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Sample records for aina leeben ilmar

  1. Malama I Ka `Aina: Fostering the Culture-Science connection

    NASA Astrophysics Data System (ADS)

    Bruno, B.; Chinn, P.

    2005-12-01

    The Malama I Ka `Aina Project (Caring for the land, or sustainability) aims to improve and expand the education of Hawai`i's children by developing and disseminating standards-based, culturally relevant science curricular materials based on an understanding and appreciation of the ways in which traditional Hawaiians interacted with their environment for sustainability. Key concepts include the role of water and the ahupua`a (traditional Hawaiian system of land management), and a culture-based sense of place that includes knowledge of and connection to the land. Elementary, middle, high school and University of Hawai`i teachers work together to develop and implement curricula that are especially relevant to a particular school's science program and issues, e.g., invasive species, students, community and/or geographical location. Participants (typically a mix of teachers, education majors and science majors) enroll in Malama I Ka `Aina, a three-credit course offered through the University of Hawai`i`s Dept. of Curriculum Studies and applicable toward a Bachelor's or Master's degree. This course (team taught by scientists, cultural experts and educational professionals) enables participants to: (1) Study Hawai`i`s unique geology, geography and environmental issues in the context of Hawaiian culture and post Western contact; (2) Use course knowledge to develop, teach and assess Hawaii-oriented, project-based, inquiry activities that address the Hawaii Science Content Standards; (3) Gain an appreciation for the scientific method, and the curiosity that drives science (4) Use educational technology such as PowerPoint, graphing packages and web authoring software to develop electronic resources for educational activities. A sample of the lessons developed by course participants can be found on http://malama.hawaii.edu/schools/index2.html. This project is based at the University of Hawai`i College of Education and funded by an award to P. Chinn by the US Department of

  2. Aloha Aina: Native Hawaiians Fight for Survival

    ERIC Educational Resources Information Center

    Kealoha, Gard

    1976-01-01

    Discusses the history, values, and cultural background of the native Hawaiian population, asserting that Hawaiians want to recapture and reaffirm the native rights guaranteed by the constitution of Hawaii in 1846. (Author/JM)

  3. "He Pu'a Kani 'Aina": Mapping Student Growth in Hawaiian-Focused Charter Schools

    ERIC Educational Resources Information Center

    Kana'iaupuni, Shawn Malia

    2008-01-01

    Fourteen of the startup charter schools in the State of Hawai'i are Hawaiian-focused, providing an education grounded in culturally relevant content and context. This study centers on outcomes in these Hawaiian-focused charter schools, which have demonstrated their value to the community, serving the educational needs of an increasing number of…

  4. "Malama I Ka 'Aina, Sustainability": Learning from Hawai'i's Displaced Place and Culture-Based Science Standard

    ERIC Educational Resources Information Center

    Chinn, Pauline W. U.

    2011-01-01

    This response to Mitchell and Mueller's "A philosophical analysis of David Orr's theory of ecological literacy" comments on their critique of Orr's use of the phrase "ecological crisis" and what I perceive as their conflicting views of "crisis." I present my views on ecological crisis informed by standpoint theory and the definition of crisis as…

  5. Cherry Picking in the ‘Aina: Inequalities of Access to Dermatologic Care in Hawai‘i

    PubMed Central

    Ferrara, Mariah L; Johnson, Douglas W

    2015-01-01

    There is evidence that people who are insured by Medicaid have difficulty accessing health care from private providers. This study documents access to dermatology care for a hypothetical patient insured by Medicaid in the State of Hawai‘i. Posing as young Medicaid patient with a changing mole, we called all dermatologists listed on the American Academy of Dermatology website and requested an appointment to be seen. Only 23% of dermatologists contacted accept all Medicaid plans and an additional 12% accept some. Thus 65% of dermatologists called do not provide specialist care to Hawai‘i's Medicaid population. PMID:26114073

  6. American Indians/Native Alaskans with Traumatic Brain Injury: Examining the Impairments of Traumatic Brain Injury, Disparities in Service Provision, and Employment Outcomes

    ERIC Educational Resources Information Center

    Whitfield, Harold Wayne; Lloyd, Rosalind

    2008-01-01

    The researchers analyzed data from fiscal year 2006 and found that American Indians/Native Alaskans (AI/NA) with traumatic brain injury experienced similar functional limitations at application as did non-AI/NA. Fewer funds were expended on purchased services for AI/NA than for non-AI/NA. The wages of AI/NA were equitable to those of non-AI/NA at…

  7. Alcohol Screening and Brief Intervention as Standard Practice: Working with the American Indian/Native Alaskan Populations

    PubMed Central

    Patterson Silver Wolf (Adelv unegv Waya), David A.; Duran, Bonnie; Dulmus, Catherine N.; Manning, Amy R.

    2014-01-01

    Alcohol use and the resulting problems associated with high-risk drinking in the American Indian/Native Alaskan (AI/NA) population are well-documented, as alcohol misuse has taken an incredible toll on many AI/NA communities. Presently, both overall health issues and alcohol use occur disproportionately within this population. This article provides an updated overview of the impact of alcohol use in the United States and within AI/NA communities specifically. It also provides recommendations for an alcohol-related screening and brief intervention instrument that social workers can begin using in their practice and can be utilized within the AI/NA community. PMID:25580074

  8. American Indian Studies as an Academic Discipline

    ERIC Educational Resources Information Center

    Kidwell, Clara Sue

    2011-01-01

    When American Indian/Native American studies (AI/NAS) programs began to emerge in the halls of academia during the late 1960s and early 1970s, some who served as faculty and staff questioned whether they would be one-generation phenomena. Would the programs survive, would they continue to draw students, and could they make an impact on…

  9. Effect of prolonged depolarizations on twitch tension and intracellular sodium activity in sheep cardiac Purkinje fibres.

    PubMed Central

    Brill, D M; Fozzard, H A; Makielski, J C; Wasserstrom, J A

    1987-01-01

    1. Twitch tension and intracellular Na+ activity (aiNa) were measured in voltage-clamped sheep cardiac Purkinje fibres. aiNa was measured using Na+-sensitive micro-electrodes filled with the liquid ion exchange resin. ETH 227. The stimulus for contraction was a constant 200 ms depolarizing pulse to 0 mV from a holding potential of -80 mV delivered at 0.25 Hz. Prolonged test pulses for 1.8 s (post-pulses) were applied at the end of the stimulus pulse. The effects of post-pulses on twitch tension and aiNa were examined. 2. Post-pulses in the range of -40 mV reduced twitch tension below control force produced without post-pulse. Progressively more positive post-pulses to levels above 0 mV profoundly increased twitch tension, with a greater than 400% rise in tension at +50 to +60 mV compared to control tension. aiNa declined at positive post-pulse potentials by more than 2 mM at +30 to +40 mV. 3. Tetrodotoxin (100 microM) did not affect the post-pulse voltage-tension or voltage-aiNa relation. Ca2+ channel modulation with nitrendipine (1 microM) similarly did not alter the post-pulse voltage-tension relation. 4. Removal of extracellular Na+ eliminated the nadir in tension at post-pulses to -40 mV and the augmentation of tension at post-pulses above 0 mV. 5. We interpret these findings as evidence of voltage-sensitive Na-Ca exchange promoting net Ca2+ influx and net Na+ efflux during positive post-pulses. The unusual shape of the post-pulse voltage-tension relation curve can be accounted for by a charged-carrier model of electrogenic Na-Ca exchange. The inverse relation between aiNa and twitch tension probably reflects the combined effects of reduced aiNa leak and changes in Na+ and Ca2+ flux via voltage-sensitive Na-Ca exchange. PMID:2443661

  10. Ionic mechanism of a quasi-stable depolarization in barnacle photoreceptor following red light.

    PubMed

    Brown, H M; Cornwall, M C

    1975-07-01

    1. The membrane mechanism of a quasi-stable membrane depolarization (latch-up) that persists in darkness following red light was examined in barnacle photoreceptor with micro-electrode techniques including voltage-clamp and Na+-sensitive micro-electrodes. 2. Current-voltage (I-V) relations of the membrane in darkness following red light (latch-up) and in darkness following termination of latch-up with green light, indicate that latch-up is associated with an increase of membrane conductance. 3. The latch-current (membrane current in darkness following red light minus membrane current in darkness following a gree flash that terminates latch-up) was inward at the resting potential, reversed sign at about +26mV (mean of six cells), and became outward at more positive membrance potentials. 4. Current-voltage relations of the membrane during green light (no latch-up) closely resembled those during latch-up. The light-induced current (LIC) elicited by green ligh (membrane current during the light flash minus membrane current in darkness following the light flash) was inward from the resting potential to +26mV (mean of six cells), then reversed sign and became outward. 5. The latch-current and LIC were both augmented in reduced Ca2+ solutions and decreased as Na-+ was reduced at a fixed Ca2+ concentration. 6. Both LIC and latch-current reversed sign at a more negative membrane potential (increment V equals 14mV) in solutions containing one quarter the normal amount of Na+. 7. The internal Na-+ activity (a-iNa) of a photoreceptor increased from about 10-18 mM upon illumination with long steps of intense red or white illumination. Five minutes in darkness after white light, a-iNa had recovered significantly, whereas a-iNa remained elecated following red illumination. 8. Latch-up seems to be a persistence in darkness of the same membrane mechanism that normally occurs during illumination; i.e. a conductance increase to Na+ ions. Ca2+ ions act primarily to suppress this

  11. [The Siberian and Far-Eastern subtypes of tick-borne encephalitis virus registered in Russia's Asian regions: genetic and antigen characteristics of the strains].

    PubMed

    Pogodina, V V; Bochkova, N G; Karan', L S; Trukhina, A G; Levina, L S; Malenko, G V; Druzhinina, T A; Lukashenko, Z S; Dul'keĭt, O F; Platonov, A E

    2004-01-01

    Agar gel precipitation test with cross-adsorbed immune sera was used for the antigenic differentiation of strains of tick-borne encephalitis virus (TBEV). Fifty strains of the Far East TBEV serotype and 46 strains of the Siberian (Aina) TBEV serotype were isolated from Ixodes persulcatus, which is the main vector of the above TBEV subtypes in the Asian and European parts of Russia. The fragment of the envelope protein gene was sequenced for TBEV strains. Sequences of new-group strains of the Siberian subtypes isolated from 3 patients with chronic TBE and from brain tissues of 4 deceased patients were determined. Lethal TBE outcomes were registered in Siberia (Irkutsk Region and Krasnoyarsk Territory) and in Russia's European part (Yaroslavl Region). PMID:15293507

  12. Influence of cobalt uptake by Vicia faba seeds on chlorophyll morphosis induction, SOD polymorphism, and DNA methylation.

    PubMed

    Rancelis, Vytautas; Cesniene, Tatjana; Kleizaite, Violeta; Zvingila, Donatas; Balciuniene, Laimute

    2012-01-01

    Vicia faba plants show polymorphism to cobalt (Co) excess, expressed by a different degree of chlorophyll morphosis (CM)-from normally green (N) to yellow (Y) seedlings. For superoxide dismutase (SOD), the high V. faba polymorphism was revealed and increased by Co stress. Epigenetic mechanisms may be involved in both phenomena. For such reasons, we investigated the effect of 5-azacytosine (AzaC) and Na butyrate (NaBut) on CM induction, SOD polymorphism, and DNA methylation-demethylation events in Co(NO(3) )(2) affected plants, without or with AzaC or NaBut. CMs were induced after treatment of seeds for 8 h with 7.5 mM Co(NO(3) )(2) plus 12 h with H(2) O or 8 h with H(2) O plus 12 h with Co(NO(3) )(2) . In the same order AzaC and NaBut were applied in concentrations equimolar to Co(NO(3) )(2) . SOD isoforms were investigated electrophoretically, and for DNA methylation-demethylation events the Aina [Aina et al. (2004) Physiol Plant 121:472-480] system was applied upon using the random amplified polymorphic DNA (RAPD) method employing restrictases MspI and HpaII. The effect of AzaC and NaBut on CM induction in combination with Co was unclear. Posttreatment with Co was more effective than Co-pretreatment. SOD polymorphism was significantly strengthened by NaBut. Detection of DNA methylation-demethylation events depended on the primers used for RAPD analysis. With AP5 and MP4 primers, DNA demethylation was observed in N-seedlings after exposure to Co, AzaC or NaBut applied separately. With primer A6, only DNA methylation events were determined in N-seedlings from seeds exposed to Co or Co-AzaC, and in Y-seedlings after Co-AzaC or Co-NaBut treatment. UPGMA grouping of the results showed that all N-seedlings comprised one common cluster after Co exposure, independently of treatment combinations (Co alone, Co with AzaC, Co with NaBut). On the contrary, no significant differences were determined in SOD polymorphism among the most resistant N-seedlings and the most severely

  13. Problems in Assessment of Wind Energy Potential and Acoustic Noise Distribution when Designing Wind Power Plants

    NASA Astrophysics Data System (ADS)

    Bezrukovs, Valerijs; Bezrukovs, Vladislavs; Levins, Nikolajs

    2011-01-01

    Interest in the use of renewable energy in Latvia is increasing every year. Government support and availability of large unpopulated areas on the coast makes the use of these lands for the placement of large wind power plants (WPP) attractive. The key factors that determine the choice of the location of WPP are reliable information about distribution of the resource of wind energy in this area and the influence of wind turbines on the environment. The paper presents the results of years-long observations on the density fluctuations of wind energy at heights of 10 to 60 m in the area in the Baltic Sea coast in Ventspils and Ainaži. The velocity observations since 2007 have been gathered by measurements complex of the LOGGER 9200 Symphonie type. The results are presented in the form of tables, bar charts and graphs. Extrapolation results of wind velocity and density mean values on heights up to 150 m for the two areas with different terrain types were shown. The distribution of acoustic noise in the vicinity of the WPP was studied and an assessment of its impact on the environment in accordance with the Latvian government requirements was conducted.

  14. Changes of contractile responses due to simulated weightlessness in rat soleus muscle

    NASA Astrophysics Data System (ADS)

    Elkhammari, A.; Noireaud, J.; Léoty, C.

    1994-08-01

    Some contractile and electrophysiological properties of muscle fibers isolated from the slow-twitch soleus (SOL) and fast-twitch extensor digitorum longus (EDL) muscles of rats were compared with those measured in SOL muscles from suspended rats. In suspendede SOL (21 days of tail-suspension) membrane potential (Em), intracellular sodium activity (aiNa) and the slope of the relationship between Em and log [K]o were typical of fast-twitch muscles. The relation between the maximal amplitude of K-contractures vs Em was steeper for control SOL than for EDL and suspended SOL muscles. After suspension, in SOL muscles the contractile threshold and the inactivation curves for K-contractures were shifted to more positive Em. Repriming of K-contractures was unaffected by suspencion. The exposure of isolated fibers to perchlorate (ClO4-)-containing (6-40 mM) solutions resulted ina similar concentration-dependent shift to more negative Em of activation curves for EDL and suspended SOL muscles. On exposure to a Na-free TEA solution, SOL from control and suspended rats, in contrast to EDL muscles, generated slow contractile responses. Suspended SOL showed a reduced sensitivity to the contracture-producing effect of caffeine compared to control muscles. These results suggested that the modification observed due to suspension could be encounted by changes in the characteristics of muscle fibers from slow to fast-twitch type.

  15. [Characteristics of tick-borne encephalitis virus strains isolated from patients with chronic diseases of the central nervous system].

    PubMed

    Pogodina, V V; Meĭerova, R A; Bochkova, N G; Koreshkova, G V

    1985-01-01

    Two groups of tick-borne encephalitis (TBE) virus strains were studied: Group 1, 5 strains isolated from patients with chronic TBE with progressive course, Group 2, 13 strains isolated from residents of an endemic locality, with chronic diseases of the CNS (amiotrophic lateral sclerosis, epidemic encephalitis, polyoencephalomyelitis, syringomyelia, etc.). Strains of both groups belong to two serotypes of TBE virus: mid-Siberian and Transbaikal (synonym Aina/1448) and eastern. Group 1 strains were heterogeneous in their virulence, immunogenic and surface properties of the virions. The latter characteristic was demonstrated in studies of elution from macropore glass and sensitivity of hemagglutinin to the effect of detergents (Bridge-96, Tween-80). Eight of 13 Group 2 patients had concurrent diseases (tuberculosis, toxoplasmosis, tumors, etc.). Streptomycin was demonstrated to activate asymptomatic infection with TBE virus in hamsters. It is assumed that isolation of TBE virus from Group 2 patients could be due to activation of persistent infection under the effect of concurrent diseases and drugs. PMID:4060699

  16. Ka mauli o ka 'oina a he mauli kanaka: an ethnographic study from an Hawaiian sense of place.

    PubMed

    Oneha, M F

    2001-09-01

    Ka Mauli O Ka 'Aina A He Mauli Kanaka: The Life of the Land is the Life of the People. A sense of place has been directly linked to spiritual well being for all indigenous peoples. Yet, there is minimal evidence that demonstrates understanding and awareness of indigenous health issues from this perspective. Health, or the lack of it, appears to be related to place or the loss of it. Issues of Hawaiian health are inseparable from issues of land, water, and atmosphere. The purpose of this research study was to explore the experience of a sense of place and its relationship to health as perceived and experienced by Hawaiian participants living in Wai'anae, Hawai'i. Thirteen adult men and women, ranging in age from 36 to 80 years, participated in this ethnographic study. Two interviews conducted with each participant addressed the research question, "What is the experience of the relationship between a sense of place and health for Hawaiians?" Participants were also asked to photograph how they experienced this relationship. The qualitative data analysis computer software, Atlas.ti, was used to assist in data analysis. The findings suggest that the relationship between sense of place and health embodies four categories: (1) relationship to akua (god, spirit), (2) relationship to natural elements, (3) relationship to self and others, and (4) belonging to a particular place. Three major traditional Hawaiian concepts, which defined how the relationship between sense of place and health are experienced, were pono, mana, and kuleana. The relationship between these concepts revealed five cultural themes. Health for Hawaiians: I. is having a spiritual connection to their ancestral place; II. relates to the past, present, and future; III. is experienced with intention and understanding; IV. means an openness to the flow and use of energy; and V. is experienced as a pu'uhonua or safe place. These themes suggest implications for Hawaiian health education, practice, and further

  17. Science in Hawaii/Haawina Hoopapau: A Culturally Responsive Curriculum Project

    NASA Astrophysics Data System (ADS)

    Galloway, L. M.; Roberts, K.; Leake, D. W.; Stodden, R. S.; Crabbe, V.

    2005-12-01

    The marvels of modern science often fail to engage indigenous students, as the content and instructional style are usually rooted in the Western experience. This 3 year project, funded by the US Dept. of Education for the Education of Native Hawaiians, offers a curriculum that teaches science through (rather than just about) Native Hawaiian culture. The curriculum focuses on the interdependence of natural resources in our ahupuaa, or watersheds, and helps students strengthen their sense of place and self to malama i ka aina, to care for the land. Further, the curriculum is designed to: engage students in scientific study with relevant, interesting content and activities; improve student achievement of state department of education standards; increase student knowledge and skills in science, math and language arts; respond to the learning needs of Native Hawaiian and/or at-risk students. The project will be presented by a curriculum writer who created and adapted more than a year's worth of materials by teaming with kupuna (respected elders), local cultural experts and role models, educators (new, veteran, Hawaiian, non-Hawaiian, mainland, general and special education teachers), and professionals at the Center on Disability Studies at the University of Hawaii and ALU LIKE, Inc, a non-profit organization to assist Native Hawaiians. The materials created thus far are available for viewing at: www.scihi.hawaii.edu The curriculum, designed for grades 8-11 science classes, can be used to teach a year-long course, a unit, or single lesson related to astronomy, biology, botany, chemistry, geology, oceanography, physical and environmental sciences. This project is in its final year of field testing, polishing and dissemination, and therefore this session will encourage idea sharing, as does our copyright free Web site.

  18. Teaching change to local youth: Plant phenology, climate change and citizen science at Hakalau Forest National Wildlife Refuge

    NASA Astrophysics Data System (ADS)

    Litton, C. M.; Laursen, S. C.; Phifer, C.; Giardina, C. P.

    2012-12-01

    Plant phenology is a powerful indicator of how climate change affects native ecosystems, and also provides an experiential outdoor learning opportunity for promoting youth conservation education and awareness. We developed a youth conservation education curriculum, including both classroom and field components, for local middle and high school students from Hawaii. The curriculum is focused on linking plant phenology and climate change, with emphasis on ecologically and culturally important native trees and birds at Hakalau Forest National Wildlife Refuge (NWR), on the Island of Hawaii. In this curriculum, students: (i) visit Hakalau Forest NWR to learn about the ecology of native ecosystems, including natural disturbance regimes and the general concept of change in forest ecosystems; (ii) learn about human-induced climate change and its potential impact on native species; and (iii) collect plant phenology measurements and publish these data on the USA National Phenology Network website. This youth conservation education curriculum represents a close collaboration between Hakalau Forest NWR; the Friends of Hakalau Forest NWR; the College of Tropical Agriculture and Human Resources at the University of Hawaii at Manoa; the USDA Forest Service; and Imi Pono no Ka Aina, an environmental education and outreach program for the Three Mountain Alliance Watershed Partnership. In the Winter and Spring of 2011-2012, we developed classroom and field portions of the curriculum. In the Spring and Summer of 2012, we recruited four groups of participants, with a total of ~40 students, who visited the refuge to participate in the curriculum. Preliminary phenology observations based upon ~4 months of measurements show low to medium levels of flowering, fruiting and leaf flush. However, the real science value of this program will come over years to decades of accumulated student activity. From this, we anticipate the emergence of a unique tropical montane forest dataset on plant

  19. PREFACE: Annual Conference on Functional Materials and Nanotechnologies - FM&NT 2011

    NASA Astrophysics Data System (ADS)

    Sternberg, Andris; Muzikante, Inta; Zicans, Janis

    2011-06-01

    Conference photograph ERAF logo International Organizing Committee Andris Sternberg (chairperson), Institute of Solid State Physics, University of Latvia, Latvia, MATERA Juras Banys, Vilnius University, Lithuania Gunnar Borstel, University of Osnabrück, Germany Niels E Christensen, University of Aarhus, Denmark Robert A Evarestov, St. Petersburg State University, Russia Claes-Goran Granqvist, Uppsala University, Sweden Dag Høvik, The Research Council of Norway, Norway, MATERA Marco Kirm, Institute of Physics, University of Tartu, Estonia Vladislav Lemanov, Ioffe Physical Technical Institute, Russia Witold Lojkowski, Institute of High Pressure Physics, Poland Ergo Nommiste, University of Tartu, Estonia Helmut Schober, Institut Laue-Langevin, France Sisko Sipilä, Finnish Funding Agency for Technology and Innovation, Finland, MATERA Ingólfur Torbjörnsson, Icelandic Centre for Research, Iceland, MATERA Marcel H Van de Voorde, University of Technology Delft, The Netherlands International Program Committee Inta Muzikante (chairperson), Institute of Solid State Physics, University of Latvia, Latvia, MATERA Liga Berzina-Cimdina, Institute of Biomaterials and Biomechanics, Riga Technical University, Latvia Janis Grabis, Institute of Inorganic Chemistry, Riga Technical University, Latvia Leonid V Maksimov, Vavilov State Optical Institute, Russia Linards Skuja, Institute of Solid State Physics, University of Latvia, Latvia Maris Springis, Institute of Solid State Physics, University of Latvia, Latvia Ilmars Zalite, Institute of Inorganic Chemistry, Riga Technical University, Latvia Janis Zicans, Institute of Polymers, Riga Technical University Local Committee: Liga Grinberga, Anatolijs Sarakovskis, Jurgis Grube, Raitis Siatkovskis, Maris Kundzins, Anna Muratova, Maris Springis, Aivars Vembris, Krisjanis Smits, Andris Fedotovs, Dmitrijs Bocarovs, Anastasija Jozepa, Andris Krumins.

  20. Intracellular sodium activity and its regulation in guinea-pig atrial myocardium.

    PubMed Central

    Wang, G X; Schmied, R; Ebner, F; Korth, M

    1993-01-01

    1. Intracellular Na+ activity (aNai) and membrane resting potential were studied in quiescent guinea-pig atrial and papillary muscles by means of Na(+)-sensitive and conventional microelectrodes. The effects of the cardioactive steroid dihydroouabain (DHO) on aiNa, force of contraction and sarcolemmal Na+, K(+)-ATPase activity were also investigated. 2. In thirty atria and twenty-two papillary muscles, aNai amounted to 8.0 +/- 0.2 and 4.7 +/- 0.3 mM, respectively (mean +/- S.E.M.). When both tissues were from the same animal, with the same ion-sensitive microelectrode mean aNai values of 7.9 +/- 0.2 and 5.1 +/- 0.5 mM (P < 0.01) were obtained from eight atrial and eight papillary muscles, respectively. 3. Membrane resting potentials (Em) were significantly (P < 0.001) more negative in the papillary muscles (-83.5 +/- 0.7 mV; n = 8) than in the atrium (-78.1 +/- 0.5 mV; n = 8). Deviation of Em from EK (determined by K(+)-sensitive microelectrodes) was 3.0 +/- 0.2 mV in ventricular (P < 0.05) and 6.1 +/- 0.3 mV in atrial preparations (P < 0.05). 4. Inhibition of the Na+ pump by DHO increased aNai of the atrium within 10 min by 0.6 +/- 0.1 (n = 7), 1.3 +/- 0.1 (n = 5) and 3.2 +/- 0.2 mM (n = 5) at 5, 10 and 30 microM, respectively. In the papillary muscle, 10 microM DHO was without effect while aNai rose by 1.0 +/- 0.1 (n = 5) and 2.9 +/- 0.2 mM (n = 6) at 30 and 120 microM DHO. 5. Consistent with the aNai measurements, the potency of DHO to increase force of the isometric contraction was three times higher in atrium than in papillary muscle (stimulation frequency 0.2 Hz). 6. Hydrolytic activity of sarcolemmal Na+,K(+)-ATPase isolated from atria amounted to only one third of that detected in ventricles (0.07 +/- 0.01, n = 6, versus 0.2 +/- 0.01 mumol phosphate released min-1 (g tissue)-1, n = 5). The inhibitory potencies of DHO on sarcolemmal Na+,K(+)-ATPase preparations were found to be identical in the enzymes from either tissue. 7. It is concluded that a lower Na

  1. Culture and Cancer in Kanaka Maoli (Native Hawaiians) Abstract.

    PubMed

    Blaisdell, Richard Kekuni

    1998-01-01

    PURPOSE: To consider the role of culture in the persistently high cancer rates of Kanaka Maoli (Native Hawaiians) in their homeland. METHODS: Historical and recent cancer and other health and socio­economic data and not readily accessible information on Kanaka Maoli and other major ethnicities were analyzed. FINDINGS: In the 1990s, the 205,078 Kanaka Maoli, who comprise 18.8% of the total Ka Pae'aina (Hawaiian Archipelago) population of 1,108,229, continue to have the highest and still rising cancer mortality rates compared to other ethnicities. Rates are higher for piha (pure) Kanaka Maoli than for hapa (mixed) and greater for Kanaka Maoli men over women. The leading cancer sites are lung, breast, stomach, uterus, liver and rectum. Overall five year cancer survival rates for Kanaka Maoli remain shorter than for the other ethnic groups. Kanaka Maoli rank highest for cancer risk factors, such as tobacco use, alcohol use, and obesity; diets high in calories, total fat, saturated fat, cholesterol, processed foods, foods low in fiber, vitamin C, calcium, and folate. Kanaka Maoli continue to have the most unfavorable rates for other leading causes of death, chronic morbidity, suicide, accidents, and other social and economic indicators such as family income, home ownership, schooling, crime and imprisonment. Kanaka Maoli tend to live in rural communities where they comprise 40­90% of the population and where Western health care services are meager and distant. Kanaka Maoli under­utilize Western health care, health promotion and disease prevention services. Kanaka Maoli score poorly in cancer knowledge and tend to have a fatalistic attitude toward cancer. CONCLUSIONS: An interplay of underlying historical, societal and cultural factors, not specific for cancer, nor for ill health, appear to account for the worsening broad plight of Kanaka Maoli. These include: (1) Kanaka Maoli depopulation in