of a 3year intervention to increase adoption of safer nursery crop production practices.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chapman, Larry J; Newenhouse, Astrid C; Karsh, Ben-Tzion</p> <p>2010-01-01</p> <p>We conducted a 3year intervention to increase awareness and adoption of eight more profitable nursery crop production practices that reduced certain traumatic and musculoskeletal injury hazards. We disseminated information to nursery managers across seven states using information channels they were known to rely on (e.g. trade publications, public events, university Extension, other managers). We evaluated rolling, independent, probability samples (n=1200) with mail questionnaires before the intervention and after each of 3 intervention years. We also evaluated samples (n=250) from a comparison group of New Zealand nursery managers. The intervention was associated with increased awareness of four of the eight practices among US managers after year 3 compared to their baseline: zippers (20 vs. 32%, <span class="hlt">p<or</span>=0.000), stools (11 vs. 22%, <span class="hlt">p<or</span>=0.001), pruners (29 vs. 40%, <span class="hlt">p<or</span>=0.014), and tarps (24 vs. 33%, <span class="hlt">p<or</span>=0.009). There were no changes in adoption. New Zealand manager awareness was increased for hoes after year 2 compared to their baseline (35 vs. 52%, <span class="hlt">p<or</span>=0.010). A modest, regionwide information dissemination intervention was associated with increased awareness, but not adoption.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1996BAAA...40...45O','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1996BAAA...40...45O"><span>Nuevos sistemas de frecuencia intermedia para el IAR</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Olalde, J. C.; Perilli, D.; Larrarte, J. J.</p> <p></p> <p>Se presenta el diagrama en bloques de los nuevos sistemas de Frecuencia Intermedia para los dos radiómetros instalados en el IAR. Entre las características más importantes del sistema podemos mencionar la posibilidad de conectar cualquiera de las dos antenas a los ``backend" disponibles: analizador espectral de alta resolución (META II) de 0,05 Hz, autocorrelador de 1008 canales y contínuo. Se incorporan al sistema nuevos sintetizadores de frecuencia implementados con PLL y la moderna técnica de síntesis digital directa. <span class="hlt">Por</span> último, el conjunto del sistema es susceptible de ser configurado <span class="hlt">por</span> las computadoras de adquisición de datos, supervisadas <span class="hlt">por</span> otra, que entrega el estado de funcionamiento actual y evita la selección de configuraciones incorrectas <span class="hlt">por</span> parte del usuario.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017JPhCS.917c2007Z','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017JPhCS.917c2007Z"><span>Novel approach for III-N on Si (111) templates fabrication by low-temperature PA MBE using porous Si layer</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zolotukhin, D.; Seredin, P.; Lenshin, A.; Goloshchapov, D.; Mizerov, A.</p> <p>2017-11-01</p> <p>We report on successful growth of GaN nanorods by low-temperature plasma-assisted molecular beam epitaxy on a Si(111) substrate with and without preformed thin porous Si layer (<span class="hlt">por</span>-Si). The deposited GaN initially forms islands which act as a seed for the wires. Porous structure of the <span class="hlt">por</span>-Si layer helps to control nucleation islands sizes and achieve homogeneous distribution of the nanorods diameters. In addition 850 nm-thick crack-free GaN layer was formed on Si(111) substrate with preformed <span class="hlt">por</span>-Si layer.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5242337','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5242337"><span>Microbicidas Metodo de Prevencion en VIH/SIDA Controlado <span class="hlt">por</span> Mujeres</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ruiz, Cindy; Torres, Viviana; Cianelli, Rosina; Ferrer, Lilian</p> <p>2016-01-01</p> <p>HIV/AIDS continues to expand throughout the world, and in recent times has had a severe impact on the number of women living with HIV. Access to methods of prevention for HIV/AIDS around the world is limited and for many women may not be feasible. Examples of such methods are sexual abstinence, which though recognized as an effective method of prevention is difficult for many women to achieve. Mutual fidelity is another option, but many women cannot control the sexual behavior of their partners. Finally, the male condom continues to be an available method of HIV prevention for sexually active people. However, in many places, gender inequality, social norms, and economic disparities severely limit women's capacity to negotiate the use of a condom with their partner. For this reason, an urgent need exists to develop a product for the prevention of HIV/AIDS that can be handled by women. Microbicides, products that can reduce HIV risk when applied intravaginally, hold promise for stopping the advance of HIV/AIDS, especially when considering that women can make their own decisions about whether to use them when other methods of prevention are not available. The objective of the current literature review was to understand the scientific advances related to microbicides in the prevention of HIV/AIDS in women through the analysis of available literature in this area. Interest in this topic emerged from the need to contribute to women's health and HIV/AIDS prevention. To achieve this review's objective, a search was carried out in multiple databases, including OVID, PUBMED, PROQUEST, and CINAHL, as well as published materials from organizations related to this area such as UNAIDS and CONASIDA, and literature available from the Internet. Upon completion of the literature review, it was concluded that microbicides are an effective method for preventing HIV/AIDS for women as well as their partners. Although they have a high level of acceptance among the female population, the majority of microbicides are still in clinical studies, requiring further evaluation for their safe use in humans. There are 3 microbicides in the final phases of clinical studies that will soon be available on the market. One of these was found to be 60% effective in protecting against the transmission of HIV and was used by women in 50% of their sexual activity, which resulted in avoiding approximately 2.5 million new HIV infections in men, women, and children over a 3-year period. PMID:28111528</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28111528','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28111528"><span>Microbicidas Metodo de Prevencion en VIH/SIDA Controlado <span class="hlt">por</span> Mujeres.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ruiz, Cindy; Torres, Viviana; Cianelli, Rosina; Ferrer, Lilian</p> <p>2009-03-01</p> <p>HIV/AIDS continues to expand throughout the world, and in recent times has had a severe impact on the number of women living with HIV. Access to methods of prevention for HIV/AIDS around the world is limited and for many women may not be feasible. Examples of such methods are sexual abstinence, which though recognized as an effective method of prevention is difficult for many women to achieve. Mutual fidelity is another option, but many women cannot control the sexual behavior of their partners. Finally, the male condom continues to be an available method of HIV prevention for sexually active people. However, in many places, gender inequality, social norms, and economic disparities severely limit women's capacity to negotiate the use of a condom with their partner. For this reason, an urgent need exists to develop a product for the prevention of HIV/AIDS that can be handled by women. Microbicides, products that can reduce HIV risk when applied intravaginally, hold promise for stopping the advance of HIV/AIDS, especially when considering that women can make their own decisions about whether to use them when other methods of prevention are not available. The objective of the current literature review was to understand the scientific advances related to microbicides in the prevention of HIV/AIDS in women through the analysis of available literature in this area. Interest in this topic emerged from the need to contribute to women's health and HIV/AIDS prevention. To achieve this review's objective, a search was carried out in multiple databases, including OVID, PUBMED, PROQUEST, and CINAHL, as well as published materials from organizations related to this area such as UNAIDS and CONASIDA, and literature available from the Internet. Upon completion of the literature review, it was concluded that microbicides are an effective method for preventing HIV/AIDS for women as well as their partners. Although they have a high level of acceptance among the female population, the majority of microbicides are still in clinical studies, requiring further evaluation for their safe use in humans. There are 3 microbicides in the final phases of clinical studies that will soon be available on the market. One of these was found to be 60% effective in protecting against the transmission of HIV and was used by women in 50% of their sexual activity, which resulted in avoiding approximately 2.5 million new HIV infections in men, women, and children over a 3-year period.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA539843','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA539843"><span>Decade of Venezuela’s President Hugo Chavez, <span class="hlt">Por</span> Ahora</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2009-04-01</p> <p>minor production source of opium and cocoa , Venezuela is important in the transit of narcotics between Columbia and the US. 60 61 Mindful of this, a...took over.91 To highlight the significance of oil to Venezuela , in 2006, oil represented 91% of its exports compared to 80% five years earlier.92...methodology to examine the last ten years of Venezuelas Hugo Chavez presidency and the significant aspects in terms of US security. The paper contents</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=passive+AND+house&id=EJ181762','ERIC'); return false;" href="https://eric.ed.gov/?q=passive+AND+house&id=EJ181762"><span>On the Use of "<span class="hlt">Por</span>" Plus Agent with "Se" Construction</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>De Mello, George</p> <p>1978-01-01</p> <p>Two explanations for the role of "se" in such constructions as "Se construyen casas" are given by grammarians; one states that it is a passive interpretation ("Houses are built"), the other advocates an impersonal interpretation ("One builds houses"). Different views are presented and analyzed. (Author/NCR)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017MS%26E..245g2030G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017MS%26E..245g2030G"><span>Spatial Tourist and Functional Diversity on the Volcanic Island of Gran Canaria</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gonda-Soroczyńska, Eleonora; Olczyk, Hanna</p> <p>2017-10-01</p> <p>The conducted research is focused on spatial, functional and landscape diversity, the existing tourist potential and the possibilities for further development of a small, volcanic island of Gran Canaria. The discussed island was compared against other islands of the Canarian archipelago (Lanzarote, Fuerteventura, Tenerife, La Palma, El <span class="hlt">Hierro</span>). Similarly to the remaining Canary Islands, the economy of Gran Canaria is predominantly based on tourism (approx. 4,5-5,0 million tourists visit the Canary Island annually and approx. 2,8 million come to Gran Canaria). Additionally, Puerto de la Luz transhipment centre in Las Palmas plays a very important role because of the goods imported from overseas. It is one of the largest ports in Spain (it reloads almost 2 million containers per year) also being an important Atlantic refuelling station. Apart from tourism, an important role is played here by agriculture, primarily the cultivation of bananas and tomatoes, which represent the most significant export good of the archipelago. The conducted spatial research showed an extensive diversity. This situation is, to a great extent, influenced by the climate. The northern part is cooler and dominated by agriculture, whereas the southern one is much warmer and characterized by a well-developed tourism infrastructure. Site inspections performed out along the outer contour of the island resembling a circle. Numerous architectural and urban sketches, urban analyses and photographic documentation were made. Community surveys were carried out. For a researcher, it was extremely interesting to answer the questions whether Gran Canaria is different from the other Canary Islands, especially in the functional and landscape context, and if so what exactly these differences consist of. What is Gran Canaria in particular characterized by and what kind of role it plays in the economic sector of Spain?</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015AGUFM.G13B..02B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015AGUFM.G13B..02B"><span>InSAR Tropospheric Correction Methods: A Statistical Comparison over Different Regions</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bekaert, D. P.; Walters, R. J.; Wright, T. J.; Hooper, A. J.; Parker, D. J.</p> <p>2015-12-01</p> <p>Observing small magnitude surface displacements through InSAR is highly challenging, and requires advanced correction techniques to reduce noise. In fact, one of the largest obstacles facing the InSAR community is related to tropospheric noise correction. Spatial and temporal variations in temperature, pressure, and relative humidity result in a spatially-variable InSAR tropospheric signal, which masks smaller surface displacements due to tectonic or volcanic deformation. Correction methods applied today include those relying on weather model data, GNSS and/or spectrometer data. Unfortunately, these methods are often limited by the spatial and temporal resolution of the auxiliary data. Alternatively a correction can be estimated from the high-resolution interferometric phase by assuming a linear or a power-law relationship between the phase and topography. For these methods, the challenge lies in separating deformation from tropospheric signals. We will present results of a statistical comparison of the state-of-the-art tropospheric corrections estimated from spectrometer products (MERIS and MODIS), a low and high spatial-resolution weather model (ERA-I and WRF), and both the conventional linear and power-law empirical methods. We evaluate the correction capability over Southern Mexico, Italy, and El <span class="hlt">Hierro</span>, and investigate the impact of increasing cloud cover on the accuracy of the tropospheric delay estimation. We find that each method has its strengths and weaknesses, and suggest that further developments should aim to combine different correction methods. All the presented methods are included into our new open source software package called TRAIN - Toolbox for Reducing Atmospheric InSAR Noise (Bekaert et al., in review), which is available to the community Bekaert, D., R. Walters, T. Wright, A. Hooper, and D. Parker (in review), Statistical comparison of InSAR tropospheric correction techniques, Remote Sensing of Environment</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26801597','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26801597"><span>The impact of the climate on the epidemiology of Dirofilaria immitis in the pet population of the Canary Islands.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Montoya-Alonso, J A; Carretón, E; Morchón, R; Silveira-Viera, L; Falcón, Y; Simón, F</p> <p>2016-01-30</p> <p>Cardiopulmonary dirofilariosis (heartworm) is a zoonotic vector borne disease caused by Dirofilaria immitis which affects domestic dogs and cats. Two of the seven Canary Islands are historically hyperendemic areas of dirofilariosis, although no epidemiological study has ever been carried out which includes the other islands. The aim of the study was to complete the epidemiological status of cardiopulmonary dirofilariosis in the canine and feline population throughout all the Canary Islands. 1643 client-owned dogs and 707 client-owned cats were tested for D. immitis antigens (dogs), and anti-D. immitis and anti-Wolbachia antibodies (cats). The prevalence of canine dirofilariosis in the Canary Islands was 15.7%, and the seroprevalence of feline dirofilariosis was 18.1%. A remarkable disparity was found when evaluating the results by island separately, which ranged from from 0% in Lanzarote and El <span class="hlt">Hierro</span>, low prevalences and seroprevalences in Fuerteventura (1.8% and 2.5% in dogs and cats, respectively), to higher prevalences on the other 4 islands; ranging between 15.7% (dogs) and 14.3% (cats) in La Palma 22.5% (dogs) and 24.1% (cats) in Tenerife. In addition, prevalences and seroprevalences were very variable within each island, these differences being associated to local climate conditions. The distribution and prevalence of dirofilariosis in the Canary Islands is heterogeneous and related to climate, demographic factors and management of pets in the studied areas. Dirofilariosis remains hyperendemic in 4 of the 7 Islands. Since D. immitis is a zoonosis, veterinary and health authorities should be aware of the current prevalence and seroprevalence of animal dirofilariosis. The results show the need for awareness raising campaigns to promote the implementation of prophylactic measures in pets, in order to achieve a decrease in the prevalence of animal dirofilariosis in the Canary Islands. Copyright © 2015 Elsevier B.V. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12195729','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12195729"><span>Serum copper and zinc concentrations in a representative sample of the Canarian population.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Díaz Romero, Carlos; Henríquez Sánchez, Patricia; López Blanco, Félix; Rodríguez Rodríguez, Elena; Serra Majem, Lluis</p> <p>2002-01-01</p> <p>Serum copper (Cu) and zinc (Zn) concentrations of 395 individuals (187 males + 208 females) living in Canary Islands were determined by flame atomic absorption spectrometry. The mean copper and zinc concentrations were 1.10 +/- 0.25 mg/L and 1.16 +/- 0.52 mg/L respectively. Our data were similar to other data published in other Spanish regions. Individuals from Lanzarote presented a mean Cu and Zn concentrations higher (p < 0.05) than individuals from the rest of islands; Individuals from EL <span class="hlt">Hierro</span> showed the lowest (p < 0.05) mean Zn concentration. These differences could be attributed a differences in Cu and Zn contents of soil and/or differences in dietary habits of the populations. The mean serum Cu concentration in females was higher (p < 0.05) than in males, however serum Zn concentration did not vary with the sex of the subjects. No relation to socio-economic status and educational level were found with respect to the serum Cu and Zn concentrations. The serum Cu concentration varied with age of individuals, observing the highest (p < 0.05) Cu concentration in the 20-30 year old interval. A higher serum Cu concentration in females within 20-30 year old interval was observed. This could be due to a higher use of oral contraceptives or to the higher number of pregnancies. Boys (younger than 15) showed a decrease (p < 0.05) of the serum Cu concentration with age. The mean Zn concentrations in serum did not change (p > 0.05) among the different age intervals. No clear trends in the serum Cu and Zn concentrations were observed when drinking and smoking habits were considered. The increase of physical exercise reduced (p < 0.05) the serum Cu concentrations.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27936449','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27936449"><span>Methotrexate-treated ectopic pregnancy: beta human chorionic gonadotropin serum changes as a success predictor using a mathematical model validation.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kovaleva, Aleksandra; Irishina, Natalia; Pereira, Augusto; Cuesta-Guardiola, Tatiana; Ortiz-Quintana, Luis</p> <p>2017-03-01</p> <p>Surgical rescue of methotrexate-treated ectopic pregnancy is necessary when tubal rupture or medical therapy failure is detected during post-therapeutic monitoring. It is known that an increased beta human chorionic gonadotropin (β-hCG) concentration is the most important factor associated with treatment failure. Therefore, we suggested that relative changes in serum β-hCG could predict a successful result of medical treatment, leading to facilitation of the decision to forgo the prospect of possible surgical rescue. A retrospective observational study of 115 patients with an ectopic pregnancy who were treated with a single dosage protocol of 50mg/m 2 of methotrexate injected intramuscularly was performed at Puerta de <span class="hlt">Hierro</span> University Hospital and Gregorio Marañón University General Hospital. Standard statistical tests were applied in order to evaluate the relative changes in β-hCG concentration between the 1st and the 4th days following methotrexate injection. Methotrexate treatment has a 95% probability to be successful if the relative change of β-hCG from the 1st to the 4th day of monitoring is within the following interval: [-1.02; 0.15]. Moreover, if the values of β-hCG-relative change from 1st to 4th day of monitoring are within [0.54; 1.2], it assures a negative result of treatment with 95% probability. Therefore, the value 0.15 (15%) of β-hCG relative change can be considered a cut-off value for a positive result to treatment. Our data support that negative β-hCG relative changes on the 4th day of treatment likely predict a successful result of methotrexate therapy, with a cut-off point of 0.15. Expectant management should be carried out in these cases if no clinical indications of surgery are presented. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27986205','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27986205"><span>Costo- Efectividad Del Uso Profiláctico Del Factor Estimulante De Colonias De Granulocitos En Adultos Con Leucemia Linfoblástica <span class="hlt">Aguda</span> en Colombia.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Casadiego Rincón, Elkin Javier; Díaz Rojas, Jorge Augusto; Bermúdez, Carlos Daniel; Martínez, Víctor Prieto</p> <p>2016-12-01</p> <p>To assess the cost-effectiveness of prophylactic administration of Granulocyte Colony-Stimulating Factor (G-CSF) compared with no use of it, during the induction phase of chemotherapy in Adults with Acute Lymphoblastic Leukemia (ALL) in Colombia. A decision tree with a time horizon of 30 days was built under colombian health system perspective including only direct costs. The costs of procedures and medications were taken from official sources and an institution of national reference of oncology services. The safety and effectiveness data were taken from the literature and two Colombian cohorts with patients older than 15 years. The unit of outcome was the proportion of deaths avoided. Base-case results on a clinical trial indicate that using factor is a dominant strategy. The variable that most impacted the outcome was the incidence of febrile neutropenia. Considering a threshold of $22.228 USD in 80% of cases using factor was cost effective. However, the use of factor is not cost-effective for the country for incidences of febrile neutropenia > 48%. It was not possible to establish cost-effectiveness of pegfilgrastim because no information was found. As per Colombian data, the use of prophylactic factor under chemotherapeutic induction in adults with ALL, turns out to be not cost effective. The difference in the results suggests the need of a careful extrapolation of information from clinical trials (ideal world) for developing economic evaluations in Colombia. Copyright © 2016 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22521998','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22521998"><span>Time spent traveling in motor vehicles and its association with overweight and abdominal obesity in Colombian adults who do not own a car.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Flórez Pregonero, Alberto; Gómez, Luis Fernando; Parra, Diana C; Cohen, Daniel D; Arango Paternina, Carlos Mario; Lobelo, Felipe</p> <p>2012-06-01</p> <p>This study examined associations between time spent traveling in motor vehicles per week (TSTMV) and BMI and abdominal obesity (AO) among Colombian adults residing in urban areas who do not own car. Secondary data analysis of the 2005 National Nutrition Survey of Colombia was conducted. TSTMV was assessed using the long International Physical Activity Questionnaire. Body composition was measured in 7900 adults. Polytomous and binary logistic regressions were conducted, stratified by gender and adjusted for confounders, including physical activity (PA). Forty-two percent of participants were either overweight or obese according to their BMI, and 22.4% had AO. Males in the middle (10 to 149 min) and highest (>150 min) TSTMV tertiles were more likely to be overweight (<span class="hlt">POR</span>=1.58, 95% CI=1.13-2.21 and <span class="hlt">POR</span>=1.55, 95% CI=1.12-2.15 respectively, p-trend=0.012), obese (<span class="hlt">POR</span>=2.39, 95% CI=1.43-3.99 and <span class="hlt">POR</span>=1.93, 95% CI=1.22-3.08 respectively, p trend=0.019) and to have AO (<span class="hlt">POR</span>=1.81, 95% CI=1.18-2.78 and <span class="hlt">POR</span>=1.73, 95% CI=1.18-2.54 respectively, p-trend=0.009). Associations were not significant in females. TSTMV was positively associated with overweight and AO in adult Colombian males even after adjusting for PA. These findings highlight the potential deleterious health effects of sedentary behaviors such as prolonged traveling time, independently of having met PA recommendations. Copyright © 2012 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27571668','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27571668"><span>[Not Available].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>San Mauro Martin, Ismael; Mendive Dubourdieu, Paula; Paredes Barato, Víctor; Garicano Vilar, Elena</p> <p>2016-07-19</p> <p>Introducción: la tradición de la comida picante desempeña un papel muy importante en el gusto <span class="hlt">por</span> este tipo de comida y su tolerancia. Las preferencias alimentarias muestran influencia genética y ambiental.Objetivos: estudiar la tolerancia y el gusto <span class="hlt">por</span> el picante de tres poblaciones, y la influencia hereditaria y del ambiente.Métodos:se realizó una encuesta a 522 sujetos, de tres continentes (Asia, Europa y Latinoamérica) en tres idiomas (español, inglés y chino) a través de Internet. Se realizaron preguntas acerca de la tolerancia al picante, el gusto <span class="hlt">por</span> los alimentos picantes, su uso, la edad de comienzo de consumo, el gusto del padre y de la madre y si ella lo consumía durante el embarazo y/o lactancia.Resultados: existe diferencia entre el gusto <span class="hlt">por</span> el picante del hijo y el sexo (p < 0,001), la tolerancia (p < 0,001) y, solo en el sexo femenino, el gusto de la madre <span class="hlt">por</span> el picante (p < 0,001), su consumo durante el embarazo (p < 0,001) y la lactancia (p = 0,005) y el gusto del padre <span class="hlt">por</span> el picante (p = 0,003). Existe correlación entre el continente de residencia (p = 0,007) y de nacimiento (p = 0,012) y la tolerancia a los alimentos picantes.Conclusión: la influencia de los progenitores, el género y la composición corporal se relacionaron con gustos y tolerancias diferentes.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4958558','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4958558"><span>Sunburn and sun-protective behaviors among adults with and without previous nonmelanoma skin cancer: a population-based study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Fischer, Alexander H.; Wang, Timothy S.; Yenokyan, Gayane; Kang, Sewon; Chien, Anna L.</p> <p>2016-01-01</p> <p>Background Individuals with previous nonmelanoma skin cancer (NMSC) are at increased risk for subsequent skin cancer, and should therefore limit UV exposure. Objective To determine whether individuals with previous NMSC engage in better sun protection than those with no skin cancer history. Methods We pooled self-reported data (2005 and 2010 National Health Interview Surveys) from US non-Hispanic white adults (758 with and 34,161 without previous NMSC). We calculated adjusted prevalence odds ratios (a<span class="hlt">POR</span>) and 95% confidence intervals (95% CI), taking into account the complex survey design. Results Individuals with previous NMSC versus no history of NMSC had higher rates of frequent use of shade (44.3% versus 27.0%; a<span class="hlt">POR</span>=1.41; 1.16–1.71), long sleeves (20.5% versus 7.7%; a<span class="hlt">POR</span>=1.55; 1.21–1.98), a wide-brimmed hat (26.1% versus 10.5%; a<span class="hlt">POR</span>=1.52; 1.24–1.87), and sunscreen (53.7% versus 33.1%; a<span class="hlt">POR</span>=2.11; 95% CI=1.73–2.59), but did not have significantly lower odds of recent sunburn (29.7% versus 40.7%; a<span class="hlt">POR</span>=0.95; 0.77–1.17). Among subjects with previous NMSC, recent sunburn was inversely associated with age, sun avoidance, and shade but not sunscreen. Limitations Self-reported cross-sectional data and unavailable information quantifying regular sun exposure. Conclusion Physicians should emphasize sunburn prevention when counseling patients with previous NMSC, especially younger adults, focusing on shade and sun avoidance over sunscreen. PMID:27198078</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/9349847','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/9349847"><span>Factors associated with anemia in refugee children.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hassan, K; Sullivan, K M; Yip, R; Woodruff, B A</p> <p>1997-11-01</p> <p>A nutrition survey was performed in 1990 among children 6 through 35 mo of age living in Palestinian refugee camps in Syria, Jordan, the West Bank, Gaza Strip and Lebanon. Overall, 67% [95% confidence interval (CI): 66, 68] were anemic (hemoglobin <110 g/L), ranging from 54% in the West Bank to 75% in Syria. The following factors were significantly associated with anemia in one or more of three age groups (6-11.9, 12-23.9 and 24-35.9 mo) by logistic regression: living in Syria, Lebanon, or Gaza [with prevalence odds ratios (<span class="hlt">POR</span>) in the range of 1.4-2.6 depending on the age group and area, relative to children living in Jordan]; never having been breast-fed (<span class="hlt">POR</span> = 1.7); male sex (<span class="hlt">POR</span> = 1.2); maternal illiteracy (<span class="hlt">POR</span> = 1.4 relative to those with >/=6 y of education); having a recent (within 2 wk) or current episode of fever or diarrhea; and stunting. Recent or current illness and stunting interacted in two age groups with the general trend of stunted children with recent or current illness having high <span class="hlt">POR</span>. Early childhood anemia is associated with factors reflecting poor socioeconomic status and recent diarrheal and febrile illnesses in Palestinian refugee camps.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/15910618','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/15910618"><span>Risk of specific congenital abnormalities in offspring of women with diabetes.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nielsen, G L; Nørgard, B; Puho, E; Rothman, K J; Sørensen, H T; Czeizel, A E</p> <p>2005-06-01</p> <p>To assess the extent to which the increased risk of congenital abnormalities seen in women with pre-gestational insulin-treated diabetes mellitus is unspecific or related to the embryology of specific organs. Cases with congenital abnormalities were identified in the population-based Hungarian Congenital Abnormality Registry from 1980 to 1996 with two newborn children without congenital abnormality selected from the National Birth Registry as controls. We adjusted for parity, maternal age, and use of antipsychotic drugs. Among cases we found 63/22,843 babies with maternal diabetes compared with 50/38,151 in the control group [adjusted prevalence odds ratio (<span class="hlt">POR</span>) 2.1; 95% CI 1.5-3.1]. The association was strongest for the following congenital abnormalities: renal agenesis (<span class="hlt">POR</span>: 14.8; 95% CI, 3.5-62.1), obstructive congenital abnormalities of the urinary tract (<span class="hlt">POR</span>: 4.3; 95% CI, 1.3-13.9), cardiovascular congenital abnormalities (<span class="hlt">POR</span>: 3.4; 95% CI, 2.0-5.7), and multiple congenital abnormalities (<span class="hlt">POR</span>: 5.0; 95% CI, 2.4-10.2). These data indicate that pre-gestational maternal diabetes is associated with strong teratogenic effects on the kidney, urinary tract, and heart, and strongly associated with multiple congenital abnormalities. We found no material association between diabetes and spinal congenital abnormalities and limb deficiencies.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/publication/?seqNo115=283860','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/publication/?seqNo115=283860"><span>Using MOMP typing as an epidemiological tool to investigate outbreaks caused by milkborne Campylobacter jejuni isolates in California</span></a></p> <p><a target="_blank" href="https://www.ars.usda.gov/research/publications/find-a-publication/">USDA-ARS?s Scientific Manuscript database</a></p> <p></p> <p></p> <p>We describe using major outer membrane protein (MOMP) typing as a screen to compare the C. jejuni <span class="hlt">por</span>A gene sequences of clinical outbreak strains from human stool with the <span class="hlt">por</span>A sequences of dairy farm strains isolated during two milkborne campylobacteriosis outbreak investigations in California. Th...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://espanol.epa.gov/espanol/unidades-generadoras-de-energia-electrica-para-servicios-publicos-revocacion-del-plan-de','PESTICIDES'); return false;" href="https://espanol.epa.gov/espanol/unidades-generadoras-de-energia-electrica-para-servicios-publicos-revocacion-del-plan-de"><span>Unidades generadoras de energía eléctrica para servicios públicos: Revocación del Plan de Energía Limpia: Propuesta</span></a></p> <p><a target="_blank" href="http://www.epa.gov/pesticides/search.htm">EPA Pesticide Factsheets</a></p> <p></p> <p></p> <p>La EPA está proponiendo la revocación del Plan de Energía Limpia (CPP, <span class="hlt">por</span> sus siglas en inglés) – después de completar una revisión minuciosa como fue dictaminada <span class="hlt">por</span> la Orden Ejecutiva de Independencia Energética.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_20 --> <div id="page_21" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="401"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2013-05-20/pdf/2013-11968.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2013-05-20/pdf/2013-11968.pdf"><span>78 FR 29322 - Silicon Metal From the People's Republic of China: Final Results and Final No Shipments...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2013-05-20</p> <p>... People's Republic of China: Final Results and Final No Shipments Determination of Antidumping Duty... the People's Republic of China (``PRC'').\\1\\ The period of review (``<span class="hlt">POR</span>'') is June 1, 2011, through... any reviewable transactions during the <span class="hlt">POR</span>. \\1\\ See Silicon Metal From the People's Republic of China...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-05-15/pdf/2012-11771.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-05-15/pdf/2012-11771.pdf"><span>77 FR 28570 - Honey From Argentina: Extension of Time Limit for the Final Results of Antidumping Duty...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-05-15</p> <p>... DEPARTMENT OF COMMERCE International Trade Administration [A-357-812] Honey From Argentina... administrative review for the 2009-2010 period of review (<span class="hlt">POR</span>) of honey from Argentina. See Honey From Argentina... producers/exporters of honey from Argentina during the <span class="hlt">POR</span>.\\1\\ \\1\\ See Preliminary Results for a detailed...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2000BAAA...44Q...2P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2000BAAA...44Q...2P"><span>El nuevo panorama de la Dinámica Galáctica</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Pivovaroff, Michael James</p> <p></p> <p>En general, la tendencia imperante en Dinámica Galáctica ha sido considerar que los movimientos estelares son básicamente regulares y que el caos no tiene mayor relevancia en los sistemas estelares. Sin embargo, en el último lustro se vienen acumulando pruebas de la importancia del movimiento caótico en ciertos sistemas estelares que existen en la naturaleza. <span class="hlt">Por</span> una parte, sobre todo el grupo de David Merritt, lo ha mostrado en los casos de galaxias elípticas con concentraciones centrales de materia; <span class="hlt">por</span> otra parte, en nuestro propio grupo, lo hemos mostrado para el caso de los satélites galácticos. Las consecuencias de estos hallazgos son tanto de tipo técnico, <span class="hlt">por</span> la necesidad de construir modelos que contengan órbitas caóticas, como astrofísico, <span class="hlt">por</span> los efectos del caos sobre la estacionariedad y evolución de los sistemas estelares en los que se presenta.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25023856','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25023856"><span>Tyrosine oxidation in heme oxygenase: examination of long-range proton-coupled electron transfer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Smirnov, Valeriy V; Roth, Justine P</p> <p>2014-10-01</p> <p>Heme oxygenase is responsible for the degradation of a histidine-ligated ferric protoporphyrin IX (<span class="hlt">Por</span>) to biliverdin, CO, and the free ferrous ion. Described here are studies of tyrosyl radical formation reactions that occur after oxidizing Fe(III)(<span class="hlt">Por</span>) to Fe(IV)=O(<span class="hlt">Por</span>(·+)) in human heme oxygenase isoform-1 (hHO-1) and the structurally homologous protein from Corynebacterium diphtheriae (cdHO). Site-directed mutagenesis on hHO-1 probes the reduction of Fe(IV)=O(<span class="hlt">Por</span>(·+)) by tyrosine residues within 11 Å of the prosthetic group. In hHO-1, Y58· is implicated as the most likely site of oxidation, based on the pH and pD dependent kinetics. The absence of solvent deuterium isotope effects in basic solutions of hHO-1 and cdHO contrasts with the behavior of these proteins in the acidic solution, suggesting that long-range proton-coupled electron transfer predominates over electron transfer.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25712184','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25712184"><span>Genetic variations in NADPH-CYP450 oxidoreductase in a Czech Slavic cohort.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tomková, Mária; Panda, Satya Prakash; Šeda, Ondřej; Baxová, Alice; Hůlková, Martina; Siler Masters, Bettie Sue; Martásek, Pavel</p> <p>2015-01-01</p> <p>Estimating polymorphic allele frequencies of the NADPH-CYP450 oxidoreductase (<span class="hlt">POR</span>) gene in a Czech Slavic population. The <span class="hlt">POR</span> gene was analyzed in 322 individuals from a control cohort by sequencing and high resolution melting analysis. We identified seven unreported SNP genetic variations, including two SNPs in the 5' flanking region (g.4965C>T and g.4994G>T), one intronic variant (c.1899-20C>T), one synonymous SNP (p.20Ala=) and three nonsynonymous SNPs (p.Thr29Ser, p.Pro384Leu and p.Thr529Met). The p.Pro384Leu variant exhibited reduced enzymatic activities compared with wild-type. New <span class="hlt">POR</span> variant identification indicates the number of uncommon variants might be specific for each subpopulation being investigated, particularly germane to the singular role that <span class="hlt">POR</span> plays in providing reducing equivalents to all CYP450s in the endoplasmic reticulum. Original submitted 15 September 2014; Revision submitted 17 November 2014.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28572737','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28572737"><span>Observational study to calculate addictive risk to opioids: a validation study of a predictive algorithm to evaluate opioid use disorder.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Brenton, Ashley; Richeimer, Steven; Sharma, Maneesh; Lee, Chee; Kantorovich, Svetlana; Blanchard, John; Meshkin, Brian</p> <p>2017-01-01</p> <p>Opioid abuse in chronic pain patients is a major public health issue, with rapidly increasing addiction rates and deaths from unintentional overdose more than quadrupling since 1999. This study seeks to determine the predictability of aberrant behavior to opioids using a comprehensive scoring algorithm incorporating phenotypic risk factors and neuroscience-associated single-nucleotide polymorphisms (SNPs). The Proove Opioid Risk (<span class="hlt">POR</span>) algorithm determines the predictability of aberrant behavior to opioids using a comprehensive scoring algorithm incorporating phenotypic risk factors and neuroscience-associated SNPs. In a validation study with 258 subjects with diagnosed opioid use disorder (OUD) and 650 controls who reported using opioids, the <span class="hlt">POR</span> successfully categorized patients at high and moderate risks of opioid misuse or abuse with 95.7% sensitivity. Regardless of changes in the prevalence of opioid misuse or abuse, the sensitivity of <span class="hlt">POR</span> remained >95%. The <span class="hlt">POR</span> correctly stratifies patients into low-, moderate-, and high-risk categories to appropriately identify patients at need for additional guidance, monitoring, or treatment changes.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29165933','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29165933"><span>Transmission scenarios of major vector-borne diseases in Colombia, 1990-2016.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Padilla, Julio César; Lizarazo, Fredy Eberto; Murillo, Olga Lucía; Mendigaña, Fernando Antonio; Pachón, Edwin; Vera, Mauricio Javier</p> <p>2017-03-29</p> <p>Introducción. Las enfermedades transmitidas <span class="hlt">por</span> vectores representan más de 17 % de todas las enfermedades infecciosas y causan anualmente un millón de defunciones a nivel mundial. En Colombia, la malaria, el dengue, la enfermedad de Chagas y las leishmaniasis son condiciones endemoepidémicas persistentes.Objetivo. Determinar el comportamiento epidemiológico de las enfermedades transmitidas <span class="hlt">por</span> vectores en zonas urbanas y rurales de Colombia entre 1990 y 2016.Materiales y métodos. Se hizo un estudio descriptivo del comportamiento epidemiológico de las principales enfermedades transmitidas <span class="hlt">por</span> vectores en zonas urbanas y rurales de Colombia entre 1990 y 2016, con la información proveniente de fuentes oficiales secundarias.Resultados. En el periodo estudiado se registraron 5'360.134 casos de enfermedades transmitidas <span class="hlt">por</span> vectores, de los cuales 54,7 % fueron de malaria y 24,9 % de dengue. Estos casos concentraron el 80 % de la carga acumulada de casos de enfermedades transmitidas <span class="hlt">por</span> vectores. Las medianas de las tasas de incidencia fueron 1.371 y 188 <span class="hlt">por</span> 100.00 habitantes para malaria y dengue, respectivamente. Además, los casos de chikungunya fueron 774.831 desde su introducción en el 2014 y, los de Zika, 117.674 desde su aparición en 2015. En las zonas rurales predominaron las enfermedades parasitarias transmitidas <span class="hlt">por</span> vectores como la malaria, las leishmaniasis y la enfermedad de Chagas. A nivel urbano, predominaron el dengue, el chikungunya y el Zika.Conclusiones. La transmisión en Colombia de estas enfermedades es persistente en las zonas urbanas y en las rurales, y de tipo endemoepidémico en los casos de malaria, dengue, leishmaniasis y enfermedad de Chagas. Dicha transmisión se ha dado de manera focalizada y con patrones variables de intensidad. Asimismo, se mantienen las condiciones que han favorecido la transmisión emergente de nuevas arbovirosis.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2011-05-06/pdf/2011-11119.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2011-05-06/pdf/2011-11119.pdf"><span>76 FR 26241 - Certain Frozen Warmwater Shrimp From Thailand: Notice of Court Decision Not in Harmony With Final...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2011-05-06</p> <p>... Shrimp From Thailand: Notice of Court Decision Not in Harmony With Final Results of Administrative Review... Thailand covering the period of review (<span class="hlt">POR</span>) of February 1, 2006, through January 31, 2007. DATES... administrative review of certain frozen warmwater shrimp from Thailand covering the <span class="hlt">POR</span> of February 1, 2006...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.epa.gov/caa-permitting/proyecto-energetico-palmdale-decision-del-permiso-final','PESTICIDES'); return false;" href="https://www.epa.gov/caa-permitting/proyecto-energetico-palmdale-decision-del-permiso-final"><span>Proyecto Energético Palmdale; Decisión del Permiso Final</span></a></p> <p><a target="_blank" href="http://www.epa.gov/pesticides/search.htm">EPA Pesticide Factsheets</a></p> <p></p> <p></p> <p>Proyecto Energético Palmdale: EPA Región 9 <span class="hlt">por</span> el presente emite aviso de su decisión final, el cumplimiento con la Ley Federal de Aire Limpio, para la construcción de una planta generadora de electricidad de ciclo combinado y alimentada <span class="hlt">por</span> gas natural</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28000482','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28000482"><span></span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Escandón-Nagel, Neli</p> <p>2016-11-29</p> <p>Introducción: si bien el Trastorno <span class="hlt">por</span> Atracón es un trastorno de la conducta alimentaria que  no se da exclusivamente en personas obesas, es más común en este grupo que en sujetos con normopeso, sin embargo no todas las personas con malnutrición <span class="hlt">por</span> exceso presentan Trastorno <span class="hlt">por</span> Atracón. Objetivo: identificar el conocimiento actual respecto a las diferencias y semejanzas existentes entre personas con malnutrición <span class="hlt">por</span> exceso con y sin Trastorno <span class="hlt">por</span> Atracón.Método: para lograr el objetivo anterior, se realizó una revisión de artículos científicos en torno al tema.Resultados: primero se analizó la comorbilidad psicopatológica en obesidad y después se detectaron similitudes y diferencias entre los grupos de interés, tanto en sintomatología general, como así también en sintomatología de la conducta alimentaria. Además, se identificaron algunos aspectos controversiales, en que existe evidencia contradictoria respecto a la comparación intergrupal.Conclusión: de esta revisión se concluye que en el estudio de la obesidad se hace necesario conocer en mayor profundidad las características del subgrupo de pacientes que además presenta Trastorno <span class="hlt">por</span> Atracón,  ya que estas personas poseen características distintivas cuyo conocimiento permitirá ofrecer tratamientos integrales más adecuados a las necesidades de los pacientes, lo que posibilitará, en consecuencia, diseñar intervenciones más eficaces.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27513493','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27513493"><span>[Not Available].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Latorre-Román, Pedro Ángel; Martínez-López, Emilio José; Ruiz-Ariza, Alberto; Izquierdo-Rus, Tomás; Salas-Sánchez, Jesús; García-Pinillos, Felipe</p> <p>2016-06-30</p> <p>Objetivo: el objetivo de este estudio es evaluar las propiedades psicométricas del cuestionario de disfrute <span class="hlt">por</span> el ejercicio físico (PACES) en adolescentes con sobrepeso y obesidad.Métodos: participaron 139 adolescentes con sobrepeso y obesidad: 91 niñas (edad = 13,85 ± 1,92 años; índice de masa corporal [IMC] = 26,83 ± 3,16 kg/m2) y 48 niños (edad = 14,29 ± 1,62 años; IMC = 28,31 ± 3,74 kg/m2). Para analizar el disfrute <span class="hlt">por</span> la actividad física se empleó el cuestionario Physical Activity Enjoyment Scale (PACES).Resultados: los resultados del análisis factorial exploratorio y confirmatorio han mostrado una estructura de dos factores; a su vez el PACES presenta una consistencia interna muy alta (alfa de Cronbach = 0,908). La fiabilidad test-retest indica una buena concordancia temporal (Spearman rho = 0,815, p < 0,001). <span class="hlt">Por</span> último, el PACES en adolescentes con sobrepeso y obesidad manifiesta una validez convergente adecuada con la intencionalidad de ser activo (MIFA), la atracción <span class="hlt">por</span> la actividad física (CAPA), la resistencia cardiorrespiratoria y los pliegues suprailiacoy subescapular.Conclusión: los resultados confirman que el PACES es una medida válida y fiable del disfrute <span class="hlt">por</span> la actividad física en adolescentes con sobrepeso y obesidad. El disfrute <span class="hlt">por</span> la actividad física puede ser relevante en la participación de los adolescentes con sobrepeso y obesidad en estas actividades.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5462053','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5462053"><span>LIL3, a Light-Harvesting Complex Protein, Links Terpenoid and Tetrapyrrole Biosynthesis in Arabidopsis thaliana1[OPEN</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Rothbart, Maxi; Herbst, Josephine; Wittmann, Daniel; Gruhl, Kirsten</p> <p>2017-01-01</p> <p>The LIL3 protein of Arabidopsis (Arabidopsis thaliana) belongs to the light-harvesting complex (LHC) protein family, which also includes the light-harvesting chlorophyll-binding proteins of photosystems I and II, the early-light-inducible proteins, PsbS involved in nonphotochemical quenching, and the one-helix proteins and their cyanobacterial homologs designated high-light-inducible proteins. Each member of this family is characterized by one or two LHC transmembrane domains (referred to as the LHC motif) to which potential functions such as chlorophyll binding, protein interaction, and integration of interacting partners into the plastid membranes have been attributed. Initially, LIL3 was shown to interact with geranylgeranyl reductase (CHLP), an enzyme of terpene biosynthesis that supplies the hydrocarbon chain for chlorophyll and tocopherol. Here, we show another function of LIL3 for the stability of protochlorophyllide oxidoreductase (<span class="hlt">POR</span>). Multiple protein-protein interaction analyses suggest the direct physical interaction of LIL3 with <span class="hlt">POR</span> but not with chlorophyll synthase. Consistently, LIL3-deficient plants exhibit substantial loss of <span class="hlt">POR</span> as well as CHLP, which is not due to defective transcription of the <span class="hlt">POR</span> and CHLP genes but to the posttranslational modification of their protein products. Interestingly, in vitro biochemical analyses provide novel evidence that LIL3 shows high binding affinity to protochlorophyllide, the substrate of <span class="hlt">POR</span>. Taken together, this study suggests a critical role for LIL3 in the organization of later steps in chlorophyll biosynthesis. We suggest that LIL3 associates with <span class="hlt">POR</span> and CHLP and thus contributes to the supply of the two metabolites, chlorophyllide and phytyl pyrophosphate, required for the final step in chlorophyll a synthesis. PMID:28432258</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27198078','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27198078"><span>Sunburn and sun-protective behaviors among adults with and without previous nonmelanoma skin cancer (NMSC): A population-based study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Fischer, Alexander H; Wang, Timothy S; Yenokyan, Gayane; Kang, Sewon; Chien, Anna L</p> <p>2016-08-01</p> <p>Individuals with previous nonmelanoma skin cancer (NMSC) are at increased risk for subsequent skin cancer, and should therefore limit ultraviolet exposure. We sought to determine whether individuals with previous NMSC engage in better sun protection than those with no skin cancer history. We pooled self-reported data (2005 and 2010 National Health Interview Surveys) from US non-Hispanic white adults (758 with and 34,161 without previous NMSC). We calculated adjusted prevalence odds ratios (a<span class="hlt">POR</span>) and 95% confidence intervals (CI), taking into account the complex survey design. Individuals with previous NMSC versus no history of NMSC had higher rates of frequent use of shade (44.3% vs 27.0%; a<span class="hlt">POR</span> 1.41; 95% CI 1.16-1.71), long sleeves (20.5% vs 7.7%; a<span class="hlt">POR</span> 1.55; 95% CI 1.21-1.98), a wide-brimmed hat (26.1% vs 10.5%; a<span class="hlt">POR</span> 1.52; 95% CI 1.24-1.87), and sunscreen (53.7% vs 33.1%; a<span class="hlt">POR</span> 2.11; 95% CI 1.73-2.59), but did not have significantly lower odds of recent sunburn (29.7% vs 40.7%; a<span class="hlt">POR</span> 0.95; 95% CI 0.77-1.17). Among those with previous NMSC, recent sunburn was inversely associated with age, sun avoidance, and shade but not sunscreen. Self-reported cross-sectional data and unavailable information quantifying regular sun exposure are limitations. Physicians should emphasize sunburn prevention when counseling patients with previous NMSC, especially younger adults, focusing on shade and sun avoidance over sunscreen. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28432258','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28432258"><span>LIL3, a Light-Harvesting Complex Protein, Links Terpenoid and Tetrapyrrole Biosynthesis in Arabidopsis thaliana.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hey, Daniel; Rothbart, Maxi; Herbst, Josephine; Wang, Peng; Müller, Jakob; Wittmann, Daniel; Gruhl, Kirsten; Grimm, Bernhard</p> <p>2017-06-01</p> <p>The LIL3 protein of Arabidopsis ( Arabidopsis thaliana ) belongs to the light-harvesting complex (LHC) protein family, which also includes the light-harvesting chlorophyll-binding proteins of photosystems I and II, the early-light-inducible proteins, PsbS involved in nonphotochemical quenching, and the one-helix proteins and their cyanobacterial homologs designated high-light-inducible proteins. Each member of this family is characterized by one or two LHC transmembrane domains (referred to as the LHC motif) to which potential functions such as chlorophyll binding, protein interaction, and integration of interacting partners into the plastid membranes have been attributed. Initially, LIL3 was shown to interact with geranylgeranyl reductase (CHLP), an enzyme of terpene biosynthesis that supplies the hydrocarbon chain for chlorophyll and tocopherol. Here, we show another function of LIL3 for the stability of protochlorophyllide oxidoreductase (<span class="hlt">POR</span>). Multiple protein-protein interaction analyses suggest the direct physical interaction of LIL3 with <span class="hlt">POR</span> but not with chlorophyll synthase. Consistently, LIL3-deficient plants exhibit substantial loss of <span class="hlt">POR</span> as well as CHLP, which is not due to defective transcription of the <span class="hlt">POR</span> and CHLP genes but to the posttranslational modification of their protein products. Interestingly, in vitro biochemical analyses provide novel evidence that LIL3 shows high binding affinity to protochlorophyllide, the substrate of <span class="hlt">POR</span>. Taken together, this study suggests a critical role for LIL3 in the organization of later steps in chlorophyll biosynthesis. We suggest that LIL3 associates with <span class="hlt">POR</span> and CHLP and thus contributes to the supply of the two metabolites, chlorophyllide and phytyl pyrophosphate, required for the final step in chlorophyll a synthesis. © 2017 American Society of Plant Biologists. All Rights Reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29434453','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29434453"><span>Faecal calprotectin and magnetic resonance imaging in detecting Crohn's disease endoscopic postoperative recurrence.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Baillet, Pierre; Cadiot, Guillaume; Goutte, Marion; Goutorbe, Felix; Brixi, Hedia; Hoeffel, Christine; Allimant, Christophe; Reymond, Maud; Obritin-Guilhen, Hélène; Magnin, Benoit; Bommelaer, Gilles; Pereira, Bruno; Hordonneau, Constance; Buisson, Anthony</p> <p>2018-02-07</p> <p>To assess magnetic resonance imaging (MRI) and faecal calprotectin to detect endoscopic postoperative recurrence in patients with Crohn's disease (CD). From two tertiary centers, all patients with CD who underwent ileocolonic resection were consecutively and prospectively included. All the patients underwent MRI and endoscopy within the first year after surgery or after the restoration of intestinal continuity [median = 6 mo (5.0-9.3)]. The stools were collected the day before the colonoscopy to evaluate faecal calprotectin level. Endoscopic postoperative recurrence (<span class="hlt">POR</span>) was defined as Rutgeerts' index ≥ i2b. The MRI was analyzed independently by two radiologists blinded from clinical data. Apparent diffusion coefficient (ADC) was lower in patients with endoscopic <span class="hlt">POR</span> compared to those with no recurrence (2.03 ± 0.32 vs 2.27 ± 0.38 × 10 -3 mm²/s, P = 0.032). Clermont score (10.4 ± 5.8 vs 7.4 ± 4.5, P = 0.038) and relative contrast enhancement (RCE) (129.4% ± 62.8% vs 76.4% ± 32.6%, P = 0.007) were significantly associated with endoscopic <span class="hlt">POR</span> contrary to the magnetic resonance index of activity (MaRIA) (7.3 ± 4.5 vs 4.8 ± 3.7; P = 0.15) and MR scoring system ( P = 0.056). ADC < 2.35 × 10 -3 mm²/s [sensitivity = 0.85, specificity = 0.65, positive predictive value (PPV) = 0.85, negative predictive value (NPV) = 0.65] and RCE > 100% (sensitivity = 0.75, specificity = 0.81, PPV = 0.75, NPV = 0.81) were the best cut-off values to identify endoscopic <span class="hlt">POR</span>. Clermont score > 6.4 (sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74), MaRIA > 3.76 (sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74) and a MR scoring system ≥ MR1 (sensitivity = 0.54, specificity = 0.82, PPV = 0.70, and NPV = 0.70) demonstrated interesting performances to detect endoscopic <span class="hlt">POR</span>. Faecal calprotectin values were significantly higher in patients with endoscopic <span class="hlt">POR</span> (114 ± 54.5 μg/g vs 354.8 ± 432.5 μg/g; P = 0.0075). Faecal calprotectin > 100 </p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5799865','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5799865"><span>Faecal calprotectin and magnetic resonance imaging in detecting Crohn’s disease endoscopic postoperative recurrence</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Baillet, Pierre; Cadiot, Guillaume; Goutte, Marion; Goutorbe, Felix; Brixi, Hedia; Hoeffel, Christine; Allimant, Christophe; Reymond, Maud; Obritin-Guilhen, Hélène; Magnin, Benoit; Bommelaer, Gilles; Pereira, Bruno; Hordonneau, Constance; Buisson, Anthony</p> <p>2018-01-01</p> <p>AIM To assess magnetic resonance imaging (MRI) and faecal calprotectin to detect endoscopic postoperative recurrence in patients with Crohn’s disease (CD). METHODS From two tertiary centers, all patients with CD who underwent ileocolonic resection were consecutively and prospectively included. All the patients underwent MRI and endoscopy within the first year after surgery or after the restoration of intestinal continuity [median = 6 mo (5.0-9.3)]. The stools were collected the day before the colonoscopy to evaluate faecal calprotectin level. Endoscopic postoperative recurrence (<span class="hlt">POR</span>) was defined as Rutgeerts’ index ≥ i2b. The MRI was analyzed independently by two radiologists blinded from clinical data. RESULTS Apparent diffusion coefficient (ADC) was lower in patients with endoscopic <span class="hlt">POR</span> compared to those with no recurrence (2.03 ± 0.32 vs 2.27 ± 0.38 × 10-3 mm²/s, P = 0.032). Clermont score (10.4 ± 5.8 vs 7.4 ± 4.5, P = 0.038) and relative contrast enhancement (RCE) (129.4% ± 62.8% vs 76.4% ± 32.6%, P = 0.007) were significantly associated with endoscopic <span class="hlt">POR</span> contrary to the magnetic resonance index of activity (MaRIA) (7.3 ± 4.5 vs 4.8 ± 3.7; P = 0.15) and MR scoring system (P = 0.056). ADC < 2.35 × 10-3 mm²/s [sensitivity = 0.85, specificity = 0.65, positive predictive value (PPV) = 0.85, negative predictive value (NPV) = 0.65] and RCE > 100% (sensitivity = 0.75, specificity = 0.81, PPV = 0.75, NPV = 0.81) were the best cut-off values to identify endoscopic <span class="hlt">POR</span>. Clermont score > 6.4 (sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74), MaRIA > 3.76 (sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74) and a MR scoring system ≥ MR1 (sensitivity = 0.54, specificity = 0.82, PPV = 0.70, and NPV = 0.70) demonstrated interesting performances to detect endoscopic <span class="hlt">POR</span>. Faecal calprotectin values were significantly higher in patients with endoscopic <span class="hlt">POR</span> (114 ± 54.5 μg/g vs 354.8 ± 432.5 μg/g; P = 0.0075). Faecal</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2011-06-13/pdf/2011-14527.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2011-06-13/pdf/2011-14527.pdf"><span>76 FR 34296 - Proposed Collection; Comment Request for Forms 1040-PR and 1040-SS</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2011-06-13</p> <p>... Form 1040-PR, Planilla para la Declaraci[oacute]n de la Contribuci[oacute]n Federal sobre el Trabajo... Trabajo <span class="hlt">por</span> Cuenta Propia (Incluyendo el Cr[eacute]dito Tributario Adicional <span class="hlt">por</span> Hijos para Residentes... Subtitle A, and provide credit to the taxpayer's social security account. Anejo H-PR is used to compute...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-12-31/pdf/2012-31446.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-12-31/pdf/2012-31446.pdf"><span>77 FR 77017 - Certain Orange Juice From Brazil: Notice of Court Decision Not in Harmony With Final Results of...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-12-31</p> <p>..., International Trade Administration, Department of Commerce. SUMMARY: On October 24, 2012, the United States... juice (OJ) from Brazil covering the period of review (<span class="hlt">POR</span>) of March 1, 2008, through February 28, 2009... administrative review of OJ from Brazil covering the <span class="hlt">POR</span> of March 1, 2008, through February 28, 2009. See Certain...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.epa.gov/newsreleases/la-epa-ayuda-restaurar-el-laboratorio-de-ciencias-de-puerto-rico-y-las-capacidades-de','PESTICIDES'); return false;" href="https://www.epa.gov/newsreleases/la-epa-ayuda-restaurar-el-laboratorio-de-ciencias-de-puerto-rico-y-las-capacidades-de"><span>La EPA ayuda a restaurar el laboratorio de ciencias de Puerto Rico y las capacidades de monitorear la calidad del aire</span></a></p> <p><a target="_blank" href="http://www.epa.gov/pesticides/search.htm">EPA Pesticide Factsheets</a></p> <p></p> <p></p> <p>La EPA continúa ayudando a Puerto Rico a responder tras los daños causados <span class="hlt">por</span> los huracanes Irma y María. La EPA, conforme a una misión asignada <span class="hlt">por</span> FEMA, y en estrecha cooperación con el gobierno de Puerto Rico, se encuentra apoya</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29762131','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29762131"><span>Two dimensional self-assembly zinc porphyrins and zinc phthalocyanines heterojunctions with record high power conversion efficiencies.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Yu, Junting; Jiang, Zhou; Hao, Yifan; Zhu, Qianhong; Zhao, Mingliang; Jiang, Xue; Zhao, Jijun</p> <p>2018-05-15</p> <p>Compared to inorganic solar cells, the power conversion efficiencies (PCEs) of organic solar cells are much lower, but they are compensated by many merits such as lower cost, less weight, and tunable structures, making them prospective for further applications. Porphyrin and phthalocyanine are the two most significant materials for organic solar cells due to their strong light-absorbing properties and semiconductor characteristics. However, there is little research on the 2D heterojunction solar cells based on these two materials, meanwhile the PCEs of them are still low. Here we have self-assembled several 2D Zinc-porphyrins (Zn<span class="hlt">Pors</span>) and performed first-principles simulation to demonstrate their good stability, suitable light harvesting, and high charge carrier mobility. By perfectly matching lattice constants and band levels between those 2D Zn<span class="hlt">Pors</span> and our previous proposed ZnPcs, eleven type-II organic heterojunctions are constructed to further improve their charge separation capability. Those advantages endow 2D Zn<span class="hlt">Pors</span> and ZnPcs appreciable PCEs for solar cell. Among them, the theoretical PCE of 2D Zn<span class="hlt">Pors</span>/ZnPcs heterojunctions achieves as high as 19.84%, which prevails all reported organic solar cells, and even approaches the PCEs of inorganic solar cells. These results indicate that our 2D Zn<span class="hlt">Pors</span> and 2D ZnPcs are good candidate materials for future organic solar cells. © 2018 IOP Publishing Ltd.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_21 --> <div id="page_22" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="421"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JPCM...30yLT02Y','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JPCM...30yLT02Y"><span>Two dimensional self-assembly zinc porphyrin and zinc phthalocyanine heterojunctions with record high power conversion efficiencies</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Yu, Junting; Jiang, Zhou; Hao, Yifan; Zhu, Qianhong; Zhao, Mingliang; Jiang, Xue; Zhao, Jijun</p> <p>2018-06-01</p> <p>Compared to inorganic solar cells, the power conversion efficiencies (PCEs) of organic solar cells are much lower, but they are compensated by many merits such as lower cost, less weight, and tunable structures, making them prospective for further applications. Porphyrin and phthalocyanine are the two most significant materials for organic solar cells due to their strong light-absorbing properties and semiconductor characteristics. However, there is little research on the 2D heterojunction solar cells based on these two materials, meanwhile the PCEs of them are still low. Here we have self-assembled several 2D zinc porphyrins (Zn<span class="hlt">Pors</span>) and performed first-principles simulation to demonstrate their good stability, suitable light harvesting, and high charge carrier mobility. By perfectly matching lattice constants and molecular energy levels between those 2D Zn<span class="hlt">Pors</span> and our previous proposed zinc phthalocyanines (ZnPcs), 11 type-II organic heterojunctions are constructed to further improve their charge separation capability. Those advantages endow 2D Zn<span class="hlt">Pors</span> and ZnPcs appreciable PCEs for solar cells. Among them, the theoretical PCE of 2D Zn<span class="hlt">Pors</span>/ZnPcs heterojunctions achieves as high as 19.84%, which exceeds all reported organic solar cells, and even approaches the PCEs of inorganic solar cells. These results indicate that our 2D Zn<span class="hlt">Pors</span> and 2D ZnPcs are good candidate materials for future organic solar cells.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2013-12-31/pdf/2013-31344.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2013-12-31/pdf/2013-31344.pdf"><span>78 FR 79665 - Welded Carbon Steel Standard Pipe and Tube Products From Turkey: Final Results of Antidumping...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2013-12-31</p> <p>... Pipe and Tube Products From Turkey: Final Results of Antidumping Duty Administrative Review; 2011-2012... pipe and tube products (welded pipe and tube) from Turkey.\\1\\ The period of review (<span class="hlt">POR</span>) is May 1, 2011... during the <span class="hlt">POR</span>.\\2\\ \\1\\ See Welded Carbon Steel Standard Pipe and Tube Products from Turkey: Preliminary...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016SPIE10005E..0DD','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016SPIE10005E..0DD"><span>MicMac GIS application: free open source</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Duarte, L.; Moutinho, O.; Teodoro, A.</p> <p>2016-10-01</p> <p>The use of Remotely Piloted Aerial System (RPAS) for remote sensing applications is becoming more frequent as the technologies on on-board cameras and the platform itself are becoming a serious contender to satellite and airplane imagery. MicMac is a photogrammetric tool for image matching that can be used in different contexts. It is an open source software and it can be used as a command line or with a graphic interface (for each command). The main objective of this work was the integration of MicMac with QGIS, which is also an open source software, in order to create a new open source tool applied to photogrammetry/remote sensing. Python language was used to develop the application. This tool would be very useful in the manipulation and 3D modelling of a set of images. The main objective was to create a toolbar in QGIS with the basic functionalities with intuitive graphic interfaces. The toolbar is composed by three buttons: produce the points cloud, create the Digital Elevation Model (DEM) and produce the orthophoto of the study area. The application was tested considering 35 photos, a subset of images acquired by a RPAS in the <span class="hlt">Aguda</span> beach area, Porto, Portugal. They were used in order to create a 3D terrain model and from this model obtain an orthophoto and the corresponding DEM. The code is open and can be modified according to the user requirements. This integration would be very useful in photogrammetry and remote sensing community combined with GIS capabilities.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5900743','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5900743"><span>Differentiation‐associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic‐metabolizing activity of “luminal” muscle‐invasive bladder cancers</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Arlt, Volker M.; Indra, Radek; Joel, Madeleine; Stiborová, Marie; Eardley, Ian; Ahmad, Niaz; Otto, Wolfgang; Burger, Maximilian; Rubenwolf, Peter; Phillips, David H.; Southgate, Jennifer</p> <p>2018-01-01</p> <p>Extra‐hepatic metabolism of xenobiotics by epithelial tissues has evolved as a self‐defence mechanism but has potential to contribute to the local activation of carcinogens. Bladder epithelium (urothelium) is bathed in excreted urinary toxicants and pro‐carcinogens. This study reveals how differentiation affects cytochrome P450 (CYP) activity and the role of NADPH:P450 oxidoreductase (<span class="hlt">POR</span>). CYP1A1 and CYP1B1 transcripts were inducible in normal human urothelial (NHU) cells maintained in both undifferentiated and functional barrier‐forming differentiated states in vitro. However, ethoxyresorufin O‐deethylation (EROD) activity, the generation of reactive BaP metabolites and BaP‐DNA adducts, were predominantly detected in differentiated NHU cell cultures. This gain‐of‐function was attributable to the expression of <span class="hlt">POR</span>, an essential electron donor for all CYPs, which was significantly upregulated as part of urothelial differentiation. Immunohistology of muscle‐invasive bladder cancer (MIBC) revealed significant overall suppression of <span class="hlt">POR</span> expression. Stratification of MIBC biopsies into “luminal” and “basal” groups, based on GATA3 and cytokeratin 5/6 labeling, showed <span class="hlt">POR</span> over‐expression by a subgroup of the differentiated luminal tumors. In bladder cancer cell lines, CYP1‐activity was undetectable/low in basal PORlo T24 and SCaBER cells and higher in the luminal <span class="hlt">POR</span> over‐expressing RT4 and RT112 cells than in differentiated NHU cells, indicating that CYP‐function is related to differentiation status in bladder cancers. This study establishes <span class="hlt">POR</span> as a predictive biomarker of metabolic potential. This has implications in bladder carcinogenesis for the hepatic versus local activation of carcinogens and as a functional predictor of the potential for MIBC to respond to prodrug therapies. PMID:29323757</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23567352','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23567352"><span>Association of low dietary intake of fiber and liquids with constipation: evidence from the National Health and Nutrition Examination Survey.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Markland, Alayne D; Palsson, Olafur; Goode, Patricia S; Burgio, Kathryn L; Busby-Whitehead, Jan; Whitehead, William E</p> <p>2013-05-01</p> <p>Epidemiological studies support an association of self-defined constipation with fiber and physical activity, but not liquid intake. The aims of this study were to assess the prevalence and associations of dietary fiber and liquid intake to constipation. Analyses were based on data from 10,914 adults (≥20 years) from the 2005-2008 cycles of the National Health and Nutrition Examination Surveys. Constipation was defined as hard or lumpy stools (Bristol Stool Scale type 1 or 2) as the "usual or most common stool type." Dietary fiber and liquid intake from total moisture content were obtained from dietary recall. Co-variables included: age, race, education, poverty income ratio, body mass index, self-reported general health status, chronic illnesses, and physical activity. Prevalence estimates and prevalence odds ratios (<span class="hlt">POR</span>) were analyzed in adjusted multivariable models using appropriate sampling weights. Overall, 9,373 (85.9%) adults (4,787 women and 4,586 men) had complete stool consistency and dietary data. Constipation rates were 10.2% (95% confidence interval (CI): 9.6, 10.9) for women and 4.0% (95% CI: 3.2, 5.0) for men (P<.001). After multivariable adjustment, low liquid consumption remained a predictor of constipation among women (<span class="hlt">POR</span>: 1.3, 95% CI: 1.0, 1.6) and men (<span class="hlt">POR</span>: 2.4, 95% CI: 1.5, 3.9); however, dietary fiber was not a predictor. Among women, African-American race/ethnicity (<span class="hlt">POR</span>: 1.4, 95% CI: 1.0, 1.9), being obese (<span class="hlt">POR</span>: 0.7, 95% CI: 0.5,0.9), and having a higher education level (<span class="hlt">POR</span>: 0.8, 95% CI: 0.7, 0.9) were significantly associated with constipation. The findings support clinical recommendations to treat constipation with increased liquid, but not fiber or exercise.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3786707','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3786707"><span>Association of Low Dietary Intake of Fiber and Liquids with Constipation: Evidence from the National Health and Nutrition Examination Survey (NHANES)</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Markland, Alayne D.; Palsson, Olafur; Goode, Patricia S.; Burgio, Kathryn L.; Busby-Whitehead, Jan; Whitehead, William E.</p> <p>2013-01-01</p> <p>Objective Epidemiological studies support an association of self-defined constipation with fiber and physical activity, but not liquid intake. The aims of this study were to assess the prevalence and associations of dietary fiber and liquid intake to constipation. Methods Analyses were based on data from 10,914 adults (≥20 years) from the 2005-2008 cycles of the National Health and Nutrition Examination Surveys (NHANES). Constipation was defined as hard or lumpy stools (Bristol Stool Scale types 1 or 2) as the “usual or most common stool type.” Dietary fiber and liquid intake from total moisture content were obtained from dietary recall. Co-variables included: age, race, education, poverty income ratio, body mass index, self-reported general health status, chronic illnesses, and physical activity. Prevalence estimates and prevalence odds ratios (<span class="hlt">POR</span>) were analyzed in adjusted multivariable models using appropriate sampling weights. Results Overall, 9,373 (85.9%) adults (4,787 women and 4,586 men) had complete stool consistency and dietary data. Constipation rates were 10.2% (95% CI: 9.6,10.9) for women and 4.0 (95% CI: 3.2,5.0) for men (p<.001). After multivariable adjustment, low liquid consumption remained a predictor of constipation among women (<span class="hlt">POR</span>: 1.3, 95% CI: 1.0,1.6) and men (<span class="hlt">POR</span>: 2.4, 95% CI: 1.5,3.9); however, dietary fiber was not a predictor. Among women, African-American race/ethnicity (<span class="hlt">POR</span>: 1.4, 95% CI: 1.0,1.9), being obese (<span class="hlt">POR</span>: 0.7, 95% CI: 0.5,0.9), and having a higher education level (<span class="hlt">POR</span>: 0.8, 95% CI: 0.7,0.9) were significantly associated with constipation. Conclusions The findings support clinical recommendations to treat constipation with increased liquid, but not fiber or exercise. PMID:23567352</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28562742','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28562742"><span>Factors associated with the incidence of pressure ulcer during hospital stay.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Matozinhos, Fernanda Penido; Velasquez-Melendez, Gustavo; Tiensoli, Sabrina Daros; Moreira, Alexandra Dias; Gomes, Flávia Sampaio Latini</p> <p>2017-05-25</p> <p>Estimating the incidence rate of pressure ulcers and verifying factors associated with this occurrence in a cohort of hospitalized patients. This is a cohort study in which the considered outcome was the time until pressure ulcer occurrence. Estimated effect of the variables on the cumulative incidence ratio of the outcome was performed using the Cox proportional hazards model. Variable selection occurred via the Logrank hypothesis test. The sample consisted of 442 adults, with 25 incidents of pressure ulcers. Patients with high scores on the Braden scale presented a higher risk of pressure ulcer incidence when compared to those classified into the low score category. These results reinforce the importance of using the Braden Scale to assist in identifying patients more likely to develop pressure ulcers. Estimar a taxa de incidência de úlcera <span class="hlt">por</span> pressão e verificar fatores associados a essa ocorrência em uma coorte de pacientes hospitalizados. Trata-se de estudo de coorte no qual o desfecho foi a ocorrência da úlcera <span class="hlt">por</span> pressão. A estimativa do efeito das variáveis para a proporção de incidência acumulada do desfecho foi realizada utilizando o modelo de riscos proporcionais de Cox. A seleção das variáveis ocorreu <span class="hlt">por</span> meio do teste de hipóteses Logrank. A amostra foi composta de 442 adultos, com 25 casos incidentes de úlcera <span class="hlt">por</span> pressão. Pacientes com altos escores na escala de Braden apresentaram maior risco de incidência de úlcera <span class="hlt">por</span> pressão quando comparados com aqueles classificados na categoria de baixo escore. Os resultados reforçam a importância do uso da Escala de Braden para auxiliar na identificação dos pacientes com maior probabilidade de desenvolver úlcera <span class="hlt">por</span> pressão.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29750773','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29750773"><span>Missed Opportunities for Human Immunodeficiency Virus and Syphilis Testing Among Men Who Have Sex With Men in China: A Cross-Sectional Study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ong, Jason J; Fu, Hongyun; Pan, Stephen; Smith, M Kumi; Wu, Dan; Wei, Chongyi; Cao, Bolin; Ma, Wei; Yang, Ligang; Tang, Weiming; Tucker, Joseph D</p> <p>2018-06-01</p> <p>Men who have sex with men (MSM) are at high risk of human immunodeficiency virus (HIV)/syphilis. To inform strategies for dual testing, we describe patterns of HIV/syphilis testing, and examine factors associated with never testing for HIV/syphilis in China. An online survey (2016) was completed by MSM from 8 cities: men born biologically male, 16 years or older, and had sex with another man at least once during their lifetime. Demographic, sexual behavioral, and HIV/syphilis testing data were collected. Multivariable multinomial logistic regression identified characteristics associated with men who never tested for HIV/syphilis compared with men who ever tested for both infections. Overall, 2105 men participated. Among them, 35.1% (738/2105) never tested for HIV/syphilis, and in those ever tested for HIV, only half (54.0%, 709/1312) had tested for syphilis. Relative to men who had ever tested for both infections, those with increased probability of never testing for HIV/syphilis include non-gay sexual identity (prevalence odds ratio [<span class="hlt">POR</span>] 1.86; 95% confidence interval [CI], 1.45-2.37), not disclosed their sexuality/sexual history with men other than their regular partner (<span class="hlt">POR</span>, 2.22; 95% CI, 1.75-2.78]) or with health professionals (<span class="hlt">POR</span>, 11.11; 95% CI, 7.69-14.29), no condomless sex with casual partners in the last 3 months (<span class="hlt">POR</span>, 1.89; 95% CI, 1.37-2.56), no community engagement in sexual health (<span class="hlt">POR</span>, 15.16; 95% CI, 9.40-24.45), and mainly met partners offline (<span class="hlt">POR</span>, 1.49; 95% CI, 1.16-1.92). There are significant gaps in lifetime testing for HIV/syphilis among Chinese MSM. Strategies to target never testers and integrate syphilis testing within HIV testing services are urgently needed. Future opportunities include point-of-care dual test kits, and testing in China's expanding primary healthcare system.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22293242','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22293242"><span>Does open-air exposure to volatile organic compounds near a plastic recycling factory cause health effects?</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Yorifuji, Takashi; Noguchi, Miyuki; Tsuda, Toshihide; Suzuki, Etsuji; Takao, Soshi; Kashima, Saori; Yanagisawa, Yukio</p> <p>2012-01-01</p> <p>After a plastic reprocessing factory began to operate in August 2004, the residents around the factory in Neyagawa, Osaka, Japan, began to complain of symptoms. Therefore, we conducted an exposure assessment and a population-based epidemiological study in 2006. To assess exposure, volatile organic compounds (VOCs) and total VOCs were measured at two locations in the vicinity of the factory. In the population-based study, a total of 3,950 residents were targeted. A self-administered questionnaire was used to collect information about subjects' mucocutaneous or respiratory symptoms. Using logistic regression models, we compared the prevalence of symptoms in July 2006 by employing the farthest area from the factory as a reference, and prevalence odds ratios (<span class="hlt">PORs</span>) and their 95% confidence intervals (CIs) were estimated. The concentration of total VOCs was higher in the vicinity of the factory. The prevalence of mucocutaneous and respiratory symptoms was the highest among the residents in the closest area to the factory. Some symptoms were significantly increased among the residents within 500 m of the factory compared with residents of an area 2800 m from the factory: e.g., sore throat (<span class="hlt">POR</span>=3.2, 95% CI: 1.3-8.0), eye itch (<span class="hlt">POR</span>=3.0, 95% CI: 1.5-6.0), eye discharge (<span class="hlt">POR</span>=6.0, 95% CI: 2.3-15.9), eczema (<span class="hlt">POR</span>=3.0, 95% CI: 1.1-7.9) and sputum (<span class="hlt">POR</span>=2.4, 95% CI: 1.1-5.1). Despite of the limitations of this study, these results imply a possible association of open-air VOCs with mucocutaneous and respiratory symptoms. Because this kind of plasticre cycling factory only recently came into operation, more attention should be paid to the operation of plastic recycling factories in the environment.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29890109','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29890109"><span></span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dipierri, José Edgardo; Bronberg, Rubén Adrian</p> <p>2017-09-08</p> <p>Debido al incremento de casos de microcefalia <span class="hlt">por</span> virus Zika en Brasil el Ministerio de Salud de Argentina recomienda incrementar la vigilancia de esta malformación. A fin de profundizar el conocimiento del comportamiento epidemiológico de microcefalia en el país se analiza la mortalidad infantil <span class="hlt">por</span> microcefalia entre 1998-2012. Los datos proceden de la Dirección de Estadísticas e Información de Salud (DEIS). Se calculó <span class="hlt">por</span> provincias y regiones la tasa de mortalidad infantil <span class="hlt">por</span> microcefalia (TMI-M) y se realizó un análisis de agrupamiento a nivel departamental. Las tasas más elevadas se observaron en las regiones y provincias del norte del país. La distribución espacial de la TMI-M guarda relación con las prevalencias de microcefalia en recién nacidos. Esta distribución se relaciona con la mayor pobreza y consanguinidad del norte de la Argentina, factores sinérgicos predisponentes de la ocurrencia de malformaciones congénitas en general y de microcefalia en particular.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27737328','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27737328"><span>Long-term follow-up of a female with congenital adrenal hyperplasia due to P450-oxidoreductase deficiency.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bonamichi, Beatriz D S F; Santiago, Stella L M; Bertola, Débora R; Kim, Chong A; Alonso, Nivaldo; Mendonca, Berenice B; Bachega, Tania A S S; Gomes, Larissa G</p> <p>2016-10-01</p> <p>P450 oxidoreductase deficiency (PORD) is a variant of congenital adrenal hyperplasia that is caused by <span class="hlt">POR</span> gene mutations. The <span class="hlt">POR</span> gene encodes a flavor protein that transfers electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to all microsomal cytochrome P450 type II (including 21-hydroxylase, 17α-hydroxylase 17,20 lyase and aromatase), which is fundamental for their enzymatic activity. <span class="hlt">POR</span> mutations cause variable impairments in steroidogenic enzyme activities that result in wide phenotypic variability ranging from 46,XX or 46,XY disorders of sexual differentiation, glucocorticoid deficiency, with or without skeletal malformations similar to Antley-Bixler syndrome to asymptomatic newborns diagnosed during neonatal screening test. Little is known about the PORD long-term evolution. We described a 46,XX patient with mild atypical genitalia associated with severe bone malformation, who was diagnosed after 13 years due to sexual infantilism. She developed large ovarian cysts and late onset adrenal insufficiency during follow-up, both of each regressed after hormone replacement therapies. We also described a late surgical approach for the correction of facial hypoplasia in a <span class="hlt">POR</span> patient.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5441670','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5441670"><span>Observational study to calculate addictive risk to opioids: a validation study of a predictive algorithm to evaluate opioid use disorder</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Brenton, Ashley; Richeimer, Steven; Sharma, Maneesh; Lee, Chee; Kantorovich, Svetlana; Blanchard, John; Meshkin, Brian</p> <p>2017-01-01</p> <p>Background Opioid abuse in chronic pain patients is a major public health issue, with rapidly increasing addiction rates and deaths from unintentional overdose more than quadrupling since 1999. Purpose This study seeks to determine the predictability of aberrant behavior to opioids using a comprehensive scoring algorithm incorporating phenotypic risk factors and neuroscience-associated single-nucleotide polymorphisms (SNPs). Patients and methods The Proove Opioid Risk (<span class="hlt">POR</span>) algorithm determines the predictability of aberrant behavior to opioids using a comprehensive scoring algorithm incorporating phenotypic risk factors and neuroscience-associated SNPs. In a validation study with 258 subjects with diagnosed opioid use disorder (OUD) and 650 controls who reported using opioids, the <span class="hlt">POR</span> successfully categorized patients at high and moderate risks of opioid misuse or abuse with 95.7% sensitivity. Regardless of changes in the prevalence of opioid misuse or abuse, the sensitivity of <span class="hlt">POR</span> remained >95%. Conclusion The <span class="hlt">POR</span> correctly stratifies patients into low-, moderate-, and high-risk categories to appropriately identify patients at need for additional guidance, monitoring, or treatment changes. PMID:28572737</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27571645','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27571645"><span>[Not Available].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ortega, Rosa M</p> <p>2016-07-19</p> <p>El artículo de San Mauro y cols. profundiza en un tema de interés prioritario como es el estudio de los hábitos de ingesta de fluidos en personas de cuatro países: España, Portugal, México y Uruguay, para analizar si se cumplen (y si se conocen) las pautas de hidratación marcadas como adecuadas <span class="hlt">por</span> organismos oficiales y, en concreto, <span class="hlt">por</span> la EFSA. Es indudable la importancia de una correcta hidratación pues mientras que se puede vivir meses, o años, con una alimentación incorrecta, la deshidratación puede llevar a la muerte en un escaso periodo de tiempo. <span class="hlt">Por</span> otra parte, un aporte ligeramente insuficiente de fluidos perjudica la salud, capacidad funcional y calidad de vida del individuo, <span class="hlt">por</span> lo que debe ser evitada. Incluso algunos estudios encuentran hábitos y estilo de vida menos saludables en individuos con menor consumo de fluidos y pautas de hidratación más incorrectas.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29775038','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29775038"><span>Postinfectious bronchiolitis obliterans</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p></p> <p>2018-06-01</p> <p>La bronquiolitis obliterante es una enfermedad pulmonar crónica infrecuente y grave producto de una lesión del tracto respiratorio inferior. En nuestro país, es más frecuente observarla secundaria a una lesión viral grave, en especial, <span class="hlt">por</span> adenovirus. La bronquiolitis obliterante se caracteriza <span class="hlt">por</span> la oclusión parcial o total del lumen de los bronquiolos respiratorios y terminales <span class="hlt">por</span> tejido inflamatorio y fibrosis, que produce la obstrucción crónica de la vía aérea. Este consenso discute el estado actual del conocimiento en las diferentes áreas de la bronquiolitis obliterante secundaria a una lesión infecciosa.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.fs.usda.gov/treesearch/pubs/6456','TREESEARCH'); return false;" href="https://www.fs.usda.gov/treesearch/pubs/6456"><span>Mortalidade em florestas de Pinus palustris causada <span class="hlt">por</span> tempestade de raios</span></a></p> <p><a target="_blank" href="http://www.fs.usda.gov/treesearch/">Treesearch</a></p> <p>Kenneth W. Outcalt; Jorge Paladino Corrêa de Lima; Jose Américo de Mello Filho</p> <p>2002-01-01</p> <p>The importance of lightning as an ignition source for the fire driven Pinus palustris ecosystem is widely recognized. Lightning also impacts this system on a smaller scale by causing individual tree mortality. The objective of this study was to determine the level of mortality due to lightning activity at the Department of Energy's Savannah...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017EPJWC.15806004A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017EPJWC.15806004A"><span>Betavoltaic device in <span class="hlt">por</span>-SiC/Si C-Nuclear Energy Converter</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Akimchenko, Alina; Chepurnov, Victor; Dolgopolov, Mikhail; Gurskaya, Albina; Kuznetsov, Oleg; Mashnin, Alikhan; Radenko, Vitaliy; Radenko, Alexander; Surnin, Oleg; Zanin, George</p> <p>2017-10-01</p> <p>The miniature and low-power devices with long service life in hard operating conditions like the Carbon-14 beta-decay energy converters indeed as eternal resource for integrated MEMS and NEMS are considered. Authors discuss how to create the power supply for MEMS/NEMS devices, based on porous SiC/Si structure, which are tested to be used as the beta-decay energy converters of radioactive C-14 into electrical energy. This is based on the silicon carbide obtaining by self-organizing mono 3C-SiC endotaxy on the Si substrate. The new idea is the C-14 atoms including in molecules in the silicon carbide porous structure by this technology, which will increase the efficiency of the converter due to the greater intensity of electron-hole pairs generation rate in the space charge region. The synthesis of C-14 can be also performed by using the electronically controlled magneto-optic chamber.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=metodos+AND+de+AND+separacion+AND+por+AND+decantacion%7d&pg=2&id=EJ861993','ERIC'); return false;" href="https://eric.ed.gov/?q=metodos+AND+de+AND+separacion+AND+por+AND+decantacion%7d&pg=2&id=EJ861993"><span>Applying Cognitive Linguistics to Teaching the Spanish Prepositions "<span class="hlt">Por</span>" and "Para"</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Lam, Yvonne</p> <p>2009-01-01</p> <p>L2 prepositions are traditionally taught in a non-explanatory manner by having students learn each use individually. This study examines the effectiveness of an alternative explanatory approach based on cognitive linguistics, which considers the multiple uses of a preposition as related. Consequently, learners can be shown a general schema that…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=metodos+AND+de+AND+separacion+AND+por+AND+decantacion%7d&pg=5&id=EJ1030404','ERIC'); return false;" href="https://eric.ed.gov/?q=metodos+AND+de+AND+separacion+AND+por+AND+decantacion%7d&pg=5&id=EJ1030404"><span>"<span class="hlt">Por</span> Los Ojos De Madres": Latina Mothers' Understandings of College Readiness</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Cortez, Laura Jean; Martinez, Melissa Ann; Sáenz, Victor B.</p> <p>2014-01-01</p> <p>In this study, data from six focus groups with 30 Latina mothers in South Texas were analyzed utilizing a "funds of knowledge" approach to uncover their understandings of college readiness and their role in ensuring their children are college ready. Findings indicate that Latina mothers perceived college readiness in a holistic fashion,…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/publication/?seqNo115=332742','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/publication/?seqNo115=332742"><span>Intoxicação experimental <span class="hlt">por</span> Niedenzuella stannea (Malpighiaceae) em ovinos</span></a></p> <p><a target="_blank" href="https://www.ars.usda.gov/research/publications/find-a-publication/">USDA-ARS?s Scientific Manuscript database</a></p> <p></p> <p></p> <p>Niedenzuella stannea a sodium monofluoroacetate-containing plant cause of sudden death in cattle in southern Mato Grosso State. This study describes the toxicity and clinical and pathological findings of experimental poisoning by N. stannea in sheep. Fruits, mature leaves and young leaves of the pla...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=dream&pg=5&id=EJ1156394','ERIC'); return false;" href="https://eric.ed.gov/?q=dream&pg=5&id=EJ1156394"><span>Mirta Yáñez's Dystopic Vision of Havana</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>González, Flora M.</p> <p>2017-01-01</p> <p>In her 2010 novel "Sangra <span class="hlt">por</span> la herida," the Cuban novelist, poet, and essayist Mirta Yáñez constructs a panoramic view of metropolitan Havana, following the model of Latin American fiction starting in the 1980s based on a revised version of the detective novel. "Sangra <span class="hlt">por</span> la herida" functions best as a narrative that…</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_22 --> <div id="page_23" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="441"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5576748','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5576748"><span>Perception of recovery of households affected by 2008 Wenchuan earthquake: A structural equation model</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Lin, Le; Wang, Ying; Liu, Tianxue</p> <p>2017-01-01</p> <p>Much of the literature on recovery focuses on the economy, the physical environment and infrastructure at a macro level, which may ignore the personal experiences of affected individuals during recovery. This paper combines internal factors at a micro level and external factors at a macro level to model for understanding perception of recovery (<span class="hlt">PoR</span>). This study focuses on areas devastated by the 2008 Wenchuan earthquake in China. With respect to three recovery-related aspects (house recovery condition (HRC), family recovery power (FRP) and reconstruction investment (RI)), structural equation modeling (SEM) was applied. It was found that the three aspects (FRP, HRC and RI) effectively explain how earthquake affected households perceive recovery. Internal factors associated with FRP contributed the most to favourable <span class="hlt">PoR</span>, followed by external factors associated with HRC. Findings identified that for <span class="hlt">PoR</span> the importance of active recovery within households outweighed an advantageous house recovery condition. At the same time, households trapped in unfavourable external conditions would invest more in housing recovery, which result in wealth accumulation and improved quality of life leading to a high level of <span class="hlt">PoR</span>. In addition, schooling in households showed a negative effect on improving <span class="hlt">PoR</span>. This research contributes to current debates around post-disaster permanent housing policy. It is implied that a one-size-fits-all policy in disaster recovery may not be effective and more specific assistance should be provided to those people in need. PMID:28854217</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=mundo&pg=5&id=ED462721','ERIC'); return false;" href="https://eric.ed.gov/?q=mundo&pg=5&id=ED462721"><span>See the World on the Internet: Tips for Parents of Young Readers--and "Surfers" = Vea el mundo <span class="hlt">por</span> Internet: Ideas <span class="hlt">por</span> padres de jovenes lectores y exploradores.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Moss, Jeanette</p> <p></p> <p>Regardless of whether a parent has Internet access at home, it is essential that parents learn with their children and be aware of where their travels on the Internet are taking them. Many libraries have Internet workshops for parents or children or both. In the excitement of looking at sites, children may not even realize they are reading. Many…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16163758','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16163758"><span>Hydrocarbon oxidation by beta-halogenated dioxoruthenium(VI) porphyrin complexes: effect of reduction potential (RuVI/V) and C-H bond-dissociation energy on rate constants.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Che, Chi-Ming; Zhang, Jun-Long; Zhang, Rui; Huang, Jie-Sheng; Lai, Tat-Shing; Tsui, Wai-Man; Zhou, Xiang-Ge; Zhou, Zhong-Yuan; Zhu, Nianyong; Chang, Chi Kwong</p> <p>2005-11-18</p> <p>beta-Halogenated dioxoruthenium(VI) porphyrin complexes [Ru(VI)(F(28)-tpp)O(2)] [F(28)-tpp=2,3,7,8,12,13, 17,18-octafluoro-5,10,15,20-tetrakis(pentafluorophenyl)porphyrinato(2-)] and [Ru(VI)(beta-Br(8)-tmp)O(2)] [beta-Br(8)-tmp=2,3,7,8,12,13,17,18-octabromo-5,10,15,20- tetrakis(2,4,6-trimethylphenyl)porphyrinato(2-)] were prepared from reactions of [Ru(II)(<span class="hlt">por</span>)(CO)] [<span class="hlt">por</span>=porphyrinato(2-)] with m-chloroperoxybenzoic acid in CH(2)Cl(2). Reactions of [Ru(VI)(<span class="hlt">por</span>)O(2)] with excess PPh(3) in CH(2)Cl(2) gave [Ru(II)(F(20)-tpp)(PPh(3))(2)] [F(20)-tpp=5,10,15,20-tetrakis(pentafluorophenyl)porphyrinato(2-)] and [Ru(II)(F(28)-tpp)(PPh(3))(2)]. The structures of [Ru(II)(<span class="hlt">por</span>)(CO)(H(2)O)] and [Ru(II)(<span class="hlt">por</span>)(PPh(3))(2)] (<span class="hlt">por</span>=F(20)-tpp, F(28)-tpp) were determined by X-ray crystallography, revealing the effect of beta-fluorination of the porphyrin ligand on the coordination of axial ligands to ruthenium atom. The X-ray crystal structure of [Ru(VI)(F(20)-tpp)O(2)] shows a Ru=O bond length of 1.718(3) A. Electrochemical reduction of [Ru(VI)(<span class="hlt">por</span>)O(2)] (Ru(VI) to Ru(V)) is irreversible or quasi-reversible, with the E(p,c)(Ru(VI/V)) spanning -0.31 to -1.15 V versus Cp(2)Fe(+/0). Kinetic studies were performed for the reactions of various [Ru(VI)(<span class="hlt">por</span>)O(2)], including [Ru(VI)(F(28)-tpp)O(2)] and [Ru(VI)(beta-Br(8)-tmp)O(2)], with para-substituted styrenes p-X-C(6)H(4)CH=CH(2) (X=H, F, Cl, Me, MeO), cis- and trans-beta-methylstyrene, cyclohexene, norbornene, ethylbenzene, cumene, 9,10-dihydroanthracene, xanthene, and fluorene. The second-order rate constants (k(2)) obtained for the hydrocarbon oxidations by [Ru(VI)(F(28)-tpp)O(2)] are up to 28-fold larger than by [Ru(VI)(F(20)-tpp)O(2)]. Dual-parameter Hammett correlation implies that the styrene oxidation by [Ru(VI)(F(28)-tpp)O(2)] should involve rate-limiting generation of a benzylic radical intermediate, and the spin delocalization effect is more important than the polar effect. The k(2) values for the oxidation of styrene and</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA545963','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA545963"><span>JIATF-SWB: Building an Operational Bridge for the Southwest Border</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2011-04-12</p> <p>mexican_cartels_integr.htm. (accessed 20 March 2011). 4 Office of the President. “Obtener la base de datos de Fallecimientos ocurridos <span class="hlt">por</span> presunta rivalidad...Obtener la base de datos de Fallecimientos ocurridos <span class="hlt">por</span> presunta rivalidad delincuencial en el periodo diciembre 2006 a diciembre 2010... basing , technical, intelligence, and training support to JIATF-SWB. 15. SUBJECT TERMS Mexico, Southwest Border, USNORTHCOM, Interagency, 16</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA564246','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA564246"><span>European Command Hazardous Material Management Program</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2011-05-12</p> <p>cause the hazard>; ES: Puede provocar cáncer <indíquese la vía de exposición si se ha demostrado concluyentemente que el peligro no se produce <span class="hlt">por</span>...demostrado concluyentemente que el peligro no se produce <span class="hlt">por</span> ninguna otra vía>. H302: Harmful if swallowed; ES: Nocivo en caso de ingestión. H317: May</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1061451','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1061451"><span>NADPH: Protochlorophyllide Oxidoreductase-Structure, Catalytic Function, and Role in Prolamellar Body Formation and Morphogenesis</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Timko, Michael P</p> <p>2013-02-01</p> <p>The biosynthesis of chlorophyll is a critical biochemical step in the development of photosynthetic vascular plants and green algae. From photosynthetic bacteria (cyanobacteria) to algae, non-vascular plants, gymnosperms and vascular plants, mechanisms have evolved for protochlorophyllide reduction a key step in chlorophyll synthesis. Protochlorophyllide reduction is carried out by both a light-dependent (<span class="hlt">POR</span>) and light-independent (LIPOR) mechanisms. NADPH: protochlorophyllide oxidoreductase (EC 1.3.1.33, abbreviated <span class="hlt">POR</span>) catalyzes the light-dependent reduction of protochlorophyllide (PChlide) to chlorophyllide (Chlide). In contrast, a light-independent protochlorophyllide reductase (LIPOR) involves three plastid gene products (chlL, chlN, and chlB) and several nuclear factors. Our work focused on characterization ofmore » both the <span class="hlt">POR</span> and LIPOR catalyzed processes.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27579936','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27579936"><span>Transcultural adaptation of the Johns Hopkins Fall Risk Assessment Tool.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Martinez, Maria Carmen; Iwamoto, Viviane Ernesto; Latorre, Maria do Rosário Dias de Oliveira; Noronha, Adriana Moreira; Oliveira, Ana Paula de Sousa; Cardoso, Carlos Eduardo Alves; Marques, Ifigenia Augusta Braga; Vendramim, Patrícia; Lopes, Paula Cristina; Sant'Ana, Thais Helena Saes de</p> <p>2016-08-29</p> <p>to perform the transcultural adaptation and content validity analysis of the Johns Hopkins Fall Risk Assessment Tool to assess both fall risk and fall-related injury risk for hospitalized elderly in Brazil. the transcultural adaptation consisted of translating the scale to Portuguese (Brazil), back-translating it into its language of origin, establishing a consensus version, and having an expert committee verify its transcultural equivalence. Content assessment was conducted by a committee of judges, ending with the calculation of the items and scales' content validity index. Nurses tested the tool. the scale's translated version went through two evaluation rounds by the judges, based on which, the items with unsatisfactory performance were changed. The content validity index for the items was ≥80.0% and the global index 97.1%. The experimental application showed the scale is user-friendly. the scale presents valid content for the assessment of fall risk and risk of fall-related injuries and is easy to use, with the potential to contribute to the proper identification of risks and the establishment of care actions. realizar a adaptação transcultural para uso no Brasil e a avaliação da validade de conteúdo da Johns Hopkins Fall Risk Assessment Tool para avaliação de risco de quedas e de danos <span class="hlt">por</span> quedas em pacientes adultos hospitalizados. adaptação transcultural consistiu na tradução da escala para a língua portuguesa (Brasil), retrotradução para a língua de origem, versão de consenso e análise da equivalência transcultural <span class="hlt">por</span> um comitê de especialistas. A avaliação do conteúdo foi realizada <span class="hlt">por</span> meio de um comitê de juízes, finalizando com o cálculo do índice de validade de conteúdo dos itens e da escala. Foi realizada a aplicação experimental do instrumento <span class="hlt">por</span> enfermeiros. a versão traduzida da escala passou <span class="hlt">por</span> duas rodadas de avaliação pelos juízes, a partir das quais os itens com desempenho insatisfatório foram modificados</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28737879','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28737879"><span>[Visceral leishmaniasis. Pediatric case report].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Gomila H, Andrés; Vanzo, Carolina; Garnero, Analía; Peruzzo, Luisina; Badalotti, Mónica</p> <p>2017-08-01</p> <p>La leishmaniasis es una enfermedad causada <span class="hlt">por</span> parásitos obligados intracelulares pertenecientes al género Leishmania y que reconoce tres formas clínicas principales: cutánea, visceral y mucocutánea. Es una patología del grupo de las "enfermedades desatendidas". Es la única enfermedad tropical transmitida a través de vectores que se ha mantenido endémica <span class="hlt">por</span> décadas en el sur de Europa. La leishmaniasis visceral representa la forma más grave. Se caracteriza <span class="hlt">por</span> fiebre, pérdida de peso, anemia y hepatoesplenomegalia. Su período de incubación oscila entre 2 semanas y 18 meses. La leishmaniasis se considera una enfermedad reemergente a nivel mundial. Algunos de los factores que favorecen esta situación son los cambios en las condiciones climáticas, migraciones y urbanizaciones deficitarias en saneamiento ambiental. Se presenta el caso de un niño europeo que estaba vacacionando en Córdoba y fue derivado a nuestro Hospital <span class="hlt">por</span> fiebre y pancitopenia, lo que generó un abordaje multidisciplinario con resolución clínica favorable. Sociedad Argentina de Pediatría.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29775033','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29775033"><span>Guidelines for Clinical Practice: Hymenoptera sting allergy in children: 2017 update</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p></p> <p>2017-10-01</p> <p>Las picaduras <span class="hlt">por</span> himenópteros son frecuentes en la infancia. La mayoría producen reacciones locales, consecuencia de un mecanismo inflamatorio, no alérgico, no tienen progresión y se resuelven con simples medidas terapéuticas. Las reacciones más extensas, generalmente, están asociadas a mecanismos alérgicos, mediados <span class="hlt">por</span> inmunoglobulina E. Su máxima expresión, la anafilaxia, presenta síntomas cutáneos, respiratorios, cardiovasculares, digestivos y/o neurológicos, con riesgo de muerte. La prevalencia de anafilaxia en pacientes con mastocitosis sistémica es más alta. La familia Hymenoptera, que incluye hormigas coloradas, abejas y avispas, es la causante de las picaduras de mayor riesgo, potencialmente fatales. Los pilares del diagnóstico son la historia clínica, la identificación del insecto, y las pruebas diagnósticas cutáneas y/o in vitro interpretadas <span class="hlt">por</span> el especialista en Alergia e Inmunología. La inmunoterapia con veneno es el tratamiento de elección para prevenir reacciones anafilácticas <span class="hlt">por</span> picaduras de himenópteros.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28350828','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28350828"><span>Clustering of four major lifestyle risk factors among Korean adults with metabolic syndrome.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ha, Shin; Choi, Hui Ran; Lee, Yo Han</p> <p>2017-01-01</p> <p>The purpose of this study was to investigate the clustering pattern of four major lifestyle risk factors-smoking, heavy drinking, poor diet, and physical inactivity-among people with metabolic syndrome in South Korea. There were 2,469 adults with metabolic syndrome aged 30 years or older available with the 5th Korean National Health and Nutrition Examination Survey dataset. We calculated the ratio of the observed to expected (O/E) prevalence for the 16 different combinations and the prevalence odds ratios (<span class="hlt">POR</span>) of four lifestyle risk factors. The four lifestyle risk factors tended to cluster in specific multiple combinations. Smoking and heavy drinking was clustered (<span class="hlt">POR</span>: 1.86 for male, 4.46 for female), heavy drinking and poor diet were clustered (<span class="hlt">POR</span>: 1.38 for male, 1.74 for female), and smoking and physical inactivity were also clustered (<span class="hlt">POR</span>: 1.48 for male). Those who were male, younger, low-educated and living alone were much more likely to have a higher number of lifestyle risk factors. Some helpful implications can be drawn from the knowledge on clustering pattern of lifestyle risk factors for more effective intervention program targeting metabolic syndrome.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22356303-crystallization-preliminary-crystallographic-analysis-selenomethionine-labelled-progesterone-reductase-from-digitalis-lanata-ehrh','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22356303-crystallization-preliminary-crystallographic-analysis-selenomethionine-labelled-progesterone-reductase-from-digitalis-lanata-ehrh"><span>Crystallization and preliminary crystallographic analysis of selenomethionine-labelled progesterone 5β-reductase from Digitalis lanata Ehrh</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Egerer-Sieber, Claudia; Herl, Vanessa; Müller-Uri, Frieder</p> <p>2006-03-01</p> <p>Progesterone 5β-reductase is the first stereospecific enzyme in the pathway for the synthesis of cardenolides. To elucidate the structural mechanism of this reaction, we crystallized the selenomethionine-labelled enzyme from D. lanata and report the preliminary analysis of a MAD data set collected from these crystals. Progesterone 5β-reductase (5β-<span class="hlt">POR</span>) catalyzes the reduction of progesterone to 5β-pregnane-3,20-dione and is the first stereospecific enzyme in the putative biosynthetic pathway of Digitalis cardenolides. Selenomethionine-derivatized 5β-<span class="hlt">POR</span> from D. lanata was successfully overproduced and crystallized. The crystals belong to space group P4{sub 3}2{sub 1}2, with unit-cell parameters a = 71.73, c = 186.64 Å. A MADmore » data set collected at 2.7 Å resolution allowed the identification of six out of eight possible Se-atom positions. A first inspection of the MAD-phased electron-density map shows that 5β-<span class="hlt">POR</span> is a Rossmann-type reductase and the quality of the map is such that it is anticipated that a complete atomic model of 5β-<span class="hlt">POR</span> will readily be built.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADB253648','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADB253648"><span>Increasing Access to Modern Multidisciplinary Breast Cancer Care</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>1999-08-01</p> <p>Hogan, Ed.M., Georgina De La Torre, B.A., Mary E. Avellone, Ph.D. Northwestern University Medical School Hispanics participate less in breast...Increasing Adherence to Physicians’ Screening Mammography 32-38 Recommendations Project 5: Mujeres Felices <span class="hlt">por</span> ser Saludables: Happy Healthy Women. A...availability: Results of a controlled clinical trial. Archives of Internal Medicine, 1999; 159:393-398. 38 PROJECT 5 - Mujeres Felices <span class="hlt">por</span> Ser Saludables</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2003cnam.conf...71M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2003cnam.conf...71M"><span>Estudio comparativo de las moléculas isovalentes de interés atmosférico CF3Cl y CF3Br y sus correspondientes halógenos aislados Cl y Br.</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Mayor, E.; Velasco, A. M.; Martín, I.; Lavín, C.</p> <p></p> <p>Los estados Rydberg moleculares han suscitado en los últimos años un creciente interés entre los espectroscopistas experimentales, motivado en parte <span class="hlt">por</span> el desarrollo de nuevas técnicas espectroscópicas capaces de investigar estos estados altamente excitados electrónicamente. Los procesos de fotoabsorción que implican estados Rydberg en los derivados halogenados del metano son de gran importancia, debido a su abundancia en la atmósfera y a sus implicaciones medioambientales. <span class="hlt">Por</span> ello, la obtención de datos relativos a sus fuerzas de oscilador es de gran interés. En este trabajo se aborda el estudio de dichas propiedades para las moléculas isovalentes CF3Cl y CF3Br. Ambas moléculas presentan idéntica estructura electrónica para el estado fundamental <span class="hlt">por</span> lo que se espera que sus espectros Rydberg presenten grandes similitudes, en ausencia de perturbaciones. <span class="hlt">Por</span> ello y dada la escasez de datos relativos a fuerzas de oscilador, hemos establecido la corrección de nuestros resultados en base a las analogías esperadas en las intensidades espectrales correspondientes a transiciones análogas. <span class="hlt">Por</span> otro lado, Novak y col. [1] han encontrado experimentalmente un marcado carácter atómico en el espectro correspondiente a estas moléculas, siendo muy similar a los de los átomos de Cl y Br. <span class="hlt">Por</span> ello en el presente trabajo, además de establecer la comparación entre ambas moléculas hemos buscado las similitudes con sus respectivos halógenos. Los cálculos relativos a las especies moleculares se han realizado utilizando la Metodología Molécular de Orbítales de Defecto Cuántico (MQDO) [2], mientras que para el estudio de los átomos de Cl y Br se empleó la versión relativista del método (RQDO) [3].</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22357138','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22357138"><span>Indoor air pollutants and health in the United Arab Emirates.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Yeatts, Karin B; El-Sadig, Mohamed; Leith, David; Kalsbeek, William; Al-Maskari, Fatma; Couper, David; Funk, William E; Zoubeidi, Taoufik; Chan, Ronna L; Trent, Chris B; Davidson, Christopher A; Boundy, Maryanne G; Kassab, Maamoon M; Hasan, Mohamed Y; Rusyn, Ivan; Gibson, Jacqueline MacDonald; Olshan, Andrew F</p> <p>2012-05-01</p> <p>Comprehensive global data on the health effects of indoor air pollutants are lacking. There are few large population-based multi-air pollutant health assessments. Further, little is known about indoor air health risks in the Middle East, especially in countries undergoing rapid economic development. To provide multifactorial indoor air exposure and health data, we conducted a population-based study of indoor air pollution and health in the United Arab Emirates (UAE). We conducted a cross-sectional study in a population-based sample of 628 households in the UAE. Indoor air pollutants [sulfur dioxide (SO2), nitrogen dioxide (NO2), hydrogen sulfide (H2S), formaldehyde (HCHO), carbon monoxide (CO), and particulate matter] were measured using passive samplers over a 7-day period. Health information was collected from 1,590 household members via in-person interviews. Participants in households with quantified SO2, NO2, and H2S (i.e., with measured concentrations above the limit of quantification) were twice as likely to report doctor-diagnosed asthma. Participants in homes with quantified SO2 were more likely to report wheezing symptoms {ever wheezing, prevalence odds ratio [<span class="hlt">POR</span>] 1.79 [95% confidence interval (CI) 1.05, 3.05]; speech-limiting wheeze, <span class="hlt">POR</span> 3.53 (95% CI: 1.06, 11.74)}. NO2 and H2S were similarly associated with wheezing symptoms. Quantified HCHO was associated with neurologic symptoms (difficulty concentrating <span class="hlt">POR</span> 1.47; 95% CI: 1.02, 2.13). Burning incense daily was associated with increased headaches (<span class="hlt">POR</span> 1.87; 95% CI: 1.09, 3.21), difficulty concentrating (<span class="hlt">POR</span> 3.08; 95% CI: 1.70, 5.58), and forgetfulness (<span class="hlt">POR</span> 2.68: 95% CI: 1.47, 4.89). This study provides new information regarding potential health risks from pollutants commonly found in indoor environments in the UAE and other countries. Multipollutant exposure and health assessments in cohort studies are needed to better characterize health effects of indoor air pollutants.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012PhDT.......480M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012PhDT.......480M"><span>Atomic layer deposition of metal oxide by non-aqueous sol-gel chemistry =</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Marichy, Catherine</p> <p></p> <p>O trabalho apresentado neste manuscrito foi desenvolvido no ambito do programa doutoral intitulado “Deposicao de Camadas Atomicas (ALD) de oxido de metais <span class="hlt">por</span> sol-gel nao-aquoso”. O objectivo deste trabalho foi a preparacao de hetero-estruturas funcionais <span class="hlt">por</span> ALD e a sua caracterizacao. Foi desenvolvido um novo processo de deposicao de oxido de estanho a temperatura baixa-moderada, utilizando um metodo ALD nao-aquoso, o qual foi aplicado com sucesso ao revestimento controlado das paredes internas e externas de nanotubos de carbono. Uma vez que a preparacao de nanomateriais funcionais requer uma elevada exatidao do processo de deposicao, foi demonstrada a deposicao precisa de filmes que se adaptem a forma do substrato ou de filmes nano-estruturados constituidos <span class="hlt">por</span> particulas em varios substratos. Alem disso, foram depositados com grande exatidao varios oxidos de metal em nanotubos de carbono e demonstrou-se a possibilidade de ajustar o revestimento feito <span class="hlt">por</span> ALD atraves do controlo da funcionalizacao da superficie do substrato nano-estruturado de carbono. As hetero-estruturas obtidas foram posteriormente aplicadas como sensores de gases. O melhoramento verificado na sensibilidade foi atribuido a formacao de heterojuncoes p-n entre o filme de oxido de metais e o suporte. O trabalho desenvolvido tendo como objetivo o controlo do revestimento <span class="hlt">por</span> ALD atraves da funcionalizacao da superficie do suporte e certamente de interesse para o design de hetero-estruturas funcionais baseadas em substratos de carbono. De facto, durante o ultimo periodo do programa de doutoramento, este conceito foi alargado a funcionalizacao e revestimento com oxidos de metal de fibras de carbono preparadas <span class="hlt">por</span> “electrospinning”, de forma a melhorar a estabilidade e a atividade eletrocatalitica de catalisadores a base de Pt. Este trabalho foi realizado maioritariamente na Universidade de Aveiro mas tambem na Universidade Nacional de Seul e beneficiou de varias colaboracoes internacionais</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3021240','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3021240"><span>Flavobacterium johnsoniae sprB Is Part of an Operon Spanning the Additional Gliding Motility Genes sprC, sprD, and sprF ▿ †</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Rhodes, Ryan G.; Nelson, Shawn S.; Pochiraju, Soumya; McBride, Mark J.</p> <p>2011-01-01</p> <p>Cells of Flavobacterium johnsoniae move rapidly over surfaces by a process known as gliding motility. Gld proteins are thought to comprise the gliding motor that propels cell surface adhesins, such as the 669-kDa SprB. A novel protein secretion apparatus called the <span class="hlt">Por</span> secretion system (<span class="hlt">Por</span>SS) is required for assembly of SprB on the cell surface. Genetic and molecular analyses revealed that sprB is part of a seven-gene operon spanning 29.3 kbp of DNA. In addition to sprB, three other genes of this operon (sprC, sprD, and sprF) are involved in gliding. Mutations in sprB, sprC, sprD, and sprF resulted in cells that failed to form spreading colonies on agar but that exhibited some motility on glass in wet mounts. SprF exhibits some similarity to Porphyromonas gingivalis <span class="hlt">Por</span>P, which is required for secretion of gingipain protease virulence factors via the P. gingivalis <span class="hlt">Por</span>SS. F. johnsoniae sprF mutants produced SprB protein but were defective in localization of SprB to the cell surface, suggesting a role for SprF in secretion of SprB. The F. johnsoniae <span class="hlt">Por</span>SS is involved in secretion of extracellular chitinase in addition to its role in secretion of SprB. SprF was not needed for chitinase secretion and may be specifically required for SprB secretion by the <span class="hlt">Por</span>SS. Cells with nonpolar mutations in sprC or sprD produced and secreted SprB and propelled it rapidly along the cell surface. Multiple paralogs of sprB, sprC, sprD, and sprF are present in the genome, which may explain why mutations in sprB, sprC, sprD, and sprF do not result in complete loss of motility and suggests the possibility that semiredundant SprB-like adhesins may allow movement of cells over different surfaces. PMID:21131497</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3346777','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3346777"><span>Indoor Air Pollutants and Health in the United Arab Emirates</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>El-Sadig, Mohamed; Leith, David; Kalsbeek, William; Al-Maskari, Fatma; Couper, David; Funk, William E.; Zoubeidi, Taoufik; Chan, Ronna L.; Trent, Chris B.; Davidson, Christopher A.; Boundy, Maryanne G.; Kassab, Maamoon M.; Hasan, Mohamed Y.; Rusyn, Ivan; Gibson, Jacqueline MacDonald; Olshan, Andrew F.</p> <p>2012-01-01</p> <p>Background: Comprehensive global data on the health effects of indoor air pollutants are lacking. There are few large population-based multi–air pollutant health assessments. Further, little is known about indoor air health risks in the Middle East, especially in countries undergoing rapid economic development. Objectives: To provide multifactorial indoor air exposure and health data, we conducted a population-based study of indoor air pollution and health in the United Arab Emirates (UAE). Methods: We conducted a cross-sectional study in a population-based sample of 628 households in the UAE. Indoor air pollutants [sulfur dioxide (SO2), nitrogen dioxide (NO2), hydrogen sulfide (H2S), formaldehyde (HCHO), carbon monoxide (CO), and particulate matter] were measured using passive samplers over a 7-day period. Health information was collected from 1,590 household members via in-person interviews. Results: Participants in households with quantified SO2, NO2, and H2S (i.e., with measured concentrations above the limit of quantification) were twice as likely to report doctor-diagnosed asthma. Participants in homes with quantified SO2 were more likely to report wheezing symptoms {ever wheezing, prevalence odds ratio [<span class="hlt">POR</span>] 1.79 [95% confidence interval (CI) 1.05, 3.05]; speech-limiting wheeze, <span class="hlt">POR</span> 3.53 (95% CI: 1.06, 11.74)}. NO2 and H2S were similarly associated with wheezing symptoms. Quantified HCHO was associated with neurologic symptoms (difficulty concentrating <span class="hlt">POR</span> 1.47; 95% CI: 1.02, 2.13). Burning incense daily was associated with increased headaches (<span class="hlt">POR</span> 1.87; 95% CI: 1.09, 3.21), difficulty concentrating (<span class="hlt">POR</span> 3.08; 95% CI: 1.70, 5.58), and forgetfulness (<span class="hlt">POR</span> 2.68: 95% CI: 1.47, 4.89). Conclusions: This study provides new information regarding potential health risks from pollutants commonly found in indoor environments in the UAE and other countries. Multipollutant exposure and health assessments in cohort studies are needed to better characterize health effects</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1996BAAA...40....1R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1996BAAA...40....1R"><span>Astronomía Gamma desde El Leoncito</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Rovero, A. C.; Colombo, E.; Sahade, J.; Weekes, T. C.</p> <p></p> <p>La astronomía gamma, en el extremo de energías detectadas hasta el presente, se encuentra en desarrollo en muchas partes del mundo y proporciona resultados sorprendentes a medida que la tecnología avanza en el desarrollo de nuevos detectores. La técnica Cherenkov Atmosférica es la utilizada para la detección, mediante telescopios en tierra, del efecto secundario causado <span class="hlt">por</span> la radiación gamma de muy altas energías (E ≈ TeV). <span class="hlt">Por</span> medio de telescopios o arreglos de detectores y utilizando la técnica mencionada, se han podido detectar algunas fuentes puntuales de mucha importancia astrofísica como la Nebulosa del Cangrejo y la galaxia de núcleo activo Markarian 421. El sistema instalado en San Juan, en cooperación con el grupo de Radiación Gamma del Observatorio Whipple, está constituído <span class="hlt">por</span> tres colectores de 1.5m que registran pulsos de luz generados <span class="hlt">por</span> las cascadas de partículas producidas <span class="hlt">por</span> rayos cósmicos de todo tipo al entrar en la atmósfera terrestre. El sistema opera <span class="hlt">por</span> barrido en ascención recta de la fuente observada que, para esta etapa del experimento, es el Centro Galáctico. Esta fuente extensa es conocida como emisor gamma de energías inferiores al TeV y ha sido observada anteriormente en este rango de energía desde el hemisferio norte pero con elevaciones bajas, situación no óptima para este tipo de técnica. Se presentan los primeros resultados del análisis de los datos obtenidos observando la región del Centro Galáctico, luego de dos años de observaciones, así como una descripción de la técnica Cherenkov Atmosférica y del equipo utilizado en la experiencia.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28429931','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28429931"><span>Heterobimetallic Nitrido Complexes of Group 8 Metalloporphyrins.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cheung, Wai-Man; Chiu, Wai-Hang; de Vere-Tucker, Matthew; Sung, Herman H-Y; Williams, Ian D; Leung, Wa-Hung</p> <p>2017-05-15</p> <p>Heterobimetallic nitrido porphyrin complexes with the [(L)(<span class="hlt">por</span>)M-N-M'(L OEt )Cl 2 ] formula {<span class="hlt">por</span> 2- = 5,10,15,20-tetraphenylporphyrin (TPP 2- ) or 5,10,15,20-tetra(p-tolyl)porphyrin (TTP 2- ) dianion; L OEt - = [Co(η 5 -C 5 H 5 ){P(O)(OEt) 2 } 3 ] - ; M = Fe, Ru, or Os; M' = Ru or Os; L = H 2 O or pyridine} have been synthesized, and their electrochemistry has been studied. Treatment of trans-[Fe(TPP)(py) 2 ] (py = pyridine) with Ru(VI) nitride [Ru(L OEt )(N)Cl 2 ] (1) afforded Fe/Ru μ-nitrido complex [(py)(TPP)Fe(μ-N)Ru(L OEt )Cl 2 ] (2). Similarly, Fe/Os analogue [(py)(TPP)Fe(μ-N)Os(L OEt )Cl 2 ] (3) was obtained from trans-[Fe(TPP)(py) 2 ] and [Os(L OEt )(N)Cl 2 ]. However, no reaction was found between trans-[Fe(TPP)(py) 2 ] and [Re(L OEt )(N)Cl(PPh 3 )]. Treatment of trans-[M(TPP)(CO)(EtOH)] with 1 afforded μ-nitrido complexes [(H 2 O)(TPP)M(μ-N)Ru(L OEt )Cl 2 ] [M = Ru (4a) or Os (5)]. TTP analogue [(H 2 O)(TTP)Ru(μ-N)Ru(L OEt )Cl 2 ] (4b) was prepared similarly from trans-[Ru(TTP)(CO)(EtOH)] and 1. Reaction of [(H 2 O)(<span class="hlt">por</span>)M(μ-N)M(L OEt )Cl 2 ] with pyridine gave adducts [(py)(<span class="hlt">por</span>)M(μ-N)Ru(L OEt )Cl 2 ] [<span class="hlt">por</span> = TTP, and M = Ru (6); <span class="hlt">por</span> = TPP, and M = Os (7)]. The diamagnetism and short (<span class="hlt">por</span>)M-N(nitride) distances in 2 [Fe-N, 1.683(3) Å] and 4b [Ru-N, 1.743(3) Å] are indicative of the M IV ═N═M' IV bonding description. The cyclic voltammograms of the Fe/Ru (2) and Ru/Ru (4b) complexes in CH 2 Cl 2 displayed oxidation couples at approximately +0.29 and +0.35 V versus Fc +/0 (Fc = ferrocene) that are tentatively ascribed to the oxidation of the {L OEt Ru} and {Ru(TTP)} moieties, respectively, whereas the Fe/Os (3) and Os/Ru (5) complexes exhibited Os-centered oxidation at approximately -0.06 and +0.05 V versus Fc +/0 , respectively. The crystal structures of 2 and 4b have been determined.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3987293','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3987293"><span>Como Lo Hago Yo: Anomalías del Tubo Neural en Guatemala — Mielomeningocele Unidad de Espina Bífida e Hidrocefalia</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Manucci, Graciela; von Quednow, Enzo</p> <p>2014-01-01</p> <p>En Guatemala nacen <span class="hlt">por</span> añ 786 niños con defectos de tubo neural. Operamos 65 a 70 niños con mielomenigocele <span class="hlt">por</span> año. Tenemos equipo multidisciplinario. Recomendamos parto <span class="hlt">por</span> cesárea. Infección antes de la cirugía es un problema mayor. Derivación tardía es un problema. Disecamos la plaqueta con la técnica clásica. Suturamos la plaqueta para restituir la forma de la médula. Corpectomía en casos de cifósis. Hidrocefalía: Operamos el 80% de los niños. Chiari II: Operamos basados en los síntomas, primero nos aseguramos que la válvula funciona bien. Médula anclada: Operamos basados en los síntomas. PMID:24791216</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_23 --> <div id="page_24" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="461"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ctio.noao.edu/noao/content/UPDATE-MAJOR-EARTHQUAKE-CHILE-1','SCIGOVWS'); return false;" href="http://www.ctio.noao.edu/noao/content/UPDATE-MAJOR-EARTHQUAKE-CHILE-1"><span>UPDATE: MAJOR EARTHQUAKE IN CHILE (II) | CTIO</span></a></p> <p><a target="_blank" href="http://www.science.gov/aboutsearch.html">Science.gov Websites</a></p> <p></p> <p></p> <p>ciudad de Illapel a mitad de camino entre La Serena <em>y</em> Santiago. Esto fue seguido <span class="hlt">por</span> un tsunami que en el posterior tsunami. Algunos tienen casas en las partes bajas de La Serena <em>y</em> Coquimbo <em>y</em> tuvieron que evacuar <span class="hlt">por</span> la noche después de la alerta de tsunami, <em>y</em> algunos han sufrido daños en sus casas o</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26024576','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26024576"><span>Short Personality and Life Event scale for detection of suicide attempters.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Artieda-Urrutia, Paula; Delgado-Gómez, David; Ruiz-Hernández, Diego; García-Vega, Juan Manuel; Berenguer, Nuria; Oquendo, Maria A; Blasco-Fontecilla, Hilario</p> <p>2015-01-01</p> <p>To develop a brief and reliable psychometric scale to identify individuals at risk for suicidal behaviour. Case-control study. 182 individuals (61 suicide attempters, 57 psychiatric controls, and 64 psychiatrically healthy controls) aged 18 or older, admitted to the Emergency Department at Puerta de <span class="hlt">Hierro</span> University Hospital in Madrid, Spain. All participants completed a form including their socio-demographic and clinical characteristics, and the Personality and Life Events scale (27 items). To assess Axis I diagnoses, all psychiatric patients (including suicide attempters) were administered the Mini International Neuropsychiatric Interview. Descriptive statistics were computed for the socio-demographic factors. Additionally, χ(2) independence tests were applied to evaluate differences in socio-demographic and clinical variables, and the Personality and Life Events scale between groups. A stepwise linear regression with backward variable selection was conducted to build the Short Personality Life Event (S-PLE) scale. In order to evaluate the accuracy, a ROC analysis was conducted. The internal reliability was assessed using Cronbach's α, and the external reliability was evaluated using a test-retest procedure. The S-PLE scale, composed of just 6 items, showed good performance in discriminating between medical controls, psychiatric controls and suicide attempters in an independent sample. For instance, the S-PLE scale discriminated between past suicide and past non-suicide attempters with sensitivity of 80% and specificity of 75%. The area under the ROC curve was 88%. A factor analysis extracted only one factor, revealing a single dimension of the S-PLE scale. Furthermore, the S-PLE scale provides values of internal and external reliability between poor (test-retest: 0.55) and acceptable (Cronbach's α: 0.65) ranges. Administration time is about one minute. The S-PLE scale is a useful and accurate instrument for estimating the risk of suicidal behaviour in</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2008AsBio...8..967B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2008AsBio...8..967B"><span>Science Results from a Mars Drilling Simulation (Río Tinto, Spain) and Ground Truth for Remote Science Observations</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bonaccorsi, Rosalba; Stoker, Carol R.</p> <p>2008-10-01</p> <p>Science results from a field-simulated lander payload and post-mission laboratory investigations provided "ground truth" to interpret remote science observations made as part of the 2005 Mars Astrobiology Research and Technology Experiment (MARTE) drilling mission simulation. The experiment was successful in detecting evidence for life, habitability, and preservation potential of organics in a relevant astrobiological analogue of Mars. Science results. Borehole 7 was drilled near the Río Tinto headwaters at Peña de <span class="hlt">Hierro</span> (Spain) in the upper oxidized remnant of an acid rock drainage system. Analysis of 29 cores (215 cm of core was recovered from 606 cm penetrated depth) revealed a matrix of goethite- (42-94%) and hematite-rich (47-87%) rocks with pockets of phyllosilicates (47-74%) and fine- to coarse-grained loose material. Post-mission X-ray diffraction (XRD) analysis confirmed the range of hematite:goethite mixtures that were visually recognizable (˜1:1, ˜1:2, and ˜1:3 mixtures displayed a yellowish-red color whereas 3:1 mixtures displayed a dark reddish-brown color). Organic carbon was poorly preserved in hematite/goethite-rich materials (Corg <0.05 wt %) beneath the biologically active organic-rich soil horizon (Corg ˜3-11 wt %) in contrast to the phyllosilicate-rich zones (Corg ˜0.23 wt %). Ground truth vs. remote science analysis. Laboratory-based analytical results were compared to the analyses obtained by a Remote Science Team (RST) using a blind protocol. Ferric iron phases, lithostratigraphy, and inferred geologic history were correctly identified by the RST with the exception of phyllosilicate-rich materials that were misinterpreted as weathered igneous rock. Adenosine 5‧-triphosphate (ATP) luminometry, a tool available to the RST, revealed ATP amounts above background noise, i.e., 278-876 Relative Luminosity Units (RLUs) in only 6 cores, whereas organic carbon was detected in all cores. Our manned vs. remote observations based on automated</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005SEG....75..781J','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005SEG....75..781J"><span>Using TEM for sounding conductive and deep groundwater in Mars analog environments: Comparing two field studies</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Jernsletten, J. A.</p> <p>2005-11-01</p> <p>A TEM survey was carried out in Pima County, Arizona, in January 2003. Data was collected using 100 m Tx loops and a ferrite-cored magnetic coil Rx antenna, using a 16 Hz sounding frequency, which is sensitive to slightly salty groundwater. Prominent features in the data are the ~500 m depth of investigation and the ~120 m depth to the water table, confirmed by data from four USGS test wells sur-rounding the field area. Note also the conductive (~20-40 Ωm) clay-rich soil above the water table. During May and June of 2003, a Fast-Turnoff (early time) TEM survey was carried out at the Peña de <span class="hlt">Hierro</span> field area of the MARTE project, near the town of Nerva, Spain. Data was collected using 20 m and 40 m Tx loop antennae and 10 m loop Rx antennae, with a 32 Hz sounding frequency. Data from Line 4 (of 16) from this survey, collected using 40 m Tx loops, show ~200 m depth of investigation and a conduc-tive high at ~90 m depth below Station 20 (second station of 10 along this line). This is the water table, matching the 431 m MSL elevation of the nearby pit lake. Data from Line 15 and Line 14 of the Rio Tinto survey, collected using 20 m Tx loops, achieve ~50 m depth of investigation and show con-ductive highs at ~15 m depth below Station 50 (Line 15) and Station 30 (Line 14), interpreted as subsurface water flow under mine tailings matching surface flows seen coming out from under the tailings, and shown on maps. Both of the interpretations from Rio Tinto data (Line 4, and Lines 15 & 14) were confirmed by preliminary results from the MARTE ground truth drilling campaign carried out in September and October 2003. Drill Site 1 was moved ~50 m based on recommendations built on data from Line 15 and Line 14 of the Fast-Turnoff TEM survey.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017EGUGA..1914005G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017EGUGA..1914005G"><span>Improving GNSS time series for volcano monitoring: application to Canary Islands (Spain)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>García-Cañada, Laura; Sevilla, Miguel J.; Pereda de Pablo, Jorge; Domínguez Cerdeña, Itahiza</p> <p>2017-04-01</p> <p>The number of permanent GNSS stations has increased significantly in recent years for different geodetic applications such as volcano monitoring, which require a high precision. Recently we have started to have coordinates time series long enough so that we can apply different analysis and filters that allow us to improve the GNSS coordinates results. Following this idea we have processed data from GNSS permanent stations used by the Spanish Instituto Geográfico Nacional (IGN) for volcano monitoring in Canary Islands to obtained time series by double difference processing method with Bernese v5.0 for the period 2007-2014. We have identified the characteristics of these time series and obtained models to estimate velocities with greater accuracy and more realistic uncertainties. In order to improve the results we have used two kinds of filters to improve the time series. The first, a spatial filter, has been computed using the series of residuals of all stations in the Canary Islands without an anomalous behaviour after removing a linear trend. This allows us to apply this filter to all sets of coordinates of the permanent stations reducing their dispersion. The second filter takes account of the temporal correlation in the coordinate time series for each station individually. A research about the evolution of the velocity depending on the series length has been carried out and it has demonstrated the need for using time series of at least four years. Therefore, in those stations with more than four years of data, we calculated the velocity and the characteristic parameters in order to have time series of residuals. This methodology has been applied to the GNSS data network in El <span class="hlt">Hierro</span> (Canary Islands) during the 2011-2012 eruption and the subsequent magmatic intrusions (2012-2014). The results show that in the new series it is easier to detect anomalous behaviours in the coordinates, so they are most useful to detect crustal deformations in volcano monitoring.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/18629690','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/18629690"><span>Total dietary intake of mercury in the Canary Islands, Spain.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rubio, C; Gutiérrez, A; Burgos, A; Hardisson, A</p> <p>2008-08-01</p> <p>Estimating the risk associated with dietary intake of heavy metals by consumers is a vital and integral part of regulatory processes. The assessment of exposure to mercury shown in this paper has been performed by means of a study on the whole diet. Total mercury (Hg) levels were determined by cold vapour atomic absorption spectrometry (AAS) in 420 samples of regularly consumed food and drink. The total Hg concentrations measured in the different groups of food ranged from non-detectable to 119 microg kg(-1) w/w. The fish group had the highest concentrations of total Hg. All groups of food with regulated Hg content showed levels that were lower than the legally set values. The food consumption data used in the analysis were taken from the latest nutritional survey made in the Canary Islands, Spain. The estimated total Hg intake of local population (5.7 microg/person day(-1)) did not exceed the provisional tolerable weekly intake (PTWI) limit of 0.3 mg week(-1) of total mercury (43 microg/person day(-1)) fixed by the Joint Food and Agricultural Organization/World Health Organization (FAO/WHO) Expert Committee on Food Additives. Fishery products contributed 96% of the total Hg intake. The mean Hg intake for each island in this archipelago, formed by seven, has also been calculated. Fuerteventura, Lanzarote and El <span class="hlt">Hierro</span> are the islands with the highest level of Hg intake (7.0, 7,0 and 6.1 microg/person day(-1), respectively). La Palma Island, due to its low fish consumption, had the lowest level of Hg intake (4.5 microg/person day(-1)), followed by La Gomera (5.4 microg/person day(-1)), Tenerife (5.5 microg/person day(-1)) and Gran Canaria (5.6 microg/person day(-1)). A comparison has been made of the results obtained in this study with those found for other national and international communities.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5344021','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5344021"><span>True’s beaked whale (Mesoplodon mirus) in Macaronesia</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Martín, Vidal; Silva, Monica; Edler, Roland; Reyes, Cristel; Carrillo, Manuel; Schiavi, Agustina; Morales, Talia; García-Ovide, Belen; Sanchez-Mora, Anna; Garcia-Tavero, Nerea; Steiner, Lisa; Scheer, Michael; Gockel, Roland; Walker, Dylan; Villa, Enrico; Szlama, Petra; Eriksson, Ida K.; Tejedor, Marisa; Perez-Gil, Monica; Quaresma, João; Bachara, Wojtek; Carroll, Emma</p> <p>2017-01-01</p> <p>The True’s beaked whale (Mesoplodon mirus, True 1913) is a poorly known member of the Ziphiidae family. Its distribution in the northern hemisphere is thought to be restricted to the temperate or warm temperate waters of the North Atlantic, while a few stranding records from the southern hemisphere suggest a wider and antitropical distribution, extending to waters from the Atlantic coast of Brazil to South Africa, Mozambique, Australia and the Tasman Sea coast of New Zealand. This paper (i) reports the first molecular confirmation of the occurrence of the True’s beaked whale at the southern limit of its distribution recorded in the northeast Atlantic: the Azores and Canary Islands (macaronesian ecoregion); (ii) describes a new colouration for this species using evidence from a whale with molecular species confirmation; and (iii) contributes to the sparse worldwide database of live sightings, including the first underwater video recording of this species and close images of a calf. Species identification was confirmed in two cases using mitochondrial DNA control region and cytochrome b gene markers: a subadult male True’s beaked whale that stranded in El <span class="hlt">Hierro</span>, Canary Islands, in November 2012, and a subadult male found floating dead near Faial, the Azores, in July 2004. The whale that stranded in the Canary Islands had a clearly delimited white area on its head, extending posteriorly from the tip of the beak to cover the blowhole dorsally and the gular grooves ventrally. This colouration contrasts with previous descriptions for the species and it may be rare, but it exemplifies the variability of the colouration of True’s beaked whales in the North Atlantic, further confirmed here by live sightings data. The recording of several observations of this species in deep but relatively coastal waters off the Azores and the Canary Islands suggests that these archipelagos may be unique locations to study the behaviour of the enigmatic True’s beaked whale. PMID</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28286714','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28286714"><span>True's beaked whale (Mesoplodon mirus) in Macaronesia.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Aguilar de Soto, Natacha; Martín, Vidal; Silva, Monica; Edler, Roland; Reyes, Cristel; Carrillo, Manuel; Schiavi, Agustina; Morales, Talia; García-Ovide, Belen; Sanchez-Mora, Anna; Garcia-Tavero, Nerea; Steiner, Lisa; Scheer, Michael; Gockel, Roland; Walker, Dylan; Villa, Enrico; Szlama, Petra; Eriksson, Ida K; Tejedor, Marisa; Perez-Gil, Monica; Quaresma, João; Bachara, Wojtek; Carroll, Emma</p> <p>2017-01-01</p> <p>The True's beaked whale ( Mesoplodon mirus , True 1913) is a poorly known member of the Ziphiidae family. Its distribution in the northern hemisphere is thought to be restricted to the temperate or warm temperate waters of the North Atlantic, while a few stranding records from the southern hemisphere suggest a wider and antitropical distribution, extending to waters from the Atlantic coast of Brazil to South Africa, Mozambique, Australia and the Tasman Sea coast of New Zealand. This paper (i) reports the first molecular confirmation of the occurrence of the True's beaked whale at the southern limit of its distribution recorded in the northeast Atlantic: the Azores and Canary Islands (macaronesian ecoregion); (ii) describes a new colouration for this species using evidence from a whale with molecular species confirmation; and (iii) contributes to the sparse worldwide database of live sightings, including the first underwater video recording of this species and close images of a calf. Species identification was confirmed in two cases using mitochondrial DNA control region and cytochrome b gene markers: a subadult male True's beaked whale that stranded in El <span class="hlt">Hierro</span>, Canary Islands, in November 2012, and a subadult male found floating dead near Faial, the Azores, in July 2004. The whale that stranded in the Canary Islands had a clearly delimited white area on its head, extending posteriorly from the tip of the beak to cover the blowhole dorsally and the gular grooves ventrally. This colouration contrasts with previous descriptions for the species and it may be rare, but it exemplifies the variability of the colouration of True's beaked whales in the North Atlantic, further confirmed here by live sightings data. The recording of several observations of this species in deep but relatively coastal waters off the Azores and the Canary Islands suggests that these archipelagos may be unique locations to study the behaviour of the enigmatic True's beaked whale.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29554983','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29554983"><span>Along for the ride or missing it altogether: exploring the host specificity and diversity of haemogregarines in the Canary Islands.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tomé, Beatriz; Pereira, Ana; Jorge, Fátima; Carretero, Miguel A; Harris, D James; Perera, Ana</p> <p>2018-03-19</p> <p>Host-parasite relationships are expected to be strongly shaped by host specificity, a crucial factor in parasite adaptability and diversification. Because whole host communities have to be considered to assess host specificity, oceanic islands are ideal study systems given their simplified biotic assemblages. Previous studies on insular parasites suggest host range broadening during colonization. Here, we investigate the association between one parasite group (haemogregarines) and multiple sympatric hosts (of three lizard genera: Gallotia, Chalcides and Tarentola) in the Canary Islands. Given haemogregarine characteristics and insular conditions, we hypothesized low host specificity and/or occurrence of host-switching events. A total of 825 samples were collected from the three host taxa inhabiting the seven main islands of the Canarian Archipelago, including locations where the different lizards occurred in sympatry. Blood slides were screened to assess prevalence and parasitaemia, while parasite genetic diversity and phylogenetic relationships were inferred from 18S rRNA gene sequences. Infection levels and diversity of haplotypes varied geographically and across host groups. Infections were found in all species of Gallotia across the seven islands, in Tarentola from Tenerife, La Gomera and La Palma, and in Chalcides from Tenerife, La Gomera and El <span class="hlt">Hierro</span>. Gallotia lizards presented the highest parasite prevalence, parasitaemia and diversity (seven haplotypes), while the other two host groups (Chalcides and Tarentola) harbored one haplotype each, with low prevalence and parasitaemia levels, and very restricted geographical ranges. Host-sharing of the same haemogregarine haplotype was only detected twice, but these rare instances likely represent occasional cross-infections. Our results suggest that: (i) Canarian haemogregarine haplotypes are highly host-specific, which might have restricted parasite host expansion; (ii) haemogregarines most probably reached the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19105754','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19105754"><span>Science results from a Mars drilling simulation (Río Tinto, Spain) and ground truth for remote science observations.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bonaccorsi, Rosalba; Stoker, Carol R</p> <p>2008-10-01</p> <p>Science results from a field-simulated lander payload and post-mission laboratory investigations provided "ground truth" to interpret remote science observations made as part of the 2005 Mars Astrobiology Research and Technology Experiment (MARTE) drilling mission simulation. The experiment was successful in detecting evidence for life, habitability, and preservation potential of organics in a relevant astrobiological analogue of Mars. SCIENCE RESULTS: Borehole 7 was drilled near the Río Tinto headwaters at Peña de <span class="hlt">Hierro</span> (Spain) in the upper oxidized remnant of an acid rock drainage system. Analysis of 29 cores (215 cm of core was recovered from 606 cm penetrated depth) revealed a matrix of goethite- (42-94%) and hematite-rich (47-87%) rocks with pockets of phyllosilicates (47-74%) and fine- to coarse-grained loose material. Post-mission X-ray diffraction (XRD) analysis confirmed the range of hematite:goethite mixtures that were visually recognizable (approximately 1:1, approximately 1:2, and approximately 1:3 mixtures displayed a yellowish-red color whereas 3:1 mixtures displayed a dark reddish-brown color). Organic carbon was poorly preserved in hematite/goethite-rich materials (C(org) <0.05 wt %) beneath the biologically active organic-rich soil horizon (C(org) approximately 3-11 wt %) in contrast to the phyllosilicate-rich zones (C(org) approximately 0.23 wt %). GROUND TRUTH VS. REMOTE SCIENCE ANALYSIS: Laboratory-based analytical results were compared to the analyses obtained by a Remote Science Team (RST) using a blind protocol. Ferric iron phases, lithostratigraphy, and inferred geologic history were correctly identified by the RST with the exception of phyllosilicate-rich materials that were misinterpreted as weathered igneous rock. Adenosine 5'-triphosphate (ATP) luminometry, a tool available to the RST, revealed ATP amounts above background noise, i.e., 278-876 Relative Luminosity Units (RLUs) in only 6 cores, whereas organic carbon was detected in all</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2010ems..confE.590H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2010ems..confE.590H"><span>Forecasting of Hourly Photovoltaic Energy in Canarian Electrical System</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Henriquez, D.; Castaño, C.; Nebot, R.; Piernavieja, G.; Rodriguez, A.</p> <p>2010-09-01</p> <p>The Canarian Archipelago face similar problems as most insular region lacking of endogenous conventional energy resources and not connected to continental electrical grids. A consequence of the "insular fact" is the existence of isolated electrical systems that are very difficult to interconnect due to the considerable sea depths between the islands. Currently, the Canary Islands have six isolated electrical systems, only one utility generating most of the electricity (burning fuel), a recently arrived TSO (REE) and still a low implementation of Renewable Energy Resources (RES). The low level of RES deployment is a consequence of two main facts: the weakness of the stand-alone grids (from 12 MW in El <span class="hlt">Hierro</span> up to only 1 GW in Gran Canaria) and the lack of space to install RES systems (more than 50% of the land protected due to environmental reasons). To increase the penetration of renewable energy generation, like solar or wind energy, is necessary to develop tools to manage them. The penetration of non manageable sources into weak grids like the Canarian ones causes a big problem to the grid operator. There are currently 104 MW of PV connected to the islands grids (Dec. 2009) and additional 150 MW under licensing. This power presents a serious challenge for the operation and stability of the electrical system. ITC, together with the local TSO (Red Eléctrica de España, REE) started in 2008 and R&D project to develop a PV energy prediction tool for the six Canarian Insular electrical systems. The objective is to supply reliable information for hourly forecast of the generation dispatch programme and to predict daily solar radiation patterns, in order to help program spinning reserves. ITC has approached the task of weather forecasting using different numerical model (MM5 and WRF) in combination with MSG (Meteosat Second Generation) images. From the online data recorded at several monitored PV plants and meteorological stations, PV nominal power and energy produced</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24897523','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24897523"><span>Self-reported adherence to medical treatment, breastfeeding behaviour, and disease activity during the postpartum period in women with Crohn's disease.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Julsgaard, Mette; Nørgaard, Mette; Hvas, Christian Lodberg; Grosen, Anne; Hasseriis, Sara; Christensen, Lisbet Ambrosius</p> <p>2014-08-01</p> <p>Adherence to medical treatment among women with Crohn's disease (CD) in the postpartum period has never been examined. The impact of breast-feeding on disease activity remains controversial. We aimed to assess rates of non-adherence to medical treatment among women with CD in the postpartum period. Further, to assess breast-feeding rates and the impact of breast-feeding on the risk of relapse. Within a population of 1.6 million, we identified 154 women with CD who had given birth within a 6-year period. We combined questionnaire data, data from medical records and public register data. We used logistic regression to estimate prevalence odds ratios (<span class="hlt">POR</span>) for non-adherence, relapse and breast-feeding according to different predictors. Among 105 (80%) respondents, 59 (56%) reported taking medication. Of these, 66.1% reported to be adherent to medical treatment. Fear of medication transmission to the breast milk was stated as the reason for non-adherence in 60%. Those who received counselling regarding medical treatment were less likely to be non-adherent (<span class="hlt">POR</span> 0.55, 95% confidence interval [CI] 0.1-2.5). In total, 87.6% were breast-feeding. Breast-feeding rates did not vary by medical treatment. Predictors for relapse in CD were smoking (<span class="hlt">POR</span> 1.85, 95% CI 0.62-5.54) and non-adherence among medical treated (<span class="hlt">POR</span> 1.25, 95% CI 0.26-6.00). Breast-feeding seemed protective against relapse (<span class="hlt">POR</span> 0.33, 95% CI 0.10-1.26). Adherence to medical treatment in the postpartum period was high, and counselling seemed to increase adherence. Relapse may be explained by non-adherence or smoking while breast-feeding seemed protective.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4542001','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4542001"><span>Gender Differences in Smoking Among U.S. Working Adults</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Syamlal, Girija; Mazurek, Jacek M.; Dube, Shanta R.</p> <p>2015-01-01</p> <p>Background Cigarette smoking remains a leading cause of morbidity and mortality. Although gender differences in cigarette smoking in the U.S. population have been documented, information on these differences among working adults is limited. Purpose To describe the current smoking prevalence by gender among working U.S. adults and examine gender differences in smoking by occupation. Methods The 2004–2011 National Health Interview Survey data for adults aged ≥18 years that were working in the week prior to the interview (N=132,215) were analyzed in 2013. Current cigarette smokers were those who smoked at least 100 cigarettes in their lifetime and currently smoke every day or some days. Results During 2004–2011, an estimated 22.8% of men workers and 18.3% of women workers were current smokers. Of the current smokers, women workers had higher odds of being an everyday smoker (prevalence OR [<span class="hlt">POR</span>]=1.17, 95% CI=1.09, 1.26); having poor self-rated emotional health (<span class="hlt">POR</span>=1.28, 95% CI=1.15, 1.41); and having chronic obstructive pulmonary disease (<span class="hlt">POR</span>=2.45, 95% CI=2.14, 2.80), heart disease (<span class="hlt">POR</span>=1.27, 95% CI=1.12, 1.45), and current asthma (<span class="hlt">POR</span>=2.21, 95% CI=1.96, 2.49) compared with men workers. Women in “supervisors, construction, and extraction” (38.9%) occupations and men in “extraction” (40.5%) occupations had the highest smoking prevalence. Conclusion Among working adults, women had lower prevalence of smoking than men, yet women who smoke were more likely than men to have adverse health outcomes, including self-rated poorer physical and emotional health. PMID:25049215</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/1065427-singlet-triplet-excitation-management-bichromophoric-near-infrared-phosphorescent-bodipy-benzoporphyrin-platinum-complex','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/1065427-singlet-triplet-excitation-management-bichromophoric-near-infrared-phosphorescent-bodipy-benzoporphyrin-platinum-complex"><span>Singlet and triplet excitation management in a bichromophoric near-infrared-phosphorescent BODIPY-benzoporphyrin platinum complex</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Whited, M. T.; Djurovich, P. I.; Roberts, Sean T.</p> <p>2011-01-12</p> <p>Multichromophoric arrays provide one strategy for assembling molecules with intense absorptions across the visible spectrum but are generally focused on systems that efficiently produce and manipulate singlet excitations and therefore are burdened by the restrictions of (a) unidirectional energy transfer and (b) limited tunability of the lowest molecular excited state. In contrast, we present here a multichromophoric array based on four boron dipyrrins (BODIPY) bound to a platinum benzoporphyrin scaffold that exhibits intense panchromatic absorption and efficiently generates triplets. The spectral complementarity of the BODIPY and porphryin units allows the direct observation of fast bidirectional singlet and triplet energy transfermore » processes (k ST( 1BDP→ 1<span class="hlt">Por</span>) = 7.8 × 10 11 s -1, k TT( 3Por→ 3BDP) = 1.0 × 10 10 s -1, k TT( 3BDP→ 3<span class="hlt">Por</span>) = 1.6 × 10 10 s -1), leading to a long-lived equilibrated [ 3BDP][<span class="hlt">Por</span>]⇌[BDP][ 3<span class="hlt">Por</span>] state. This equilibrated state contains approximately isoenergetic porphyrin and BODIPY triplets and exhibits efficient near-infrared phosphorescence (λ em = 772 nm, Φ = 0.26). Taken together, these studies show that appropriately designed triplet-utilizing arrays may overcome fundamental limitations typically associated with core-shell chromophores by tunable redistribution of energy from the core back onto the antennae.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2003BAAA...46...83M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2003BAAA...46...83M"><span>Edades relativas de cúmulos globulares</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Miller Bertolami, M.; Forte, J. C.</p> <p></p> <p>El trabajo de Rossemberg et al (1999), estudia las edades relativas de cúmulos globulares galácticos mediante el análisis de ciertos parámetros morfológicos de los diagramas color-magnitud de dichos cúmulos. Este trabajo se centra en tres puntos: analizar la consistencia de los resultados obtenidos <span class="hlt">por</span> Rossemberg et al (1999) al emplear observaciones en el sistema fotométrico de Washington, más precisamente, las magnitudes C y T1 en lugar de las magnitudes V e I utilizadas <span class="hlt">por</span> dichos autores. De la existencia de colores integrados, metalicidad y edad (relativa) para 21 de los cúmulos utilizados en dicho trabajo, se analiza la consistencia de estos resultados con las dependencias de color integrado como función de la edad y la metalicidad que se desprenden de los modelos teóricos de luz integrada <span class="hlt">por</span> Worthey (1994), Schulz (2002) y Lee et al (2002). <span class="hlt">Por</span> último se lleva a cabo una breve comparación de la morfología de los diagramas color-magnitud de los cúmulos globulares y de las isocronas utilizadas, a fin de intentar identificar algunas de las posibles causas de las diferencias observadas en los incisos anteriores.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1996BAAA...40...11G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1996BAAA...40...11G"><span>Resonancias en la región trans-neptuniana</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gallardo, T.; Ferraz-Mello, S.</p> <p></p> <p>La expansión de la órbita del planeta Neptuno en la etapa de acreción del Sistema Solar exterior (Fernández e Ip 1984, 1996) parece ser un mecanismo eficiente para la captura de planetesimales en las resonancias exteriores con Neptuno (Malhotra 1995). <span class="hlt">Por</span> otro lado, los estudios dinámicos realizados <span class="hlt">por</span> varios autores indican que las resonancias son regiones de evolución estable, en contraste con el comportamiento caótico del resto de la región trans-neptuniana. <span class="hlt">Por</span> estas razones, y si bien los datos observacionales son todavía muy limitados, se supone que los objetos descubiertos se encuentran en alguna de esas resonancias. En esta comunicación presentamos un estudio analítico y numérico de las principales resonancias exteriores con Neptuno.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2003BASBr..22...17C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2003BASBr..22...17C"><span>Buracos negros primordiais e astrofísica observacional</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Custódio, P. S.; Horvath, J. E.</p> <p>2003-02-01</p> <p>A história da física contemporânea é pródiga em grandes descobertas (a Relatividade e a Mecânica Quântica entre as mais importantes) até meados dos anos '30. O peso destes desenvolvimentos é tão grande que outros feitos de grande porte (<span class="hlt">por</span> exemplo, a teoria da nucleossíntese nas estrelas) são geralmente considerados como "filhotes" dos primeiros, ao menos na imaginação popular. <span class="hlt">Por</span>ém, algumas exceções à regra não-escrita são dignas de menção. Entre estas últimas está a descoberta <span class="hlt">por</span> S.W.Hawking e colaboradores das propriedades de emissão dos buracos negros, trabalho que iniciou uma disciplina com vida própria denominada Termodinâmica de Buracos Negros.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4138820','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4138820"><span>Síndrome del Outlet Torácico: ¿Una Patología Siempre Quirúrgica? Análisis de una Serie de 31 Cirugías Realizadas <span class="hlt">por</span> Vía Supraclavicular Serie clínica</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Socolovsky, Mariano; Di Masi, Gilda; Binaghi, Daniela; Campero, Álvaro; Páez, Miguel Domínguez; Dubrovsky, Alberto</p> <p>2014-01-01</p> <p>Introducción: El síndrome de outlet torácico es una compresión del plexo braquial que suscita polémica. Se clasifica en Outlet Torácico Verdadero o neurogénico (OTV) y Outlet Torácico Disputado o no neurogénico (OTD). El primero presenta síntomas motores en la mano, mientras que el segundo sólo síntomas sensitivos en el miembro superior. El objetivo de este trabajo es analizar los resultados obtenidos en una serie de 31 cirugías. Métodos: Se analizaron las cirugías de nervios efectuadas entre 2003-2012, tomando los diagnósticos de outlet torácico cuyo período de seguimiento post-operatorio mínimo fuera de 6 meses. Se buscaron los siguientes datos: edad, sexo, presencia de síntomas sensitivos y/o motores, clasificación, resultado de los estudios neurofisiológicos y de imágenes, resultado de la cirugía, complicaciones post-operatorias y recidivas. Resultados: Se incluyeron 31 cirugías realizadas en 30 pacientes, 9 OTV (8 mujeres) de 24.3 años, y 21 con OTD (18 mujeres) de 37.4 años de edad en promedio. Un 90% presentaron alteraciones neurofisiológicas preoperatorias, y 66,6% imagenológicas. En el intraoperatorio, el 100% de los OTV presentó una alteración anatómica relacionada con la sintomatología, hecho observado sólo en el 36.7% de los OTD operados. El 87,5% de los OTV mejoraron sensitivamente, mientras que 77,7% mejoraron la atrofia. <span class="hlt">Por</span> el contrario, 45.4% de los OTD mejoraron permanentemente, 36.3% no tuvieron cambios, 13.6% mejoraron transitoriamente y 4.5% (un caso) empeoró. Las complicaciones post-operatorias fueron más frecuentes aunque transitorias en el grupo de OTV (3 casos sobre 9 operados, 33.3%) que en los OTD (3 casos sobre 22, un 13.6%). Conclusión: El OTV suele mayormente mejorar luego de la cirugía, igual que el OTD aunque en una proporción mucho menor. Estos hallazgos coinciden con otros reportes recientes de esta patología. PMID:25165614</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA471901','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA471901"><span>DNA Vaccination of the American Crow (Corvus brachyrhynchos) Provides Partial Protection Against Lethal Challenge with West Nile Virus</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2007-01-01</p> <p>mortality but did not provide sterile immunity. RESUMEN. La vacunación del cuervo Americano (Corvus brachyrhynchos) con vacuna de ADN proporciona...casi 100% fatal en el cuervo Americano (Corvus brachyrhynchos). Evaluamos cuatro formulaciones de vacunas en cuervos Americanos, incluyendo una vacuna de...ADN, una vacuna de ADN con adyuvante, ambas aplicadas <span class="hlt">por</span> la vı́a intramuscular, una vacuna de ADN microencapsulada aplicada <span class="hlt">por</span> la vı́a oral, y una</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28000450','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28000450"><span></span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Soriguer, Federico</p> <p>2016-11-29</p> <p>Desde hace algún tiempo sabemos que la talla de las poblaciones es un buen instrumento para analizar la evolución socioeconómica, habiendo dejado de ser motivo de estudio solo <span class="hlt">por</span> la biomedicina para serlo también <span class="hlt">por</span> los economistas y sociólogos. Es lo que han hecho Martínez Carrión y cols., con el trabajo que aparece en este número de Nutrición Hospitalaria.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_24 --> <div id="page_25" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="481"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA995482','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA995482"><span>OPERATION DOMINIC. FISH BOWL SERIES. Project Officer’s Report. Project 8A.3. Close-In Thermal and X-Ray Vulnerability Measurements--Shots Blue Gill and King Fish</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>1985-09-01</p> <p>QDC hLt umi ^ <span class="hlt">POR</span>.2037 (WT-2037)(EX) VOLUME 1 EXTRACTED VERSION OPERATION DOMINIC, FISH BOWL SERIES Project Officer’s Report—Project 8A.3...Close-In Thermal and X-ray Vulnerability Measurements—Shots Blue Gill and King Fish F. D. Adams, Project Officer Flight Dynamics Laboratory Wright...version of <span class="hlt">POR</span>-2037 (WT-2037), Volume 1, OPERATION DOMINIC; Fish Bowl Series, Project 8A. 3. Approved for public release; distribution is unlimited</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011RELEA..12...57D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011RELEA..12...57D"><span>Basic Concepts of Astronomy: a Methodological Proposal. (Spanish Title: Conceptos Básicos de Astronomía: Una Propuesta Metodológica.) Conceitos Básicos de Astronomia: Uma Proposta Metodológica</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Darroz, Luiz Marcelo; Heineck, Renato; Samudio Pérez, Carlos Ariel</p> <p>2011-12-01</p> <p>In this report, the development of a methodological proposal which approaches basic concepts of astronomy-grounded pedagogically on Meaningful Learning is described. The proposal, which consists of four meetings, was developed by teachers and academics of the course of Professor in Physics of the University of Passo Fundo (UPF), through an extension course to a group of highschool students of a public school of the town of Passo Fundo, RS. The work was focused into basic concepts of astronomy. The signs of Meaningful Learning have been obtained by means of research and evaluation tools that were applied at the end of each meeting. The evaluation of the proposal has been conducted by means of a final questionnaire which was answered by the participants at the end ofthe development of activities. By means of the results obtained from the different instruments, and the comments made by the participants during the activities and by means of the high rates of approval obtained in the final questionnaire, we think that the proposal reached the established goals and it may be repeated with the certainty of success. En este relato se describe una propuesta de desarrollo metodológico que aborda conceptos básicos de astronomía fundamentada pedagógicamente en el Aprendizaje Significativo. La propuesta que comprende cuatro encuentros, fue desarrollada <span class="hlt">por</span> profesores y académicos del curso de Licenciatura en Física de la Universidad de Passo Fundo (UPF), a través de un curso de extensión para un grupo de Liceo del 6º año de una Escuela Pública de la ciudad de Passo Fundo/RS. El trabajo tuvo como eje principal los "conceptos básicos de astronomía". Los indicios de Aprendizaje Significativo fueron obtenidos <span class="hlt">por</span> instrumentos de pesquisa y evaluación, siempre aplicados después de cada encuentro. La evaluación de la propuesta fue hecha a través de un cuestionario final y contestado <span class="hlt">por</span> los participantes al finalizar el desarrollo de actividades. <span class="hlt">Por</span> los resultados</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28746526','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28746526"><span>The impact of asthma in Brazil: a longitudinal analysis of data from a Brazilian national database system.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cardoso, Thiago de Araujo; Roncada, Cristian; Silva, Emerson Rodrigues da; Pinto, Leonardo Araujo; Jones, Marcus Herbert; Stein, Renato Tetelbon; Pitrez, Paulo Márcio</p> <p>2017-01-01</p> <p>To present official longitudinal data on the impact of asthma in Brazil between 2008 and 2013. This was a descriptive study of data collected between 2008 and 2013 from an official Brazilian national database, including data on asthma-related number of hospitalizations, mortality, and hospitalization costs. A geographical subanalysis was also performed. In 2013, 2,047 people died from asthma in Brazil (5 deaths/day), with more than 120,000 asthma-related hospitalizations. During the whole study period, the absolute number of asthma-related deaths and of hospitalizations decreased by 10% and 36%, respectively. However, the in-hospital mortality rate increased by approximately 25% in that period. The geographic subanalysis showed that the northern/northeastern and southeastern regions had the highest asthma-related hospitalization and in-hospital mortality rates, respectively. An analysis of the states representative of the regions of Brazil revealed discrepancies between the numbers of asthma-related hospitalizations and asthma-related in-hospital mortality rates. During the study period, the cost of asthma-related hospitalizations to the public health care system was US$ 170 million. Although the numbers of asthma-related deaths and hospital admissions in Brazil have been decreasing since 2009, the absolute numbers are still high, resulting in elevated direct and indirect costs for the society. This shows the relevance of the burden of asthma in middle-income countries. Apresentar dados longitudinais oficiais sobre o impacto da asma no Brasil entre 2008 e 2013. Estudo descritivo de dados extraídos de um banco de dados do governo brasileiro entre 2008 e 2013, no qual foram analisados as hospitalizações e óbitos <span class="hlt">por</span> asma, bem como o custo das hospitalizações. Foi também realizada uma subanálise geográfica. Em 2013, 2.047 pessoas morreram de asma no Brasil (5 óbitos/dia), com mais de 120.000 hospitalizações <span class="hlt">por</span> asma. Durante o período de estudo, o n</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28198959','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28198959"><span>Intraoperative body temperature control: esophageal thermometer versus infrared tympanic thermometer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Poveda, Vanessa de Brito; Nascimento, Ariane de Souza</p> <p>2016-01-01</p> <p>To verify the correlation between temperature measurements performed using an infrared tympanic thermometer and an esophageal thermometer during the intraoperative period. A longitudinal study of repeated measures was performed including subjects aged 18 years or older undergoing elective oncologic surgery of the digestive system, with anesthesia duration of at least 1 hour. Temperature measurements were performed simultaneously by a calibrated esophageal thermometer and by a calibrated infrared tympanic thermometer, with laboratory reading precision of ±0.2ºC. The operating room temperature remained between 19 and 21ºC. The study included 51 patients, mostly men (51%), white (80.4%). All patients were kept warm by a forced-air heating system, for an average of 264.14 minutes (SD = 87.7). The two temperature measurements showed no different behavior over time (p = 0.2205), however, tympanic measurements were consistently 1.24°C lower (p<0.0001). The tympanic thermometer presented reliable results but reflected lower temperatures than the esophageal thermometer. Verificar a correlação entre as medidas de temperatura realizadas <span class="hlt">por</span> meio de um termômetro timpânico <span class="hlt">por</span> infravermelho e <span class="hlt">por</span> um termômetro esofágico, durante o período intraoperatório. Realizou-se um estudo longitudinal, de medidas repetidas, incluindo sujeitos com idade igual ou superior a 18 anos, submetidos à cirurgia oncológica eletiva do sistema digestório, com duração da anestesia de, no mínimo, 1 hora. As medidas de temperatura eram realizadas, ao mesmo tempo, <span class="hlt">por</span> meio de um termômetro esofágico calibrado e <span class="hlt">por</span> termômetro timpânico <span class="hlt">por</span> infravermelho calibrado, com precisão de leitura em laboratório de ±0,2ºC. A temperatura da sala operatória permaneceu entre 19 e 21ºC. Foram incluídos 51 pacientes, em sua maioria homens (51%), brancos (80,4%). Todos os pacientes foram aquecidos com o sistema de ar forçado aquecido, em média <span class="hlt">por</span> 264,14 minutos (DP = 87,7). As duas</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/11282049','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/11282049"><span>[Variability in the in-hospital management of acute myocardial infarction in Spain. IBERICA Study (Investigación, Búsqueda Específica y Registro de Isquemia Coronaria <span class="hlt">Aguda</span>)].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Fiol, M; Cabadés, A; Sala, J; Marrugat, J; Elosua, R; Vega, G; José Tormo Díaz, M; Segura, A; Aldasoro, E; Moreno-Iribas, C; Muñiz, J; Hurtado de Saracho, I; García, J</p> <p>2001-04-01</p> <p>Introduction and objective. Although some in-hospital studies have described the management of acute myocardial infarction (MI) patients in Spain, none has been able to guarantee the exhaustiveness of patient registry. This study sought to determine the clinical characteristics and in-hospital management of patients with MI in eight Spanish population registries.Methods. The IBERICA study is a population-based MI registry carried out in the 25 to 74 year-old population, in eight Spanish regions in 1997. A standardized methodology was used to register and investigate all MI arriving alive to a hospital. Clinical characteristics, cardiovascular risk factors prevalence, pharmacological treatment, invasive and non-invasive procedures performed and complications at 28 days of evolution were recorded. A descriptive analysis was performed and the variation coefficient (VC) was calculated.Results. In 1997, 4,041 MI patients were registered, 79.9% were men with a mean age of 61.1 years. Although 10.9% (95% CI: 9.9-11.9%) were not admitted to the coronary care unit, a large variability existed among different areas (VC = 53%). There was a high variability in the utilization and performance of non-invasive and invasive procedures among regions, as well as in the use of pharmacological treatment. Only the use of antiaggregants (91.5%) and thrombolytic therapy (41.8%) showed a low variability (VC < 10%). Twenty-eight day mortality was 16.2% (95% CI: 15.1-17.4%) with a high variability being observed among the different regions (VC = 20.6%).Conclusion. Patient characteristics vary among the different Spanish regions. The differences in management and prognosis suggest a lack of equality in the health care provided to MI patients in the different regions in Spain.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA485196','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA485196"><span>Strategic Insights, Volume 5, Issue 2, February 2006. Uribe’s Second Mandate, the War, and the Implications for Civil-Military Relations in Colombia</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2006-02-01</p> <p>6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS( ES ) Naval Postgraduate...ADDRESS( ES ) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release...19. “Las FARC – Repliegue <span class="hlt">por</span> ‘ estrategia ’, o <span class="hlt">por</span> necesidad,” Centro de Analisis Socilpolitico, June 3, 2005; and “Situación de los terroristas</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA476980','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA476980"><span>Strengthening North American Security: A Strategy to Engage Mexico</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2005-04-01</p> <p>Secretaría de Comunicaciones y Transportes de México para ejercer más presión sobre SEDENA para que participe en NORAD. Incluso si SEDENA optara <span class="hlt">por</span> no...participar, NORAD aún puede perseguir la iniciativa de intercambio de información <span class="hlt">por</span> separado con la Secretaría de Comunicaciones y Transportes...Secretariat of Communication & Transportation Secretaría de Comunicaciones y Transportes Strategy Estrategia No loss of Mexican sovereignty No hay</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA220542','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA220542"><span>Relationship between Spain and the United States during the 18th and 19th Centuries</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>1990-03-21</p> <p>buiena correspandencis pars lo sucesivo; y si esta se difiriese a quando hubiese salida dle sus aprielas, ni sot voluntad estaria tan bien dispuesta, ni...ndidndase a voluntad . se podrdn internar hacia nuestres posesiones par [a espalda de Is Luisisna. H-ay que tcner presente quc el rio San Larenzo <span class="hlt">por</span> el...serd en su mano on poderoso ynstrumento. pars menearlo a so voluntad contra dichas naciones: y que Wse no quedara sin exercicia, <span class="hlt">por</span> mocha tiempo nadie</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29652114','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29652114"><span>Associations between vitamin D levels and polycystic ovary syndrome (PCOS) phenotypes.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Davis, Erin M; Peck, Jennifer D; Hansen, Karl R; Neas, Barbara R; Craig, LaTasha B</p> <p>2018-04-12</p> <p>Studies comparing serum 25-hydroxyvitamin D concentrations in women with and without PCOS have produced inconsistent results. Additionally, no previous studies have evaluated associations between vitamin D and specific PCOS phenotypes. This case-control study was conducted among women undergoing intrauterine insemination. Cases (n=137) were diagnosed with PCOS and then further classified into 3 diagnostic phenotypes based on combinations of the Rotterdam criteria [ovulatory dysfunction +polycystic ovaries (n=55); ovulatory dysfunction +androgen excess (n=15); and ovulatory dysfunction, +polycystic ovaries, +androgen excess (n=67)]. Controls (n=103) were ovulatory women without PCOS who were undergoing IUI. Serum total 25-hydroxyvitamin D concentrations were categorized as deficient (≤20 ng/ml), insufficient (21-29 ng/ml), and sufficient (≥30 ng/ml). Prevalence odds ratios (<span class="hlt">PORs</span>) were calculated using logistic regression. A higher proportion (59.9%) of PCOS cases lacked sufficient vitamin D levels compared to controls (47.6%; p-value=0.06). The odds of vitamin D deficiency in all PCOS cases were twice that of controls (<span class="hlt">POR</span>=2.03, 95% CI 0.97-4.26); however, the association was attenuated after adjusting for body mass index (BMI) and race/ethnicity (adj<span class="hlt">POR</span>=1.43,95% CI 0.62, 3.26). When examining PCOS phenotypes exhibiting androgen excess, crude associations were observed for deficient vitamin D levels (unadj<span class="hlt">POR</span>=2.93, 95% CI: 1.27, 6.77); however, the association decreased after adjustment for BMI and race/ethnicity (adj<span class="hlt">POR</span>=2.03, 95% CI: 0.79, 5.19). Vitamin D deficiency occurred more frequently in PCOS cases with androgen excess, but associations were attenuated after adjusting for BMI and race/ethnicity. Combining etiologically distinct PCOS subgroups may obscure associations with lower vitamin D levels and other potential risk factors.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20427135','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20427135"><span>Effect of endotoxin on the expression of GnRH and GnRHR genes in the hypothalamus and anterior pituitary gland of anestrous ewes.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Herman, Andrzej Przemysław; Tomaszewska-Zaremba, Dorota</p> <p>2010-07-01</p> <p>An immune/inflammatory challenge can affect reproduction at the level of the hypothalamus, pituitary gland, or gonads. Nonetheless, the major impact is thought to occur within the brain or the pituitary gland. The present study was designed to examine the effect of intravenous (i.v.) lipopolysaccharide (LPS) injection on the expression of gonadotropin-releasing hormone (GnRH) and the gonadotropin-releasing hormone receptor (GnRHR) genes in the hypothalamic structures where GnRH neurons are located as well as in the anterior pituitary gland (AP) of anestrous ewes. We also determined the effect of LPS on luteinizing hormone (LH) release. It was found that i.v. LPS injection significantly decreased GnRH and GnRHR mRNAs levels in the preoptic area (40%, <span class="hlt">p<or</span>=0.05 and 60%, <span class="hlt">p<or</span>=0.01 respectively) and median eminence (50% and 50% respectively; <span class="hlt">p<or</span>=0.01). Endotoxin injection decreased plasma LH concentration (25%; <span class="hlt">p<or</span>=0.05) and GnRHR gene expression (80%, <span class="hlt">p<or</span>=0.01) in the AP. Together, these observations indicate that inflammatory challenge can affect the reproductive system at the hypothalamic level through modulation of the activity of GnRH-ergic neurons as well as at the level of the AP via inhibition of LH secretion or/and through reduction of the sensitivity of GnRH reactive pituitary cells to GnRH stimulation. The presence of GnRH mRNA in the median eminence, the hypothalamic structure where GnRH-ergic neurons' terminals are located, suggests that the axonal transport of GnRH mRNA may occur in these neurons. This phenomenon could play an important role in the physiology of GnRH neurons. Our data demonstrate that immune stress could be important inhibitor of this process. Copyright 2010 Elsevier B.V. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4838395','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4838395"><span>TENDENCIA DE LA TUBERCULOSIS EN LA REGIÓN SANITARIA V DE LA PROVINCIA DE BUENOS AIRES, AÑOS 2000–2011</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>CHIRICO, CRISTINA; SANJURJO, MYRIAM; IRIBARREN, SARAH; APPENDINO, ANDREA; ZERBINI, ELSA; ETCHEVARRIA, MIRTA</p> <p>2016-01-01</p> <p>El objetivo del presente trabajo fue analizar la situación epidemiológica de la tuberculosis (TB) en la Región Sanitaria V (RSV), provincia de Buenos Aires. El estudio de tendencia permitió conocer un valor promedio de las variaciones de la tasa de incidencia (TI), calculadas <span class="hlt">por</span> regresión lineal simple y expresadas como variación anual promedio (VAP). Se analizaron el número de casos notificados y TI <span class="hlt">por</span> 100 000 habitantes de todas las formas de TB, los casos de TB pulmonar (TBP) y TBP confirmados <span class="hlt">por</span> bacteriología, total casos <span class="hlt">por</span> grupos de edad: 0 – 14; 15 – 29 y mayores de 64 años, entre el 1° de enero de 2000 al 31 de diciembre de 2011. La declinación de la TI fue menor al 5% para todas las formas de TB e inferior en las TBP confirmadas bacteriológicamente. Los casos de TBP y TI más elevadas, se concentraron en el grupo de 15 a 29 años, con tendencia estable o ligeramente ascendente de la TI en la TBP bacilífera. El mismo comportamiento presentaron los casos de TBP infantil con confirmación bacteriológica. La mayor velocidad de descenso en la TI de la TBP se produjo en este grupo de edad, mientras que en mayores de 64 años, el descenso fue sostenido en el tiempo. La TB persiste como un riesgo de salud en la RSV, con casos en edades jóvenes, <span class="hlt">por</span> lo que sigue siendo necesario fortalecer el control de la TB en esta región. PMID:26117604</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21190981','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21190981"><span>Pubertal presentation in seven patients with congenital adrenal hyperplasia due to P450 oxidoreductase deficiency.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Idkowiak, Jan; O'Riordan, Stephen; Reisch, Nicole; Malunowicz, Ewa M; Collins, Felicity; Kerstens, Michiel N; Köhler, Birgit; Graul-Neumann, Luitgard Margarete; Szarras-Czapnik, Maria; Dattani, Mehul; Silink, Martin; Shackleton, Cedric H L; Maiter, Dominique; Krone, Nils; Arlt, Wiebke</p> <p>2011-03-01</p> <p>P450 oxidoreductase (<span class="hlt">POR</span>) is a crucial electron donor to all microsomal P450 cytochrome (CYP) enzymes including 17α-hydroxylase (CYP17A1), 21-hydroxylase (CYP21A2) and P450 aromatase. Mutant <span class="hlt">POR</span> causes congenital adrenal hyperplasia with combined glucocorticoid and sex steroid deficiency. P450 oxidoreductase deficiency (ORD) commonly presents neonatally, with disordered sex development in both sexes, skeletal malformations, and glucocorticoid deficiency. The aim of the study was to describe the clinical and biochemical characteristics of ORD during puberty. Clinical, biochemical, and genetic assessment of seven ORD patients (five females, two males) presenting during puberty was conducted. Predominant findings in females were incomplete pubertal development (four of five) and large ovarian cysts (five of five) prone to spontaneous rupture, in some only resolving after combined treatment with estrogen/progestin, GnRH superagonists, and glucocorticoids. Pubertal development in the two boys was more mildly affected, with some spontaneous progression. Urinary steroid profiling revealed combined CYP17A1 and CYP21A2 deficiencies indicative of ORD in all patients; all but one failed to mount an appropriate cortisol response to ACTH stimulation indicative of adrenal insufficiency. Diagnosis of ORD was confirmed by direct sequencing, demonstrating disease-causing <span class="hlt">POR</span> mutations. Delayed and disordered puberty can be the first sign leading to a diagnosis of ORD. Appropriate testosterone production during puberty in affected boys but manifest primary hypogonadism in girls with ORD may indicate that testicular steroidogenesis is less dependent on <span class="hlt">POR</span> than adrenal and ovarian steroidogenesis. Ovarian cysts in pubertal girls may be driven not only by high gonadotropins but possibly also by impaired CYP51A1-mediated production of meiosis-activating sterols due to mutant <span class="hlt">POR</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=105946','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=105946"><span>Gonococcal Resistance to β-Lactams and Tetracycline Involves Mutation in Loop 3 of the Porin Encoded at the penB Locus</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Gill, M. J.; Simjee, S.; Al-Hattawi, K.; Robertson, B. D.; Easmon, C. S. F.; Ison, C. A.</p> <p>1998-01-01</p> <p>penB is a chromosomal mutation that confers resistance to β-lactams and tetracyclines and reduced susceptibility to quinolones in Neisseria gonorrhoeae. It is linked to the porin gene (<span class="hlt">por</span>) and requires the increased expression of an efflux pump due to mtr. Transformation of a susceptible gonococcus (strain H1) with chromosomal DNA from strain FA140 (penA mtr penB; porin serovar IB1) and conjugal transfer of a β-lactamase-expressing plasmid was used to produce isogenic strains for determination of equilibrium periplasmic penicillin concentrations by the method of Zimmermann and Rosselet (W. Zimmermann and A. Rosselet, Antimicrob. Agents Chemother. 12:368–372, 1977). In transformants with the Mtr and PenB phenotypes, equilibrium concentrations of penicillin were reduced. DNA sequence analysis of <span class="hlt">por</span> from isogenic penB and penB+ transformants revealed 14 sequence differences; nine of these differences resulted in amino acid changes. Three amino acid changes were found in the putative gonococcal equivalent of the pore-constricting loop 3 of Escherichia coli OmpF. Two of these changes (Gly-101–Ala-102→Asp-Asp) result in an increased negative charge at this position in <span class="hlt">por</span> loop 3. PCR products comprising the complete <span class="hlt">por</span> gene from strain FA140 were transformed into strain H1-2 (penA mtr; porin serovar IB-3), with the resulting transformants having the antibiotic susceptibility phenotype associated with penB. penB-like mutations were found in loop 3 of clinical isolates of gonococci with chromosomally mediated resistance to penicillin. We conclude that penB is a mutation in loop 3 of <span class="hlt">por</span> that reduces porin permeability to hydrophilic antibiotics and plays an important role in the development of chromosomally mediated resistance to penicillin and tetracycline in gonococci. PMID:9797206</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28733801','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28733801"><span>Effect of follicular flushing on reproductive outcomes in patients with poor ovarian response undergoing assisted reproductive technology.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Souza, Anna L M; Sampaio, Marcos; Noronha, Graciele B; Coster, Ludiana G R; de Oliveira, Roberta S G; Geber, Selmo</p> <p>2017-10-01</p> <p>The purpose of this study is to investigate the impact of follicular flushing on the number of oocytes retrieved, oocyte maturity, fertilization rate, embryo development, and pregnancy rate of poor ovarian responders (<span class="hlt">POR</span>). Retrospective study of 524 cycles of 384 patients with <span class="hlt">POR</span> submitted to assisted reproductive technology (ART) and who had follicular flushing during oocyte retrieval was used in the study. We included patients with <5 oocytes at oocyte retrieval (<span class="hlt">POR</span> group) and matching the Bologna criteria. <span class="hlt">POR</span> patients had a mean age of 38.2 ± 4.2 years. A total of 1355 follicles (mean = 3.5 ± 1.6) were aspirated and 1040 oocytes recovered, with 709 (68.2%) obtained by direct aspiration and 331 (31.8%) by follicular flushing. We found a difference between the total number of oocytes and the number of aspirated oocytes. Overall pregnancy rate was 22%. Association was observed between pregnancy rate and the number of oocytes retrieved, the number of MII oocytes, and the number of embryos transferred. The patients matching the Bologna criteria had a mean age of 38.9 ± 3.9 years. A total of 309 follicles were aspirated (mean = 3.1 ± 1.5) and 242 oocytes recovered, with 156 (64.5%) obtained by direct aspiration and 86 (35.5%) by follicular flushing. There was a significant difference between the total number of oocytes and the number of aspirated oocytes. Overall pregnancy rate was 12.1%. There was no association between the pregnancy rate and the number of oocytes retrieved, the number of MII, and the number of embryos. Follicular flushing might be a suitable alternative to increase the number of oocytes and pregnancy rates in patients with <span class="hlt">POR</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=123224','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=123224"><span>Enzymology below 200 K: The kinetics and thermodynamics of the photochemistry catalyzed by protochlorophyllide oxidoreductase</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Heyes, Derren J.; Ruban, Alexander V.; Wilks, Helen M.; Hunter, C. Neil</p> <p>2002-01-01</p> <p>The chlorophyll biosynthesis enzyme protochlorophyllide reductase (<span class="hlt">POR</span>) catalyzes the light-dependent reduction of protochlorophyllide (Pchlide) into chlorophyllide in the presence of NADPH. As <span class="hlt">POR</span> is light-dependent, catalysis can be initiated by illumination of the enzyme-substrate complex at low temperatures, making it an attractive model for studying aspects of biological proton and hydride transfers. The early stages in the photoreduction, involving Pchlide binding and an initial photochemical reaction, have been studied in vitro by using low-temperature fluorescence and absorbance measurements. Formation of the ternary <span class="hlt">POR</span>-NADPH-Pchlide complex produces red shifts in the fluorescence and absorbance maxima of Pchlide, allowing the dissociation constant for Pchlide binding to be measured. We demonstrate that the product of an initial photochemical reaction, which can occur below 200 K, is a nonfluorescent intermediate with a broad absorbance band at 696 nm (A696) that is suggested to represent an ion radical complex. The temperature dependence of the rate of A696 formation has allowed the activation energy for the photochemical step to be calculated and has shown that <span class="hlt">POR</span> catalysis can proceed at much lower temperatures than previously thought. Calculations of differences in free energy between various reaction intermediates have been calculated; these, together with the quantum efficiency for Pchlide conversion, suggest a quantitative model for the thermodynamics of the light-driven step of Pchlide reduction. PMID:12177453</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28373551','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28373551"><span>Identification of specific posttranslational O-mycoloylations mediating protein targeting to the mycomembrane.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Carel, Clément; Marcoux, Julien; Réat, Valérie; Parra, Julien; Latgé, Guillaume; Laval, Françoise; Demange, Pascal; Burlet-Schiltz, Odile; Milon, Alain; Daffé, Mamadou; Tropis, Maryelle G; Renault, Marie A M</p> <p>2017-04-18</p> <p>The outer membranes (OMs) of members of the Corynebacteriales bacterial order, also called mycomembranes, harbor mycolic acids and unusual outer membrane proteins (OMPs), including those with α-helical structure. The signals that allow precursors of such proteins to be targeted to the mycomembrane remain uncharacterized. We report here the molecular features responsible for OMP targeting to the mycomembrane of Corynebacterium glutamicum , a nonpathogenic member of the Corynebacteriales order. To better understand the mechanisms by which OMP precursors were sorted in C. glutamicum , we first investigated the partitioning of endogenous and recombinant <span class="hlt">Por</span>A, <span class="hlt">Por</span>H, <span class="hlt">Por</span>B, and <span class="hlt">Por</span>C between bacterial compartments and showed that they were both imported into the mycomembrane and secreted into the extracellular medium. A detailed investigation of cell extracts and purified proteins by top-down MS, NMR spectroscopy, and site-directed mutagenesis revealed specific and well-conserved posttranslational modifications (PTMs), including O -mycoloylation, pyroglutamylation, and N -formylation, for mycomembrane-associated and -secreted OMPs. PTM site sequence analysis from C. glutamicum OMP and other O -acylated proteins in bacteria and eukaryotes revealed specific patterns. Furthermore, we found that such modifications were essential for targeting to the mycomembrane and sufficient for OMP assembly into mycolic acid-containing lipid bilayers. Collectively, it seems that these PTMs have evolved in the Corynebacteriales order and beyond to guide membrane proteins toward a specific cell compartment.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5402430','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5402430"><span>Identification of specific posttranslational O-mycoloylations mediating protein targeting to the mycomembrane</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Carel, Clément; Réat, Valérie; Parra, Julien; Latgé, Guillaume; Laval, Françoise; Burlet-Schiltz, Odile; Milon, Alain; Daffé, Mamadou; Tropis, Maryelle G.; Renault, Marie A. M.</p> <p>2017-01-01</p> <p>The outer membranes (OMs) of members of the Corynebacteriales bacterial order, also called mycomembranes, harbor mycolic acids and unusual outer membrane proteins (OMPs), including those with α-helical structure. The signals that allow precursors of such proteins to be targeted to the mycomembrane remain uncharacterized. We report here the molecular features responsible for OMP targeting to the mycomembrane of Corynebacterium glutamicum, a nonpathogenic member of the Corynebacteriales order. To better understand the mechanisms by which OMP precursors were sorted in C. glutamicum, we first investigated the partitioning of endogenous and recombinant <span class="hlt">Por</span>A, <span class="hlt">Por</span>H, <span class="hlt">Por</span>B, and <span class="hlt">Por</span>C between bacterial compartments and showed that they were both imported into the mycomembrane and secreted into the extracellular medium. A detailed investigation of cell extracts and purified proteins by top-down MS, NMR spectroscopy, and site-directed mutagenesis revealed specific and well-conserved posttranslational modifications (PTMs), including O-mycoloylation, pyroglutamylation, and N-formylation, for mycomembrane-associated and -secreted OMPs. PTM site sequence analysis from C. glutamicum OMP and other O-acylated proteins in bacteria and eukaryotes revealed specific patterns. Furthermore, we found that such modifications were essential for targeting to the mycomembrane and sufficient for OMP assembly into mycolic acid-containing lipid bilayers. Collectively, it seems that these PTMs have evolved in the Corynebacteriales order and beyond to guide membrane proteins toward a specific cell compartment. PMID:28373551</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26116854','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26116854"><span>The effects of telemedicine on racial and ethnic disparities in access to acute stroke care.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lyerly, Michael J; Wu, Tzu-Ching; Mullen, Michael T; Albright, Karen C; Wolff, Catherine; Boehme, Amelia K; Branas, Charles C; Grotta, James C; Savitz, Sean I; Carr, Brendan G</p> <p>2016-03-01</p> <p>Racial and ethnic disparities have been previously reported in acute stroke care. We sought to determine the effect of telemedicine (TM) on access to acute stroke care for racial and ethnic minorities in the state of Texas. Data were collected from the US Census Bureau, The Joint Commission and the American Hospital Association. Access for racial and ethnic minorities was determined by summing the population that could reach a primary stroke centre (PSC) or telemedicine spoke within specified time intervals using validated models. TM extended access to stroke expertise by 1.5 million residents. The odds of providing 60-minute access via TM were similar in Blacks and Whites (prevalence odds ratios (<span class="hlt">POR</span>) 1.000, 95% CI 1.000-1.000), even after adjustment for urbanization (<span class="hlt">POR</span> 1.000, 95% CI 1.000-1.001). The odds of providing access via TM were also similar for Hispanics and non-Hispanics (<span class="hlt">POR</span> 1.000, 95% CI 1.000-1.000), even after adjustment for urbanization (<span class="hlt">POR</span> 1.000, 95% CI 1.000-1.000). We found that telemedicine increased access to acute stroke care for 1.5 million Texans. While racial and ethnic disparities exist in other components of stroke care, we did not find evidence of disparities in access to the acute stroke expertise afforded by telemedicine. © The Author(s) 2015.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2004PhDT.......159G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2004PhDT.......159G"><span>Modos de produccion cientifica: Culturas y metodologias de investigacion en la Universidad de Cadiz</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gonzalez Ramos, Ana M.</p> <p>2004-12-01</p> <p>Este trabajo de investigacion supone un modelo teorico de caracter aplicado, que proporciona la oportunidad de evaluar la produccion cientifica de los investigadores. Se encuadra dentro de la tradiccion de la estadistica aplicada y la sociologia del conocimiento. Atiende especialmente a dos conjuntos de temas de interes, <span class="hlt">por</span> una parte, las caracteristicas principales que determinan el nivel y tipo de produccion academica producida <span class="hlt">por</span> las unidades de investigacion y <span class="hlt">por</span> los propios investigadores; <span class="hlt">por</span> otra, la utilizacion que se hace de los metodos y tecnicas de investigacion puesto que de ello tambien depende el modo de produccion cientifica. Los puntos novedosos de esta tesis son: la medicion cuantitativa del objeto de estudio, la suma de los productos y las condiciones externas a la produccion del conocimiento mas otros elementos internos como las caracteristicas de los investigadores y la metodologia utilizada para desarrollar sus trabajos; y, finalmente, el uso de las nuevas tecnologias. El aprovechamiento de los recursos estadisticos y las fuentes de informacion secundarias se complementan con el diseno propio de una encuesta donde se implementa las caracteristicas descritas en un capitulo anterior sobre los metodos cientificos mas idoneos descritos en los principales manuales y articulos cientificos desde distintas disciplinas de conocimiento. Dicha encuesta ha sido desarrollada como un programa propio y en base a los mas innovadores usos de la tecnologia en la metodologia de encuestas.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA497235','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA497235"><span>Assessing the Potential for Interstate Conflict Between Chile and Peru: A Political Economy Approach</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2009-03-01</p> <p>Militares Peru-Chile no Se Han Afectado <span class="hlt">por</span> Diferendo,” El Comercio , April 6, 2008. 329 Chile/Peru: Tensions Flare on Maritime Border Change.” 330 “FF...Relaciones Militares Peru-Chile no Se Han Afectado <span class="hlt">por</span> Diferendo.” El Comercio , April 6, 2008. “Relations Falter for Peru, Chile.” Chicago Tribune...América Latina y el Mediterráneo (Centro de Estudios e Investigaciones Militares: Santiago, 2000), 82. 129 “A. P. Bureau Chief in Peru is Ordered out of</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_25 --> <div class="footer-extlink text-muted" style="margin-bottom:1rem; text-align:center;">Some links on this page may take you to non-federal websites. 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