46 CFR 308.543 - Cancellation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 8 2013-10-01 2013-10-01 false Cancellation. 308.543 Section 308.543 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iii-Facultative War Risk Cargo Insurance § 308.543 Cancellation. Facultative war risk insurance is not subject to...

46 CFR 308.543 - Cancellation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 8 2011-10-01 2011-10-01 false Cancellation. 308.543 Section 308.543 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iii-Facultative War Risk Cargo Insurance § 308.543 Cancellation. Facultative war risk insurance is not subject to...

46 CFR 308.543 - Cancellation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Cancellation. 308.543 Section 308.543 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iii-Facultative War Risk Cargo Insurance § 308.543 Cancellation. Facultative war risk insurance is not subject to...

31 CFR 543.303 - Effective date.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Effective date. 543.303 Section 543... Definitions § 543.303 Effective date. The term effective date refers to the effective date of the applicable... § 543.201(a)(2), the earlier of the date of actual or constructive notice of such person's designation. ...

21 CFR 54.3 - Scope.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Scope. 54.3 Section 54.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL FINANCIAL DISCLOSURE BY CLINICAL INVESTIGATORS § 54.3 Scope. The requirements in this part apply to any applicant who submits a marketing...

12 CFR 543.10 - Organization after conversion.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Organization after conversion. 543.10 Section... SAVINGS ASSOCIATIONS-INCORPORATION, ORGANIZATION, AND CONVERSION Conversion § 543.10 Organization after conversion. Except as provided in § 543.11, after a Federal charter is issued under § 543.9 the association's...

12 CFR 543.10 - Organization after conversion.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Organization after conversion. 543.10 Section... SAVINGS ASSOCIATIONS-INCORPORATION, ORGANIZATION, AND CONVERSION Conversion § 543.10 Organization after conversion. Except as provided in § 543.11, after a Federal charter is issued under § 543.9 the association's...

31 CFR 543.310 - United States.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false United States. 543.310 Section 543.310 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... Definitions § 543.310 United States. The term United States means the United States, its territories and...

Alexander the Great's relationship with alcohol.

PubMed

Liappas, J A; Lascaratos, J; Fafouti, S; Christodoulou, G N

2003-05-01

This study sought to clarify if Alexander the Great indulged pathologically in alcohol and whether it contributed to his death. The texts of the historians Diodorus of Sicily, Plutarch, Arrian, Curtius Rufus, Athenaeus, Aelian and Justin were studied, with their information concerning wine consumption by Macedonians, and especially Alexander, and were evaluated. The surviving historical texts, all later than Alexander's epoch, are based on a series of contemporary histories and especially on the 'Royal Journals', an official diary written in the imperial court. Alexander consumed large quantities of undiluted wine periodically, reaching pathological intoxication. However, the existing data do not provide convincing evidence that Alexander the Great manifested abuse of or dependence on alcohol according to DSM-IV or ICD-10 criteria and it seems unlikely that alcohol was involved in his untimely death.

Genetics Home Reference: Alexander disease

MedlinePlus

... the prognosis of a genetic condition? Genetic and Rare Diseases Information Center Frequency The prevalence of Alexander disease ... Degenerative Nerve Diseases Health Topic: Leukodystrophies Genetic and Rare Diseases Information Center (1 link) Alexander disease Additional NIH ...

49 CFR 543.8 - Duration of exemption.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 6 2010-10-01 2010-10-01 false Duration of exemption. 543.8 Section 543.8 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EXEMPTION FROM VEHICLE THEFT PREVENTION STANDARD § 543.8 Duration of...

31 CFR 543.205 - Evasions; attempts; conspiracies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 543.205 Section 543.205 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... Prohibitions § 543.205 Evasions; attempts; conspiracies. (a) Except as otherwise authorized, and...

31 CFR 543.304 - Entity.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Entity. 543.304 Section 543.304 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS... Entity. The term entity means a partnership, association, trust, joint venture, corporation, group...

31 CFR 543.304 - Entity.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 543.304 Section 543.304 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS... Entity. The term entity means a partnership, association, trust, joint venture, corporation, group...

20 CFR 638.543 - Community relations program.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Community relations program. 638.543 Section 638.543 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR JOB CORPS PROGRAM UNDER TITLE IV-B OF THE JOB TRAINING PARTNERSHIP ACT Center Operations § 638.543 Community...

28 CFR 543.15 - Legal aid program.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Legal aid program. 543.15 Section 543.15 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT LEGAL MATTERS Inmate Legal Activities § 543.15 Legal aid program. (a) A legal aid program which is funded or approved...

28 CFR 543.15 - Legal aid program.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Legal aid program. 543.15 Section 543.15 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT LEGAL MATTERS Inmate Legal Activities § 543.15 Legal aid program. (a) A legal aid program which is funded or approved...

28 CFR 543.15 - Legal aid program.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Legal aid program. 543.15 Section 543.15 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT LEGAL MATTERS Inmate Legal Activities § 543.15 Legal aid program. (a) A legal aid program which is funded or approved...

28 CFR 543.15 - Legal aid program.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Legal aid program. 543.15 Section 543.15 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT LEGAL MATTERS Inmate Legal Activities § 543.15 Legal aid program. (a) A legal aid program which is funded or approved...

28 CFR 543.15 - Legal aid program.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Legal aid program. 543.15 Section 543.15 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT LEGAL MATTERS Inmate Legal Activities § 543.15 Legal aid program. (a) A legal aid program which is funded or approved...

31 CFR 543.309 - Transfer.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Transfer. 543.309 Section 543.309 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN... creation or transfer of any lien; the issuance, docketing, filing, or levy of or under any judgment, decree...

38 CFR 18.543 - Mediation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Mediation. 18.543 Section... Enforcement Procedures § 18.543 Mediation. (a) Referral of complaints for mediation. VA will refer to the Federal Mediation and Conciliation Service all complaints that: (1) Fall within the jurisdiction of the...

31 CFR 543.305 - Interest.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Interest. 543.305 Section 543.305....305 Interest. Except as otherwise provided in this part, the term interest, when used with respect to property (e.g., “an interest in property”), means an interest of any nature whatsoever, direct or indirect. ...

31 CFR 543.305 - Interest.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Interest. 543.305 Section 543.305....305 Interest. Except as otherwise provided in this part, the term interest, when used with respect to property (e.g., “an interest in property”), means an interest of any nature whatsoever, direct or indirect. ...

31 CFR 543.305 - Interest.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Interest. 543.305 Section 543.305....305 Interest. Except as otherwise provided in this part, the term interest, when used with respect to property (e.g., “an interest in property”), means an interest of any nature whatsoever, direct or indirect. ...

31 CFR 543.305 - Interest.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Interest. 543.305 Section 543.305....305 Interest. Except as otherwise provided in this part, the term interest, when used with respect to property (e.g., “an interest in property”), means an interest of any nature whatsoever, direct or indirect. ...

31 CFR 543.305 - Interest.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Interest. 543.305 Section 543.305....305 Interest. Except as otherwise provided in this part, the term interest, when used with respect to property (e.g., “an interest in property”), means an interest of any nature whatsoever, direct or indirect. ...

48 CFR 543.205 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 543.205 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 543.205 Contract clauses. The contracting officer shall insert 552.243-71, Equitable Adjustments, in solicitations and contracts containing FAR 52.243-4, Changes. [74 FR...

48 CFR 543.205 - Contract clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 543.205 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 543.205 Contract clauses. The contracting officer shall insert 552.243-71, Equitable Adjustments, in solicitations and contracts containing FAR 52.243-4, Changes. [74 FR...

A psychoanalytic study of Alexander the Great.

PubMed

Thomas, K R

1995-12-01

The purpose of this paper was to demonstrate how Freudian concepts such as the Oedipus complex, castration anxiety, fear of loss of love, the psychosexual stages of development, and the tripartite structure of personality can be used to understand the life and achievements of Alexander the Great. To accomplish this purpose, specific incidents, myths, and relationships in Alexander's life were analyzed from a Freudian psychoanalytic perspective. Green (1991), in his recent biography of Alexander, has questioned the merit of using Freudian concepts to understand Alexander's character. In fact, he stated specifically: If he (Alexander) had any kind of Oedipus complex it came in a poor second to the burning dynastic ambition which Olympias so sedulously fostered in him; those who insist on his psychological motivation would do better to take Adler as their mentor than Freud (p.56). Later, in the concluding section of his book, Green (1991, pp. 486-487) discounted Freudian interpretations of Alexander's distaste for sex, the rumors of his homosexual liaisons, his partiality for middle-aged or elderly ladies, and the systematic domination of his early years by Olympias as little more than the projected fears and desires of the interpreters. And again, an Adlerian power-complex paradigm was suggested as the preferable theoretical framework to use. Green's argument was based primarily on an exchange, reported originally by Plutarch, which took place between Alexander and Philip prior to Alexander's tutorship with Aristotle. Purportedly, Philip enjoined his son to study hard and pay close attention to all Aristotle said "so that you may not do a great many things of the sort that I am sorry I have done." At this point, Alexander "somewhat pertly" took Philip to task "because he was having children by other women besides his wife." Philip's reply was: "Well then, if you have many competitors for the kingdom, prove yourself honorable and good, so that you may obtain the

31 CFR 543.310 - United States.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false United States. 543.310 Section 543.310 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN....310 United States. The term United States means the United States, its territories and possessions...

31 CFR 543.310 - United States.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false United States. 543.310 Section 543.310 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN....310 United States. The term United States means the United States, its territories and possessions...

31 CFR 543.310 - United States.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false United States. 543.310 Section 543.310 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN....310 United States. The term United States means the United States, its territories and possessions...

31 CFR 543.310 - United States.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false United States. 543.310 Section 543.310 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN....310 United States. The term United States means the United States, its territories and possessions...

7 CFR 1944.543 - Grant monitoring.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 13 2010-01-01 2009-01-01 true Grant monitoring. 1944.543 Section 1944.543 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS... monitoring. Each grant will be monitored by FmHA or its successor agency under Public Law 103-354 to ensure...

31 CFR 543.410 - Setoffs prohibited.

Code of Federal Regulations, 2012 CFR

2012-07-01

... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CôTE D'IVOIRE SANCTIONS REGULATIONS Interpretations § 543.410 Setoffs prohibited. A setoff against blocked property (including a blocked account), whether by a U.S. bank or other U.S. person, is a prohibited transfer under § 543.201 if effected after the...

31 CFR 543.410 - Setoffs prohibited.

Code of Federal Regulations, 2011 CFR

2011-07-01

... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CôTE D'IVOIRE SANCTIONS REGULATIONS Interpretations § 543.410 Setoffs prohibited. A setoff against blocked property (including a blocked account), whether by a U.S. bank or other U.S. person, is a prohibited transfer under § 543.201 if effected after the...

31 CFR 543.410 - Setoffs prohibited.

Code of Federal Regulations, 2010 CFR

2010-07-01

... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CôTE D'IVOIRE SANCTIONS REGULATIONS Interpretations § 543.410 Setoffs prohibited. A setoff against blocked property (including a blocked account), whether by a U.S. bank or other U.S. person, is a prohibited transfer under § 543.201 if effected after the...

27 CFR 9.53 - Alexander Valley.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Alexander Valley. 9.53 Section 9.53 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.53 Alexander Valley. (a) Name. The name of the...

27 CFR 9.53 - Alexander Valley.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Alexander Valley. 9.53 Section 9.53 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.53 Alexander Valley. (a) Name. The name of the...

27 CFR 9.53 - Alexander Valley.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Alexander Valley. 9.53 Section 9.53 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.53 Alexander Valley. (a) Name. The name of the...

27 CFR 9.53 - Alexander Valley.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Alexander Valley. 9.53 Section 9.53 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.53 Alexander Valley. (a) Name. The name of the...

27 CFR 9.53 - Alexander Valley.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Alexander Valley. 9.53 Section 9.53 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.53 Alexander Valley. (a) Name. The name of the...

31 CFR 543.308 - Property; property interest.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Property; property interest. 543.308 Section 543.308 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE... or interests therein, present, future or contingent. ...

31 CFR 543.308 - Property; property interest.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Property; property interest. 543.308 Section 543.308 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE... or interests therein, present, future or contingent. ...

31 CFR 543.308 - Property; property interest.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Property; property interest. 543.308 Section 543.308 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE... or interests therein, present, future or contingent. ...

31 CFR 543.308 - Property; property interest.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Property; property interest. 543.308 Section 543.308 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE... or interests therein, present, future or contingent. ...

31 CFR 543.308 - Property; property interest.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Property; property interest. 543.308 Section 543.308 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE... or interests therein, present, future or contingent. ...

9 CFR 54.3 - Animals eligible for indemnity payments.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Animals eligible for indemnity payments. 54.3 Section 54.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... SCRAPIE Scrapie Indemnification Program § 54.3 Animals eligible for indemnity payments. (a) Indemnity may...

9 CFR 54.3 - Animals eligible for indemnity payments.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Animals eligible for indemnity payments. 54.3 Section 54.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... SCRAPIE Scrapie Indemnification Program § 54.3 Animals eligible for indemnity payments. (a) Indemnity may...

9 CFR 54.3 - Animals eligible for indemnity payments.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Animals eligible for indemnity payments. 54.3 Section 54.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... SCRAPIE Scrapie Indemnification Program § 54.3 Animals eligible for indemnity payments. (a) Indemnity may...

9 CFR 54.3 - Animals eligible for indemnity payments.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Animals eligible for indemnity payments. 54.3 Section 54.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... SCRAPIE Scrapie Indemnification Program § 54.3 Animals eligible for indemnity payments. (a) Indemnity may...

9 CFR 54.3 - Animals eligible for indemnity payments.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Animals eligible for indemnity payments. 54.3 Section 54.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... SCRAPIE Scrapie Indemnification Program § 54.3 Animals eligible for indemnity payments. (a) Indemnity may...

Maniac Talk - Alexander Kashlinsky

NASA Image and Video Library

2016-09-30

Alexander Kashlinsky Maniac Lecture, September 30, 2016 Dr. Alexander "Sasha" Kashlinsky, an astronomer/cosmologist working at NASA Goddard presented a Maniac lecture entitled, "HOW I PLANNED TO TRAVEL TO SPACE AND GOT TO STUDY IT INSTEAD: a personal journey through 6 different countries in a changing world." Sasha was born in the former Soviet Union, just as the space era got underway with the Sputnick launch. He traced his journey back to those days of Sputnick, and walked the audience through different stages of his life and career, including his interactions with Lord Martin Rees, one of the world's most eminent astronomer and John Mather, a Nobel Prize in Physics winner.

31 CFR 543.405 - Provision of services.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Provision of services. 543.405 Section 543.405 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE... authorized by or pursuant to this part, provide legal, accounting, financial, brokering, freight forwarding...

28 CFR 543.13 - Visits by attorneys.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Visits by attorneys. 543.13 Section 543.13 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT LEGAL... ordinarily take place during regular visiting hours. Attorney visits shall take place in a private conference...

28 CFR 543.13 - Visits by attorneys.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Visits by attorneys. 543.13 Section 543.13 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT LEGAL... ordinarily take place during regular visiting hours. Attorney visits shall take place in a private conference...

28 CFR 543.13 - Visits by attorneys.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Visits by attorneys. 543.13 Section 543.13 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT LEGAL... ordinarily take place during regular visiting hours. Attorney visits shall take place in a private conference...

25 CFR 543.1 - What does this part cover?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false What does this part cover? 543.1 Section 543.1 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.1 What does this part cover? This part, along with §§ 542.14 through 542...

"Most brilliant in judgment": Alexander the Great and Aristotle.

PubMed

Lainas, Panagiotis; Panutsopulos, Dimitrios; Skandalakis, Panagiotis N; Zoras, Odysseas; Skandalakis, John E

2005-03-01

From historical sources, it is evident that Alexander the Great was indebted to one of his teachers, Aristotle of Stagira. It was the teaching of Aristotle that evoked all the nascent talents of young Alexander and turned him into a great man. Alexander was extremely interested in the secrets of medicine and considered it an art. The medical knowledge he acquired from Aristotle may have saved his life and the lives of his troops on many occasions. If Alexander did not possess medical knowledge and if his everyday life had not been so greatly influenced by medicine, he might never have been able to create his empire.

49 CFR 543.5 - Petition: General requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... § 543.5 Petition: General requirements. (a) For each model year, a manufacturer may petition NHTSA for... manufacturer may not petition NHTSA for an exemption for model years before model year 2006. (b) Each petition... specified under paragraph (5) of § 543.5(b) for the first model year in which the petitioner wishes those...

31 CFR 543.506 - Investment and reinvestment of certain funds.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Investment and reinvestment of certain funds. 543.506 Section 543.506 Money and Finance: Treasury Regulations Relating to Money and... REGULATIONS Licenses, Authorizations and Statements of Licensing Policy § 543.506 Investment and reinvestment...

miR-543 promotes gastric cancer cell proliferation by targeting SIRT1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Juan; Dong, Guoying; Wang, Bo

SIRT1, a class III histone deacetylase, exerts inhibitory effects on tumorigenesis and is downregulated in gastric cancer. However, the role of microRNAs in the regulation of SIRT1 in gastric cancer is still largely unknown. Here, we identified miR-543 as a predicted upstream regulator of SIRT1 using 3 different bioinformatics databases. Mimics of miR-543 significantly inhibited the expression of SIRT1, whereas an inhibitor of miR-543 increased SIRT1 expression. MiR-543 directly targeted the 3′-UTR of SIRT1, and both of the two binding sites contributed to the inhibitory effects. In gastric epithelium-derived cell lines, miR-543 promoted cell proliferation and cell cycle progression, andmore » overexpression of SIRT1 rescued the above effects of miR-543. The inhibitory effects of miR-543 on SIRT1 were also validated using clinical gastric cancer samples. Moreover, we found that miR-543 expression was positively associated with tumor size, clinical grade, TNM stage and lymph node metastasis in gastric cancer patients. Our results identify a new regulatory mechanism of miR-543 on SIRT1 expression in gastric cancer, and raise the possibility that the miR-543/SIRT1 pathway may serve as a potential target for the treatment of gastric cancer. - Highlights: • SIRT1 is a novel target of miR-543. • miR-543 promotes gastric cancer cell proliferation and cell cycle progression by targeting SIRT1. • miR-543 is upregulated in GC and positively associated with tumor size, clinical grade, TNM stage and lymph node metastasis. • miR-543 is negatively correlated with SIRT1 expression in gastric cancer tissues.« less

32 CFR 644.543 - Determination of acceptable offers after advertising.

Code of Federal Regulations, 2010 CFR

2010-07-01

... that further advertising would serve no useful purpose or is not feasible, the DE may negotiate a sale... advertising. 644.543 Section 644.543 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal Sale Procedure § 644.543 Determination of acceptable...

31 CFR 543.506 - Investment and reinvestment of certain funds.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Investment and reinvestment of certain funds. 543.506 Section 543.506 Money and Finance: Treasury Regulations Relating to Money and Finance... Licenses, Authorizations and Statements of Licensing Policy § 543.506 Investment and reinvestment of...

33 CFR 5.43 - Public vessels, aircraft, and radio stations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... radio stations. 5.43 Section 5.43 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL COAST GUARD AUXILIARY § 5.43 Public vessels, aircraft, and radio stations. While assigned... U.S.C. 1301). (c) Any radio station shall be deemed to be a radio station of the United States Coast...

42 CFR 54.3 - Nondiscrimination against religious organizations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Nondiscrimination against religious organizations. 54.3 Section 54.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS CHARITABLE CHOICE REGULATIONS APPLICABLE TO STATES RECEIVING SUBSTANCE ABUSE PREVENTION AND TREATMENT BLOCK...

42 CFR 54.3 - Nondiscrimination against religious organizations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Nondiscrimination against religious organizations. 54.3 Section 54.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS CHARITABLE CHOICE REGULATIONS APPLICABLE TO STATES RECEIVING SUBSTANCE ABUSE PREVENTION AND TREATMENT BLOCK...

42 CFR 54.3 - Nondiscrimination against religious organizations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Nondiscrimination against religious organizations. 54.3 Section 54.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS CHARITABLE CHOICE REGULATIONS APPLICABLE TO STATES RECEIVING SUBSTANCE ABUSE PREVENTION AND TREATMENT BLOCK...

42 CFR 54.3 - Nondiscrimination against religious organizations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Nondiscrimination against religious organizations. 54.3 Section 54.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS CHARITABLE CHOICE REGULATIONS APPLICABLE TO STATES RECEIVING SUBSTANCE ABUSE PREVENTION AND TREATMENT BLOCK...

14 CFR 121.543 - Flight crewmembers at controls.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight crewmembers at controls. 121.543... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Operations § 121.543 Flight crewmembers at controls. (a) Except as provided in paragraph (b) of this section, each required flight crewmember on...

14 CFR 121.543 - Flight crewmembers at controls.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight crewmembers at controls. 121.543... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Operations § 121.543 Flight crewmembers at controls. (a) Except as provided in paragraph (b) of this section, each required flight crewmember on...

14 CFR 121.543 - Flight crewmembers at controls.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight crewmembers at controls. 121.543... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Operations § 121.543 Flight crewmembers at controls. (a) Except as provided in paragraph (b) of this section, each required flight crewmember on...

14 CFR 121.543 - Flight crewmembers at controls.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight crewmembers at controls. 121.543... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Operations § 121.543 Flight crewmembers at controls. (a) Except as provided in paragraph (b) of this section, each required flight crewmember on...

14 CFR 121.543 - Flight crewmembers at controls.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight crewmembers at controls. 121.543... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Operations § 121.543 Flight crewmembers at controls. (a) Except as provided in paragraph (b) of this section, each required flight crewmember on...

31 CFR 543.311 - U.S. financial institution.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false U.S. financial institution. 543.311 Section 543.311 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE..., commodity futures or options, or procuring purchasers and sellers thereof, as principal or agent; including...

31 CFR 543.311 - U.S. financial institution.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false U.S. financial institution. 543.311 Section 543.311 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE..., commodity futures or options, or procuring purchasers and sellers thereof, as principal or agent; including...

31 CFR 543.311 - U.S. financial institution.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false U.S. financial institution. 543.311 Section 543.311 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE..., commodity futures or options, or procuring purchasers and sellers thereof, as principal or agent; including...

31 CFR 543.311 - U.S. financial institution.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false U.S. financial institution. 543.311 Section 543.311 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE..., commodity futures or options, or procuring purchasers and sellers thereof, as principal or agent; including...

31 CFR 543.311 - U.S. financial institution.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false U.S. financial institution. 543.311 Section 543.311 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE..., commodity futures or options, or procuring purchasers and sellers thereof, as principal or agent; including...

49 CFR 543.7 - Processing an exemption petition.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 6 2010-10-01 2010-10-01 false Processing an exemption petition. 543.7 Section... § 543.7 Processing an exemption petition. (a) NHTSA processes any complete petition. If a manufacturer submits a petition that does not contain all the information required by this part, NHTSA informs the...

31 CFR 543.304 - Entity.

Code of Federal Regulations, 2012 CFR

2012-07-01

... CONTROL, DEPARTMENT OF THE TREASURY CôTE D'IVOIRE SANCTIONS REGULATIONS General Definitions § 543.304 Entity. The term entity means a partnership, association, trust, joint venture, corporation, group...

Alexander the Great and West Nile virus encephalitis.

PubMed

Marr, John S; Calisher, Charles H

2003-12-01

Alexander the Great died in Babylon in 323 BC. His death at age 32 followed a 2-week febrile illness. Speculated causes of death have included poisoning; assassination, and a number of infectious diseases. One incident, mentioned by Plutarch but not considered by previous investigators, may shed light on the cause of Alexander's death. The incident, which occurred as he entered Babylon, involved a flock of ravens exhibiting unusual behavior and subsequently dying at his feet. The inexplicable behavior of ravens is reminiscent of avian illness and death weeks before the first human cases of West Nile virus infection were identified in the United States. We posit that Alexander may have died of West Nile virus encephalitis.

Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ju, TongFa; Gao, DaQuan; Fang, Zheng-yu, E-mail: fangzhengyu158@sina.com

In this study, we showed that PF-543, a novel sphingosine kinase 1 (SphK1) inhibitor, exerted potent anti-proliferative and cytotoxic effects against a panel of established (HCT-116, HT-29 and DLD-1) and primary human colorectal cancer (CRC) cells. Its sensitivity was negatively associated with SphK1 expression level in the CRC cells. Surprisingly, PF-543 mainly induced programmed necrosis, but not apoptosis, in the CRC cells. CRC cell necrotic death was detected by lactate dehydrogenase (LDH) release, mitochondrial membrane potential (MMP) collapse and mitochondrial P53-cyclophilin-D (Cyp-D) complexation. Correspondingly, the necrosis inhibitor necrostatin-1 largely attenuated PF-543-induced cytotoxicity against CRC cells. Meanwhile, the Cyp-D inhibitors (sanglifehrinmore » A and cyclosporin A), or shRNA-mediated knockdown of Cyp-D, remarkably alleviated PF-543-induced CRC cell necrotic death. Reversely, over-expression of wild-type Cyp-D in HCT-116 cells significantly increased PF-543's sensitivity. In vivo, PF-543 intravenous injection significantly suppressed HCT-116 xenograft growth in severe combined immunodeficient (SCID) mice, whiling remarkably improving the mice survival. The in vivo activity by PF-543 was largely attenuated when combined with the Cyp-D inhibitor cyclosporin A. Collectively, our results demonstrate that PF-543 exerts potent anti-CRC activity in vitro and in vivo. Mitochondrial programmed necrosis pathway is likely the key mechanism responsible for PF-543's actions in CRC cells. - Highlights: • PF-543 is anti-proliferative and cytotoxic to established and primary CRC cells. • PF-543 induces programmed necrosis, but not apoptosis, in CRC cells. • Modulation of mitochondrial protein cyclophilin-D alters PF-543's sensitivity. • PF-543 inhibits HCT-116 xenograft growth in SCID mice, improving mice survival. • Co-administration of cyclophilin-D inhibitor CsA inhibits PF-543's activity in vivo.« less

A complex-network perspective on Alexander's wholeness

NASA Astrophysics Data System (ADS)

Jiang, Bin

2016-12-01

The wholeness, conceived and developed by Christopher Alexander, is what exists to some degree or other in space and matter, and can be described by precise mathematical language. However, it remains somehow mysterious and elusive, and therefore hard to grasp. This paper develops a complex network perspective on the wholeness to better understand the nature of order or beauty for sustainable design. I bring together a set of complexity-science subjects such as complex networks, fractal geometry, and in particular underlying scaling hierarchy derived by head/tail breaks - a classification scheme and a visualization tool for data with a heavy-tailed distribution, in order to make Alexander's profound thoughts more accessible to design practitioners and complexity-science researchers. Through several case studies (some of which Alexander studied), I demonstrate that the complex-network perspective helps reduce the mystery of wholeness and brings new insights to Alexander's thoughts on the concept of wholeness or objective beauty that exists in fine and deep structure. The complex-network perspective enables us to see things in their wholeness, and to better understand how the kind of structural beauty emerges from local actions guided by the 15 fundamental properties, and in particular by differentiation and adaptation processes. The wholeness goes beyond current complex network theory towards design or creation of living structures.

44 CFR 5.43 - Waiver or reduction of fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Waiver or reduction of fees. 5.43 Section 5.43 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY... requester's and/or intended user's identity and qualifications, expertise in the subject area and ability...

Dr Elizabeth Alexander: First Female Radio Astronomer

NASA Astrophysics Data System (ADS)

Orchiston, Wayne

2005-01-01

During March-April 1945, solar radio emission was detected at 200 MHz by operators of a Royal New Zealand Air Force radar unit located on Norfolk Island. Initially dubbed the `Norfolk Island Effect', this anomalous radiation was investigated throughout 1945 by British-born Elizabeth Alexander, head of the Operational Research Section of the Radio Development Laboratory in New Zealand. Alexander prepared a number of reports on this work, and in early 1946 she published a short paper in the newly-launched journal, Radio & Electronics. A geologist by training, Elizabeth Alexander happened to be in the right place at the right time, and unwittingly became the first woman in the world to work in the field that would later become known as radio astronomy. Her research also led to further solar radio astronomy projects in New Zealand in the immediate post-war year, and in part was responsible for the launch of the radio astronomy program at the Division of Radiophysics, CSIRO, in Sydney.

26 CFR 1.543-1 - Personal holding company income.

Code of Federal Regulations, 2011 CFR

2011-04-01

... prevent evasion of taxes or clearly to reflect the income of any such organizations, trades, or businesses... 1.543-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Personal Holding Companies § 1.543-1 Personal holding company income. (a...

30 CFR 285.543 - Example of how the inverse distance formula works.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Example of how the inverse distance formula works. 285.543 Section 285.543 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... Financial Assurance Requirements Revenue Sharing with States § 285.543 Example of how the inverse distance...

31 CFR 543.301 - Arms or any related materiel.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Arms or any related materiel. 543.301... Definitions § 543.301 Arms or any related materiel. The term arms or any related materiel means arms or... of arms and related materiel and technical training and assistance intended solely for support of or...

31 CFR 543.301 - Arms or any related materiel.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Arms or any related materiel. 543.301... Definitions § 543.301 Arms or any related materiel. The term arms or any related materiel means arms or... of arms and related materiel and technical training and assistance intended solely for support of or...

31 CFR 543.301 - Arms or any related materiel.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Arms or any related materiel. 543.301... Definitions § 543.301 Arms or any related materiel. The term arms or any related materiel means arms or... of arms and related materiel and technical training and assistance intended solely for support of or...

31 CFR 543.301 - Arms or any related materiel.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Arms or any related materiel. 543.301... Definitions § 543.301 Arms or any related materiel. The term arms or any related materiel means arms or... of arms and related materiel and technical training and assistance intended solely for support of or...

Alexander's (356-323 BC) expeditionary Medical Corps 334-323 BC.

PubMed

Retsas, Spyros

2009-08-01

Alexander had a profound interest in medicine and healing. Original Greek texts survive mainly from the works of Plutarch and Arrian. This paper examines original sources naming the physicians who participated in Alexander's expedition in Asia, the battle injuries he sustained and his final illness in Babylon.

49 CFR 543.2 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF TRANSPORTATION EXEMPTION FROM VEHICLE THEFT PREVENTION STANDARD § 543.2 Purpose. The purpose of... passenger motor vehicles to obtain an exemption from the parts-marking requirements of the vehicle theft... motor vehicle theft as compliance with the parts-marking requirements. This part also provides the...

12. Detail view of southeast side window of AlexanderAlmon House ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Detail view of southeast side window of Alexander-Almon House with rain barrel at lower left and roof rafter tails at top, facing northwest. - Alexander-Almon House, 130 Philip Almon Road, Roopville, Carroll County, GA

31 CFR 543.312 - United States person; U.S. person.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false United States person; U.S. person. 543.312 Section 543.312 Money and Finance: Treasury Regulations Relating to Money and Finance.... person means any United States citizen, permanent resident alien, entity organized under the laws of the...

31 CFR 543.312 - United States person; U.S. person.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false United States person; U.S. person. 543.312 Section 543.312 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... any United States citizen, permanent resident alien, entity organized under the laws of the United...

31 CFR 543.312 - United States person; U.S. person.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false United States person; U.S. person. 543.312 Section 543.312 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... any United States citizen, permanent resident alien, entity organized under the laws of the United...

31 CFR 543.312 - United States person; U.S. person.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false United States person; U.S. person. 543.312 Section 543.312 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... any United States citizen, permanent resident alien, entity organized under the laws of the United...

33 CFR 162.250 - Port Alexander, Alaska; speed of vessels.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Port Alexander, Alaska; speed of... Alexander, Alaska; speed of vessels. (a) Definition. The term “Port Alexander” includes the entire inlet from its head to its entrance from Chatham Strait. (b) Speed. The speed of all vessels of 5 tons or...

33 CFR 162.250 - Port Alexander, Alaska; speed of vessels.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Port Alexander, Alaska; speed of... Alexander, Alaska; speed of vessels. (a) Definition. The term “Port Alexander” includes the entire inlet from its head to its entrance from Chatham Strait. (b) Speed. The speed of all vessels of 5 tons or...

25 CFR 162.543 - May permanent improvements be made under a WSR lease?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false May permanent improvements be made under a WSR lease? 162.543 Section 162.543 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Leases § 162.543 May permanent improvements be made...

25 CFR 162.543 - May permanent improvements be made under a WSR lease?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false May permanent improvements be made under a WSR lease? 162.543 Section 162.543 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Leases § 162.543 May permanent improvements be made...

25 CFR 543.8 - What are the minimum internal control standards for bingo?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 2 2014-04-01 2014-04-01 false What are the minimum internal control standards for bingo? 543.8 Section 543.8 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.8 What are the minimum internal control standards for bingo? (a) Supervision....

25 CFR 543.8 - What are the minimum internal control standards for bingo?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false What are the minimum internal control standards for bingo? 543.8 Section 543.8 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.8 What are the minimum internal control standards for bingo? (a) Supervision....

The efficacy of medicine during the campaigns of Alexander the Great.

PubMed

Ruffin, J R

1992-09-01

This paper examines the various factors that may have determined the efficacy of physicians during the campaigns of Alexander the Great. Such general variables as the adequacy of preparation, the nature of the medical profession, and the extent of preventative measures are all discussed at the outset of the paper, followed by a more detailed examination of the specific wounds, illnesses, and treatments of Alexander as described in the accounts of the Alexander historians Plutarch, Curtius, and Arrian. Where no remedy is given by these writers (as is usually the case), this paper speculates on the efficacy of possible treatments as advocated in the contemporary Hippocratic corpus. Casualty statistics of the campaigns are compared to a similar review of Homer's Iliad. From these examinations, this paper concludes that wound treatment efficacy was significantly greater than that of illness treatment, and that Alexander lost many more men to disease than to the wounds of war.

31 CFR 543.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Holding of funds in interest-bearing accounts; investment and reinvestment. 543.203 Section 543.203 Money and Finance: Treasury Regulations...´TE D'IVOIRE SANCTIONS REGULATIONS Prohibitions § 543.203 Holding of funds in interest-bearing...

31 CFR 543.409 - Credit extended and cards issued by U.S. financial institutions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Credit extended and cards issued by U.S. financial institutions. 543.409 Section 543.409 Money and Finance: Treasury Regulations Relating...'IVOIRE SANCTIONS REGULATIONS Interpretations § 543.409 Credit extended and cards issued by U.S. financial...

31 CFR 543.409 - Credit extended and cards issued by U.S. financial institutions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Credit extended and cards issued by U.S. financial institutions. 543.409 Section 543.409 Money and Finance: Treasury Regulations Relating...'IVOIRE SANCTIONS REGULATIONS Interpretations § 543.409 Credit extended and cards issued by U.S. financial...

31 CFR 543.409 - Credit extended and cards issued by U.S. financial institutions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Credit extended and cards issued by U.S. financial institutions. 543.409 Section 543.409 Money and Finance: Treasury Regulations Relating...'IVOIRE SANCTIONS REGULATIONS Interpretations § 543.409 Credit extended and cards issued by U.S. financial...

31 CFR 543.409 - Credit extended and cards issued by U.S. financial institutions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Credit extended and cards issued by U.S. financial institutions. 543.409 Section 543.409 Money and Finance: Treasury Regulations Relating...'IVOIRE SANCTIONS REGULATIONS Interpretations § 543.409 Credit extended and cards issued by U.S. financial...

Alexander Falconer Sr Seamen's missionary in New Zealand, son Alexander Falconer medical superintendent for mentally ill, grandson Murray Falconer neurosurgeon.

PubMed

Hawgood, Barbara J

2016-08-01

Alexander Falconer Sr (1843-1915) came from Scotland to New Zealand. A practical Christian, he set up places of relaxation for miners, sailors and soldiers; he became the Seamen's Missionary. Son, Dr Alexander Falconer (1874-1955) trained at Otago University Medical School. As medical superintendent for the mentally ill, he urged the early introduction of psychotherapy. His son, Murray Falconer (1910-1977) was the first Nuffield Dominions Clinical Fellow, training in neurosurgery in Oxford. He was the first director of the Guy's-Maudsley Neurosurgical Unit in London and was internationally known for the surgical management of temporal lobe epilepsy in adults and children. © The Author(s) 2016.

78 FR 30791 - Airworthiness Directives; Alexander Schleicher GmbH & Co. Segelflugzeugbau Sailplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-23

... Schleicher GmbH & Co. Segelflugzeugbau Sailplanes AGENCY: Federal Aviation Administration (FAA), Department... new airworthiness directive (AD) for all Alexander Schleicher GmbH & Co. Segelflugzeugbau Models AS... proposed AD, contact Alexander Schleicher GmbH & Co Segelflugzeugbau, Stra[szlig]e 1 D-- 36163 Poppenhausen...

The Haunting Influence of Alexander Graham Bell

ERIC Educational Resources Information Center

Mitchell, Sue H.

1971-01-01

The article examines the significance that Alexander Graham Bell's attitude and actions had on the social and economic conditions experienced by deaf people during his lifetime and into the present. (CD)

25 CFR 543.9 - What are the minimum internal control standards for pull tabs?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false What are the minimum internal control standards for pull tabs? 543.9 Section 543.9 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.9 What are the minimum internal control standards for pull tabs? (a)...

25 CFR 543.9 - What are the minimum internal control standards for pull tabs?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 2 2014-04-01 2014-04-01 false What are the minimum internal control standards for pull tabs? 543.9 Section 543.9 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.9 What are the minimum internal control standards for pull tabs? (a)...

Alexander Disease: A Novel Mutation in GFAP Leading to Epilepsia Partialis Continua.

PubMed

Bonthius, Daniel J; Karacay, Bahri

2016-06-01

Alexander disease is a genetically induced leukodystrophy, due to dominant mutations in the glial fibrillary acidic protein (GFAP ) gene, causing dysfunction of astrocytes. We have identified a novel GFAP mutation, associated with a novel phenotype for Alexander disease. A boy with global developmental delay and hypertonia was found to have a leukodystrophy. Genetic analysis revealed a heterozygous point mutation in exon 6 of the GFAP gene. The guanine-to-adenine change causes substitution of the normal glutamic acid codon (GAG) with a mutant lysine codon (AAG) at position 312 (E312 K mutation). At the age of 4 years, the child developed epilepsia partialis continua, consisting of unabating motor seizures involving the unilateral perioral muscles. Epilepsia partialis continua has not previously been reported in association with Alexander disease. Whether and how the E312 K mutation produces pathologic changes and clinical signs that are unique from other Alexander disease-inducing mutations in GFAP remain to be determined. © The Author(s) 2015.

A Study of Combined Arms Warfare by Alexander the Great.

DTIC Science & Technology

1998-06-05

source of Greek literature written about Alexander is from the famous biographer Plutarch . He wrote the Life of Alexander in the second century C.E...emperor Trajan, was appointed governor of Greece for a short time, and like Arrian, also served as Archon. It was in his later years that Plutarch began...and heavy troops were positioned by their territory behind the main battle line. According to Arrian and Plutarch , 41 Darius’ army at this time

45 CFR 5.43 - Fee schedule.

Code of Federal Regulations, 2010 CFR

2010-10-01

... DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION FREEDOM OF INFORMATION REGULATIONS Fees § 5.43... punchcards or blueprints), or reproducing other records (such as tapes)—the actual costs of operating the... service is not required by the FOIA. If we agree to provide it, we will charge $10 per certification. (f...

30 CFR 585.543 - Example of how the inverse distance formula works.

Code of Federal Regulations, 2014 CFR

2014-07-01

... works. 585.543 Section 585.543 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF... inverse distance formula works. (a) Assume that the geographic center of the project area lies 12 miles...

30 CFR 585.543 - Example of how the inverse distance formula works.

Code of Federal Regulations, 2013 CFR

2013-07-01

... works. 585.543 Section 585.543 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF... inverse distance formula works. (a) Assume that the geographic center of the project area lies 12 miles...

30 CFR 285.543 - Example of how the inverse distance formula works.

Code of Federal Regulations, 2011 CFR

2011-07-01

... works. 285.543 Section 285.543 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON THE... project area lies 12 miles from the closest coastline point of State A and 4 miles from the closest...

30 CFR 585.543 - Example of how the inverse distance formula works.

Code of Federal Regulations, 2012 CFR

2012-07-01

... works. 585.543 Section 585.543 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF... inverse distance formula works. (a) Assume that the geographic center of the project area lies 12 miles...

Alexander the Great and West Nile Virus Encephalitis

PubMed Central

Marr, John S.

2003-01-01

Alexander the Great died in Babylon in 323 BC. His death at age 32 followed a 2-week febrile illness. Speculated causes of death have included poisoning, assassination, and a number of infectious diseases. One incident, mentioned by Plutarch but not considered by previous investigators, may shed light on the cause of Alexander’s death. The incident, which occurred as he entered Babylon, involved a flock of ravens exhibiting unusual behavior and subsequently dying at his feet. The inexplicable behavior of ravens is reminiscent of avian illness and death weeks before the first human cases of West Nile virus infection were identified in the United States. We posit that Alexander may have died of West Nile encephalitis. PMID:14725285

31 CFR 543.303 - Effective date.

Code of Federal Regulations, 2012 CFR

2012-07-01

... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CôTE D'IVOIRE SANCTIONS REGULATIONS General... prohibitions and directives contained in this part as follows: (a) With respect to a person whose property and interests in property are blocked pursuant to § 543.201(a)(1), 12:01 a.m. eastern standard time, February 8...

25 CFR 543.17 - What are the minimum internal control standards for drop and count?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false What are the minimum internal control standards for drop and count? 543.17 Section 543.17 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.17 What are the minimum internal control standards for drop and count?...

25 CFR 543.15 - What are the minimum internal control standards for lines of credit?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false What are the minimum internal control standards for lines of credit? 543.15 Section 543.15 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.15 What are the minimum internal control standards for lines of credi...

25 CFR 543.15 - What are the minimum internal control standards for lines of credit?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 2 2014-04-01 2014-04-01 false What are the minimum internal control standards for lines of credit? 543.15 Section 543.15 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.15 What are the minimum internal control standards for lines of credi...

25 CFR 543.17 - What are the minimum internal control standards for drop and count?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 2 2014-04-01 2014-04-01 false What are the minimum internal control standards for drop and count? 543.17 Section 543.17 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.17 What are the minimum internal control standards for drop and count?...

LP 543-25: A Rare Low-mass Runaway Disk Star

NASA Astrophysics Data System (ADS)

de la Fuente Marcos, Raúl; de la Fuente Marcos, Carlos

2018-05-01

LP 543-25 or PSS 544-7 is a high proper-motion star located 458 pc from the Sun in the constellation of Canis Minor; it has been argued that it could be a candidate cannonball star ejected by a star cluster. Here, we revisit the issue of the kinematics of this interesting star using Gaia DR2. The heliocentric Galactic velocity components are (U, V, W) = (206, -289, 30) km/s; the corresponding Galactocentric Galactic velocity components show that LP 543-25 is moving in the Galactic plane and away from the Galactic Center at a rate of nearly 200 km/s, which is compatible with an origin in one of the multiple star clusters that inhabit the inner regions of the Milky Way. LP 543-25 appears to be a member of an elusive class of stars, the low-mass runaway stars. It is perhaps one of the closest and less massive runaway stars identified so far.

25 CFR 543.20 - What are the minimum internal control standards for information technology and information...

Code of Federal Regulations, 2013 CFR

2013-04-01

... information technology and information technology data? 543.20 Section 543.20 Indians NATIONAL INDIAN GAMING... § 543.20 What are the minimum internal control standards for information technology and information... prevent the concealment of fraud. (4) Information technology agents having access to Class II gaming...

25 CFR 543.20 - What are the minimum internal control standards for information technology and information...

Code of Federal Regulations, 2014 CFR

2014-04-01

... information technology and information technology data? 543.20 Section 543.20 Indians NATIONAL INDIAN GAMING... § 543.20 What are the minimum internal control standards for information technology and information... prevent the concealment of fraud. (4) Information technology agents having access to Class II gaming...

Alexander Archipelago, Southeastern Alaska

NASA Technical Reports Server (NTRS)

2002-01-01

West of British Columbia, Canada, and south of the Yukon Territory, the southeastern coastline of Alaska trails off into the islands of the Alexander Archipelago. The area is rugged and contains many long, U-shaped, glaciated valleys, many of which terminate at tidewater. The Alexander Archipelago is home to Glacier Bay National Park. The large bay that has two forks on its northern end is Glacier Bay itself. The eastern fork is Muir inlet, into which runs the Muir glacier, named for the famous Scottish-born naturalist John Muir. Glacier Bay opens up into the Icy Strait. The large, solid white area to the west is Brady Icefield, which terminates at the southern end in Brady's Glacier. To locate more interesting features from Glacier Bay National Park, take a look at the park service map. As recently as two hundred years ago, a massive ice field extended into Icy Strait and filled the Glacier Bay. Since that time, the area has experienced rapid deglaciation, with many large glaciers retreating 40, 60, even 80 km. While temperatures have increased in the region, it is still unclear whether the rapid recession is part of the natural cycle of tidewater glaciers or is an indicator of longer-term climate change. For more on Glacier Bay and climate change, read an online paper by Dr. Dorothy Hall, a MODIS Associate Science Team Member. Credit: Jacques Descloitres, MODIS Land Rapid Response Team, NASA/GSFC

The Berlin tradition in Chicago: Franz Alexander and the Chicago Institute for Psychoanalysis.

PubMed

Schmidt, Erika S

2010-01-01

Freud considered Franz Alexander, the first graduate of the Berlin Psychoanalytic Institute and an assistant in the Berlin Polyclinic, to be "one of our strongest hopes for the future." Alexander went on to become the first director of the Chicago Institute for Psychoanalysis in 1932 and modeled some of the Chicago Institute's mission on his Berlin experiences. He was also a researcher in psychosomatic medicine, a prolific writer about psychoanalysis and prominent in psychoanalytic organizations. As he proposed modifications in psychoanalytic technique, he became a controversial figure, especially in the elaboration of his ideas about brief therapy and the corrective emotional experience. This paper puts Alexander's achievements in historical context, draws connections between the Berlin and Chicago Institutes and suggests that, despite his quarrels with traditional psychoanalysis, Alexander's legacy may be in his attitude towards psychoanalysis, characterized by a commitment to scientific study, a willingness to experiment, and a conviction about the role of psychoanalysis within the larger culture.

25 CFR 543.16 - What are the minimum internal controls for information technology?

Code of Federal Regulations, 2010 CFR

2010-04-01

... technology? 543.16 Section 543.16 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN... controls for information technology? (a) Physical security measures restricting access to agents, including... longer required. (2) In the event of remote access, the information technology employees must prepare a...

49 CFR 543.5 - Petition: General requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

....5 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC... § 543.5 Petition: General requirements. (a) For each model year, a manufacturer may petition NHTSA for... manufacturer may not petition NHTSA for an exemption for model years before model year 2006. (b) Each petition...

The Remarkable Journey of Lloyd Alexander

ERIC Educational Resources Information Center

Tunnel, Michael O.; Jacobs, James S.

2007-01-01

This article features Lloyd Alexander, an author who has produced some of the most elegant and powerful prose in the history of modern children's literature. Lloyd began writing seriously in high school, and though he wrote and submitted many poems and short stories, his only success was being named a finalist in the "Writer's Digest" Short Story…

25 CFR 543.21 - What are the minimum internal control standards for surveillance?

Code of Federal Regulations, 2013 CFR

2013-04-01

... surveillance? 543.21 Section 543.21 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN... control standards for surveillance? (a) Supervision. Supervision must be provided as needed for surveillance by an agent(s) with authority equal to or greater than those being supervised. (b) Surveillance...

25 CFR 543.21 - What are the minimum internal control standards for surveillance?

Code of Federal Regulations, 2014 CFR

2014-04-01

... surveillance? 543.21 Section 543.21 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN... control standards for surveillance? (a) Supervision. Supervision must be provided as needed for surveillance by an agent(s) with authority equal to or greater than those being supervised. (b) Surveillance...

Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease.

PubMed

Wang, Liqun; Xia, Jing; Li, Jonathan; Hagemann, Tracy L; Jones, Jeffrey R; Fraenkel, Ernest; Weitz, David A; Zhang, Su-Chun; Messing, Albee; Feany, Mel B

2018-05-15

Glial cells have increasingly been implicated as active participants in the pathogenesis of neurological diseases, but critical pathways and mechanisms controlling glial function and secondary non-cell autonomous neuronal injury remain incompletely defined. Here we use models of Alexander disease, a severe brain disorder caused by gain-of-function mutations in GFAP, to demonstrate that misregulation of GFAP leads to activation of a mechanosensitive signaling cascade characterized by activation of the Hippo pathway and consequent increased expression of A-type lamin. Importantly, we use genetics to verify a functional role for dysregulated mechanotransduction signaling in promoting behavioral abnormalities and non-cell autonomous neurodegeneration. Further, we take cell biological and biophysical approaches to suggest that brain tissue stiffness is increased in Alexander disease. Our findings implicate altered mechanotransduction signaling as a key pathological cascade driving neuronal dysfunction and neurodegeneration in Alexander disease, and possibly also in other brain disorders characterized by gliosis.

25 CFR 543.13 - What are the minimum internal control standards for complimentary services or items?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false What are the minimum internal control standards for complimentary services or items? 543.13 Section 543.13 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.13 What are the minimum internal control standards fo...

25 CFR 543.13 - What are the minimum internal control standards for complimentary services or items?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 2 2014-04-01 2014-04-01 false What are the minimum internal control standards for complimentary services or items? 543.13 Section 543.13 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.13 What are the minimum internal control standards fo...

The Alexander Archipelago wolf: a conservation assessment.

Treesearch

David K. Person; Matthew Kirchhoff; Victor van Ballenberghe; George C. Iverson; Edward Grossman

1996-01-01

We summarized the scientific information available for the Alexander Archipelago wolf (Canis lupus ligoni) in the Tongass National Forest of southeast Alaska. Information concerning the morphology, distribution, taxonomy, genetics, and ecology of wolves are presented. Three issues for the conservation of wolves in southeast Alaska are discussed:...

Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1.

PubMed

Hu, Xiaojing; Chi, Liyi; Zhang, Wentao; Bai, Tiao; Zhao, Wei; Feng, Zhanbin; Tian, Hongyan

2015-12-25

Insulin resistance plays an important role in the development of hypertension, which is seriously detrimental to human health. Recently, Sirtuin-1 (SIRT1) has been found to participate in regulation of insulin resistance. Therefore, further studies focused on the SIRT1 regulators might provide a potential approach for combating insulin resistance and hypertension. Interestingly, in this study, we found that SIRT1 was the target gene of the miR-543 by the Dual-Luciferase Reporter Assay. Moreover, the miR-543 expression notably increased in the insulin-resistant HepG2 cells induced by TNF-α. Further analysis showed that the overexpression of the miR-543 lowered the SIRT1 mRNA and protein levels, resulting in the insulin resistance in the HepG2 cells; the inhibition of miR-543, however, enhanced the mRNA and protein expression of the SIRT1, and alleviated the insulin resistance. Furthermore, the SIRT1 overexpression abrogated the effect of miR-543 on insulin resistance. In addition, the overexpression of the miR-543 by the lentivirus-mediated gene transfer markedly impaired the insulin signaling assessed by the Western blot analysis of the glycogen synthesis and the phosphorylation of Akt and GSK3β. In summary, our study suggested that the downregulation of the miR-543 could alleviate the insulin resistance via the modulation of the SIRT1 expression, which might be a potential new strategy for treating insulin resistance and a promising therapeutic method for hypertension. Copyright © 2015 Elsevier Inc. All rights reserved.

31 CFR 543.101 - Relation of this part to other laws and regulations.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Relation of this part to other laws and regulations. 543.101 Section 543.101 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CÃTE D'IVOIRE SANCTIONS...

31 CFR 543.101 - Relation of this part to other laws and regulations.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Relation of this part to other laws and regulations. 543.101 Section 543.101 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CÃTE D'IVOIRE SANCTIONS...

31 CFR 543.101 - Relation of this part to other laws and regulations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Relation of this part to other laws and regulations. 543.101 Section 543.101 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CôTE D'IVOIRE SANCTIONS...

31 CFR 543.101 - Relation of this part to other laws and regulations.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Relation of this part to other laws and regulations. 543.101 Section 543.101 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CôTE D'IVOIRE SANCTIONS...

31 CFR 543.101 - Relation of this part to other laws and regulations.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Relation of this part to other laws and regulations. 543.101 Section 543.101 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CôTE D'IVOIRE SANCTIONS...

Holocene morphogenesis of Alexander the Great's isthmus at Tyre in Lebanon

PubMed Central

Marriner, Nick; Morhange, Christophe; Meulé, Samuel

2007-01-01

In 332 B.C., Alexander the Great constructed an ≈1,000-m-long causeway to seize the offshore island of Tyre. The logistics behind this engineering feat have long troubled archaeologists. Using the Holocene sedimentary record, we demonstrate that Alexander's engineers cleverly exploited a shallow proto-tombolo, or sublittoral sand spit, to breach the offshore city's defensive impregnability. We elucidate a three-phase geomorphological model for the spit's evolution. Settled since the Bronze Age, the area's geological record manifests a long history of natural and anthropogenic forcings. (i) Leeward of the island breakwater, the maximum flooding surface (e.g., drowning of the subaerial land surfaces by seawater) is dated ≈8000 B.P. Fine-grained sediments and brackish and marine-lagoonal faunas translate shallow, low-energy water bodies at this time. Shelter was afforded by Tyre's elongated sandstone reefs, which acted as a 6-km natural breakwater. (ii) By 6000 B.P., sea-level rise had reduced the dimensions of the island from 6 to 4 km. The leeward wave shadow generated by this island, allied with high sediment supply after 3000 B.P., culminated in a natural wave-dominated proto-tombolo within 1–2 m of mean sea level by the time of Alexander the Great (4th century B.C.). (iii) After 332 B.C., construction of Alexander's causeway entrained a complete anthropogenic metamorphosis of the Tyrian coastal system. PMID:17517668

Holocene morphogenesis of Alexander the Great's isthmus at Tyre in Lebanon.

PubMed

Marriner, Nick; Morhange, Christophe; Meulé, Samuel

2007-05-29

In 332 B.C., Alexander the Great constructed an approximately 1,000-m-long causeway to seize the offshore island of Tyre. The logistics behind this engineering feat have long troubled archaeologists. Using the Holocene sedimentary record, we demonstrate that Alexander's engineers cleverly exploited a shallow proto-tombolo, or sublittoral sand spit, to breach the offshore city's defensive impregnability. We elucidate a three-phase geomorphological model for the spit's evolution. Settled since the Bronze Age, the area's geological record manifests a long history of natural and anthropogenic forcings. (i) Leeward of the island breakwater, the maximum flooding surface (e.g., drowning of the subaerial land surfaces by seawater) is dated approximately 8000 B.P. Fine-grained sediments and brackish and marine-lagoonal faunas translate shallow, low-energy water bodies at this time. Shelter was afforded by Tyre's elongated sandstone reefs, which acted as a 6-km natural breakwater. (ii) By 6000 B.P., sea-level rise had reduced the dimensions of the island from 6 to 4 km. The leeward wave shadow generated by this island, allied with high sediment supply after 3000 B.P., culminated in a natural wave-dominated proto-tombolo within 1-2 m of mean sea level by the time of Alexander the Great (4th century B.C.). (iii) After 332 B.C., construction of Alexander's causeway entrained a complete anthropogenic metamorphosis of the Tyrian coastal system.

Kinesthetic Ventures Informed by the Work of F. M. Alexander, Stanislavski, Peirce, and Freud.

ERIC Educational Resources Information Center

Bouchard, Ed; Wright, Ben; Protzel, Michael, Ed.

This book is about education harvested from self-observation. F. Matthias Alexander (1869-1955) studied the experience of self formation, working with motor habits. His method is used in performing arts training to enhance bodily and vocal expression. Like Alexander, Konstantine Stanislavski (1863-1938) and Sigmund Freud (1856-1939) studied human…

25 CFR 543.6 - Does this part apply to small and charitable gaming operations?

Code of Federal Regulations, 2010 CFR

2010-04-01

... operations? 543.6 Section 543.6 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN...) Protect the integrity of games offered; (ii) Safeguard the assets used in connection with the operation... the integrity of the games offered; (ii) Safeguard the assets used in connection with the gaming...

25 CFR 543.10 - What are the minimum internal control standards for card games?

Code of Federal Regulations, 2013 CFR

2013-04-01

... games? 543.10 Section 543.10 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN... control standards for card games? (a) Supervision. Supervision must be provided as needed during the card... personnel independent of the transaction or independent of the card games department; or (2) A dealer may...

25 CFR 543.10 - What are the minimum internal control standards for card games?

Code of Federal Regulations, 2014 CFR

2014-04-01

... games? 543.10 Section 543.10 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN... control standards for card games? (a) Supervision. Supervision must be provided as needed during the card... personnel independent of the transaction or independent of the card games department; or (2) A dealer may...

31 CFR 543.508 - Authorization of emergency medical services.

Code of Federal Regulations, 2011 CFR

2011-07-01

... (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CôTE D'IVOIRE SANCTIONS REGULATIONS... property and interests in property are blocked pursuant to § 543.201(a) is authorized, provided that all...

31 CFR 543.508 - Authorization of emergency medical services.

Code of Federal Regulations, 2012 CFR

2012-07-01

... (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CôTE D'IVOIRE SANCTIONS REGULATIONS... property and interests in property are blocked pursuant to § 543.201(a) is authorized, provided that all...

31 CFR 543.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... are invested in a money market fund or in U.S. Treasury bills. (2) For purposes of this section, a... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Holding of funds in interest-bearing accounts; investment and reinvestment. 543.203 Section 543.203 Money and Finance: Treasury Regulations...

Alexander the Great's Tomb at Siwa: The Astronomical Orientation

NASA Astrophysics Data System (ADS)

Papathanassiou, M.; Souvaltzis, Em.; Souvaltzi, L.; Moussas, X.

A preliminary report on the possible astronomical orientation of the Tomb of Alexander the Great, recently found and excavated by the greek archaeologist Liana Souvaltzi. The tomb is a greek building of doric style. Its enormous dimensions make it the largest amongst the found macedonian tombs (much bigger than the tomb of Philip II, Alexander's father). The tomb faces generally south---west and its orientation could be related either to the constellation of Centaurus or to the star Canopus. The walls of the two long sides of the building have strickingly different widhts. Moreover each wall has three doors (opposite in pairs) of slightly different sizes. We examine the possibility the openings of the doors and their assymetries to be designed and constructed according to some astronomical (solar or stellar) orientations.

Alexander George Karczmar (1917-2017).

PubMed

Soreq, Hermona; Silman, Israel

2017-12-01

The neurochemistry community at large and the Advisory Board of The International Symposia on Cholinergic Mechanisms mourn the loss of Alexander George Karczmar, the elected Honorary President of these international symposia, who passed away peacefully in his Chicago home at the age of 100 on August 17, 2017. For many of us Alex was the essence of cholinergic signaling, and personified its versatile power to send messages between the brain and the peripheral tissues and organs, and to connect between body and soul. © 2017 International Society for Neurochemistry.

3. Historic American Buildings Survey J. Alexander, Photographer, 1971 DETAIL, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Historic American Buildings Survey J. Alexander, Photographer, 1971 DETAIL, ENTRANCE STOOP (LION FIGURE) - Joseph Beale House, 2301 Massachusetts Avenue, Northwest, Washington, District of Columbia, DC

49 CFR 543.6 - Petition: Specific content requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 6 2010-10-01 2010-10-01 false Petition: Specific content requirements. 543.6...; (4) The reasons for the petitioner's belief that the antitheft device will be effective in reducing... petitioner and form a basis for that belief; (5) The reasons for the petitioner's belief that the agency...

49 CFR 543.6 - Petition: Specific content requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 6 2014-10-01 2014-10-01 false Petition: Specific content requirements. 543.6...; (4) The reasons for the petitioner's belief that the antitheft device will be effective in reducing... petitioner and form a basis for that belief; (5) The reasons for the petitioner's belief that the agency...

49 CFR 543.6 - Petition: Specific content requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 6 2011-10-01 2011-10-01 false Petition: Specific content requirements. 543.6...; (4) The reasons for the petitioner's belief that the antitheft device will be effective in reducing... petitioner and form a basis for that belief; (5) The reasons for the petitioner's belief that the agency...

49 CFR 543.6 - Petition: Specific content requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 6 2012-10-01 2012-10-01 false Petition: Specific content requirements. 543.6...; (4) The reasons for the petitioner's belief that the antitheft device will be effective in reducing... petitioner and form a basis for that belief; (5) The reasons for the petitioner's belief that the agency...

49 CFR 543.6 - Petition: Specific content requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 6 2013-10-01 2013-10-01 false Petition: Specific content requirements. 543.6...; (4) The reasons for the petitioner's belief that the antitheft device will be effective in reducing... petitioner and form a basis for that belief; (5) The reasons for the petitioner's belief that the agency...

Alexander Graham Bell: Teacher of the Deaf.

ERIC Educational Resources Information Center

Bruce, Robert V.

The lecture on Alexander Graham Bell by Dr. Robert V. Bruce, the author of a biography of Bell, focuses on Bell's association with the Clarke School for the Deaf in Massachusetts. Noted are Bell's employment by the school at 25 years of age and the preceding period during which Bell taught elocution at a boys' school in Scotland and used his…

25 CFR 543.14 - What are the minimum internal control standards for patron deposit accounts and cashless systems?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 2 2014-04-01 2014-04-01 false What are the minimum internal control standards for patron deposit accounts and cashless systems? 543.14 Section 543.14 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.14 What are the minimum internal control...

25 CFR 543.12 - What are the minimum internal control standards for gaming promotions and player tracking systems?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false What are the minimum internal control standards for gaming promotions and player tracking systems? 543.12 Section 543.12 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.12 What are the minimum internal contro...

25 CFR 543.14 - What are the minimum internal control standards for patron deposit accounts and cashless systems?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false What are the minimum internal control standards for patron deposit accounts and cashless systems? 543.14 Section 543.14 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.14 What are the minimum internal control...

25 CFR 543.12 - What are the minimum internal control standards for gaming promotions and player tracking systems?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 2 2014-04-01 2014-04-01 false What are the minimum internal control standards for gaming promotions and player tracking systems? 543.12 Section 543.12 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.12 What are the minimum internal contro...

Simultaneous Production of Anabaenopeptins and Namalides by the Cyanobacterium Nostoc sp. CENA543.

PubMed

Shishido, Tânia K; Jokela, Jouni; Fewer, David P; Wahlsten, Matti; Fiore, Marli F; Sivonen, Kaarina

2017-11-17

Anabaenopeptins are a diverse group of cyclic peptides, which contain an unusual ureido linkage. Namalides are shorter structural homologues of anabaenopeptins, which also contain an ureido linkage. The biosynthetic origins of namalides are unknown despite a strong resemblance to anabaenopeptins. Here, we show the cyanobacterium Nostoc sp. CENA543 strain producing new (nostamide B-E (2, 4, 5, and 6)) and known variants of anabaenopeptins (schizopeptin 791 (1) and anabaenopeptin 807 (3)). Surprisingly, Nostoc sp. CENA543 also produced namalide B (8) and the new namalides D (7), E (9), and F (10) in similar amounts to anabaenopeptins. Analysis of the complete Nostoc sp. CENA543 genome sequence indicates that both anabaenopeptins and namalides are produced by the same biosynthetic pathway through module skipping during biosynthesis. This unique process involves the skipping of two modules present in different nonribosomal peptide synthetases during the namalide biosynthesis. This skipping is an efficient mechanism since both anabaenopeptins and namalides are synthesized in similar amounts by Nostoc sp. CENA543. Consequently, gene skipping may be used to increase and possibly broaden the chemical diversity of related peptides produced by a single biosynthetic gene cluster. Genome mining demonstrated that the anabaenopeptin gene clusters are widespread in cyanobacteria and can also be found in tectomicrobia bacteria.

Alexander Meiklejohn in Search of Freedom and Dignity.

ERIC Educational Resources Information Center

Johnson, Tony W.

1982-01-01

Assesses the contributions of the philosopher/educator Alexander Meiklejohn. Discusses the influences of Jean-Jacques Rousseau, Immanuel Kant, and the U.S. Constitution on Meiklejohn's educational theories, which stressed that human freedom and dignity can be enhanced by rigorous examination of U.S. Supreme Court decisions and the meaning of…

Alexander von Humboldt and the Origins of Landscape Archaeology.

ERIC Educational Resources Information Center

Mathewson, Kent

1986-01-01

Reviews the life, theories, and influence of Alexander von Humboldt, the early nineteenth century founder of modern geography. Maintains that Humboldt's novel approaches to the study of landscape antiquities have value for contemporary students in cultural and historical geography. (JDH)

31 CFR 543.504 - Payments and transfers to blocked accounts in U.S. financial institutions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... accounts in U.S. financial institutions. 543.504 Section 543.504 Money and Finance: Treasury Regulations....504 Payments and transfers to blocked accounts in U.S. financial institutions. Any payment of funds or....201(a) has any interest that comes within the possession or control of a U.S. financial institution...

The Century-Old Wisdom of Alexander Graham Bell.

ERIC Educational Resources Information Center

Cornett, Orin

1990-01-01

This article reflects on Alexander Graham Bell's 1888 testimony before the Royal Commission of the United Kingdom on the Condition of the Deaf and Dumb, Etc. Excerpts are grouped by reference to (1) language education for the hearing impaired; (2) speechreading; (3) methods of teaching; (4) speech; and (5) sign language. (Author/PB)

Journalism and the Educational Views of Alexander Meiklejohn.

ERIC Educational Resources Information Center

Palmer, Mack R.

Alexander Meiklejohn, who died in 1964 at the age of 92, was a constitutional scholar whose major interest was education. Among Meiklejohn's beliefs were the following: the social good should take precedence over individual achievement; the liberal arts college is the institution best suited to carry out an affirmative reading of the First…

1. Historic American Buildings Survey J. Alexander, Photographer April 1969 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey J. Alexander, Photographer April 1969 3034 P STREET (right) AND ADJOINING ROWHOUSES, LOOKING EAST - Smith-Morton Row House, 3034 P Street Northwest, Washington, District of Columbia, DC

Q & A: Alexander Varshavsky.

PubMed

Varshavsky, Alexander

2003-07-01

Alexander Varshavsky is Smits Professor of Cell Biology at the California Institute of Technology. He moved to Caltech in 1992, after 15 years at the MIT's Department of Biology. He was born and educated in Russia, and was 30 at the time of his emigration to the U.S. in 1977. In Russia, and for a while at MIT, he studied the structure and replication of chromosomes. Over the last 24 years, the work of his laboratory focused on the ubiquitin system and closely related fields. He is a member of the U.S. National Academy of Sciences, and has received the Gairdner Award, the Lasker Award, the General Motors Sloan Prize, the Wolf Prize, the Horwitz Prize, and the Wilson Medal.

28 CFR 543.16 - Other paralegals, clerks, and legal assistants.

Code of Federal Regulations, 2010 CFR

2010-07-01

... INSTITUTIONAL MANAGEMENT LEGAL MATTERS Inmate Legal Activities § 543.16 Other paralegals, clerks, and legal... may require each assistant to fill out and sign a personal history statement and a pledge to abide by...

Randomised controlled trial of Alexander technique lessons, exercise, and massage (ATEAM) for chronic and recurrent back pain: economic evaluation.

PubMed

Hollinghurst, Sandra; Sharp, Debbie; Ballard, Kathleen; Barnett, Jane; Beattie, Angela; Evans, Maggie; Lewith, George; Middleton, Karen; Oxford, Frances; Webley, Fran; Little, Paul

2008-12-11

An economic evaluation of therapeutic massage, exercise, and lessons in the Alexander technique for treating persistent back pain. Cost consequences study and cost effectiveness analysis at 12 month follow-up of a factorial randomised controlled trial. 579 patients with chronic or recurrent low back pain recruited from primary care. Normal care (control), massage, and six or 24 lessons in the Alexander technique. Half of each group were randomised to a prescription for exercise from a doctor plus behavioural counselling from a nurse. Costs to the NHS and to participants. Comparison of costs with Roland-Morris disability score (number of activities impaired by pain), days in pain, and quality adjusted life years (QALYs). Comparison of NHS costs with QALY gain, using incremental cost effectiveness ratios and cost effectiveness acceptability curves. Intervention costs ranged from pound30 for exercise prescription to pound596 for 24 lessons in Alexander technique plus exercise. Cost of health services ranged from pound50 for 24 lessons in Alexander technique to pound124 for exercise. Incremental cost effectiveness analysis of single therapies showed that exercise offered best value ( pound61 per point on disability score, pound9 per additional pain-free day, pound2847 per QALY gain). For two-stage therapy, six lessons in Alexander technique combined with exercise was the best value (additional pound64 per point on disability score, pound43 per additional pain-free day, pound5332 per QALY gain). An exercise prescription and six lessons in Alexander technique alone were both more than 85% likely to be cost effective at values above pound20 000 per QALY, but the Alexander technique performed better than exercise on the full range of outcomes. A combination of six lessons in Alexander technique lessons followed by exercise was the most effective and cost effective option.

What is the perceived impact of Alexander technique lessons on health status, costs and pain management in the real life setting of an English hospital? The results of a mixed methods evaluation of an Alexander technique service for those with chronic back pain.

PubMed

McClean, Stuart; Brilleman, Sam; Wye, Lesley

2015-07-28

Randomised controlled trial evidence indicates that Alexander Technique is clinically and cost effective for chronic back pain. The aim of this mixed methods evaluation was to explore the role and perceived impact of Alexander Technique lessons in the naturalistic setting of an acute hospital Pain Management Clinic in England. To capture changes in health status and resource use amongst service users, 43 service users were administered three widely used questionnaires (Brief Pain Inventory, MYMOP and Client Service Resource Inventory) at three time points: baseline, six weeks and three months after baseline. We also carried out 27 telephone interviews with service users and seven face-to-face interviews with pain clinic staff and Alexander Technique teachers. Quantitative data were analysed using descriptive statistics and qualitative data were analysed thematically. Those taking Alexander Technique lessons reported small improvements in health outcomes, and condition-related costs fell. However, due to the non-randomised, uncontrolled nature of the study design, changes cannot be attributed to the Alexander Technique lessons. Service users stated that their relationship to pain and pain management had changed, especially those who were more committed to practising the techniques regularly. These changes may explain the reported reduction in pain-related service use and the corresponding lower associated costs. Alexander Technique lessons may be used as another approach to pain management. The findings suggests that Alexander Technique lessons can help improve self-efficacy for those who are sufficiently motivated, which in turn may have an impact on service utilisation levels.

Infantile Alexander Disease: Spectrum of GFAP Mutations and Genotype-Phenotype Correlation

PubMed Central

Rodriguez, Diana; Gauthier, Fernande; Bertini, Enrico; Bugiani, Marianna; Brenner, Michael; N'guyen, Sylvie; Goizet, Cyril; Gelot, Antoinette; Surtees, Robert; Pedespan, Jean-Michel; Hernandorena, Xavier; Troncoso, Monica; Uziel, Graziela; Messing, Albee; Ponsot, Gérard; Pham-Dinh, Danielle; Dautigny, André; Boespflug-Tanguy, Odile

2001-01-01

Heterozygous, de novo mutations in the glial fibrillary acidic protein (GFAP) gene have recently been reported in 12 patients affected by neuropathologically proved Alexander disease. We searched for GFAP mutations in a series of patients who had heterogeneous clinical symptoms but were candidates for Alexander disease on the basis of suggestive neuroimaging abnormalities. Missense, heterozygous, de novo GFAP mutations were found in exons 1 or 4 for 14 of the 15 patients analyzed, including patients without macrocephaly. Nine patients carried arginine mutations (four had R79H; four had R239C; and one had R239H) that have been described elsewhere, whereas the other five had one of four novel mutations, of which two affect arginine (2R88C and 1R88S) and two affect nonarginine residues (1L76F and 1N77Y). All mutations were located in the rod domain of GFAP, and there is a correlation between clinical severity and the affected amino acid. These results confirm that GFAP mutations are a reliable molecular marker for the diagnosis of infantile Alexander disease, and they also form a basis for the recommendation of GFAP analysis for prenatal diagnosis to detect potential cases of germinal mosaicism. PMID:11567214

Alexander A Friedmann

NASA Astrophysics Data System (ADS)

Tropp, Eduard A.; Frenkel, Viktor Ya.; Chernin, Artur D.

1993-06-01

Our universe can be described mathematically by a simple model developed in 1922 at Petrograd (St. Petersburg) by Alexander Friedmann (1888-1925). Without the benefit of observational evidence, Friedmann predicted that the whole universe would expand and evolve with time. This astonishing prediction was confirmed seven years later by Edwin Hubble. Its originator, unfortunately didn't live to savor this triumph. This vivid biography of an outstanding scientist sets his life and work against a wide backdrop of the history of cosmological studies and its major players, such as Einstein and others. The book is a window on Friedmann's school and university years, military service, and teaching and research during a seminal period of Soviet history. The authors include unique archival material, such as Friedmann's letters from the Russian Front, as well as contemporary records and reminiscences of colleagues. There is a detailed treatment of his work in theoretical cosmology (1922-1924), set in the context of the organization of Soviet science at the time.

26 CFR 1.543-1 - Personal holding company income.

Code of Federal Regulations, 2014 CFR

2014-04-01

... (other than mineral, oil, or gas royalties or certain copyright royalties). The term royalties (other than mineral, oil, or gas royalties or certain copyright royalties) includes amounts received for the... section 543(a)(7) and subparagraph (10) of this paragraph. For rules relating to mineral, oil, or gas...

40 CFR 415.543 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... economically achievable (BAT). 415.543 Section 415.543 Protection of Environment ENVIRONMENTAL PROTECTION... achievable (BAT). Except as provided in 40 CFR 125.30 through 125.32, any existing point source subject to... (BAT): The limitations on COD, Chromium(T), and Zinc(T) are the same as specified in § 415.542. ...

40 CFR 415.543 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... economically achievable (BAT). 415.543 Section 415.543 Protection of Environment ENVIRONMENTAL PROTECTION... achievable (BAT). Except as provided in 40 CFR 125.30 through 125.32, any existing point source subject to... (BAT): The limitations on COD, Chromium(T), and Zinc(T) are the same as specified in § 415.542. ...

40 CFR 415.543 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... economically achievable (BAT). 415.543 Section 415.543 Protection of Environment ENVIRONMENTAL PROTECTION... achievable (BAT). Except as provided in 40 CFR 125.30 through 125.32, any existing point source subject to... (BAT): The limitations on COD, Chromium(T), and Zinc(T) are the same as specified in § 415.542. ...

12 CFR 543.2 - Application for permission to organize.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Application for permission to organize. 543.2... permission to organize. (a) General. Recommendations by employees of the OTS regarding applications for...), (e), (f) or (g)(2) of this section. (2) Approval of an application for permission to organize an...

The deglacial history of NW Alexander Island, Antarctica, from surface exposure dating

NASA Astrophysics Data System (ADS)

Johnson, Joanne S.; Everest, Jeremy D.; Leat, Philip T.; Golledge, Nicholas R.; Rood, Dylan H.; Stuart, Finlay M.

2012-03-01

Recent changes along the margins of the Antarctic Peninsula, such as the collapse of the Wilkins Ice Shelf, have highlighted the effects of climatic warming on the Antarctic Peninsula Ice Sheet (APIS). However, such changes must be viewed in a long-term (millennial-scale) context if we are to understand their significance for future stability of the Antarctic ice sheets. To address this, we present nine new cosmogenic 10Be exposure ages from sites on NW Alexander Island and Rothschild Island (adjacent to the Wilkins Ice Shelf) that provide constraints on the timing of thinning of the Alexander Island ice cap since the last glacial maximum. All but one of the 10Be ages are in the range 10.2-21.7 ka, showing a general trend of progressive ice-sheet thinning since at least 22 ka until 10 ka. The data also provide a minimum estimate (490 m) for ice-cap thickness on NW Alexander Island at the last glacial maximum. Cosmogenic 3He ages from a rare occurrence of mantle xenoliths on Rothschild Island yield variable ages up to 46 ka, probably reflecting exhumation by periglacial processes.

The impact of the alexander technique on improving posture and surgical ergonomics during minimally invasive surgery: pilot study.

PubMed

Reddy, Pramod P; Reddy, Trisha P; Roig-Francoli, Jennifer; Cone, Lois; Sivan, Bezalel; DeFoor, W Robert; Gaitonde, Krishnanath; Noh, Paul H

2011-10-01

One of the main ergonomic challenges during surgical procedures is surgeon posture. There have been reports of a high number of work related injuries in laparoscopic surgeons. The Alexander technique is a process of psychophysical reeducation of the body to improve postural balance and coordination, permitting movement with minimal strain and maximum ease. We evaluated the efficacy of the Alexander technique in improving posture and surgical ergonomics during minimally invasive surgery. We performed a prospective cohort study in which subjects served as their own controls. Informed consent was obtained. Before Alexander technique instruction/intervention subjects underwent assessment of postural coordination and basic laparoscopic skills. All subjects were educated about the Alexander technique and underwent post-instruction/intervention assessment of posture and laparoscopic skills. Subjective and objective data obtained before and after instruction/intervention were tabulated and analyzed for statistical significance. All 7 subjects completed the study. Subjects showed improved ergonomics and improved ability to complete FLS™ as well as subjective improvement in overall posture. The Alexander technique training program resulted in a significant improvement in posture. Improved surgical ergonomics, endurance and posture decrease surgical fatigue and the incidence of repetitive stress injuries to laparoscopic surgeons. Further studies of the influence of the Alexander technique on surgical posture, minimally invasive surgery ergonomics and open surgical techniques are warranted to explore and validate the benefits for surgeons. Copyright © 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

miR-543 is up-regulated in gefitinib-resistant non-small cell lung cancer and promotes cell proliferation and invasion via phosphatase and tensin homolog

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bi, Mingjun; Chen, Wei; Yu, Hongmei

MicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level. Here, we identified that miR-543 is up-regulated in gefitinib-resistant non-small cell lung cancer (NSCLC) patients comparing gefitinib-sensitive ones. It promotes NSCLC cell proliferation by negatively regulates its target gene PTEN. In NSCLC cell lines, CCK-8 proliferation assay indicated that the cell proliferation is promoted by miR-543 mimics. Transwell assay showed that miR-543 mimics promotes the invasion and migration of NSCLC cells. Luciferase assays confirmed that miR-543 directly binds to the 3'untranslated region of PTEN, and western blotting showed thatmore » miR-543 suppresses the expression of PTEN at the protein level. This study indicates that miR-543 promotes proliferation and invasion of NSCLC cell lines by PTEN. The miR-543 may represent a potential therapeutic target for gefitinib-resistant NSCLC intervention. - Highlights: • miR-543 is highly expressed in gefitinib-resistant NSCLC. • miR-543 promotes the proliferation and invasion of NSCLC cells. • miR-543 inhibitors inhibits the proliferation and invasion of NSCLC cells. • miR-543 targets 3′ UTR of PTEN in NSCLC cells. • miR-543 inhibits PTEN in NSCLC cells.« less

How Alexander von Humboldt's life story can inspire innovative soil research in developing countries

NASA Astrophysics Data System (ADS)

Bouma, Johan

2017-09-01

The pioneering vision of Alexander von Humboldt of science and society of the early 1800s is still highly relevant today. His open mind and urge to make many measurements characterizing the interconnected web of life are crucial ingredients as we now face the worldwide challenge of the UN Sustainable Development Goals. Case studies in the Philippines, Vietnam, Kenya, Niger, and Costa Rica demonstrate, in Alexander's spirit, interaction with stakeholders and attention to unique local conditions, applying modern measurement and modeling methods and allowing inter- and transdisciplinary research approaches. But relations between science and society are increasingly problematic, partly as a result of the information revolution and post-truth, fact-free thinking. Overly regulated and financially restricted scientific communities in so-called developed countries may stifle intellectual creativity. Researchers in developing countries are urged to leapfrog these problems in the spirit of Alexander von Humboldt as they further develop their scientific communities. Six suggestions to the science community are made with particular attention to soil science. (The Humboldt lecture, presented by the 2017 recipient of the Alexander von Humboldt lecture, Johan Bouma, can be accessed at http://client.cntv.at/egu2017/ml1.)

Patients' views of receiving lessons in the Alexander technique and an exercise prescription for managing back pain in the ATEAM trial.

PubMed

Yardley, Lucy; Dennison, Laura; Coker, Rebecca; Webley, Frances; Middleton, Karen; Barnett, Jane; Beattie, Angela; Evans, Maggie; Smith, Peter; Little, Paul

2010-04-01

Lessons in the Alexander Technique and exercise prescription proved effective for managing low back pain in primary care in a clinical trial. To understand trial participants' expectations and experiences of the Alexander Technique and exercise prescription. A questionnaire assessing attitudes to the intervention, based on the Theory of Planned Behaviour, was completed at baseline and 3-month follow-up by 183 people assigned to lessons in the Alexander Technique and 176 people assigned to exercise prescription. Semi-structured interviews to assess the beliefs contributing to attitudes to the intervention were carried out at baseline with14 people assigned to the lessons in the Alexander Technique and 16 to exercise prescription, and at follow-up with 15 members of the baseline sample. Questionnaire responses indicated that attitudes to both interventions were positive at baseline but became more positive at follow-up only in those assigned to lessons in the Alexander Technique. Thematic analysis of the interviews suggested that at follow-up many patients who had learned the Alexander Technique felt they could manage back pain better. Whereas many obstacles to exercising were reported, few barriers to learning the Alexander Technique were described, since it 'made sense', could be practiced while carrying out everyday activities or relaxing, and the teachers provided personal advice and support. Using the Alexander Technique was viewed as effective by most patients. Acceptability may have been superior to exercise because of a convincing rationale and social support and a better perceived fit with the patient's particular symptoms and lifestyle.

31 CFR 543.201 - Prohibited transactions involving blocked property.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Specially Designated Nationals and Blocked Persons List (“SDN List”) with the identifier “[COTED].” The SDN...://www.treasury.gov/sdn. Additional information pertaining to the SDN List can be found in appendix A to this chapter. See § 543.411 concerning entities that may not be listed on the SDN List but whose...

31 CFR 543.201 - Prohibited transactions involving blocked property.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Specially Designated Nationals and Blocked Persons List (“SDN List”) with the identifier “[COTED].” The SDN...://www.treasury.gov/sdn. Additional information pertaining to the SDN List can be found in appendix A to this chapter. See § 543.411 concerning entities that may not be listed on the SDN List but whose...

31 CFR 543.201 - Prohibited transactions involving blocked property.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Specially Designated Nationals and Blocked Persons List (“SDN List”) with the identifier “[COTED].” The SDN...://www.treasury.gov/sdn. Additional information pertaining to the SDN List can be found in appendix A to this chapter. See § 543.411 concerning entities that may not be listed on the SDN List but whose...

31 CFR 543.201 - Prohibited transactions involving blocked property.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Specially Designated Nationals and Blocked Persons List (“SDN List”) with the identifier “[COTED].” The SDN...://www.treasury.gov/sdn. Additional information pertaining to the SDN List can be found in appendix A to this chapter. See § 543.411 concerning entities that may not be listed on the SDN List but whose...

Dr Alexander Graham Bell--audiologist and speech therapist.

PubMed

Chakravorty, R C

1976-09-01

Alexander Graham Bell is best known for his role in the invention of the telephone. However, he had a lifelong involvement in speech therapy and audiology besides many other medical investigations. He was also awarded an honorary MD degree from Heidelberg University. In this, the 100th anniversary of his invention of the telephone, his life and some of his medical interests are briefly reviewed.

40 CFR 141.543 - How is the disinfection benchmark calculated?

Code of Federal Regulations, 2010 CFR

2010-07-01

...) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration and Disinfection-Systems Serving Fewer Than 10,000 People Disinfection Benchmark § 141.543 How is the disinfection... 40 Protection of Environment 22 2010-07-01 2010-07-01 false How is the disinfection benchmark...

31 CFR 543.201 - Prohibited transactions involving blocked property.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Persons List (“SDN List”) (which is accessible via the Office of Foreign Assets Control's Web site... “[COTED].” See § 543.411 concerning entities that may not be listed on the SDN list but whose property and... pursuant to this part also are published on the SDN List, published in the Federal Register and...

Evidence for the effectiveness of Alexander Technique lessons in medical and health-related conditions: a systematic review.

PubMed

Woodman, J P; Moore, N R

2012-01-01

Complementary medicine and alternative approaches to chronic and intractable health conditions are increasingly being used, and require critical evaluation. The aim of this review was to systematically evaluate available evidence for the effectiveness and safety of instruction in the Alexander Technique in health-related conditions. PUBMED, EMBASE, PSYCHINFO, ISI Web-of-Knowledge, AMED, CINHAL-plus, Cochrane library and Evidence-based Medicine Reviews were searched to July 2011. Inclusion criteria were prospective studies evaluating Alexander Technique instruction (individual lessons or group delivery) as an intervention for any medical indication/health-related condition. Studies were categorised and data extracted on study population, randomisation method, nature of intervention and control, practitioner characteristics, validity and reliability of outcome measures, completeness of follow-up and statistical analyses.   Of 271 publications identified, 18 were selected: three randomised, controlled trials (RCTs), two controlled non-randomised studies, eight non-controlled studies, four qualitative analyses and one health economic analysis. One well-designed, well-conducted RCT demonstrated that, compared with usual GP care, Alexander Technique lessons led to significant long-term reductions in back pain and incapacity caused by chronic back pain. The results were broadly supported by a smaller, earlier RCT in chronic back pain. The third RCT, a small, well-designed, well-conducted study in individuals with Parkinson's disease, showed a sustained increased ability to carry out everyday activities following Alexander lessons, compared with usual care. The 15 non-RCT studies are also reviewed. Strong evidence exists for the effectiveness of Alexander Technique lessons for chronic back pain and moderate evidence in Parkinson's-associated disability. Preliminary evidence suggests that Alexander Technique lessons may lead to improvements in balance skills in the

Randomised controlled trial of Alexander technique lessons, exercise, and massage (ATEAM) for chronic and recurrent back pain.

PubMed

Little, Paul; Lewith, George; Webley, Fran; Evans, Maggie; Beattie, Angela; Middleton, Karen; Barnett, Jane; Ballard, Kathleen; Oxford, Frances; Smith, Peter; Yardley, Lucy; Hollinghurst, Sandra; Sharp, Debbie

2008-08-19

To determine the effectiveness of lessons in the Alexander technique, massage therapy, and advice from a doctor to take exercise (exercise prescription) along with nurse delivered behavioural counselling for patients with chronic or recurrent back pain. Factorial randomised trial. 64 general practices in England. 579 patients with chronic or recurrent low back pain; 144 were randomised to normal care, 147 to massage, 144 to six Alexander technique lessons, and 144 to 24 Alexander technique lessons; half of each of these groups were randomised to exercise prescription. Normal care (control), six sessions of massage, six or 24 lessons on the Alexander technique, and prescription for exercise from a doctor with nurse delivered behavioural counselling. Roland Morris disability score (number of activities impaired by pain) and number of days in pain. Exercise and lessons in the Alexander technique, but not massage, remained effective at one year (compared with control Roland disability score 8.1: massage -0.58, 95% confidence interval -1.94 to 0.77, six lessons -1.40, -2.77 to -0.03, 24 lessons -3.4, -4.76 to -2.03, and exercise -1.29, -2.25 to -0.34). Exercise after six lessons achieved 72% of the effect of 24 lessons alone (Roland disability score -2.98 and -4.14, respectively). Number of days with back pain in the past four weeks was lower after lessons (compared with control median 21 days: 24 lessons -18, six lessons -10, massage -7) and quality of life improved significantly. No significant harms were reported. One to one lessons in the Alexander technique from registered teachers have long term benefits for patients with chronic back pain. Six lessons followed by exercise prescription were nearly as effective as 24 lessons. National Research Register N0028108728.

Randomised controlled trial of Alexander technique lessons, exercise, and massage (ATEAM) for chronic and recurrent back pain.

PubMed

Little, Paul; Lewith, George; Webley, Fran; Evans, Maggie; Beattie, Angela; Middleton, Karen; Barnett, Jane; Ballard, Kathleen; Oxford, Frances; Smith, Peter; Yardley, Lucy; Hollinghurst, Sandra; Sharp, Debbie

2008-12-01

To determine the effectiveness of lessons in the Alexander technique, massage therapy, and advice from a doctor to take exercise (exercise prescription) along with nurse delivered behavioural counselling for patients with chronic or recurrent back pain. Factorial randomised trial. Setting 64 general practices in England. 579 patients with chronic or recurrent low back pain; 144 were randomised to normal care, 147 to massage, 144 to six Alexander technique lessons, and 144 to 24 Alexander technique lessons; half of each of these groups were randomised to exercise prescription. Normal care (control), six sessions of massage, six or 24 lessons on the Alexander technique, and prescription for exercise from a doctor with nurse delivered behavioural counselling. Roland Morris disability score (number of activities impaired by pain) and number of days in pain. Exercise and lessons in the Alexander technique, but not massage, remained effective at one year (compared with control Roland disability score 8.1: massage -0.58, 95% confidence interval -1.94 to 0.77, six lessons -1.40, -2.77 to -0.03, 24 lessons -3.4, -4.76 to -2.03, and exercise -1.29, -2.25 to -0.34). Exercise after six lessons achieved 72% of the effect of 24 lessons alone (Roland disability score -2.98 and -4.14, respectively). Number of days with back pain in the past four weeks were lower after lessons (compared with control median 21 days: 24 lessons -18, six lessons -10, massage -7) and quality of life improved significantly. No significant harms were reported. One to one lessons in the Alexander technique from registered teachers have long term benefits for patients with chronic back pain. Six lessons followed by exercise prescription were nearly as effective as 24 lessons.

Teaching Nuclear Radiation and the Poisoning of Alexander Litvinenko

ERIC Educational Resources Information Center

David R. Lapp

2008-01-01

The recent international story about the death of the former KGB agent Alexander Litvinenko has more than just a few wondering about radiation poisoning and the sinister sounding polonium-210. I was preparing to begin a nuclear radiation unit the Monday after Thanksgiving 2006. As it turned out, Litvinenko died Thanksgiving Day after a short and…

Alexander Samokutyaev conducts BTKh-14/Bioemulsiya (Bioemulsion) Experiment

NASA Image and Video Library

2011-05-05

ISS027-E-022454 (5 May 2011) --- Russian cosmonaut Alexander Samokutyaev, Expedition 27 flight engineer, uses a glovebox to service the Russian Bioemulsion science payload in the Poisk Mini-Research Module 2 (MRM2) of the International Space Station. The Bioemulsion experiment is attempting to develop faster technologies for obtaining microorganism biomass and biologically active substance biomass for creating highly efficient environmentally pure bacteria, enzymes, and medicinal/pharmaceutical preparations.

Teachers' professional development needs and current practices at the Alexander Science Center School

NASA Astrophysics Data System (ADS)

Gargus, Gerald Vincent

This investigation represents an in-depth understanding of teacher professional development at the Alexander Science Center School, a dependent charter museum school established through a partnership between the California Science Center and Los Angeles Unified School District. Three methods of data collection were used. A survey was distributed and collected from the school's teachers, resulting in a prioritized list of teacher professional development needs, as well as a summary of teachers' opinions about the school's existing professional development program. In addition, six key stakeholders in the school's professional development program were interviewed for the study. Finally, documents related to the school's professional development program were analyzed. Data collected from the interviews and documents were used to develop an understand various components of the Alexander Science Center School's professional development program. Teachers identified seven areas that had a high-priority for future professional development including developing skills far working with below-grade-level students, improving the analytical skills of student in mathematics, working with English Language Learners, improving students' overall reading ability levels, developing teachers' content-area knowledge for science, integrating science across the curriculum, and incorporating hands-on activity-based learning strategies to teach science. Professional development needs identified by Alexander Science Center School teachers were categorized based on their focus on content knowledge, pedagogical content knowledge, or curricular knowledge. Analysis of data collected through interviews and documents revealed that the Alexander Science Center School's professional development program consisted of six venues for providing professional development for teachers including weekly "banked time" sessions taking place within the standard school day, grade-level meetings, teacher support

New Models at Lasell: Q&A with President Michael Alexander

ERIC Educational Resources Information Center

Harney, John O.

2018-01-01

The "New England Journal of Higher Education" ("NEJHE") Executive Editor John O. Harney had the chance to catch up with Lasell College President Michael Alexander about the small Newton, Massachusetts, college's plans to challenge the higher education business model. The interview is presented in this article.

Alexander Bain's CUE in the Post-Modern World: Unity Revisited.

ERIC Educational Resources Information Center

Dryden, Phyllis

In 1866, Alexander Bain proposed that by evaluating unity, coherence, and emphasis (which he brought together under the acronym "CUE"), students could judge the effectiveness of their written paragraphs. One hundred twenty-five years later, the proposition is still central to composition instruction. A review of modern writing textbooks…

40 CFR 141.543 - How is the disinfection benchmark calculated?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 24 2012-07-01 2012-07-01 false How is the disinfection benchmark... Disinfection-Systems Serving Fewer Than 10,000 People Disinfection Benchmark § 141.543 How is the disinfection benchmark calculated? If your system is making a significant change to its disinfection practice, it must...

40 CFR 141.543 - How is the disinfection benchmark calculated?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 23 2014-07-01 2014-07-01 false How is the disinfection benchmark... Disinfection-Systems Serving Fewer Than 10,000 People Disinfection Benchmark § 141.543 How is the disinfection benchmark calculated? If your system is making a significant change to its disinfection practice, it must...

40 CFR 141.543 - How is the disinfection benchmark calculated?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 24 2013-07-01 2013-07-01 false How is the disinfection benchmark... Disinfection-Systems Serving Fewer Than 10,000 People Disinfection Benchmark § 141.543 How is the disinfection benchmark calculated? If your system is making a significant change to its disinfection practice, it must...

40 CFR 141.543 - How is the disinfection benchmark calculated?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 23 2011-07-01 2011-07-01 false How is the disinfection benchmark... Disinfection-Systems Serving Fewer Than 10,000 People Disinfection Benchmark § 141.543 How is the disinfection benchmark calculated? If your system is making a significant change to its disinfection practice, it must...

6 CFR 5.43 - Service of subpoenas, court orders, and other demands or requests for official information or...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Service of subpoenas, court orders, and other demands or requests for official information or action. 5.43 Section 5.43 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY DISCLOSURE OF RECORDS AND INFORMATION Disclosure of Information...

Laser diode and pumped Cr:Yag passively Q-switched yellow-green laser at 543 nm

NASA Astrophysics Data System (ADS)

Yao, Y.; Ling, Zhao; Li, B.; Qu, D. P.; Zhou, K.; Zhang, Y. B.; Zhao, Y.; Zheng, Q.

2013-03-01

Efficient and compact yellow green pulsed laser output at 543 nm is generated by frequency doubling of a passively Q-switched end diode-pumped Nd:YVO4 laser at 1086 nm under the condition of sup-pressing the higher gain transition near 1064 nm. With 15 W of diode pump power and the frequency doubling crystal LBO, as high as 1.58 W output power at 543 nm is achieved. The optical to optical conversion efficiency from the corresponding Q-switched fundamental output to the yellow green output is 49%. The peak power of the Q-switched yellow green pulse laser is up to 30 kW with 5 ns pulse duration. The output power stability over 8 hours is better than 2.56% at the maximum output power. To the best of our knowledge, this is the highest watt-level laser at 543 nm generated by frequency doubling of a passively Q-switched end diode pumped Nd:YVO4 laser at 1086 nm.

Alexander Kapp--The First Known User of the Andragogy Concept

ERIC Educational Resources Information Center

Loeng, Svein

2017-01-01

The German gymnasium teacher Alexander Kapp (1800-1869) was to all appearances the first one to use the "andragogy concept" as a term for "adult learning." In 1833 he published the book "Platon's Erziehungslehre, als Pädagogik für die Einzelnen und als Staatspädagogik. Oder dessen praktische Philosophie." This book…

12 CFR 543.9 - Application for conversion to Federal mutual charter.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Application for conversion to Federal mutual... FEDERAL MUTUAL SAVINGS ASSOCIATIONS-INCORPORATION, ORGANIZATION, AND CONVERSION Conversion § 543.9 Application for conversion to Federal mutual charter. (a)(1) Filing. Any depository institution that proposes...

12 CFR 543.9 - Application for conversion to Federal mutual charter.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Application for conversion to Federal mutual... FEDERAL MUTUAL SAVINGS ASSOCIATIONS-INCORPORATION, ORGANIZATION, AND CONVERSION Conversion § 543.9 Application for conversion to Federal mutual charter. (a)(1) Filing. Any depository institution that proposes...

Origin of Silurian reefs in the Alexander Terrane of southeastern Alaska

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soja, C.M.

1991-04-01

Lower to Upper Silurian (upper Llandovery-Ludlow) limestones belonging to the Heceta Formation record several episodes of reef growth in the Alexander terrane of southeastern Alaska. As the oldest carbonates of wide-spread distribution in the region, the Heceta limestones represent the earliest development of a shallow-marine platform within the Alexander arc and the oldest foundation for reef evolution. These deposits provide important insights into the dynamic processes, styles, and bathymetry associated with reef growth in tectonically active oceanic islands. Massive stromatoporoids, corals, and red algae are preserved in fragmental rudstones and represent a fringing reef that formed at the seaward edgemore » of the incipient marine shelf. Accessory constituents in this reef include crinoids and the cyanobacterium Girvanella. Small biostromes were constructed by ramose corals and stromatoporoids on oncolitic substrates in backreef or lagoonal environments. These buildups were associated with low-diversity assemblages of brachiopods and with gastropods, amphiporids, calcareous algae and cyanobacteria. Microbial boundstones reflect the widespread encrustation of cyanobacteria and calcified microproblematica on shelly debris as stromatolitic mats that resulted in the development of a stromatactoid-bearing mud mound and a barrier reef complex. Epiphytaceans, other microbes, and aphrosalpingid sponges were the primary frame-builders of the barrier reefs. These buildups attained significant relief at the shelf margin and shed detritus as slumped blocks and debris flows into deep-water sites along the slope. The similarity of these stromatolitic-aphrosalpingid reefs to those from Siluro-Devonian strata of autochthonous southwestern Alaska suggests paleobiogeographic ties of the Alexander terrane to cratonal North America during the Silurian.« less

Teachers of the Alexander Technique in the UK and the people who take their lessons: A national cross-sectional survey.

PubMed

Eldred, J; Hopton, A; Donnison, E; Woodman, J; MacPherson, H

2015-06-01

Given the rising profile of the Alexander Technique in the UK, there is a need for a comprehensive description of its teachers and of those who currently take lessons. In a national survey of Alexander teachers, we set out to address this information gap. A cross-sectional survey of 871 UK members of three main Alexander Technique teachers' professional associations was conducted. A questionnaire requested information about their professional background, teaching practice and methods, and about the people who attend lessons and their reasons for seeking help. With an overall response rate of 61%, 534 teachers responded; 74% were female with median age of 58 years, 60% had a higher education qualification, and 95% were self-employed, many with additional non-Alexander paid employment. The majority (87%) offered lessons on their own premises or in a privately rented room, and 19% provided home visits; both individual and group lessons were provided. People who took lessons were predominantly female (66%) with a median age of 48 years, and 91% paid for their lessons privately. Nearly two-thirds (62%) began lessons for reasons related to musculoskeletal conditions, including back symptoms, posture, neck pain, and shoulder pain. Other reasons were general (18%, including well-being), performance-related (10%, including voice-, music-, and sport-related), psychological (5%) and neurological (3%). We estimate that Alexander teachers in the UK provide approximately 400,000 lessons per year. This study provides an overview of Alexander Technique teaching in the UK today and data that may be useful when planning future research. Copyright © 2015 Elsevier Ltd. All rights reserved.

64. Photocopy of Buoy Derrick Arrangement, WAGL 543 and WAGL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

64. Photocopy of Buoy Derrick Arrangement, WAGL 543 and WAGL 542. Puget Sound Naval Shipyard, Bremerton, Washington, Coast Guard Headquarters Drawing No. 540-WAGL-1701-20, dated April 1948. Original drawing property of the U.S. Coast Guard. - U.S. Coast Guard Cutter WHITE HEATH, USGS Integrated Support Command Boston, 427 Commercial Street, Boston, Suffolk County, MA

31 CFR 543.407 - Payments from blocked accounts to satisfy obligations prohibited.

Code of Federal Regulations, 2012 CFR

2012-07-01

... to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CôTE D... obligations prohibited. Pursuant to § 543.201, no debits may be made to a blocked account to pay obligations...

31 CFR 543.407 - Payments from blocked accounts to satisfy obligations prohibited.

Code of Federal Regulations, 2011 CFR

2011-07-01

... to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CôTE D... obligations prohibited. Pursuant to § 543.201, no debits may be made to a blocked account to pay obligations...

Participating in and delivering the ATEAM trial (Alexander technique lessons, exercise, and massage) interventions for chronic back pain: A qualitative study of professional perspectives.

PubMed

Beattie, Angela; Shaw, Alison; Yardley, Lucy; Little, Paul; Sharp, Debbie

2010-01-01

To outline professionals' experiences of participation, perceived benefits and acceptability of the interventions delivered in the ATEAM trial (Alexander technique lessons, exercise, and massage), for patients with chronic or recurrent back pain. Qualitative study using in-depth interviews was conducted with a purposeful sample of twenty professionals (general practitioners (GPs), nurses, Alexander technique teachers, and massage therapists). Data were recorded, transcribed, and analysed thematically using the constant comparison method. Evidence of effectiveness GPs wanted an evidence base for the interventions, whilst nurses, Alexander technique teachers and massage therapists perceived patient reports of benefit as evidence. Professionals' perception of the acceptability of the intervention: professional perspectives differed, with GPs and nurses viewing the structured nature of exercise prescription and Alexander technique lessons as more beneficial and acceptable than massage in alleviating patients' back pain. Economic cost: the cost to patients pursuing Alexander technique lessons and massage was perceived to be a barrier outside the trial. Inter-professional communication: there was little communication between the professionals groups within the trial. Valuable insights have been gained into the perceived benefits and acceptability of exercise, Alexander technique lessons and massage as interventions for chronic back pain. Lessons in the Alexander technique with or without exercise, was perceived as more beneficial and acceptable than massage by professionals who participated and delivered the ATEAM trial interventions. Copyright 2010 Elsevier Ltd. All rights reserved.

View west of the James and Lucy Alexander gravestone and ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View west of the James and Lucy Alexander gravestone and family plot among other demarcated family plots in the Female Union Band Cemetery. - Mount Zion Cemetery/ Female Union Band Cemetery, Bounded by 27th Street right-of-way N.W. (formerly Lyons Mill Road), Q Street N.W., & Mill Road N.W., Washington, District of Columbia, DC

28 CFR 543.11 - Legal research and preparation of legal documents.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Legal research and preparation of legal... INSTITUTIONAL MANAGEMENT LEGAL MATTERS Inmate Legal Activities § 543.11 Legal research and preparation of legal... program or work assignment), to do legal research and to prepare legal documents. Where practical, the...

28 CFR 543.11 - Legal research and preparation of legal documents.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Legal research and preparation of legal... INSTITUTIONAL MANAGEMENT LEGAL MATTERS Inmate Legal Activities § 543.11 Legal research and preparation of legal... program or work assignment), to do legal research and to prepare legal documents. Where practical, the...

28 CFR 543.11 - Legal research and preparation of legal documents.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Legal research and preparation of legal... INSTITUTIONAL MANAGEMENT LEGAL MATTERS Inmate Legal Activities § 543.11 Legal research and preparation of legal... program or work assignment), to do legal research and to prepare legal documents. Where practical, the...

28 CFR 543.11 - Legal research and preparation of legal documents.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Legal research and preparation of legal... INSTITUTIONAL MANAGEMENT LEGAL MATTERS Inmate Legal Activities § 543.11 Legal research and preparation of legal... program or work assignment), to do legal research and to prepare legal documents. Where practical, the...

28 CFR 543.11 - Legal research and preparation of legal documents.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Legal research and preparation of legal... INSTITUTIONAL MANAGEMENT LEGAL MATTERS Inmate Legal Activities § 543.11 Legal research and preparation of legal... program or work assignment), to do legal research and to prepare legal documents. Where practical, the...

Alexander Williamson and the modernisation of Japan.

PubMed

Davies, Alwyn G

2015-01-01

One hundred and fifty years ago, five students were smuggled out of feudal Japan and came to London to learn Western technology, governance, and economics. They were put into the care of Alexander Williamson, who was Professor of Chemistry at University College London, and when they went back they, and the students who followed them, became the founders of the modern Japanese state. This is the British side of that remarkable story. Williamson's career and chemistry are briefly reviewed, followed by an account of the students' presence in Britain, and then the commemoration of the sesquicentenary of these events.

"In the Footsteps of Alexander the Great" PBS Series. Teacher's Guide.

ERIC Educational Resources Information Center

Corporation for Public Broadcasting, Washington, DC.

This teacher's guide correlates with the Public Broadcasting Service (PBS) television series "In the Footsteps of Alexander the Great" hosted by historian Michael Wood. The four episodes of the series are entitled: "Son of God"; "Lord of Asia"; "Across the Hindu Kush"; and "To the Ends of the…

Science, Education, and Antebellum Reform: The Case of Alexander Dallas Bache.

ERIC Educational Resources Information Center

Slotten, Hugh R.

1991-01-01

Suggest that science and formal education became the primary civilizing forces in the decades preceding the Civil War. Focuses on the work of scientist and educational reformer Alexander Dallas Bache. Concludes that Bache's efforts to promote unified public schools, scientific and technical education, and moral training inspired later Progressive…

An economic evaluation of Alexander Technique lessons or acupuncture sessions for patients with chronic neck pain: A randomized trial (ATLAS).

PubMed

Essex, Holly; Parrott, Steve; Atkin, Karl; Ballard, Kathleen; Bland, Martin; Eldred, Janet; Hewitt, Catherine; Hopton, Ann; Keding, Ada; Lansdown, Harriet; Richmond, Stewart; Tilbrook, Helen; Torgerson, David; Watt, Ian; Wenham, Aniela; Woodman, Julia; MacPherson, Hugh

2017-01-01

To assess the cost-effectiveness of acupuncture and usual care, and Alexander Technique lessons and usual care, compared with usual GP care alone for chronic neck pain patients. An economic evaluation was undertaken alongside the ATLAS trial, taking both NHS and wider societal viewpoints. Participants were offered up to twelve acupuncture sessions or twenty Alexander lessons (equivalent overall contact time). Costs were in pounds sterling. Effectiveness was measured using the generic EQ-5D to calculate quality adjusted life years (QALYs), as well as using a specific neck pain measure-the Northwick Park Neck Pain Questionnaire (NPQ). In the base case analysis, incremental QALY gains were 0.032 and 0.025 in the acupuncture and Alexander groups, respectively, in comparison to usual GP care, indicating moderate health benefits for both interventions. Incremental costs were £451 for acupuncture and £667 for Alexander, mainly driven by intervention costs. Acupuncture was likely to be cost-effective (ICER = £18,767/QALY bootstrapped 95% CI £4,426 to £74,562) and was robust to most sensitivity analyses. Alexander lessons were not cost-effective at the lower NICE threshold of £20,000/QALY (£25,101/QALY bootstrapped 95% CI -£150,208 to £248,697) but may be at £30,000/QALY, however, there was considerable statistical uncertainty in all tested scenarios. In comparison with usual care, acupuncture is likely to be cost-effective for chronic neck pain, whereas, largely due to higher intervention costs, Alexander lessons are unlikely to be cost-effective. However, there were high levels of missing data and further research is needed to assess the long-term cost-effectiveness of these interventions.

Identification of metapopulation dynamics among Northern Goshawks of the Alexander Archipelago, Alaska, and Coastal British Columbia

USGS Publications Warehouse

Sonsthagen, Sarah A.; McClaren, Erica L.; Doyle, Frank I.; Titus, K.; Sage, George K.; Wilson, Robert E.; Gust, Judy R.; Talbot, Sandra L.

2012-01-01

Northern Goshawks occupying the Alexander Archipelago, Alaska, and coastal British Columbia nest primarily in old-growth and mature forest, which results in spatial heterogeneity in the distribution of individuals across the landscape. We used microsatellite and mitochondrial data to infer genetic structure, gene flow, and fluctuations in population demography through evolutionary time. Patterns in the genetic signatures were used to assess predictions associated with the three population models: panmixia, metapopulation, and isolated populations. Population genetic structure was observed along with asymmetry in gene flow estimates that changed directionality at different temporal scales, consistent with metapopulation model predictions. Therefore, Northern Goshawk assemblages located in the Alexander Archipelago and coastal British Columbia interact through a metapopulation framework, though they may not fit the classic model of a metapopulation. Long-term population sources (coastal mainland British Columbia) and sinks (Revillagigedo and Vancouver islands) were identified. However, there was no trend through evolutionary time in the directionality of dispersal among the remaining assemblages, suggestive of a rescue-effect dynamic. Admiralty, Douglas, and Chichagof island complex appears to be an evolutionarily recent source population in the Alexander Archipelago. In addition, Kupreanof island complex and Kispiox Forest District populations have high dispersal rates to populations in close geographic proximity and potentially serve as local source populations. Metapopulation dynamics occurring in the Alexander Archipelago and coastal British Columbia by Northern Goshawks highlight the importance of both occupied and unoccupied habitats to long-term population persistence of goshawks in this region.

46. Photocopy of photograph (Pentran file), (from Alexander Brown's Peninsula's ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

46. Photocopy of photograph (Pentran file), (from Alexander Brown's Peninsula's Last Street Cars, Daily Press, January 15, 1956) photographer unknown. The first streetcar (with dignitaries) to make the run from Newport News to a new housing development named Hilton Village in September 1918. - Newport News & Old Point Railway & Electric Company, Trolley Barn & Administration Building, 3400 Victoria Boulevard, Hampton, Hampton, VA

25 CFR 543.7 - What are the minimum internal control standards for bingo?

Code of Federal Regulations, 2010 CFR

2010-04-01

... information technology security standards can be found in § 543.16 of this part.) (2) The game software... applicable voucher system, player interface or other transaction history records to verify the validity of...

Interview with Alexander Cohen.

PubMed

Cohen, Alexander Ander

2017-05-01

Ander Cohen speaks to Adam Price-Evans, Commissioning Editor of Future Cardiology: Alexander (Ander) Cohen MBBS (Hons), MSc, MD, FRACP is a vascular physician and epidemiologist at Guy's and St Thomas' Hospital, King's College (London, UK). He graduated with honors in medicine and honors in surgery from the University of Melbourne, Australia, and became a fellow of the Royal Australasian College of Physicians in 1990. He was awarded an MSc in Epidemiology from the London School of Hygiene and Tropical Medicine, University of London in 1991 with a thesis on the metabolic syndrome in South-Asian populations. In 1998, he was awarded an MD with a thesis on the epidemiology of venous thromboembolism and thromboprophylaxis. In addition to his clinical work, he is involved in designing, managing and analyzing clinical trials from Phase I to IV. He is the Chairman and a member of many international steering committees for multicenter trials, epidemiological and pharmacoeconomic studies, and was previously the Director of Clinical Research and an Epidemiologist in Thrombosis Research at King's College Hospital.

Clinical Experience in Late Antiquity: Alexander of Tralles and the Therapy of Epilepsy

PubMed Central

Bouras-vallianatos, Petros

2014-01-01

Alexander of Tralles, writing in the late sixth century, combined his wide-ranging practical knowledge with earlier medical theories. This article shows how clinical experience is used in Alexander’s works by concentrating on his therapeutic advice on epilepsy and, in particular, on pharmacology and the group of so-called natural remedies. I argue that clinical testing is used not only for the introduction of new medicines but also as an instrument for checking the therapeutic effect of popular healing practices. On another level, this article discusses Alexander’s role as the author of a medical compendium; it suggests that by marking the cases of clinical testing with a set of recurrent expressions, Alexander leads his audience to reflect on his medical authority and personal contribution. PMID:25045178

[Urology and National Socialism: the fate of Alexander von Lichtenberg 1880-1949].

PubMed

Moll, F H; Krischel, M; Rathert, P; Fangerau, H

2010-09-01

Alexander von Lichtenberg (1880-1949) was one of the famous members of the German Urological Society (DGU) in pre-war Germany. He introduced excretion urography and a special TURP Instrument. In 1928 he was president of the 8th meeting held in the German capital Berlin. His Handbook of Urology, released by Ferdinand Springer publishing house, was a trendsetter in establishing urology as a specialty in Germany and bringing together the whole wisdom of all aspects of urology. He was the founder of the famous Maximilian Nitze Award of the DGU. As a Jew he-like many others-was forced to leave Nazi Germany after 1933. Even in Hungary, his native country, he again had to resist anti-Semitic hostility. Later on he lived in Mexico. Alexander von Lichtenberg has to be remembered with special focus on the exodus of German Jewish scientists during the Nazi time.

An economic evaluation of Alexander Technique lessons or acupuncture sessions for patients with chronic neck pain: A randomized trial (ATLAS)

PubMed Central

Essex, Holly; Parrott, Steve; Atkin, Karl; Ballard, Kathleen; Bland, Martin; Eldred, Janet; Hewitt, Catherine; Hopton, Ann; Keding, Ada; Lansdown, Harriet; Richmond, Stewart; Tilbrook, Helen; Torgerson, David; Watt, Ian; Wenham, Aniela; Woodman, Julia; MacPherson, Hugh

2017-01-01

Objectives To assess the cost-effectiveness of acupuncture and usual care, and Alexander Technique lessons and usual care, compared with usual GP care alone for chronic neck pain patients. Methods An economic evaluation was undertaken alongside the ATLAS trial, taking both NHS and wider societal viewpoints. Participants were offered up to twelve acupuncture sessions or twenty Alexander lessons (equivalent overall contact time). Costs were in pounds sterling. Effectiveness was measured using the generic EQ-5D to calculate quality adjusted life years (QALYs), as well as using a specific neck pain measure–the Northwick Park Neck Pain Questionnaire (NPQ). Results In the base case analysis, incremental QALY gains were 0.032 and 0.025 in the acupuncture and Alexander groups, respectively, in comparison to usual GP care, indicating moderate health benefits for both interventions. Incremental costs were £451 for acupuncture and £667 for Alexander, mainly driven by intervention costs. Acupuncture was likely to be cost-effective (ICER = £18,767/QALY bootstrapped 95% CI £4,426 to £74,562) and was robust to most sensitivity analyses. Alexander lessons were not cost-effective at the lower NICE threshold of £20,000/QALY (£25,101/QALY bootstrapped 95% CI -£150,208 to £248,697) but may be at £30,000/QALY, however, there was considerable statistical uncertainty in all tested scenarios. Conclusions In comparison with usual care, acupuncture is likely to be cost-effective for chronic neck pain, whereas, largely due to higher intervention costs, Alexander lessons are unlikely to be cost-effective. However, there were high levels of missing data and further research is needed to assess the long-term cost-effectiveness of these interventions. PMID:29211741

Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease

PubMed Central

LaPash Daniels, Christine M.; Paffenroth, Elizabeth; Austin, Elizabeth V.; Glebov, Konstantin; Lewis, Diana; Walter, Jochen; Messing, Albee

2015-01-01

Alexander disease is a fatal neurodegenerative disease caused by mutations in the astrocyte intermediate filament glial fibrillary acidic protein (GFAP). The disease is characterized by elevated levels of GFAP and the formation of protein aggregates, known as Rosenthal fibers, within astrocytes. Lithium has previously been shown to decrease protein aggregates by increasing the autophagy pathway for protein degradation. In addition, lithium has also been reported to decrease activation of the transcription factor STAT3, which is a regulator of GFAP transcription and astrogliogenesis. Here we tested whether lithium treatment would decrease levels of GFAP in a mouse model of Alexander disease. Mice with the Gfap-R236H point mutation were fed lithium food pellets for 4 to 8 weeks. Four weeks of treatment with LiCl at 0.5% in food pellets decreased GFAP protein and transcripts in several brain regions, although with mild side effects and some mortality. Extending the duration of treatment to 8 weeks resulted in higher mortality, and again with a decrease in GFAP in the surviving animals. Indicators of autophagy, such as LC3, were not increased, suggesting that lithium may decrease levels of GFAP through other pathways. Lithium reduced the levels of phosphorylated STAT3, suggesting this as one pathway mediating the effects on GFAP. In conclusion, lithium has the potential to decrease GFAP levels in Alexander disease, but with a narrow therapeutic window separating efficacy and toxicity. PMID:26378915

Connect the Book. Always Inventing: A Photobiography of Alexander Graham Bell

ERIC Educational Resources Information Center

Brodie, Carolyn S.

2004-01-01

Cell phones, video phones, voice messaging?one wonders what Alexander Graham Bell would have thought about the many venues today for electronic communication with one another. Bell's March 10, 1876 invention is now 128 years old, but there is no doubt that Bell's "talking machine" changed the world. This article presents a brief review of the…

Patient as teacher.

PubMed

Kwilosz, Donna M

2005-10-01

The author provides some reflections based on her experiences as a member of Becky's treatment team (see Werth, this issue). She briefly highlights some of the areas that were most important in her work with Becky and others with life-limiting illnesses, including information-seeking, social support, maintaining normalcy, depression and decision-making, nausea and vomiting, post-traumatic stress disorder, and the role of psychotherapy. She ends with her reactions to working with Becky and how Becky touched her personally and professionally.

78 FR 53630 - Airworthiness Directives; Alexander Schleicher GmbH & Co. Segelflugzeugbau Sailplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-30

... rod for conformity following Alexander Schleicher Automatischer H[ouml]henruderanschlu[beta] (English... Manual (CAM) 18, Maintenance, Repair, And Alteration, Of Airframes, Powerplants, Propellers, And...--and-- Guidance--Library/rgccab.nsf/0/41df1277f2dc7e0e86257bcf005112bf/ $FILE/CAM--18--1959.pdf...

Alexander von Humboldt and the concept of animal electricity.

PubMed

Kettenmann, H

1997-06-01

More than two hundred years ago, Alexander von Humboldt helped to establish Galvani's view that muscle and nerve tissue are electrically excitable. His 1797 publication was a landmark for establishing the concept of animal electricity. Almost half a century later, von Humboldt became the mentor of the young du Bois-Reymond. With the help of von Humboldt's promotion, du Bois-Reymond demonstrated convincingly that animal tissue has the intrinsic capacity to generate electrical activity, and thus laid the ground for modern electrophysiology.

A Disciplinary Immigrant. Alexander Smith at the University of Chicago, 1894-1911

ERIC Educational Resources Information Center

Cotter, Donald

2008-01-01

The publication in 1906 of Alexander Smith's "Introduction to general inorganic chemistry" inaugurated a decisive change in chemical pedagogy in the US, the effects of which are still evident. The nature and extent of Smith's innovations are described through a comparison of his text to its source material and contemporaries. His…

Geohydrology and water-chemistry of the Alexander Valley, Sonoma County, California

USGS Publications Warehouse

Metzger, Loren F.; Farrar, Christopher D.; Koczot, Kathryn M.; Reichard, Eric G.

2006-01-01

This study of the geohydrology and water chemistry of the Alexander Valley, California, was done to provide an improved scientific basis for addressing emerging water-management issues, including potential increases in water demand and changes in flows in the Russian River. The study tasks included (1) evaluation of existing geohydrological, geophysical, and geochemical data; (2) collection and analysis of new geohydrologic data, including subsurface lithologic data, ground-water levels, and streamflow records; and (3) collection and analysis of new water-chemistry data. The estimated total water use for the Alexander Valley for 1999 was approximately 15,800 acre-feet. About 13,500 acre-feet of this amount was for agricultural use, primarily vineyards, and about 2,300 acre-feet was for municipal/industrial use. Ground water is the main source of water supply for this area. The main sources of ground water in the Alexander Valley are the Quaternary alluvial deposits, the Glen Ellen Formation, and the Sonoma Volcanics. The alluvial units, where sufficiently thick and saturated, comprise the best aquifer in the study area. Average recharge to the Alexander Valley is estimated from a simple, basinwide water budget. On the basis of an estimated annual average of 298,000 acre-feet of precipitation, 160,000 acre-feet of runoff, and 113,000 to 133,000 acre-feet of evapotranspiration, about 5,000 to 25,000 acre-feet per year is available for ground-water recharge. Because this estimate is based on differences between large numbers, there is significant uncertainty in this recharge estimate. Long-term changes in ground-water levels are evident in parts of the study area, but because of the sparse network and lack of data on well construction and lithology, it is uncertain if any significant changes have occurred in the northern part of the study area since 1980. In the southern half of the study area, ground-water levels generally were lower at the end of the 2002 irrigation

Alexander Hamilton: Soldier-Statesmen of the Constitution. A Bicentennial Series No. 16.

ERIC Educational Resources Information Center

Army Center of Military History, Washington, DC.

Alexander Hamilton was among the most intellectually gifted of the Founding Fathers and a brilliant political theorist, but he lacked practical political experience, and his major political contributions occurred only when his specific policies were adopted and carried forward by others with broader vision. This booklet on Hamilton is one in a…

25 CFR 543.7 - What are the minimum internal control standards for bingo?

Code of Federal Regulations, 2011 CFR

2011-04-01

... software upgrades, data storage media replacement, etc.). The information recorded must be used when...., draw objects and back-up draw objects); and (ii) Random number generator software. (Additional information technology security standards can be found in § 543.16 of this part.) (2) The game software...

25 CFR 543.7 - What are the minimum internal control standards for bingo?

Code of Federal Regulations, 2012 CFR

2012-04-01

... software upgrades, data storage media replacement, etc.). The information recorded must be used when...., draw objects and back-up draw objects); and (ii) Random number generator software. (Additional information technology security standards can be found in § 543.16 of this part.) (2) The game software...

Friendly Letters on the Correspondence of Helen Keller, Anne Sullivan, and Alexander Graham Bell.

ERIC Educational Resources Information Center

Blatt, Burton

1985-01-01

Excerpts from the letters between Alexander Graham Bell and Anne Sullivan and Helen Keller are given to illustrate the educational and personal growth of Helen Keller as well as the educational philosophy of Bell regarding the education of the deaf blind. (DB)

Alexander von Humboldt's perceptions of colonial Spanish America.

PubMed

Rebok, Sandra

2009-01-01

This study presents an in-depth analysis of Alexander von Humboldt's descriptions and critical comments on the colonial society of the different regions he visited during his well-known expedition through the Americas (1799-1804). The criticisms of colonialism that he expressed, reflecting his personal convictions, have already been the focal point of many studies, but Humboldt also was able to offer a more differentiated assessment through comparisons of regional and local traditions and developments. This essay focuses on his personal diaries, which offer many interesting comments on colonial societies. These considerations and impressions made during the expedition are of particular scholarly value since they were not subject to censorship of any kind.

The silent mutation MLH1 c.543C>T resulting in aberrant splicing can cause Lynch syndrome: a case report.

PubMed

Yamaguchi, Tatsuro; Wakatsuki, Tomokazu; Kikuchi, Mari; Horiguchi, Shin-Ichiro; Akagi, Kiwamu

2017-06-01

The proband was a 67-year-old man with transverse and sigmoid colon cancer. Microsatellite instability analysis revealed a high frequency of microsatellite instability, and immunohistochemical staining showed the absence of both MLH1 and PMS2 proteins in the sigmoid colon cancer tissue specimens from the patient. DNA sequencing revealed a nucleotide substitution c.543C>T in MLH1, but this variant did not substitute an amino acid. The MLH1 c.543C>T variant was located 3 bases upstream from the end of exon 6 and created a new splice donor site 4 bases upstream from the end of exon 6. Consequently, the last 4 bases of exon 6 were deleted and frameshift occurred. Thus, the MLH1 c.543C>T silent mutation is considered 'pathogenic'. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

The Election of 1800: Alexander Hamilton and the Death of the Federalist Party.

ERIC Educational Resources Information Center

Holbrook-DeFeo, Gary

1993-01-01

Describes the significance of the election of 1800 in the development of political parties in the United States. Contends that Alexander Hamilton's view of the United States Constitution was dangerous for the new nation and led to a permanent split in the Federalist Party. Includes a resource bibliography for teachers wishing to incorporate this…

Alexander of Macedon, the greatest warrior of all times: did he have seizures?

PubMed

Hughes, John R

2004-10-01

Alexander the Great (356-323 BC) was likely "the most incomparable general the world has ever seen." His name is often listed among the famous individuals in history who have had seizures. Examination of his illnesses reveals that in 333 BC he entered Tarsus, hot and exhausted, and plunged himself into the River Cydnus, ice-cold from melting mountain snows. His cramps were so severe that he was rescued half-conscious and ashen white, and quickly developed acute pneumonia. Only one doctor dared give him a medication, known for producing powerful and immediate effects. Immediately after drinking this medicine "he lost his speech and falling into a swoon, he had scarcely any sense or pulse left" (Plutarch, ad 75). His reactions were the direct effect of the medication, and this and only this phrase represents the "evidence" for epilepsy. None of his other illnesses involved seizures. Clearly, Alexander the Great did not have epilepsy and his name should be removed from the list of famous individuals who have had seizures.

All-solid-state continuous-wave frequency doubling Nd:LuVO4/LBO laser with 2.17 W output power at 543 nm

NASA Astrophysics Data System (ADS)

Li, B.; Zhao, L.; Zhang, Y. B.; Zheng, Q.; Zhao, Y.; Yao, Y.

2013-03-01

Efficient and compact green-yellow laser output at 543 nm is generated by intracavity frequency doubling of a CW diode-pumped Nd:LuVO4 laser at 1086 nm under the condition of suppressing the higher gain transition near 1064 nm. With 16 W of diode pump power and the frequency-doubling crystal LBO, as high as 2.17 W of CW output power at 543 nm is achieved, corresponding to an optical-to-optical conversion efficiency of 13.6% and the output power stability over 8 hours is better than 2.86%. To the best of our knowledge, this is the highest watt-level laser at 543 nm generated by intracavity frequency doubling of a diode pumped Nd:LuVO4 laser at 1086 nm.

31 CFR 543.202 - Effect of transfers violating the provisions of this part.

Code of Federal Regulations, 2010 CFR

2010-07-01

... any property or interest in property blocked pursuant to § 543.201(a), is null and void and shall not..., instruction, or license issued pursuant to this part. (d) Transfers of property that otherwise would be null and void or unenforceable by virtue of the provisions of this section shall not be deemed to be null...

Myelin changes in Alexander disease.

PubMed

Gómez-Pinedo, U; Duran-Moreno, M; Sirerol-Piquer, S; Matias-Guiu, J

2017-03-22

Alexander disease (AxD) is a type of leukodystrophy. Its pathological basis, along with myelin loss, is the appearance of Rosenthal bodies, which are cytoplasmic inclusions in astrocytes. Mutations in the gene coding for GFAP have been identified as a genetic basis for AxD. However, the mechanism by which these variants produce the disease is not understood. The most widespread hypothesis is that AxD develops when a gain of function mutation causes an increase in GFAP. However, this mechanism does not explain myelin loss, given that experimental models in which GFAP expression is normal or mutated do not exhibit myelin disorders. This review analyses other possibilities that may explain this alteration, such as epigenetic or inflammatory alterations, presence of NG2 (+) - GFAP (+) cells, or post-translational modifications in GFAP that are unrelated to increased expression. The different hypotheses analysed here may explain the myelin alteration affecting these patients, and multiple mechanisms may coexist. These theories raise the possibility of designing therapies based on these mechanisms. Copyright © 2017 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

Alexander Thomas Augusta--physician, teacher and human rights activist.

PubMed

Butts, Heather M

2005-01-01

Commissioned surgeon of colored volunteers, April 4, 1863, with the rank of Major. Commissioned regimental surgeon on the 7th Regiment of U.S. Colored Troops, October 2, 1863. Brevet Lieutenant Colonel of Volunteers, March 13, 1865, for faithful and meritorious services--mustered out October 13, 1866. So reads the tombstone at Arlington National Cemetery of Alexander Thomas Augusta, the first black surgeon commissioned in the Union Army during the Civil War and the first black officer-rank soldier to be buried at Arlington Cemetery. He was also instrumental in founding the institutions that later became the hospital and medical college of Howard University and the National Medical Association.

The clinical spectrum of late-onset Alexander disease: a systematic literature review.

PubMed

Balbi, Pietro; Salvini, Silvana; Fundarò, Cira; Frazzitta, Giuseppe; Maestri, Roberto; Mosah, Dibo; Uggetti, Carla; Sechi, GianPietro

2010-12-01

Following the discovery of glial fibrillary acidic protein (GFAP) mutations as the causative factor of Alexander disease (AxD), new case reports have recently increased, prompting a more detailed comprehension of the clinical features of the three disease subtypes (infantile, juvenile and adult). While the clinical pattern of the infantile form has been substantially confirmed, the late-onset subtypes (i.e., juvenile and adult), once considered rare manifestations of AxD, have displayed a wider clinical spectrum. Our aim was to evaluate the clinical phenotype of the adult and juvenile forms by reviewing the previously reported cases. Data were collected from previously published reports on 112 subjects affected by neuropathologically or genetically proven adult and juvenile Alexander disease. Although the late-onset forms of AxD show a wide clinical variability, a common pattern emerges from comparing previously reported cases, characterized by pseudo-bulbar signs, ataxia, and spasticity, associated with atrophy of the medulla and upper cervical cord on neuroimaging. Late-onset AxD cases can no longer be considered as rare manifestations of the disease. The clinical pattern usually reflects the topographic localization of the lesions, with adult cases displaying a predominant infratentorial localization of the lesions. Juvenile cases show clinical and radiological features which are intermediate between adult and infantile forms.

31 CFR 543.409 - Credit extended and cards issued by U.S. financial institutions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Credit extended and cards issued by U...'IVOIRE SANCTIONS REGULATIONS Interpretations § 543.409 Credit extended and cards issued by U.S. financial..., charge cards, debit cards, or other credit facilities issued by a U.S. financial institution to a person...

Alexander William Bickerton: New Zealand’s First Astrophysicist?

NASA Astrophysics Data System (ADS)

Gilmore, Gerard F.

Alexander Bickerton (1842-1929) is of interest to the student of New Zealand astronomical history in several ways. He was the first Professor at Canterbury University College, and had a significant effect on the early development of the University; he was a prominent and successful teacher, Ernest Rutherford being his most famous student; he was a social activist in Victorian Christchurch, eventually establishing a small commune; and he was the originator of the stellar collision theory of novae and other astronomical phenomena. This chapter, which is a slightly revised version of Gilmore (Southern Stars, 29, 87-108, 1982), provides a summary of Bickerton's life and theories, and a bibliography for further reading.

The Doors to Home and History: Post-Colonial Identities in Meena Alexander and Bharati Mukherjee.

ERIC Educational Resources Information Center

Dave, Shilpa

1993-01-01

Examines postcolonial inquiry and studies of identity in Asians of Indian descent, focusing on the works of Meena Alexander and Bharati Mukherjee. Their commentaries on India and immigrant cultures are constantly influenced by a history dependent on Western tradition, although both authors resist the stereotypical definitions imposed by the West.…

Recognizing the Presidents: Was Alexander Hamilton President?

PubMed

Roediger, Henry L; DeSoto, K Andrew

2016-05-01

Studies over the past 40 years have shown that Americans can recall about half the U.S. presidents. Do people know the presidents even though they are unable to access them for recall? We investigated this question using the powerful cues of a recognition test. Specifically, we tested the ability of 326 online subjects to recognize U.S. presidents when presented with their full names among various types of lures. The hit rate for presidential recognition was .88, well above the proportion produced in free recall but far from perfect. Presidents Franklin Pierce and Chester Arthur were recognized less than 60% of the time. Interestingly, four nonpresidents were falsely recognized at relatively high rates, and Alexander Hamilton was more frequently identified as president than were several actual presidents. Even on a recognition test, knowledge of American presidents is imperfect and prone to error. The false alarm data support the theory that false fame can arise from contextual familiarity. © The Author(s) 2016.

25 CFR 543.23 - What are the minimum internal control standards for audit and accounting?

Code of Federal Regulations, 2014 CFR

2014-04-01

... supervision, bingo cards, bingo card sales, draw, prize payout; cash and equivalent controls, technologic aids... 25 Indians 2 2014-04-01 2014-04-01 false What are the minimum internal control standards for audit... INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.23 What are the...

25 CFR 543.23 - What are the minimum internal control standards for audit and accounting?

Code of Federal Regulations, 2013 CFR

2013-04-01

... supervision, bingo cards, bingo card sales, draw, prize payout; cash and equivalent controls, technologic aids... 25 Indians 2 2013-04-01 2013-04-01 false What are the minimum internal control standards for audit... INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.23 What are the...

Speciation despite globally overlapping distributions in Penicillium chrysogenum: the population genetics of Alexander Fleming’s lucky fungus

USDA-ARS?s Scientific Manuscript database

Eighty years ago, Alexander Fleming described the antibiotic effects of a fungus that had contaminated his bacterial culture, kick starting the antimicrobial revolution. The fungus was later ascribed to a globally distributed asexual species, Penicillium chrysogenum. Recently, the species has been...

The Alexander N. Charters Library of Resources for Educators of Adults at Syracuse University Library.

ERIC Educational Resources Information Center

Keenan, Terrance

This document describes the contents of the Alexander N. Charters Library of Resources for Educators of Adults at Syracuse University Library. The document begins with a brief history of the development of the library's collections, which occupy 900 feet of shelf space and contain more than 50 groups of personal papers and records of organizations…

Palaeoglaciology of the Alexander Island ice cap, western Antarctic Peninsula, reconstructed from marine geophysical and core data

NASA Astrophysics Data System (ADS)

Graham, Alastair G. C.; Smith, James A.

2012-03-01

The glacial history of the continental shelf northwest of Alexander Island is not well known, due mainly to a lack of targeted marine data on Antarctica's palaeo-ice sheets in their inter-ice-stream areas. Recently it has been argued that the region was ice-free at the Last Glacial Maximum (LGM) and thus a potential site for glacial refugia. In this paper, multibeam swath bathymetry, sub-bottom profiles and sediment cores are used to map the Alexander Island sector of the Antarctic Peninsula margin, in order to reconstruct the shelf's palaeoglaciology. Sea-floor bedforms provide evidence that an independent ice cap persisted on Alexander Island through the LGM and deglaciation. We show that this ice cap drained via two major, previously-undescribed tidewater outlets (Rothschild and Charcot Glaciers) sourced from an ice dome centred over the west of the island and near-shore areas. The glaciers grounded along deep, fjord-like cross-shelf troughs to within at least ˜10-20 km of the shelf edge, and probably reached the shelf break. Only one small outer-shelf zone appears to have remained free of ice throughout an otherwise extensive LGM. During retreat, grounding-line geomorphology indicates periodic stabilisation of Charcot Glacier on the mid-shelf after 13,500 cal yrs BP, while Rothschild Glacier retreated across its mid-shelf by 14,450 cal yrs BP. The timing of these events is in phase with retreat in nearby Marguerite Trough, and we take this as evidence of a common history and forcing with the Antarctic Peninsula Ice Sheet. The fine details of ice flow documented by our new reconstruction highlight the importance of capturing complex ice flow patterns in models (e.g. in inter-stream areas), for understanding how region-specific parts of Antarctica may change in the future. Moreover, the reconstruction shows that glacial refugia, if present, cannot have been extensive on the Alexander Island shelf at the LGM as indicated by previous biological studies; instead

Alexander F. Chamberlain: a life's work.

PubMed

Berkman, Julia M

2005-01-01

This article examines the life and work of Alexander Francis Chamberlain. Though he has received little attention since the early 1900s, the importance of this scholar should not be underestimated. Chamberlain made notable contributions to the body of knowledge in anthropology-a discipline that, at the time, was a combination of anthropological and psychological inquiry. His early work began with investigations into the cultures and languages of two Indian tribes indigenous to Canada and the northern United States and, within a few decades, positioned Chamberlain as the leading scholar in this domain. Beyond his ethnographic insights, Chamberlain queried the development of the child and wrote on the subject of childhood in world folklore. He concerned himself with a scope of worthwhile subjects ranging from linguistics to women's suffrage. No topic was out of range as all forms of human study addressed the need for seeing each group as a contributing force to humanity at large. Chamberlain emphasized that no single racial, ethnic, or religious group should be singled out as inherently superior to another, a belief far ahead of his time. This article is an attempt at drawing a picture of a man whose scholarly achievements and strength of character are captured in the depth and breadth of his writing.

Silurian Gastropoda from the Alexander terrane, southeast Alaska

USGS Publications Warehouse

Rohr, D.M.; Blodgett, R.B.

2008-01-01

Gastropods are described from Ludlow-age strata of the Heceta Limestone on Prince of Wales Island, southeast Alaska. They are part of a diverse megabenthic fauna of the Alexander terrane, an accreted terrane of Siberian or Uralian affinities. Heceta Limestone gastropods with Uralian affinities include Kirkospira glacialis, which closely resembles "Pleurotomaria" lindstromi Oehlert of Chernyshev, 1893, Retispira cf. R. volgulica (Chernyshev, 1893), and Medfracaulus turriformis (Chernyshev, 1893). Medfracaulus and similar morphotypes such as Coelocaulus karlae are unknown from rocks that are unquestionably part of the North American continent (Laurentia) during Late Silurian time. Beraunia is previously known only from the Silurian of Bohemia. Pachystrophia has previously been reported only from western North American terranes (Eastern Klamath, York, and Farewell terranes) and Europe. Bathmopterus Kirk, 1928, is resurrected and is only known from the Silurian of southeast Alaska. Newly described taxa include Hecetastoma gehrelsi n. gen. and n. sp. and Baichtalia tongassensis n. gen. and n. sp. ??2008 The Geological Society of America.

Expedition 8 Crew Interviews: Alexander Y. Kaleri - FE

NASA Technical Reports Server (NTRS)

2003-01-01

Russian cosmonaut Alexander Y. Kaleri, Flight Engineer on Expedition 8 to the International Space Station (ISS), answers interview questions on this video, either himself or with the help of an interpreter. The questions cover: 1) The goal of the expedition; 2) The place in history of Mir; 3) The reaction to the loss of Columbia in Houston; 4) Why the rewards of spaceflight are worth the risks; 5) Why he decided to become a cosmonaut; 6) His memory of Yuri Gagarin's first flight; 7) What happens on a Soyuz capsule during launch and flight; 8) Are Soyuz maneuvers automatic or manual; 8) How the ISS science mission will be advanced during his stay; 9) The responsibilities of a Flight Engineer onboard the ISS; 10) Extravehicular activity (EVA) plans at that time; 11) The Shuttle Return to Flight and his preference for a Shuttle or Soyuz landing; 12) Why the last Soyuz landing was too rough; 13) The most valueable contribution of the ISS program.

Alternative Dispute Resolution : A Viable Method for Settling Government Contract Disputes

DTIC Science & Technology

1993-06-01

S. Rept. 543, 101st Congress, 2d Session. 14. Page, Reba and Lees, Frederick J., "Roles of Participants in Mini-Trial," Public Contract Law Journal...15. Brittin, Alexander J., "Alternative Dispute Resolution in Government Contract Appeals," Public Contract Law Journal. 16. Dauer, "Litigation v...International Law and Economics. Vol. 20, No. 3, 1987. 22. Page, Reba and Lees, Frederick J., "Roles of Participants in Mini-Trial," Public Contract Law Journal

19 CFR 10.543 - Certain apparel goods made from fabric or yarn not available in commercial quantities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... RATE, ETC. United States-Singapore Free Trade Agreement Rules of Origin § 10.543 Certain apparel goods... both of the Parties from fabric or yarn, regardless of origin, designated by the Committee for the... FR 17412), May 28, 2002 (67 FR 36858), and September 5, 2002 (67 FR 56806). Origin Verifications and...

The Alexander Technique and musicians: a systematic review of controlled trials.

PubMed

Klein, Sabine D; Bayard, Claudine; Wolf, Ursula

2014-10-24

Musculoskeletal disorders, stress and performance anxiety are common in musicians. Therefore, some use the Alexander Technique (AT), a psycho-physical method that helps to release unnecessary muscle tension and re-educates non-beneficial movement patterns through intentional inhibition of unwanted habitual behaviours. According to a recent review AT sessions may be effective for chronic back pain. This review aimed to evaluate the evidence for the effectiveness of AT sessions on musicians' performance, anxiety, respiratory function and posture. The following electronic databases were searched up to February 2014 for relevant publications: PUBMED, Google Scholar, CINAHL, EMBASE, AMED, PsycINFO and RILM. The search criteria were "Alexander Technique" AND "music*". References were searched, and experts and societies of AT or musicians' medicine contacted for further publications. 237 citations were assessed. 12 studies were included for further analysis, 5 of which were randomised controlled trials (RCTs), 5 controlled but not randomised (CTs), and 2 mixed methods studies. Main outcome measures in RCTs and CTs were music performance, respiratory function, performance anxiety, body use and posture. Music performance was judged by external experts and found to be improved by AT in 1 of 3 RCTs; in 1 RCT comparing neurofeedback (NF) to AT, only NF caused improvements. Respiratory function was investigated in 2 RCTs, but not improved by AT training. Performance anxiety was mostly assessed by questionnaires and decreased by AT in 2 of 2 RCTs and in 2 of 2 CTs. A variety of outcome measures has been used to investigate the effectiveness of AT sessions in musicians. Evidence from RCTs and CTs suggests that AT sessions may improve performance anxiety in musicians. Effects on music performance, respiratory function and posture yet remain inconclusive. Future trials with well-established study designs are warranted to further and more reliably explore the potential of AT in the

Riding on the Back of a Giant: Adding Malta to the "5 Cultures" Study by Robin Alexander

ERIC Educational Resources Information Center

Peresso, Randolph

2017-01-01

This paper focuses on the methodology adopted for Malta+5, which builds on Robin Alexander's work by comparing the five pedagogical cultures he studied to the one in Malta. It reflects critically on the research process adopted in this study, and shows how, despite the very limited experience and resources, applying the methodology, frameworks and…

Leadership Content Knowledge for Literacy: Connecting Literacy Teachers and Their Principals

ERIC Educational Resources Information Center

Overholt, Rebecca; Szabocsik, Sandra

2013-01-01

The following vignette relates Becky Overholt's experience during a formal observation by her principal. At the time, Becky had a master's degree in curriculum, was a sixth-grade language arts teacher, and had 20 years of teaching experience. (Contains 1 table and 1 figure.)

Test Operations Procedure (TOP) 05-2-543 Enhanced Flight Termination Receiver (EFTR) Range Certification Testing

DTIC Science & Technology

2011-07-25

testing, the EFTR must be keyed with the same key used to encrypt the Enhanced Flight Termination Systems ( EFTS ) message. To ensure identical keys...required to verify the proper state. e. Procedure. (1) Pull up EFTS graphic user interface (GUI) (Figure 3). (2) Click “Receiver Power On...commanded mode steady state input currents will not exceed their specified values. TOP 05-2-543 25 July 2011 19 Figure 3. EFTS GUIa

Dr. Charles Alexander Eastman, Sioux Physician-Author, 1858-1939. With Teacher's Guide. Native Americans of the Twentieth Century.

ERIC Educational Resources Information Center

Minneapolis Public Schools, MN.

A biography for elementary school students of a 19th century American Indian physician and author, Charles Alexander Eastman (Sioux), includes photographs of Dr. Eastman and his wife. A teacher's guide following the bibliography contains information on the Sioux Uprising of 1862 and the Wounded Knee Massacre, learning objectives and directions for…

What is the alternative to the Alexander-Orbach relation?

NASA Astrophysics Data System (ADS)

Sokolov, Igor M.

2016-03-01

The Alexander-Orbach (AO) relation d w = 2d f /d s connecting the fractal dimension of a random walk’s (RW) trajectory d w or the exponent of anomalous diffusion α = 2/d w on a fractal structure with the fractal and spectral dimension of the structure itself plays a key role in discussion of dynamical properties of complex systems including living cells and single biomolecules. This relation however does not hold universally and breaks down for some structures like diffusion limited aggregates and Eden trees. We show that the alternative to the AO relation is the explicit dependence of the coefficient of the anomalous diffusion on the system’s size, i.e. the absence of its thermodynamical limit. The prerequisite for its breakdown is the dependence of the local structure of possible steps of the RW on the system’s size. The discussion is illustrated by the examples of diffusion on a Koch curve (AO-conform) and on a Cantor dust (violating AO relation).

Teaching Nuclear Radiation and the Poisoning of Alexander Litvinenko

NASA Astrophysics Data System (ADS)

Lapp, David R.

2008-03-01

The recent international story about the death of the former KGB agent Alexander Litvinenko has more than just a few wondering about radiation poisoning and the sinister sounding polonium-210. I was preparing to begin a nuclear radiation unit the Monday after Thanksgiving 2006. As it turned out, Litvinenko died Thanksgiving Day after a short and terrible three-week illness. Having the story continue to unfold throughout the next two weeks of the new unit provided a daily opportunity for students to see the relevance of what we were doing in class. My students were able to have meaningful and informed conversations with their peers and parents over an important international event. They even began to feel a bit like authorities themselves when listening to experts respond to media questions about polonium-210 and nuclear radiation in general. This paper discusses some of the ways that the story of Litvinenko was used while presenting the topic of nuclear radiation.

Alexander fractional differential window filter for ECG denoising.

PubMed

Verma, Atul Kumar; Saini, Indu; Saini, Barjinder Singh

2018-06-01

The electrocardiogram (ECG) non-invasively monitors the electrical activities of the heart. During the process of recording and transmission, ECG signals are often corrupted by various types of noises. Minimizations of these noises facilitate accurate detection of various anomalies. In the present paper, Alexander fractional differential window (AFDW) filter is proposed for ECG signal denoising. The designed filter is based on the concept of generalized Alexander polynomial and the R-L differential equation of fractional calculus. This concept is utilized to formulate a window that acts as a forward filter. Thereafter, the backward filter is constructed by reversing the coefficients of the forward filter. The proposed AFDW filter is then obtained by averaging of the forward and backward filter coefficients. The performance of the designed AFDW filter is validated by adding the various type of noise to the original ECG signal obtained from MIT-BIH arrhythmia database. The two non-diagnostic measure, i.e., SNR, MSE, and one diagnostic measure, i.e., wavelet energy based diagnostic distortion (WEDD) have been employed for the quantitative evaluation of the designed filter. Extensive experimentations on all the 48-records of MIT-BIH arrhythmia database resulted in average SNR of 22.014 ± 3.806365, 14.703 ± 3.790275, 13.3183 ± 3.748230; average MSE of 0.001458 ± 0.00028, 0.0078 ± 0.000319, 0.01061 ± 0.000472; and average WEDD value of 0.020169 ± 0.01306, 0.1207 ± 0.061272, 0.1432 ± 0.073588, for ECG signal contaminated by the power line, random, and the white Gaussian noise respectively. A new metric named as morphological power preservation measure (MPPM) is also proposed that account for the power preservance (as indicated by PSD plots) and the QRS morphology. The proposed AFDW filter retained much of the original (clean) signal power without any significant morphological distortion as validated by MPPM measure that were 0

Mythorealistic Concept of "Beautiful Lady" in the Structure of the Author's Identity (Based on the Diaries of Alexander Blok)

ERIC Educational Resources Information Center

Minets, Diana

2016-01-01

The present paper deals with the diaries of Alexander Blok dated 1901-1921 reflecting the process of the writer's self-identification. During 20 years under the influence of various social and cultural situations Blok's "Self-Conception" is undergoing significant changes. The vector of these changes shows the complicated evolution of the…

On the Social Psychology of Higher Education: A Bibliography of Alexander W. Astin. Public Administration Series Bibliography, P-688.

ERIC Educational Resources Information Center

Quay, Richard H.

A bibliography of articles by Alexander W. Astin on the social psychology of higher education is presented. Entries are presented by year, starting with 1980 and dating back to 1956. Topics that are covered include: equal access to higher education, student persistence and attrition, higher education policy, selective admissions and open…

Silurian trace fossils in carbonate turbidites from the Alexander Arc of southeastern Alaska

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soja, C.M.

Early to Late Silurian (Wenlock-Ludlow) body and trace fossils from the Heceta Formation are preserved in the oldest widespread carbonates in the Alexander terrane of southeastern Alaska. They represent the earliest shelly benthos to inhabit a diversity of marine environments and are important indicators of the early stages in benthic community development within this ancient island arc. The trace fossils are significant because they add to a small but growing body of knowledge about ichnofaunas in deep-water Paleozoic carbonates. Proximal to medial carbonate turbidites yield a low-diversity suite of trace fossils that comprises five distinct types of biogenic structures. Beddingmore » planes reveal simple epichnial burrows (Planolites), cross-cutting burrows (Fucusopsis), and tiny cylindrical burrows. These and other casts, including chondrites( )-like burrow clusters, represent the feeding activities (fodinichnia) of preturbidite animals. Hypichnial burrows and rare endichnial traces reflect the activities of postturbidite animals. Broken and offset traces indicate that infaunal biota commenced burrowing before slumping and subsequent soft-sediment deformation. The abundance and density of trace fossils increases offshore in the medial turbidites associated with a decrease in the size and amount of coarse particles and with an increase in mud and preserved organic material. Although diversity levels are similar in the proximal and medial turbidite facies, they are much lower than in Paleozoic siliciclastic turbidites. This may reflect unfavorable environmental conditions for infaunal biota or paleobiogeographic isolation of the Alexander terrane during the Silurian. A greater use of trace fossils in terrane analysis will help to resolve this issue and should provide new data for reconstructing the paleogeography of circum-Pacific terranes.« less

The generation of a continuous-wave Nd:YVO4/LBO laser at 543 nm by direct in-band diode pumping at 888 nm

NASA Astrophysics Data System (ADS)

Fu, S. C.; Wang, X.; Chu, H.

2013-02-01

We report the generation of a green laser at 543 nm by intracavity frequency doubling of the continuous-wave (cw) laser operation of a 1086 nm Nd:YVO4 laser under 888 nm diode pumping into the emitting level 4F3/2. An LiB3O5 (LBO) crystal, cut for critical type I phase matching at room temperature, is used for the laser second-harmonic generation. At an incident pump power of 17.8 W, as high as 4.53 W cw output power at 543 nm is achieved. The optical-to-optical conversion efficiency is up to 25.4%, and the fluctuation of the green output power is better than 2.3% in a 30 min period.

Bokan Mountain peralkaline granitic complex, Alexander terrane (southeastern Alaska): evidence for Early Jurassic rifting prior to accretion with North America

USGS Publications Warehouse

Dostal, Jaroslav; Karl, Susan M.; Keppie, J. Duncan; Kontak, Daniel J.; Shellnutt, J. Gregory

2013-01-01

The circular Bokan Mountain complex (BMC) on southern Prince of Wales Island, southernmost Alaska, is a Jurassic peralkaline granitic intrusion about 3 km in diameter that crosscuts igneous and metasedimentary rocks of the Alexander terrane. The BMC hosts significant rare metal (rare earth elements, Y, U, Th, Zr, and Nb) mineralization related to the last stage of BMC emplacement. U–Pb (zircon) and 40Ar/39Ar (amphibole and whole-rock) geochronology indicates the following sequence of intrusive activity: (i) a Paleozoic basement composed mainly of 469 ± 4 Ma granitic rocks; (ii) intrusion of the BMC at 177 ± 1 Ma followed by rapid cooling through ca. 550 °C at 176 ± 1 Ma that was synchronous with mineralization associated with vertical, WNW-trending pegmatites, felsic dikes, and aegirine–fluorite veins and late-stage, sinistral shear deformation; and (iii) intrusion of crosscutting lamprophyre dikes at >150 Ma and again at ca. 105 Ma. The peralkaline nature of the BMC and the WNW trend of associated dikes suggest intrusion during NE–SW rifting that was followed by NE–SW shortening during the waning stages of BMC emplacement. The 177 Ma BMC was synchronous with other magmatic centres in the Alexander terrane, such as (1) the Dora Bay peralkaline stock and (2) the bimodal Moffatt volcanic suite located ∼30 km north and ∼100 km SE of the BMC, respectively. This regional magmatism is interpreted to represent a regional extensional event that precedes deposition of the Late Jurassic – Cretaceous Gravina sequence that oversteps the Wrangellia and Alexander exotic accreted terranes and the Taku and Yukon–Tanana pericratonic terranes of the Canadian–Alaskan Cordillera.

Bokan Mountain peralkaline granitic complex, Alexander terrane (southeastern Alaska): evidence for Early Jurassic rifting prior to accretion with North America

USGS Publications Warehouse

Dostal, Jaroslav; Karl, Susan M.; Keppie, J. Duncan; Kontak, Daniel J.; Shellnutt, J. Gregory

2013-01-01

The circular Bokan Mountain complex (BMC) on southern Prince of Wales Island, southernmost Alaska, is a Jurassic peralkaline granitic intrusion about 3 km in diameter that crosscuts igneous and metasedimentary rocks of the Alexander terrane. The BMC hosts significant rare metal (rare earth elements, Y, U, Th, Zr, and Nb) mineralization related to the last stage of BMC emplacement. U–Pb (zircon) and 40Ar/39Ar (amphibole and whole-rock) geochronology indicates the following sequence of intrusive activity: (i) a Paleozoic basement composed mainly of 469 ± 4 Ma granitic rocks; (ii) intrusion of the BMC at 177 ± 1 Ma followed by rapid cooling through ca. 550 °C at 176 ± 1 Ma that was synchronous with mineralization associated with vertical, WNW-trending pegmatites, felsic dikes, and aegirine–fluorite veins and late-stage, sinistral shear deformation; and (iii) intrusion of crosscutting lamprophyre dikes at >150 Ma and again at ca. 105 Ma. The peralkaline nature of the BMC and the WNW trend of associated dikes suggest intrusion during NE–SW rifting that was followed by NE–SW shortening during the waning stages of BMC emplacement. The 177 Ma BMC was synchronous with other magmatic centres in the Alexander terrane, such as (1) the Dora Bay peralkaline stock and (2) the bimodal Moffatt volcanic suite located ~30 km north and ~100 km SE of the BMC, respectively. This regional magmatism is interpreted to represent a regional extensional event that precedes deposition of the Late Jurassic – Cretaceous Gravina sequence that oversteps the Wrangellia and Alexander exotic accreted terranes and the Taku and Yukon–Tanana pericratonic terranes of the Canadian–Alaskan Cordillera.

Possible refugia in the Alexander Archipelago of southeastern Alaska during the late Wisconsin glaciation

USGS Publications Warehouse

Carrara, P.E.; Ager, T.A.; Baichtal, J.F.

2007-01-01

The interpretation of the extent of late Wisconsin glaciation in southeastern Alaska has varied between geologists and biologists. Maps and reports of the region prepared by geologists commonly indicated that late Wisconsin ice extended as a large uniform front west to the edge of the continental shelf. However, the distribution of plants and animals in the region has led many biologists to suggest that there may have been ice-free areas that served as refugia during the late Wisconsin. Based on analyses of aerial photographs, topographic maps, and bathymetric charts, in conjunction with a review of previous literature and reconnaissance fieldwork throughout the region, this study presents data supporting a limited ice extent in the Alexander Archipelago during the late Wisconsin and identifies possible ice-free areas that may have served as refugia. These areas include (1) the Fairweather Ground, (2) the Herbert Graves Island area, (3) the western coast of southern Baranof Island and adjacent continental shelf, (4) Coronation Island and the adjacent continental shelf, (5) the Warren Island area, (6) the continental shelf from west of Heceta Island to Forrester Island in the south, (7) parts of the west coast of southern Dall Island, and (8) lowland areas in southern Prince of Wales Island. The identification of these possible refugia has bearing on the recolonization of the Alexander Archipelago, as they could have served as centers of biotic dispersal upon regional deglaciation and as stepping stones for early humans with a maritime tradition entering the western hemisphere from Asia. ?? 2007 NRC Canada.

Growing Community: The Impact of the Stephanie Alexander Kitchen Garden Program on the Social and Learning Environment in Primary Schools

ERIC Educational Resources Information Center

Block, Karen; Gibbs, Lisa; Staiger, Petra K.; Gold, Lisa; Johnson, Britt; Macfarlane, Susie; Long, Caroline; Townsend, Mardie

2012-01-01

This article presents results from a mixed-method evaluation of a structured cooking and gardening program in Australian primary schools, focusing on program impacts on the social and learning environment of the school. In particular, we address the Stephanie Alexander Kitchen Garden Program objective of providing a pleasurable experience that has…

Alexander Hegedus Lightning Talk: Integrating Measurements to Optimize Space Weather Strategies

NASA Astrophysics Data System (ADS)

Hegedus, A. M.

2017-12-01

Alexander Hegedus is a PhD Candidate at the University of Michigan, and won an Outstanding Student Paper Award at the AGU 2016 Fall Meeting for his poster "Simulating 3D Spacecraft Constellations for Low Frequency Radio Imaging." In this short talk, Alex outlines his current research of analyzing data from both real and simulated instruments to answer Heliophysical questions. He then sketches out future plans to simulate science pipelines in a real-time data assimilation model that uses a Bayesian framework to integrate information from different instruments to determine the efficacy of future Space Weather Alert systems. MHD simulations made with Michigan's own Space Weather Model Framework will provide input to simulated instruments, acting as an Observing System Simulation Experiment to verify that a certain set of measurements can accurately predict different classes of Space Weather events.

The metallogeny of Late Triassic rifting of the Alexander terrane in southeastern Alaska and northwestern British Columbia

USGS Publications Warehouse

Taylor, C.D.; Premo, W.R.; Meier, A.L.; Taggart, J.E.

2008-01-01

A belt of unusual volcanogenic massive sulfide (VMS) occurrences is located along the eastern margin of the Alexander terrane throughout southeastern Alaska and northwestern British Columbia and exhibits a range of characteristics consistent with a variety of syngenetic to epigenetic deposit types. Deposits within this belt include Greens Creek and Windy Craggy, the economically most significant VMS deposit in Alaska and the largest in North America, respectively. The occurrences are hosted by a discontinuously exposed, 800-km-long belt of rocks that consist of a 200- to 800-m-thick sequence of conglomerate, limestone, marine elastic sedimentary rocks, and tuff intercalated with and overlain by a distinctive unit of mafic pyroclastic rocks and pillowed flows. Faunal data bracket the age of the host rocks between Anisian (Middle Triassic) and late Norian (late Late Triassic). This metallogenic belt is herein referred to as the Alexander Triassic metallogenic belt. The VMS occurrences show systematic differences in degree of structural control, chemistry, and stratigraphic setting along the Alexander Triassic metallogenic belt that suggest important spatial or temporal changes in the tectonic environment of formation. At the southern end of the belt, felsic volcanic rocks overlain by shallow-water limestones characterize the lower part of the sequence. In the southern and middle portion of the belt, a distinctive pebble conglomerate marks the base of the section and is indicative of high-energy deposition in a near slope or basin margin setting. At the northern end of the belt the conglomerates, limestones, and felsic volcanic rocks are absent and the belt is composed of deep-water sedimentary and mafic volcanic rocks. This northward change in depositional environment and lithofacies is accompanied by a northward transition from epithermal-like structurally controlled, discontinuous, vein- and pod-shaped, Pb-Zn-Ag-Ba-(Cu) occurrences with relatively simple mineralogy

The D543N polymorphism of the SLC11A1/NRAMP1 gene is associated with treatment failure in male patients with pulmonary tuberculosis.

PubMed

Salinas-Delgado, Yvain; Galaviz-Hernández, Carlos; Toral, René García; Ávila Rejón, Carmen A; Reyes-Lopez, Miguel A; Martínez, Antonio Rojas; Martínez-Aguilar, Gerardo; Sosa-Macías, Martha

2015-09-01

Polymorphisms in SLC11A1/NRAMP1 have shown an important association with susceptibility to tuberculosis and progression to active disease. However, whether there is an association of these polymorphisms with treatment failure is unknown. The aim of this study was to determine the association of SLC11A1 polymorphisms with treatment failure in Mexican subjects with pulmonary tuberculosis. Thirty-three subjects with treatment failure were paired by age and body mass index with 33 patients who successfully completed treatment and were considered cured. We assessed the polymorphisms of SLC11A1 in the regions of D543N and INT4 via polymerase chain reaction real-time TaqMan® single nucleotide polymorphism (SNP) genotyping. We found that D543N (G/A genotype) was associated with treatment failure in patients with pulmonary tuberculosis [odds ratio (OR) 11.61, 95% confidence interval (CI) 3.66-36.78]. When adjusted by gender, this association remained significant in males (OR 11.09, 95% CI 3.46-35.51). In our male population, the presence of the D543N polymorphism of SLC11A1 is a risk factor for treatment failure. This finding should be confirmed in other populations.

31 CFR 560.543 - Sale of certain real property in Iran and transfer of related funds to the United States.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Sale of certain real property in Iran... Statements of Licensing Policy § 560.543 Sale of certain real property in Iran and transfer of related funds... necessary and ordinarily incident to the sale of real property in Iran and to transfer the proceeds to the...

31 CFR 560.543 - Sale of certain real property in Iran and transfer of related funds to the United States.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Sale of certain real property in Iran... Statements of Licensing Policy § 560.543 Sale of certain real property in Iran and transfer of related funds... necessary and ordinarily incident to the sale of real property in Iran and to transfer the proceeds to the...

Bryan Coast, English Coast, Alexander Island, Fallieres Coast, and Bellingshausen Sea, Antarctica

NASA Technical Reports Server (NTRS)

2002-01-01

This image of Antarctica shows the Bryan Coast (lower left), the English Coast (lower central), Alexander Island (middle right), the Fallieres Coast (top right), and the Bellingshausen Sea. The entire continent has been dedicated to peaceful scientific investigation since 1961, with the signing of the Antarctic Treaty.The waters surrounding Antarctica are intensely cold. Salt water freezes at -2C, allowing sea ice to form. The middle left portion of the image shows quite a lot of sea ice in the Bellingshausen Sea. During the Antarctic winter, when data for this image was acquired, Antarctica doubles in size to about 28.5 million square km (or about 11 million square miles), and temperatures in the -60C range are common.This true-color image was compiled from MODIS data gathered March 29, 2002. Credit: Jacques Descloitres, MODIS Land Rapid Response Team, NASA/GSFC

The chemical work of Alexander and Jane Marcet.

PubMed

Rosenfeld, L

2001-04-01

Alexander Marcet was an authority on urinary calculi and their analysis when few medical practitioners appreciated the usefulness of chemistry in the explanation and treatment of disease. In An Essay on The Chemical History and Medical Treatment of Calculous Disorders, he described the discovery of an xanthine stone. He drew line illustrations of simple chemical apparatus useful for bedside analysis. His microtechnique used drops of solution and pinhead pieces of calculi; reagents were acids and alkalies and the blowpipe in conjunction with a small alcohol lamp. He reported the earliest description of a disorder later named "alcaptonuria". Marcet's work and that of a few others, on the chemical composition of urine and calculi, laid the foundations of our present knowledge. Between 1807 and 1820, his lectures to the medical students at Guy's Hospital were illustrated by experiments. Jane Haldimand Marcet wrote the very popular CONVERSATIONS: on Chemistry (16 editions in Great Britain). Her book dominated elementary chemical instruction during the first half of the 19th century. She followed Lavoisier's scheme of classification and explained chemical reactions in terms of affinity, aggregation, gravitation, and repulsion. Her advocacy that experimentation accompany lecture was new. The availability of serious scientific education in the new women's academies set the stage for increasing women's involvement in science. She also published a series of CONVERSATIONS: The topics were Political Economy, Natural Philosophy, and Vegetable Physiology.

Impact of the Alexander technique on well-being: a randomised controlled trial involving older adults with visual impairment.

PubMed

Gleeson, Michael; Sherrington, Catherine; Lo, Serigne; Auld, Robin; Keay, Lisa

2017-11-01

Older adults with visual loss have high rates of depression, restricted participation and reduced quality of life. We sought to measure the impact of lessons in the Alexander technique on vision-related emotional and social well-being, as secondary outcomes to a study on improving physical functioning in this population. This is a single-blind randomised controlled trial. One hundred and twenty community-dwelling adults aged 50 to 90 years with visual impairments were randomised to either 12 Alexander lessons over 12 weeks and usual care or usual care. The Perceived Visual Ability Scale, the Keele Assessment of Participation, the emotional subscale of the Impact of Vision Impairment Profile, the Positive and Negative Affect Scale and the five-item Geriatric Depression Scale were administered at baseline and three and 12 months. Participants were receiving services from Guide Dogs NSW/ACT. None of the validated questionnaires found statistically significant improvements after adjustment for baseline at three or 12 months, although the emotional subscale of the Impact of Vision Impairment approached significance in favour of the intervention group (4.54 points, 95 per cent CI: -0.14 to 9.21, p = 0.06). Depressive symptoms were prevalent and associated with greater impact of visual impairment on emotional well-being (odds ratio: 1.12, 95 per cent CI: 1.07 to 1.17, p < 0.0001). Faster gait, an indicator of general mobility, was associated with less depressive symptoms (odds ratio: 1.27, 95 per cent CI: 1.06 to 1.54, p = 0.01). On average, there was no significant impact of weekly lessons in the Alexander technique on social and emotional well-being, although the emotional impact of visual impairment showed a trend toward less distress in the intervention group. Our data found that emotional distress associated with visual impairment influences depressive symptoms but contrary to expectations, the level of social support received was not significant

Improving Learning Outcomes, Persistence, and Graduation Rates of Academically Underprepared Students: a Case Study of Alexander Community College and Its Developmental Education Effort

ERIC Educational Resources Information Center

Marchione, Susan M.

2012-01-01

This case study describes how Alexander Community College (ACC), a two-year State University of New York (SUNY) institution is addressing challenges associated with its developmental education effort--primarily high costs for repeated developmental (assumed by the institution and students) and low persistence and graduation rates for developmental…

Exploring the psychological processes underlying touch: lessons from the Alexander Technique.

PubMed

Jones, T; Glover, L

2014-01-01

The experience of touch is significant; both in its positive implications and in how it attracts caution and controversy. Accordingly, physical contact within psychological therapy has been shown to improve well-being and the therapeutic relationship, yet the majority of therapists never or rarely use touch. This research aimed to explore psychological processes underlying touch through the Alexander Technique, a psycho-physical technique taught one to one using touch. Six individuals who had received the Alexander Technique were interviewed, and 111 completed surveys. Interview data suggested an incompatibility between touch and the spoken word, which was understood through the way touch lacks verbal discourses in our society. The largely simplistic and dichotomous verbal understanding we have (either only very positive or very negative) could help understand some of the societal-level caution surrounding touch. Touch was seen also as a nurturing experience by interviewees, which influenced inter-personal and intra-personal relational processes. Developmental models were used to frame the way touch strengthened the pupil-teacher relationship and the way pupils' intra-personal psychological change seemed linked to this relational experience. The surveys largely supported these findings, and discussion is made around the notable way pupils negatively interpreted the intention of the survey. Implications for the use of touch in psychological therapies are discussed, as are limitations and ideas for future research. Touch is a powerful experience, and physical contact within psychological therapy has been shown to improve well-being and the therapeutic relationship, yet the majority of therapists never or rarely use touch. The AT is an alternative therapeutic approach to psycho-physical well-being that offers an interesting model to study the impact of touch. Findings from those that have used the technique reaffirmed that touch can improve well-being and can be a

Prevention and Early Intervention: Individual Differences as Risk Factors for the Mental Health of Children. A Festschrift for Stella Chess and Alexander Thomas.

ERIC Educational Resources Information Center

Carey, William B., Ed.; McDevitt, Sean C., Ed.

This collection of essays, in honor of child psychiatry pioneers Stella Chess and Alexander Thomas, focuses on their idea that important life outcomes are the product of ongoing interactions between a child's behavioral style and the complimentarity or lack of fit of the parenting environment. Following an introduction, the remaining chapters are:…

Finding revelation in anthropology: Alexander Winchell, William Robertson Smith and the heretical imperative.

PubMed

Livingstone, David N

2015-09-01

Anthropological inquiry has often been considered an agent of intellectual secularization. Not least is this so in the sphere of religion, where anthropological accounts have often been taken to represent the triumph of naturalism. This metanarrative, however, fails to recognize that naturalistic explanations could sometimes be espoused for religious purposes and in defence of confessional creeds. This essay examines two late nineteenth-century figures--Alexander Winchell in the United States and William Robertson Smith in Britain--who found in anthropological analysis resources to bolster rather than undermine faith. In both cases these individuals found themselves on the receiving end of ecclesiastical censure and were dismissed from their positions at church-governed institutions. But their motivation was to vindicate divine revelation, in Winchell's case from the physical anthropology of human origins and in Smith's from the cultural anthropology of Semitic ritual.

Non-Euclidean Space, Movement and Astronomy in Modern Art: Alexander Calder's Mobiles and Ben Nicholson's Reliefs

NASA Astrophysics Data System (ADS)

Malloy, Vanja

2013-09-01

John Keats once wrote that `there is no such thing as time and space' rather, believing that time and space are mental constructs that are subject to a variety of forms and as diverse as the human mind. In the 1920s through the 1930s, modern physics in many ways supported this idea through the various philosophical writings on the Theory of General Relativity to the masses by scientists such as Arthur Eddington and Albert Einstein. These new concepts of modern physics fundamentally changed our understanding of time and space and had substantial philosophical implications, which were absorbed by modern artists resulting in the 1936 Dimensionist Manifesto. Seeking to internalize the developments of modern science within modern art, this manifesto was widely endorsed by the most prominent figures of the avant-garde such as Marcel Duchamp, Jean Arp, Naum Gabo, Joan Miró, László Moholy-Nagy, Wassily Kandinsky and Alexander Calder. Of particular interest to this manifesto was the new concept of the fourth-dimension, which in many ways revolutionized the arts. Importantly, its interpretation varied widely in the artistic community, ranging from a purely physical four-dimensional space, to a kinetic concept of space in which space and time are linked, to a metaphysical interest in a space that exists beyond the material realm. The impact of modern science and astronomy on avant-garde art is currently a bourgeoning area of research with considerable implications to our rethinking of substantial artistic figures of this era. Through a case study of Alexander Calder's Mobiles and Ben Nicholson's Reliefs, this paper explores how these artworks were informed by an interest in modern science.

El administrador Pruitt anuncia $54.3 millones en subvenciones Brownfields para evaluar y limpiar las propiedades contaminadas y promover el redesarrollo económico a nivel nacional

EPA Pesticide Factsheets

Comunicado de prensa de la EPA: El administrador Pruitt anuncia $54.3 millones en subvenciones Brownfields para evaluar y limpiar las propiedades contaminadas y promover el redesarrollo económico a nivel nacional

Zanvil Alexander Cohn 1926-1993

PubMed Central

1994-01-01

Zanvil Alexander Cohn, an editor of this Journal since 1973, died suddenly on June 28, 1993. Cohn is best known as the father of the current era of macrophage biology. Many of his scientific accomplishments are recounted here, beginning with seminal studies on the granules of phagocytes that were performed with his close colleague and former editor of this Journal, James Hirsch. Cohn and Hirsch identified the granules as lysosomes that discharged their contents of digestive enzymes into vacuoles containing phagocytosed microbes. These findings were part of the formative era of cell biology and initiated the modern study of endocytosis and cell-mediated resistance to infection. Cohn further explored the endocytic apparatus in pioneering studies of the mouse peritoneal macrophage in culture. He described vesicular inputs from the cell surface and Golgi apparatus and documented the thoroughness of substrate digestion within lysosomal vacuoles that would only permit the egress of monosaccharides and amino acids. These discoveries created a vigorous environment for graduate students, postdoctoral fellows, and junior and visiting faculty. Some of the major findings that emerged from Cohn's collaborations included the radioiodination of the plasma membrane for studies of composition and turnover; membrane recycling during endocytosis; the origin of the mononuclear phagocyte system in situ; the discovery of the dendritic cell system of antigen-presenting cells; the macrophage as a secretory cell, including the release of proteases and large amounts of prostaglandins and leukotrienes; several defined parameters of macrophage activation, especially the ability of T cell-derived lymphokines to enhance killing of tumor cells and intracellular protozoa; the granule discharge mechanism whereby cytotoxic lymphocytes release the pore-forming protein perforin; the signaling of macrophages via myristoylated substrates of protein kinase C; and a tissue culture model in which

KSC-08pd0164

NASA Image and Video Library

2008-02-06

KENNEDY SPACE CENTER, FLA. -- On the flight deck of space shuttle Atlantis, STS-122 Mission Specialist Hans Schlegel handles the camera to be used during the mission. Schlegel represents the European Space Agency. The STS-122 mission to the International Space Station is scheduled to launch at 2:45 p.m. Feb. 7 with a crew of seven. Atlantis will carry the Columbus Laboratory, Europe's largest contribution to the construction of the station. Columbus will support scientific and technological research in a microgravity environment. Columbus is a multifunctional, pressurized laboratory that will be permanently attached to the Harmony module to carry out experiments in materials science, fluid physics and biosciences, as well as to perform a number of technological applications. Photo credit: NASA/Kim Shiflett

KSC-99pc0164

NASA Image and Video Library

1999-02-06

KENNEDY SPACE CENTER, FLA. -- The Chandra X-ray Observatory is unloaded from an Air Force C-5 Galaxy transporter two days after landing at the Shuttle Landing Facility on Feb. 4. The observatory sits cradled in the cargo hold of a tractor-trailer rig called the Space Cargo Transportation System, which closely resembles the size and shape of the Shuttle cargo bay. In the background (left) is the mate-demate device, used when an orbiter is returned to KSC on the back of a Shuttle carrier aircraft. Over the next few months, Chandra will undergo final tests and be mated to a Boeing-provided Inertial Upper Stage for launch July 9 aboard Space Shuttle Columbia, on mission STS-93 . Formerly called the Advanced X-ray Astrophysics Facility, Chandra comprises three major elements: the spacecraft, the science instrument module (SIM), and the world's most powerful X-ray telescope. Chandra will allow scientists from around the world to see previously invisible black holes and high-temperature gas clouds, giving the observatory the potential to rewrite the books on the structure and evolution of our universe

KSC-06pd0164

NASA Image and Video Library

2006-01-12

VANDENBERG AIR FORCE BASE, Calif. — In the Orbital Sciences Building 836 at Vandenberg Air Force Base in California, workers are maneuvering a second satellite suspended by an overhead crane. Three micro-satellites are being mounted on a payload support structure. The three satellites make up the Space Technology 5 spacecraft, called ST5, and will be launched by a Pegasus XL rocket. The satellites contain miniaturized redundant components and technologies. Each will validate New Millennium Program selected technologies, such as the Cold Gas Micro-Thruster and X-Band Transponder Communication System. After deployment from the Pegasus, the micro-satellites will be positioned in a “string of pearls” constellation that demonstrates the ability to position them to perform simultaneous multi-point measurements of the magnetic field using highly sensitive magnetometers. The data will help scientists understand and map the intensity and direction of the Earth’s magnetic field, its relation to space weather events, and affects on our planet. With such missions, NASA hopes to improve scientists’ ability to accurately forecast space weather and minimize its harmful effects on space- and ground-based systems. Launch of ST5 is scheduled for Feb. 28 from Vandenberg Air Force Base.

KSC-03pd0164

NASA Image and Video Library

2003-01-16

KENNEDY SPACE CENTER, FLA. -- Workers in the Multi-Purpose Processing Facility look over the encapsulation of the Solar Radiation and Climate Experiment (SORCE) satellite. The satellite will next be installed in the Pegasus XL launch vehicle. Built by Orbital Sciences Corporation (OSC), SORCE will study and measure solar irradiance as a source of energy in the Earth's atmosphere. The launch of SORCE is scheduled for Jan. 25 at 3:14 p.m. from Cape Canaveral Air Force Station, Fla. The drop of the Pegasus will be from OSC's L-1011 aircraft at an altitude of 39,000 feet over the Atlantic Ocean approximately 100 miles east-southeast of Cape Canaveral.

Ice-dammed lateral lake and epishelf lake insights into Holocene dynamics of Marguerite Trough Ice Stream and George VI Ice Shelf, Alexander Island, Antarctic Peninsula

NASA Astrophysics Data System (ADS)

Davies, Bethan J.; Hambrey, Michael J.; Glasser, Neil F.; Holt, Tom; Rodés, Angél; Smellie, John L.; Carrivick, Jonathan L.; Blockley, Simon P. E.

2017-12-01

We present new data regarding the past dynamics of Marguerite Trough Ice Stream, George VI Ice Shelf and valley glaciers from Ablation Point Massif on Alexander Island, Antarctic Peninsula. This ice-free oasis preserves a geological record of ice stream lateral moraines, ice-dammed lakes, ice-shelf moraines and valley glacier moraines, which we dated using cosmogenic nuclide ages. We provide one of the first detailed sediment-landform assemblage descriptions of epishelf lake shorelines. Marguerite Trough Ice Stream imprinted lateral moraines against eastern Alexander Island at 120 m at Ablation Point Massif. During deglaciation, lateral lakes formed in the Ablation and Moutonnée valleys, dammed against the ice stream in George VI Sound. Exposure ages from boulders on these shorelines yielded ages of 13.9 to 9.7 ka. Following recession of the ice stream, George VI Ice Shelf formed in George VI Sound. An epishelf lake formed at 15-20 m asl in Ablation and Moutonnée valleys, dated from 9.4 to 4.6 ka, suggesting that the lake was stable and persistent for some 5000 years. Lake-level lowering occurred after this, with the lake level at 12 m at 3.1 ± 0.4 ka and at 5 m asl today. A readvance of the valley glaciers on Alexander Island at 4.4 ± 0.7 ka is recorded by valley glacier moraines overlying epishelf lake sediments. We speculate that the glacier readvance, which occurred during a period of warmth, may have been caused by a dynamic response of the glaciers to a lowering in surface elevation of George VI Ice Shelf.

Obituary: Alexander (Andy) Franz Lubenow, 1956-2005

NASA Astrophysics Data System (ADS)

Buie, Marc William

2006-12-01

Alexander (Andy) Franz Lubenow, Program Coordinator at the Space Telescope Science Institute, was diagnosed with cancer of the gallbladder, pancreas, and liver in May 2005 and died on 29 September 2005. He was forty-nine. Andy was born to Bodo and Helen Lubenow in St. Paul, Minnesota on 4 January 1956. In 1964 at the age of eight, he moved with his family to Buenos Aires, Argentina, and attended the American Community School there until returning with his family in 1973 to St. Paul. Argentina had a big impact on Andy's future as an astronomer. He later recalled how he had observed and was puzzled by the "upside-down" appearance of the Moon in the southern hemisphere. In Argentina, he built his first telescope using a mirror he had ground himself. He never parted ways with that instrument. Andy did not follow a standard educational track. He spent two years at St. Olaf College in Northfield, Minnesota, before transferring to the University of Minnesota, where he earned his bachelor's degree and began work towards a master's degree in astrophysics. Later he transferred to the University of Illinois at Urbana-Champaign, where he remained until Dr. Peter Stockman hired him to work on the Hubble Space Telescope project. While in school, he worked as a teacher's assistant, taught night school, and gave demonstrations of stargazing. He was an excellent teacher and had a flair for writing. He later wrote articles for a sailing magazine and a pilot's magazine. Andy was a very practical, meticulous, and steady worker, attributes that he combined with an understated and dry sense of humor. He was always able to find a way through a problem, no matter how sticky. If a job required him to roll up his sleeves and get it done through hard work, he would persevere. Nevertheless, he was always on the lookout for an easier way. He had no patience for being forced to deal with stupid things for stupid reasons. At work at the Space Telescope Science Institute (STScI), Andy was

The Question of Sign-Language and the Utility of Signs in the Instruction of the Deaf: Two Papers by Alexander Graham Bell (1898)

ERIC Educational Resources Information Center

Marschark, M.

2005-01-01

Alexander Graham Bell is often portrayed as either hero or villain of deaf individuals and the Deaf community. His writings, however, indicate that he was neither, and was not as clearly definite in his beliefs about language as is often supposed. The following two articles, reprinted from The Educator (1898), Vol. V, pp. 3?4 and pp. 38?44,…

Production of High Amounts of Hepatotoxin Nodularin and New Protease Inhibitors Pseudospumigins by the Brazilian Benthic Nostoc sp. CENA543

PubMed Central

Jokela, Jouni; Heinilä, Lassi M. P.; Shishido, Tânia K.; Wahlsten, Matti; Fewer, David P.; Fiore, Marli F.; Wang, Hao; Haapaniemi, Esa; Permi, Perttu; Sivonen, Kaarina

2017-01-01

Nostoc is a cyanobacterial genus, common in soils and a prolific producer of natural products. This research project aimed to explore and characterize Brazilian cyanobacteria for new bioactive compounds. Here we report the production of hepatotoxins and new protease inhibitors from benthic Nostoc sp. CENA543 isolated from a small, shallow, saline-alkaline lake in the Nhecolândia, Pantanal wetland area in Brazil. Nostoc sp. CENA543 produces exceptionally high amounts of nodularin-R. This is the first free-living Nostoc that produces nodularin at comparable levels as the toxic, bloom-forming, Nodularia spumigena. We also characterized pseudospumigins A–F, which are a novel family of linear tetrapeptides. Pseudospumigins are structurally related to linear tetrapeptide spumigins and aeruginosins both present in N. spumigena but differ in respect to their diagnostic amino acid, which is Ile/Leu/Val in pseudospumigins, Pro/mPro in spumigins, and Choi in aeruginosins. The pseudospumigin gene cluster is more similar to the spumigin biosynthetic gene cluster than the aeruginosin gene cluster. Pseudospumigin A inhibited trypsin (IC50 4.5 μM after 1 h) in a similar manner as spumigin E from N. spumigena but was almost two orders of magnitude less potent. This study identifies another location and environment where the hepatotoxic nodularin has the potential to cause the death of eukaryotic organisms. PMID:29062311

Neuromusicology or Musiconeurology? “Omni-art” in Alexander Scriabin as a Fount of Ideas

PubMed Central

Triarhou, Lazaros C.

2016-01-01

Science can uncover neural mechanisms by looking at the work of artists. The ingenuity of a titan of classical music, the Russian composer Alexander Scriabin (1872–1915), in combining all the sensory modalities into a polyphony of aesthetical experience, and his creation of a chord based on fourths rather than the conventional thirds are proposed as putative points of departure for insight, in future studies, into the neural processes that underlie the perception of beauty, individually or universally. Scriabin’s “Omni-art” was a new synthesis of music, philosophy and religion, and a new aesthetic language, a unification of music, vision, olfaction, drama, poetry, dance, image, and conceptualization, all governed by logic, in the quest for the integrative action of the human mind toward a “higher reality” of which music is only a component. PMID:27014167

Discuss: If Essays Are Dead, Then Where Does That Leave Everything Else? A Response to: Shirley Alexander's "Buying Essays: How to Make Sure Assessment Is Authentic"

ERIC Educational Resources Information Center

McQueen, Kelvin

2015-01-01

Professor Shirley Alexander is the Deputy Vice-Chancellor and Vice-President (Teaching, Learning & Equity) at the University of Technology, Sydney. On 12 November 2014, an article of hers appeared in "The Conversation": "Buying essays: how to make sure assessment is authentic." That article traverses, in an abbreviated way,…

2012 ARPA-E Energy Innovation Summit Keynote Presentation (Frederick W. Smith, FedEx Corporation), with Introduction by Senator Lamar Alexander (TN)

ScienceCinema

Smith, Frederick W.

2018-02-01

The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. Following introduction by Senator Lamar Alexander of Tennessee, Frederick W. Smith, Chairman, President, and CEO of FedEx Corporation, gave the third keynote presentation of the day.

Annotated translation of "Die Wasserversorgung einiger Nordseebäder [The water supply of some North Sea spas]" by Alexander Herzberg (1901)

NASA Astrophysics Data System (ADS)

Houben, Georg

2018-05-01

The publication "The water supply of some North Sea spas" by Alexander Herzberg in 1901 is a cornerstone of coastal groundwater research. It was fundamental to the development of the Ghijben-Herzberg principle, which describes the hydrostatic equilibrium between fresh and saline groundwater. Due to its age and the language barrier, the paper is often cited but probably rarely read. Therefore, the original paper has been translated from German into English, accompanied by an introduction and notes explaining the historical context.

IN MEMORIAM: In Memoriam: Alexander A Golovin and Alexei M Oparin In Memoriam: Alexander A Golovin and Alexei M Oparin

NASA Astrophysics Data System (ADS)

2008-10-01

In Memoriam of Alexander A Golovin (1962-2008) Alexander (Sasha) Golovin passed away on 10 September 2008. Sasha's scientific heritage includes seminal works in different fields of physics, from Marangoni convection to self-assembly of quantum dots, and from combustion fronts to anomalous diffusion in flows and on a crystal surface. A graduate of the Moscow Institute for Physics and Technology, he had very broad scientific interests and a unique ability to identify and solve new, intellectually challenging and technologically important problems. One of the basic fields of Sasha's research was the fluid dynamics in systems with interfaces. His favorite subject was the motion of droplets, bubbles and particles in the presence of heat and mass transfer. Sasha's early works contained the discovery of the spontaneous motion of droplets due to the Marangoni effect and the investigation of the interaction between solid particles, bubbles and droplets caused by the Marangoni effect, which is a crucial factor that determines the effect of heat/mass transfer on the rate of coalescence. In both cases, Sasha's work was the first in a long sequence of papers written by different authors. Later, Sasha returned to that field when studying such fascinating subjects as levitation of droplets above the surface of an evaporating liquid and encapsulation of particles and bubbles by an advancing solidification front. The subject of interfacial hydrodynamics overlaps with another basic field of Sasha's research, the theory of pattern formation. The contribution of Sasha's work to the modern understanding of the variety of pattern formation phenomena is significant. It includes the analysis of the interaction between long-wave and short-wave instability modes in Marangoni convection, investigation of the large-scale Marangoni convection that led to the prediction of different patterns including quasipatterns, and the description of various non-potential effects in Marangoni convection

[The life history of Alexander Numan (1780-1852) during his time in Groningen].

PubMed

Mathijsen, A H

2001-01-01

Until the time Numan took on his professorship at the newly established Veterinary School in Utrecht in 1822, he had lived in the Province of Groningen. In order to understand why the minister of Public Education appointed a village doctor from the north of the country as professor for the practice of veteriary medicine, and after some years as director of the school, it was felt essential to investigate his earlier life period. The main sources used are two obituaries, resp. written by his son who was a professor of Law at Groningen University, and by his friend prof. Willem Vrolik who was the secretary of the Academy of Science, supplemented by family histories and some archival research. After a short description of his descent, youth adn education follows the main part devoted to his writings, his medical practice and membership of the Provincial Medical Commission and the Commission for Agriculture. In an appendix some genealogical data are presented on the family of his wife and their children. Alexander lost his father, who was a minister of the Reformed Church, when he was ten years old. He received his education in the circle of family members. A brother of his father, also a minister, teached him Greek and Latin. After this uncle had left the province, he lived in the home of another minister who teached him the modern languages. As this man was involved in politics of the Baravian Republic, young Alexander was exposed to many discussions on the polity of the State. After his mother had remarried with a medical doctor, this man, and also his brother who had a medical practice in another part of the province, complemented the education with an introduction in the sciences. Experiences in their dispensaries, where some knowledge of botany and chemistry could be obtained, and discussions when accompanying them on their visits to patients, were decisive in the choice of his profession. Only at the age of twenty he entered the Medical Faculty of Groningen

Cyclicity in Silurian island-arc carbonates, Alexander terrane, Alaska

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kittredge, L.E.; Soja, C.M.

1993-03-01

Silurian carbonates from Alaska (Alexander terrane) record the evolution of a submarine platform during waning volcanism in an island arc. A detailed stratigraphic analysis of a 47 meter-thick sequence revealed the existence of cyclically repeated limestones: coral-stromatoporoid wackestones alternate with oncoid packstones and bioturbated, silty lime mudstones. The coral-stromatoporoid deposits are characterized by a low-diversity assemblage of dendroid corals, massive stromatoporoids, Atrypoidea brachiopods, and rare occurrences of biostromes associated with Solenopora, high-spired gastropods, and crinoids. Oncoids typically are 2-6 mm in diameter and form massive, meter-thick units. Coated grains are symmetrically developed, have a shell or algal nucleus, and aremore » also a minor component of coral-stromatoporoid beds. These lithologic units form seven, shallowing-upwards cycles (parasequences) that range in thickness from 3-9 meters. Coral-stomatoporoid wackestones form the base of each cycle and grade upwards into oncoid packstones with silty, lime mudstones at the top. This succession of lithofacies within each cycle reflects an increase in energy levels from relatively deeper water environments to relatively shallower ones. The lack of abrasion in the corals and stromatoporoids suggests predominantly quiet-water conditions in shallow subtidal areas affected by periodic turbulence. Comparison with correlative sections in Alaska and lack of correspondence with global sea level curves suggest that the primary cause of cyclicity was tectonic perturbations with secondary eustatic effects. Cyclic deposition in peri/subtidal sites was terminated by rapid drowning of the carbonate platform during late Silurian orogenesis.« less

Alexander Graham Bell's Patent for the Telephone and Thomas Edison's Patent for the Electric Lamp. The Constitution Community: The Development of the Industrial United States (1870-1900).

ERIC Educational Resources Information Center

Schur, Joan Brodsky

In 1876 Americans held a Centennial Exhibition in Philadelphia (Pennsylvania) to celebrate the nation's birth 100 years earlier. Machinery Hall drew the most admiration and wonder. Alexander Graham Bell exhibited the first telephone, and Thomas Alva Edison presented the automatic telegraph, one of more than 1,000 inventions he would patent in his…

The wounding of Alexander the Great in Cyropolis (329 BC): the first reported case of the syndrome of transient cortical blindness?

PubMed

Lascaratos, J

1997-01-01

I believe that the transient blindness which presented Alexander the Great after his being wounded on his head and/or his neck by a stone from a catapult during the siege of Cyropolis (329 BC) was in all probability a case of transient cortical blindness that was recognized as a special entity in the 1960s. I reached this conclusion after the comparative study of the Emperor's clinical picture provided by ancient texts, especially those of Plutarch and Quintus Curtius Rufus, with that of a modern medical bibliography.

The Cannery Formation--Devonian to Early Permian arc-marginal deposits within the Alexander Terrane, Southeastern Alaska

USGS Publications Warehouse

Karl, Susan M.; Layer, Paul W.; Harris, Anita G.; Haeussler, Peter J.; Murchey, Benita L.

2011-01-01

cherts on both Admiralty and Kupreanof Islands contain radiolarians as young as Permian, the age of the Cannery Formation is herein extended to Late Devonian through early Permian, to include the early Permian rocks exposed in its type locality. The Cannery Formation is folded and faulted, and its stratigraphic thickness is unknown but inferred to be several hundred meters. The Cannery Formation represents an extended period of marine deposition in moderately deep water, with slow rates of deposition and limited clastic input during Devonian through Pennsylvanian time and increasing argillaceous, volcaniclastic, and bioclastic input during the Permian. The Cannery Formation comprises upper Paleozoic rocks in the Alexander terrane of southeastern Alaska. In the pre-Permian upper Paleozoic, the tectonic setting of the Alexander terrane consisted of two or more evolved oceanic arcs. The lower Permian section is represented by a distinctive suite of rocks in the Alexander terrane, which includes sedimentary and volcanic rocks containing early Permian fossils, metamorphosed rocks with early Permian cooling ages, and intrusive rocks with early Permian cooling ages, that form discrete northwest-trending belts. After restoration of 180 km of dextral displacement of the Chilkat-Chichagof block on the Chatham Strait Fault, these belts consist, from northeast to southwest, of (1) bedded chert, siliceous argillite, volcaniclastic turbidites, pillow basalt, and limestone of the Cannery Formation and the Porcupine Slate of Gilbert and others (1987); (2) greenschist-facies Paleozoic metasedimentary and metavolcanic rocks that have Permian cooling ages; (3) silty limestone and calcareous argillite interbedded with pillow basalt and volcaniclastic rocks of the Halleck Formation and the William Henry Bay area; and (4) intermediate-composition and syenitic plutons. These belts correspond to components of an accretionary complex, contemporary metamorphic rocks, forearc-basin deposits,

Quantification of dynamic posterior translation in modified bilateral Alexander views and correlation with clinical and radiological parameters in patients with acute acromioclavicular joint instability.

PubMed

Minkus, Marvin; Hann, Carmen; Scheibel, Markus; Kraus, Natascha

2017-06-01

Classification of AC-joint instability is based on radiologic evaluation of anteroposterior (a.p.) stress views of both shoulders, neglecting the horizontal component of instability. Recent studies have proposed an association of dynamic posterior translation (DPT) and inferior clinical results. The purpose of this study was to quantify DPT in modified Alexander views and correlate it with other radiological and clinical data. Thirty-two patients (4 f, 28 m, mean age 34.1) with acute AC-joint dislocation (16 = RW III, 16 = RW V) underwent radiological examination including bilateral a.p. stress views with measurement of the coracoclavicular distance (CCD) and bilateral modified Alexander views with different approaches to quantify DPT (overlapping area OA AC , overlapping length OL AC ). In addition, the Constant Score, Subjective Shoulder Value, Taft Score (TF), and the Acromioclavicular Joint Instability Score (ACJI) were obtained. In Rockwood (RW) type III injuries, a mean CCD of 15.8 (9.8-22.8) mm, OA AC of 50.9 (0-216.6) mm 2 , and OL AC of 6.5 (-4.7-17.9) mm were found. RW V patients showed a CCD of 23.1 (13.7-32.0) mm; OA AC 7.0 (0-92.3) mm 2 ; and OL AC -4.8 (-19.6-9.8) mm. Particularly in RW III the CCD, OA AC and OL AC revealed significant correlation with the ACJI (r = -0.64/r = 0.72/r = 0.68, p < 0.05) and TF (r = -0.56/r = 0.68/r = 0.51, p < 0.05). The proposed quantification tools for DPT were found to have a moderate-to-strong correlation with the score results, especially with AC-joint specific scores. RW type V injuries had a moderate correlation with clinical parameters (OA AC with ACJI: r = 0.44, p > 0.05 and OL AC with TF: r = -0.45, p > 0.05). Measuring the OL AC is a convenient way for quantifying DPT in modified Alexander views. It showed significant correlation with clinical scores, indicating the relevance of DPT in patients with AC-joint injury.

The life and death of Alexander Bogdanov, physician.

PubMed

Huestis, D W

1996-08-01

It was early in April in 1928 when the word went out in Moscow that Alexander Bogdanov had died. He was a controversial figure, an old Bolshevik who had left that party long before the 1917 revolution and never returned. All the same, he had had Lenin's respect as a scientist (as long as he stayed out of politics). More recently, he also had the support of the new party strong man, Stalin. Bogdanov opposed the growing despotism of the "dictatorship of the proletariat", under which slogan Communist autocracy was being developed. But he was respected as a tireless propagandist for the socialist cause, an enthusiastic teacher of the proletariat, and a writer of arcane science and philosophy. Bogdanov was held in such respect that Communist bigwigs spoke glowingly at the funeral, praising his intellect, courage, and dedication to science and humanity. They did not fail to point out that he had split with his one-time friend, Lenin, and had succumbed to ideological "errors". Indeed, he had powerful enemies in the early Soviet state. Bogdanov was a physician, economist, philosopher, natural scientist, writer of utopian science fiction, poet, teacher, politician (unsuccesful), lifelong revolutionary, forerunner of what we now call cybernetics and organizational science, and founder of the world's first institution devoted entirely to the field of blood transfusion. You could call him a Renaissance man. Although he clearly fitted the category of the late-nineteenth-century Russian intellectual revolutionary, Bogdanov differed from most of them in being no dilettante. More than just a theorist, he was an active scientist and physician. As a teacher, he firmly believed that education and indoctrination could alter people's ways of thinking and behaving, and that humanity could be perfected under socialism. Like many revolutionaries, Bogdanov tried to keep ahead of the Tsar's police by using a variety of pseudonyms, among them Riadavoy, Werner, Maximov, and Bogdanov. After

James Sowerby: meteorites and his meteoritic sword made for the Emperor of Russia, Alexander I, in 1814

PubMed Central

Henderson, Paul

2013-01-01

James Sowerby included meteorites in his publications of British and exotic natural history and so raised interest in their nature and origins at a time of much debate and involving the President of the Royal Society, Sir Joseph Banks. The celebrations over the defeat of France in 1814 prompted Sowerby to make a sword from the Cape of Good Hope iron meteorite to present to the Russian Emperor, Alexander I, at the time of his state visit to London in June 1814 and in recognition of his achievements in bringing peace to Europe. The story of its attempted presentation, its final reception and the following response, including publications, all helped to increase interest in meteorites and their properties. The rediscovery of the sword after a lengthy disappearance probably brings an unusual saga to a fitting close.

Increased dynamic regulation of postural tone through Alexander Technique training

PubMed Central

Cacciatore, TW; Gurfinkel, VS; Horak, FB; Cordo, PJ; Ames, KE

2010-01-01

Gurfinkel and colleagues (2006) recently found that healthy adults dynamically modulate postural muscle tone in the body axis during anti-gravity postural maintenance and that this modulation is inversely correlated with axial stiffness. Our objective in the present study was to investigate whether dynamic modulation of axial postural tone can change through training. We examined whether teachers of the Alexander Technique (AT), who undergo “long-term” (3-year) training, have greater modulation of axial postural tone than matched control subjects. In addition, we performed a longitudinal study on the effect of “short-term” (10-week) AT training on the axial postural tone of individuals with low back pain (LBP), since short term AT training has previously been shown to reduce LBP. Axial postural tone was quantified by measuring the resistance of the neck, trunk and hips to small (±10°), slow (1°/s) torsional rotation during stance. Modulation of tone was determined by the torsional resistance to rotation (peak-to-peak, phase-advance, and variability of torque) and axial muscle activity (EMG). Peak-to-peak torque was lower (~50%), while phase-advance and cycle-to-cycle variability were enhanced for AT teachers compared to matched control subjects at all levels of the axis. In addition, LBP subjects decreased trunk and hip stiffness following short-term AT training compared to a control intervention. While changes in static levels of postural tone may have contributed to the reduced stiffness observed with the AT, our results suggest that dynamic modulation of postural tone can be enhanced through long-term training in the AT, which may constitute an important direction for therapeutic intervention. PMID:21185100

The Neotropical tanyderid Araucoderus gloriosus (Alexander) (Diptera, Tanyderidae), with description of the egg, larva and pupa, redescription of adults, and notes on natural history.

PubMed

Madriz, R Isaí; Courtney, Gregory W

2016-08-30

Larvae, pupae and adults of Araucoderus gloriosus (Alexander) were collected during fieldwork in Chilean Patagonia, December 2013 and January 2014. Eggs were obtained from females that oviposited in captivity. Association of all life stages is based on co-occurrence and rearing of individual larvae to adults. A diagnosis for the genus and species is provided. Descriptions of the egg, larva and pupa and redescriptions of the male and female are completed. Eggs of A. gloriosus are the first described for Tanyderidae. Natural history characteristics for this species, including microhabitat, copulatory behavior and oviposition, are discussed.

76 FR 4720 - Renewal of Agency Information Collection for Homeliving Programs and School Closure and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

... Number 1076-0164, which expires on March 31, 2011. DATES: Interested persons are invited to submit... able to do so. III. Data OMB Control Number: 1076-0164. Title: Homeliving Programs and School Closure...

76 FR 17964 - Renewal of Agency Information Collection for Home-Living Programs and School Closure and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-31

... School Closure and Consolidation, currently authorized by OMB Control Number 1076-0164, to the Office of... do so. III. Data OMB Control Number: 1076-0164. Title: Home-living Programs and School Closure and...

Increased dynamic regulation of postural tone through Alexander Technique training.

PubMed

Cacciatore, T W; Gurfinkel, V S; Horak, F B; Cordo, P J; Ames, K E

2011-02-01

Gurfinkel and colleagues (2006) recently found that healthy adults dynamically modulate postural muscle tone in the body axis during anti-gravity postural maintenance and that this modulation is inversely correlated with axial stiffness. Our objective in the present study was to investigate whether dynamic modulation of axial postural tone can change through training. We examined whether teachers of the Alexander Technique (AT), who undergo "long-term" (3-year) training, have greater modulation of axial postural tone than matched control subjects. In addition, we performed a longitudinal study on the effect of "short-term" (10-week) AT training on the axial postural tone of individuals with low back pain (LBP), since short term AT training has previously been shown to reduce LBP. Axial postural tone was quantified by measuring the resistance of the neck, trunk and hips to small (±10°), slow (1°/s) torsional rotation during stance. Modulation of tone was determined by the torsional resistance to rotation (peak-to-peak, phase-advance, and variability of torque) and axial muscle activity (EMG). Peak-to-peak torque was lower (∼50%), while phase-advance and cycle-to-cycle variability were enhanced for AT teachers compared to matched control subjects at all levels of the axis. In addition, LBP subjects decreased trunk and hip stiffness following short-term AT training compared to a control intervention. While changes in static levels of postural tone may have contributed to the reduced stiffness observed with the AT, our results suggest that dynamic modulation of postural tone can be enhanced through long-term training in the AT, which may constitute an important direction for therapeutic intervention. Copyright © 2010 Elsevier B.V. All rights reserved.

Embodiment and Entangled Subjectivity: A Study of Robin Cook's Coma, Priscille Sibley's The Promise of Stardust and Alexander Beliaev's Professor Dowell's Head.

PubMed

Karmakar, Manali; Parui, Avishek

2018-03-22

The essay examines Robin Cook's (1977) Coma and Priscille Sibley's (2013) The Promise of Stardust that dramatize the reified and disposable status of the brain-dead patients who are classified as nonpersons. The essay argues that the man-machine entanglement as depicted in the novels constructs a deterritorialized and entangled form of subjectivity that intervenes in the dominant biomedical understanding of personhood and agency that we notionally associate with a conscious mind. The essay concludes its arguments by discussing Alexander Beliaev's (1925) Professor Dowell's Head which depicts human subjectivity as an essentially embodied and distributive phenomenon and interrogates the Cartesian mind body dualism embedded in the dominant biomedical narratives.

LLNL Scientist is Passionate About Targets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Butlin, Becky

With a lifelong passion for problem-solving and a love of production, Becky Butlin has helped lead the National Ignition Facility Target Fabrication Team through obstacles and challenges for the past six years.

Obituary: Donald Alexander Macrae, 1916-2006

NASA Astrophysics Data System (ADS)

Seaquist, E. R.

2007-12-01

With the passing of Donald Alexander MacRae on 6 December 2006 at age 90, the astronomy community lost a visionary scientist and a great educator in the field. Don MacRae was born in Halifax, Nova Scotia, on 19 February 1916, to Donald Alexander and Laura Geddes (Barnstead) MacRae. His father was originally a classics scholar and preceptor of Greek and Latin at Princeton, but at the time of Don's birth in 1916 he was Dean of the Dalhousie Law School in Halifax. The family moved to Toronto, Ontario, in 1924 when his father joined the faculty of Osgoode Hall Law School in Toronto as a Professor of Law. After the family moved to Toronto, where he received most of his early education, he obtained his undergraduate degree in Mathematics and Physics in 1937 from the University of Toronto (U of T). He obtained the degree of A.M. in 1940 and of Ph.D. in 1943 from Harvard University under the mentorship of Bart Bok in the field of galactic structure. During his early career he worked briefly at the University of Pennsylvania, Cornell University, and Carbide and Chemical Corporation at Oak Ridge, Tennessee. For Don the latter work was a brief and somewhat uneasy association with the Manhattan Project. In 1946, he obtained a position at Case Institute of Technology (now Case Western Reserve University), where he worked until 1953. In 1953, he accepted a position at the U of T, replacing Ralph Williamson, who had earlier introduced Don to the emerging field of radio astronomy while they both were at Cornell. Don's primary research field was stellar spectroscopy, but his interests were much broader than this, and he possessed an abiding ability to interest students and faculty in new and emerging ideas. In the early 1960s he developed a strong interest in the nature and origin of the lunar surface, and discussed these extensively with colleagues. Many of his ideas on this subject were later confirmed by the lunar exploration program. Don's continuing interest in radio astronomy

Aberrant astrocyte Ca2+ signals "AxCa signals" exacerbate pathological alterations in an Alexander disease model.

PubMed

Saito, Kozo; Shigetomi, Eiji; Yasuda, Rei; Sato, Ryuichi; Nakano, Masakazu; Tashiro, Kei; Tanaka, Kenji F; Ikenaka, Kazuhiro; Mikoshiba, Katsuhiko; Mizuta, Ikuko; Yoshida, Tomokatsu; Nakagawa, Masanori; Mizuno, Toshiki; Koizumi, Schuichi

2018-05-01

Alexander disease (AxD) is a rare neurodegenerative disorder caused by gain of function mutations in the glial fibrillary acidic protein (GFAP) gene. Accumulation of GFAP proteins and formation of Rosenthal fibers (RFs) in astrocytes are hallmarks of AxD. However, malfunction of astrocytes in the AxD brain is poorly understood. Here, we show aberrant Ca 2+ responses in astrocytes as playing a causative role in AxD. Transcriptome analysis of astrocytes from a model of AxD showed age-dependent upregulation of GFAP, several markers for neurotoxic reactive astrocytes, and downregulation of Ca 2+ homeostasis molecules. In situ AxD model astrocytes produced aberrant extra-large Ca 2+ signals "AxCa signals", which increased with age, correlated with GFAP upregulation, and were dependent on stored Ca 2+ . Inhibition of AxCa signals by deletion of inositol 1,4,5-trisphosphate type 2 receptors (IP3R2) ameliorated AxD pathogenesis. Taken together, AxCa signals in the model astrocytes would contribute to AxD pathogenesis. © 2018 Wiley Periodicals, Inc.

The appearance of the artist to the people: the creativity, personality and malady of Alexander Ivanov (1806-58).

PubMed

Lerner, Vladimir; Witztum, Eliezer

2005-02-01

Alexander Ivanov was an outstanding Russian painter who lived in the middle of the nineteenth century, during the romantic period. He did not accept romanticism but instead tried to create his own original style, an ambitious combination of spiritual profundity and a manner of execution unparalleled in Western European art. Ivanov's intention and style are best reflected in his major work The Appearance of Christ to the People, a picture on which he worked for over 20 years. He painted more than 400 sketches of the picture while attempting to bring his masterpiece to perfection. At the end of his life Ivanov became disillusioned, renounced his strong religious conviction and became suspicious. This study examines the influence of his background, life story and personality on the creative process. From a diagnostic perspective, Ivanov's personality featured obsessive, narcissistic and schizoid traits. In his final years he suffered from a delusional disorder.

Alexander Scriabin: his chronic right-hand pain and Its impact on his piano compositions.

PubMed

Altenmüller, Eckart

2015-01-01

Alexander Scriabin was an outstanding pianist and an avant-garde composer who influenced later generations with his innovative "multimedia" conceptions of aesthetic experience. As an adolescent, he was systematically trained as a concert pianist and received lessons from Vassily Safonoff, one of the founders of the legendary Russian Piano School. At age 20, Scriabin suffered an overuse injury of his right hand when attempting to improve the sound quality of his piano touch. This injury caused a deep crisis and influenced his later composition style in his piano works. From this time on, his works were frequently dominated by unusual virtuosic use and wide spans of his left hand. Rest, restricted repertoire, and an increased focus on composition contributed to recovery; however, he always remained anxious concerning the stamina of his right hand. The case report impressively demonstrates the stressors an aspiring young pianist had to cope with at the end of the nineteenth century. Furthermore, it is a convincing example of how resource-oriented behavior and intuition lead to the improvement of health status. Differential diagnoses and the modern concept of multimodal pain therapy in chronic overuse injury will be discussed from a historical perspective. © 2015 Elsevier B.V. All rights reserved.

Dr. Alexander Garden, a Linnaean in colonial America, and the saga of five "electric eels".

PubMed

Finger, Stanley

2010-01-01

Alexander Garden (1730-1791) was born in Scotland, where he trained in medicine before settling in South Carolina in 1752. With a passion for collecting and a love of nature, he sent specimens to Linnaeus and his associates in Europe. In 1774, Garden observed and conducted electrical experiments on some "eels" that had survived the trip from Surinam to Charleston. His detailed observations and reasons for believing they emit electricity were read before the Royal Society of London and subsequently published. He also advised the sea captain who owned the eels on how to preserve them and where to deliver their bodies if they died en route to London. Although they did die en route, John Hunter of the Royal Society was able to provide excellent descriptions of their electric organs because they were so well preserved. The sequence of events that followed led to other live eels surviving the voyage to London, where they were observed to spark in darkness in 1776. This was a critical piece of evidence in favor of fish electricity and eventually for the more revolutionary idea that even human nerves and muscles might function electrically.

Obituary: Walter Alexander Feibelman, 1930-2004

NASA Astrophysics Data System (ADS)

Oergerle, William

2005-12-01

Walter Alexander Feibelman, 79, an astronomer who discovered the E-ring of Saturn, died of a heart attack 19 November 2004 at his home at Riderwood Village in Silver Spring, Maryland. Walter was born 30 October 1925 in Berlin, Germany to Bernard and Dora Feibelman. He came to the United States with his parents in 1941. They were some of the last German Jews to flee Nazi Germany. Years later, he reported his experiences in an account contributed to the U.S. Holocaust Memorial Museum. As a youth, he worked at a cleaning shop and as a soda jerk before taking a course in tool and die making. He worked at the Abbey Photo Corp. in New York and in a model-making firm, where he constructed models of aircraft for use in identification courses by the Army Air Forces. After high school, he attended the Carnegie Institute of Technology and received his BS degree in 1956. Until 1969, he was a research scientist at the University of Pittsburgh. While working as an assistant research professor in physics and astronomy at the University of Pittsburgh in 1967, he examined a photo of Saturn taken a year earlier at the university's Allegheny Observatory. The E-ring -- unlike the bright main rings, A, B, C, D and F -- is faint and not easily spotted. He paired his observation with calculations and announced his discovery, which remained unconfirmed until the Pioneer 11 flyby in 1979. Walter joined the Optical Astronomy Division of Goddard Space Flight Center in Greenbelt in 1969, and worked there until 2002, when he became an emeritus astronomer at NASA. He became associated with the International Ultraviolet Explorer project, and worked on developing detectors for the orbiting observatory's spectrograph. The project turned out to be one of NASA's most successful observatories, operating from 1978 to 1996. In his scientific career, he published more than 200 refereed articles, mainly on hot stars and planetary nebulae. He also wrote papers in the fields of photography, spectroscopy

ARC-1969-AC79-0164-2

NASA Image and Video Library

1979-02-05

Photo by Voyager 1 (JPL) Jupiter, its Great Red Spot and three of its four largest satellites are visible in this photo taken Feb 5, 1979 by Voyager 1. The spacecraft was 28.4 million kilomters (17.5 million miles) from the planet at the time. The inner-most large satellite, Io, can be seen against Jupiter's disk. Io is distinguished by its bright, brown-yellow surface. To the right of Jupiter is the satellite Europa, also very bright but with fainter surface markings. The darkest satellite, Callisto (still nearly twice as bright as Earth's Moon), is barely visible at the bottom left of the picture. Callisto shows a bright patch in its northern hemisphere. All tThree orbit Jupiter in the equatorial plane, and appear in their present position because Voyageris above the plane. All three satellites show the same face to Jupiter always -- just as Earth's Moon always shows us the same face. In this photo we see the sides of the satellites that always face away from the planet. Jupiter's colorfully banded atmosphere displays complex patterns highlighted by the Great Red Spot, a large, circulating atmospheric disturbance. This photo was assembled from three black and white negatives by the Image Processing Lab at Jet Propulsion Laboratory. JPL manages and controls the Voyage Project for NASA's Office of Space Science. (ref: P-21083)

ARC-1979-AC79-0164-1

NASA Image and Video Library

1979-02-13

Voyager 1 Image of Jupiter and two of its satellites (Io, left, and Europa). Io is about 350,000 kilometers (220,000 miles) above Jupiter's Great Red Spot; Europa is about 600,000 kilometers (375,000 miles) above Jupiter's clouds. Although both satellites have about the same brightness, Io's color is very different from Europa's. Io's equatorial region show two types of material -- dark orange, broken by several bright spots -- producing a mottled appearance. The poles are darker and reddish. Preliminary evidence suggests color variations within and between the polar regions. Io's surface composition is unknown, but scientists believe it may be a mixture of salts and sulfur. Erupoa is less strongly colored, although still relatively dark at short wavelengths. Markings on Eruopa are less evident that on the other satellites, although this picture shows darker regions toward the trailing half of the visible disk. Jupiter at this point is about 20 million kilometers (12.4 million miles) from the spacecraft. At this resolution (about 400 kimometers or 250 miles) there is evidence of circular motion in Jupiter's atmosphere. While the dominant large-scale motions are west-to-east, small-scale movement includes eddy-like circulation within and between the bands. (JPL ref: P-21082)

ARC-1979-A79-0164-1

NASA Image and Video Library

1979-02-13

Voyager 1 Image of Jupiter and two of its satellites (Io, left, and Europa). Io is about 350,000 kilometers (220,000 miles) above Jupiter's Great Red Spot; Europa is about 600,000 kilometers (375,000 miles) above Jupiter's clouds. Although both satellites have about the same brightness, Io's color is very different from Europa's. Io's equatorial region show two types of material -- dark orange, broken by several bright spots -- producing a mottled appearance. The poles are darker and reddish. Preliminary evidence suggests color variations within and between the polar regions. Io's surface composition is unknown, but scientists believe it may be a mixture of salts and sulfur. Erupoa is less strongly colored, although still relatively dark at short wavelengths. Markings on Eruopa are less evident that on the other satellites, although this picture shows darker regions toward the trailing half of the visible disk. Jupiter at this point is about 20 million kilometers (12.4 million miles) from the spacecraft. At this resolution (about 400 kimometers or 250 miles) there is evidence of circular motion in Jupiter's atmosphere. While the dominant large-scale motions are west-to-east, small-scale movement includes eddy-like circulation within and between the bands. (JPL ref: P-21082)

75 FR 54216 - CSX Transportation, Inc.-Abandonment Exemption―in Clay County, KY

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-03

...) North Ridge, milepost 0CF212; and (7) Becky Ann2, milepost 0CF217. The line traverses United States... should be sent to CSXT's representative: Kathryn R. Barney, CSX Transportation, Inc., 500 Water Street, J...

Identification of Ser-543 as the major regulatory phosphorylation site in spinach leaf nitrate reductase

NASA Technical Reports Server (NTRS)

Bachmann, M.; Shiraishi, N.; Campbell, W. H.; Yoo, B. C.; Harmon, A. C.; Huber, S. C.; Davies, E. (Principal Investigator)

1996-01-01

Spinach leaf NADH:nitrate reductase (NR) responds to light/dark signals and photosynthetic activity in part as a result of rapid regulation by reversible protein phosphorylation. We have identified the major regulatory phosphorylation site as Ser-543, which is located in the hinge 1 region connecting the cytochrome b domain with the molybdenum-pterin cofactor binding domain of NR, using recombinant NR fragments containing or lacking the phosphorylation site sequence. Studies with NR partial reactions indicated that the block in electron flow caused by phosphorylation also could be localized to the hinge 1 region. A synthetic peptide (NR6) based on the phosphorylation site sequence was phosphorylated readily by NR kinase (NRk) in vitro. NR6 kinase activity tracked the ATP-dependent inactivation of NR during several chromatographic steps and completely inhibited inactivation/phosphorylation of native NR in vitro. Two forms of NRk were resolved by using anion exchange chromatography. Studies with synthetic peptide analogs indicated that both forms of NRk had similar specificity determinants, requiring a basic residue at P-3 (i.e., three amino acids N-terminal to the phosphorylated serine) and a hydrophobic residue at P-5. Both forms are strictly calcium dependent but belong to distinct families of protein kinases because they are distinct immunochemically.

Improvement in automatic postural coordination following alexander technique lessons in a person with low back pain.

PubMed

Cacciatore, Timothy W; Horak, Fay B; Henry, Sharon M

2005-06-01

The relationship between abnormal postural coordination and back pain is unclear. The Alexander Technique (AT) aims to improve postural coordination by using conscious processes to alter automatic postural coordination and ongoing muscular activity, and it has been reported to reduce low back pain. This case report describes the use of the AT with a client with low back pain and the observed changes in automatic postural responses and back pain. The client was a 49-year-old woman with a 25-year history of left-sided, idiopathic, lumbrosacral back pain. Automatic postural coordination was measured using a force plate during horizontal platform translations and one-legged standing. The client was tested monthly for 4 months before AT lessons and for 3 months after lessons. Before lessons, she consistently had laterally asymmetric automatic postural responses to translations. After AT lessons, the magnitude and asymmetry of her responses and balance improved and her low back pain decreased. Further research is warranted to study whether AT lessons improve low back pain-associated abnormalities in automatic postural coordination and whether improving automatic postural coordination helps to reduce low back pain.

Post-traumatic stress reactions before the advent of post-traumatic stress disorder: potential effects on the lives and legacies of Alexander the Great, Captain James Cook, Emily Dickinson, and Florence Nightingale.

PubMed

Mackowiak, Philip A; Batten, Sonja V

2008-12-01

Evidence is presented that Alexander the Great, Captain James Cook, Emily Dickinson, and Florence Nightingale each developed symptoms consistent with post-traumatic stress disorder in the aftermath of repeated potentially traumatizing events of differing character. Their case histories also varied with respect to background, premorbid personality style, risk factors, clinical presentation, and course of the illness, illustrating the pleomorphic character of the disorder, as well as the special problems in diagnosing it in historical figures.

New insight into the thermal-tectonic history of the southern Antarctic Peninsula: (Uranium-Thorium-Samarium)/Helium and fission-track thermochronologic results from northwest Palmer Land and Alexander Island

NASA Astrophysics Data System (ADS)

Savrda, Amanda Marie

2011-12-01

This study examines the thermal history of the southern Antarctic Peninsula through the application of thermochronometry, and presents the first high-resolution thermochronologic dataset for arc rocks of northwest Palmer Land. I present 19 new thermochronologic ages obtained via (U-Th-Sm)/He and fission-track analyses of apatite and zircon from arc granitoids of northwest Palmer Land and fore-arc rocks of the LeMay and Fossil Bluff Groups of Alexander Island. These data were modeled via Monte Carlo simulations to generate time-temperature pathways. Thermal models generated for arc granitoids of northwest Palmer Land reveal a Late Cretaceous-Early Cenozoic episode of accelerated cooling from ca. 78--55 Ma not previously recognized in the southern Antarctic Peninsula. Here, faster cooling at an average rate of ˜15°C/Myr is bracketed by slower cooling at rates <3°C/Myr. Modeled thermal histories of metamorphosed fore-arc sedimentary rocks of Alexander Island reveal rapid cooling throughout the Eocene at an average rate of ˜13°C/Myr, preceded and followed by slower rates of cooling on the order of <3°C/Myr. The spatial and temporal distribution of the observed cooling trends may reflect localized variations in the thermal regime due to regional changes in plate kinematics, subduction dynamics, and related magmatism, but the cooling rates are also within range of those typical of exhumational processes such as normal faulting, ductile thinning, and erosion.

Semen quality before cryopreservation and after thawing in 543 patients with testicular cancer.

PubMed

MacKenna, Antonio; Crosby, Javier; Huidobro, Cristián; Correa, Eduardo; Duque, Gonzalo

2017-02-01

The main objective of this study was to assess semen characteristics of patients with testicular cancer before cryopreservation and after thawing, to evaluate the consequences of this technique on sperm quality in patients with testicular cancer. Five hundred eighty-nine samples from 543 patients with testicular cancer were cryopreserved between 1995 and 2015, one aliquot per patient was used for a thawing test to assess the impact of cryopreservation on sperm motility; semen analysis was performed before cryo preservation and after thawing, the result interpretation was carried out using the 2010 World Health Organization (WHO) Laboratory Manual, and consent forms were signed by the patients for freezing and when sperm was used for reproductive purposes. Hypospermia was observed in 28.7% of samples, the median sperm concentration was 18 million/mL with 35% oligozoospermia; twenty-two patients (4.1%) had azoospermia and 12.7% had severe oligozoospermia, the median sperm count was 31.3 million and 261 semen samples (44.3%) were normal in all parameters according to the WHO; total motile sperm count before cryopreservation and after thawing was 12 (0-412.2) and 7 (0-303.9) million sperm, respectively (p < 0.00001, 95% CI 5.48-14.91), which represents a 32% reduction; concerning the utilization of cryopreserved semen samples, only twelve patients (2.2%) used their frozen sperm for reproductive purposes. An impairment in semen quality was found in almost half of the samples from patients with testicular cancer, only few patients had azoospermia or severe oligozoospermia; sperm cryopreservation significantly reduces sperm motility and total motile sperm count and very few patients use their frozen sperm for reproductive purposes.

jsc2017e136942 - In the town of Baikonur, Kazakhstan, Expedition 54-55 backup crewmembers Jeanette Epps of NASA, Sergey Prokopyev of the Russian Federal Space Agency (Roscosmos) and Alexander Gerst of the European Space Agency lay flowers Dec. 6 at the sta

NASA Image and Video Library

2017-12-06

jsc2017e136942 - In the town of Baikonur, Kazakhstan, Expedition 54-55 backup crewmembers Jeanette Epps of NASA, Sergey Prokopyev of the Russian Federal Space Agency (Roscosmos) and Alexander Gerst of the European Space Agency lay flowers Dec. 6 at the sta

jsc2017e136944 - In the town of Baikonur, Kazakhstan, Expedition 54-55 backup crewmembers Jeanette Epps of NASA, Sergey Prokopyev of the Russian Federal Space Agency (Roscosmos) and Alexander Gerst of the European Space Agency lay flowers Dec. 6 at the sta

NASA Image and Video Library

2017-12-06

jsc2017e136944 - In the town of Baikonur, Kazakhstan, Expedition 54-55 backup crewmembers Jeanette Epps of NASA, Sergey Prokopyev of the Russian Federal Space Agency (Roscosmos) and Alexander Gerst of the European Space Agency lay flowers Dec. 6 at the sta

Samuel Alexander Kinnier Wilson. Wilson's disease, Queen Square and neurology.

PubMed

Broussolle, E; Trocello, J-M; Woimant, F; Lachaux, A; Quinn, N

2013-12-01

This historical article describes the life and work of the British physician Samuel Alexander Kinnier Wilson (1878-1937), who was one of the world's greatest neurologists of the first half of the 20th century. Early in his career, Wilson spent one year in Paris in 1903 where he learned from Pierre-Marie at Bicêtre Hospital. He subsequently retained uninterrupted links with French neurology. He also visited in Leipzig the German anatomist Paul Flechsig. In 1904, Wilson returned to London, where he worked for the rest of his life at the National Hospital for the Paralysed and Epileptic (later the National Hospital for Nervous Diseases, and today the National Hospital for Neurology and Neurosurgery) in Queen Square, and also at Kings' College Hospital. He wrote on 'the old motor system and the new', on disorders of motility and muscle tone, on the epilepsies, on aphasia, apraxia, tics, and pathologic laughing and crying, and most importantly on Wilson's disease. The other objective of our paper is to commemorate the centenary of Wilson's most important work published in 1912 in Brain, and also in Revue Neurologique, on an illness newly recognized and characterized by him entitled "Progressive lenticular degeneration, a familial nervous disease associated with liver cirrhosis". He analyzed 12 clinical cases, four of whom he followed himself, but also four cases previously published by others and a further two that he considered in retrospect had the same disease as he was describing. The pathological profile combined necrotic damage in the lenticular nuclei of the brain and hepatic cirrhosis. This major original work is summarized and discussed in the present paper. Wilson not only delineated what was later called hepato-lenticular degeneration and Wilson's disease, but also introduced for the first time the terms extrapyramidal syndrome and extrapyramidal system, stressing the role of the basal ganglia in motility. The present historical work emphasizes the special

Alexander von Humboldt: galvanism, animal electricity, and self-experimentation part 1: formative years, naturphilosophie, and galvanism.

PubMed

Finger, Stanley; Piccolino, Marco; Stahnisch, Frank W

2013-01-01

During the 1790s, Alexander von Humboldt (1769-1859), who showed an early interest in many facets of natural philosophy and natural history, delved into the controversial subject of galvanism and animal electricity, hoping to shed light on the basic nature of the nerve force. He was motivated by his broad worldview, the experiments of Luigi Galvani, who favored animal electricity in more than a few specialized fishes, and the thinking of Alessandro Volta, who accepted specialized fish electricity but was not willing to generalize to other animals, thinking Galvani's frog experiments flawed by his use of metals. Differing from many German Naturphilosophen, who shunned "violent" experiments, the newest instruments, and detailed measurement, Humboldt conducted thousands of galvanic experiments on animals and animal parts, as well as many on his own body, some of which caused him great pain. He interpreted his results as supporting some but not all of the claims made by both Galvani and Volta. Notably, because of certain negative findings and phenomenological differences, he remained skeptical about the intrinsic animal force being qualitatively identical to true electricity. Hence, he referred to a "galvanic force," not animal electricity, in his letters and publications, a theoretical position he would abandon with Volta's help early in the new century.

Methodology for the evaluation of the Stephanie Alexander Kitchen Garden program.

PubMed

Gibbs, L; Staiger, P K; Townsend, M; Macfarlane, S; Gold, L; Block, K; Johnson, B; Kulas, J; Waters, E

2013-04-01

Community and school cooking and gardening programs have recently increased internationally. However, despite promising indications, there is limited evidence of their effectiveness. This paper presents the evaluation framework and methods negotiated and developed to meet the information needs of all stakeholders for the Stephanie Alexander Kitchen Garden (SAKG) program, a combined cooking and gardening program implemented in selectively funded primary schools across Australia. The evaluation used multiple aligned theoretical frameworks and models, including a public health ecological approach, principles of effective health promotion and models of experiential learning. The evaluation is a non-randomised comparison of six schools receiving the program (intervention) and six comparison schools (all government-funded primary schools) in urban and rural areas of Victoria, Australia. A mixed-methods approach was used, relying on qualitative measures to understand changes in school cultures and the experiential impacts on children, families, teachers, parents and volunteers, and quantitative measures at baseline and 1 year follow up to provide supporting information regarding patterns of change. The evaluation study design addressed the limitations of many existing evaluation studies of cooking or garden programs. The multistrand approach to the mixed methodology maintained the rigour of the respective methods and provided an opportunity to explore complexity in the findings. Limited sensitivity of some of the quantitative measures was identified, as well as the potential for bias in the coding of the open-ended questions. The SAKG evaluation methodology will address the need for appropriate evaluation approaches for school-based kitchen garden programs. It demonstrates the feasibility of a meaningful, comprehensive evaluation of school-based programs and also demonstrates the central role qualitative methods can have in a mixed-method evaluation. So what? This paper

FIELD VALIDATION OF A SHEEPSHEAD MINNOW ESTROGEN-RESPONSIVE CDNA MACROARRAY

EPA Science Inventory

Hemmer, Michael J., Iris Knoebl, Becky L. Hemmer, Patrick Larkin, Peggy S. Harris and Nancy D. Denslow. In press. Field Validation of a Sheepshead Minnow Estrogen-Responsive cDNA Macroarray (Abstract). To be presented at the SETAC Fourth World Congress, 14-18 November 2004, Portl...

Semen quality before cryopreservation and after thawing in 543 patients with testicular cancer

PubMed Central

MacKenna, Antonio; Crosby, Javier; Huidobro, Cristián; Correa, Eduardo; Duque, Gonzalo

2017-01-01

Objective The main objective of this study was to assess semen characteristics of patients with testicular cancer before cryopreservation and after thawing, to evaluate the consequences of this technique on sperm quality in patients with testicular cancer. Methods Five hundred eighty-nine samples from 543 patients with testicular cancer were cryopreserved between 1995 and 2015, one aliquot per patient was used for a thawing test to assess the impact of cryopreservation on sperm motility; semen analysis was performed before cryo preservation and after thawing, the result interpretation was carried out using the 2010 World Health Organization (WHO) Laboratory Manual, and consent forms were signed by the patients for freezing and when sperm was used for reproductive purposes. Results Hypospermia was observed in 28.7% of samples, the median sperm concentration was 18 million/mL with 35% oligozoospermia; twenty-two patients (4.1%) had azoospermia and 12.7% had severe oligozoospermia, the median sperm count was 31.3 million and 261 semen samples (44.3%) were normal in all parameters according to the WHO; total motile sperm count before cryopreservation and after thawing was 12 (0-412.2) and 7 (0-303.9) million sperm, respectively (p < 0.00001, 95% CI 5.48-14.91), which represents a 32% reduction; concerning the utilization of cryopreserved semen samples, only twelve patients (2.2%) used their frozen sperm for reproductive purposes. Conclusions An impairment in semen quality was found in almost half of the samples from patients with testicular cancer, only few patients had azoospermia or severe oligozoospermia; sperm cryopreservation significantly reduces sperm motility and total motile sperm count and very few patients use their frozen sperm for reproductive purposes. PMID:28333030

NOAA Photo Library - Meet the Photographers/Becky Dayhuff

Science.gov Websites

spent most of her adult life writing, volunteering, and working on environmental and animal protection , including slide programs of her wildlife photography from Africa, to thousands of school children and civic worked with low income children. While her lesson plans emphasized the importance of reading, writing

Gender-Role Orientation of Female Cadets at the United States Air Force Academy

DTIC Science & Technology

1993-06-01

Becky"JJL •l, dhalr Professor Assistant Professor Counseling and Counseling and Counseling Psychology Counseling Psychology Debra C. Cobia Norman J... Cobia for their constructive criticism and support. Thanks are also due to Dr. Elizabeth Brazelton for he. assistance with the statistics and to Mary

Quantitative Evaluation of Brain Stem Atrophy Using Magnetic Resonance Imaging in Adult Patients with Alexander Disease.

PubMed

Yoshida, Tomokatsu; Yasuda, Rei; Mizuta, Ikuko; Nakagawa, Masanori; Mizuno, Toshiki

2017-01-01

Brain MRI in adult patients with Alexander disease (AxD) mainly shows atrophy in the medulla oblongata. However, currently there is no quantitative standard for assessing this atrophy. In this study, we quantitatively evaluated the brain stem of AxD patients with glial fibrillary acidic protein (GFAP) mutation using conventional MRI to evaluate its usefulness as an aid to diagnosing AxD in daily clinical practice. Nineteen AxD patients with GFAP mutation were compared with 14 patients negative for GFAP mutation in whom AxD was suspected due to "atrophy of the medulla oblongata." In the GFAP mutation-positive group, the sagittal diameter of the medulla oblongata, the ratio of the diameter of the medulla oblongata to that of the midbrain (MO/MB), and the ratio of the sagittal diameter of the medulla oblongata to that of the pons (MO/Po) were significantly smaller compared to those of the GFAP mutation-negative group (p < 0.01). The sensitivity and specificity of each parameter were 87.5 and 92.3%, 91.7 and 81.3%, and 88.2 and 100% with a sagittal diameter of the medulla oblongata <9.0 mm, MO/MB <0.60, and sagittal MO/Po <0.46, respectively. These parameters can provide very useful information to differentially diagnose AxD from other disorders associated with brain stem atrophy in adult patients. © 2017 S. Karger AG, Basel.

Language Acquisition in a Child with Cornelia De Lange Syndrome.

ERIC Educational Resources Information Center

Goodban, Marjorie T.

The paper describes a successful attempt to stimulate expressive language in Becky, a young child with Cornelia de Lange syndrome, a condition characterized by moderate to severe mental retardation, dwarfed stature, and excessive body hair. The child participated in infant stimulation and individual speech therapy and her expressive output has…

[Researchers training in the context of the collaborative projects: experiences of Instituto de Medicina Tropical "Alexander von Humbolt", Universidad Peruana Cayetano Heredia].

PubMed

Gotuzzo, Eduardo; González, Elsa; Verdonck, Kristien

2010-09-01

Research is a main element for human and social development. Under this point of view, it involves particular challenges and opportunities for the so-called "developing countries". An approach for those challenges and opportunities comes from the analysis of two interrelated activities; the training of new researchers and the research development with institutions or researchers which are external to the institution ("collaborative research"). Both activities are essential for the consolidation, widening and updating of the institutional capabilities for scientific production. We present here the experiences of the Instituto de Medicina Tropical "Alexander von Humboldt" of the Universidad Peruana Cayetano Heredia, in relation to the training of new researchers, we discuss the four elements we consider key for this process; the promotion of stimulating environments for research, the proactive identification of fellows, the complementary advice and networks consolidation; and we analyze three successful models of international collaboration for the training of new researchers under different institutional approaches.

Project Alexander the Great: a study on the world proliferation of bioengineering/biomedical engineering education.

PubMed

Abu-Faraj, Ziad O

2008-01-01

Bioengineering/Biomedical Engineering is considered amongst the most reputable fields within the global arena, and will likely be the primer for any future breakthroughs in Medicine and Biology. Bioengineering/biomedical engineering education has evolved since late 1950s and is undergoing advancement in leading academic institutions worldwide. This paper delineates an original study on the world proliferation of bioengineering/biomedical engineering education and bears the name 'Project Alexander the Great'. The initial step of the project was to survey all 10448 universities, recognized by the International Association of Universities, spread among the 193 member states of the United Nations within the six continents. The project aims at identifying, disseminating, and networking, through the world-wide-web, those institutions of higher learning that provide bioengineering/biomedical engineering education. The significance of this project is multifold: i) the inception of a web-based 'world-map' in bioengineering/biomedical engineering education for the potential international student desiring to pursue a career in this field; ii) the global networking of bioengineering/biomedical engineering academic/research programs; iii) the promotion of first-class bioengineering/biomedical engineering education and the catalysis of global proliferation of this field; iv) the erection of bridges among educational institutions, industry, and professional societies or organizations involved in Bioengineering/Biomedical Engineering; and v) the catalysis in the establishment of framework agreements for cooperation among the identified institutions offering curricula in this field. This paper presents the results obtained from Africa and North America. The whole project is due to be completed by 2009.

"Before I Realised They Were All Women… I Expected It to Be More about Materials": Art, Gender and Tacit Subjectivity

ERIC Educational Resources Information Center

Hames, Hannah

2016-01-01

This article discusses a critical discourse analysis research activity undertaken with a group of undergraduate primary trainees with an art specialism. The research activity involved the use of two contrasting texts discussing the work of Karla Black, Becky Beasley and Claire Barclay. The article explores how the positioning of the two texts…

Alexander Technique Training Coupled With an Integrative Model of Behavioral Prediction in Teachers With Low Back Pain.

PubMed

Kamalikhah, Tahereh; Morowatisharifabad, Mohammad Ali; Rezaei-Moghaddam, Farid; Ghasemi, Mohammad; Gholami-Fesharaki, Mohammad; Goklani, Salma

2016-09-01

Individuals suffering from chronic low back pain (CLBP) experience major physical, social, and occupational disruptions. Strong evidence confirms the effectiveness of Alexander technique (AT) training for CLBP. The present study applied an integrative model (IM) of behavioral prediction for improvement of AT training. This was a quasi-experimental study of female teachers with nonspecific LBP in southern Tehran in 2014. Group A contained 42 subjects and group B had 35 subjects. In group A, AT lessons were designed based on IM constructs, while in group B, AT lessons only were taught. The validity and reliability of the AT questionnaire were confirmed using content validity (CVR 0.91, CVI 0.96) and Cronbach's α (0.80). The IM constructs of both groups were measured after the completion of training. Statistical analysis used independent and paired samples t-tests and the univariate generalized linear model (GLM). Significant differences were recorded before and after intervention (P < 0.001) for the model constructs of intention, perceived risk, direct attitude, behavioral beliefs, and knowledge in both groups. Direct attitude and behavioral beliefs in group A were higher than in group B after the intervention (P < 0.03). The educational framework provided by IM for AT training improved attitude and behavioral beliefs that can facilitate the adoption of AT behavior and decreased CLBP.

Dynamics of mutated GFAP aggregates revealed by real-time imaging of an astrocyte model of Alexander disease.

PubMed

Mignot, Cyril; Delarasse, Cécile; Escaich, Séverine; Della Gaspera, Bruno; Noé, Eric; Colucci-Guyon, Emma; Babinet, Charles; Pekny, Milos; Vicart, Patrick; Boespflug-Tanguy, Odile; Dautigny, André; Rodriguez, Diana; Pham-Dinh, Danielle

2007-08-01

Alexander disease (AxD) is a rare neurodegenerative disorder characterized by large cytoplasmic aggregates in astrocytes and myelin abnormalities and caused by dominant mutations in the gene encoding glial fibrillary acidic protein (GFAP), the main intermediate filament protein in astrocytes. We tested the effects of three mutations (R236H, R76H and L232P) associated with AxD in cells transiently expressing mutated GFAP fused to green fluorescent protein (GFP). Mutated GFAP-GFP expressed in astrocytes formed networks or aggregates similar to those found in the brains of patients with the disease. Time-lapse recordings of living astrocytes showed that aggregates of mutated GFAP-GFP may either disappear, associated with cell survival, or coalesce in a huge juxtanuclear structure associated with cell death. Immunolabeling of fixed cells suggested that this gathering of aggregates forms an aggresome-like structure. Proteasome inhibition and immunoprecipitation assays revealed mutated GFAP-GFP ubiquitination, suggesting a role of the ubiquitin-proteasome system in the disaggregation process. In astrocytes from wild-type-, GFAP-, and vimentin-deficient mice, mutated GFAP-GFP aggregated or formed a network, depending on qualitative and quantitative interactions with normal intermediate filament partners. Particularly, vimentin displayed an anti-aggregation effect on mutated GFAP. Our data indicate a dynamic and reversible aggregation of mutated GFAP, suggesting that therapeutic approaches may be possible.

Growing community: the impact of the Stephanie Alexander Kitchen Garden Program on the social and learning environment in primary schools.

PubMed

Block, Karen; Gibbs, Lisa; Staiger, Petra K; Gold, Lisa; Johnson, Britt; Macfarlane, Susie; Long, Caroline; Townsend, Mardie

2012-08-01

This article presents results from a mixed-method evaluation of a structured cooking and gardening program in Australian primary schools, focusing on program impacts on the social and learning environment of the school. In particular, we address the Stephanie Alexander Kitchen Garden Program objective of providing a pleasurable experience that has a positive impact on student engagement, social connections, and confidence within and beyond the school gates. Primary evidence for the research question came from qualitative data collected from students, parents, teachers, volunteers, school principals, and specialist staff through interviews, focus groups, and participant observations. This was supported by analyses of quantitative data on child quality of life, cooperative behaviors, teacher perceptions of the school environment, and school-level educational outcome and absenteeism data. Results showed that some of the program attributes valued most highly by study participants included increased student engagement and confidence, opportunities for experiential and integrated learning, teamwork, building social skills, and connections and links between schools and their communities. In this analysis, quantitative findings failed to support findings from the primary analysis. Limitations as well as benefits of a mixed-methods approach to evaluation of complex community interventions are discussed.

Death by polonium-210: lessons learned from the murder of former Soviet spy Alexander Litvinenko.

PubMed

McFee, Robin B; Leikin, Jerrold B

2009-02-01

The medical response to radiation--whether the result of radiological warfare, terrorist deployment of improvised radiation dispersal weapons, political assassination, occupational or industrial accidents or the medically radiated patient remains one of the least taught among all disciplines within medical education. In the aftermath of 9/11 among medical vulnerabilities to toxicant threats, of all the categories of weapons of mass destruction (WMD)--whether using the CBRNE (chemical, biological, radiological, nuclear, explosive) or NBC (nuclear, biological, chemical) acronym--radiation is the least taught in professional schools, responder cultures or civil preparedness organizations. To date, few health care professionals (HCP) possess the fundamental knowledge or skills to identify and diagnose, let alone treat a radiation victim; this vulnerability made even more obvious in the aftermath of the high profile assassination of former Russian agent Alexander Litvinenko. He was poisoned with Polonium210. Radioactive substances are ubiquitous with radiation sources being in or transported through virtually every region nationwide. It is essential to increase preparedness among community and rural health care facilities as well as urban and university hospitals. Managing radiation injuries effectively requires access to specialized equipment and expertise. Radiation sickness is progressive and may require acute, critical and long-term care throughout the course of illness. Regardless of the source, preparedness rests upon acknowledging a threat exists and dedicating the resources to address the risks including the enhancement of training and equipment. Mass or individual exposures to radiation present unique challenges to the entire response continuum from law enforcement, first responders and emergency medical care. Increased education about and practice in responding to radiological threats is essential to enhance preparedness.

Bioenvironmental Engineering Career Ladder AFSC 907X0

DTIC Science & Technology

1991-05-01

TTA 1 1 HQ USAF/DPPE 1 HQ USAF/SGPA ( BOLLING AFB DC 20332-6188) 1 1 HQ USAFE/DPAT 3 3 HQ USAFE/TTA 1 1 HSD/SOSP 1 1 NODAC 1 USAFOMS/OMDQ 1 USAFOMS...this report are available for use by operations and training officials. Mr Roberto Salinas developed the survey instrument, Ms Becky Hernandez provided

A Lesson in the Meaning of Independence

ERIC Educational Resources Information Center

Kelly, Patricia K.

2003-01-01

After receiving word that a former client had recently passed away, the author reflects on the special time she had spent with her. The client's name was "Beckie"--the author's first set of contacts with her were quite ordinary. As the rehabilitation teacher (RT) serving that territory for the Maine Center for the Blind and Visually Impaired, the…

SAAB Tackling the Black, Brown Male Crisis

ERIC Educational Resources Information Center

Pluviose, David

2007-01-01

Increasingly, dropping out of high school is a one-way ticket to prison for Black men. Recent research conducted by sociologists Becky Pettit and Bruce Western indicates that 3 percent of Whites and 20 percent of Blacks born between 1965 and 1969 had served time in prison by their early thirties. The crisis among Black and Hispanic men mobilized…

Coherent Risk-Adjusted Decisions Over Time: a Bilevel Programming Approach

DTIC Science & Technology

2015-03-23

AFRL-AFOSR-VA-TR-2015-0310 Coherent Risk-Adjusted Decisions Over Time: a Bilevel Programming Approach Jonathan Eckstein RUTGERS THE STATE UNIVERSITY...FA9550-11-1-0164 5b. GRANT NUMBER FA9550-11-1-0164 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Eckstein, Jonathan Ruszczynski, Andrzej 5d. PROJECT... Jonathan Eckstein a. REPORT U b. ABSTRACT U c. THIS PAGE U 19b. TELEPHONE NUMBER (Include area code) 848-445-0510 Standard Form 298 (Rev. 8/98

Pesticide load dynamics during stormwater flow events in Mediterranean coastal streams: Alexander stream case study.

PubMed

Topaz, Tom; Egozi, Roey; Eshel, Gil; Chefetz, Benny

2018-06-01

Cultivated land is a major source of pesticides, which are transported with the runoff water and eroded soil during rainfall events and pollute riverine and estuarine environments. Common ecotoxicological assessments of riverine systems are mainly based on water sampling and analysis of only the dissolved phase, and address a single pesticide's toxicological impact under laboratory conditions. A clear overview of mixtures of pesticides in the adsorbed and dissolved phases is missing, and therefore the full ecotoxicological impact is not fully addressed. The aim of this study was to characterize and quantify pesticide concentrations in both suspended sediment and dissolved phases, to provide a better understanding of pesticide-load dynamics during storm events in coastal streams in a Mediterranean climate. High-resolution sampling campaigns of seven flood events were conducted during two rainy seasons in Alexander stream, Israel. Samples of suspended sediments were separated from the solution and both media were analyzed separately for 250 pesticides. A total of 63 pesticides were detected; 18 and 16 pesticides were found solely in the suspended sediments and solution, respectively. Significant differences were observed among the pesticide groups: only 7% of herbicide, 20% of fungicide and 42% of insecticide load was transported with the suspended sediments. However, in both dissolved and adsorbed phases, a mix of pesticides was found which were graded from "mobile" to "non-mobile" with varied distribution coefficients. Diuron, and tebuconazole were frequently found in large quantities in both phases. Whereas insecticide and fungicide transport is likely governed by application time and method, the governing factor for herbicide load was the magnitude of the stream discharge. The results show a complex dynamic of pesticide load affected by excessive use of pesticides, which should be taken into consideration when designing projects to monitor riverine and estuarine

Geosciences Information for Teachers (GIFT) Workshops held in Conjunction with Alexander von Humboldt (AvH) EGU Conferences

NASA Astrophysics Data System (ADS)

Laj, Carlo; Cifelli, Francesca

2015-04-01

The Alexander von Humboldt Conference Series of the European Geosciences Union are a series of meetings held outside of Europe, in particular in South America, Africa or Asia, on selected topics of geosciences with a socio-economic impact for regions on these continents, jointly organised with the scientists and their institutes and the institutions of these regions. Given the increasing success of the GIFT workshops held in conjunction with the General Assemblies, since 2010 EGU has also developed a series of GIFT workshops held in conjunction with AvH conferences. Associated GIFT workshops were held in Merida, Yucatan, on the theme of Climate Change, Natural Hazards and Societies (March 2010), then in Penang, Malaysia (June 2011) on the theme of Ocean Acidification, in November 2012 in Cusco (Peru) on the theme of Natural Disasters, Global Change and the Preservation of World Heritage Sites, finally in Istanbul (March 2014) on "High Impact Natural Hazards Related to the Euro-Mediterranean Region. The next GIFT workshop is already planned for October 2015 in Adis Ababa (Ethiopia) on the theme "Water". In each case, the GIFT workshop was held on the last two days of the AvH conference and reunited 40-45 teachers from the nation where the AvH was held. Keynote speakers from AvH were speakers to the GIFT workshops which also included hands-on activities animated by sciences educators. These GIFT workshops represented the first workshops specifically aimed at teachers held in the country, and therefore represents a significant Earth Sciences contribution to secondary education in non European countries.

A Fatigue Management System for Sustained Military Operations

DTIC Science & Technology

2008-03-31

Bradford, Brenda Jones, Margaret Campbell, Heather McCrory, Amy Campbell, Linda Mendez, Juan Cardenas, Beckie Moise, Samuel Cardenas, Fernando...always under the direct observation of research personnel or knowingly monitored from a central control station by closed circuit television, excluding...blocks 1, 5, 9, and 13). Statistical Analyses To determine the appropriate sample size for this study, a power analysis was based on the post

Geosciences Information for Teachers (GIFT) Workshops held in Conjunction with Alexander von Humboldt (AvH) EGU Conferences.

NASA Astrophysics Data System (ADS)

Laj, C. E.; Cifelli, F.

2014-12-01

Given the increasing success of the GIFT workshops held in conjunction with the General Assemblies, since 2010 EGU has also developed a series of GIFT workshops held in conjunction with AvH conferences. The Alexander von Humboldt Conference Series of the European Geosciences Union are a series of meetings held outside of Europe, in particular in South America, Africa or Asia, on selected topics of geosciences with a socio-economic impact for regions on these continents, jointly organised with the scientists and their institutes and the institutions of these regions. Associated GIFT workshops were held in Merida, Yucatan, on the theme of Climate Change, Natural Hazards and Societies (March 2010), then in Penang, Malaysia (June 2011) on the theme of Ocean Acidification, in November 2012 in Cusco (Peru) on the theme of Natural Disasters, Global Change and the Preservation of World Heritage Sites, finally in Istanbul (March 2014) on "High Impact Natural Hazards Related to the Euro-Mediterranean Region. The next GIFT workshop is already planned for October 2015 in Adis Ababa (Ethiopia) on the theme "Water". In each case, the GIFT workshop was held on the last two days of the AvH conference and reunited 40-45 teachers from the nation where the AvH was held. Keynote speakers from AvH were speakers to the GIFT workshops which also included hands-on activities animated by sciences educators. In 3 cases of the 4 cases, these GIFT workshops represented the first workshop specifically aimed at teachers held in the country, and therefore represents a significant Earth Sciences contribution to secondary education in non European countries.

The question of sign-language and the utility of signs in the instruction of the deaf: two papers by Alexander Graham Bell (1898).

PubMed

Bell, Alexander Graham

2005-01-01

Alexander Graham Bell is often portrayed as either hero or villain of deaf individuals and the Deaf community. His writings, however, indicate that he was neither, and was not as clearly definite in his beliefs about language as is often supposed. The following two articles, reprinted from The Educator (1898), Vol. V, pp. 3-4 and pp. 38-44, capture Bell's thinking about sign language and its use in the classroom. Contrary to frequent claims, Bell does not demand "oral" training for all deaf children--even if he thinks it is the superior alternative--but does advocate for it for "the semi-deaf" and "the semi-mute." "In regard to the others," he writes, "I am not so sure." Although he clearly voices his support for oral methods and fingerspelling (the Rochester method) over sign language, Bell acknowledges the use and utility of signing in a carefully-crafted discussion that includes both linguistics and educational philosophy. In separating the language used at home from that in school and on the playground, Bell reveals a far more complex view of language learning by deaf children than he is often granted. (M. Marschark).

Novel Array-Based Target Identification for Synergistic Sensitization of Breast Cancer to Herceptin

DTIC Science & Technology

2010-05-01

Tatsuya Azum, Eileen Adamson, Ryan Alipio, Becky Pio, Frank Jones, Dan Mercola. Chip- on- chip analysis of mechanism of action of HER2 inhibition in...Munawar, Kutbuddin S. Doctor, Michael Birrer, Michael McClelland, Eileen Adamson, Dan Mercola. Egr1 regulates the coordinated expression of numerous...Kemal Korkmaz, Mashide Ohmichi, Eileen Adamson, Michael McClelland, Dan Mercola. Identification of genes bound and regulated by ATF2/c-Jun

Early Prediction of Lupus Nephritis Using Advanced Proteomics

DTIC Science & Technology

2009-06-01

We are working with our collaborators at the Applied Biotechnology Branch, A ir Force Research Lab, W right-Patterson Air Force Base, to accomplish...with systemic lupus erythematosus. Arthritis Rheum 2001;44:2350–7. 33. Zappitelli M, Duffy CM, Bernard C, Gupta IR . Evaluation of activity, chronicity...Children’s Hospital, Chicago, IL: Dr. Linda Wagner-Weiner (data collection); Becky Puplava (study coordinator). University of Okla- homa Health Sciences

Archaeological Investigations in the Upper Tombigbee Valley, Mississippi: Phase I. Volume 1.

DTIC Science & Technology

1983-01-01

6.10 Site 221T563: Selected c,ramics; Alexander Incised .............................. 6.90 6.91 6.11 Site 221T563: Selected ceramics: Alexander... Incised .............................. 6.92 6.93 6.12 Site 221T563: Selected ceramics: Alexander Incised .............................. 6.94 6.95 6.13 Site...221T563: Selected ceramics: Alexander Incised .............................. 6.96 6.9i 6.14 Site 221T563: Selected ceramics: Alexander Incised

Alexander Ya. Orolv - Well-Known Scientist and Recognized Organizer of Astronmoical Research. Little Known Facts of His Life

NASA Astrophysics Data System (ADS)

Yatskiv, Ya. S.; Vavilova, I. B.; Korsun', A. A.

Alexander Ya. Orlov is a well-known astronomer and geophysicist as well as a worldrecognized organizer of scientific research in Russia, the USSR, and Ukraine. Orlov has formulated his main scientific ideas during the Odesa's period of life. He studied a tidal deformation of the Earth and its polar motion using the gravity and latitude observations. He has proposed new defenitions of a mean pole and a mean latitude, as wel as a new method for determing the Earth pole coordinates. To the end of 1940-ties, the Orlov's scientific ideas were implemented and stimulated a development of a research field, which is now called as Astrogeodynamics or Space Geodynamics. Among the representatives of the Orlov's scientific school are about 20 Doctors of Sciences and more than 40 Candidates of Sciences, including the members of Academy of Sciences of Ukraine and other countries. Among them are N.Stoyko-Radilenko (France), J.Witkowski (Poland), V.Zhardetsky (Yugoslavia-Austria-USA), D.Pyaskovsky, Z.Aksent'eva, E.Lavrentieva, N.Popov, E.Fedorov and A.Korol in Ukraine. The deserved followers of the Orlov's scientific ideas were also I.Androsov, I.Dyukov, K.Mansurova, B.Novopashennyj, N.V.Zimmerman in Russia and M.Bursa (Chesh Republic), who worked with him, as well as his sons, A.A.Orlov and B.A. Orlov. The Orlov's life and scientific activity were fully described in many articles. For that reason in this paper we will focus on the little-known facts of the Orlov's scientific-organizational activity, for example, the Orlov's appointments as a director of observatories in Odesa, Poltava, m.Pip-Ivan, Pulkovo, and Kyiv; interesesting facts related to his membership in the Academies of Sciences of the USSR and Ukrainian SSR; organization of a large-scale program on the latitude observations and gravimetric survey. We describe briefly his life and his astrogeodynamic scientific school.

Alexander von Humboldt: galvanism, animal electricity, and self-experimentation part 2: the electric eel, animal electricity, and later years.

PubMed

Finger, Stanley; Piccolino, Marco; Stahnisch, Frank W

2013-01-01

After extensive experimentation during the 1790s, Alexander von Humboldt remained skeptical about "animal electricity" (and metallic electricity), writing instead about an ill-defined galvanic force. With his worldview and wishing to learn more, he studied electric eels in South America just as the new century began, again using his body as a scientific instrument in many of his experiments. As had been the case in the past and for many of the same reasons, some of his findings with the electric eel (and soon after, Italian torpedoes) seemed to argue against biological electricity. But he no longer used galvanic terminology when describing his electric fish experiments. The fact that he now wrote about animal electricity rather than a different "galvanic" force owed much to Alessandro Volta, who had come forth with his "pile" (battery) for multipling the physical and perceptable effects of otherwise weak electricity in 1800, while Humboldt was deep in South America. Humboldt probably read about and saw voltaic batteries in the United States in 1804, but the time he spent with Volta in 1805 was probably more significant in his conversion from a galvanic to an electrical framework for understanding nerve and muscle physiology. Although he did not continue his animal electricity research program after this time, Humboldt retained his worldview of a unified nature and continued to believe in intrinsic animal electricity. He also served as a patron to some of the most important figures in the new field of electrophysiology (e.g., Hermann Helmholtz and Emil du Bois-Reymond), helping to take the research that he had participated in to the next level.

Adult-onset Alexander disease, associated with a mutation in an alternative GFAP transcript, may be phenotypically modulated by a non-neutral HDAC6 variant.

PubMed

Melchionda, Laura; Fang, Mingyan; Wang, Hairong; Fugnanesi, Valeria; Morbin, Michela; Liu, Xuanzhu; Li, Wenyan; Ceccherini, Isabella; Farina, Laura; Savoiardo, Mario; D'Adamo, Pio; Zhang, Jianguo; Costa, Alfredo; Ravaglia, Sabrina; Ghezzi, Daniele; Zeviani, Massimo

2013-05-01

We studied a family including two half-siblings, sharing the same mother, affected by slowly progressive, adult-onset neurological syndromes. In spite of the diversity of the clinical features, characterized by a mild movement disorder with cognitive impairment in the elder patient, and severe motor-neuron disease (MND) in her half-brother, the brain Magnetic Resonance Imaging (MRI) features were compatible with adult-onset Alexander's disease (AOAD), suggesting different expression of the same, genetically determined, condition. Since mutations in the alpha isoform of glial fibrillary acidic protein, GFAP-α, the only cause so far known of AOAD, were excluded, we applied exome Next Generation Sequencing (NGS) to identify gene variants, which were then functionally validated by molecular characterization of recombinant and patient-derived cells. Exome-NGS revealed a mutation in a previously neglected GFAP isoform, GFAP-ϵ, which disrupts the GFAP-associated filamentous cytoskeletal meshwork of astrocytoma cells. To shed light on the different clinical features in the two patients, we sought for variants in other genes. The male patient had a mutation, absent in his half-sister, in X-linked histone deacetylase 6, a candidate MND susceptibility gene. Exome-NGS is an unbiased approach that not only helps identify new disease genes, but may also contribute to elucidate phenotypic expression.

Alexander Dalgarno

NASA Astrophysics Data System (ADS)

Fox, Jane L.

Alex Dalgarno saved my career. I entered the Graduate School at Harvard in the Chemistry Department in September of 1973 from the University of Michigan, where I had (unfortunately) majored in Chemistry. Chemistry is considered a "laboratory science" but I had no talent in the laboratory. I had merely fallen in love with the ideal gas law in high school, and I had stubbornly allowed this to determine my course of studies, most of which had nothing to do with the ideal gas law, and much of which was focused on laboratory studies...

Lineage fusion in Galápagos giant tortoises.

PubMed

Garrick, Ryan C; Benavides, Edgar; Russello, Michael A; Hyseni, Chaz; Edwards, Danielle L; Gibbs, James P; Tapia, Washington; Ciofi, Claudio; Caccone, Adalgisa

2014-11-01

Although many classic radiations on islands are thought to be the result of repeated lineage splitting, the role of past fusion is rarely known because during these events, purebreds are rapidly replaced by a swarm of admixed individuals. Here, we capture lineage fusion in action in a Galápagos giant tortoise species, Chelonoidis becki, from Wolf Volcano (Isabela Island). The long generation time of Galápagos tortoises and dense sampling (841 individuals) of genetic and demographic data were integral in detecting and characterizing this phenomenon. In C. becki, we identified two genetically distinct, morphologically cryptic lineages. Historical reconstructions show that they colonized Wolf Volcano from Santiago Island in two temporally separated events, the first estimated to have occurred ~199 000 years ago. Following arrival of the second wave of colonists, both lineages coexisted for approximately ~53 000 years. Within that time, they began fusing back together, as microsatellite data reveal widespread introgressive hybridization. Interestingly, greater mate selectivity seems to be exhibited by purebred females of one of the lineages. Forward-in-time simulations predict rapid extinction of the early arriving lineage. This study provides a rare example of reticulate evolution in action and underscores the power of population genetics for understanding the past, present and future consequences of evolutionary phenomena associated with lineage fusion. © 2014 John Wiley & Sons Ltd.

Public information needs after the poisoning of Alexander Litvinenko with polonium-210 in London: cross sectional telephone survey and qualitative analysis.

PubMed

Rubin, G James; Page, Lisa; Morgan, Oliver; Pinder, Richard J; Riley, Paul; Hatch, Stephani; Maguire, Helen; Catchpole, Mike; Simpson, John; Wessely, Simon

2007-12-01

To identify public perceptions of the risk to health after the poisoning of Alexander Litvinenko with polonium-210 (210Po) in London and to assess the impact of public health communications. Cross sectional telephone survey and qualitative interviews. London, United Kingdom. 1000 people completed the cross sectional survey and 86 potentially exposed people completed the qualitative interviews. Perception of risk to personal health after the 210Po incident. Qualitative interviews were analysed with an emphasis on information needs. 11.7% of the survey sample (n=117) perceived their health to be at risk. Aside from personal variables the main predictors of perceived risk to health were believing that the incident was related to terrorism (odds ratio 2.7, 95% confidence interval 1.5 to 4.6) rather than to espionage, that it was targeted at the wider public rather than one person (5.9, 3.2 to 10.9), and that it could affect people who had not been in the contaminated area (3.2, 2.1 to 5.1). Participants in the qualitative interviews were generally satisfied with the information they had received, although they would have preferred more information about their individual risk of exposure, the results of their urine tests, and the health implications of the incident. Perceptions of the public that the 210Po incident in London in 2006 was related to espionage helped to reassure them that the risks to personal health were low. In the event of future incidents it is important to ensure that detailed, comprehensible information about the risks of any exposure is available.

A Comparison of the Usefulness of the Facilities Management Program in the Graduate School of Systems and Logistics and Similar Programs in Civilian Institutions as Perceived by Former Students

DTIC Science & Technology

1980-06-01

8217 \\ PhlipM./Ray ap ta in, usA~Yj AUG 5 1980 IlkJ D DETTBIBUTION STATE?4ENT A Apprtvncl foT public TOIOO.B0 e e i hi U == I The contents off the...education in the context of course content and their programs are useful; the current FM program is current and relevant, however, it does need to be...dedi- cate this thesis to Judy and Becky. TABLE OF CONTENTS Page ACKNOWLEDGEMENTS .". . ..... ......... ......... ......... iii. LIST OF TABLES

Illustrated and online catalog of type specimens of freshwater fishes in the Colección de Peces Dulceacuícolas of Instituto de Investigación de Recursos Biológicos Alexander von Humboldt (IAvH-P), Colombia.

PubMed

Donascimiento, Carlos; Cárdenas-Bautista, Johann-Stephens; Acosta, Kevin Giancarlo Borja; González-Alvarado, Arturo; Medina, Claudia A

2016-09-29

The catalog of type specimens of freshwater fishes deposited in the Colección de Peces Dulceacuícolas del Instituto de Investigación de Recursos Biológicos Alexander von Humboldt (IAvH-P) is presented. This list includes 483 specimens in 65 lots representing 11 holotypes and 472 paratypes of 48 nominal species. Corrections, additions, and updating of information in the original descriptions are included in individual remarks for each catalog number entry and a gallery of pictures of holotypes or paratypes of each nominal species is also presented, which supplements some original descriptions lacking figures of their respective types. An online version of the catalog is available at http://humboldt.org.co/en/servicios/colecciones-biologicas/catalogo-de-tipos.

Report: EPA's Fiscal Year 2015 Management Challenges

EPA Pesticide Factsheets

Report #15-N-0164, May 28, 2015. Attention to agency management challenges could result in stronger results and protection for the public, and increased confidence in management integrity and accountability.

How our changing research arena can inspire innovative environmental research in developing countries (Alexander von Humboldt Medal Lecture)

NASA Astrophysics Data System (ADS)

Bouma, Johan

2017-04-01

Alexander von Humboldt was a true pioneer by engagingly articulating an ecosystem-wide vision on environmental issues and research, connecting and moving beyond disciplinary boundaries. Focusing here on soil science as an important discipline within the geosciences, the work of our group has acted in the spirit of this approach by focusing on interdisciplinary systems research in different developing countries in close interaction with stakeholders, based on soil processes in a dynamic landscape context. But recent developments of internet and social media are drastically changing relations between science and society all over the world. Scientists have to continuously struggle to keep their "societal license to research". Researchers in so-called developed countries would be well advised to communicate lessons learned to scientists in developing countries allowing them to leapfrog and avoid making time- consuming mistakes adhering to yesterday's practices. Specifically, attention should be paid to: (i) more continuing interaction with stakeholders when planning and executing research. This takes time that should be allocated in research projects. ; (ii) the quality of a limited number of key papers rather than on the total number of published and cited scientific papers, when judging researchers; (iii) defining new research on the basis of proven inadequacy of existing techniques and methods, realizing that "new" is not necessarily "better" and that available research methods and procedures can solve many current environmental problems; (iv) showing the value of the scientific approach that does not articulate: "yet another opinion" but is essential to face the major environmental challenges of the 21th century. (v) demonstrate the crucial importance of interdisciplinary ecosystem research and innovation when addressing the seventeen UN Sustainable Developments Goals (SDG's) that are attractive now as a focus for the scientific effort in land-related research. (vi

75 FR 3474 - National Institute of Environmental Health Sciences; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-21

...: Nat. Inst. of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander..., Rodbell Auditorium, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709. Closed: February 19, 2010... Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle...

78 FR 48695 - National Institute of Environmental Health Sciences; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-09

... Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC.... of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive..., Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709. Contact Person: Gwen W...

76 FR 6146 - National Institute of Environmental Health Sciences; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-03

...: National Institute of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T.W. Alexander... 101, Rodbell Auditorium, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709. Open: February 17... Institute of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T.W. Alexander Drive...

Public information needs after the poisoning of Alexander Litvinenko with polonium-210 in London: cross sectional telephone survey and qualitative analysis

PubMed Central

Page, Lisa; Morgan, Oliver; Pinder, Richard J; Riley, Paul; Hatch, Stephani; Maguire, Helen; Catchpole, Mike; Simpson, John; Wessely, Simon

2007-01-01

Objectives To identify public perceptions of the risk to health after the poisoning of Alexander Litvinenko with polonium-210 (210Po) in London and to assess the impact of public health communications. Design Cross sectional telephone survey and qualitative interviews. Setting London, United Kingdom. Participants 1000 people completed the cross sectional survey and 86 potentially exposed people completed the qualitative interviews. Main outcome measures Perception of risk to personal health after the 210Po incident. Qualitative interviews were analysed with an emphasis on information needs. Results 11.7% of the survey sample (n=117) perceived their health to be at risk. Aside from personal variables the main predictors of perceived risk to health were believing that the incident was related to terrorism (odds ratio 2.7, 95% confidence interval 1.5 to 4.6) rather than to espionage, that it was targeted at the wider public rather than one person (5.9, 3.2 to 10.9), and that it could affect people who had not been in the contaminated area (3.2, 2.1 to 5.1). Participants in the qualitative interviews were generally satisfied with the information they had received, although they would have preferred more information about their individual risk of exposure, the results of their urine tests, and the health implications of the incident. Conclusions Perceptions of the public that the 210Po incident in London in 2006 was related to espionage helped to reassure them that the risks to personal health were low. In the event of future incidents it is important to ensure that detailed, comprehensible information about the risks of any exposure is available. PMID:17975252

Report: Clean Air Act Facility Evaluations Are Conducted, but Inaccurate Data Hinder EPA Oversight and Public Awareness

EPA Pesticide Factsheets

Report #16-P-0164, May 3, 2016. Accurate enforcement databases and updated CMS plans promote effective and efficient EPA oversight of compliance programs, and help to protect the public from harmful air pollutants.

77 FR 60448 - National Institute of Environmental Health Sciences Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-03

... Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC..., Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709. Closed: November 5, 2012... Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709...

78 FR 59042 - National Institute of Environmental Health Sciences; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-25

...: Nat. Inst. of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander... Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709. Closed: October 21, 2013, 11:15 a.m... Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle...

jsc2017e136057 - On a snowy night at Red Square Moscow, Expedition 54-55 backup crewmembers Sergey Prokopyev of the Russian Federal Space Agency (Roscosmos, left), Jeanette Epps of NASA (center) and Alexander Gerst of the European Space Agency (right) pay

NASA Image and Video Library

2017-11-30

jsc2017e136057 - On a snowy night at Red Square Moscow, Expedition 54-55 backup crewmembers Sergey Prokopyev of the Russian Federal Space Agency (Roscosmos, left), Jeanette Epps of NASA (center) and Alexander Gerst of the European Space Agency (right) pay homage at the Kremlin Wall where Russian space icons are interred in traditional pre-launch ceremonies Nov. 30. They are backups to Anton Shkaplerov of Roscosmos, Scott Tingle of NASA and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA), who will launch from the Baikonur Cosmodrome in Kazakhstan on the Soyuz MS-07 spacecraft Dec. 17 for a five-month mission on the International Space Station...Andrey Shelepin/Gagarin Cosmonaut Training Center.

77 FR 39986 - Information Collection; Health Screening Questionnaire

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-06

... DEPARTMENT OF AGRICULTURE Forest Service Information Collection; Health Screening Questionnaire... organizations on the extension of a currently approved information collection, Health Screening Questionnaire... holidays. SUPPLEMENTARY INFORMATION: Title: Health Screening Questionnaire. OMB Number: 0596-0164...

76 FR 46823 - National Institute of Environmental Health Sciences; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-03

..., Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709. Closed: September 1, 2011... Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle... Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709. Contact Person: Gwen W Collman, PhD...

More Cases of Benign Testicular Teratomas are Detected in Adults than in Children. A Clinicopathological Study of 543 Testicular Germ Cell Tumor Cases.

PubMed

David, Semjén; András, Farkas; Endre, Kalman; Balint, Kaszas; Árpad, Kovács; Csaba, Pusztai; Karoly, Szuhai; Tamás, Tornóczky

2017-07-01

Benign testicular teratomas are always thought to be pediatric neoplasms and previously all the teratoid tumors in the adult testis regarded as malignant. Recently, three publications reported benign testicular teratomas in adulthood and the latest WHO classification refers them as "prepubertal type of teratomas" which rarely appear in adulthood. These neoplasms behave benign and seemingly analogous independently whether they appear in pre- or postpubertal patients. The aim of our study was to investigate the frequency of benign testicular teratomas both in children and adults. 593 cases of testicular neoplasms were found in a period of 17 years ranging from 1998 to 2014 in the archive of our department (Department of Pathology, Medical Center, Pécs University). 543 cases diagnosed as germ cell tumor which have all been further evaluated in conjunction with the clinical data available. Of all germ cell tumor cases 14 (2.5 %) were pure teratomas. Ten out of 14 were the WHO-defined "conventional" teratoma, 4 of the 14 were the "benign or the so called prepubertal type" from which three occurred in adult patients. Only one of the 14 occurred in childhood, indicating that benign prepubertal type teratomas -which are regarded generally as childhood tumors- are more frequently detected in adults than in children. Benign adult testicular teratomas comprised 21 % of all pure teratoma cases in our series. Practicioners in the field have to be aware of its existence also in adulthood to avoid overtreatment and not to expose their patients to unnecessary chemotherapy, retroperitoneal lymphadenectomy (RLA) and the potential complications of these interventions.

75 FR 57280 - National Institute of Environmental Health Sciences; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-20

..., Rodbell Auditorium, 111 T. W. Alexander Drive, Conference Rooms 101 A, B, and C, Research Triangle Park... Auditorium, 111 T. W. Alexander Drive, Conference Rooms 101 A, B, and C, Research Triangle Park, NC 27709... Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive, Conference Rooms 101...

Educational Psychology's Past and Future Contributions to the Science of Learning, Science of Instruction, and Science of Assessment

ERIC Educational Resources Information Center

Mayer, Richard E.

2018-01-01

Patricia Alexander (2018) provides a thought-provoking analysis of the past and future of educational psychology. Based on the themes in Alexander's paper, the present paper explores the past and future of educational psychology's contributions to: (a) the science of learning, corresponding to Alexander's theme of "a focus on learning as a…

Self-efficacy and embodiment associated with Alexander Technique lessons or with acupuncture sessions: A longitudinal qualitative sub-study within the ATLAS trial.

PubMed

Wenham, Aniela; Atkin, Karl; Woodman, Julia; Ballard, Kathleen; MacPherson, Hugh

2018-05-01

A large randomised controlled trial found that the provision of either Alexander Technique lessons or acupuncture, for those with chronic neck pain, resulted in significantly increased self-efficacy when compared with usual care alone. In turn, enhanced self-efficacy was associated with significant reductions in neck pain at 6 and 12 months. In this analysis we explore the perspectives of participants within the trial, with the aim of gaining a better understanding of how these interventions had an impact. We used a longitudinal qualitative approach; in-depth interviews, informed by a topic guide, were conducted with a sample of the trial population. Participants were interviewed twice: at around six months (n = 30) and twelve months (n = 26) after trial entry. Analysis was guided by the principles of grounded theory, and key themes were developed. Five key themes emerged: pre-trial experiences of biomedical treatment against which subsequent interventions were compared; emergence of tangible benefits from the interventions; factors that contributed to the observed benefits, notably growing self-care and self-efficacy; a developing sense of embodiment as an integral part of the transformative process; and contribution of these factors to sustaining benefits over the longer term. In-depth interviews revealed a rich array of experiences. They gave insight into the positive impact of the interventions on development of self-care, self-efficacy and embodiment. These findings complement the quantitative trial data, providing a more nuanced understanding of the factors that underpin the previously quantified improvement in self-efficacy and its association with longer-term reductions in pain. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

76 FR 60837 - Federal Acquisition Regulation; Information Collection; Contractor Business Ethics Compliance...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-30

...; Information Collection; Contractor Business Ethics Compliance Program and Disclosure Requirements AGENCIES... concerning contractor business ethics compliance program and disclosure requirements. Public comments are... Collection 9000- 0164, Contractor Business Ethics Compliance Program and Disclosure Requirements, by any of...

76 FR 74845 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-01

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2011-0164] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on...

77 FR 7659 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-13

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2011-0164] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on...

76 FR 37353 - Federal Acquisition Regulation; Submission for OMB Review; Contractor Business Ethics Compliance...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-27

...; Submission for OMB Review; Contractor Business Ethics Compliance Program and Disclosure Requirements AGENCIES... contractor business ethics compliance program and disclosure requirements. Public comments are particularly... Information Collection 9000- 0164, Contractor Business Ethics Compliance Program and Disclosure Requirements...

Rejoinder to Craig A. Cunningham, David Granger, Jane Fowler Morse, Barbara Stengel, and Terri Wilson, "Dewey, Women, and Weirdoes"

ERIC Educational Resources Information Center

Fitzgerald, Terry

2010-01-01

It is good to see Cunningham et al. including F. Matthias Alexander in their list of positive influences in John Dewey's life. However, I believe Cunningham's essay, "Shared explorations of body-mind: the reciprocal influences of Dewey and F.M. Alexander", falls short in its acknowledgement of Alexander and in one important aspect is incorrect. In…

[Gerda Alexander eutonia].

PubMed

Murcia, R

1991-01-01

One of the most important objectives of euronia is to find the adequate tonus in situations of total rest or of maximum dynamism. The dimension of tonic mastery together with relaxation make eutonia an extremely useful method in phoniatrics and orthophony.

Alexander A Friedmann

NASA Astrophysics Data System (ADS)

Tropp, Eduard A.; Frenkel, Viktor Ya.; Chernin, Artur D.; Dron, Alexander; Burov, Michael

2006-05-01

Preface; 1. The Friedmanns and the Vojaceks; 2. At the 2nd St Petersburg Gymnasium; 3. University years, 1906-14; 4. In search of a way; 5. War years; 6. Moscow - Perm - Petrograd; 7. Theoretical department of the Main Geophysical Observatory; 8. Space and time; 9. Geometry and dynamics of the Universe; 10. Petrograd, 1920-4; 11. The final year; 12. Friedmann's world; Conclusion; Main dates in Friedmann's life and work; Bibliography; Name Index.

An Arizona Border Wall Case Study

DTIC Science & Technology

2017-12-01

WALL CASE STUDY by Justin Alexander Bristow December 2017 Thesis Advisor: Erik Dahl Second Reader: Jorge Gonzalez THIS PAGE...4. TITLE AND SUBTITLE AN ARIZONA BORDER WALL CASE STUDY 5. FUNDING NUMBERS 6. AUTHOR(S) Justin Alexander Bristow 7. PERFORMING ORGANIZATION...PAGE INTENTIONALLY LEFT BLANK iii Approved for public release. Distribution is unlimited. AN ARIZONA BORDER WALL CASE STUDY Justin Alexander

Enhancement of the Daytime MODIS Based Aircraft Icing Potential Algorithm Using Mesoscale Model Data

DTIC Science & Technology

2006-03-01

January, 15, 2006 ...... 37 x Figure 25. ROC curves using 3 hour PIREPs and Alexander Tmap with symbols plotted at the 0.5 threshold values...42 Figure 26. ROC curves using 3 hour PIREPs and Alexander Tmap with symbols plotted at the 0.5 threshold values...Table 4. Results using T icing potential values from the Alexander Tmap , and 3 Hour PIREPs

At the Cosmonaut Hotel in Baikonur, Kazakhstan, Expedition 48-49 crewmembers Takuya Onishi of the Japan Aerospace Exploration Agency (left) and Anatoly Ivanishin of Roscosmos share a game of ping-pong June 30 during pre-launch activities. They and Kate Rubins of NASA will launch July 7, Baikonur time, on the Soyuz MS-01 spacecraft for a planned four-month mission on the International Space Station...NASA/Alexander Vysotsky.

NASA Image and Video Library

2016-06-30

At the Cosmonaut Hotel in Baikonur, Kazakhstan, Expedition 48-49 crewmembers Takuya Onishi of the Japan Aerospace Exploration Agency (left) and Anatoly Ivanishin of Roscosmos share a game of ping-pong June 30 during pre-launch activities. They and Kate Rubins of NASA will launch July 7, Baikonur time, on the Soyuz MS-01 spacecraft for a planned four-month mission on the International Space Station. NASA/Alexander Vysotsky

HISTORIA Alexandri Magni: Astronomy, Astrology and Tradition

NASA Astrophysics Data System (ADS)

Papathanassiou, M.

A popular text on the birth, life and death of Alexander the Great is that attributed to Pseudo-Callisthenes. According to this Byzantine text Alexander is the son of the last king of Egypt, the Pharao Nectanebo, who left his country and following Apollo's oracle visited Macedonia. Nectanebo was famous for his astronomical, astrological and magical knowledge which he used to prevent Alexander's birth for some hours until a favoured time comes. In only one manuscript (Paris. gr. 1711, 11th century) of this work there is a unique passage in which astronomical information is given regarding the positions of the Sun, the Moon, and the five planets at the time of Alexander's birth. In this paper I attempt a study of all information related to the astronomical instruments and their use as mentioned in the text as well as of the astronomical information regarding Alexander's birth.

[Improvement of hygiene and the combat of epidemics as Russian state concerns during World War I: Prince Alexander von Oldenburg and the POWs of the Central Powers in Russia].

PubMed

Nachtigal, Reinhard

2004-01-01

When Russia joined the war against the Central Powers in 1914, she immediately faced problems of public health care among the masses of people who were forced to move across far distances in the country: soldiers, refugees, and prisoners of war. Because of poor organisation and the unexpectedly long duration of the war, the POWs fared worst of all war victims in Russia. Subjected to an overstrained military organisation in the rear, the fate of this broadly neglected group illustrates how and with what success Russia strove to meet its deficiencies in administrative structure during wartime. The "Evacuation and Sanitation Section" was put under the command of a member of the Imperial family, Prince Alexander of Oldenburg, a high ranking official of German origin. This amateur scientist and initiator of medical institutions was an energetic and courageous personality who became vital for the fate of millions of POWs in epidemic-stricken Russia. The role of this "silent" ally of the German and Austro-Hungarian governments has hitherto been unknown. Newly found sources in Russian archives now shed an interesting light on a weak spot of Russia's administration and a generally neglected chapter of the history of medicine, the handling of epidemics and of deficits in hygiene.

Proliferation, Potential TMD Roles, Demarcation and ABM Treaty Compatibility.

DTIC Science & Technology

1994-09-01

Dr. Sergei Blagovolin Dr. Stephen Cambone Amb. Sidney Graybeal Dr. Patricia McFate Dr. Alexander Savelyev Mr. Willis Stanley Ms. Linda Vlahos...control, missile defense, and other international security issues. He served as the director of this study. Dr. Alexander Savelyev is Vice President of...Interview with Dr. Sergei Blagovolin and Alexander Savelyev , July 15,1994, 69. Interview with Amb. Kathleen Bailey, former Assistant Director of

78 FR 19502 - Information Collection Requests to Office of Management and Budget.

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-01

... Information Collection Requests (ICRs) to the Office of Management and Budget (OMB), Office of Information and... FURTHER INFORMATION CONTACT: Mr. Anthony Smith, Office of Information Management, telephone 202-475-3532... DEPARTMENT OF HOMELAND SECURITY Coast Guard [USCG-2013-0164] Information Collection Requests to...

78 FR 19505 - National Boating Safety Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-01

... DEPARTMENT OF HOMELAND SECURITY Coast Guard [USCG-2010-0164] National Boating Safety Advisory... Planning Subcommittee of the National Boating Safety Advisory Council (NBSAC) will meet via teleconference... boating safety program. This teleconference meeting will be open to the public. DATES: The teleconference...

78 FR 19507 - National Boating Safety Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-01

... DEPARTMENT OF HOMELAND SECURITY Coast Guard [USCG-2010-0164] National Boating Safety Advisory... Associated Equipment Subcommittee of the National Boating Safety Advisory Council (NBSAC) will meet via teleconference and online webinar to discuss safety issues related to boats and associated equipment. This...

78 FR 19506 - National Boating Safety Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-01

... DEPARTMENT OF HOMELAND SECURITY Coast Guard [USCG-2010-0164] National Boating Safety Advisory... Through People Subcommittee of the National Boating Safety Advisory Council (NBSAC) will meet via teleconference and online webinar to discuss issues related to improving safety of recreational boating through...

75 FR 53346 - Submission for OMB Emergency Review: Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-31

... DEPARTMENT OF LABOR Bureau of Labor Statistics Submission for OMB Emergency Review: Comment... submissions of responses. Agency: Bureau of Labor Statistics. Type of Review: Revision of currently approved collection. Title of Collection: National Compensation Survey. OMB Control Number: 1220-0164. Affected Public...

KSC-2014-2352

NASA Image and Video Library

2014-05-02

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, Don Dankert, a biological scientist in the NASA Environmental Management Branch of Center Operations, left, and Becky Bolt, a wildlife ecologist with InoMedic Health Applications Inc, plant the final shrub that is among 180,000 planted on a new 1.2-mile stretch of shoreline near Launch Pads 39A and B. Constant pounding from tropical storms, such as Hurricane Sandy in October of 2012, other weather systems and higher than usual tides, destroyed sand dunes protecting infrastructure at the spaceport. Photo credit: NASA/Dan Casper

Report on Component 2 - Designing New Methods for Visualizing Text in Spatial Contexts

DTIC Science & Technology

2012-10-31

W9132V-11-P-0010 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Alexander Savelyev , Scott Pezanowski, Anthony C. Robinson, and Alan M...e Component 2 – Designing New Methods for Visualizing Text in Spatial Contexts Alexander Savelyev , Scott Pezanowski, Anthony Robinson and Alan...Center, Penn State University Report on Component 2: Component 2 – Designing New Methods for Visualizing Text in Spatial Contexts Alexander

Historical Roots of Contemporary Debates on Soviet Military Doctrine and Defense

DTIC Science & Technology

1991-01-01

28 - institutchikis’ "new thinking" about war. According to one prolific Soviet researcher, Alexander Savelyev , war aims are now being redefined and...limits. Indeed, it may well 5 Discussions with Alexander Savelyev at the Institute of World Economy and International Relations (IMEMO), Moscow, January...examines the themes of and historical context for the writings of Soviet strategists of the 1920s, such as Alexander Svechin and Leon Trotsky, who

New Methods for Representing and Interacting with Qualitative Geographic Information

DTIC Science & Technology

2012-10-31

Penn State University Report on Component 3: SensePlace2 Evaluation Anthony C. Robinson, Scott Pezanowski, Alexander Savelyev , and Alan M...NUMBER 6. AUTHOR(S) Alexander Savelyev , Scott Pezanowski, Anthony C. Robinson, and Alan M. MacEachren 5d. PROJECT NUMBER 5e. TASK NUMBER 5f...2012. SensePlace2 Interface Mini-Guide Alan M. MacEachren, Alexander Savelyev , and Scott Pezanowski GeoVISTA Center, Pennsylvania State University

Evidence from lateral mobility studies for dynamic interactions of a mutant influenza hemagglutinin with coated pits.

PubMed

Fire, E; Zwart, D E; Roth, M G; Henis, Y I

1991-12-01

Replacement of cysteine at position 543 by tyrosine in the influenza virus hemagglutinin (HA) protein enables the endocytosis of the mutant protein (Tyr 543) through coated pits (Lazarovits, J., and M. G. Roth. 1988. Cell. 53:743-752). To investigate the interactions between Tyr 543 and the clathrin coats in the plasma membrane of live cells, we performed fluorescence photobleaching recovery measurements comparing the lateral mobilities of Tyr 543 (which enters coated pits) and wild-type HA (HA wt, which is excluded from coated pits), following their expression in CV-1 cells by SV-40 vectors. While both proteins exhibited the same high mobile fractions, the lateral diffusion rate of Tyr 543 was significantly slower than that of HA wt. Incubation of the cells in a sucrose-containing hypertonic medium, a treatment that disperses the membrane-associated coated pits, resulted in similar lateral mobilities for Tyr 543 and HA wt. These findings indicate that the lateral motion of Tyr 543 (but not of HA wt) is inhibited by transient interactions with coated pits (which are essentially immobile on the time scale of the lateral mobility measurements). Acidification of the cytoplasm by prepulsing the cells with NH4Cl (a treatment that arrests the pinching-off of coated vesicles from the plasma membrane and alters the clathrin lattice morphology) led to immobilization of a significant part of the Tyr 543 molecules, presumably due to their entrapment in coated pits for the entire duration of the lateral mobility measurement. Furthermore, in both untreated and cytosol-acidified cells, the restrictions on Tyr 543 mobility were less pronounced in the cold, suggesting that the mobility-restricting interactions are temperature dependent and become weaker at low temperatures. From these studies we conclude the following. (a) Lateral mobility measurements are capable of detecting interactions of transmembrane proteins with coated pits in intact cells. (b) The interactions of Tyr 543

Chickamauga National Military Park Tour Roads, Gordon's Slough Bridge, At ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Chickamauga National Military Park Tour Roads, Gordon's Slough Bridge, At the confluence of Alexander's Bridge Road and Gordon's Slough, southeast of Alexander's Bridge, Fort Oglethorpe, Catoosa County, GA

77 FR 68787 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-16

... of Information Management, Food and Drug Administration, 1350 Piccard Dr., PI50-400B, Rockville, MD... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2011-D-0164] Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment...

77 FR 61422 - National Boating Safety Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-09

... DEPARTMENT OF HOMELAND SECURITY Coast Guard [Docket No. USCG-2010-0164] National Boating Safety...: The National Boating Safety Advisory Council (NBSAC) and three of its subcommittees will meet on November 9-11, 2012, in Watsonville, CA, to discuss issues relating to recreational boating safety. The...

Underground Explosions

DTIC Science & Technology

2015-09-09

AVC‐VTN‐15‐G06 “Underground  Explosions”  By  Vitaly  V. Adushkin and Alexander...Language Book "UNDERGROUND EXPLOSIONS" Drs. Vitaly V. Adushkin and Alexander A. Spivak Dr. Anastasia Stroujkova and Professor Paul Richards Weston...SAQMMA13M2475 DOS/AVC/MNA UNLIMITED “Underground Explosions”, a Russian language book authored by Drs. Vitaly V. Adushkin and Alexander A. Spivak has been

Assessing Russian Reactions to U.S. Missile Defense

DTIC Science & Technology

2001-09-01

International Studies, 2001)18, 27. 108 See ibid., 14; and Alexander Savelyev , “Russian Strategic Forces: Their Future and the Issue of BMD,” A...International Peace; Monterey, CA: Monterey Institute of International Studies, 2001) 24, 26, 28. 110 Alexander Savelyev , “Russian Strategic Forces: Their...example, Alexander Savelyev of the Russian Academy of Sciences has made the point that “by all the standards of ‘strategic stability’ the deployment of

Quantum Communication Using Macroscopic Phase Entangled States

DTIC Science & Technology

2015-12-10

distribution with entanglement witnessing”, Physical Review A, v. 89, 012315 (2014). • David Simon , Gregg Jaeger, and Alexander Sergienko ’’Quantum...8217’Entanglement sudden death: a threat to advanced quantum key distribution?’’, Natural Computing, .v. 13, pp. 459-467 (2014). • David Simon and Alexander...What in the (quantum) world is macroscopic?”, Am. J. Phys. 82, 896 (2014) • Gregg Jaeger, David Simon , and Alexander V. Sergienko”, Implications

Strategic Culture and Ballistic Missile Defense: Russia and the United States

DTIC Science & Technology

1993-06-01

exist in some circles in Russia, as indicated by statements of Alexander Savelyev of the Institute for National Security and Strategic Studies in...Intelligence Report on Proliferation," See JPRS-TND-93-007, 5 March 1993. (57) Savelyev , Alexander . "A View from Russia. The ABM Treaty: Should We Keep It...34Russian Intelligence Report on Proliferation," See JPRS-TND-93-007, 5 March 1993. Savelyev , Alexander . "A View from Russia. The ABM Treaty: Should We Keep

Balancing Congressional Needs for Classified Information: A Case Study of the Strategic Defense initiative

DTIC Science & Technology

1993-05-17

Star Wars." Arms Control Today, May 1992, 29-30. Saucier, Aldric. "Lost in Space." New York Times, 9 March 1992, A17. Savelyev , Alexander . "Toward U.S...legislature will be unable to retain the secrecy of such material. In recent years, the 22 Alexander Hamilton, James Madison and John Jay, The Federalist...The Struggle for Democracy in America. Cambridge, Massachusetts: The Riverside Press, 1925. Boyd, Julian P. Number 7: Alexander Hamilton’s Secret

77 FR 23495 - Notice of Public Meeting, Eastern Washington Resource Advisory Council Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-19

...; HAG 12-0164] Notice of Public Meeting, Eastern Washington Resource Advisory Council Meeting AGENCY... 1972, the U.S. Department of the Interior, Bureau of Land Management (BLM) Eastern Washington Resource... of Land Management's Eastern Washington and San Juan Resource Management Plan, and the U.S. Forest...

78 FR 51753 - AUC, LLC Reno Creek, In Situ Project, New Source Material License Application

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

... NUCLEAR REGULATORY COMMISSION [Docket No. 040-09092; [NRC-2013-0164] AUC, LLC Reno Creek, In Situ Project, New Source Material License Application AGENCY: Nuclear Regulatory Commission. ACTION: Notice of..., AUC, LLC (AUC) submitted to the U.S. Nuclear Regulatory Commission (NRC) an application for a new...

77 FR 17084 - National Boating Safety Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-23

... DEPARTMENT OF HOMELAND SECURITY Coast Guard [Docket No. USCG-2010-0164] National Boating Safety...: The National Boating Safety Advisory Council (NBSAC) will meet on April 13-14, 2012, in Arlington, Virginia, to discuss issues relating to recreational boating safety. The meetings will be open to the...

76 FR 20686 - Draft Guidance for Industry on Safety Labeling Changes; Implementation of the Federal Food, Drug...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2011-D-0164] Draft Guidance for Industry on Safety Labeling Changes; Implementation of the Federal Food, Drug, and Cosmetic Act; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and...

At the Cosmonaut Hotel in Baikonur, Kazakhstan, Expedition 48-49 crewmember Kate Rubins of NASA takes a spin in a rotating chair to test her vestibular system June 30 as part of pre-launch activities. Rubins, Anatoly Ivanishin of Roscosmos and Takuya Onishi of the Japan Aerospace Exploration Agency will launch July 7, Baikonur time, on the Soyuz MS-01 spacecraft for a planned four-month mission on the International Space Station...NASA/Alexander Vysotsky.

NASA Image and Video Library

2016-06-30

At the Cosmonaut Hotel in Baikonur, Kazakhstan, Expedition 48-49 crewmember Kate Rubins of NASA takes a spin in a rotating chair to test her vestibular system June 30 as part of pre-launch activities. Rubins, Anatoly Ivanishin of Roscosmos and Takuya Onishi of the Japan Aerospace Exploration Agency will launch July 7, Baikonur time, on the Soyuz MS-01 spacecraft for a planned four-month mission on the International Space Station. NASA/Alexander Vysotsky

At the Cosmonaut Hotel in Baikonur, Kazakhstan, Expedition 48-49 crewmembers Anatoly Ivanishin of Roscosmos (foreground) and Takuya Onishi of the Japan Aerospace Exploration Agency conduct tests of their vestibular system on tilt tables June 30 as part of pre-launch activities. They and Kate Rubins of NASA will launch July 7, Baikonur time, on the Soyuz MS-01 spacecraft for a planned four-month mission on the International Space Station...NASA/Alexander Vysotsky.

NASA Image and Video Library

2016-06-30

At the Cosmonaut Hotel in Baikonur, Kazakhstan, Expedition 48-49 crewmembers Anatoly Ivanishin of Roscosmos (foreground) and Takuya Onishi of the Japan Aerospace Exploration Agency conduct tests of their vestibular system on tilt tables June 30 as part of pre-launch activities. They and Kate Rubins of NASA will launch July 7, Baikonur time, on the Soyuz MS-01 spacecraft for a planned four-month mission on the International Space Station. NASA/Alexander Vysotsky

At the Cosmonaut Hotel in Baikonur, Kazakhstan, Expedition 48-49 crewmember Takuya Onishi of the Japan Aerospace Exploration Agency takes a spin in a rotating chair to test his vestibular system June 30 as part of pre-launch activities. Onishi, Kate Rubins of NASA and Anatoly Ivanishin of Roscosmos will launch July 7, Baikonur time, on the Soyuz MS-01 spacecraft for a planned four-month mission on the International Space Station...NASA/Alexander Vysotsky.

NASA Image and Video Library

2016-06-30

At the Cosmonaut Hotel in Baikonur, Kazakhstan, Expedition 48-49 crewmember Takuya Onishi of the Japan Aerospace Exploration Agency takes a spin in a rotating chair to test his vestibular system June 30 as part of pre-launch activities. Onishi, Kate Rubins of NASA and Anatoly Ivanishin of Roscosmos will launch July 7, Baikonur time, on the Soyuz MS-01 spacecraft for a planned four-month mission on the International Space Station. NASA/Alexander Vysotsky

76 FR 5594 - National Institute of Environmental Health Sciences; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-01

.... Inst. of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive... Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709. Contact Person: Gwen W. Collman, PhD...

Community Education: The Making of an Empowering Profession.

ERIC Educational Resources Information Center

McConnell, Charlie, Ed.

The following papers are included: "Foreword" (Alexander); "Preface" (McConnell); "Editorial Introduction" (McConnell); "People Power" (Gibson); "Community Education within the Context of Reorganisation of Local Government" (Hughes); "The Challenge of Change" (Alexander Report);…

Lemay and Olds: Great Captains of Airpower

DTIC Science & Technology

2016-12-01

by saying, “I will listen to you and learn from you , but soon I’m gonna be better than all of you , and when I know more about your job than you do...punishment.”19 Alexander paid his Macedonian troops well and ensured their widows and families would be cared for.20 In 324 BCE, Alexander blessed ...Darius.27 Alexander’s bet paid off. The Persian attack on his right wing opened up a gap in the Persian lines through which Alexander charged

28 CFR 0.165 - Recommendations to the Deputy Attorney General or Associate Attorney General, as appropriate...

Code of Federal Regulations, 2010 CFR

2010-07-01

... General or Associate Attorney General, as appropriate, that certain claims be closed. 0.165 Section 0.165... Recommendations to the Deputy Attorney General or Associate Attorney General, as appropriate, that certain claims... the authority delegated by §§ 0.160(a) and 0.164, the Assistant Attorney General concerned shall, when...

7 CFR 1924.150 - OMB Control Number.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 12 2011-01-01 2011-01-01 false OMB Control Number. 1924.150 Section 1924.150... Number. The reporting requirements contained in this subpart have been approved by the Office of Management and Budget (OMB) and have been assigned OMB control number 0575-0164. Public reporting burden for...

7 CFR 1924.150 - OMB Control Number.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 12 2014-01-01 2013-01-01 true OMB Control Number. 1924.150 Section 1924.150... Number. The reporting requirements contained in this subpart have been approved by the Office of Management and Budget (OMB) and have been assigned OMB control number 0575-0164. Public reporting burden for...

7 CFR 1924.150 - OMB Control Number.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 12 2012-01-01 2012-01-01 false OMB Control Number. 1924.150 Section 1924.150... Number. The reporting requirements contained in this subpart have been approved by the Office of Management and Budget (OMB) and have been assigned OMB control number 0575-0164. Public reporting burden for...

10 CFR 54.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... requiring aging management review in accordance with § 54.21(a) for license renewal have been identified and that the effects of aging on the functionality of such structures and components will be managed to.... Time-limited aging analyses, for the purposes of this part, are those licensee calculations and...

10 CFR 54.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... requiring aging management review in accordance with § 54.21(a) for license renewal have been identified and that the effects of aging on the functionality of such structures and components will be managed to.... Time-limited aging analyses, for the purposes of this part, are those licensee calculations and...

10 CFR 54.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... requiring aging management review in accordance with § 54.21(a) for license renewal have been identified and that the effects of aging on the functionality of such structures and components will be managed to.... Time-limited aging analyses, for the purposes of this part, are those licensee calculations and...

31 CFR 543.701 - Penalties.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Penalties. (a) Attention is directed to section 206 of the International Emergency Economic Powers Act (50 U... fine, imprisonment, or both and any property, funds, securities, papers, or other articles or documents...

10 CFR 54.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

.... The CLB includes the NRC regulations contained in 10 CFR parts 2, 19, 20, 21, 26, 30, 40, 50, 51, 52.... Nuclear power plant means a nuclear power facility of a type described in 10 CFR 50.21(b) or 50.22. Renewed combined license means a combined license originally issued under part 52 of this chapter for...

31 CFR 543.701 - Penalties.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Penalties. (a) Attention is directed to section 206 of the International Emergency Economic Powers Act (50 U... adjustment pursuant to the Federal Civil Penalties Inflation Adjustment Act of 1990 (Pub. L. 101-410, as... pursuant to 18 U.S.C. 3571. (c) Attention is directed to section 5 of the United Nations Participation Act...

32 CFR 54.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... having in effect a plan approved under part D of title IV of the Social Security Act (42 U.S.C. 651-664... the court that has authority to issue an order against a member for the support and maintenance of a... not limited to, payments to provide for health care, education, recreation, and clothing or to meet...

32 CFR 54.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... having in effect a plan approved under part D of title IV of the Social Security Act (42 U.S.C. 651-664... the court that has authority to issue an order against a member for the support and maintenance of a... not limited to, payments to provide for health care, education, recreation, and clothing or to meet...

32 CFR 54.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... having in effect a plan approved under part D of title IV of the Social Security Act (42 U.S.C. 651-664... the court that has authority to issue an order against a member for the support and maintenance of a... not limited to, payments to provide for health care, education, recreation, and clothing or to meet...

32 CFR 54.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... having in effect a plan approved under part D of title IV of the Social Security Act (42 U.S.C. 651-664... the court that has authority to issue an order against a member for the support and maintenance of a... not limited to, payments to provide for health care, education, recreation, and clothing or to meet...

32 CFR 54.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... having in effect a plan approved under part D of title IV of the Social Security Act (42 U.S.C. 651-664... the court that has authority to issue an order against a member for the support and maintenance of a... not limited to, payments to provide for health care, education, recreation, and clothing or to meet...

Confirmation of the identity of the type host of the louse Halipeurus fallacis (Phthiraptera: Philopteridae).

PubMed

Palma, Ricardo L

2018-04-09

Alexander (1954: 489) recorded a petrel (Aves: Procellariiformes) captured alive on board a ship in the Indian Ocean by Mr W.W.A. Phillips who, after removing some lice, liberated it the following morning. Alexander (1954) identified that petrel as the species "Pterodroma aterrima Bonaparte", now placed in the genus Pseudobulweria. The lice were kept in the collection of the then British Museum (Natural History), now the Natural History Museum, London, England. Jouanin (1955) published a new species of petrel from the Indian Ocean as Bulweria fallax. Jouanin (1957: 19) discussed the identity of the petrel identified by Alexander (1954) as Pterodroma aterrima, stating that the descriptive data given by Alexander (1954) did not clearly fit either P. aterrima or B. fallax. However, considering the geographical coordinates where the bird was captured, Jouanin (1957) believed it was more likely Bulweria fallax.

MATRYOSHKA-R. Receiving and preparing of PADLE detectors for return

NASA Image and Video Library

2014-09-09

ISS040-E-130021 (9 Sept. 2014) --- European Space Agency astronaut Alexander Gerst (left), writes a note while Russian cosmonaut Alexander Skvortsov, both Expedition 40 flight engineers, looks on in the Zvezda Service Module of the International Space Station.

Leadership as an Emergent Phenomenon: A Framework for Complexity and Adaptability

DTIC Science & Technology

2008-06-01

psychologists, including Kegan (Kegan, 1994; Torbert, 1991), Alexander (Alexander and Langer, 1990), Kohlberg (1984...development stages from symbiosis to conscious universal embeddedness. In M. L. Commons, C. Armon, L. Kohlberg , F. A. Richards, T. A. Grotzer, and J. D

MATRYOSHKA-R. Receiving and preparing of PADLE detectors for return

NASA Image and Video Library

2014-09-09

ISS040-E-130025 (9 Sept. 2014) --- European Space Agency astronaut Alexander Gerst (right) and Russian cosmonaut Alexander Skvortsov, both Expedition 40 flight engineers, work with a package of dosimeters in the Zvezda Service Module of the International Space Station.

78 FR 18920 - Airworthiness Directives; Austro Engine GmbH Engines

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-28

...-0164; Directorate Identifier 2013-NE-10-AD] RIN 2120-AA64 Airworthiness Directives; Austro Engine GmbH...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all Austro Engine GmbH model E4.... Fax: 202-493-2251. For service information identified in this proposed AD, contact Austro Engine GmbH...

At the Cosmonaut Hotel in Baikonur, Kazakhstan, Expedition 48-49 prime crewmember Kate Rubins of NASA (left) and her backup, NASA���s Peggy Whitson (right) share a game of chess June 30 during pre-launch activities. Rubins, Anatoly Ivanishin of Roscosmos and Takuya Onishi of the Japan Aerospace Exploration Agency, will launch July 7, Baikonur time, on the Soyuz MS-01 spacecraft for a planned four-month mission on the International Space Station...NASA/Alexander Vysotsky.

NASA Image and Video Library

2016-06-30

At the Cosmonaut Hotel in Baikonur, Kazakhstan, Expedition 48-49 prime crewmember Kate Rubins of NASA (left) and her backup, NASA’s Peggy Whitson (right) share a game of chess June 30 during pre-launch activities. Rubins, Anatoly Ivanishin of Roscosmos and Takuya Onishi of the Japan Aerospace Exploration Agency, will launch July 7, Baikonur time, on the Soyuz MS-01 spacecraft for a planned four-month mission on the International Space Station. NASA/Alexander Vysotsky

77 FR 48164 - National Institute Environmental Health Sciences; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-13

... Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC.... of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive... applications. Place: Nat. Inst. of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W...

Estrogen Receptor α L543A,L544A Mutation Changes Antagonists to Agonists, Correlating with the Ligand Binding Domain Dimerization Associated with DNA Binding Activity*

PubMed Central

Arao, Yukitomo; Hamilton, Katherine J.; Coons, Laurel A.; Korach, Kenneth S.

2013-01-01

A ligand-dependent nuclear transcription factor, ERα has two transactivating functional domains (AF), AF-1 and AF-2. AF-1 is localized in the N-terminal region, and AF-2 is distributed in the C-terminal ligand-binding domain (LBD) of the ERα protein. Helix 12 (H12) in the LBD is a component of the AF-2, and the configuration of H12 is ligand-inducible to an active or inactive form. We demonstrated previously that the ERα mutant (AF2ER) possessing L543A,L544A mutations in H12 disrupts AF-2 function and reverses antagonists such as fulvestrant/ICI182780 (ICI) or 4-hydoxytamoxifen (OHT) into agonists in the AF2ER knock-in mouse. Our previous in vitro studies suggested that the mode of AF2ER activation is similar to the partial agonist activity of OHT for WT-ERα. However, it is still unclear how antagonists activate ERα. To understand the molecular mechanism of antagonist reversal activity, we analyzed the correlation between the ICI-dependent estrogen-responsive element-mediated transcription activity of AF2ER and AF2ER-LBD dimerization activity. We report here that ICI-dependent AF2ER activation correlated with the activity of AF2ER-LBD homodimerization. Prevention of dimerization impaired the ICI-dependent ERE binding and transcription activity of AF2ER. The dislocation of H12 caused ICI-dependent LBD homodimerization involving the F-domain, the adjoining region of H12. Furthermore, F-domain truncation also strongly depressed the dimerization of WT-ERα-LBD with antagonists but not with E2. AF2ER activation levels with ICI, OHT, and raloxifene were parallel with the degree of AF2ER-LBD homodimerization, supporting a mechanism that antagonist-dependent LBD homodimerization involving the F-domain results in antagonist reversal activity of H12-mutated ERα. PMID:23733188

76 FR 57065 - National Institute of Environmental Health Sciences; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-15

... Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709... personnel issues. Place: Nat. Inst. of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111..., Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709. Closed...

77 FR 3480 - National Institute of Environmental Health Sciences Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-24

..., Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709. Closed: February 15, 2012... Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle... and issues. Place: Nat. Inst. of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111...

77 FR 18252 - National Institute of Environmental Health Sciences; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-27

... Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T.W. Alexander Drive, Research Triangle... issues. Place: Nat. Inst. of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W..., Rodbell Auditorium, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709. Contact Person: Gwen W...

75 FR 19981 - National Institute of Environmental Health Sciences; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-16

... Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle... issues. Place: Nat. Inst. of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W..., Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709. Contact Person: Gwen W...

77 FR 9673 - National Institute of Environmental Health Sciences; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-17

... Neurobiology. Place: Nat. Inst. of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W... Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709...: Nat. Inst. of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander...

Attitudes of Major Soviet Nationalities. Volume 3. The Transcaucasus. Armenia, Georgia, Azerbaidzhan

DTIC Science & Technology

1973-06-01

Tabidze, a "People’s Poet of Georgia," Georgi Leonidze, Irakly Abashidze, Alexander Gomisshvlli, Crigol Abashidze, Alexander Abasheli, Sandro Shanshiashvili...era. Work of this kind is still being carried on by such artists as Irakly chiauri, Dmitry Kipshidze, Koba Guruli, and Gura Gabashvili. Professional

77 FR 74198 - National Institute Environmental Health Sciences Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-13

... Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC... issues. Place: Nat. Inst. of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W... Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709. Contact Person: Gwen W. Collman, Ph...

1. COPY OF A LATE 19TH CENTURY BUSINESS CARD FOR ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. COPY OF A LATE 19TH CENTURY BUSINESS CARD FOR A. ALEXANDER & SON FLOURING MILLS. CARD OWNED BY THOMAS R. WILSON. Photographer: Berni Rich, Score Photographers, September 1986. - Alexander's Grist Mill, Lock 37 on Ohio & Erie Canal, South of Cleveland, Valley View, Cuyahoga County, OH

Organizations in Transition. Symposium 41. [Concurrent Symposium Session at AHRD Annual Conference, 2000.

ERIC Educational Resources Information Center

2000

This document contains three papers from a symposium on organizations in transition that was conducted as part of a conference on human resource development (HRD). "Human Resource Development in an Industry in Transition: The Case of the Russian Banking Sector" (Alexander Ardichvili, Alexander Gasparishvili) reports on a study…

78 FR 18997 - National Institute of Environmental Health Sciences; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-28

... Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC... personnel issues. Place: Nat. Inst. of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111... Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709. Closed: April 15, 2013, 3:15 p.m. to...

ATV docking ops

NASA Image and Video Library

2014-08-12

ISS040-E-091634 (12 Aug. 2014) --- In the Zvezda Service Module, European Space Agency astronaut Alexander Gerst (left) and Russian cosmonaut Alexander Skvortsov, both Expedition 40 flight engineers, monitor the approach and docking of ESA's "Georges Lemaitre" Automated Transfer Vehicle-5 (ATV-5) to the International Space Station.

ATV docking ops

NASA Image and Video Library

2014-08-12

ISS040-E-091638 (12 Aug. 2014) --- In the Zvezda Service Module, European Space Agency astronaut Alexander Gerst (left) and Russian cosmonaut Alexander Skvortsov, both Expedition 40 flight engineers, monitor the approach and docking of ESA's "Georges Lemaitre" Automated Transfer Vehicle-5 (ATV-5) to the International Space Station.