Sample records for alpha particle energy

  1. Alpha Particle

    Microsoft Academic Search

    P. Murdin

    2000-01-01

    Term that is sometimes used to describe a helium nucleus, a positively charged particle that consists of two protons and two neutrons, bound together. Alpha particles, which were discovered by Ernest Rutherford (1871-1937) in 1898, are emitted by atomic nuclei that are undergoing alpha radioactivity. During this process, an unstable heavy nucleus spontaneously emits an alpha particle and transmut...

  2. Measurement of alpha particle energy using windowless electret ion chambers.

    PubMed

    Dua, S K; Kotrappa, P; Srivastava, R; Ebadian, M A; Stieff, L R

    2002-10-01

    Electret ion chambers are inexpensive, lightweight, robust, commercially available, passive, charge-integrating devices for accurate measurement of different ionizing radiations. In an earlier work a chamber of dimensions larger than the range of alpha particles having aluminized Mylar windows of different thickness was used for measurement of alpha radiation. Correlation between electret mid-point voltage, alpha particle energy, and response was developed and it was shown that this chamber could be used for estimating the effective energy of an unknown alpha source. In the present study, the electret ion chamber is used in the windowless mode so that the alpha particles dissipate their entire energy inside the volume, and the alpha particle energy is determined from the first principles. This requires that alpha disintegration rate be accurately known or measured by an alternate method. The measured energies were within 1 to 4% of the true values for different sources (230Th, 237Np, 239Pu, 241Am, and 224Cm). This method finds application in quantitative determination of alpha energy absorbed in thin membrane and, hence, the absorbed dose. PMID:12240732

  3. Enhanced production of low energy electrons by alpha particle impact.

    PubMed

    Kim, Hong-Keun; Titze, Jasmin; Schöffler, Markus; Trinter, Florian; Waitz, Markus; Voigtsberger, Jörg; Sann, Hendrik; Meckel, Moritz; Stuck, Christian; Lenz, Ute; Odenweller, Matthias; Neumann, Nadine; Schössler, Sven; Ullmann-Pfleger, Klaus; Ulrich, Birte; Fraga, Rui Costa; Petridis, Nikos; Metz, Daniel; Jung, Annika; Grisenti, Robert; Czasch, Achim; Jagutzki, Ottmar; Schmidt, Lothar; Jahnke, Till; Schmidt-Böcking, Horst; Dörner, Reinhard

    2011-07-19

    Radiation damage to living tissue stems not only from primary ionizing particles but to a substantial fraction from the dissociative attachment of secondary electrons with energies below the ionization threshold. We show that the emission yield of those low energy electrons increases dramatically in ion-atom collisions depending on whether or not the target atoms are isolated or embedded in an environment. Only when the atom that has been ionized and excited by the primary particle impact is in immediate proximity of another atom is a fragmentation route known as interatomic Coulombic decay (ICD) enabled. This leads to the emission of a low energy electron. Over the past decade ICD was explored in several experiments following photoionization. Most recent results show its observation even in water clusters. Here we show the quantitative role of ICD for the production of low energy electrons by ion impact, thus approaching a scenario closer to that of radiation damage by alpha particles: We choose ion energies on the maximum of the Bragg peak where energy is most efficiently deposited in tissue. We compare the electron production after colliding He(+) ions on isolated Ne atoms and on Ne dimers (Ne(2)). In the latter case the Ne atom impacted is surrounded by a most simple environment already opening ICD as a deexcitation channel. As a consequence, we find a dramatically enhanced low energy electron yield. The results suggest that ICD may have a significant influence on cell survival after exposure to ionizing radiation. PMID:21730184

  4. Summary of Alpha Particle Transport

    SciTech Connect

    Medley, S.S.; White, R.B.; Zweben, S.J.

    1998-08-19

    This paper summarizes the talks on alpha particle transport which were presented at the 5th International Atomic Energy Agency's Technical Committee Meeting on "Alpha Particles in Fusion Research" held at the Joint European Torus, England in September 1997.

  5. Utility of extracting {alpha}-particle energy by waves

    SciTech Connect

    Fisch, N.J.; Herrmann, M.C.

    1994-05-01

    The utility of extracting {alpha}-particle power, and then diverting this power to fast fuel ions, is investigated. As power is diverted to fast ions and then to ions, a number of effects come into play, as the relative amounts of pressure taken up by electrons, fuel ions, and fast {alpha}-particles shift. In addition, if the {alpha}-particle power is diverted to fast fuel ions, there is an enhanced fusion reactivity because of the nonthermal component of the ion distribution. Some useful expressions for describing these effects are derived, and it is shown that fusion reactors with power density about twice what otherwise might be obtained can be contemplated, so long as a substantial amount of the {alpha}-particle power can be diverted. Interestingly, in this mode of operation, once the electron heat is sufficiently confined, further improvement in confinement is actually not desirable. A similar improvement in fusion power density can be obtained for advanced fuel mixtures such as D-He{sup 3}, where the power of both the energetic {alpha}-particles and the energetic protons might be diverted advantageously.

  6. Energy dependence of the differential W-value of alpha particles in tissue-equivalent gas

    Microsoft Academic Search

    J. Booz; Th Smit; A. Waker

    1972-01-01

    The linear ion density of alpha -particles of energies 0.27 to 5.3 MeV was measured in tissue-equivalent gas. The results were compared with experimental and theoretical mass stopping powers in order to evaluate the differential W-value of alpha -particles, walpha . Above 1.6 MeV walpha was within 3% agreement with Winfinity , the constant W-value of electrons. For low energies

  7. Nuclear reactions induced by high-energy alpha particles

    NASA Technical Reports Server (NTRS)

    Shen, B. S. P.

    1974-01-01

    Experimental and theoretical studies of nuclear reactions induced by high energy protons and heavier ions are included. Fundamental data needed in the shielding, dosimetry, and radiobiology of high energy particles produced by accelerators were generated, along with data on cosmic ray interaction with matter. The mechanism of high energy nucleon-nucleus reactions is also examined, especially for light target nuclei of mass number comparable to that of biological tissue.

  8. Imaging alpha particle detector

    DOEpatents

    Anderson, D.F.

    1980-10-29

    A method and apparatus for detecting and imaging alpha particles sources is described. A dielectric coated high voltage electrode and a tungsten wire grid constitute a diode configuration discharge generator for electrons dislodged from atoms or molecules located in between these electrodes when struck by alpha particles from a source to be quantitatively or qualitatively analyzed. A thin polyester film window allows the alpha particles to pass into the gas enclosure and the combination of the glass electrode, grid and window is light transparent such that the details of the source which is imaged with high resolution and sensitivity by the sparks produced can be observed visually as well. The source can be viewed directly, electronically counted or integrated over time using photographic methods. A significant increase in sensitivity over other alpha particle detectors is observed, and the device has very low sensitivity to gamma or beta emissions which might otherwise appear as noise on the alpha particle signal.

  9. Anomalous energy loss distributions of alpha particles in heavily implanted thin aluminium films

    Microsoft Academic Search

    K. M. Barfoot; S. E. Donnelly; R. Werz; P. Rietveld

    1982-01-01

    Anomalous energy loss distributions of Gd alpha particles have been observed in heavily implanted thin aluminium films. It is surmised that thin film micro-wrinkling is responsible for the observed effect and that the novel technique of energy loss spectral analysis (ELSA) should be useful in studies of the topography of such films.

  10. cap alpha. Particle confinement in compact tori

    Microsoft Academic Search

    Bozhokin

    1986-01-01

    The motion of high-energy ..cap alpha.. particles in compact tori is studied. The classically accessible regions of motion of charged particles are found. The conditions are formulated under which the ..cap alpha.. particles produced in fusion reactions are absolutely confined. An ..cap alpha.. particle starting in a region enclosed by a ''critical'' surface will never, in the course of its

  11. RADON AND PROGENY ALPHA-PARTICLE ENERGY ANALYSIS USING NUCLEAR TRACK METHODOLOGY

    SciTech Connect

    Espinosa Garcia, Guillermo [ORNL; Golzarri y Moreno, Dr. Jose Ignacio [Instituto de Fisica, Mexico; Bogard, James S [ORNL

    2008-01-01

    A preliminary procedure for alpha energy analysis of radon and progeny using Nuclear Track Methodology (NTM) is described in this paper. The method is based on the relationship between alpha-particle energies deposited in polycarbonate material (CR-39) and the track size developed after a well-established chemical etching process. Track geometry, defined by parameters such as major or minor diameters, track area and overall track length, is shown to correlate with alpha-particle energy over the range 6.00 MeV (218Po) to 7.69 MeV (214Po). Track features are measured and the data analyzed automatically using a digital imaging system and commercial PC software. Examination of particle track diameters in CR-39 exposed to environmental radon reveals a multi-modal distribution. Locations of the maxima in this distribution are highly correlated with alpha particle energies of radon daughters, and the distributions are sufficiently resolved to identify the radioisotopes. This method can be useful for estimating the radiation dose from indoor exposure to radon and its progeny.

  12. Acceleration of low-energy protons and alpha particles at interplanetary shock waves

    NASA Technical Reports Server (NTRS)

    Scholer, M.; Hovestadt, D.; Ipavich, F. M.; Gloeckler, G.

    1983-01-01

    The low-energy protons and alpha particles in the energy range 30 keV/charge to 150 keV/charge associated with three different interplanetary shock waves in the immediate preshock and postshock region are studied using data obtained by the ISEE 3. The spatial distributions in the preshock and postshock medium are presented, and the dependence of the phase space density at different energies on the distance from the shock and on the form of the distribution function of both species immediately at the shock is examined. It is found that in the preshock region the particles are flowing in the solar wind frame of reference away from the shock and in the postshock medium the distribution is more or less isotropic in this frame of reference. The distribution function in the postshock region can be represented by a power law in energy which has the same spectral exponent for both protons and alpha particles. It is concluded that the first-order Fermi acceleration process can consistently explain the data, although the spectra of diffuse bow shock associated particles are different from the spectra of the interplanetary shock-associated particles in the immediate vicinity of the shock. In addition, the mean free path of the low energy ions in the preshock medium is found to be considerably smaller than the mean free path determined by the turbulence of the background interplanetary medium.

  13. cap alpha. -Particle confinement in compact tori

    SciTech Connect

    Bozhokin, S.V.

    1986-11-01

    The motion of high-energy ..cap alpha.. particles in compact tori is studied. The classically accessible regions of motion of charged particles are found. The conditions are formulated under which the ..cap alpha.. particles produced in fusion reactions are absolutely confined. An ..cap alpha.. particle starting in a region enclosed by a ''critical'' surface will never, in the course of its motion, intersect the separatrix of a compact torus. These critical surfaces are constructed. The ratio of the volume of absolute ..cap alpha.. confinement to the total volume of a compact torus is calculated as a function of the magnetic field strength and the dimensions of the compact torus.

  14. Comparitive Ionization Energies for Protons, Deuterons and Alpha Particles in High Purity Germanium and Si(Li) Nuclear Radiation Detectors

    Microsoft Academic Search

    M. Martini; T. W. Raudorf; W. R. Stott; J. C. Waddington

    1975-01-01

    Relative measurements of the average energy, ż, expended for electron-hole pair generation in silicon and high purity germanium detectors were made using 10 to 19 MeV proton, deuteron and alpha particle beams. The results show that ż is constant for different particles in high purity germanium detectors but not in silicon detectors. A model is presented which could explain both

  15. Behavior of low-energy protons and alpha particles during a disturbed time period

    NASA Technical Reports Server (NTRS)

    Ipavich, F. M.; Gloeckler, G.; Fan, C. Y.; Hovestadt, D.

    1976-01-01

    The paper presents observations of 130- to 1200-keV protons and 40- to 420-keV/nucleon alpha particles made on the earth-orbiting spacecraft Imp 8 and Imp 7 during an active solar period in September 1974, concentrating, in particular, on an energetic storm particle (ESP) event observed in association with an interplanetary shock wave on September 21. It is found that the observed variations in the proton-to-alpha particle ratios and spectral indices can be explained either by 'pileup' or by acceleration models of ESP events. Several instances of local acceleration of particles in the near-earth environment are also discussed.

  16. Calculations of Alpha-Particle Trajectories for Long-Range Alpha Particles Emitted in Spontaneous Fission

    Microsoft Academic Search

    Y. Boneh; Z. Fraenkel; I. Nebenzahl

    1967-01-01

    Calculated angular and energy distributions of the alpha particles in long-range alpha-particle fission are presented. The distributions were obtained from calculated alpha-particle trajectories based on a three-point-charge model for the scissioning nucleus. The calculation is two dimensional, and spontaneous fission (no preferred direction) is assumed. This reduces the number of free variables of the system to seven (except for the

  17. Alpha-particle spectrometer experiment

    NASA Technical Reports Server (NTRS)

    Gorenstein, P.; Bjorkholm, P.

    1972-01-01

    Mapping the radon emanation of the moon was studied to find potential areas of high activity by detection of radon isotopes and their daughter products. It was felt that based on observation of regions overflown by Apollo spacecraft and within the field of view of the alpha-particle spectrometer, a radon map could be constructed, identifying and locating lunar areas of outgassing. The basic theory of radon migration from natural concentrations of uranium and thorium is discussed in terms of radon decay and the production of alpha particles. The preliminary analysis of the results indicates no significant alpha emission.

  18. Lower hybrid instability driven by mono-energy {alpha}-particles with finite pitch angle spread in a plasma

    SciTech Connect

    Kumar, Pawan; Singh, Vishwesh; Tripathi, V. K. [Department of Physics, IIT Delhi, New Delhi-110016 (India)

    2013-02-15

    A kinetic formalism of lower hybrid wave instability, driven by mono-energy {alpha}-particles with finite pitch angle spread, is developed. The instability arises through cyclotron resonance interaction with high cyclotron harmonics of {alpha}-particles. The {alpha}-particles produced in D-T fusion reactions have huge Larmor radii ({approx}10 cm) as compared to the wavelength of the lower hybrid wave, whereas their speed is an order of magnitude smaller than the speed of light in vacuum. As a result, large parallel phase velocity lower hybrid waves, suitable for current drive in tokamak, are driven unstable via coupling to high cyclotron harmonics. The growth rate decreases with increase in pitch angle spread of the beam. At typical electron density of {approx}10{sup 19} m{sup -3}, magnetic field {approx}4 Tesla and {alpha}-particle concentration {approx}0.1%, the large parallel phase velocity lower hybrid wave grows on the time scale of 20 ion cyclotron periods. The growth rate decreases with plasma density.

  19. Malignant transformation of human benign prostate epithelial cells by high linear energy transfer alpha-particles.

    PubMed

    Li, Hongzhen; Gu, Yongpeng; Miki, Jun; Hukku, Bharati; McLeod, David G; Hei, Tom K; Rhim, Johng S

    2007-09-01

    Although epidemiological studies have suggested a positive correlation between environmental radon exposure and prostate cancer, the mechanism involved is not clear. In the present study, we examined the oncogenic transforming potency of alpha-particles using non-tumorigenic, telomerase-immortalized human benign prostate epithelial cells. We report the malignant transformation of human benign prostate epithelial cells after a single exposure to 0.6 Gy dose of alpha-particles. Transformed cells showed anchorage-independent growth in soft agar and induced progressively growing tumors when transplanted into SCID mice. The tumors were characterized histologically as poorly differentiated adenocarcinomas. The cell line derived from tumor (SCID 5015), like the unirradiated cells, expressed cytokeratin 5, 8 and 18, NKX3.1 and AMACR. The malignant cells showed increased secretion of MMP2. Stepwise chromosomal changes in the progression to tumorigenicity were observed. Chromosome abnormalities were identified in both irradiated and tumorigenic cells relative to the non-irradiated control cells. Prominent changes in chromosomes 6, 11 and 16, as well as mutations and deletions of the p53 gene were observed in the tumor outgrowth and tumor cells. These findings provide the first evidence of malignant transformation of human benign prostate epithelial cells exposed to a single dose of alpha-particles. This model provides an opportunity to study the cellular and molecular alterations that occur in radiation carcinogenesis in human prostate cells. PMID:17671680

  20. Recommended Energy and Intensity Values of Alpha Particles from Radioactive Decay

    Microsoft Academic Search

    A. Rytz

    1991-01-01

    The present compilation in the third revised version of a collection of selected Îą-particle data found in the literature. It includes 516 values from 286 Îą-particle emitters, corresponding to an increase of 12% and 17%, respectively, over the 1979 version. The weighted means form a consistent set of recommended energy and branching values.

  1. Nuclear diagnostic for fast alpha particles

    DOEpatents

    Grisham, Larry R. (Lawrence Township, Mercer County, NJ); Post, Jr., Douglass E. (Belle Mead, NJ); Dawson, John M. (Pacific Palisades, CA)

    1986-01-01

    Measurement of the velocity distribution of confined energetic alpha particles resulting from deuterium-tritium fusion reactions in a magnetically contained plasma is provided. The fusion plasma is seeded with energetic boron neutrals for producing, by means of the reaction .sup.10 B (.alpha.,n) .sup.13 N reaction, radioactive nitrogen nuclei which are then collected by a probe. The radioactivity of the probe is then measured by conventional techniques in determining the energy distribution of the alpha particles in the plasma. In a preferred embodiment, diborane gas (B.sub.2 H.sub.6) is the source of the boron neutrals to produce .sup.13 N which decays almost exclusively by positron emission with a convenient half-life of 10 minutes.

  2. Analytic expressions for {alpha} particle preformation in heavy nuclei

    SciTech Connect

    Zhang, H. F.; Wang, Y. J.; Dong, J. M. [School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China); Royer, G. [Laboratoire Subatech, UMR IN2P3/CNRS Universite Ecole des Mines, Nantes 44 (France); Zuo, W.; Li, J. Q. [School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China); Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China)

    2009-11-15

    Experimental {alpha} decay energies and half-lives are investigated systematically to extract {alpha} particle preformation in heavy nuclei. Formulas for the preformation factors are proposed that can be used to guide microscopic studies on preformation factors and perform accurate calculations of the {alpha} decay half-lives. There is little evidence for the existence of an island of long stability of superheavy nuclei.

  3. ITER alpha particle diagnostics using knock-on ion tails

    SciTech Connect

    Fisher, R.K.; Parks, P.B.; McChesney, J.M. [and others

    1995-09-01

    Alpha particles will play a critical role in the physics and successful operation of ITER. Achieving fusion ignition requires that the {alpha} particles created by deuterium-tritium (D-T) reactions deposit a large fraction of their energy in the reacting plasma before they are lost. Toroidal field ripple can localize any alpha particle losses and cause first wall damage. We have proposed a new method of measuring the fast confined {alpha}-particle distribution in a reacting plasma. The same elastic collisions that transfer the alpha energy to the D-T plasma ions and allow fusion ignition will also create a high energy tail on the deuterium and tritium ion energy distributions. Some of these energetic tail ions will undergo fusion reactions with the background plasma producing neutrons whose energy is increased significantly above 14 MeV due to the kinetic energy of the reacting ions. Measurement of this high energy tail on the D-T neutron distribution as a function of plasma minor radius would provide information on the alpha density profile with a time response equal to the ion slowing-down time. Although this technique may provide only limited information on the {alpha}-particle energy distribution, experimental studies of fast ions on existing tokamaks have shown that the observed slowing-down is essentially classical. Hence the {alpha}-energy distribution is expected to be classical except in situations where the {alpha}-confinement is poor. The confinement of {alpha}`s can be affected by ripple losses and a number of instabilities. Toroidal field ripple can cause both prompt orbit losses and stochastic ripple diffusion losses. Magnetohydrodynamic activity, including fishbone instabilities, toroidal Alfven eigenmodes, and sawtooth oscillations, may also affect alpha confinement. The diagnostic proposed here, by monitoring the confined alpha population, can provide valuable information on the confinement of fast alphas in a reacting plasma.

  4. Alpha particle analysis using PEARLS spectrometry

    SciTech Connect

    McKlveen, J.W.; Klingler, G.W.; McDowell, W.J.; Case, G.N.

    1984-01-01

    Alpha particle assay by conventional plate-counting methods is difficult because chemical separation, tracer techniques, and/or self-absorption losses in the final sample may cause either non-reproducible results or create unacceptable errors. PEARLS (Photon-Electron Rejecting Alpha Liquid Scintillation) Spectrometry is an attractive alternative since radionuclides may be extracted into a scintillator in which there would be no self-absorption or geometry problems and in which up to 100% chemical recovery and counting efficiency is possible. Sample preparation may include extraction of the alpha emitter of interest by a specific organic-phase-soluble compound directly into the liquid scintillator. Detection electronics use energy and pulse-shape discrimination to provide discrete alpha spectra and virtual absence of beta and gamma backgrounds. Backgrounds on the order of 0.01 cpm are readily achievable. Accuracy and reproducibility are typically in the 100 +-1% range. Specific procedures have been developed for gross alpha, uranium, plutonium, thorium, and polonium assay. This paper will review liquid scintillation alpha counting methods and reference some of the specific applications. 8 refs., 1 fig.

  5. {alpha}-particle spectrum in the reaction p + {sup 11}B {yields} {alpha} + {sup 8}Be* {yields} 3{alpha}

    SciTech Connect

    Dmitriev, V. F., E-mail: dmitriev@inp.nsk.s [Budker Institute of Nuclear Physics (Russian Federation)

    2009-07-15

    Using a simple phenomenological parametrization of the reaction amplitude we calculated {alpha}-particle spectrumin the reaction p + {sup 11}B {yields} {alpha} + {sup 8}Be* {yields} 3{alpha} at the resonance proton energy of 675 keV. The parametrization includes Breit-Wigner factor with an energy-dependent width for intermediate {sup 8}Be* state and the Coulomb and the centrifugal factors in {alpha}-particle-emission vertices. The shape of the spectrum consists of a well-defined peak corresponding to emission of the primary {alpha} and a flat shoulder going down to very low energy. We found that below 1.5MeV there are 17.5% of {alpha}'s and below 1MeV there are 11% of them.

  6. Measurement of the OXYGEN-17(PROTON, Alpha Particle) Nitrogen -14 Cross Section at Stellar Energies (proton Energies, Resonant Reaction)

    NASA Astrophysics Data System (ADS)

    Blackmon, Jeffery Curtis

    The isotopic abundance ratio 16O/17O has been shown to be a good probe of mass flow and mixing in stars. This ratio is sensitive to the depth of convective mixing which occurs on the giant branch and to the amount of nonconvective mixing occurring on the main sequence. The interpretation of recent observations of this ratio in red giants is limited by a large uncertainty in the value of the 17O(p, alpha)14N reaction rate. This reaction rate is dominated at stellar energies by a resonance at E_{rm x} = 5673 keV in the compound nucleus 18 F, whose strength was previously uncertain. We have carried out a measurement of the ^ {17}O(p,alpha)^{14 }N cross section at proton energies of 75 keV and 65 keV. Thick, high-purity rm Ta_2O _5 targets enriched to 77% ^ {17}O were used in conjunction with beam currents of 0.45 mA and large-solid-angle detectors. The background for the experiment was measured using targets of natural isotopic composition. The resonance peak was observed in the data collected at 75 keV, and we determined the proton width of the 5673 keV state to be 22 +/- 4 neV. This implies a rate for the 17O(p,alpha)^ {14}N reaction that is ten times greater than the typical rates used previously in stellar models.

  7. The implications of particle energy and acidic media on gross alpha and gross beta determination using liquid scintillation.

    PubMed

    Zapata-García, D; Llauradó, M; Rauret, G

    2012-04-01

    The interaction of humans with radioactivity present in the environment from natural and artificial sources necessitates an evaluation of its risk on human health. Gross alpha and gross beta activities can provide a rapid evaluation of the radioactive content of a sample and can be simultaneously determined by using liquid scintillation counters. However, calibration of the liquid scintillation counter is required and is affected by many factors, such as particle energy and the acidity of the media. This study investigates what effect the particle energy used for calibration has on misclassification and how to account for this misclassification in routine measurements. The variability in measurement produced by the final pH, as well as any acids used in sample treatment, was also studied. These results showed that the most commonly used acid for these types of analyses, HNO(3), produced a high amount of misclassifications at very low pH. The results improved when HCl was used to adjust the sample to low pH. PMID:22200448

  8. Dosimetry and radiobiological studies of automated alpha-particle irradiator.

    PubMed

    M V, Jyothish Babu; Shinde, Sanjay G; S, Sunil Kumar; Ali, Manjoor; Vasumathy, R; Kumar, Amit; Kolekar, R; Kumar, Manish; Nema, P; Bhagwat, P V; Pandey, Badri N

    2013-01-01

    Understanding the effect of alpha radiation on biological systems is an important component of radiation risk assessment and associated health consequences. However, due to the short path length of alpha radiation in the atmosphere, in vitro radiobiological experiments cannot be performed with accuracy in terms of dose and specified exposure time. The present paper describes the design and dosimetry of an automated alpha-particle irradiator named 'BARC BioAlpha', which is suitable for in vitro radiobiological studies. Compared to alpha irradiators developed in other laboratories, BARC BioAlpha has integrated computer-controlled movement of the alpha-particle source, collimator, and electronic shutter. The diaphragm blades of the electronic shutter can control the area (diameter) of irradiation without any additional shielding, which is suitable for radiobiological bystander studies. To avoid irradiation with incorrect parameters, a software interlock is provided to prevent shutter opening, unless the user-specified speed of the source and collimator are achieved. The dosimetry of the alpha irradiator using CR-39 and silicon surface barrier detectors showed that ~4 MeV energy of the alpha particle reached the cells on the irradiation dish. The alpha irradiation was also demonstrated by the evaluation of DNA double-strand breaks in human cells. In conclusion, 'BARC BioAlpha' provides a user-friendly alpha irradiation system for radiobiological experiments with a novel automation mechanism for better accuracy of dose and exposure time. PMID:24266413

  9. Radioimmunotherapy with alpha-particle emitting radionuclides.

    PubMed

    Zalutsky, M R; Pozzi, O R

    2004-12-01

    An important consideration in the development of effective strategies for radioimmunotherapy is the nature of the radiation emitted by the radionuclide. Radionuclides decaying by the emission of alpha-particles offer the possibility of matching the cell specific reactivity of monoclonal antibodies with radiation with a range of only a few cell diameters. Furthermore, alpha-particles have important biological advantages compared with external beam radiation and beta-particles including a higher biological effectiveness, which is nearly independent of oxygen concentration, dose rate and cell cycle position. In this review, the clinical settings most likely to benefit from alpha-particle radioimmunotherapy will be discussed. The current status of preclinical and clinical research with antibodies labeled with 3 promising alpha-particle emitting radionuclides - (213)Bi, (225)Ac, and (211)At - also will be summarized. PMID:15640792

  10. Analysis of radiation risk from alpha particle component of soalr particle events

    NASA Technical Reports Server (NTRS)

    Cucinotta, F. A.; Townsend, L. W.; Wilson, J. W.; Golightly, M. J.; Weyland, M.

    1994-01-01

    The Solar Particle Events (SPE) will contain a primary alpha particle component, representing a possible increase in the potential risk to astronauts during an SPE over the often studied proton component. We discuss the physical interactions of alpha particles important in describing the transport of these particles through spacecraft and body shielding. Models of light ion reactions are presented and their effects on energy and Linear Energy Transfer (LET) spectra in shielding are discussed. We present predictions of particle spectra, dose, and dose equivalent in organs of interest for SPE spectra typical of those occurring in recent solar cycles. The large events of solar cycle 19 are found to have substantial increase in biological risk from alpha particles, including a large increase in secondary neutron production from alpha particle breakup.

  11. Control of alpha-particle transport by ion cyclotron resonance heating

    SciTech Connect

    Chang, C.S.; Imre, K.; Weitzner, H.; Colestock, P. (Princeton Univ., NJ (United States). Plasma Physics Lab.)

    1990-12-01

    In this paper control of radial alpha-particle transport by using ion cyclotron range of frequency (ICRF) waves is investigated in a large-aspect-ratio tokamak geometry. Spatially inhomogeneous ICRF wave energy with properly selected frequencies and wave numbers can induce fast convective transports of alpha particles at the speed of order v{sub {alpha}} {approximately} (P{sub RF}/n{sub {alpha}}{epsilon}{sub 0}){rho}{sup p}, where R{sub RF} is the ICRF wave power density, n{sub {alpha}} is the alpha-particle density, {epsilon}{sub 0} is the alpha-particle birth energy, and {rho}{sub p} is the poloidal gyroradius of alpha particles at the birth energy. Application to International Thermonuclear Experimental Reactor (ITER) plasma is studied and possible antenna designs to control alpha-particle flux are discussed.

  12. Evaluation of silicon active pixel sensors for alpha particle detection

    NASA Astrophysics Data System (ADS)

    Maneuski, Dzmitry; Blue, Andrew; Hynds, Daniel; Mac Raighne, Aaron; O'Shea, Val

    2011-12-01

    Alpha particles can be used as a test stimulus offering several advantages for probing materials of micrometre thicknesses. In this work a silicon CMOS Active Pixel Sensor (APS) is evaluated for alpha particle detection and imaging. These devices can replace traditionally used solid-state track detectors, giving advantages of increased sensitivity, improved linearity and higher dynamic range. CMOS APSs offer high detection efficiency, low noise and digital readout. Qualitative and quantitative analysis of the back-illuminated back-thinned (BT) and standard sensor response to 5.5 MeV alpha particles is presented. Alpha particle detection efficiency was estimated and energy resolution was measured. Imaging capabilities were assessed and quantified. Cluster centroiding algorithms were implemented for image quality improvement.

  13. Variation in RBE for Survival of V79-4 Cells as a Function of Alpha-Particle (Helium Ion) Energy.

    PubMed

    Tracy, Bliss L; Stevens, David L; Goodhead, Dudley T; Hill, Mark A

    2015-07-01

    High linear energy transfer (LET) ? particles are important with respect to the carcinogenic risk associated with human exposure to ionizing radiation, most notably to radon and its progeny. Additionally, the potential use of alpha-particle-emitting radionuclides in radiotherapy is increasingly being explored. Within the body the emitted alpha particles slow down, traversing a number of cells with a range of energies and therefore with varying efficiencies at inducing biological response. The LET of the particle typically rises from between ~70-90 keV ?m(-1) at the start of the track (depending on initial energy) to a peak of ~237 keV ?m(-1) towards the end of the track, before falling again at the very end of its range. To investigate the variation in biological response with incident energy, a plutonium-238 alpha-particle irradiator was calibrated to enable studies with incident energies ranging from 4.0 MeV down to 1.1 MeV. The variation in clonogenic survival of V79-4 cells was determined as a function of incident energy, along with the relative variation in the initial yields of DNA double-strand breaks (DSB) measured using the FAR assay. The clonogenic survival data also extends previously published data obtained at the Medical Research Council (MRC), Harwell using the same cells irradiated with helium ions, with energies ranging from 34.9 MeV to 5.85 MeV. These studies were performed in conjunction with cell morphology measurements on live cells enabling the determination of absorbed dose and calculation of the average LET in the cell. The results show an increase in relative biological effectiveness (RBE) for cell inactivation with decreasing helium ion energy (increasing LET), reaching a maximum for incident energies of ~3.2 MeV and corresponding average LET of 131 keV ?m(-1), above which the RBE is observed to fall at lower energies (higher LETs). The effectiveness of single alpha-particle traversals (relevant to low-dose exposure) at inducing cell inactivation was observed to increase with decreasing energy to a peak of ~68% survival probability for incident energies of ~1.8 MeV (average LET of 190 keV ?m(-1)) producing ~0.39 lethal lesions per track. However, the efficiency of a single traversal will also vary significantly with cell morphology and angle of incidence, as well as cell type. PMID:26121227

  14. A Novel Experiment to Investigate the Attenuation of Alpha Particles in Air

    ERIC Educational Resources Information Center

    Andrews, D. G. H.

    2008-01-01

    A simple student experiment investigating dependence on air pressure of the attenuation of alpha particles in air is described. An equation giving the pressure needed to absorb all alpha particles of a given energy is derived from the Bethe-Bloch formula. Results are presented for the attenuation of alpha particles from americium 241 and radium…

  15. Alpha particle backscattering measurements used for chemical analysis of surfaces

    NASA Technical Reports Server (NTRS)

    Patterson, J. H.

    1967-01-01

    Alpha particle backscattering performs a chemical analysis of surfaces. The apparatus uses a curium source and a semiconductor detector to determine the energy spectrum of the particles. This in turn determines the chemical composition of the surface after calibration to known samples.

  16. {alpha}-particle production: Direct and compound contribution in the reaction {sup 7}Li+{sup 28}Si at near-barrier energies

    SciTech Connect

    Pakou, A.; Nicolis, N.G.; Papachristodoulou, C. [Department of Physics, The University of Ioannina, GR-45110 Ioannina (Greece); Rusek, K. [Department of Nuclear Reactions, The Andrzej Soltan Institute for Nuclear Studies, Hoza 69, PL-00-681 Warsaw (Poland); Alamanos, N.; Gillibert, A.; Pollacco, E.C. [DSM/DAPNIA CEA SACLAY, F-91191 Gif-sur-Yvette (France); Doukelis, G. [Technical Educational Institute of Athens, GR-12210 Athens (Greece); Kalyva, G.; Lagoyannis, A.; Perdikakis, G.; Spyrou, A.; Zarkadas, Ch. [National Research Center, Demokritos (Greece); Kokkoris, M. [National Technical University of Athens, Athens (Greece); Musumarra, A. [Dipartimento di Metodologie Fisiche e Chimiche per l'Ingegneria dell'Universita di Catania, Catania (Italy); Pierroutsakou, D. [INFN Sezione di Napoli, I-80125 Naples (Italy)

    2005-06-01

    The production of {alpha} particles in the {sup 7}Li+{sup 28}Si reaction was studied at near-barrier energies. Angular distributions were measured at four energies, namely 9, 10, 11, and 13 MeV. The data were treated in a statistical model and DWBA framework to disentangle the degree of competition between direct and compound channels in the reaction and its energy evolution near the barrier. It was found that whereas the compound mechanism is substantial, d transfer and possibly t transfer are the dominant mechanism at near-barrier energies. The influence of the reaction channels on the optical potential threshold anomaly is discussed.

  17. Actinium-225 in targeted alpha-particle therapeutic applications.

    PubMed

    Scheinberg, David A; McDevitt, Michael R

    2011-10-01

    Alpha particle-emitting isotopes are being investigated in radioimmunotherapeutic applications because of their unparalleled cytotoxicity when targeted to cancer and their relative lack of toxicity towards untargeted normal tissue. Actinium- 225 has been developed into potent targeting drug constructs and is in clinical use against acute myelogenous leukemia. The key properties of the alpha particles generated by 225Ac are the following: i) limited range in tissue of a few cell diameters; ii) high linear energy transfer leading to dense radiation damage along each alpha track; iii) a 10 day halflife; and iv) four net alpha particles emitted per decay. Targeting 225Ac-drug constructs have potential in the treatment of cancer. PMID:22202153

  18. The status of alpha-particle diagnostics

    SciTech Connect

    Young, K.M.; Johnson, D.W.

    1992-08-01

    There is a flurry of activity to complete alpha-particle diagnostics so that they can undergo some experimental testing in DT plasmas on JET or TFTR prior to implementation on ITER. Successful measurements of escaping charged fusion products have been made in DD plasmas, and the {alpha}-particle source can be well characterized by neutron profile measurement. These methods can be extrapolated to DT plasmas. Measurement of the confined {alpha}-particles requires a new technique. Collective Thomson scattering, methods involving charge-exchange interactions and nuclear reactions with impurities will be discussed. Some assessment is given of the capabilities of these techniques, bearing in mind the potential for their use in the physics phase of the ITER program.

  19. The status of alpha-particle diagnostics

    SciTech Connect

    Young, K.M.; Johnson, D.W.

    1992-01-01

    There is a flurry of activity to complete alpha-particle diagnostics so that they can undergo some experimental testing in DT plasmas on JET or TFTR prior to implementation on ITER. Successful measurements of escaping charged fusion products have been made in DD plasmas, and the {alpha}-particle source can be well characterized by neutron profile measurement. These methods can be extrapolated to DT plasmas. Measurement of the confined {alpha}-particles requires a new technique. Collective Thomson scattering, methods involving charge-exchange interactions and nuclear reactions with impurities will be discussed. Some assessment is given of the capabilities of these techniques, bearing in mind the potential for their use in the physics phase of the ITER program.

  20. Alternating current long range alpha particle detector

    DOEpatents

    MacArthur, D.W.; McAtee, J.L.

    1993-02-16

    An alpha particle detector, utilizing alternating currents, which is capable of detecting alpha particles from distinct sources. The use of alternating currents allows use of simpler ac circuits which, in turn, are not susceptible to dc error components. It also allows the benefit of gas gain, if desired. In the invention, a voltage source creates an electric field between two conductive grids, and between the grids and a conductive enclosure. Air containing air ions created by collision with alpha particles is drawn into the enclosure and detected. In some embodiments, the air flow into the enclosure is interrupted, creating an alternating flow of ions. In another embodiment, a modulated voltage is applied to the grid, also modulating the detection of ions.

  1. Alternating current long range alpha particle detector

    DOEpatents

    MacArthur, Duncan W. (Los Alamos, NM); McAtee, James L. (Los Alamos, NM)

    1993-01-01

    An alpha particle detector, utilizing alternating currents, whcih is capable of detecting alpha particles from distinct sources. The use of alternating currents allows use of simpler ac circuits which, in turn, are not susceptible to dc error components. It also allows the benefit of gas gain, if desired. In the invention, a voltage source creates an electric field between two conductive grids, and between the grids and a conductive enclosure. Air containing air ions created by collision with alpha particles is drawn into the enclosure and detected. In some embodiments, the air flow into the enclosure is interrupted, creating an alternating flow of ions. In another embodiment, a modulated voltage is applied to the grid, also modulating the detection of ions.

  2. Validating modeling assumptions of alpha particles in electrostatic turbulence

    NASA Astrophysics Data System (ADS)

    Wilkie, G. J.; Abel, I. G.; Highcock, E. G.; Dorland, W.

    2015-06-01

    To rigorously model fast ions in fusion plasmas, a non-Maxwellian equilibrium distribution must be used. In this work, the response of high-energy alpha particles to electrostatic turbulence has been analyzed for several different tokamak parameters. Our results are consistent with known scalings and experimental evidence that alpha particles are generally well confined: on the order of several seconds. It is also confirmed that the effect of alphas on the turbulence is negligible at realistically low concentrations, consistent with linear theory. It is demonstrated that the usual practice of using a high-temperature Maxwellian, while previously shown to give an adequate order-of-magnitude estimate of the diffusion coefficient, gives incorrect estimates for the radial alpha particle flux, and a method of correcting it in general is provided. Furthermore, we see that the timescales associated with collisions and transport compete at moderate energies, calling into question the assumption that alpha particles remain confined to a flux surface that is used in the derivation of the slowing-down distribution.

  3. SPECIAL TOPIC: Alpha particle physics experiments in the Tokamak Fusion Test Reactor

    NASA Astrophysics Data System (ADS)

    Zweben, S. J.; Budny, R. V.; Darrow, D. S.; Medley, S. S.; Nazikian, R.; Stratton, B. C.; Synakowski, E. J.; Taylor, G.; TFTR Group

    2000-01-01

    Alpha particle physics experiments were done on TFTR during its DT run from 1993 to 1997. These experiments utilized several new alpha particle diagnostics and hundreds of DT discharges to characterize the alpha particle confinement and wave-particle interactions. In general, the results from the alpha particle diagnostics agreed with the classical single particle confinement model in MHD quiescent discharges. The alpha loss due to toroidal field ripple was identified in some cases, and the low radial diffusivity inferred for high energy alphas was consistent with orbit averaging over small scale turbulence. Finally, the observed alpha particle interactions with sawteeth, toroidal Alfvén eigenmodes and ICRF waves were approximately consistent with theoretical modelling. What was learned is reviewed and what remains to be understood is identified.

  4. Optical appearance of alpha particle tracks in CR39 SSNTD

    Microsoft Academic Search

    K. N. Yu; H. H. W. Lee; A. W. T. Wong; Y. L. Law; S. F. L. Cheung; D. Nikezic; F. M. F. Ng

    2007-01-01

    A ray tracing method based on geometrical optics was used to study the tracks from alpha particles with different energies and with an incident angle of 50°. The transmission operation mode of the microscope is simulated. Considering the distribution of light intensities from the tracks, the mean and the 80% percentile gray levels from real experiments are proposed as quantitative

  5. Targeted alpha-particle immunotherapy for acute myeloid leukemia.

    PubMed

    Jurcic, Joseph G; Rosenblat, Todd L

    2014-01-01

    Because alpha-particles have a shorter range and a higher linear energy transfer (LET) compared with beta-particles, targeted alpha-particle immunotherapy offers the potential for more efficient tumor cell killing while sparing surrounding normal cells. To date, clinical studies of alpha-particle immunotherapy for acute myeloid leukemia (AML) have focused on the myeloid cell surface antigen CD33 as a target using the humanized monoclonal antibody lintuzumab. An initial phase I study demonstrated the safety, feasibility, and antileukemic effects of bismuth-213 ((213)Bi)-labeled lintuzumab. In a subsequent study, (213)Bi-lintuzumab produced remissions in some patients with AML after partial cytoreduction with cytarabine, suggesting the utility of targeted alpha-particle therapy for small-volume disease. The widespread use of (213)Bi, however, is limited by its short half-life. Therefore, a second-generation construct containing actinium-225 ((225)Ac), a radiometal that generates four alpha-particle emissions, was developed. A phase I trial demonstrated that (225)Ac-lintuzumab is safe at doses of 3 ?Ci/kg or less and has antileukemic activity across all dose levels studied. Fractionated-dose (225)Ac-lintuzumab in combination with low-dose cytarabine (LDAC) is now under investigation for the management of older patients with untreated AML in a multicenter trial. Preclinical studies using (213)Bi- and astatine-211 ((211)At)-labeled anti-CD45 antibodies have shown that alpha-particle immunotherapy may be useful as part conditioning before hematopoietic cell transplantation. The use of novel pretargeting strategies may further improve target-to-normal organ dose ratios. PMID:24857092

  6. Patient-specific alpha-particle dosimetry.

    PubMed

    Palm, Stig; Elgqvist, Jörgen; Jacobsson, Lars

    2011-10-01

    Alpha-particle therapy has received increased attention during the last few years because of the development of new targeting constructs and new labeling techniques and the availability of suitable ?-particle - emitting radionuclides. This work provides an overview of methods that have been used in clinical trials in estimating the absorbed dose to tumors and healthy tissue in patients following such ?-particle therapy. Similarities and differences compared to conventional therapies using ?Ż-particle emitters are presented. The specific challenges of establishing accurate dosimetry for ?- particles in the individual patient are also discussed, as is the effect that improved patient-specific dosimetry might have on the overall efficacy of this type of therapy. PMID:22202155

  7. Scaling of cross sections for K-electron capture by high-energy protons and alpha-particles from the multielectron atoms

    NASA Technical Reports Server (NTRS)

    Omidvar, K.

    1976-01-01

    Electron capture by protons from H, He, and the K-shell of Ar, and alpha particles from He are considered. It is shown that when a certain function of the experimental cross sections is plotted versus the inverse of the collision energy, at high energies the function falls on a straight line. At lower energies the function concaves up or down, depending on the charge of the projectile, the effective charge and the ionization potential of the electron that is being captured. The plot can be used to predict cross sections where experimental data are not available, and as a guide in future experiments. High energy scaling formulas for K-electron capture by low-charge projectiles are given.

  8. Alpha-particle-induced soft errors in dynamic memories

    Microsoft Academic Search

    T. C. May; M. H. Woods

    1979-01-01

    A new physical soft error mechanism in dynamic RAM's and CCD's is the upset of stored data by the passage of alpha particles through the memory array area. The alpha particles are emitted by the radioactive decay of uranium and thorium which are present in parts-per-million levels in packaging materials. When an alpha particle penetrates the die surface, it can

  9. ALPHA-PARTICLE RADIOBIOLOGICAL EXPERIMENTS USING THIN CR-39 DETECTORS

    E-print Network

    Yu, K.N.

    ALPHA-PARTICLE RADIOBIOLOGICAL EXPERIMENTS USING THIN CR-39 DETECTORS K. F. Chan1 , S. Y. M. Siu2 advantages of using CR-39 detectors as the cell-culture substrates in alpha-particle radiobiological the DNA damage in individual HeLa cervix cancer cells after alpha-particle irradiation. We prepared thin

  10. Gallium Nitride Room Temperature alpha Particle Detectors

    Microsoft Academic Search

    Min Lu; Guo-Guang Zhang; Kai Fu; Guo-Hao Yu

    2010-01-01

    Gallium Nitride (GaN) room temperature alpha particle detectors are fabricated and characterized, whose device structure is Schottky diode. The current-voltage (I - V) measurements reveal that the reverse breakdown voltage of the detectors is more than 200 V owing to the consummate fabrication processes, and that the Schottky barrier and ideal factor of the detectors are 0.64 eV and 1.02,

  11. Alpha particle losses from Tokamak Fusion Test Reactor deuterium-tritium plasmas

    SciTech Connect

    Darrow, D.S.; Zweben, S.J. [Princeton Univ., NJ (United States). Plasma Physics Lab.] [Princeton Univ., NJ (United States). Plasma Physics Lab.; Batha, S. [Fusion Physics and Technology, Torrance, CA (United States)] [Fusion Physics and Technology, Torrance, CA (United States)

    1996-01-01

    Because alpha particle losses can have a significant influence on tokamak reactor viability, the loss of deuterium-tritium alpha particles from the Tokamak Fusion Test Reactor (TFTR) has been measured under a wide range of conditions. In TFTR, first orbit loss and stochastic toroidal field ripple diffusion are always present. Other losses can arise due to magnetohydrodynamic instabilities or due to waves in the ion cyclotron range of frequencies. No alpha particle losses have yet been seen due to collective instabilities driven by alphas. Ion Bernstein waves can drive large losses of fast ions from TFTR, and details of those losses support one element of the alpha energy channeling scenario.

  12. The Radiation Chemistry of Aqueous Solutions. I. The Effect of Changing Linear Energy Transfer Along a Polonium alpha-Particle Track

    Microsoft Academic Search

    E. Collinson; F. S. Dainton; J. Kroh

    1962-01-01

    Absolute G values for chemical change when various aqueous solutions are irradiated with alpha-particles from an external polonium source have been determined for different fractions (x) of the alpha-particle track spent within the solution. G(Fe3+) for an aerated solution containing 1 mM ferrous ions and 0\\\\cdot1 N sulphuric acid decreases from 5\\\\cdot0 at x = 0\\\\cdot02 through a minimum value

  13. High speed imaging system in continuum and H-alpha at the Hida observatory for the study of high energy particles in solar flares

    NASA Astrophysics Data System (ADS)

    Ichimoto, K.; Kawate, T.; Yoshikazu, N.; Ishii, T.; Nagata, S.; Asai, A.; Masuda, S.; Kusano, K.; Yamamoto, T. T.; Minoshima, T.; Yokoyama, T.; Watanabe, K.

    2011-12-01

    Non-thermal particles are the fundamental ingredient of solar flares that carry the bulk energy released from the coronal magnetic fields and cause subsequent heating of the solar atmosphere to produce the radiation of wide range of electro-magnetic waves. The observations of hard X-ray and radio emissions suggest a rapid change of population of high energy particles with a time scale of sub-second. Flare kernels observed in visible lights, ex., H-alpha and continuum, show drastic evolutions in space and time during the rising phase of solar flares, and thought to be representing the locations of the precipitation of high energy particles into the chromosphere. Therefore the observations of flare kernels with high spatial and temporal resolutions provide valuable diagnosis of the distribution of high energy particles together with the information of connectivity of coronal magnetic fields. We developed a new high speed imaging system on a 25cm diameter telescope of the Solar Magnetic Activity Research Telescope (SMART) at the Hida observatory of Kyoto University. Images in H-alpha (width~3A) and continuum (6547A, width~10A) are recorded simultaneously with two CCD cameras with a spatial sampling of 0.2 arcsec/pix, field coverage of 344 arcsec x 258 arcsec, and a frame rate of 30fr/sec. Observation is conducted continuously by focusing a targeted active region every day, while only data sets that capture flare events are permanently stored for further analysis. The spatial and temporal evolutions of flare kernels thus obtained are combined with photospheric vector magnetic field taken by the SMART, SOT/Hinode and HMI/SDO, radio data by NoRH, hard X-ray image by RHESSI, and X-ray / UV images by SXT/Hinode and AIA/SDO to identify the instantaneous locations of high energy particles injection in the corona. In this paper we will present an overview of the observing system and its initial results. This work was carried out by the joint research program of the Solar-Terrestorial Environment Laboratory, Nagoya University.

  14. GaN-based PIN alpha particle detectors

    Microsoft Academic Search

    Guo Wang; Kai Fu; Chang-sheng Yao; Dan Su; Guo-guang Zhang; Jin-yan Wang; Min Lu

    GaN-based PIN alpha particle detectors are studied in this article. The electrical properties of detectors have been investigated, such as current–voltage (I–V) and capacitance–voltage (C–V). The reverse current of all detectors is in nA range applied at 30V, which is suitable for detector operation. The charge collection efficiency (CCE) is measured to be approximately 80% but the energy resolution is

  15. A global 2.5-dimensional three fluid solar wind model with alpha particles

    Microsoft Academic Search

    Bo Li; Xing Li; Nicolas Labrosse

    2006-01-01

    A global 2.5-dimensional three fluid solar wind model is presented. Two ion species, namely protons and alpha particles, are heated by an empirical energy flux while electrons are heated by the classical heat flux and Coulomb coupling with ions. It is found that for a reasonable relative speed between alpha particles and protons at 1 AU to be achieved, the

  16. Anomalous loss of DT alpha particles in the Tokamak Fusion Test Reactor

    SciTech Connect

    Herrmann, H.W.

    1997-09-01

    An escaping alpha collector probe has been developed for TFTR`s DT phase. Energy distributions of escaping alphas have been determined by measuring the range of {alpha}-particles implanted into nickel foils located within the alpha collector. Results at 1.0 MA of plasma current are in good agreement with predictions for first orbit alpha loss. Results at 1.8 MA, however, show a significant anomalous loss of partially thermalized alphas (in addition to the expected first orbit loss), which is not observed with the lost alpha scintillator detectors in DT plasmas, but does resemble the anomalous delayed loss seen in DD plasmas. None of the candidate explanations proposed thus far are fully consistent with the anomalous loss observations. An experiment designed to study the effect of plasma major radius shifts on {alpha}-particle loss has led to a better understanding of {alpha}-particle dynamics in tokamaks. Intuitively, one might suppose that confined marginally passing {alpha}-particles forced to move toward higher magnetic field during an inward major radius shift (i.e., compression) would mirror and become trapped particles, leading to increased alpha loss. Such an effect was looked for during the shift experiment, however, no significant changes in alpha loss to the 90{degree} lost alpha scintillator detector were observed during the shifts. It is calculated that the energy gained by an {alpha}-particle during the inward shift is sufficient to explain this result. However, an unexpected loss of partially thermalized {alpha}-particles near the passing/trapped boundary was observed to occur between inward and outward shifts at an intermediate value of plasma current (1.4 MA). This anomalous loss feature is not yet understood.

  17. Self-consistent study of the alpha particle driven TAE mode

    SciTech Connect

    Wu, Y.; White, R.B.

    1994-04-01

    The interaction of high energy particles with an Alfven eigenmode is investigated self-consistently by using a realistic kinetic dispersion relation. All important poloidal mode numbers and their radial mode profiles as calculated with the NOVA-K code are included. A Hamiltonian guiding center code is used to simulate the alpha particle motion. The numerical simulations include particle orbit width, nonlinear particle dynamics and the effects of the modes on the particles. Modification of the particle distribution leading to mode saturation is observed. Particle loss is limited to devices in which the alpha particle gyro radius is a significant fraction of the minor radius.

  18. Realizing the potential of the Actinium-225 radionuclide generator in targeted alpha particle therapy applications.

    PubMed

    Miederer, Matthias; Scheinberg, David A; McDevitt, Michael R

    2008-09-01

    Alpha particle-emitting isotopes have been proposed as novel cytotoxic agents for augmenting targeted therapy. Properties of alpha particle radiation such as their limited range in tissue of a few cell diameters and their high linear energy transfer leading to dense radiation damage along each alpha track are promising in the treatment of cancer, especially when single cells or clusters of tumor cells are targeted. Actinium-225 (225 Ac) is an alpha particle-emitting radionuclide that generates 4 net alpha particle isotopes in a short decay chain to stable 209 Bi, and as such can be described as an alpha particle nanogenerator. This article reviews the literature pertaining to the research, development, and utilization of targeted 225 Ac to potently and specifically affect cancer. PMID:18514364

  19. Targeted alpha particle immunotherapy for myeloid leukemia.

    PubMed

    Jurcic, Joseph G; Larson, Steven M; Sgouros, George; McDevitt, Michael R; Finn, Ronald D; Divgi, Chaitanya R; Ballangrud, Ase M; Hamacher, Klaus A; Ma, Dangshe; Humm, John L; Brechbiel, Martin W; Molinet, Roger; Scheinberg, David A

    2002-08-15

    Unlike beta particle-emitting isotopes, alpha emitters can selectively kill individual cancer cells with a single atomic decay. HuM195, a humanized anti-CD33 monoclonal antibody, specifically targets myeloid leukemia cells and has activity against minimal disease. When labeled with the beta-emitters (131)I and (90)Y, HuM195 can eliminate large leukemic burdens in patients, but it produces prolonged myelosuppression requiring hematopoietic stem cell transplantation at high doses. To enhance the potency of native HuM195 yet avoid the nonspecific cytotoxicity of beta-emitting constructs, the alpha-emitting isotope (213)Bi was conjugated to HuM195. Eighteen patients with relapsed and refractory acute myelogenous leukemia or chronic myelomonocytic leukemia were treated with 10.36 to 37.0 MBq/kg (213)Bi-HuM195. No significant extramedullary toxicity was seen. All 17 evaluable patients developed myelosuppression, with a median time to recovery of 22 days. Nearly all the (213)Bi-HuM195 rapidly localized to and was retained in areas of leukemic involvement, including the bone marrow, liver, and spleen. Absorbed dose ratios between these sites and the whole body were 1000-fold greater than those seen with beta-emitting constructs in this antigen system and patient population. Fourteen (93%) of 15 evaluable patients had reductions in circulating blasts, and 14 (78%) of 18 patients had reductions in the percentage of bone marrow blasts. This study demonstrates the safety, feasibility, and antileukemic effects of (213)Bi-HuM195, and it is the first proof-of-concept for systemic targeted alpha particle immunotherapy in humans. PMID:12149203

  20. Measurement of Alpha Particle Radioactivtiy in IC Device Packages

    Microsoft Academic Search

    E. S. Meieran; P. R. Engel; T. C. May

    1979-01-01

    Alpha particle radioactivity in package materials has been shown to cause soft errors in semiconductor devices. The particles are emitted by uranium and thorium decay sequence radioactive isotopes present as trace impurities in the raw materials used to make the package component parts. Chemical and radiation analys s techniques were correlated to alpha particle fluxes, which range in value from

  1. Simulation of Alpha Particles in Rotating Plasma Interacting with a Stationary Ripple

    SciTech Connect

    Abraham J. Fetterman and Nathaniel J. Fisch

    2011-01-11

    Superthermal ExB rotation can provide magnetohydrodynamic (MHD) stability and enhanced confinement to axisymmetric mirrors. However, the rotation speed has been limited by phenomena at end electrodes. A new prediction is that rotation might instead be produced using a magnetic ripple and alpha particle kinetic energy, in an extension of the alpha channeling concept. The interaction of alpha particles with the ripple results in visually interesting and practically useful orbits.

  2. Experimental determination of LR115 detector efficiency for exposure to alpha particles

    Microsoft Academic Search

    D Marocco; F Bochicchio

    2001-01-01

    The alpha particle detection efficiency of LR-115 detectors has been measured against alpha particle energy E and incidence angle ? (with respect to the normal to the detector surface), using an experimental apparatus with an 241Am alpha source and air in a pressure-controlled chamber as the degrading medium, and a spark-counter for counting tracks. About 200 LR-115 detectors were exposed

  3. Alpha particle effects on the internal kink and fishbone modes

    SciTech Connect

    Wu, Y.; Cheng, C.Z.; White, R.B. (Plasma Physics Laboratory, Princeton University, Princeton, New Jersey 08540 (United States))

    1994-10-01

    The effects of alpha particles on the internal kink and fishbone modes are studied analytically. The nonadiabatic contribution from untrapped alpha particles is negligible. Finite inverse aspect ratio, plasma [beta], and plasma shaping effects can significantly enhance the trapped particle drift reversal domain in the pitch angle space and reduce the bounce-averaged magnetic drift frequency. The decrease of the drift magnitude and drift reversal effects on the ideal kink mode is small, but the [beta][sub [alpha

  4. Alpha particle loss in the TFTR DT experiments

    SciTech Connect

    Zweben, S.J.; Darrow, D.S.; Herrmann, H.W. [and others

    1995-01-01

    Alpha particle loss was measured during the TFTR DT experiments using a scintillator detector located at the vessel bottom in the ion grad-B drift direction. The DT alpha particle loss to this detector was consistent with the calculated first-orbit loss over the whole range of plasma current I=0.6-2.7 MA. In particular, the alpha particle loss rate per DT neutron did not increase significantly with fusion power up to 10.7 MW, indicating the absence of any new ``collective`` alpha particle loss processes in these experiments.

  5. Epithermal and thermal alpha-particle transport and control

    SciTech Connect

    Miley, G.H.; Hu, S.C.; Varadarajan, V. (Illinois Univ., Urbana, IL (United States))

    1990-12-01

    In this paper alpha-particle ash accumulation in tokamaks and two possible ash control techniques are discussed. The effect of thermal alpha-particle ash accumulation on plasma performance is examined using a zero-dimensional analysis with profile corrections. Alpha-particle accumulation is shown to have serious effects on ignition requirements. An analytical model developed to predict the effect of sawtooth disruption on ash accumulation is discussed. The analytical results indicate that the sawtooth is effective when the temperature profile is parabolic or flatter. Alpha-particle ejection by a fishbone oscillation is envisaged to be helpful in ash control, and a model of the physics in a large-aspect-ratio approximation is discussed using an extended version of a Chen et al. formalism. The trapped particle destabilization of the internal kinks due to the alpha particles and a second hot-particle species is considered, and the expected oscillation frequency and growth rates are derived.

  6. Anomalous Loss of DT Alpha Particles in the Tokamak Fusion Test Reactor

    SciTech Connect

    Herrmann, Hans W.

    1997-06-01

    Princeton's Tokamak Fusion Test Reactor (TFTR) is the first experimental fusion device to routinely use tritium to study the deuterium-tritium (DT) fusion reaction,allowing the first systematic study of DT alpha particles in tokamak plasmas. A crucial aspect of alpha-particle physics is the fraction of alphas that escape from the plasma, particularly since these energetic particles can do severe damage to the first wall of a reactor. An escaping alpha collector probe has been developed for TFTR's DT phase. Energy distributions of escaping alphas have been determined by measuring the range of alpha-particles implanted into nickel foils located within the alpha collector. Results at 1.0 MA of plasma current are in good agreement with predictions for first orbit alpha loss. Results at 1.8 MA, however, show a significant anomalous loss of partially thermalized alphas (in addition to the expected first orbit loss), which is not observed with the lost alpha scintillator detectors in DT plasmas, but does resemble the anomalous "delayed" loss seen in DD plasmas. None of the candidate explanations proposed thus far are fully consistent with the anomalous loss observations. An experiment designed to study the effect of plasma major radius shifts on alpha-particle loss has led to a better understanding of alpha-particle dynamics in tokamaks. Intuitively, one might suppose that confined marginally passing alpha-particles forced to move toward higher magnetic field during an inward major radius shift (i.e. compression) would mirror and become trapped particles, leading to increased alpha loss. Such an effect was looked for during the shift experiment, however, no significant changes in alpha loss to the 90 degree lost alpha scintillator detector were observed during the shifts. It is calculated that the energy gained by an alpha-particle during the inward shift is sufficient to explain this result. However, an unexpected loss of partially thermalized alpha-particles near the passing/trapped boundary was observed to occur between inward and outward shifts at an intermediate value of plasma current (1.4 MA). This anomalous loss feature is not yet understood.

  7. Further explorations of the alpha-particle optical model potential at low energies for the mass range A=45-209

    E-print Network

    V. Avrigeanu; M. Avrigeanu; C. M?n?ilescu

    2014-10-28

    The recent high-precision measurements of alpha-particle induced reaction data below the Coulomb barrier (B) make possible the understanding of limits and possible improvement of a previous optical model potential (OMP) for alpha-particles on nuclei within the mass number range 45130. Moreover, underestimation of reaction cross sections for well-deformed nuclei is removed by using ~7% larger radius for the surface imaginary part of this spherical OMP. Improved input parameters based on recent independent data, particularly gamma-ray strength functions, but no empirical rescaling factor of the gamma and/or neutron widths have been involved within statistical model calculation of the corresponding (alpha,x) reaction cross sections.

  8. Use of /sup 3/He/sup + +/ ICRF minority heating to simulate alpha particle heating

    DOEpatents

    Post, D.E. Jr.; Hwang, D.Q.; Hovey, J.

    1983-11-16

    It is an object of the present invention to provide a better understanding of alpha particle behavior in a magnetically confined, energetic plasma. Another object of the present invention is to provide an improved means and method for studying and measuring the energy distribution of heated alpha particles in a confined plasma. Yet another object of the present invention is to permit detailed analysis of energetic alpha particle behavior in a magnetically confined plasma for use in near term fusion reactor experiments. A still further object of the present invention is to simulate energetic alpha particle behavior in a deuterium-tritium plasma confined in a fusion reactor without producing the neutron activation associated with the thus produced alpha particles.

  9. Measurement of the Internal Magnetic Field of Plasmas using an Alpha Particle Source

    SciTech Connect

    S.J. Zweben; D.S. Darrow; P.W. Ross; J.L. Lowrance; G. Renda

    2004-05-13

    The internal magnetic fields of plasmas can be measured under certain conditions from the integrated v x B deflection of MeV alpha particles emitted by a small radioactive source. This alpha source and large-area alpha particle detector would be located inside the vacuum vessel but outside the plasma. Alphas with a typical energy of 5.5 MeV (241Am) can reach the center of almost all laboratory plasmas and magnetic fusion devices, so this method can potentially determine the q(r) profile of tokamaks or STs. Orbit calculations, background evaluations, and conceptual designs for such a vxB (or ''AVB'') detector are described.

  10. GaN-based PIN alpha particle detectors

    NASA Astrophysics Data System (ADS)

    Wang, Guo; Fu, Kai; Yao, Chang-sheng; Su, Dan; Zhang, Guo-guang; Wang, Jin-yan; Lu, Min

    2012-01-01

    GaN-based PIN alpha particle detectors are studied in this article. The electrical properties of detectors have been investigated, such as current-voltage ( I- V) and capacitance-voltage ( C- V). The reverse current of all detectors is in nA range applied at 30 V, which is suitable for detector operation. The charge collection efficiency (CCE) is measured to be approximately 80% but the energy resolution is calculated to be about 40% mostly because the intrinsic layer is not sufficiently thick enough.

  11. Alpha particle effects on the internal kink and fishbone modes

    SciTech Connect

    Wu, Y.; Cheng, C.Z.; White, R.B.

    1994-06-01

    The effects of alpha particles on the internal kink and fishbone modes are studied analytically. The nonadiabatic contribution from untrapped alpha particles is negligible. Finite inverse aspect ratio, plasma {beta} and plasma shaping effects can significantly enhance the trapped particle drift reversal domain in the pitch angle space and reduce the bounce-averaged magnetic drift frequency. The drift reversal effect on the ideal kink mode is small, but the {beta}{sub {alpha}} threshold for the fishbone mode can be much lower than previously predicted. Moreover, the fishbone mode could be excited by alpha particles even when the plasma is stable in the ideal MHD limit. In addition, the ion diamagnetic drift frequency (finite ion Larmor radius effect) has a strong destabilizing effect on the fishbone mode when it is comparable with the trapped alpha averaged precessional drift frequency, even though it stabilizes the plasma in the ideal MHD limit.

  12. The Effects of Alpha Particle Confinement on Burning Plasma Tokamak Performance

    NASA Astrophysics Data System (ADS)

    Gormley, Robert P.

    In this thesis, three effects of alpha particle plasma interactions on the global performance of a fusion reactor are studied, namely, (i) the energy coupling efficiency of the fast alpha particles with the bulk plasma, (ii) the relationship between imperfect alpha energy coupling to the bulk plasma and the resultant alpha particle/helium ash fuel dilution; and (iii) the neoclassical bootstrap current induced by fusion born alpha particles calculated self-consistently with the plasma equilibrium. First, the ion drift kinetic equation for the high energy alpha particles is reduced from the exact five dimensional form to a two dimensional form in radius r and energy E (plus time t). The resulting slowing-down diffusion equation is solved by a multiple energy group method. A theoretically based anomalous diffusion coefficient D_sp{alpha}{an} is then introduced from a self-consistent alpha particle Alfven wave turbulence solution (by F. Gang), in which D_sp{alpha}{an } itself depends on the gradient in alpha density. The temporal and spatial behavior of eta_ alpha is analyzed for an ITER-CDA physics phase fusion reactor. We find that eta_ alpha can be as low as 0.95 depending on the plasma operating temperature. Next, the relationship between the alpha-particle power coupling efficiency and the actual alpha-particle power that is coupled with the bulk plasma is investigated, this time taking into account the concomitant helium ash accumulation. It is found that the coupled power varies less than linearly with eta_alpha and is, in fact, significantly depressed for eta_alpha near unity. Combining these effects with a thermal power balance shows that the high temperature "thermally stable" side of the ignition boundary is pushed toward lower temperatures if either D_alpha increases (which results in a lower eta_alpha) or the helium-ash confinement time lengthens. This is a consequence of strengthened fuel dilution and imperfect alpha power coupling. Implications on the thermal stability of a fusion reactor are also discussed. Lastly, we calculate the alpha particle induced bootstrap current produced, while retaining the effects of slowing-down drag, pitch-angle scattering, and arbitrary aspect ratio. The alpha drift kinetic equation is solved for the alpha bootstrap current density; and the resulting expression inserted into a simple cylindrical Ampere's Law. In addition, the alpha bootstrap current is more rigorously solved, self-consistently, with the full 2-D Grad-Shafranov equilibrium equations for three currently conceived tokamaks: TPX, ITER-CDA and ITER-EDA. In particular, the effect of varying plasma Zeff on the alpha bootstrap current is investigated. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617 -253-5668; Fax 617-253-1690.).

  13. Effect of alpha particles on Toroidal Alfven Eigenmodes

    SciTech Connect

    Berk, H.L.

    1992-11-01

    An overview is given of the analytic structure for the linear theory of the Toroidal Alfven Eigenmode (TAE), where multiple gap structures occur. A discussion is given of the alpha particle drive and the various dissipation mechanisms that can stabilize the system. A self-consistent calculation of the TAE mode, for a low-beta high-aspect-ratio plasma, indicates that though the alpha particle drive is comparable to the dissipation mechanisms, overall stability is still achieved for ignited ITER-like plasma. A brief discussion is given of the nonlinear theory for the TAE mode and how nonlinear alpha particle dynamics can be treated by mapping methods.

  14. Two-electron capture from helium by fast [alpha] particles

    SciTech Connect

    Belkic, D.; Mancev, I.; Mudrinic, M. (University of Stockholm, Atomic Physics, Frescativaegen 24, S-104 05 Stockholm (Sweden) Institute of Physics, P.O. Box 57, 11001 Belgrade (Yugoslavia) Department of Physics, University of Nis, P.O. Box 91, 18001 Nis (Yugoslavia))

    1994-05-01

    Two-electron capture from helium by fast [alpha] particles is investigated. Working within the four-body framework of scattering theory, we perform detailed computations for differential as well as total cross sections, by means of the second-order Born distorted-wave (BDW) approximation, and find good agreement with the available experimental data. We also report the results obtained by means of the continuum distorted-wave (CDW) method in both the four-body formalism and the independent-particle model. The former fails to reproduce the measurement, whereas the latter emerges as a satisfactory method for [alpha]-He double-charge exchange. The reported study of the electronic continuum intermediate states clearly indicates that double-charge exchange is remarkably sensitive to inclusion of these long-range Coulomb effects, even at incident energies at which the Thomas double scattering is completely unimportant. This is in sharp contrast to the familiar situation at the comparable energies encountered in treating single-electron transfer in ion-atom collisions.

  15. {alpha}-particle optical potentials for nuclear astrophysics (NA) and nuclear technology (NT)

    SciTech Connect

    Avrigeanu, V.; Avrigeanu, M. [Horia Hulubei National Institute for Physics and Nuclear Engineering, POBox MG-6, 077125 Magurele, Ilfov (Romania)

    2012-11-20

    The high precision of recent measurements for low-energy {alpha}-particle elastic-scattering as well as induced-reaction data makes possible the understanding of actual limits and possible improvement of the global optical model potentials parameters. Involvement of recent optical potentials for reliable description of both the elastic scattering and emission of {alpha}-particles, of equal interest for nuclear astrophysics (NA) and nuclear technology (NT) for fusion devices, is discussed in the present work.

  16. Physical aspects of precise spectrometry of alpha-particles with silicon pn-junction detectors

    Microsoft Academic Search

    E. Verbitskaya; V. Eremin; N. Strokan; J. Kemmer; B. Schmidt; J. von Borany

    1994-01-01

    Investigations of energy and charge losses have been carried out for silicon planar alpha-particle detectors. The detectors were manufactured by an advanced technology, using ion implantation and various annealing temperatures. A detailed analysis of the recombination processes in alpha-particle tracks with a high electron-hole density and a measurement procedure for the main parameters of charge carrier loss have been developed.

  17. High-spin particle states in 151Sm studied with the (alpha, 3He) reaction

    Microsoft Academic Search

    G. Lřvhřiden; J. R. Lien; J. C. Waddington; J. Rekstad; I. Espe; C. Gaarde; J. S. Larsen; S. van der Werf

    1981-01-01

    High-spin states have been located in 151Sm by means of the (alpha, 3He) reaction with 40 MeV alpha-particles. The scattered particles were momentum analyzed in a QMG\\/2 magnetic spectrometer and recorded in a position sensitive detector. Several high-spin states were observed in the energy range below 1.7 MeV excitation. The previously unknown strongly populated levels at 867 and 1480 keV

  18. Relative determination of W-values for alpha particles in tissue-equivalent and other gases

    Microsoft Academic Search

    G L Krieger; J W Baum; M N Varma; J L Beach

    1979-01-01

    W (the average energy to form an ion pair) for 5.4 MeV 241Am alpha particles in a Rossi-type tissue-equivalent (TE) gas, argon and methane was determined to an accuracy better than 0.2% using a new automated data handling system. A vibrating reed electrometer and current digitiser were used to measure the current produced by completely stopping the alpha particles in

  19. Alpha particle losses from Tokamak Fusion Test Reactor deuteriumtritium plasmas*

    E-print Network

    Alpha particle losses from Tokamak Fusion Test Reactor deuterium­tritium plasmas* D. S. Darrow, S. Petrov,e) C. K. Phillips, M. H. Redi, E. Ruskov,d) D. A. Spong,b) E. J. Strait,c) G. Taylor, R. B. White have a significant influence on tokamak reactor viability, the loss of deuterium­tritium alpha

  20. Full orbit calculation for lost alpha particle measurement on ITERa)

    NASA Astrophysics Data System (ADS)

    Funaki, D.; Isobe, M.; Nishiura, M.; Sato, Y.; Okamoto, A.; Kobuchi, T.; Kitajima, S.; Sasao, M.

    2008-10-01

    An orbit following calculation code with full gyromotion under the ITER magnetic field configuration has been developed to investigate escaping alpha particle orbits in ITER and to determine the geometrical arrangement for alpha particle detection. The code contained the full geometrical information of the first wall panels. It was carefully investigated whether an alpha particle escaping from the plasma through the last closed flux surface does not touch or intersect the first wall boundary before reaching the detection point. Candidates of blanket module modification have been studied to achieve effective measurement geometry for escaping alpha particle detection. The calculations showed that direct orbit loss and banana diffusion can be detected with a probe head recessed from the first wall surface.

  1. Full orbit calculation for lost alpha particle measurement on ITER

    SciTech Connect

    Funaki, D.; Isobe, M.; Nishiura, M.; Sato, Y.; Okamoto, A.; Kobuchi, T.; Kitajima, S.; Sasao, M. [Department of Quantum Energy Science, Tohoku University, Sendai 980-8579 (Japan)

    2008-10-15

    An orbit following calculation code with full gyromotion under the ITER magnetic field configuration has been developed to investigate escaping alpha particle orbits in ITER and to determine the geometrical arrangement for alpha particle detection. The code contained the full geometrical information of the first wall panels. It was carefully investigated whether an alpha particle escaping from the plasma through the last closed flux surface does not touch or intersect the first wall boundary before reaching the detection point. Candidates of blanket module modification have been studied to achieve effective measurement geometry for escaping alpha particle detection. The calculations showed that direct orbit loss and banana diffusion can be detected with a probe head recessed from the first wall surface.

  2. Q Values in alpha-Particle-Accompanied Ternary Fission

    Microsoft Academic Search

    N. Feather

    1968-01-01

    In relation to any mode of binary fission, there are nine possible ways in which the constituents of an alpha particle can be assembled using nucleons from one or both of the nascent binary fragments. Basing a definition of \\

  3. Alpha particle radiography with the CR39 nuclear track detector

    Microsoft Academic Search

    B. A. de Souza; S. C. Cabral; R. T. Lopes

    1995-01-01

    This work studies the alpha particle radiography technique, in conjunction with the CR-39 plastic track detector. The irradiations were made in the CV-28 cyclotron at IEN\\/CNEN\\/RJ, using a 7 MeV\\/nucleon alpha particle beam. All etches were performed by using a 6.25 N NaOH solution, at 70°C. The best etch time to obtain radiographs was determined. A calibration curve (Gray Levels

  4. Alpha particle effects on the internal kink modes

    SciTech Connect

    Wu, Yanlin; Cheng, C.Z.

    1994-08-01

    The {alpha}-particle effects on the internal kink mode stability are studied. Finite Grad-Shafranov Shift, plasma {beta}, and plasma shape can significantly enhance the trapped particle drift reversal domain in pitch angle space and reduce average magnetic drift frequency. The drift reversal effect on the ideal kink mode is small, but the {beta}{sub {alpha}} threshold for the fishbone mode can be much lower than previously predicted. In addition, the ion diamagnetic drift has a stronger destabilizing effect.

  5. Shielding of manned space vehicles against protons and alpha particles

    NASA Technical Reports Server (NTRS)

    Alsmiller, R. G., Jr.; Santoro, R. T.; Barish, J.; Claiborne, H. C.

    1972-01-01

    The available information on the shielding of manned space vehicles against protons and alpha particles is summarized. The emphasis is placed on shielding against Van Allen belt protons and against solar-flare protons and alpha particles, but information on shielding against galactic cosmic rays is also presented. The approximation methods for use by nonexperts in the space shielding field are those that are standard in the space shielding literature.

  6. Modification of alpha-particle emission spectrum in beam-injected deuterium-tritium plasmas

    SciTech Connect

    Matsuura, H.; Nakao, Y. [Department of Applied Quantum Physics and Nuclear Engineering, Kyushu University, Motooka, Fukuoka 819-0395 (Japan)

    2009-04-15

    The alpha ({alpha})-particle and neutron emission spectra in a deuterium-tritium plasma accompanied with neutral-beam-injection (NBI) heating are evaluated in a consistent way by solving the Boltzmann-Fokker-Planck equations for deuteron, triton, and {alpha}-particle simultaneously. It is shown that owing to the existence of non-Maxwellian tail component in fuel-ion distribution function due to NBI and/or nuclear elastic scattering, the generation rate of the energetic ({>=}4 MeV) {alpha}-particle increases significantly. When 20 MW intense deuterium beam with 1 MeV beam-injection energy is injected into an 800 m{sup 3} plasma (T{sub e}=10 keV, n{sub e}=6.2x10{sup 19} m{sup -3}), the enhancement of the fraction of the power carried by {alpha}-particles with energy above 4 (3.9) MeV to total {alpha}-particle power is almost twice (1.5 times) as much from the value for Gaussian distribution. A verification scenario for the modification of the emission spectrum by using the gamma ({gamma})-ray-generating {sup 9}Be({alpha},n{gamma}){sup 12}C reaction is also presented.

  7. Absorbed fractions for alpha-particles in tissues of cortical bone

    NASA Astrophysics Data System (ADS)

    Watchman, Christopher J.; Bolch, Wesley E.

    2009-10-01

    Bone-seeking alpha-particle emitting radionuclides are common health physics hazards. Additionally, they are under consideration as an option for therapeutic molecular radiotherapy applications. Current dose models do not account for energy or bone-site dependence as shown by alpha-particle absorbed fractions given in ICRP Publication 30. Energy-dependent, yet bone-site independent, alpha-particle absorbed fractions have been presented by the models of Stabin and Siegel (2003 Health Phys. 85 294-310). In this work, a chord-based computational model of alpha-particle transport in cortical bone has been developed that explicitly accounts for both the bone-site and particle-energy dependence of alpha-particle absorbed fractions in this region of the skeleton. The model accounts for energy deposition to three targets: cortical endosteum, haversian space tissues and cortical bone. Path length distributions for cortical bone given in Beddoe (1977 Phys. Med. Biol. 22 298-308) provided additional transport regions in the absorbed fraction calculation. Significant variations in absorbed fractions between different skeletal sites were observed. Differences were observed between this model and the absorbed fractions given in ICRP Publication 30, which varied by as much as a factor of 2.1 for a cortical bone surface source irradiating cortical endosteum.

  8. Alpha particle condensation in {sup 12}C and nuclear rainbow scattering

    SciTech Connect

    Ohkubo, S. [Department of Applied Science and Environment, Kochi Women's University, Kochi 780-8515 (Japan); Hirabayashi, Y. [Information Initiative Center, Hokkaido University, Sapporo 060-0811 (Japan)

    2008-05-12

    It is shown that the large radius of the Hoyle state of {sup 12}C with a dilute density distribution in an {alpha} particle condensate can be clearly seen in the shift of the rainbow angle (therefore the Airy minimum) to a larger angle in {alpha}+{sup 12}C rainbow scattering at the high energy region and prerainbow oscillations in {sup 3}He+{sup 12}C scattering at the lower energy region.

  9. Alpha Particle-Driven Toroidal Alfv en Eigenmodes in Tokamak Fusion Test Reactor Deuterium-Tritium Plasmas: Theory and

    E-print Network

    Alpha Particle-Driven Toroidal Alfv en Eigenmodes in Tokamak Fusion Test Reactor Deuterium-Tritium 26, 11 1984 Deuterium- Tritium plasmas are analyzed using the NOVA-K code C. Z. Cheng, Phys. Reports Deuterium-Tritium DT plasma, the fusion product alpha particles are born with an energy of 3:5 Me

  10. Use of .sup.3 He.sup.30 + ICRF minority heating to simulate alpha particle heating

    DOEpatents

    Post, Jr., Douglass E. (Belle Mead, NJ); Hwang, David Q. (Lawrencevill, NJ); Hovey, Jane (Plainsboro, NJ)

    1986-04-22

    Neutron activation due to high levels of neutron production in a first heated deuterium-tritium plasma is substantially reduced by using Ion Cyclotron Resonance Frequency (ICRF) heating of energetic .sup.3 He.sup.++ ions in a second deuterium-.sup.3 He.sup.++ plasma which exhibit an energy distribution and density similar to that of alpha particles in fusion reactor experiments to simulate fusion alpha particle heating in the first plasma. The majority of the fast .sup.3 He.sup.++ ions and their slowing down spectrum can be studied using either a modulated hydrogen beam source for producing excited states of He.sup.+ in combination with spectrometers or double charge exchange with a high energy neutral lithium beam and charged particle detectors at the plasma edge. The maintenance problems thus associated with neutron activation are substantially reduced permitting energetic alpha particle behavior to be studied in near term large fusion experiments.

  11. Alpha-Particle Condensation in Nuclear Systems

    NASA Astrophysics Data System (ADS)

    Schuck, P.; Funaki, Y.; Horiuchi, H.; Röpke, G.; Tohsaki, A.; Yamada, T.

    2013-02-01

    The onset of quartetting, i.e. ?-particle condensation, in symmetric and asymmetric nuclear matter is studied with the help of an in-medium modified four nucleon equation. It is found that at very low density quartetting wins over pairing, because of the strong binding of the ?-particles. The critical temperature can reach values up to around 8 MeV. The disappearance of ?-particles with increasing density, i.e. the Mott transition, is investigated. In finite nuclei the Hoyle state, that is the 02+ of 12C is identified as an '?-particle condensate' state. It is conjectured that such states also exist in heavier n?-nuclei, like 16O, 20Ne, etc. The sixth 0+ state in 16O is proposed as an analogue to the Hoyle state. The Gross-Pitaevski equation is employed to make an estimate of the maximum number of ? particles a condensate state can contain. Possible quartet condensation in other systems is discussed briefly.

  12. High resolution alpha particle detectors based on 4H-SiC epitaxial layer

    NASA Astrophysics Data System (ADS)

    Zat'ko, B.; Dubecký, F.; Šagátová, A.; Sedla?ová, K.; Ry?, L.

    2015-04-01

    We fabricated and characterized 4H-SiC Schottky diodes as a spectrometric detector of alpha particles. A thin blocking contact of Ni/Au (15 nm) was used to minimize the influence on alpha particles energy. Current-voltage characteristics of the detector were measured and a low current density below 0.3 nAcm?2 was observed at room temperature. 239Pu241Am244Cm was used as a source of alpha particles within the energy range between 5.1 MeV and 5.8 MeV for detector testing. The charge collection efficiency close to 100 % at reverse bias exceeding 50 V was determined. The best spectrometric performance shows a pulse height spectrum at a reverse bias of 200 V giving an energy resolution of 0.25 % in the full width and half maximum for 5.486 MeV of 241Am.

  13. Nuclear alpha-particle condensates or the emperor's new clothes

    E-print Network

    Zinner, N T

    2007-01-01

    We assess the validity of recent claims for appearance of alpha-cluster condensation in nuclei. We compare different measures of condensation and show that few-body nuclear condensates are ill-defined. We use the quantality condition of Mottelson, separating solid and mean-field structures, to emphasize the conflict between localization and condensate formation. We explore the connection between Ikeda diagrams, linear chains and Tonks-Girardeau gasses. We show that no new information is contained in approximations of nuclear states as alpha-cluster condensates. Condensate states of more than three alpha-particles do not exist due to couplings to other degrees of freedom.

  14. Selective flow path alpha particle detector and method of use

    DOEpatents

    Orr, Christopher Henry (Sellafield, Seascale, Cumbria, GB); Luff, Craig Janson (Sellafield, Seascale, Cumbria, GB); Dockray, Thomas (Sellafield, Seascale, Cumbria, GB); Macarthur, Duncan Whittemore (P.O. Box 1663, Los Alamos, NM 87545)

    2002-01-01

    A method and apparatus for monitoring alpha contamination are provided in which ions generated in the air surrounding the item, by the passage of alpha particles, are moved to a distant detector location. The parts of the item from which ions are withdrawn can be controlled by restricting the air flow over different portions of the apparatus. In this way, detection of internal and external surfaces separately, for instance, can be provided. The apparatus and method are particularly suited for use in undertaking alpha contamination measurements during the commissioning operations.

  15. Mutagenic effects of alpha particles in normal human skin fibroblasts

    SciTech Connect

    Chen, D.J.; Carpenter, S.; Hanks, T. [Los Alamos National Lab., NM (United States)

    1992-12-31

    Alpha-irradiation to the bronchial airways from inhaled radon progeny increases the risk of developing lung cancer. The molecular mechanism of radon-induced lung cancer is not clear, but one of the most important genetic effects of ionizing radiation is the induction of gene mutation. Mutations, especially those associated with visible chromosome abnormalities in humans, have been associated with cancer. Therefore, our objective is to use a well-defined model system to determine the mutagenic potential of alpha particles in normal human skin cells and to define this action at the molecular level. Normal human skin fibroblasts were irradiated with alpha particles (3.59 MeV, LET 115 keV {mu}m{sup {minus}1}) emitted from the decay of {sup 238}Pu. Mutagenicity was determined at the X-linked hypoxanthine guanine phosphoribosyl transferase (HPRT) locus. Results from this study indicate that beta particles were more efficient in mutation induction than gamma rays. Based on the initial slopes of the dose-response curves, the RBE for mutation is about 8 for alpha particles. HPRT-deficient mutants which are resistant to 6-thioguanine have been isolated and analyzed by the Southern blot technique. To date, we have characterized 69 gamma-ray-induced and 195 alpha-particle-induced HPRT-deficient mutants. Our data indicate that more than 50% of all gamma-ray-induced mutants have band patterns identical to that observed for the normal structural HPRT gene, whereas the remaining mutants (45%) contain either a rearrangement, partial deletion, or total deletion of the HPRT gene. In contrast, only 30% of alpha-particle-induced human HPRT mutants contain a normal Southern blot pattern, and about 50% indicate total deletion of the HPRT gene. Our results support the notion that high-LET radiation produces more unrepaired or misrepaired DNA damage than do gamma rays.

  16. Investigation of thermal and slowing-down alpha particles on JET using charge-exchange spectroscopy

    Microsoft Academic Search

    M. von Hellermann; W. Mandl; H. P. Summers; A. Boileau; R. Hoekstra; F. J. de Heer; J. Frieling

    1991-01-01

    Thermal alpha particles are observed in JET during helium discharges using spectral emission in He II (n=4 to 3) near 4685 AA following charge transfer reactions along the path of the neutral deuterium heating beams. New and reappraised He22\\/H charge transfer cross-sections are presented. The effects of cross-section energy dependence on temperatures, velocities and absolute densities deduced from thermal alpha

  17. AlphaRad, a new integrated CMOS System-On-Chip for high efficiency alpha particle counting.

    E-print Network

    Paris-Sud XI, Université de

    1 AlphaRad, a new integrated CMOS System-On-Chip for high efficiency alpha particle counting. D * corresponding author : daniel.husson@ires.in2p3.fr Abstract An integrated System-on-Chip (SoC) has been designed; #12;2 Key words: Solid state detectors; System-on-chip; Alpha particles; Neutrons. The field

  18. Alpha Particles Play a Relatively Minor Role in Magnetized Target Fusion Systems

    SciTech Connect

    Ryutov, D.D. [Lawrence Livermore National Laboratory (United States)

    2002-03-15

    Two problems related to alpha particle physics in magnetized target fusion (MTF) systems are briefly discussed. First, we evaluate the pressure and density of alpha particles under the assumption that they are perfectly confined and have a classical slowing-down distribution. It turns out that because of a comparatively low plasma temperature in MTF systems, the relative pressure and density of alpha particles are more than an order of magnitude less than in fusion reactors based on ITER-type tokamaks. Therefore, one may expect that even in the extreme case of a perfect confinement of alpha particles, their presence will have a much weaker (than in the case of tokamaks) effect on plasma stability and transport. Second, we discuss the kinetics of plasma burn under the opposite extreme assumption that all the alpha particles are instantaneously lost, without leaving any energy in a plasma. It turns out that even in this case, the plasma energy yield in batch-burn systems is only weakly affected by burnout effects.

  19. CR-SA hysteresis phenomenon on the basis of alpha-particle satellite data

    NASA Astrophysics Data System (ADS)

    Dorman, L. I.; Iucci, N.; Parisi, M.; Villoresi, G.

    We analyzed satellite 5-min data on alpha-particle fluxes in energy intervals 60-160 MeV, 160-260 MeV and 330-500 MeV during January 1986 -- May 2000. In the first we excluded periods with great CR increases caused by particle acceleration in solar flare events. Then we determined monthly averaged fluxes as well as 5 months and 11 months smooth averaged data. We corrected these data on drift effects according to the procedure described in Dorman (2004) in dependence of alpha-particle energies. Corrected on drifts alpha-particles fluxes we compare with expected according to convection-diffusion modulation for different values of supposed dimension of the modulation region (measured by time of solar wind propagation from the Sun to the boundary of this region Xo from 1 to 60 av. months; described in Dorman, 2004). By this way we can determine Xomax, at what the correlation coefficient reaches the maximum value. Then it can be determined the dimension of modulation region (with taking into account the influence of nonlinear processes on the solar wind speed in the outer Heliosphere according to Le Roux and Fichtner, 1997), the radial diffusion coefficient and transport path as well as expected alpha-particle intensity out of the modulation region and absolute alpha-particle modulation (relative to the alpha-particle intensity level in the interstellar space). References: Dorman L.I. ``Expected relative role of drift and convection-diffusion mechanisms in global small energy cosmic ray modulation''. Paper, submitted on the Session D1.2 of COSPAR 2004. Le Roux J.A. and H. Fichtner ``The influence of pickup, anomalous, and galactic cosmic ray protons on the structure of the heliospheric shock: a self consistent approach'', Astrophys. J, 477, L115-L118, 1997.

  20. Effects of alpha-particles on survival and chromosomal aberrations in human mammary epithelial cells

    NASA Technical Reports Server (NTRS)

    Durante, M.; Grossi, G. F.; Gialanella, G.; Pugliese, M.; Nappo, M.; Yang, T. C.

    1995-01-01

    We have studied the radiation responses of a human mammary epithelial cell line, H184B5 F5-1 M/10. This cell line was derived from primary mammary cells after treatment with chemicals and heavy ions. The F5-1 M/10 cells are immortal, density-inhibited in growth, and non-tumorigenic in athymic nude mice and represent an in vitro model of the human epithelium for radiation studies. Because epithelial cells are the target of alpha-particles emitted from radon daughters, we concentrated our studies on the efficiency of alpha-particles. Confluent cultures of M/10 cells were exposed to accelerated alpha-particles [beam energy incident at the cell monolayer = 3.85 MeV, incident linear energy transfer (LET) in cell = 109 keV/microns] and, for comparison, to 80 kVp x-rays. The following endpoints were studied: (1) survival, (2) chromosome aberrations at the first postirradiation mitosis, and (3) chromosome alterations at later passages following irradiation. The survival curve was exponential for alpha-particles (D0 = 0.73 +/- 0.04 Gy), while a shoulder was observed for x-rays (alpha/beta = 2.9 Gy; D0 = 2.5 Gy, extrapolation number 1.6). The relative biological effectiveness (RBE) of high-LET alpha-particles for human epithelial cell killing was 3.3 at 37% survival. Dose-response curves for the induction of chromosome aberrations were linear for alpha-particles and linearquadratic for x-rays. The RBE for the induction of chromosome aberrations varied with the type of aberration scored and was high (about 5) for chromosome breaks and low (about 2) for chromosome exchanges.(ABSTRACT TRUNCATED AT 250 WORDS).

  1. Modelling and Dosimetry for Alpha-Particle Therapy

    PubMed Central

    Sgouros, George; Hobbs, Robert F.; Song, Hong

    2015-01-01

    As a consequence of the high potency and short range of alpha-particles, radiopharmaceutical therapy with alpha-particle emitting radionuclides is a promising treatment approach that is under active pre-clinical and clinical investigation. To understand and predict the biological effects of alpha-particle radiopharmaceuticals, dosimetry is required at the micro or multi-cellular scale level. At such a scale, highly non-uniform irradiation of the target volume may be expected and the utility of a single absorbed dose value to predict biological effects comes into question. It is not currently possible to measure the pharmacokinetic input required for micro scale dosimetry in humans. Accordingly, pre-clinical studies are required to provide the pharmacokinetic data for dosimetry calculations. The translation of animal data to the human requires a pharmacokinetic model that links macro- and micro-scale pharmacokinetics thereby enabling the extrapolation of micro-scale kinetics from macroscopic measurements. These considerations along with a discussion of the appropriate physical quantity and related units for alpha-particle radiopharmaceutical therapy are examined in this review. PMID:22201712

  2. Theory of energetic/alpha particle effects on magnetohydrodynamic modes in tokamaks

    SciTech Connect

    Chen, L.; White, R.B.; Rewoldt, G.; Colestock, P.; Rutherford, P.H.; Chen, Y.P.; Ke, F.J.; Tsai, S.T.; Bussac, M.N.

    1989-01-01

    The presence of energetic particles is shown to qualitatively modify the stability properties of ideal as well as resistive magnetohydrodynamic (MHD) modes in tokamaks. Specifically, we demonstrate that, consistent with highpower ICRF heating experiments in JET, high energy trapped particles can effectively stabilize the sawtooth mode, providing a possible route to stable high current tokamak operation. An alternative stabilization scheme employing barely circulating energetic particles is also proposed. Finally, we present analytical and numerical studies on the excitations of high-n MHD modes via transit resonances with circulating alpha particles. 14 refs., 3 figs.

  3. Alpha-particle physics in the tokamak fusion test reactor DT experiment

    Microsoft Academic Search

    S. J. Zweben; V. Arunasalam; S. H. Batha; R. V. Budny; C. E. Bush; S. Cauffman; C. S. Chang; Z. Chang; C. Z. Cheng; D. S. Darrow; R. O. Dendy; H. H. Duong; N. J. Fisch; E. D. Fredrickson; R. K. Fisher; R. J. Fonck; G. Y. Fu; V. Goloborod'ko; N. Gorelenkov; R. J. Hawryluk; R. Heeter; W. W. Heidbrink; H. W. Herrmann; M. Herrmann; D. W. Johnson; J. Machuzak; R. Majeski; K. M. McGuire; G. McKee; S. S. Medley; H. E. Mynick; R. Nazikian; M. P. Petrov; M. H. Redi; S. Reznik; J. Rogers; G. Schilling; D. A. Spong; J. D. Strachan; B. C. Stratton; E. Synakowski; G. Taylor; S. Wang; R. B. White; K. L. Wong; V. Yavorski

    1997-01-01

    A summary is presented of recent alpha-particle experiments on the tokamak fusion test reactor. Alpha particles are generally well confined in MHD-quiescent discharges, and alpha heating of electrons has been observed. The theoretically predicted toroidicity-induced Alfvén eigenmode has been seen in discharges of <= 1 MW of alpha power, but only in plasmas with weak magnetic shear.

  4. High energy particle astronomy.

    NASA Technical Reports Server (NTRS)

    Buffington, A.; Muller, R. A.; Smith, L. H.; Smoot, G. F.

    1972-01-01

    Discussion of techniques currently used in high energy particle astronomy for measuring charged and neutral cosmic rays and their isotope and momentum distribution. Derived from methods developed for accelerator experiments in particle physics, these techniques help perform important particle astronomy experiments pertaining to nuclear cosmic ray and gamma ray research, electron and position probes, and antimatter searches.

  5. Enhanced retention of the alpha-particle-emitting daughters of Actinium-225 by liposome carriers.

    PubMed

    Sofou, Stavroula; Kappel, Barry J; Jaggi, Jaspreet S; McDevitt, Michael R; Scheinberg, David A; Sgouros, George

    2007-01-01

    Targeted alpha-particle emitters hold great promise as therapeutics for micrometastatic disease. Because of their high energy deposition and short range, tumor targeted alpha-particles can result in high cancer-cell killing with minimal normal-tissue irradiation. Actinium-225 is a potential generator for alpha-particle therapy: it decays with a 10-day half-life and generates three alpha-particle-emitting daughters. Retention of (225)Ac daughters at the target increases efficacy; escape and distribution throughout the body increases toxicity. During circulation, molecular carriers conjugated to (225)Ac cannot retain any of the daughters. We previously proposed liposomal encapsulation of (225)Ac to retain the daughters, whose retention was shown to be liposome-size dependent. However, daughter retention was lower than expected: 22% of theoretical maximum decreasing to 14%, partially due to the binding of (225)Ac to the phospholipid membrane. In this study, Multivesicular liposomes (MUVELs) composed of different phospholipids were developed to increase daughter retention. MUVELs are large liposomes with entrapped smaller lipid-vesicles containing (225)Ac. PEGylated MUVELs stably retained over time 98% of encapsulated (225)Ac. Retention of (213)Bi, the last daughter, was 31% of the theoretical maximum retention of (213)Bi for the liposome sizes studied. MUVELs were conjugated to an anti-HER2/neu antibody (immunolabeled MUVELs) and were evaluated in vitro with SKOV3-NMP2 ovarian cancer cells, exhibiting significant cellular internalization (83%). This work demonstrates that immunolabeled MUVELs might be able to deliver higher fractions of generated alpha-particles per targeted (225)Ac compared to the relative fractions of alpha-particles delivered by (225)Ac-labeled molecular carriers. PMID:17935286

  6. Non-equilibrium effects in alpha-particle-induced reactions in light, medium and heavy nuclei up to 120 MeV

    Microsoft Academic Search

    J. Rama Rao; A. V. Mohan Rao; S. Mukherjee; R. Upadhyay; N. L. Singh; S. Agarwal; L. Chaturvedi; P. P. Singh

    1987-01-01

    Alpha-particle-induced reactions on the target elements vanadium, niobium and holmium were investigated in the energy range from 10 to 120 MeV, using the foil stack activation technique and Ge(Li) gamma-ray spectroscopy. The excitation functions of six reactions of the ( alpha , xn) type were studied, of which three reactions 51V( alpha ,n)54Mn, 165Ho( alpha ,2n)167Tm and 165Ho( alpha ,4n)165Tm

  7. Quality factors for alpha particles emitted in tissue

    NASA Technical Reports Server (NTRS)

    Borak, Thomas B.; Chatterjee, A. (Principal Investigator)

    2002-01-01

    A concept of a mean or dose averaged quality factor was defined in ICRP Publication 26 using relationships for quality factor as a function of LET. The concept of radiation weighting factors, wR, was introduced in ICRP Publication 60 in 1990. These are meant to be generalized factors that modify absorbed dose to reflect the risk of stochastic effects as a function of the quality of the radiation incident on the body or emitted by radioactivity within the body. The values of wr are equal to 20 for all alpha particles externally or internally emitted. This note compares the dose averaged quality factor for alpha particles originating in tissue using the old and revised recommendations for quality factor as a function of LET. The dose averaged quality factor never exceeds 20 using the old recommendations and is never less than 20 with the revised recommendations.

  8. Influence of Magnolol on the bystander effect induced by alpha-particle irradiation

    E-print Network

    Yu, K.N.

    Influence of Magnolol on the bystander effect induced by alpha-particle irradiation T.P.W. Wong, Hong Kong a r t i c l e i n f o Keywords: Bystander effect Alpha-particle CHO cells Magnolol a b s t r a c t In this work, the influence of Magnolol on the bystander effect in alpha-particle irradiated

  9. An alpha particle instrument with alpha, proton, and X-ray modes for planetary chemical analyses

    NASA Technical Reports Server (NTRS)

    Economou, T. E.; Turkevich, A. L.

    1976-01-01

    The interaction of alpha particles with matter is employed in a compact instrument that could provide rather complete in-situ chemical analyses of surfaces and thin atmospheres of extraterrestrial bodies. The instrument is a miniaturized and improved version of the Surveyor lunar instrument. The backscattering of alpha particles and (alpha, p) reactions provide analytical data on the light elements (carbon-iron). An X-ray mode that detects the photons produced by the alpha sources provides sensitivity and resolution for the chemical elements heavier than about silicon. The X-rays are detected by semiconductor detectors having a resolution between 150 and 250 eV at 5.9 keV. Such an instrument can identify and determine with good accuracy 99 percent of the atoms (except hydrogen) in rocks. For many trace elements, the detecting sensitivity is a few ppm. Auxiliary sources could be used to enhance the sensitivities for elements of special interest. The instrument could probably withstand the acceleration involved in semi-hard landings.

  10. Distributions of Alpha Particles Escaping to the Wall because of Sawtooth Oscillations in TFTR

    SciTech Connect

    Kolesnichenko, Ya.I.; Lutsenko, V.V.; White, R.B.; Yakovenko, Yu.V., Zweben, S.J.

    1998-11-01

    It has been observed experimentally in deuterium-tritium shots of the Tokamak Fusion Test Reactor (TFTR) that crashes of sawtooth oscillations may result in very inhomogeneous flux of alpha particles to the wall. Namely, measurements with four detectors installed at the wall at 20°, 45°, 60°, and 90° below the midplane of the torus have shown that the alpha flux to the wall is strongly peaked at the 20° and 90° detectors and on the noise level at the 45° detector. To explain this phenomenon, both theoretical analysis and numerical simulation have been carried out. It is concluded that the "crash-induced prompt loss," i.e., the orbital loss of marginally trapped particles arising because of the crash-induced orbit transformation of circulating particles, is responsible for the flux to the 90° and 60° detectors, whereas the crash-induced stochastic diffusion of moderately trapped particles explains the large signal at the 20° detector. The calculated poloidal distributions of the integral alpha flux are in reasonable agreement with experimental data. In addition to the integral flux, the flux of particles with given energy was calculated. The energy spectrum of the escaping particles has also been calculated, which can be used for diagnostics of the crash type.

  11. The effects of alpha particle irradiation on stainless steel 

    E-print Network

    Shipp, John Douglas

    1999-01-01

    (1000), Pu 239, Pu 240, Am 241 +, deveta(1000), dev Jz, devflux, avgSae(1000) +, avgeta(1000), avg Jz, avgflux, stdSae(1000) +, stdeta(1000), std Jz, stdflux, particle(10), avgparticle, stdparticle, +sumparticle, Elow, Elo(10), devElo, stdElo, sum...THE EFFECTS OF ALPHA PARTICLE IRRADIATION ON STAINLESS STEEL A Thesis by JOHN DOUGLAS SHIPP Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE...

  12. Destabilization of low mode number Alfven modes in a tokamak by energetic or alpha particles

    SciTech Connect

    Tsang, K. T.; Sigmar, D. J.; Whitson, J. C.

    1980-12-01

    With the inclusion of finite Larmor radius effects in the shear Alfven eigenmode equation, the continuous Alfven spectrum, which has been extensively discussed in ideal magnetohydrodynamics, is removed. Neutrally stable, discrete radial eigenmodes appear in the absence of sources of free energy and dissipation. Alpha (or energetic) particle toroidal drifts destabilize these modes, provided the particles are faster than the Alfven speed. Although the electron Landu resonance contributes to damping, a stability study of the parametric variation of the energy and the density scale length of the energetic particles shows that modes with low radial mode numbers remain unstable in most cases. Since the alpha particles are concentrated in the center of the plasma, this drift-type instability suggests anomalous helium ash diffusion. Indeed, it is shown that stochasticity of alpha orbits due to the overlapping of radially neighboring Alfven resonances is induced at low amplitudes, e/sub i//sup approx./phi/T/sub i/ greater than or equal to 0.05, implying a diffusion coefficient D/sub r//sup ..cap alpha../ greater than or equal to 4.4 x 10/sup 3/cm/sup 2//s.

  13. Variation of the track etch rates of alpha-particle trajectory in PADC

    NASA Astrophysics Data System (ADS)

    Zaki, M. F.; Hegazy, T. M.; Seddik, U.; Morsy, A. A.

    2005-01-01

    The formation of etched tracks in solid-state nuclear track detectors is usually described by assuming an unequivocal correlation of the etch-rate ratio with the energy loss of charged particles. For alpha particles, this assumption could be verified within the scatter of the experimental data. In this article, the dependence of the depth (x) on the track etch rate (V-T) was determined experimentally by track length measurement. It is found that the track etch rate as a function of the depth within the detector follows the Bragg curve. The track etch rate has been found to be described by a generalization of the restricted energy loss, in good approximation along the trajectories of alpha particles.

  14. Alpha particle transport in the presence of toroidal driftwaves

    NASA Astrophysics Data System (ADS)

    Nishimura, Y.; Huang, B.; Cheng, C. Z.

    2013-10-01

    Transport of fusion born ? particles is investigated in the presence of poloidally mode coupled ballooning type driftwaves. The onset of orbit stochasticity is understood as an overlapping of electric islands produced by the driftwaves, whose overlapping threshold is lower for the thermal particles than for the ? particles (high energy particles). For the trapped particles, transport is determined by the particles' sensitive response to the fluctuation at the banana tip where the parallel velocity decreases drastically. Time dependent turbulent signals (finite ?* effects) give rise to the shift of the resonant radial locations, which again is larger for the thermal particles than the high energy particles. The transport process is influenced by the microscopic structure of the islands, which deviates from the Gaussian process. This work is supported by National Science Council of Taiwan, NSC 100-2112-M-006-021-MY3 and NCKU Top University Project.

  15. Gene expression profile of human lymphocytes exposed to (211)At alpha particles.

    PubMed

    Turtoi, A; Brown, I; Schläger, M; Schneeweiss, F H A

    2010-08-01

    In this study, the Whole Human Genome 44K DNA microarray assay was used for the first time to obtain gene expression profiles in human peripheral blood lymphocytes 2 h after exposure (in suspension) to 6.78 MeV mean energy alpha particles from extracellular (211)At. Lymphocytes were exposed to fluences of 0.3-9.6 x 10(6) alpha particles/cm(2) [corresponding to mean absorbed alpha-particle doses (D(alpha)) of 0.05-1.60 Gy] over 30 min. Significantly modulated expression was identified in 338 early-response genes. Up-regulated expression was evident in 183 early-response genes, while the remaining 155 were down-regulated. Over half of the up-regulated genes and 40% of the down-regulated genes had a known biological process related primarily to cell growth and maintenance and cell communication. Genes associated with cell death were found only in the up-regulated genes and those with development only in the down-regulated genes. Eight selected early-response genes that displayed a sustained up- or down-regulation (CD36, HSPA2, MS4A6A, NFIL3, IL1F9, IRX5, RASL11B and SULT1B1) were further validated in alpha-particle-irradiated lymphocytes of two human individuals using the TaqMan(R) RT-qPCR technique. The results confirmed the observed microarray gene expression patterns. The expression modulation profiles of IL1F9, IRX5, RASL11B and SULT1B1 genes demonstrated similar trends in the two individuals studied. However, no significant linear correlation between increasing relative gene expression and the alpha-particle dose was evident. The results suggest the possibility that a panel of genes that react to alpha-particle radiation does exist and that they merit further study in a greater number of individuals to determine their possible value regarding alpha-particle biodosimetry. PMID:20681779

  16. Alpha-particle Measurements Needed for Burning Plasma Experiments

    SciTech Connect

    Kenneth M. Young

    2001-09-26

    The next major step in magnetic fusion studies will be the construction of a burning plasma (BP) experiment where the goals will be to achieve and understand the plasma behavior with the internal heating provided by fusion-generated alpha particles. Two devices with these physics goals have been proposed: the International Thermonuclear Experimental Reactor (ITER) and the Fusion Ignition Research Experiment (FIRE). Extensive conceptual design work for the instrumentation to try to meet the physics demands has been done for these devices, especially ITER. This article provides a new look at the measurements specifically important for understanding the physics aspects of the alpha particles taking into account two significant events. The first is the completion of physics experiments on the Joint European Torus (JET) and the Tokamak Fusion Test Reactor (TFTR) with deuterium-tritium fueling with the first chances to study alpha physics and the second is the realization that relatively compact plasmas, making use of advanced tokamak plasma concepts, are the most probable route to burning plasmas and ultimately a fusion reactor.

  17. Beams of protons and alpha particles greater than approximately 30 keV/charge from the earth's bow shock

    NASA Technical Reports Server (NTRS)

    Scholer, M.; Ipavich, F. M.; Gloeckler, G.

    1981-01-01

    Two beamlike particle events (30 keV/charge to 160 keV/charge) upstream of the earth's bow shock have been investigated with the Max-Planck-Institut/University of Maryland ultralow energy and charge analyzer on ISEE 1. These beams consist of protons as well as of alpha particles, and the spectra are generally steep and are decreasing with increasing energy. During one event the spectra of both protons and alpha particles have a maximum at approximately 65 keV/charge. During these events, the interplanetary magnetic field through the satellite position was almost tangent to the bow shock, and application of the theory of acceleration predicts acceleration of a solar wind particle up to 60 keV/nucleon in a single reflection. The observation of reflected protons as well as alpha particles has implications for the physical reflection process usually not discussed in acceleration theories.

  18. Particle-Mesh Simulations of the Lyman-Alpha Forest

    E-print Network

    A. Meiksin; M. White

    2000-08-15

    Numerical hydrodynamical simulations have proven a successful means of reproducing many of the statistical properties of the Lyman-Alpha forest as measured in high redshift quasar spectra. Pseudo-hydrodynamical methods based only on simulating the dark matter component have been claimed to yield a comparable level of success. We investigate the degree to which two pseudo-methods, with and without allowing for a pseudo-gas pressure, are able to match the predictions of fully hydrodynamical plus dark matter simulations. We also address the requirements for convergence to the statistics of the spectra and the inferred properties of the Lyman-Alpha forest as a function of resolution and box size. Generally we find it is possible to reach agreement with full hydrodynamic simulations at the 10% level in the cumulative distributions of the flux and absorption line parameter statistics for readily achievable particle and grid numbers, but difficult to do much better.

  19. Cryogenic microcalorimeter system for ultra-high resolution alpha-particle spectrometry

    SciTech Connect

    Rabin, Michael W [Los Alamos National Laboratory; Hoover, Andrew S [Los Alamos National Laboratory; Bacrania, Mnesh K [Los Alamos National Laboratory; Croce, Mark P [Los Alamos National Laboratory; Hoteling, N J [Los Alamos National Laboratory; Lamont, S P [Los Alamos National Laboratory; Plionis, A A [Los Alamos National Laboratory; Dry, D E [Los Alamos National Laboratory; Ullom, J N [NIST; Bennett, D A [NIST; Horansky, R [NIST; Kotsubo, V [NIST; Cantor, R [STAR CRYOELECTRONICS

    2009-01-01

    Microcalorimeters have been shown to yield unsurpassed energy resolution for alpha spectrometry, up to 1.06 keV FWHM at 5.3 MeV. These detectors use a superconducting transition-edge sensor (TES) to measure the temperature change in an absorber from energy deposited by an interacting alpha particle. Our system has four independent detectors mounted inside a liquid nitrogen/liquid helium cryostat. An adiabatic demagnetization refrigerator (ADR) cools the detector stage to its operating temperature of 80 mK. Temperature regulation with {approx}15 uK peak-to-peak variation is achieved by PID control of the ADR. The detectors are voltage-biased, and the current signal is amplified by a commercial SQUID readout system and digitized for further analysis, This paper will discuss design and operation of our microcalorimeter alpha spectrometer, and will show recent results.

  20. The $\\alpha-\\alpha$ fishbone potential revisited

    E-print Network

    Day, J P; Elhanafy, M; Smith, E; Woodhouse, R; Papp, Z

    2011-01-01

    The fishbone potential of composite particles simulates the Pauli effect by nonlocal terms. We determine the $\\alpha-\\alpha$ fishbone potential by simultaneously fitting to two-$\\alpha$ resonance energies, experimental phase shifts and three-$\\alpha$ binding energies. We found that essentially a simple gaussian can provide a good description of two-$\\alpha$ and three-$\\alpha$ experimental data without invoking three-body potentials.

  1. Radiolytic gas production in the alpha particle degradation of plastics

    SciTech Connect

    Reed, D.T.; Hoh, J.; Emery, J. (Argonne National Lab., IL (United States)); Hobbs, D. (Westinghouse Savannah River Co., Aiken, SC (United States))

    1992-01-01

    Net gas generation due to alpha particle irradiation of polyethylene and polyvinyl chloride was investigated. Experiments were performed in an air environment at 30, 60, and 100{degree}C. The predominant radiolytic degradation products of polyethylene were hydrogen and carbon dioxide with a wide variety of trace organic species noted. Irradiation of polyvinyl chloride resulted in the formation of HCl in addition to the products observed for polyethylene. For both plastic materials, a strong enhancement of net yields was noted at 100{degree}C.

  2. Radiolytic gas production in the alpha particle degradation of plastics

    SciTech Connect

    Reed, D.T.; Hoh, J.; Emery, J. [Argonne National Lab., IL (United States); Hobbs, D. [Westinghouse Savannah River Co., Aiken, SC (United States)

    1992-05-01

    Net gas generation due to alpha particle irradiation of polyethylene and polyvinyl chloride was investigated. Experiments were performed in an air environment at 30, 60, and 100{degree}C. The predominant radiolytic degradation products of polyethylene were hydrogen and carbon dioxide with a wide variety of trace organic species noted. Irradiation of polyvinyl chloride resulted in the formation of HCl in addition to the products observed for polyethylene. For both plastic materials, a strong enhancement of net yields was noted at 100{degree}C.

  3. Ionisation cross sections of Cd, Sn, Te, I and Ba for protons and alpha particles

    Microsoft Academic Search

    L. Avaldi; M. Milazzo; G. Trivia; I. V. Mitchell

    1983-01-01

    K-shell X-ray production cross sections of 48Cd, 50Sn, 52Te, 53I and 56Ba have been measured for alpha particles with energies between 2.2 and 2.8 MeV. In addition, production cross sections for 52Te have been measured for protons between 1.6 and 3 MeV. The values have been compared with the earlier experiments and with the theoretical predictions given by four different

  4. Profiles and parameters of tracks in the LR115 detector irradiated with alpha particles

    E-print Network

    Yu, K.N.

    Profiles and parameters of tracks in the LR115 detector irradiated with alpha particles D. Nikezic particles. Some differences between the behavior of CR39 and LR115 detectors are discussed. Track parameters have been calculated and plotted for the CR39 detector irradiated with alpha particles [11]. Another

  5. $\\alpha $-Attractors: Planck, LHC and Dark Energy

    E-print Network

    Carrasco, John Joseph M; Linde, Andrei

    2015-01-01

    We develop four-parameter supergravity models of inflation and dark energy, constrained so that ${\\delta\\rho\\over \\rho}$, $n_s$ and the cosmological constant $\\Lambda $ take their known observable values, but where the mass of gravitino $m_{3/2}$ and the tensor-to-scalar ratio $r$ are free parameters. We focus on generalized cosmological $\\alpha$-attractor models, with logarithmic Kahler potentials, a nilpotent goldstino and spontaneously broken supersymmetry at the de Sitter minimum. The future data on B-modes will specify the parameter $\\alpha$, measuring the geometry of the Kahler, manifold. The string landscape idea for dark energy is supported in these models via an incomplete cancellation of the universal positive goldstino and negative gravitino contribution. The scale of SUSY breaking M related to the mass of gravitino in our models is a controllable parameter, independent on the scale of inflation, it will be constrained by LHC data and future collider Energy-frontier experiments.

  6. Design, spectrum measurements and simulations for a 238Pu alpha-particle irradiator for bystander effect and genomic instability experiments.

    PubMed

    Hakanen, Arvi; Siiskonen, Teemu; Pöllänen, Roy; Kosunen, Antti; Turunen, Asko; Belyakov, Oleg

    2006-08-01

    Design, spectrum measurements and simulations for an alpha-particle irradiator for bystander effect and genomic instability experiments are presented. Measured alpha-particle energy spectra were used to confirm the characteristics of the source of the irradiator specified by the manufacturer of the source. The spectra were measured in vacuum with a high-resolution spectrometer and simulated with an AASI Monte Carlo code. As a next step, we simulated alpha-particle energy spectra at the target plane of the irradiator for three different source-to-target distances. In these simulations, helium was used as the medium between the source and the exit window of the irradiator; its pressure and temperature corresponded to those of the ambient air. Mean energies and full-widths at half-maximum (FWHM) were calculated for the three different helium gas tracks. PMID:16618543

  7. Skeletal dosimetry models for alpha-particles for use in molecular radiotherapy

    NASA Astrophysics Data System (ADS)

    Watchman, Christopher J.

    Molecular radiotherapy is a cancer treatment methodology whereby a radionuclide is combined with a biologically active molecule to preferentially target cancer cells. Alpha-particle emitting radionuclides show significant potential for use in molecular radiotherapy due to the short range of the alpha-particles in tissue and their high rates of energy deposition. Current radiation dosimetry models used to assess alpha emitter dose in the skeleton were developed originally for occupational applications. In medical dosimetry, individual variability in uptake, translocation and other biological factors can result in poor correlation of clinical outcome with marrow dose estimates determined using existing skeletal models. Methods presented in this work were developed in response to the need for dosimetry models which account for these biological and patient-specific factors. Dosimetry models are presented for trabecular bone alpha particle dosimetry as well as a model for cortical bone dosimetry. These radiation transport models are the 3D chord-based infinite spongiosa transport model (3D-CBIST) and the chord-based infinite cortical transport model (CBICT), respectively. Absorbed fraction data for several skeletal tissues for several subjects are presented. Each modeling strategy accounts for biological parameters, such as bone marrow cellularity, not previously incorporated into alpha-particle skeletal dosimetry models used in radiation protection. Using these data a study investigating the variability in alpha-particle absorbed fractions in the human skeleton is also presented. Data is also offered relating skeletal tissue masses in individual bone sites for a range of ages. These data are necessary for dose calculations and have previously only been available as whole body tissue masses. A revised 3D-CBIST model is also presented which allows for changes in endosteum thickness to account for revised target cell location of tissues involved in the radiological induction of bone cancer. In addition, new data are presented on the location of bone-marrow stem cells within the marrow cavities of trabecular bone of the pelvis. All results presented in this work may be applied to occupational exposures, but their greatest utility lies in dose assessments for alpha-emitters in molecular radiotherapy.

  8. Mutagenic effects of a single and an exact number of alpha particles in mammalian cells

    NASA Technical Reports Server (NTRS)

    Hei, T. K.; Wu, L. J.; Liu, S. X.; Vannais, D.; Waldren, C. A.; Randers-Pehrson, G.

    1997-01-01

    One of the main uncertainties in risk estimation for environmental radon exposure using lung cancer data from underground miners is the extrapolation from high- to low-dose exposure where multiple traversal is extremely rare. The biological effects of a single alpha particle are currently unknown. Using the recently available microbeam source at the Radiological Research Accelerator Facility at Columbia University, we examined the frequencies and molecular spectrum of S1- mutants induced in human-hamster hybrid (A(L)) cells by either a single or an exact number of alpha particles. Exponentially growing cells were stained briefly with a nontoxic concentration of Hoechst dye for image analysis, and the location of individual cells was computer-monitored. The nucleus of each cell was irradiated with either 1,2,4, or 8 alpha particles at a linear energy transfer of 90 keV/microm consistent with the energy spectrum of domestic radon exposure. Although single-particle traversal was only slightly cytotoxic to A(L) cells (survival fraction approximately 0.82), it was highly mutagenic, and the induced mutant fraction averaged 110 mutants per 10(5) survivors. In addition, both toxicity and mutant induction were dose-dependent. Multiplex PCR analysis of mutant DNA showed that the proportion of mutants with multilocus deletions increased with the number of particle traversals. These data provide direct evidence that a single a particle traversing a nucleus will have a high probability of resulting in a mutation and highlight the need for radiation protection at low doses.

  9. A self-consistent theory of collective alpha particle losses induced by Alfvenic turbulence

    SciTech Connect

    Biglari, H. [Princeton Univ., NJ (United States). Plasma Physics Lab.; Diamond, P.H. [California Univ., San Diego, La Jolla, CA (United States). Dept. of Physics

    1992-01-01

    The nonlinear dynamics of kinetic Alfven waves, resonantly excited by energetic ions/alpha particles, is investigated. It is shown that {alpha}-particles govern both linear instability and nonlinear saturation dynamics, while the background MHD turbulence results only in a nonlinear real frequency shift. The most efficient saturation mechanism is found to be self-induced profile modification. Expressions for the fluctuation amplitudes and the {alpha}-particle radial flux are self-consistently derived. The work represents the first self-consistent, turbulent treatment of collective {alpha}-particle losses by Alfvenic fluctuations.

  10. An SiC\\/GaN Detector\\/Front-End Detection System for High-Resolution Alpha-Particle Spectroscopy

    Microsoft Academic Search

    A. Pullia; G. Bertuccio; D. Maiocchi; S. Caccia; F. Zocca

    2008-01-01

    An alpha-particle spectrometer has been assembled, consisting of an epitaxial 50 mum thick 4H silicon carbide (SiC) detector connected to a gallium-nitride (GaN) high-electron mobility transistor (HEMT) used as input transistor of the front-end electronics. The depleted layer of the SiC diode detector was sufficient to stop all alpha particles in the 4.8-MeV to 5.8-MeV energy range. An excellent energy

  11. Dark Energy from $\\alpha$-Attractors

    E-print Network

    Linder, Eric V

    2015-01-01

    A class of inflation theories called $\\alpha$-attractors has been investigated recently with interesting properties interpolating between quadratic potentials, the Starobinsky model, and an attractor limit. Here we examine their use for late time cosmic acceleration. We generalize the class and demonstrate how it can interpolate between thawing and freezing dark energy, and reduce the fine tuning of initial conditions, allowing $w\\approx-1$ for a prolonged period or as a de Sitter attractor.

  12. Alpha particle transport in the presence of ballooning type electrostatic driftwaves

    NASA Astrophysics Data System (ADS)

    Nishimura, Y.; Huang, B.; Cheng, C. Z.

    2015-07-01

    Employing Hamiltonian mechanics, the transport of fusion born alpha particles in the presence of driftwave turbulence is investigated. An analytical turbulence model based on the toroidal drift eigenmode is employed for guiding center orbit-following calculations. It is shown that high energy particles are less susceptible to driftwave turbulence. The passing particle transport is due to overlapping of guiding center electric islands whose widths are inversely proportional to the square root of the parallel velocity. For trapped particles, through a coordinate transformation from the poloidal angle and the parallel velocity to the action-angle variables, the resonance between the bounce motion and the toroidal precession motion, which can cause secondary island formation in the phase space, is demonstrated.

  13. A CMOS integrated pulse mode alpha-particle counter for application in radon monitoring

    SciTech Connect

    Ahmed, A.; Walkey, D.J.; Tarr, N.G. [Carleton Univ., Ottawa, Ontario (Canada). Dept. of Electronics] [Carleton Univ., Ottawa, Ontario (Canada). Dept. of Electronics

    1997-06-01

    A custom integrated circuit for detecting alpha particles for application in the monitoring of radon has been designed and tested. The design uses the reverse-biased well to a substrate capacitance of a p-n junction in a conventional CMOS process as a sense capacitor for incident alpha particles. A simple CMOS inverter is used as an analog amplifier to detect the small potential change induced by an alpha-particle strike on the sense capacitor. The design was implemented in a 1.2-{micro}m conventional CMOS process with a sense capacitor area of 110 {micro}m{sup 2}. Tests carried out under vacuum conditions using a calibrated {sup 241}Am alpha-particle source showed an output voltage swing of {ge}2.0 V for an alpha event. The detector is also shown to have good immunity to noise and high-quantum efficiency for alpha particles.

  14. Relative biological effectiveness of alpha particles at radon exposure.

    PubMed

    Zhukovsky, M; Bastrikova, N; Vasilyev, A

    2015-06-01

    The relative biological effectiveness (RBE) of alpha particles at radon exposure is estimated by comparison of radiation risks at external gamma exposure and radon exposure in different situations. For external gamma exposure, the BEIR VII model of radiation risk assessment was used. For occupational and indoor radon exposure, models such as BEIR VI, WISMUT, Tomasek's and combined miners population were considered. It was demonstrated that RBE values are strongly dependent on models of radiation risk assessment used for RBE calculation, sex of exposed peoples and age at the exposure. The average values of RBE in dependence on model of risk assessment choice are in the range from 1.5 to 12.0 for males and in the range from 0.34 to 2.7 for females. PMID:25979745

  15. Low energy particle composition. [energy spectra, particle emission - solar flares

    NASA Technical Reports Server (NTRS)

    Gloeckler, G.

    1975-01-01

    The energy spectra and composition of the steady or 'quiet-time' particle flux, whose origin is unknown was studied. Particles and photons which are associated with solar flares or active regions on the sun were also studied. Various detection techniques used to measure the composition and energy spectra of low energy particles are discussed. Graphs of elemental abundance and energy spectra are given.

  16. Energetic/alpha particle effects on MHD modes and transport

    SciTech Connect

    Cheng, C.Z.; Budny, R. [Princeton Univ., NJ (United States). Plasma Physics Lab.; Chen, L. [Univ. of California, Irvine, CA (United States). Dept. of Physics

    1995-01-01

    A nonvariational kinetic-MHD stability code (NOVA-K) has been employed to study TAE stability in TFRR D-T and DIII-D experiments and to achieve understanding of TAE instability drive and damping mechanism. Reasonably good agreement between theory and experiment has been obtained. In these experiments the dominant damping mechanism is due to both the thermal ion Landau damping and/or the beam ion Landau damping. Based on ITER EDA parameters, the TAE modes are expected to be unstable in normal ITER operations. Energetic particle transport has been studied using a test particle code (ORBIT). Energetic particle loss scales linearly with the TAE mode amplitude and can be large for TFRR and DIII-D for {delta}B{sub r}/B > 10{sup {minus}4} due to large banana orbit. From quasi-linear (ORBIT) and nonlinear kinetic-MHD (MH3D-K) simulations the saturation of TAE modes is due to nonlinear wave particle trapping and energetic particle profile modification in both radial and energy space. Finally, a convective bucket transport mechanism by MHD waves with time-dependent frequency is presented. Based on the energy-selective characteristics of the bucket transport mechanism, undesirable particles such as helium ash can be removed from the plasma core efficiently.

  17. Alpha-Particle/Proton Differential Flow in the Solar Wind: Implications for Plasma Heating, Azimuthal Flow, and the Parker Spiral Magnetic Field

    NASA Astrophysics Data System (ADS)

    Verscharen, D.; Bourouaine, S.; Chandran, B. D. G.

    2014-12-01

    Protons and alpha particles in the fast solar wind are only weakly collisional and exhibit a number of non-equilibrium features, including temperature anisotropies and relative drifts along the direction of the background magnetic field. Two mechanisms have been proposed for limiting differential flow between alpha particles and protons: plasma instabilities and the rotational force. Both mechanisms decelerate the alpha particles - for example, the Alfvén/ion-cyclotron and fast-magnetosonic/whistler instabilities limit the drift velocity to a value comparable to the Alfvén speed, which decreases with increasing heliocentric distance r. However, while plasma instabilities transform bulk-flow kinetic energy into heat and plasma waves, the rotational force does not. We present an analytic expression for the rate Qflow at which energy is released when alpha particles are decelerated by instabilities. We find that Qflow becomes zero at a critical radius r=rcrit, where rcrit is between 1.5 AU and 2 AU in the fast solar wind in the ecliptic plane, and rcrit increases with increasing heliographic latitude. We show that instabilities control the deceleration of alpha particles at ralpha particles at r>rcrit. We compare the value of Qflow at ralpha particles deduced from in-situ measurements of fast-wind streams from the Helios and Ulysses spacecraft. We find that Qflow exceeds the empirical heating rate for alpha particles at r<1 AU. We conclude that the continuous energy input from alpha-particle deceleration at ralpha-particle drift for the azimuthal flow velocities of the ions and for the Parker spiral magnetic field.

  18. Study of the beta-delayed alpha-particle emission of 16N

    NASA Astrophysics Data System (ADS)

    Zhao, Z.; France, R. H., III; Lai, K. S.; Gai, M.; Wilds, E. L.; Kryger, R. A.; Winger, J. A.; Beard, K. B.

    1993-07-01

    The beta-delayed alpha-particle emission of 16N has been studied, with 16N nuclei produced using 80 MeV/nucleon 18O beams on 9Be targets. The 16N secondary nuclei were mass analyzed and separated from the reaction products using the Michigan State University A1200 isotope separator. A detector array, including four thin surface barrier detectors, a p-i-n diode, a Ge gamma-ray detector, and a two-dimensional position sensitive parallel plate avalanche counter, was used for implantation and study of the separated nuclei. A beta-decay branching ratio of (1.3+/-0.3)×10-5 to the 1- state at 9.6 MeV and a centroid of 2.35+/-0.05 MeV for the beta-delayed alpha-particle emission were measured. These results are essential for the analysis of a high sensitivity measurement at Yale University of the low-energy beta-delayed alpha-particle emission of 16N, and for understanding the 12C(?,?)16O reaction in the helium burning process in massive stars.

  19. Damage of EUV optical coatings induced by alpha-particles bombardment

    NASA Astrophysics Data System (ADS)

    Pelizzo, M. G.; Zuccon, S.; Napolitani, E.; Corso, A. J.; Zuppella, P.; Tessarolo, E.; Nardello, M.; Gerlin, F.; Naletto, G.; Fineschi, S.; Antonucci, E.

    2014-09-01

    Future solar missions will investigate the Sun from very close distances and optical components are constantly exposed to low energy ions irradiation. Single layer thin films as well as extreme ultraviolet multilayer coatings have been exposed to low energy alpha particles (4keV). In order to change the total dose accumulated, for each ion fluency the time of exposure was varied. The experiment was carried out considering typical doses accumulated during the ESA Solar Orbiter mission. Results show that ion implantation affects the performances of both single and multilayer coatings.

  20. Electron-hole pair generation in SiC high-temperature alpha particle detectors

    NASA Astrophysics Data System (ADS)

    Garcia, Timothy R.; Kumar, Ashutosh; Reinke, Benjamin; Blue, Thomas E.; Windl, Wolfgang

    2013-10-01

    We demonstrate alpha-particle detection in an n-type 4H-SiC Schottky diode detector up to a temperature of 500 °C using an Am-241 disc source. The measured spectra were used to calculate the electron-hole pair creation energy in 4H-SiC and its non-bandgap contribution, which are both found to decrease with increasing temperature. The full width at half maximum (FWHM) of the measured alpha-energy peaks was found to increase exponentially with temperature due to an exponential increase of leakage current. For our measurement system, above 300 °C, where the leakage current was 10-6 A, this increase exceeded the FWHM at room temperature.

  1. Electron-Hole Pair Generation in SiC High-Temperature Alpha Particle Detectors

    E-print Network

    Garcia, Timothy R; Reinke, Benjamin T; Blue, Thomas E; Windl, Wolfgang E

    2013-01-01

    We demonstrate alpha-particle detection in an n-type 4H-SiC Schottky diode detector up to an unprecedented temperature of 500 {\\deg}C using an Am-241 disc source. The measured spectra were used to calculate the electron-hole pair creation energy in 4H-SiC and its non-bandgap contribution, which are both found to decrease with increasing temperature. The full width at half maximum (FWHM) of the measured alpha-energy peaks was found to increase exponentially with temperature due to an exponential increase of leakage current. For our measurement system, above 300 {\\deg}C, where the leakage current was 10-6 A, this increase exceeded the FWHM at room temperature.

  2. Deceleration of Alpha Particles in the Solar Wind by Instabilities and the Rotational Force: Implications for Heating, Azimuthal Flow, and the Parker Spiral Magnetic Field

    E-print Network

    Verscharen, Daniel; Bourouaine, Sofiane; Hollweg, Joseph V

    2014-01-01

    Protons and alpha particles in the fast solar wind are only weakly collisional and exhibit a number of non-equilibrium features, including relative drifts between particle species. Two non-collisional mechanisms have been proposed for limiting differential flow between alpha particles and protons: plasma instabilities and the rotational force. Both mechanisms decelerate the alpha particles. In this paper, we derive an analytic expression for the rate $Q_{\\mathrm{flow}}$ at which energy is released by alpha-particle deceleration, accounting for azimuthal flow and conservation of total momentum. We find that $Q_{\\mathrm{flow}} > 0 $ at $r r_{\\mathrm{crit}}$. We compare the value of $Q_{\\mathrm{flow}}$ at $rUlysses spacecraft. We find that $Q_{\\mathrm{flow}}$ exceeds $Q_{\\alpha}$ at $r < 1\\,\\mathrm{AU}$, $Q_{...

  3. Search for {alpha}-states in {sup 13}C via elastic resonant scattering of {alpha} particles on {sup 9}Be

    SciTech Connect

    Lombardo, I.; Campajola, L.; Rosato, E.; Spadaccini, G.; Vigilante, M. [Dipartimento di Scienze Fisiche dell'Universita di Napoli Federico II INFN - Sezione di Napoli, Napoli (Italy)

    2013-07-18

    We will discuss new experimental data concerning the elastic resonant scattering of {alpha}-particles on {sup 9}Be nuclei at bombarding energies from 3.5 MeV up to 9.9 MeV. Several excitation functions have been obtained at different polar angles, mainly in the backward hemisphere in the centre of mass frame. Excitation functions show various anomalies that can be linked to the presence of various excited states in the {sup 13}C compound nucleus. In the literature, some of these states have been proposed to belong to rotational bands built on deformed a-cluster excited state. Unfortunately, up to date the spin-parity assignment of many of these states is doubtful. The set of excitation functions we obtained from the present experiment can contribute to improve spectroscopy of highling excited states of {sup 13}C.

  4. Study of excitation functions of alpha-particle induced nuclear reactions on holmium for 167Tm production.

    PubMed

    Tárkányi, F; Hermanne, A; Király, B; Takács, S; Ignatyuk, A V

    2010-03-01

    (167)Tm is a candidate radioisotope for both nuclear medicine diagnostics and therapy due to its emitted Auger-electrons, low energy X- and gamma-rays. In the frame of a systematic study of excitation functions for production of medically relevant radioisotopes by charged particle induced reactions on rare earths, the (165)Ho(alpha,2n)(167)Tm reaction and the (165)Ho(alpha,n)(168)Tm, (165)Ho(alpha,3n)(166)Tm, (165)Ho(alpha,4n)(165)Tm side reactions were measured up to 40 MeV by the stacked foil irradiation technique and gamma-ray spectroscopy. The measured results were compared to the ALICE-IPPE and EMPIRE-II theoretical curves. Thick target yields, impurity levels and specific activities were deduced and compared with the same parameters for other charged particle production routes of (167)Tm. PMID:20022515

  5. Alpha-particle-driven instability of alfven waves in a tandem mirror. Final summary report, 21 February-20 May 1985

    SciTech Connect

    Ho, S.K.

    1985-08-20

    Alpha particles born at D-T fusion are mirror confined in the tandem mirror due to their relatively high energy. Therefore, they have a loss-cone type distribution in the velocity space. This anisotropy is susceptible to microinstability. The objective of this work is to study the possible instability that can be driven by the alpha loss-cone. The low frequency (at the order of the ion cyclotron frequency) wave spectrum is studied to seek the waves that can be destabilized by the alphas. The radial mode structure is found for the growth rate calculation. The alpha particle distribution with a loss-cone is obtained from a Legendre function expansion and a diffusion front method. The growth rate of the instability is formulated from linear stability theory and computed numerically. A marginal stability boundary in the ion density and temperature parameters is calculated.

  6. Alpha particles induce apoptosis through the sphingomyelin pathway.

    PubMed

    Seideman, Jonathan H; Stancevic, Branka; Rotolo, Jimmy A; McDevitt, Michael R; Howell, Roger W; Kolesnick, Richard N; Scheinberg, David A

    2011-10-01

    The sphingomyelin pathway involves the enzymatic cleavage of sphingomyelin to produce ceramide, a second messenger that serves as a key mediator in the rapid apoptotic response to various cell stressors. Low-linear energy transfer (LET) ? radiation can initiate this pathway, independent of DNA damage, via the cell membrane. Whether short-ranged, high-LET ? particles, which are of interest as potent environmental carcinogens, radiotherapies and potential components of dirty bombs, can act through this mechanism to signal apoptosis is unknown. Here we show that irradiation of Jurkat cells with ? particles emitted by the ˛˛?Ac-DOTA-anti-CD3 IgG antibody construct results in dose-dependent apoptosis. This apoptosis was significantly reduced by pretreating cells with cholesterol-depleting nystatin, a reagent known to inhibit ceramide signaling by interfering with membrane raft coalescence and ceramide-rich platform generation. The effects of nystatin on ?-particle-induced apoptosis were related to disruption of the ceramide pathway and not to microdosimetry alterations, because similar results were obtained after external irradiation of the cells with a broad beam of collimated ? particles using a planar ˛?šAm source. External irradiation allowed for more precise control of the dosimetry and geometry of the irradiation, independent of antibody binding or cell internalization kinetics. Mechanistically consistent with these findings, Jurkat cells rapidly increased membrane concentrations of ceramide after external irradiation with an average of five ?-particle traversals per cell. These data indicate that ? particles can activate the sphingomyelin pathway to induce apoptosis. PMID:21631289

  7. Enhanced homologous recombination is induced by alpha-particle radiation in somatic cells of Arabidopsis thaliana

    NASA Astrophysics Data System (ADS)

    Bian, Po; Liu, Ping; Wu, Yuejin

    Almost 9 percent of cosmic rays which strike the earth's atmosphere are alpha particles. As one of the ionizing radiations (IR), its biological effects have been widely studied. However, the plant genomic instability induced by alpha-particle radiation was not largely known. In this research, the Arabidopsis thaliana transgenic for GUS recombination substrate was used to evaluate the genomic instability induced by alpha-particle radiation (3.3MeV). The pronounced effects of systemic exposure to alpha-particle radiation on the somatic homologous recombination frequency (HRF) were found at different doses. The 10Gy dose of radiation induced the maximal HRF which was 1.9-fold higher than the control. The local radiation of alpha-particle (10Gy) on root also resulted in a 2.5-fold increase of somatic HRF in non-radiated aerial plant, indicating that the signal(s) of genomic instability was transferred to non-radiated parts and initiated their genomic instability. Concurrent treatment of seedlings of Arabidopsis thaliana with alpha-particle and DMSO(ROS scavenger) both in systemic and local radiation signifi- cantly suppressed the somatic HR, indicating that the free radicals produced by alpha-particle radiation took part in the production of signal of genomic instability rather than the signal transfer. Key words: alpha-particle radiation, somatic homologous recombination, genomic instability

  8. WIND Measurements of Proton and Alpha Particle Flow and Number Density J. T. Steinberg

    E-print Network

    Richardson, John

    for investigating the interplanetary edium. The solar wind experiment (SWE) on WIND e e includes 2 Faraday cup-alpha particle differential flow can s a be determined. We present early SWE Faraday cup result nd compare proton detectors for measuring th nergy/charge spectrum of solar wind protons and alpha f t particles. The Faraday

  9. Ion Densities and Particle Charges for Alpha Ionization in an Aerosol Atmosphere: Columnar Recombination Corrections

    Microsoft Academic Search

    Y. S. Mayya; W. Holländer

    1995-01-01

    Ionization by alpha sources in an environment containing small aerosol particles is of interest in aerosol neutralizes, particle chargers and atmospheric electricity. It is known that the conventional ion-balance equation is inadequate in describing the bulk ion densities for alpha sources in view of the columnar recombination process. An earlier self-consistent formulation to include this effect is extended to the

  10. Feasibility study on the use of polyallyldiglycol-carbonate cell dishes in TUNEL assay for alpha particle radiobiological experiments

    NASA Astrophysics Data System (ADS)

    Chan, K. F.; Yum, E. H. W.; Wan, C. K.; Fong, W. F.; Yu, K. N.

    2007-08-01

    In the present work, we have studied the feasibility of a method based on polyallyldiglycol-carbonate (PADC) films to investigate the effects of alpha particles on HeLa cervix cancer cells. Thin PADC films with thickness of about 20 ?m were prepared from commercially available CR-39 films by chemical etching to fabricate custom-made petri dishes for cell culture, which could accurately record alpha particle hit positions. A special method involving "base tracks" for aligning the images of cell nuclei and alpha particle hits has been proposed, so that alpha particle transversals of cell nuclei can be visually counted. Radiobiological experiments were carried out to induce DNA damages, with the TdT-mediated d UTP Nick- End Labeling (TUNEL) fluorescence method employed to detect DNA strand breaks. The staining results were investigated by flow cytometer. The preliminary results showed that more strand breaks occurred in cells hit by alpha particles with lower energies. Moreover, large TUNEL positive signals were obtained even with small percentages of cells irradiated and TUNEL signals were also obtained from non-targeted cells. These provided evidence for the bystander effect.

  11. High-resolution alpha-particle spectroscopy with an hybrid SiC\\/GaN detector\\/front-end detection system

    Microsoft Academic Search

    A. Pullia; G. Bertuccio; D. Maiocchi; S. Caccia; F. Zocca

    2007-01-01

    An alpha-particle spectrometer has been assembled, consisting of an epitaxial 50 mum thick 4H silicon carbide detector connected to a gallium nitride HEMT used as input transistor of the front-end electronics. The depleted layer of the SiC diode detector was sufficient to stop all alpha particles of the used emitter in the 4.8-MeV to 5.8-MeV energy range. An excellent energy

  12. Quantum 1/f noise in nondegenerate semiconductors and emission statistics of alpha particles

    SciTech Connect

    Kousik, G.S.

    1985-01-01

    Charged particle scattering is accompanied by the emission of soft photons. Handel's theory of 1/f noise, based on the infrared divergent coupling of the system to the electromagnetic field or other elementary excitations, states that the current associated with a beam of scattered particles will exhibit 1/f noise. The fraction of the particles scattered with an energy loss epsilon to soft photon emission is proportional to 1/epsilon and herein lies the origin of the quantum theory of 1/f noise. The 1/f noise caused by mobility fluctuations in semiconductors is related to the scattering cross section fluctuation given by Handel's theory, through the relaxation time. Results are presented of the detailed calculation of mobility fluctuation 1/f noise and Hooge parameter in nondegenerate semiconductors. Numerical results are given for silicon and gallium arsenide. Data obtained from extensive measurements on counting techniques for alpha-particle radioactive decay from a source containing /sub 94/Pu/sup 239/, /sub 95/Am/sup 241/ and /sub 96/Cm/sup 244/ are presented. These data show that the statistics are non-Poissonian for large counting times (of the order of 1000 minutes) contrary to the popular belief that alpha decay is an example of Poissonian statistics.

  13. Effects of alpha particles on the angular momentum loss from the Sun

    E-print Network

    Bo Li; Xing Li

    2006-06-07

    The classic Weber-Davis model of the solar wind is reconsidered by incorporating alpha particles and by allowing the solar wind to flow out of the equatorial plane in an axisymmetrical configuration. In the ion momentum equations of the solar wind, the ion gyro-frequency is many orders of magnitude higher than any other frequency. This requires that the difference between proton and alpha velocity vectors be aligned with the background magnetic field. With the aid of this alignment condition, the governing equations of the multi-fluid solar wind are derived from the standard transport equations. The governing equations are numerically solved along a prescribed meridional magnetic field line located at colatitude $70^\\circ$ at 1AU and a steady state fast solar wind solution is found. A general analysis concludes, in agreement with the Weber-Davis model, that the magnetic field helps the coronal plasma to achieve an effective corotation out to the Alfv\\'enic radius, where the poloidal Alfv\\'enic Mach number $M_T$ equals unity ($M_T$ is defined by equation (\\ref{eq:mach})). The model computations show that, magnetic stresses predominate the angular momentum loss of the Sun. For the fast wind considered, the proton contribution to the angular momentum loss, which can be larger than the magnetic one, is almost completely canceled by the alpha particles that develop an azimuthal speed in the direction opposite to the solar rotation. The Poynting flux associated with the azimuthal components is negligible in the energy budget. However, the solar rotation can play some role in reducing the relative speed between alpha particles and protons for low latitude fast solar wind streams in interplanetary space.

  14. Absolute number of photons produced by alpha-particles in liquid and gaseous xenon

    NASA Astrophysics Data System (ADS)

    Miyajima, Mitsuhiro; Sasaki, Shinichi; Shibamura, Eido

    1992-02-01

    The Ws which is defined as an average energy expended per scintillation photon, was found to be 16.3 ą 0.3 eV for alpha-particles in liquid xenon, and 49.6 ą 1.1 eV in gaseous xenon, respectively. These results followed from the number of photoelectrons measured with a VUV sensitive photomultiplier tube, which was used as a photodiode. The number of photoelectrons from the photomultiplier photocathode was measured absolutely with a well calibrated charge sensitive amplifier system as a function of distance between the alpha-source and the photomultiplier photocathode. The detection geometries included both reflective and nonreflective walls. The data were well fitted to corresponding curves obtained with a Monte Carlo simulation, and yielded the total number of scintillation photons.

  15. A Metastable Alpha-Particle Irradiation Induced Defect in n-GaAs

    NASA Astrophysics Data System (ADS)

    Auret, F.; Erasmus, Rudolph; Goodman, Stewart

    1994-04-01

    We report the introduction and characterization of a metastable alpha-particle irradiation induced defect, E?8, in n-GaAs by deep level transient spectroscopy (DLTS) using Schottky barrier diodes. The E?8 defect, with an energy level 0.18 eV below the conduction band, as determined by low-field DLTS measurements, could be reversibly transformed (removed and re-introduced) by employing zero and reverse bias anneals, respectively, in the 100 140 K temperature range. The transformation kinetics of E?8 displayed first order behaviour and was found to be charge state dependant.

  16. Angular distribution of {alpha} particles from oriented {sup 253,254}Es and {sup 255}Fm nuclei

    SciTech Connect

    Severijns, N.; Golovko, V.V.; Kraev, I.S.; Phalet, T. [Instituut voor Kern- en Stralingsfysica, K.U. Leuven, B-3001 Leuven (Belgium); Belyaev, A.A.; Lukhanin, A.A.; Noga, V.I. [Kharkov Institute of Physics and Technology, 61108 Kharkov (Ukraine); Erzinkyan, A.L.; Parfenova, V.P. [Institute of Nuclear Physics, Moscow State University, 119992 Moscow (Russian Federation); Eversheim, P.-D.; Herzog, P.; Tramm, C. [Helmholtz Institute fuer Strahlen- und Kernphysik, Universitaet Bonn, D-53115 Bonn (Germany); Filimonov, V.T.; Toporov, Yu.G.; Zotov, E. [Research Institute for Atomic Reactors, 433510 Dimitrovgrad-10 (Russian Federation); Gurevich, G.M.; Rusakov, A.V. [Institute for Nuclear Research, Russian Academy of Sciences, 119312, Moscow (Russian Federation); Vyachin, V.N. [RFNC All-Russian Scientific Research Institute of Experimental Physics, 607190 Sarov (Russian Federation); Zakoucky, D. [Nuclear Physics Institute, Academy of Sciences of Czech Republic, CZ-25068 Rez (Czech Republic)

    2005-04-01

    The anisotropy in the angular distribution of {alpha} particles from oriented {sup 253,254}Es and {sup 255}Fm nuclei, which are among the strongest deformed {alpha} emitters, was measured. Large {alpha} anisotropies have been observed for all three nuclei. The results are compared with calculations based on {alpha}-particle tunneling through a deformed Coulomb barrier.

  17. Alpha Particles Induce Apoptosis through the Sphingomyelin Pathway

    PubMed Central

    Seideman, Jonathan H.; Stancevic, Branka; Rotolo, Jimmy A.; McDevitt, Michael R.; Howell, Roger W.; Kolesnick, Richard N.; Scheinberg, David A.

    2011-01-01

    The sphingomyelin pathway involves the enzymatic cleavage of sphingomyelin to produce ceramide, a second messenger that serves as a key mediator in the rapid apoptotic response to various cell stressors. Low-linear energy transfer (LET) ? radiation can initiate this pathway, independent of DNA damage, via the cell membrane. Whether short-ranged, high-LET a particles, which are of interest as potent environmental carcinogens, radiotherapies and potential components of dirty bombs, can act through this mechanism to signal apoptosis is unknown. Here we show that irradiation of Jurkat cells with a particles emitted by the 225Ac-DOTA-anti-CD3 IgG antibody construct results in dose-dependent apoptosis. This apoptosis was significantly reduced by pretreating cells with cholesterol-depleting nystatin, a reagent known to inhibit ceramide signaling by interfering with membrane raft coalescence and ceramide-rich platform generation. The effects of nystatin on ?-particle-induced apoptosis were related to disruption of the ceramide pathway and not to microdosimetry alterations, because similar results were obtained after external irradiation of the cells with a broad beam of collimated a particles using a planar 241Am source. External irradiation allowed for more precise control of the dosimetry and geometry of the irradiation, independent of antibody binding or cell internalization kinetics. Mechanistically consistent with these findings, Jurkat cells rapidly increased membrane concentrations of ceramide after external irradiation with an average of five ?-particle traversals per cell. These data indicate that a particles can activate the sphingomyelin pathway to induce apoptosis. PMID:21631289

  18. PPPL-3253, Preprint: June 1997, UC-420, 426, 427 Alpha Particle Loss in TFTR Deuterium-Tritium Plasmas

    E-print Network

    PPPL-3253, Preprint: June 1997, UC-420, 426, 427 Alpha Particle Loss in TFTR Deuterium-Tritium ions. This paper presents calculations of guiding-center code alpha particle orbit loss from deuterium-tritium

  19. Cancer Stem Cell Targeting Using the Alpha-Particle Emitter, 213Bi: Mathematical Modeling and Feasibility Analysis

    PubMed Central

    Sgouros, George; Song, Hong

    2010-01-01

    There is increasing recognition that treatment failure in cancer may be associated with the failure to sterilize a small subpopulation of tumor cells that have been characterized as tumor stem cells. Defined as cells that are able to self-renew and also to replenish a phenotypically diverse tumor-cell population, such cells are also considered resistant to chemotherapy. These characteristics are optimal for targeting by using alpha-particle-emitting radionuclides. Because of their high-energy deposition density per track, alpha-particles are capable of targeting single cells or small clusters of cells with minimal normal organ toxicity. The DNA damage induced by alpha-particles is largely irreparable and, therefore, alpha-particle-induced damage is minimally susceptible to resistance mechanisms. In this work, theoretical modeling was performed to examine the potential of alpha-emitter targeting of such small clusters of cancer stem cells. Critical parameters influencing efficacy and toxicity were identified and their relationship elucidated. The results identify specific activity, antigen site density, and number of target cells as critical parameters for effective cell killing and demonstrate substantial efficacy gains by targeting a smaller number of stem cells, as opposed to the entire tumor-cell population. PMID:18298331

  20. High precision {sup 89}Y({alpha},{alpha}){sup 89}Y scattering at low energies

    SciTech Connect

    Kiss, G. G.; Fueloep, Zs.; Gyuerky, Gy.; Elekes, Z.; Somorjai, E. [Institute of Nuclear Research (ATOMKI), H-4001 Debrecen (Hungary); Mohr, P. [Diakonie-Klinikum, D-74523 Schwaebisch Hall (Germany); Galaviz, D. [Instituto de Estructura de la Materia, CSIC, E-28006 Madrid (Spain); Kretschmer, A.; Sonnabend, K. [Institut fuer Kernphysik, Technische Universitaet Darmstadt, D-64289 Darmstadt (Germany); Zilges, A. [Institut fuer Kernphysik, Universitaet zu Koeln, D-50937 Koeln (Germany); Avrigeanu, M. [Horia Hulubei National Institute for Physics and Nuclear Engineering, RO-76900 Bucharest (Romania)

    2009-10-15

    Elastic scattering cross sections of the {sup 89}Y({alpha},{alpha}){sup 89}Y reaction have been measured at energies E{sub c.m.}=15.51 and 18.63 MeV. The high-precision data for the semimagic N=50 nucleus {sup 89}Y are used to derive a local potential and to evaluate the predictions of global and regional {alpha}-nucleus potentials. The variation of the elastic {alpha}-scattering cross sections along the N=50 isotonic chain is investigated by a study of the ratios of angular distributions for {sup 89}Y({alpha},{alpha}){sup 89}Y and {sup 92}Mo({alpha},{alpha}){sup 92}Mo at E{sub c.m.}{approx_equal}15.51 and 18.63 MeV. This ratio is a very sensitive probe at energies close to the Coulomb barrier, where scattering data alone is usually not enough to characterize the different potentials. Furthermore, {alpha}-cluster states in {sup 93}Nb={sup 89}Y x {alpha} are investigated.

  1. Energy dependence of event shapes and of $\\\\alpha_s$ at LEP 2

    Microsoft Academic Search

    P. Abreu; W Adam; T Adye; P Adzic; Z Albrecht; T Alderweireld; G D Alekseev; R Alemany; T Allmendinger; P P Allport; S Almehed; Ugo Amaldi; N Amapane; S Amato; E G Anassontzis; P Andersson; A Andreazza; S Andringa; P Antilogus; W D Apel; Y Arnoud; B Ĺsman; J E Augustin; A Augustinus; Paul Baillon; P Bambade; F Barăo; Guido Barbiellini; R Barbier; Dimitri Yuri Bardin; G Barker; A Baroncelli; Marco Battaglia; M Baubillier; K H Becks; M Begalli; A Behrmann; P Beilličre; Yu A Belokopytov; K S Belous; N C Benekos; Alberto C Benvenuti; C Bérat; M Berggren; D Bertini; D Bertrand; M Besançon; F Bianchi; M Bigi; S M Bilenky; M A Bizouard; D Bloch; H M Blom; M Bonesini; W Bonivento; M Boonekamp; P S L Booth; A W Borgland; G Borisov; C Bosio; O Botner; E Boudinov; B Bouquet; C Bourdarios; T J V Bowcock; I Boyko; I Bozovic; M Bozzo; P Branchini; T Brenke; R A Brenner; P Brückman; J M Brunet; L Bugge; T Buran; T Burgsmüller; Brigitte Buschbeck; P Buschmann; S Cabrera; M Caccia; M Calvi; T Camporesi; V Canale; F Carena; L Carroll; Carlo Caso; M V Castillo-Gimenez; A Cattai; F R Cavallo; V Chabaud; M M Chapkin; P Charpentier; L Chaussard; P Checchia; G A Chelkov; R Chierici; P V Chliapnikov; P Chochula; V Chorowicz; J Chudoba; K Cieslik; P Collins; R Contri; E Cortina; G Cosme; F Cossutti; J H Cowell; H B Crawley; D J Crennell; S Crépé; G Crosetti; J Cuevas-Maestro; S Czellar; Martyn Davenport; W Da Silva; A Deghorain; G Della Ricca; P A Delpierre; N Demaria; A De Angelis; Wim de Boer; C De Clercq; B De Lotto; A De Min; L S De Paula; H Dijkstra; Lucia Di Ciaccio; J Dolbeau; K Doroba; M Dracos; J Drees; M Dris; A Duperrin; J D Durand; G Eigen; T J C Ekelöf; Gösta Ekspong; M Ellert; M Elsing; J P Engel; B Erzen; M C Espirito-Santo; E Falk; G K Fanourakis; D Fassouliotis; J Fayot; Michael Feindt; A Fenyuk; P Ferrari; A Ferrer; E Ferrer-Ribas; F Ferro; S Fichet; A Firestone; U Flagmeyer; H Föth; E Fokitis; F Fontanelli; B J Franek; A G Frodesen; R Frühwirth; F Fulda-Quenzer; J A Fuster; A Galloni; D Gamba; S Gamblin; M Gandelman; C García; C Gaspar; M Gaspar; U Gasparini; P Gavillet; E N Gazis; D Gelé; N Ghodbane; I Gil; F Glege; R Gokieli; B Golob; G Gómez-Ceballos; P Gonçalves; I González-Caballero; Gian P Gopal; L Gorn; M Górski; Yu Guz; Valerio Gracco; J Grahl; E Graziani; C Green; H J Grimm; P Gris; G Grosdidier; K Grzelak; M Günther; J Guy; F Hahn; S Hahn; S Haider; A Hallgren; K Hamacher; J Hansen; F J Harris; V Hedberg; S Heising; J J Hernández; P Herquet; H Herr; T L Hessing; J M Heuser; E Higón; S O Holmgren; P J Holt; S Hoorelbeke; M A Houlden; Josef Hrubec; K Huet; G J Hughes; K Hultqvist; J N Jackson; R Jacobsson; P Jalocha; R Janik; C Jarlskog; G Jarlskog; P Jarry; B Jean-Marie; E K Johansson; P E Jönsson; C Joram; P Juillot; F Kapusta; K Karafasoulis; S Katsanevas; E C Katsoufis; R Keränen; Borut P Kersevan; B A Khomenko; N N Khovanskii; A P Kiiskinen; B J King; A Kinvig; N J Kjaer; O Klapp; H Klein; P M Kluit; P Kokkinias; M Koratzinos; V Kostyukhin; C Kourkoumelis; O Kuznetsov; Manfred Krammer; E Kriznic; J Krstic; Z Krumshtein; P Kubinec; J Kurowska; K L Kurvinen; J Lamsa; P Langefeld; V Lapin; J P Laugier; R Lauhakangas; Gerhard Leder; F Ledroit; V Lefébure; L Leinonen; A Leisos; R Leitner; J Lemonne; Georg Lenzen; V Lepeltier; T Lesiak; M Lethuillier; J Libby; D Liko; A Lipniacka; I Lippi; B Lörstad; J G Loken; J H Lopes; J M López; R López-Fernandez; D Loukas; P Lutz; L Lyons; J N MacNaughton; J R Mahon; A Maio; A Malek; T G M Malmgren; S Maltezos; V Malychev; F Mandl; J Marco; R P Marco; B Maréchal; M Margoni; J C Marin; C Mariotti; A Markou; C Martínez-Rivero; F Martínez-Vidal; S Martí i García; N Mastroyiannopoulos; F Matorras; C Matteuzzi; Giorgio Matthiae; J Masik; F Mazzucato; M Mazzucato; M L McCubbin; R McKay; R McNulty; G McPherson; C Meroni; W T Meyer; E Migliore; L Mirabito; Winfried A Mitaroff; U Mjörnmark; T Moa; M Moch; R Mřller; K Mönig; M R Monge; X Moreau; P Morettini; G A Morton; U Müller; K Münich; M Mulders; C Mulet-Marquis; R Muresan; W J Murray; B Muryn; Gerald Myatt; T Myklebust; F Naraghi; M Nassiakou; Francesco Luigi Navarria; S Navas; K Nawrocki; P Negri; S Némécek; N Neufeld; N Neumeister; R Nicolaidou; B S Nielsen; M Nikolenko; V P Nomokonov; Ainsley Normand; A Nygren; V F Obraztsov; A G Olshevskii; A Onofre; Risto Orava; G Orazi; K Österberg; A Ouraou; M Paganoni; S Paiano; R Pain; R Paiva; J Palacios; H Palka; T D Papadopoulou; K Papageorgiou; L Pape; C Parkes; F Parodi; U Parzefall; A Passeri; O Passon; M Pegoraro; L Peralta; Manfred Pernicka; A Perrotta; C Petridou; A Petrolini; H T Phillips; F Pierre; M Pimenta; E Piotto; T Podobnik; M E Pol; G Polok; P Poropat; V Pozdnyakov; P Privitera; N Pukhaeva; Antonio Pullia; D Radojicic; S Ragazzi; H Rahmani; P N Ratoff; A L Read; P Rebecchi; N G Redaelli; Meinhard Regler; D Reid

    1999-01-01

    Infrared and collinear safe event shape distributions and their mean values are determined using the data taken at ve di erent centre of mass energies above $M_Z$ with the DELPHI detector at LEP. From the event shapes, the strong coupling $\\\\alpha_s$ is extracted in $O(\\\\alpha^2_s)$, NLLA and a combined scheme using hadronisation corrections evaluated with fragmentation model generators as well

  2. Results of the Alpha-Particle-X-Ray Spectrometer on Board of the Mars Exploration Rovers

    NASA Technical Reports Server (NTRS)

    Geller, R.; Zipfel, J.; Brueckner, J.; Dreibus, G.; Lugmair, G.; Rieder, R.; Waenke, H.; Klingelhoefer, G.; Clark, B. C.; Ming, D. W.

    2005-01-01

    The Mars Exploration Rovers Spirit and Opportunity landed at Gusev crater and Meridiani Planum. The Alpha Particle X-ray Spectrometer (APXS) is part of the instrument suite on both rovers. It is equipped with six 244Cm sources which provide x-ray excitation with alpha-particles (PIXE) and x-ray radiation (XRF). This combination allows x-ray spectroscopy of elements from Na to Br in the energy range of 0.9 to 16 keV. X-ray detectors with a high energy resolution of 160 eV at Fe K allow us to separate even closely spaced energy peaks, such as Na, Mg, Al and Si. The APXS is attached to the rover s arm and provides in-situ measurements of the chemical composition of soils, surfaces of rocks and outcrops and their abraded surfaces. This abstract gives an overview of APXS results obtained during the first year of operation on both landing sites.

  3. Feasibility study on the use of polyallyldiglycol-carbonate cell dishes in TUNEL assay for alpha particle radiobiological experiments

    E-print Network

    Yu, K.N.

    on polyallyldiglycol-carbonate (PADC) films to investigate the effects of alpha particles on HeLa cervix cancer cells to investigate the effects of alpha particles on HeLa cervix cancer cells. To directly provide evidence alpha particle hit positions. A special method involving ``base tracks'' for aligning the images of cell

  4. Dehydriding process of alpha-AlH{sub 3} observed by transmission electron microscopy and electron energy-loss spectroscopy

    SciTech Connect

    Muto, S.; Tatsumi, K. [Department of Materials, Physics and Energy Engineering, Graduate School of Engineering, Nagoya University, Nagoya 464-8603 (Japan); Ikeda, K.; Orimo, S. [Institute for Materials Research, Tohoku University, Sendai 980-8577 (Japan)

    2009-06-15

    The dehydriding reaction of alpha-AlH{sub 3} induced by high-energy electron irradiation was observed in situ by transmission electron microscopy and associated electron energy-loss spectroscopy (EELS). An alpha-AlH{sub 3} crystal decomposed into fine aluminum particles while retaining its initial external shape because of a thin rigid surface layer that covered the entire particle. EELS revealed that the thin surface layer was amorphous aluminum oxide, which stabilizes alpha-AlH{sub 3} particles at ambient temperature.

  5. WIND measurements of proton and alpha particle flow and number density

    NASA Technical Reports Server (NTRS)

    Steinberg, J. T.; Lazarus, A. J.; Ogilvie, J. T.; Lepping, R.; Byrnes, J.; Chornay, D.; Keller, J.; Torbert, R. B.; Bodet, D.; Needell, G. J.

    1995-01-01

    We propose to review measurements of the solar wind proton and alpha particle flow velocities and densities made since launch with the WIND SWE instrument. The SWE Faraday cup ion sensors are designed to be able to determine accurately flow vector directions, and thus can be used to detect proton-alpha particle differential flow. Instances of differential flow, and the solar wind features with which they are associated will be discussed. Additionally, the variability of the percentage of alpha particles as a fraction of the total solar wind ion density will be presented.

  6. MIRD Pamphlet No. 22 (Unabridged): Radiobiology and Dosimetry of alpha-Particle Emitters for Targeted Radionuclide Therapy

    SciTech Connect

    Sgouros, George; Roeske, John C.; McDevitt, Michael S.; Palm, Stig; Allen, Barry J.; Fisher, Darrell R.; Brill, Bertrand A.; Song, Hong; Howell, R. W.; Akabani, Gamal

    2010-02-28

    The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides, in radionuclide conjugation chemistry, and in the increased availability of alpha-emitters appropriate for clinical use have recently led to patient trials of alpha-particle-emitter labeled radiopharmaceuticals. Although alpha-emitters have been studied for many decades, their current use in humans for targeted therapy is an important milestone. The objective of this work is to review those aspects of the field that are pertinent to targeted alpha-particle-emitter therapy and to provide guidance and recommendations for human alpha-particle-emitter dosimetry.

  7. Alpha beam monitoring via natCu + alpha processes in the energy range from 40 to 60 MeV

    NASA Astrophysics Data System (ADS)

    Szelecsényi, Ferenc; Suzuki, Kazutoshi; Kovács, Zoltán; Takei, Makoto; Okada, Kazuhiro

    2001-12-01

    Excitation functions were measured using the stacked-foil method for alpha particle-induced nuclear reactions on natural copper leading to the formation of 61Cu, 66Ga and 67Ga in the energy range from 16 to 60 MeV. Extending the recommended database of the natCu( ?, x) 66Ga and natCu( ?, x) 67Ga processes with our new values, now the above processes can be used for alpha beam energy and intensity monitoring up to 60 MeV. On the basis of the present study it was found that the natCu( ?, x) 61Cu process is also a useful candidate for monitor purposes in the 40-60 MeV energy region.

  8. Calculation procedure of potential alpha energy concentration with continuous air sampling.

    PubMed

    Tokonami, S; Ichiji, T; Iimoto, T; Kurosawa, R

    1996-12-01

    A continuous potential alpha energy concentration monitor was developed to estimate the lung dose for inhalation of radon progeny. A silicon semiconductor detector was used as a detector. The build-up method was used and alpha particles emitted from 218Po, 214Po, 212Bi, and 212Po were detected. As 218Po and 212Bi have alpha particles of nearly the same energy, three detecting channels were set up. Counts corresponding to each nuclide were sent to a printer every 30 min. For the purpose of determining the potential alpha energy concentration of radon progeny continuously, a proper calculation procedure was investigated in detail. With this method, 218Po concentration and potential alpha energy concentration of radon progeny could be continuously obtained. The potential alpha energy concentration based on this procedure agreed well with that calculated from individual radon progeny concentration. When the measurement was done at 30-min intervals, the minimum detectable concentrations of 218Po concentration and equilibrium equivalent radon concentration were 0.3 Bq m(-3) and 0.15 Bq m(-3), respectively. The monitor can be used not only to estimate the lung dose but also to analyze environmental behavior of radon progeny. PMID:8919077

  9. Alpha particle driven current and torque in ITER baseline scenarios with 3D perturbations

    NASA Astrophysics Data System (ADS)

    Snicker, A.; Asunta, O.; Ylitie, H.; Kurki-Suonio, T.; Schneider, M.; Pinches, S. D.

    2015-06-01

    In this paper three-dimensional (3D) kinetic Monte Carlo orbit-following simulations are carried out with the ASCOT code to estimate the alpha particle driven current and torque profiles in ITER baseline scenarios. Several different 3D magnetic field configurations, including TF ripple, ferritic inserts, test blanket modules and edge localized mode coil perturbations, are used in these simulations. The alpha particle current is found to be less than one percent for all configurations and scenarios. In axisymmetric magnetic field configurations, the collisional and j × B torque components cancel each other, whilst in non-axisymmetric cases, the total torque is nonzero. The total alpha driven torque is found to oppose that generated by the neutral beam injection particles and to be an order of magnitude smaller. Consequently, alpha particles will not significantly contribute to the plasma current nor act as a source of plasma rotation in the ITER baseline scenarios considered.

  10. Influence of rotation-induced nuclear deformation on. alpha. -particle evaporation spectra

    SciTech Connect

    Huizenga, J.R.; Behkami, A.N.; Govil, I.M.; Schroder, W.U.; Toke, J. (Department of Chemistry and Nuclear Structure Research Laboratory, University of Rochester, Rochester, New York 14627 (US))

    1989-08-01

    The shapes of {alpha}-particle spectra from hot, high-spin compound nuclei produced in energetic heavy-ion fusion reactions are analyzed within the framework of a statistical model. Contrary to claims made in the literature, good agreement is obtained between calculated and experimental spectra when the evaporation barrier of each nuclide in the complex cascade is assumed equal to its respective absorption channel barrier. The dependence of the shape of {alpha}-particle spectra on nuclear deformation is discussed both in terms of the transmission coefficients and the spin-dependent level density of deformed nuclei. For deformations of the magnitude given by the rotating liquid drop model, {alpha}-particle spectra and effective barriers are insensitive to whether deformed or spherical nucleus transmission coefficients are used. It is important, however, to include the deformation dependence in the nuclear level density. Model calculations indicate that the shape of {alpha}-particle spectra may be quite insensitive to large deformations.

  11. Direct and indirect effects of alpha-particle irradiations of human prostate tumor cells

    E-print Network

    Wang, Rong, Ph. D. Massachusetts Institute of Technology

    2005-01-01

    The objective of this project is to establish a model system to study the direct effect, the bystander effect and the combinational effect of alpha-particle irradiations of human prostate tumor cells, toward the goal of ...

  12. Reexamination of the {alpha}-{alpha}''fishbone'' potential

    SciTech Connect

    Day, J. P.; McEwen, J. E.; Elhanafy, M.; Smith, E.; Woodhouse, R.; Papp, Z. [Department of Physics and Astronomy, California State University Long Beach, Long Beach, California (United States)

    2011-09-15

    The fishbone potential of composite particles simulates the Pauli effect by nonlocal terms. We determine the {alpha}-{alpha} fishbone potential by simultaneously fitting to two-{alpha} resonance energies, experimental phase shifts, and three-{alpha} binding energies. We found that, essentially, a simple Gaussian can provide a good description of two-{alpha} and three-{alpha} experimental data without invoking three-body potentials.

  13. LIMITS ON ALPHA PARTICLE TEMPERATURE ANISOTROPY AND DIFFERENTIAL FLOW FROM KINETIC INSTABILITIES: SOLAR WIND OBSERVATIONS

    SciTech Connect

    Bourouaine, Sofiane; Verscharen, Daniel; Chandran, Benjamin D. G. [Space Science Center, University of New Hampshire, Durham, NH 03824 (United States)] [Space Science Center, University of New Hampshire, Durham, NH 03824 (United States); Maruca, Bennett A. [Space Science Laboratory, University of California, Berkeley, CA 94720 (United States)] [Space Science Laboratory, University of California, Berkeley, CA 94720 (United States); Kasper, Justin C., E-mail: s.bourouaine@unh.edu [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States)

    2013-11-01

    Previous studies have shown that the observed temperature anisotropies of protons and alpha particles in the solar wind are constrained by theoretical thresholds for pressure and anisotropy driven instabilities such as the Alfvén/ion-cyclotron (A/IC) and fast-magnetosonic/whistler (FM/W) instabilities. In this Letter, we use a long period of in situ measurements provided by the Wind spacecraft's Faraday cups to investigate the combined constraint on the alpha proton differential flow velocity and the alpha particle temperature anisotropy due to A/IC and FM/W instabilities. We show that the majority of the data are constrained to lie within the region of parameter space in which A/IC and FM/W waves are either stable or have extremely low growth rates. In the minority of observed cases in which the growth rate of the A/IC (FM/W) instability is comparatively large, we find relatively higher values of T {sub ?}/T {sub p} (T {sub ??}/T {sub ?p}) when the alpha proton differential flow velocity is small, where T {sub ?} and T {sub p} (T {sub ??} and T {sub ?p}) are the perpendicular (parallel) temperatures of alpha particles and protons. We conjecture that this observed feature might arise from preferential alpha particle heating which can drive the alpha particles beyond the instability thresholds.

  14. Limits on Alpha Particle Temperature Anisotropy and Differential Flow from Kinetic Instabilities: Solar Wind Observations

    NASA Astrophysics Data System (ADS)

    Bourouaine, Sofiane; Verscharen, Daniel; Chandran, Benjamin D. G.; Maruca, Bennett A.; Kasper, Justin C.

    2013-11-01

    Previous studies have shown that the observed temperature anisotropies of protons and alpha particles in the solar wind are constrained by theoretical thresholds for pressure and anisotropy driven instabilities such as the Alfvén/ion-cyclotron (A/IC) and fast-magnetosonic/whistler (FM/W) instabilities. In this Letter, we use a long period of in situ measurements provided by the Wind spacecraft's Faraday cups to investigate the combined constraint on the alpha proton differential flow velocity and the alpha particle temperature anisotropy due to A/IC and FM/W instabilities. We show that the majority of the data are constrained to lie within the region of parameter space in which A/IC and FM/W waves are either stable or have extremely low growth rates. In the minority of observed cases in which the growth rate of the A/IC (FM/W) instability is comparatively large, we find relatively higher values of T ?/T p (T ??/T ?p ) when the alpha proton differential flow velocity is small, where T ? and T p (T ?? and T ?p ) are the perpendicular (parallel) temperatures of alpha particles and protons. We conjecture that this observed feature might arise from preferential alpha particle heating which can drive the alpha particles beyond the instability thresholds.

  15. Alpha-particle interactions with nuclei at 12A GeV/c

    SciTech Connect

    Claesson, G.; Garpman, S.; Lund, I.; Otterlund, I.; Stenlund, E.; Soederstroem, K.; Bhalla, K.B.; Bharti, A.; Kumar, V.; Lokanathan, S.

    1986-05-01

    Pseudorapidity-density distributions of shower particles from 12A-GeV/c ..cap alpha..-emulsion interactions are presented. As compared to extrapolations from p-nucleus data, the central ..cap alpha..+(Ag,Br) interactions exhibit an excess of particles in the middle pseudorapidity region. The correlation between and can be understood within a wounded-nucleon model.

  16. High-spin particle states in 153Sm studied with the (alpha, 3He) reaction

    Microsoft Academic Search

    J. R. Lien; G. Lřvhřiden; J. Rekstad; A. Henriques; C. Gaarde; J. S. Larsen; S. Y. van der Werf

    1984-01-01

    High-spin states have been located in 153Sm by means of the (alpha, 3He) reaction with 40 MeV alpha-particles. The scattered particles were momentum-analysed in a QMG\\/2 magnetic spectrometer and recorded in a position-sensitive detector. Several high-spin states were observed below 2 MeV of excitation. Strongly populated levels at 698, 1118 and 1708 keV can most likely be interpreted as 13\\/2+

  17. Evaluation of ZnO(Ga)Coatings as Alpha Particle Transducers Within a Neutron Generator

    Microsoft Academic Search

    J. T. Mihalczo; J. S. Neal; J. C. Cooper; D. S. Koltick

    2002-01-01

    We report investigations and preliminary results from efforts to develop a recoil alpha particle detector for use in a portable neutron generator. The associated particle sealed tube neutron generator (APSTNG) will be used as an interrogation source for the Nuclear Materials Identification System (NMIS). With the emission of 14.1 MeV neutrons produced by the D-T reaction, associated 3.5 MeV alpha

  18. On resonant excitations of high-n magnetohydrodynamic modes by energetic/alpha particles in tokamaks

    SciTech Connect

    Chen, Liu

    1989-03-01

    Analytical theories for the excitations in tokamaks of magnetohydrodynamic (MHD) modes with large toroidal mode numbers (n>>1) are presented. Specifically, only instability mechanisms due to resonances with energetic ions/alpha particles are considered. It is noted that, while trapped energetic particles contribute to the ideal region, circulating energetic particles contribute mainly to the singular layer dynamics. A unified dispersion relation manifesting both fishbone-like modes and beam transit-resonance modes is then driven. Finally, we also analyze the stability property of toroidicity-induced shear Alfven waves excited via transit resonances with alpha particles in ignited tokamaks. 11 refs.

  19. Cytotoxicity of alpha-particle-emitting astatine-211-labelled antibody in tumour spheroids: no effect of hyperthermia.

    PubMed Central

    Hauck, M. L.; Larsen, R. H.; Welsh, P. C.; Zalutsky, M. R.

    1998-01-01

    The high linear energy transfer, alpha-particle-emitting radionuclide astatine-211 (211At) is of interest for certain therapeutic applications; however, because of the 55- to 70-microm path length of its alpha-particles, achieving homogeneous tracer distribution is critical. Hyperthermia may enhance the therapeutic efficacy of alpha-particle endoradiotherapy if it can improve tracer distribution. In this study, we have investigated whether hyperthermia increased the cytotoxicity of an 211At-labelled monoclonal antibody (MAb) in tumour spheroids with a radius (approximately 100 microm) greater than the range of 211At alpha-particles. Hyperthermia for 1 h at 42 degrees C was used because this treatment itself resulted in no regrowth delay. Radiolabelled chimeric MAb 81C6 reactive with the extracellular matrix antigen tenascin was added to spheroids grown from the D-247 MG human glioma cell line at activity concentrations ranging from 0.125 to 250 kBq ml(-1). A significant regrowth delay was observed at 125 and 250 kBq ml(-1) in both hyperthermia-treated and untreated spheroids. For groups receiving hyperthermia, no increase in cytotoxicity was seen compared with normothermic controls at any activity concentration. These results and those from autoradiographs indicate that hyperthermia at 42 degrees C for 1 h had no significant effect on the uptake or distribution of this antitenascin MAb in D-247 MG spheroids. Images Figure 4 Figure 5 PMID:9514054

  20. Schottky barrier detectors on 4H-SiC n-type epitaxial layer for alpha particles

    NASA Astrophysics Data System (ADS)

    Chaudhuri, S. K.; Krishna, R. M.; Zavalla, K. J.; Mandal, K. C.

    2013-02-01

    Schottky barrier detectors have been fabricated on 50 ?m n-type 4H-SiC epitaxial layers grown on 360 ?m SiC substrates by depositing ?10 nm nickel contact. Current-voltage (I-V) and capacitance-voltage (C-V) measurements were carried out to investigate the Schottky barrier properties. The detectors were evaluated for alpha particle detection using a 241Am alpha source. An energy resolution of ?2.7% was obtained with a reverse bias of 100 V for 5.48 MeV alpha particles. The measured charge collection efficiency (CCE) was seen to vary as a function of bias voltage following a minority carrier diffusion model. Using this model, a diffusion length of?3.5 ?m for holes was numerically calculated from the CCE vs. bias voltage plot. Rise-time measurements of digitally recorded charge pulses for the 5.48 MeV alpha particles showed a presence of two sets of events having different rise-times at a higher bias of 200 V. A biparametric correlation scheme was successfully implemented for the first time to visualize the correlated pulse-height distribution of the events with different rise-times. Using the rise-time measurements and the biparametric plots, the observed variation of energy resolution with applied bias was explained.

  1. Bose-Einstein condensation of {alpha} particles and Airy structure in nuclear rainbow scattering

    SciTech Connect

    Ohkubo, S. [Department of Applied Science and Environment, Kochi Women's University, Kochi 780-8515 (Japan); Hirabayashi, Y. [Information Initiative Center, Hokkaido University, Sapporo 060-0810 (Japan)

    2004-10-01

    It is shown that the dilute density distribution of {alpha} particles in nuclei can be observed in the Airy structure in nuclear rainbow scattering. We have analyzed {alpha}+{sup 12}C rainbow scattering to the 0{sub 2}{sup +} (7.65 MeV) state of {sup 12}C in a coupled-channel method with the precise wave functions for {sup 12}C. It is found that the enhanced Airy oscillations in the experimental angular distributions for the 0{sub 2}{sup +} state is caused by the dilute density distribution of this state in agreement for the idea of Bose-Einstein condensation of the three alpha particles.

  2. Quantum 1/f noise in non-degerate semiconductors and emission statistics of alpha particles

    SciTech Connect

    Kousik, G.S.

    1985-01-01

    Charged particle scattering is accompanied by the emission of soft photons. Handel's theory of 1/f noise, based on the infrared divergent coupling of the system to the electromagnetic field or other elementary excitations, states that the current associated with a beam of scattered particles will exhibit 1/f noise. The fraction of the particles scattered with an energy loss epsilon to soft photon emission is proportional to 1/epsilon and herein lies the origin of the quantum theory of 1/f noise. The 1/f noise caused by mobility fluctuations in semiconductors is related to the scattering cross section fluctuation given by Handel's theory, through the relaxation time. Chapters Two through Five of this dissertation presents the results of the detailed calculation of mobility fluctuation 1/f noise and Hooge parameter in nondegenerate semiconductors. Numerical results are given for silicon and gallium arsenide. Data obtained from extensive measurements on counting techniques for alpha-particles radioactive decay from a source containing /sub 94/Pu/sup 239/, /sub 95/Am/sup 241/ and /sub 96/Cm/sup 244/ are presented in Chapters Six and Seven of this dissertation. These data show that the statistics are non-Poissonian for large counting times (of the order of 1000 minutes) contrary to the popular belief that alpha-decay is an example of Poissonian statistics. Measurements of the Allan variance indicated the presence of a slow Lorentzian flicker noise and 1/f noise and the magnitude of the noise for large counting times is considerably larger than that predicted by Poissonian statistics.

  3. A single particle energies

    SciTech Connect

    Bodmer, A.R. [Illinois Univ., Chicago, IL (United States). Dept. of Physics]|[Argonne National Lab., IL (United States); Usmani, Q.N.; Sami, M. [Jamia Millia Islamia, New Delhi (India). Dept. of Physics

    1993-09-01

    We consider the binding energies of {Lambda} hypernuclei (HN), in particular the single-particle (s.p.) energy data, which have been obtained for a wide range of HN with mass numbers A {le} 89 and for orbital angular momenta {ell}{sub {Lambda}} {le} 4. We briefly review some of the relevant properties of A hypernuclei. These are nuclei {sub {Lambda}}{sup A}Z with baryon number A in which a single {Lambda} hyperon (baryon number = 1) is bound to an ordinary nucleus {sup A}Z consisting of A - 1 nucleons = Z protons + N neutrons. The {Lambda} hyperon is neutral, has spin 1/2, strangeness S = {minus}1, isospin I = O and a mass M{sub {Lambda}} = 1116 MeV/c{sup 2}. Although the {Lambda} interacts with a nucleon, its interaction is only about half as strong as that between two nucleons, and thus very roughly V{sub {Lambda}N} {approx} 0.5 V{sub NN}. As a result, the two-body {Lambda}N system is unbound, and the lightest bound HN is the three-body hypertriton {sub {Lambda}}{sup 3}H in which the {Lambda} is bound to a deuteron with the {Lambda}-d separation energy being only {approx} 0.1 MeV corresponding to an exponential tail of radius {approx} 15 fm! In strong interactions the strangeness S is of course conserved, and the {Lambda} is distinct from the nucleons. In a HN strangeness changes only in the weak decays of the {Lambda} which can decay either via ``free`` pionic decay {Lambda} {yields} N + {pi} or via induced decay {Lambda} + N {yields} N + N which is only possible in the presence of nucleons. Because of the small energy release the pionic decay is strongly suppressed in all but the lightest HN and the induced decay dominates. However, the weak decay lifetime {approx} 10{sup {minus}10}s is in fact close to the lifetime of a free {Lambda}. Since this is much longer than the strong interaction time {approx} 10{sup {minus}22}s we can ignore the weak interactions when considering the binding of HN, just as for ordinary nuclei.

  4. High energy proton and alpha radiation effects on GaAs\\/AlGaAs quantum well infrared photodetectors

    Microsoft Academic Search

    S. M. Khanna; H. C. Liu; P. H. Wilson; L. Li; M. Buchanan

    1996-01-01

    Gallium arsenide quantum well infrared photodetectors (QWIPs) are ideally suited for infrared imagery due to their detection capability over a wide infrared wavelength region and the feasibility of fabrication of monolithic two-dimensional arrays of such detectors. This paper reports on the effects of high energy proton and alpha particle radiations on the performance of these devices. The particle energies ranged

  5. Scattering of 42 MeV alpha particles from copper-65

    NASA Technical Reports Server (NTRS)

    Stewart, W. M.; Seth, K. K.

    1973-01-01

    Beams of 42-MeV alpha particles were elastically and inelastically scattered from Cu-65 in an attempt to excite states which may be described in terms of an excited core model. Angular distributions were measured for 17 excited states. Seven of the excited states had angular distributions similar to a core quadrupole excitation and eight of the excited states had angular distributions similar to a core octupole excitation. The excited state at 2.858 MeV had an angular distribution which suggests that it may have results from the particle coupling to a two-phonon core state. An extended particle-core coupling calculation was performed and the predicted energy levels and reduced transition probabilities compared to the experimental data. The low lying levels are described quite well and the wavefunctions of these states explain the large spectroscopic factors measured in stripping reactions. For Cu-65 the coupling of the particle to the core is no larger weak as in the simpler model, and configuration mixing results.

  6. Simulation of {alpha}-particle redistribution due to sawteeth on TFTR

    SciTech Connect

    Yi Zhao; White, R.B.

    1996-12-31

    In recent Deuterium-Tritium experiments on the Tokamak Fusion Test Reactor (TFTR), both the Pellet Charge Exchange (PCX) and the alpha Charge Exchange Recombination Spectroscopy ({alpha}-CHERS) diagnostics indicate that sawtooth oscillations can cause significant broadening of the fusion alpha radial density profile. The authors investigate this sawtooth mixing phenomenon by applying a Hamiltonian guiding center approach. A model of time evolution of the Kadomtsev-type sawtooth is constructed. The presence of more than one mode in the nonlinear stage of the sawtooth crash is necessary to cause significant broadening of the alpha density profile. Use of numerical equilibria allows us to perform detailed comparisons with TFTR experimental data. The results are in reasonable agreement with {alpha}-CHERS and show a broadening of alpha particles similar to that seen in PCX measurements.

  7. IV. ALPHA-PARTICLE PHYSICS IN BPX D. J. SIGMAR (MIT)

    E-print Network

    al- FUSION TECHNOLOGY VOL. 21 MAY 1992 pha power balance that the coupling parameter qa E [Pa distribution (fa) averaged al- pha pressure including the effect of ur, on the ki- netic equation for fa. (For. Quantitative measurements of 7"" due to al- pha particles require Q 2 2. 1113 #12;Sigmar ALPHA-PARTICLE PHYSICS

  8. Study on the Sensitivity of Solid State Nuclear Track Detector (SSNTD) CR39 for Alpha-Particles Registration

    Microsoft Academic Search

    M. Gaber; A. A. Abou El-Khier; N. M. Fahmi

    1991-01-01

    The bulk etch rate, VB, in CR-39 was determined by using three methods at different etching conditions. The study was carried out for alpha-particles of energies ranging from 2.35 to 4.3 MeV at three different dissolved layers of 5.4, 7.2 and 9 ?m. Based on published REL-data, a very simple empirical formula was given to calculate REL for different ions

  9. Cross sections for the production of berylium isotopes from the 880 MeV alpha-particle bombardment of carbon

    Microsoft Academic Search

    J. Lestringuez; G. M. Raisbeck; F. Yiou; R. Bernas

    1971-01-01

    The cross sections for the production of 9Be and 10Be from the 880 MeV alpha-particle bombardment of carbon have been measured to be 10.6 +\\/- 1.7 and 6.5 +\\/- 1.4 mb. These values are essentially twice the high-energy proton cross sections. It is shown that the effect of the interstellar helium on the distribution of berylium isotopes in cosmic rays

  10. Ultra High Energy Particles

    E-print Network

    Burra G. Sidharth

    2011-07-22

    We revisit considerations of temporal order in relativistic effects, taking into account Heisenberg's Uncertainty Principle. We then use a formulation of relativistic Quantum Mechanical equations given by Feshbach and Villars to exhibit novel particle antiparticle effects.

  11. Mechanics and multiple-particle tracking microheterogeneity of alpha-actinin-cross-linked actin filament networks.

    PubMed Central

    Tseng, Y; Wirtz, D

    2001-01-01

    Cell morphology is controlled by the actin cytoskeleton organization and mechanical properties, which are regulated by the available contents in actin and actin regulatory proteins. Using rheometry and the recently developed multiple-particle tracking method, we compare the mechanical properties and microheterogeneity of actin filament networks containing the F-actin cross-linking protein alpha-actinin. The elasticity of F-actin/alpha-actinin networks increases with actin concentration more rapidly for a fixed molar ratio of actin to alpha-actinin than in the absence of alpha-actinin, for networks of fixed alpha-actinin concentration and of fixed actin concentration, but more slowly than theoretically predicted for a homogeneous cross-linked semiflexible polymer network. These rheological measurements are complemented by multiple-particle tracking of fluorescent microspheres imbedded in the networks. The distribution of the mean squared displacements of these microspheres becomes progressively more asymmetric and wider for increasing concentration in alpha-actinin and, to a lesser extent, for increasing actin concentration, which suggests that F-actin networks become progressively heterogeneous for increasing protein content. This may explain the slower-than-predicted rise in elasticity of F-actin/alpha-actinin networks. Together these in vitro results suggest that actin and alpha-actinin provides the cell with an unsuspected range of regulatory pathways to modulate its cytoskeleton's micromechanics and local organization in vivo. PMID:11509377

  12. Simple experimental method for alpha particle range determination in lead iodide films.

    PubMed

    Dmitriev, Yuri; Bennett, Paul R; Cirignano, Leonard J; Klugerman, Mikhail; Shah, Kanai S

    2007-05-01

    An experimental method for determining the range of alpha particles in films based on I-V(s) analysis has been suggested. The range of 5.5 MeV alpha particles in PbI(2) films determined by this technique is 30+/-5 microm, and this value is in agreement with the value calculated by SRIM (the stopping and range of ions in matter), r=24 microm in PbI(2). More than 100 I-V(s) of PbI(2) films with different thicknesses and quality have been analyzed, and the influence of alpha particle radiation on PbI(2) I-V(s) curves has been studied. Developed analytical methods (dependence of current density on electric field and conception of surface defects) were used, and the method limitations are discussed. It was shown that I-V(s) demonstrate the tendency to obey Ohm's law under alpha radiation. On the other hand, dark conductivity of the lead iodide films shows a typical impure character that can lead to an overestimation of the alpha particles' range in PbI(2) films. After films were exposed to alpha radiation, the dark resistivity and I-V shape of some films improved. Also, a weak decrease of the charge carrier concentration, due to a decrease of the "surface defect" concentration ("surface refining"), was registered after successive measurements of I-V(s). PMID:17552841

  13. Intense alpha-particle emitting crystallites in uranium mill wastes

    USGS Publications Warehouse

    Landa, E.R.; Stieff, L.R.; Germani, M.S.; Tanner, A.B.; Evans, J.R.

    1994-01-01

    Nuclear emulsion microscopy has demonstrated the presence of small, intense ??-particle emitting crystallites in laboratory-produced tailings derived from the sulfuric acid milling of uranium ores. The ??-particle activity is associated with the isotope pair 210Pb 210Po, and the host mineral appears to be PbSO4 occurring as inclusions in gypsum laths. These particles represent potential inhalation hazards at uranium mill tailings disposal areas. ?? 1994.

  14. An alpha particle measurement system using an energetic neutral helium beam in ITER (invited)

    SciTech Connect

    Sasao, M.; Tanaka, N.; Terai, K.; Kaneko, O. [Graduate school of Engineering, Tohoku University, Sendai 980-8579 (Japan); Kisaki, M.; Kobuchi, T.; Tsumori, K.; Okamoto, A.; Kitajima, S. [National Institute for Fusion Science, Toki, Gifu 509-5292 (Japan); Shinto, K. [IFMIF R and D Center, Japan Atomic Energy Agency, Rokkasho, Aomori 039-3212 (Japan); Wada, M. [Graduate School of Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321 (Japan)

    2012-02-15

    An energetic helium neutral beam is involved in the beam neutralization measurement system of alpha particles confined in a DT fusion plasma. A full size strong-focusing He{sup +} ion source (2 A, the beam radius of 11.3 mm, the beam energy less than 20 keV). Present strong-focusing He{sup +} ion source shows an emittance diagram separated for each beamlet of multiple apertures without phase space mixing, despite the space charge of a beamlet is asymmetric and the beam flow is non-laminar. The emittance of beamlets in the peripheral region was larger than that of center. The heat load to the plasma electrode was studied to estimate the duty factor for the ITER application.

  15. Solar flare protons and alpha particles during the last three solar cycles

    NASA Technical Reports Server (NTRS)

    Goswami, J. N.; Mcguire, R. E.; Reedy, R. C.; Lal, D.; Jha, R.

    1988-01-01

    This paper presents solar-flare-associated proton and alpha-particle fluxes determined for major events from October 1972 through March 1987 (the period that represents the last part of solar cycle 20 and the whole of solar cycle 21), using data obtained by detectors on board the IMP-7 and IMP-8 satellites, along with earlier obtained data for cycle 20. It was found that the average omnidirectional flux of protons with kinetic energy above 10 MeV for cycle 21 (64/sq cm per sec) is lower than the corresponding number for cycle 20 (92/sq cm per sec) and for the cycle 19 (378/sq cm per sec). No definitive correlation was found to exist between cycle-averaged solar flare proton fluxes and peak sunspot numbers.

  16. Determination of the radial gradient in the region 0.81-1.0 AU using both high- and low-energy /more than 10-GeV and more than 52-MeV/ detectors for the 1-AU monitor. [solar quiet measurements of alpha particles and protons

    NASA Technical Reports Server (NTRS)

    Sheldon, W. R.; Bukata, R. P.; Rao, U. R.

    1974-01-01

    A determination of the radial gradient for alpha particles (31-46 MeV/nuc) and protons with energies above 7.5 MeV and 44-77 MeV in the region 1.0-0.81 AU is presented for the solar-quiet year 1966. The determinations are based on data from the Pioneer 6 space probe. Two different detectors are used: the Deep River neutron monitor and measurements of low energy protons made on the IMP-C satellite. The average energy response of the Deep River monitor is 16 GeV, whereas the IMP-C data is for protons with energies above 50 MeV. The resulting radial gradient is found to be nearly zero for the alpha particles and slightly negative for the protons. The same qualitative results were found using the IMP-C data and the Deep River neutron monitor to measure the temporal variation in the cosmic ray intensity. The present analysis indicates that detectors over a wide range of energies are suitable for measuring the radial gradient, providing sufficient statistical precision is obtained to evaluate short-term modulation and the azimuthal separation of the detectors is not great.

  17. Alpha spectroscopy in CR-39 SSNTDs using energy simulation and matrix of energy equations for open field studies

    NASA Astrophysics Data System (ADS)

    Awad, E. M.; Soliman, A. A.; El-Samman, H. M.; Arafa, W. M.; Rammah, Y. S.

    2008-04-01

    Encouraged with the success of the matrix of energy equations in resolving alpha spectra for narrow energy band [O.A. Bondarenko, P.L. Salmon, D.L. Henshaw, A.P. Fews, Radiat. Meas. 26 (1996) 59; O.A. Bondarenko, P.L. Salmon, D.L. Henshaw, A.P. Fews, A.N. Ross, Nucl. Instrum. Methods A 369 (1996) 582] and wide energy band [E.M. Awad, A.A. Soliman, Y.S. Rammah, Phys. Lett. A 369 (5-6) (2007) 359] as well, the present work extends the applicability of this method to work out for open field studies. 241Am alpha source was used for irradiating CR-39 samples in air at normal temperature and pressure and at three different distances to obtain three different energies. Alpha particles were sorted to ten different bins according to their dip angle and the energy inside each bin was determined using alpha particle range-energy relation. Then, the energy matrix inside each bin was constructed using some selected calibration tracks. This matrix was composed of two track axes, the track minor axis (m) and diameter of etched out track end (d) of some selected elliptical tracks. The energy E in (m,d) coordinates was given by E=?i,j=02adkimkj. The adjusting parameters a were obtained by solving an over-determined system of energy equations using the SVD method. The three energies in each bin were well resolved.

  18. Destabilization of planar lipid bilayers by. cap alpha. particles from polonium-210

    SciTech Connect

    Nelson, G.A.

    1984-01-01

    A system for measuring the interacton between ..cap alpha.. particles from /sup 210/Polonium and planar lipid bilayers is described. Membrane capacitance and conductance were simultaneously measured with a voltage clamp. A micrometer advance mechanism was used to control the position of a /sup 210/Polonium source with respect to a bowed-out bilayer. Conductance records showed an abrupt failure of the bilayer when the source was approximately 30 microns or less from the bilayer. Comparisons of conductance noise characteristics just prior to membrane breakage and noise characteristics with a source - bilayer separation of 50 microns or greater showed no difference. The range of the ..cap alpha.. particles inferred from observations of membrane failure is consistent with the expected maximum range of approximately 35 microns for ..cap alpha.. particles from the particular gold-covered source in water. The breakage mechanism is not directly peroxide-mediated as experiments with added peroxide alone did not show significant alterations. The breakdown of lipid bilayers by ..cap alpha.. particles may be analogous to the observations in a set of experiments which showed ..cap alpha.. particle destabilization of surfactant films in air. Evidence supports the hypothesis that free radicals generated in the bilayer, as opposed to aqueous solution free radicals, are the most important agent for bilayer destabilization.

  19. Study of the absorption coefficient of alpha particles to lower hybrid waves in tokamak

    NASA Astrophysics Data System (ADS)

    Wang, Jianbing; Zhang, Xianmei; Yu, Limin; Zhao, Xiang

    2014-02-01

    Part of the energy of the Lower Hybrid (LH) waves may be absorbed by the ? particles via the so-called perpendicular landau damping mechanism, which depends on various parameters of fusion reactors and the LH waves. In this article, we calculate the absorption coefficient ?? of LH waves due to ? particles. Results show that, the ?? increases with the parallel refraction index n? while deceases with increasing the frequency of LH waves ?LH over a wide range. Higher background plasma temperature and toroidal magnetic field will increase the absorption, and there is a peak value of ?? when ne?8×1019m-3 for ITER-like scenario. The thermal corrections to the cold plasma dispersion relation will change the damping rate to a certain extent under some specific conditions. We have also evaluated the fraction of LH power absorbed by the alpha particles, ? ? 0.47% and 4.1% for an LH frequency of 5 GHz and 3.7 GHz respectively for ITER-like scenario. This work gives the effective reference for the choice of parameters of future fusion reactors.

  20. Study of the absorption coefficient of alpha particles to lower hybrid waves in tokamak

    SciTech Connect

    Wang, Jianbing, E-mail: zhangxm@ecust.edu.cn; Zhang, Xianmei, E-mail: zhangxm@ecust.edu.cn; Yu, Limin, E-mail: zhangxm@ecust.edu.cn; Zhao, Xiang, E-mail: zhangxm@ecust.edu.cn [Department of Physics, East China University of Science and Technology, P.O. Box 385, Shanghai 200237 (China)

    2014-02-12

    Part of the energy of the Lower Hybrid (LH) waves may be absorbed by the ? particles via the so-called perpendicular landau damping mechanism, which depends on various parameters of fusion reactors and the LH waves. In this article, we calculate the absorption coefficient ?{sub ?} of LH waves due to ? particles. Results show that, the ?{sub ?} increases with the parallel refraction index n{sub ?} while deceases with increasing the frequency of LH waves ?{sub LH} over a wide range. Higher background plasma temperature and toroidal magnetic field will increase the absorption, and there is a peak value of ?{sub ?} when n{sub e}?8×10{sup 19}m{sup ?3} for ITER-like scenario. The thermal corrections to the cold plasma dispersion relation will change the damping rate to a certain extent under some specific conditions. We have also evaluated the fraction of LH power absorbed by the alpha particles, ? ? 0.47% and 4.1% for an LH frequency of 5 GHz and 3.7 GHz respectively for ITER-like scenario. This work gives the effective reference for the choice of parameters of future fusion reactors.

  1. Coaxial charged particle energy analyzer

    NASA Technical Reports Server (NTRS)

    Kelly, Michael A. (Inventor); Bryson, III, Charles E. (Inventor); Wu, Warren (Inventor)

    2011-01-01

    A non-dispersive electrostatic energy analyzer for electrons and other charged particles having a generally coaxial structure of a sequentially arranged sections of an electrostatic lens to focus the beam through an iris and preferably including an ellipsoidally shaped input grid for collimating a wide acceptance beam from a charged-particle source, an electrostatic high-pass filter including a planar exit grid, and an electrostatic low-pass filter. The low-pass filter is configured to reflect low-energy particles back towards a charged particle detector located within the low-pass filter. Each section comprises multiple tubular or conical electrodes arranged about the central axis. The voltages on the lens are scanned to place a selected energy band of the accepted beam at a selected energy at the iris. Voltages on the high-pass and low-pass filters remain substantially fixed during the scan.

  2. Track reconstruction and performance of DRIFT directional dark matter detectors using alpha particles

    Microsoft Academic Search

    S. Burgos; J. Forbes; C. Ghag; M. Gold; V. A. Kudryavtsev; T. B. Lawson; D. Loomba; P. Majewski; D. Muna; A. St J. Murphy; G. G. Nicklin; S. M. Paling; A. Petkov; S. J. S. Plank; M. Robinson; N. Sanghi; N. J. T. Smith; D. P. Snowden-Ifft; N. J. C. Spooner; T. J. Sumner; J. Turk; E. Tziaferi; T. Tziaferi

    2008-01-01

    First results are presented from an analysis of data from the DRIFT-IIa and DRIFT-IIb directional dark matter detectors at Boulby Mine in which alpha particle tracks were reconstructed and used to characterise detector performance—an important step towards optimising directional technology. The drift velocity in DRIFT-IIa was 59.3ą0.2(stat)ą7.5(sys)ms-1 based on an analysis of naturally occurring alpha-emitting background. The drift velocity in

  3. Fire hose instability driven by alpha particles in the solar wind

    NASA Astrophysics Data System (ADS)

    Matteini, Lorenzo; Hellinger, Petr; Schwartz, Steven J.; Landi, Simone

    2015-04-01

    We discuss the dynamics of fire hose parallel instability driven by anisotropic alpha particles in a plasma with typical solar wind composition (n? = 5%ne). We show, for the first time, the liner and nonlinear dynamics of the instability by means of hybrid numeric simulations, highlighting its dependence on the main plasma parameters, including the relative drift between the alphas and the main proton population. Our results confirm that the parallel fire hose instability can be efficiently excited by anisotropic distribution of the less abundant alpha particles, even when the rest of the plasma (electrons and protons) is Maxwellian. Moreover, our finding suggest that the dynamics driven by the alphas can also influence the properties of the protons. In particular the instability is found to significantly affect the evolution of the alpha-proton drift, constraining its final intensity to values smaller than the local Alfvén speed, as observed in the solar wind far from the Sun. When simulations with both species initially anisotropic are performed, we find a coexistence of the fire hose wave activity excited by both ions, leading to final stable configurations which reflect the marginal stability state of each species. As a consequence, when observed in the commonly used (?||,T?/T||) plane, alpha particles and protons are seen to saturate in different regions of the parameter space. This property is in very good agreement with recent solar wind in situ observations and strongly suggests that those instabilities play a role in regulating the anisotropy solar wind ions.

  4. A study of the effects of MeV alpha particles in PE and PVDC

    SciTech Connect

    Evelyn, A.L.; Ila, D.; Zimmerman, R.L.; Bhat, K. [Center for Irradiation of Materials, Departments of Physics and Chemistry, Alabama AM University, P.O. Box 1447, Normal, Alabama 35762-1447 (United States); Poker, D.B.; Hensley, D.K. [Solid State Division, Oak Ridge National Laboratory, P.O. Box 2008, MS 6048, Oak Ridge, Tennessee 37831 (United States)

    1997-02-01

    We have mapped and studied the effects of MeV alpha-particle bombardment in polyvinylidene chloride (PVDC) and polyethylene (PE). We used 3.5 and 5.0 MeV alpha-particle incident beams and stacked polymer films to separate the contributing effects of the electronic ({var_epsilon}{sub e}) and nuclear ({var_epsilon}{sub n}) stopping powers. The electrical conductance and change in the chemical structures were measured by direct resistivity measurement, Raman microprobe, RBS and FTIR. The results indicate significant differences in the ({var_epsilon}{sub e}) and ({var_epsilon}{sub n}) effects at higher alpha-particle bombardment fluences. {copyright} {ital 1997 American Institute of Physics.}

  5. Rigidity-independent coronal propagation and escape of solar protons and alpha particles

    NASA Technical Reports Server (NTRS)

    Perron, C.; Domingo, V.; Reinhard, R.; Wenzel, K.-P.

    1978-01-01

    In a study of rigidity-independent coronal propagation processes, data on the azimuthal variation of the solar proton/alpha-particle ratio were obtained. Sources for the data included a statistical analysis of events observed by Heos-2, a comparative study of events recorded by both Heos-2 and Pioneer-10 and -11, and a multiday survey of individual events observed by Heos-2 and Pioneer-10. The statistical investigation of Heos-2 events reveals an increase of the lower value of the proton/alpha-particle ratio away from the well-connected region. The data from one or two spacecraft connected at different heliolongitudes indicates no azimuthal dependence of the proton/alpha-particle ratio. All the data appear to suggest rigidity-independent propagation or escape processes.

  6. Investigation of alpha particle induced single-event upsets in charge-coupled devices

    NASA Astrophysics Data System (ADS)

    Pepper, Gary T.; Fechete, Andrew

    1991-12-01

    The mechanisms for generation of single-event upsets (SEUs) in a linear charge coupled device (CCD) were studied through irradiation with monoenergetic 5.48 MeV alpha particles from a very low flux Am source. Spatial correlation (cluster analysis) of soft errors due to single alpha particle hits was demonstrated to be a necessary prerequisite for quantitative analysis of different SEU error-generating phenomena. The Texas Instruments TC-103 virtual phase CCD used in this study is shown to be sensitive to alpha particles not only in the vicinity of photosites as expected, but also in the transport CCDs. This latter effect may have adverse consequences for applications employing CCDs as position-sensitive ionizing radiation detectors. The techniques developed in this work for the analysis of one dimensional arrays is readily extensible to two dimensional CCD arrays.

  7. Prediction of Lung Cells Oncogenic Transformation for Induced Radon Progeny Alpha Particles Using Sugarscape Cellular Automata

    PubMed Central

    Baradaran, Samaneh; Maleknasr, Niaz; Setayeshi, Saeed; Akbari, Mohammad Esmaeil

    2014-01-01

    Background Alpha particle irradiation from radon progeny is one of the major natural sources of effective dose in the public population. Oncogenic transformation is a biological effectiveness of radon progeny alpha particle hits. The biological effects which has caused by exposure to radon, were the main result of a complex series of physical, chemical, biological and physiological interactions. The cellular and molecular mechanisms for radon-induced carcinogenesis have not been clear yet. Methods Various biological models, including cultured cells and animals, have been found useful for studying the carcinogenesis effects of radon progeny alpha particles. In this paper, sugars cape cellular automata have been presented for computational study of complex biological effect of radon progeny alpha particles in lung bronchial airways. The model has included mechanism of DNA damage, which has been induced alpha particles hits, and then formation of transformation in the lung cells. Biomarkers were an objective measure or evaluation of normal or abnormal biological processes. In the model, the metabolism rate of infected cell has been induced alpha particles traversals, as a biomarker, has been followed to reach oncogenic transformation. Results The model results have successfully validated in comparison with “in vitro oncogenic transformation data” for C3H 10T1/2 cells. This model has provided an opportunity to study the cellular and molecular changes, at the various stages in radiation carcinogenesis, involving human cells. Conclusion It has become well known that simulation could be used to investigate complex biomedical systems, in situations where traditional methodologies were difficult or too costly to employ. PMID:25250147

  8. Deceleration of Alpha Particles in the Solar Wind by Instabilities and the Rotational Force: Implications for Heating, Azimuthal Flow, and the Parker Spiral Magnetic Field

    NASA Astrophysics Data System (ADS)

    Verscharen, Daniel; Chandran, Benjamin D. G.; Bourouaine, Sofiane; Hollweg, Joseph V.

    2015-06-01

    Protons and alpha particles in the fast solar wind are only weakly collisional and exhibit a number of non-equilibrium features, including relative drifts between particle species. Two non-collisional mechanisms have been proposed for limiting differential flow between alpha particles and protons: plasma instabilities and the rotational force. Both mechanisms decelerate the alpha particles. In this paper, we derive an analytic expression for the rate {Q}{flow} at which energy is released by alpha-particle deceleration, accounting for azimuthal flow and conservation of total momentum. We show that instabilities control the deceleration of alpha particles at r\\lt {r}{crit}, and the rotational force controls the deceleration of alpha particles at r\\gt {r}{crit}, where {r}{crit}? 2.5 {AU} in the fast solar wind in the ecliptic plane. We find that {Q}{flow} is positive at r\\lt {r}{crit} and {Q}{flow}=0 at r?slant {r}{crit}, consistent with the previous finding that the rotational force does not lead to a release of energy. We compare the value of {Q}{flow} at r\\lt {r}{crit} with empirical heating rates for protons and alpha particles, denoted {Q}p and {Q}? , deduced from in situ measurements of fast-wind streams from the Helios and Ulysses spacecraft. We find that {Q}{flow} exceeds {Q}? at r\\lt 1 {AU}, and that {Q}{flow}/{Q}p decreases with increasing distance from the Sun from a value of about one at r = 0.29–0.42 AU to about 1/4 at 1 AU. We conclude that the continuous energy input from alpha-particle deceleration at r\\lt {r}{crit} makes an important contribution to the heating of the fast solar wind. We also discuss the implications of the alpha-particle drift for the azimuthal flow velocities of the ions and for the Parker spiral magnetic field.

  9. Annealing effect of the 6H-SiC semiconductor detector for alpha particles

    Microsoft Academic Search

    J. H. HA; S. M. Kang; S. H. Park; H. S. Kim; Y. H. Cho; J. H. Lee; N. H. Lee; J. B. Kim; Y. K. Kim

    2008-01-01

    Alpha-particle detectors based on 6H-SiC semiconductor were fabricated and their electrical and radiation performances were measured. Detector structure was Au\\/Ni\\/6H-SiC\\/Ni\\/Au multi-layer structure. The current–voltage characteristics of the SiC detectors were measured and the radiation response was evaluated by 238Pu with 5.5MeV alpha particles at room temperature in air. The 6H-SiC detectors were annealed by a rapid temperature annealing (RTA) device

  10. The emission probabilities of long range alpha particles from even-even 244-252Cm isotopes

    NASA Astrophysics Data System (ADS)

    Santhosh, K. P.; Krishnan, Sreejith; Priyanka, B.

    2014-10-01

    The alpha accompanied cold ternary fission of even-even 244Cm, 246Cm, 248Cm, 250Cm and 252Cm isotopes has been studied by taking the interacting barrier as the sum of the Coulomb and proximity potential with the fragments in equatorial configuration. The favorable fragment combinations are obtained from the cold reaction valley plot and by calculating the relative yield for the charge minimized fragments. In the alpha accompanied ternary fission of the 244Cm isotope, the highest yield is found for the fragment combination 110Ru+4He+130Sn, which possess near doubly magic nuclei 130Sn. For the ternary fission of 246Cm, 248Cm, 250Cm and 252Cm isotopes with 4He as the light charged particle, the highest yield is obtained for the fragment combination with doubly magic nuclei 132Sn as the heavier fragment. The emission probabilities and kinetic energies of long range alpha particles have been computed for the 242,244,246,248Cm isotopes and are found to be in good agreement with the experimental data. The relative yields for the 4He accompanied ternary fission (equatorial and collinear) of 242-252Cm isotopes are compared with the corresponding yield for binary fission. The effect of deformation and orientation of fragments in the 4He accompanied ternary fission of 244-252Cm isotopes are studied. Our study reveals that the ground state deformation has as an important role in the alpha accompanied ternary fission as that of the shell effect.

  11. The emission probabilities of long range alpha particles from even-even 244-252Cm isotopes

    E-print Network

    K. P. Santhosh; Sreejith Krishnan; B. Priyanka

    2014-09-02

    The alpha accompanied cold ternary fission of even-even 244Cm, 246Cm, 248Cm, 250Cm and 252Cm isotopes have been studied by taking the interacting barrier as the sum of Coulomb and proximity potential with the fragments in equatorial configuration. The favorable fragment combinations are obtained from the cold reaction valley plot and by calculating the relative yield for the charge minimized fragments. In the alpha accompanied ternary fission of 244Cm isotope, the highest yield is found for the fragment combination 110Ru+4He+130Sn, which possess near doubly magic nuclei 130Sn. For the ternary fission of 246Cm, 248Cm, 250Cm and 252Cm isotopes with 4He as light charged particle, the highest yield is obtained for the fragment combination with doubly magic nuclei 132Sn as the heavier fragment. The emission probabilities and kinetic energies of long range alpha particle have been computed for the 242,244,246,248Cm isotopes and are found to be in good agreement with the experimental data. The relative yields for the 4He accompanied ternary fission (equatorial and collinear) of 242-252Cm isotopes are compared with the corresponding yield for binary fission. The effect of deformation and orientation of fragments in the 4He accompanied ternary fission of 244-252Cm isotopes are studied. Our study reveals that the ground state deformation has an important role in the alpha accompanied ternary fission as that of shell effect.

  12. The role of nuclear reactions and {alpha}-particle transport in the dynamics of inertial confinement fusion capsules

    SciTech Connect

    Garnier, Josselin [Laboratoire de Probabilites et Modeles Aleatoires and Laboratoire Jacques-Louis Lions, Universite Paris VII, 2 Place Jussieu, 75251 Paris Cedex 05 (France); Cherfils-Clerouin, Catherine [Commissariat a l'Energie Atomique, Direction des Applications Militaires, Boite Postale 12, 91680 Bruyeres le Chatel (France)

    2008-10-15

    This paper is devoted to the study of the deceleration phase of inertial confinement capsules. The purpose is to obtain a zero-dimensional model that has the form of a closed system of ordinary differential equations for the main hydrodynamic quantities. The model takes into account the energy released by nuclear reactions, a nonlocal model for the {alpha}-particle energy deposition process, and radiation loss by electron bremsstrahlung. The asymptotic analysis is performed in the case of a strong temperature dependence of the thermal conductivity. We finally study the beginning of the expansion phase after stagnation to derive an ignition criterion.

  13. Characterization of mono-energetic charged-particle radiography for high energy density physics experiments

    E-print Network

    Manuel, Mario John-Errol

    2008-01-01

    Charged-particle radiography, specifically protons and alphas, has recently been used to image various High-Energy-Density Physics objects of interest, including Inertial Confinement Fusion capsules during their implosions, ...

  14. Cross section balance in the 14N + 159Tb reaction and the origin of fast alpha particles

    NASA Astrophysics Data System (ADS)

    Siemssen, R. H.; Balster, G. J.; Wilschut, H. W.; Bond, P. D.; Crouzen, P. C. N.; Goldhoorn, P. B.; Shukui, Han; Sujkowski, Z.

    1985-10-01

    Exclusive cross sections have been obtained from particle-K X-ray coincidence data measured at 236 MeV for ejectiles ranging from 4He to 15N. Production cross sections for primary fragments and alpha particle multiplicities associated with different channels have been deduced. The major fraction of the alpha particles appears to originate from inelastic (damped) processes in which only light particles with Z ? 2 are emitted.

  15. The 106Cd(alpha,alpha)106Cd elastic scattering in a wide energy range for gamma-process studies

    E-print Network

    Ornelas, A; Mohr, P; Galaviz, D; Fülöp, Zs; Gyürky, Gy; Máté, Z; Rauscher, T; Somorjai, E; Sonnabend, K; Zilges, A

    2015-01-01

    Alpha elastic scattering angular distributions of the 106Cd(alpha,alpha)106Cd reaction were measured at three energies around the Coulomb barrier to provide a sensitive test for the alpha + nucleus optical potential parameter sets. Furthermore, the new high precision angular distributions, together with the data available from the literature were used to study the energy dependence of the locally optimized {\\alpha}+nucleus optical potential in a wide energy region ranging from E_Lab = 27.0 MeV down to 16.1 MeV. The potentials under study are a basic prerequisite for the prediction of alpha-induced reaction cross sections and thus, for the calculation of stellar reaction rates used for the astrophysical gamma process. Therefore, statistical model predictions using as input the optical potentials discussed in the present work are compared to the available 106Cd + alpha cross section data.

  16. The 106Cd(alpha,alpha)106Cd elastic scattering in a wide energy range for gamma-process studies

    E-print Network

    A. Ornelas; G. G. Kiss; P. Mohr; D. Galaviz; Zs. Fülöp; Gy. Gyürky; Z. Máté; T. Rauscher; E. Somorjai; K. Sonnabend; A. Zilges

    2015-04-29

    Alpha elastic scattering angular distributions of the 106Cd(alpha,alpha)106Cd reaction were measured at three energies around the Coulomb barrier to provide a sensitive test for the alpha + nucleus optical potential parameter sets. Furthermore, the new high precision angular distributions, together with the data available from the literature were used to study the energy dependence of the locally optimized {\\alpha}+nucleus optical potential in a wide energy region ranging from E_Lab = 27.0 MeV down to 16.1 MeV. The potentials under study are a basic prerequisite for the prediction of alpha-induced reaction cross sections and thus, for the calculation of stellar reaction rates used for the astrophysical gamma process. Therefore, statistical model predictions using as input the optical potentials discussed in the present work are compared to the available 106Cd + alpha cross section data.

  17. CURRENT DRIVE BY LOWER HYBRID WAVES IN THE PRESENCE OF ENERGETIC ALPHA PARTICLES

    E-print Network

    energetic reactor plasma and, if they do, the wave power may be absorbed by alpha particles rather than not penetrate into the centre of the more energetic reactor plasma, and, second, if they do, as pointed out, reactor plasma, because there are sufficient hot electrons at a distance from the plasma centre

  18. Boron compounds as a dominant source of alpha particles in semiconductor devices

    Microsoft Academic Search

    Robert Baumann; Tim Hossain; Shinya Murata; Hideki Kitagawa

    1995-01-01

    The interaction of cosmic ray neutrons and boron is demonstrated as the dominant source of alpha particles and other radiations in electronic devices utilizing borophosphosilicate glass (BPSG). A simple process modification is proposed to significantly reduce this intense source of ionizing radiation without compromising the reflow and passivation properties of BPSG.

  19. PPPL-3164 -Preprint Date: January 1996, UC-420 Alpha Particle Losses from Tokamak Fusion Test Reactor

    E-print Network

    Reactor Deuterium-Tritium Plasmas D. S. Darrow, S. J. Zweben, S. Batha*, R. V. Budny, C. E. Bush, Z. Chang. S. Medley, M. Murakami, M. Petrovś, C. K. Phillips, M. H. Redi, E. Ruskov§, D. A. Spong, E. J on tokamak reactor viability, the loss of deuterium-tritium alpha particles from the Tokamak Fusion Test

  20. alpha-particle knock-on signature in the neutron emission of DT plasmas

    Microsoft Academic Search

    L. Ballabio; G. Gorini; J. Käautllne

    1997-01-01

    The fast alpha-particle kinetic effects in fusion plasmas of deuterium and tritium are studied in the perspective that they can give rise to minority populations of fast fuel ions. The resulting modification of the neutron emission spectrum is computed for a plasma in the state of steady thermonuclear burn of conditions similar to those envisaged for the planned ITER tokamak.

  1. Depleted uranium-catalyzed oxidative DNA damage: absence of significant alpha particle decay

    Microsoft Academic Search

    Alexandra C. Miller; Michael Stewart; Kia Brooks; Lin Shi; Natalie Page

    2002-01-01

    Depleted uranium (DU) is a dense heavy metal used primarily in military applications. Published data from our laboratory have demonstrated that DU exposure in vitro to immortalized human osteoblast cells (HOS) is both neoplastically transforming and genotoxic. DU possesses both a radiological (alpha particle) and a chemical (metal) component. Since DU has a low-specific activity in comparison to natural uranium,

  2. The new Athena alpha particle X-ray spectrometer for the Mars Exploration Rovers

    Microsoft Academic Search

    R. Rieder; R. Gellert; J. Brückner; G. Klingelhöfer; G. Dreibus; A. Yen; S. W. Squyres

    2003-01-01

    The new alpha particle X-ray spectrometer (APXS) is part of the Athena payload of the two Mars Exploration Rovers (MER). The APXS sensor head is attached to the turret of the instrument deployment device (IDD) of the rover. The APXS is a very light-weight instrument for determining the major and minor elemental composition of Martian soils, rocks, and other geological

  3. Differential Flow Between Solar Wind Protons and Alpha Particles: First WIND Observations

    E-print Network

    Richardson, John

    made using the SWE Faraday cup detectors on the WIND p spacecraft are reported. Some overall trends solar wind. e e SWE includes two Faraday cup detectors for measuring th nergy-per-charge spectrum of solar wind protons and alpha - u particles [Ogilvie et al., 1995]. The Faraday cups provide meas rements

  4. Environmental Radioactivity 60 (2002) 293305 Absorbed dose delivered by alpha particles

    E-print Network

    Yu, K.N.

    2002-01-01

    fraction of alpha particles in sensitive cells of the tracheobronchial tree obtained by NRC and ICRP are in good agreement with those obtained previously by NRC and ICRP66. Using the semi-analytical method by NRC and ICRP, respectively, have been satisfactorily reproduced. Using the tissue stopping power

  5. Low temperature alpha particle irradiation of a STAR1000 CMOS APS

    Microsoft Academic Search

    G. R. Hopkinson; A. Mohammadzadeh

    2007-01-01

    A STAR1000 CMOS active pixel sensor was irradiated with alpha particles at -130degC and dark current measurements were made at temperatures up to 25degC. Approximately 90% of dark current spikes were seen to anneal near room temperature. This implies that room temperature irradiations will not give a good estimate of on-orbit effects for cooled applications.

  6. Low Temperature Alpha Particle Irradiation of a STAR1000 CMOS APS

    Microsoft Academic Search

    G. R. Hopkinson; A. Mohammadzadeh

    2008-01-01

    A STAR1000 CMOS active pixel sensor was irradiated with alpha particles at -130deg C and dark current measurements were made at temperatures up to 25degC. Approximately 90% of dark current spikes were seen to anneal near room temperature. This implies that room temperature irradiations will not give a good estimate of on-orbit effects for cooled applications.

  7. BJT detector with FPGA-based read-out for alpha particle monitoring

    Microsoft Academic Search

    V. Tyzhnevyi; G.-F. Dalla Betta; L. Rovati; G. Verzellesi; N. Zorzi

    2011-01-01

    In this work we introduce a new prototype of readout electronics (ALPHADET), which was designed for an alpha-particle detection system based on a bipolar junction transistor (BJT) detector. The system uses an FPGA, which provides many advantages at the stage of prototyping and testing the detector. The main design and electrical features of the board are discussed in this paper,

  8. Fabrication of substrates with curvature for cell cultivation by alpha-particle irradiation and chemical etching of PADC films

    E-print Network

    Yu, K.N.

    . As an application, the present work studied mechanosensing of substrate curvature by epithelial cells (HeLa cellsFabrication of substrates with curvature for cell cultivation by alpha-particle irradiation online 16 February 2012 Keywords: Microfabrication Cell-culture substrates Alpha particles PADC Substrate

  9. Studying effects of Magnolol on alpha-particle induced bystander effects using PADC-film based dishes

    E-print Network

    Yu, K.N.

    Studying effects of Magnolol on alpha-particle induced bystander effects using PADC-film based May 2009 Accepted 17 October 2009 Keywords: Bystander effect Alpha-particle CHO cells Magnolol PADC irradiated directly by ionizing radiation. In the present paper, the effects of Magnolol, an extract from

  10. Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation status.

    PubMed

    Lyckesvärd, Madeleine Nordén; Delle, Ulla; Kahu, Helena; Lindegren, Sture; Jensen, Holger; Bäck, Tom; Swanpalmer, John; Elmroth, Kecke

    2014-07-01

    Childhood exposure to ionizing radiation increases the risk of developing thyroid cancer later in life and this is suggested to be due to higher proliferation of the young thyroid. The interest of using high-LET alpha particles from Astatine-211 ((211)At), concentrated in the thyroid by the same mechanism as (131)I [1], in cancer treatment has increased during recent years because of its high efficiency in inducing biological damage and beneficial dose distribution when compared to low-LET radiation. Most knowledge of the DNA damage response in thyroid is from studies using low-LET irradiation and much less is known of high-LET irradiation. In this paper we investigated the DNA damage response and biological consequences to photons from Cobolt-60 ((60)Co) and alpha particles from (211)At in normal primary thyrocytes of different cell cycle status. For both radiation qualities the intensity levels of ?H2AX decreased during the first 24h in both cycling and stationary cultures and complete repair was seen in all cultures but cycling cells exposed to (211)At. Compared to stationary cells alpha particles were more harmful for cycling cultures, an effect also seen at the pChk2 levels. Increasing ratios of micronuclei per cell nuclei were seen up to 1Gy (211)At. We found that primary thyrocytes were much more sensitive to alpha particle exposure compared with low-LET photons. Calculations of the relative biological effectiveness yielded higher RBE for cycling cells compared with stationary cultures at a modest level of damage, clearly demonstrating that cell cycle status influences the relative effectiveness of alpha particles. PMID:24769180

  11. Lung cancer risk from exposure to alpha particles and inhalation of other pollutants in rats

    SciTech Connect

    Burns, F.J.

    1990-01-01

    The goal of these experiments is to establish a quantitative correlation between early DNA damage and cancer incidence in a way that would be helpful for assessing the carcinogenic risk of radon alone or in combination with specific indoor pollutants. Rat tracheal epithelium has been exposed in vivo to {sup 210}Po alpha particles in the presence and absence of NO{sub 2} or cigarette smoke. The major accomplishments so far are: the design and implementation of a tracheal implant to simulate radon alpha particle exposure, the measurement of DNA breaks in a small 7.0 mm segment of the trachea exposed to external x-irradiation, the measurement of the rate of repair of the x-ray induced tracheal DNA strand breaks, the measurement of DNA strand breaks following inhalation of cigarette smoke or NO{sub 2}, the measurement of tracheal DNA stand breaks following exposure to high doses {sup 210}Po alpha particle radiation, the assessment of the amount of mucous in the goblet cells and in the underlying mucous glands. So far we have been unable to detect DNA strand breaks in the tracheal epithelium as a result of exposure to NO{sub 2} cigarette smoke or {sup 210}Po alpha particles. We have developed a simple artificial' trachea consisting of rat tracheal epithelial cells growing on a basement membrane coated millipore filter. Experiments are proposed to utilize these artificial tracheas to eliminate the potential interference of increased mucous secretion and/or inflammation that can significantly affect the radiation dose from the alpha particles. 61 refs., 17 figs.

  12. Production of actinium-225 for alpha particle mediated radioimmunotherapy.

    PubMed

    Boll, Rose A; Malkemus, Dairin; Mirzadeh, Saed

    2005-05-01

    The initial clinical trials for treatment of acute myeloid leukemia have demonstrated the effectiveness of the alpha emitter (213)Bi in killing cancer cells. Bismuth-213 is obtained from a radionuclide generator system from decay of 10-days (225)Ac parent. Recent pre-clinical studies have also shown the potential application of both (213)Bi, and the (225)Ac parent radionuclide in a variety of cancer systems and targeted radiotherapy. This paper describes our five years of experience in production of (225)Ac in partial support of the on-going clinical trials. A four-step chemical process, consisting of both anion and cation exchange chromatography, is utilized for routine separation of carrier-free (225)Ac from a mixture of (228)Th, (229)Th and (232)Th. The separation of Ra and Ac from Th is achieved using the marcoporous anion exchange resin MP1 in 8M HNO(3) media. Two sequential MP1/NO(3) columns provide a separation factor of approximately 10(6) for Ra and Ac from Th. The separation of Ac from Ra is accomplished on a low cross-linking cation exchange resin AG50-X4 using 1.2M HNO(3) as eluant. Two sequential AG50/NO(3) columns provide a separation factor of approximately 10(2) for Ac from Ra. A 60-day processing schedule has been adopted in order to reduce the processing cost and to provide the highest levels of (225)Ac possible. Over an 8-week campaign, a total of approximately 100 mCi of (225)Ac (approximately 80% of the theoretical yield) is shipped in 5-6 batches, with the first batch typically consisting of approximately 50 mCi. After the initial separation and purification of Ac, the Ra pool is re-processed on a bi-weekly schedule or as needed to provide smaller batches of (225)Ac. The averaged radioisotopic purity of the (225)Ac was 99.6 +/- 0.7% with a (225)Ra content of < or =0.6%, and an average (229)Th content of (4(-4)(+5)) x 10(-5)%. PMID:15763472

  13. Map model for nonlinear alpha particle interaction with toroidal Alfven waves

    SciTech Connect

    Berk, H.L.; Breizman, B.N.; Ye, H.

    1992-09-01

    A map model has been developed for studying the nonlinear interaction of alpha particles with the toroidal Alfven eigenmodes. The map is constructed by assuming a linear interaction during a single poloidal transit, which allows the study of the nonlinear interaction over many transits. By using this map, analytic expressions are obtained for the particle nonlinear bounce frequency, and the wave amplitude threshold for the onset of particle orbit stochasticity. The map model can also facilitate self-consistent simulations which incorporate the time variation of the waves.

  14. Neoclassical Simulations of Fusion Alpha Particles in Pellet Charge Exchange Experiments on the Tokamak Fusion Test Reactor

    SciTech Connect

    Batha, S.H.; Budny, R.V.; Darrow, D.S.; Levinton, F.M.; Redi, M.H.; et al

    1999-02-01

    Neoclassical simulations of alpha particle density profiles in high fusion power plasmas on the Tokamak Fusion Test Reactor (TFTR) [Phys. Plasmas 5 (1998) 1577] are found to be in good agreement with measurements of the alpha distribution function made with a sensitive active neutral particle diagnostic. The calculations are carried out in Hamiltonian magnetic coordinates with a fast, particle-following Monte Carlo code which includes the neoclassical transport processes, a recent first-principles model for stochastic ripple loss and collisional effects. New global loss and confinement domain calculations allow an estimate of the actual alpha particle densities measured with the pellet charge exchange diagnostic.

  15. Electronic Properties of DNA-Based Schottky Barrier Diodes in Response to Alpha Particles.

    PubMed

    Al-Ta'ii, Hassan Maktuff Jaber; Periasamy, Vengadesh; Amin, Yusoff Mohd

    2015-01-01

    Detection of nuclear radiation such as alpha particles has become an important field of research in recent history due to nuclear threats and accidents. In this context; deoxyribonucleic acid (DNA) acting as an organic semiconducting material could be utilized in a metal/semiconductor Schottky junction for detecting alpha particles. In this work we demonstrate for the first time the effect of alpha irradiation on an Al/DNA/p-Si/Al Schottky diode by investigating its current-voltage characteristics. The diodes were exposed for different periods (0-20 min) of irradiation. Various diode parameters such as ideality factor, barrier height, series resistance, Richardson constant and saturation current were then determined using conventional, Cheung and Cheung's and Norde methods. Generally, ideality factor or n values were observed to be greater than unity, which indicates the influence of some other current transport mechanism besides thermionic processes. Results indicated ideality factor variation between 9.97 and 9.57 for irradiation times between the ranges 0 to 20 min. Increase in the series resistance with increase in irradiation time was also observed when calculated using conventional and Cheung and Cheung's methods. These responses demonstrate that changes in the electrical characteristics of the metal-semiconductor-metal diode could be further utilized as sensing elements to detect alpha particles. PMID:26007733

  16. Electronic Properties of DNA-Based Schottky Barrier Diodes in Response to Alpha Particles

    PubMed Central

    Al-Ta’ii, Hassan Maktuff Jaber; Periasamy, Vengadesh; Amin, Yusoff Mohd

    2015-01-01

    Detection of nuclear radiation such as alpha particles has become an important field of research in recent history due to nuclear threats and accidents. In this context; deoxyribonucleic acid (DNA) acting as an organic semiconducting material could be utilized in a metal/semiconductor Schottky junction for detecting alpha particles. In this work we demonstrate for the first time the effect of alpha irradiation on an Al/DNA/p-Si/Al Schottky diode by investigating its current-voltage characteristics. The diodes were exposed for different periods (0–20 min) of irradiation. Various diode parameters such as ideality factor, barrier height, series resistance, Richardson constant and saturation current were then determined using conventional, Cheung and Cheung’s and Norde methods. Generally, ideality factor or n values were observed to be greater than unity, which indicates the influence of some other current transport mechanism besides thermionic processes. Results indicated ideality factor variation between 9.97 and 9.57 for irradiation times between the ranges 0 to 20 min. Increase in the series resistance with increase in irradiation time was also observed when calculated using conventional and Cheung and Cheung’s methods. These responses demonstrate that changes in the electrical characteristics of the metal-semiconductor-metal diode could be further utilized as sensing elements to detect alpha particles. PMID:26007733

  17. Lost alpha-particle diagnostics from a D-T plasma by using nuclear reactions

    SciTech Connect

    Sasao, Mamiko [Organization for Research Initiative and Development, Doshisha University, Kyotanabe, Kyoto 610-0321 (Japan); Wada, Motoi [Graduate School of Science and Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321 (Japan); Isobe, Mitsutaka [National Institute for Fusion Science, Toki Gifu 509-5292 (Japan)

    2014-08-21

    Among various methods proposed for alpha-particles loss measurement, we studied on those by measuring gamma rays of three cases, from (1) nuclear reactions induced by alpha particles, (2) those from short-life-time activities and (3) those from long-life-time activities induced by alpha particles. The time evolution of local alpha flux may possibly be measured by using the {sup 9}Be (a, n) {sup 12}C reaction (1). Using the same system, but with a target set up close to the first wall, activation measurement on site right after turning-off the discharge is possible (2). Nuclear reaction, {sup 25}Mg (a, p) {sup 28}Al, that produce radioisotopes of short lifetime of 2.2 minutes in one of the best candidates. As to the activation to a long lifetime (3), it is predicted that the gamma ray yield from {sup 19}F (a, n) {sup 22}Na reaction is enough for the measurement at the reactor site.

  18. Charged-particle mutagenesis 2. Mutagenic effects of high energy charged particles in normal human fibroblasts

    NASA Technical Reports Server (NTRS)

    Chen, D. J.; Tsuboi, K.; Nguyen, T.; Yang, T. C.

    1994-01-01

    The biological effects of high Linear Energy Transfer (LET) charged particles are a subject of great concern with regard to the prediction of radiation risk in space. In this report, mutagenic effects of high LET charged particles are quantitatively measured using primary cultures of human skin fibroblasts, and the spectrum of induced mutations are analyzed. The LET of the charged particles ranged from 25 KeV/micrometer to 975 KeV/micrometer with particle energy (on the cells) between 94-603 MeV/u. The X-chromosome linked hypoxanthine guanine phosphoribosyl transferase (hprt) locus was used as the target gene. Exposure to these high LET charged particles resulted in exponential survival curves; whereas, mutation induction was fitted by a linear model. The Relative Biological Effect (RBE) for cell-killing ranged from 3.73 to 1.25, while that for mutant induction ranged from 5.74 to 0.48. Maximum RBE values were obtained at the LET of 150 keV/micrometer. The inactivation cross-section (alpha i) and the action cross-section for mutant induction (alpha m) ranged from 2.2 to 92.0 sq micrometer and 0.09 to 5.56 x 10(exp -3) sq micrometer respectively. The maximum values were obtained by Fe-56 with an LET of 200 keV/micrometer. The mutagenicity (alpha m/alpha i) ranged from 2.05 to 7.99 x 10(exp -5) with the maximum value at 150 keV/micrometer. Furthermore, molecular analysis of mutants induced by charged particles indicates that higher LET beams are more likely to cause larger deletions in the hprt locus.

  19. Ionization and scintillation response of high-pressure xenon gas to alpha particles

    NASA Astrophysics Data System (ADS)

    Álvarez, V.; Borges, F. I. G.; Cárcel, S.; Cebrián, S.; Cervera, A.; Conde, C. A. N.; Dafni, T.; Díaz, J.; Egorov, M.; Esteve, R.; Evtoukhovitch, P.; Fernandes, L. M. P.; Ferrario, P.; Ferreira, A. L.; Freitas, E. D. C.; Gehman, V. M.; Gil, A.; Goldschmidt, A.; Gómez, H.; Gómez-Cadenas, J. J.; González-Díaz, D.; Gutiérrez, R. M.; Hauptman, J.; Hernando Morata, J. A.; Herrera, D. C.; Irastorza, I. G.; Jinete, M. A.; Labarga, L.; Laing, A.; Liubarsky, I.; Lopes, J. A. M.; Lorca, D.; Losada, M.; Luzón, G.; Marí, A.; Martín-Albo, J.; Miller, T.; Moiseenko, A.; Monrabal, F.; Monteiro, C. M. B.; Mora, F. J.; Moutinho, L. M.; Muńoz Vidal, J.; Natal da Luz, H.; Navarro, G.; Nebot-Guinot, M.; Nygren, D.; Oliveira, C. A. B.; Palma, R.; Pérez, J.; Pérez Aparicio, J. L.; Renner, J.; Ripoll, L.; Rodríguez, A.; Rodríguez, J.; Santos, F. P.; dos Santos, J. M. F.; Seguí, L.; Serra, L.; Shuman, D.; Simón, A.; Sofka, C.; Sorel, M.; Toledo, J. F.; Tomás, A.; Torrent, J.; Tsamalaidze, Z.; Vázquez, D.; Veloso, J. F. C. A.; Webb, R.; White, J. T.; Yahlali, N.

    2013-05-01

    High-pressure xenon gas is an attractive detection medium for a variety of applications in fundamental and applied physics. In this paper we study the ionization and scintillation detection properties of xenon gas at 10 bar pressure. For this purpose, we use a source of alpha particles in the NEXT-DEMO time projection chamber, the large scale prototype of the NEXT-100 neutrinoless double beta decay experiment, in three different drift electric field configurations. We measure the ionization electron drift velocity and longitudinal diffusion, and compare our results to expectations based on available electron scattering cross sections on pure xenon. In addition, two types of measurements addressing the connection between the ionization and scintillation yields are performed. On the one hand we observe, for the first time in xenon gas, large event-by-event correlated fluctuations between the ionization and scintillation signals, similar to that already observed in liquid xenon. On the other hand, we study the field dependence of the average scintillation and ionization yields. Both types of measurements may shed light on the mechanism of electron-ion recombination in xenon gas for highly-ionizing particles. Finally, by comparing the response of alpha particles and electrons in NEXT-DEMO, we find no evidence for quenching of the primary scintillation light produced by alpha particles in the xenon gas.

  20. Alpha-particle-induced luminescence of rare-earth-doped Y 2O 3 nanophosphors

    NASA Astrophysics Data System (ADS)

    Cress, Cory D.; Redino, Christopher S.; Landi, Brian J.; Raffaelle, Ryne P.

    2008-08-01

    The feasibility of utilizing Y 2O 3:Tb 3+ and Y 2O 3:Eu 3+ as radioluminescent nanophosphors under alpha-particle excitation is investigated. Materials synthesized by the urea homogeneous precipitation method were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). The XRD analysis of as-produced precipitates and nanophosphors fired at temperatures ranging from 950 to 1100 °C indicated the presence of highly crystalline cubic Y 2O 3 with crystallite sizes of ˜40 nm. SEM and TEM analysis revealed that particles with average diameters of ˜200 nm and comprised of ˜40 nm grains were obtained. High-resolution radioluminescence and photoluminescence spectra were used to investigate the unwanted radioluminescence saturation effects associated with the high ionization rate of alpha-particles. Additionally, the radioluminescence intensity as a function of rare-earth ion dopant concentration is investigated for these materials under alpha-particle excitation. The prospect for utilizing these materials as intermediate absorbers in indirect-conversion radioisotope batteries is discussed.

  1. Alpha Channeling in Rotating Plasma with Stationary Waves

    SciTech Connect

    A. Fetterman and N.J. Fisch

    2010-02-15

    An extension of the alpha channeling effect to supersonically rotating mirrors shows that the rotation itself can be driven using alpha particle energy. Alpha channeling uses radiofrequency waves to remove alpha particles collisionlessly at low energy. We show that stationary magnetic fields with high n? can be used for this purpose, and simulations show that a large fraction of the alpha energy can be converted to rotation energy.

  2. Production of the therapeutic radionuclides 193mPt and 195mPt with high specific activity via alpha-particle-induced reactions on 192Os.

    PubMed

    Hilgers, K; Coenen, H H; Qaim, S M

    2008-04-01

    For the production of therapy-relevant radionuclides (193m)Pt (T(1/2)=4.33 d) and (195m)Pt (T(1/2)=4.03 d) with a high specific activity, the (192)Os(alpha,n)(195m)Pt and (192)Os(alpha,3n)(193m)Pt nuclear reactions were investigated for the first time from their respective thresholds up to 28 MeV. Thin samples of enriched (192)Os were prepared by electrodeposition on Ni, and the conventional stacked-foil technique was used for cross-section measurements. The calculated thick target yields were found to be 0.013 MBq/microA h for the (192)Os(alpha,n)(195m)Pt reaction in the energy range of E(alpha)=24-->18 MeV, and 0.25 MBq/microA h for the (192)Os(alpha,3n)(193m)Pt reaction in the energy range of E(alpha)=28-->24 MeV. The two radionuclides could not be detected in the interactions of (3)He particles with (192)Os. A production method involving high-current alpha-particle irradiation of enriched (192)Os and efficient chemical separation of radioplatinum was developed. Batch yields of about 1 MBq (195m)Pt and 8.7 MBq (193m)Pt were achieved. Compared to the reactor production these batch yields are very low, but the (192)Os(alpha,n)(195m)Pt and (192)Os(alpha,3n)(193m)Pt reactions are superior with respect to the specific activity of the products which is higher by two orders of magnitude. PMID:18083038

  3. Calculation of effective atomic number and electron density of essential biomolecules for electron, proton, alpha particle and multi-energetic photon interactions

    NASA Astrophysics Data System (ADS)

    Kurudirek, Murat; Onaran, Tayfur

    2015-07-01

    Effective atomic numbers (Zeff) and electron densities (Ne) of some essential biomolecules have been calculated for total electron interaction, total proton interaction and total alpha particle interaction using an interpolation method in the energy region 10 keV-1 GeV. Also, the spectrum weighted Zeff for multi-energetic photons has been calculated using Auto-Zeff program. Biomolecules consist of fatty acids, amino acids, carbohydrates and basic nucleotides of DNA and RNA. Variations of Zeff and Ne with kinetic energy of ionizing charged particles and effective photon energies of heterogeneous sources have been studied for the given materials. Significant variations in Zeff and Ne have been observed through the entire energy region for electron, proton and alpha particle interactions. Non-uniform variation has been observed for protons and alpha particles in low and intermediate energy regions, respectively. The maximum values of Zeff have found to be in higher energies for total electron interaction whereas maximum values have found to be in relatively low energies for total proton and total alpha particle interactions. When it comes to the multi-energetic photon sources, it has to be noted that the highest Zeff values were found at low energy region where photoelectric absorption is the pre-dominant interaction process. The lowest values of Zeff have been shown in biomolecules such as stearic acid, leucine, mannitol and thymine, which have highest H content in their groups. Variation in Ne seems to be more or less the same with the variation in Zeff for the given materials as expected.

  4. PGC-1{alpha}: a key regulator of energy metabolism

    NSDL National Science Digital Library

    Huiyun Liang (University of Texas Health Science Center Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies)

    2006-12-01

    Peroxisome proliferator-activated receptor-{gamma} coactivator (PGC)-1{alpha} is a member of a family of transcription coactivators that plays a central role in the regulation of cellular energy metabolism. This makes it an inviting target for pharmacological intervention in the treatment of obesity and Type 2 diabetes.

  5. Charged-particle mutagenesis II. Mutagenic effects of high energy charged particles in normal human fibroblasts

    NASA Technical Reports Server (NTRS)

    Chen, D. J.; Tsuboi, K.; Nguyen, T.; Yang, T. C.

    1994-01-01

    The biological effects of high LET charged particles are a subject of great concern with regard to the prediction of radiation risk in space. In this report, mutagenic effects of high LET charged particles are quantitatively measured using primary cultures of human skin fibroblasts, and the spectrum of induced mutations are analyzed. The LET of the charged particles ranged from 25 KeV/micrometer to 975 KeV/micrometer with particle energy (on the cells) between 94-603 MeV/u. The X-chromosome linked hypoxanthine guanine phosphoribosyl transferase (hprt) locus was used as the target gene. Exposure to these high LET charged particles resulted in exponential survival curves; whereas, mutation induction was fitted by a linear model. The Relative Biological Effect (RBE) for cell-killing ranged from 3.73 to 1.25, while that for mutant induction ranged from 5.74 to 0.48. Maximum RBE values were obtained at the LET of 150 keV/micrometer. The inactivation cross-section (alpha i) and the action cross-section for mutant induction (alpha m) ranged from 2.2 to 92.0 micrometer2 and 0.09 to 5.56 x 10(-3) micrometer2, respectively. The maximum values were obtained by 56Fe with an LET of 200 keV/micrometer. The mutagenicity (alpha m/alpha i) ranged from 2.05 to 7.99 x 10(-5) with the maximum value at 150 keV/micrometer. Furthermore, molecular analysis of mutants induced by charged particles indicates that higher LET beams are more likely to cause larger deletions in the hprt locus.

  6. Survival and yields of chromosome aberrations in hamster and human lung cells irradiated by alpha particles

    SciTech Connect

    Simmons, J.A.; Cohn, P.; Min, T. [Univ. of Westminster, London (United Kingdom)

    1996-02-01

    The effects of {alpha}-particle irradiation on hamster and human lung cells have been studied. In both cases two end points were taken, cell death and the induction of chromosome aberrations. The hamster cells were common stock V79 cells; the human ones were freshly derived from fetal material. For both types of cells, the survival curves could be described by straight lines in the conventional exponential plot, with values of D{sub 0} of 0.78 and 0.37 Gy for the hamster and human cells, respectively. The rate of induction of chromosome aberrations could also be described by straight lines with slopes of 0.30 and 0.62 aberration per cell per gray. Thus, for this second end point also, it appears that human cells are twice as sensitive to the effects of {alpha}-particle irradiation as hamster cells. 30 refs., 3 figs., 2 tabs.

  7. Targeted alpha-particle radiotherapy with 211At-labeled monoclonal antibodies.

    PubMed

    Zalutsky, Michael R; Reardon, David A; Pozzi, Oscar R; Vaidyanathan, Ganesan; Bigner, Darell D

    2007-10-01

    An attractive feature of targeted radionuclide therapy is the ability to select radionuclides and targeting vehicles with characteristics that are best suited for a particular clinical application. One combination that has been receiving increasing attention is the use of monoclonal antibodies (mAbs) specifically reactive to receptors and antigens that are expressed in tumor cells to selectively deliver the alpha-particle-emitting radiohalogen astatine-211 (211At) to malignant cell populations. Promising results have been obtained in preclinical models with multiple 211At-labeled mAbs; however, translation of the concept to the clinic has been slow. Impediments to this process include limited radionuclide availability, the need for suitable radiochemistry methods operant at high activity levels and lack of data concerning the toxicity of alpha-particle emitters in humans. Nonetheless, two clinical trials have been initiated to date with 211At-labeled mAbs, and others are planned for the near future. PMID:17921029

  8. Cytotoxic reaction and TNF-alpha response of macrophages to polyurethane particles.

    PubMed

    Ma, Nan; Petit, Alain; Yahia, L'Hocine; Huk, Olga L; Tabrizian, Maryam

    2002-01-01

    Their unique mechanical and biological properties make polyurethanes (PUs) ideal materials for many implantable devices. However, uncertain long-term biostability in the human physiological environment limits their extensive clinical applications. Chronic inflammatory response associated with macrophage activation has been suggested as a prime factor; although the mechanism of macrophage activation in response to biomaterial surfaces and debris is still unknown. The overall objective of this work was to study the response of macrophages to PU materials in vitro by measuring cell viability and activity. The studies were carried out using phagocytozable-size PU particles from three types of commercially-available PUs: Pellethane 2363 80ABA (PL); Tecothane TT2065 (TC65); and Tecothane TT2085 (TC85). These polymers posess the same generic composition but differ in the length of hard and soft segments, as revealed by the FTIR and NMR studies. The results showed that PU particles affected both viability and activity of J774 macrophages. The percentage of mortality ranged from 1 to 15% with 10-100 microg ml(-1) of particles after 24 and 48 h incubation. These three types of particles induced different mortality on the macrophages. Specifically, the mortality with PL particles was 1-4% (p > 0.05), while the mortality with TC85 particles was 2-10% (p < 0.05) and 4-15% with TC65 (p < 0.05). Conversely, these particles also affected cell proliferation. Cell numbers increased by 132 and 167% after 24 and 48 h incubation, respectively, without particles, whereas the cell numbers increased only 46 and 78% with TC65, 66 and 105% with TC85, and 67 and 110% with PL in the presence of 100 microg ml(-1) of particles for the respective incubation times. PU particles also increased TNF-alpha release from macrophage. After having been incubated for 24 h with 100 microg ml(-1) particles of TC65, TC85, and PL, macrophages release TNF-alpha 7.4, 5.2, and 4.1 times more than the control. In conclusion, PU particles had cytotoxic effects on J774 macrophage at high concentrations. The order of macrophage response for three types of particles was TC65 > TC85 > PL. PU particles' effect on macrophage viability and activity depends on the concentration of particles and their chemical composition, especially on the ratio of hard to soft segments. PMID:12102593

  9. Determination of the range of alpha particles in histological samples using a proton beam

    Microsoft Academic Search

    M Giacomelli; J Skvar?; R Ili?

    2001-01-01

    The 70?m-thick sliced mouse samples used in boron neutron capture therapy research are normally freeze-dried and permanently mounted on a sticky tape. Such a preparation alters the tissue density and makes it impossible to correctly determine the ranges of the alpha particles from the 10B(n,?)7Li reaction. Proton radiography utilising etched-track detectors can be successfully used for the density determination of

  10. Choosing fitting functions to describe peak tails in alpha-particle spectrometry

    Microsoft Academic Search

    C. John Bland

    1998-01-01

    We seek to identify the major differences between two types of peak-fitting programs for alpha-particle spectrometry. One function is the well-known convolution of a Gaussian function with two (usually) left-handed exponential functions. The other function is contained in an analysis program described by Koskelo et al. (Koskelo, M. J., Burnett, W. C. and Cable, P. H. (1996) An advanced analysis

  11. Alpha-Particle-Driven Toroidal Alfvén Eigenmodes in the Tokamak Fusion Test Reactor

    Microsoft Academic Search

    R. Nazikian; G. Y. Fu; S. H. Batha; M. G. Bell; R. E. Bell; R. V. Budny; C. E. Bush; Z. Chang; Y. Chen; C. Z. Cheng; D. S. Darrow; P. C. Efthimion; E. D. Fredrickson; N. N. Gorelenkov; B. Leblanc; F. M. Levinton; R. Majeski; E. Mazzucato; S. S. Medley; H. K. Park; M. P. Petrov; D. A. Spong; J. D. Strachan; E. J. Synakowski; G. Taylor; S. von Goeler; R. B. White; K. L. Wong; S. J. Zweben

    1997-01-01

    Alpha-particle-driven toroidal Alfvén eigenmodes (TAEs) have been observed for the first time in deuterium-tritium (D-T) plasmas on the tokamak fusion test reactor (TFTR). These modes are observed 100-200 ms following the end of neutral beam injection in plasmas with reduced central magnetic shear and elevated central safety factor [q0>1]. Mode activity is localized to the central region of the discharge

  12. GaN as a detector of alpha-particles and neutrons

    Microsoft Academic Search

    A. Y. Polyakov; N. B. Smirnov; A. V. Govorkov; In-Hwan Lee; S. J. Pearton; N. G. Kolin; I. L. Gazizov; V. M. Zalyetin

    2011-01-01

    Properties of GaN radiation detectors are analyzed. It is shown that present day epitaxial material is suitable for detection of alpha-particles with the charge collection efficiency close to 100%. Such detectors can operate at temperatures of at least 60°C and withstand irradiation with reactor neutrons fluences higher than 1015 cm-2. They keep the collection efficiency at 30% even after irradiation

  13. Study of the beta-delayed alpha-particle emission of [sup 16]N

    Microsoft Academic Search

    Z. Zhao; R. H. France; K. S. Lai; M. Gai; E. L. Wilds; R. A. Kryger; J. A. Winger; K. B. Beard

    1993-01-01

    The beta-delayed alpha-particle emission of [sup 16]N has been studied, with [sup 16]N nuclei produced using 80 MeV\\/nucleon [sup 18]O beams on [sup 9]Be targets. The [sup 16]N secondary nuclei were mass analyzed and separated from the reaction products using the Michigan State University A1200 isotope separator. A detector array, including four thin surface barrier detectors, a [ital p]-[ital i]-[ital

  14. Study of the beta-delayed alpha-particle emission of 16N

    Microsoft Academic Search

    Z. Zhao; R. H. France III; K. S. Lai; M. Gai; E. L. Wilds; R. A. Kryger; J. A. Winger; K. B. Beard

    1993-01-01

    The beta-delayed alpha-particle emission of 16N has been studied, with 16N nuclei produced using 80 MeV\\/nucleon 18O beams on 9Be targets. The 16N secondary nuclei were mass analyzed and separated from the reaction products using the Michigan State University A1200 isotope separator. A detector array, including four thin surface barrier detectors, a p-i-n diode, a Ge gamma-ray detector, and a

  15. Fusion alpha-particle losses in a high-beta rippled tokamak

    SciTech Connect

    Bunno, M.; Nakamura, Y. [Graduate School of Energy Science, Kyoto University, Gokasho, Uji, Kyoto 611-0011 (Japan)] [Graduate School of Energy Science, Kyoto University, Gokasho, Uji, Kyoto 611-0011 (Japan); Suzuki, Y. [National Institute for Fusion Science, Toki 509-5292 (Japan)] [National Institute for Fusion Science, Toki 509-5292 (Japan); Shinohara, K.; Matsunaga, G. [Japan Atomic Energy Agency, Naka, Ibaraki 311-0193 (Japan)] [Japan Atomic Energy Agency, Naka, Ibaraki 311-0193 (Japan); Tani, K. [Nippon Advanced Technology, Naka, Ibaraki 311-0102 (Japan)] [Nippon Advanced Technology, Naka, Ibaraki 311-0102 (Japan)

    2013-08-15

    In tokamak plasmas, the confinement of energetic ions depends on the magnetic field structure. If the plasma pressure is finite, the equilibrium current (i.e., the Pfirsch-Schlüter current and diamagnetic current) flows in the plasma to maintain the magnetohydrodynamic (MHD) equilibrium. These plasma currents generate poloidal and toroidal magnetic field and alter the field structure. Moreover, if we consider the non-axisymmetry of magnetic field structures such as toroidal field (TF) ripples, the non-axisymmetric component of the equilibrium current can alter TF ripples themselves. When the plasma beta becomes high, the changes in the field structure due to the equilibrium current might affect the confinement of energetic ions significantly. We intend to clarify how these currents alter the field structure and affect the confinement of alpha particles in high-beta plasma. The MHD equilibrium is calculated using VMEC and the orbits of fusion alpha particles are followed by using the fully three-dimensional magnetic field orbit-following Monte Carlo code. In relatively low-beta plasma (e.g., the volume-averaged beta value ?2%), the changes in the magnetic field component due to the plasma current negligibly affect the confinement of alpha particles except for the Shafranov shift effect. However, for ?3%, the diamagnetic effect reduces the magnetic field strength and significantly increases alpha-particle losses. In these high-beta cases, the non-axisymmetric field component generated by the equilibrium current also increases these losses, but not as effectively as compared to the diamagnetic effect.

  16. Accuracy testing using thick source alpha-particle spectroscopy for the U and Th series estimations.

    PubMed

    Michael, C T; Zacharias, N; Hein, A

    2010-01-01

    The new technique for the calculation of U and Th based on the alpha particle spectrum taken from a thick sample by using a silicon detector (PIPS) is tested and some technical problems are encountered and also some notifications for better accuracy are addressed. This technique which is mainly developed to be used for dose rate determination in TL, OSL and ESR dating applications, gives also the possibility for detecting and estimating possible disequilibrium in U and Th series. PMID:19900816

  17. Wurtzite Gallium Nitride as a scintillator detector for alpha particles (a Geant4 simulation)

    NASA Astrophysics Data System (ADS)

    Taheri, A.; Sheidaiy, M.

    2015-05-01

    Gallium Nitride has become a very popular material in electronics and optoelectronics. Because of its interesting properties, it is suitable for a large range of applications. This material also shows very good scintillation properties that make it a possible candidate for use as a charged particles scintillator detector. In this work, we simulated the scintillation and optical properties of the gallium nitride in the presence of alpha particles using Geant4. The results show that gallium nitride can be an appropriate choice for this purpose.

  18. Hormetic effect induced by alpha-particle-induced stress communicated in vivo between zebrafish embryos.

    PubMed

    Choi, V W Y; Cheung, A L Y; Cheng, S H; Yu, K N

    2012-11-01

    We report data showing that embryos of the zebrafish, Danio rerio, at 1.5 h post fertilization (hpf) subjected to a low-dose alpha-particle irradiation can release a stress signal into the water, which can be communicated to unirradiated bystander zebrafish embryos sharing the same water medium to induce a hormetic effect in the bystander embryos. Hormetic responses are characterized as biphasic dose-response relationships exhibiting a low-dose stimulation and a high-dose inhibition. The effects on the whole embryos were studied through quantification of apoptotic signals at 24 hpf through staining with the vital dye acridine orange, followed by counting the stained cells under a microscope. The results show that, for low alpha-particle dose, the number of apoptotic signals decreases in the irradiated embryos and also in the unirradiated bystander embryos having partnered with the irradiated embryos. These suggested that alpha-particle-irradiated zebrafish embryos could release a stress signal into the water, which could be communicated to unirradiated bystander zebrafish embryos sharing the same water medium to induce a hormetic effect in the bystander embryos. PMID:23050846

  19. Electrostatic ion-acoustic-like instabilities in the solar wind with a backstreaming alpha particle beam

    SciTech Connect

    Gomberoff, L. [Departamento de Fisica, Facultad de Ciencias, Universidad de Chile, Santiago (Chile); Gomberoff, K. [Department of Physics, Technion, Haifa 32000 (Israel); Deutsch, A. [Rafael, P.O. Box 2250, Haifa 31021 (Israel)

    2010-06-15

    Nonlinear electrostatic instabilities have been shown to occur frequently and under very different conditions in plasma with two ion beams such as the fast solar wind. These instabilities can be triggered when the phase velocity of electrostatic ion-acoustic waves propagating forward and backward relative to the interplanetary magnetic field overlaps due to the presence of a finite amplitude of circularly polarized wave. The instabilities can be triggered by waves supported by the same ion component, or by waves supported by different ion components. By assuming a beam of alpha particles moving backward relative to the external magnetic field, as observed in some events in the fast solar wind, it is shown that a very small negative drift velocity of the alpha particle beam relative to the core plasma--a few percent of the local Alfven velocity--can trigger a very rich variety of nonlinear electrostatic acousticlike instabilities. Their growth rates can be rather large and they persist for larger negative alpha particles drift velocities and temperatures.

  20. Coinhibition of viral interferon induction by Benzo(. alpha. )pyrene in association with occupation-related particles

    SciTech Connect

    Hahon, N. (National Inst. for Occupational Safety and Health, Morgantown, WV (United States) West Virginia Univ., Morgantown (United States)); Booth, J.A. (West Virginia Univ., Morgantown (United States)); Flowers, L. (Univ. of Pennsylvania, Philadelphia (United States))

    1990-06-01

    Benzo({alpha})pyrene (B(a)P) in combination with coal, asbestos, silicate, or metal particles was studied for its inhibitory effects on interferon-{alpha}/{beta} induction by influenza virus in rhesus monkey kidney (LLC-MK{sub 2}) cell monolayers. B(a)P per se had no adverse effect on the induction process. However, when cell cultures were pretreated with B(a)P that was bioactivated by rat liver S9 homogenate, from 52 to 65% inhibition of interferon induction occurred. Significantly greater depression (coinhibition) of viral interferon induction (>83%) resulted when bioactivated B(a)P was incorporated with coal particles representative of coal rank (anthracite, bituminous, lignite, peat). Coinhibition affected by bioactivated B(a)P was coal rank-independent but any interferon inhibitory activity affected by coal particles per se was coal rank-independent. When metals (aluminum, aluminum oxide, ferric oxide, nickel, or chromium) or asbestos fibers were individually mixed with bioactivated B(a)P, coinhibition of cellular interferon synthesis also resulted which was significantly greater than that manifested by bioactivated B(a)P or particles per se. Coinhibition of interferon induction by silicates and the bioactivated hydrocarbon was not in evidence although some silicates alone partially inhibited the induction process. Viral interferon induction was inhibited in a dose-response manner by B(a)P ({+-}S9) in combination with selected particles.

  1. Preferential energization of alpha particles in polar coronal holes at one solar radius above the photosphere

    NASA Astrophysics Data System (ADS)

    Chakravarty, Aniruddha; Bose, M.

    2015-04-01

    Heating of polar coronal holes (PCH) during solar minimum and acceleration of the fast solar wind issuing therefrom lack comprehensive theoretical understanding. Wave-particle interactions are considered to have crucial effects on the extreme properties of heavy ions in the collisionless region of the PCH. In this paper, we have presented a novel sensitivity analysis to investigate plasma heating by radio waves at lower hybrid (LH) frequencies. We have employed a three-fluid Maxwell model comprising electrons, protons, and ?-particles at around two solar radii heliocentric distance in the PCH and derived a dispersion relation as a 13th-order polynomial for the frequency. Our model provides indications of preferential heating of ?-particles in comparison with protons by means of LH instabilities. We have employed the electron velocity and spatial charge distribution as our basic study tools so as to show the effects of alpha-proton differential mass and differential perpendicular velocity on the preferential heating of ?-particles.

  2. The calibration of photographic and spectroscopic films: The response of 2aO film to small dosages of alpha particles from 3/10th's rad to 8 rads at energy levels 153 MeV, 79 MeV and 47 MeV

    NASA Technical Reports Server (NTRS)

    Hammond, E. C., Jr.; Peters, Kevin; Stober, AL

    1984-01-01

    The 2aO film, pre-exposed to a series of neutral density filters which on development under standard conditions will produce the standard H-D curve for that film, were then exposed to Alpha paricles with a dose range of 3/10ths rads to 8 rads while varying the energy of the particles using 153 MeV, 70 MeV, and 47 MeV, respectively. An analysis of the film shows that the 3/10th rad dose produces the lowest optical density changes at 70 MeV and 47 MeV. While the optical density readings for the darker patterns seem to oscillate and decrease when exposed to radiation dosages of 3/10th rads to 8 rads.

  3. Ab initio alpha-alpha scattering

    E-print Network

    Serdar Elhatisari; Dean Lee; Gautam Rupak; Evgeny Epelbaum; Hermann Krebs; Timo A. Lähde; Thomas Luu; Ulf-G. Meißner

    2015-06-11

    Processes involving alpha particles and alpha-like nuclei comprise a major part of stellar nucleosynthesis and hypothesized mechanisms for thermonuclear supernovae. In an effort towards understanding alpha processes from first principles, we describe in this letter the first ab initio calculation of alpha-alpha scattering. We use lattice effective field theory to describe the low-energy interactions of nucleons and apply a technique called the adiabatic projection method to reduce the eight-body system to an effective two-cluster system. We find good agreement between lattice results and experimental phase shifts for S-wave and D-wave scattering. The computational scaling with particle number suggests that alpha processes involving heavier nuclei are also within reach in the near future.

  4. Ab initio alpha-alpha scattering

    E-print Network

    Elhatisari, Serdar; Rupak, Gautam; Epelbaum, Evgeny; Krebs, Hermann; Lähde, Timo A; Luu, Thomas; Meißner, Ulf-G

    2015-01-01

    Processes involving alpha particles and alpha-like nuclei comprise a major part of stellar nucleosynthesis and hypothesized mechanisms for thermonuclear supernovae. In an effort towards understanding alpha processes from first principles, we describe in this letter the first ab initio calculation of alpha-alpha scattering. We use lattice effective field theory to describe the low-energy interactions of nucleons and apply a technique called the adiabatic projection method to reduce the eight-body system to an effective two-cluster system. We find good agreement between lattice results and experimental phase shifts for S-wave and D-wave scattering. The computational scaling with particle number suggests that alpha processes involving heavier nuclei are also within reach in the near future.

  5. Radioimmunotherapy of Breast Cancer Metastases with Alpha-Particle-emitter 225Ac: Comparing Efficacy with 213Bi, 90Y

    PubMed Central

    Song, Hong; Hobbs, Robert F.; Vajravelu, Ravy; Huso, David L.; Esaias, Caroline; Apostolidis, Christos; Morgenstern, Alfred; Sgouros, George

    2009-01-01

    Alpha-particles are suitable to treat cancer micrometastases because of their short range and very high linear energy transfer. Alpha-particle-emitter 213Bi based radioimmunotherapy has shown efficacy in a variety of metastatic animal cancer models, such as breast, ovarian, prostate cancer and leukemia. Its clinical implementation, however, is challenging due to the limited supply of 225Ac, the high technical requirement to prepare radioimmunoconjugate with very short half-life (T1/2=45.6 mins) on site and prohibitive cost. In this study, we investigated the efficacy of the alpha-particle-emitter 225Ac, parent of 213Bi, in a mouse model of breast cancer metastases. A single administration of 225Ac (400 nCi) labeled anti-rat HER-2/neu monoclonal antibody (7.16.4) completely eradicated breast cancer lung micrometastases in about 67% of HER-2/neu transgenic mice and led to long-term survival of these mice for up to one year. Treatment with 225Ac-7.16.4 is significantly more effective than 213Bi-7.16.4 (120 ?Ci) (median survival = 61 days, P=0.001), and 90Y-7.16.4 (120 ?Ci) (median survival = 50 days, P<0.001), as well as untreated control (median survival = 41 days, P=0.0001). Dosimetric analysis showed that 225Ac treated metastases received a total dose of 9.6 Gy, significantly higher than 2.0 Gy from 213Bi and 2.4 Gy from 90Y. Biodistribution studies revealed that 225Ac daughters, 221Fr and 213Bi, accumulated in kidneys and probably contributed to the long-term renal toxicity observed in surviving mice. These data suggest 225Ac labeled anti-HER-2/neu monoclonal antibody could significantly prolong survival in HER-2/neu-positive metastatic breast cancer patients. PMID:19920193

  6. Radioimmunotherapy of breast cancer metastases with alpha-particle emitter 225Ac: comparing efficacy with 213Bi and 90Y.

    PubMed

    Song, Hong; Hobbs, Robert F; Vajravelu, Ravy; Huso, David L; Esaias, Caroline; Apostolidis, Christos; Morgenstern, Alfred; Sgouros, George

    2009-12-01

    alpha-Particles are suitable to treat cancer micrometastases because of their short range and very high linear energy transfer. alpha-Particle emitter (213)Bi-based radioimmunotherapy has shown efficacy in a variety of metastatic animal cancer models, such as breast, ovarian, and prostate cancers. Its clinical implementation, however, is challenging due to the limited supply of (225)Ac, high technical requirement to prepare radioimmunoconjugate with very short half-life (T(1/2) = 45.6 min) on site, and prohibitive cost. In this study, we investigated the efficacy of the alpha-particle emitter (225)Ac, parent of (213)Bi, in a mouse model of breast cancer metastases. A single administration of (225)Ac (400 nCi)-labeled anti-rat HER-2/neu monoclonal antibody (7.16.4) completely eradicated breast cancer lung micrometastases in approximately 67% of HER-2/neu transgenic mice and led to long-term survival of these mice for up to 1 year. Treatment with (225)Ac-7.16.4 is significantly more effective than (213)Bi-7.16.4 (120 microCi; median survival, 61 days; P = 0.001) and (90)Y-7.16.4 (120 microCi; median survival, 50 days; P < 0.001) as well as untreated control (median survival, 41 days; P < 0.0001). Dosimetric analysis showed that (225)Ac-treated metastases received a total dose of 9.6 Gy, significantly higher than 2.0 Gy from (213)Bi and 2.4 Gy from (90)Y. Biodistribution studies revealed that (225)Ac daughters, (221)Fr and (213)Bi, accumulated in kidneys and probably contributed to the long-term renal toxicity observed in surviving mice. These data suggest (225)Ac-labeled anti-HER-2/neu monoclonal antibody could significantly prolong survival in HER-2/neu-positive metastatic breast cancer patients. PMID:19920193

  7. Very High Efficiency, Miniaturized, Long-Lived Alpha Particle Power Source Using Diamond Devices for Extreme Space Environments

    NASA Technical Reports Server (NTRS)

    Kolawa, Elizabeth A. (Inventor); Patel, Jagdishbhai U. (Inventor); Fleurial, Jean-Pierre (Inventor)

    2004-01-01

    A power source that converts a-particle energy into electricity by coulomb collision in doped diamond films is described. Alpha particle decay from curium-244 creates electron-hole pairs by free- ing electrons and holes inside the crystal lattice in N- and P-doped diamond films. Ohmic contacts provide electrical connection to an electronic device. Due to the built-in electric field at the rectifying junction across the hT- and P-doped diamond films, the free electrons are constrained to traveling in generally one direction. This one direction then supplies electrons in a manner similar to that of a battery. The radioactive curium layer may be disposed on diamond films for even distribution of a-particle radiation. The resulting power source may be mounted on a diamond substrate that serves to insulate structures below the diamond substrate from a-particle emission. Additional insulation or isolation may be provided in order to prevent damage from a-particle collision. N-doped silicon may be used instead of N-doped diamond.

  8. Exciton dynamics in alpha-particle tracks in organic crystals: Magnetic field study of the scintillation in tetracene crystals

    Microsoft Academic Search

    Nicholas E. Geacintov; Michael Binder; Charles E. Swenberg; Martin Pope

    1975-01-01

    The mechanisms of scintillation of organic crystals bombarded by alpha particles are discussed in terms of the current knowledge of exciton dynamics, which has been derived from a study of the photofluorescence of crystals such as anthracene and tetracene. The scintillation of tetracene excited by 4.4-MeV alpha particles incident in a direction perpendicular to the ab plane has been studied

  9. Deep level defects and carrier removal due to proton and alpha particle irradiation of InP

    Microsoft Academic Search

    George C. Rybicki; Christian A. Zorman

    1994-01-01

    Deep level transient spectroscopy and capacitance voltage measurements of the defect introduction rates and carrier removal rates for 2 MeV proton and 2 MeV alpha particle irradiations in p-type InP have been performed. The carrier removal rate for 2 MeV protons was 6500 cm?1 and for 2 MeV alpha particles was 73 400 cm?1, or 12 times higher. The defect

  10. An analysis of 25Al energy levels observed in the 28Si(p,alpha)25Al reaction

    SciTech Connect

    Pittman, S. T. [University of Tennessee, Knoxville (UTK); Bardayan, Daniel W [ORNL; Blackmon, Jeff C [ORNL; Kozub, R. L. [Tennessee Technological University; Smith, Michael Scott [ORNL

    2009-01-01

    The level structure of {sup 25}Al has been studied at the ORNL Holifield Radioactive Ion Beam Facility (HRIBF) by measuring the angular and energy distributions of alpha particles from the {sup 28}Si(p,{alpha}){sup 25}Al reaction. Proton beams ({approx}10 nA) at laboratory energies of 40- and 42-MeV were generated by the 25 MV tandem accelerator and bombarded a natural silicon target (50 {micro}g/cm{sup 2}). Alpha particles were detected and identified in the Silicon Detector Array (SIDAR) in the 'telescope' configuration [1]. Eighteen levels have been observed and spins for several have been constrained through a distorted-wave Born approximation (DWBA) analysis of the angular distributions.

  11. Cytogenetic and molecular genetic analysis of tumorigenic human bronchial epithelial cells induced by radon alpha particles.

    PubMed

    Weaver, D A; Hei, T K; Hukku, B; McRaven, J A; Willey, J C

    1997-06-01

    To establish a cell culture model for lung carcinogenesis, independent populations of the human papillomavirus 18-immortalized human bronchial epithelial cell line BEP2D were treated with high linear energy transfer radon-simulated alpha-particles, expanded and xenotransplanted into Nu/Nu mice. Six independent cell lines were established from tumors that developed from three separate radiation treatments as follows: treatment (Tx) 1 (30 cGy--two doses), H2BT, Tx 2 (30 cGy--single dose), R30T1L, R30T2 and R30T3L, Tx 3 (30 cGy--single dose), H1ATN and H1ATBA1. Cytogenetic analysis revealed common changes in all tumor lines: loss of the Y chromosome (ch), one of three copies of ch8, one of three copies of ch14, and one of two copies of ch4p16-pter and ch11p15-pter. Analysis of polymerase chain reaction-amplified short tandem repeats of informative loci confirmed the loss of chY in all lines and loss of heterozygosity (LOH) at eight loci spanning the length of ch8 in all lines from Tx's 1 and 2. Our data support previous studies indicating the presence of tumor suppressor genes on ch8. LOH also was confirmed on ch14 at locus D14S306 in all cell lines from Tx 2 and in one of two lines from Tx 3. This region, 14q12-q13, may contain changes in one of the five known somatostatin receptor genes (SSTR1). No LOH was detected at any of the informative loci tested for on ch4 or ch11. PMID:9214610

  12. High resolution alpha particle detection using 4H-SiC epitaxial layers: Fabrication, characterization, and noise analysis

    NASA Astrophysics Data System (ADS)

    Chaudhuri, Sandeep K.; Zavalla, Kelvin J.; Mandal, Krishna C.

    2013-11-01

    In this article we report the fabrication and characterization of large area, room-temperature operable and very high resolution Schottky barrier detectors for alpha particles using 20 ?m thick n-type 4H-SiC epitaxial layers. Schottky barriers were fabricated by depositing circular nickel contacts of ~11 mm2 area on the 4H-SiC epitaxial layers. Room temperature current-voltage measurements revealed very high Schottky barrier height of 1.6 eV and extremely low leakage current of 3.5 pA at an operating reverse bias of -90 V. We also report an energy resolution of 0.29%, which is the best resolution obtained so far for uncollimated 5.48 MeV alpha particles in 4H-SiC epitaxial detectors with such a large area. Very low micropipe density (<1 cm-2) and low effective doping concentration (2.4×1014 cm-3) in the epilayer helped to achieve a high resolution even with the large detector area and a broad source. A diffusion length of ~18.6 ?m for holes has been determined in these detectors following a calculation based on a drift-diffusion model. A noise analysis in terms of equivalent noise charge revealed that the white series noise due to the detector capacitance has substantial effect on their spectroscopic performance.

  13. Orbit-averaged drift kinetic equation for the study of alpha-particle transport in tokamaks

    SciTech Connect

    Sager, G.T.; Miley, G.H. (Illinois Univ., Urbana, IL (United States). Fusion Studies Lab.); Burrell, K.H. (General Atomics Co., San Diego, CA (United States))

    1990-11-01

    Neoclassical transport of minority suprathermal alpha particles is investigated. This paper departs from previous investigations in that (a) the banana-width ordering parameter {rho}{sub {theta}}/L is not formally restricted to be a small parameter and (b) a linearized collision operator that retains the effects of pitch-angle scattering, electron and ion drag, and speed diffusion is used. A step model approximation for the large-aspect-ratio, circular-cross-section tokamak magnetic field is adopted to simplify the orbit-averaging procedure. Assuming that the suprathermal alphas are in the banana regime, an asymptotic expansion in {tau}{sub B}/{tau}{sub S} {much lt} l is carried out.

  14. Secondary electron yields from the bombardment of Al 2O 3 by protons, deuterons, alpha-particles and positively charged hydrogen molecules at energies in the range of 10 to 80 MeV

    Microsoft Academic Search

    C. M. Castaneda; L. McGarry; C. Cahill; T. Essert

    1997-01-01

    Measurements of the electron coefficients of Al2O3 surfaces bombarded by protons, deuterons, alphas and single ionized hydrogen molecules are presented. The 76?-cyclotron of the Crocker Nuclear Laboratory of the University of California was used to accelerate those ions in the range of 10 to 80 MeV. The data has been compared to theoretical predictions and to previous experimental work. For

  15. Investigations of factors affecting the use of uranium metal as a source of alpha particles for the evaluation of alpha track detectors

    E-print Network

    Voirin, Marc

    1994-01-01

    , an uranium foil was used as the alpha particle source. The foil created new problems which needed to be studied in detail. Among these problems, the effect of the thickness of the oxide layer on the uranium metal foil surface was the most important. To study...

  16. Investigations of factors affecting the use of uranium metal as a source of alpha particles for the evaluation of alpha track detectors 

    E-print Network

    Voirin, Marc

    1994-01-01

    , an uranium foil was used as the alpha particle source. The foil created new problems which needed to be studied in detail. Among these problems, the effect of the thickness of the oxide layer on the uranium metal foil surface was the most important. To study...

  17. Energy and electron transfer in alpha-zirconium phosphate/poly(allylamine hydrochloride) thin films

    NASA Astrophysics Data System (ADS)

    Kaschak, David M.

    The intercalation and exfoliation reactions of alpha-zirconium phosphate, Zr(HPO4)2.H2O (alpha-ZrP), were studied microscopically by atomic force microscopy (AFM) and transmission electron microscopy (TEM). The reaction of alpha-ZrP with tetra( n-butylammonium) hydroxide (TBA+OH-) initially produces intercalation compounds, which then separate into unilamellar colloids. A hydrolysis reaction of alpha-ZrP colloids proceeds from the edges inwards, forming ˜4 nm zirconia particles that decorate the edges of the sheets. The hydrolysis reaction is negligible at 0°C, which permits the synthesis of hydrolysis-free unilamellar colloids. These colloids form monolayer films on amine-derivatized silicon surfaces with a high density that suggests significant surface mobility during the adsorption process. Multilayer organic/inorganic thin films containing fluorescent probe molecules were assembled on planar glass substrates by sequentially adsorbing monolayers of poly(allylamine hydrochloride) derivatized with fluorescein or rhodamine B, and exfoliated alpha-ZrP. Different donor-acceptor geometries were prepared by changing the placement and number of alpha-ZrP and PAH layers separating the fluorescein/PAH and rhodamineB/PAH layers. A Monte Carlo simulation of the Forster energy transfer process in each geometry was compared with the energy transfer efficiency determined from steady-state luminescence spectra. Near-field scanning optical microscopy was used to obtain localized measurements of the energy transfer from RhB-PAH to Texas Red derivatized PAH (TR-PAH). The construction of more complex systems, which perform multi-step energy/electron transfer reactions, is described. By using three complementary chromophores, excitation is collected from a substantial fraction of the visible spectrum and funneled to a trap molecule that forms a long-lived triplet excited state. This trap molecule then transfers an electron to an acceptor in the next layer. The charge separation quantum efficiency and lifetime can be significantly increased by replacing alpha-ZrP with the active spacer HTiNbO5, an oxide semiconductor. In this case, there is a five-component energy/electron transfer cascade in which there are no covalent bonds between any of the photo- or redox-active components.

  18. Chemistry of Rocks and Soils in Gusev Crater from the Alpha Particle X-ray Spectrometer

    NASA Technical Reports Server (NTRS)

    Gellert, R.; Rieder, R.; Anderson, R. C.; Brueckner, J.; Clark, B. C.; Dreibus, G.; Economou, T.; Klingelhoefer, G.; Lugmair, G. W.; Ming, D. W.

    2005-01-01

    The alpha particle x-ray spectrometer on the Spirit rover determined major and minor elements of soils and rocks in Gusev crater in order to unravel the crustal evolution of planet Mars. The composition of soils is similar to those at previous landing sites, as a result of global mixing and distribution by dust storms. Rocks (fresh surfaces exposed by the rock abrasion tool) resemble volcanic rocks of primitive basaltic composition with low intrinsic potassium contents. High abundance of bromine (up to 170 parts per million) in rocks may indicate the alteration of surfaces formed during a past period of aqueous activity in Gusev crater.

  19. Chemistry of rocks and soils in Gusev Crater from the alpha particle x-ray spectrometer.

    PubMed

    Gellert, R; Rieder, R; Anderson, R C; Brückner, J; Clark, B C; Dreibus, G; Economou, T; Klingelhöfer, G; Lugmair, G W; Ming, D W; Squyres, S W; D'Uston, C; Wänke, H; Yen, A; Zipfel, J

    2004-08-01

    The alpha particle x-ray spectrometer on the Spirit rover determined major and minor elements of soils and rocks in Gusev crater in order to unravel the crustal evolution of planet Mars. The composition of soils is similar to those at previous landing sites, as a result of global mixing and distribution by dust storms. Rocks (fresh surfaces exposed by the rock abrasion tool) resemble volcanic rocks of primitive basaltic composition with low intrinsic potassium contents. High abundance of bromine (up to 170 parts per million) in rocks may indicate the alteration of surfaces formed during a past period of aqueous activity in Gusev crater. PMID:15297665

  20. Chemistry of rocks and soils at Meridiani Planum from the Alpha Particle X-ray Spectrometer.

    PubMed

    Rieder, R; Gellert, R; Anderson, R C; Brückner, J; Clark, B C; Dreibus, G; Economou, T; Klingelhöfer, G; Lugmair, G W; Ming, D W; Squyres, S W; d'Uston, C; Wänke, H; Yen, A; Zipfel, J

    2004-12-01

    The Alpha Particle X-ray Spectrometer on the Opportunity rover determined major and minor elements of soils and rocks in Meridiani Planum. Chemical compositions differentiate between basaltic rocks, evaporite-rich rocks, basaltic soils, and hematite-rich soils. Although soils are compositionally similar to those at previous landing sites, differences in iron and some minor element concentrations signify the addition of local components. Rocky outcrops are rich in sulfur and variably enriched in bromine relative to chlorine. The interaction with water in the past is indicated by the chemical features in rocks and soils at this site. PMID:15576611

  1. Mapping alpha-Particle X-Ray Fluorescence Spectrometer (Map-X)

    NASA Technical Reports Server (NTRS)

    Blake, D. F.; Sarrazin, P.; Bristow, T.

    2014-01-01

    Many planetary surface processes (like physical and chemical weathering, water activity, diagenesis, low-temperature or impact metamorphism, and biogenic activity) leave traces of their actions as features in the size range 10s to 100s of micron. The Mapping alpha-particle X-ray Spectrometer ("Map-X") is intended to provide chemical imaging at 2 orders of magnitude higher spatial resolution than previously flown instruments, yielding elemental chemistry at or below the scale length where many relict physical, chemical, and biological features can be imaged and interpreted in ancient rocks.

  2. Effects of pre-equilibrium nucleon emission on excitation functions of various reactions in vanadium induced by alpha particles

    Microsoft Academic Search

    N L Singh; S Mukherjee; A V Mohan Rao; L Chaturvedi; P P Singh

    1995-01-01

    Excitation functions for the 51V(( alpha ,n), ( alpha ,3n), ( alpha ,p3n), ( alpha ,p6n), ( alpha , alpha 3n), ( alpha , alpha 2pn), ( alpha ,2 alpha ), ( alpha ,2 alpha n) and ( alpha ,2 alpha 3n)) reactions have been measured up to 120 MeV using the stacked foil technique with a view to improving

  3. Optical-Model Analysis of Alpha-Particle Scattering by 36Ar from 12.83 to 17.83 MeV

    Microsoft Academic Search

    W. J. Wallace; K. R. Knuth; R. H. Davis

    1970-01-01

    Forty-six-point angular distributions for the elastic scattering of alpha particles by 36Ar have been measured with a gas target from 12.83 to 17.83 MeV in 20-keV intervals throughout the angular range from 29.0 to 167.8° (c.m.). Optical-model fits to the data smoothed in energy with a Lorentzian weighting function have been obtained. The computed cross sections were obtained from an

  4. Alfven waves, alpha particles, and pickup ions in the solar wind

    NASA Technical Reports Server (NTRS)

    Goldstein, B. E.; Neugebauer, M.; Smith, E. J.

    1995-01-01

    Past studies of the properties of Alfven waves in the solar wind have indicated that (1) the amplitude of the velocity fluctuations is almost always smaller than expected on the basis of the amplitude of the field fluctuations, even when the anisotropy of the plasma is taken into account, and (2) the alpha particles do not participate in the wave motions because they 'surf' on the waves carried by the proton fluid. Ulysses data are used to demonstrate that (1) the discrepancy between the velocity and field fluctuations is greater at high heliographic latitudes than in the ecliptic plane, and (2) the alphas do participate in the waves, being either in phase or out of phase with the proton motions depending on whether the differential flow speed between the alphas and protons is greater than or less than the 'observed' wave speed, B(sub o)(delta v squared / delta B squared)exp 1/2, as determined from the ratio of the amplitudes of the velocity and magnetic fluctuations. It is proposed that the modification of Alfven wave propagation speed is due to pressure anisotropies resulting from asymmetric distributions of interstellar pickup ions. If the proposed explanation is correct, it indicates that scattering of pickup ions onto a (bi)spherical shell may not be as complete as generally supposed.

  5. Alpha particle beam interactions with Fe-based FeCo-based amorphous magnets

    SciTech Connect

    Sorescu, M. [Duquesne Univ., Pittsburgh, PA (United States). Physics Dept.; Barb, D. [Inst. of Atomic Physics, Bucharest-Magurele (Romania)

    1997-12-01

    Samples of Fe{sub 78}B{sub 13}Si{sub 9} and Fe{sub 66}Co{sub 18}B{sub 15}Si{sub 1} metallic glasses were irradiated with alpha particle beams (W = 2.8 MeV) using radiation doses of 10{sup 16} and 10{sup 17} cm{sup {minus}2}. Irradiation-induced effects on the magnetic and structural properties of alloy samples were studied by transmission and conversion electron Moessbauer spectroscopy. The evolution of phases and microstructure during the radiation-induced amorphous-to-crystalline transformation was found to depend on the particle flux and sample composition. Differences between bulk and surface irradiation behaviors were demonstrated.

  6. High-resolution microcalorimeter energy-dispersive spectrometer for x-ray microanalysis and particle analysis

    SciTech Connect

    Wollman, D. A.; Hilton, G. C.; Irwin, K. D.; Dulcie, L. L.; Bergren, N. F.; Martinis, John M. [National Institute of Standards and Technology (NIST), Boulder, Colorado 80303 (United States); Newbury, Dale E. [National Institute of Standards and Technology (NIST), Gaithersburg, Maryland 20899 (United States); Woo, Keung-Shan; Liu, Benjamin Y. H. [University of Minnesota, Minneapolis, Minnesota 55455 (United States); Diebold, Alain C. [SEMATECH, 2706 Montopolis Drive, Austin, Texas 78731 (United States)

    1998-11-24

    We have developed a high-resolution microcalorimeter energy-dispersive spectrometer (EDS) at NIST that provides improved x-ray microanalysis of contaminant particles and defects important to the semiconductor industry. Using our microcalorimeter EDS mounted on a scanning electron microscope (SEM), we have analyzed a variety of specific sized particles on Si wafers, including 0.3 {mu}m diameter W particles and 0.1 {mu}m diameter Al{sub 2}O{sub 3} particles. To compare the particle analysis capabilities of microcalorimeter EDS to that of semiconductor EDS and Auger electron spectroscopy (AES), we report measurements of the Al-K{alpha}/Si-K{alpha} x-ray peak intensity ratio for 0.3 {mu}m diameter Al{sub 2}O{sub 3} particles on Si as a function of electron beam energy. We also demonstrate the capability of microcalorimeter EDS for chemical shift measurements.

  7. Observation of lunar radon emanation with the Apollo 15 alpha particle spectrometer.

    NASA Technical Reports Server (NTRS)

    Gorenstein, P.; Bjorkholm, P.

    1972-01-01

    The alpha particle spectrometer, a component of the orbital Sim Bay group of 'geochemistry' experiments on Apollo 15, was designed to detect alpha particles emitted during the decay of isotopes of radon gas and her daughter products. The purpose was to measure the gross activity of radon on the lunar surface and to find possible regions of increased local activity. Results are presented from a partial analysis of Apollo 15 data. For the moon as a whole, Rn220 was not observed and the upper limit on its decay rate above the lunar surface is 0.00038 disintegrations/sq cm-sec. Rn222 was marginally observed. Possible variations of radon activity on the lunar surface are being investigated. Po210 (a daughter product of Rn222) has been detected in a broad region from west of Mare Crisium to the Van de Graaff-Orlov region. The observed count rate is (4.6 plus or minus 1.4) x 0.001 disintegrations/sq cm-sec. The observed level of Po210 activity is in excess of the amount that would be in equilibrium with Rn222 by about an order of magnitude. This implies that larger levels of radon emanation have occurred on the moon within a time scale of 10 to 100 years.

  8. Selective Alpha-Particle Mediated Depletion of Tumor Vasculature with Vascular Normalization

    PubMed Central

    Seshan, Surya V.; Kappel, Barry J.; Chattopadhyay, Debjit; May, Chad; McDevitt, Michael R.; Nolan, Daniel; Mittal, Vivek; Benezra, Robert; Scheinberg, David A.

    2007-01-01

    Background Abnormal regulation of angiogenesis in tumors results in the formation of vessels that are necessary for tumor growth, but compromised in structure and function. Abnormal tumor vasculature impairs oxygen and drug delivery and results in radiotherapy and chemotherapy resistance, respectively. Alpha particles are extraordinarily potent, short-ranged radiations with geometry uniquely suitable for selectively killing neovasculature. Methodology and Principal Findings Actinium-225 (225Ac)-E4G10, an alpha-emitting antibody construct reactive with the unengaged form of vascular endothelial cadherin, is capable of potent, selective killing of tumor neovascular endothelium and late endothelial progenitors in bone-marrow and blood. No specific normal-tissue uptake of E4G10 was seen by imaging or post-mortem biodistribution studies in mice. In a mouse-model of prostatic carcinoma, 225Ac-E4G10 treatment resulted in inhibition of tumor growth, lower serum prostate specific antigen level and markedly prolonged survival, which was further enhanced by subsequent administration of paclitaxel. Immunohistochemistry revealed lower vessel density and enhanced tumor cell apoptosis in 225Ac-E4G10 treated tumors. Additionally, the residual tumor vasculature appeared normalized as evident by enhanced pericyte coverage following 225Ac-E4G10 therapy. However, no toxicity was observed in vascularized normal organs following 225Ac-E4G10 therapy. Conclusions The data suggest that alpha-particle immunotherapy to neovasculature, alone or in combination with sequential chemotherapy, is an effective approach to cancer therapy. PMID:17342201

  9. TEST PROCEDURE FOR GROSS ALPHA PARTICLE ACTIVITY IN DRINKING WATER: INTERLABORATORY COLLABORATIVE STUDY

    EPA Science Inventory

    Gross alpha activity values were calculated with four different alpha emitting radionuclide standard counting efficiencies to see which standard was best for gross alpha activity determinations. Thorium-230, a pure alpha emitter, appeared to be the best standard for gross alpha c...

  10. Differential Effects of Alpha-Particle Radiation and X-Irradiation on Genes Associated with Apoptosis

    PubMed Central

    Chauhan, Vinita; Howland, Matthew; Chen, Jeremy; Kutzner, Barbara; Wilkins, Ruth C.

    2011-01-01

    This study examined differential effects of alpha-(?-) particle radiation and X-rays on apoptosis and associated changes in gene expression. Human monocytic cells were exposed to ?-particle radiation and X-rays from 0 to 1.5?Gy. Four days postexposure, cell death was measured by flow cytometry and 84 genes related to apoptosis were analyzed using real-time PCR. On average, 33% of the cells were apoptotic at 1.5?Gy of ?-particle radiation. Transcript profiling showed statistical expression of 15 genes at all three doses tested. Cells exposed to X-rays were <5% apoptotic at ~1.5?Gy and induced less than a 2-fold expression in 6 apoptotic genes at the higher doses of radiation. Among these 6 genes, Fas and TNF-? were common to the ?-irradiated cells. This data suggests that ?-particle radiation initiates cell death by TNF-? and Fas activation and through intermediate signalling mediators that are distinct from X-irradiated cells. PMID:22091383

  11. Detection of alpha radiation in a beta radiation field

    DOEpatents

    Mohagheghi, Amir H. (Albuquerque, NM); Reese, Robert P. (Edgewood, NM)

    2001-01-01

    An apparatus and method for detecting alpha particles in the presence of high activities of beta particles utilizing an alpha spectrometer. The apparatus of the present invention utilizes a magnetic field applied around the sample in an alpha spectrometer to deflect the beta particles from the sample prior to reaching the detector, thus permitting detection of low concentrations of alpha particles. In the method of the invention, the strength of magnetic field required to adequately deflect the beta particles and permit alpha particle detection is given by an algorithm that controls the field strength as a function of sample beta energy and the distance of the sample to the detector.

  12. 149Sm(n,alpha)146Nd cross sections in the MeV energy region

    SciTech Connect

    Zhang, Guohui [Peking University; Gledenov, Yu. M. [Joint Institute for Nuclear Research, Dubna, Russia; Khuukhenkhuu, G [National University of Mongolia; Sedysheva, M. V. [Joint Institute for Nuclear Research, Dubna, Russia; Szalanski, P. [University of Lodz; Koehler, Paul Edward [ORNL; Voronov, Yu. N. [Joint Institute for Nuclear Research, Dubna, Russia; Liu, Jiaming [Peking University; Liu, Xiang [Peking University; Han, Jinhua [Peking University; Chen, Jinxiang [Peking University

    2011-01-01

    We have measured the {sup 149}Sm(n,{alpha}){sup 146}Nd cross section at 4.5, 5.0, 5.5, 6.0, and 6.5 MeV. Measurements were performed at the 4.5 MV Van de Graaff accelerator of Peking University with monoenergetic neutrons produced via the {sup 2}H(d,n){sup 3}He reaction using a deuterium gas target. Alpha particles were detected with a double-section gridded ionization chamber having two back-to-back {sup 149}Sm{sub 2}O{sub 3} samples attached to the common cathode. Absolute neutron flux was measured using a small {sup 238}U fission chamber and monitored by a BF{sub 3} long counter. These are the first reported cross sections for this reaction at these energies, except at 6.0 eV, where our new data are in good agreement with our earlier result. The present results help to much better constrain the {sup 149}Sm(n,{alpha}){sup 146}Nd cross section in a region where its energy dependence is changing fairly rapidly and there are large differences between evaluated nuclear data libraries.

  13. Correlation between {alpha}-Decay Energies of Superheavy Nuclei Involving the Effects of Symmetry Energy

    SciTech Connect

    Dong Jianmin [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Graduate University of Chinese Academy of Sciences, Beijing 100049 (China); School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China); Institute for Theoretical Physics, Justus-Liebig-University, D-35392 Giessen (Germany); Zuo Wei [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China); Scheid, Werner [Institute for Theoretical Physics, Justus-Liebig-University, D-35392 Giessen (Germany)

    2011-07-01

    A formula for the relationship between the {alpha}-decay energies (Q values) of superheavy nuclei (SHN) is presented, which is composed of the effects of Coulomb energy and symmetry energy. It can be employed not only to validate the experimental observations and measurements to a large extent, but also to predict the Q values of heaviest SHN with a high accuracy generally which will be very useful for future experiments. Furthermore, the shell closures in superheavy region and the effect of the symmetry energy on the stability of SHN against {alpha} decay are discussed with the help of this formula.

  14. High Energy Particles in Tokamaks

    SciTech Connect

    White, R. B. [Plasma Physics Laboratory, Princeton University, P.O. Box 451, Princeton, New Jersey 08543 (United States)

    2008-05-14

    This lecture covers the derivation of guiding center equations in a tokamak, orbit classification, the effect of magnetic perturbations and ripple, the interaction of particles with magnetohydrodynamic modes, including passing particle resonance, toroidal Alfven mode drive and saturation, the fishbone mode, and sawtooth stabilization.

  15. Self-consistent calculations of alpha-decay energies

    SciTech Connect

    Tolokonnikov, S. V.; Lutostansky, Yu. S.; Saperstein, E. E., E-mail: saper@mbslab.kiae.ru [National Research Center Kurchatov Institute (Russian Federation)

    2013-06-15

    On the basis of the self-consistent theory of finite Fermi systems, the energies of alphadecay chains were calculated for several new superheavy nuclei discovered recently in experiments of the Dubna-Livermore Collaboration headed by Yu.Ts. Oganessian. The approach in question is implemented on the basis of the generalized method of the density functional proposed by Fayans and his coauthors. The version used here relies on the functional DF3-a proposed recently for describing a wide array of nuclear data, including data on superheavy nuclei. A detailed comparison of the results obtained on this basis with the predictions of different approaches, including the self-consistent Skyrme-Hartree-Fock method, the micro-macro method in the version developed by Sobiczewski and his coauthors, and the phenomenological method of Liran and his coauthors, is performed. The resulting alpha-decay energies are used to calculate respective lifetimes with the aid of the phenomenological Parkhomenko-Sobiczewski formula.

  16. Complex aberrations in lymphocytes exposed to mixed beams of (241)Am alpha particles and X-rays.

    PubMed

    Staaf, Elina; Deperas-Kaminska, Marta; Brehwens, Karl; Haghdoost, Siamak; Czub, Joanna; Wojcik, Andrzej

    2013-08-30

    Modern radiotherapy treatment modalities are associated with undesired out-of-field exposure to complex mixed beams of high and low energy transfer (LET) radiation that can give rise to secondary cancers. The biological effectiveness of mixed beams is not known. The aim of the investigation was the analysis of chromosomal damage in human peripheral blood lymphocytes (PBL) exposed to a mixed beam of X-rays and alpha particles. Using a dedicated exposure facility PBL were exposed to increasing doses of alpha particles (from (241)Am), X-rays and a mixture of both. Chromosomal aberrations were analysed in chromosomes 2, 8 and 14 using fluorescence in situ hybridisation. The found and expected frequencies of simple and complex aberrations were compared. Simple aberrations showed linear dose-response relationships with doses. A higher than expected frequency of simple aberrations was only observed after the highest mixed beam dose. A linear-quadratic dose response curve for complex aberrations was observed after mixed-beam exposure. Higher than expected frequencies of complex aberrations were observed for the two highest doses. Both the linear-quadratic dose-response relationship and the calculation of expected frequencies show that exposure of PBL to mixed beams of high and low LET radiation leads to a higher than expected frequency of complex-type aberrations. Because chromosomal changes are associated with cancer induction this result may imply that the cancer risk of exposure to mixed beams in radiation oncology may be higher than expected based on the additive action of the individual dose components. PMID:23669292

  17. Astronomy with ultra high-energy particles

    E-print Network

    Joerg R. Hoerandel

    2008-03-20

    Recent measurements of the properties of cosmic rays above 10^17 eV are summarized and implications on our contemporary understanding of their origin are discussed. Cosmic rays with energies exceeding 10^20 eV have been measured, they are the highest-energy particles in the Universe. Particles at highest energies are expected to be only marginally deflected by magnetic fields and they should point towards their sources on the sky. Recent results of the Pierre Auger Observatory have opened a new window to the Universe - astronomy with ultra high-energy particles.

  18. Elastic {alpha}-scattering on proton rich nuclei at astrophysically relevant energies

    SciTech Connect

    Fueloep, Zs.; Gyuerky, Gy.; Kiss, G. G.; Mate, Z.; Somorjai, E. [ATOMKI, P.O. Box 51. H-4001 Debrecen (Hungary); Galaviz, D.; Mohr, P.; Zilges, A. [Technische Universitaet Darmstadt, D-64289 Darmstadt (Germany); Rauscher, T. [Universitaet Basel, CH-4056 Basel (Switzerland)

    2006-07-12

    In order to improve the reliability of statistical model calculations in the region of heavy proton rich nuclei several elastic alpha scattering experiments have been carried out at low bombarding energies on various even-even and semi-magic nuclei. The extracted local optical potential parameters can be compared with the predictions of global alpha potentials. A study on 112,124Sn({alpha},{alpha})112,124Sn has been made to test the global alpha potentials at both the proton and neutron rich sides of an isotopic chain. The present work describes the experimental challenges of high precision scattering experiments at low energy.

  19. Use of neutralized knock-on ion fluxes for alpha-particle confinement studies

    NASA Astrophysics Data System (ADS)

    Nesenevich, V. G.; Afanasyev, V. I.; Goncharov, P. R.; Mironov, M. I.; Petrov, M. P.; Petrov, S. Ya

    2014-12-01

    One of the objectives of neutral particle diagnostics on large tokamaks exploring DT plasma is to measure the distribution functions of fast deuterium (D) and tritium (T) ions in a suprathermal energy range. High energy tails in D,T-ion energy distributions (so-called knock-on ions) appear as a result of close elastic collisions between thermal fuel ions and fusion ?-particles. The knock-on ion density depends directly on the density and energy distribution of the ?-particles. Therefore measurements of the neutralized knock-on D,T-ion fluxes escaping from the plasma volume can provide information on the ?-particle confinement in DT plasma. This paper presents the results of a numerical simulation for the neutralized fast D,T-ion fluxes in the case of ITER fusion plasma. Feasible experimental measurements of the fluxes are considered with respect to the neutral particle diagnostics. We will show that the diagnostics can provide information on the confinement properties of fast ions in DT fusion plasma.

  20. Study of the beta-delayed alpha-particle emission of [sup 16]N

    SciTech Connect

    Zhao, Z.; France, R.H. III; Lai, K.S.; Gai, M. (A.W. Wright Nuclear Structure Laboratory, Department of Physics, Yale University, New Haven, Connecticut 06511 (United States)); Wilds, E.L. (Department of Physics, The University of Connecticut, Storrs, Connecticut 06268 (United States)); Kryger, R.A.; Winger, J.A. (National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824 (United States)); Beard, K.B. (Department of Physics, Hampton University, Hampton, Virgina 23668 (United States))

    1993-07-01

    The beta-delayed alpha-particle emission of [sup 16]N has been studied, with [sup 16]N nuclei produced using 80 MeV/nucleon [sup 18]O beams on [sup 9]Be targets. The [sup 16]N secondary nuclei were mass analyzed and separated from the reaction products using the Michigan State University A1200 isotope separator. A detector array, including four thin surface barrier detectors, a [ital p]-[ital i]-[ital n] diode, a Ge gamma-ray detector, and a two-dimensional position sensitive parallel plate avalanche counter, was used for implantation and study of the separated nuclei. A beta-decay branching ratio of (1.3[plus minus]0.3)[times]10[sup [minus]5] to the 1[sup [minus

  1. Receiver calibration of the JET fast ion and alpha particle diagnostic

    SciTech Connect

    Machuzak, J.S.; Woskov, P.P. (MIT Plasma Fusion Center, Cambridge, Massachusetts 02139 (United States)); Bindslev, H.; Comiskey, M.; Fessey, J.; Hoekzema, J.A.; Hughes, T.P. (JET Joint Undertaking, Abingdon, Oxon OX14 3EA (United Kingdom)); Orsitto, F. (ENEA CRE Frascati (Italy))

    1992-10-01

    A collective Thomson scattering diagnostic is being implemented at JET to diagnose the velocity distribution and density of alpha particles and energetic ions. This diagnostic consists of a number of major subsystems including: a high-power 140-GHz gyrotron, a 32-channel 12-GHz bandwidth heterodyne receiver, efficient corrugated waveguide systems, variable polarizers, and in vacuum beam steering mirrors. Proper calibration of these subsystems for signal level losses, positioning, and polarization is imperative for the successful operation of the diagnostic and to facilitate the interpretation of the scattered data. A low-power Gunn oscillator was used to verify the polarization rotation induced by the seven miter bends in the receiver transmission line. The full bandwidth receiver front end losses, including the sapphire tokamak vacuum window, were initially calibrated by using the hot tokamak vessel wall as a blackbody source at approximately 310 {degree}C. Background ECE measurements will be presented.

  2. Propagation distance of the alpha-particle-induced bystander effect: the role of nuclear traversal and gap junction communication.

    PubMed

    Gaillard, Sylvain; Pusset, David; de Toledo, Sonia M; Fromm, Michel; Azzam, Edouard I

    2009-05-01

    When cell populations are exposed to low-dose alpha-particle radiation, a significant fraction of the cells will not be traversed by a radiation track. However, stressful effects occur in both irradiated and bystander cells in the population. Characterizing these effects, and investigating their underlying mechanism(s), is critical to understanding human health risks associated with exposure to alpha particles. To this end, confluent normal human fibroblast cultures were grown on polyethylene terephthalate foil grafted to an ultrathin solid-state nuclear track detector and exposed under non-perturbing conditions to low-fluence alpha particles from a broadbeam irradiator. Irradiated and affected bystander cells were localized with micrometer precision. The stress-responsive protein p21(Waf1) (also known as CDKN1A) was induced in bystander cells within a 100-microm radius from an irradiated cell. The mean propagation distance ranged from 20 to 40 microm around the intranuclear alpha-particle impact point, which corresponds to a set of approximately 30 cells. Nuclear traversal, induced DNA damage, and gap junction communication were critical contributors to propagation of this stressful effect. The strategy described here may be ideal to investigate the size of radiation-affected target and the relative contribution of different cellular organelles to bystander effects induced by energetic particles, which is relevant to radioprotection and cancer radiotherapy. PMID:19580486

  3. Mitigation of radiation nephropathy after internal {alpha}-particle irradiation of kidneys

    SciTech Connect

    Jaggi, Jaspreet Singh [Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Seshan, Surya V. [Department of Pathology, Cornell University Weill Medical College, New York, NY (United States); McDevitt, Michael R. [Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Sgouros, George [Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD (United States); Hyjek, Elizabeth [Department of Pathology, Cornell University Weill Medical College, New York, NY (United States); Scheinberg, David A. [Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY (United States) and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)]. E-mail: d-scheinberg@ski.mskcc.org

    2006-04-01

    Purpose: Internal irradiation of kidneys as a consequence of radioimmunotherapy, radiation accidents, or nuclear terrorism can result in radiation nephropathy. We attempted to modify pharmacologically, the functional and morphologic changes in mouse kidneys after injection with the actinium ({sup 225}Ac) nanogenerator, an in vivo generator of {alpha}- and {beta}-particle emitting elements. Methods and Materials: The animals were injected with 0.35 {mu}Ci of the {sup 225}Ac nanogenerator, which delivers a dose of 27.6 Gy to the kidneys. Then, they were randomized to receive captopril (angiotensin-converting enzyme inhibitor), L-158,809 (angiotensin II receptor-1 blocker), spironolactone (aldosterone receptor antagonist), or a placebo. Results: Forty weeks after the {sup 225}Ac injection, the placebo-control mice showed a significant increase in blood urea nitrogen (BUN) (87.6 {+-} 6.9 mg/dL), dilated Bowman spaces, and tubulolysis with basement membrane thickening. Captopril treatment accentuated the functional (BUN 119.0 {+-} 4.0 mg/dL; p <0.01 vs. placebo controls) and histopathologic damage. In contrast, L-158,809 offered moderate protection (BUN 66.6 {+-} 3.9 mg/dL; p = 0.02 vs. placebo controls). Spironolactone treatment, however, significantly prevented the development of histopathologic and functional changes (BUN 31.2 {+-} 2.5 mg/dL; p <0.001 vs. placebo controls). Conclusions: Low-dose spironolactone and, to a lesser extent, angiotensin receptor-1 blockade can offer renal protection in a mouse model of internal {alpha}-particle irradiation.

  4. Renal tubulointerstitial changes after internal irradiation with alpha-particle-emitting actinium daughters.

    PubMed

    Jaggi, Jaspreet Singh; Seshan, Surya V; McDevitt, Michael R; LaPerle, Krista; Sgouros, George; Scheinberg, David A

    2005-09-01

    The effect of external gamma irradiation on the kidneys is well described. However, the mechanisms of radiation nephropathy as a consequence of targeted radionuclide therapies are poorly understood. The functional and morphologic changes were studied chronologically (from 10 to 40 wk) in mouse kidneys after injection with an actinium-225 (225Ac) nanogenerator, a molecular-sized, antibody-targeted, in vivo generator of alpha-particle-emitting elements. Renal irradiation from free, radioactive daughters of 225Ac led to time-dependent reduction in renal function manifesting as increase in blood urea nitrogen. The histopathologic changes corresponded with the decline in renal function. Glomerular, tubular, and endothelial cell nuclear pleomorphism and focal tubular cell injury, lysis, and karyorrhexis were observed as early as 10 wk. Progressive thinning of the cortex as a result of widespread tubulolysis, collapsed tubules, glomerular crowding, decrease in glomerular cellularity, interstitial inflammation, and an elevated juxtaglomerular cell count were noted at 20 to 30 wk after treatment. By 35 to 40 wk, regeneration of simplified tubules with tubular atrophy and loss with focal, mild interstitial fibrosis had occurred. A lower juxtaglomerular cell count with focal cytoplasmic vacuolization, suggesting increased degranulation, was also observed in this period. A focal increase in tubular and interstitial cell TGF-beta1 expression starting at 20 wk, peaking at 25 wk, and later declining in intensity with mild increase in the extracellular matrix deposition was noticed. These findings suggest that internally delivered alpha-particle irradiation-induced loss of tubular epithelial cells triggers a chain of adaptive changes that result in progressive renal parenchymal damage accompanied by a loss of renal function. These findings are dissimilar to those seen after gamma or beta irradiation of kidneys. PMID:15987754

  5. Cross-sections for Balmer-alpha excitation in heavy-particle collisions

    SciTech Connect

    Bae, Y.K.

    1982-08-01

    Doppler shifted and unshifted Balmer-alpha radiation has been observed in the absolute sense for energetic H/sup +/, H/sub 2//sup +/ and H/sub 3//sup +/ ions incident on molecular hydrogen by the method of decay inside the target within the energy range of 20 keV to 150 keV. Most of the measurements were based on single-collision conditions, but a simple thick-target experiment has been tried for the case of dissociative excitation of the target molecules by H atoms.

  6. On alpha heating in toroidal devices

    Microsoft Academic Search

    G. H. Miley

    1979-01-01

    Studies of the alpha particle losses and heating profiles for an alpha-heated TFTR-sized tokamak and a small field-reversed mirror reactor (FRM) are presented. The slowing-down and drift of high-energy alpha particles, including detailed orbital effects, is approximated for tokamak geometry using the SYMALF multi-energy-angle code. Results of the calculation for a beam-driven TFTR-type plasma indicate that, except for the center

  7. Formation of the isomeric pair {sup 194}Ir{sup m,g} in interactions of {alpha} particles with {sup 192}Os

    SciTech Connect

    Uddin, M. S.; Qaim, S. M. [Institut fuer Neurowissenschaften und Medizin, INM-5: Nuklearchemie, Forschungszentrum Juelich, D-52425 Juelich (Germany); Sudar, S. [Institut fuer Neurowissenschaften und Medizin, INM-5: Nuklearchemie, Forschungszentrum Juelich, D-52425 Juelich (Germany); Institute of Experimental Physics, Debrecen University, H-4001 Debrecen (Hungary)

    2011-08-15

    Cross sections were measured by the activation technique for the nuclear processes {sup 192}Os({alpha},d+pn+np){sup 194}Ir{sup m,g} up to {alpha}-particle energies of 39 MeV. From the measured data the isomeric cross-section ratio was deduced as a function of projectile energy. The present experimental data as well as those for the {sup 194}Pt(n,p){sup 194}Ir{sup m,g} reaction, given in the literature, were compared with the results of nuclear model calculations using the code talys, which combines the statistical, precompound, and direct interactions. In general, the experimental data were reproduced well by the model calculations, which were done using relatively low values of {eta} (i.e., {Theta}{sub eff}/{Theta}{sub rigid}). The results provide more evidence for the mass dependence of {eta}. The level density parameter for {sup 194}Ir was determined unambiguously.

  8. Alpha-quartz-induced chemokine expression by rat lung epithelial cells: effects of in vivo and in vitro particle exposure.

    PubMed Central

    Driscoll, K. E.; Howard, B. W.; Carter, J. M.; Asquith, T.; Johnston, C.; Detilleux, P.; Kunkel, S. L.; Isfort, R. J.

    1996-01-01

    Chemokines are chemotactic cytokines that can play a key role in leukocyte recruitment to sites of tissue injury or infection. Previous studies have demonstrated that exposure to alpha-quartz as well as other noxious particles increases chemokine gene expression in rat lung, although the cells responsible for chemokine expression and the mechanisms underlying this response have remained unclear. The present studies demonstrate that exposure of rats to alpha-quartz induced expression of mRNA for the chemokine macrophage-inflammatory protein (MIP)-2 in epithelial cells lining the terminal bronchioles and alveolar ducts as well as macrophages and alveolar type II cells in the more distal lung. Treatment of rats with an anti-MIP-2 antiserum before alpha-quartz exposure markedly attenuated neutrophilic infiltration of the lungs demonstrating an important role for MIP-2 in alpha-quartz-induced pulmonary inflammation. In vitro exposure of primary cultures of rat alveolar type II cells or the rat alveolar type II cell line RLE-6TN to tumor necrosis factor-alpha, endotoxin, or alpha-quartz increased mRNA for MIP-2 as well as the structurally and functionally similar chemokine cytokine-induced neutrophil chemoattractant but not the chemokine MIP-1 alpha. The alpha-quartz-induced increase in epithelial MIP-2 mRNA resulted, at least in part, from increased gene transcription and was associated with the release of active MIP-2 protein. Induction of RLE-6TN MIP-2 and cytokine-induced neutrophil chemoattractant mRNA expression was not unique to alpha-quartz, being also increased by crocidolite asbestus fibers but not by titanium dioxide or MMVF-10 glass fibers. These findings indicate that epithelial cells contribute to chemokine expression in rat lung after exposure to alpha-quartz and potentially other noxious particles and suggest that alpha-quartz-activated MIP-2 expression in vivo results, at least in part, from a direct action of the particles on the lung epithelium. Images Figure 1 Figure 3 Figure 5 Figure 6 Figure 7 Figure 8 PMID:8909252

  9. 2948 IEEE TRANSACTIONS ON PLASMA SCIENCE, VOL. 39, NO. 11, NOVEMBER 2011 Simulation of Alpha Particles in Rotating Plasma

    E-print Network

    throat, and these electrodes limited the rotation speed to the Alfven critical ionization velocity (CIV2948 IEEE TRANSACTIONS ON PLASMA SCIENCE, VOL. 39, NO. 11, NOVEMBER 2011 Simulation of Alpha Particles in Rotating Plasma Interacting With a Stationary Ripple Abraham J. Fetterman and Nathaniel J

  10. Channeling of Fusion Alpha-Particle Power Using Minority Ion Catalysis A. I. Zhmoginov and N. J. Fisch

    E-print Network

    , with electrons kept cold, so that the effective fusion reactivity can be increased [9­11]. The meansChanneling of Fusion Alpha-Particle Power Using Minority Ion Catalysis A. I. Zhmoginov and N. J greatly facilitate controlled nuclear fusion. The parameter range for achieving this temperature disparity

  11. Determination of Geometry and Absorption Effects and Their Impact on the Accuracy of Alpha Particle Soft Error Rate Extrapolations

    Microsoft Academic Search

    Robert C. Baumann; Daniele Radaelli

    2007-01-01

    The results of a physical experiment and extensive simulation runs are presented for the first time demonstrating the significant effects of geometry and air absorption on accelerated alpha particle soft error rate tests. These results show that geometry and absorption must be properly accounted for even when the source is in close proximity to the device to avoid substantial underestimation

  12. Determining the impact of alpha-particle-emitting contamination from the Fukushima Daiichi disaster on Japanese manufacturing sites

    Microsoft Academic Search

    Robert C. Baumann

    2011-01-01

    We briefly review nuclear reactor operation from the point of view of the major radioactive contaminants formed and consider how these were released and dispersed into the air, water, and soil around Fukushima. The risk of contamination from alpha-particle-emitting uranium and plutonium isotopes at semiconductor manufacturing sites in Japan is considered from theoretical aspects. We report the results of low

  13. Production and evaluation of ZnS thin films by the MOCVD technique as alpha-particle detectors

    Microsoft Academic Search

    H. Kashani

    1996-01-01

    Zinc sulphide thin films are deposited on several substrates such as glass, quartz, silicon, Teflon and Mylar. The chemical reaction of hydrogen sulphide with dimethylzinc is utilised for the deposition process. The optimum working conditions (deposition rate versus flow rate, temperature and pressure) are obtained. The acquired films are characterised and the films are examined for alpha-particle sensitivity. In general,

  14. Annual energy consumption prediction using particle filters

    Microsoft Academic Search

    Osamah A. Alsayegh

    2003-01-01

    This paper presents a framework for predicting the monthly-annual electric energy consumption (EC) using practical filters, sequential Monte Carlo methods. The particle filtering technique is utilized to describe and track the EC \\

  15. Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination

    SciTech Connect

    Nagasawa, H; Wilson, P F; Chen, D J; Thompson, L H; Bedford, J S; Little, J B

    2007-10-26

    We reported previously that the homologous recombinational repair (HRR)-deficient Chinese hamster mutant cell line irs3 (deficient in the Rad51 paralog Rad51C) showed only a 50% spontaneous frequency of sister chromatid exchange (SCE) as compared to parental wild-type V79 cells. Furthermore, when irradiated with very low doses of alpha particles, SCEs were not induced in irs3 cells, as compared to a prominent bystander effect observed in V79 cells (Nagasawa et al., Radiat. Res. 164, 141-147, 2005). In the present study, we examined additional Chinese hamster cell lines deficient in the Rad51 paralogs Rad51C, Rad51D, Xrcc2, and Xrcc3 as well as another essential HRR protein, Brca2. Spontaneous SCE frequencies in non-irradiated wild-type cell lines CHO, AA8 and V79 were 0.33 SCE/chromosome, whereas two Rad51C-deficient cell lines showed only 0.16 SCE/chromosome. Spontaneous SCE frequencies in cell lines defective in Rad51D, Xrcc2, Xrcc3, and Brca2 ranged from 0.23-0.33 SCE/chromosome, 0-30% lower than wild-type cells. SCEs were induced significantly 20-50% above spontaneous levels in wild-type cells exposed to a mean dose of 1.3 mGy of alpha particles (<1% of nuclei traversed by an alpha particle). However, induction of SCEs above spontaneous levels was minimal or absent after {alpha}-particle irradiation in all of the HRR-deficient cell lines. These data suggest that Brca2 and the Rad51 paralogs contribute to DNA damage repair processes induced in bystander cells (presumably oxidative damage repair in S-phase cells) following irradiation with very low doses of alpha particles.

  16. Low-energy cross sections in the {sup 12}C({alpha},{gamma}){sup 16}O reaction

    SciTech Connect

    Katsuma, M. [Institut d'Astronomie et d'Astrophysique, Universite Libre de Bruxelles, CP226, B-1050 Brussels (Belgium)

    2008-09-15

    The low-energy {sup 12}C({alpha},{gamma}){sup 16}O reaction is analyzed with the potential model. The potentials are chosen from the deep potential describing the {alpha}-particle nuclear rainbow phenomena at high energies. Below E{sub c.m.}=1 MeV, the cross section is found to be dominated by the E2 transition to the ground state of {sup 16}O. No enhancement of the E1 component at low energies is predicted. The extrapolated astrophysical S-factors at E{sub c.m.}=0.3 MeV are S{sub E2}=150 keV b and S{sub E1}=3 keV b.

  17. Pairing gaps and Fermi energies at scission for 296Lv alpha-decay

    E-print Network

    M. Mirea

    2014-11-12

    The pairing corrections, the single particle occupation numbers, are investigated within density-dependent delta interaction formalism for pairing residual interactions. The potential barrier is computed in the framework of the macroscopic-microscopic model. The microscopic part is based on the Woods-Saxon two center shell model. The alpha-decay of a superheavy element is treated, by paying a special attention to the region of the scission configurations. The sequence of nuclear shapes follows the superasymmetric fission path for alpha decay. It was found that the pairing gaps of the states that reach asymptotically the potential well of the alpha particle have large values at scission but become zero after scission. The 1s1/2 single particle levels of the nascent alpha particle are fully occupied while the superior levels are empties in the scission region and remains in the same states during the penetration of the Coulomb barrier. The projection of the numbers of particle on the two fragments are obtained naturally. At scission, the nascent alpha particle forms a very bound cluster.

  18. Biophysical analysis of the dose-dependent overdispersion and the restricted linear energy transfer dependence expressed in dicentric chromosome data from alpha-irradiated human lymphocytes.

    PubMed

    Greinert, R; Harder, D

    1997-06-01

    Experimental data for the induction of dicentric chromosomes in phytohemagglutinin (PHA)-stimulated human T lymphocytes by 241Am alpha-particles obtained by Schmid et al. have been analyzed in the light of biophysical theory. As usual in experiments with alpha-particles, the relative variance of the intercellular distribution of the number of aberrations per cell exceeds unity, and the multiplicity of the aberrations per particle traversal through the cell is understood as the basic effect causing this overdispersion. However, the clearly expressed dose dependence of the relative variance differs from the dose-independent relative variance predicted by the multiplicity effect alone. Since such dose dependence is often observed in experiments with alpha-particles, protons, and high-energy neutrons, the interpretation of the overdispersion needs to be supplemented. In a new, more general statistical model, the distribution function of the number of aberrations is interpreted as resulting from the convolution of a Poisson distribution for the spontaneous aberrations with the overdispersed distributions for the aberrations caused by intratrack or intertrack lesion interaction, and the fluctuation of the cross-sectional area of the cellular chromatin must also be considered. Using a suitable mathematical formulation of the resulting dose-dependent over-dispersion, the mean number lambda 1 of the aberrations produced by a single particle traversal through the cell nucleus and the mean number lambda 2 of the aberrations per pairwise approach between two alpha-particle tracks could be estimated. Coefficient alpha of the dose-proportional yield component, when compared between 241Am alpha-particle irradiation and 137Cs gamma-ray exposure, is found to increase approximately in proportion to dose-mean restricted linear energy transfer, which indicates an underlying pairwise molecular lesion interaction on the nanometer scale. PMID:9271796

  19. An investigation of alpha-like particles in the DIII-D tokamak using fusion-product diagnostics

    SciTech Connect

    Duong, H.H.

    1993-01-01

    Two important issues associated with alpha physics, the single-particle behavior and the effect of collective fast-ion-driven instabilities on fast-ion confinement, have been studied in the DIII-D tokamak using fusion product diagnostics. The single-particle behavior of alpha-like tritons and [sup 3]He ions produced in deuterium-deuterium fusion reactions is studied using the d(t,n)[alpha] and d([sup 3]he,p)[alpha] fusion reactions. Fusion-produced MeV ions exhibit classical behavior in high field (B[sub T] [ge] 1.0 T) DIII-D discharges, including the new class of [open quotes]very high[close quotes] confinement plasmas. However, discharges with strong sawtooth, fishbone, or TAE activity exhibit anomalous fusion product losses. For the high field discharges without strong MHD activity, the data imply an effective diffusion coefficient smaller than [approximately]0.1 m[sup 2]/s, but in the presence of strong MHD activity, the effective diffusion of the MeV ions exceeds 1.0 m[sup 2]/s. Collective alpha particle processes are simulated by means of neutral beam injected energetic ion minorities. Toroidicity-induced Alfven Eigenmodes (TAE) are observed in DIII-D when energetic beam ions ([approximately]75 keV) are used to destabilize the mode. Measurements of the neutron emission indicate that up to 70% of the injected power is lost during strong TAE activity. Measurements of the poloidal distribution of fast-ion losses suggest that the losses are greatest near the vessel midplane. Fast-ion losses in discharges with combined fishbones and TAE bursts are 1.5 to 2 times greater than losses in fishbone discharges without TAE activity. The scaling of fast ion losses with MHD mode amplitude exhibits no threshold in the mode amplitude, suggesting that mode-particle pumping is the dominant loss mechanism.

  20. Minimum ionizing and alpha particles detectors based on epitaxial semiconductor silicon carbide

    Microsoft Academic Search

    F. Nava; P. Vanni; M. Bruzzi; S. Lagomarsino; S. Sciortino; G. Wagner; C. Lanzieri

    2004-01-01

    The relatively high value of the energy required to produce an electron-hole pair in silicon carbide, SiC, by a minimum ionizing particle (MIP) against the value for Si, imposes severe constrains in the crystallographic quality, the thickness and the doping concentration of the SiC epitaxial layer used as the detection medium. In this work, a 40 ?m thick 4 H-SiC

  1. Investigation on polycrystalline CVD diamond-based alpha-particle detectors

    Microsoft Academic Search

    S. G Wang; Q Zhang; S. F Yoon; J Ahn

    2002-01-01

    In this paper, ?-particle detectors have been fabricated using good quality polycrystalline CVD diamond thin films deposited by HFCVD technique. Coplanar electrical contacts with interelectrode spacing of 100?m were prepared on the growth side of the CVD diamond film using lift-off technology. The detector performance has been tested with a 241Am source with a characteristic energy of 5.5MeV at room

  2. Inelastic Alpha Scattering Studies of Low-Energy Octupole Resonance 

    E-print Network

    Moss, JM; Brown, D. R.; Youngblood, David H.; Rozsa, C. M.; Bronson, J. D.

    1978-01-01

    the calculation to correct- ly reproduce the excitation energy of the first 3 state in each nucleus. For '"Au and "'Pb the strength was determined from the 2.61 MeV 3 in 30'Pb. Figure 6 shows the results of the calcula- tions compared to the LEQR data... A &M University, College Station, Texas 77843 (Received 21 February 1978) Seams of 96 and 115 MeV a particles have been used to study the distribution of isoscalar octupole strength in 1& nuclei from ' Ca to ' 'Pb. A prominent broad peak (I ?2...

  3. Summary of the IEA Workshop on Alpha Physics and Tritium Issues in Large Tokamaks

    SciTech Connect

    Cheng, C.Z.; Stratton, B.; Zweben, S.J. [Princeton Univ., NJ (United States). Plasma Physics Lab.; Pitcher, C.S. [Toronto Univ., Downsview, ON (Canada)

    1993-11-01

    A brief summary is presented of the talks given during this meeting, which was held at PPPL and sponsored by the IEA (International Energy Agency) as part of the Large Tokamak collaboration. These talks are summarized into four sessions: tritium issues in large tokamaks, alpha particle simulation experiments, alpha particle theory, and alpha particle diagnostics.

  4. Radioactive Positron Emitter Production by Energetic Alpha Particles in Solar Flares

    NASA Astrophysics Data System (ADS)

    Murphy, R. J.; Kozlovsky, B.; Share, G. H.

    2014-12-01

    Measurements of the 0.511 MeV positron-annihilation line from solar flares are used to explore the flare process in general and ion acceleration in particular. In flares, positrons are produced primarily by the decay of radioactive positron-emitting isotopes resulting from nuclear interactions of flare-accelerated ions with ambient solar material. Kozlovsky et al. provided ion-energy-dependent production cross sections for 67 positron emitters evaluated from their threshold energies (some <1 MeV nucleon-1) to a GeV nucleon-1, incorporating them into a computer code for calculating positron-emitter production. Adequate cross-section measurements were available for proton reactions, but not for ?-particle reactions where only crude estimates were possible. Here we re-evaluate the ?-particle cross sections using new measurements and nuclear reaction codes. In typical large gamma-ray line flares, proton reactions dominate positron production, but ?-particle reactions will dominate for steeper accelerated-ion spectra because of their relatively low threshold energies. With the accelerated-3He reactions added previously, the code is now reliable for calculating positron production from any distribution of accelerated-ion energies, not just those of typical flares. We have made the code available in the online version of the Journal. We investigate which reactions, projectiles, and ion energies contribute to positron production. We calculate ratios of the annihilation-line fluence to fluences of other gamma-ray lines. Such ratios can be used in interpreting flare data and in determining which nuclear radiation is most sensitive for revealing acceleration of low-energy ions at the Sun.

  5. RADIOACTIVE POSITRON EMITTER PRODUCTION BY ENERGETIC ALPHA PARTICLES IN SOLAR FLARES

    SciTech Connect

    Murphy, R. J. [Code 7650, Naval Research Laboratory, Washington, DC 20375 (United States); Kozlovsky, B. [Tel Aviv University, Tel Aviv (Israel); Share, G. H., E-mail: murphy@ssd5.nrl.navy.mil, E-mail: benz@wise.tau.ac.il, E-mail: share@astro.umd.edu [University of Maryland, College Park, MD 20742 (United States)

    2015-01-01

    Measurements of the 0.511 MeV positron-annihilation line from solar flares are used to explore the flare process in general and ion acceleration in particular. In flares, positrons are produced primarily by the decay of radioactive positron-emitting isotopes resulting from nuclear interactions of flare-accelerated ions with ambient solar material. Kozlovsky et al. provided ion-energy-dependent production cross sections for 67 positron emitters evaluated from their threshold energies (some <1 MeV nucleon{sup –1}) to a GeV nucleon{sup –1}, incorporating them into a computer code for calculating positron-emitter production. Adequate cross-section measurements were available for proton reactions, but not for ?-particle reactions where only crude estimates were possible. Here we re-evaluate the ?-particle cross sections using new measurements and nuclear reaction codes. In typical large gamma-ray line flares, proton reactions dominate positron production, but ?-particle reactions will dominate for steeper accelerated-ion spectra because of their relatively low threshold energies. With the accelerated-{sup 3}He reactions added previously, the code is now reliable for calculating positron production from any distribution of accelerated-ion energies, not just those of typical flares. We have made the code available in the online version of the Journal. We investigate which reactions, projectiles, and ion energies contribute to positron production. We calculate ratios of the annihilation-line fluence to fluences of other gamma-ray lines. Such ratios can be used in interpreting flare data and in determining which nuclear radiation is most sensitive for revealing acceleration of low-energy ions at the Sun.

  6. Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents.

    PubMed

    Henriksen, Gjermund; Bruland, Oyvind S; Larsen, Roy H

    2004-01-01

    The present study explores the use of alpha-particle-emitting, bone-seeking agents as candidates for targeted radiotherapy. Actinium and thorium 1,4,7,10 tetraazacyclododecane N,N',N'',N''' 1,4,7,10-tetra(methylene) phosphonic acid (DOTMP) and thorium-diethylene triamine N,N',N'' penta(methylene) phosphonic acid (DTMP) were prepared and their biodistribution evaluated in conventional Balb/C mice at four hours after injection. All three bone-seeking agents showed a high uptake in bone and a low uptake in soft tissues. Among the soft tissue organs, only kidney had a relatively high uptake. The femur/kidney ratios for 227Th-DTMP, 228-Ac-DOTMP and 227Th-DOTMP were 14.2, 7.6 and 6.0, respectively. A higher liver uptake of 228Ac-DOTMP was seen than for 227Th-DTMP and 227Th-DOTMP. This suggests that some demetallation of the 228Ac-DOTMP complex had occurred. The results indicate that 225Ac-DOTMP, 227Th-DOTMP and 227Th-DTMP have promising properties as potential therapeutic bone-seeking agents. PMID:15015582

  7. The Alpha Particle X-Ray Spectrometer (APXS): Results from Gusev Crater and Calibration Report

    NASA Technical Reports Server (NTRS)

    Gellert, R.; Rieder, R.; Brueckner, J.; Clark, B.; Dreibus, G.; Klingelhoefer, G.; Lugmair, G.; Ming, D.; Waenke, H.; Yen, A.; Zipfel, J.; Squyres, S.

    2006-01-01

    The chemical composition of rocks and soils on Mars analyzed during the Mars Exploration Rover Spirit Mission was determined by X-ray analyses with the Alpha Particle X-Ray Spectrometer (APXS). Details of the data analysis method and the instrument calibration are presented. Measurements performed on Mars to address geometry effects and background contributions are shown. Cross calibration measurements among several instrument sensors and sources are discussed. An unintentional swap of the two flight instruments is evaluated. New concentration data acquired during the first 470 sols of rover Spirit in Gusev Crater are presented. There are two geological regions, the Gusev plains and the Columbia Hills. The plains contain soils that are very similar to previous landing sites on Mars. A meteoritic component in the soil is identified. Rocks in the plains revealed thin weathering rinds. The underlying abraded rock was classified as primitive basalt. One of these rocks contained significant Br that is probably associated with vein-filling material of different composition. One of the trenches showed large subsurface enrichments of Mg, S, and Br. Disturbed soils and rocks in the Columbia Hills revealed different elemental compositions. These rocks are significantly weathered and enriched in mobile elements, such as P, S, Cl, or Br. Even abraded rock surfaces have high Br concentrations. Thus, in contrast to the rocks and soils in the Gusev Plains, the Columbia Hills material shows more significant evidence of ancient aqueous alteration.

  8. Stopping of 0.3 1.2 MeV/u protons and alpha particles in Si

    NASA Astrophysics Data System (ADS)

    Abdesselam, M.; Ouichaoui, S.; Azzouz, M.; Chami, A. C.; Siad, M.

    2008-09-01

    The stopping cross sections ?(E) of silicon for protons and alpha particles have been measured over the velocity range 0.3-1.2 MeV/u from a Si//SiO2//Si (SIMOX) target using the Rutherford backscattering spectrometry (RBS) with special emphasis put on experimental aspects. A detection geometry coupling simultaneously two solid-state Si detectors placed at 165° and 150° relative to each side of the incident beam direction was used to measure the energies of the scattered ions and determine their energy losses within the stopping medium. In this way, the basic energy parameter, Ex, at the Si/SiO2 interface for a given incident energy E0 is the same for ions backscattered in the two directions off both the Si and O target elements, and systematic uncertainties in the ?(E) data mainly originating from the target thickness are significantly minimized. A powerful computer code has been elaborated for extracting the relevant ?(E) experimental data and the associated overall uncertainty that amounts to less than 3%. The measured ?(E) data sets were found to be in fair agreement with Paul's compilation and with values calculated by the SRIM 06 computer code. In the case of 4He+ ions, experimental data for the ? effective charge parameter have been deduced by scaling the measured stopping cross sections to those of protons crossing the same target with the same velocity, and compared to the predictions of the SRIM 06 computer code. It is found that the ?-parameter values generated by the latter code slightly deviate from experiment over the velocity region around the stopping cross section maximum where strong charge exchanges usually occur.

  9. Particle size and interfacial effects on heat transfer characteristics of water and {alpha}-SiC nanofluids.

    SciTech Connect

    Timofeeva, E.; Smith, D. S.; Yu, W.; France, D. M.; Singh, D.; Routbort, J. L. (Energy Systems); ( NE); (Univ. of Illinois)

    2010-01-01

    The effect of average particle sizes on basic macroscopic properties and heat transfer performance of {alpha}-SiC/water nanofluids was investigated. The average particle sizes, calculated from the specific surface area of nanoparticles, were varied from 16 to 90 nm. Nanofluids with larger particles of the same material and volume concentration provide higher thermal conductivity and lower viscosity increases than those with smaller particles because of the smaller solid/liquid interfacial area of larger particles. It was also demonstrated that the viscosity of water-based nanofluids can be significantly decreased by pH of the suspension independently from the thermal conductivity. Heat transfer coefficients were measured and compared to the performance of base fluids as well as to nanofluids reported in the literature. Criteria for evaluation of the heat transfer performance of nanofluids are discussed and optimum directions in nanofluid development are suggested.

  10. High energy proton and alpha radiation effects on GaAs/AlGaAs quantum well infrared photodetectors

    SciTech Connect

    Khanna, S.M. [Defence Research Establishment Ottawa, Ontario (Canada)] [Defence Research Establishment Ottawa, Ontario (Canada); Liu, H.C.; Wilson, P.H.; Li, L.; Buchanan, M. [National Research Council, Ottawa, Ontario (Canada). Inst. of Microstructural Sciences] [National Research Council, Ottawa, Ontario (Canada). Inst. of Microstructural Sciences

    1996-12-01

    Gallium arsenide quantum well infrared photodetectors (QWIPs) are ideally suited for infrared imagery due to their detection capability over a wide infrared wavelength region and the feasibility of fabrication of monolithic two-dimensional arrays of such detectors. This paper reports on the effects of high energy proton and alpha particle radiations on the performance of these devices. The particle energies ranged from 0.8 MeV to 10.0 MeV and the fluences used in this work ranged from 10{sup 11} to 10{sup 16}cm{sup {minus}2}. The dark current and spectral response of these radiated devices were measured at different fluence levels. Using the spectral response as a measure of device performance, it is concluded that the device performance decreases with fluence and the degradation due to alpha particles is greater than for protons of the same energy. Further, the damage to device performance decreases with the increase in the energy of both types of these radiations. From prior work, it was expected that these devices would be sensitive to permanent radiation damage. The extent of damage, however, could not be pre-judged due to the device complexity. These are the first reported measurements of radiation hardness of QWIPs.

  11. Initial observations of low energy charged particles near the earth's bow shock on ISEE-1

    NASA Technical Reports Server (NTRS)

    Ipavich, F. M.; Gloeckler, G.; Fan, C. Y.; Fisk, L. A.; Hovestadt, D.; Klecker, B.; Scholer, M.; Ogallagher, J. J.

    1979-01-01

    Initial measurements from the ULECA sensor of the Max-Planck-Institut/University of Maryland experiment on ISEE 1 are reported. ULECA is an electrostatic deflection - total energy sensor consisting of a collimator, a deflection analyzer, and an array of solid-state detectors. The position of a given detector, which determines the energy per charge of an incident particle, together with the measured energy, determines the particle's charge state. It is found that a rich variety of phenomena are operative in the transthermal energy regime (about 10 keV/Q to 100 keV/Q) covered by ULECA. Specifically, observations are presented of locally accelerated protons, alpha particles, and heavier ions in the magnetosheath and upstream of earth's bow shock. Preliminary analysis indicates that the behavior of these locally accelerated particles is most similar at the same energy per charge.

  12. Single and multiple cross sections for ionizing processes of biological molecules by protons and alpha-particle impact: a classical Monte Carlo approach.

    PubMed

    Abbas, I; Champion, C; Zarour, B; Lasri, B; Hanssen, J

    2008-02-21

    A classical trajectory model has been used to predict total cross sections of single and double ionizing processes (including capture processes) for several ion-biological molecule collisional systems in the intermediate and high energy range. In this work, the systems studied are water, adenine or cytosine targets ionized by protons and alpha-particles with kinetic energies ranging from 25 keV amu(-1) to 3000 keV amu(-1). In our approach, we have combined several features of two classical methods namely the classical trajectory Monte Carlo (CTMC) and the classical over-barrier (COB) models. For the water target, our results are compared, for high kinetic energies of incident particles, to the available experimental and theoretical results, and reasonable agreement are generally observed especially for the single ionization (liberated electron moves freely after the collision) and the single capture (liberated electron captured by the projectile), both processes representing ionizing processes. Considering the double ionizing processes which have been largely less studied, the unique comparison concerns the double capture process for alpha+H(2)O collision for which we reproduce the experiment reasonably well. Finally, we present total cross sections of single and double ionizing processes for biological targets such as adenine and cytosine where no experimental results exist till now. PMID:18263940

  13. Alpha-particle capture reactions in inverse kinematics relevant to p-process nucleosynthesis

    NASA Astrophysics Data System (ADS)

    Uji?, P.; Lagoyannis, A.; Mertzimekis, T. J.; de Oliveira Santos, F.; Harissopulos, S.; Demetriou, P.; Perrot, L.; Stodel, Ch.; Saint-Laurent, M.-G.; Kamalou, O.; Lefebvre-Schuhl, A.; Spyrou, A.; Amthor, M. A.; Grevy, S.; Caceres, L.; Koivisto, H.; Laitinen, M.; Uusitalo, J.; Julin, R.

    2011-10-01

    The first feasibility study of an ?-particle capture reaction in inverse kinematics at energies relevant to the p process was performed at the Wien Filter of the LISE spectrometer at GANIL. Hereby, the 4He(78Kr,?)82Sr reaction was investigated using as target an 4He-implanted thin Al foil. The analysis of the data has shown that the determination of (?,?) reaction cross sections at rather low energies around 2 MeV/u in inverse kinematics is indeed feasible regarding the high rejection rate of the primary beam, which in the present work was better than a factor of 109. However, the expected position of the recoils of interest was completely masked by particles of currently unknown origin that could hardly be attributed to scattering of the primary beam. The most probable explanation for the origin of these "pollutants" could be microscopic dust particles of 10 ?m diameter and less, that are extremely difficult to avoid in standard experimental conditions. Hence, the use of a gas-jet target instead of a solid one is compulsory.

  14. Effect of Differential Flow of Alpha Particles on Proton Pressure Anisotropy Instabilities in the Solar Wind

    NASA Astrophysics Data System (ADS)

    Podesta, John J.; Gary, S. Peter

    2011-11-01

    In the solar wind, when the effects of proton-proton Coulomb collisions are negligible, alpha particles usually flow faster than the protons in such a way that the differential alpha-proton flow velocity V d = V ? - V p is on the order of the Alfvén speed, is directed away from the Sun, and is nearly aligned with the local mean magnetic field. When this differential flow is taken into account, solutions of the hot plasma dispersion relation show that for the parallel propagating electromagnetic ion cyclotron (EMIC) instability driven by the proton temperature anisotropy T bottomp > T parp , the maximum growth rate occurs in the + V d direction and for the parallel firehose instability driven by the opposite proton temperature anisotropy T parp > T bottomp , the maximum growth rate occurs in the - V d direction. Thus, the EMIC instability preferentially generates left circularly polarized Alfvén-ion-cyclotron waves propagating away from the Sun and the parallel firehose instability preferentially generates right circularly polarized magnetosonic-whistler waves propagating toward the Sun with the maximum growth rates occurring for frequencies on the order of the proton cyclotron frequency and wavenumbers on the order of the proton inertial length. Because of the Doppler shift caused by the motion of the solar wind, both types of waves are left circularly polarized in the spacecraft frame for observations taken when the local mean magnetic field is collinear with the solar wind flow velocity. Theoretical investigation of these instabilities also shows that regions of parameter space exist where the unstable waves are generated propagating unidirectionally such as, for the EMIC instability for example, when the temperature anisotropy is small |(T bottomp /T parp ) - 1| < 1. Taken together, the above properties can explain the origin of parallel propagating electromagnetic waves recently observed near the proton inertial length in high-speed solar wind. The observed waves are most likely produced in situ by these instabilities. A remarkable property of the proposed mechanism that may be of practical importance is that the magnetic helicity of the unstable waves has the same sign no matter whether the proton temperature anisotropy (T pbottom/T ppar) - 1 is positive or negative.

  15. {alpha}-decay energy formula for superheavy nuclei based on the liquid-drop model

    SciTech Connect

    Dong Tiekuang [Department of Physics, Nanjing University, Nanjing 210008 (China); Faculty of Information Technology, Macau University of Science and Technology, Macau 999078 (China); Ren Zhongzhou [Department of Physics, Nanjing University, Nanjing 210008 (China); Center of Theoretical Nuclear Physics, National Laboratory of Heavy-Ion Accelerator, Lanzhou 730000 (China)

    2010-09-15

    A formula of {alpha}-decay energy for superheavy nuclei based on the method of macroscopic model plus shell corrections is proposed. The macroscopic part of this formula is derived from the Bethe-Weizsaecker binding energy formula, and the shell corrections at N=152 and N=162 are expressed by the Mexican hat wavelet functions. The parameters of this formula are obtained through fitting to 170 {alpha}-decay energies for nuclei ranging from Z=90 to Z=118 with N{>=}140. Numerical results show that 170 existing {alpha}-decay energies can be reproduced very well; the average and standard deviations between theoretical results and experimental data are 0.177 and 0.226 MeV, respectively. The {alpha}-decay energies of newly synthesized nuclei {sup 293,294}117 and their {alpha}-decay products are also reproduced very well. In addition, the {alpha}-decay energies for nuclei with Z=110-120 are predicted and compared with the results calculated by the macroscopic-microscopic model. Great differences are found for nuclei with Z{>=}116 and N{>=}176 due to the shell effects near the hypothetical doubly magic nucleus {sup 298}114{sub 184} in the macroscopic-microscopic model. Therefore, by comparing experimental {alpha}-decay energies measured in the future with the ones predicted by these two methods, one can obtain useful information about the next proton and neutron magic numbers.

  16. High energy particles and quanta in astrophysics

    NASA Technical Reports Server (NTRS)

    Mcdonald, F. B. (editor); Fichtel, C. E.

    1974-01-01

    The various subdisciplines of high-energy astrophysics are surveyed in a series of articles which attempt to give an overall view of the subject as a whole by emphasizing the basic physics common to all fields in which high-energy particles and quanta play a role. Successive chapters cover cosmic ray experimental observations, the abundances of nuclei in the cosmic radiation, cosmic electrons, solar modulation, solar particles (observation, relationship to the sun acceleration, interplanetary medium), radio astronomy, galactic X-ray sources, the cosmic X-ray background, and gamma ray astronomy. Individual items are announced in this issue.

  17. Determination of alpha-particle track depths in CR39 detector from their cross-sections and replica heights

    Microsoft Academic Search

    F. M. F. Ng; K. Y. Luk; D. Nikezic; K. N. Yu

    2007-01-01

    A challenging task in the application of solid-state nuclear track detectors (SSNTDs) is the measurement of depths of the tracks. One approach involves breaking and polishing the side of SSNTDs to reveal the cross-sections of the tracks for direct measurements. Recently, surface profilometry was used to measure the heights of the replicas of alpha-particle tracks to give the track depths.

  18. Alpha-Particle-Driven Toroidal Alfv{acute e}n Eigenmodes in the Tokamak Fusion Test Reactor

    Microsoft Academic Search

    R. Nazikian; G. Fu; M. Bell; R. Bell; R. Budny; C. Bush; Z. Chang; Y. Chen; C. Cheng; D. Darrow; P. Efthimion; E. Fredrickson; B. Leblanc; R. Majeski; E. Mazzucato; S. Medley; J. Strachan; E. Synakowski; G. Taylor; S. Von Goeler; R. White; K. Wong; S. Zweben; S. Batha; F. Levinton; N. Gorelenkov; M. Petrov; D. Spong

    1997-01-01

    Alpha-particle-driven toroidal Alfv{acute e}n eigenmodes (TAEs) have been observed for the first time in deuterium-tritium (D-T) plasmas on the tokamak fusion test reactor (TFTR). These modes are observed 100â200ms following the end of neutral beam injection in plasmas with reduced central magnetic shear and elevated central safety factor [q(0)<1]. Mode activity is localized to the central region of the discharge

  19. Mechanism of Scintillation of Helium, Helium-Argon, and Helium-Neon Gas Mixtures Excited by Alpha Particles

    Microsoft Academic Search

    Shinzou Kubota; Tan Takahashi; Tadayoshi Doke

    1968-01-01

    An experimental investigation of the mechanism of scintillation of helium, helium-argon, and helium-neon mixtures excited by alpha particles has been performed. No detectable decrease in light yield was observed at pressures less than 3 atm when the applied electric field was increased in steps to Ep~1.0 V\\/cm Torr, where E is the electric field and p is the gas pressure.

  20. Evaluation of Melt-Grown, ZnO Single Crystals for Use as Alpha-Particle Detectors

    Microsoft Academic Search

    John S. Neal; Nancy C. Giles; Xiaocheng Yang; R. Andrew Wall; K. Burak Ucer; Richard T. Williams; Dariusz J. Wisniewski; Lynn A. Boatner; Varatharajan Rengarajan; Jeff E Nause; Bill Nemeth

    2008-01-01

    As part of an ongoing investigation of the scintillation properties of zinc-oxide-(ZnO)-based scintillators, several melt-grown, ZnO single crystals have been characterized using alpha-particle excitation, infrared reflectance, and room temperature photoluminescence. The crystals, grown by Cermet, Inc., using an oxygen-pressurized melt-growth process, were doped with Group 1 elements (Li), Group 2 elements (Mg), Group 3 elements (Ga, In) and lanthanides (Gd,

  1. NOTES ON MEASUREMENTS OF $alpha$PARTICLE ACTIVITY OF SOILS, FERTILIZERS, PLANTS AND ANIMALS

    Microsoft Academic Search

    1960-01-01

    A method is described for determining total alpha activity of a sample ; and at the same time determining the relative contributions of the uranium--; radium and thorium families. Results are reported from applications of the ; method in measurements of natural alpha radioactivity of samples of soils, ; fertilizers, plants, and animal materials. (C.H.);

  2. The Apollo Alpha Spectrometer.

    NASA Technical Reports Server (NTRS)

    Jagoda, N.; Kubierschky, K.; Frank, R.; Carroll, J.

    1973-01-01

    Located in the Science Instrument Module of Apollo 15 and 16, the Alpha Particle Spectrometer was designed to detect and measure the energy of alpha particles emitted by the radon isotopes and their daughter products. The spectrometer sensor consisted of an array of totally depleted silicon surface barrier detectors. Biased amplifier and linear gate techniques were utilized to reduce resolution degradation, thereby permitting the use of a single 512 channel PHA. Sensor identification and in-flight radioactive calibration were incorporated to enhance data reduction.

  3. Power Supplies for High Energy Particle Accelerators

    NASA Astrophysics Data System (ADS)

    Dey, Pranab Kumar

    2015-05-01

    The on-going research and the development projects with Large Hadron Collider at CERN, Geneva, Switzerland has generated enormous enthusiasm and interest amongst all to know about the ultimate findings on `God's Particle'. This paper has made an attempt to unfold the power supply requirements and the methodology adopted to provide the stringent demand of such high energy particle accelerators during the initial stages of the search for the ultimate particles. An attempt has also been made to highlight the present status on the requirement of power supplies in some high energy accelerators with a view that, precautionary measures can be drawn during design and development from earlier experience which will be of help for the proposed third generation synchrotron to be installed in India at a huge cost.

  4. Global modes and high-energy particles in ignited plasmas

    SciTech Connect

    Coppi, B.; Migliuolo, S. (Massachusetts Institute of Technology, Cambridge, Massachusetts 02319 (USA)); Pegoraro, F.; Porcelli, F. (JET Joint Undertaking, Abingdon, Oxon OX14 3EA, United Kingdom (GB))

    1990-05-01

    Fusion-produced alpha particles may spontaneously enhance the stability of an ignited plasma against {ital m}=1 internal modes. Stable values of the poloidal beta of the thermal plasma component significantly in excess of the ideal magnetohydrodynamic threshold can be attained, provided the region where the magnetic helical parameter {ital q} is below unity is not too wide and the ignition temperature is not too high. A comprehensive analysis of the different instability regimes is presented, with special attention to so-called fishbone oscillations'' and their influence on the ignition energy balance. The theoretical predictions compare favorably with sawtooth suppression experiments in the JET tokamak (Phys. Rev. Lett. {bold 60}, 2148 (1988)) with high-power, ion-cyclotron resonant frequency heating, where energetic ions in the MeV range are produced.

  5. Silicon Detectors for Low Energy Particle Detection

    E-print Network

    California at Berkeley, University of

    Silicon Detectors for Low Energy Particle Detection C.S. Tindall, N.P. Palaio, B.A. Ludewigt, S-7300 Abstract­ Silicon detectors with very thin entrance contacts have been fabricated for use in the IMPACT on the THEMIS mission. The silicon diode detectors were fabricated using a 200� thick phosphorous doped

  6. Zero Energy Bound States in Three--Particle Systems

    E-print Network

    Dmitry K. Gridnev

    2010-01-22

    Under certain restrictions on pair--potentials it is proved that the eigenvalues in the three--particle system are absorbed at zero energy threshold if there is no negative energy bound states and zero energy resonances in particle pairs.

  7. Microdosimetric characterization of energy-deposition patterns near the ends of alpha tracks 

    E-print Network

    Guetersloh, Stephen Brant

    2000-01-01

    MICRODOSIMETRIC CHARACTERIZATION OF ENERGY-DEPOSITION PATTERNS NEAR THE ENDS OF ALPHA TRACKS A Thesis by STEPHEN BRANT GUETERSLOH Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE May 2000 Major Subject: Health Physics MICRODOSIMETRIC CHARACTERIZATION OF ENERGY-DEPOSITION PATTERNS NEAR THE ENDS OF ALPHA TRACKS A Thesis by STEPHEN BRANT GUETERSLOH Submitted to Texas A&M University in partial...

  8. Design of a compact, low-energy-charged-particle-spectrometer for stellar nucleosynthesis experiments at OMEGA and the NIF

    NASA Astrophysics Data System (ADS)

    Armstrong, E.; Frenje, J.; Gatu Johnson, M.; Li, C. K.; Rinderknecht, H.; Rosenberg, M.; Seguin, F. H.; Sio, H.; Zylstra, A.; Petrasso, R. D.

    2014-10-01

    A compact ``Orange'' Spectrometer is being designed for measurements of alpha and proton spectra in the range of ~ 1-5 MeV, produced in low-yield 3He3He experiments at the OMEGA laser and at the National Ignition Facility (NIF). Particle ray-tracing through magnetic fields, modeled by COMSOL, were conducted with the code Python. The goal is to identify an optimal setup for a spectrometer to measure alpha particles at relatively low energies and at low yield. Ability to study the alpha particles in addition to the protons is essential for understanding the nuclear physics governing the final-state interactions between pairs of particles in the three-body final state. This work was supported in part by the U.S. DOE and NLUF.

  9. Improve the catalytic activity of {alpha}-Fe{sub 2}O{sub 3} particles in decomposition of ammonium perchlorate by coating amorphous carbon on their surface

    SciTech Connect

    Zhang Yifu [Engineering Research Center of Organosilicon Compound and Material, Ministry of Education of China, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (China); Liu Xinghai, E-mail: liuxh@whu.edu.c [School of Printing and Packaging, Wuhan University, Wuhan 430079 (China); Nie Jiaorong [Jianghe Chemical Factory of CSSG, Yuan'an 444200 (China); Yu Lei; Zhong Yalan [Engineering Research Center of Organosilicon Compound and Material, Ministry of Education of China, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (China); Huang Chi, E-mail: chihuang@whu.edu.c [Engineering Research Center of Organosilicon Compound and Material, Ministry of Education of China, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (China)

    2011-02-15

    Sphere- and pod-like {alpha}-Fe{sub 2}O{sub 3} particles have been selectively synthesized using NH{sub 3}.H{sub 2}O and NaOH solution to adjust the pH value of the designed synthetic system, respectively. The sphere-like {alpha}-Fe{sub 2}O{sub 3} particles with diameter about 25 nm on average were encapsulated into carbon shells to fabricate a novel core-shell composite ({alpha}-Fe{sub 2}O{sub 3}-C) through the coating experiments. The catalytic performance of the products on the thermal decomposition of ammonium perchlorate (AP) was investigated by thermal gravimetric analyzer (TG) and differential thermal analysis (DTA). The thermal decomposition temperatures of AP in the presence of pod-like {alpha}-Fe{sub 2}O{sub 3}, sphere-like {alpha}-Fe{sub 2}O{sub 3} and {alpha}-Fe{sub 2}O{sub 3}-C are reduced by 72, 81 and 109 {sup o}C, respectively, which show that {alpha}-Fe{sub 2}O{sub 3}-C core-shell composites have higher catalytic activity than that of {alpha}-Fe{sub 2}O{sub 3}. -- Graphical abstract: The catalytic performance of pod-like {alpha}-Fe{sub 2}O{sub 3}, sphere-like {alpha}-Fe{sub 2}O{sub 3} and {alpha}-Fe{sub 2}O{sub 3}-C on the thermal decomposition of ammonium perchlorate (AP). Display Omitted Research highlights: {yields} Sphere- and pod-like {alpha}-Fe{sub 2}O{sub 3} particles have been selectively synthesized using NH{sub 3}.H{sub 2}O and NaOH solution to adjust the pH value. {yields} A novel core-shell composite ({alpha}-Fe{sub 2}O{sub 3}-C core-shell structured composite) has been successfully synthesized using sphere-like {alpha}-Fe{sub 2}O{sub 3} particles as the cores and glucose as the source of carbon. {yields} The thermal decomposition temperatures of AP in the presence of pod-like {alpha}-Fe{sub 2}O{sub 3}, sphere-like {alpha}-Fe{sub 2}O{sub 3} and {alpha}-Fe{sub 2}O{sub 3}-C are reduced by 72, 81 and 109 {sup o}C, respectively, which shows that these materials have high catalytic activity.

  10. Selective gene amplification in mammalian cells after exposure to 60Co gamma rays, 241Am alpha particles, or uv light

    SciTech Connect

    Luecke-Huhle, C.P.; Pech, M.; Herrlich, P.

    1986-06-01

    Simian Virus 40 wild type (SV40)-transformed Chinese hamster embryo cells (Co631) contain about five viral copies integrated per cell genome. These SV40 sequences were used as endogenous indicator genes to study the response of mammalian cells to radiation at the gene level. An increase in copy number was detected by dispersed cell blotting and Southern analysis in combination with specific DNA hybridization. All types of radiation tested induce a 15- to 25-fold amplification of SV40 sequences without producing intact virus. The amplification is dose dependent and increases with time after irradiation: a maximum effect is observed at Day 3 after alpha particle or uv exposure and at Day 6 after gamma-ray exposure. A RBE of 6 can be calculated for alpha particles if amplification rates at Day 3 are compared. However, when the maximum effect is considered independent of time, no difference between different types of radiation is observed. Southern blots of genomic DNA show that not all integrated SV40 sequences are amplified upon radiation. Amplified sequences are found either in restriction fragments of relatively high molecular weight or in unit size fragments. SV40 amplification is selective in that the amplification of other genes, e.g., of alpha-actin, dhfr (dihydrofolate reductase), and of two oncogenes of the ras family (Kirsten ras and Harvey ras), was below detection level.

  11. Alpha-particle-induced luminescence of rare-earth-doped Y{sub 2}O{sub 3} nanophosphors

    SciTech Connect

    Cress, Cory D. [NanoPower Research Laboratories at the Rochester Institute of Technology, 85 Lomb Memorial Road, Rochester, NY 14623 (United States); Microsystems Engineering Program at the Rochester Institute of Technology, Rochester, NY 14623 (United States)], E-mail: cory_cress@hotmail.com; Redino, Christopher S. [NanoPower Research Laboratories at the Rochester Institute of Technology, 85 Lomb Memorial Road, Rochester, NY 14623 (United States)], E-mail: csr8932@rit.edu; Landi, Brian J. [NanoPower Research Laboratories at the Rochester Institute of Technology, 85 Lomb Memorial Road, Rochester, NY 14623 (United States)], E-mail: bjlsps@rit.edu; Raffaelle, Ryne P. [NanoPower Research Laboratories at the Rochester Institute of Technology, 85 Lomb Memorial Road, Rochester, NY 14623 (United States); Microsystems Engineering Program at the Rochester Institute of Technology, Rochester, NY 14623 (United States)], E-mail: rprsps@rit.edu

    2008-08-15

    The feasibility of utilizing Y{sub 2}O{sub 3}:Tb{sup 3+} and Y{sub 2}O{sub 3}:Eu{sup 3+} as radioluminescent nanophosphors under alpha-particle excitation is investigated. Materials synthesized by the urea homogeneous precipitation method were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). The XRD analysis of as-produced precipitates and nanophosphors fired at temperatures ranging from 950 to 1100 deg. C indicated the presence of highly crystalline cubic Y{sub 2}O{sub 3} with crystallite sizes of {approx}40 nm. SEM and TEM analysis revealed that particles with average diameters of {approx}200 nm and comprised of {approx}40 nm grains were obtained. High-resolution radioluminescence and photoluminescence spectra were used to investigate the unwanted radioluminescence saturation effects associated with the high ionization rate of alpha-particles. Additionally, the radioluminescence intensity as a function of rare-earth ion dopant concentration is investigated for these materials under alpha-particle excitation. The prospect for utilizing these materials as intermediate absorbers in indirect-conversion radioisotope batteries is discussed. - Graphical abstract: The photoluminescence and radioluminesce emission from rare-earth doped Y{sub 2}O{sub 3} nanophosphors are being investigated. Below is a representative image of the photoluminescence from Y{sub 2}O{sub 3}:Eu{sup 3+} (left) and Y{sub 2}O{sub 3}:Tb{sup 3+} (right) under UV-light excitation.

  12. COLLIMATING TOUSCHEK PARTICLES IN AN ENERGY RECOVERY LINEAR ACCELERATOR

    E-print Network

    Hoffstaetter, Georg

    COLLIMATING TOUSCHEK PARTICLES IN AN ENERGY RECOVERY LINEAR ACCELERATOR Michael P. Ehrlichman- tum would usually be inconsequential to the trajectory of the particles through the accelerator to longitudinal momentum significant to the trajec- tory of scattered particles through the accelerator

  13. Production of TNF-alpha and bone resorbing activity by macrophages in response to different types of bone cement particles.

    PubMed

    Ingham, E; Green, T R; Stone, M H; Kowalski, R; Watkins, N; Fisher, J

    2000-05-01

    We have compared the capacity of clinically relevant wear debris from seven different cement types to activate macrophages to produce TNF-alpha, IL-1beta, IL-6 and bone resorbing activity in vitro. The bone cements were: CMW 1 original (PMMA only); CMW 1RO (1 microm BaSO4; 9.2%); CMW copolymer bone cement 1 (10 microm BaSO4; 10%); CMW copolymer bone cement 2 (1 microm BaSO4; 10%); Palacos R (10 microm ZrO2; 15.6%); CMW Calcium phosphate cement 20% (10 microm tri-calcium phosphate; 20%) and CMW calcium phosphate cement 30% (10 microm tri-calcium phosphate; 30%). Cement debris was produced aseptically using a simple configuration wear test. The majority of particles were in the size range 0.1-0.5 microm for each cement type. The cement particles were co-cultured with the U937 macrophage cell line at ratios of 10 and 100 microm3 particle volumes to macrophage cell numbers for 24 h. At the 10:1 ratio the particles had no effect on the cells. At the 100:1 ratio, the major cytokine produced was TNF-alpha and there were no statistical differences between the different types of cement debris. The bone resorption activity of the co-culture supernatants was significantly greater than the control (U937 cells without particles) for particles of CMW 1RO, CMW copolymer bone cement 1, CMW copolymer bone cement 2 and Palacos R (P < 0.05, ANOVA). However there were no statistical differences between the levels of bone resoprtion evoked by these four cement types. The CMW1 original and CMW calcium phosphate containing cements failed to induce the macrophages to elaborate bone resorption activity at the 100:1 ratio. These data suggest that the addition of radio-opaque additives to bone cement may increase the capacity of the debris to induce osteolysis. PMID:10768752

  14. Do the various radiations present in BNCT act synergistically? Cell survival experiments in mixed alpha-particle and gamma-ray fields.

    PubMed

    Phoenix, Ben; Green, Stuart; Hill, Mark A; Jones, Bleddyn; Mill, Andrew; Stevens, David L

    2009-07-01

    In many radiotherapy situations patients are exposed to mixed field radiation. In particular in BNCT, as with all neutron beam exposures, a significant fraction of the dose is contributed by low LET gamma ray photons. The components of such a mixed field may show a synergistic interaction and produce a greater cell kill effect than would be anticipated from the independent action of the different radiation types. Such a synergy would have important implications for treatment planning and in the interpretation of clinical results. An irradiation setup has been created at the Medical Research Council in Harwell to allow simultaneous irradiation of cells by cobalt-60 gamma rays and plutonium-238 alpha-particles. The setup allows for variation of dose and dose rates for both sources along with variation of the alpha particle energy. A series of cell survival assays for this mixed field have been carried out using V79-4 cells and compared to exposures to the individual components of the field under identical conditions. In the experimental setup described no significant synergistic effect was observed. PMID:19376715

  15. Alpha-Particle Emitting 213Bi-Anti-EGFR Immunoconjugates Eradicate Tumor Cells Independent of Oxygenation

    PubMed Central

    Gaertner, Florian C.; Bruchertseifer, Frank; Morgenstern, Alfred; Essler, Markus; Senekowitsch-Schmidtke, Reingard

    2013-01-01

    Hypoxia is a central problem in tumor treatment because hypoxic cells are less sensitive to chemo- and radiotherapy than normoxic cells. Radioresistance of hypoxic tumor cells is due to reduced sensitivity towards low Linear Energy Transfer (LET) radiation. High LET ?-emitters are thought to eradicate tumor cells independent of cellular oxygenation. Therefore, the aim of this study was to demonstrate that cell-bound ?-particle emitting 213Bi immunoconjugates kill hypoxic and normoxic CAL33 tumor cells with identical efficiency. For that purpose CAL33 cells were incubated with 213Bi-anti-EGFR-MAb or irradiated with photons with a nominal energy of 6 MeV both under hypoxic and normoxic conditions. Oxygenation of cells was checked via the hypoxia-associated marker HIF-1?. Survival of cells was analysed using the clonogenic assay. Cell viability was monitored with the WST colorimetric assay. Results were evaluated statistically using a t-test and a Generalized Linear Mixed Model (GLMM). Survival and viability of CAL33 cells decreased both after incubation with increasing 213Bi-anti-EGFR-MAb activity concentrations (9.25 kBq/ml–1.48 MBq/ml) and irradiation with increasing doses of photons (0.5–12 Gy). Following photon irradiation survival and viability of normoxic cells were significantly lower than those of hypoxic cells at all doses analysed. In contrast, cell death induced by 213Bi-anti-EGFR-MAb turned out to be independent of cellular oxygenation. These results demonstrate that ?-particle emitting 213Bi-immunoconjugates eradicate hypoxic tumor cells as effective as normoxic cells. Therefore, 213Bi-radioimmunotherapy seems to be an appropriate strategy for treatment of hypoxic tumors. PMID:23724085

  16. Effect of composition and radiation on the Hertzian indentation behavior of nuclear waste glasses. [77-MeV alpha particles

    SciTech Connect

    Matzke, H.; Kahl, L.; Routbort, J.L.; Saidl, J.

    1983-01-01

    The Hertzian indentation technique has been used to determine the fracture toughness, K/sub Ic/ of two borosilicate glasses developed to contain high-level nuclear waste. For the product VG 98/12, adding selected groups of fission products leaves K/sub Ic/ unchanged, but addition of Pb lowers K/sub Ic/ by approx. 20%. Radiation with 77 MeV ..cap alpha..-particles to a dose of approx. 10/sup 15/ ..cap alpha../cm/sup 2/ increases K/sub Ic/ by approx. 75%. For the product SM 58 LW 11, the fracture toughness was measured on pieces taken from different parts of a large cylinder to investigate the effects of segregation phenomena and of partial crystallization and formation of small cristobalite inclusions which decrease K/sub Ic/ by approx. 25%.

  17. Fabrication, testing and simulation of a high spatial resolution alpha-particle imager based on ZnO nanowires in a polycarbonate nanoporous membrane

    NASA Astrophysics Data System (ADS)

    Taheri, Ali; Saramad, Shahyar; Ghalenoi, Samira; Setayeshi, Saeed

    2013-12-01

    A new architecture consisting of ZnO nanowires embedded in a polycarbonate nanoporous membrane was proposed, fabricated and simulated as a high spatial resolution alpha particle imager. The experimental and Geant4 simulation results showed that ZnO nanowires could act as scintillating fibers to prevent spread of the generated optical photons inside the imager. This property can be used to precisely determine alpha collision coordinates. An array of these nanowires can be also applied as a new high spatial resolution alpha particle imager.

  18. Measurement of the 187Re({\\alpha},n)190Ir reaction cross section at sub-Coulomb energies using the Cologne Clover Counting Setup

    E-print Network

    Scholz, P; Hennig, A; Netterdon, L; Becker, H W; Endres, J; Mayer, J; Giesen, U; Rogalla, D; Schlüter, F; Pickstone, S G; Zell, K O; Zilges, A

    2015-01-01

    Uncertainties in adopted models of particle+nucleus optical-model potentials directly influence the accuracy in the theoretical predictions of reaction rates as they are needed for reaction-network calculations in, for instance, {\\gamma}-process nucleosynthesis. The improvement of the {\\alpha}+nucleus optical-model potential is hampered by the lack of experimental data at astrophysically relevant energies especially for heavier nuclei. Measuring the Re187({\\alpha},n)Ir190 reaction cross section at sub-Coulomb energies extends the scarce experimental data available in this mass region and helps understanding the energy dependence of the imaginary part of the {\\alpha}+nucleus optical-model potential at low energies. Applying the activation method, after the irradiation of natural rhenium targets with {\\alpha}-particle energies of 12.4 to 14.1 MeV, the reaction yield and thus the reaction cross section were determined via {\\gamma}-ray spectroscopy by using the Cologne Clover Counting Setup and the method of {\\ga...

  19. High Energy Particles in the Solar Corona

    E-print Network

    Widom, A; Larsen, L

    2008-01-01

    Collective Ampere law interactions producing magnetic flux tubes piercing through sunspots into and then out of the solar corona allow for low energy nuclear reactions in a steady state and high energy particle reactions if a magnetic flux tube explodes in a violent event such as a solar flare. Filamentous flux tubes themselves are vortices of Ampere currents circulating around in a tornado fashion in a roughly cylindrical geometry. The magnetic field lines are parallel to and largely confined within the core of the vortex. The vortices may thereby be viewed as long current carrying coils surrounding magnetic flux and subject to inductive Faraday and Ampere laws. These laws set the energy scales of (i) low energy solar nuclear reactions which may regularly occur and (ii) high energy electro-weak interactions which occur when magnetic flux coils explode into violent episodic events such as solar flares or coronal mass ejections.

  20. Electron energy loss near supported particles

    NASA Astrophysics Data System (ADS)

    Zabala, N.; Rivacoba, A.

    1993-11-01

    A general expression for the energy-loss probability in scanning transmission electron microscopy valid for complex microstructures is presented in the framework of classical dielectric theory. Calculations are carried out for small particles half embedded in a planar interface. We used experimental data for the dielectric functions that characterize the media and we take into account the coupling among different multipolar terms. Resonances, present neither in the planar-interface nor in the isolated-sphere energy-loss spectra, are found. The results agree with many experimental results reported in the literature of the last few years. A different behavior between conducting and insulator supports is found. The effect of an oxide coating around the spherical particle is also discussed.

  1. Fabrication of high resolution n-type 4H-SiC epitaxial layer alpha particle detectors, defect characterization and electronic noise analysis

    NASA Astrophysics Data System (ADS)

    Zavalla, Kelvin J.; Chaudhuri, Sandeep K.; Mandal, Krishna C.

    2013-09-01

    In the present work high-resolution alpha particle detectors have been fabricated on high quality 20 ?m thick n-type 4H-SiC epitaxial layers. Schottky barrier detectors have been fabricated by depositing 10 nm thick nickel contacts on the Si face of the epilayers. The detectors were characterized using current-voltage (I-V), capacitance-voltage (CV), alpha spectroscopic measurements, and deep level transient spectroscopy (DLTS). I-V measurements revealed a barrier height of ~1.6 eV, diode ideality factor of 1.09, and leakage current of the order of 14 pA at an operating bias of 110 V. C-V measurements revealed low effective doping concentrations of 3.1 × 1014 cm-3 in the epilayers. A micropipe density lower than 1 cm-2 was evaluated in the epilayers. Pulse-height spectroscopy exhibited energy resolution as high as 0.37 % for 5.48 MeV alpha particles with a detector active area of 11 mm2. A diffusion length of ~13.2 ?m for holes has been determined in these detectors following a calculation based on a drift-diffusion model. Detailed electronic noise analysis in terms of equivalent noise charge (ENC) was carried out to study the effect of various noise components that contribute to the total electronic noise in the detection system. The noise analysis revealed that the white series noise due to the detector capacitance has substantial effect on the detector's overall performance. DLTS measurements have revealed the presence of at least four majority (electron) carrier trap levels that can act as recombination/generation or trapping centers.

  2. Development of a He- and He0 beam source for alpha particle measurement in a burning plasma.

    PubMed

    Tanaka, N; Sasao, M; Terai, K; Okamoto, A; Kitajima, S; Yamaoka, H; Wada, M

    2012-02-01

    Proof of principle experiments of neutral helium beam production for alpha particle diagnostics was carried out on a test stand. Negative helium ions were produced in the Li charge exchange cell, in which stable and long time operation was possible. He(-) beam was accelerated to 157 keV. Finally, He(0) beam was successfully produced after the flight in the drift-tube through the auto-electron-detachment process from He(-) to He(0). A neutral beam detector using a pyroelectric device was also developed to measure He(0) beam intensity. The metastable component in the neutral helium beam was found to be less than 2%. PMID:22380272

  3. 1.5D Quasilinear Model for Alpha Particle-TAE Interaction in ARIES ACT-I

    SciTech Connect

    K. Ghantous, N.N. Gorelenkov, C. Kessel, F. Poli

    2013-01-30

    We study the TAE interaction with alpha particle fusion products in ARIES ACT-I using the 1.5D quasilinear model. 1.5D uses linear analytic expressions for growth and damping rates of TAE modes evaluated using TRANSP pro les to calculates the relaxation of pressure pro les. NOVA- K simulations are conducted to validate the analytic dependancies of the rates, and to normalize their absolute value. The low dimensionality of the model permits calculating loss diagrams in large parameter spaces.

  4. PPPL3164 Preprint Date: January 1996, UC420 Alpha Particle Losses from Tokamak Fusion Test Reactor

    E-print Network

    Reactor Deuterium­Tritium Plasmas D. S. Darrow, S. J. Zweben, S. Batha*, R. V. Budny, C. E. Bush + , Z. A. Spong + , E. J. Strait # , G. Taylor, R. B. White, J. R. Wilson, K.­L. Wong, and M. C. Zarnstorff can have a significant influence on tokamak reactor viability, the loss of deuterium­tritium alpha

  5. Nickel-59 in Surface Layers of Lunar Basalt 74275: Implications for the Solar Alpha Particle Flux

    NASA Technical Reports Server (NTRS)

    Schnabel, C.; Xue, S.; Ma, P.; Herzog, G. F.; Fifield, K.; Cresswell, R. G.; diTada, M. L.; Hausladen, Paul; Reedy, R. C.

    2000-01-01

    By using AMS we have profiled 59 Ni/Ni ratios in lunar basalt 74275. Activities (dpm 59 Ni/[kg Fe]) range from 120 to 10 at depths (mg/cm 2) from about 30 to 650. Modeling results hint at higher solar alpha fluxes during the last about 0.5 My than during the last approximately 1 My.

  6. TF Ripple Loss of Alpha Particles from the ITER Interim Design: Simulation and Theory

    E-print Network

    the normalization of a simple model for stochastic ripple losses within the TRANSP code [6]. Collisions were found without collisional eects. Good agree- ment was found in comparing appropriately normalized TRANSP in the ITER database. TRANSP simulations of ITER also provided alpha source pro#12;les, before and after

  7. TF Ripple Loss of Alpha Particles from the ITER Interim Design: Simulation and Theory

    E-print Network

    the normalization of a simple model for stochastic ripple losses within the TRANSP code [6]. Collisions were found without collisional effects. Good agree­ ment was found in comparing appropriately normalized TRANSP database. TRANSP simulations of ITER also provided alpha source profiles, before and after sawtooth

  8. Effects of corotating interaction regions on Ulysses high energy particles

    SciTech Connect

    Droege, W.; Kunow, H.; Heber, B.; Mueller-Mellin, R.; Sierks, H.; Wibberenz, G. [Institut fuer Kernphysik, Universitaet Kiel, 24118 Kiel (Germany); Raviart, A.; Ducros, R.; Ferrando, P.; Rastoin, C. [CEA, DSM/DAPNIA/Service dAstrophysique, C.E. Saclay, 91191 Gif-sur-Yvette (France); Paizis, C. [Instituto Fisica Cosmica CNR, Universita di Milano, 20133 Milano (Italy); Gosling, J.T. [Los Alamos National Laboratory, Los Alamos New Mexico 87545 (United States)

    1996-07-01

    We investigate the intensity variation of low energy ({approximately}6{endash}23MeV/N) heliospheric ions and of galactic protons (250{endash}2200 MeV) observed by the Kiel Electron Telescope onboard the Ulysses spacecraft associated with Corotating Interaction Regions (CIR) from mid-1992 to end of June 1995. This period covers Ulysses{close_quote} transit to high southern latitudes, the south polar pass, return to the solar equator and ascent to the north pole up to 70{degree}. We find that the flux of high energy protons exhibits a periodicity of about 26 days with a relative intensity variation of 10{percent}. At latitudes below {approximately}50{degree} the recurrent variations of galactic protons are in coincidence with the passage of CIRs and enhancements of low energies protons and alpha particles which are accelerated at the shocks of the CIRs. The modulation of galactic protons is observed up to high southern latitudes, where the signatures of a CIR are no longer visible in plasma or magnetic field data. The periodicity does not depend on latitude and its phase apparently remains constant during Ulysses{close_quote} pass over the south pole as well as through the solar equator. {copyright} {ital 1996 American Institute of Physics.}

  9. Effects of corotating interaction regions on Ulysses high energy particles

    SciTech Connect

    Droege, W.; Kunow, H.; Heber, B.; Mueller-Mellin, R.; Sierks, H.; Wibberenz, G.; Raviart, A.; Ducros, R.; Ferrando, P.; Rastoin, C.; Paizis, C.; Gosling, J. T. [Institut fuer Kernphysik, Universitaet Kiel, 24118 Kiel (Germany); CEA, DSM/DAPNIA/Service d'Astrophysique, C.E. Saclay, 91191 Gif-sur-Yvette (France); Instituto Fisica Cosmica CNR, Universita di Milano, 20133 Milano (Italy); Los Alamos National Laboratory, Los Alamos New Mexico 87545 (United States)

    1996-07-20

    We investigate the intensity variation of low energy ({approx}6-23 MeV/N) heliospheric ions and of galactic protons (250-2200 MeV) observed by the Kiel Electron Telescope onboard the Ulysses spacecraft associated with Corotating Interaction Regions (CIR) from mid-1992 to end of June 1995. This period covers Ulysses' transit to high southern latitudes, the south polar pass, return to the solar equator and ascent to the north pole up to 70 deg. We find that the flux of high energy protons exhibits a periodicity of about 26 days with a relative intensity variation of 10%. At latitudes below {approx}50 deg. the recurrent variations of galactic protons are in coincidence with the passage of CIRs and enhancements of low energies protons and alpha particles which are accelerated at the shocks of the CIRs. The modulation of galactic protons is observed up to high southern latitudes, where the signatures of a CIR are no longer visible in plasma or magnetic field data. The periodicity does not depend on latitude and its phase apparently remains constant during Ulysses' pass over the south pole as well as through the solar equator.

  10. Method and apparatus for generating low energy nuclear particles

    DOEpatents

    Powell, James R. (Shoreham, NY); Reich, Morris (Flushing, NY); Ludewig, Hans (Brookhaven, NY); Todosow, Michael (Miller Place, NY)

    1999-02-09

    A particle accelerator (12) generates an input particle beam having an initial energy level above a threshold for generating secondary nuclear particles. A thin target (14) is rotated in the path of the input beam for undergoing nuclear reactions to generate the secondary particles and correspondingly decrease energy of the input beam to about the threshold. The target (14) produces low energy secondary particles and is effectively cooled by radiation and conduction. A neutron scatterer (44) and a neutron filter (42) are also used for preferentially degrading the secondary particles into a lower energy range if desired.

  11. Method and apparatus for generating low energy nuclear particles

    DOEpatents

    Powell, J.R.; Reich, M.; Ludewig, H.; Todosow, M.

    1999-02-09

    A particle accelerator generates an input particle beam having an initial energy level above a threshold for generating secondary nuclear particles. A thin target is rotated in the path of the input beam for undergoing nuclear reactions to generate the secondary particles and correspondingly decrease energy of the input beam to about the threshold. The target produces low energy secondary particles and is effectively cooled by radiation and conduction. A neutron scatterer and a neutron filter are also used for preferentially degrading the secondary particles into a lower energy range if desired. 18 figs.

  12. Gene amplification and microsatellite instability induced in tumorigenic human bronchial epithelial cells by alpha particles and heavy ions

    NASA Technical Reports Server (NTRS)

    Piao, C. Q.; Hei, T. K.; Hall, E. J. (Principal Investigator)

    2001-01-01

    Gene amplification and microsatellite alteration are useful markers of genomic instability in tumor and transformed cell lines. It has been suggested that genomic instability contributes to the progression of tumorigenesis by accumulating genetic changes. In this study, amplification of the carbamyl-P-synthetase, aspartate transcarbamylase, dihydro-orotase (CAD) gene in transformed and tumorigenic human bronchial epithelial (BEP2D) cells induced by either alpha particles or (56)Fe ions was assessed by measuring resistance to N-(phosphonacetyl)-l-aspartate (PALA). In addition, alterations of microsatellite loci located on chromosomes 3p and 18q were analyzed in a series of primary and secondary tumor cell lines generated in nude mice. The frequency of PALA-resistant colonies was 1-3 x 10(-3) in tumor cell lines, 5-8 x 10(-5) in transformed cells prior to inoculation into nude mice, and less than 10(-7) in control BEP2D cells. Microsatellite alterations were detected in all 11 tumor cell lines examined at the following loci: D18S34, D18S363, D18S877, D3S1038 and D3S1607. No significant difference in either PALA resistance or microsatellite instability was found in tumor cell lines that were induced by alpha particles compared to those induced by (56)Fe ions.

  13. Development of a strongly focusing high-intensity He{sup +} ion source for a confined alpha particle measurement at ITER

    SciTech Connect

    Kisaki, M.; Shinto, K.; Kobuchi, T.; Okamoto, A.; Kitajima, S.; Sasao, M.; Tsumori, K.; Nishiura, M.; Kaneko, O.; Matsuda, Y.; Wada, M.; Sakakita, H.; Kiyama, S.; Hirano, Y. [School of Engineering, Tohoku University, Sendai 980-0579 (Japan); National Institute for Fusion Science, Toki, Gifu 509-5292 (Japan); Department of Electronics, Doshisha University, Kyotanabe, Kyoto 610-0321 (Japan); National Institute of Advanced Industrial Science and Technology, Tsukuba 305-8568 (Japan)

    2008-02-15

    A strongly focusing high-intensity He{sup +} ion source has been designed and constructed as a beam source for a high-energy He{sup 0} beam probe system for diagnosis of fusion produced alpha particles in the thermonuclear fusion plasmas. The He{sup +} beam was extracted from the ion source at an acceleration voltage of 18-35 kV. Temperature distributions of the beam target were observed with an IR camera. The 1/e-holding beam profile half-width was about 15 mm at optimum perveance (Perv) of 0.03 (I{sub beam}=2.4 A). A beam current about 3 A was achieved at an acceleration voltage of 26.7 kV with an arc power of 10 kW (Perv=0.023)

  14. Incident-Energy Dependent Quenching of the Analyzing Power in Pre-Equilibrium Composite Particle Emission

    SciTech Connect

    Cowley, A. A. [Physics Department, Stellenbosch University, Private Bag X1, Matieland 7602 (South Africa); iThemba LABS, PO Box 722, Somerset West 7129 (South Africa); Dimitrova, S. S. [Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, 1784 Sofia (Bulgaria); Zyl, J. J. van [Physics Department, Stellenbosch University, Private Bag X1, Matieland 7602 (South Africa)

    2011-10-28

    The proton-induced pre-equilibrium process in the energy range of 100 to 160 MeV, which leads to emission of composite ejectiles such as {sup 3}He and {alpha}-particles, is discussed. New cross section and analyzing power measurements for the (p,{sup 3}He) reaction on {sup 93}Nb at an incident energy of 160 MeV are presented, and these are found to be in agreement with the prediction of a statistical multistep theoretical formulation. The observed quenching of the analyzing power is also reproduced well by the theory. The results are consistent with earlier work at lower incident energies and other nuclear species.

  15. Screening materials with the XIA UltraLo alpha particle counter at Southern Methodist University

    SciTech Connect

    Nakib, M. Z.; Cooley, J.; Kara, B.; Qiu, H.; Scorza, S. [Department of Physics, Southern Methodist University, Dallas, TX (United States)] [Department of Physics, Southern Methodist University, Dallas, TX (United States); Guiseppe, V. E. [Department of Physics, University of South Dakota, Vermillion, SD (United States)] [Department of Physics, University of South Dakota, Vermillion, SD (United States); Rielage, K. [Los Alamos National Laboratory, Los Alamos, NM (United States)] [Los Alamos National Laboratory, Los Alamos, NM (United States); Schnee, R. W. [Department of Physics, Syracuse University, Syracuse, NY (United States)] [Department of Physics, Syracuse University, Syracuse, NY (United States)

    2013-08-08

    Southern Methodist University houses one of five existing commercially available UltraLo 1800 production model alpha counters made by XIA LLC. The instrument has an electron drift chamber with a 707 cm{sup 2} or 1800 cm{sup 2} counting region which is determined by selecting the inner electrode size. The SMU team operating this device is part of the SuperCDMS screening working group, and uses the alpha counter to study the background rates from the decay of radon in materials used to construct the SuperCDMS experiment. We have studied four acrylic samples obtained from the MiniCLEAN direct dark matter search with the XIA instrument demonstrating its utility in low background experiments by investigating the plate-out of {sup 210}Pb and comparing the effectiveness of cleaning procedures in removing {sup 222}Rn progenies from the samples.

  16. Substate Populations and Nuclear Polarization Produced by Inelastic Alpha-Particle Scattering on Carbon12

    Microsoft Academic Search

    T. D. Hayward; F. H. Schmidt

    1970-01-01

    We have measured the normalized alpha-gamma angular correlation in the reaction plane for excitation of the 4.44-MeV, 2+ state of 12C at 22.750 MeV. These data yield the relative populations (am)2 of the three magnetic substates referred to the normal to the reaction plane. The ambiguity between (a+2)2 and (a-2)2 was resolved by coincidence measurements of the circular polarization of

  17. Charged particle rapidity distributions at relativistic energies

    E-print Network

    Lin, ZW; Pal, S.; Ko, Che Ming; Li, Ba; Zhang, B.

    2001-01-01

    Gaussian distribution in transverse momentum. Also, a suppression factor of 0.30 is used for strange quark-antiquark pair pro- duction relative to the light quark-antiquark pair production. Charged particle rapidity distribution Zi-wei Lin,1 Subrata... in the AMPT model by fitting the experimental data from central Pb1Pb collisions at center-of-mass energy of 17A GeV @20#. Specifically, to ?2001 The American Physical Society1 RAPID COMMUNICATIONS LIN, PAL, KO, LI, AND ZHANG PHYSICAL REVIEW C 64 011902~R...

  18. Alpha track analysis and fission track analysis for localizing actinide-bearing micro-particles in the Yenisey River bottom sediments

    Microsoft Academic Search

    I. E. Vlasova; St. N. Kalmykov; Yu. V. Konevnik; S. G. Simakin; I. S. Simakin; A. Yu. Anokhin; Yu. A. Sapozhnikov

    2008-01-01

    Distribution of actinides in bottom sediment and flood land soil cores collected from the Yenisey River near the Krasnoyarsk Mining and Chemical Combine (MCC) were analyzed. Actinide-bearing micro-particles were localized using alpha track analysis (ATA) and fission track analysis (FTA). Different types of radioactive micro-particles were found by analysis of the ratios of fission tracks to ?-tracks from single particles.

  19. Pulse-shape discrimination of scintillation from alpha and beta particles with liquid scintillator and Geiger-mode multipixel avalanche diodes

    Microsoft Academic Search

    I. Kreslo; I. Badhrees; S. Delaquis; A. Ereditato; S. Janos; M. Messina; U. Moser; B. Rossi; M. Zeller

    2011-01-01

    A successfull application of Geiger-mode multipixel avalanche diodes (GMAPDs) for pulse-shape discrimination in alpha-beta spectrometry using organic liquid scintillator is described in this paper. Efficient discrimination of alpha and beta components in the emission of radioactive isotopes is achieved for alpha energies above 0.3 MeV. The ultra-compact design of the scintillating detector helps to efficiently suppress cosmic-ray and ambient radiation

  20. Evaluation of internal alpha-particle radiation exposure and subsequent fertility among a cohort of women formerly employed in the radium dial industry.

    PubMed

    Schieve, L A; Davis, F; Roeske, J; Handler, A; Freels, S; Stinchcomb, T; Keane, A

    1997-02-01

    This study examined the effect of internal exposure to alpha-particle radiation on subsequent fertility among women employed in the radium dial industry prior to 1930, when appreciable amounts of radium were often ingested through the practice of pointing the paint brush with the lips. The analysis was limited to women for whom a radium body burden measurement had been obtained and who were married prior to age 45 (n = 603). Internal radiation dose to the ovary was calculated based on initial intakes of radium-226 and radium-228, average ovarian mass, number and energy of alpha particles emitted, fraction of energy absorbed within the ovary, effective retention integrals and estimated photon irradiation. Time between marriage and pregnancy, number of pregnancies and number of live births served as surrogates for fertility. Radiation appeared to have no effect on fertility at estimated cumulative ovarian dose equivalents below 5 Sv; above this dose, however, statistically significant declines in both number of pregnancies and live births were observed. These trends persisted after multivariable adjustment for potential confounding variables and after exclusion of subjects contributing a potential classification or selection bias to the study. Additionally, the high-dose group experienced fewer live births than would have been expected based on population rates. There were no differences in time to first pregnancy between high- and low-dose groups. These results are consistent with earlier studies of gamma-ray exposures and suggest that exposure to high doses of radiation from internally deposited radium reduces fertility rather than inducing sterility. PMID:9008216

  1. Evaluation of internal alpha-particle radiation exposure and subsequent fertility among a cohort of women formerly employed in the radium dial industry

    SciTech Connect

    Schieve, L.A.; Davis, F.; Freels, S. [Univ. of Illinois, Chicago, IL (United States)] [and others

    1997-02-01

    This study examined the effect of internal exposure to {alpha}-particle radiation on subsequent fertility among women employed in radium dial industry prior to 1930, when appreciable amounts of radium were often ingested through the practice of pointing the paint brush with the lips. The analysis was limited to women for whom a radium body burden measurement had been obtained and who were married prior to age 45 (n = 603). Internal radiation dose to the ovary was calculated based on initial intakes of radium-226 and radium-228, average ovarian mass, number and energy of {alpha} particles emitted, fraction of energy absorbed within the ovary, effective retention integrals and estimated photon irradiation. Time between marriage and pregnancy, number of pregnancies and number of live births served as surrogates for fertility. Radiation appeared to have no effect on fertility at estimated cumulative ovarian dose equivalents below 5 Sv; above this dose, however, statistically significant declines in both number of pregnancies and live births were observed. These trends persisted after multivariable adjustment for potential confounding variables and after exclusion of subjects contributing a potential classification or selection bias to the study. Additionally, the high-dose group experienced fewer live births than would have been expected based on population rates. There were no differences in time to first pregnancy between high- and low-dose groups. These results are consistent with earlier studies of {gamma}-ray exposures and suggest that exposure to high doses of radiation from internally deposited radium reduces fertility rather than inducing sterility. 42 refs., 5 tabs.

  2. Elastic alpha scattering experiments and the alpha-nucleus optical potential at low energies

    SciTech Connect

    Mohr, P., E-mail: mohr@atomki.mta.hu [Institute of Nuclear Research (ATOMKI), H-4001 Debrecen (Hungary); Diakonie-Klinikum, D-74523 Schwäbisch Hall (Germany)] [Germany; Kiss, G.G.; Fülöp, Zs. [Institute of Nuclear Research (ATOMKI), H-4001 Debrecen (Hungary)] [Institute of Nuclear Research (ATOMKI), H-4001 Debrecen (Hungary); Galaviz, D. [Centro de Física Nuclear, University of Lisbon, P-1649-003 Lisbon (Portugal)] [Centro de Física Nuclear, University of Lisbon, P-1649-003 Lisbon (Portugal); Gyürky, Gy.; Somorjai, E. [Institute of Nuclear Research (ATOMKI), H-4001 Debrecen (Hungary)] [Institute of Nuclear Research (ATOMKI), H-4001 Debrecen (Hungary)

    2013-11-15

    High precision angular distribution data of (?,?) elastic scattering are presented for the nuclei {sup 89}Y, {sup 92}Mo, {sup 106,110,116}Cd, {sup 112,124}Sn, and {sup 144}Sm at energies around the Coulomb barrier. Such data with small experimental uncertainties over the full angular range (20–170°) are the indispensable prerequisite for the extraction of local optical potentials and for the determination of the total reaction cross section ?{sub reac}. A systematic fitting procedure was applied to the experimental scattering data presented to obtain comprehensive local potential parameter sets that are composed of a real folding potential and an imaginary potential of Woods–Saxon surface type. The potential parameters obtained were used in turn to construct a new systematic ?-nucleus potential with very few parameters. Although this new potential cannot reproduce the angular distributions with the same small deviations as the local potential, the new potential is able to predict the total reaction cross sections for all cases under study.

  3. Single particle tracking of alpha7 nicotinic AChR in hippocampal neurons reveals regulated confinement at glutamatergic and GABAergic perisynaptic sites.

    PubMed

    Bürli, Thomas; Baer, Kristin; Ewers, Helge; Sidler, Corinne; Fuhrer, Christian; Fritschy, Jean-Marc

    2010-01-01

    Alpha7 neuronal nicotinic acetylcholine receptors (alpha7-nAChR) form Ca(2+)-permeable homopentameric channels modulating cortical network activity and cognitive processing. They are located pre- and postsynaptically and are highly abundant in hippocampal GABAergic interneurons. It is unclear how alpha7-nAChRs are positioned in specific membrane microdomains, particularly in cultured neurons which are devoid of cholinergic synapses. To address this issue, we monitored by single particle tracking the lateral mobility of individual alpha7-nAChRs labeled with alpha-bungarotoxin linked to quantum dots in live rat cultured hippocampal interneurons. Quantitative analysis revealed different modes of lateral diffusion of alpha7-nAChR dependent on their subcellular localization. Confined receptors were found in the immediate vicinity of glutamatergic and GABAergic postsynaptic densities, as well as in extrasynaptic clusters of alpha-bungarotoxin labeling on dendrites. alpha7-nAChRs avoided entering postsynaptic densities, but exhibited reduced mobility and long dwell times at perisynaptic locations, indicative of regulated confinement. Their diffusion coefficient was lower, on average, at glutamatergic than at GABAergic perisynaptic sites, suggesting differential, synapse-specific tethering mechanisms. Disruption of the cytoskeleton affected alpha7-nAChR mobility and cell surface expression, but not their ability to form clusters. Finally, using tetrodotoxin to silence network activity, as well as exposure to a selective alpha7-nAChR agonist or antagonist, we observed that alpha7-nAChRs cell surface dynamics is modulated by chronic changes in neuronal activity. Altogether, given their high Ca(2+)-permeability, our results suggest a possible role of alpha7-nAChR on interneurons for activating Ca(2+)-dependent signaling in the vicinity of GABAergic and glutamatergic synapses. PMID:20634896

  4. Confined energy distribution for charged particle beams

    DOEpatents

    Jason, Andrew J. (Los Alamos, NM); Blind, Barbara (Los Alamos, NM)

    1990-01-01

    A charged particle beam is formed to a relatively larger area beam which is well-contained and has a beam area which relatively uniformly deposits energy over a beam target. Linear optics receive an accelerator beam and output a first beam with a first waist defined by a relatively small size in a first dimension normal to a second dimension. Nonlinear optics, such as an octupole magnet, are located about the first waist and output a second beam having a phase-space distribution which folds the beam edges along the second dimension toward the beam core to develop a well-contained beam and a relatively uniform particle intensity across the beam core. The beam may then be expanded along the second dimension to form the uniform ribbon beam at a selected distance from the nonlinear optics. Alternately, the beam may be passed through a second set of nonlinear optics to fold the beam edges in the first dimension. The beam may then be uniformly expanded along the first and second dimensions to form a well-contained, two-dimensional beam for illuminating a two-dimensional target with a relatively uniform energy deposition.

  5. Approximate recalculation of the {alpha}(Z{alpha}){sup 5} contribution to the self-energy effect on hydrogenic states with a multipole expansion

    SciTech Connect

    Zamastil, J., E-mail: zamastil@karlov.mff.cuni.cz

    2013-01-15

    A contribution of virtual electron states with large wave numbers to the self-energy of an electron bound in the weak Coulomb field is analyzed in the context of the evaluation method suggested in the previous paper. The contribution is of the order {alpha}(Z{alpha}){sup 5}. The same value for this contribution is found here as the one found in the previous calculations using different evaluation methods. When we add the remaining terms of the order {alpha}(Z{alpha}){sup 5} to the calculation of the self-energy effect in hydrogen-like ions presented in the previous paper we find a very good agreement with numerical evaluations. The relative difference between present and numerical evaluations ranges from 2 parts in 10{sup 6} for Z=1 up to 6 parts in 10{sup 4} for Z=10. - Highlights: Black-Right-Pointing-Pointer The complete terms of the order {alpha}(Z{alpha}){sup 5} are identified. Black-Right-Pointing-Pointer The accuracy of the result for the ground state of the hydrogen is 2 ppm. Black-Right-Pointing-Pointer The separation into the low and high energy regions and their matching is avoided.

  6. I. Excluded Volume Effects in Ising Cluster Distributions and Nuclear Multifragmentation II. Multiple-Chance Effects in Alpha-Particle Evaporation

    SciTech Connect

    Breus, Dimitry E.

    2005-05-16

    In Part 1, geometric clusters of the Ising model are studied as possible model clusters for nuclear multifragmentation. These clusters may not be considered as non-interacting (ideal gas) due to excluded volume effect which predominantly is the artifact of the cluster's finite size. Interaction significantly complicates the use of clusters in the analysis of thermodynamic systems. Stillinger's theory is used as a basis for the analysis, which within the RFL (Reiss, Frisch, Lebowitz) fluid-of-spheres approximation produces a prediction for cluster concentrations well obeyed by geometric clusters of the Ising model. If thermodynamic condition of phase coexistence is met, these concentrations can be incorporated into a differential equation procedure of moderate complexity to elucidate the liquid-vapor phase diagram of the system with cluster interaction included. The drawback of increased complexity is outweighted by the reward of greater accuracy of the phase diagram, as it is demonstrated by the Ising model. A novel nuclear-cluster analysis procedure is developed by modifying Fisher's model to contain cluster interaction and employing the differential equation procedure to obtain thermodynamic variables. With this procedure applied to geometric clusters, the guidelines are developed to look for excluded volume effect in nuclear multifragmentation. In part 2, an explanation is offered for the recently observed oscillations in the energy spectra of {alpha}-particles emitted from hot compound nuclei. Contrary to what was previously expected, the oscillations are assumed to be caused by the multiple-chance nature of {alpha}-evaporation. In a semi-empirical fashion this assumption is successfully confirmed by a technique of two-spectra decomposition which treats experimental {alpha}-spectra has having contributions from at least two independent emitters. Building upon the success of the multiple-chance explanation of the oscillations, Moretto's single-chance evaporation theory is augmented to include multiple-chance emission and tested on experimental data to yield positive results.

  7. Detachment energies of spheroidal particles from fluid-fluid interfaces

    NASA Astrophysics Data System (ADS)

    Davies, Gary B.; Krüger, Timm; Coveney, Peter V.; Harting, Jens

    2014-10-01

    The energy required to detach a single particle from a fluid-fluid interface is an important parameter for designing certain soft materials, for example, emulsions stabilised by colloidal particles, colloidosomes designed for targeted drug delivery, and bio-sensors composed of magnetic particles adsorbed at interfaces. For a fixed particle volume, prolate and oblate spheroids attach more strongly to interfaces because they have larger particle-interface areas. Calculating the detachment energy of spheroids necessitates the difficult measurement of particle-liquid surface tensions, in contrast with spheres, where the contact angle suffices. We develop a simplified detachment energy model for spheroids which depends only on the particle aspect ratio and the height of the particle centre of mass above the fluid-fluid interface. We use lattice Boltzmann simulations to validate the model and provide quantitative evidence that the approach can be applied to simulate particle-stabilized emulsions, and highlight the experimental implications of this validation.

  8. Detachment Energies of Spheroidal Particles from Fluid-Fluid Interfaces

    E-print Network

    Gary B. Davies; Timm Krüger; Peter V. Coveney; Jens Harting

    2014-10-28

    The energy required to detach a single particle from a fluid-fluid interface is an important parameter for designing certain soft materials, for example, emulsions stabilised by colloidal particles, colloidosomes designed for targeted drug delivery, and bio-sensors composed of magnetic particles adsorbed at interfaces. For a fixed particle volume, prolate and oblate spheroids attach more strongly to interfaces because they have larger particle-interface areas. Calculating the detachment energy of spheroids necessitates the difficult measurement of particle-liquid surface tensions, in contrast with spheres, where the contact angle suffices. We develop a simplified detachment energy model for spheroids which depends only on the particle aspect ratio and the height of the particle centre of mass above the fluid-fluid interface. We use lattice Boltzmann simulations to validate the model and provide quantitative evidence that the approach can be applied to simulate particle-stabilized emulsions, and highlight the experimental implications of this validation.

  9. Redefining Relative Biological Effectiveness in the Context of the EQDX Formalism: Implications for Alpha-Particle Emitter Therapy

    PubMed Central

    Hobbs, Robert F.; Howell, Roger W.; Song, Hong; Baechler, Sébastien; Sgouros, George

    2014-01-01

    Alpha-particle radiopharmaceutical therapy (?RPT) is currently enjoying increasing attention as a viable alternative to chemotherapy for targeting of disseminated micrometastatic disease. In theory, ?RPT can be personalized through pre-therapeutic imaging and dosimetry. However, in practice, given the particularities of ?-particle emissions, a dosimetric methodology that accurately predicts the thresholds for organ toxicity has not been reported. This is in part due to the fact that the biological effects caused by ?-particle radiation differ markedly from the effects caused by traditional external beam (photon or electron) radiation or ?-particle emitting radiopharmaceuticals. The concept of relative biological effectiveness (RBE) is used to quantify the ratio of absorbed doses required to achieve a given biological response with alpha particles versus a reference radiation (typically a beta emitter or external beam radiation). However, as conventionally defined, the RBE varies as a function of absorbed dose and therefore a single RBE value is limited in its utility because it cannot be used to predict response over a wide range of absorbed doses. Therefore, efforts are underway to standardize bioeffect modeling for different fractionation schemes and dose rates for both nuclear medicine and external beam radiotherapy. Given the preponderant use of external beams of radiation compared to nuclear medicine in cancer therapy, the more clinically relevant quantity, the 2 Gy equieffective dose, EQD2(?/?), has recently been proposed by the ICRU. In concert with EQD2(?/?), we introduce a new, redefined RBE quantity, named RBE2(?/?), as the ratio of the two linear coefficients that characterize the ? particle absorbed dose-response curve and the low-LET megavoltage photon 2 Gy fraction equieffective dose-response curve. The theoretical framework for the proposed new formalism is presented along with its application to experimental data obtained from irradiation of a breast cancer cell line. Radiobiological parameters are obtained using the linear quadratic model to fit cell survival data for MDA-MB-231 human breast cancer cells that were irradiated with either ? particles or a single fraction of low-LET 137Cs ? rays. From these, the linear coefficient for both the biologically effective dose (BED) and the EQD2(?/?) response lines were derived for fractionated irradiation. The standard RBE calculation, using the traditional single fraction reference radiation, gave RBE values that ranged from 2.4 for a surviving fraction of 0.82–6.0 for a surviving fraction of 0.02, while the dose-independent RBE2(4.6) value was 4.5 for all surviving fraction values. Furthermore, bioeffect modeling with RBE2(?/?) and EQD2(?/?) demonstrated the capacity to predict the surviving fraction of cells irradiated with acute and fractionated low-LET radiation, ? particles and chronic exponentially decreasing dose rates of low-LET radiation. RBE2(?/?) is independent of absorbed dose for ?-particle emitters and it provides a more logical framework for data reporting and conversion to equieffective dose than the conventional dose-dependent definition of RBE. Moreover, it provides a much needed foundation for the ongoing development of an ?-particle dosimetry paradigm and will facilitate the use of tolerance dose data available from external beam radiation therapy, thereby helping to develop ?RPT as a single modality as well as for combination therapies. PMID:24502376

  10. Coincidence measurements between alpha particles and gamma rays in reactions induced by 85 and 155 MeV š˛C on š??Sm

    E-print Network

    Cala, Steven Edward

    1978-01-01

    COINCIDENCE MEASUREMENTS BETWEEN ALPHA PARTICLES AND GAMMA RAYS 12 154 IN REACTIONS INDUCED BY 85 AND 155 MEV C ON Sm A Thesis by STEVEN EDWARD CALA Submitted to the Graduate College of Texas A&M University in partial fulfillment... of the requirement for the degree of MASTER OF SCIENCE August 1978 Major Subject: Chemistry COINCIDENCE MEASUREMENTS BETWEEN ALPHA PARTICLES AND GAMMA RAYS 12 154 IN REACTIONS INDUCED BY 85 AND 155 MEV C ON Sm A Thesis by STEVEN EDWARD CALA Approved...

  11. Improving Alpha Spectrometry Energy Resolution by Ion Implantation with ICP-MS

    SciTech Connect

    Dion, Michael P.; Liezers, Martin; Farmer, Orville T.; Miller, Brian W.; Morley, Shannon M.; Barinaga, Charles J.; Eiden, Gregory C.

    2015-01-01

    We report results of a novel technique using an Inductively Coupled Plasma Mass Spectrometer (ICP-MS) as a method of source preparation for alpha spectrometry. This method produced thin, contaminant free 241Am samples which yielded extraordinary energy resolution which appear to be at the lower limit of the detection technology used in this research.

  12. Studies on the variation of the track etch rate along alpha particle trajectories in CR39

    Microsoft Academic Search

    B Dörschel; H Hartmann; K Kadner; P Rö?ler

    1995-01-01

    At the beginning of the etching process a constant track etch rate can be assumed. In deeper detector layers, however, the etch rate varies drastically along the particle trajectories. Consequently, the indirect determination of the track etch rate by measuring the etch pit diameters on the detector surface does not yield correct results. Therefore, a method for the direct measurement

  13. Use of incomplete energy recovery for the energy compression of large energy spread charged particle beams

    DOEpatents

    Douglas, David R. (Newport News, VA); Benson, Stephen V. (Yorktown, VA)

    2007-01-23

    A method of energy recovery for RF-base linear charged particle accelerators that allows energy recovery without large relative momentum spread of the particle beam involving first accelerating a waveform particle beam having a crest and a centroid with an injection energy E.sub.o with the centroid of the particle beam at a phase offset f.sub.o from the crest of the accelerating waveform to an energy E.sub.full and then recovering the beam energy centroid a phase f.sub.o+Df relative to the crest of the waveform particle beam such that (E.sub.full-E.sub.o)(1+cos(f.sub.o+Df))>dE/2 wherein dE=the full energy spread, dE/2=the full energy half spread and Df=the wave form phase distance.

  14. Evaluation of Melt-Grown, ZnO Single Crystals for Use as Alpha-Particle Detectors

    SciTech Connect

    Neal, John S [ORNL; Giles, N. C. [West Virginia University; Yang, Xiaocheng [West Virginia University; Wall, R. Andrew [Wake Forest University, Winston-Salem, NC; Ucer, Burak [Wake Forest University, Winston-Salem, NC; Williams, Richard T. [Wake Forest University, Winston-Salem, NC; Wisniewski, Dariusz J [ORNL; Boatner, Lynn A [ORNL; Rengarajan, Varatharajan [ORNL; Nause, Jeff E [ORNL; Nemeth, Bell [Cermet, Inc., Atlanta

    2008-01-01

    As part of an ongoing investigation of the scintillation properties of zinc-oxide-based scintillators, several melt-grown, ZnO single crystals have been characterized using -particle excitation, infrared reflectance, and room temperature photoluminescence. The crystals, grown by Cermet, Inc. using a pressurized melt growth process, were doped with Group 1 elements (Li), Group 2 elements (Mg), Group 3 elements (Ga, In) and Lanthanides (Gd, Er, Tm). The goals of these studies are to better understand the scintillation mechanisms associated with various members of the ZnO scintillator family and to then use this knowledge to improve the radiation detection capabilities of ZnO-based scintillators. One application for which ZnO is particularly well suited as a scintillator is as the associated particle detector in a deuterium-tritium (D-T) neutron generator. Application requirements include the exclusion of organic materials, outstanding timing resolution, and high radiation resistance. ZnO(Ga) and ZnO(In) have demonstrated fast (sub-nanosecond) decay times with relatively low light yields, and ZnO(Ga) has been used in a powder form as the associated particle detector for a D-T neutron generator. Four promising candidate materials, ZnO, ZnO:Ga, ZnO:In,Li, and ZnO:Er,Li, were identified in this study. These four samples demonstrated sub-nanosecond decay times and alpha particle excited luminescence comparable to BC-400 fast plastic scintillator. The ZnO:Mg,Ga, ZnO:Gd, and ZnO:Li samples demonstrated appreciable slow (microsecond) decay components that would be incompatible with high-counting-rate applications.

  15. High Energy K(alpha) Radiography Using High-intensity, Short-pulse Lasers

    SciTech Connect

    Park, H; Izumi, N; Key, M H; King, J A; Koch, J A; Landen, O L; Patel, P K; Price, D F; Remington, B A; Robey, H F; Snavely, R A; Tabak, M; Town, R J; Wickersham, J E; Stoeckl, C; Storm, M; Theobald, W; Chambers, D M; Eagelton, R; Goldsack, T; Clarke, R J; Heathcote, R; Giraldez, E; Nikroo, A; Steinman, D A; Stephens, R B; Zhang, B B

    2005-11-16

    We have performed experiments using Callisto, the Vulcan 100 TW and the Vulcan Petawatt high intensity lasers to understand the characteristics of high energy, K{alpha} x-ray sources and to implement workable radiography solutions at 20-100 keV. Our measurements show that the K{alpha} size from a simple foil target is larger than 60 {micro}m, far larger than the experiment resolution requirement. The total K{alpha} yield is independent of target thicknesses verifying that refluxing plays a major role in photon generation. Smaller radiating volumes emit brighter K{alpha} radiation. 1-D radiography experiments using small-edge-on foils resolved 10 {micro}m features with high contrast. We tested a variety of small volume 2-D point sources such as cones, wires, and embedded wires, measuring photon yields and comparing our measurements with predictions from hybrid-PIC LSP simulations. In addition to high-energy, high-resolution backlighters, future experiments will also need imaging detectors and diagnostic tools that are workable in the 20-100 keV energy range. An initial look at some of these detector issues is also presented.

  16. Radioimmunotherapy with alpha-emitting nuclides.

    PubMed

    McDevitt, M R; Sgouros, G; Finn, R D; Humm, J L; Jurcic, J G; Larson, S M; Scheinberg, D A

    1998-09-01

    This review discusses the application of alpha particle-emitting radionuclides in targeted radioimmunotherapy. It will outline the production and chemistry of astatine-211, bismuth-212, lead-212, actinium-225, bismuth-213, fermium-255, radium-223 and terbium-149, which at present are the most promising alpha-emitting isotopes available for human clinical use. The selective cytotoxicity offered by alpha particle-emitting radioimmunoconstructs is due to the high linear energy transfer and short particle path length of these radionuclides. Based upon the pharmacokinetics of alpha particle-emitting radioimmunoconstructs, both stochastic and conventional dosimetric methodology is discussed, as is the preclinical and initial clinical use of these radionuclides conjugated to monoclonal antibodies for the treatment of human neoplasia. PMID:9724387

  17. Neutrino Masses, Cosmological Parameters and Dark Energy from the Transmitted Flux in the Lyman-alpha Forest

    NASA Astrophysics Data System (ADS)

    Rossi, Graziano; Palanque-Delabrouille, N.; Yeche, C.; Borde, A.; Rich, J.; Viel, M.; Lesgourgues, J.

    2013-01-01

    The signature left in quasar spectra by the presence of neutral hydrogen in the Universe allows one to constrain the sum of the neutrino masses with unprecedented sensitivity, with respect to laboratory experiments. At the forefront of elementary particle physics and cosmology, this may also shed a new light on the neutrino mass hierarchy, and on the absolute mass scale of neutrinos. In addition, constrains on cosmological parameters and on the dark energy equation of state can be derived, from a joint parameter estimation. This however requires a detailed modeling of the line-of-sight power spectrum of the transmitted flux in the Lyman-alpha forest on scales ranging from a few to hundreds of Mpcs, which in turns demands for the inclusion and careful treatment of cosmological neutrinos. In particular, since massive neutrinos are known to significantly alter structure formation, one needs to quantify their free-streaming effect consistently. We develop here a new hydrodynamical code which incorporates cold dark matter, gas, and is also able to reproduce the impact of massive neutrinos on the one-dimensional power spectrum with a novel technique. In synergy with corresponding experimental work from state-of-the-art surveys such as BOSS, and with upcoming or future large-scale-structure probes (e.g. Planck, Euclid), this will allow one to constrain the sum of the neutrino massses and the main cosmological parameters with unprecedented statistical significance. The theoretical study presented here will be combined with topological techniques to investigate dark energy and the expansion history of the Universe directly from the Lyman-alpha transmitted flux. The method will be also relevant for BigBOSS, which is expected to produce Lyman-alpha forest data along ~600,000 distant QSOs, and the data will be used to study the line-of-sight one-dimensional fluctuations.

  18. TF-ripple loss of suprathermal alphas in ITER

    SciTech Connect

    Not Available

    1989-09-30

    TF-ripple loss of alphas below the critical energy is calculated for a noncircular ITER plasma. For 14 toroidal field (TF) coils, the particle loss was found to be about 6%. About 0.6% of the initial alpha energy (3.5 MeV) is lost. 26 refs., 9 figs., 3 tabs.

  19. Proton-nucleus optical potential in the alpha-particle model

    NASA Astrophysics Data System (ADS)

    Tan, Zhen-Qiang; Ruan, Wen-Ying

    1990-07-01

    In this paper, by using a phenomenological amplitude fitted with p- 4He elastic scattering data, and on the basis of the ?-particle model of the nucleus, a theoretical proton-nucleus optical potential is constructed. With this potential, the differential cross section, the polarization and the spin-rotation parameter for p- 12C elastic scattering are calculated at Tp = 200 and 398 MeV. The theoretical calculations are in good agreement with the experimental data.

  20. Alpha-particle formation and decay rates from Skyrme-HFB wave functions

    NASA Astrophysics Data System (ADS)

    Ward, D. E.; Carlsson, B. G.; Ĺberg, S.

    2014-05-01

    ? decay is treated microscopically, where the unstable mother nucleus and residual daughter nucleus are described using Hartree-Fock-Bogoliubov (HFB) wave functions, obtained with the Skyrme effective interaction. From these wave functions the amplitude for forming ? particles in the mother nucleus is computed. Two different Skyrme parametrizations with different pairing properties are compared, and we find good agreement with experiment for relative decay rates in both cases. The absolute values of the decay rates are underestimated.

  1. Targeting Aberrant DNA double strand break repair in triple negative breast cancer with alpha particle emitter radiolabeled anti-EGFR antibody

    PubMed Central

    Song, Hong; Hedayati, Mohammad; Hobbs, Robert F.; Shao, Chunbo; Bruchertseifer, Frank; Morgenstern, Alfred; DeWeese, Theodore L.; Sgouros, George

    2013-01-01

    The higher potential efficacy of alpha-particle radiopharmaceutical therapy lies in the 3 to 8-fold greater biological effectiveness (RBE) of alpha particles relative to photon or beta-particle radiation. This greater RBE, however, also applies to normal tissue, thereby reducing the potential advantage of high RBE. Since alpha particles typically cause DNA double strand breaks (DSBs), targeting tumors that are defective in DSB repair effectively increases the RBE, yielding a secondary, RBE-based differentiation between tumor and normal tissue that is complementary to conventional, receptor-mediated tumor targeting. In some triple negative breast cancers (TNBC, ER?/PR?/HER-2?), germline mutation in BRCA-1, a key gene in homologous recombination (HR) DSB repair, predisposes patients to early onset of breast cancer. These patients have few treatment options once the cancer has metastasized. In this study, we investigated the efficacy of alpha particle emitter, 213Bi labeled anti-EGFR antibody, Cetuximab, in BRCA-1 defective TNBC. 213Bi-Cetuximab was found to be significantly more effective in the BRCA-1 mutated TNBC cell line HCC1937 than BRCA-1 competent TNBC cell MDA-MB-231. siRNA knockdown of BRCA-1 or DNA-PKcs, a key gene in non-homologous end joining (NHEJ) DSB repair pathway, also sensitized TNBC cells to 213Bi-Cetuximab. Furthermore, the small molecule inhibitor of DNA-PKcs, NU7441, sensitized BRCA-1 competent TNBC cells to alpha particle radiation. Immunofluorescent staining of ?H2AX foci and comet assay confirmed that enhanced RBE is caused by impaired DSB repair. These data offer a novel strategy for enhancing conventional receptor-mediated targeting with an additional, potentially synergistic radiobiological targeting that could be applied to TNBC. PMID:23873849

  2. Targeting aberrant DNA double-strand break repair in triple-negative breast cancer with alpha-particle emitter radiolabeled anti-EGFR antibody.

    PubMed

    Song, Hong; Hedayati, Mohammad; Hobbs, Robert F; Shao, Chunbo; Bruchertseifer, Frank; Morgenstern, Alfred; Deweese, Theodore L; Sgouros, George

    2013-10-01

    The higher potential efficacy of alpha-particle radiopharmaceutical therapy lies in the 3- to 8-fold greater relative biological effectiveness (RBE) of alpha particles relative to photon or beta-particle radiation. This greater RBE, however, also applies to normal tissue, thereby reducing the potential advantage of high RBE. As alpha particles typically cause DNA double-strand breaks (DSB), targeting tumors that are defective in DSB repair effectively increases the RBE, yielding a secondary, RBE-based differentiation between tumor and normal tissue that is complementary to conventional, receptor-mediated tumor targeting. In some triple-negative breast cancers (TNBC; ER(-)/PR(-)/HER-2(-)), germline mutation in BRCA-1, a key gene in homologous recombination DSB repair, predisposes patients to early onset of breast cancer. These patients have few treatment options once the cancer has metastasized. In this study, we investigated the efficacy of alpha-particle emitter, (213)Bi-labeled anti-EGF receptor antibody, cetuximab, in BRCA-1-defective TNBC. (213)Bi-cetuximab was found to be significantly more effective in the BRCA-1-mutated TNBC cell line HCC1937 than BRCA-1-competent TNBC cell MDA-MB-231. siRNA knockdown of BRCA-1 or DNA-dependent protein kinase, catalytic subunit (DNA-PKcs), a key gene in non-homologous end-joining DSB repair pathway, also sensitized TNBC cells to (213)Bi-cetuximab. Furthermore, the small-molecule inhibitor of DNA-PKcs, NU7441, sensitized BRCA-1-competent TNBC cells to alpha-particle radiation. Immunofluorescent staining of ?-H2AX foci and comet assay confirmed that enhanced RBE is caused by impaired DSB repair. These data offer a novel strategy for enhancing conventional receptor-mediated targeting with an additional, potentially synergistic radiobiological targeting that could be applied to TNBC. PMID:23873849

  3. Energy distribution of produced particles in multiple particle production based on data of direct observation

    Microsoft Academic Search

    A. Ohsawa; E. H. Shibuya; M. Tamada

    2001-01-01

    The energy distribution of produced particles in multiple particle production is formulated empirically based on the data of direct observations by accelerator and cosmicray experiments at 1012 ˜ 1014 eV. The formulated distribution indicates violation of the Feynman scaling law, which was shown to be valid in low energy region of = 1015 eV by extrapolation. The distribution is also

  4. Use of the gas-filled-magnet technique for particle identification at low energies

    SciTech Connect

    Rehm, K.K.; Jiang, C.L.; Paul, M. [Hebrew Univ., Jerusalem (Israel)

    1995-08-01

    Reaction studies of interest to astrophysics with radioactive ion beams will be done mainly in inverse reaction kinematics, i.e., heavy particles bombarding a hydrogen target. The low energy of the outgoing heavy reaction products makes particle identification with respect to mass and nuclear charge a major challenge. For the planned {sup 18}F(p,{alpha}) experiment one expects five different types of particles in the outgoing channels: {sup 18}F and {sup 18}O (from elastic scattering of {sup 18}F and {sup 18}O on {sup 12}C), {sup 15}O and {sup 15}N (from the {sup 18}F and {sup 18}O induced (p,{alpha}) reactions) and {sup 12}C recoils from the polypropylene target. While mass determination can be achieved easily by time-of-flight (TOF) measurements, a determination of the nuclear charge presents a challenge, especially if the energy of the particles is below 500 keV/u. We studied the gas-filled magnet technique for Z-identification of light ions between Z = 6-9. In a gas-filled magnet the particles move with an average charge state {bar q} which in one parameterization is given by {bar q} = Z ln(avZ{sup {alpha}})/ln(bZ{sup {beta}}) where Z is the nuclear charge of the ions and v their velocity. Introducing into the expression for the magnetic rigidity B{rho} = mv/{bar q} results in a Z dependence of B{rho} which is valid to very low velocities. As a magnet we used the Enge split-pole spectrograph which was filled with nitrogen gas at a pressure of 0.5 Torr. The particles were detected in the focal plane with a 50 x 10 cm{sup 2} parallel-grid-avalanche counter which measured TOF and magnetic rigidity. The mass and Z separation was tested with {sup 13}C and {sup 18}O beams at energies of about 600 keV/u and recoil particles ranging from {sup 12}C to {sup 19}F. The Z-separation obtained at these energies was {triangle}Z/Z = 0.28 which is sufficient to separate individual elements for Z < 10.

  5. A Method of Measuring Hydrogen Isotopes in Surface Layers of Planetary Soils by Spectroscopy of Recoil Protons in Alpha Particle Elastic Scattering

    Microsoft Academic Search

    B. N. Korchuganov; G. G. Dol'nikov; M. V. Gerasimov; O. F. Prilutskii; R. Rider; G. Waenke; T. Economou

    2004-01-01

    A theoretical and experimental feasibility study of possible determination of the hydrogen and deuterium concentrations in the surface layers of planetary bodies is presented. The method under study is the recoil proton and deuteron spectrometry of forward scattering in the course of elastic interaction of alpha particles with the nuclei of hydrogen isotopes. The spectra of recoil protons and deuterons

  6. Observation of alpha particle loss from JET plasmas during ion cyclotron resonance frequency heating using a thin foil Faraday cup detector array

    Microsoft Academic Search

    D. S. Darrow; F. E. Cecil; V. Kiptily; K. Fullard; A. Horton; A. Murari; Jet Efda Contributors

    2010-01-01

    The loss of MeV alpha particles from JET plasmas has been measured with a set of thin foil Faraday cup detectors during third harmonic heating of helium neutral beam ions. Tail temperatures of ~2 MeV have been observed, with radial scrape off lengths of a few centimeters. Operational experience from this system indicates that such detectors are potentially feasible for

  7. Alpha particle and proton relative thermoluminescence efficiencies in LiF:Mg,Cu,P:is track structure theory up to the task?

    PubMed

    Horowitz, Y S; Siboni, D; Oster, L; Livingstone, J; Guatelli, S; Rosenfeld, A; Emfietzoglou, D; Bilski, P; Obryk, B

    2012-07-01

    Low-energy alpha particle and proton heavy charged particle (HCP) relative thermoluminescence (TL) efficiencies are calculated for the major dosimetric glow peak in LiF:Mg,Cu,P (MCP-N) in the framework of track structure theory (TST). The calculations employ previously published TRIPOS-E Monte Carlo track segment values of the radial dose in condensed phase LiF calculated at the Instituto National de Investigaciones Nucleares (Mexico) and experimentally measured normalised (60)Co gamma-induced TL dose-response functions, f(D), carried out at the Institute of Nuclear Physics (Poland). The motivation for the calculations is to test the validity of TST in a TL system in which f(D) is not supralinear (f(D) >1) and is not significantly dependent on photon energy contrary to the behaviour of the dose-response of composite peak 5 in the glow curve of LiF:Mg,Ti (TLD-100). The calculated HCP relative efficiencies in LiF:MCP-N are 23-87% lower than the experimentally measured values, indicating a weakness in the major premise of TST which exclusively relates HCP effects to the radiation action of the secondary electrons liberated by the HCP slowing down. However, an analysis of the uncertainties involved in the TST calculations and experiments (i.e. experimental measurement of f(D) at high levels of dose, sample light self-absorption and accuracy in the estimation of D(r), especially towards the end of the HCP track) indicate that these may be too large to enable a definite conclusion. More accurate estimation of sample light self-absorption, improved measurements of f(D) and full-track Monte Carlo calculations of D(r) incorporating improvements of the low-energy electron transport are indicated in order to reduce uncertainties and enable a final conclusion. PMID:22042968

  8. Optical appearance of alpha particle tracks in CR-39 SSNTD K.N. Yu *, H.H.W. Lee, A.W.T. Wong, Y.L. Law, S.F.L. Cheung, D. Nikezic, F.M.F. Ng

    E-print Network

    Yu, K.N.

    .40; 23.60 Keywords: CR-39 detector; Alpha particles; Tracks; Ray tracing; Gray level 1. Introduction OneOptical appearance of alpha particle tracks in CR-39 SSNTD K.N. Yu *, H.H.W. Lee, A.W.T. Wong, Y of the challenging tasks in the application of solid- state nuclear track detectors (SSNTDs) is the automation

  9. Inelastic Alpha Scattering Studies of Low-Energy Octupole Resonance

    E-print Network

    Moss, JM; Brown, D. R.; Youngblood, David H.; Rozsa, C. M.; Bronson, J. D.

    1978-01-01

    neutron separation evergy. It is likel a a su stamtial increase iri energy would resolve the LEEOH xnto numerous discrete states. Figure 2 shows a spectrum near th e expected 2048 40(. 8L = 16.5~ 2048 "Mo 1600 I4'xd 1024- 1024 800 04096 ?Zn 8L...=15 0 1600 IooMMo 8L= 13' 0 8192 4Srn 2048 ? 4096 0 2048 . 0 1024 Ag (Nat) 8?=IS 0 2000 148S 8?=16 l024 OOOO 0 1500 Y 8L=14 0 II6S e,=ls 750 0 2500 l54S~ 8L=16' 1250~~ 0 3000 0 leSn 8L=I6.5' 0 2048 Au 8 =15' 1500...

  10. beta-delayed alpha emission of N18: Broad Jpi=1- states in the C14 +alpha system

    Microsoft Academic Search

    L. Buchmann; J. D'Auria; M. Dombsky; U. Giesen; K. P. Jackson; P. McNeely; J. Powell; A. Volya

    2007-01-01

    The beta-delayed alpha-spectrum of N18 has been measured at the TISOL facility at TRIUMF resolving the structure of a broad alpha-particle distribution at alpha-energies of 1.5 5.5 MeV into several states that show a distinct interference pattern. R-matrix fits assuming a solely Jpi=1- partial wave confirm this finding. The extrapolated low energy part of this structure constitutes the natural parity

  11. Applications of 211At and 223Ra in Targeted Alpha-Particle Radiotherapy

    PubMed Central

    Vaidyanathan, Ganesan; Zalutsky, Michael R.

    2012-01-01

    Targeted radiotherapy using agents tagged with ?-emitting radionuclides is gaining traction with several clinical trials already undertaken or ongoing, and others in the advanced planning stage. The most commonly used ?-emitting radionuclides are 213Bi, 211At, 223Ra and 225Ac. While each one of these has pros and cons, it can be argued that 211At probably is the most versatile based on its half life, decay scheme and chemistry. On the other hand, for targeting bone metastases, 223Ra is the ideal radionuclide because simple cationic radium can be used for this purpose. In this review, we will discuss the recent developments taken place in the application of 211At-labeled radiopharmaceuticals and give an overview of the current status of 223Ra for targeted ?-particle radiotherapy. PMID:22202151

  12. Readout cross-talk for alpha-particle measurements in a pixelated sensor system

    NASA Astrophysics Data System (ADS)

    Norlin, B.; Reza, S.; Krapohl, D.; Fröjdh, E.; Thungström, G.

    2015-05-01

    Simulations in Medici are performed to quantify crosstalk and charge sharing in a hybrid pixelated silicon detector. Crosstalk and charge sharing degrades the spatial and spectral resolution of single photon processing X-ray imaging systems. For typical medical X-ray imaging applications, the process is dominated by charge sharing between the pixels in the sensor. For heavier particles each impact generates a large amount of charge and the simulation seems to over predict the charge collection efficiency. This indicates that some type of non modelled degradation of the charge transport efficiency exists, like the plasma effect where the plasma might shield the generated charges from the electric field and hence distorts the charge transport process. Based on the simulations it can be reasoned that saturation of the amplifiers in the Timepix system might generate crosstalk that increases the charge spread measured from ion impact on the sensor.

  13. Applications of 211At and 223Ra in targeted alpha-particle radiotherapy.

    PubMed

    Vaidyanathan, Ganesan; Zalutsky, Michael R

    2011-10-01

    Targeted radiotherapy using agents tagged with ?-emitting radionuclides is gaining traction with several clinical trials already undertaken or ongoing, and others in the advanced planning stage. The most commonly used ?-emitting radionuclides are 213Bi, 211At, 223Ra and 225Ac. While each one of these has pros and cons, it can be argued that 211At probably is the most versatile based on its half life, decay scheme and chemistry. On the other hand, for targeting bone metastases, 223Ra is the ideal radionuclide because simple cationic radium can be used for this purpose. In this review, we will discuss the recent developments taken place in the application of 211At-labeled radiopharmaceuticals and give an overview of the current status of 223Ra for targeted ?-particle radiotherapy. PMID:22202151

  14. Numerical evaluation of high energy particle effects in magnetohydrodynamics

    Microsoft Academic Search

    R. B. White; Y. Wu

    1994-01-01

    The interaction of high energy ions with magnetohydrodynamic modes is analyzed. A numerical code is developed which evaluates the contribution of the high energy particles to mode stability using orbit averaging of motion in either analytic or numerically generated equilibria through Hamiltonian guiding center equations. A dispersion relation is then used to evaluate the effect of the particles on the

  15. Zero Energy Bound States in Many--Particle Systems

    E-print Network

    Dmitry K. Gridnev

    2011-12-01

    It is proved that the eigenvalues in the N--particle system are absorbed at zero energy threshold, if none of the subsystems has a bound state with $E \\leq 0$ and none of the particle pairs has a zero energy resonance. The pair potentials are allowed to take both signs.

  16. Pulse-shape discrimination of scintillation from alpha and beta particles with liquid scintillator and Geiger-mode multipixel avalanche diodes

    E-print Network

    Kreslo, I; Delaquis, S; Ereditato, A; Janos, S; Messina, M; Moser, U; Rossi, B; Zeller, M

    2011-01-01

    A successfull application of Geiger-mode multipixel avalanche diodes (GMAPDs) for pulse-shape discrimination in alpha-beta spectrometry using organic liquid scintillator is described in this paper. Efficient discrimination of alpha and beta components in the emission of radioactive isotopes is achieved for alpha energies above 0.3 MeV. The ultra-compact design of the scintillating detector helps to efficiently suppress cosmic-ray and ambient radiation background. This approach allows construction of hand-held robust devices for monitoring of radioactive contamination in various environmental conditions.

  17. Pulse-shape discrimination of scintillation from alpha and beta particles with liquid scintillator and Geiger-mode multipixel avalanche diodes

    NASA Astrophysics Data System (ADS)

    Kreslo, I.; Badhrees, I.; Delaquis, S.; Ereditato, A.; Janos, S.; Messina, M.; Moser, U.; Rossi, B.; Zeller, M.

    2011-07-01

    A successfull application of Geiger-mode multipixel avalanche diodes (GMAPDs) for pulse-shape discrimination in alpha-beta spectrometry using organic liquid scintillator is described in this paper. Efficient discrimination of alpha and beta components in the emission of radioactive isotopes is achieved for alpha energies above 0.3 MeV. The ultra-compact design of the scintillating detector helps to efficiently suppress cosmic-ray and ambient radiation background. This approach allows construction of hand-held robust devices for monitoring of radioactive contamination in various environmental conditions.

  18. Determination of 239Pu and 240Pu isotope ratio for a nuclear bomb particle using X-ray spectrometry in conjunction with gamma-ray spectrometry and non-destructive alpha-particle spectrometry

    Microsoft Academic Search

    R. Pöllänen; K. Ruotsalainen; H. Toivonen

    2009-01-01

    A nuclear bomb particle from Thule containing Pu and U was analyzed using X-ray spectrometry in combination with gamma-ray spectrometry and non-destructive alpha-spectrometry. The main objective was to investigate the possibility to determine the 239Pu and 240Pu isotope ratios. Previously, X-ray spectrometry together with the above-mentioned methods has been successfully applied for radiochemically processed samples, but not for individual particles.

  19. Precision measurements of sigma_hadronic for alpha_eff(E) at ILC energies and (g-2)_mu

    E-print Network

    F. Jegerlehner

    2006-08-30

    A more precise determination of the effective fine structure constant alpha_eff(E) is mandatory for confronting data from future precision experiments with precise SM predictions. At a future e+e- collider like the ILC, as at LEP before, alpha_eff(E) plays the role the static zero momentum alpha=alpha_eff(0) plays in low energy physics. However, by going to the effective version of alpha one loses about a factor 2 times 10^2 at E=m_mu to 10^5 at E=M_Z in precision, such that for physics at the gauge boson mass scale and beyond alpha_eff(E) is the least known basic parameter, about a factor 20 less precise than the neutral gauge boson mass M_Z and by about a factor 60 less precise than the Fermi constant G_F. We discuss a strategy which should be able to reach a factor 10 improvement by appropriate efforts in performing dedicated measurements of sigma_hadronic in a wide energy range as well as efforts in theory and in particular improving the precision of the QCD parameters alpha_s, m_c and m_b. Projects at VEPP-2000 (Novosibirsk) and DANAE/KLOE-2 (Frascati) are particularly important for improving on alpha_eff(M_Z) as well as alpha_eff(m_mu). We present an up-to-date analysis including the recent data from KLOE, SND, CMD-2 and BABAR. The analysis based on e+e- data yields Delta alpha_had^(5)(M_Z) = 0.027593 +/- 0.000169 [alpha^-1(M_Z) = 128.938 +/- 0.023] and a_mu^had=(692.1 +/- 5.6) x 10^{-10}. We emphasize the very high improvement potential of the VEPP-2000 and DANAE/KLOE-2 projects.

  20. Monte Carlo particle-trajectory models for neutral cometary gases. I. Models and equations. II. The spatial morphology of the Lyman-alpha coma

    SciTech Connect

    Combi, M.R.; Smyth, W.H.

    1988-04-01

    The mathematical derivations of various methods employed in the Monte Carlo particle-trajectory model (MCPTM) are presented, and the application of the MCPTM to the calculation of the photochemical heating of the inner coma through the partial thermalization of cometary hydrogen atoms produced by the photodissociation of water is discussed. This model is then used to explain the observed morphology of the spatially extended Ly-alpha comas of comets. The rocket and Skylab images of the Ly-alpha coma of Comet Kohoutek are examined. 90 references.

  1. A Hot-ion-mode rf-driven Tokamak via Alpha Channeling

    E-print Network

    A Hot-ion-mode rf-driven Tokamak via Alpha Channeling Nathaniel Fisch Princeton Plasma Physics, 2005 #12;Hot-ion Mode RF-Driven Tokamak 1. RF energy channeled from alpha particles 2. Fusion reactivity can be doubled in hot ion mode. 3. RF current drive fueled by alpha channeling. 4. Ash removal

  2. Alpha Channeling in a Rotating Plasma

    SciTech Connect

    Abraham J. Fetterman and Nathaniel J. Fisch

    2008-09-23

    The wave-particle ?-channeling effect is generalized to include rotating plasma. Specifically, radio frequency waves can resonate with ? particles in a mirror machine with E × B rotation to diffuse the ? particles along constrained paths in phase space. Of major interest is that the ?-particle energy, in addition to amplifying the RF waves, can directly enhance the rotation energy which in turn provides additional plasma confinement in centrifugal fusion reactors. An ancillary benefit is the rapid removal of alpha particles, which increases the fusion reactivity.

  3. High energy particle experiment for the GEOTAIL mission: GEOTAIL HEP

    NASA Astrophysics Data System (ADS)

    Plans are presented for the High Energy Particle (HEP) experiment proposed for the Geotail mission as part of the International Solar Terrestrial Physics program. The HEP subsystem is designed to study the particle acceleration mechanism, energy flow, boundary dynamics, and the magnetic reconnection mechanism in the geotail region. Also, the experiment is planned to investigate the solar flare particle acceleration and propagation mechanism and the origin, lifetime, and propagation of cosmic ray heavy ions. The instruments on the HEP subsystem are described, including low energy particle detectors, burst detectors, and medium and high energy isotope telescopes. Also, consideration is given to the basic principles of the particle identification process, the electronics and data processing systems, key parameter information, telemetry data formats, calibration methods, and data analysis techniques.

  4. Feasibility of an alpha particle gas densimeter for stack sampling applications 

    E-print Network

    Johnson, Randall Mark

    1983-01-01

    10 "? ? ? CH 30 20 10 . 2 . 3 . 4 . 5 . 6 . 7 . 8 . 9 1 0 1 1 1 2 1 3 1 4 GAS Df NSITY (MG/CC) z ig. 16. Response curves for nitrogen at various lower level discriminator settings. 52 important a constant energy calibration... Xv o ~o 002 a T He ~ h ~ a --o CH4 + a o- p+ . 2 . 3 . 4 . 5 . 6 . 7 . 8 . 9 1. 0 1. 1 1. 2 1. 3 1. 4 GAS DENSITY (MG/CC) Pig. l0. Computed and experimental response for five gases. A bias in the model is apparent with these gases...

  5. Characteristics and mechanisms of the bystander response in monolayer cell cultures exposed to very low fluences of alpha particles

    NASA Astrophysics Data System (ADS)

    Little, John B.; Azzam, Edouard I.; de Toledo, Sonia M.; Nagasawa, Hatsumi

    2005-02-01

    When confluent cultures of mammalian cells are irradiated with very low fluences of alpha particles whereby only occasional cells receive any radiation exposure, genetic changes are observed in the non-irradiated ("bystander") cells. Upregulation of the p53 damage-response pathway as well as activation of proteins in the MAPK family occurred in bystander cells; p53 was phosphorylated on the serine 15 residue suggesting that the upregulation of p53 was a consequence of DNA damage. Damage signals were transmitted to bystander cells through gap junctions, as confirmed by the use of genetically manipulated cells including connexin43 knockouts. Expression of connexin43 was markedly enhanced by irradiation. A moderate bystander effect was observed for specific gene mutations and chromosomal aberrations. This effect was markedly enhanced in cells defective in the non-homologous end joining DNA repair pathway. Finally, an upregulation of oxidative metabolism occurred in bystander cells; the increased levels of reactive oxygen species appeared to be derived from flavine-containing oxidase enzymes. We hypothesize that genetic effects observed in non-irradiated bystander cells are a consequence of oxidative base damage; >90% of mutations in bystander cells were point mutations. When bystander cells cannot repair DNA double strand breaks, they become much more sensitive to the induction of chromosomal aberrations and mutations, the latter consisting primarily of deletion mutants. While we propose that the genetic effects occurring in bystander cells are a consequence of oxidative stress, the nature of the signal that initiates this process remains to be determined.

  6. Cell Cycle Checkpoint Proteins p21 and Hus1 Regulating Intercellular Signaling Induced By Alpha Particle Irradiation

    NASA Astrophysics Data System (ADS)

    Wu, Lijun; Zhao, Ye; Wang, Jun; Hang, Haiying

    In recent years, the attentions for radiation induced bystander effects (RIBE) have been paid on the intercellular signaling events connecting the irradiated and non-irradiated cells. p21 is a member of the Cip/Kip family and plays essential roles in cell cycle progression arrest after cellular irradiation. DNA damage checkpoint protein Hus1 is a member of the Rad9-Rad1-Hus1 complex and functions as scaffold at the damage sites to facilitate the activation of downstream effectors. Using the medium trasfer method and the cells of MEF, MEF (p21-/-), MEF (p21-/-Hus1-/-) as either medium donor or receptor cells, it was found that with 5cGy alpha particle irradiation, the bystander cells showed a significant induction of -H2AX for normal MEFs (pĄ0.05). However, the absence of p21 resulted in deficiency in inducing bystander effects. Further results indicated p21 affected the intercellular DNA damage signaling mainly through disrupting the production or release of the damage signals from irradiated cells. When Hus1 and p21 were both knocked out, an obvious induction of -H2AX recurred in bystander cells and the induction of -H2AX was GJIC (gap junction-mediated intercellular communication) dependent, indicating the interrelationship between p21 and Hus1 regulated the production and relay of DNA damage signals from irradiated cells to non-irradiated bystander cells.

  7. ``Bare'' single-particle energies in 56Ni

    Microsoft Academic Search

    L. Trache; A. Kolomiets; S. Shlomo; K. Heyde; H. Dejbakhsh; C. A. Gagliardi; R. E. Tribble; X. G. Zhou; V. E. Iacob; A. M. Oros

    1996-01-01

    The structure of the low-lying levels in the mirror nuclei 57Ni and 57Cu is described within the extended unified model. The problem of single-particle energies in 56Ni is treated in detail. ``Bare'' single-particle energies are extracted from existing experimental data for the energy levels in 57Ni and 57Cu by carefully considering the influence of the coupling to excitations of the

  8. Jet Physics at LEP and World Summary of $\\alpha_{s}$

    E-print Network

    Bethke, Siegfried

    1999-01-01

    Recent results on jet physics and tests of QCD from hadronic final states in $e^+e^-$ annihilation at PETRA and at LEP are reviewed, with special emphasis on hadronic event shapes, charged particle production rates, properties of quark and gluon jets and determinations of $\\alpha_s$. The data in the entire energy range from PETRA to LEP-2 are in broad agreement with the QCD predictions. The world summary of measurements of $\\alpha_s$ is updated and a detailed discussion of various methods to determine the overall error of uncertainties.

  9. Orientational energy of anisometric particles in liquid-crystalline suspensions.

    PubMed

    Burylov, S V; Zakhlevnykh, A N

    2013-07-01

    We obtain a general expression for the orientational energy of an individual anisometric particle suspended in uniform nematic liquid crystals when the main axis of the particle rotates with respect to the nematic director. We show that there is a qualitative and quantitative analogy between the internal and external problems for cylindrical volumes of nematic liquid crystals, and on this basis we obtain an estimate of the orientational energy of a particle of cylindrical (rodlike, needlelike, or ellipsoidal) shape. For an ensemble of such particles we propose a modified form of their orientational energy in the nematic matrix. This orientational energy has the usual second-order term, and additional fourth-order term in the scalar product of the nematic director and the vector which characterizes an average direction of the main axes of the particles. As an example we obtain the expression for the free energy density of ferronematics, i.e., colloidal suspensions of needlelike magnetic particles in nematic liquid crystals. Unlike previous models, the free energy density includes the proposed modified form of the particle orientational energy, and also a contribution describing the surface saddle-splay deformations of the liquid crystal matrix. PMID:23944478

  10. Low-altitude measurements of precipitating protons, alpha particles, and heavy ions during the geomagnetic storm on March 26-27, 1976

    NASA Technical Reports Server (NTRS)

    Scholer, M.; Hovestadt, D.; Hartmann, G.; Blake, J. B.; Fennell, J. F.; Gloeckler, G.

    1979-01-01

    During the geomagnetic storm of March 16-17, 1976, observations were made of precipitating protons, alpha particles, and heavy ions by two counter telescopes aboard the low-altitude S3-2 satellite. These observations are presented in this paper and their significance discussed. Briefly, a two-zone precipitation region is observed on the nightside, at L equals 2.7 and L equals 4.0 with an alpha/p ratio of about 0.008 in the low-latitude region and about 0.0009 at higher latitude at 0.4 MeV/necleon. The heavier ions, CNO nuclei, are seen in the low-latitude zone with a CNO/alpha ratio of about 0.056 at 0.25 MeV/nucleon.

  11. Ultra High Energy Cosmic Rays from Decaying Superheavy Particles

    E-print Network

    V. Berezinsky

    1998-01-08

    Decaying superheavy particles can be produced by Topological Defects or, in case they are quasi-stable, as relics from the early Universe. The decays of these particles can be the sources of observed Ultra High Energy Cosmic Rays ($E \\sim 10^{10} - 10^{12} GeV$). The Topological Defects as the UHE CR sources are critically reviewed and cosmic necklaces and monopole-antiminopole pairs are identified as most plausible sources. The relic superheavy particles are shown to be clustering in the halo and their decays produce UHE CR without GZK cutoff. The Lightest Supersymmetric Particles with Ultra High Energies are naturally produced in the cascades accompanying the decays of superheavy particles. These particles are discussed as UHE carriers in the Universe.

  12. EDITORIAL: Focus on High Energy Particle Astronomy FOCUS ON HIGH ENERGY PARTICLE ASTRONOMY

    NASA Astrophysics Data System (ADS)

    Ong, Rene A.; Covault, Corbin E.

    2009-05-01

    Astrophysics as a sub-discipline provides both unique opportunities and unique challenges relative to other fields of physics. On the one hand, the scope of astrophysics is literally universal, and we are free to examine the most interesting and exotic phenomena to be found anywhere. On the other hand, our access to the universe is limited to only those bits of information that nature happens to provide to us here on Earth. As astrophysicists, we have no direct control over our subject of study. We cannot conduct experiments to arrange stars in galaxies to our liking. We cannot initiate supernovas at specific times and places just to test our hypotheses. What we can do is to squeeze whatever information possible out of the the tiny particles that have traveled across vast distances to act as messengers to Earth from space. Fortunately, we are getting quite good at building a picture of the universe from the available astrophysical information. Nearly a decade into the millennium, scientists have deployed an impressive collection of sensitive observatories that are especially capable of unlocking the secrets of some of the most persistent astrophysical puzzles. In particular, in the fields of high-energy astrophysics corresponding to gamma-ray, cosmic ray and neutrino detection, we are moving to a new generation of experimental techniques that are dramatically more sensitive than prior efforts. These new instruments have two key properties: (1) increased collection area, which is critical for the low fluxes corresponding to high-energy messenger particles, and (2) precision directional reconstructions which allow observers to trace back the paths of these messengers to the originating astrophysical objects. Furthermore, as observational techniques mature, results from these complementary instruments provide an increasingly comprehensive picture of some of the more elusive astrophysical subjects. Each photon, cosmic ray, and neutrino result reported represents another clue to understanding the nature of high-energy objects both within and outside our galaxy. And yet, along with new understandings, we are also faced with new puzzles. Each of the papers in this focus issue presents the field of high-energy particle astronomy from the perspective of a given instrumental approach, corresponding to the current state-of-the-art for a particular class of messenger particle in a given energy range. For gamma-ray astronomy, we have a excellent report by R Johnson and R Mukherjee on results from space-borne telescopes, first from the Compton Gamma Ray Observatory and then from the recently commissioned Fermi Gamma-Ray Space Telescope. The detailed paper by J Hinton describes a wealth of results from several ground-based gamma-ray telescopes using the atmospheric Cherenokov technique. Gamma-ray results and the prospects from air-shower detectors which can provide all-sky monitoring are very well described in a paper by G Sinnis. Larger plans for the future of ground-based gamma-ray astronomy are summarized in a paper by F Krennrich (in preparation). We also include two papers for 'non-photon' particle detection, a summary of the exciting new results for cosmic ray physics by P Sommers and S Westerhoff and an article by K Hoffman describing the astrophysics and capabilities of truly remarkable, large-volume neutrino detectors. For both cosmic rays and neutrinos, the fields seem to be on the threshold of doing astronomy—that is, associating specific detected particles with particular astrophysical objects. Together, the fully operational space- and ground-based gamma-ray observatories and the new large-area experiments for cosmic ray and neutrino detection represent a new era in astronomy. We can be confident that the field of high-energy particle astronomy will continue to rapidly develop as more exciting results from these instruments are reported in the future. Focus on High Energy Particle Astronomy Contents Gamma ray astronomy with atmospheric Cherenkov telescopes: the future Frank Krennrich GeV telescopes: results and prospects

  13. The problem of low energy particle measurements in the magnetosphere

    NASA Technical Reports Server (NTRS)

    Whipple, E. C., Jr.

    1978-01-01

    The accurate measurement of low energy (less than 100 eV) particle properties in the magnetosphere has been difficult, partly because of the low density of such particles, but more particularly because of spacecraft interference effects. Some early examples of how these phenomena have affected particle measurements on an OGO spacecraft are presented. Data obtained with the UCSD particle detectors on ATS-6 are then presented showing how some of these difficulties have been partially overcome. Future measurements of low energy particles in the magnetosphere can be improved by: (1) improving the low energy resolution of detectors; (2) building electrostatically clean spacecraft; (3) controlling spacecraft potential; and (4) using auxiliary measurements, particularly wave data.

  14. Acceleration of low energy charged particles by gravitational waves

    E-print Network

    G. Voyatzis; L. Vlahos; S. Ichtiaroglou; D. Papadopoulos

    2005-12-07

    The acceleration of charged particles in the presence of a magnetic field and gravitational waves is under consideration. It is shown that the weak gravitational waves can cause the acceleration of low energy particles under appropriate conditions. Such conditions may be satisfied close to the source of the gravitational waves if the magnetized plasma is in a turbulent state.

  15. Non-destructive alpha-particle activation analysis of P, Cl, K and Ca in marine macro-alga samples using synthetic multielement reference material as comparative standard

    Microsoft Academic Search

    Y. Iwata; H. Naitoh; N. Suzuki

    1992-01-01

    A Synthetic Reference Material (SyRM) composed with accurately known amounts of 12 elements has been prepared. The elemental composition of the SyRM is closely similar to that of marine macro-algac sample. The elemental composition of the SyRM was regulated by the starting materials used for the synthesis. The SyRM was used as a comparative standard for non-destructive alpha-particle activation analysis

  16. Observation of alpha particle loss from JET plasmas during ion cyclotron resonance frequency heating using a thin foil Faraday cup detector array.

    PubMed

    Darrow, D S; Cecil, F E; Kiptily, V; Fullard, K; Horton, A; Murari, A

    2010-10-01

    The loss of MeV alpha particles from JET plasmas has been measured with a set of thin foil Faraday cup detectors during third harmonic heating of helium neutral beam ions. Tail temperatures of ? 2?MeV have been observed, with radial scrape off lengths of a few centimeters. Operational experience from this system indicates that such detectors are potentially feasible for future large tokamaks, but careful attention to screening rf and MHD induced noise is essential. PMID:21058457

  17. Observation of alpha particle loss from JET plasmas during ion cyclotron resonance frequency heating using a thin foil Faraday cup detector array

    SciTech Connect

    Darrow, D. S. [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543 (United States); Cecil, F. E. [Physics Department, Colorado School of Mines, Golden, Colorado 80401 (United States); Kiptily, V.; Fullard, K.; Horton, A. [Culham Centre for Fusion Energy, Euratom/CCFE Fusion Assoc., Abingdon, Oxon OX14 3DB (United Kingdom); Murari, A. [Consorzio RFX-Associazione EURATOM ENEA per la Fusione, I-35127 Padova (Italy); Collaboration: JET EFDA Contributors

    2010-10-15

    The loss of MeV alpha particles from JET plasmas has been measured with a set of thin foil Faraday cup detectors during third harmonic heating of helium neutral beam ions. Tail temperatures of {approx}2 MeV have been observed, with radial scrape off lengths of a few centimeters. Operational experience from this system indicates that such detectors are potentially feasible for future large tokamaks, but careful attention to screening rf and MHD induced noise is essential.

  18. Design and calibration of a two-channel low-noise heterodyne receiver for use in a CO/sub 2/ laser Thomson scattering alpha particle diagnostic

    SciTech Connect

    Bennett, C.A.; Richards, R.K.; Hutchinson, D.P.

    1988-03-01

    A dual channel low noise heterodyne receiver has been constructed as part of a development effort to build a carbon dioxide laser based Thomson scattering alpha particle diagnostic for a burning plasma experiment. The receiver employs two wide bandwidth (>1 GHz) HgCdTe photovoltaic mixers followed by low noise IF amplifiers. A noise equivalent power of less than 3.0 )times) 10/sup -20/ WHz has been demonstrated. Design details and calibration methods are described. 8 refs

  19. Particle Production in High-energy Heavy-ion Collisions

    E-print Network

    Xin-Nian Wang

    2001-11-29

    Particle production mechanisms in high-energy heavy-ion collisions are reviewed in connection with recent experimental data from RHIC. Implications on mini-jet production, parton saturation and jet quenching are discussed.

  20. Energy Transduction Inside Vesicles by Mineral Particles: Formation of NADH

    NASA Astrophysics Data System (ADS)

    Summers, D. P.; Noveron, J.; Basa, R. C. B.; Rodoni, D.

    2010-04-01

    Mineral semiconducting particles can be encapsulated inside vesicles, forming an energy transduction system that could have formed at any stage of the origin of life. This system can drive reactions such as the reduction of NAD+ to NADH.

  1. String Black Holes as Particle Accelerators to Arbitrarily High Energy

    E-print Network

    Parthapratim Pradhan

    2014-03-25

    We show that an extremal Gibbons-Maeda-Garfinkle-Horowitz-Strominger black hole may act as a particle accelerator with arbitrarily high energy when two uncharged particles falling freely from rest to infinity on the near horizon. We show that the center of mass energy of collision independent of the extreme fine tuning of the angular momentum of the colliding particles. We further show that the center of mass energy of collisions of particles at the ISCO ($r_{ISCO}$) or at the photon orbit ($r_{ph}$) or at the marginally bound circular orbit ($r_{mb}$) i.e. at $r \\equiv r_{ISCO}=r_{ph}=r_{mb}=2M$ could be arbitrarily large for the aforementioned spacetimes, which is different from Schwarzschild and Reissner-Nordstr{\\o}m spcetimes. For non-extremal GMGHS spacetimes the CM energy is finite and depends upon the asymptotic value of the dilation field ($\\phi_{0}$).

  2. 12.6 keV Kr K-alpha X-ray Source For High Energy Density Physics Experiments

    SciTech Connect

    Kugland, N; Constantin, C G; Niemann, C; Neumayer, P; Chung, H; Doppner, T; Kemp, A; Glenzer, S H; Girard, F

    2008-04-22

    A high contrast 12.6 keV Kr K{alpha} source has been demonstrated on the petawatt-class Titan laser facility. The contrast ratio (K{alpha} to continuum) is 65, with a competitive ultra short pulse laser to x-ray conversion efficiency of 10{sup -5}. Filtered shadowgraphy indicates that the Kr K{alpha} and K{beta} x-rays are emitted from a roughly 1 x 2 mm emission volume, making this source suitable for area backlighting and scattering. Spectral calculations indicate a typical bulk electron temperature of 50-70 eV (i.e. mean ionization state 13-16), based on the observed ratio of K{alpha} to K{beta}. Kr gas jets provide a debris-free high energy K{alpha} source for time-resolved diagnosis of dense matter.

  3. Extreme alpha-clustering in the 18O nucleus

    E-print Network

    E. D. Johnson; G. V. Rogachev; V. Z. Goldberg; S. Brown; D. Robson; A. M. Crisp; P. D. Cottle; C. Fu; J. Giles; B. W. Green; K. W. Kemper; K. Lee; B. T. Roeder; R. E. Tribble

    2009-09-30

    The structure of the 18O nucleus at excitation energies above the alpha decay threshold was studied using 14C+alpha resonance elastic scattering. A number of states with large alpha reduced widths have been observed, indicating that the alpha-cluster degree of freedom plays an important role in this N not equal Z nucleus. However, the alpha-cluster structure of this nucleus is very different from the relatively simple pattern of strong alpha-cluster quasi-rotational bands in the neighboring 16O and 20Ne nuclei. A 0+ state with an alpha reduced width exceeding the single particle limit was identified at an excitation energy of 9.9+/-0.3 MeV. We discuss evidence that states of this kind are common in light nuclei and give possible explanations of this feature.

  4. Entrainment of coarse particles in turbulent flows: An energy approach

    NASA Astrophysics Data System (ADS)

    Valyrakis, Manousos; Diplas, Panayiotis; Dancey, Clint L.

    2013-03-01

    The entrainment of coarse sediment particles under the action of fluctuating hydrodynamic forces is investigated from an energy perspective. It is demonstrated that the entrainment of a grain resting on the channel boundary is possible when the instantaneous flow power transferred to it exceeds a critical level. Its complete removal from the bed matrix occurs only if the impinging flow events supply sufficient mechanical energy. The energy-based criterion is formulated theoretically for entrainment of individual spherical particles in both saltation and rolling modes. Out of the wide range of flow events that can perform mechanical work on a coarse grain, only those with sufficient power and duration or equivalent energy density and characteristic length scale may accomplish its complete dislodgement. The instantaneous velocity upstream of a mobile particle is synchronously recorded with its position, enabling the identification of the flow events responsible for grain entrainment by rolling at near incipient motion flow conditions. For each of the entrainment events, the energy transfer coefficient defined as the ratio of the mechanical work performed on the particle to the mean energy of the flow event responsible for its dislodgement obtains values ranging from 0.04 to 0.10. At the examined low-mobility flow conditions, the majority (about 80%) of the energetic structures leading to complete particle entrainment have a characteristic length of about two to four particle diameters.

  5. High energy collision of two particles in wormhole spacetimes

    E-print Network

    Naoki Tsukamoto; Cosimo Bambi

    2015-04-06

    We study the collision of two particles in the Teo wormhole spacetime, in which the wormhole is stationary and axisymmetric. We show that a non-rotating Teo wormhole cannot be a particle accelerator, while a rotating Teo wormhole can be used to accelerate particles and create high energy collisions because of the deep effective potential of the colliding particles. The process is different from that in the vicinity of a near-extremal black hole, since here there is no event horizon. This is the first example of particle collision with high center-of-mass energy in a spacetime with no event horizon, no naked singularity, and not being extremal in a clear sense. The process can unlikely have direct implications for astrophysical observations, but it is interesting as a tool to investigate wormhole instabilities.

  6. Elemental Analysis of the Surface of Comet 67p/Churyumov-Gerasimenko with the Alpha Particle X-Ray Spectrometer APXS on the Rosetta Lander Philae: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Klingelhoefer, G.; Schmanke, D.; Girones-Lopez, J.; Brueckner, J.; d'Uston, C.; Economou, T.; Gellert, R.; Markovski, C.

    2014-12-01

    After a 10 years cruise the Rosetta probe has reached its final target, the comet 67P/Churyumov-Gerasimenko. The main objectives of the mission are to gain more knowledge of the composition, the origin and formation of comets and the solar system. After extensive remote exploration of the comet the lander Philae will be separated to land on the comet surface, starting immediately examining its landing site with its scientific payload. Part of this payload is the APXS (Alpha Particle X-Ray Spectrometer). It will measure in situ the chemical composition of the comet's surface and it's changes during the journey of the comet towards the sun. APXS is a combination of two spectrometers in one single instrument. It will irradiate the comet surface using Curium 244 sources, which are emitting alpha-particle and X-rays. In the alpha-mode the instrument uses alpha backscattering spectroscopy to detect lower Z elements like C, N and O and groups of elements with higher Z. In the X-ray mode alpha particle / X-ray induced X-ray spectroscopy (XRF) will allow the detection of most of the higher Z elements from Na up to Ni and above. Both modes will be always run in parallel allowing to determine lower and higher Z elements simultaneously. For 3 years the solar powered Rosetta probe had to pass a hibernation phase because of a long passage far away to the sun. After wakeup in January 2014 an extensive test phase of all instruments and subsystems has been performed, including the APXS. After landing on the comet an intense initial measurement phase of all instruments is planned, the First Science Sequence (FSS). It will be followed by a long term science phase (LTS). As long as possible APXS and the other instruments will continue to measure and monitor the changes and increasing activity of the comet during its journey towards the inner region of the solar system.The project is funded by the German Space Agency DLR under contracts 50 QP 0404 and 50 QP 0902. References: G. Klingelhöfer et al., The Rosetta Alpha Particle X-ray Spectrometer (APXS), Space Science Reviews, Vol.128 (2007) 383-396;

  7. Particle Spectra in Statistical Models with Energy and Momentum Conservation

    E-print Network

    V. V. Begun; M. Gazdzicki; M. I. Gorenstein

    2012-01-27

    Single particle momentum spectra are calculated within three micro-canonical statistical ensembles, namely, with conserved system energy, system momentum, as well as system energy and momentum. Deviations from the exponential spectrum of the grand canonical ensemble are quantified and discussed. For mean particle multiplicity and temperature, typical for p+p interactions at the LHC energies, the effect of the conservation laws extends to transverse momenta as low as about 3 GeV/c. The results may help to interpret spectra measured in nuclear collisions at high energies, in particular, their system size dependence.

  8. Particle energy cascade in the intergalactic medium

    NASA Astrophysics Data System (ADS)

    Valdés, M.; Evoli, C.; Ferrara, A.

    2010-05-01

    We study the development of high-energy (Ein <= 1 TeV) cascades produced by a primary electron of energy Ein injected into the intergalactic medium (IGM). To this aim we have developed the new code MEDEA (Monte Carlo Energy Deposition Analysis) which includes Bremsstrahlung and inverse Compton (IC) processes, along with H/He collisional ionizations and excitations, and electron-electron collisions. The cascade energy partition into heating, excitations and ionizations depends primarily not only on the IGM ionized fraction, xe, but also on redshift, z, due to IC on cosmic microwave background (CMB) photons. While Bremsstrahlung is unimportant under most conditions, IC becomes largely dominant at energies Ein >= 1 MeV. The main effect of IC at injection energies Ein <= 100 MeV is a significant boost of the fraction of energy converted into low-energy photons (h? < 10.2 eV) which do not further interact with the IGM. For energies Ein >= 1 GeV CMB photons are preferentially upscattered within the X-ray spectrum (h? > 104 eV) and can free stream to the observer. Complete tables of the fractional energy depositions as a function of redshift, Ein and ionized fraction are given. Our results can be used in many astrophysical contexts, with an obvious application related to the study of decaying/annihilating dark matter (DM) candidates in the high-z Universe.

  9. Energy momentum conservation effects on two-particle correlation functions

    E-print Network

    Nicolas Bock

    2011-01-27

    Two particle correlations are used to extract information about the characteristic size of the system in proton-proton and heavy ion collisions. The size of the system can be extracted from the Bose-Einstein quantum mechanical effect for identical particles. However there are also long range correlations that shift the baseline of the correlation function from the expected flat behavior. A possible source of these correlations is the conservation of energy and momentum, especially for small systems, where the energy available for particle production is limited. A new technique, first used by the STAR collaboration, of quantifying these long range correlations using energy-momentum conservation considerations is presented in this talk. Using Monte Carlo simulations of proton-proton collisions at 900 GeV, it is shown that the baseline of the two particle correlation function can be described using this technique.

  10. Analysis of nuclear materials by energy dispersive x-ray fluorescence and spectral effects of alpha decay

    SciTech Connect

    Worley, Christopher G [Los Alamos National Laboratory

    2009-01-01

    Energy dispersive X-ray fluorescence (EDXRF) spectra collected from alpha emitters are complicated by artifacts inherent to the alpha decay process, particularly when using portable instruments. For example, {sup 239}Pu EDXRF spectra exhibit a prominent uranium L X-ray emission peak series due to sample alpha decay rather than source-induced X-ray fluorescence. A portable EDXRF instrument was used to collect spectra from plutonium, americium, and a Pu-contaminated steel sample. The plutonium sample was also analyzed by wavelength dispersive XRF to demonstrate spectral differences observed when using these very different instruments.

  11. Factorization of number into prime numbers viewed as decay of particle into elementary particles conserving energy

    E-print Network

    Akio Sugamoto

    2008-10-24

    Number theory is considered, by proposing quantum mechanical models and string-like models at zero and finite temperatures, where the factorization of number into prime numbers is viewed as the decay of particle into elementary particles conserving energy. In these models, energy of a particle labeled by an integer $n$ is assumed or derived to being proportional to $\\ln n$. The one-loop vacuum amplitudes, the free energies and the partition functions at finite temperature of the string-like models are estimated and compared with the zeta functions. The $SL(2, {\\bf Z})$ modular symmetry, being manifest in the free energies is broken down to the additive symmetry of integers, ${\\bf Z}_{+}$, after interactions are turned on. In the dynamical model existing behind the zeta function, prepared are the fields labeled by prime numbers. On the other hand the fields in our models are labeled, not by prime numbers but by integers. Nevertheless, we can understand whether a number is prime or not prime by the decay rate, namely by the corresponding particle can decay or can not decay through interactions conserving energy. Among the models proposed, the supersymmetric string-like model has the merit of that the zero point energies are cancelled and the energy levels may be stable against radiative corrections.

  12. Astrophysical S-factor for {alpha}-Capture of {sup 113}In in the p-Process Energy Range

    SciTech Connect

    Yalcin, C. [Kocaeli University, Department of Physics, Umuttepe TR-41380, Kocaeli (Turkey); Institute of Nuclear Research (ATOMKI), H-4001 Debrecen, P.O. Box 51. (Hungary); Gueray, R. T.; Oezkan, N.; Kutlu, S. [Kocaeli University, Department of Physics, Umuttepe TR-41380, Kocaeli (Turkey); Gyuerky, Gy.; Farkas, J.; Kiss, G. G.; Fueloep, Zs.; Somorjai, E. [Institute of Nuclear Research (ATOMKI), H-4001 Debrecen, P.O. Box 51. (Hungary); Rauscher, T. [Universitaet Basel, CH-4056 Basel (Switzerland)

    2009-01-28

    The cross sections of {sup 113}In({alpha},{gamma}){sup 117}Sb and {sup 113}In({alpha},n){sup 116}Sb reactions have been measured using the activation method. The experiments were carried out at the ATOMKI cyclotron accelerator in the center of mass energy range from 8.7 to 13.7 MeV. Astrophysical S-factors have been calculated, and preliminary results are compared with statistical model predictions.

  13. An alpha scintillation spectrometer

    E-print Network

    Yates, Ralph Aaron

    1952-01-01

    . Uranium 1'hick Uranium sources were tested to determine if any differences would exist between the oulse height distribution oi' thick Uranium and Thorium sources. Sources were prepared by placing small pieces of Uranium nitrate, UO2 (NO3)2 6H20, on a... phosphor covered light-piper. The ten different energy alpha particles that were emitted from the Uranium were blended into a continuous distribution, there being no apparent difference between this and the thick Thorium distribution. The same was true...

  14. An alpha scintillation spectrometer 

    E-print Network

    Yates, Ralph Aaron

    1952-01-01

    . Uranium 1'hick Uranium sources were tested to determine if any differences would exist between the oulse height distribution oi' thick Uranium and Thorium sources. Sources were prepared by placing small pieces of Uranium nitrate, UO2 (NO3)2 6H20, on a... phosphor covered light-piper. The ten different energy alpha particles that were emitted from the Uranium were blended into a continuous distribution, there being no apparent difference between this and the thick Thorium distribution. The same was true...

  15. Alternative Discrete Energy Solutions to the Free Particle Dirac Equation

    E-print Network

    Thomas Edward Brennan

    2013-11-15

    The usual method of solving the free particle Dirac equation results in the so called continuum energy solutions. Here, we take a different approach and find a set of solutions with quantized energies which are proportional to the total angular momentum.

  16. Confinement of high-energy trapped particles in tokamaks

    SciTech Connect

    Goldston, R.J.; White, R.B.; Boozer, A.H.

    1981-08-31

    The banana orbits of high-energy trapped particles in tokamaks are found to diffuse rapidly in the radial direction if the toroidal ripple exceeds a low critical value. During this diffusion the energy, the magnetic moment, and the value of the magnetic field strength at the banana tips are conserved.

  17. Confinement of high energy trapped particles in tokamaks

    SciTech Connect

    Goldston, R.J.; White, R.B.; Boozer, A.H.

    1981-04-01

    The banana orbits of high energy trapped particles in tokamaks are found to diffuse rapidly in the radial direction if the toroidal ripple exceeds a low critical value. During this diffusion the energy, the magnetic moment, and the value of the magnetic field strength at the banana tips are conserved.

  18. Elementary particle physics and high energy phenomena

    SciTech Connect

    Barker, A.R.; Cumalat, J.P.; de Alwis, S.P.; DeGrand, T.A.; Ford, W.T.; Mahanthappa, K.T.; Nauenberg, U.; Rankin, P.; Smith, J.G.

    1992-06-01

    This report discusses the following research in high energy physics: the properties of the z neutral boson with the SLD detector; the research and development program for the SDC muon detector; the fixed-target k-decay experiments; the Rocky Mountain Consortium for HEP; high energy photoproduction of states containing heavy quarks; and electron-positron physics with the CLEO II and Mark II detectors. (LSP).

  19. (Medium energy particle physics): Annual progress report

    SciTech Connect

    Nefkens, B.M.K.

    1985-10-01

    Investigations currently carried out by the UCLA Particle Physics Research Group can be arranged into four programs: Pion-Nucleon Scattering; Tests of Charge Symmetry and Isospin Invariance; Light Nuclei (Strong Form Factors of /sup 3/H, /sup 3/He, /sup 4/He; Detailed Balance in pd /r reversible/ /gamma//sup 3/H; Interaction Dynamics); and Search for the Rare Decay /Mu//sup +/ /yields/ e/sup +/ + /gamma/ (MEGA). The general considerations which led to the choice of physics problems investigated by our group are given in the next section. We also outline the scope of the research being done which includes over a dozen experiments. The main body of this report details the research carried out in the past year, the status of various experiments, and new projects.

  20. Radium-223 dichloride bone-targeted alpha particle therapy for hormone-refractory breast cancer metastatic to bone

    PubMed Central

    2014-01-01

    Background Hormone-refractory breast cancer metastatic to bone is a clinically challenging disease associated with high morbidity, poor prognosis, and impaired quality of life owing to pain and skeletal-related events. In a preclinical study using a mouse model of breast cancer and bone metastases, Ra-223 dichloride was incorporated into bone matrix and inhibited proliferation of breast cancer cells and differentiation of osteoblasts and osteoclasts (all P values?alpha-particle therapy for the treatment of symptomatic bone metastases in patients with castration-resistant prostate cancer. On the basis of a strong preclinical rationale, we used Ra-223 dichloride to treat bone metastases in a patient with breast cancer. Results A 44-year-old white woman with metastatic breast cancer who was estrogen receptor–positive, BRCA1-negative, BRCA2-negative, PIK3CA mutation (p.His1047Arg) positive presented with diffuse bony metastases and bone pain. She had hormone refractory and chemotherapy refractory breast cancer. After Ra-223 therapy initiation her bone pain improved, with corresponding decrease in tumor markers and mixed response in 18F-FDG PET/CT and 18F-NaF bone PET/CT. The patient derived clinical benefit from therapy. Conclusion We have shown that Ra-223 dichloride can be safely administered in a patient with hormone-refractory bone metastasis from breast cancer at the US FDA–approved dose for prostate cancer. Furthermore, because the treatment did not cause any drop in hematologic parameters, it has the potential to be combined with other radiosensitizing therapies, which may include chemotherapy or targeted therapies. Given that Ra-223 dichloride is already commercially available, this case report may help future patients and provide a rationale for initiating clinical research in the use of Ra-223 dichloride to treat bone metastasis from breast cancer. A randomized clinical trial is needed to provide evidence of efficacy, safety, and good outcomes. PMID:25243101

  1. Numerical evaluation of high energy particle effects in magnetohydrodynamics

    SciTech Connect

    White, R.B.; Wu, Y.

    1994-03-01

    The interaction of high energy ions with magnetohydrodynamic modes is analyzed. A numerical code is developed which evaluates the contribution of the high energy particles to mode stability using orbit averaging of motion in either analytic or numerically generated equilibria through Hamiltonian guiding center equations. A dispersion relation is then used to evaluate the effect of the particles on the linear mode. Generic behavior of the solutions of the dispersion relation is discussed and dominant contributions of different components of the particle distribution function are identified. Numerical convergence of Monte-Carlo simulations is analyzed. The resulting code ORBIT provides an accurate means of comparing experimental results with the predictions of kinetic magnetohydrodynamics. The method can be extended to include self consistent modification of the particle orbits by the mode, and hence the full nonlinear dynamics of the coupled system.

  2. Using energy peaks to measure new particle masses

    NASA Astrophysics Data System (ADS)

    Agashe, Kaustubh; Franceschini, Roberto; Kim, Doojin

    2014-11-01

    We discussed in arXiv:1209.0772 that the laboratory frame distribution of the energy of a massless particle from a two-body decay at a hadron collider has a peak whose location is identical to the value of this daughter's (fixed) energy in the rest frame of the corresponding mother particle. For that result to hold we assumed that the mother is unpolarized and has a generic boost distribution in the laboratory frame. In this work we discuss how this observation can be applied for determination of masses of new particles, with out requiring a full reconstruction of their decay chains or information about the rest of the event. We focus on a two-step cascade decay of a massive particle that has one invisible particle in the final state: C ? Bb ? Aab, where C, B and A are new particles of which A is invisible and a, b are visible particles. Combining the measurements of the peaks of energy distributions of a and b with that of the edge in their invariant mass distribution, we demonstrate that it is in principle possible to determine separately all three masses of the new particles, in particular, without using any measurement of missing transverse momentum. Furthermore, we show how the use of the peaks in an inclusive energy distribution is generically less affected (as compared to other mass measurement strategies) by combinatorial issues. For some simplified, yet interesting, scenarios we find that these combinatorial issues are absent altogether. As an example of this general strategy, we study SUSY models where gluino decays to an invisible lightest neutralino via an on-shell bottom squark. Taking into account the dominant backgrounds, we show how the mass of the bottom squark, the gluino and (for some class of spectra) that of the neutralino can be determined using this technique.

  3. Charged particle multiplicity distributions in pp collisions at ISR energies

    Microsoft Academic Search

    W. Thomé; K. Eggert; K. Giboni; H. Lisken; P. Darriulat; P. Dittmann; M. Holder; K. T. McDonald; H. Albrecht; T. Modis; K. Tittel; H. Preissner; P. Allen; I. Derado; V. Eckardt; H.-J. Gebauer; R. Meinke; P. Seyboth; S. Uhlig

    1977-01-01

    We present the first direct measurements of charged-particle multiplicity distributions for pp collisions at ISR energies. The measurements are performed by means of a streamer chamber detector with large solid-angle coverage and excellent multitrack efficiency. Particle densities are observed to rise in the central region as sqrt(s) increases. The multiplicity distributions in this region deviate from a Poisson Law, thus

  4. The Compton-Getting effect for low energy particles

    NASA Technical Reports Server (NTRS)

    Ipavich, F. M.

    1974-01-01

    The traditional first-order Compton-Getting effect, which relates particle distributions as observed in two frames of reference moving with constant relative velocity, is inadequate for the description of low-energy particles (less than a few hundred keV/nucleon) in the solar system. An exact procedure is given for recovering both isotropic and anisotropic distributions in the solar wind frame from observations made in a spacecraft frame. The method is illustrated by analyzing a particle event observed by an experiment on IMP-7 on Oct. 31, 1972.

  5. The Compton-Getting effect for low energy particles

    NASA Technical Reports Server (NTRS)

    Ipavich, F. M.

    1974-01-01

    It was found that the traditional first-order Compton-Getting effect, which relates particle distributions as observed in two frames of reference moving with constant relative velocity, is inadequate for the description of low energy particles (less than a few hundred keV/nucleon) in the solar system. An exact procedure is given for recovering both isotropic and anisotropic distributions in the solar wind frame from observations made in a spacecraft frame. The method was illustrated by analyzing a particle event observed on IPM-7.

  6. HgI2 low energy beta particle detector

    NASA Technical Reports Server (NTRS)

    Shah, K. S.; Squillante, M. R.; Entine, G.

    1990-01-01

    An HgI2 device structure was designed and tested which allows HgI2 to be used to make low-energy beta-particle detectors. The devices detected tritium beta particles with an efficiency of about 25 percent. A protective encapsulant has been developed which should protect the devices for up to 20 years and will attenuate only a small fraction of the beta particles. It is noted that the devices hold significant promise to provide a practical alternative to liquid scintillation counters and gas flow-through proportional counters.

  7. Particle production vs energy M. Bonesini

    E-print Network

    McDonald, Kirk

    simulations ˇ Targetry for conventional neutrino beams ­ HARP for K2K, MINIBoone ­ NA56/SPY for WANF,CNGS, Nu energy beams (WANF, CNGS, NuMI, ...): NA20, NA56/SPY and coming soon MIPP, NA61/SHINE ˇ In addition a lot I will speak mainly of HARP (with an detour on NA56/SPY): see M.G. Catanesi's talk for the others

  8. Energy States of Colored Particle in a Chromomagnetic Field

    E-print Network

    Sh. Mamedov

    2006-11-24

    The unitary transformation, which diagonalizes squared Dirac equation in a constant chromomagnetic field is found. Applying this transformation, we find the eigenfunctions of diagonalized Hamiltonian, that describe the states with definite value of energy and call them energy states. It is pointed out that, the energy states are determined by the color interaction term of the particle with the background chromofield and this term is responsible for the splitting of the energy spectrum. We construct supercharge operators for the diagonal Hamiltonian, that ensure the superpartner property of the energy states.

  9. Charged particle rapidity distributions at relativistic energies 

    E-print Network

    Lin, ZW; Pal, S.; Ko, Che Ming; Li, Ba; Zhang, B.

    2001-01-01

    and the final-state interactions among hadrons. Other 0556-2813/2001/64~1!/011902~4!/$20.00 64 011902- s at relativistic energies ,1 Bao-An Li,2 and Bin Zhang2 M University, College Station, Texas 77843-3366 , P.O. Box 419, State University, Arkansas 72467... interactions. Such jet quenching is replaced in the AMPT model by explicitly taking into account parton-parton collisions via Zhang?s parton cascade ~ZPC! @13#. At present, only gluon elastic scatterings are included, so the partons do not suffer any...

  10. Charged-particle multiplicity at LHC energies

    ScienceCinema

    None

    2011-10-06

    The talk presents the measurement of the pseudorapidity density and the multiplicity distribution with ALICE at the achieved LHC energies of 0.9 and 2.36 TeV.An overview about multiplicity measurements prior to LHC is given and the related theoretical concepts are briefly discussed.The analysis procedure is presented and the systematic uncertainties are detailed. The applied acceptance corrections and the treatment of diffraction are discussed.The results are compared with model predictions. The validity of KNO scaling in restricted phase space regions is revisited. 

  11. DT RESULTS OF TFTR'S ALPHA COLLECTOR H. W. HERRMANN, S. J. ZWEBEN, D. S. DARROW, J. R. TIMBERLAKE

    E-print Network

    cause damage due to localized heating. Stud- ies of alpha particle loss mechanisms could also prove principle, ie. the implan- tation and subsequent trapping of alpha particles in nickel foils[5]. The primary reasons this detection technique was selected are: 1. to improve the energy resolution with respect

  12. DT RESULTS OF TFTR'S ALPHA COLLECTOR H. W. HERRMANN, S. J. ZWEBEN, D. S. DARROW, J. R. TIMBERLAKE

    E-print Network

    cause damage due to localized heating. Stud­ ies of alpha particle loss mechanisms could also prove principle, ie. the implan­ tation and subsequent trapping of alpha particles in nickel foils [5]. The primary reasons this detection technique was selected are: 1. to improve the energy resolution

  13. A mechanism of variation in the electrical properties of polycrystalline p-PbSe films as a result of irradiation with {alpha} particles

    SciTech Connect

    Salii, Ya. P. [Stefanik Carpathian-region National University (Ukraine)

    2006-02-15

    The effect of irradiation with 5.5-MeV {alpha} particles on the electrical properties of polycrystalline p-PbSe films is studied. It is found that the concentration (p) and mobility ({mu}) of charge carriers decreases as a result of irradiation. The linear dependence of p and {mu}{sup -1} on the square root of the integrated flux {phi}{sup 1/2} is accounted for on the assumption that interstitial atoms in both sublattices are captured by intrinsic extended defects (dislocations and grain boundaries)

  14. Collective relaxation, single particle motion and short range order in. cap alpha. '-NbD/sub x/: A quasielastic neutron scattering study

    SciTech Connect

    Hempelmann, R.; Richter, D.; Faux, D.A.; Ross, D.K.

    1988-01-01

    Applying both incoherent and coherent quasielastic neutron scattering we have studied simultaneously single particle motion, collective relaxation and short range order of deuterium in ..cap alpha..'-NbD/sub x/. A comparison with recent Monte Carlo simulations lead to a consistent description of all results in terms of strongly repulsive deuterium-deuterium interactions. Relating the independently determined tracer and chemical diffusion coefficients with the also measured structure factor we show experimentally that for lattice gases the de Gennes narrowing Ansatz needs to be modified by correlation factors. 18 refs., 3 figs., 1 tab.

  15. The use of alpha particle tagged neutrons for the inspection of objects on the sea floor for the presence of explosives

    NASA Astrophysics Data System (ADS)

    Valkovic, V.; Sudac, D.; Obhodas, J.; Eleon, C.; Perot, B.; Carasco, C.; Sannié, G.; Boudergui, K.; Kondrasovs, V.; Corre, G.; Normand, S.; Woo, R.; Bourbotte, J. M.

    2013-03-01

    A system using a neutron sensor installed within a Remotely Operated Vehicle (ROV) for underwater inspection has been developed. The system can inspect objects for the presence of threat materials, such as explosives and chemical agents, by using alpha particle tagged neutrons from a sealed tube d+t neutron generator to produce characteristic gamma rays within the interrogated object. Here we show that the measured gamma spectra for commonly found ammunition charged with TNT explosives are dominated by C, O and Fe peaks enabling the underwater determination of explosives inside an ammunition shell.

  16. Ultra-high energy cosmic rays from decaying relic particles.

    NASA Astrophysics Data System (ADS)

    Berezinsky, V.; Kachelriess, M.; Vilenkin, A.

    1999-01-01

    The authors report on a recent proposal that particles produced by the decays of ultraheavy and quasistable X-particles constitute the ultra high energy cosmic rays (UHECR). These X-particles are assumed to constitute a tiny fraction ?x of cold dark matter in the Universe, with ?x being the same in the halo of our Galaxy and in the intergalactic space. The UHECR fluxes produced at the decays of X-particles are dominated by photons and nucleons from the halo of our Galaxy. Thus they do not exihibit the Greisen-Zatsepin-Kuz'min cutoff and the cascade limit is relaxed. The authors discuss the spectrum of produced extensive air showers and a signal from the Virgo cluster as signatures of this model.

  17. The alpha magnetic spectrometer on the International Space Station

    Microsoft Academic Search

    B. Borgia

    2005-01-01

    The Alpha Magnetic Spectrometer (AMS) is a particle physics detector designed to measure charged cosmic ray spectra up to the TV region, with high-energy photon detection capability up to few hundred GeV. AMS is a superconducting spectrometer with large acceptance, long duration (at least three years for the magnet) and state of the art particle identification techniques. AMS will investigate

  18. Lyman alpha radiation in external galaxies

    NASA Technical Reports Server (NTRS)

    Neufeld, David A.; Mckee, Christopher F.

    1990-01-01

    The Ly alpha line of atomic hydrogen is often a luminous component of the radiation emitted by distant galaxies. Except for those galaxies which have a substantial central source of non-stellar ionizing radiation, most of the Ly alpha radiation emitted by galaxies is generated within regions of the interstellar medium which are photoionized by starlight. Conversely, much of the energy radiated by photoionized regions is carried by the Ly alpha line. Only hot, massive stars are capable of ionizing hydrogen in the interstellar medium which surrounds them, and because such stars are necessarily short-lived, Ly alpha emission traces regions of active star formation. Researchers argue that the strength of the Ly alpha emission observed from external galaxies may be used to estimate quantitatively the dust content of the emitting region, while the Ly alpha line profile is sensitive to the presence of shock waves. Interstellar dust particles and shock waves are intimately associated with the process of star formation in two senses. First, both dust particles and shock waves owe their existence to stellar activity; second, they may both serve as agents which facilitate the formation of stars, shocks by triggering gravitational instabilities in the interstellar gas that they compress, and dust by shielding star-forming molecular clouds from the ionizing and dissociative effects of external UV radiation. By using Ly alpha observations as a probe of the dust content in diffuse gas at high redshift, we might hope to learn about the earliest epochs of star formation.

  19. Analytical description of nonlinear particle transport in slab turbulence: High particle energies and stochastic acceleration

    SciTech Connect

    Shalchi, A. [Department of Physics and Astronomy, University of Manitoba, Winnipeg, Manitoba R3T 2N2 (Canada)

    2012-10-15

    Pitch-angle scattering, parallel spatial diffusion, and stochastic acceleration of cosmic rays are investigated analytically. Based on a second-order quasilinear theory, we derive analytical expressions for the aforementioned transport parameters for all possible magnetic field strengths and particle energies. This work complements previous work where only parallel diffusion for low energetic particles was considered. Furthermore, we compute the first time the momentum diffusion coefficient. It is also shown that the relation between the momentum diffusion coefficient and the parallel spatial diffusion coefficient is more complicated than assumed in previous work.

  20. The {sup 59}Co(n,{alpha}) reaction from threshold to 30 MeV

    SciTech Connect

    Lee, T.M.; Sterbenz, S.M.; Bateman, F.B. [and others

    1994-06-01

    Neutron-induced reactions that result in alpha-particle emission have been investigated for the target nucleus {sup 59}Co over the neutron energy range from threshold to 30 MeV with the spallation neutron source at WNR/LAMPF. Double-differential cross sections were measured at alpha-particle emission angles of 30, 60, 90 and 135{degree}. Integrated cross sections agree well with activation data below 14 MeV where only the {sup 59}Co(n,{alpha}){sup 56}Mn reaction contributes to alpha-particle emission. At higher energies, the integrated alpha-particle emission cross section exceeds the activation data. The results will be interpreted in terms of statistical and pre-compound reaction mechanisms. The sensitivity to nuclear level density parameters will be discussed.

  1. Schumann resonance parameter changes during high-energy particle precipitation

    NASA Astrophysics Data System (ADS)

    Schlegel, K.; Füllekrug, M.

    1999-05-01

    A systematic study of Schumann resonance parameters during high-energy particle precipitation events is presented. Protons and electrons with energies above 1 MeV ionize the upper boundary of the Earth-ionosphere cavity, leading to an increase of the resonance frequency and a decrease of the damping of the first Schumann resonance, as derived from measurements at Arrival Heights, Antarctica. The study uses the nine strongest solar proton events of the past solar cycle 22 and high-energy electrons emitted periodically from corotating interaction regions in the solar wind during 1994-1995. The variation of the Schumann resonance parameters is in qualitative agreement with current theories of Schumann resonances. The study also shows that high-energy particle precipitation is not the only relevant source affecting Schumann resonance parameters. The reported findings constitute a so far little-explored aspect of solar terrestrial relations.

  2. Alpha decay of the new isotope 174 Hg

    Microsoft Academic Search

    J. Uusitalo; M. Leino; R. G. Allatt; T. Enqvist; K. Eskola; P. T. Greenless; S. Hurskanen; A. Keenan; H. Kettunen; P. Kuusiniemi; R. D. Page; W. H. Trzaska

    1997-01-01

    Neutron deficient mercury isotopes were produced in the reaction 36Ar + 144Sm using bombarding energies of 180-230 MeV. Fusion products were separated in-flight from the primary beam using a gas-filled recoil separator. An alpha line with the alpha particle energy and half-life of (7069ᆟ) keV and (2.1+1.8т.7) ms, respectively, was assigned to the new mercury isotope 174Hg.

  3. Schumann resonance parameter changes during high-energy particle precipitation

    Microsoft Academic Search

    K. Schlegel; M. Füllekrug

    1999-01-01

    A systematic study of Schumann resonance parameters during high-energy particle precipitation events is presented. Protons and electrons with energies above 1 MeV ionize the upper boundary of the Earth-ionosphere cavity, leading to an increase of the resonance frequency and a decrease of the damping of the first Schumann resonance, as derived from measurements at Arrival Heights, Antarctica. The study uses

  4. A space motor using solar wind energy (magnetic particle sail)

    Microsoft Academic Search

    A. A. Bolonkin

    1992-01-01

    A space motor that uses solar wind for spacecraft thrust and electric energy production is described. Since the particle flow density is not great, protons and electrons are collected with a powerful magnet and their consequential reflection, absorption, or acceleration are used to create thrust. If used in conjuction with a superconductor circuit the motor can reach a thrust of

  5. Itep Investigation of Acoustic Phenomena from High Energy Particles

    NASA Astrophysics Data System (ADS)

    Demidov, V. S.; Demidova, E. V.; Gusev, K. E.; Lukyashin, V. E.; Lyashuk, V. I.; Novikov, E. G.; Rostovtsev, A. A.; Sokolov, A. Yu.; Albul, V. I.; Bychkov, V. B.; Krasnov, N. K.; Kurchanov, A. F.

    The mechanisms of sound wave generation from high energy protons and features of detector response are investigated in ITEP. The attention is attracted to the different possible mechanisms than the dominant thermoradiation excitation of sound. The search of sonic signals from cosmic particles, acoustic accelerator experiments and specific hardware - are the three vectors of ITEP acoustic activity.

  6. Energy flow or Particle flow The technique of "energy flow" for pedestrians.

    E-print Network

    Boyer, Edmond

    and the other to a muon pair. But most often hadronic jets with rather low energy tracks populate the detector it makes the low energy tracks curl around to end up in the end caps. This is even clearer in the figure 6Energy flow or Particle flow The technique of "energy flow" for pedestrians. Henri Videau LLR

  7. Activation cross sections of $\\alpha$-particle induced nuclear reactions on hafnium and deuteron induced nuclear reaction on tantalum: production of $^{178}$W/$^{178m}$Ta generator

    E-print Network

    Tárk'anyi, F; Ditrói, F; Hermanne, A; Ignatyuk, A V; Uddin, M S

    2014-01-01

    In the frame of a systematic study of charged particle production routes of medically relevant radionuclei, the excitation function for indirect production of $^{178m}$Ta through $^{nat}$Hf($\\alpha$,xn)$^{178}$W-$^{178m}$Ta nuclear reaction was measured for the first time up to 40 MeV. In parallel, the side reactions $^{nat}$Hf($\\alpha$,x)$^{179,177,176,175}$W, $^{183,182,178g,177,176,175}$Ta, $^{179m,177m,175}$Hf were also assessed. Stacked foil irradiation technique and $\\gamma$-ray spectrometry were used. New experimental cross section data for the $^{nat}$Ta(d,xn)$^{178}$W reaction are also reported up to 40 MeV. The measured excitation functions are compared with the results of the ALICE-IPPE, and EMPIRE nuclear reaction model codes and with the TALYS 1.4 based data in the TENDL-2013 library. The thick target yields were deduced and compared with yields of other charged particle ((p,4n), (d,5n) and ($^3$He,x)) production routes for $^{178}$W.

  8. Study of excited states in {sup 208}Pb by particle-{gamma} coincidences with the {sup 207}Pb(d,p){sup 208}Pb and {sup 209}Bi(t,{alpha}){sup 208}Pb reactions

    SciTech Connect

    Schramm, M.; Maier, K.H.; Rejmund, M.; Wood, L.D. [Hahn-Meitner-Institut Berlin, Glienicker Str. 100, D-14109 Berlin (Germany)] [Hahn-Meitner-Institut Berlin, Glienicker Str. 100, D-14109 Berlin (Germany); Roy, N.; Kuhnert, A.; Aprahamian, A.; Becker, J.; Brinkman, M.; Decman, D.J.; Henry, E.A.; Hoff, R.; Manatt, D.; Mann, L.G.; Meyer, R.A.; Stoeffl, W.; Struble, G.L.; Wang, T. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States)] [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States)

    1997-09-01

    Excited states in {sup 208}Pb have been studied by measuring {gamma} rays in time coincidence with reaction charged particles. {sup 208}Pb states were produced with both the {sup 207}Pb(d,p){sup 208}Pb and {sup 209}Bi(t,{alpha}){sup 208}Pb reactions. The energy resolution of the particle spectra of 100 keV allowed a rough determination of level excitation, which then was determined with high resolution from the coincident {gamma} decay measured in Ge detectors. Many new {gamma} transitions have been found and previously unresolved multiplets of states resolved. The data give spectroscopic factors for neutron transfer and proton pickup. Spins and parities of levels could be deduced from their {gamma} decays. A least squares fit of all {gamma} energies gave very precise (0.1 keV) level energies. All states predicted by the shell model below 4.6 MeV are now found and their spins determined unambiguously. {copyright} {ital 1997} {ital The American Physical Society}

  9. Positronium energy levels at order $m \\alpha^7$: vacuum polarization corrections in the two-photon-annihilation channel

    E-print Network

    Adkins, Gregory S; Salinger, M D; Wang, Ruihan

    2015-01-01

    We have calculated all contributions to the energy levels of parapositronium at order $m \\alpha^7$ coming from vacuum polarization corrections to processes involving virtual annihilation to two photons. This work is motivated by ongoing efforts to improve the experimental determination of the positronium ground-state hyperfine splitting.

  10. Energy-momentum balance in particle - domain wall perforating collision

    E-print Network

    D. V. Gal'tsov; E. Yu. Melkumova; P. A. Spirin

    2015-02-10

    We investigate the energy-momentum balance in the perforating collision of a point particle with an infinitely thin planar domain wall within the linearized gravity in arbitrary dimensions. Since the metric of the wall increases with distance, the wall and the particle are never free, and their energy-momentum balance involves not only the instantaneous kinetic momenta, but also the non-local contribution of gravitational stresses. However, careful analysis shows that the stresses can be unambiguously divided between the colliding objects leading to definition of the gravitationally dressed momenta. These take into account for gravity in the same way as the potential energy does in the non-relativistic theory, but our treatment is fully relativistic. Another unusual feature of our problem is the non-vanishing flux of the total energy-momentum tensor through the lateral surface of the world tube. In this case the zero divergence of the energy-momentum tensor does not imply conservation of the total momentum defined as the integral over the space-like section of the tube. But one can still define the conservation low infinitesimally, passing to time derivatives of the momenta. Using this definition we establish the momentum balance in terms of the dressed particle and wall momenta.

  11. Particle Energy And Acceleration Efficiencies In Highly Relativistic Shocks

    E-print Network

    A. Meli; J. J. Quenby

    2001-01-23

    In this paper we present an investigation of numerical Monte Carlo simulations of the diffusive shock acceleration in the test particle limit. Very high gamma flow astrophysical plasmas, have been used, from $\\gamma_{up}$ $\\sim50$ up to $\\gamma_{up}$ $\\sim1000$, which could be relevant to the suggested models of AGNs Jets and their Central Engines as well as the ultra-relativistic shock particle acceleration in Gamma Ray Burst (GRB) fireballs. Particularly the energy gain per shock crossing and the time constant for the above high relativistic processes is numerically calculated. We explicitly find a considerable $\\gamma^{2}$ energy boosting in the first shock cycle, and in all subsequent shock cycles the particle energy is multiplied by a large factor. Also a noted acceleration speed-up for the same acceleration process has been observed. Both of those results are connected with theoretical suggestions that a significant enhancement of the acceleration process is possible due to relativistic effects not present at lower plasma flow speeds. The acceleration speed-up and the mean energy-gain per shock cycle found could efficiently justify the theory of the origin of Ultra High Energy Cosmic Rays (UHECR) from the sites of GRBs.

  12. Energy transfer theory in particle-beam generated plasmas

    NASA Astrophysics Data System (ADS)

    Peyraud, N.

    1984-11-01

    The equilibrium electron distributions in the tail and body of a particle-beam-generated plasma are calculated theoretically from the nonlocal Boltzmann equation (accounting for elastic and inelastic collisional processes and including a continuous source term); general expressions for the electron temperature and density (for any target gas, particle beam, and energy level) are derived; and the case of an electron-beam-generated Ar plasma is considered. Numerical results for the conditions investigated experimentally by Pointu et al. (1980), Puech (1981), and Bretagne et al. (1981) are presented in graphs and found to be in good general agreement with data.

  13. Test of statistical model predictions for alpha-particle decay of 90,92,94,96Ru compound nuclei

    Microsoft Academic Search

    B. Fornal; F. Gramegna; G. Prete; G. Nebbia; R. Smith; G. D'erasmo; L. Fiore; A. Pantaleo; G. Viesti; P. Blasi; F. Lucarelli; I. Iori; A. Moroni

    1990-01-01

    The alpha decay of Ru compound nuclei populated in 32S on 58,60,62,64Ni reactions at Ebeam=135-185 MeV has been studied. Experimental data have been compared with statistical model calculations performed with two different computer codes. The quality of the agreement between calculations and experimental data was found, in one case, to depend on the compound nucleus populated. Comparing the results from

  14. AN UPDATED {sup 6}Li(p, {alpha}){sup 3}He REACTION RATE AT ASTROPHYSICAL ENERGIES WITH THE TROJAN HORSE METHOD

    SciTech Connect

    Lamia, L.; Spitaleri, C.; Sergi, M. L. [Dipartimento di Fisica e Astronomia, Universita di Catania, I-95123 Catania (Italy); Pizzone, R. G.; Tumino, A.; La Cognata, M. [INFN-Laboratori Nazionali del Sud, I-95125 Catania (Italy); Tognelli, E.; Degl'Innocenti, S.; Prada Moroni, P. G. [Dipartimento di Fisica, Universita di Pisa, I-56127 Pisa (Italy); Pappalardo, L. [Dipartimento di Fisica e Scienze della Terra, Universita di Ferrara, I-44100 Ferrara (Italy)

    2013-05-01

    The lithium problem influencing primordial and stellar nucleosynthesis is one of the most interesting unsolved issues in astrophysics. {sup 6}Li is the most fragile of lithium's stable isotopes and is largely destroyed in most stars during the pre-main-sequence (PMS) phase. For these stars, the convective envelope easily reaches, at least at its bottom, the relatively low {sup 6}Li ignition temperature. Thus, gaining an understanding of {sup 6}Li depletion also gives hints about the extent of convective regions. For this reason, charged-particle-induced reactions in lithium have been the subject of several studies. Low-energy extrapolations of these studies provide information about both the zero-energy astrophysical S(E) factor and the electron screening potential, U{sub e} . Thanks to recent direct measurements, new estimates of the {sup 6}Li(p, {alpha}){sup 3}He bare-nucleus S(E) factor and the corresponding U{sub e} value have been obtained by applying the Trojan Horse method to the {sup 2}H({sup 6}Li, {alpha} {sup 3}He)n reaction in quasi-free kinematics. The calculated reaction rate covers the temperature window 0.01 to 2T{sub 9} and its impact on the surface lithium depletion in PMS models with different masses and metallicities has been evaluated in detail by adopting an updated version of the FRANEC evolutionary code.

  15. Synthesis of single phase. alpha. -Fe, Fe sub 3 C and Fe sub 7 C sub 3 nano-particles by CO sub 2 laser pyrolysis technique

    SciTech Connect

    Eklund, P.C.; Bi, X.X.

    1992-01-01

    Iron-containing catalysts have been known to be useful in assisting the Fischer-Tropsch (FT) reaction for synthesizing hydrocarbons. However, it has been well recognized that iron catalyst are not stable during the reaction but converted into iron carbides. It is thus important to understand the role of the iron carbides in the catalytic reaction of the FT-synthesis. It has been found difficult to produce iron carbide nano-particles as a single phase, because iron carbide phases are only metastable under 1 atm pressure. Iron carbide bulk particles prepared so far are often contaminated with metallic iron, iron oxides and free carbon. In this study, we investigate the synthesis of iron carbide nano-particles using CO{sub 2} laser pyrolysis technique. We show that this technique is successful in synthesizing {alpha}-Fe, Fe{sub 3}C and Fe{sub 7}C{sub 3} nano-particles in their single phase with sizes in the range of 5--20nm. In particular, we have produced for the first time the Fe{sub 7}C{sub 3} which has been known to exist but unable to be produced as a single phase. Furthermore, it is interesting that Fe{sub 5}C{sub 2} which has carbon and iron ratio between Fe{sub 3}C and Fe{sub 7}C{sub 3}, is not seen in any run of our synthesis.

  16. Energetic particle physics issues for ITER

    SciTech Connect

    Cheng, C.Z.; Budny, R.; Fu, G.Y. [and others

    1996-12-31

    This paper summarizes our present understanding of the following energetic/alpha particle physics issues for the 21 MA, 20 TF coil ITER Interim Design configuration and operational scenarios: (a) toroidal field ripple effects on alpha particle confinement, (b) energetic particle interaction with low frequency MHD modes, (c) energetic particle excitation of toroidal Alfven eigenmodes, and (d) energetic particle transport due to MHD modes. TF ripple effects on alpha loss in ITER under a number of different operating conditions are found to be small with a maximum loss of 1%. With careful plasma control in ITER reversed-shear operation, TF ripple induced alpha loss can be reduced to below the nominal ITER design limit of 5%. Fishbone modes are expected to be unstable for {beta}{sub {alpha}} > 1%, and sawtooth stabilization is lost if the ideal kink growth rate exceeds 10% of the deeply trapped alpha precessional drift frequency evaluated at the q = 1 surface. However, it is expected that the fishbone modes will lead only to a local flattening of the alpha profile due to small banana size. MHD modes observed during slow decrease of stored energy after fast partial electron temperature collapse in JT-60U reversed-shear experiments may be resonant type instabilities; they may have implications on the energetic particle confinement in ITER reversed-shear operation. From the results of various TAE stability code calculations, ITER equilibria appear to lie close to TAE linear stability thresholds. However, the prognosis depends strongly on q profile and profiles of alpha and other high energy particles species. If TAE modes are unstable in ITER, the stochastic diffusion is the main loss mechanism, which scales with ({delta}B{sub r}/B){sup 2}, because of the relatively small alpha particle banana orbit size. For isolated TAE modes the particle loss is very small, and TAE modes saturate via the resonant wave-particle trapping process at very small amplitude.

  17. H Ly-alpha transmittance of thin foils of C, Si/C, and Al/C for keV particle detectors

    NASA Technical Reports Server (NTRS)

    Drake, V. A.; Sandel, B. R.; Jenkins, D. G.; Hsieh, K. C.

    1992-01-01

    A class of instruments designed for remote sensing of space plasmas by measuring energetic neutral atoms (ENA) uses a thin foil as both a signal generator and a light shield. An ENA imager must look directly at the ENA source region, which is also usually an intense source of H Ly-alpha (1216 A) photons. It is desirable to minimize the energy threshold for ENA detectors, at the same time maximizing the blocking of H Ly-alpha. Optimizing filter design to meet these two contrary requirements has led us to measure the transmittance of thin C, Si/C, and Al/C foils at H Ly-alpha. Our results indicate that (1) transmittance of less than 0.0007 can be achieved with 7 micro-g/sq cm Si on 1.7 micro-g/sq cm C; (2) an Si/C composite foil with a thin carbon layer is more effective in blocking UV radiation while having the lowest energy threshold of all the foils measured; and (3) transmittance of Si/C foils of known Si and C thicknesses cannot be accurately predicted, but must be measured.

  18. Strain fields around high-energy ion tracks in {alpha}-quartz

    SciTech Connect

    Follstaedt, D. M.; Norman, A. K.; Doyle, B. L.; McDaniel, F. D. [Radiation-Solid Interactions and Processing Department 1111, Sandia National Laboratories, P.O. Box 5800, MS 1056, Albuquerque, New Mexico 87185-1056 (United States); Ion Beam Modification and Analysis Laboratory, Department of Physics, University of North Texas, P.O. Box 311427, Denton, Texas 76203-1427 (United States)

    2006-09-15

    Transmission electron microscopy has been used to image the tracks of high-energy {sup 197}Au{sup +26} (374 MeV) and {sup 127}I{sup +18} (241 MeV) ions incident in a nonchanneling direction through a prethinned specimen of hexagonal {alpha}-quartz (SiO{sub 2}). These ions have high electronic stopping powers in quartz, 24 and 19 keV/nm, respectively, which are sufficient to produce a disordered latent track. When the tracks are imaged with diffraction contrast using several different reciprocal lattice vectors, they exhibit a radial strain extending outward from their disordered centerline approximately 16 nm into the crystalline surroundings. The images are consistent with a radial strain field with cylindrical symmetry around the amorphous track, like that found in models developed to account for the lateral expansion of amorphous SiO{sub 2} films produced by irradiation with high-energy ions. These findings provide an experimental basis for increased confidence in such modeling.

  19. Charged-particle mutagenesis II. Mutagenic effects of high energy charged particles in normal human fibroblasts

    NASA Astrophysics Data System (ADS)

    Chen, D. J.; Tsuboi, K.; Nguyen, T.; Yang, T. C.

    1994-10-01

    The biological effects of high LET charged particles are a subject of great concern with regard to the prediction of radiation risk in space. In this report, mutagenic effects of high LET charged particles are quantitatively measured using primary cultures of human skin fibroblasts, and the spectrum of induced mutations are analyzed. The LET of the charged particles ranged from 25 KeV/?m to 975 KeV/gmm with particle energy (on the cells) between 94 - 603 MeV/u. The X-chromosome linked hypoxanthine guanine phosphoribosyl transferase (hprt) locus was used as the target gene. Exposure to these high LET charged particles resulted in exponential survival curves; whereas, mutation induction was fitted by a linear model. The Relative Biological Effect (RBE) for cell-killing ranged from 3.73 to 1.25, while that for mutant induction ranged from 5.74 to 0.48. Maximum RBE values were obtained at the LET of 150 keV/?m. The inactivation cross-section (?i) and the action-section for mutant induction (?m) ranged from 2.2 to 92.0 ?m2 and 0.09 to 5.56 × 10-3 ?m2, respectively. The maximum values were obtained by 56Fe with an LET of 200 keV/?m. The mutagenicity (?m/?i) ranged from 2.05 to 7.99 × 10-5 with the maximum value at 150 keV/?m. Furthermore, molecular analysis of mutants induced by charged particles indicates that higher LET beams are more likely to cause larger deletions in the hprt locus.

  20. Kinetic-Energy Distribution of D(2p) Atoms from Analysis of the D Lyman-Alpha Line Profile

    NASA Technical Reports Server (NTRS)

    Ciocca, M.; Ajello, Joseph M.; Liu, Xianming; Maki, Justin

    1997-01-01

    The kinetic-energy distribution of D(2p) atoms resulting from electron-impact dissociation of D2 has been measured. A high-resolution vacuum ultraviolet spectrometer was employed for the first measurement of the D Lyman-alpha (D L(alpha)) emission line profiles at 20- and 100-eV excitation energies. Analysis of the deconvoluted line profile of D L(alpha) at 100 eV reveals the existence of a narrow line central peak of 29+/-2 mA full width at half maximum and a broad pedestal wing structure about 190 mA wide. The wings of the line can be used to determine the fast atom distribution. The wings of D L(alpha) arise from dissociative excitation of a series of doubly excited states that cross the Franck-Condon region between 23 and 40 eV. The fast atom distribution at 100-eV electron impact energy spans the energy range from 1 to 10 eV with a peak value near 6 eV. Slow D(2p) atoms characterized by a distribution function with peak energy near 100 meV produce the central peak profile, which is nearly independent of the impact energy. The deconvoluted line profiles of the central peak at 20 eV for dissociative excitation of D2 and H2 are fitted with an analytical function for use in calibration of space flight instrumentation equipped with a D/H absorption cell. The kinetic-energy and line profile results are compared to similar measurements for H2. The absolute cross sections for the line center (slow atoms) and wings (fast atoms) and total emission line profile were measured from threshold to 400 eV. Analytical model coefficients are given for the energy dependence of the measured slow atom cross section.